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["Protein FDR Confidence: Combined","Accession","Description","Coverage [%]","# Peptides","# PSMs","# Unique Peptides","# AAs","MW [kDa]","calc. pI","Score Sequest HT: Sequest HT","Biological Process","Cellular Component","Molecular Function","Gene Symbol","Ensembl Gene ID","WikiPathways","Reactome Pathways","KEGG Pathways","Abundance Ratio: (ARV) / (DMSO)","Abundance Ratio: (CF3-P) / (DMSO)","Abundance Ratio: (CI-P) / (DMSO)","Abundance Ratio: (F-P) / (DMSO)","Abundance Ratio: (Le-P) / (DMSO)","Abundance Ratio Adj. P-Value: (ARV) / (DMSO)","Abundance Ratio Adj. P-Value: (CF3-P) / (DMSO)","Abundance Ratio Adj. P-Value: (CI-P) / (DMSO)","Abundance Ratio Adj. P-Value: (F-P) / (DMSO)","Abundance Ratio Adj. P-Value: (Le-P) / (DMSO)","Abundances (Grouped): ARV","Abundances (Grouped): CF3-P","Abundances (Grouped): CI-P","Abundances (Grouped): DMSO","Abundances (Grouped): F-P","Abundances (Grouped): Le-P","Abundances (Scaled): F19: 127N, Sample, ARV","Abundances (Scaled): F19: 128N, Sample, ARV","Abundances (Scaled): F19: 129N, Sample, ARV","Abundances (Scaled): F19: 133N, Sample, CF3-P","Abundances (Scaled): F19: 134N, Sample, CF3-P","Abundances (Scaled): F19: 135N, Sample, CF3-P","Abundances (Scaled): F19: 132C, Sample, CI-P","Abundances (Scaled): F19: 133C, Sample, CI-P","Abundances (Scaled): F19: 134C, Sample, CI-P","Abundances (Scaled): F19: 126, Sample, DMSO","Abundances (Scaled): F19: 127C, Sample, DMSO","Abundances (Scaled): F19: 128C, Sample, DMSO","Abundances (Scaled): F19: 130N, Sample, F-P","Abundances (Scaled): F19: 131N, Sample, F-P","Abundances (Scaled): F19: 132N, Sample, F-P","Abundances (Scaled): F19: 129C, Sample, Le-P","Abundances (Scaled): F19: 130C, Sample, Le-P","Abundances (Scaled): F19: 131C, Sample, Le-P","Abundances (Normalized): F19: 127N, Sample, ARV","Abundances (Normalized): F19: 128N, Sample, ARV","Abundances (Normalized): F19: 129N, Sample, ARV","Abundances (Normalized): F19: 133N, Sample, CF3-P","Abundances (Normalized): F19: 134N, Sample, CF3-P","Abundances (Normalized): F19: 135N, Sample, CF3-P","Abundances (Normalized): F19: 132C, Sample, CI-P","Abundances (Normalized): F19: 133C, Sample, CI-P","Abundances (Normalized): F19: 134C, Sample, CI-P","Abundances (Normalized): F19: 126, Sample, DMSO","Abundances (Normalized): F19: 127C, Sample, DMSO","Abundances (Normalized): F19: 128C, Sample, DMSO","Abundances (Normalized): F19: 130N, Sample, F-P","Abundances (Normalized): F19: 131N, Sample, F-P","Abundances (Normalized): F19: 132N, Sample, F-P","Abundances (Normalized): F19: 129C, Sample, Le-P","Abundances (Normalized): F19: 130C, Sample, Le-P","Abundances (Normalized): F19: 131C, Sample, Le-P","Found in Sample: [S254] F19: 127N, Sample, ARV","Found in Sample: [S256] F19: 128N, Sample, ARV","Found in Sample: [S258] F19: 129N, Sample, ARV","Found in Sample: [S266] F19: 133N, Sample, CF3-P","Found in Sample: [S268] F19: 134N, Sample, CF3-P","Found in Sample: [S270] F19: 135N, Sample, CF3-P","Found in Sample: [S265] F19: 132C, Sample, CI-P","Found in Sample: [S267] F19: 133C, Sample, CI-P","Found in Sample: [S269] F19: 134C, Sample, CI-P","Found in Sample: [S253] F19: 126, Sample, DMSO","Found in Sample: [S255] F19: 127C, Sample, DMSO","Found in Sample: [S257] F19: 128C, Sample, DMSO","Found in Sample: [S260] F19: 130N, Sample, F-P","Found in Sample: [S262] F19: 131N, Sample, F-P","Found in Sample: [S264] F19: 132N, Sample, F-P","Found in Sample: [S259] F19: 129C, Sample, Le-P","Found in Sample: [S261] F19: 130C, Sample, Le-P","Found in Sample: [S263] F19: 131C, Sample, Le-P","# Protein Groups"]
["High","Q15059","bromodomain-containing protein 3 [OS=Homo sapiens]",18,11,30,8,726,79.5,9.36,69.83,"cell organization and biogenesis;other biological processes","nucleus","other molecular function","BRD3","ENSG00000169925","","","",0.203,0.261,0.235,0.211,0.204,1.99759703223279e-07,3.00110620798932e-06,1.35500590747739E-6,1.67900067922962e-07,7.04237976413923e-08,57.7,74.1,66.7,283.9,59.9,57.8,53.5,58.5,61.6,67.9,75.1,75.9,67.4,67.6,69.4,296.4,266.9,287.8,62.2,59.5,60.7,47.2,63.8,58.6,644.8,705.4,743,818.6,905.4,915.3,813.3,815.4,837.3,3574.8,3219.5,3471.1,750.5,717.3,731.8,568.9,769.8,706.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8IXZ3-1","Isoform 1 of Transcription factor Sp8 [OS=Homo sapiens]",3,1,1,1,448,45.2,8.91,2.83,"","","","SP8","","","","",0.319,0.709,0.469,0.626,0.541,0.0176384632402826,1,0.111373864769617,0.459643889723521,0.158795540707963,52.3,116.1,76.7,163.7,102.5,88.6,48.8,92.5,48.8,126.9,108.4,95.8,95.8,63.5,71.6,151.4,194.3,152.8,82.3,95.7,117.5,82.7,99.5,71.8,6.3,11.9,6.3,16.3,13.9,12.3,12.3,8.2,9.2,19.4,25,19.6,10.6,12.3,15.1,10.6,12.8,9.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O60885-1","Bromodomain-containing protein 4 [OS=Homo sapiens]",12,13,29,10,1362,152.1,9.19,40.31,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD4","ENSG00000141867; ENSPTRG00000010619","VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome","Potential therapeutics for SARS","",0.339,0.402,0.343,0.327,0.285,1.67696661715741E-7,2.64223882773251e-06,3.11151465703929E-7,3.87991212075223e-08,1.07670719562414e-08,75.5,89.5,76.2,222.5,72.8,63.5,75.8,72.2,78.4,80.4,93.5,90,78.2,72.5,76.6,235.2,212.4,223.6,75.6,68,73.2,67.5,63.8,62.9,766.9,730.2,793.1,812.9,946,909.9,790.9,733.5,774.5,2378.7,2148.6,2261.3,764.8,688.1,740.4,682.5,645,636.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NRN5-1","Olfactomedin-like protein 3 [OS=Homo sapiens]",9,2,4,2,406,46,6.57,13,"","non-structural extracellular","","OLFML3","ENSG00000116774; ENSPTRG00000001131","","","",0.362,0.44,0.374,0.35,0.351,0.00351653779248035,0.0346872818133967,0.0140814317390534,0.00451712414095957,0.00939584072625411,75.5,91.7,78.1,208.5,72.9,73.2,77,75.5,60.2,97.2,91.6,74.6,78,87.2,77.5,208.4,194.9,209.9,79.1,63.8,72.9,57.8,121.2,73.2,23.9,23.5,18.7,30.2,28.5,23.2,24.2,27.1,24.1,64.8,60.6,65.3,24.6,19.8,22.7,18,37.7,22.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9HD67","Unconventional myosin-X [OS=Homo sapiens]",3,5,5,4,2058,237.2,6.21,9.78,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","MYO10","ENSG00000145555","","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Netrin-1 signaling","Fc gamma R-mediated phagocytosis; Pathogenic Escherichia coli infection",0.37,0.414,0.322,0.395,0.387,0.00951985353742685,0.0450538274240464,0.00622254964350534,0.0160200150001192,0.00303896242972139,76.9,86,66.9,207.7,82.1,80.3,74.3,77.9,81.3,87.2,93.9,82.9,67.9,77.4,62.1,224.7,200.8,210.6,88.6,83.2,78.8,88.3,38.7,81.4,60.9,63.9,66.6,71.5,77,68,55.6,63.4,50.9,184.2,164.6,172.6,72.6,68.2,64.6,72.4,31.7,66.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UJQ4","Sal-like protein 4 [OS=Homo sapiens]",19,14,33,13,1053,112.2,7.47,77.44,"cell cycle OR cell proliferation;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SALL4","ENSG00000101115","Vitamin D receptor pathway; Wnt/beta-catenin signaling pathway in leukemia","Regulation of PTEN gene transcription; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","",0.375,0.773,0.762,0.697,0.649,9.10895618192834e-09,0.0010931004780837,3.23125940684864E-4,3.22233040461118e-05,4.98955771757882e-06,52.8,109,107.4,141,98.3,91.5,54.2,51.9,52.9,109.2,108.9,111.1,107.6,109.3,103.4,144,132.9,141.3,103.7,96.9,98.5,94.6,91.7,87.7,935.4,896.8,914.1,1885.9,1880.4,1917.3,1857.7,1887.2,1784.7,2486.9,2293.8,2439.5,1790.5,1673.2,1701.3,1633.1,1583,1514.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96QD8","sodium-coupled neutral amino acid transporter 2 [OS=Homo sapiens]",9,2,6,2,506,56,8,20.87,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC38A2","ENSG00000134294","Endochondral ossification; Endochondral ossification with skeletal dysplasias; Neuroinflammation and glutamatergic signaling","Glutamate Neurotransmitter Release Cycle; Amino acid transport across the plasma membrane","Glutamatergic synapse; GABAergic synapse; Protein digestion and absorption",0.405,0.489,0.433,0.5,0.401,1.20868314844811E-3,0.0234278516167938,3.11217200993576E-3,0.00739113119752314,0.00241274008572908,75.3,90.9,80.5,185.8,92.9,74.6,72.9,63.2,80.1,102.5,87.1,88.1,68,78,83.5,215.2,179.2,180,90,75.8,98.8,62.7,102.8,72.3,33.1,28.7,36.3,46.5,39.5,40,30.8,35.4,37.9,97.6,81.3,81.7,40.8,34.4,44.8,28.4,46.6,32.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P19438-1","Tumor necrosis factor receptor superfamily member 1A [OS=Homo sapiens]",9,2,2,2,455,50.5,6.64,0,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","TNFRSF1A","ENSG00000067182","Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanoparticle triggered regulated necrosis; Apoptosis; Cardiac hypertrophic response; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Apoptosis modulation by HSP70; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Inflammatory response pathway; IL-18 signaling pathway; Regucalcin in proximal tubule epithelial kidney cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease","TNFs bind their physiological receptors; Interleukin-10 signaling; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; TNFR1-mediated ceramide production; TNFR1-induced proapoptotic signaling","MAPK signaling pathway; Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; NF-kappa B signaling pathway; Sphingolipid signaling pathway; mTOR signaling pathway; Apoptosis; Apoptosis; Necroptosis; Osteoclast differentiation; TNF signaling pathway; Adipocytokine signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Alzheimer disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis C; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",0.411,0.641,0.569,0.565,0.43,0.00506003178904182,0.139403294291851,0.0857836996200897,0.0499177805681567,0.00440796659326083,68.3,106.3,94.4,165.9,93.7,71.4,94.4,68,56,114.7,73.5,105.9,106.2,94,84.6,165.2,164,190.1,93.3,84.9,96.9,71.8,71.1,65.5,15.4,11.1,9.1,18.7,12,17.3,17.3,15.3,13.8,27,26.8,31,15.2,13.9,15.8,11.7,11.6,10.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P25440-1","Bromodomain-containing protein 2 [OS=Homo sapiens]",9,4,7,4,801,88,9.09,15.21,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD2","ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307; ENSGGOG00000043461","","RUNX3 regulates p14-ARF","",0.447,0.438,0.375,0.374,0.421,1.06053077007884E-5,1.74793842940786e-05,2.61761335720404e-06,2.49322091900555e-06,4.79538295564233e-06,87.8,86.1,73.6,196.3,73.5,82.7,87.5,94.9,84,78.2,85.8,91.2,65.9,76.1,73.3,195.6,187.5,205.8,72.4,73.2,82.4,85.3,82.4,78.4,152.8,165.7,146.6,136.6,149.7,159.2,115.1,132.8,128.1,341.6,327.4,359.3,126.5,127.8,143.9,149,143.8,136.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","P55318","Hepatocyte nuclear factor 3-gamma [OS=Homo sapiens]",3,1,2,1,350,37.1,7.47,0,"cell organization and biogenesis;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXA3","ENSG00000170608","","Regulation of gene expression in beta cells","Maturity onset diabetes of the young",0.458,0.602,0.577,0.506,0.52,7.39541582499953e-05,0.00713568847047708,1.53882534822269E-3,0.000198031103019557,0.000214173189040494,74.9,98.7,94.5,163.8,82.9,85.1,72.5,74.3,86,97.9,97.1,111.3,90.4,93.8,100.5,162.5,168.2,139.9,80.7,86.9,82.3,90.3,84.4,81,75.9,77.8,89.9,102.4,101.5,116.4,94.6,98.1,105.1,170,176,146.4,84.5,90.9,86.1,94.5,88.3,84.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q8TD31-1","Coiled-coil alpha-helical rod protein 1 [OS=Homo sapiens]",1,1,1,1,782,88.6,5.95,1.83,"transport;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CCHCR1","ENSG00000204536; ENSG00000206355; ENSG00000206457; ENSG00000234114","","","",0.464,0.606,0.452,0.449,0.539,1.52964757175165E-3,0.0726152740822625,0.00434350952042099,0.00214412966829088,0.00847399391002042,79.3,103.6,77.3,171,76.7,92.1,83.4,77.6,68.2,101.4,114.7,93.2,75.7,92.9,75.6,178.5,165.7,167.3,88,75.1,71,90.2,72.4,109.2,35.7,33.2,29.2,43.4,49.1,39.9,32.4,39.8,32.4,76.4,70.9,71.6,37.7,32.1,30.4,38.6,31,46.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O43597","Protein sprouty homolog 2 [OS=Homo sapiens]",6,2,3,2,315,34.7,8.35,9.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","SPRY2","ENSG00000136158","Glioblastoma signaling pathways; Ectoderm differentiation; EGF/EGFR signaling pathway","EGFR downregulation; Spry regulation of FGF signaling","MicroRNAs in cancer",0.483,0.433,0.454,0.496,0.566,1.40912938327408E-4,1.46754998184891E-4,0.000234148561828782,2.68822084382346E-4,0.00132236928108626,84.5,75.7,79.4,174.8,86.8,98.9,87.7,78.9,84.3,81.5,73.5,75.6,78.3,94,79.2,174.5,160.5,174.4,83.5,86.6,89.7,86.1,113.1,98.6,125.2,112.7,120.4,116.4,104.9,107.9,111.9,134.2,113.1,249.2,229.2,249,119.2,123.6,128.1,123,161.5,140.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y6Y0","influenza virus NS1A-binding protein [OS=Homo sapiens]",10,5,7,5,642,71.7,5.53,11.53,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","IVNS1ABP","ENSG00000116679","","","",0.485,0.53,0.495,0.469,0.397,0.000250006466385507,2.03878314130518E-3,0.000474684906245509,0.000164824713722004,5.28080978582223e-05,86.3,94.2,88,177.7,83.4,70.5,80.6,91.4,86.4,94.4,97.3,94,89.4,82.2,88.1,159.9,191.3,178,74.4,85.1,83.5,70.6,64.9,88.5,263.2,298.3,282.2,308.1,317.7,306.8,291.9,268.4,287.7,522.2,624.7,581.2,243,277.7,272.8,230.6,211.9,289.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q96MM7","Heparan-sulfate 6-O-sulfotransferase 2 [OS=Homo sapiens]",1,1,2,1,605,69.1,9.73,3.71,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","HS6ST2","ENSG00000171004","Metapathway biotransformation Phase I and II","HS-GAG biosynthesis","Glycosaminoglycan biosynthesis",0.494,0.493,0.433,0.472,0.489,0.0292101553590777,0.0463438766697383,0.00957187626246109,0.00881671786460985,0.0188024870376156,87.7,87.4,76.8,177.5,83.8,86.8,109.7,76.7,89.6,89.4,88.6,89.9,78.5,64.2,94.9,193.1,140.7,181.5,85.6,89.8,66.5,89.6,82.8,88.8,86.4,60.4,70.6,70.4,69.8,70.8,61.8,50.6,74.7,152.1,110.8,142.9,67.4,70.8,52.4,70.6,65.2,69.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","P41221","protein Wnt-5a [OS=Homo sapiens]",3,2,2,2,380,42.3,8.46,4.24,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","WNT5A","ENSG00000114251","MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Pluripotent stem cell differentiation pathway; Extracellular vesicle-mediated signaling in recipient cells; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)","Class B/2 (Secretin family receptors); Asymmetric localization of PCP proteins; WNT ligand biogenesis and trafficking; Cargo recognition for clathrin-mediated endocytosis; Ca2+ pathway; WNT5:FZD7-mediated leishmania damping; WNT5A-dependent internalization of FZD4; Negative regulation of TCF-dependent signaling by WNT ligand antagonists; WNT5A-dependent internalization of FZD2, FZD5 and ROR2","mTOR signaling pathway; Wnt signaling pathway; Axon guidance; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",0.496,0.675,0.61,0.505,0.484,7.60397684750704e-05,0.00810574964138854,0.0012730444079641,1.61559606546346E-4,5.21787429135382e-05,78.9,107.5,97.1,159.1,80.4,77.1,80.6,78.6,75.2,97,109.8,107.1,103,85.7,96.8,179.6,149.1,158.6,80.1,88.3,79.9,76.8,70.4,83.4,195.9,191.1,182.8,235.8,266.9,260.5,250.5,208.3,235.3,436.5,362.4,385.7,194.8,214.7,194.3,186.8,171.2,202.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","Q2TAK8-1","PWWP domain-containing protein MUM1 [OS=Homo sapiens]",2,1,1,1,710,78.6,8.54,0,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","other molecular function","PWWP3A","ENSG00000160953","IL-18 signaling pathway","","",0.496,0.615,0.576,0.6,0.595,0.000944747680096983,0.0208826458193206,0.0088465022694539,0.0123878271904182,0.0181180050609935,76.7,95,89,154.6,92.7,92,76.7,65.8,80.4,81.5,95.1,96.9,89.1,76.9,97.5,154.7,138.3,183.7,92.8,86.4,97.4,92,86.7,107.9,27.7,23.8,29,29.4,34.3,35,32.2,27.8,35.2,55.8,49.9,66.3,33.5,31.2,35.2,33.2,31.3,38.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8IVP5","FUN14 domain-containing protein 1 [OS=Homo sapiens]",11,1,4,1,155,17.2,8.62,8.05,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion","","FUNDC1","ENSG00000069509","","Receptor Mediated Mitophagy","Mitophagy",0.498,0.714,0.511,0.526,0.289,0.812038674694712,1,1,1,0.0781609180496493,84.5,121.1,86.6,169.6,89.2,49.1,82.5,116.9,69.6,106.9,122.6,118.3,83.6,105.2,84.6,106,168.3,165.6,73,128.8,87.1,47.9,45.9,87.1,21.6,30.6,18.2,27.9,32.1,30.9,21.9,27.5,22.1,27.7,44,43.3,19.1,33.7,22.8,12.5,12,22.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P13611","Versican core protein [OS=Homo sapiens]",1,2,2,2,3396,372.6,4.51,0,"cell adhesion;developmental processes;other biological processes","extracellular matrix;ER/Golgi;other cytoplasmic organelle;other cell component","extracellular structural activity;other molecular function","VCAN","ENSG00000038427","Spinal cord injury","ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; A tetrasaccharide linker sequence is required for GAG synthesis; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective B3GALT6 causes EDSP2 and SEMDJL1; Chondroitin sulfate biosynthesis; Dermatan sulfate biosynthesis; CS/DS degradation; Defective CHST3 causes SEDCJD; Defective CHST14 causes EDS, musculocontractural type; Defective CHSY1 causes TPBS","Cell adhesion molecules",0.499,0.557,0.472,0.503,0.467,0.0357317030848156,0.162099800783827,0.023301918451727,0.0294611598141463,0.0363800910565286,85.6,95.6,81,171.5,86.2,80.1,113.8,83.2,66.7,85.3,92.9,107.7,77.5,81.3,78.7,166.7,138.9,195.9,78.5,83.8,89,77.8,77.6,104.4,43.6,31.9,25.6,32.6,35.6,41.2,29.7,31.1,30.1,63.8,53.2,75,30.1,32.1,34.1,29.8,29.7,40,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q96L96","Alpha-protein kinase 3 [OS=Homo sapiens]",1,1,1,1,1907,201.1,7.58,2.57,"protein metabolism;other metabolic processes;developmental processes","nucleus","kinase activity;other molecular function","ALPK3","ENSG00000136383","","","",0.502,0.66,0.698,0.637,0.654,0.000204763368119271,0.0181131424601196,0.0291339592025572,0.00474552329084751,0.0495363795330659,72.6,95.4,100.9,144.6,92,94.6,70,71.8,73.6,94.4,88.6,97.8,100.3,99.8,95.7,143.1,137.8,145.2,86.3,91.5,91.1,92,127.3,93.6,54.5,56,57.4,73.5,69,76.2,78.2,77.8,74.5,111.5,107.3,113.1,67.2,71.3,71,71.7,99.2,72.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O43286","Beta-1,4-galactosyltransferase 5 [OS=Homo sapiens]",8,2,2,2,388,45.1,8.15,3.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","B4GALT5","ENSG00000158470","","N-Glycan antennae elongation; Keratan sulfate biosynthesis; O-linked glycosylation of mucins","Mucin type O-glycan biosynthesis; Metabolic pathways",0.502,0.433,0.583,0.439,0.535,0.0025115283676156,0.00382633421914552,0.022417294068047,0.000965123721125549,0.00638515217383769,86.3,74.4,100.2,171.8,75.4,91.9,72.2,93.2,90,76.1,90,77.6,85.5,104.5,107.1,144.3,179.6,179.2,68.8,79.4,78.6,95.8,81.3,96.7,32.6,42,40.6,34.3,40.6,35,38.6,47.2,48.3,65.1,81.1,80.9,31,35.8,35.5,43.2,36.7,43.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","P56181-2","Isoform 2 of NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [OS=Homo sapiens]",2,1,1,1,473,51,9.17,0,"","","","NDUFV3","","","","",0.509,0.707,0.597,0.763,0.559,0.242268418918265,1,1,1,0.51248560375081,73.9,102.6,86.6,145.1,110.7,81.1,79.2,71.2,55.8,96.8,98.9,103.9,83.4,113.3,80.3,202.2,139.8,102.1,148.7,106.7,72.3,78.1,60.8,106.5,13,11.7,9.2,15.9,16.3,17.1,13.7,18.7,13.2,33.3,23,16.8,24.5,17.6,11.9,12.9,10,17.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9BYV2","tripartite motif-containing protein 54 [OS=Homo sapiens]",8,2,2,2,358,40.3,5.22,5.86,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","TRIM54","ENSG00000138100","","","",0.515,0.46,0.513,0.6,0.602,0.00115107998820777,5.44318142478027E-4,1.63283488084121E-3,0.00760581356236543,0.00847399391002042,83.7,74.9,83.4,162.6,97.6,97.8,80.9,93.5,82.9,74.1,80.4,68.7,95.3,77,82.6,178.3,136.7,161,93.3,96.6,103.2,92.9,105.7,96.9,39.6,45.8,40.6,36.3,39.4,33.6,46.7,37.7,40.5,87.3,67,78.9,45.7,47.3,50.6,45.5,51.8,47.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y4A8","nuclear factor erythroid 2-related factor 3 [OS=Homo sapiens]",2,1,1,1,694,76.1,5.44,3.21,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFE2L3","ENSG00000050344","","","",0.526,0.549,0.57,0.649,0.643,0.0169761787060409,0.0545508274928373,0.0940639891615015,0.093401359454643,0.22502690230277,80.1,83.7,86.8,152.4,98.9,98,69.8,88.2,78.1,81.6,91.6,75.7,102.5,84.7,83.6,148.6,148.2,159.7,96.4,114.5,70.8,95.6,90.1,120.1,19.3,24.4,21.6,22.6,25.4,21,28.4,23.4,23.2,41.2,41,44.2,26.7,31.7,19.6,26.5,24.9,33.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96B01","RAD51-associated protein 1 [OS=Homo sapiens]",13,4,8,4,352,38.4,9.11,14.53,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity","RAD51AP1","ENSG00000111247","","Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function","",0.528,0.618,0.557,0.558,0.592,0.000126965614030508,3.03042410322279E-3,3.72182929687611E-4,0.000458282039563949,0.000342263272557028,82.2,96.3,86.7,155.7,86.9,92.2,82.8,76.4,84.9,92.1,101.2,97,87.3,79.8,89.4,168.4,156.9,150.6,85.6,93.7,87.6,97.7,75.6,92.9,390.2,360,400.1,434.1,476.8,457.3,411.6,376.2,421.1,793.7,739.3,709.5,403.2,441.6,412.7,460.4,356.4,437.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q9NY26","Zinc transporter ZIP1 [OS=Homo sapiens]",4,1,1,1,324,34.2,5.92,3.04,"transport;developmental processes","plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding;transporter activity","SLC39A1","ENSG00000143570","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis","Zinc influx into cells by the SLC39 gene family","Alzheimer disease; Parkinson disease",0.53,1.071,0.871,0.808,0.959,1,1,1,1,1,60.7,122.7,99.7,114.5,92.6,109.8,44.1,56.2,11.1,148,81.3,89.1,72.4,219.9,55.6,107,83.1,79.7,49.6,67.2,135,79.7,354.2,66.9,11.8,15,3,39.5,21.7,23.8,19.3,58.8,14.8,28.6,22.2,21.3,13.2,18,36.1,21.3,94.6,17.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q6PCD5","E3 ubiquitin-protein ligase RFWD3 [OS=Homo sapiens]",2,1,1,1,774,85,6.46,2.59,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","RFWD3","ENSG00000168411","","","",0.531,0.891,0.77,0.803,0.8,1,1,1,1,1,66.4,111.5,96.3,125.1,100.5,100.1,438.3,42.3,53.5,113.9,68,89.9,77.7,52.3,85.8,113.9,55,100.9,81,47.9,144.8,68.7,85.3,80.7,75.1,7.3,9.2,19.5,11.7,15.4,13.3,9,14.7,19.5,9.4,17.3,13.9,8.2,24.8,11.8,14.6,13.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9P0K8","Forkhead box protein J2 [OS=Homo sapiens]",2,1,1,1,574,62.4,6.7,3.24,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXJ2","ENSG00000065970","","","",0.533,0.681,0.611,0.615,0.653,1.2550293664252E-3,0.095527836106681,0.0291339592025572,0.0132186894100238,0.022209464088387,78.1,99.9,89.5,146.6,90.2,95.7,64.5,79.5,80.8,93.6,101.7,102.4,91.1,89.7,99.1,157.6,149.3,138.3,95.3,91.9,82.6,108.6,97.5,76.5,40.8,50.3,51.1,59.1,64.3,64.7,57.6,56.7,62.6,99.6,94.4,87.4,60.2,58.1,52.2,68.7,61.6,48.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9ULJ3","Zinc finger and BTB domain-containing protein 21 [OS=Homo sapiens]",6,5,6,5,1066,118.8,8.29,13.65,"other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","ZBTB21","ENSG00000173276","","","",0.537,1.112,1.09,1.103,1.108,5.69884755212525E-4,1,1,1,1,54.1,112.2,109.9,100.9,111.2,111.7,48.7,67.5,53.4,108.6,110.6,118,108.8,108.4,104.6,96.3,102.2,99.4,109.6,108.9,117.4,119.1,108.4,110.1,56.6,78.4,62,126.1,128.5,137.1,126.4,125.9,121.5,111.8,118.8,115.5,127.4,126.6,136.3,138.3,125.9,128,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UNN8","Endothelial protein C receptor [OS=Homo sapiens]",5,1,3,1,238,26.7,7.18,4.91,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","PROCR","ENSG00000101000","","Cell surface interactions at the vascular wall; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",0.542,0.754,0.652,0.64,0.566,0.00305104229565682,0.208982083082234,0.020154757333766,0.0569172523216148,0.00491274659584527,78.3,108.9,94.2,144.5,92.5,81.7,70.2,85.2,79.2,115.6,87.4,110.2,73.7,98.3,95.3,144,158.1,146.2,107.6,92.9,93.6,74.4,85.6,82.7,18.4,22.3,20.7,30.3,22.9,28.8,19.3,25.7,24.9,37.7,41.4,38.3,28.2,24.3,24.5,19.5,22.4,21.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96JG8-1","Melanoma-associated antigen D4 [OS=Homo sapiens]",11,5,10,4,741,81.3,6.79,27.57,"","","","MAGED4; MAGED4B","ENSG00000154545; ENSG00000187243","","","",0.542,0.713,0.606,0.52,0.554,0.000417620252267271,0.0436864459107304,0.00431932568388496,0.00073754790227358,0.000916845031665766,82.7,108.7,92.4,152.5,79.2,84.5,79,80.5,85.7,105.9,106.5,102.6,101.9,88.2,90,153.7,146.1,148.5,76.7,77.2,99.7,82.1,93.5,82.3,96,97.9,104.1,128.7,129.5,124.7,123.8,107.2,109.4,186.8,177.5,180.5,93.2,93.8,121.1,99.8,113.6,100.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q49A88-1","Coiled-coil domain-containing protein 14 [OS=Homo sapiens]",4,4,4,3,953,106.2,8.4,6.65,"other biological processes","cytoskeleton;other cell component","","CCDC14","ENSG00000175455","","","",0.543,0.628,0.614,0.53,0.537,4.39470228566007e-06,3.58890618390451e-05,3.36074785206838e-05,2.49322091900555e-06,3.82177428718973e-06,84.6,97.9,95.6,155.7,82.5,83.7,80.9,85.5,85.1,102.5,85.6,98.4,94.9,97.3,96.2,162.7,156.6,155.8,79,83.1,83,85.9,84.2,83.2,109,115.2,114.6,138.1,115.3,132.6,127.9,131,129.6,219.2,211,209.8,106.3,111.9,111.8,115.7,113.4,112,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96HF1","Secreted frizzled-related protein 2 [OS=Homo sapiens]",10,3,4,3,295,33.5,7.42,6.54,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SFRP2","ENSG00000145423","lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma","Negative regulation of TCF-dependent signaling by WNT ligand antagonists","Wnt signaling pathway",0.548,0.528,0.553,0.63,0.543,6.14287294821101e-05,6.75482194212318e-05,0.000126990196227989,0.000441011662949901,5.37859468331014e-05,86.5,83.4,87.3,157.8,99.4,85.7,82.6,85.9,88.3,84.8,75.6,82.8,84.6,86.6,92.3,149.8,179.8,156.7,98.7,106.3,88.6,84.6,85.1,87.2,98.2,102.1,105,100.9,89.8,98.4,100.6,103,109.7,178.1,213.8,186.3,117.3,126.3,105.3,100.6,101.1,103.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","Q96HM7","PC-esterase domain-containing protein 1B [OS=Homo sapiens]",2,1,1,1,432,49.7,9.52,0,"","","","PCED1B","ENSG00000179715","","","",0.55,0.565,0.549,0.557,0.542,0.000308632264627031,0.00203117431209768,0.000457623433032755,4.78376671898405E-4,0.000310918467524523,87.7,90,87.5,159.4,88.8,86.5,89.5,77.1,94.5,97.9,89.8,91.9,92.4,89.4,75.7,162.8,162.7,152.1,90.7,93.5,80.6,88.3,81.9,89.3,41.1,35.4,43.4,45,41.2,42.2,42.4,41,34.7,74.8,74.7,69.8,41.6,43,37,40.5,37.6,41,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q01664","Transcription factor AP-4 [OS=Homo sapiens]",7,2,2,2,338,38.7,5.87,5.46,"cell organization and biogenesis;stress response;signal transduction;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","TFAP4","ENSG00000090447","","","Proteoglycans in cancer",0.554,0.633,0.511,0.506,0.461,1.30561595313907E-3,0.0180718671441481,0.000867807677033857,0.000891628800702057,0.000209355701538346,90.7,103.6,83.7,163.7,82.9,75.4,90.4,99,75.4,94.9,107.5,103.1,85.1,83.4,74.5,200.6,163,152.8,91.4,82.5,76.2,68.5,76.5,75.1,70.4,77.1,58.8,74,83.7,80.4,66.3,65,58,156.3,127,119.1,71.2,64.3,59.4,53.4,59.6,58.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","Q9H211","DNA replication factor Cdt1 [OS=Homo sapiens]",1,1,1,1,546,60.4,9.77,1.75,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CDT1","ENSG00000167513","Retinoblastoma gene in cancer; DNA replication","Orc1 removal from chromatin; Activation of the pre-replicative complex; CDT1 association with the CDC6:ORC:origin complex; G1/S-Specific Transcription","",0.567,0.718,0.624,0.348,0.537,0.0718992430868389,1,0.611162945548859,0.013089091684279,0.185769466161031,89.7,113.6,98.6,158.2,55,84.9,50.3,99.6,89.3,114.5,95.1,113,98.2,98,105.1,202.2,130.9,157.4,72.5,54.5,54.7,84.5,103.3,77,10.7,21.2,19.1,24.4,20.3,24.1,20.9,20.9,22.4,43.1,27.9,33.6,15.5,11.6,11.7,18,22,16.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P13051","uracil-DNA glycosylase [OS=Homo sapiens]",17,3,8,3,313,34.6,9.32,9.69,"DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion;nucleus","translation activity;nucleic acid binding activity;other molecular function","UNG","ENSG00000076248","Base excision repair; DNA repair pathways, full network","","Base excision repair; Primary immunodeficiency",0.571,0.579,0.552,0.591,0.659,0.000562612933583849,0.00247897870258712,0.00114143079232708,1.8307358327501E-3,0.00232440279831818,86.7,87.8,83.9,151.8,89.7,100,82.3,87.1,86.3,99.7,87.4,80.9,83.4,94.2,82.8,155.6,151,150.8,86.4,89.3,100.3,82.3,99.4,100.7,262.7,278.1,275.5,318.3,279,258.4,266.3,300.9,264.4,496.8,482.1,481.4,275.7,285,320.2,262.7,317.5,321.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q14493-1","Histone RNA hairpin-binding protein [OS=Homo sapiens]",10,2,2,2,270,31.3,7.47,5.96,"RNA metabolism OR transcription;other metabolic processes;transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLBP","ENSG00000163950; ENSGGOG00000003167","","RNA Polymerase II Transcription Termination; Transport of the SLBP Dependant Mature mRNA; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","",0.574,0.656,0.702,0.764,0.897,0.00584851183890952,0.047063471523479,0.132736805471848,0.448968643301546,1,75,85.7,91.7,130.6,99.8,117.2,73.5,74,78.6,80,84.5,85.9,90.1,90.4,95.1,162.2,128.8,106.6,114,98.4,94.2,120.8,115.6,107.1,163.2,164.2,174.5,177.6,187.5,190.6,200.1,200.7,211,359.9,285.9,236.7,253,218.5,209.2,268.1,256.5,237.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q63HK3","Zinc finger protein with KRAB and SCAN domains 2 [OS=Homo sapiens]",2,2,2,1,967,110.9,8.35,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZKSCAN2","ENSG00000155592","","","",0.575,0.619,0.627,0.501,0.705,0.0383202113348018,0.0834302758370849,0.0614229251663563,0.0108318903511538,0.194401698503141,85.6,92.2,93.4,149,74.7,105.1,82.5,83.5,103.9,88.6,93.4,89.9,99.5,91,82.5,148,140.1,145.3,69.8,72.8,101.7,113.3,102.4,91.6,26.9,27.2,33.8,28.9,30.4,29.3,32.4,29.6,26.9,48.2,45.6,47.3,22.7,23.7,33.1,36.9,33.3,29.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P49447","Cytochrome b561 [OS=Homo sapiens]",4,1,1,1,251,27.5,8.56,2.32,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","CYB561","ENSG00000008283","","","",0.58,0.81,0.673,0.674,0.62,0.144621280905567,1,0.52170342502139,0.360377151332303,0.222042133608826,79.8,111.6,92.7,137.7,92.9,85.4,80.1,71.7,99.8,114.7,104.8,111.9,87.8,97.1,93,138.1,105,158.7,77.3,103.1,93.2,85.7,102.9,75.1,20.1,18,25,28.7,26.3,28.1,22,24.3,23.3,34.6,26.3,39.8,19.4,25.8,23.3,21.5,25.8,18.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q93045","Stathmin-2 [OS=Homo sapiens]",15,3,6,1,179,20.8,8.32,15.01,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","STMN2","ENSG00000104435","","RND1 GTPase cycle","",0.583,0.634,0.816,0.971,0.858,1,1,1,1,1,71.9,78.3,100.7,123.4,119.9,105.8,67.9,74,70.3,144.7,76.5,68.2,169.9,69.6,98.4,131.7,120.6,67.3,100.3,120,117.1,61.2,103.4,139,41.4,45.2,42.9,88.4,46.7,41.6,103.7,42.5,60.1,80.4,73.6,41.1,61.3,73.3,71.5,37.4,63.1,84.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q99969","Retinoic acid receptor responder protein 2 [OS=Homo sapiens]",12,2,2,2,163,18.6,9.09,6.15,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding","RARRES2","ENSG00000106538","","Platelet degranulation","",0.584,0.521,0.528,0.608,0.485,0.0632087415332383,0.0405294678181858,0.0221814954073339,0.0624384927511728,0.0113559089713486,94,83.8,85.1,161,98,78.1,86.4,94.4,107.3,99.6,78.7,84.2,78.5,92.6,85.5,161.8,172.7,122.5,98.4,103.7,84.9,78.5,92.2,78.1,88.8,97.1,110.4,102.4,80.9,86.6,80.7,95.2,87.9,166.3,177.5,125.9,101.2,106.6,87.3,80.7,94.8,80.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O76039-1","Cyclin-dependent kinase-like 5 [OS=Homo sapiens]",3,2,2,1,1030,115.5,9.54,2.72,"","","","CDKL5","","","","",0.585,0.753,0.712,0.595,0.598,0.019309564467571,0.869884542561276,0.134796729910983,0.00625611594717081,0.0100674508544516,82.8,106.5,100.7,141.4,84.1,84.5,76.1,105.5,81.6,101.4,128.9,105,94.4,99.2,99.6,129.2,139.4,154.4,83.5,71.3,82.9,77.9,86.3,83.3,13.1,18.1,14,17.4,22.1,18,16.2,17,17.1,22.2,23.9,26.5,14.3,12.2,14.2,13.4,14.8,14.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","Q9Y2Z2","Protein MTO1 homolog, mitochondrial [OS=Homo sapiens]",1,1,1,1,717,79.9,8.31,0,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","MTO1","ENSG00000135297","","tRNA modification in the mitochondrion","",0.593,0.97,0.819,0.923,0.511,1,1,1,1,0.658487168038453,73.8,120.8,102.1,124.6,115,63.7,97.1,76.1,74,75.1,124.6,130.2,109.8,105.3,76.9,130.5,108.9,128.5,85.1,118.6,124.2,54.9,65.7,114.5,13.7,10.7,10.4,10.6,17.6,18.4,15.5,14.8,10.8,18.4,15.4,18.1,12,16.7,17.5,7.7,9.3,16.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q92823","Neuronal cell adhesion molecule [OS=Homo sapiens]",1,1,1,1,1304,143.8,5.66,2.81,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","cytoskeletal activity","NRCAM","ENSG00000091129","","Interaction between L1 and Ankyrins; Neurofascin interactions; NrCAM interactions","Cell adhesion molecules",0.593,0.831,0.769,0.728,0.574,1,1,1,1,0.87359615909338,79.1,110.9,102.7,133.5,97.2,76.6,65.4,81.9,103.2,118.7,107.2,114.8,106.3,77.5,116.8,143.5,74.5,138.1,96.2,116.6,100.6,73.8,85.8,79.3,12.3,15.5,19.5,22.4,20.2,21.7,20.1,14.6,22,27.1,14.1,26.1,18.1,22,19,13.9,16.2,15,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P05362","Intercellular adhesion molecule 1 [OS=Homo sapiens]",20,7,10,7,532,57.8,7.99,19.14,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","ICAM1","ENSG00000090339","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; Interleukin-11 signaling pathway; Spinal cord injury; Complement system; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; VEGFA-VEGFR2 signaling pathway; miRNAs involvement in the immune response in sepsis; Cells and molecules involved in local acute inflammatory response ; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; CAMKK2 pathway; p53 transcriptional gene network; Orexin receptor pathway; Type II interferon signaling (IFNG)","Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; Interleukin-10 signaling","NF-kappa B signaling pathway; Cell adhesion molecules; Natural killer cell mediated cytotoxicity; TNF signaling pathway; Leukocyte transendothelial migration; AGE-RAGE signaling pathway in diabetic complications; African trypanosomiasis; Malaria; Staphylococcus aureus infection; Influenza A; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Rheumatoid arthritis; Viral myocarditis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",0.593,0.648,0.715,0.639,0.664,0.000253360338839798,2.99550036688042E-3,0.00670596350710841,0.000856618840450932,0.00306899098445009,83.5,91.3,100.7,140.9,90.1,93.5,90,81.2,82.8,90.5,98.5,88.4,92.1,104,99.9,141.3,132,139.7,89.4,85.2,94.7,91.3,106.2,92.8,265.3,239.4,244.3,266.8,290.5,260.6,271.4,306.6,294.4,416.6,389.1,412,263.5,251.3,279.2,269.2,313.1,273.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q9UJY1","Heat shock protein beta-8 [OS=Homo sapiens]",5,1,1,1,196,21.6,5.12,1.76,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","HSPB8","ENSG00000152137","IL-18 signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy","HSF1-dependent transactivation","",0.593,0.809,0.678,0.894,0.651,0.29219790594662,1,1,1,0.511163815578367,76.9,105,88,129.7,116,84.4,93.4,64.2,75.9,110.3,103.5,96.6,85.4,99.5,86.8,155,113.3,128,120.1,89.5,114.4,121.6,83.3,59.3,16.9,11.6,13.8,20,18.8,17.5,15.5,18,15.7,28.1,20.5,23.2,21.8,16.2,20.7,22,15.1,10.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8NG27","E3 ubiquitin-protein ligase Praja-1 [OS=Homo sapiens]",12,5,5,4,643,71,5.17,6.83,"protein metabolism;other metabolic processes","other cell component","other molecular function","PJA1","ENSG00000181191","TGF-beta signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation","",0.597,0.752,0.647,0.661,0.62,0.00110377647193986,0.0849151258239964,0.00591477858664181,3.59880421767385E-3,1.02470505405636E-3,83.7,105.5,90.8,140.3,92.7,87,83,83,94.7,113,104.7,97,104.6,90.1,85.3,143.1,129.3,139.2,91.9,95.2,88.9,87.2,86.3,83.4,98.7,98.6,112.5,134.3,124.4,115.3,124.3,107,101.4,170,153.6,165.4,109.3,113.1,105.7,103.6,102.6,99,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q92802-1","NEDD4-binding protein 2-like 2 [OS=Homo sapiens]",4,3,3,3,583,67.4,6.39,2.14,"developmental processes;other biological processes","nucleus;other cell component","other molecular function","N4BP2L2","ENSG00000244754","","","",0.6,0.667,0.669,0.646,0.654,6.36742700038662e-06,5.4566932882414e-05,4.19426456088285e-05,7.6279195442326e-06,2.75286087599191E-5,85,94.5,94.8,141.7,91.5,92.6,87.1,84.1,84.9,94.4,95.3,92.9,94.7,92.6,97.4,143.8,140.1,141.6,91.4,92.1,83.3,92.5,90.4,101.7,165.4,159.7,161.2,179.3,181,176.4,179.8,175.9,184.9,273.1,266,268.9,173.6,174.9,158.2,175.7,171.7,193.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q96MT1","RING finger protein 145 [OS=Homo sapiens]",1,1,2,1,663,75.6,6.84,0,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","RNF145","ENSG00000145860","","","",0.602,0.732,0.614,0.49,0.664,0.526598365522098,1,0.416641217357879,0.0408699728692529,0.576124857665911,88.1,107.1,89.8,146.2,71.6,97.2,89.2,78,118.2,108.4,111,102.6,72.1,90.9,106.1,151.6,148,122,53.2,84.6,72.5,111.4,98.4,81.9,13.8,12,18.2,16.7,17.1,15.8,11.1,14,16.4,23.4,22.8,18.8,8.2,13.1,11.2,17.2,15.2,12.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P20648","Potassium-transporting ATPase alpha chain 1 [OS=Homo sapiens]",5,5,27,1,1035,114,5.81,64.5,"transport;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","ATP4A","ENSG00000105675","Secretion of hydrochloric acid in parietal cells","Ion transport by P-type ATPases","Oxidative phosphorylation; Metabolic pathways; Collecting duct acid secretion; Gastric acid secretion",0.602,0.913,0.937,0.793,0.984,1,1,1,1,1,69.1,104.8,107.5,114.7,91,112.9,69.3,65.7,97.7,106.6,105.1,87.4,107.8,111.6,76,115.1,81,115.3,82.4,91.2,105.4,113.3,165.9,103.3,63.2,60,89.1,97.3,95.9,79.8,98.3,101.9,69.3,105,73.9,105.2,75.1,83.2,96.2,103.3,151.3,94.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O15318","DNA-directed RNA polymerase III subunit RPC7 [OS=Homo sapiens]",14,3,3,3,223,25.9,4.63,5.5,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","POLR3G","ENSG00000113356","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",0.603,0.744,0.658,0.748,0.734,0.0152641010008851,0.473104305236594,0.0875686373563751,0.320946490593578,0.10791823176376,80.6,99.5,88,133.7,100,98.2,79.7,72.1,81.8,98.3,102.5,98.2,97.3,87,80.3,164.1,132.2,126.1,98.1,98.9,103.3,97.1,70.6,112.4,55.4,50.1,56.9,68.3,71.2,68.3,67.7,60.5,55.8,114,91.9,87.7,68.2,68.7,71.8,67.5,49,78.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","A6NHQ2","rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 [OS=Homo sapiens]",10,4,13,1,334,34.8,10.35,37.65,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","FBLL1","ENSG00000188573","","","",0.605,0.937,1.031,1.046,0.843,0.733988613703838,1,1,1,1,66.4,103,113.2,109.9,114.9,92.6,64.5,67,85.1,103.8,100.9,111.7,114.1,85.8,125.8,110.7,102.3,119,62.2,138.9,115.9,93.4,111.4,87.6,14.3,14.8,18.9,23,22.4,24.8,25.3,19,27.9,24.6,22.7,26.4,13.8,30.8,25.7,20.7,24.7,19.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","O15156","Zinc finger and BTB domain-containing protein 7B [OS=Homo sapiens]",1,1,1,1,539,58,5.86,2.12,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB7B","ENSG00000160685","Ectoderm differentiation; Ectoderm differentiation","","",0.605,0.681,0.632,0.615,0.681,0.00188097024923098,0.0488475339309691,6.47236816381681E-3,0.00319780566983281,0.0155254689414061,86.1,97,90,142.4,87.6,97,84.6,87.8,88.4,98.1,101.8,98.9,91.7,82.3,99.8,147.3,116.5,145.2,89.3,87,90.1,98.9,99.8,92.6,52.4,54.3,54.7,60.7,63,61.2,56.8,50.9,61.8,91.2,72.1,89.8,55.3,53.8,55.8,61.2,61.7,57.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q7Z7L9-1","Zinc finger and SCAN domain-containing protein 2 [OS=Homo sapiens]",12,5,9,2,614,69.5,7.34,15.31,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZSCAN2","ENSG00000176371","","","",0.607,0.58,0.591,0.579,0.587,7.60867501201531e-05,1.70275195289014E-4,6.45613618506225e-05,7.18775328704886e-05,6.12514070931054e-05,92.4,88.3,89.9,152.1,88.1,89.3,95.2,85.2,91.2,86.3,96.8,87.1,88.8,92.2,82.4,149.1,150.2,156.2,87,96,86.8,88.2,95.3,86.1,157.9,141.3,151.2,143.1,160.6,144.5,147.2,153,136.7,247.3,249.1,259,144.3,159.3,143.9,146.3,158.1,142.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P21860-1","Receptor tyrosine-protein kinase erbB-3 [OS=Homo sapiens]",1,1,1,1,1342,148,6.55,2.36,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function","ERBB3","ENSG00000065361","Heart development; Glioblastoma signaling pathways; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Apoptosis-related network due to altered Notch3 in ovarian cancer; EGFR tyrosine kinase inhibitor resistance; ErbB signaling pathway","","EGFR tyrosine kinase inhibitor resistance; MAPK signaling pathway; ErbB signaling pathway; Calcium signaling pathway; PI3K-Akt signaling pathway; Proteoglycans in cancer; MicroRNAs in cancer",0.608,0.746,0.677,0.591,0.604,0.00723754867655625,0.557892495697639,0.0801163765284272,0.00760581356236543,0.00498178675784373,86.3,106,96.1,142,83.9,85.7,86.8,75.8,86.8,119.7,104.6,106.6,95.8,98.3,96.7,152.2,142.8,140.8,99,67.8,84.4,68.6,87,86.2,43.8,38.3,43.8,60.5,52.8,53.8,48.4,49.7,48.8,76.9,72.2,71.1,50,34.3,42.6,34.7,43.9,43.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96QE5","Transcription elongation factor, mitochondrial [OS=Homo sapiens]",6,1,1,1,360,41.7,9.32,2.63,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","enzyme regulator activity","TEFM","ENSG00000172171","","","",0.61,0.802,0.697,0.625,0.712,0.365077172811481,1,1,0.612255529025752,1,82.3,108.3,94,134.9,84.4,96.1,69.3,82.4,96.4,108.4,93.8,121.3,86,98.5,94.1,110.1,141.1,135.1,64.1,84.5,122.7,96.2,104.6,91.1,18.4,21.8,25.5,28.7,24.9,32.1,22.8,26.1,24.9,29.2,37.4,35.8,17,22.4,32.5,25.5,27.7,24.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","O95294-1","RasGAP-activating-like protein 1 [OS=Homo sapiens]",1,1,1,1,804,90,6.51,0,"signal transduction;other biological processes","cytosol","enzyme regulator activity;other molecular function","RASAL1","ENSG00000111344","Ras signaling","Regulation of RAS by GAPs","Ras signaling pathway",0.612,0.98,0.61,0.788,0.881,1,1,1,1,1,75.4,120.7,75.1,123.2,97.1,108.5,72,127.7,67.6,125.5,115.2,77.7,71.7,106.8,66,117.6,116,124.9,92.7,86.7,121.6,103.6,119.3,87.7,9.4,16.7,8.8,16.4,15,10.1,9.3,13.9,8.6,15.3,15.1,16.3,12.1,11.3,15.9,13.5,15.6,11.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8NBP7-1","Proprotein convertase subtilisin/kexin type 9 [OS=Homo sapiens]",12,5,6,5,692,74.2,6.61,9.64,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","PCSK9","ENSG00000169174","PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Metabolic pathway of LDL, HDL and TG, including diseases; Familial hyperlipidemia type 2","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; LDL clearance; VLDLR internalisation and degradation","Cholesterol metabolism",0.613,0.684,0.699,0.629,0.718,2.31643638312206E-3,0.048926086173523,0.0166874947682558,0.00376901536578602,0.0189044715322799,84.6,94.4,96.6,138.2,86.9,99.2,82.6,83.5,90.2,93.2,89.5,112.8,100.4,95.3,86.3,135.2,143.6,136.3,82.2,93.8,85.7,87.4,104.2,97.9,37,37.5,40.5,41.8,40.2,50.6,45.1,42.8,38.7,60.7,64.4,61.2,36.9,42.1,38.5,39.2,46.8,43.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UHJ3-1","Scm-like with four MBT domains protein 1 [OS=Homo sapiens]",3,2,2,2,866,98.1,6.21,0,"cell organization and biogenesis;other biological processes","nucleus","other molecular function","SFMBT1","ENSG00000163935","","","",0.614,0.544,0.888,0.724,0.908,1,1,1,1,1,78.7,69.8,113.9,128.2,92.9,116.5,79.1,108.4,72.6,99.6,70.1,63.4,76,116.4,114.4,135.4,128.9,76.6,85,93.3,134.6,78.5,150.6,117,10.1,13.8,9.3,12.7,9,8.1,9.7,14.9,14.6,17.3,16.4,9.8,10.9,11.9,17.2,10,19.2,14.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q96L15","Ecto-ADP-ribosyltransferase 5 [OS=Homo sapiens]",3,1,1,1,291,32,8.27,0,"protein metabolism;other metabolic processes","non-structural extracellular","other molecular function","ART5","ENSG00000167311","","","",0.616,0.724,0.644,0.535,0.625,0.673094411371162,1,0.585394868802685,0.31077898286876,0.411704201217977,89.2,104.9,93.2,144.8,77.4,90.5,89.8,111.4,73.4,108.1,105.6,102.1,53.6,123.5,93.8,128.2,171.7,145.7,77.9,70.5,87.9,101.9,63.8,91.1,12.7,15.7,10.4,15.3,14.9,14.4,7.6,17.4,13.3,18.1,24.3,20.6,11,10,12.4,14.4,9,12.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","O60729-1","Dual specificity protein phosphatase CDC14B [OS=Homo sapiens]",2,1,1,1,498,56.8,9.03,1.72,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CDC14B","ENSG00000081377; ENSPPYG00000019417; ENSPTRG00000021155","Cell cycle; Cell cycle","MAPK6/MAPK4 signaling","Cell cycle",0.616,0.688,0.724,0.692,0.752,0.0397054319781401,0.457782242728943,0.544675589803839,0.334310789608783,0.374228387382022,82.7,92.3,97.2,134.1,92.9,100.9,88.8,82.4,78.6,103.7,90.8,92,91.3,96.8,108.6,133.7,142.1,107.2,106.7,92.6,90,100.5,85,109.3,54.8,50.9,48.5,64,56,56.8,56.4,59.8,67.1,82.5,87.8,66.2,65.9,57.2,55.6,62.1,52.5,67.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P01130","Low-density lipoprotein receptor [OS=Homo sapiens]",10,8,10,8,860,95.3,5.05,17.03,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LDLR","ENSG00000130164","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M signaling pathway; PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Lipid particles composition; Wnt signaling pathway and pluripotency; Statin inhibition of cholesterol production; Bile acids synthesis and enterohepatic circulation ; Metabolic pathway of LDL, HDL and TG, including diseases; Orexin receptor pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; DNA damage response (only ATM dependent)","Cargo recognition for clathrin-mediated endocytosis; Retinoid metabolism and transport; LDL clearance; Chylomicron clearance","Endocytosis; Ovarian steroidogenesis; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Cushing syndrome; Bile secretion; Cholesterol metabolism; Toxoplasmosis; Hepatitis C; Lipid and atherosclerosis",0.617,0.565,0.556,0.586,0.603,2.56267852273252E-5,1.74793842940786e-05,6.64354282412578e-06,7.6279195442326e-06,1.72564585339806E-5,94.2,86.3,85,152.8,89.6,92.2,99.3,91,93.3,89.7,82.1,85.4,84.4,83.2,84.2,151.2,151.3,161.8,89.2,87.4,88.7,91.3,86,100.4,437.9,401.4,411.7,395.8,362.1,376.9,372.2,367,371.4,666.7,667.6,713.6,393.4,385.6,391.3,402.9,379.1,443,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q6NT16","MFS-type transporter SLC18B1 [OS=Homo sapiens]",2,1,1,1,456,48.8,5.22,0,"transport","other membranes","transporter activity","SLC18B1","ENSG00000146409","","","",0.617,0.984,0.733,0.903,0.96,0.728130383967327,1,1,1,1,71.3,113.6,84.7,115.4,104.3,110.8,78.6,71,75.3,120,75.8,122.9,89.4,92.9,64.1,121.9,130.8,89.9,112.4,104,110.1,117.1,82.6,141.4,10.1,9.2,9.7,15.5,9.8,15.8,11.5,12,8.3,15.7,16.9,11.6,14.5,13.4,14.2,15.1,10.7,18.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8TE02-1","elongator complex protein 5 [OS=Homo sapiens]",7,1,1,1,316,34.8,4.97,4.31,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","","ELP5","ENSG00000170291; ENSG00000288485","","HATs acetylate histones","",0.621,0.887,0.689,1.009,0.971,1,1,1,1,1,72,102.8,79.8,115.9,116.9,112.6,126.9,72,68.2,104.5,80.2,102.9,135.5,52.7,79.9,116,66.7,146.9,120.1,104.3,117,112.7,78.9,114.6,18,10.2,9.6,14.8,11.4,14.6,19.2,7.5,11.3,16.4,9.4,20.8,17,14.8,16.6,15.9,11.2,16.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P07919","Cytochrome b-c1 complex subunit 6, mitochondrial [OS=Homo sapiens]",20,1,2,1,91,10.7,4.44,11.08,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","UQCRH","ENSG00000173660","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly","Respiratory electron transport","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",0.627,0.958,0.98,0.977,1.014,1,1,1,1,1,67.7,103.5,105.8,108,105.5,109.5,85.4,67,66.6,124.2,80.8,102.5,104.8,93.2,125.3,120.7,80.5,107,104.5,99.5,118.5,67.3,143.9,108.4,22.3,17.5,17.4,32.5,21.1,26.8,27.4,24.4,32.8,31.6,21.1,28,27.3,26,31,17.6,37.6,28.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q6PID6","Tetratricopeptide repeat protein 33 [OS=Homo sapiens]",22,3,3,3,262,29.4,5.44,3.71,"","","","TTC33","ENSG00000113638","","","",0.629,0.671,0.669,0.629,0.55,0.0200893489775616,0.0732634364793443,0.0322212405730246,0.030638907859388,1.64645151546125E-3,91,97.1,96.8,144.7,90.9,79.6,86.3,90.3,101.8,96.4,91.1,103.8,81.2,105.3,96.1,129.2,158.8,143.7,87.9,90.3,107.8,71.7,79.1,79.2,46.4,48.6,54.8,51.9,49,55.8,43.7,56.6,51.7,69.5,85.4,77.3,47.3,48.6,58,38.5,42.5,42.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q8NH93","Olfactory receptor 1L3 [OS=Homo sapiens]",2,1,1,1,324,36.6,9.2,2.15,"signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","OR1L3","ENSG00000171481","","","Olfactory transduction",0.63,0.66,0.841,0.958,0.604,1,1,1,1,0.44236301595155,80.5,84.4,107.6,127.9,122.5,77.2,72,118.9,78.6,84.4,82.3,79.8,105,99.1,142.9,85.6,149.7,124.8,119.5,131.9,108.4,75.4,54.1,87.6,26.7,44.1,29.1,31.3,30.5,29.6,38.9,36.8,53,31.7,55.5,46.3,44.3,48.9,40.2,28,20,32.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P52926-1","high mobility group protein HMGI-C [OS=Homo sapiens]",38,3,9,3,109,11.8,10.62,22.47,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGA2; HMGI-C","ENSAMEG00000027432; ENSANAG00000035456; ENSBIXG00000020345; ENSBIXG00005009212; ENSBTAG00000044118; ENSCANG00000031318; ENSCATG00000038158; ENSCCAG00000025036; ENSECAG00000040252; ENSG00000149948; ENSGGOG00000036483; ENSMFAG00000043308; ENSMNEG00000035555; ENSPANG00000013190; ENSPCOG00000002104; ENSPCTG00005002631; ENSPTRG00000005184; ENSRBIG00000039558; ENSRFEG00010001959; ENSRROG00000032427","Mesodermal commitment pathway; Mesodermal commitment pathway; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Orexin receptor pathway","Formation of Senescence-Associated Heterochromatin Foci (SAHF)","Transcriptional misregulation in cancer; MicroRNAs in cancer",0.63,0.803,0.874,0.932,0.901,0.432254748578706,1,1,1,1,73.6,93.8,102,116.7,108.8,105.2,72.6,86.8,69.3,96.6,92.6,87.9,100.7,98.7,113.7,134.4,115.3,78.4,107.4,114.5,103.1,103.9,100.8,123.5,286,341.7,273,380.2,364.5,346.1,396.5,388.7,447.6,529.3,453.8,308.7,422.8,450.8,406,409,396.9,486.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9P2Q2","FERM domain-containing protein 4A [OS=Homo sapiens]",3,3,3,3,1039,115.4,8.87,2.24,"other biological processes","cytoskeleton;other cell component","other molecular function","FRMD4A","ENSG00000151474","","","",0.631,0.749,0.724,0.841,0.748,0.245563412436836,0.805555786978447,0.90416701497326,0.775109890855915,0.615428420730441,80.6,95.8,92.6,127.9,107.5,95.7,79.6,90.4,80.7,98.2,95.9,81.5,92.8,103.2,92.2,128.1,127.3,147,127.8,63.3,107.6,99.3,95.8,89.3,10.3,11.6,10.4,12.7,12.4,10.5,12,13.3,11.9,16.5,16.4,18.9,16.5,8.2,13.9,12.8,12.3,11.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H5J0","Zinc finger and BTB domain-containing protein 3 [OS=Homo sapiens]",5,2,2,2,574,61.8,5.62,5.48,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB3","ENSG00000185670","","","",0.632,0.71,0.78,0.626,0.697,0.0110852010317067,0.132208935309506,0.261730383529992,6.7995018416887E-3,0.144862610768246,85.3,95.8,105.3,135,84.5,94.1,74.6,89.2,87.1,101.4,86.6,97.9,107.5,107.8,91.5,135,141.7,137.9,88.4,66.3,86.3,92.5,112.1,96.1,61.2,73.2,71.5,83.3,71.1,80.4,88.3,88.5,75.1,110.8,116.3,113.2,72.6,54.5,70.9,76,92.1,78.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H2J7","Sodium-dependent neutral amino acid transporter B(0)AT2 [OS=Homo sapiens]",2,1,1,1,730,81.8,5.19,3.31,"transport","plasma membrane;other membranes","transporter activity","SLC6A15","ENSG00000072041","Nuclear receptors meta-pathway; NRF2 pathway","Na+/Cl- dependent neurotransmitter transporters; Amino acid transport across the plasma membrane","",0.633,0.816,0.633,0.726,0.749,0.521511573504818,1,0.418172714082925,1,1,83.4,107.4,83.3,131.7,95.6,98.6,69,80.7,110.4,90.8,104,116.9,80.7,78.4,83.2,112.4,127.4,137.3,128.4,92.5,88.4,95.4,82.1,122,31.2,36.4,49.9,41,47,52.8,36.4,35.4,37.6,50.8,57.6,62,58,41.8,39.9,43.1,37.1,55.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96SZ4-1","Zinc finger and SCAN domain-containing protein 10 [OS=Homo sapiens]",24,12,20,12,725,80.3,8.81,39.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZSCAN10","ENSG00000130182","","Transcriptional regulation of pluripotent stem cells","",0.635,0.693,0.641,0.633,0.645,1.19390880019438e-05,0.00018580138859872,2.02935528188339e-05,1.00146927998612E-5,1.86485642139786e-05,89.8,97.9,90.5,141.3,89.4,91.1,88.9,92.7,89.5,102.1,97.6,96.5,93.2,89.7,90.2,140.8,129,141.1,93.7,87.9,89.2,90.9,96.8,90.2,622.7,648.9,626.3,714.4,682.9,675.6,652.7,627.7,631.6,986,903.2,987.8,655.7,615.4,624.2,636,677.3,631.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O95405-1","Zinc finger FYVE domain-containing protein 9 [OS=Homo sapiens]",2,1,1,1,1425,156.3,5.01,0,"transport;signal transduction","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ZFYVE9","ENSG00000157077","TGF-beta signaling pathway; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling","","Endocytosis; TGF-beta signaling pathway",0.636,0.695,0.696,0.659,0.509,0.613685887369939,1,0.971236632156034,0.807885498948285,0.323748658164094,91,99.5,99.5,143,94.2,72.8,96.1,88.1,80.8,96.2,92.3,122.6,96.3,96.5,85.6,140.4,131.6,138.4,123.3,91.2,68.2,63.1,118.8,70.4,20.2,18.5,17,20.2,19.4,25.7,20.2,20.2,18,29.5,27.6,29,25.9,19.1,14.3,13.2,24.9,14.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UHL0-1","ATP-dependent RNA helicase DDX25 [OS=Homo sapiens]",8,2,10,1,483,54.7,6.28,20.64,"other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX25","ENSG00000109832","","","",0.638,0.696,0.63,0.633,0.675,0.441761747059374,1,0.611765874222913,0.464663572300217,1,89.6,97.7,88.5,140.4,88.9,94.8,88.2,72.8,94.5,108.6,85,96.2,62.4,87.2,119.5,123.6,156.6,138.3,88.6,87.6,79.4,78.6,93.3,139.6,15.3,12.6,16.4,18.9,14.8,16.7,10.8,15.1,20.7,21.5,27.2,24,15.4,15.2,13.8,13.6,16.2,24.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UPW6","DNA-binding protein SATB2 [OS=Homo sapiens]",2,2,2,2,733,82.5,6.9,4.02,"cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SATB2","ENSG00000119042","Rett syndrome causing genes; Transcription co-factors SKI and SKIL protein partners","SUMOylation of chromatin organization proteins; RUNX2 regulates osteoblast differentiation","",0.638,0.662,0.517,0.627,0.631,0.072319940181125,0.168381806501454,0.0119874216919133,0.0259095313348919,0.0188427914548541,94,97.5,76.1,147.2,92.4,92.8,103,94,93.3,91.5,107.5,97.6,76.2,73.5,98.7,147.8,147.3,137,82.6,93,92.4,92.9,72.3,99.4,61.4,56,55.6,54.5,64.1,58.2,45.4,43.8,58.8,88.1,87.8,81.7,49.3,55.5,55.1,55.4,43.1,59.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96KG7-1","Multiple epidermal growth factor-like domains protein 10 [OS=Homo sapiens]",1,1,1,1,1140,122.1,6.87,2.93,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","MEGF10","ENSG00000145794","","","",0.638,0.652,0.58,0.566,0.649,0.679706908947598,0.704493669834864,0.256773261849011,0.214265282789066,0.574054923633198,93.7,95.7,85.2,146.9,83.2,95.3,107.4,89.8,95.4,97.4,80.1,100.9,97.2,86.7,68.4,149.5,125.2,151,84.6,65.5,105.1,97,123.8,75.1,36.4,30.4,32.3,33,27.1,34.2,32.9,29.4,23.2,50.6,42.4,51.1,28.7,22.2,35.6,32.8,41.9,25.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q70EK9","Ubiquitin carboxyl-terminal hydrolase 51 [OS=Homo sapiens]",7,3,3,3,711,79.7,8.37,5.32,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","other cell component","other molecular function","USP51","ENSG00000247746","","","",0.641,0.804,0.945,0.689,0.739,0.393903262125219,1,1,1,1,79.8,100.1,117.7,124.5,85.8,92.1,80.5,93.6,70.1,101,103.2,99.7,74.7,118.8,127.3,126.8,108.2,125.7,86.5,86.4,100.1,92.9,117.3,87.2,31.4,36.5,27.3,39.4,40.2,38.9,29.1,46.3,49.6,49.4,42.2,49,33.7,33.7,39,36.2,45.7,34,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P31641","Sodium- and chloride-dependent taurine transporter [OS=Homo sapiens]",4,2,8,2,620,69.8,7.39,24.32,"transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC6A6","ENSG00000131389","Nuclear receptors meta-pathway; NRF2 pathway","Na+/Cl- dependent neurotransmitter transporters; Amino acid transport across the plasma membrane","",0.641,0.796,0.767,0.751,0.725,7.60867501201531e-05,0.0343854982611836,0.00607616494924313,0.00447849004646498,0.000604165192284797,82.1,102.1,98.3,128.2,96.3,93,77.6,82.3,83.3,102.2,100,107.1,91.3,104.5,98.5,132.3,127.6,128.4,94.9,102.3,96.4,83.3,94.9,93.1,600,636,644.4,790.2,773.4,828.2,705.6,807.9,761.2,1022.6,986.3,992.8,733.8,791.1,745.5,644.2,733.6,719.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96F46","Interleukin-17 receptor A [OS=Homo sapiens]",4,2,2,2,866,96.1,5.21,2.5,"stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","IL17RA","ENSG00000177663","IL-17 signaling pathway","Interleukin-17 signaling","Cytokine-cytokine receptor interaction; IL-17 signaling pathway; Alcoholic liver disease",0.641,1.256,1.06,1.002,1.15,1,1,1,1,1,62.9,123.4,104.1,98.2,98.4,113,59.5,122.9,61.4,127.2,108.5,120.3,101.5,84.1,121.2,107,59.9,95.8,115.6,86.2,96,110.2,124.1,98.5,8.1,16.8,8.4,17.4,14.8,16.4,13.9,11.5,16.6,14.6,8.2,13.1,15.8,11.8,13.1,15.1,16.9,13.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q96KN1","Protein FAM84B [OS=Homo sapiens]",5,1,1,1,310,34.5,5.54,0,"","plasma membrane;other membranes;other cell component","","LRATD2","ENSG00000168672","","","",0.641,0.619,0.848,0.811,0.524,0.218115576177012,0.927119045659439,1,1,0.044881304043485,86.6,83.5,114.5,135.1,109.5,70.8,91.1,85.9,80.5,82.9,125.3,81.6,108.5,113.6,116.1,134,110.2,134.8,91.2,111.2,108.6,70.2,69.6,84.7,13.6,12.8,12,12.3,18.6,12.1,16.1,16.9,17.3,19.9,16.4,20.1,13.6,16.5,16.2,10.4,10.4,12.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","Q7Z494-1","Nephrocystin-3 [OS=Homo sapiens]",1,1,1,1,1330,150.8,6.76,2.08,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;other cell component","","NPHP3","ENSG00000113971","Joubert syndrome; Ciliopathies","Trafficking of myristoylated proteins to the cilium","",0.642,0.814,0.665,0.729,0.709,0.23682820571535,1,0.183011710126126,0.619344193841117,0.241292680785067,84.5,107.1,87.5,131.6,95.9,93.4,103.4,84.5,79.5,107,110.1,96,71.8,95.1,87.5,131.6,141.1,126.5,93.2,103.2,95.9,93.3,67.5,112.8,76,62.1,58.4,78.6,80.8,70.5,52.7,69.8,64.3,96.6,103.6,92.9,68.4,75.8,70.4,68.5,49.6,82.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","A2RUB1","Meiosis-specific coiled-coil domain-containing protein MEIOC [OS=Homo sapiens]",1,1,1,1,952,107.5,7.12,1.86,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","MEIOC","ENSG00000180336","","","",0.643,0.807,0.803,0.506,0.66,0.970943977219113,1,1,0.155364680117275,0.283128373065301,87.3,109.5,109,135.8,68.7,89.6,90,90.6,102.3,86,113.7,120.7,113.2,118.1,77.9,167.7,141,136.1,45.9,90.1,71.4,94.2,48,93.1,18.4,18.5,20.9,17.5,23.2,24.6,23.1,24.1,15.9,34.2,28.7,27.7,9.3,18.4,14.5,19.2,9.8,19,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q96EI5","Transcription elongation factor A protein-like 4 [OS=Homo sapiens]",10,1,1,1,215,24.6,5.2,0,"","nucleus","other molecular function","TCEAL4","ENSG00000133142","","","",0.643,0.751,0.84,0.828,0.795,0.617672360435971,1,1,1,0.980631358103052,79.4,92.8,103.7,123.5,102.3,98.2,76.6,71.8,88.6,91.9,89.5,85,100.8,100,84.9,235.4,119.1,85.8,121.4,78.7,98.7,94.7,77.5,99.6,47.5,44.5,55,57,55.5,52.8,62.5,62.1,52.7,146.1,73.9,53.3,75.4,48.8,61.2,58.8,48.1,61.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q16600","Zinc finger protein 239 [OS=Homo sapiens]",4,2,2,1,458,51.6,7.64,2.31,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF239","ENSG00000196793","","","",0.644,0.74,0.68,0.723,0.778,0.432275669553019,1,0.475100585715468,1,0.98641540611199,84.6,97.3,89.4,131.4,95,102.3,79.7,102.8,85.6,98.4,97.7,100.8,90.4,70,107.6,132.9,103.5,137.9,105.9,96.1,91.1,109.2,87,103.5,34.3,44.2,36.8,42.3,42,43.4,38.9,30.1,46.3,57.2,44.5,59.3,45.6,41.3,39.2,47,37.4,44.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P78324","tyrosine-protein phosphatase non-receptor type substrate 1 [OS=Homo sapiens]",12,4,5,4,504,54.9,6.98,7.62,"cell adhesion;stress response;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","SIRPA","ENSG00000198053","Prolactin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Male infertility","Neutrophil degranulation; Cell surface interactions at the vascular wall; Signal regulatory protein family interactions","Osteoclast differentiation",0.648,0.746,0.717,0.691,0.679,0.0291193866769923,0.556048008522687,0.158036916174399,0.0340424150671708,0.0804979841968728,86.7,99.9,96,133.9,92.5,90.9,90.4,88.7,86,99.9,102.2,105.3,98.3,98.2,91.5,144.9,107.5,137,94.6,76.6,97.4,95.3,92.9,93,129.3,126.9,123.1,143,146.2,150.7,140.7,140.5,130.9,207.2,153.8,195.9,135.3,109.5,139.3,136.3,132.9,133.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9BVK2-1","Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",3,1,4,1,526,60,9.14,5.9,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG8","ENSG00000159063","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG8 causes CDG-1h","N-Glycan biosynthesis; Metabolic pathways",0.648,0.878,0.988,0.909,0.527,1,1,1,1,0.972157427127214,78.5,106.4,119.8,121.2,110.2,63.9,49.5,132.9,67.7,85.8,91.7,115.3,86.3,103.2,150.2,86.6,177.3,104.5,95,161,87.4,55.1,43.3,107.3,7,18.9,9.6,12.2,13,16.3,12.2,14.6,21.3,12.3,25.1,14.8,13.5,22.8,12.4,7.8,6.1,15.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NRA2","Sialin [OS=Homo sapiens]",3,2,3,2,495,54.6,8.27,3.92,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","transporter activity","SLC17A5","ENSG00000119899","","Sialic acid metabolism; Organic anion transporters; Defective SLC17A5 causes Salla disease (SD) and ISSD","Lysosome",0.648,0.795,0.655,0.611,0.584,0.974894193789386,1,1,0.943164837329673,0.247239694794595,90.6,111.1,91.5,139.8,85.4,81.6,95.8,76.5,94.6,118,98.6,116.1,95.6,83.1,103.3,146,181.7,105.7,107.3,89.3,69,85.2,39,95.2,26.6,21.2,26.2,32.7,27.3,32.2,26.5,23,28.6,40.5,50.4,29.3,29.8,24.8,19.1,23.6,10.8,26.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H0C5","BTB/POZ domain-containing protein 1 [OS=Homo sapiens]",5,2,2,1,482,52.7,6.1,0,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","BTBD1","ENSG00000064726","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",0.649,0.715,0.771,0.692,0.898,1,1,1,1,1,82.4,90.8,97.9,127,87.9,114,88,99.7,65.9,96.9,125.4,65.6,104.5,96.4,124.7,65,137.8,135.5,93.8,97.3,63.2,94.6,121.6,124.1,11.4,12.9,8.5,12.5,16.2,8.5,13.5,12.4,16.1,8.4,17.8,17.5,12.1,12.6,8.2,12.2,15.7,16,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P16422","Epithelial cell adhesion molecule [OS=Homo sapiens]",33,8,43,8,314,34.9,7.46,60.57,"cell adhesion;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","EPCAM","ENSG00000119888","","Cell surface interactions at the vascular wall","",0.65,0.841,0.789,0.796,0.779,0.128921358835556,1,1,0.936673749741608,1,80.3,103.9,97.5,123.6,98.4,96.3,71.4,83.4,78.3,105.4,91.7,101.3,95,130.8,93.8,119.6,121.9,120.4,95.9,82.9,104.1,83.3,127,93.8,839.1,981.2,920.6,1238.7,1077.8,1190.8,1117.4,1538.1,1103.4,1406,1433.1,1416,1127.2,974.6,1224.1,979.6,1492.9,1103,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q92564","dcn1-like protein 4 [OS=Homo sapiens]",4,1,1,1,292,34,5.88,0,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","DCUN1D4","ENSG00000109184","","Neddylation","",0.65,0.961,1.007,0.861,1.15,0.0974739825593133,1,1,1,1,69.3,102.5,107.3,106.6,91.8,122.5,83,60.4,70.1,103.6,101.3,109.8,111.9,94,108.5,110.7,96.7,107.8,82.4,92.8,108.4,123.9,132.6,102.3,44.5,32.4,37.6,55.6,54.3,58.9,60,50.4,58.2,59.4,51.9,57.8,44.2,49.8,58.1,66.5,71.1,54.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P01112","GTPase HRas [OS=Homo sapiens]",55,8,36,1,189,21.3,5.31,57.96,"stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","HRAS","ENSG00000174775; ENSG00000276536","Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; Pathways affected in adenoid cystic carcinoma; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; IL-2 signaling pathway; Malignant pleural mesothelioma; Alzheimer's disease; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling","Regulation of RAS by GAPs; EPHB-mediated forward signaling; FCERI mediated MAPK activation; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Focal adhesion; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Salmonella infection; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",0.65,0.915,0.918,0.927,0.984,1,1,1,1,1,72.3,101.8,102.1,111.2,103.1,109.5,100.8,70.8,65.5,126.4,99.6,90.8,100,112.4,74.8,115.5,108.9,80.5,77.7,100.9,112.6,107.2,99.2,156.5,61.2,43,39.8,76.8,60.5,55.2,60.7,68.3,45.4,70.2,66.2,48.9,47.2,61.3,68.4,65.1,60.3,95.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NVM1","Protein eva-1 homolog B [OS=Homo sapiens]",32,2,2,2,165,18.4,4.73,5.98,"","other membranes","","EVA1B","ENSG00000142694","","","",0.651,0.745,0.612,0.76,0.509,1,1,1,1,1,91.3,104.5,85.9,140.3,106.6,71.4,91.6,121.7,26,89.5,104.8,122.9,86.2,58.3,131.8,94.6,162.8,140.7,121.7,106.9,101.4,66.4,101.1,71.6,11.1,14.7,3.1,10.8,12.7,14.8,10.4,7,15.9,11.4,19.7,17,14.7,12.9,12.2,8,12.2,8.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q9BRR3","Transmembrane protein 246 [OS=Homo sapiens]",2,1,1,1,403,46.6,7.59,2.54,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","PGAP4","ENSG00000165152","","","",0.651,0.869,0.708,0.64,0.824,1,1,1,1,1,83.3,111.1,90.5,127.9,81.9,105.3,93.3,83.1,82.8,111,126.9,70.4,90.4,118.4,71.4,127.7,88.3,139.3,63.7,81.8,101.6,105.2,145.8,99,16.1,14.3,14.3,19.1,21.9,12.1,15.6,20.4,12.3,22,15.2,24,11,14.1,17.5,18.1,25.2,17.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O43791","Speckle-type POZ protein [OS=Homo sapiens]",7,2,2,2,374,42.1,5.8,2.04,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SPOP","ENSG00000121067","mRNA processing; Hedgehog signaling pathway","Hedgehog 'on' state","Hedgehog signaling pathway",0.652,0.828,0.782,0.721,0.762,1,1,1,1,1,82.5,104.7,98.9,126.4,91.2,96.3,127.8,75.4,83.3,105.7,108.4,104.7,99.8,83.8,108,130.7,127.7,84.4,83,115.9,92,107.8,64.3,97.2,27.1,16,17.6,22.4,22.9,22.2,21.1,17.8,22.9,27.7,27,17.9,17.6,24.5,19.5,22.8,13.6,20.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q96EW2-1","HSPB1-associated protein 1 [OS=Homo sapiens]",2,1,1,1,488,55.1,5.6,0,"","other cell component","other molecular function","HSPBAP1","ENSG00000169087","","","",0.652,0.905,0.687,0.65,0.702,0.507880487883325,1,1,0.316968249243908,0.721640185145334,85.2,118.2,89.7,130.5,84.8,91.6,75.2,101.8,83.5,115.9,111.9,117.8,88,125.2,85.7,131.4,128,111.7,64.2,83.1,101,89.8,102.9,83,24.7,33.5,27.5,38.1,36.8,38.8,28.9,41.2,28.2,43.2,42.1,36.7,21.1,27.3,33.2,29.5,33.8,27.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q9P0K1","Disintegrin and metalloproteinase domain-containing protein 22 [OS=Homo sapiens]",1,1,1,1,906,100.4,7.2,1.92,"cell adhesion;protein metabolism;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM22","ENSG00000008277","","LGI-ADAM interactions","",0.655,0.833,0.564,0.581,0.554,1,1,0.584441705550271,0.389905029966313,0.172658181157059,93.8,119.4,80.8,143.4,83.2,79.4,89.2,83.5,126,113.4,130.9,100.6,107.9,73.9,76.8,148.6,135.6,136.2,64.7,106.8,79.1,97.6,53.8,75.4,45.5,42.6,64.3,57.9,66.8,51.3,55.1,37.7,39.2,75.8,69.2,69.5,33,54.5,40.4,49.8,27.5,38.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q16651","prostasin [OS=Homo sapiens]",6,2,2,2,343,36.4,5.85,5.03,"protein metabolism;other biological processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","PRSS8","ENSG00000052344","","Formation of the cornified envelope","",0.656,0.825,0.685,0.72,0.669,0.000897644444406875,0.255184615203064,0.00238503464627128,0.00356308404550001,1.88128559134268E-3,86.4,108.7,90.2,131.8,94.8,88.2,82,85.3,93.2,107.4,117,103.4,89.1,94.2,84.1,138.4,130.1,128.2,86.1,93.6,98.1,86,87.1,96.7,200.4,208.6,227.9,262.4,286,252.6,217.8,230.1,205.4,338.3,318.1,313.4,210.4,228.9,239.7,210.2,212.9,236.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P53816","HRAS-like suppressor 3 [OS=Homo sapiens]",16,2,2,2,162,17.9,7.99,6.45,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PLAAT3","ENSG00000176485","Ras signaling","Acyl chain remodelling of PC; Acyl chain remodelling of PS; Acyl chain remodelling of PE; Acyl chain remodelling of PI","Glycerophospholipid metabolism; Ether lipid metabolism; Arachidonic acid metabolism; Linoleic acid metabolism; alpha-Linolenic acid metabolism; Metabolic pathways; Ras signaling pathway; Regulation of lipolysis in adipocytes",0.658,0.765,0.712,0.718,0.697,0.0277679444719539,0.267054590627301,0.132736805471848,0.0821990234741479,0.0659962995364456,86.7,100.9,93.8,131.9,94.7,91.9,95.9,75.4,87.2,102.6,101.5,89,92.2,95.9,94.3,145,132.6,132.5,95.2,86.8,96.3,74.1,111.2,92.3,60.3,47.5,54.9,64.5,63.8,56,58,60.3,59.4,91.3,83.4,83.4,59.9,54.6,60.6,46.6,70,58.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P0DJD0","RANBP2-like and GRIP domain-containing protein 1 [OS=Homo sapiens]",20,32,91,1,1748,196.5,6.14,185.76,"transport;other biological processes","nucleus;other cell component","","RGPD1","ENSG00000187627","","","",0.659,0.826,0.659,0.547,0.676,0.276641416219464,1,0.16802013254095,0.0631968121212371,0.232063932615477,90.5,113.5,90.5,137.4,75.2,92.9,101.5,90.2,87.8,114,113.1,104.4,66.3,90.2,108.8,143.3,137,121.5,74.6,75,96.2,96.9,86.6,92.7,28.9,25.7,25,32.5,32.3,29.8,18.9,25.7,31,40.9,39.1,34.7,21.3,21.4,27.4,27.6,24.7,26.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q6NXG1-1","epithelial splicing regulatory protein 1 [OS=Homo sapiens]",9,6,12,5,681,75.5,6.68,22.13,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ESRP1","ENSG00000104413; ENSPPAG00000037294; ENSPTRG00000020430","","Signaling by BRAF and RAF1 fusions; FGFR2 alternative splicing","",0.66,0.775,0.769,0.695,0.658,1.19390880019438e-05,0.000672475226817548,6.34106686494754E-4,1.48302732398473E-5,7.78433956407871e-06,86.9,102,101.3,131.7,91.5,86.7,84.9,95.3,86.3,99.6,101.3,102,100.6,104.5,100.5,127.6,135.1,130.8,91.2,88.6,90.8,89.5,86.1,85.3,534.6,599.8,543.6,627.3,638,642.6,633.3,657.7,633.1,803.5,850.9,823.4,574,558.1,572,563.3,542.2,537,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P21741","Midkine [OS=Homo sapiens]",43,5,13,5,143,15.6,9.79,32.61,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;other molecular function","MDK","ENSG00000110492","Malignant pleural mesothelioma","NOTCH2 Activation and Transmission of Signal to the Nucleus; Signaling by ALK","",0.662,0.689,0.699,0.66,0.734,1.05867583446061E-3,7.00301154326218E-3,0.00796343314665814,0.00140013664120646,0.00696564776834852,89.4,93,94.4,135,89.1,99,88.6,93.6,84.9,91.2,98,92.2,109.6,87.2,93.5,129.5,133.8,137.7,86.8,93.3,88.3,93.4,98.1,100.1,447.2,472.7,428.7,460.4,494.9,465.3,553.2,440.4,472.1,653.5,675.2,695,438.3,471.1,445.7,471.4,495.4,505,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H0V1","Transmembrane protein 168 [OS=Homo sapiens]",2,1,1,1,697,79.7,8.03,2.42,"","other membranes;ER/Golgi","","TMEM168","ENSG00000146802","","","",0.663,0.613,0.791,0.756,0.694,1,1,1,1,1,88.1,81.4,105.1,132.8,100.4,92.2,86.7,127.4,80.4,76.2,80.1,97.9,103.5,131.4,53.4,120,132.6,130.8,98.8,94.8,119.6,90.8,92.5,83.2,12.7,18.6,11.8,11.2,11.7,14.3,15.1,19.2,7.8,17.6,19.4,19.1,14.5,13.9,17.5,13.3,13.5,12.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q6IQ21","Zinc finger protein 770 [OS=Homo sapiens]",5,3,3,3,691,80,9.55,5.33,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF770","ENSG00000198146","","Generic Transcription Pathway","",0.663,0.825,0.796,0.644,0.834,0.565385784464391,1,1,0.856031774167208,1,83.6,103.9,100.3,126,81.2,105.1,71.5,81.4,94.1,104.5,101.2,95,88.1,107.5,97.7,122.8,112.1,124.6,79.1,78.3,103.5,102.4,155.3,80.8,64.8,73.9,85.4,94.8,91.8,86.2,80,97.6,88.7,111.4,101.7,113.1,71.8,71,93.9,92.9,140.9,73.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NTW7","Zinc finger protein 64 homolog, isoforms 3 and 4 [OS=Homo sapiens]",6,4,4,4,645,72.2,8.43,6.93,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZFP64","ENSG00000020256","","","",0.664,0.721,0.664,0.67,0.676,0.0150638222192789,0.126895178349675,0.0842461117108949,0.0270247684452518,0.0179271578905788,90.6,98.4,90.7,136.5,91.5,92.3,77.3,89.6,99.6,100.5,97.3,93.7,114.4,87.6,89.7,133.2,139.9,135,90.4,86.9,96.9,81.6,91.2,95.1,122.9,142.5,158.4,159.8,154.8,149,182,139.4,142.6,211.9,222.5,214.7,143.8,138.2,154.1,129.9,145.1,151.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O14994","Synapsin-3 [OS=Homo sapiens]",5,2,2,2,580,63.3,9.39,2.45,"cell-cell signaling;transport;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","SYN3","ENSG00000185666","Synaptic vesicle pathway","Serotonin Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle","",0.665,0.684,0.708,0.643,0.782,0.0844104943826316,0.155743196297194,0.0767040919442534,0.0317235461685304,0.191243152404342,89.1,91.5,94.7,133.9,86.1,104.7,97.4,90.6,90.2,96.6,93.1,88.5,105.3,71.8,96.3,136.2,151,126.8,87.5,81.7,88.3,106.5,108,84.1,95,88.3,88,94.2,90.8,86.3,102.7,70,94,132.8,147.2,123.7,85.4,79.7,86.1,103.9,105.3,82,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q96SA4","Serine incorporator 2 [OS=Homo sapiens]",2,1,1,1,455,50.7,6.19,1.72,"other metabolic processes;other biological processes","other membranes","","SERINC2","ENSG00000168528","","Serine biosynthesis","",0.665,0.825,0.74,0.751,0.691,0.527968185035587,1,1,1,0.153118643238507,85.5,105.9,95,128.4,96.5,88.7,96.8,85.8,84.9,106.3,97.4,110.2,89,95.4,119.6,128.9,110.8,140.6,86.3,96.9,110.2,89,57.6,94.3,34.5,30.5,30.2,37.8,34.7,39.2,31.6,33.9,42.5,45.9,39.4,50,30.7,34.5,39.2,31.7,20.5,33.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q96JQ2","Calmin [OS=Homo sapiens]",2,2,2,2,1002,111.6,4.94,0,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;nucleus;other cell component","cytoskeletal activity","CLMN","ENSG00000165959","Vitamin D receptor pathway","","",0.666,0.716,0.719,0.763,0.635,0.782675614064924,0.889071246582176,0.716218318161664,0.603776517885038,0.151146683741646,88.8,95.5,95.9,133.4,101.7,84.7,117.4,89.1,89.8,107.4,82.4,96.7,91,97.6,97.1,139.9,117.6,135,106.8,77.4,102.9,85.7,99.1,67.2,40.2,30.5,30.8,36.8,28.2,33.1,31.2,33.5,33.3,47.9,40.3,46.2,36.6,26.5,35.3,29.4,34,23,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q8IXQ4","GPALPP motifs-containing protein 1 [OS=Homo sapiens]",2,1,2,1,340,38.1,5.41,2.83,"","","","GPALPP1","ENSG00000133114","","","",0.666,1.053,0.859,0.848,0.912,0.915198516995591,1,1,1,1,74.9,118.4,96.5,112.4,95.3,102.5,79,73,70.9,89,115.3,124.9,94,93.9,96.1,164.7,109.5,71.9,122.7,92.9,89.8,120.4,99.9,92.1,113.6,105,102.1,128.1,166,179.7,135.3,135.2,138.3,237,157.6,103.5,176.5,133.7,129.2,173.3,143.7,132.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UNK9","Protein angel homolog 1 [OS=Homo sapiens]",4,2,2,2,670,75.2,4.82,5.81,"RNA metabolism OR transcription;other metabolic processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","ANGEL1","ENSG00000013523","","","",0.667,0.786,0.782,0.842,0.632,0.634909589164505,1,1,1,0.867290980839833,84.9,100.1,99.6,127.4,107.3,80.6,73.2,101.9,83,97.9,98.8,91.2,77.3,113.5,97.3,104.3,142,124.5,102.5,106.4,104.9,77.1,78.8,125.5,21.1,29.4,23.9,28.2,28.5,26.3,22.3,32.7,28.1,30,40.9,35.9,29.5,30.7,30.2,22.2,22.7,36.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UHC7","E3 ubiquitin-protein ligase makorin-1 [OS=Homo sapiens]",12,3,4,3,482,53.3,5.14,9.9,"protein metabolism;other metabolic processes","cytosol","other molecular function","MKRN1","ENSG00000133606","","Regulation of PTEN stability and activity; Antigen processing: Ubiquitination & Proteasome degradation; AKT phosphorylates targets in the cytosol","",0.667,0.767,0.739,0.664,0.714,0.185375491864275,0.577789381964065,0.362783233791159,0.185731930728864,0.0538368851547817,87.9,101.2,97.4,131.8,87.6,94.1,113.1,86.8,81.9,94.3,101,99.9,99.8,96.2,93.3,128.1,139.9,130.2,86.5,108.1,85.3,93,69.4,92.9,114.3,87.7,82.8,95.3,102.1,101,100.9,97.2,94.3,129.5,141.4,131.6,87.4,109.3,86.2,94,70.1,93.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P41134","DNA-binding protein inhibitor ID-1 [OS=Homo sapiens]",28,3,3,3,155,16.1,6.99,7.97,"cell adhesion;developmental processes;signal transduction;other biological processes","cytoskeleton;ER/Golgi;nucleus","other molecular function","ID1","ENSG00000125968","Neural crest differentiation; Vitamin D receptor pathway; miR-517 relationship with ARCN1 and USP1; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Hfe effect on hepcidin production; Epithelial to mesenchymal transition in colorectal cancer; Orexin receptor pathway; ID signaling pathway","NGF-stimulated transcription; Oncogene Induced Senescence","Rap1 signaling pathway; TGF-beta signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells",0.668,0.845,0.681,0.55,0.523,0.000517461756393307,0.373732251740361,0.00272135928603936,6.37683782236762e-05,3.47730633961401e-05,93.9,118.8,95.8,140.6,77.4,73.5,95.9,79.9,93.7,125.1,118.5,114,95.5,94.2,97.6,155.9,140.3,132.5,76.5,77.2,78.4,73.3,80,71.3,245.8,204.8,240.2,320.7,303.8,292.3,244.9,241.4,250.3,399.5,359.6,339.7,196.1,197.8,201.1,187.9,205.2,182.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y546","Leucine-rich repeat-containing protein 42 [OS=Homo sapiens]",7,3,3,3,428,48.5,7.46,8.42,"","","","LRRC42","ENSG00000116212","","","",0.668,0.703,0.673,0.592,0.65,1.51164021496858E-4,1.49983387979783E-3,0.000213300950551603,3.7709873698362e-05,6.63771308757244e-05,93.6,98.4,94.2,140,82.8,91.1,93.8,87.9,96.3,98.6,96.3,103.7,86,94.4,95.1,139,140.4,145.3,83,82.4,91,82.9,91.3,92.6,184.4,172.8,189.2,193.8,189.3,203.7,169,185.6,186.8,273.3,275.9,285.6,163.2,161.9,179,163,179.4,182,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q03393","6-pyruvoyl tetrahydrobiopterin synthase [OS=Homo sapiens]",23,3,3,3,145,16.4,6.68,6.17,"other metabolic processes;developmental processes","cytosol;mitochondrion;other cell component","other molecular function","PTS","ENSG00000150787","","Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors",0.67,0.672,0.694,0.65,0.662,1.08214031869696E-4,0.000316264059918722,0.00028828646238708,5.39735375524297E-5,6.89065716647204e-05,92.4,92.8,95.8,138,89.7,91.3,92.2,94.4,90.3,89.4,92.6,99.3,89.8,98.9,95.6,135.9,137.7,144.3,84.4,89.5,92.9,91.1,86.1,95.6,123.8,126.8,121.2,120,124.3,133.3,120.5,132.8,128.3,182.4,184.8,193.7,113.4,120.2,124.7,122.3,115.5,128.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NXG0-1","Centlein [OS=Homo sapiens]",5,6,6,6,1405,161.5,8.15,16.91,"","","","","","","","",0.671,0.644,0.622,0.65,0.616,0.0178085060992463,0.0366367969452931,0.0211972062151203,0.0106216312524811,0.0079995043733187,95.8,91.9,88.8,142.8,92.8,87.9,100,95.3,85,91.2,97.4,91.5,109,81.5,88.4,140.1,142.9,142.1,94.2,83.2,92.4,87.5,79,99.2,211.7,201.7,179.9,192.9,206.1,193.6,230.7,172.4,187,296.4,302.3,300.7,199.3,176,195.4,185.1,167.1,209.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q53HI1","protein unc-50 homolog [OS=Homo sapiens]",2,1,2,1,259,30.4,9.47,4.67,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity","UNC50","ENSG00000115446","","","",0.671,0.832,0.84,0.747,0.706,2.06311292131063E-4,0.0496244174299988,0.0395742071907639,0.00212184577452536,0.000754958710294466,83.9,104.1,105.1,125.1,93.4,88.4,81.3,88.2,84.3,104.6,96,107.6,96.9,105.6,106.8,123.4,130.5,125.7,93.8,95.4,90.9,84.3,88.8,95.9,150.1,162.7,155.6,192.9,177.2,198.6,178.7,194.9,197.1,227.7,240.7,231.9,173.1,176,167.7,155.5,163.8,177,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UNL4-1","inhibitor of growth protein 4 [OS=Homo sapiens]",12,3,3,3,249,28.5,7.62,7.35,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ING4","ENSCATG00000030917; ENSCJAG00000008004; ENSCSAG00000010403; ENSG00000111653; ENSMLEG00000028668; ENSMNEG00000038607; ENSPANG00000008024; ENSRBIG00000029015","","HATs acetylate histones","",0.671,0.761,0.702,0.662,0.754,0.399381608374694,1,1,0.843314533171753,1,88.5,100.4,92.6,131.9,87.3,99.4,67,87.7,95.7,111.4,99.5,80.8,91.8,115.2,85.4,137,108.6,130.7,86.5,78.6,108.7,98.5,126.9,89.7,53,69.4,75.7,88.1,78.7,63.9,72.6,91.1,67.5,108.4,85.9,103.4,68.5,62.2,86,77.9,100.4,70.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q14103-4","Isoform 4 of Heterogeneous nuclear ribonucleoprotein D0 [OS=Homo sapiens]",51,19,210,2,287,30.7,8.41,467.6,"","","","HNRNPD","","","","",0.672,0.784,0.754,0.705,0.771,1,1,1,1,1,86,100.3,96.6,128,90.3,98.8,86.5,74.9,75.6,101.2,88.2,84.1,161.9,84.5,84.9,112.6,107.7,120.2,79.4,85.1,74.9,86.9,214.4,76.9,206.6,178.9,180.6,241.7,210.7,200.8,386.7,201.7,202.8,268.9,257.3,287.1,189.6,203.2,178.9,207.4,511.9,183.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q6ISB3","grainyhead-like protein 2 homolog [OS=Homo sapiens]",1,1,1,1,625,71.1,6.44,1.84,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","GRHL2","ENSG00000083307","Mesodermal commitment pathway","","",0.673,0.981,0.842,0.765,0.741,0.00306740497196111,1,0.565198449020183,0.0710511788457775,0.0414504174780968,80.7,117.7,101,119.9,91.8,88.9,72.8,80.7,81,117.8,96.6,123.3,108.3,98.5,101.1,120,132.4,118.1,101.8,85.2,91.9,88.3,89,93.1,49.9,55.4,55.5,80.8,66.2,84.5,74.2,67.5,69.3,82.3,90.8,81,69.8,58.4,63,60.6,61,63.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8TDI0","Chromodomain-helicase-DNA-binding protein 5 [OS=Homo sapiens]",10,16,54,1,1954,222.9,6.15,131.98,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD5","ENSG00000116254","","","",0.673,0.832,0.671,0.744,0.903,1,1,1,1,1,83.8,103.5,83.5,124.4,92.6,112.3,85.9,73.3,109,84.4,127.5,106.1,85.6,77.5,91,100.2,127.5,154.6,114.9,94.9,87.7,117.9,46.9,115.1,23.1,19.7,29.3,22.7,34.3,28.6,23,20.9,24.5,27,34.3,41.6,30.9,25.5,23.6,31.7,12.6,31,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P57081-1","tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 [OS=Homo sapiens]",10,2,2,2,412,45.5,7.11,3.57,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","","WDR4","ENSG00000160193","","tRNA modification in the nucleus and cytosol","",0.674,0.727,0.781,0.79,0.772,0.722417536277668,1,1,1,1,85.2,92,98.8,126.5,100,97.6,81.8,95.5,82,109,88.4,71.2,95,125.6,87,124.4,111.4,121.6,109.5,96.1,85.9,93.9,129.5,92.2,15.3,17.8,15.3,20.3,16.5,13.3,17.7,23.4,16.2,23.2,20.8,22.7,20.4,17.9,16,17.5,24.2,17.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P34931","Heat shock 70 kDa protein 1-like [OS=Homo sapiens]",31,19,148,1,641,70.3,6.02,303.27,"stress response;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","HSPA1L","ENSG00000204390; ENSG00000206383; ENSG00000234258; ENSG00000236251","Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Attenuation phase","Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Endocytosis; Longevity regulating pathway; Antigen processing and presentation; Estrogen signaling pathway; Prion disease; Legionellosis; Toxoplasmosis; Measles; Lipid and atherosclerosis",0.674,0.878,0.976,0.76,0.741,0.715092611923093,1,1,1,0.724044530099022,80.5,104.7,116.4,119.3,90.7,88.4,80.8,77.6,88.5,105.2,120.8,98,117,111.3,125.8,102.5,121.5,119.9,105.7,74.9,91.1,88.8,110.1,60.6,11.4,10.9,12.4,14.8,17,13.8,16.5,15.7,17.7,14.4,17.1,16.9,14.9,10.5,12.8,12.5,15.5,8.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96EY5-1","Multivesicular body subunit 12A [OS=Homo sapiens]",6,1,2,1,273,28.8,8.91,3.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","LOC93343; MVB12A","ENSG00000141971","7q11.23 copy number variation syndrome","Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; HCMV Late Events","Endocytosis",0.675,0.852,0.851,0.818,0.908,0.086042636821029,1,1,0.341043934489485,1,79.4,100.1,100.1,117.6,96.1,106.7,81.1,70.9,86.3,102.3,109.6,79.3,92.6,102.2,104.6,120.1,134.3,119.9,68.9,98.2,103.4,109.1,107.6,109.6,23.2,20.2,24.7,29.2,31.3,22.6,26.4,29.2,29.9,34.3,38.4,34.3,19.7,28.1,29.5,31.2,30.7,31.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P05155","Plasma protease C1 inhibitor [OS=Homo sapiens]",2,1,1,1,500,55.1,6.55,2.66,"stress response;other biological processes","non-structural extracellular;ER/Golgi;other cell component","enzyme regulator activity","SERPING1","ENSG00000149131","Complement system; RAS and bradykinin pathways in COVID-19; Kinin-Kallikrein pathway; Complement system in neuronal development and plasticity; Complement and coagulation cascades","Regulation of Complement cascade; Platelet degranulation ; Intrinsic Pathway of Fibrin Clot Formation; Defective SERPING1 causes hereditary angioedema","Complement and coagulation cascades; Pertussis",0.675,0.671,0.609,0.771,0.748,1,1,1,1,0.912297264670912,90.6,90,81.6,134.1,103.4,100.3,78.4,146.2,89.4,71.2,88.8,115.3,76.4,80.6,108.9,104.9,150.6,132.4,106.2,102.1,86.9,104.7,58.1,99,43.5,81.1,49.6,39.5,49.2,63.9,42.3,44.7,60.4,58.2,83.5,73.4,58.9,56.6,48.2,58.1,32.2,54.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9HCJ3","Ribonucleoprotein PTB-binding 2 [OS=Homo sapiens]",3,2,3,2,691,74.3,7.47,2.09,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RAVER2","ENSG00000162437","","","",0.675,0.668,0.72,0.648,0.512,1,1,1,1,0.129715531687448,96,94.8,102.3,142.1,92.1,72.7,91.1,113.4,95.4,94.3,97.9,88.4,101.7,96.7,124.7,92.7,142.4,141.3,91.6,109.4,91.3,72.3,64.6,90.9,128.5,160.1,134.6,133.1,138.2,124.7,143.5,136.4,176,130.8,201,199.4,129.2,154.4,128.9,102.1,91.2,128.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P11166","Solute carrier family 2, facilitated glucose transporter member 1 [OS=Homo sapiens]",12,8,46,8,492,54,8.72,91.95,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC2A1","ENSG00000117394","Cori cycle; HIF1A and PPARG regulation of glycolysis; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Insulin signaling; Proximal tubule transport; p53 transcriptional gene network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Neuroinflammation and glutamatergic signaling; Malignant pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Glycolysis and gluconeogenesis","Cellular hexose transport; Regulation of insulin secretion; Vitamin C (ascorbate) metabolism; Lactose synthesis; Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)","HIF-1 signaling pathway; Insulin secretion; Thyroid hormone signaling pathway; Adipocytokine signaling pathway; Glucagon signaling pathway; Insulin resistance; Bile secretion; Human T-cell leukemia virus 1 infection; Pathways in cancer; Renal cell carcinoma; Central carbon metabolism in cancer; Diabetic cardiomyopathy",0.675,0.872,0.815,0.817,0.784,0.00590531009267427,1,0.546266721199767,0.354146242481962,0.194401698503141,81.7,105.4,98.5,120.9,98.7,94.8,77.6,81.2,81.3,106.7,104.8,101.8,95.2,107.3,98,120.6,118.8,120.3,97.3,98.2,100,82.1,114.4,94.3,1484.4,1554.3,1556.2,2041.1,2005.8,1947.1,1821.9,2052.9,1875.2,2306.8,2272.3,2301.1,1862,1878.9,1913,1570.8,2188.5,1803.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q14542","Equilibrative nucleoside transporter 2 [OS=Homo sapiens]",6,2,3,2,456,50.1,6.11,7.8,"transport","plasma membrane;other membranes;nucleus;other cell component","transporter activity","SLC29A2","ENSG00000174669","","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane","Alcoholism",0.676,0.692,0.669,0.726,0.745,0.839420910038886,1,0.728559843218819,0.553000540425534,0.891221346747102,90,92.1,89.1,133.1,96.7,99.1,79.1,119.4,89.9,110.8,92,76.9,97.4,89,87.1,122,133,134.4,69.2,107,96.6,84.8,112.3,99.1,33.1,49.9,37.6,46.3,38.5,32.1,40.7,37.2,36.4,51,55.6,56.2,28.9,44.7,40.4,35.4,46.9,41.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q6P5Z2","Serine/threonine-protein kinase N3 [OS=Homo sapiens]",4,2,2,2,889,99.4,8.46,2.5,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PKN3","ENSG00000160447","PI3K-Akt signaling pathway","RHO GTPases activate PKNs; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle","PI3K-Akt signaling pathway",0.678,0.701,0.599,0.671,0.64,0.054622809147546,0.116587986391621,0.0159689696440119,0.0679508870541902,0.0267238463346809,94.8,98.1,83.8,139.9,93.9,89.5,95.1,87.6,100.7,87.8,98.5,99.9,69.1,103.5,84.1,140.4,134.9,141.8,105.2,94.2,88.1,91.8,87.3,89.8,42.1,38.8,44.6,38.9,43.6,44.3,30.6,45.8,37.3,62.2,59.8,62.8,46.6,41.7,39,40.7,38.7,39.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","Q70EL1-9","Isoform 6 of Inactive ubiquitin carboxyl-terminal hydrolase 54 [OS=Homo sapiens]",1,1,1,1,725,79.7,7.14,0,"","","","USP54","","","","",0.679,0.753,1.089,0.969,0.873,1,1,1,1,1,75.9,84.3,121.8,111.9,108.4,97.7,62.7,76.1,102.6,111.9,81.9,84.5,122.1,156.4,87.7,146.7,101.9,112.2,62.8,108.7,122.7,61.8,99.3,98,9.1,11.1,14.9,16.3,11.9,12.3,17.8,22.8,12.8,21.4,14.8,16.3,9.1,15.8,17.9,9,14.5,14.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96EF0-1","myotubularin-related protein 8 [OS=Homo sapiens]",7,4,5,4,704,78.9,6.65,6.73,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","MTMR8","ENSG00000102043","","Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",0.679,0.78,0.743,0.813,0.823,0.00473211703367042,0.175220789104655,0.0649955208764325,0.170821624105959,0.38190801300136,84.2,96.7,92.2,124,100.8,102,87.7,82.1,82.1,103.2,93.2,94.4,88.7,103.3,89.9,131.8,114.6,121,98.3,94,104.9,99.5,114,97.3,171.3,160.3,160.4,201.6,181.9,184.3,173.3,201.7,175.6,257.5,223.8,236.3,192,183.5,204.9,194.4,222.6,189.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H2E6","Semaphorin-6A [OS=Homo sapiens]",12,9,15,9,1030,114.3,8.41,21.3,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","SEMA6A","ENSG00000092421","Spinal cord injury","Other semaphorin interactions","Axon guidance",0.68,0.722,0.697,0.694,0.695,0.000142733710995991,1.49983387979783E-3,0.000639113348418474,0.000342235633902394,0.000264292237652998,91,96.5,93.2,133.7,92.8,92.8,82.8,91.6,94.8,97.1,100.5,91.2,95.8,91.9,93.8,133.8,136.6,134.5,86.6,93.4,98.5,89.4,94,93.5,340.9,376.8,390.3,399.7,413.5,375.2,394.4,378.4,386.2,550.8,562,553.7,356.2,384.4,405.4,368,386.9,384.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8IZC7","Zinc finger protein 101 [OS=Homo sapiens]",4,2,4,1,436,50.3,9.57,8.6,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF101","ENSG00000181896","","Generic Transcription Pathway","Herpes simplex virus 1 infection",0.681,0.932,0.86,0.758,0.752,0.205654710023838,1,1,0.496254157191346,0.361374591272836,82,112.2,103.6,120.4,91.3,90.6,80.8,103.9,80,117,98.6,110.6,94,102.2,103.9,109.1,118.8,126,90,89.7,99.6,89.3,81.2,105.5,43.3,55.7,42.9,62.7,52.8,59.3,50.4,54.8,55.7,58.5,63.7,67.5,48.2,48.1,53.4,47.9,43.5,56.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","Q9UL41-1","Paraneoplastic antigen Ma3 [OS=Homo sapiens]",2,1,1,1,463,52.4,9.5,0,"","","","","","","","",0.682,0.719,0.695,0.655,0.709,1,1,1,0.854839739929764,1,91.7,96.8,93.4,134.5,88.1,95.4,91.8,80.9,105.2,96.9,99.4,80.2,93.5,121.4,89.1,137.2,97.8,134.7,88.2,63.4,98.2,79.6,147,95.5,21.7,19.1,24.9,22.9,23.5,19,22.1,28.7,21.1,32.5,23.2,31.9,20.9,15,23.2,18.8,34.8,22.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9C0C4","Semaphorin-4C [OS=Homo sapiens]",7,5,8,5,833,92.6,7.28,18.44,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","SEMA4C","ENSG00000168758","","","Axon guidance",0.682,0.744,0.737,0.623,0.643,0.00525822932427703,0.0404727807059994,0.00942962543348707,0.000724303548732683,0.00155076677098156,92.4,100.8,99.8,135.5,84.5,87.1,91.1,105.2,89.4,99.4,96.9,106.6,98.5,88,101.7,138,133.7,132.3,79.5,90.6,83.3,85.9,94.4,85.6,254.6,294,249.7,277.8,270.9,297.8,275.3,246,284.1,385.6,373.5,369.7,222.3,253.1,232.9,240.2,263.8,239.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","O43323","desert hedgehog protein [OS=Homo sapiens]",2,1,1,1,396,43.6,9.28,0,"cell-cell signaling;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","DHH","ENSG00000139549","Hedgehog signaling pathway; Hedgehog signaling pathway; Somatic sex determination; Mammalian disorder of sexual development","Release of Hh-Np from the secreting cell; Activation of SMO; Class B/2 (Secretin family receptors); Ligand-receptor interactions; HHAT G278V doesn't palmitoylate Hh-Np; Transcriptional regulation of testis differentiation","Hedgehog signaling pathway",0.682,0.727,0.786,0.647,0.846,0.13723158596154,0.375755156907224,1,0.0570916375452767,1,87.3,93,100.6,128,82.8,108.3,103.1,85.3,71.3,90.9,94.8,84,122.4,98.2,93.3,159.4,113.9,125,80.8,70.8,86.4,105.8,114.8,99.9,33.3,27.5,23,29.3,30.6,27.1,39.5,31.7,30.1,51.5,36.8,40.4,26.1,22.9,27.9,34.2,37.1,32.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P11169","Solute carrier family 2, facilitated glucose transporter member 3 [OS=Homo sapiens]",15,9,109,9,496,53.9,7.2,232.42,"other metabolic processes;transport","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC2A3","ENSG00000059804","Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K/AKT/mTOR - VitD3 signaling; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis","Neutrophil degranulation; Cellular hexose transport; Vitamin C (ascorbate) metabolism; MECP2 regulates neuronal receptors and channels","",0.683,0.828,0.787,0.81,0.853,4.80854936940976e-05,0.0175242463271036,0.00168829537458659,0.00467286358028795,0.00978191396824231,82.6,100.2,95.2,120.9,98,103.1,82.8,82.1,85.4,98.7,102.4,100.4,92.8,95.4,95.5,126.3,118,121.2,98.2,103.9,93.9,94.3,103.3,105.2,2968.2,2944.2,3062.3,3539.5,3671.8,3599,3326.7,3421.2,3423.3,4528.9,4231.2,4345.4,3521.5,3725.2,3367.8,3381.9,3704.7,3770.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H1J1-1","Regulator of nonsense transcripts 3A [OS=Homo sapiens]",2,1,1,1,476,54.7,9.03,2.97,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UPF3A","ENSG00000169062","","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Nucleocytoplasmic transport; mRNA surveillance pathway",0.684,0.768,0.801,0.736,0.839,0.268677087389027,1,1,0.237381750984276,1,85,95.4,99.6,124.3,91.4,104.3,98.9,85.6,81.9,107.8,93.3,96.2,113.5,92.8,100.3,137.1,125.3,98.9,92.2,77.6,93.1,94.8,105.1,105.8,52.9,45.9,43.8,57.7,49.9,51.5,60.8,49.7,53.7,73.4,67.1,53,49.3,41.5,49.8,50.8,56.3,56.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q08345-1","Epithelial discoidin domain-containing receptor 1 [OS=Homo sapiens]",1,1,1,1,913,101.1,6.83,3.57,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","DDR1","ENSG00000137332; ENSG00000204580; ENSG00000215522; ENSG00000230456; ENSG00000234078; ENSPPAG00000026163; ENSPTRG00000017942","Interactions between LOXL4 and oxidative stress pathway","Non-integrin membrane-ECM interactions","",0.684,0.755,0.855,0.697,0.826,1,1,1,0.956715428836872,1,85.2,94,106.5,124.6,86.8,102.9,83.7,77.8,101.1,92.4,90.3,103.2,104.7,109.6,60.4,152.8,100.8,122.4,85.3,69.9,99.3,97.9,147.4,101.1,54.4,50.6,65.7,60.1,58.7,67.1,68,71.2,39.2,99.3,65.5,79.6,55.4,45.4,64.5,63.6,95.8,65.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O00458","Interferon-related developmental regulator 1 [OS=Homo sapiens]",11,3,3,3,451,50.2,7.18,9.27,"other biological processes","nucleus","","IFRD1","ENSG00000006652","Hypertrophy model","","",0.685,0.774,0.685,0.616,0.705,0.604240301381638,1,0.733732964261908,0.636150411216276,0.867371202818521,92,104,92.1,134.4,82.8,94.7,80,87.8,92.9,113,97.5,99.2,120.1,62.7,87.9,151.7,124.1,128.2,79,119.4,69.6,90.4,112.7,83.6,20.8,22.8,24.1,29.4,25.3,25.8,31.2,16.3,22.8,39.4,32.3,33.3,20.5,31,18.1,23.5,29.3,21.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96JP5-1","E3 ubiquitin-protein ligase ZFP91 [OS=Homo sapiens]",13,5,6,5,570,63.4,7.36,12.7,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","other molecular function","ZFP91","ENSG00000186660","","","",0.685,1.044,1.01,0.967,0.981,0.124077688098563,1,1,1,1,72.3,110.2,106.5,105.5,102,103.5,61.6,70.2,74.9,102.8,111.1,107,120.3,103.4,91.4,98.6,109.9,102.4,99,97.8,106.2,95.7,147.5,100.4,135.7,154.7,165.1,226.6,244.9,235.8,265.1,227.9,201.6,217.4,242.3,225.8,218.3,215.5,234.1,210.9,325.1,221.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O43278","Kunitz-type protease inhibitor 1 [OS=Homo sapiens]",4,2,2,2,529,58.4,6.29,5.43,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","enzyme regulator activity","SPINT1","ENSG00000166145","","MET Receptor Activation; Signaling by MST1","Transcriptional misregulation in cancer; Prostate cancer",0.687,0.815,0.791,0.844,0.798,0.0535048084667046,1,0.366251711828445,0.440947103570655,0.514337302208845,83.5,99.1,96.1,121.6,102.6,97,85.7,91.9,78.4,101.7,104.9,101.1,99.7,85.5,98.6,124.7,112,126.4,81.4,105.2,105.9,90.1,107.2,99.5,82.9,88.9,75.8,98.3,101.4,97.7,96.4,82.7,95.4,120.6,108.3,122.3,78.7,101.7,102.4,87.1,103.6,96.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O43482","Protein Mis18-beta [OS=Homo sapiens]",10,2,2,2,229,24.7,7.37,2.03,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","other molecular function","OIP5","ENSG00000104147","","Deposition of new CENPA-containing nucleosomes at the centromere","",0.687,0.778,0.777,0.669,0.734,0.0514388611464931,0.855970771325814,0.885225287531871,0.0872676019282145,0.166004735735641,88.8,100.5,100.3,129.2,86.4,94.8,89.2,76.6,95.5,94.3,101,108.5,108.5,100.8,100.3,130,114.3,129.8,84,97.8,86.9,106.5,80.6,95.3,68.8,59,73.6,72.7,77.8,83.6,83.7,77.7,77.3,100.2,88.1,100.1,64.8,75.4,67,82.1,62.2,73.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q10589","bone marrow stromal antigen 2 [OS=Homo sapiens]",22,4,16,4,180,19.8,5.6,37.57,"stress response;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","BST2","ENSG00000130303","Ebola virus infection in host; Host-pathogen interaction of human coronaviruses - MAPK signaling","Neutrophil degranulation; Interferon alpha/beta signaling","Herpes simplex virus 1 infection; Human immunodeficiency virus 1 infection",0.688,0.637,0.691,0.706,0.712,0.000309190236166593,3.72350543209143E-4,0.000640624679299364,1.36034020647768E-3,0.00045693692694336,93.1,86.2,93.5,135.3,95.5,96.3,87.5,93.5,94.5,93.3,86.7,85.4,87.7,96.2,93.9,139,136,133.4,96,100.2,95.9,84.7,96.8,99.2,537.4,574.6,580.8,573.4,532.4,524.9,538.5,590.7,577.1,853.7,835.5,819.3,589.8,615.8,589.3,520.5,594.6,609.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P22223-1","Cadherin-3 [OS=Homo sapiens]",10,6,8,4,829,91.4,4.75,13.26,"cell adhesion;cell-cell signaling;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CDH3","ENSG00000062038","Overview of nanoparticle effects; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Malignant pleural mesothelioma","Adherens junctions interactions","Cell adhesion molecules",0.688,0.815,0.724,0.688,0.667,0.0423830407152288,0.899694372759006,0.100951180887063,0.0759889949650507,0.0288499880788643,90.1,106.7,94.8,131,90.1,87.3,84.2,89.7,90.9,106.3,108.6,105.1,96.5,84.7,94.5,143.3,128.9,130.4,88.9,96.8,89.7,87,67.8,106.6,215.5,229.6,232.7,271.9,278,269,247,216.7,241.7,366.7,329.8,333.8,227.4,247.8,229.5,222.6,173.4,272.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P51511","Matrix metalloproteinase-15 [OS=Homo sapiens]",7,3,4,3,669,75.8,7.46,11.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes","enzyme regulator activity;other molecular function","MMP15","ENSG00000102996","Matrix metalloproteinases; Epithelial to mesenchymal transition in colorectal cancer","Collagen degradation; Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action",0.688,0.791,0.787,0.775,0.899,0.131770125050435,0.491043274474064,0.550295682441669,0.437547688664509,0.68748163461487,83.6,96.1,95.5,121.4,94.2,109.2,104.5,83.2,83.2,90.4,95.6,97.3,94.3,101.5,95,118.6,121.5,120.8,93.7,90,106.5,109.6,85.7,108.6,190.4,151.6,151.6,164.8,174.3,177.4,172,185.1,173.2,216.2,221.6,220.2,170.8,164,194.1,199.8,156.3,198,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96BF6","Nucleus accumbens-associated protein 2 [OS=Homo sapiens]",6,3,5,2,587,62.8,5.9,12.07,"cell organization and biogenesis;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","NACC2","ENSG00000148411","","","",0.689,0.872,0.76,0.899,0.774,0.0412894263942232,1,0.334702693674669,1,0.811467967146757,82.8,104.8,91.3,120.1,108,93,84.7,73.6,85.1,107.7,107.3,99.7,94.3,93.4,85.1,125.9,105.3,123,110.6,88.1,117.3,95.2,109.1,94.5,154.7,134.4,155.5,196.7,195.9,182.1,172.3,170.6,155.4,230,192.2,224.6,201.9,161,214.2,173.8,199.2,172.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P54646","5'-AMP-activated protein kinase catalytic subunit alpha-2 [OS=Homo sapiens]",14,6,10,3,552,62.3,7.75,19.5,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PRKAA2","ENSG00000162409","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; PI3K/AKT/mTOR - VitD3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Head and neck squamous cell carcinoma; Insulin signaling; 1q21.1 copy number variation syndrome; Autophagy; Malignant pleural mesothelioma","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Carnitine metabolism; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","FoxO signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy; Fluid shear stress and atherosclerosis",0.689,0.827,0.803,0.714,0.735,0.00622969447482941,0.238616328876112,0.154455482549515,0.0106216312524811,0.069286139166905,86.7,104.1,101,125.8,89.9,92.5,94.7,82.1,85.8,103,96.2,103,98.3,101.1,100,131.3,118.2,124.5,88.9,86.8,92.2,91.6,112.3,90,189.1,163.9,171.4,205.7,192,205.6,196.1,201.7,199.6,262.1,236,248.6,177.5,173.3,184.1,182.8,224.1,179.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q9ULN7-5","Isoform 2 of Paraneoplastic antigen-like protein 8B [OS=Homo sapiens]",2,1,1,1,635,68.6,5.45,1.9,"","","","PNMA8B","ENSG00000204851","","","",0.69,0.809,0.828,0.737,0.812,0.293344702637792,1,0.989029108380202,0.45239924775378,0.98641540611199,84.9,99.5,101.9,123.1,90.7,99.9,68.4,92.6,85.7,102.1,100.4,99.7,106.3,102.8,76.1,157.7,118.5,124.2,100,69.2,91.6,100.8,127.8,75.9,20.9,28.4,26.2,31.2,30.7,30.5,32.6,31.5,23.3,48.3,36.3,38,30.6,21.2,28,30.9,39.1,23.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y6K1-2","Isoform 2 of DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",49,28,94,1,723,81.6,6.81,160.75,"","","","DNMT3A","","","","",0.69,0.775,0.777,0.63,0.766,0.366606567694884,1,0.995744787747919,0.375713132856109,0.645928102759874,89.3,100.2,100.5,129.4,81.5,99.1,77.1,86.3,106.1,96.9,113.4,91.6,105.7,97.1,89.5,119.1,133,125,76.8,78.8,116.7,100.4,95.8,90.7,26.5,29.6,36.4,33.2,38.9,31.4,36.3,33.3,30.7,40.9,45.7,42.9,26.4,27,40,34.5,32.9,31.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96PU8-3","Isoform 2 of Protein quaking [OS=Homo sapiens]",29,8,22,7,333,36.9,8.56,49.91,"","","","QKI","","","","",0.693,0.797,0.754,0.658,0.689,2.67447474268236e-05,0.00137145668159252,0.000221614563200003,8.76110193141559e-06,1.66857947775503e-05,90.5,104.2,98.6,130.7,85.9,90.1,96.1,89.5,88.1,102,103,103.4,97.3,97.5,98.5,137.1,129.2,129.1,84.9,83.9,92.8,90.6,89.1,88,916,852.9,839.7,972.1,981.7,985.4,927,928.9,939.3,1306.9,1231.3,1230.3,809.6,800.1,884.5,863.8,848.9,838.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8TD17","Zinc finger protein 398 [OS=Homo sapiens]",4,2,2,2,642,71.3,6.67,5.8,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF398","ENSG00000197024","","Generic Transcription Pathway","Herpes simplex virus 1 infection",0.693,0.678,0.699,0.779,0.732,0.058731591396739,0.050115466603441,0.130052042114106,0.515587075010293,0.116091345875777,90.7,88.8,91.5,131,102.1,95.9,91.4,101.5,79.9,74.3,95.3,89.5,92.2,91,96.8,131.9,140.6,118.5,102.8,109.7,99.8,96.6,84,104.1,112.7,125.1,98.5,91.7,117.6,110.4,113.7,112.3,119.4,162.7,173.5,146.1,126.8,135.3,123.1,119.1,103.6,128.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O14757","Serine/threonine-protein kinase Chk1 [OS=Homo sapiens]",22,9,14,9,476,54.4,8.25,28.33,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CHEK1","ENSG00000149554","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; DNA damage response","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis",0.694,0.685,0.686,0.717,0.607,0.0362159922197837,0.0342241910978627,0.0334695718456047,0.0377019052415196,0.00228524332119206,94.9,93.6,93.7,136.7,98.1,83,91.9,105.8,94.1,91.8,95,92.8,90.7,93,102.1,121.1,145.6,135.6,97.3,100.4,93.5,82.3,73.1,94,600.3,691,614.3,599.5,620.3,606.2,592.6,607.1,666.7,791,950.8,885.6,635.4,656,610.3,537.2,477.3,613.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q5U4P2","Aspartate beta-hydroxylase domain-containing protein 1 [OS=Homo sapiens]",3,1,1,1,390,41.1,8.56,2.56,"protein metabolism;other metabolic processes","other membranes","other molecular function","ASPHD1","ENSG00000174939","16p11.2 proximal deletion syndrome","","",0.694,0.717,0.724,0.779,0.78,0.151864569384789,0.308826676362161,0.658662138844637,0.797727593391551,0.840897137959409,88.7,91.6,92.5,127.8,99.6,99.7,88.6,99.8,74.4,77.1,91.5,97.7,92.4,105.8,91.7,127.7,139.1,109.2,99.5,99.5,98.8,99.6,90,117.6,44.3,49.9,37.2,38.5,45.7,48.9,46.2,52.9,45.9,63.8,69.5,54.6,49.8,49.7,49.4,49.8,45,58.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P57087-1","Junctional adhesion molecule B [OS=Homo sapiens]",10,2,3,2,298,33.2,9.09,8.45,"cell adhesion;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","JAM2","ENSCANG00000028858; ENSG00000154721; ENSMFAG00000042681; ENSMLEG00000034543; ENSMMUG00000008723; ENSMNEG00000037546; ENSPANG00000016226; ENSPPAG00000034525; ENSPPYG00000011304; ENSPTRG00000013808","","Integrin cell surface interactions; Cell surface interactions at the vascular wall","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Epithelial cell signaling in Helicobacter pylori infection",0.694,0.674,0.66,0.681,0.726,0.00389922132698533,0.00557626261969003,0.00230863272776199,0.00153303280964765,0.00518557665331945,93.9,91.2,89.3,135.3,92.1,98.2,94,86,105.2,88.4,91.3,98.1,89.4,89.1,91.1,135.4,145.4,130.3,92.2,93.6,83,98.2,89.2,100.3,88,80.5,98.5,82.8,85.5,91.9,83.7,83.5,85.3,126.8,136.2,122.1,86.4,87.6,77.7,92,83.6,94,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","P25942-1","Tumor necrosis factor receptor superfamily member 5 [OS=Homo sapiens]",3,1,1,1,277,30.6,5.76,0,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","other molecular function","CD40","ENSG00000101017","Allograft rejection; Complement system; Vitamin D receptor pathway; Nod-like receptor (NLR) signaling pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Inflammatory response pathway; Genes associated with the development of rheumatoid arthritis; Toll-like receptor signaling pathway","","Cytokine-cytokine receptor interaction; NF-kappa B signaling pathway; Cell adhesion molecules; Toll-like receptor signaling pathway; Intestinal immune network for IgA production; Malaria; Toxoplasmosis; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Transcriptional misregulation in cancer; Asthma; Autoimmune thyroid disease; Systemic lupus erythematosus; Allograft rejection; Primary immunodeficiency; Viral myocarditis; Lipid and atherosclerosis",0.695,0.787,0.726,0.693,0.801,0.249994960017067,0.980710397490191,0.288103250775981,0.106557737513766,0.392836967309407,88.7,100.4,92.7,127.6,88.4,102.2,88.3,88.8,103.4,111.4,91.3,100.5,92.8,102,83.5,127.8,140.8,113.3,75.3,100.2,88.5,103,102.3,86.7,50.2,50.5,58.8,63.3,51.9,57.2,52.8,58,47.5,72.7,80.1,64.4,42.8,57,50.3,58.6,58.2,49.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UIU6","Homeobox protein SIX4 [OS=Homo sapiens]",14,7,12,6,781,82.9,5.71,13.8,"cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SIX4","ENSG00000100625","mir-124 predicted interactions with cell cycle and differentiation","","Transcriptional misregulation in cancer",0.695,0.85,0.767,1.037,0.99,0.628205100901138,1,1,1,1,78.1,95.5,86.2,112.4,116.5,111.3,77.8,76,80.8,112.4,95.2,85.1,83,91.8,85.8,142.8,112,89.4,74.2,116.1,117.4,110.9,108.6,140.7,260.5,254.3,270.5,376.1,318.6,285,277.6,307.3,287.3,477.9,374.8,299.2,248.3,388.6,393,371.1,363.5,470.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q68CL5-1","Isoform 1 of Tubulin polyglutamylase complex subunit 2 [OS=Homo sapiens]",4,1,1,1,257,28.6,8.12,1.86,"","","","TPGS2","","","","",0.696,0.755,0.669,0.706,0.634,0.0497646644061702,0.235968794982656,0.0162719161727891,0.0738717249082108,0.00308244102621448,93.6,101.6,90,134.5,95,85.2,94.2,99.8,93.4,102.2,102.9,100.4,81,90.8,90.6,135.4,138.4,134.4,92.8,105.8,95.6,92.4,64.2,85.8,82.1,86.9,81.4,89.1,89.7,87.5,70.6,79.1,79,118,120.6,117.2,80.9,92.2,83.3,80.6,56,74.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q7L190","Developmental pluripotency-associated protein 4 [OS=Homo sapiens]",54,15,66,15,304,33.5,9.52,153.1,"developmental processes","nucleus","other molecular function","DPPA4","ENSG00000121570","","POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","",0.696,0.769,0.742,0.703,0.682,4.39470228566007e-06,8.6387763158389e-05,1.19968237763233e-05,3.03362092952468e-06,1.41166382006836E-6,90.9,100.5,96.9,130.7,91.9,89.1,88.1,91,96.5,103.2,100.6,100,97,94.6,97.1,131.4,130.8,129,92,92,91.3,85.7,89.2,90.5,3171.7,3275.3,3472.2,3713.8,3618.6,3597.4,3491.7,3404.8,3493.2,4729.3,4706.9,4642.2,3308.7,3310.9,3284.7,3084.1,3208.3,3254.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q9P283","Semaphorin-5B [OS=Homo sapiens]",1,1,1,1,1151,125.8,7.65,0,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","other membranes","signal transduction activity or receptor binding","SEMA5B","ENSG00000082684","","Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins","Axon guidance",0.696,0.778,0.971,0.635,0.716,0.711234389316119,1,1,0.152223132290709,0.533760310520744,87.1,97.3,121.4,125.1,79.5,89.6,85,71.9,118.7,84.8,94.9,125.9,119.9,118.5,106,147.7,122.1,114.9,77.6,60.4,87.7,93,87.4,83.5,24.3,20.5,33.9,24.2,27.1,36,34.2,33.8,30.3,42.2,34.9,32.8,22.2,17.3,25.1,26.6,25,23.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NS93","Transmembrane 7 superfamily member 3 [OS=Homo sapiens]",5,2,2,2,570,64.1,7.01,2.04,"stress response;other biological processes","plasma membrane;other membranes","","TM7SF3","ENSG00000064115","","","",0.698,0.709,0.68,0.746,0.748,0.00408174697838778,0.00612257663082052,0.00216817995869471,0.0100205869668146,0.0138419548543101,91.4,92.8,89.1,131,97.7,98,89.9,85.6,105.2,91.3,92.4,90.2,87.6,94,83.1,139.4,127.3,128.8,98.7,96.1,95.4,93.6,105,96.4,86,81.8,100.6,87.3,88.3,86.3,83.8,89.9,79.4,133.3,121.8,123.2,94.3,91.9,91.3,89.5,100.4,92.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","Q8NEV8-1","Exophilin-5 [OS=Homo sapiens]",1,1,2,1,1989,222.4,7.87,0,"transport;developmental processes;other biological processes","other cytoplasmic organelle","other molecular function","EXPH5","ENSG00000110723","Deregulation of Rab and Rab effector genes in bladder cancer","","",0.699,0.771,0.959,0.82,0.912,0.651766562117481,1,1,1,1,81.3,89.7,111.5,116.3,95.3,106,76.5,107.8,80.5,88.8,91.4,88.2,110.4,102.8,117.8,96.4,117.2,115.1,93.1,109.4,94.4,105,95,110.3,63,88.8,66.3,73.1,75.3,72.6,90.9,84.7,97.1,79.4,96.6,94.8,76.7,90.1,77.7,86.5,78.3,90.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O00507-1","Probable ubiquitin carboxyl-terminal hydrolase FAF-Y [OS=Homo sapiens]",14,31,68,5,2555,290.9,5.86,132.56,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","USP9Y","ENSG00000114374","","","",0.699,0.839,0.874,0.783,0.746,0.260395666115314,1,1,0.330513339978126,0.300245721797856,84.9,101.9,106.1,121.4,95.1,90.6,99,82.4,86.8,104.1,93.3,104.5,91.1,108.4,110.9,120.1,127.5,124.1,75.6,100.9,97.2,106.7,92.6,75.1,64.9,54,56.9,68.3,61.1,68.5,59.7,71,72.7,78.7,83.5,81.3,49.5,66.1,63.7,69.9,60.7,49.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q15051-1","IQ calmodulin-binding motif-containing protein 1 [OS=Homo sapiens]",7,4,6,4,598,68.9,9.1,4.73,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","IQCB1","ENSG00000173226","Ciliary landscape; Ciliopathies","Anchoring of the basal body to the plasma membrane","",0.7,0.718,0.705,0.714,0.744,0.171154054952855,0.122726840979605,0.107497577799358,0.0586996777899955,0.104700232683253,91.6,94,92.3,131,93.5,97.5,117.4,88,90.1,92.4,95.9,88.7,90.7,98.5,90.8,128.8,125.9,132.4,102.8,80.9,91.9,89,99.8,95.8,234.4,175.6,179.8,184.4,191.4,177,181.1,196.5,181.1,257,251.2,264.3,205.2,161.4,183.5,177.7,199.2,191.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O15151","Protein Mdm4 [OS=Homo sapiens]",5,2,2,2,490,54.8,5,2.63,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","nucleus","other molecular function","MDM4","ENSG00000198625","Glioblastoma signaling pathways; Malignant pleural mesothelioma","Regulation of TP53 Activity through Methylation; Ub-specific processing proteases; Regulation of TP53 Degradation; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Oncogene Induced Senescence; Stabilization of p53","p53 signaling pathway; MicroRNAs in cancer",0.7,0.799,0.753,0.727,0.853,0.601823131082514,1,0.96321740992099,0.59943638734852,1,87,99.2,93.5,124.2,90.3,105.9,100.1,87.8,81.2,117.7,100.2,66.2,94.4,105.6,80.1,126.4,117.7,125.4,84.1,91.2,92,107,106.7,116.2,44.2,38.8,35.9,51.9,44.2,29.2,41.7,46.6,35.4,55.8,52,55.4,37.1,40.2,40.6,47.2,47.1,51.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","P20062-1","Transcobalamin-2 [OS=Homo sapiens]",2,1,1,1,427,47.5,7.01,0,"transport","non-structural extracellular;other cytoplasmic organelle","other molecular function","TCN2","ENSG00000185339","Vitamin B12 metabolism; One-carbon metabolism; Male infertility","Cobalamin (Cbl, vitamin B12) transport and metabolism; Defective TCN2 causes TCN2 deficiency; Defective CD320 causes MMATC","Vitamin digestion and absorption",0.701,0.694,0.751,0.78,0.643,0.228036700049977,0.195605035461542,0.456226381528124,0.272127909021536,0.123961995202507,92,91.2,98.6,131.3,102.4,84.5,79.9,112.8,89.9,95.5,79.7,89.1,95.4,96.3,100.8,118,162.5,128.3,100.5,100.1,83.4,81.8,82.6,103.5,59.1,83.4,66.5,70.6,59,65.9,70.5,71.3,74.5,87.3,120.2,94.9,74.3,74,61.7,60.5,61.1,76.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q08380","Galectin-3-binding protein [OS=Homo sapiens]",8,3,3,3,585,65.3,5.27,7.55,"cell adhesion;stress response;transport;signal transduction","non-structural extracellular;other membranes;other cell component","other molecular function","LGALS3BP","ENSG00000108679","Network map of SARS-CoV-2 signaling pathway","Platelet degranulation","",0.702,0.787,0.814,0.795,0.939,0.0179391661547963,0.704493669834864,0.602612978635861,0.396223072089981,1,83.6,93.7,96.9,119.1,94.7,111.9,93.3,69.4,83.9,103.2,94,94,97.2,93.9,101.5,119.5,109.7,122.7,93.6,95,99.5,112.2,101.2,116.2,91.1,67.7,81.9,100.8,91.8,91.8,94.9,91.7,99.2,116.7,107.1,119.8,91.5,92.8,97.1,109.6,98.8,113.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8TDD1-2","Isoform 2 of ATP-dependent RNA helicase DDX54 [OS=Homo sapiens]",33,21,49,1,882,98.6,10.02,132.73,"","","","DDX54","","","","",0.702,0.954,0.891,0.674,0.976,0.751213102892962,1,1,1,1,81.1,110.1,102.8,115.4,77.8,112.7,69.8,77.6,80.5,107.5,90.6,105.4,98.5,116.8,82.9,127.1,97.5,110.5,74.4,73.3,112,107.9,170.8,96.8,35.3,39.3,40.8,54.5,45.9,53.4,49.9,59.2,42,64.4,49.4,56,37.7,37.2,56.8,54.7,86.5,49,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8WXI2-1","Connector enhancer of kinase suppressor of ras 2 [OS=Homo sapiens]",1,1,1,1,1034,117.5,6.79,3.99,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CNKSR2","ENSG00000149970; ENSGGOG00000013768","","Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants","",0.704,0.809,0.692,0.648,0.749,0.970566446133394,1,0.966238215599629,0.743634606991222,1,91.7,105.5,90.2,130.4,84.5,97.7,106.2,78.8,90.3,117.7,76.3,103.8,88.8,104.2,75.9,128.3,102.6,145.7,80.1,83.2,99.2,96.1,129.8,92.8,38.6,28.7,32.9,42.8,27.8,37.8,32.3,37.9,27.6,46.7,37.3,53,29.2,30.3,36.1,35,47.3,33.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q9H992","E3 ubiquitin-protein ligase MARCH7 [OS=Homo sapiens]",1,1,1,1,704,78,6.77,2.04,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","MARCHF7","ENSG00000136536","","","",0.704,0.725,0.79,0.669,0.689,0.199607072556585,0.433875404390802,0.514339258232632,0.0644723809720892,0.129453463961731,92.3,95.1,103.5,131.1,87.7,90.3,101.9,91,92.2,95,87.2,109.7,90.1,106.5,103.5,114.6,131.1,132.3,90,87.7,87.5,90.3,81.5,107.9,83.8,74.8,75.8,78.1,71.7,90.1,74.1,87.5,85.1,94.2,107.7,108.8,74,72.1,71.9,74.2,67,88.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UKA9-1","Polypyrimidine tract-binding protein 2 [OS=Homo sapiens]",27,8,38,1,531,57.5,8.66,69.19,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","LOC101350812; PTBP2","ENSANAG00000033752; ENSCSAG00000001494; ENSG00000117569; ENSMMUG00000016130; ENSPANG00000001229; ENSPPYG00000001132","Genes targeted by miRNAs in adipocytes; mRNA processing","","",0.704,0.759,0.769,0.694,0.712,0.000437872480926655,0.00247897870258712,0.00273039631663109,0.000279965471755708,0.000185276738103977,91.1,98.2,99.5,129.4,89.8,92.1,91.8,96.7,91.3,98.9,100.5,90.4,95,100.5,100.2,126.3,137.9,130.4,90.6,90.3,90.5,92.8,82.6,93.4,414.5,436.6,412.4,446.7,453.8,408.3,428.9,453.9,452.7,570.5,622.8,588.8,409.1,407.7,408.5,419,373,421.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96EY4","translation machinery-associated protein 16 [OS=Homo sapiens]",8,2,3,2,203,23.8,9.26,2.01,"","nucleus","","TMA16","ENSG00000198498","","","",0.704,0.832,0.894,1.004,0.854,0.97814387085096,1,1,1,0.994369818081653,79.9,94.4,101.4,113.5,113.9,96.9,68.4,77.8,78.6,101.6,92,83.8,98.8,98.9,97.4,223.7,110.5,79.5,150.6,110.9,83.2,94.4,54,95.8,86.7,98.6,99.6,128.8,116.6,106.2,125.2,125.4,123.4,283.5,140,100.7,190.8,140.6,105.4,119.6,68.5,121.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","A6NFI3","Zinc finger protein 316 [OS=Homo sapiens]",2,2,4,2,1004,108.4,5.31,7.23,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF316","ENSG00000205903","","","Herpes simplex virus 1 infection",0.705,0.784,0.808,0.737,0.839,0.0208680370065078,0.155988060858011,0.28852615327403,0.0391797589548516,0.871912017125745,86.8,96.6,99.5,123.1,90.7,103.3,85.6,86.9,93.2,96.8,89.9,96.6,103.8,99.6,92.7,125.8,111.5,123.2,87.9,90.8,94.2,103.4,121.8,96.3,262.5,266.3,285.7,296.9,275.5,296.3,318.2,305.3,284.3,385.8,341.7,377.7,269.3,278.3,288.7,317,373.4,295.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96RU2-2","Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 28 [OS=Homo sapiens]",19,14,22,14,1045,119,5.16,49.81,"","","","USP28","","","","",0.705,0.8,0.736,0.696,0.706,4.58184675782737E-3,0.168611447415227,0.0137803598534293,1.95391377609114E-3,0.00665852177874033,91.1,103.4,95.1,129.2,89.9,91.2,91.3,90.1,95.9,97.2,103.6,111.5,92.6,95.3,97.3,131.9,117.4,129.4,90.1,81.2,94.2,98.9,90.7,91.4,665.3,656.8,699.3,708.6,755.2,812.4,675.2,694.7,709.4,961.6,856,943.5,656.5,591.9,686.5,720.6,661.5,666.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","A4D1F6","Leucine-rich repeat and death domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,860,98,7.46,0,"signal transduction;other biological processes","","","LRRD1","ENSG00000240720","","","",0.706,1.06,0.881,1.039,0.784,1,1,1,1,1,77.5,116.3,96.6,109.7,113.9,86,133.5,73.3,77.8,116.7,90,119.2,97,72.9,106.3,110.2,106.2,119.1,142.5,114.4,60.2,86.3,75.9,98.5,21.1,11.6,12.3,18.5,14.2,18.9,15.3,11.5,16.8,17.4,16.8,18.8,22.5,18.1,9.5,13.7,12,15.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9P2B2","prostaglandin F2 receptor negative regulator [OS=Homo sapiens]",18,13,18,13,879,98.5,6.61,36.28,"cell organization and biogenesis;other biological processes","other membranes;ER/Golgi","","PTGFRN","ENSG00000134247","Prostaglandin synthesis and regulation","","",0.707,0.798,0.739,0.701,0.677,4.75791713351225e-07,2.30917216781985E-5,2.61761335720404e-06,2.17665473656899e-07,7.87823156711553e-08,91.8,103.6,96,129.8,90.9,87.9,92.1,88.3,92.4,101.3,104.3,103.9,98.1,96.3,95.6,130.3,132.8,128.1,88.3,91.7,91.3,86.8,88.2,90.1,990.6,949.9,994.1,1090,1121.6,1117.9,1055.4,1036.1,1027.9,1401.4,1428.6,1377.8,949.5,986.5,981.7,933.4,949,968.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q14517","Protocadherin Fat 1 [OS=Homo sapiens]",0,2,2,2,4588,506,5,4.9,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","FAT1","ENSG00000083857","Primary focal segmental glomerulosclerosis (FSGS); Head and neck squamous cell carcinoma","","",0.707,0.731,0.74,0.799,0.8,0.495385328132729,0.521532564897287,1,1,0.874039514167029,88.8,91.8,93,125.6,100.3,100.5,88,94.6,86.7,90.9,93.8,75.3,84.8,92.1,115.6,124.4,112.6,128.9,119.3,98.3,99.4,99.6,78.4,117.3,67.8,72.9,66.8,70.1,72.3,58.1,65.3,71,89.1,95.9,86.8,99.4,92,75.8,76.6,76.7,60.4,90.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P23471-1","Receptor-type tyrosine-protein phosphatase zeta [OS=Homo sapiens]",3,6,12,6,2315,254.4,4.88,22.97,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PTPRZ1","ENSG00000106278","Spinal cord injury; VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway","Other interleukin signaling; Signaling by ALK","Epithelial cell signaling in Helicobacter pylori infection",0.707,0.705,0.71,0.705,0.673,0.000375605580314839,0.00107019857401388,1.63518835429626E-3,7.79818809256351E-4,0.000274661785418518,94.3,94,94.6,133.3,94,89.7,96.4,94.1,86.6,90.5,94.1,93.8,92.1,94.4,102.9,130,135.8,133.1,95.7,93.9,93.8,89.5,84.8,98.3,559.8,546.8,503.1,525.8,546.6,544.9,534.8,548.5,597.5,755.1,789,773.1,555.6,545.2,544.8,520.1,492.8,570.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P30047","GTP cyclohydrolase 1 feedback regulatory protein [OS=Homo sapiens]",19,1,1,1,84,9.7,6.54,2.46,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","GCHFR","ENSG00000137880","","Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","",0.708,1.177,0.989,0.992,0.953,1,1,1,1,1,73,121.4,102,103.1,102.3,98.2,74.3,73.4,113.4,123.6,128.2,115.3,103.7,74.1,105.6,106.6,54.9,104.9,104,96,125.3,103.9,100,92.7,10.8,10.7,16.5,17.9,18.6,16.7,15.1,10.8,15.3,15.5,8,15.2,15.1,13.9,18.2,15.1,14.5,13.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P06239-1","Tyrosine-protein kinase Lck [OS=Homo sapiens]",7,3,8,2,509,58,5.36,25.38,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function","LCK","ENSG00000182866; ENSGGOG00000002562; ENSPPAG00000031166","Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Inflammatory response pathway; Cancer immunotherapy by PD-1 blockade; IL-18 signaling pathway; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; Interferon type I signaling pathways; Notch signaling pathway; T-cell receptor (TCR) signaling pathway","RHOH GTPase cycle; Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; DAP12 signaling; CD28 dependent PI3K/Akt signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Regulation of KIT signaling; CD28 dependent Vav1 pathway; Nef Mediated CD4 Down-regulation; Interleukin-2 signaling; Nef and signal transduction; PECAM1 interactions; CTLA4 inhibitory signaling; FLT3 signaling through SRC family kinases","NF-kappa B signaling pathway; Osteoclast differentiation; Natural killer cell mediated cytotoxicity; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Yersinia infection; Human T-cell leukemia virus 1 infection; PD-L1 expression and PD-1 checkpoint pathway in cancer; Primary immunodeficiency",0.708,0.786,0.785,0.745,0.735,5.95508589977626E-5,0.0026257646018087,1.03315821107237E-3,0.000524586550398252,9.89732086333792e-05,89.3,99.1,99,126.1,93.9,92.6,87.2,90.1,89.4,100.9,99.2,97.7,101.3,92.7,99,126,127,126.2,93.9,93.2,101.9,86.5,94.9,92.7,167.2,172.8,171.4,193.5,190.2,187.4,194.3,177.8,189.9,241.6,243.5,241.9,180.1,178.7,195.4,165.8,182,177.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O75147","Obscurin-like protein 1 [OS=Homo sapiens]",9,12,17,12,1896,206.8,5.63,32.06,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","OBSL1","ENSG00000124006","","Neddylation","",0.709,0.799,0.776,0.781,0.789,0.000639625911209581,0.0285787417659059,0.0400325545866354,0.0117997685340378,0.00980706775117682,87.6,98.7,95.9,123.6,96.5,97.6,85.2,88.1,86.7,96.5,97.7,98.6,112,94,94.9,118.4,122.4,126.6,95.1,99.6,95.5,92.4,99.7,96.5,565.6,584.8,575.5,640.5,648.5,654.6,743.1,623.7,630.1,785.7,812.1,839.9,631.5,661.3,634,613,662,640.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","O43353-1","Receptor-interacting serine/threonine-protein kinase 2 [OS=Homo sapiens]",1,1,1,1,540,61.2,7.09,2.02,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","RIPK2","ENSG00000104312","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor (TCR) signaling pathway","Downstream TCR signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases","NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Shigellosis; Salmonella infection; Tuberculosis",0.709,0.705,0.666,0.758,0.68,0.320914751121072,0.290542526747531,0.249445823644019,0.974788622016793,0.393111891737258,94.1,93.6,88.5,132.8,100.6,90.3,99,88.1,94.4,93.8,103.3,74.3,100.5,88.8,82.3,133.2,133.7,111.2,100.9,108,99.6,90.6,87.7,110.7,36.2,32.2,34.6,34.4,37.8,27.2,36.8,32.5,30.1,48.8,48.9,40.7,36.9,39.5,36.5,33.2,32.1,40.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q53TQ3","INO80 complex subunit D [OS=Homo sapiens]",4,3,3,3,878,98.1,8.18,5.74,"","","","","","","","",0.709,0.78,0.767,0.816,0.763,0.260444806820293,0.972049299228415,0.387999314879316,0.70085057168089,0.320419260618273,88,96.8,95.2,124.1,101.3,94.7,90.2,99.1,86.2,101.7,99.1,94.5,97.5,78.7,104.1,130.8,112.3,127.1,103.8,88,104.8,105.8,79.4,97,62.4,68.6,59.6,70.4,68.6,65.4,67.5,54.5,72,90.5,77.7,88,71.8,60.9,72.5,73.2,54.9,67.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q14451","Growth factor receptor-bound protein 7 [OS=Homo sapiens]",6,3,3,3,532,59.6,8.5,2.72,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","nucleic acid binding activity;other molecular function","GRB7","ENSG00000141738","Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway","RET signaling; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; RND1 GTPase cycle; GRB7 events in ERBB2 signaling","",0.71,0.78,0.612,0.687,0.789,1,1,0.8818100919377,0.665432493534592,1,93,102.3,80.2,131.1,90.1,103.4,89.8,78.5,119.5,91,114,98.7,119.7,74.3,77.4,133.8,126.5,124.5,87.4,87,84.4,121.9,72.1,99.7,71.3,62.3,94.8,72.2,90.5,78.4,95,59,61.5,106.3,100.4,98.8,69.4,69,67,96.7,57.2,79.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P54274-1","telomeric repeat-binding factor 1 [OS=Homo sapiens]",14,4,4,4,439,50.2,6.37,5.83,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","TERF1","ENSG00000147601","","Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand","",0.711,0.713,0.738,0.708,0.736,0.152368912789473,0.167519599483321,0.224048833765686,0.168966757315537,0.0970708496602839,92.6,92.9,96.1,130.3,92.3,95.9,92.8,102.2,89.1,82.8,93,99.8,90,100.2,96.3,113.5,148.2,130.5,86.4,106.8,92.4,99.7,80.3,96,113.1,124.6,108.6,101,113.4,121.7,109.7,122.1,117.4,138.4,180.7,159.1,105.4,130.2,112.7,121.6,97.9,117.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9GZV8","PR domain zinc finger protein 14 [OS=Homo sapiens]",1,1,2,1,571,64,7.08,4.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PRDM14","ENSG00000147596","Endoderm differentiation","Transcriptional regulation of pluripotent stem cells","",0.712,0.803,0.802,0.71,0.679,0.355124164659859,0.7458984073868,0.619339455249693,0.453747209911313,0.12668828555071,90.8,102.4,102.3,127.5,90.5,86.5,108.2,86.9,88.6,89,99.9,101.5,90.8,99.8,101.1,124.4,132.3,123.4,88.3,122.9,81.2,94.2,84.4,82.9,112.6,90.4,92.2,92.6,104,105.7,94.5,103.8,105.2,129.5,137.7,128.4,91.9,127.9,84.5,98,87.9,86.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NP50-1","Protein FAM60A [OS=Homo sapiens]",23,4,9,4,221,24.8,9.41,24.78,"other biological processes","nucleus","","FAM60A; SINHCAF","ENSBIXG00000026587; ENSBIXG00005028216; ENSBMUG00000013194; ENSBTAG00000001161; ENSCAFG00000010685; ENSCANG00000005164; ENSCATG00000044294; ENSCHIG00000014161; ENSCJAG00000001215; ENSFCAG00000039933; ENSG00000139146; ENSG00000276371; ENSGGOG00000015484; ENSLCNG00005016798; ENSMLEG00000029038; ENSMMUG00000009155; ENSMNEG00000042795; ENSNLEG00000016487; ENSOGAG00000008927; ENSPANG00000003570; ENSPCTG00005010938; ENSPPAG00000042070; ENSPPYG00000004396; ENSPTRG00000046729; ENSSSCG00000037732; ENSSSCG00070025131; ENSSSUG00005012647; ENSVVUG00000007293","","","",0.712,0.838,0.805,0.761,0.743,0.0289837973557498,1,0.398762036689825,0.171296928869362,0.288540399849469,87.9,103.5,99.4,123.5,94,91.7,87.1,88.8,85.1,110.6,102.5,97.7,93.8,101.1,98.5,122.3,109.4,124.5,90.5,93.1,100.5,90.1,113.5,90.9,305.7,311.6,298.6,388.2,359.7,342.8,329.3,355,345.7,429.3,383.8,436.8,317.6,326.6,352.8,316.2,398.2,318.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q7Z7B0","Filamin-A-interacting protein 1 [OS=Homo sapiens]",2,2,2,2,1213,138,8.32,0,"","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","","FILIP1","ENSG00000118407","","RHOD GTPase cycle","",0.713,0.782,0.811,0.732,0.653,1,1,1,0.784585745502247,0.211452572951919,91.2,100,103.8,127.9,93.6,83.5,120.2,83.9,92.5,94.1,101.4,110.7,105.2,80.6,110.8,129.7,129.7,119.8,114.6,71,94.9,87.4,68.7,84.7,39.5,27.5,30.4,30.9,33.3,36.4,34.5,26.5,36.4,42.6,42.6,39.3,37.6,23.3,31.2,28.7,22.5,27.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96DN5-1","TBC1 domain family member 31 [OS=Homo sapiens]",2,1,1,1,1066,124.1,8.62,3.45,"","cytoskeleton","","TBC1D31","ENSG00000156787","","","",0.714,0.778,0.744,0.644,0.615,0.870639649360571,1,0.651498819226526,0.315015584023701,0.31658937564989,95.3,103.9,99.3,133.5,86,82.1,107.7,92,93.2,101.9,101.5,98.2,98,80.7,97.1,148,130.5,125.1,99.3,73.7,84,80.3,63.6,125.1,57.5,49.1,49.7,54.4,54.2,52.4,52.3,43.1,51.8,79,69.7,66.8,53,39.3,44.9,42.8,34,66.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","Q9UIX4","Potassium voltage-gated channel subfamily G member 1 [OS=Homo sapiens]",2,1,1,1,513,57.9,6.29,0,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes","transporter activity","KCNG1","ENSG00000026559","","Voltage gated Potassium channels","",0.714,0.992,0.73,1.118,0.99,0.900215621915263,1,0.714907872912943,1,1,77.3,107.3,79,108.2,121,107.2,91,75.9,72.3,105.5,116.1,96.3,68.3,77.6,82.9,106.3,118.6,83.7,113,124.9,118.9,100.2,143.1,105.3,11.2,9.4,8.9,13,14.3,11.9,8.4,9.6,10.2,13.1,14.7,10.3,14,15.4,14.7,12.4,17.7,13,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q03519-1","antigen peptide transporter 2 [OS=Homo sapiens]",3,2,2,2,686,75.6,8.02,2.19,"transport;other biological processes","other membranes;ER/Golgi;nucleus","signal transduction activity or receptor binding;transporter activity;other molecular function","TAP2","ENSG00000204267; ENSG00000206235; ENSG00000206299; ENSG00000223481; ENSG00000225967; ENSG00000228582; ENSG00000232326; ENSG00000237599","","ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC","ABC transporters; Phagosome; Antigen processing and presentation; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Primary immunodeficiency",0.714,0.791,0.808,0.782,0.793,0.0811186791880256,0.409770983621107,0.461122264446451,0.0762991475729534,0.228474236608142,87.6,97.1,99.1,122.7,96,97.4,103.1,88.7,81.4,93.1,98.3,99.9,100.5,97.4,100.3,124.2,123.8,125.8,75.3,100.3,97.1,98.6,103.2,89,115.5,99.4,91.2,104.2,110.1,111.9,112.6,109.1,112.4,139.2,138.7,141,84.4,112.4,108.8,110.4,115.6,99.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P49795","Regulator of G-protein signaling 19 [OS=Homo sapiens]",5,1,1,1,217,24.6,5.62,3.2,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","RGS19","ENSG00000171700","Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells","G alpha (i) signalling events; G alpha (q) signalling events; G alpha (z) signalling events","",0.714,0.813,0.87,0.708,0.705,0.473476302336944,0.775470349279736,0.864680894003317,0.256491038658833,0.177530888728939,89.1,101.4,108.5,124.7,88.3,87.9,90.2,89.7,109.6,102.8,102.7,85.6,111.3,81.2,109.9,116,130.6,126.3,99.5,89.5,85.8,85.5,89.1,94.7,66.7,66.3,81,76,75.9,63.2,82.2,60,81.2,85.7,96.5,93.3,73.5,66.1,63.4,63.2,65.8,70,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9P031","Thyroid transcription factor 1-associated protein 26 [OS=Homo sapiens]",12,3,4,3,241,28.7,9.88,9.47,"","nucleus","","CCDC59","ENSG00000133773","","Surfactant metabolism","",0.715,0.833,0.941,0.846,0.794,0.855069264306374,1,1,1,0.738304377219864,83.7,97.4,110.1,116.9,99,92.9,77.2,106.5,81.5,111.2,95,93.4,85.7,114.2,107.3,147.4,114,95.7,114.3,96.5,96,75.6,98.1,90.5,163.2,224.9,172.2,234.8,200.6,197.2,181,241.1,226.6,311.4,240.7,202.1,241.4,203.7,202.8,159.7,207.2,191.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NXJ5","Pyroglutamyl-peptidase 1 [OS=Homo sapiens]",13,1,1,1,209,23.1,5.9,3.23,"protein metabolism","cytosol","other molecular function","PGPEP1","ENSG00000130517","","","",0.717,0.937,1.004,1.033,0.814,1,1,1,1,1,78.1,102.1,109.5,109,112.6,88.7,69.3,128.4,76.7,112.8,86.8,100.3,107.5,96.9,139.7,68.4,125.5,107,110.6,124.7,83.2,87.1,85.3,89.7,15.8,29.3,17.5,25.8,19.8,22.9,24.5,22.1,31.9,15.6,28.7,24.4,25.3,28.5,19,19.9,19.5,20.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UBY5","Lysophosphatidic acid receptor 3 [OS=Homo sapiens]",6,1,1,1,353,40.1,9.42,3.81,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","LPAR3","ENSG00000171517","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway","G alpha (i) signalling events; G alpha (q) signalling events; Lysosphingolipid and LPA receptors","Rap1 signaling pathway; Phospholipase D signaling pathway; Neuroactive ligand-receptor interaction; PI3K-Akt signaling pathway; Pathways in cancer",0.717,0.951,0.929,0.983,0.933,0.462692337538671,1,1,1,1,78,103.5,101.1,108.8,107,101.6,91.2,78,75.3,88.1,103.4,109.3,101,113.5,98.7,111.1,90.6,108.8,106.9,93.7,121.1,101.5,106.6,101.2,58.3,49.8,48.1,56.3,66.1,69.9,64.6,72.6,63.1,71,57.9,69.5,68.3,59.9,77.4,64.9,68.1,64.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UII2-1","ATPase inhibitor, mitochondrial [OS=Homo sapiens]",17,3,7,3,106,12.2,9.35,11.12,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","mitochondrion;other cell component","enzyme regulator activity;other molecular function","ATP5IF1","ENSG00000130770; ENSG00000285390; ENSPPAG00000043083; ENSPPYG00000001644; ENSPTRG00000000428","Electron transport chain: OXPHOS system in mitochondria","","",0.718,0.736,0.992,0.873,0.835,1,1,1,1,1,83.5,85.7,115.4,116.4,101.7,97.2,85.1,93.3,76.1,116.2,87.3,80.6,122.6,78,117.6,128.7,118.5,84.8,99.6,114.9,103.5,70.4,99,123.9,259.5,284.4,232.2,354.4,266.3,245.8,373.8,237.9,358.6,392.6,361.5,258.7,303.6,350.4,315.8,214.6,301.9,377.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q14934-1","Nuclear factor of activated T-cells, cytoplasmic 4 [OS=Homo sapiens]",4,3,3,1,902,95.4,5.38,4.48,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","NFATC4","ENSG00000100968; ENSG00000285485","Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Heart development; Brain-derived neurotrophic factor (BDNF) signaling pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Wnt signaling; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection; IL-18 signaling pathway","","cGMP-PKG signaling pathway; Cellular senescence; Wnt signaling pathway; Axon guidance; C-type lectin receptor signaling pathway; Oxytocin signaling pathway; Hepatitis B; Human cytomegalovirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection",0.718,0.662,0.602,0.718,0.696,1,1,0.161285889584362,0.506875789077601,0.738304377219864,97.9,90.4,82.2,136.5,98,95,107.5,97.4,96.9,89.8,132.1,77,67.7,82.2,81.7,135.7,152.5,113.8,97.4,105,71.8,105.9,94.5,91.1,12.9,11.7,11.6,10.8,15.8,9.2,8.1,9.9,9.8,16.3,18.3,13.7,11.7,12.6,8.6,12.7,11.3,10.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q70Z35-1","Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein [OS=Homo sapiens]",1,2,2,2,1606,182.5,7.44,2.42,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","enzyme regulator activity","PREX2","ENSG00000046889","Melanoma","RHOA GTPase cycle; Regulation of PTEN stability and activity; CDC42 GTPase cycle; RAC1 GTPase cycle","",0.718,0.823,0.881,0.838,0.818,0.839420910038886,1,1,1,0.44236301595155,84.9,97.2,104.1,118.2,99,96.6,83.7,86.1,107.8,98.7,101.8,86.6,105.6,107.5,96.2,114.9,119.9,121.8,109,100.5,93.9,98.1,64.4,103.6,87.9,90.5,113.2,103.6,106.9,91,110.9,112.9,101,120.7,125.9,128,114.5,105.5,98.6,103,67.7,108.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NUQ6","SPATS2-like protein [OS=Homo sapiens]",4,3,4,3,558,61.7,9.64,2.15,"","cytosol;nucleus;other cell component","","SPATS2L","ENSG00000196141","","","",0.718,0.68,0.72,0.725,0.696,0.00234240260897666,4.01947247629739E-3,5.62286746236216E-3,0.00698142057161559,0.00133286616203713,95,89.9,95.2,132.2,95.8,92,89.2,95.8,94.9,100,86.1,89.8,91.4,95.1,98.9,128.5,135.6,132.1,90.9,105.9,95.7,91.9,84.3,94,208.7,224.1,222,234,201.3,210,213.7,222.4,231.3,300.5,317.1,308.9,212.5,247.8,223.9,215,197.3,219.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q66GS9-1","centrosomal protein of 135 kDa [OS=Homo sapiens]",9,7,7,7,1140,133.4,6.21,13.13,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","other molecular function","CEP135","ENSG00000174799","","Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",0.719,0.796,0.769,0.772,0.74,0.0389756776732702,0.318290077480911,0.132149392417159,0.0872676019282145,0.0099359877555796,89.9,99.6,96.2,125.1,96.6,92.6,90.3,90.8,96.3,98.8,100.7,102,98.3,95.4,97.2,126.4,129.7,125.6,100.5,91,97.6,93.6,69.7,96,334.4,336.4,356.8,365.9,372.9,377.9,364.2,353.5,360.1,468.2,480.3,465.2,372.1,337.1,361.5,346.5,258.2,355.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P18846","Cyclic AMP-dependent transcription factor ATF-1 [OS=Homo sapiens]",9,3,5,1,271,29.2,8.37,11.08,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ATF1","ENSG00000123268","Integrated cancer pathway; Interleukin-11 signaling pathway; Myometrial relaxation and contraction pathways; EGF/EGFR signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling","NGF-stimulated transcription; CREB phosphorylation","Aldosterone synthesis and secretion; Transcriptional misregulation in cancer",0.719,0.923,0.924,0.805,0.875,0.0313181095182354,1,1,0.389234929039378,1,82.3,105.6,105.6,114.4,92,100.1,83.7,64.8,81,104,99.8,111.4,97.8,104.1,105.2,137.6,108.9,112.7,82.5,90.7,100.4,98.6,121.2,95.6,47,36.4,45.5,58.4,56.1,62.6,54.9,58.5,59.1,77.3,61.2,63.3,46.4,50.9,56.4,55.4,68.1,53.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9HCE3","Zinc finger protein 532 [OS=Homo sapiens]",16,15,26,14,1301,141.6,8.65,48.84,"","nucleus","nucleic acid binding activity;other molecular function","ZNF532","ENSG00000074657","","","",0.72,0.777,0.766,0.783,0.796,1.06053077007884E-5,0.000136781200843263,4.19426456088285e-05,6.99494459717856e-05,6.28164382706445e-05,89.2,96.3,94.9,123.9,97,98.7,92.9,89.2,88.9,94.7,96.3,98.3,91.9,94.9,96.2,126.9,123.9,123.8,97,94.6,99.2,100.2,92.6,98.7,719.6,691,688.8,733.6,745.8,761.5,712.4,735.7,745.1,983,960.3,959,751.6,732.7,768.7,776.7,717.6,764.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8WYA0-1","Intraflagellar transport protein 81 homolog [OS=Homo sapiens]",28,16,19,16,676,79.7,8.82,50.12,"cell organization and biogenesis;transport;other biological processes","cytoskeleton;other cell component","cytoskeletal activity","IFT81","ENSG00000122970","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies","Intraflagellar transport","",0.72,0.77,0.711,0.694,0.744,0.014036134097755,0.0511894135113262,0.00968729367749521,0.00698142057161559,0.00665852177874033,93.1,99.6,92,129.4,89.8,96.2,99,93.3,93.8,93.8,100.6,100.3,92.7,89.5,94.3,130.3,130.5,128.4,99,86.7,90.4,96.9,79.4,100.9,1121.8,1057.3,1062.1,1063,1139.4,1136.3,1049.9,1014.3,1068.5,1476,1478.7,1454.4,1121.4,982.3,1024.1,1097.6,899.2,1143.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O60462-1","Neuropilin-2 [OS=Homo sapiens]",3,2,2,2,931,104.8,5.17,3.8,"","","","","","","","",0.72,0.608,0.887,0.936,0.677,1,1,1,1,0.77284423946824,89.5,75.5,110.3,124.3,116.3,84.2,96.2,74.5,91.1,125.6,76.9,75.1,112.2,77.8,116.2,136.7,126.5,102.2,127.9,118.4,90.6,85.7,70.6,96.1,16.5,12.8,15.7,21.6,13.2,12.9,19.3,13.4,20,23.5,21.7,17.6,22,20.4,15.6,14.7,12.1,16.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","O75541","zinc finger protein 821 [OS=Homo sapiens]",2,1,1,1,412,46.8,6.55,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF821","ENSG00000102984","","","",0.72,1.256,1.112,1.191,0.967,1,1,1,1,1,69.2,120.7,106.8,96.1,114.4,92.9,64.3,107.9,67,135.2,116.8,100.8,82.1,111.4,103.4,93,150.1,64.5,110.8,85.6,121.5,70.4,125.2,89.9,8.6,14.4,8.9,18.1,15.6,13.5,11,14.9,13.8,12.4,20,8.6,14.8,11.4,16.2,9.4,16.7,12,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q9BZ19","ankyrin repeat domain-containing protein 60 [OS=Homo sapiens]",3,1,1,1,345,37.6,8.95,2.06,"","","","ANKRD60","ENSG00000124227","","","",0.72,0.79,0.73,0.663,0.795,1,1,1,1,0.811467967146757,92,100.8,93.3,127.7,84.7,101.6,118.9,86.4,98.2,90.7,108.5,107.7,99.6,49.5,102.8,155.3,136.4,131.6,90.5,93.2,73.7,108.5,33.9,114.6,72.9,53,60.2,55.6,66.6,66,61.1,30.4,63,95.2,83.6,80.7,55.5,57.2,45.2,66.5,20.8,70.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96BU1-1","S100P-binding protein [OS=Homo sapiens]",11,2,2,2,408,45.6,5.17,0,"","cytosol;nucleus","other molecular function","S100PBP","ENSG00000116497","","","",0.721,0.882,0.603,0.697,0.69,0.177715303160298,1,0.0951892088829182,0.0684452328627458,0.201541890373644,94.2,115.2,78.8,130.6,91.1,90.2,96.8,82.7,94.2,98.7,115.2,121.4,78.8,105,72.4,127.8,130.7,143.9,94.5,91.1,68.8,90.2,98.2,89.5,17.9,15.3,17.4,18.2,21.3,22.4,14.6,19.4,13.4,23.6,24.1,26.6,17.5,16.8,12.7,16.7,18.1,16.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q52WX2","Serine/threonine-protein kinase SBK1 [OS=Homo sapiens]",2,1,1,1,424,46.2,9.1,2.27,"protein metabolism;other metabolic processes","other cell component","kinase activity;other molecular function","SBK1","ENSG00000188322","","","",0.721,0.661,0.678,0.651,0.678,1,1,1,0.77191531709215,0.911258048591279,98.6,90.4,92.7,136.7,89,92.6,89.4,96.1,102.6,88.1,133.2,81.9,118.4,90.3,64.1,142.5,120.5,133.2,86.7,99.8,72.1,71.6,119.4,90.3,17.8,19.1,20.4,17.6,26.5,16.3,23.6,18,12.8,28.4,24,26.5,17.3,19.9,14.4,14.3,23.8,18,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","Q56P03","e2f-associated phosphoprotein [OS=Homo sapiens]",3,1,1,1,285,32.7,5.12,0,"other biological processes","nucleus;other cell component","","EAPP","ENSG00000129518","","","",0.721,0.819,0.956,0.839,1.159,1,1,1,1,1,78.8,89.5,104.4,109.2,91.6,126.5,82.8,84.5,116.8,74.6,105.3,95.9,123.6,63.6,111.9,124,117.1,99.2,62.9,124.6,98.2,138.1,41.1,135.7,10.3,10.5,14.5,9.2,13,11.9,15.3,7.9,13.9,15.3,14.5,12.3,7.8,15.4,12.2,17.1,5.1,16.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O95864","fatty acid desaturase 2 [OS=Homo sapiens]",16,7,10,7,444,52.2,8.82,19.47,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","FADS2","ENSG00000134824","PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis","alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","alpha-Linolenic acid metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway",0.722,0.779,0.721,0.732,0.693,0.000838437183136541,0.0125695208029839,0.00142446482230374,3.4846411798998E-3,0.000782069063529306,93.2,100.6,93.1,129.1,94.5,89.5,86.3,96.8,93.1,101.3,95.7,100.5,93.1,95.1,88.5,125.3,129.7,129,102.7,94.4,93.8,89.4,86.6,98.6,365.5,410.1,394.3,429,405.5,425.6,394.1,403,374.8,530.9,549.1,546.5,434.9,399.8,397.4,378.7,367,417.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96PY6-1","Serine/threonine-protein kinase Nek1 [OS=Homo sapiens]",3,2,2,2,1258,142.7,5.94,5.28,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","NEK1","ENSG00000137601","Ciliopathies","","",0.722,0.882,0.907,0.879,0.719,0.575633056353018,1,1,1,0.778791724797922,84.8,103.6,106.5,117.4,103.2,84.5,73,83.4,101.2,101.8,112.3,93,104.7,91.4,105.8,125.3,98.7,115.5,125.1,101.4,98.4,104.3,81.6,83.1,13.9,15.9,19.3,19.4,21.4,17.7,19.9,17.4,20.1,23.9,18.8,22,23.8,19.3,18.7,19.9,15.5,15.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","P18827","syndecan-1 [OS=Homo sapiens]",4,1,1,1,310,32.4,4.63,0,"cell-cell signaling;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SDC1","ENSG00000115884","","Cell surface interactions at the vascular wall; Syndecan interactions; A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport; Other interleukin signaling","ECM-receptor interaction; Cell adhesion molecules; Malaria; Proteoglycans in cancer; Fluid shear stress and atherosclerosis",0.722,0.784,0.839,0.72,0.67,0.0532874840874838,0.396887772117488,0.54119720275206,0.0685127448042977,0.0360242855584617,91.5,99.3,106.3,126.7,91.3,84.9,82.8,90.4,93.1,98.1,97.9,99.5,117,88.4,105,125.1,154.1,118.5,82.9,97.8,90.1,83.9,78.3,97.1,44.3,48.3,49.8,52.4,52.3,53.2,62.6,47.2,56.1,66.9,82.4,63.3,44.3,52.3,48.2,44.8,41.9,51.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q99666","RANBP2-like and GRIP domain-containing protein 5/6 [OS=Homo sapiens]",22,37,115,1,1765,198.8,6.42,239.39,"transport;other biological processes","nucleus;other cell component","","RGPD5; RGPD6","ENSG00000015568; ENSG00000183054","","","",0.723,0.761,0.721,0.708,0.646,0.00875349051489771,0.130439716952135,0.0277844734047657,0.0124484974394233,0.00665852177874033,95.1,100.1,94.9,131.6,93.2,85,96,81.5,95,99.3,100,103.1,94.8,93.6,95.5,129.7,135.1,131.5,93.1,96.2,86.9,84.9,79.6,104.4,149.4,126.9,147.9,154.5,155.7,160.5,147.6,145.7,148.6,201.9,210.3,204.7,144.9,149.8,135.3,132.2,123.9,162.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q06609","DNA repair protein RAD51 homolog 1 [OS=Homo sapiens]",5,1,2,1,339,36.9,5.6,5.49,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD51","ENSG00000051180","miRNA regulation of DNA damage response; Homologous recombination; ATM signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; DNA repair pathways, full network; DNA damage response","Resolution of D-loop Structures through Holliday Junction Intermediates; Transcriptional Regulation by E2F6; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination; HDR through Single Strand Annealing (SSA)","Homologous recombination; Fanconi anemia pathway; Pathways in cancer; Pancreatic cancer",0.723,0.742,0.598,0.772,0.706,0.716100502773102,1,0.178959220617982,0.901124372578101,0.463809853930963,95.6,98,79,132.1,102,93.2,97.7,103.8,86.1,108.6,80.3,100.2,80.8,72.1,83.3,135,123.9,147.5,111.3,82.1,104.3,66.3,121.5,95.3,43.9,46.7,38.7,48.8,36.1,45,36.3,32.4,37.4,60.7,55.7,66.3,50,36.9,46.9,29.8,54.6,42.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P51965-1","Ubiquitin-conjugating enzyme E2 E1 [OS=Homo sapiens]",32,5,28,3,193,21.4,8.53,72.85,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LOC101359889; LOC101586133; LOC102160336; LOC102380731; LOC102540481; LOC112397773; LOC112849581; Ube2e1; UBE2E1","ENSAMEG00000003515; ENSANAG00000034758; ENSCAFG00000005774; ENSCANG00000033360; ENSCATG00000032614; ENSCPOG00000002251; ENSCPRG00005002140; ENSCSAG00000009770; ENSG00000170142; ENSGGOG00000008393; ENSLAFG00000004150; ENSLCNG00005011685; ENSMLEG00000038400; ENSMNEG00000039247; ENSNLEG00000003557; ENSOANG00000044336; ENSOCUG00000006026; ENSOGAG00000007527; ENSPANG00000031728; ENSPCOG00000023739; ENSPPAG00000039295; ENSPPYG00000014067; ENSPTXG00000015919; ENSRBIG00000034290; ENSRFEG00010011222; ENSRROG00000029547; ENSSBOG00000027996; ENSSSCG00000026488; ENSSSCG00070018080; ENSSSUG00005002544; ENSSTOG00000025799; ENSUAMG00000015531; ENSUMAG00000018601; ENSVVUG00000028240","Photodynamic therapy-induced unfolded protein response; 7q11.23 copy number variation syndrome","Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Separation of Sister Chromatids; ISG15 antiviral mechanism; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Phosphorylation of the APC/C; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; ISG15 antiviral mechanism; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Ubiquitin mediated proteolysis",0.723,0.811,0.714,0.749,0.726,4.80854936940976e-05,0.00301153559025353,5.39365964214549e-05,7.92635346912381e-05,6.36055568464656e-05,91.9,103,90.7,127,95.1,92.2,91.8,88.3,96.2,102.9,101,104,90.6,95.6,88.5,127.7,126.9,124.3,90.3,95.8,95,96.8,92.1,92,839.1,806.6,879.2,940.8,923.5,950.9,828.5,873.6,808.8,1167.4,1160.1,1135.8,825.3,876,868.6,884.9,841.8,841.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","A6NMB9","Putative fidgetin-like protein 2 [OS=Homo sapiens]",1,1,1,1,653,66.6,6.73,1.79,"cell organization and biogenesis","nucleus","other molecular function","FIGNL2","ENSG00000261308","","","",0.723,0.741,0.845,0.929,0.734,1,1,1,1,0.785129484314969,87.3,89.4,101.9,120.6,112.1,88.6,79.4,87.6,103.1,105.4,89.7,80.2,115.3,80.9,102.3,121.1,127.1,107.8,119.7,102.2,112.5,114.5,88.9,62.3,22.7,25,29.4,30.1,25.6,22.9,32.9,23.1,29.2,34.6,36.3,30.8,34.2,29.2,32.1,32.7,25.4,17.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q15651-1","High mobility group nucleosome-binding domain-containing protein 3 [OS=Homo sapiens]",9,1,3,1,99,10.7,9.66,5.8,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN3","ENSCANG00000002658; ENSCATG00000032172; ENSG00000118418; ENSGGOG00000006910; ENSMLEG00000006684; ENSMNEG00000036715; ENSPANG00000015740; ENSPTRG00000018366; ENSRROG00000040340","","","",0.724,0.909,0.905,1.017,0.769,0.110077989270625,1,1,1,0.714047848481029,81.6,102.4,102,112.7,114.7,86.6,86.5,83,68,104.2,93.4,110.9,111.1,96.4,103.8,114.6,122.4,97.9,121.1,116.7,96.3,88.2,87.3,98.2,48.8,46.8,38.4,58.8,52.7,62.6,62.7,54.4,58.6,64.7,69.1,55.2,68.3,65.8,54.3,49.8,49.3,55.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8IZD2-1","Histone-lysine N-methyltransferase 2E [OS=Homo sapiens]",1,1,1,1,1858,204.8,7.61,2.76,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","KMT2E","ENSG00000005483","Histone modifications","RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; PKMTs methylate histone lysines","Lysine degradation; Metabolic pathways",0.724,0.789,0.651,0.911,0.911,0.547231847260093,1,0.350416956859955,1,1,87.1,94.9,78.4,120.3,109.6,109.6,89.2,100.8,71.9,96.1,97.2,108.6,87.2,78.1,80.3,124.1,93.5,123.3,112.6,112.3,98.2,112.3,96.7,117.9,18,20.3,14.5,19.4,19.6,21.9,17.6,15.7,16.2,25,18.8,24.8,22.7,22.6,19.8,22.6,19.5,23.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q86WP2-1","Vasculin [OS=Homo sapiens]",2,1,1,1,473,53.3,7.05,2.89,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","GPBP1","ENSG00000062194; ENSGGOG00000008390","","","",0.724,0.779,0.586,0.66,0.778,1,1,1,0.932083710741393,1,95.9,103.3,77.7,132.5,87.4,103.1,107.2,83.2,94.5,101.9,101.7,89.8,124.1,76.5,71.4,168.8,92.7,130.5,86.1,94.9,80.6,101.6,80.1,114.4,70.4,54.6,62,66.9,66.8,59,81.5,50.2,46.9,110.9,60.9,85.7,56.5,62.3,52.9,66.7,52.6,75.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q6IE81-1","Protein Jade-1 [OS=Homo sapiens]",11,9,13,9,842,95.5,7.91,16.05,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","JADE1","ENSG00000077684; ENSPPAG00000027693; ENSPTRG00000016439","","HATs acetylate histones","",0.724,0.722,0.737,0.717,0.734,3.42430608072887e-05,0.000135609895036388,7.37834272791172e-05,4.65767079886207e-05,6.26430836766659e-05,93.8,93.5,95.4,129.5,92.9,95,94.1,90.2,93.5,90.5,99.6,93.2,95.1,91.3,96.2,131.9,128.5,129.1,96.3,92.6,92,99.4,91.8,94.8,552.5,529.9,549.3,531.5,584.9,547.5,558.7,536.3,564.9,774.8,754.6,758.6,566,544,540.7,583.8,539,556.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y5J1","U3 small nucleolar RNA-associated protein 18 homolog [OS=Homo sapiens]",25,11,31,11,556,62,8.76,68.25,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","UTP18","ENSG00000011260","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",0.725,0.779,0.77,0.729,0.795,0.0016684902939001,0.0127907268566163,0.00679660961118237,0.000651104987852897,0.00780413208539006,90.6,97.5,96.3,125.1,91.2,99.4,91.1,90.7,99.3,94.8,100.3,98,98.5,96.8,95.6,126.3,118.8,125.8,91.7,82.9,94,101.7,99.9,93.7,1276.4,1269.7,1391.2,1328.2,1404,1372.9,1379.6,1356.1,1338.1,1768.2,1663.6,1761.5,1284.1,1160.4,1316.8,1424,1399.6,1311.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96MT3","Prickle-like protein 1 [OS=Homo sapiens]",7,4,4,4,831,94.2,6.24,5.53,"cell-cell signaling;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;nucleus","other molecular function","PRICKLE1","ENSG00000139174","Wnt signaling","Asymmetric localization of PCP proteins","Wnt signaling pathway",0.725,0.883,0.751,0.755,0.715,0.0255827147048215,1,0.193988506004021,0.0872676019282145,0.0115053757376935,90,109.7,93.3,124.3,93.8,88.9,90.8,92.2,84.4,103.9,110.6,111.7,93.7,94.1,105,120.7,125.6,125.3,98.1,91.4,94.6,96.5,71.7,89.7,102.2,103.8,95,116.9,124.5,125.7,105.4,105.8,118.2,135.8,141.3,141,110.4,102.9,106.5,108.5,80.7,100.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y692-1","Glucocorticoid modulatory element-binding protein 1 [OS=Homo sapiens]",17,8,12,7,573,62.6,4.83,30.46,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GMEB1","ENSG00000162419; ENSGGOG00000009221; ENSPPAG00000038756","","","",0.725,0.776,0.718,0.723,0.741,0.0169110220164363,0.171703426323129,0.0277844734047657,0.021502541423799,0.0238055502254859,92.8,99.4,92,128.1,92.7,94.9,93.3,86.6,98.6,103.8,96.9,99.8,89.9,98.3,92.5,128.7,117,130.3,93.1,89.5,98.5,103.8,84.1,95.3,550.9,511.8,582.7,613.1,572.4,589.8,531.2,580.9,546.2,760.2,691.1,769.5,549.9,528.4,581.8,613,496.6,563.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8WXG9-1","G-protein coupled receptor 98 [OS=Homo sapiens]",1,4,5,4,6306,692.6,4.64,5.69,"cell adhesion;cell organization and biogenesis;protein metabolism;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","ADGRV1","ENSG00000164199","GPCRs, other","EGR2 and SOX10-mediated initiation of Schwann cell myelination","",0.726,0.823,0.874,0.872,0.867,1,1,1,1,1,84.4,95.7,101.5,116.2,101.4,100.8,74.2,108.8,85.3,96.7,106.4,88.9,97,111.8,102.7,122.1,86.2,117.5,102.5,86,111.6,101.9,96.4,104,28.3,41.5,32.5,36.9,40.6,33.9,37,42.6,39.2,46.6,32.9,44.8,39.1,32.8,42.6,38.9,36.8,39.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8TF39","Zinc finger protein 483 [OS=Homo sapiens]",20,13,25,11,744,85,8.57,35.62,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF483","ENSG00000173258","","Generic Transcription Pathway","",0.727,0.697,0.681,0.683,0.687,1.81779680500148E-3,0.00137731433159294,0.000557128712598862,0.000617279871629411,0.000155120504922677,97.4,93.4,91.3,134.1,91.6,92.2,99.4,98.3,98.4,94.4,94.6,91.7,92.3,88.3,92.3,134.5,135.5,137.7,92.5,95.5,90.9,94,76.6,93.1,1517.8,1502.1,1503.8,1442,1445.2,1401.6,1410.2,1349.2,1410,2055.1,2069.9,2104.1,1413.2,1458.6,1388.1,1435.4,1169.6,1422.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P09651-2","Isoform A1-A of Heterogeneous nuclear ribonucleoprotein A1 [OS=Homo sapiens]",80,23,451,1,320,34.2,9.23,1033.32,"","","","HNRNPA1","","","","",0.727,0.774,0.879,0.733,0.757,1,1,1,1,1,89.6,95.4,108.3,123.2,90.3,93.2,70.6,96.7,83.5,108.9,74.5,88.9,100.9,120.4,71.3,114.8,113.6,122,75.6,84.1,107.3,86.9,202.3,77.6,37.9,52,44.8,58.5,40,47.8,54.2,64.7,38.3,61.7,61,65.5,40.6,45.2,57.6,46.7,108.7,41.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P80723","Brain acid soluble protein 1 [OS=Homo sapiens]",48,6,7,6,227,22.7,4.63,15.61,"developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","BASP1","ENSG00000176788","","RHOF GTPase cycle","",0.727,0.862,1.122,1.185,1.202,1,1,1,1,1,71.6,84.8,110.4,98.4,116.6,118.2,79.7,72,60.8,130.6,85.3,74.1,120.4,90.7,111.2,169,99,65.8,118.6,117.4,104.2,61.1,120.8,119,151.6,137,115.7,248.3,162.3,141,229,172.5,211.4,321.5,188.4,125.1,225.6,223.2,198.2,116.3,229.7,226.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9BT67","NEDD4 family-interacting protein 1 [OS=Homo sapiens]",13,2,3,2,221,24.9,4.68,7.2,"protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","NDFIP1","ENSG00000131507","","","",0.728,0.714,0.732,0.744,0.767,0.0339602130471722,0.0363411342792753,0.0617111898807095,0.0570259225908572,0.12668828555071,93.3,91.4,93.7,128.1,95.3,98.3,86.2,100.6,92.9,99.8,91.1,80.7,93.3,92.8,97.5,116.4,127.6,136,88.9,94.9,102.9,97.9,104.9,95.7,86.6,101,93.3,100.2,91.5,81,93.8,93.3,97.9,117,128.2,136.6,89.3,95.3,103.3,98.4,105.4,96.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8TC59-1","piwi-like protein 2 [OS=Homo sapiens]",3,3,4,3,973,109.8,8.98,11.32,"cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PIWIL2","ENSG00000197181","Male infertility","PIWI-interacting RNA (piRNA) biogenesis","",0.729,0.758,0.771,0.694,0.742,0.000857163560025572,0.00717226437471812,0.0115962237820142,0.0013346156060942,0.00375994348478588,93.1,96.9,98.6,127.8,88.7,94.8,95.1,84.4,93,96.8,92.3,97.8,98.4,101.5,96.7,127.6,119.8,132.8,88.6,87.9,99,94.7,94.7,99.2,301.8,267.8,295.2,307.1,293,310.3,312.3,322.2,306.8,405.1,380.1,421.3,281,278.9,314.2,300.5,300.4,314.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P54760","Ephrin type-B receptor 4 [OS=Homo sapiens]",17,13,14,11,987,108.2,6.9,25.79,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","EPHB4","ENSG00000196411","Vitamin D receptor pathway; Neovascularisation processes; Neural crest cell migration during development; Neural crest cell migration in cancer","EPHB-mediated forward signaling; Ephrin signaling; EPH-ephrin mediated repulsion of cells","Axon guidance",0.729,0.817,0.794,0.82,0.805,4.28226456679672e-06,9.60827090240317e-05,4.4182832920425e-05,0.000156464800322171,4.80563780673165e-05,88.1,98.7,95.9,120.9,99.1,97.3,89.5,87.4,88.6,100,99.3,91.8,96.5,95.4,96.5,119.2,121.6,122.2,99.4,99.7,100.4,96.4,97.8,98.4,476,464.9,471.4,532,528.5,488.5,513.7,507.6,513.3,634.4,646.8,650.3,528.8,530.6,534,512.9,520.6,523.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q68DK2","Zinc finger FYVE domain-containing protein 26 [OS=Homo sapiens]",1,2,3,1,2539,284.4,6.39,3.99,"cell cycle OR cell proliferation;DNA metabolism;stress response;other biological processes","cytoskeleton;other cell component","other molecular function","ZFYVE26","ENSG00000072121","","","",0.729,0.805,1,0.768,0.915,0.727987522133649,1,1,0.999034077761899,1,83.8,92.6,115,115,88.4,105.2,78.2,84.8,85.9,131.2,93.6,71,116.3,131.2,101.4,103.7,120,116.3,93.1,76.8,89.4,93.8,106.4,106.9,13.1,14.2,14.4,22,15.7,11.9,19.5,22,17,17.3,20.1,19.5,15.6,12.9,15,15.7,17.8,17.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P36894","Bone morphogenetic protein receptor type-1A [OS=Homo sapiens]",6,2,3,2,532,60.2,7.58,11.03,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;kinase activity;other molecular function","BMPR1A","ENSG00000107779","Bone morphogenic protein (BMP) signaling and regulation; Heart development; Endoderm differentiation; Mesodermal commitment pathway; Ectoderm differentiation; Mesodermal commitment pathway; Ectoderm differentiation; Canonical and non-canonical TGF-B signaling; Embryonic stem cell pluripotency pathways; Endochondral ossification; Osteoblast differentiation and related diseases; Endochondral ossification with skeletal dysplasias; Development of ureteric collection system; Orexin receptor pathway","Signaling by BMP","Cytokine-cytokine receptor interaction; TGF-beta signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Fluid shear stress and atherosclerosis",0.73,0.773,0.724,0.673,0.66,0.234140898735711,0.700987510834969,0.226760068939436,0.0422108042402246,0.0253491772746935,96,101.8,95.3,131.6,88.5,86.9,101.6,94,97.1,104.9,102.8,100.4,96.4,96.3,93.8,141.3,133,128.9,89.5,95.8,73.1,87.8,64.5,98.8,87.2,80.6,83.3,90,88.2,86.1,82.7,82.6,80.5,121.2,114.1,110.6,76.7,82.2,62.7,75.3,55.3,84.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UHC6-1","Contactin-associated protein-like 2 [OS=Homo sapiens]",3,2,3,1,1331,148.1,6.58,10.03,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CNTNAP2","ENSG00000174469; ENSG00000278728","","","Cell adhesion molecules",0.73,0.76,0.759,0.718,0.746,0.278774233927466,1,0.939181590987783,0.468412313303839,0.258278228586557,93,96.8,96.6,127.3,91.3,95,93.5,86.4,91.3,122.3,95.1,93.6,94.9,117.7,85.3,129.5,112.1,125,105,87.6,89.7,84,93.3,93.5,123.6,114.2,120.6,161.6,125.6,123.7,125.4,155.6,112.7,171.1,148.1,165.2,138.8,115.8,118.5,111.1,123.2,123.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y3X0","coiled-coil domain-containing protein 9 [OS=Homo sapiens]",11,5,7,5,531,59.7,5.4,15.69,"","","","CCDC9","ENSG00000105321","IL-18 signaling pathway","","",0.731,0.85,0.93,0.927,1.018,0.643689463911243,1,1,1,1,80.4,93.5,102.2,110,101.9,111.9,80.1,80.4,77.7,83.1,105.7,93.1,101.8,103.8,98.4,150.6,109.5,81.1,119.3,90.1,101.5,113.7,111.5,98.4,200,200.7,193.9,207.4,263.9,232.5,254.2,259.1,245.7,375.9,273.4,202.5,297.7,224.8,253.4,283.9,278.2,245.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q6ZNL6-1","FYVE, RhoGEF and PH domain-containing protein 5 [OS=Homo sapiens]",7,6,7,6,1462,159.8,5.01,9.55,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","FGD5","ENSG00000154783","VEGFA-VEGFR2 signaling pathway","RAC1 GTPase cycle","",0.731,0.777,0.891,0.825,0.823,0.526266523468151,1,1,1,1,86.9,92.4,105.9,118.9,98.1,97.8,84.1,84.4,92.7,101.2,89.6,85.8,102.8,118.6,94.5,121.3,103.9,115.4,99.3,95.2,92.6,90,133.9,94.9,86,86.3,94.8,103.5,91.6,87.7,105.1,121.3,96.7,124,106.2,118,101.6,97.3,94.6,92.1,136.9,97,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8NEY1","neuron navigator 1 [OS=Homo sapiens]",17,24,41,24,1877,202.3,8.07,87.32,"cell organization and biogenesis;developmental processes","cytoskeleton;other cell component","","NAV1","ENSG00000134369","","","",0.731,0.802,0.761,0.794,0.792,0.000780547421087728,0.0123964600068832,0.00274943679927359,0.00539801417398927,3.29683404973917E-3,89.9,98.6,93.5,123,97.6,97.4,89.4,93,90.2,94.7,99.6,98.8,93.7,93.8,93.8,133.1,117,123.3,97.8,93.3,100.5,97.6,88.8,101.6,1363.8,1418.3,1374.7,1443.2,1519,1507.2,1428.2,1429.8,1430.9,2029.8,1783.8,1879.4,1491.5,1422.2,1532.3,1488.7,1354.5,1548.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9BSH4","Translational activator of cytochrome c oxidase 1 [OS=Homo sapiens]",12,2,8,2,297,32.5,8.13,5.43,"cell organization and biogenesis;other biological processes","mitochondrion","translation activity;nucleic acid binding activity","TACO1","ENSG00000136463","Mitochondrial complex IV assembly","TP53 Regulates Metabolic Genes; Respiratory electron transport; Cytoprotection by HMOX1","",0.733,1.026,0.954,1.015,0.887,1,1,1,1,1,78.3,109.6,101.9,106.9,108.5,94.8,68,117.5,75,124,84.6,105,88.1,147.1,97.6,88.7,108.5,102.3,112.3,91.1,103.8,72.1,123.6,90.8,82,141.8,90.5,149.8,102.1,126.7,106.4,177.6,117.8,107.1,131,123.6,135.6,110,125.4,87.1,149.3,109.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q01974","Tyrosine-protein kinase transmembrane receptor ROR2 [OS=Homo sapiens]",3,3,3,2,943,104.7,6.55,0,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ROR2","ENSG00000169071","Cardiac progenitor differentiation; Ectoderm differentiation; Wnt signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma","WNT5A-dependent internalization of FZD2, FZD5 and ROR2","Wnt signaling pathway",0.733,0.842,0.812,0.749,0.752,0.12100536336198,1,1,0.404504740674306,0.586784372504023,90,103.4,99.6,122.7,92,92.3,75.9,92.3,94,106,95.6,106.4,91.3,102.2,108.5,102.3,125.9,127,94.3,89.4,97.2,94.7,90.7,106.5,86,104.6,106.6,120.2,108.3,120.6,103.4,115.8,122.9,115.9,142.7,143.9,106.9,101.3,110.2,107.3,102.8,120.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9BQT9","Calsyntenin-3 [OS=Homo sapiens]",3,3,3,3,956,106,5.44,6.88,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","CLSTN3","ENSG00000139182; ENSG00000288427","","","",0.733,0.874,0.878,0.774,0.868,0.0764980597945484,1,1,0.10386461823871,0.660707865284593,85.8,102.2,102.7,117,90.6,101.6,85.4,78.5,100,101.2,112.5,101.8,100.6,105.4,102.3,116.6,116.5,114.2,80.3,90.2,96.7,101.2,106.3,90.4,109,100.2,127.7,129.1,143.6,129.9,128.4,134.5,130.5,148.8,148.7,145.7,102.4,115,123.3,129.1,135.6,115.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","P05187","alkaline phosphatase, placental type [OS=Homo sapiens]",2,1,1,1,535,57.9,6.29,0,"other metabolic processes","plasma membrane;other membranes;other cell component","other molecular function","ALPP","ENSG00000163283","Orexin receptor pathway","Intra-Golgi traffic","Thiamine metabolism; Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors",0.734,0.926,0.838,0.82,0.838,1,1,1,1,0.968850063191466,85.4,107.8,97.5,116.4,95.4,97.5,98.4,87.1,79.9,111.8,109.9,102.3,96.5,99.4,115,94.1,118.7,125.3,99.3,90.5,97.3,99.4,67.9,106.9,87.1,77.1,70.8,99,97.3,90.6,85.4,88,101.8,83.3,105,110.9,87.9,80.1,86.1,88,60.1,94.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8N0X7","Spartin [OS=Homo sapiens]",30,16,35,16,666,72.8,5.91,85.14,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","SPART","ENSG00000133104","","","Endocytosis",0.734,0.618,0.588,0.554,0.575,2.04419942829002E-4,1.87907267551468E-5,5.14180303384396e-06,1.66266075369431E-6,2.94974242872773e-06,108.3,91.1,86.7,147.5,81.7,84.7,108.8,109.6,104.3,93.7,91.5,89.4,86.1,87.5,87.1,152.3,136.7,148.2,82.1,78.5,87.7,86.4,85.1,84.9,1538,1549.5,1474.2,1324.8,1293.9,1263.9,1217.1,1237.5,1231.2,2152.8,1933.1,2095.2,1160.9,1109.8,1239.8,1221.9,1203.8,1200.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P17302","Gap junction alpha-1 protein [OS=Homo sapiens]",22,6,21,6,382,43,8.76,49.6,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;cytoskeletal activity;other molecular function","GJA1","ENSG00000152661","Genes targeted by miRNAs in adipocytes; Arrhythmogenic right ventricular cardiomyopathy; Corticotropin-releasing hormone signaling pathway; Spinal cord injury; Myometrial relaxation and contraction pathways; Wnt signaling pathway; VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway; 1q21.1 copy number variation syndrome; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways","Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; RHOQ GTPase cycle; RHOJ GTPase cycle; Oligomerization of connexins into connexons; Transport of connexins along the secretory pathway; Formation of annular gap junctions; Regulation of gap junction activity","Gap junction; Arrhythmogenic right ventricular cardiomyopathy",0.735,0.826,0.853,0.912,0.899,0.00399137371016276,0.258390423511703,0.320834765888467,0.854128498232421,0.417135336598687,84.4,94.8,97.9,114.8,104.8,103.3,85.2,81.5,86.3,95.8,99.3,95.7,99.9,98.9,97.1,111.8,116,117.8,105.8,109.7,95.6,90,109.4,104.3,822,785.8,832.1,924.1,957.5,923.1,963.9,954.4,936.6,1078,1118.9,1136,1020.7,1057.9,922.4,868.3,1055,1006.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O14730","serine/threonine-protein kinase RIO3 [OS=Homo sapiens]",8,4,5,4,519,59.1,5.76,6.55,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;other cell component","kinase activity;other molecular function","RIOK3","ENSG00000101782","","Major pathway of rRNA processing in the nucleolus and cytosol","",0.735,0.868,0.873,0.789,0.832,1.15661499543418E-3,0.671550180650092,0.301005413060539,0.0131595761064015,0.123104983926414,86.5,102.2,102.7,117.7,92.9,97.9,86.7,88,84.1,101.4,102.4,106.8,103,103.3,98.7,108.6,118.6,118,93.1,91.3,95.9,108.6,93.5,98.1,124.8,126.7,121.1,146,147.4,153.7,148.2,148.8,142.1,156.3,170.7,169.8,134.1,131.4,138,156.3,134.5,141.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q7Z3T8","Zinc finger FYVE domain-containing protein 16 [OS=Homo sapiens]",2,3,3,3,1539,168.8,4.82,8.45,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ZFYVE16","ENSG00000039319","TGF-beta signaling pathway","Signaling by BMP","Endocytosis; TGF-beta signaling pathway",0.735,0.784,0.79,0.8,0.887,0.770832003300418,1,1,1,1,88.3,94.1,94.9,120.1,96,106.6,87,82.1,96.3,106.3,92.8,88.4,92.6,93.5,122,118.4,130.7,92.4,104.4,94.7,84.7,111.3,97.3,105.1,37.2,35.1,41.2,45.4,39.7,37.8,39.6,40,52.2,50.6,55.9,39.5,44.6,40.5,36.2,47.6,41.6,44.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P98155-1","very low-density lipoprotein receptor [OS=Homo sapiens]",4,3,4,3,873,96,4.79,7.28,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","VLDLR","ENSG00000147852","Familial hyperlipidemia type 3","VLDLR internalisation and degradation; Reelin signalling pathway; VLDL clearance","Spinocerebellar ataxia; Lipid and atherosclerosis",0.736,0.759,0.696,0.699,0.677,1.6103062419119E-3,0.00856948957572323,0.000917948365647908,6.90298431320233E-4,0.000290611926339138,96.7,99.7,91.4,131.4,91.9,88.9,92.9,97.3,98.5,92.4,106.1,100.3,95.8,91.9,88.3,132.2,123,139.1,88.1,92.4,94.9,85.7,91.7,89.5,234.8,246.1,249,233.6,268.1,253.7,242.1,232.4,223.3,334.2,310.9,351.6,222.8,233.7,240,216.6,231.7,226.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O95905","Protein ecdysoneless homolog [OS=Homo sapiens]",21,9,9,9,644,72.7,4.87,11.41,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ECD","ENSG00000122882","","","",0.736,0.734,0.735,0.747,0.861,1.17302957221512E-3,3.19372178235151E-3,1.89083057836516E-3,0.00124566556513236,0.354530411833083,91.8,91.5,91.6,124.7,93.1,107.3,92.5,91.4,92.3,94.1,91.4,92,87.2,96.9,92,125.3,115.3,125.8,94.9,86.2,93.6,105.5,107.9,115.7,221.9,219.3,221.5,225.8,219.2,220.8,209.3,232.6,220.9,300.7,276.7,301.8,227.8,206.9,224.5,253.1,258.9,277.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q13573","SNW domain-containing protein 1 [OS=Homo sapiens]",19,10,17,10,536,61.5,9.52,28.8,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SNW1","ENSG00000100603","TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; mRNA Splicing - Major Pathway; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling","Spliceosome; Notch signaling pathway; Epstein-Barr virus infection; Viral carcinogenesis",0.738,0.934,0.891,0.898,0.81,0.740167547047334,1,1,1,1,84,106.3,101.4,113.9,102.2,92.2,73.7,82.9,79.1,100.1,107.5,91.5,95.5,99.2,94.7,206,107.2,81.6,124.3,96.2,88.9,98,86.8,86.7,445.6,500.9,477.8,604.8,649.3,553.1,576.8,599.5,572.4,1244.7,647.7,493.2,750.9,581.5,537.1,592.3,524.6,523.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P84022","Mothers against decapentaplegic homolog 3 [OS=Homo sapiens]",10,4,8,1,425,48.1,7.15,23.23,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","SMAD3","ENSG00000166949","Androgen receptor signaling pathway; Cell cycle; AGE/RAGE pathway; Adipogenesis; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Ovarian infertility; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularisation processes; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; TGF-beta receptor signaling; DNA damage response (only ATM dependent)","Ub-specific processing proteases; Interleukin-37 signaling; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX3 regulates BCL2L11 (BIM) transcription; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates CDKN1A transcription; NOTCH4 Intracellular Domain Regulates Transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer","FoxO signaling pathway; Cell cycle; Endocytosis; Cellular senescence; Wnt signaling pathway; TGF-beta signaling pathway; Apelin signaling pathway; Hippo signaling pathway; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Th17 cell differentiation; AGE-RAGE signaling pathway in diabetic complications; Hepatitis B; Human T-cell leukemia virus 1 infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer; Chronic myeloid leukemia; Hepatocellular carcinoma; Gastric cancer; Inflammatory bowel disease; Diabetic cardiomyopathy",0.738,0.82,0.804,0.815,0.797,0.00188097024923098,0.0561917959570644,0.0260392659061161,0.0253740755760614,0.0166394991640174,89.1,98.9,97,120.6,98.3,96.1,96.2,85.9,88.7,94.8,98.5,102.7,96.7,94,101.2,120.2,112.5,124.3,97.9,97.9,98,102.2,92.6,95.8,186.2,166.3,171.7,183.5,190.7,198.7,187.1,181.9,195.8,232.6,217.6,240.5,189.5,189.4,189.7,197.7,179.2,185.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q86UA6-1","RPA-interacting protein [OS=Homo sapiens]",3,1,1,1,219,24.8,4.94,1.64,"","","","","","","","",0.738,0.93,0.756,0.811,0.692,1,1,1,1,0.741634541261464,89.9,113.2,92,121.8,98.7,84.3,89.3,86.5,111.4,115.7,87.8,112.5,90.6,108.7,91.4,121,127,106.6,114.3,98.1,71.4,83.7,83.7,100.3,33.1,32,41.3,42.9,32.5,41.6,33.5,40.3,33.8,44.8,47,39.5,42.3,36.3,26.5,31,31,37.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P28908-1","tumor necrosis factor receptor superfamily member 8 [OS=Homo sapiens]",4,2,5,2,595,63.7,5.62,6.64,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TNFRSF8","ENSG00000120949","","TNFs bind their physiological receptors","Cytokine-cytokine receptor interaction",0.739,0.765,0.72,0.783,0.754,0.00781235942896497,0.0677150934415212,0.00879128782695847,0.0475756685110632,0.0198797851174957,93.1,96.4,90.7,126,98.7,95,93.6,89.1,92.9,96.2,106.1,91.8,92.2,90.5,89.7,130.7,125.7,118,94.7,98.5,103.1,105.6,94.8,86.7,102.3,97.3,101.4,105.1,115.8,100.3,100.7,98.8,98,142.7,137.3,128.9,103.5,107.5,112.6,115.3,103.5,94.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q92673","Sortilin-related receptor [OS=Homo sapiens]",7,10,14,10,2214,248.3,5.55,23.11,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SORL1","ENSG00000137642","","Amyloid fiber formation","",0.739,0.745,0.748,0.633,0.743,0.000229462837414756,0.00124728355927703,0.000979197745552988,1.60891792998021e-05,0.000535777156083664,96.2,97,97.4,130.2,82.4,96.8,96.5,98.9,88.6,95.7,99.1,97.3,98.4,97.7,97.7,134.5,130.5,121.4,82.4,82.6,86.5,94.5,97,100.7,360.6,369.9,331.2,357.8,370.6,363.6,368.1,365.2,365.1,502.9,488.1,453.7,308.1,309,323.5,353.3,362.8,376.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UJT1","tubulin delta chain [OS=Homo sapiens]",2,1,1,1,453,51,6.83,2.95,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TUBD1","ENSG00000108423","Genes related to primary cilium development (based on CRISPR)","","",0.748,0.825,0.799,0.835,0.801,0.446347556113028,1,0.556904855618559,1,0.363678793798744,89.6,98.8,95.7,119.8,100.1,95.9,86.5,90.4,102.8,99.8,88.4,107.5,96.6,101.1,83.1,121,108.1,129.4,101,109.5,96.7,96.9,78.1,103.1,51.2,53.5,60.8,59,52.3,63.6,57.1,59.8,49.1,71.5,63.9,76.5,59.8,64.7,57.2,57.3,46.2,61,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H2C2","Protein arv1 [OS=Homo sapiens]",7,1,2,1,271,31,8.28,6.68,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","transporter activity","ARV1","ENSG00000173409","","Cholesterol biosynthesis","",0.755,1.121,1.025,0.975,0.965,1,1,1,1,1,77.6,115.2,105.3,102.7,100.1,99.1,63.6,105.5,78,123.2,115.8,98.6,116.4,105.9,86.6,103.3,80.6,116.9,100.7,128,97.3,104.4,99.6,75.8,11.7,19.4,14.3,22.6,21.2,18.1,21.4,19.4,15.9,18.9,14.8,21.4,18.5,23.5,17.9,19.2,18.3,13.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q14332","Frizzled-2 [OS=Homo sapiens]",2,2,2,1,565,63.5,8.1,3.91,"cell-cell signaling;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","FZD2","ENSG00000180340","MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Asymmetric localization of PCP proteins; Ca2+ pathway; Class B/2 (Secretin family receptors); Disassembly of the destruction complex and recruitment of AXIN to the membrane","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",0.76,0.887,0.881,0.769,1.154,1,1,1,1,1,83.6,97.7,96.9,110.1,84.6,127,85.1,73,99.6,106.1,83.8,99.4,98.6,108,82.7,114.1,88.2,112,108.3,84,86.1,129.2,149.5,92.2,61,52.3,71.3,76,60.1,71.2,70.7,77.4,59.2,81.8,63.2,80.2,77.6,60.2,61.7,92.6,107.1,66.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q5T8A7","Protein phosphatase 1 regulatory subunit 26 [OS=Homo sapiens]",1,1,1,1,1209,127.3,8.59,3.09,"other biological processes","nucleus","enzyme regulator activity","PPP1R26","ENSG00000196422","","","",0.769,0.897,0.712,0.796,0.833,1,1,0.650994796222052,1,1,92.2,107.4,85.4,119.8,95.3,99.9,90.2,85.2,98.4,105.1,122.7,98.7,75.9,92,83.5,156,88.1,117.2,93.3,99,86.9,118.9,97.7,91.2,19.6,18.5,21.4,22.8,26.6,21.4,16.5,20,18.1,33.8,19.1,25.4,20.2,21.5,18.8,25.8,21.2,19.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q70Z53","Protein FRA10AC1 [OS=Homo sapiens]",19,5,12,5,315,37.5,8.1,11.96,"other metabolic processes","nucleus","other molecular function","FRA10AC1","ENSG00000148690","","","",0.78,0.862,0.768,0.823,0.868,0.00714726858812686,0.276648611507989,0.0204997414693551,0.0321995496253007,0.108566942519081,91.7,101.4,90.3,117.6,96.8,102.1,91.2,86.5,95.8,104,99.1,100.8,89.5,101.3,89.8,122.6,117,114.9,96.3,92.6,98.6,93.1,101.5,105.4,414.1,392.5,434.9,472,449.9,457.7,406.1,460,407.8,556.3,531,521.4,437.2,420.1,447.4,422.6,460.7,478.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8ND24","Ring finger protein 214 [OS=Homo sapiens]",17,12,17,12,703,77.6,6.95,33.12,"protein metabolism;other metabolic processes","","other molecular function","RNF214","ENSG00000167257","","","",0.782,0.805,0.729,0.77,0.773,0.0133751777712097,0.0833806656358762,0.00540456411643674,0.0086041550999009,0.00846175903313459,96.6,99.4,90,123.4,95.1,95.4,94.6,96.1,97.3,98.9,104.4,97.7,95.9,89.6,88,134.7,114.5,122.9,91.1,96.8,94.7,100.7,87.2,95,690.6,701.9,710.8,722.5,762.4,713.4,700.4,654.1,642.5,983.8,835.8,897.1,664.9,706.7,691.1,735.2,636.5,693.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q4KMQ2-1","Anoctamin-6 [OS=Homo sapiens]",10,5,8,5,910,106.1,7.77,16.54,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","transporter activity;other molecular function","ANO6","ENSG00000177119","","Neutrophil degranulation; Stimuli-sensing channels","",0.79,0.924,0.948,0.83,0.792,0.395000888817617,1,1,0.639580541425,0.0917501320958579,89.6,105,107.6,113.5,94.3,89.9,87.8,105.5,90.2,105.7,106.2,93.1,91.8,108.4,111.2,114.3,120.1,113.8,103.8,94.9,92.3,92.9,77.5,90.5,91.5,109.9,94,110.1,110.7,97,95.6,112.9,115.9,119.1,125.2,118.6,108.1,98.9,96.1,96.7,80.8,94.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q5VUA4","Zinc finger protein 318 [OS=Homo sapiens]",3,6,7,6,2279,251,7.2,14.5,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","ZNF318","ENSG00000171467","Androgen receptor signaling pathway","","",0.797,0.899,0.885,0.836,0.907,0.0974069193188299,1,0.564188276017345,0.0492040278160109,0.572367325555301,89.9,101.3,99.7,112.7,94.2,102.2,89.3,90.3,99.8,101.2,101.9,103.6,100.2,102.3,95,123.1,106.6,113.3,94.7,82.2,94.8,102.7,104.9,94.2,264.8,267.9,296.1,300,302.1,307.2,297.3,303.3,281.6,365,316,336,280.9,243.8,281.2,304.6,311,279.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O00767","acyl-CoA desaturase [OS=Homo sapiens]",11,3,19,3,359,41.5,9,30.34,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","SCD","ENSG00000099194","Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Adipogenesis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; AMPK signaling pathway; Alcoholic liver disease",0.802,0.882,0.79,0.918,0.903,1,1,1,1,1,90.9,99.9,89.5,113.3,104.1,102.4,93.3,93.1,96.2,109.2,99.2,102.6,87.1,92.7,92,116.4,96,118.1,106.9,100,115,105.1,64.8,112.2,792,790.4,816.6,926.8,841.7,870.5,738.9,787.1,780.5,987.5,814.8,1002.5,907,848.9,975.6,892.2,550.2,952.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H611","ATP-dependent DNA helicase PIF1 [OS=Homo sapiens]",5,2,2,2,641,69.8,9.72,2.23,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","mitochondrion;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","PIF1","ENSG00000140451","","Telomere Extension By Telomerase","",0.804,0.876,0.643,0.547,0.607,1,1,0.543074577853284,0.316968249243908,0.541724537052105,107.8,117.4,86.2,134,73.2,81.4,83.7,102.6,105.6,146.2,111.8,107.9,85.6,82.1,81.3,116.6,127.6,141.8,63.4,110.9,69.7,111.1,77.5,74.7,11.6,14.2,14.6,20.3,15.5,15,11.9,11.4,11.3,16.2,17.7,19.7,8.8,15.4,9.7,15.4,10.7,10.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9BZV1","UBX domain-containing protein 6 [OS=Homo sapiens]",18,4,8,4,441,49.7,6.89,16.25,"protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","","UBXN6","ENSG00000167671","","","Protein processing in endoplasmic reticulum",0.812,0.836,0.867,0.862,0.802,0.163484461145073,0.952780645485629,0.803859899807942,0.726793864161613,0.389866512688359,94.1,96.9,100.4,115.8,99.9,92.9,92.5,97,87.2,95.3,95.1,105.7,89.6,98.7,109.3,113.9,115.3,113.4,101.2,98.2,97.5,108.7,91.4,90.1,106.3,111.5,100.2,109.5,109.3,121.5,103,113.4,125.6,130.9,132.6,130.3,116.3,112.9,112.1,125,105,103.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8N9F7","Lysophospholipase D GDPD1 [OS=Homo sapiens]",10,2,3,2,314,36.1,8.47,7.88,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","GDPD1","ENSG00000153982","","Glycerophospholipid catabolism","Ether lipid metabolism; Metabolic pathways",0.817,0.977,0.987,1.156,1.041,1,1,1,1,1,82,98,99.1,100.4,116.1,104.5,80.5,79,101.4,106.5,96.3,93,96.9,97.3,99.8,115.5,98.6,93.9,91.9,114,119.5,100.3,112.9,102.6,58.6,57.5,73.7,77.4,70,67.6,70.5,70.7,72.6,84,71.7,68.3,66.8,82.9,86.9,72.9,82.1,74.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P06454-1","Prothymosin alpha [OS=Homo sapiens]",25,7,48,7,111,12.2,3.78,111.94,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","PTMA","ENSCATG00000024952; ENSCCAG00000025294; ENSG00000187514; ENSGGOG00000009874; ENSMFAG00000031087; ENSMMUG00000012140; ENSMNEG00000029751; ENSNLEG00000014135; ENSRROG00000033267","VEGFA-VEGFR2 signaling pathway","","",0.819,0.971,1.05,1.19,1.124,1,1,1,1,1,79.9,94.7,102.3,97.5,116,109.6,77.2,81.4,74,96,91.5,91.1,121.5,98.4,98.9,129.6,94.2,68.7,146.8,112.1,99.5,110.2,102.9,105.9,1673.8,1765.4,1604.1,2082.9,1984.4,1976.9,2635.5,2134.1,2144.8,2812.1,2043.1,1490.2,3184.1,2432,2159.4,2391.5,2233,2297.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","P18405","3-oxo-5-alpha-steroid 4-dehydrogenase 1 [OS=Homo sapiens]",3,1,2,1,259,29.4,8.94,0,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","SRD5A1","ENSG00000145545","Mammalian disorder of sexual development","Androgen biosynthesis","Steroid hormone biosynthesis; Metabolic pathways",0.824,0.895,1.152,1.021,0.797,1,1,1,1,1,86.9,94.3,121.5,105.5,107.7,84,119.5,86,78,93.4,79.7,101.2,103.3,127.8,120.3,84.3,121.1,104.4,112.8,106.6,91.7,83.2,69.2,117.6,28.4,20.4,18.5,22.2,18.9,24,24.5,30.3,28.6,20,28.7,24.8,26.8,25.3,21.8,19.7,16.4,27.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q7LBC6-1","Lysine-specific demethylase 3B [OS=Homo sapiens]",31,35,82,34,1761,191.5,7.18,158.1,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3B","ENSG00000120733","Thermogenesis","HDMs demethylate histones","Thermogenesis",0.828,0.861,0.822,0.795,0.816,1.37233927036648E-4,0.00107019857401388,6.09825916750829e-05,1.66890069315801e-05,4.6351549879156E-5,97,100.9,96.2,117.1,93.1,95.6,96.6,102.1,95.9,100.6,100.1,100.9,96,95.9,94.9,116.7,115.5,117.2,92.8,91.5,95.9,95.3,98,94.4,2274.7,2402.4,2257.3,2366.9,2355.1,2374.6,2258.9,2257.5,2233,2747.7,2717.7,2758.8,2184.5,2154.3,2256.7,2242.3,2305.9,2221.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96Q45","transmembrane protein 237 [OS=Homo sapiens]",19,6,7,6,408,45.5,6.47,13.49,"cell organization and biogenesis;other biological processes","other membranes;other cell component","","TMEM237","ENSG00000155755","Joubert syndrome; Ciliopathies","","",0.831,1.02,1.04,0.905,0.938,0.811411771551715,1,1,0.986827418315694,1,86.9,106.8,108.8,104.6,94.7,98.1,85.6,83.5,96.4,111.2,98.4,105.2,110.7,107.2,95.1,121.6,98.4,103.1,94.6,81.7,93.3,96.7,123.4,93.8,268.9,262.1,302.6,349.2,308.9,330.1,347.6,336.5,298.5,381.8,309,323.5,297,256.4,292.9,303.4,387.5,294.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q5TCX8","Mitogen-activated protein kinase kinase kinase MLK4 [OS=Homo sapiens]",2,2,2,2,1036,113.9,8.73,5.84,"protein metabolism;other metabolic processes;signal transduction","other cell component","kinase activity;other molecular function","MAP3K21","ENSG00000143674","","","",0.835,0.843,0.893,0.896,0.805,0.565385784464391,0.520511254062454,1,1,0.108951877516656,95,95.9,101.7,113.8,101.9,91.7,94.3,103,95,90.9,95.9,97.8,101.7,102.6,100.5,100.8,124.9,113.8,109.4,101.9,95.8,91.7,83.5,96.5,276.7,302.1,278.7,266.7,281.5,286.9,298.4,301,294.8,295.9,366.6,334,321,299.1,281.2,269,244.9,283.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q96M91","cilia- and flagella-associated protein 53 [OS=Homo sapiens]",2,1,2,1,514,61.8,8.9,4.44,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;other cell component","","CFAP53","ENSG00000172361","Ciliopathies","","",0.838,0.932,0.943,0.886,1.007,1,1,1,1,1,89.7,99.7,100.9,107,94.8,107.8,116.7,79,89.6,99.6,106.8,96,100.8,111.3,83.9,106.9,94.1,107.2,94.7,81.5,108.7,105,110.6,107.6,122,82.7,93.7,104.2,111.6,100.4,105.4,116.3,87.7,111.8,98.4,112.1,99,85.2,113.6,109.8,115.6,112.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q14432","cGMP-inhibited 3',5'-cyclic phosphodiesterase A [OS=Homo sapiens]",2,2,2,1,1141,124.9,6,4.56,"other metabolic processes;signal transduction;other biological processes","other membranes;cytosol","other molecular function","PDE3A","ENSG00000172572","NO/cGMP/PKG mediated neuroprotection; Phosphodiesterases in neuronal function","G alpha (s) signalling events","Purine metabolism; Metabolic pathways; cGMP-PKG signaling pathway; cAMP signaling pathway; Renin secretion; Morphine addiction",0.84,0.948,0.863,0.804,0.899,0.82889914420308,1,1,0.38602506199519,0.970254602519798,94.2,106.2,96.7,112.1,90.1,100.8,87.4,109,93.5,95.7,105.5,107.5,105.8,96,93,118.4,111.3,104.5,87,100.1,89.4,93.2,102.4,100.1,91.4,113.9,97.7,100.1,110.2,112.4,110.6,100.3,97.2,123.8,116.3,109.2,91,104.6,93.5,97.4,107,104.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q15424-1","Scaffold attachment factor B1 [OS=Homo sapiens]",44,45,236,27,915,102.6,5.47,495.93,"cell organization and biogenesis;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SAFB","ENSG00000160633","Interleukin-1 (IL-1) structural pathway","SUMOylation of transcription cofactors","",0.843,0.906,0.887,0.866,0.941,0.0725743644081789,0.896216369758551,0.642202098849792,0.0808386012798904,1,92.9,99.9,97.8,110.2,95.5,103.7,93,92,95.5,96.6,102.4,99.9,103.6,97.8,96.5,114.8,104.2,110.3,95.8,89.8,95.5,103.8,111.5,97,9727.6,9622.8,9991.2,10104.6,10711.5,10453.6,10835.2,10232.1,10099.9,12010,10895.8,11538.5,10026.4,9392.1,9991,10857.2,11668.5,10143,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q6DKI1","60S ribosomal protein L7-like 1 [OS=Homo sapiens]",40,9,19,9,246,28.6,10.51,50.54,"","","","","","","","",0.848,0.865,0.924,0.849,0.717,0.258300361793058,0.575109177079646,1,0.370000371495521,0.00671062045349,97.8,99.7,106.5,115.3,97.9,82.7,92.6,103.5,97.8,97.6,99.8,100.4,96.5,106.6,106.9,104.4,127.3,115.4,98,104.7,95.1,82.6,82.8,87.9,919.1,1026.8,970.7,968.6,989.9,996.6,956.9,1057.8,1060.4,1036.2,1263,1144.9,972.1,1038.3,943.5,820,821.5,872.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P09601","heme oxygenase 1 [OS=Homo sapiens]",14,3,10,3,288,32.8,8.25,26.08,"cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HMOX1","ENSG00000100292","Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Overview of nanoparticle effects; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Lung fibrosis; Oxidative stress response; Ferroptosis; NRF2-ARE regulation; IL-10 anti-inflammatory signaling pathway ; IL-18 signaling pathway; CAMKK2 pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway","Interleukin-4 and Interleukin-13 signaling; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Heme signaling; Cytoprotection by HMOX1; Regulation of HMOX1 expression and activity; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Iron uptake and transport; Heme degradation","Porphyrin metabolism; Metabolic pathways; HIF-1 signaling pathway; Ferroptosis; Mineral absorption; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",0.85,0.882,0.884,0.868,0.937,0.294414026356059,1,0.530912564901554,0.447722601542373,0.733323632304579,94.1,97.6,97.9,110.7,96.1,103.7,91,95.5,97.8,98.3,105.3,99,99.3,90,100.1,112.8,112.3,110,97.4,99.1,92.6,107.7,86.7,105.2,434.1,455.2,466.2,468.8,501.9,472.2,473.3,429,477.2,537.8,535.3,524.7,464.6,472.4,441.5,513.5,413.5,501.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H2Y7","Zinc finger protein 106 [OS=Homo sapiens]",11,18,20,18,1883,208.8,7.15,32.42,"signal transduction","other membranes;cytosol;nucleus","other molecular function","ZNF106","ENSG00000103994","","","",0.851,0.99,0.965,0.835,0.842,1,1,1,1,1,93.2,108.3,105.6,109.4,91.3,92.2,88.6,88.7,93.9,111.3,102.4,103.1,100.5,116.8,96.8,107.6,100.5,104.2,86.9,83.2,98.2,87.8,142.6,87.1,855.3,855.7,905.6,1073.5,988.3,994.6,970.1,1126.6,933.9,1038.6,969.9,1005.1,838.8,802.3,947.1,846.7,1375.8,840.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8TCZ2","CD99 antigen-like protein 2 [OS=Homo sapiens]",8,2,3,2,262,28,5.14,6.32,"cell adhesion","plasma membrane;other membranes","","CD99L2","ENSG00000102181","","Cell surface interactions at the vascular wall","Cell adhesion molecules; Leukocyte transendothelial migration",0.855,0.913,0.869,0.734,0.763,0.906360163819321,1,1,0.439237295534825,0.120209213886055,99.9,106.7,101.5,116.9,85.8,89.2,96.9,98.5,98.5,105.2,108.2,96.3,96.1,109.9,100.1,115.2,108.3,130.4,84.6,113.4,82.5,87.9,76.9,91,155.8,158.4,158.4,169.1,173.9,154.7,154.5,176.6,160.9,185.2,174.1,209.7,136,182.3,132.6,141.4,123.7,146.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q5T8D3-1","Acyl-CoA-binding domain-containing protein 5 [OS=Homo sapiens]",9,4,7,4,534,60.1,5.33,5.14,"other metabolic processes","other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","ACBD5","ENSG00000107897; ENSPPAG00000036984; ENSPTRG00000002380","","Class I peroxisomal membrane protein import; RHOC GTPase cycle; RHOA GTPase cycle; Peroxisomal lipid metabolism","",0.858,0.907,0.808,0.847,0.865,0.336622757109275,1,0.303376123514403,0.461733746680727,0.675918902283627,97.4,103,91.7,113.5,96.2,98.2,98.1,86.8,95.9,117,99.5,101.4,90.3,98.5,86.7,121.1,111.6,111.8,96,94.7,94.2,86.7,112.8,96.6,127,112.3,124.1,151.5,128.9,131.2,116.9,127.5,112.2,156.8,144.5,144.7,124.3,122.6,122,112.3,146.1,125.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y467","sal-like protein 2 [OS=Homo sapiens]",24,14,35,13,1007,105.2,6.3,102.72,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SALL2","ENSG00000165821","","","",0.859,0.881,0.865,0.861,0.898,0.0282081011004947,0.184420191292905,0.116659178398023,0.0346668902547199,0.463809853930963,96.1,98.5,96.8,111.9,96.3,100.4,90.3,95.2,98.1,94.7,97.5,101.8,95.8,101,95.6,117.1,109.7,110.8,95.4,90.9,98.6,99.4,108.7,99.2,1298.5,1368.3,1411,1362.2,1402.7,1464,1377.6,1453,1374.1,1683.9,1577.8,1593,1371.5,1307.6,1418.4,1429.9,1563.6,1426.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q13470-1","Non-receptor tyrosine-protein kinase TNK1 [OS=Homo sapiens]",1,1,1,1,666,72.4,9.48,1.62,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","TNK1","ENSG00000174292; ENSG00000283781","Focal adhesion","","",0.863,0.939,0.877,0.772,0.803,1,1,1,0.645944874141198,0.438591413645596,98.5,107.2,100.1,114.2,88.2,91.7,96.5,80.5,113,94.5,115.4,105,98,117.4,85.7,111.8,111.1,140.8,104.4,86.3,78.5,94,89.8,77,38.9,32.5,45.6,38.1,46.6,42.4,39.6,47.4,34.6,45.1,44.8,56.8,42.1,34.8,31.7,37.9,36.2,31,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9BXB5","Oxysterol-binding protein-related protein 10 [OS=Homo sapiens]",16,10,17,9,764,83.9,8.31,39.02,"other metabolic processes;transport","other membranes;cytosol;cytoskeleton;other cell component","transporter activity;other molecular function","OSBPL10","ENSG00000144645","","Acyl chain remodelling of PS","",0.865,0.903,0.904,0.885,0.88,0.000671923414027798,0.0294067375120176,0.009222655243093,0.00617788768736056,0.00321491186056897,95.5,99.6,99.7,110.4,97.7,97.1,95.9,96.8,92.9,102,97.8,100,95.9,100.2,100.2,110.8,107.6,110.8,96.7,100.8,98.1,97.1,98.5,97.5,563.7,568.8,546,599.7,574.8,587.9,563.8,588.8,588.7,651.4,632.5,651.4,568.5,592.1,576.7,570.6,578.9,572.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O14494","Phospholipid phosphatase 1 [OS=Homo sapiens]",11,2,2,2,284,32.1,7.97,6.23,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","PLPP1","ENSG00000067113","Androgen receptor signaling pathway; Androgen receptor signaling pathway; Sphingolipid pathway; Triacylglyceride synthesis; Androgen receptor signaling pathway","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",0.867,1.033,0.91,1.042,0.745,1,1,1,1,0.814606187352169,92.9,110.8,97.6,107.2,111.7,79.8,90.9,105.6,78,108.3,95.6,108.3,95.1,112.2,95.4,103.2,112,104.8,106.5,109.2,112.1,76.2,78,108.5,101.6,118.1,87.2,121.1,106.9,121.1,106.3,125.5,106.6,115.4,125.2,117.1,119.1,122.1,125.3,85.2,87.2,121.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q659A1-1","Little elongation complex subunit 2 [OS=Homo sapiens]",6,3,3,3,982,109.9,7.09,5.6,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","","ICE2; NARG2","ENSG00000128915","","RNA polymerase II transcribes snRNA genes","",0.869,0.95,0.857,0.92,0.86,0.704892224595094,1,0.530912564901554,1,0.351243102685388,95.6,104.5,94.2,110,101.1,94.6,93.1,94.4,100.6,102.3,103.1,111,90.7,93,96.3,105.5,126.7,108.6,102.4,93.3,99.9,79.7,93.4,106,45.8,46.4,49.5,50.3,50.7,54.6,44.6,45.7,47.4,51.9,62.3,53.4,50.3,45.9,49.1,39.2,45.9,52.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O96028-1","Histone-lysine N-methyltransferase NSD2 [OS=Homo sapiens]",17,19,38,19,1365,152.2,8.69,80.41,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD2","ENSG00000109685","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Lysine degradation; Metabolic pathways; Transcriptional misregulation in cancer",0.872,0.821,0.831,0.817,0.845,0.0288531145707008,6.12422359936472E-3,0.00515779107566427,1.56264765212721E-3,0.016316292599801,100.9,95,96.2,115.7,94.5,97.7,100.8,100.5,100.6,94.4,94.7,96.5,95.9,93.4,97.8,115.4,113.3,118.2,90.9,94.3,95.1,97.4,107,93.9,1597.2,1592.6,1593.9,1495.4,1500.4,1529.1,1519.2,1480.8,1549.1,1828.4,1795.9,1872.4,1440.4,1493.6,1507,1544.1,1695.9,1488.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q6PK18-1","2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 [OS=Homo sapiens]",3,1,1,1,319,35.6,8.18,2.6,"","other membranes","other molecular function","OGFOD3","ENSG00000181396","","","",0.872,0.899,1.009,0.887,0.993,1,1,1,1,1,92.5,95.3,106.9,106,94,105.2,88.2,107.9,76.3,82.7,91,101.1,101,125.3,102,101.1,92.2,111,81.5,89.7,96.4,98.4,153.7,100.4,59.8,73.2,51.7,56.1,61.7,68.5,68.4,84.9,69.2,68.6,62.5,75.3,55.3,60.8,65.4,66.7,104.2,68.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q15771","Ras-related protein Rab-30 [OS=Homo sapiens]",14,2,3,1,203,23,4.97,8.43,"cell organization and biogenesis;signal transduction","other membranes;ER/Golgi;other cell component","other molecular function","RAB30","ENSG00000137502","","Intra-Golgi traffic; RAB geranylgeranylation","",0.874,1.044,1.178,0.903,0.968,1,1,1,1,1,87.9,105,118.4,100.6,90.8,97.3,83.7,103.5,75.7,90,153.9,100,139.2,112.9,105,95.8,83.9,111,79.4,105.9,86.5,80.5,92.7,100.3,14.4,17.8,13.1,15.5,26.5,17.2,24,19.5,18.1,16.5,14.5,19.1,13.7,18.3,14.9,13.9,16,17.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H0W5","Coiled-coil domain-containing protein 8 [OS=Homo sapiens]",16,5,6,5,538,59.3,8.63,10.27,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","CCDC8","ENSG00000169515","","Neddylation","",0.877,0.908,0.865,0.918,0.985,1,1,1,1,1,94.7,98.1,93.5,108.1,99.2,106.4,94.1,87.8,97.3,103.1,93.2,97.5,118.2,76.8,92.8,113,107.3,102.7,98.5,105.5,96,110.1,100.3,105.7,201.2,187.7,208.1,220.5,199.2,208.4,252.8,164.1,198.5,241.5,229.5,219.6,210.6,225.6,205.3,235.5,214.5,226.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O75915","PRA1 family protein 3 [OS=Homo sapiens]",20,3,9,3,188,21.6,9.77,6.29,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","ARL6IP5","ENSG00000144746","","Glutamate Neurotransmitter Release Cycle","",0.878,0.987,0.893,0.877,0.982,1,1,1,1,1,93.8,105.5,95.4,106.8,93.7,104.9,89.4,96.2,92.7,98.7,104.2,107,85.7,116.8,94.3,101.9,105.6,111,83.9,107.4,92.6,103.4,103.7,105.4,93.7,100.9,97.2,103.4,109.3,112.2,89.9,122.5,98.9,106.9,110.7,116.4,87.9,112.6,97.1,108.4,108.7,110.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O15550","Lysine-specific demethylase 6A [OS=Homo sapiens]",8,9,11,9,1401,154.1,7.44,21.8,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6A","ENSG00000147050","Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Malignant pleural mesothelioma","Activation of anterior HOX genes in hindbrain development during early embryogenesis; HDMs demethylate histones","Transcriptional misregulation in cancer",0.88,0.94,0.946,0.891,0.923,0.473307776796981,1,1,0.606849383808023,0.65950398832258,94.6,101.1,101.7,107.5,95.8,99.3,100.3,94,91,99,101.6,100.4,96.8,110.2,101,119.3,100.4,106.8,98.5,94.1,95.2,91,101.6,98.6,259.2,242.9,235.2,255.8,262.6,259.5,250.2,284.8,261,308.3,259.4,276.1,254.5,243.2,245.9,235.1,262.5,254.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q13616","Cullin-1 [OS=Homo sapiens]",40,27,67,27,776,89.6,8,146.07,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","CUL1","ENSG00000055130","Cell cycle; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; Malignant pleural mesothelioma; Notch signaling pathway","Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Iron uptake and transport; Nuclear events stimulated by ALK signaling in cancer; Circadian Clock; Cyclin D associated events in G1; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Wnt signaling pathway; Hedgehog signaling pathway; TGF-beta signaling pathway; Circadian rhythm; Shigellosis; Human immunodeficiency virus 1 infection; Pathways in cancer",0.883,0.927,0.921,0.884,0.821,0.0607334145610517,0.720791055986632,0.318877032040647,0.0946964977170124,2.27089543315139E-3,97.5,102.3,101.7,110.4,97.6,90.6,95.4,97.9,99.2,103.3,102.8,100.8,102.1,96.5,103.8,105.5,117.1,110.9,98,101.7,95.7,91,86.1,92.2,2885.2,2960.6,3000.8,3123.5,3108.6,3048.1,3088.6,2917.3,3137.1,3191.5,3539.4,3352.5,2963.6,3075.7,2893,2753,2602.1,2786.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P98174","FYVE, RhoGEF and PH domain-containing protein 1 [OS=Homo sapiens]",3,2,2,2,961,106.5,6.58,4.88,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","FGD1","ENSG00000102302","Regulation of actin cytoskeleton","G alpha (12/13) signalling events; CDC42 GTPase cycle; NRAGE signals death through JNK","Regulation of actin cytoskeleton",0.883,1,0.911,0.821,0.919,1,1,1,1,1,95.7,108.4,98.8,108.4,89,99.7,77.7,93.2,100.9,111,105.6,103.3,105.2,93.5,96.2,123.1,100.8,105.5,78.6,115.9,86.6,110.1,95.7,97,95.9,115,124.5,136.9,130.2,127.5,129.9,115.3,118.7,151.9,124.4,130.2,97,143,106.8,135.8,118.1,119.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UDY2","Tight junction protein ZO-2 [OS=Homo sapiens]",33,31,97,1,1190,133.9,7.4,182.97,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","TJP2","ENSG00000119139","1q21.1 copy number variation syndrome","Signaling by Hippo; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Apoptotic cleavage of cell adhesion  proteins","Tight junction; Vibrio cholerae infection",0.886,0.881,0.83,0.823,0.829,0.0570079733848396,0.117256882231007,0.00891277803458027,0.00315400557630397,2.24847794314675E-3,101.3,100.7,94.9,114.3,94.1,94.8,102.4,103.6,97,99.6,102.1,101.8,95.9,95.8,96.4,117.1,109.6,115.5,97.2,90.3,95.1,96.1,88.8,95.8,4152.6,4201.7,3933.4,4041,4141.6,4128,3891.5,3886.6,3909.3,4749.9,4445.8,4686,3943.4,3664.8,3856.8,3897.8,3603.7,3885.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NZM3","Intersectin-2 [OS=Homo sapiens]",3,5,7,4,1697,193.3,8.12,14.25,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ITSN2","ENSG00000198399","","Cargo recognition for clathrin-mediated endocytosis; RHOU GTPase cycle","",0.887,0.928,0.854,0.842,0.808,1,1,1,0.290111306868445,0.252457050244469,100,104.6,96.4,112.8,95,91.1,106.9,95.7,100.4,99.7,105,110.7,96.7,95.9,101,113.6,103.9,113.2,96,95.4,87.1,91.5,84.1,103.3,344.4,308.3,323.6,321.4,338.4,356.7,311.6,309,325.5,366.1,334.8,364.8,309.5,307.3,280.6,294.8,271.1,332.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P49441","Inositol polyphosphate 1-phosphatase [OS=Homo sapiens]",14,3,4,3,399,44,5.26,7.09,"other metabolic processes;signal transduction","cytosol","other molecular function","INPP1","ENSG00000151689","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",0.889,1.112,0.937,0.987,0.883,1,1,1,1,1,91.8,114.9,96.8,103.3,102,91.2,90.5,105.1,91.4,90.8,114.4,122.4,91.9,96.4,104,96,108.4,102.8,101.5,115.1,93.3,99.7,90.8,85.5,30.1,34.9,30.4,30.2,38.1,40.7,30.6,32.1,34.6,31.9,36.1,34.2,33.8,38.3,31,33.2,30.2,28.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96SY0","Integrator complex subunit 14 [OS=Homo sapiens]",29,10,28,10,518,57.4,5.12,64.8,"RNA metabolism OR transcription;other metabolic processes","nucleus","","INTS14","ENSG00000138614","","RNA polymerase II transcribes snRNA genes","",0.891,0.96,0.894,0.885,0.851,0.596121068556734,1,1,0.503147330186197,0.120209213886055,97.5,105.1,97.8,109.5,96.9,93.1,97.8,97.7,95.5,102.8,105.3,106.4,98,96.5,108.7,107.2,110.2,109.7,97.4,97.1,94.3,100.7,81.6,93.3,1136.8,1135.9,1110.3,1194.9,1223.7,1237.5,1139.4,1122.1,1263.2,1246,1281.5,1275,1132,1128.6,1095.9,1170.2,948.1,1084.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96T21","selenocysteine insertion sequence-binding protein 2 [OS=Homo sapiens]",13,7,9,7,854,95.4,8.12,24.57,"protein metabolism;other metabolic processes;developmental processes;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","SECISBP2","ENSG00000187742","","Selenocysteine synthesis","",0.892,0.887,0.87,0.9,0.831,0.444041350174802,0.943518245999601,0.194062109088187,0.416736889430377,0.0619585388734159,99.5,98.9,97,111.5,100.4,92.6,96,99.1,102.5,98.1,105.8,98.5,100.4,88.7,96.6,125.4,105.2,111.1,100,93.4,103.3,92.3,89.5,94.2,373.3,385.5,398.4,381.4,411.3,383,390.6,344.9,375.8,487.6,408.9,432,388.9,363.1,401.9,358.8,348,366.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P46020-1","Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [OS=Homo sapiens]",7,8,12,7,1223,137.2,6.19,26.24,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","PHKA1","ENSG00000067177","Glycogen synthesis and degradation","Glycogen breakdown (glycogenolysis)","Calcium signaling pathway; Insulin signaling pathway; Glucagon signaling pathway",0.893,0.911,0.91,0.906,0.876,1,1,1,1,0.476410909042501,97.5,99.4,99.3,109.2,98.9,95.7,97.5,98.6,102.3,100.6,96.3,108,100.5,102.5,97.7,98.2,110.7,110.5,94.8,101.5,100,96.8,83.8,99.8,592.5,599.1,621.5,610.9,584.9,655.7,610.2,622.3,593.4,596.7,672.1,670.9,575.8,616.4,607.5,587.9,508.9,606.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UHK0","Nuclear fragile X mental retardation-interacting protein 1 [OS=Homo sapiens]",4,2,3,2,495,56.3,9.13,2.54,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NUFIP1","ENSG00000083635","","","",0.896,0.989,0.985,0.977,0.924,1,1,1,1,1,93.1,102.8,102.4,104,101.5,96.1,105.6,83.4,91.8,101.4,104,101.3,84.7,115.4,101,116.2,92,102.5,96.9,100.1,119.6,96.4,93.2,94.7,110.2,87,95.8,105.8,108.5,105.7,88.4,120.4,105.4,121.3,96,107,101.1,104.5,124.8,100.6,97.3,98.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H4M3-2","Isoform 2 of F-box only protein 44 [OS=Homo sapiens]",13,2,2,2,224,25.7,7.88,5.88,"","","","FBXO44","","","","",0.898,0.998,0.877,1.01,0.844,1,1,1,1,1,95.7,106.4,93.5,106.6,107.7,90,132.5,93.3,93.8,122.8,93.5,104.3,107.3,87.2,91.6,104.6,86.2,104.4,83.6,110.4,105.5,84.4,88.2,106.3,70,49.3,49.5,64.9,49.4,55.1,56.7,46.1,48.4,55.3,45.5,55.2,44.1,58.3,55.7,44.6,46.6,56.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O15066","Kinesin-like protein KIF3B [OS=Homo sapiens]",12,9,10,6,747,85.1,7.69,24.97,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3B","ENSG00000101350","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",0.899,0.922,0.863,0.879,0.951,0.933169456927733,1,0.526414689215082,0.199292787637726,1,97.8,100.3,93.9,108.8,95.7,103.5,98.7,96.5,100.5,96.6,101.2,104.1,94.8,97.3,94.1,104.8,109.9,111.8,99.9,82,96.6,104.5,108.8,98.1,544.2,531.8,553.9,532.4,558,573.5,522.4,536.3,518.4,577.9,605.5,615.9,550.5,451.9,532.2,575.8,599.5,540.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NW75-1","G patch domain-containing protein 2 [OS=Homo sapiens]",18,7,12,7,528,58.9,9.09,19.31,"other biological processes","nucleus","nucleic acid binding activity","GPATCH2","ENSG00000092978","","","",0.901,0.982,0.918,0.935,0.923,0.430906749672134,1,0.446659880778516,1,0.530745709163304,95.5,104.1,97.3,106,99.1,97.9,95.3,97.1,93.4,103.9,110.4,103.7,86,97.1,101.6,113.5,104.5,105.8,96.3,98.9,103,101,90.8,97.7,366.2,373,358.8,399.1,424.2,398.3,330.6,373.1,390.4,436,401.3,406.6,370,380.1,395.6,388,348.9,375.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P46937-1","Transcriptional coactivator YAP1 [OS=Homo sapiens]",8,2,3,2,504,54.4,5.17,8.01,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","YAP1","ENSG00000137693","Mesodermal commitment pathway; Mesodermal commitment pathway; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; miR-509-3p alteration of YAP1/ECM axis; Ciliary landscape; Leukocyte-intrinsic Hippo pathway functions; Netrin-UNC5B signaling pathway; Galanin receptor pathway; Malignant pleural mesothelioma","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Nuclear signaling by ERBB4; Signaling by Hippo; EGR2 and SOX10-mediated initiation of Schwann cell myelination; RUNX2 regulates osteoblast differentiation; YAP1- and WWTR1 (TAZ)-stimulated gene expression; RUNX3 regulates YAP1-mediated transcription","Hippo signaling pathway; Hippo signaling pathway",0.902,1.125,1.074,1.15,1.032,1,1,1,1,1,86.2,107.4,102.5,95.5,109.8,98.6,108.4,89,60.8,121.2,111,81.9,106,113.2,84.5,98.7,82.5,114.2,113.5,70.2,133.9,94.8,114.5,101.8,15.1,12.4,8.4,16.8,15.4,11.4,14.7,15.7,11.7,13.7,11.5,15.8,15.8,9.7,18.6,13.2,15.9,14.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q7Z2E3-1","Aprataxin [OS=Homo sapiens]",16,5,7,5,356,40.7,9.17,14.55,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","APTX","ENSG00000137074","","","",0.903,0.943,0.939,0.944,0.895,1,1,1,1,1,96.3,100.6,100.1,106.7,100.7,95.5,106.5,95.6,96.8,104.6,101.1,93.3,100.7,96.8,104.9,107.2,91.8,109.6,103.8,101.2,94.9,96,94.6,100.5,260,233.4,236.4,255.5,246.9,227.9,245.8,236.3,256.2,261.8,224.2,267.5,253.4,247.2,231.7,234.5,230.9,245.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P61599","N-alpha-acetyltransferase 20 [OS=Homo sapiens]",23,3,6,3,178,20.4,5.03,10.76,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NAA20","ENSG00000173418","Metapathway biotransformation Phase I and II","","",0.904,0.943,0.973,1.052,0.977,1,1,1,1,1,92.8,96.8,99.8,102.6,107.9,100.2,91.9,106.9,75.5,101.7,91.3,95.9,98.9,113,89.6,96.1,113.6,101.7,117.7,106.9,95.9,99.3,95.9,108.2,65.4,76,53.7,72.3,64.9,68.2,70.3,80.4,63.7,68.3,80.8,72.3,83.7,76,68.2,70.6,68.2,77,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8IV48","3'-5' exoribonuclease 1 [OS=Homo sapiens]",9,3,6,3,349,40,6.7,9.04,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","translation activity;nucleic acid binding activity;other molecular function","ERI1","ENSG00000104626","exRNA mechanism of action and biogenesis","Major pathway of rRNA processing in the nucleolus and cytosol","",0.906,0.935,0.964,0.977,0.97,0.235325268287034,0.943273413949943,1,1,1,94.5,97.5,100.5,104.3,101.9,101.2,92.7,95.7,94.9,100.1,97.9,93.5,108.1,100.3,100.9,108.9,104.7,103.6,103,91.2,102.2,101.6,102.6,98.1,306.1,316,313.3,330.6,323.2,308.8,357.1,331.3,333.1,359.6,345.7,342.1,340.1,301.2,337.6,335.4,338.7,323.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96AQ6","Pre-B-cell leukemia transcription factor-interacting protein 1 [OS=Homo sapiens]",25,13,28,13,731,80.6,5.33,44.16,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PBXIP1","ENSG00000163346","VEGFA-VEGFR2 signaling pathway","","",0.907,0.947,0.945,0.881,0.906,0.932267191738455,1,1,0.258228595113343,0.702051767588096,97.4,101.7,101.5,107.4,94.6,97.3,101.1,96.7,96.4,97.6,101,106.9,108.3,100.8,96.6,113.5,101.7,106.6,94,87.3,99.1,95.5,100.3,96.6,841.8,805.2,802.6,812.4,841.2,890.1,902.2,839.1,804.8,945.3,846.8,887.9,782.3,727.1,825.4,794.9,834.9,804.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96EY9","probable inactive tRNA-specific adenosine deaminase-like protein 3 [OS=Homo sapiens]",7,2,2,2,351,38,7.88,2.15,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","ADAT3","","","tRNA modification in the nucleus and cytosol","",0.908,1.009,0.947,1.058,1.028,1,1,1,1,1,91.6,101.7,95.5,100.8,106.7,103.7,110.6,87.8,89.3,93.9,99.2,105,93.1,101,87.6,123.1,91.9,98.3,108.1,95.1,104.1,89.4,121.5,101.1,83.4,66.2,67.4,70.8,74.8,79.2,70.2,76.2,66.1,92.9,69.3,74.1,81.5,71.7,78.5,67.4,91.6,76.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O94760-1","N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [OS=Homo sapiens]",29,7,24,6,285,31.1,5.81,61.15,"other metabolic processes;signal transduction;other biological processes","cytosol","other molecular function","DDAH1","ENSG00000153904; ENSMFAG00000037521; ENSMMUG00000014573; ENSMNEG00000044101; ENSRBIG00000034663; ENSRROG00000009892","Mesodermal commitment pathway; Nitric oxide metabolism in cystic fibrosis","eNOS activation","",0.91,1.021,0.957,0.983,0.968,0.249994960017067,1,1,1,1,93.5,104.9,98.4,102.8,101,99.4,97.9,91.8,93.3,104.5,104.7,106.8,98.1,104.5,96.3,103.3,99.5,102.5,102,99.3,100.7,100.1,95.5,99.2,881.3,826.6,840.1,941.3,942.5,962.2,883.3,941.2,867.1,930.2,896.2,923,918.4,894.5,906.9,901.8,860.2,893.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y6H1","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 [OS=Homo sapiens]",34,3,6,3,151,15.5,9.22,12.94,"cell organization and biogenesis;stress response;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","CHCHD2","ENSG00000106153","","Mitochondrial protein import","",0.911,0.917,0.887,1,0.908,0.986512342839669,1,0.795750950946087,1,0.504463453495627,97.3,97.8,94.7,106.7,106.7,96.8,101.4,93.7,97.1,107.2,97.7,88.5,94.6,98.7,92.2,121.5,104.2,106.6,106.6,109.5,97.7,85.5,96.7,100.8,204.4,189,195.9,216.3,197,178.4,190.7,199,186,244.9,210,214.9,214.9,220.8,197,172.4,195,203.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","A5PLN9-1","Trafficking protein particle complex subunit 13 [OS=Homo sapiens]",16,4,6,4,417,46.5,5.6,10.22,"","cytosol;ER/Golgi","","C5orf44; TRAPPC13","ENSG00000113597","","RAB GEFs exchange GTP for GDP on RABs","",0.912,0.974,0.992,0.903,0.81,1,1,1,1,0.464087353737616,97.9,104.5,106.4,107.3,96.9,86.9,94.5,109.7,97.7,107.4,104.4,102.2,106.3,89.7,114.7,107.2,111.4,100.3,103.5,92.6,96.8,98.5,76.4,86.8,128.6,149.3,133.1,146.2,142.2,139.1,144.7,122.1,156.1,145.9,151.6,136.6,140.9,126,131.8,134.1,104.1,118.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9C0I1","Myotubularin-related protein 12 [OS=Homo sapiens]",14,8,14,8,747,86.1,6.62,25.34,"other metabolic processes;transport","cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","MTMR12","ENSG00000150712","","Synthesis of PIPs at the early endosome membrane","",0.914,0.913,0.857,0.877,0.865,0.0928360611901932,0.6892884449923,0.0172348151997012,0.0251047618086116,6.53240008206055E-3,101,101,94.7,110.6,97,95.7,101.6,95.5,102,100.8,106,101.6,96.8,95.1,95.3,111.2,107.2,112.5,99.5,97.6,94.1,96.5,90.4,96.3,607.9,571.3,609.8,602.9,634.3,607.8,579,568.7,570.1,665.4,641.5,673.1,595,583.7,562.6,577.1,540.6,575.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q12874","splicing factor 3a subunit 3 [OS=Homo sapiens]",39,21,100,21,501,58.8,5.38,245.79,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","SF3A3","ENSG00000183431","Exercise-induced circadian regulation; mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",0.915,0.956,0.923,0.937,0.953,0.224911409388632,1,0.681689526755154,0.253537469316674,1,96.6,100.9,97.4,105.5,98.9,100.6,96.4,95.2,96.6,97.6,102.4,100.7,97.2,102.6,95.8,110.4,105.3,105.3,98.7,90.7,99.6,100.4,107.7,97.3,4793.7,4734.2,4804.9,4855.2,5089.5,5007.2,4834,5103.2,4764,5489.3,5237.3,5235,4909.8,4507.8,4951.9,4991.4,5353.1,4840.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NXE8","pre-mRNA-splicing factor CWC25 homolog [OS=Homo sapiens]",9,4,8,4,425,49.6,10.18,15.82,"RNA metabolism OR transcription;other metabolic processes","nucleus","","CWC25","ENSG00000273559; ENSG00000276761","","mRNA Splicing - Major Pathway","",0.916,0.954,0.987,0.966,0.942,0.509215919132301,1,1,1,1,95.3,99.3,102.7,104.1,100.6,98,87.9,98.2,95.6,93.8,99.6,100.1,92.8,105.4,103.1,104.4,100.8,113.3,100.2,101.8,100.9,107.4,98.3,96.4,402.7,449.7,438,429.6,456.3,458.6,424.9,482.9,472.1,478.2,461.5,519,459,466.3,462,492.2,450.4,441.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96SI1-1","BTB/POZ domain-containing protein KCTD15 [OS=Homo sapiens]",29,5,7,5,283,31.9,7.44,10.1,"cell organization and biogenesis","","other molecular function","KCTD15","ENSCANG00000029674; ENSG00000153885","","Negative regulation of activity of TFAP2 (AP-2) family transcription factors","",0.918,0.887,0.896,0.927,0.915,1,1,0.989029108380202,1,1,99.4,96,97,108.3,100.3,99.1,99.8,94.9,105.8,96.4,103.3,93.9,103.8,91.5,97.3,108.7,109.3,103.4,101.7,92.3,100.7,102.4,95.3,99.5,294.8,280.1,312.5,284.6,304.9,277.4,306.5,270.1,287.5,321,322.9,305.4,300.3,272.7,297.5,302.5,281.4,293.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O95777","U6 snRNA-associated Sm-like protein LSm8 [OS=Homo sapiens]",52,3,17,3,96,10.4,4.48,40.09,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","LSM8","ENSG00000128534","","mRNA Splicing - Major Pathway","RNA degradation; Spliceosome",0.92,1.04,0.96,0.935,0.832,1,1,1,1,0.392085396772925,97,109.7,101.3,105.5,98.6,87.8,100.4,95.3,97,110.7,104.3,109.8,93.7,101.3,108,105.5,115.8,105,105.9,98.6,87.8,87.8,70.7,102.3,282.8,268.2,273.3,311.7,293.8,309.1,263.9,285.3,304.2,297.2,326,295.6,298.3,277.8,247.3,247.4,199.1,288.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","A5YKK6","CCR4-NOT transcription complex subunit 1 [OS=Homo sapiens]",22,46,128,46,2376,266.8,7.11,215.71,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","CNOT1","ENSG00000125107","Ciliary landscape","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",0.92,0.935,0.894,0.91,0.902,1,1,1,1,0.296696574382691,99.3,100.9,96.5,107.9,98.2,97.3,99.8,101.5,96.3,99.7,102.4,101.4,96.9,95,103.6,103.9,108.6,108.4,98.6,101.5,98.6,97.8,84.5,101.3,4331.9,4408,4181.2,4328.8,4445.3,4402.6,4208.3,4125.7,4499.4,4511.5,4713.7,4706.3,4282.7,4405.5,4282.6,4246.4,3668.8,4399.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9P2R6","Arginine-glutamic acid dipeptide repeats protein [OS=Homo sapiens]",2,3,4,3,1566,172.3,7.69,9.41,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RERE","ENSG00000142599","","","",0.922,0.968,0.983,0.943,0.922,1,1,1,1,1,96.4,101.3,102.7,104.5,98.6,96.4,94.4,95.2,97.8,111.2,100,99.7,108.7,101.5,79.3,103.5,93.8,103.3,97.4,76,103.4,95.3,155.1,84.4,358.7,361.7,371.4,422.3,379.9,378.6,412.8,385.5,301.1,393,356.1,392.3,370,288.6,392.8,361.9,589,320.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q6I9Y2","THO complex subunit 7 homolog [OS=Homo sapiens]",19,3,3,3,204,23.7,5.67,5.61,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","THOC7","ENSG00000163634","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Nucleocytoplasmic transport",0.924,0.977,1.007,1.008,0.854,1,1,1,1,0.703641780259985,96.1,101.6,104.7,104,104.8,88.8,96.5,92.1,117.9,102,111.1,96.6,110.4,105.2,96.3,108.8,104.4,96.1,115,105.2,89,73,89.2,91.3,168.9,161.3,206.5,178.6,194.5,169.1,193.3,184.2,168.6,190.5,182.9,168.2,201.5,184.3,155.8,127.9,156.2,159.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q5HYK7","SH3 domain-containing protein 19 [OS=Homo sapiens]",8,5,6,5,790,86.5,8.32,4.55,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","SH3D19","ENSG00000109686","","Golgi Associated Vesicle Biogenesis","",0.925,0.883,0.889,0.867,0.863,0.950659886757709,0.759492046218093,0.846495701301197,0.13891255858259,0.0608294932592117,102.2,97.6,98.3,110.6,95.9,95.4,98.9,103.5,102.8,101.1,98.1,98.1,98.8,97.9,105,106.2,111.2,116.4,96.4,97.1,91,98.6,83.1,95.9,118.1,123.6,122.8,120.8,117.2,117.2,118,116.9,125.5,126.8,132.8,139.1,115.1,116,108.7,117.8,99.3,114.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O95292","Vesicle-associated membrane protein-associated protein B/C [OS=Homo sapiens]",48,11,35,10,243,27.2,7.3,61.69,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAPB","ENSG00000124164","Ciliary landscape","RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle; Sphingolipid de novo biosynthesis","Cholesterol metabolism; Amyotrophic lateral sclerosis; Pathways of neurodegeneration",0.926,0.96,1.008,0.894,0.901,1,1,1,1,1,97.7,101.2,106.3,105.5,94.3,95,82.9,99,98.2,109.1,101.7,100,106.8,108.7,102.3,109.8,106,98.5,92.4,94.8,101.2,86.9,106,95.5,1592.1,1901.2,1884.9,2093.9,1953.5,1919,2051.5,2087.6,1964.4,2107.3,2035.8,1891.1,1774.7,1820.1,1942.7,1669.3,2036.1,1834.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8IWA4-1","Mitofusin-1 [OS=Homo sapiens]",20,13,24,13,741,84,6.25,37.8,"","","","","","","","",0.928,0.94,0.974,0.926,0.88,1,1,1,1,0.661741907180736,98.6,99.8,103.5,106.2,98.4,93.4,104,98.5,100.6,98,104.2,101.9,105.7,95.6,107.3,96.6,109.3,108.5,100.5,101.4,92.2,95.4,80.8,99.7,554.3,525.1,536.6,522.5,555.3,543.5,563.5,509.5,572.2,514.8,582.7,578.4,535.8,540.5,491.6,508.7,430.8,531.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NUE0","Palmitoyltransferase ZDHHC18 [OS=Homo sapiens]",3,1,1,1,388,42,9.04,2.7,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ZDHHC18","ENSG00000204160","","","",0.928,0.994,0.996,1.089,1.01,1,1,1,1,1,92.6,99.1,99.3,99.7,108.6,100.7,93.4,90.2,108.8,99.9,98,104.4,100.2,101.7,91.6,105.9,100.6,94.4,93.7,114.6,109.5,101.6,104.6,87.1,76,73.4,88.5,81.3,79.8,84.9,81.5,82.8,74.5,86.2,81.9,76.8,76.2,93.3,89.1,82.7,85.1,70.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96GZ6-9","Isoform 9 of Solute carrier family 41 member 3 [OS=Homo sapiens]",7,2,4,2,487,52.4,6.92,10.24,"","","","SLC41A3","","","","",0.93,1.179,1.104,1.229,1.006,1,1,1,1,1,86.5,109.7,102.8,93,114.4,93.6,94.6,86.6,79.7,82.7,109.8,115.1,106.3,86.2,102.9,93.2,91.8,117,128.8,114.6,102.2,93.7,65.3,129.3,21.3,19.5,17.9,18.6,24.7,25.9,23.9,19.4,23.2,21,20.7,26.3,29,25.8,23,21.1,14.7,29.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P06730","Eukaryotic translation initiation factor 4E [OS=Homo sapiens]",35,8,61,8,217,25.1,6.15,130.25,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","EIF4E","ENSG00000151247","Translation factors; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Hypertrophy model; Interferon type I signaling pathways","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; mTORC1-mediated signalling","EGFR tyrosine kinase inhibitor resistance; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Longevity regulating pathway; Insulin signaling pathway",0.932,0.992,0.973,1.007,0.935,0.868405418733512,1,1,1,0.866734090762533,95.7,101.9,100,102.7,103.5,96.1,95.1,93.2,101.1,105.9,101.3,99.6,95.5,103.3,99.4,102.8,101.4,102.1,104.1,101.7,102.9,95.5,95.2,100,3056.4,2995.5,3250,3403,3255.5,3200.9,3068.2,3318.4,3193.9,3302.7,3257.6,3281.1,3344.1,3267.5,3305.1,3068.1,3059.7,3213.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q01860","POU domain, class 5, transcription factor 1 [OS=Homo sapiens]",28,9,37,8,360,38.5,5.94,74.04,"cell-cell signaling;stress response;developmental processes;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","POU5F1","ENSG00000204531; ENSG00000206454; ENSG00000229094; ENSG00000230336; ENSG00000233911; ENSG00000235068; ENSG00000237582","Cardiac progenitor differentiation; Endoderm differentiation; Mesodermal commitment pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; let-7 inhibition of ES cell reprogramming; Pre-implantation embryo; Wnt signaling pathway and pluripotency; CCL18 signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways","POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation","Signaling pathways regulating pluripotency of stem cells",0.933,0.876,0.815,0.875,0.801,1,1,0.19483002857984,0.500987958643684,0.0237193494266489,105.6,99.1,92.3,113.2,99.1,90.7,110.2,106.5,104,100,103.1,99.9,94.9,93.1,92.5,114.2,116.4,109.1,101,99.9,93.8,91.5,74.6,95.4,2306.8,2230.3,2177.2,2093.9,2160.2,2092.1,1988.3,1948.7,1937.9,2391.2,2436.9,2285,2115.1,2093.1,1964.4,1915.9,1561.8,1997.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q93009","Ubiquitin carboxyl-terminal hydrolase 7 [OS=Homo sapiens]",54,46,138,46,1102,128.2,5.55,305.28,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","USP7","ENSG00000187555","Nucleotide excision repair in xeroderma pigmentosum","Ub-specific processing proteases; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of TP53 Degradation; Formation of TC-NER Pre-Incision Complex; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of PTEN localization","FoxO signaling pathway; Epstein-Barr virus infection; Viral carcinogenesis",0.933,0.97,0.955,0.962,0.905,1,1,1,1,0.393180311757837,97.8,101.7,100.1,104.8,100.8,94.9,97.5,102.4,98.6,98.7,102.9,102.5,100.9,93.8,103.4,101.1,108.7,105.6,101.3,104.3,101.6,95.6,81.1,100,4664.1,4898.6,4714.1,4721.2,4919.5,4900.8,4824.1,4484.1,4942.5,4832.7,5198.8,5052.3,4844.9,4987.7,4860.5,4573.3,3878,4783.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H9T3","elongator complex protein 3 [OS=Homo sapiens]",28,15,31,15,547,62.2,8.88,55.66,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","ELP3","ENSG00000134014","Ethanol effects on histone modifications","HATs acetylate histones","",0.935,0.997,0.959,0.974,0.925,0.117210982174359,1,0.469141077973137,1,0.104063711231788,96.9,103.3,99.4,103.6,101,95.8,96.1,99.4,96.5,103.1,102.9,102.3,97.6,99.6,99.1,103.3,104.4,102.4,101.5,99.6,100.6,95.5,94.9,101.2,1080.5,1117.1,1085.3,1158.4,1157,1149.5,1097.1,1120,1113.5,1160.9,1173.8,1150.7,1140.9,1119.5,1131,1073.5,1067.3,1138,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P08559","Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [OS=Homo sapiens]",56,20,118,20,390,43.3,8.06,270.27,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","PDHA1","ENSG00000131828","TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Lipid metabolism pathway; PI3K/AKT/mTOR - VitD3 signaling; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Acetylcholine synthesis; Glycolysis and gluconeogenesis","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Glycolysis / Gluconeogenesis; Citrate cycle (TCA cycle); Pyruvate metabolism; Metabolic pathways; Carbon metabolism; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer; Diabetic cardiomyopathy",0.936,0.976,0.984,0.939,0.976,0.0914175806148643,1,1,0.0475756685110632,0.747455594949113,96.7,100.8,101.6,103.2,96.9,100.8,96.7,95.3,98.8,100.8,100,102.3,101.6,104.5,100.9,102.9,103.3,104.8,97,94.1,97.1,102.6,96.6,100.8,3175.4,3128.4,3243.5,3309.1,3282.1,3359,3337,3430.3,3313.9,3377.7,3391,3441.8,3184,3090.2,3187.5,3367.7,3170.1,3309.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96BW9-1","Phosphatidate cytidylyltransferase, mitochondrial [OS=Homo sapiens]",16,6,11,6,452,51,7.94,31.51,"other metabolic processes","other membranes;mitochondrion","other molecular function","TAMM41","ENSG00000144559","","","",0.937,0.94,0.932,0.893,0.964,1,1,1,1,1,99.2,99.5,98.7,105.9,94.6,102.1,99.8,102.8,98.8,100.7,100.1,98.1,96.9,103.8,99.2,97.7,106.8,106.5,95.1,106.6,89,102.7,90.3,105.1,447.6,461.1,443.2,452,448.8,440.1,434.9,465.6,445,438.2,479.3,477.7,426.7,478.2,399.2,460.6,405.2,471.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O95071","E3 ubiquitin-protein ligase UBR5 [OS=Homo sapiens]",18,35,63,35,2799,309.2,5.85,149.28,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBR5","ENSG00000104517","Mesodermal commitment pathway","","Ubiquitin mediated proteolysis",0.938,0.949,0.923,0.935,0.914,0.92889747305415,1,0.901486850802203,0.789694966230885,0.0854611196752991,99.5,100.6,97.8,106,99.1,96.9,99.7,100.3,99.8,99.7,101,101.3,98.2,96.8,103.4,102.8,106.6,106.4,99,99.8,99.5,99,89.3,97.3,2187.6,2200.6,2191.3,2187.8,2215.8,2224.1,2155,2125.4,2270.5,2257.1,2340.5,2335.7,2172,2190.6,2183.9,2173.7,1960.7,2135.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y316-1","Protein MEMO1 [OS=Homo sapiens]",21,5,11,5,297,33.7,7.14,22.28,"other biological processes","","other molecular function","LOC111154137; LOC114499315; MEMO1","ENSANAG00000021250; ENSCANG00000020056; ENSCATG00000030724; ENSCCAG00000037443; ENSCHIG00000006439; ENSCJAG00000003208; ENSDLEG00000015222; ENSECAG00000019946; ENSFCAG00000001385; ENSG00000162959; ENSHGLG00000018935; ENSMMUG00000003908; ENSMNEG00000040106; ENSMODG00000047380; ENSPANG00000022798; ENSPCOG00000018130; ENSPCTG00005009736; ENSPTRG00000050445; ENSRFEG00010015180; ENSSSCG00000008515; ENSSSCG00070008027; ENSVURG00010020209; ENSVVUG00000007616","","ERBB2 Regulates Cell Motility; ERBB2 Regulates Cell Motility","",0.939,0.967,0.905,0.961,0.914,0.950561388050793,1,0.71251287176941,1,0.35218075375127,99.1,102.1,95.5,105.5,101.4,96.4,99.8,99.8,95.2,103.4,101.5,102.8,94.8,99.8,96.2,109.7,99.5,106.3,103,102.2,98.8,100.6,89.4,97.2,535,535.1,510.4,554.1,544.3,551.3,508.2,534.8,515.6,587.9,533.6,570,552.1,547.8,529.8,539.3,479.5,520.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q16795","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [OS=Homo sapiens]",27,8,21,8,377,42.5,9.8,32.86,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFA9","ENSG00000139180","Electron transport chain: OXPHOS system in mitochondria; Ciliary landscape; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",0.94,0.958,0.958,0.925,0.897,1,1,1,1,0.325864495103163,99.4,101.2,101.3,105.7,97.8,94.8,99,102.9,97.9,103.8,100.3,100.8,100.8,100.9,107,98.1,114.6,105.3,97.4,101.9,92.3,94.4,84.8,97.9,558.6,580.3,552.3,585.4,565.7,568.8,568.5,569.2,603.7,553.2,646.6,594,549.5,574.8,520.5,532.6,478.7,552.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q7L8W6","Diphthine--ammonia ligase [OS=Homo sapiens]",23,6,14,6,267,30.3,5.4,17.11,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","DPH6","ENSG00000134146","","Synthesis of diphthamide-EEF2","",0.941,1,0.974,1,0.983,1,1,1,1,1,95.8,101.7,99.1,101.7,101.7,100,94.2,96.4,98.5,102.6,96.7,102.4,94.8,99.8,101.2,102.4,113.2,99.2,96.1,104.6,102.4,100.7,87,107.7,259.5,265.7,271.4,282.7,266.5,282.2,261.2,274.9,278.9,282.2,311.9,273.3,264.9,288.3,282.2,277.4,239.7,296.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8NDT2","Putative RNA-binding protein 15B [OS=Homo sapiens]",9,8,15,7,890,97.1,9.85,23.52,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity","RBM15B","ENSG00000259956","","","",0.942,0.994,0.946,0.891,0.947,1,1,1,0.319330007898198,1,98.8,104.2,99.3,104.9,93.4,99.3,94.5,99.7,100.3,93.6,105.2,111,100.1,94,100.8,111.4,103.7,105.8,96.4,87.2,94.3,106.2,100.2,95.7,629.2,663.8,667.9,623.2,700.2,739,666.8,626.1,670.9,741.5,690.8,704.6,642.1,580.8,627.8,707,667.4,637,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","Q3C1V8","Brain-specific homeobox protein homolog [OS=Homo sapiens]",6,1,1,1,233,25.9,7.5,0,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BSX","ENSG00000188909","","","",0.944,0.911,0.882,1.035,0.803,1,1,1,1,0.764681518528873,101.6,98.1,94.9,107.6,111.4,86.4,103.1,102.7,95.5,98.7,120.1,99.2,96,86,115.6,103,113.3,108.8,112.6,126.4,95.7,87.4,36.3,99.6,150.4,149.9,139.4,144,175.3,144.7,140.1,125.6,168.7,150.3,165.4,158.8,164.4,184.4,139.7,127.5,53,145.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q7L311","Armadillo repeat-containing X-linked protein 2 [OS=Homo sapiens]",22,6,20,6,632,65.6,8.53,57.13,"","other membranes;mitochondrion","","ARMCX2","ENSG00000184867","","","",0.945,0.971,0.98,0.899,0.944,0.774834806617448,1,1,0.241472906299173,1,98.8,101.5,102.4,104.5,94,98.7,93.6,98.8,99.5,101.4,97.4,103.6,100.9,103.4,102.4,104.5,106,102.5,93.9,95.8,93.2,95.7,108.8,98.7,468.4,494,497.8,507.4,487,518,504.8,517.2,512.2,522.7,530.3,512.5,469.9,479.2,466,478.8,544.2,493.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9ULE6","paladin [OS=Homo sapiens]",18,12,25,12,856,96.7,6.54,43.12,"protein metabolism;other metabolic processes","cytosol;other cell component","other molecular function","PALD1","ENSG00000107719","","","",0.946,1.016,0.965,0.981,0.981,1,1,1,1,1,96.3,103.5,98.3,101.9,100,100,98.1,99.7,86.8,98,108.9,105.4,100.2,98.9,104.9,99.7,106.8,103.8,101.8,107.1,97.4,101.8,75,105.5,653.8,664.3,578.3,652.8,725.7,702.2,667.2,659.1,698.7,663.9,711.5,691.4,678.4,713.4,649,678.3,499.3,702.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P60900","Proteasome subunit alpha type-6 [OS=Homo sapiens]",54,12,65,12,246,27.4,6.76,149.53,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSMA6","ENSG00000100902","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","Regulation of expression of SLITs and ROBOs; Neddylation; Ub-specific processing proteases; Separation of Sister Chromatids; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; ER-Phagosome pathway; Downstream TCR signaling; UCH proteinases; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",0.947,0.958,0.986,0.982,0.88,1,1,1,1,0.374228387382022,98.7,99.9,102.9,104.3,102.4,91.8,93.6,104.7,99.2,100.9,98.7,100.3,103.4,101.8,108.9,96.3,111.3,104.8,102.9,108,97.9,92.2,78.7,96.3,2724.6,3048,2887.9,2938.7,2875.4,2921.8,3009.5,2964.5,3172.4,2803.7,3240.9,3050.9,2995.5,3145.7,2850.9,2685.3,2292.7,2804.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P13010","X-ray repair cross-complementing protein 5 [OS=Homo sapiens]",66,41,448,40,732,82.7,5.81,905.77,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","XRCC5","ENSG00000079246","Non-homologous end joining; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network","Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN","Non-homologous end-joining",0.948,0.98,0.991,0.979,0.966,0.759057232454981,1,1,1,1,97,100.3,101.4,102.3,100.2,98.8,96.3,98.7,97.4,100.7,98.7,100.9,100.6,101.8,102,98.2,104.3,102.7,99.4,100.9,100.6,102.2,95.4,99.2,15898.6,16299.6,16085,16631.1,16295.2,16654.2,16619.4,16814.1,16850.4,16212.5,17217.8,16964.3,16410.4,16663.6,16610.9,16882.6,15748.7,16381.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q08623","Pseudouridine-5'-phosphatase [OS=Homo sapiens]",12,2,7,2,228,25.2,5.31,11.08,"other metabolic processes","cytosol","other molecular function","PUDP","ENSG00000130021","","Pyrimidine salvage","",0.949,1.077,1.021,1.066,1.019,1,1,1,1,1,92.8,105.4,99.9,97.9,104.3,99.7,102.6,91.5,87.2,103.9,111.5,101.2,98,108.1,98.5,96.5,95.3,101.6,98.9,103.8,102.8,98.3,96.1,104.1,166.8,148.9,141.8,169,181.3,164.7,159.4,175.7,160.3,156.9,154.9,165.3,160.9,168.9,167.2,159.9,156.4,169.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q15573-1","TATA box-binding protein-associated factor RNA polymerase I subunit A [OS=Homo sapiens]",2,1,1,1,450,52.6,9.1,2.59,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus","nucleic acid binding activity","TAF1A","ENSG00000143498","","RNA Polymerase I Transcription Initiation; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; SIRT1 negatively regulates rRNA expression; RNA Polymerase I Transcription Termination","",0.95,0.875,0.871,0.729,0.866,1,1,1,1,1,107.7,99.2,98.7,113.4,82.7,98.2,120.2,104.5,112.9,104,131.6,75.2,109.1,103.5,88.4,122.9,75,118.9,86.6,105.4,74.9,106.7,57.2,102.9,29.3,25.5,27.5,25.4,32.1,18.3,26.6,25.2,21.6,30,18.3,29,21.1,25.7,18.3,26,13.9,25.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8NI60-1","Atypical kinase COQ8A, mitochondrial [OS=Homo sapiens]",2,1,2,1,647,71.9,6.99,4.31,"protein metabolism;other metabolic processes","other membranes;mitochondrion","kinase activity;other molecular function","COQ8A","ENSG00000163050","","","",0.952,1.036,1.073,1.089,1.005,1,1,1,1,1,92.8,101,104.6,97.5,106.1,98,93.3,73.5,103.5,101.6,108.5,90.8,105.2,106.4,97.5,94.1,98,100.6,116.8,106.7,102.8,104.1,98.5,98.1,83.7,66,92.9,91.2,97.5,81.6,94.4,95.5,87.6,84.5,88,90.4,104.9,95.8,92.3,93.5,88.4,88,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q4KWH8-1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 [OS=Homo sapiens]",11,15,19,15,1693,189.1,7.74,25.64,"other metabolic processes;signal transduction","plasma membrane;other membranes;other cell component","other molecular function","PLCH1","ENSG00000114805","Mesodermal commitment pathway; GPR40 pathway","Synthesis of IP3 and IP4 in the cytosol","Inositol phosphate metabolism; Metabolic pathways",0.952,0.99,0.982,0.975,0.968,1,1,1,1,1,97.4,101.3,100.4,102.3,99.7,99,90.9,97.9,100.5,101.1,104.1,101.8,101.1,99,100.9,99.7,106.8,102.8,100.9,99.8,100.2,102.8,90.2,99.5,1068.4,1150.1,1181,1188.2,1223.5,1196.6,1187.9,1163.8,1186.3,1171.5,1255.4,1208.1,1185.7,1172.8,1177.8,1208.2,1060,1169,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96PY5-3","Isoform 2 of Formin-like protein 2 [OS=Homo sapiens]",14,15,26,12,1092,124,7.66,64.59,"","","","FMNL2","","","","",0.953,0.97,0.98,0.957,0.979,1,1,1,1,1,97.9,99.7,100.7,102.8,98.3,100.6,105.8,98,97.2,99.1,101.7,99.8,99.1,102.6,100.8,102.8,101.7,103.2,99.5,98.4,95,100.7,93.9,100.8,1055.7,977.9,969.7,988.4,1015,995.4,988.4,1023.3,1005.9,1026.2,1014.6,1029.6,992.8,981.7,947.7,1005,937.4,1006.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q15797","mothers against decapentaplegic homolog 1 [OS=Homo sapiens]",6,3,5,1,465,52.2,7.31,11.45,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMAD1","ENSG00000170365","Bone morphogenic protein (BMP) signaling and regulation; Angiogenesis; Heart development; Neural crest differentiation; Mesodermal commitment pathway; Differentiation of white and brown adipocyte; Mesodermal commitment pathway; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Neovascularisation processes; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Development of ureteric collection system; Network map of SARS-CoV-2 signaling pathway; TGF-beta receptor signaling","Ub-specific processing proteases; Signaling by BMP; RUNX2 regulates bone development","TGF-beta signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Transcriptional misregulation in cancer",0.955,0.751,0.697,0.702,0.774,1,1,0.629661856555088,0.571778997077121,0.441063265306191,117.4,92.4,85.7,123,86.3,95.2,137.2,118.5,100.9,93.2,103.5,85.7,79.1,93.9,86.5,119.4,124.1,132.5,74.4,100.8,87.1,96,60.7,106.4,84.3,72.8,62,57.3,63.6,52.6,48.6,57.7,53.1,73.3,76.2,81.4,45.7,61.9,53.5,59,37.3,65.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P55199","RNA polymerase II elongation factor ELL [OS=Homo sapiens]",20,10,12,10,621,68.2,9.33,20.42,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ELL","ENSG00000105656","Interactome of polycomb repressive complex 2 (PRC2)","TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; Transcription-Coupled Nucleotide Excision Repair (TC-NER)","",0.956,0.985,0.938,1.016,1.005,1,1,1,1,1,97.2,100.2,95.4,101.7,103.3,102.2,97.3,97.4,95.4,99.2,100.3,101.1,102.9,95.5,95.2,101.8,97.3,103.5,111.5,100.5,103.4,102.3,88.1,107.4,475.2,475.8,466.2,484.6,489.9,493.9,503,466.4,465.4,497.2,475.5,505.5,544.7,491,505.3,499.8,430.6,524.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P41091","eukaryotic translation initiation factor 2 subunit 3 [OS=Homo sapiens]",46,18,83,18,472,51.1,8.4,174.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","EIF2S3","ENSG00000130741","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency","",0.956,0.932,0.925,0.973,0.942,1,1,1,1,1,100.2,97.6,96.8,104.7,102,98.7,100.5,103.7,98.9,95.1,97.9,100.4,97.2,96.2,105.1,95.2,110.4,105.1,102.3,108,100,99.9,85.2,99,6458.5,6665.1,6354.1,6110.6,6294.8,6455.9,6245,6182,6758.3,6121.6,7098.6,6754,6574.9,6941.8,6425.2,6420.7,5476.5,6363.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q8N4P3","Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [OS=Homo sapiens]",5,1,1,1,179,20.3,6.74,2.35,"","","other molecular function","HDDC3","ENSG00000184508","","","Purine metabolism; Metabolic pathways",0.958,1.012,0.73,0.993,0.743,1,1,0.515679520361682,1,0.613145124706924,105.7,111.7,80.6,110.4,109.6,82,134,95,104.4,110.3,96.7,110.9,79.5,79.2,90.1,109,112.9,98.9,108.2,109.7,101.7,81,80,98.5,111.7,79.2,87,91.9,80.6,92.4,66.3,66,75.1,90.8,94.1,82.4,90.2,91.5,84.7,67.5,66.6,82.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q02543","60S ribosomal protein L18a [OS=Homo sapiens]",56,13,88,13,176,20.7,10.71,142.95,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","other molecular function","RPL18A","ENSG00000105640","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",0.959,0.928,0.998,1.043,0.795,1,1,1,1,0.790735289905726,100.6,97.3,104.6,104.9,109.3,83.3,92.8,111.3,99.3,96,97.4,91.5,103.3,101.4,112.6,87.4,119.7,103.5,108,125.3,99.2,82.3,70.6,98.2,3763.2,4516.3,4030,3896.2,3951.8,3711.4,4192.1,4114.2,4567.7,3545.8,4857.6,4200.7,4380.3,5083.8,4026.3,3338.7,2864.4,3983.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y3F4","Serine-threonine kinase receptor-associated protein [OS=Homo sapiens]",68,21,239,21,350,38.4,5.12,565.03,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","STRAP","ENSG00000023734","TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer","Downregulation of TGF-beta receptor signaling","",0.96,1.007,0.991,0.993,1.027,1,1,1,1,1,96.4,101.1,99.5,100.4,99.6,103.1,94.4,94.7,97.4,101.3,98,99.3,97.8,103.6,96,98.7,97.8,100.2,97.9,95.6,103,101.3,122.7,100.3,8173.3,8197,8432.8,8764.3,8482.3,8598.4,8463,8965.7,8305.6,8540.5,8463,8673.1,8476.8,8277.8,8918.2,8767.3,10621.1,8683.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q567U6","Coiled-coil domain-containing protein 93 [OS=Homo sapiens]",13,9,11,9,631,73.2,8.15,17.5,"transport","other cytoplasmic organelle;other cell component","","CCDC93","ENSG00000125633","","","",0.961,1.033,0.951,0.943,0.957,1,1,1,1,1,98.6,106,97.6,102.6,96.8,98.3,100.7,99.5,106.4,95,113.5,108.3,99.8,85.6,102.9,109.4,100,104.9,102,95,98.9,101.9,75.7,100.4,467.6,462,494.1,441.1,527,502.9,463,397.3,477.9,507.8,464.1,486.8,473.7,440.8,459.2,472.8,351.3,466,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O14965","Aurora kinase A [OS=Homo sapiens]",16,5,11,5,403,45.8,9.39,24.71,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AURKA","ENSG00000087586","Gastric cancer network 1; EGF/EGFR signaling pathway","Regulation of TP53 Activity through Phosphorylation; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA","Oocyte meiosis; Progesterone-mediated oocyte maturation",0.962,0.939,0.931,1.026,1.09,1,1,1,1,1,97,94.7,93.9,100.9,103.4,110,93.1,98,105.4,95.7,90.4,96.5,99.7,91,94.8,99.3,101.8,102.5,103.3,106.1,104.4,111,93.1,113.8,235.1,247.5,266.4,241.7,228.3,243.8,252,229.9,239.6,250.8,257.3,258.9,261.1,268.2,263.9,280.5,235.2,287.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8IW41","MAP kinase-activated protein kinase 5 [OS=Homo sapiens]",5,2,3,2,473,54.2,7.78,6.95,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAPKAPK5","ENSG00000089022","MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; p38 MAPK signaling pathway","Regulation of TP53 Activity through Phosphorylation; MAPK6/MAPK4 signaling; Oxidative Stress Induced Senescence","MAPK signaling pathway",0.963,0.99,0.917,0.875,0.891,1,1,1,1,0.938604389241384,102.5,105.4,97.6,106.5,93.2,94.9,120.9,102,101.3,110.9,104.9,94.5,97.1,90.4,100.7,106,101.5,111.2,85.3,100.9,92.7,94.4,84.2,101.1,221.5,186.9,185.5,203.3,192.2,173.1,178,165.7,184.5,194.1,186,203.7,156.3,184.9,169.9,173,154.3,185.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UN86-2","Isoform B of Ras GTPase-activating protein-binding protein 2 [OS=Homo sapiens]",45,17,116,16,449,50.8,5.38,164.94,"","","","G3BP2","","","","",0.964,0.968,0.949,0.97,1.011,1,1,0.612595563173635,1,1,98.7,99.1,97.1,102.4,99.3,103.5,99.1,94.6,101,94.6,99.7,99.6,98.1,97.5,94.3,106.6,100.7,102.8,103.4,96.5,99.7,103.9,106.1,101.8,5799.1,5537.3,5910.5,5539.7,5834.1,5827.3,5744,5707.6,5516.8,6240.8,5892.2,6017.3,6054,5649.2,5837.5,6081.3,6208.1,5955.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8NBF6-1","Late secretory pathway protein AVL9 homolog [OS=Homo sapiens]",12,5,9,5,648,71.9,6.21,10.98,"other biological processes","other membranes;other cytoplasmic organelle;other cell component","","AVL9; KIAA0241","ENSG00000105778","","","",0.965,1.045,0.976,1.074,1.061,1,1,1,1,1,94.6,102.5,95.7,98,105.2,104,94.1,99.7,90.8,104.2,94.5,101.9,92.6,105.8,95.2,104.6,97.5,95.8,104.8,101.5,104.7,102.6,103.4,106.4,189.9,201,183.1,210.2,190.6,205.6,186.7,213.3,192,211,196.7,193.3,211.4,204.7,211.2,207,208.7,214.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P61313-1","60S ribosomal protein L15 [OS=Homo sapiens]",49,11,67,11,204,24.1,11.62,160.59,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","LOC111155115; NR1D2; Rpl15; RPL15","ENSAMEG00000003497; ENSAMEG00000024645; ENSBIXG00000012476; ENSBIXG00005007092; ENSBMUG00000012295; ENSBTAG00000033080; ENSCAFG00000005764; ENSCAFG00030022972; ENSCAFG00040022162; ENSCANG00000040764; ENSCATG00000039291; ENSCGRG00001021972; ENSCGRG00015016653; ENSCJAG00000043224; ENSCPOG00000030042; ENSCSAG00000009762; ENSECAG00000010157; ENSFCAG00000026237; ENSG00000174748; ENSGGOG00000024274; ENSHGLG00000000795; ENSLCNG00005011910; ENSMFAG00000043886; ENSMLEG00000031741; ENSMLUG00000013809; ENSMMUG00000006353; ENSMPUG00000012148; ENSMUSG00000012405; ENSNLEG00000003580; ENSOANG00000045456; ENSOCUG00000010961; ENSOGAG00000013056; ENSPANG00000015926; ENSPPAG00000032386; ENSPPYG00000014065; ENSPTRG00000014695; ENSRBIG00000024014; ENSRBIG00000033415; ENSRFEG00010011144; ENSRNOG00000008140; ENSRROG00000001983; ENSRROG00000015533; ENSRROG00000027506; ENSRROG00000028991; ENSRROG00000037650; ENSSHAG00000031281; ENSSSCG00000037030; ENSSSCG00070018008; ENSSSUG00005002593; ENSSTOG00000011153; ENSUAMG00000015536; ENSVURG00010022414; ENSVVUG00000028235","Cytoplasmic ribosomal proteins; Cytoplasmic ribosomal proteins; Cytoplasmic ribosomal proteins","L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",0.966,1.012,1.029,1.039,1.018,1,1,1,1,1,95.5,100.1,101.8,98.9,102.8,100.8,91.5,94.7,98.7,106.3,99.3,97.4,100.9,104.5,95.7,97.3,98.1,99.7,102,101.1,104.7,99.9,109.4,98.8,4067.2,4210.7,4385.8,4722.2,4412,4329.3,4485.8,4642.8,4252.6,4324.2,4360.3,4430.4,4532.4,4492.5,4655.2,4440.5,4860.9,4389.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q92618","Zinc finger protein 516 [OS=Homo sapiens]",9,10,12,10,1163,124.2,8.72,24.97,"stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF516","ENSG00000101493","Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects","","Thermogenesis",0.967,0.983,0.93,0.938,0.948,1,1,1,1,1,100.6,102.2,96.8,104.1,97.6,98.6,99.5,101.4,100.4,98.3,104,102,96.6,99.3,95,103.8,100,106.1,102.2,96.7,97.4,98.4,105.7,93.1,615.2,627.1,620.8,607.9,643.2,630.9,597.3,614.3,587.4,642.1,618.4,656.4,632,598,602.5,608.6,653.4,575.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P49720","proteasome subunit beta type-3 [OS=Homo sapiens]",49,10,33,10,205,22.9,6.55,86.92,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PSMB3","ENSG00000275903; ENSG00000277791","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of expression of SLITs and ROBOs; Neddylation; Downstream TCR signaling; Interleukin-1 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Orc1 removal from chromatin; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",0.968,0.937,0.959,1.001,0.83,1,1,1,1,0.965836722945412,102,98.7,101,105.3,105.4,87.5,89.1,109.4,100.4,97.2,96.6,102.7,99.5,96.3,117.3,90.5,117.8,103.7,103.8,109.8,98,85.1,86.1,96.5,1490.8,1831.3,1681,1627,1617.2,1718.1,1664.5,1611.4,1962.9,1514.5,1971.5,1735.7,1737.1,1838.4,1640.5,1424.9,1441.5,1615.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q12789-2","General transcription factor 3C polypeptide 1 [OS=Homo sapiens]",31,53,115,53,2109,238.7,7.3,217.74,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","GTF3C1","ENSG00000077235","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",0.97,0.95,0.94,0.916,0.925,1,1,1,0.453018569885246,0.140376775607669,102,100,98.9,105.2,96.4,97.4,103.4,100.5,102.4,99.4,103,100.4,99.3,95.8,103.2,103.6,107.5,105.6,96.5,98.3,96.7,99,87.7,97.7,4664.6,4536.3,4621.2,4484.2,4649.1,4529,4480.6,4321.2,4657.1,4674.1,4849.8,4765.6,4355.1,4437.2,4365.8,4468.1,3959.8,4410.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q7L2E3-2","Isoform 2 of Putative ATP-dependent RNA helicase DHX30 [OS=Homo sapiens]",38,33,77,33,1222,136,8.6,168.64,"","","","DHX30","","","","",0.97,0.979,0.986,0.969,0.974,1,1,1,0.839434833923529,0.799685761995693,99,99.9,100.6,102.1,98.9,99.5,99.1,99.1,102.6,97.5,100,101.6,96.1,102.4,100.8,101.2,102.2,107.2,99.1,100.7,94.8,99.6,96.1,99.8,2697.6,2696,2790.8,2652.1,2722,2764.7,2616.1,2787.2,2741.5,2753.9,2780.9,2917.1,2695.5,2741.2,2580.3,2709.9,2615.4,2716.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q5TC63","Growth hormone-regulated TBC protein 1 [OS=Homo sapiens]",11,3,6,3,336,38.5,8.78,2.46,"transport;other biological processes","","enzyme regulator activity","GRTP1","ENSG00000139835","","","",0.972,0.916,1.013,1.079,0.95,1,1,1,1,1,98.3,92.7,102.6,101.2,109.2,96.1,97.6,111.5,99.3,92.5,93.6,99.5,98.7,103.6,104.7,80.7,109.3,102.3,110.2,114.3,110.3,102.5,72.2,97.1,273,312,277.8,258.7,261.8,278.3,276,289.8,292.8,225.8,305.6,286,308.2,319.6,308.5,286.6,201.8,271.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O75351","Vacuolar protein sorting-associated protein 4B [OS=Homo sapiens]",38,14,32,11,444,49.3,7.23,58.84,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS4B","ENSG00000119541","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)","Endocytosis; Necroptosis",0.973,1.009,0.954,0.964,0.961,1,1,1,0.902737963572685,0.265454595744751,99.6,103.3,97.7,102.4,98.7,98.3,99.8,103.5,99.8,101.2,103.6,105.1,99.7,96.6,97.9,110,102.5,102.6,98.9,99.1,95.3,98.7,87.1,98.6,1146.7,1189,1146.3,1163.3,1190.1,1207.8,1145.6,1109.6,1125.3,1263.6,1177.3,1179.1,1136.9,1138.2,1095.3,1134.4,1001,1132.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P11047","Laminin subunit gamma-1 [OS=Homo sapiens]",42,54,195,54,1609,177.5,5.12,411.64,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi","extracellular structural activity","LAMC1","ENSG00000135862","Alpha 6 beta 4 signaling pathway; Complement system; Endoderm differentiation; miRNA targets in ECM and membrane receptors; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Malignant pleural mesothelioma","Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; L1CAM interactions; Laminin interactions; EGR2 and SOX10-mediated initiation of Schwann cell myelination","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Prion disease; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer",0.973,0.918,0.936,0.995,1.062,1,1,1,1,1,99.2,93.6,95.4,102,101.4,108.3,102.8,95.6,99.7,88.7,94,94,95.9,100.3,94.9,105.6,95.8,102.5,101.9,88.5,103,108.9,125.2,102.8,6900.8,6423,6696.4,5955.1,6316,6316.1,6440.3,6734.7,6375,7092.4,6431.3,6881.7,6844.7,5944.6,6914.2,7311.7,8406.4,6902.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P59998","Actin-related protein 2/3 complex subunit 4 [OS=Homo sapiens]",31,5,17,5,168,19.7,8.43,32.81,"cell organization and biogenesis","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ARPC4","ENSG00000241553","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",0.974,0.924,1.027,1.039,0.891,1,1,1,1,1,99.8,94.7,105.3,102.5,106.4,91.3,96.1,107.5,101.5,88.6,97,96.2,107,93.9,118.5,84.3,122.8,104.1,108.2,126.1,90.7,92.8,66.9,98,974.9,1090.7,1029.6,899.3,983.8,976.3,1085.4,952.6,1202.3,855.6,1245.6,1056.8,1097.7,1279.1,920,941.6,678.7,994.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P42694","Probable helicase with zinc finger domain [OS=Homo sapiens]",5,8,13,8,1942,218.8,7.42,28.52,"other biological processes","cytosol;nucleus;other cell component","other molecular function","HELZ","ENSG00000198265","","","",0.976,1.031,1.005,0.984,0.971,1,1,1,1,1,98.1,103.6,101,100.5,99,97.7,95.1,101.4,98.4,104,103.6,107.5,101.3,95.8,102.2,98.1,106.2,100.9,95.9,100.4,99.3,105.6,86.3,98,671,715.1,694.4,733.4,730.7,758.1,714.8,675.6,720.6,692,749.2,711.4,676.6,708.4,700.3,745.1,608.7,691,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9HCE5","N6-adenosine-methyltransferase subunit METTL14 [OS=Homo sapiens]",22,10,29,10,456,52.1,6.21,52.29,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","METTL14","ENSG00000145388","","Processing of Capped Intron-Containing Pre-mRNA","",0.976,1.041,1.01,0.955,1.034,0.876916741667226,1,1,1,1,97.4,103.8,100.7,99.7,95.2,103.2,97.6,91.9,97.1,102.4,103.6,104.4,98,100.5,100.9,105.9,99.5,98.7,95,93.8,103.2,102.9,102.9,101.9,1439.1,1354.2,1432,1509.1,1526.7,1539.7,1444.1,1481.2,1487.7,1561.8,1466.5,1454.7,1400,1382.6,1521.1,1517.2,1516.9,1502.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8IXI2-3","Isoform 3 of Mitochondrial Rho GTPase 1 [OS=Homo sapiens]",13,8,10,7,691,79.5,6.9,23.53,"","","","RHOT1","","","","",0.978,1.032,0.968,0.966,0.962,1,1,1,1,1,99.3,104.9,98.4,101.6,98.1,97.7,88.3,99.3,94.6,116,95.3,99.8,93,126.9,93.6,102.1,96.7,96.1,93.4,90.2,105.9,89.8,126,93,324.1,364.4,347,425.6,349.7,366.3,341.2,465.5,343.6,374.7,355,352.8,342.7,331,388.5,329.5,462.4,341.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P18583-6","Isoform E of Protein SON [OS=Homo sapiens]",23,30,136,1,2108,228,5.4,317.49,"","","","SON","","","","",0.979,1.054,0.958,0.938,1.043,1,1,1,1,1,98.4,105.9,96.2,100.5,94.3,104.8,96.2,103,94.4,85,103.6,115.3,108.5,94.1,93,98.3,93.5,102.3,109.4,91,92.2,102.6,94.3,123.3,50.4,53.9,49.4,44.5,54.3,60.4,56.8,49.3,48.7,51.5,49,53.6,57.3,47.7,48.3,53.7,49.4,64.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q0VDF9","Heat shock 70 kDa protein 14 [OS=Homo sapiens]",49,19,59,19,509,54.8,5.59,141.55,"stress response;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","HSPA14","ENSG00000187522","Parkin-ubiquitin proteasomal system pathway","Regulation of HSF1-mediated heat shock response","",0.979,1.002,0.975,0.998,1.018,1,1,1,1,1,98.4,100.6,98,100.5,100.3,102.3,96.8,99.3,99,99.4,101.2,103.9,98.6,97.9,104.2,98.5,101.1,101.5,98.7,105.1,100.9,102.9,87.6,103.5,2421.1,2482.5,2475.2,2486.5,2530.9,2597.1,2464.6,2447.6,2605.8,2462,2527.1,2538.5,2468,2627.1,2522.9,2572.3,2190,2588.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q15477","Helicase SKI2W [OS=Homo sapiens]",20,17,30,15,1246,137.7,6.06,71.97,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SKIV2L","ENSG00000204351; ENSG00000206353; ENSG00000223493; ENSG00000225737; ENSG00000228896; ENSG00000232616","","Association of TriC/CCT with target proteins during biosynthesis; mRNA decay by 3' to 5' exoribonuclease","RNA degradation",0.98,0.99,0.974,0.976,0.99,1,1,1,1,1,99.5,100.5,98.8,101.5,99.1,100.5,99.6,100.2,94.5,100.6,101.1,98.8,98.9,99.6,96.6,105.7,100.1,101.6,99.2,103.7,96.2,103.1,100.6,99.9,704.2,708.1,668.1,711.3,714.6,698.1,699.3,703.8,682.5,746.8,707.8,718.3,701,732.7,679.7,728.4,711.1,706.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96AX1","Vacuolar protein sorting-associated protein 33A [OS=Homo sapiens]",21,10,19,10,596,67.6,6.96,31.65,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","VPS33A","ENSG00000139719","Ebola virus infection in host; Network map of SARS-CoV-2 signaling pathway","","Salmonella infection",0.981,1.022,0.969,0.981,0.953,1,1,1,1,0.557038264817204,99.6,103.8,98.5,101.6,99.7,96.8,100.2,103.9,96.6,105.2,97.8,104.4,97.1,99.1,100.7,103,101.8,102.2,100.3,104.5,97.7,97.3,90,98.1,701.6,727.4,676.1,736.1,684.2,730.8,679.8,693.4,705,720.9,712.5,715.3,701.8,731.7,683.9,681.3,629.6,686.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q92785","Zinc finger protein ubi-d4 [OS=Homo sapiens]",40,15,37,14,391,44.1,6.33,55.63,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DPF2","ENSG00000133884","Tumor suppressor activity of SMARCB1","","",0.982,0.996,0.991,0.957,0.988,1,1,1,1,1,99.6,101.1,100.6,101.4,97,100.2,91.4,99.5,100.5,99.7,105.9,100.9,100.4,97.2,103,108.7,101.3,99.8,96.1,99.3,96.9,101.2,98.1,100.1,1036.8,1128.5,1140.7,1131.6,1201.4,1144.7,1139.4,1102.8,1168.9,1234,1149.2,1132.7,1090.8,1126.4,1099.3,1148.5,1113.6,1135.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H8H3","methyltransferase-like protein 7A [OS=Homo sapiens]",18,3,14,3,244,28.3,8.38,33.09,"other metabolic processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","METTL7A","ENSG00000185432","","Neutrophil degranulation","",0.984,0.95,0.966,0.957,0.894,1,1,1,1,0.719813465604497,102.6,99.1,100.8,104.3,99.8,93.3,94.8,106.1,103.1,104.3,99.5,97.1,101.3,97.7,102.6,100.2,107.1,104.8,100.3,110.7,90.8,97.9,87.9,93.7,821.3,919,893,903.1,862.2,841.3,877.2,846.6,888.4,867.6,927.2,907.7,868.7,959,786.6,847.6,761.4,811.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q58A45","PAN2-PAN3 deadenylation complex subunit PAN3 [OS=Homo sapiens]",3,3,3,3,887,95.6,8.57,4.87,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;kinase activity;other molecular function","PAN3","ENSG00000152520","","Deadenylation of mRNA","RNA degradation",0.984,1.021,1.042,0.996,0.968,1,1,1,1,1,98.2,101.9,104,99.8,99.4,96.6,98.3,91.8,106.7,89.5,102.1,102.4,104.1,93.1,112.8,99.9,98.8,107.9,99.5,107.3,99.4,102.1,87.7,96.7,191.4,178.6,207.6,174.1,198.6,199.3,202.7,181.1,219.5,194.5,192.2,210,193.6,208.8,193.4,198.7,170.7,188.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UGV2","protein NDRG3 [OS=Homo sapiens]",37,9,15,8,375,41.4,5.31,37.05,"signal transduction;other biological processes","other cell component","","NDRG3","ENSG00000101079","","","",0.985,0.95,0.924,0.879,0.914,1,1,0.681689526755154,0.633927822404957,0.495404667467337,104.6,100.8,98.1,106.2,93.4,97,107,104.9,101.9,101.2,97.8,101.2,100.6,90.9,98.4,101.5,108.2,106.5,93.7,103.4,93.5,98.4,97.4,93.5,1286.1,1260.9,1224.4,1215.6,1175,1216.4,1209.3,1092.4,1183.1,1219.6,1300.2,1280.1,1125.8,1242.4,1123.2,1182.2,1170,1124.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8IXI1","Mitochondrial Rho GTPase 2 [OS=Homo sapiens]",27,10,32,9,618,68.1,5.86,88.53,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion","other molecular function","RHOT2","ENSG00000140983","","RHOT2 GTPase cycle","Mitophagy",0.986,1.021,1.038,1.011,1.023,1,1,1,1,1,97.4,100.7,102.5,98.7,99.7,101,99.6,97.8,98.4,99.6,101.8,102.5,99.4,103.5,104.9,99.7,97.2,101.8,89.2,100.8,100.8,102,98.9,102.1,964.8,946.8,952.7,964.8,985.7,992.2,962.5,1002.6,1015.4,965.8,941.3,985.4,863.9,976,976.2,988.1,957.5,988.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P24666-1","Low molecular weight phosphotyrosine protein phosphatase [OS=Homo sapiens]",53,5,25,2,158,18,6.74,71.8,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","ACP1","ENSG00000143727; ENSGGOG00000015577; ENSPTRG00000011605","VEGFA-VEGFR2 signaling pathway","","Thiamine metabolism; Riboflavin metabolism; Metabolic pathways; Adherens junction; Chemical carcinogenesis",0.987,0.975,0.937,0.991,0.951,1,1,1,1,1,101.4,100.2,96.3,102.7,101.8,97.7,105.4,95,102.3,101,101.8,95.3,94.7,97.1,100.2,107.7,103.6,92.7,102.6,111.6,96,98.5,93.7,100.8,414.4,373.7,402.1,397.1,400.3,374.7,372.3,381.6,393.9,423.4,407.3,364.6,403.5,438.9,377.6,387.2,368.4,396.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9P1U1-1","Actin-related protein 3B [OS=Homo sapiens]",25,8,34,4,418,47.6,5.88,59.14,"","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTR3B","ENSCANG00000039781; ENSCATG00000043872; ENSCCAG00000019061; ENSCJAG00000019650; ENSCSAG00000006554; ENSG00000133627; ENSMFAG00000034566; ENSMMUG00000018920; ENSMNEG00000033219; ENSPANG00000006816; ENSPPYG00000018206; ENSPTRG00000019897; ENSRROG00000045018","","","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",0.988,1.024,1.014,0.978,1.016,1,1,1,1,1,98.5,102.1,101.1,99.7,97.5,101.2,98.5,110.3,90.6,100.9,102,107.9,101,98.4,102.8,102.4,99.3,99.6,97.4,94.9,100,101.2,89.4,103.3,352.7,395.1,324.6,361.5,365.5,386.6,362,352.4,368.3,366.9,355.7,356.8,348.9,339.9,358.1,362.4,320.3,370,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q969N2","GPI transamidase component PIG-T [OS=Homo sapiens]",12,6,9,6,578,65.7,8.38,26.11,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","","PIGT","ENSG00000124155","IL-18 signaling pathway","Attachment of GPI anchor to uPAR","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways",0.99,1.027,1.021,1.018,0.956,1,1,1,1,1,98.8,102.5,101.9,99.8,101.6,95.4,94.5,96.2,96.2,110.2,97.5,99.8,99.2,118.1,96.2,97.7,85.3,97.2,101,86.9,98.9,92.9,139.5,92.6,370.7,377.4,377.3,432.3,382.2,391.4,389.1,463,377.3,383.4,334.7,381.1,396.1,340.9,388,364.4,547,363.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8WUF5","RelA-associated inhibitor [OS=Homo sapiens]",2,2,2,2,828,89,6.81,4.08,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PPP1R13L","ENSG00000104881","IL-18 signaling pathway","Regulation of TP53 Activity through Association with Co-factors","",0.991,1.021,1.005,1.027,1.186,1,1,1,1,1,95.5,98.4,96.7,96.3,98.9,114.3,105.7,96.4,97.3,85.7,100.2,110.3,101.5,91.9,98.6,98.1,99.4,95.3,105.6,83.1,100.7,118.2,95.6,116.4,192.2,175.2,176.8,155.8,182.2,200.4,184.6,167.1,179.2,178.3,180.7,173.2,192,151.1,183.1,214.8,173.8,211.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H0F7","ADP-ribosylation factor-like protein 6 [OS=Homo sapiens]",24,4,5,4,186,21.1,8.54,9.49,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","ARL6","ENSG00000113966","Ciliopathies","BBSome-mediated cargo-targeting to cilium","",0.992,0.986,1.038,1.052,1.011,1,1,1,1,1,97.9,97.3,102.4,98.7,103.8,99.8,97.8,113.3,96.6,91.5,102.4,97.3,100.1,102.4,107.1,95.4,98.6,105.8,101.6,111.8,103.7,99.7,74.9,99.9,168.3,194.9,166.1,157.3,176.1,167.3,172.2,176.1,184.3,164.2,169.7,182,174.8,192.4,178.5,171.6,128.9,171.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9HD45","Transmembrane 9 superfamily member 3 [OS=Homo sapiens]",11,6,24,6,589,67.8,7.21,40.99,"other biological processes","other membranes","","TM9SF3","ENSG00000077147","","","",0.994,1.034,1.008,1.048,1.022,1,1,1,1,1,97.6,101.6,99.1,98.3,103,100.4,96.5,103.2,99,100.6,103,104.6,98.4,100.4,102.8,92.8,101.6,99.6,103.4,104.4,106.2,101.8,74.5,107,1026.9,1097.8,1052.7,1069.9,1095.3,1112.9,1047.1,1068.1,1093.6,987.5,1080.5,1059.5,1099.5,1110.5,1129.3,1082.9,792.7,1138.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P49368-1","T-complex protein 1 subunit gamma [OS=Homo sapiens]",68,38,286,37,545,60.5,6.49,613.53,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","CCT3","ENSG00000163468; ENSPPAG00000042161","16p11.2 proximal deletion syndrome","Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Prefoldin mediated transfer of substrate  to CCT/TriC; Folding of actin by CCT/TriC","",0.995,1.006,1.001,0.989,0.977,1,1,1,1,1,100,101.2,100.6,100.5,99.5,98.2,100,99.9,99,102.1,99.8,101.1,105,99.9,100.6,98.3,100.5,100.6,99.4,98.6,101.2,100.1,95.5,98.2,12215.4,12207.4,12096,12477.7,12192.1,12350.9,12823.6,12209,12287.3,12010.5,12273.6,12290.5,12143.2,12043,12358.2,12232.3,11666.2,11995.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P61353","60S ribosomal protein L27 [OS=Homo sapiens]",50,7,27,7,136,15.8,10.56,63.25,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPL27","ENSG00000131469","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",0.995,1.003,1.033,1.066,0.912,1,1,1,1,0.973152760947259,99.4,100.2,103.1,99.9,106.4,91.1,88.2,109.1,98,103,98.8,98.2,100.3,101.7,109.4,95,108.7,98.5,104.6,115.9,105,89.8,76.6,99.1,1338.5,1655.3,1487.1,1562.1,1499.4,1489.9,1521.7,1543.3,1660.7,1442.1,1648.6,1494.6,1587.4,1759.2,1593.1,1363.1,1161.6,1504.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O43795","Unconventional myosin-Ib [OS=Homo sapiens]",20,21,52,21,1136,131.9,9.38,118.64,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1B","ENSG00000128641","","","Pathogenic Escherichia coli infection",0.996,1.005,1.004,1.037,1.013,1,1,1,1,1,98.7,99.6,99.5,99.1,102.8,100.4,99.4,98.5,99.1,99.9,98.5,104.4,98,99.8,104.8,95.4,101,99.4,103.2,104.1,100.5,100.7,90.5,102.8,2425.9,2403.8,2418.8,2440.2,2404.7,2549.3,2391.7,2437.6,2559.2,2328.3,2467.2,2427.8,2518.9,2542.7,2452.6,2459.8,2209.4,2510.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O43765","Small glutamine-rich tetratricopeptide repeat-containing protein alpha [OS=Homo sapiens]",38,11,72,11,313,34,4.87,137.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","SGTA","ENSG00000104969","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",0.998,1.02,1.021,1.055,1.016,1,1,1,0.119723191195735,1,98,100.2,100.3,98.2,103.6,99.8,98,98,101.2,100.2,100.2,98.6,98.6,100.4,100.3,98.3,99.8,94.2,104,103.5,103.6,99.8,98,103.1,3585.1,3585,3701.8,3666.7,3666,3607.7,3607.5,3670.6,3669.2,3594,3650.2,3444.9,3805.6,3784.5,3791.1,3650.1,3586.1,3771.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P52888","thimet oligopeptidase [OS=Homo sapiens]",33,21,80,21,689,78.8,6.05,164.58,"protein metabolism;other metabolic processes","cytosol;mitochondrion","other molecular function","THOP1","ENSG00000172009","","Antigen processing: Ubiquitination & Proteasome degradation","Renin-angiotensin system; African trypanosomiasis",0.998,1.04,1.015,1.034,1.016,1,1,1,1,1,98.1,102.2,99.8,98.3,101.7,99.9,98.3,104.2,98.8,97.2,104.4,103,100.6,98.4,105.1,99.5,99.1,98.8,105.1,102.4,101.4,100.6,79.9,103.3,2409.7,2556.2,2423.8,2383.2,2559.5,2525.4,2466.2,2412.9,2577.4,2440.8,2429.3,2424.2,2577.4,2512.4,2486.1,2467.8,1959.9,2533.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P11388-1","DNA topoisomerase 2-alpha [OS=Homo sapiens]",48,64,293,48,1531,174.3,8.72,580.9,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP2A","ENSG00000131747","Gastric cancer network 1; Gastric cancer network 2; Retinoblastoma gene in cancer","SUMOylation of DNA replication proteins; Transcription of E2F targets under negative control by DREAM complex","Platinum drug resistance",0.999,0.905,0.985,1,1.021,1,0.217462543418121,1,1,1,101.4,91.8,100,101.5,101.6,103.7,101,103.5,101.9,89.4,92.3,93.4,98,100.5,103.1,97.4,102.6,102,102.8,102,102.1,107.1,96.8,104.2,14710.1,15069.6,14846.4,13016.1,13442.3,13597.9,14280.4,14637.5,15020.8,14192.7,14941.8,14860.9,14973.5,14856.7,14865.8,15594.1,14107.5,15180.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96CW5","Gamma-tubulin complex component 3 [OS=Homo sapiens]",13,9,23,9,907,103.5,8.12,44.67,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","TUBGCP3","ENSG00000126216","15q11.2 copy number variation syndrome","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","",1,1.045,0.975,0.967,0.992,1,1,1,1,1,100.4,104.9,97.8,100.3,97,99.6,100.5,94.7,103,105,101.8,112.2,96.5,97.9,103.5,100.4,99.4,101.7,97.1,100.7,95.6,99.7,88.3,101.9,698.4,658.1,716.2,729.7,707.4,779.9,670.8,680.6,719.7,698.2,691.2,707.2,674.8,699.9,664.5,692.9,613.5,708.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O14910","Protein lin-7 homolog A [OS=Homo sapiens]",15,4,11,2,233,26,8.72,19.9,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","LIN7A","ENSG00000111052","","Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle","",1.001,1.053,1.001,1.026,0.987,1,1,1,1,1,99,104.1,99,98.9,101.4,97.6,100,92.7,104.4,106.1,105.2,93.5,100.1,104.8,91.2,113.6,99.9,95.7,102.5,103.4,95.6,90.6,98.7,102,440.7,408.6,460,467.7,463.8,412,440.9,461.7,401.9,500.7,440.3,421.6,451.8,455.4,421.4,399.2,434.7,449.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8TBC4-1","NEDD8-activating enzyme E1 catalytic subunit [OS=Homo sapiens]",57,18,69,18,463,51.8,5.45,169.33,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBA3","ENSCANG00000031920; ENSCATG00000043878; ENSG00000144744; ENSMFAG00000036648; ENSMMUG00000008620; ENSMNEG00000038119; ENSPANG00000021492; ENSPTRG00000015095; ENSRBIG00000044270; ENSRROG00000035874","Hijack of ubiquitination by SARS-CoV-2","Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation","Ubiquitin mediated proteolysis",1.002,1.007,0.932,0.956,0.927,1,1,0.0464196466667966,0.508733730182266,0.030231788402857,103.2,103.7,96,103,98.5,95.5,106.3,103.3,102.3,105.2,103.8,101.2,96.1,96.6,94,100.3,105.3,103.1,98.6,100.2,97.3,94.5,95.6,96.1,2228.2,2165.1,2144.9,2204.9,2175.3,2121.6,2013.6,2025.1,1969.8,2102.6,2207.7,2160.2,2066.2,2099.1,2040.1,1980.6,2002.5,2014.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8TAV0-1","Protein FAM76A [OS=Homo sapiens]",21,7,11,5,307,35,9.19,21.55,"","nucleus","","FAM76A","ENSANAG00000034741; ENSCATG00000033886; ENSCCAG00000032340; ENSCJAG00000009327; ENSCSAG00000000999; ENSG00000009780; ENSGGOG00000006690; ENSMMUG00000012243; ENSMNEG00000027606; ENSPPYG00000001656; ENSPTRG00000000414; ENSRBIG00000031849; ENSRROG00000033795; ENSSBOG00000026158","","","",1.004,1.038,0.989,0.998,0.986,1,1,1,1,1,100.1,103.5,98.7,99.8,99.6,98.3,103.1,98.2,100.4,103.8,96.2,105.3,101.8,98.9,95.8,102.1,93.2,100.1,95.6,112.2,99.9,98.6,94.6,100.1,725.1,690.5,706.1,730,676.1,740.6,715.7,695.6,673.8,718,655.4,703.5,672.2,789.1,702.1,693.4,665.2,703.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9C0H5","Rho GTPase-activating protein 39 [OS=Homo sapiens]",3,4,4,4,1083,121.2,7.5,10.15,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","ARHGAP39","ENSG00000147799","","CDC42 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Inactivation of CDC42 and RAC1","",1.005,1.111,1.09,1.08,1.088,1,0.584355841016153,0.279469339719877,0.604969506682483,0.323129047937767,94.6,104.6,102.6,94.1,101.6,102.4,94.4,94.7,102.2,106.7,104.8,96.5,102.6,107.6,102.8,96.6,84.8,94.3,98.1,101.8,103.5,101.9,102.6,104.1,115.4,115.8,125,130.3,128.1,118,125.4,131.5,125.6,118.1,103.6,115.2,119.9,124.4,126.5,124.5,125.4,127.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NV88-1","integrator complex subunit 9 [OS=Homo sapiens]",15,8,18,8,658,73.8,6.33,28.16,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","","INTS9","ENSCCAG00000005937; ENSG00000104299; ENSGGOG00000017009; ENSRBIG00000038084; ENSRROG00000040531","","RNA polymerase II transcribes snRNA genes","",1.005,1.021,1.014,1.055,1.003,1,1,1,1,1,98.9,100.4,99.8,98.4,103.8,98.7,99.6,103.3,93.1,97,101.1,101.9,94.4,100.5,110.6,98.7,99.1,99.5,97.6,114.8,104.6,104.9,80,99.4,561,582,524.1,546.6,569.5,573.7,531.7,566,623.2,555.9,558,560.6,549.7,646.4,588.9,590.9,450.3,560,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","Q13216-1","DNA excision repair protein ERCC-8 [OS=Homo sapiens]",2,1,1,1,396,44,6.35,0,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","ERCC8","ENSCATG00000030457; ENSCSAG00000016051; ENSG00000049167; ENSNLEG00000002757; ENSPPAG00000029388; ENSPTRG00000016905","Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum","Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Neddylation; Formation of TC-NER Pre-Incision Complex","Nucleotide excision repair; Ubiquitin mediated proteolysis",1.007,1.051,0.95,0.831,0.861,1,1,1,1,1,106,110.7,100,105.3,87.5,90.6,110.4,108.2,87.7,97.7,112.9,114,105.4,102.1,88.1,125.8,107.4,89.4,91.5,86.9,89.3,98.8,92,92.5,57.5,56.4,45.7,50.9,58.8,59.4,54.9,53.2,45.9,65.5,56,46.5,47.6,45.3,46.5,51.5,47.9,48.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P78318","Immunoglobulin-binding protein 1 [OS=Homo sapiens]",30,8,18,8,339,39.2,5.38,34,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;other molecular function","IGBP1","ENSG00000089289","16p11.2 proximal deletion syndrome","","Autophagy; Autophagy",1.008,1.052,1.075,1.06,1.087,1,1,1,1,0.879909967109844,96.3,100.5,102.7,95.5,101.2,103.8,101.9,91.2,94.7,98.8,101.9,98.9,101.1,105.4,92.8,99.4,91.5,94,99.6,95.2,107.4,102.1,126.7,97.4,603.4,540,560.9,584.7,603.1,585.4,598.4,624,549.3,588.7,541.7,556.4,589.7,563.9,636,604.6,750.2,576.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q01064","Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [OS=Homo sapiens]",2,1,1,1,536,61.3,5.52,2.6,"developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","PDE1B","ENSG00000123360","G protein signaling pathways; Phosphodiesterases in neuronal function","G alpha (s) signalling events; cGMP effects; Cam-PDE 1 activation","Purine metabolism; Metabolic pathways; Calcium signaling pathway; Olfactory transduction; Taste transduction; Renin secretion; Morphine addiction",1.009,1.185,1.164,1.033,1.167,1,1,1,1,0.857403526424071,92.3,108.4,106.5,91.5,94.5,106.8,109.6,85.6,92.1,108.2,99.3,111.2,91.2,106.3,109.8,86.1,95.8,91.3,94.3,93.4,109.3,101.4,108.3,106.6,106.3,83,89.4,105,96.3,107.9,88.5,103.1,106.6,83.5,93,88.6,91.5,90.6,106.1,98.4,105.1,103.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9BTV7","CDK5 and ABL1 enzyme substrate 2 [OS=Homo sapiens]",15,4,5,4,478,52.2,9.82,5.14,"cell cycle OR cell proliferation;other biological processes","","","CABLES2","ENSG00000149679","","Factors involved in megakaryocyte development and platelet production","",1.01,0.971,0.951,1.015,0.886,1,1,1,1,0.956873025404361,103.9,99.9,97.9,102.9,104.4,91.1,104.2,103.8,111,78.9,100.2,107.2,89.8,98.2,102.6,116.4,103.2,100.5,104.8,109.7,93.7,88.9,91.4,95.9,71.6,71.4,76.3,54.2,68.9,73.7,61.8,67.5,70.5,80,70.9,69.1,72,75.4,64.4,61.1,62.8,65.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O75369-8","Isoform 8 of Filamin-B [OS=Homo sapiens]",68,132,613,1,2633,281.5,5.71,1316.89,"","","","FLNB","","","","",1.011,1.041,1.018,1.012,1.058,1,1,1,1,0.493405083500123,98.8,101.7,99.5,97.7,98.9,103.3,99.4,95.5,98.9,101.6,102.9,101.8,100.9,99.6,96.4,99.6,94.2,97.8,99,97.5,101,103.5,111.3,98.8,20423.4,19634.3,20330.3,20886.3,21148.3,20928.5,20739.2,20467.6,19811.1,20466.8,19360.4,20101.6,20349,20045.5,20763,21258.2,22873.7,20298.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9ULV4","coronin-1C [OS=Homo sapiens]",46,19,76,19,474,53.2,7.08,130.72,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CORO1C","ENSG00000110880","","","",1.012,1.006,0.981,1.002,0.987,1,1,1,1,1,101.4,100.8,98.3,100.2,100.4,98.9,105.2,97.6,101.7,94.4,101.1,102.1,98.6,98.2,99.2,100.2,100.5,101.8,102.8,98.6,100.7,103.8,94.3,99.2,3609.4,3349.4,3489,3238.3,3467.2,3503.1,3382.8,3368.2,3404.9,3438.1,3447.8,3492.2,3526.1,3381.6,3455.5,3561.8,3235.1,3403.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P49761-1","Isoform 1 of Dual specificity protein kinase CLK3 [OS=Homo sapiens]",9,3,6,3,490,58.6,9.52,8.39,"","","","CLK3","","","","",1.013,1.038,1.03,1.036,1.035,1,1,1,1,1,98.8,101.2,100.4,97.5,101,100.9,105.6,97.8,98.5,100.9,107.5,95.4,100.2,97.8,101.6,102.9,97.3,93.2,101.4,100.7,98.5,96.9,100.6,103,162.2,150.2,151.3,155,165,146.5,153.8,150.2,155.9,158,149.3,143.1,155.7,154.7,151.2,148.8,154.5,158.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9HAS0","Protein Njmu-R1 [OS=Homo sapiens]",26,6,7,6,396,44.6,5.03,15.59,"cell organization and biogenesis;transport","ER/Golgi;other cell component","","C17orf75","ENSG00000108666","","","",1.015,0.916,0.911,0.933,0.905,1,1,1,1,0.868144450674304,107.2,96.7,96.2,105.6,98.5,95.6,107.4,107.8,106.3,96.9,96.4,104.3,96.4,101.5,87.5,108.9,104.8,105.8,107.4,98.7,96.5,95.8,70.8,106.7,213.6,214.4,211.5,192.7,191.7,207.5,191.7,201.9,174,216.6,208.5,210.5,213.6,196.3,191.9,190.5,140.8,212.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y4X0","AMME syndrome candidate gene 1 protein [OS=Homo sapiens]",10,3,4,2,333,35.4,8.63,6.99,"","mitochondrion;nucleus","","AMMECR1","ENSG00000101935","","","",1.016,0.997,1.082,1.052,0.855,1,1,1,1,0.811467967146757,101.5,99.7,108.2,100,105.1,85.5,96.6,99.6,104.3,108.8,97.8,97.3,106.2,91.5,113.9,93.3,113.9,98.1,114.8,103.2,101.2,98.1,77.5,83.9,136.7,141,147.6,153.9,138.4,137.7,150.2,129.4,161.2,132,161.2,138.8,162.4,146,143.2,138.7,109.7,118.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96HS1-1","Serine/threonine-protein phosphatase Pgam5, mitochondrial [OS=Homo sapiens]",42,11,48,11,289,32,8.68,121.29,"protein metabolism;other metabolic processes;other biological processes","other membranes;mitochondrion","enzyme regulator activity;other molecular function","PGAM5","ENSG00000247077; ENSGGOG00000010046; ENSPTRG00000005657","NRF2-ARE regulation","","Mitophagy; Necroptosis; TNF signaling pathway",1.017,1.015,1.042,1.033,0.968,1,1,1,1,1,100.5,100.3,102.9,98.7,102,95.6,98,103.6,100.6,100.4,101.4,100.3,103.1,99.4,105.1,97.1,102.2,98.9,102.2,102.4,99,95.8,90.1,100.4,1898.8,2006.7,1949.5,1945.7,1963.3,1943.4,1996.4,1925,2035.2,1881,1979.8,1916.2,1980.1,1984.5,1917.2,1855.1,1745.2,1945.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q08379","Golgin subfamily A member 2 [OS=Homo sapiens]",28,21,40,21,1002,113,5.02,92.9,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","GOLGA2","ENSG00000167110","","COPI-mediated anterograde transport; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization","",1.019,1.033,0.945,0.971,0.998,1,1,1,1,1,102.5,103.9,95,100.6,97.7,100.4,107.2,96.3,102.4,93.1,108.8,103.8,94.6,94.9,100.3,107.1,100.5,100.4,101,92.9,97.6,109.1,89.8,100.3,1822.8,1637.7,1741.9,1584.4,1850.3,1765.7,1609.7,1614.7,1706,1821.4,1709.2,1707.4,1717.6,1579.9,1660.1,1856.2,1526.7,1705.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9BT25","HAUS augmin-like complex subunit 8 [OS=Homo sapiens]",21,6,9,6,410,44.8,7.06,16.49,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","HAUS8","ENSG00000131351","","Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",1.02,1.149,1.135,1.032,1.024,1,1,1,1,1,96.3,108.4,107.1,94.3,97.3,96.6,95,89.5,97.2,107,109.7,101.2,105.7,111.8,96,103.4,93.1,90.5,96.1,89.5,99.2,95.3,126.5,93.3,358.8,337.9,367,404,414.4,382.3,399.2,422.1,362.5,390.3,351.6,341.8,362.8,338,374.7,360,477.5,352.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P62263","40S ribosomal protein S14 [OS=Homo sapiens]",38,7,101,7,151,16.3,10.05,285.12,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","RPS14","ENSG00000164587","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); rRNA modification in the nucleus and cytosol","Ribosome; Coronavirus disease",1.021,0.928,0.993,1.022,0.978,1,1,1,1,1,103.1,93.7,100.3,101,103.2,98.7,95.1,102.2,102.1,103.7,91.8,92.9,99.4,107.3,97.9,88.8,100.1,100,100.9,102.3,103.1,93.5,121,97.8,3628.8,3897.4,3895.5,3956.5,3502.9,3542.9,3790.1,4091.4,3734.8,3388.7,3818.8,3816.2,3849.4,3901.9,3931.1,3567.5,4613.7,3732,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9BQ90","Kelch domain-containing protein 3 [OS=Homo sapiens]",7,2,2,2,382,43.1,8.07,4.45,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","KLHDC3","ENSG00000124702","","XBP1(S) activates chaperone genes","",1.023,1.108,1.139,1.043,1.051,1,1,1,1,1,96.4,104.5,107.4,94.3,98.4,99.1,114.5,93.8,93.6,107.1,87.5,101.6,104.4,111.8,88.5,91.7,90,107.9,95.6,75.4,104.7,96.3,140.6,95,87,71.3,71.2,81.4,66.5,77.2,79.4,85,67.2,69.7,68.4,82,72.7,57.3,79.6,73.2,106.9,72.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","Q96LL9","DnaJ homolog subfamily C member 30 [OS=Homo sapiens]",4,1,1,1,226,25.9,10.49,0,"other metabolic processes;developmental processes;other biological processes","other membranes;mitochondrion","","DNAJC30","ENSG00000176410","7q11.23 copy number variation syndrome","","",1.023,0.981,0.887,0.971,1.059,1,1,1,1,1,103.6,99.4,89.9,101.3,98.4,107.3,103.9,87.2,102.1,97.9,140.6,93.4,88.6,60.3,121.7,105.1,99.4,99.8,62.1,126,96.9,115.6,93.7,105.7,14.4,12.1,14.1,13.6,19.5,12.9,12.3,8.4,16.9,14.5,13.8,13.8,8.6,17.4,13.4,16,13,14.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UNM6","26S proteasome non-ATPase regulatory subunit 13 [OS=Homo sapiens]",62,21,98,21,376,42.9,5.81,196.85,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD13","ENSG00000185627","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Ub-specific processing proteases; Degradation of beta-catenin by the destruction complex; Degradation of AXIN; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",1.025,1.004,1.04,1.011,0.983,1,1,1,1,1,101.4,99.4,102.9,99,100.1,97.2,102.7,105.4,99.4,96.8,100.8,100.6,104.2,95.2,106,94.4,106.4,100.2,101.4,106.9,97.2,98.5,82.3,101.7,4880.5,5006.9,4722.2,4600.9,4788.5,4782.5,4953.9,4521.9,5034.9,4483.8,5057.6,4762.6,4816.7,5079.4,4618.6,4679.7,3912.8,4833,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q6IQ55","tau-tubulin kinase 2 [OS=Homo sapiens]",1,1,1,1,1244,137.3,7.01,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","TTBK2","ENSG00000128881","Genes related to primary cilium development (based on CRISPR); Ciliopathies","Anchoring of the basal body to the plasma membrane","",1.025,1.183,1.005,0.932,0.969,1,1,1,1,1,100.6,116.1,98.6,98.1,91.5,95.1,102.3,100.7,93.9,101.7,116.2,130.9,91.5,101,98.7,98.3,95.9,98.7,91.6,109.7,91.1,95.2,79.2,103.3,78.9,77.7,72.5,78.5,89.6,101,70.6,77.9,76.2,75.8,74,76.2,70.7,84.7,70.3,73.5,61.1,79.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P48637","glutathione synthetase [OS=Homo sapiens]",40,14,46,14,474,52.4,5.92,96.42,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol","other molecular function","GSS","ENSG00000100983","Glutathione metabolism; Trans-sulfuration and one-carbon metabolism; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases; Metapathway biotransformation Phase I and II","Glutathione synthesis and recycling; Defective GSS causes GSS deficiency","Cysteine and methionine metabolism; Glutathione metabolism; Metabolic pathways; Biosynthesis of cofactors; Ferroptosis",1.027,1.023,1.029,1.016,0.984,1,1,1,1,1,101.3,101,101.6,98.7,100.3,97.1,98.9,102.2,102.5,100.8,101.9,104.4,102.5,94.8,103.5,97.3,101,99.6,101.2,104.2,100,98.4,88.6,98,1145.6,1183.9,1187.2,1166.6,1180.1,1208.7,1186.6,1097.3,1198.8,1126.9,1169.9,1153.3,1171.3,1206.8,1158,1139.4,1026.3,1134.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96CC6","Inactive rhomboid protein 1 [OS=Homo sapiens]",2,2,2,2,855,97.3,8.44,4.47,"cell cycle OR cell proliferation;protein metabolism;transport;other biological processes","other membranes;ER/Golgi","other molecular function","RHBDF1","ENSG00000007384","","","",1.028,1.126,1.245,1.241,1.129,1,1,0.914057762256789,1,0.923140833495442,91.2,99.8,110.3,88.6,110,100,89.2,86.9,96.1,94.8,99,97.7,108,122.1,101.2,86.8,79.9,92.7,97.6,115.2,107.6,86.6,140.5,97.9,97.7,95.2,105.2,103.8,108.5,107,118.2,133.7,110.8,95,87.5,101.5,106.9,126.1,117.9,94.8,153.9,107.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q7Z4R8","UPF0669 protein C6orf120 [OS=Homo sapiens]",14,1,4,1,191,20.8,4.84,13.01,"other biological processes","non-structural extracellular;other cytoplasmic organelle","","C6orf120","ENSG00000185127","","Neutrophil degranulation","",1.029,0.931,1.084,0.999,0.975,1,1,1,1,1,102.6,92.8,108,99.7,99.6,97.2,99.8,101.9,98.4,113.6,89.2,90.3,105.1,112.7,96.9,98.8,97,93.5,94.2,96.9,111.1,82.4,123.7,94.6,134.6,137.4,132.7,153.2,120.2,121.7,141.7,151.9,130.7,133.2,130.8,126.1,127,130.7,149.8,111.1,166.9,127.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q92626","peroxidasin homolog [OS=Homo sapiens]",13,15,20,15,1479,165.2,7.17,39.26,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi","signal transduction activity or receptor binding;extracellular structural activity;other molecular function","PXDN","ENSG00000130508","EGF/EGFR signaling pathway","Crosslinking of collagen fibrils","",1.03,1.048,1.046,1,1.033,1,1,1,1,1,100.3,102.1,101.9,97.4,97.4,100.7,101.8,99.3,100.8,103.8,101.1,102.6,102.4,97.8,103.8,97.5,97.8,98.6,91.9,98,97.8,101.1,99.7,104.2,930.1,907.4,920.5,948,923.6,937,935.2,893.3,948.1,890.3,893.8,900.7,839.4,894.9,893.8,923.6,911.1,952,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P29323","Ephrin type-B receptor 2 [OS=Homo sapiens]",4,3,3,2,1055,117.4,6.55,5.15,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","EPHB2","ENSG00000133216","Microtubule cytoskeleton regulation; Nod-like receptor (NLR) signaling pathway; Transcriptional activation by NRF2 in response to phytochemicals; VEGFA-VEGFR2 signaling pathway; Neovascularisation processes; NRF2-ARE regulation; Neural crest cell migration during development; Neural crest cell migration in cancer","EPHB-mediated forward signaling; L1CAM interactions; EPH-ephrin mediated repulsion of cells; Ephrin signaling","Axon guidance",1.032,1.119,0.878,0.985,0.947,1,1,1,1,1,103.9,112.6,88.4,100.7,99.2,95.3,85.9,100.8,121.2,117.2,101.4,109.3,85.8,94.2,70.3,87.8,97.7,107.7,126.4,93.9,96.3,84.4,127.3,92.5,27.4,32.2,38.7,37.4,32.3,34.9,27.4,30,22.4,28,31.2,34.3,40.3,30,30.7,26.9,40.6,29.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UJJ9","N-acetylglucosamine-1-phosphotransferase subunit gamma [OS=Homo sapiens]",9,2,4,2,305,34,6.95,8.6,"other metabolic processes","other membranes;ER/Golgi","other molecular function","GNPTG","ENSG00000090581","","","Lysosome",1.033,1.128,1.059,1.136,1.035,1,1,1,1,1,97,105.9,99.4,93.9,106.7,97.2,119,90.8,94.4,104.9,99.1,103,89.4,110.9,96.7,89.2,91.4,95.1,96.7,103.8,106.5,94.6,120.7,93.8,66.3,50.6,52.6,58.4,55.2,57.4,49.8,61.8,53.9,49.7,50.9,53,53.9,57.9,59.4,52.7,67.3,52.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q16822-1","Phosphoenolpyruvate carboxykinase [GTP], mitochondrial [OS=Homo sapiens]",38,19,49,19,640,70.7,7.62,111.26,"other metabolic processes","","kinase activity;other molecular function","PCK2","","","","",1.034,1.055,1.053,1.021,1.012,1,1,1,1,1,100.5,102.5,102.3,97.2,99.2,98.4,100.7,102,100.6,104.8,102.8,100.5,104.6,98,102.6,97,101.8,97.4,100.1,99.4,97.3,98.6,91.9,99.7,1525.7,1545.9,1523.8,1587.7,1557.5,1522.9,1585.2,1484.8,1553.9,1469.6,1541.8,1475.8,1517.2,1506.3,1474,1493.8,1392.5,1510.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NXE4-2","Isoform 2 of Sphingomyelin phosphodiesterase 4 [OS=Homo sapiens]",26,19,47,19,798,90.1,7.97,84.1,"","","","","","","","",1.035,1.078,1.065,1.052,0.961,1,0.896216369758551,1,1,1,100.3,104.5,103.2,96.9,101.9,93.1,98.9,108.1,100.1,106.9,104.3,103.4,94.8,104.6,103.1,93.1,99.1,96.8,101.8,100,102.9,93,90.1,99,1802,1969.7,1825.4,1948.2,1901.8,1885.7,1728.4,1906.8,1879.1,1696.8,1806.5,1763.7,1855.5,1823.7,1875.7,1695.1,1642.6,1805.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q13535","serine/threonine-protein kinase ATR [OS=Homo sapiens]",9,18,27,18,2644,301.2,7.43,64.68,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;kinase activity;other molecular function","ATR","ENSG00000175054","miRNA regulation of DNA damage response; Cell cycle; ATR signaling; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; NIPBL role in DNA damage - Cornelia de Lange syndrome; DNA damage response","Regulation of HSF1-mediated heat shock response; TP53 Regulates Transcription of DNA Repair Genes; Meiotic synapsis; Fanconi Anemia Pathway; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","Fanconi anemia pathway; Cell cycle; p53 signaling pathway; Cellular senescence; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection",1.037,1.031,0.987,0.943,0.962,1,1,1,0.412758178653043,0.646936110000824,104.4,103.8,99.4,100.7,94.9,96.9,105.8,102.1,103.3,106.6,100.7,102.7,97.4,98.8,98.3,99.6,99.4,113.5,93,93.9,96.4,95.8,100,92.7,647.8,625.5,632.7,652.8,616.7,628.8,596.9,605.3,602.2,610.1,609.2,695.5,569.4,575.4,590.6,586.9,612.6,567.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UBS8-1","e3 ubiquitin-protein ligase rnf14 [OS=Homo sapiens]",7,3,4,3,474,53.8,4.75,6.97,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","RNF14","ENSG00000013561","Androgen receptor signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation","",1.038,0.953,0.925,0.915,0.857,1,1,1,1,1,109.5,100.5,97.5,105.5,96.6,90.4,119.2,87.7,108.8,92,109.7,99.8,95.3,96.9,115.2,98.3,113.3,104.8,91.5,97.7,95.9,84.1,89.8,99.9,152.7,112.4,139.3,117.8,140.5,127.9,122,124.1,147.5,125.9,145.1,134.2,117.2,125.2,122.8,107.7,115,127.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NR45","sialic acid synthase [OS=Homo sapiens]",49,13,69,13,359,40.3,6.74,117.51,"other metabolic processes","cytosol;other cell component","other molecular function","NANS","ENSG00000095380","","Sialic acid metabolism","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",1.039,1.076,1.079,1.071,1.072,1,0.175453549790111,0.0504860694856347,0.100887102231572,0.101113382471687,98.4,101.8,102.1,94.7,101.4,101.5,100.7,95.5,98.2,99.2,101.7,103.1,101,102,104.5,94.5,94.5,97.1,100.8,102,101.2,102.5,101.3,100.1,1922.3,1823.3,1874.8,1892.7,1940.2,1968.5,1927.7,1946,1995.4,1803.6,1802.8,1853.1,1924.4,1947.2,1931.9,1956.6,1933.9,1910.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O00764-1","Pyridoxal kinase [OS=Homo sapiens]",40,11,42,11,312,35.1,6.13,76.73,"other metabolic processes","non-structural extracellular;nucleus;other cell component","kinase activity;other molecular function","HEL-S-1a; PDXK","ENSG00000160209","","Neutrophil degranulation; Vitamins B6 activation to pyridoxal phosphate","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors",1.042,1.038,1.023,1.026,1.095,1,1,1,1,1,100.4,100.1,98.7,96.4,98.9,105.5,103.2,102.5,100.3,102.1,100.8,102.2,105.5,87.9,100.6,101.5,98.3,97,100.8,105.7,100.9,108.3,74.6,107.7,1009.7,1001.9,981.4,998.2,985.8,999.1,1032.2,859.6,984.3,992.4,961.7,949.1,986,1033.6,986.9,1058.7,730,1052.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y4X5","E3 ubiquitin-protein ligase ARIH1 [OS=Homo sapiens]",37,15,42,15,557,64.1,5.08,85.92,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ARIH1","ENSG00000166233","","ISG15 antiviral mechanism","",1.043,1.057,1.026,1.053,1.048,1,1,1,1,0.34765979120106,100.5,101.9,98.9,96.4,101.4,101,102.8,99,99.7,98.3,101.1,103.2,98.1,98,99.1,96,94,95.6,102.7,100.7,98.8,100.2,113.3,99.2,1529.8,1473.4,1483.2,1462.4,1504.1,1534.4,1459.7,1457.5,1474.7,1428.7,1398.7,1422.7,1528.1,1497.6,1469.6,1490.5,1685.3,1475.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96KP4","cytosolic non-specific dipeptidase [OS=Homo sapiens]",57,20,121,20,475,52.8,5.97,241.18,"protein metabolism","cytosol;nucleus","other molecular function","CNDP2","ENSG00000133313","","Glutathione synthesis and recycling","Arginine and proline metabolism; Histidine metabolism; beta-Alanine metabolism; Metabolic pathways",1.044,1.03,1.02,1.024,1.022,1,1,1,1,1,102,100.7,99.6,97.7,100.1,99.8,102.5,102.1,99.9,100.7,101.2,100.8,99.7,100.4,98.5,97.8,97.6,101.5,100.2,97.6,102,99.9,96.1,101.3,4241.9,4227.8,4136.8,4169,4189.8,4173,4128.8,4158.1,4079.3,4049.8,4041.6,4201.4,4148.6,4038.8,4222.9,4137.7,3980.1,4194.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P19838","Nuclear factor NF-kappa-B p105 subunit [OS=Homo sapiens]",7,3,3,3,968,105.3,5.4,9.6,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","NFKB1","ENSG00000109320","Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; PDGF pathway; Apoptosis; T cell receptor and co-stimulatory signaling; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Apoptosis-related network due to altered Notch3 in ovarian cancer; IL1 and megakaryocytes in obesity; Myometrial relaxation and contraction pathways; Melatonin metabolism and effects; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; NAD metabolism, sirtuins and aging; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; MYD88 distinct input-output pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Oxidative damage response; IL-4 signaling pathway; Prion disease pathway; NO/cGMP/PKG mediated neuroprotection; Oxidative stress response; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Non-genomic actions of 1,25 dihydroxyvitamin D3; Ciliary landscape; Nonalcoholic fatty liver disease; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Canonical NF-kB pathway; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Aspirin and miRNAs; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; FGF23 signaling in hypophosphatemic rickets and related disorders; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; Activation of NLRP3 inflammasome by SARS-CoV-2; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; STING pathway in Kawasaki-like disease and COVID-19; RAS and bradykinin pathways in COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Neuroinflammation and glutamatergic signaling; Malignant pleural mesothelioma; Prostaglandin signaling; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Inclusion body myositis; Alzheimer's disease; TGF-beta receptor signaling; Notch signaling pathway; T-cell receptor (TCR) signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway; Toll-like receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; Neutrophil degranulation; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; DEx/H-box helicases activate type I IFN and inflammatory cytokines production","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; HIF-1 signaling pathway; Sphingolipid signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Cellular senescence; Osteoclast differentiation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Prolactin signaling pathway; Adipocytokine signaling pathway; Relaxin signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Alcoholic liver disease; Alzheimer disease; Pathways of neurodegeneration; Cocaine addiction; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Amoebiasis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Transcriptional misregulation in cancer; Viral carcinogenesis; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Inflammatory bowel disease; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",1.046,0.887,1.156,0.999,1.091,1,1,1,1,1,101.6,86.1,112.2,97.1,97,106,93.6,113,98.1,80.7,103.6,83.2,108.4,111.4,101.9,90.6,93.8,128.2,73.8,93.7,113.7,95.9,102.4,114.1,18.4,22.2,19.3,15.8,20.3,16.3,21.3,21.9,20,17.8,18.4,25.1,14.5,18.4,22.3,18.8,20.1,22.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P27144","Adenylate kinase 4, mitochondrial [OS=Homo sapiens]",64,11,66,11,223,25.3,8.4,142.85,"other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion;other cell component","kinase activity;other molecular function","AK4","ENSG00000162433","CCL18 signaling pathway","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors",1.048,1.033,1.009,1.04,1.031,1,1,1,1,1,102,100.6,98.3,97.4,101.3,100.4,100.5,101.8,103.4,99.5,104,100.3,98,102.3,97.7,95.1,100.4,97.1,101,104.6,101,100.1,92.7,100.5,2781.2,2817.4,2863.5,2755.1,2878.8,2777.6,2712.8,2833.5,2704.5,2633.4,2778.2,2688.6,2796.1,2896.4,2796.5,2772,2565.3,2782.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8N3C0","Activating signal cointegrator 1 complex subunit 3 [OS=Homo sapiens]",8,14,19,14,2202,251.3,7.09,32.53,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","other molecular function","ASCC3","ENSG00000112249","Mesodermal commitment pathway; VEGFA-VEGFR2 signaling pathway","ALKBH3 mediated reversal of alkylation damage","",1.049,1.071,1.056,1.133,1.068,0.613685887369939,0.515549357941287,0.530912564901554,0.0125665996888925,0.327250340561129,98.7,100.7,99.4,94.1,106.6,100.5,98.6,104.7,94.4,101.8,100.6,98.9,99.3,102.5,97.7,91.4,94.8,94,109.3,104.5,106.5,100.5,100.4,100,851.9,905,815.7,879.9,869.7,854.5,858.2,886,844.4,790.2,819.1,812.3,944.6,903.4,920.2,868.1,867.5,864.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UL15-1","BAG family molecular chaperone regulator 5 [OS=Homo sapiens]",27,9,18,9,447,51.2,6.05,33.98,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","BAG5","ENSG00000166170","","Regulation of HSF1-mediated heat shock response","",1.051,1.123,1.064,1.067,1.141,1,1,1,1,0.699615158954765,97.8,104.5,99,93.1,99.3,106.2,97.4,93.2,101.5,104.3,97.3,104,98.5,104,97.7,92.6,92.6,98.4,102.3,93.9,98.8,105.7,122.9,94.9,492,470.9,512.7,526.9,491.5,525.5,497.9,525.2,493.4,468.1,467.7,497.3,516.8,474.3,499.4,534.2,621,479.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P42766","60S ribosomal protein L35 [OS=Homo sapiens]",28,4,9,4,123,14.5,11.05,7.27,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPL35","ENSG00000136942","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",1.053,1.146,1.153,1.205,1.094,1,1,1,0.290388401153205,1,95,103.4,104,90.2,108.7,98.7,89,95.6,104.3,104.7,104.1,90.6,104.7,99.5,108.1,94.6,90.8,90.3,109.4,123.3,102.7,99.3,88.8,100.5,836,898.4,979.9,983.8,978.1,851,983.6,934.6,1016.1,889.1,853.2,848.6,1027.9,1158.7,965.2,933.4,834,944,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y4P8-6","Isoform 6 of WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",24,6,9,1,443,48.2,6.3,21.67,"","","","WIPI2","","","","",1.054,1.015,0.914,0.962,1.111,1,1,1,1,1,104.4,100.6,90.5,99.1,95.3,110.1,98.7,112.4,83.6,126.7,95.1,83.4,145.4,67.9,85.6,93.7,99.4,93.3,94.1,90.1,88.9,152.3,85.4,104.1,24.8,28.3,21,31.9,23.9,21,36.6,17.1,21.5,23.6,25,23.5,23.7,22.7,22.4,38.3,21.5,26.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NZJ5","Eukaryotic translation initiation factor 2-alpha kinase 3 [OS=Homo sapiens]",14,10,17,10,1116,125.1,5.43,43.91,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","EIF2AK3","ENSG00000172071","Translation factors; Alzheimer's disease and miRNA effects; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; 7q11.23 copy number variation syndrome; Alzheimer's disease","Signaling by ALK fusions and activated point mutants; ALK mutants bind TKIs; PERK regulates gene expression","Mitophagy; Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Hepatitis C; Measles; Herpes simplex virus 1 infection; Lipid and atherosclerosis",1.057,1.078,1.171,1.132,1.097,0.641213916863137,0.662032970715644,0.060567430686127,0.2979239603715,0.312776665581419,97,98.9,107.5,91.8,103.9,100.8,97.5,102.5,97.4,99.5,98.7,103,102.5,109.8,108.1,87.2,92.9,92.3,94,106.6,104.5,97.4,104.7,101.3,617.2,648.9,616.3,629.4,624.6,651.7,648.7,694.9,684,552,588.1,584.2,594.7,674.9,661.3,616.3,662.8,641.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P35579-1","Myosin-9 [OS=Homo sapiens]",58,117,578,92,1960,226.4,5.6,1378.08,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","MYH9","ENSG00000100345; ENSPTRG00000014309","Primary focal segmental glomerulosclerosis (FSGS); VEGFA-VEGFR2 signaling pathway; Nephrotic syndrome","Signaling by ALK fusions and activated point mutants; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases activate CIT; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; CD163 mediating an anti-inflammatory response","Vascular smooth muscle contraction; Tight junction; Regulation of actin cytoskeleton; Pathogenic Escherichia coli infection",1.059,1.018,0.97,1.026,1.108,1,1,1,1,0.715519477410772,102.8,98.8,94.2,97.1,99.6,107.5,106.7,101.2,104.1,90.2,100.1,100.2,95.4,99.7,95.1,98.3,95.1,98.4,102.2,88.9,100.8,108.9,115.1,99.9,20347.2,19288.2,19844.8,17202.1,19085.4,19098,18186.9,18999.8,18128.5,18745.1,18126.4,18755.2,19477.5,16941.6,19225.8,20760.7,21945.1,19038.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O14562","Ubiquitin domain-containing protein UBFD1 [OS=Homo sapiens]",33,7,35,7,309,33.4,5.77,62.32,"","","","UBFD1","ENSG00000103353","","","",1.06,1.12,1.109,1.151,0.972,1,1,1,1,1,99.1,104.8,103.7,93.6,107.7,91,98.5,91.8,107.1,115,104.1,94,103,103.9,96.4,111.6,92.9,92.9,110,107,99.4,76.3,105.7,90.4,1324.6,1234.2,1440.5,1546.4,1400.5,1264,1386.2,1397.8,1297.2,1501.6,1249,1250.2,1480,1439.4,1337.5,1026.1,1421.8,1215.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O75832","26S proteasome non-ATPase regulatory subunit 10 [OS=Homo sapiens]",52,10,64,10,226,24.4,6.1,103.3,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PSMD10","ENSG00000101843","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway","Degradation of DVL; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","",1.061,1,1.015,1.033,1.033,1,1,1,1,1,103.7,97.6,99.2,97.7,100.9,100.9,103.8,106.5,102.3,103.5,97.7,96,99.2,106,96.3,97.8,96.2,98.4,100.8,101.6,101,89.2,102.8,101,2307.4,2368.3,2274.9,2302.3,2173.1,2135.5,2207.1,2357,2140.7,2173.9,2139.3,2187.8,2241.6,2258.9,2246.2,1983,2287,2245.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q7Z7H5","Transmembrane emp24 domain-containing protein 4 [OS=Homo sapiens]",34,7,49,5,227,25.9,8.28,112.09,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED4","ENSG00000158604","","","",1.064,1.005,0.989,1.027,0.979,1,1,1,1,0.86270837017514,105.2,99.4,97.9,98.9,101.7,96.8,105,106.6,106.6,100.7,97.6,104.7,99.1,96.3,100.7,100.2,106.3,99.8,99.6,102.9,103,98,73.2,99.6,793,804.9,804.6,760.3,736.8,790.8,748.2,727.4,760.5,756.4,803,753.8,752.3,777.1,777.8,740.4,552.9,752.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8N983","39S ribosomal protein L43, mitochondrial [OS=Homo sapiens]",10,2,5,2,215,23.4,8.65,3.24,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL43","ENSG00000055950","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1.064,0.938,1.03,0.96,0.925,1,1,1,1,1,107.9,95.1,104.5,101.4,97.3,93.7,109.1,98.9,114.4,100.9,96.2,94.4,105.6,106.7,96.3,107.3,102.5,91.1,98.4,110.5,87.8,94.8,76.2,108.7,159.5,144.5,167.1,147.5,140.6,138,154.4,155.8,140.8,156.8,149.8,133.1,143.8,161.5,128.3,138.5,111.4,158.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O75165","DnaJ homolog subfamily C member 13 [OS=Homo sapiens]",14,25,39,25,2243,254.3,6.74,89.93,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","DNAJC13","ENSG00000138246","","Neutrophil degranulation","",1.067,1.019,1.052,1.021,1.024,1,1,1,1,1,103.5,98.9,102.1,97.1,99.1,99.4,105.3,104.2,97.2,99.5,98.5,101.2,102.7,100.5,104.1,93.7,103.4,97.7,99.6,104.1,99.7,100,84.5,104.1,1596.7,1579.3,1473.4,1508.8,1492.5,1534.1,1557.4,1523.3,1577.8,1419.7,1567.1,1480.7,1509.2,1578.5,1511.2,1515.7,1281.6,1578.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P22570","NADPH:adrenodoxin oxidoreductase, mitochondrial [OS=Homo sapiens]",22,9,25,9,491,53.8,8.44,44.68,"other metabolic processes","other membranes;mitochondrion","other molecular function","FDXR","ENSG00000161513","","Pregnenolone biosynthesis; Endogenous sterols; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin","",1.068,1.148,1.161,1.115,1.142,0.330383904082268,0.00847756636086712,3.11217200993576E-3,0.0162229177094869,1.88128559134268E-3,96.6,103.8,105,90.4,100.8,103.3,96.4,96.6,95.2,102.5,103.9,103.6,106.7,104.7,102.3,89.6,91.1,90.2,100.6,98.4,103.4,103.1,110.4,101.3,1027.4,1029.9,1014.8,1093,1108,1103.9,1136.9,1116.1,1091,955.2,970.6,961.6,1072,1049.3,1102.6,1098.6,1176.3,1080.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q92783","signal transducing adapter molecule 1 [OS=Homo sapiens]",24,8,18,7,540,59.1,4.82,44.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","STAM","ENSG00000136738","Vitamin D receptor pathway; VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway","Cargo recognition for clathrin-mediated endocytosis; RHOU GTPase cycle; Endosomal Sorting Complex Required For Transport (ESCRT); Metalloprotease DUBs; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell","Endocytosis; JAK-STAT signaling pathway",1.07,1.143,1.125,1.15,1.131,1,0.508132667226285,0.736168646246449,0.212417171870881,0.152539560219037,97,103.6,102,90.7,104.2,102.5,96.1,94.4,99.2,100.6,104.4,102.6,97.2,103.2,101,99.7,89.8,86.8,102.7,105.5,103.2,110.7,101.6,101.4,545.2,535.4,562.8,570.8,592.2,582.4,551.4,585.5,573.3,565.5,509.6,492.8,582.9,598.5,585.8,628.4,576.4,575.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8TBP0","TBC1 domain family member 16 [OS=Homo sapiens]",11,5,5,5,767,86.3,5.82,8.62,"transport;other biological processes","cytosol;other cytoplasmic organelle","enzyme regulator activity","TBC1D16","ENSG00000167291","","TBC/RABGAPs","",1.071,1.032,1.066,1.135,1.026,1,1,1,1,1,101.5,97.8,101,94.8,107.6,97.3,84.7,114.5,101.7,90.5,97.9,107,101.2,90.7,108.4,91.4,94.9,105.3,114.2,107.8,103.8,100.6,87.9,97.4,115.2,155.8,138.3,123.1,133.2,145.5,137.6,123.4,147.5,124.3,129.1,143.2,155.3,146.6,141.3,136.9,119.6,132.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8IVT5-1","kinase suppressor of Ras 1 [OS=Homo sapiens]",6,4,5,4,923,102.1,8.66,4.63,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","KSR1","ENSG00000141068","TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Clear cell renal cell carcinoma pathways; Ras signaling; MAPK pathway in congenital thyroid cancer","Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; RAF activation; Negative regulation of MAPK pathway","Ras signaling pathway; C-type lectin receptor signaling pathway; Tuberculosis",1.074,1.009,1.049,1.062,1.009,1,1,1,1,1,103.9,97.6,101.5,96.7,102.7,97.6,96.7,106.3,103.3,95.3,97.1,112.7,99.3,101,121.5,98.4,96.2,88.7,103.9,101,102.2,97.1,73,106.1,334.7,368.1,357.6,329.8,336.2,390.2,343.8,349.5,420.7,340.6,333.1,306.9,359.5,349.5,353.7,336.1,252.8,367.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NQX3","Gephyrin [OS=Homo sapiens]",15,9,17,9,736,79.7,5.43,41.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","GPHN","ENSG00000171723","Splicing factor NOVA regulated synaptic proteins; GABA receptor signaling; Fragile X syndrome","Molybdenum cofactor biosynthesis","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; GABAergic synapse",1.075,1.061,1.031,1.053,1.085,1,1,1,1,0.54747855202163,102.3,100.9,98.1,95.2,100.2,103.3,102.6,97,103.6,101.1,103.6,97,97.5,98.4,101.3,99.2,93,95.4,98.7,104,100.4,104.4,99.2,103.5,953.9,902.2,963.9,940.7,963.7,902.4,906.9,914.7,942.3,923.1,865.3,887,917.9,967.2,933.9,970.7,922.8,962.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O43169","Cytochrome b5 type B [OS=Homo sapiens]",64,6,33,6,146,16.3,4.97,87.14,"","other membranes","other molecular function","","","","","",1.077,1.049,1.14,1.087,1.036,1,1,1,1,1,101.1,98.5,107,93.9,102.1,97.3,88.4,110.1,101.7,102.5,94.2,99.1,94.3,107.7,110.7,94.1,111.4,94.5,97,106.5,102.7,82,97.9,105.1,872.9,1087.8,1005.2,1012.9,930.8,979.2,931.9,1063.8,1093.9,929.5,1100.5,933.6,958.1,1052.5,1015.2,810.6,967.4,1038.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P68371","Tubulin beta-4B chain [OS=Homo sapiens]",73,30,1773,1,445,49.8,4.89,3160.13,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response","non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","TUBB4B","ENSG00000188229","Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","Neutrophil degranulation; MHC class II antigen presentation; COPI-mediated anterograde transport; HCMV Early Events; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Formation of tubulin folding intermediates by CCT/TriC; Prefoldin mediated transfer of substrate  to CCT/TriC; COPI-dependent Golgi-to-ER retrograde traffic; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Recycling pathway of L1; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; The role of GTSE1 in G2/M progression after G2 checkpoint; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Post-chaperonin tubulin folding pathway; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Hedgehog 'off' state","Phagosome; Gap junction; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Salmonella infection",1.079,1.096,1.106,1.139,1.181,0.615258926246903,0.515549357941287,0.206270888731571,0.0745618341357776,6.35562418514441E-3,98.1,99.6,100.5,90.9,103.5,107.4,96.7,96.1,99.1,101.5,97.6,98.1,99,105.2,98.6,89.5,88.4,90.4,102,101.4,105.4,105.8,120.4,104.6,52098.9,51784.5,53425.3,54706.4,52626.3,52887,53367.7,56687.1,53153,48264.1,47649.1,48737.8,54976.6,54664.4,56806.6,57017.7,64909.4,56387.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q15121","Astrocytic phosphoprotein PEA-15 [OS=Homo sapiens]",8,1,1,1,130,15,5.02,2.31,"transport;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus","","PEA15","ENSG00000162734","Apoptosis modulation and signaling","RAF/MAP kinase cascade; RAF-independent MAPK1/3 activation","",1.082,1.097,0.969,1.054,1.056,1,1,1,1,1,103.7,105.2,92.9,95.9,101,101.2,102.8,99.7,112.8,104.1,115.1,104.3,97.7,92.1,88.6,103.9,87.3,95,99.2,109.8,100.1,82.7,104.4,100.3,103.3,100.2,113.4,104.7,115.7,104.8,98.2,92.6,89.1,104.5,87.7,95.5,99.7,110.4,100.7,83.1,104.9,100.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P22314","Ubiquitin-like modifier-activating enzyme 1 [OS=Homo sapiens]",65,57,535,56,1058,117.8,5.76,1255.54,"protein metabolism;other metabolic processes;stress response","cytosol;mitochondrion;nucleus;other cell component","other molecular function","UBA1","ENSG00000130985","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration",1.083,1.092,1.094,1.098,1.145,1.00860276128546E-3,0.000760570595858068,0.000710330040684339,0.000340050386200999,2.63445139042549e-05,99.8,100.6,100.8,92.1,101.2,105.5,100.6,99.2,99.9,100.7,100.5,102.3,101.5,99.9,100.8,92.2,91.9,92.9,101.2,100.6,102.1,105.6,106.2,101.9,20634.8,20347.7,20486.9,20657.9,20625.9,20980.5,20835.3,20503.2,20689.4,18916.2,18864.7,19053.8,20769.2,20636.1,20943.8,21667.1,21790.6,20914.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P50851-2","Isoform 2 of Lipopolysaccharide-responsive and beige-like anchor protein [OS=Homo sapiens]",19,35,58,1,2851,317.5,5.57,112.75,"","","","LRBA","","","","",1.085,1.691,1.138,1.197,1.414,1,1,1,1,0.660867702860427,86.5,134.8,90.7,79.7,95.5,112.7,78.1,68.6,95.7,119.9,121.8,121.7,76.6,138.1,81.9,85.8,72,63.8,86.2,81.6,127.1,92.2,187.2,101.7,18.7,16.4,22.9,28.7,29.2,29.1,18.3,33,19.6,20.5,17.2,15.3,20.6,19.5,30.4,22.1,44.8,24.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q00536-1","Cyclin-dependent kinase 16 [OS=Homo sapiens]",13,5,7,3,496,55.7,7.62,13.41,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","CDK16","ENSG00000102225; ENSMMUG00000014002; ENSPPAG00000031958; ENSPPYG00000020289; ENSRROG00000041471","","","",1.086,1.058,1.018,1.138,0.984,1,1,1,1,1,103.7,101,97.2,95.5,108.6,94,107.7,92.2,103.4,102.7,100.7,99,104.1,92,96.9,110.1,86.9,95.2,96.3,114.4,108.3,104.8,91.7,93.7,99.8,85.4,95.8,95.1,93.3,91.8,96.5,85.3,89.8,102,80.5,88.2,89.3,106,100.3,97.1,84.9,86.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P60468","protein transport protein Sec61 subunit beta [OS=Homo sapiens]",33,4,16,4,96,10,11.56,29.1,"protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;ER/Golgi","translation activity;other molecular function","SEC61B","ENSG00000106803","","ER-Phagosome pathway; SRP-dependent cotranslational protein targeting to membrane; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection",1.09,1.167,1.035,1.02,1.029,0.687027442454823,0.241471810829567,1,1,1,103.1,110.4,98,94.6,96.5,97.4,102.3,99.5,107.5,110.6,103.3,109.5,96,97.2,100.4,96.9,93.9,92.9,93.6,106.2,95.7,96.6,102.4,95.7,1229.3,1195.7,1291.7,1329.3,1241.7,1316.6,1154.4,1168.2,1207.4,1165,1128.3,1117.3,1124.9,1276.3,1150.4,1161,1231.1,1149.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UQ88-1","Cyclin-dependent kinase 11A [OS=Homo sapiens]",19,19,35,1,783,91.3,5.36,46.58,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","CDK11A","ENSG00000008128","","Recruitment of mitotic centrosome proteins and complexes","",1.092,1.051,1.059,1.067,1.021,1,1,1,1,1,104.1,100.3,101,95.4,101.8,97.4,103.4,104.9,96.8,105.5,99.6,95.9,105,100.3,91.8,89.1,94.8,103.7,101.1,93.8,112.8,96.8,113.1,91.6,174.8,177.3,163.5,178.2,168.3,162.1,177.4,169.5,155.1,150.5,160.1,175.1,170.8,158.4,190.6,163.5,191.1,154.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P62854","40S ribosomal protein S26 [OS=Homo sapiens]",21,2,9,2,115,13,11,21.29,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPS26","ENSG00000197728","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",1.093,1.078,1.064,1.291,0.851,1,1,1,0.831004720851052,1,102.8,101.4,100.2,94.1,121.4,80.1,88.5,104.5,102.7,106.9,101.3,88.6,100,100.1,123.1,94,94.2,79.7,121.3,151.3,104,80,56.6,103,238.4,281.6,276.8,288.1,273,238.7,269.5,269.6,331.8,253.3,253.7,214.7,326.9,407.7,280.1,215.6,152.4,277.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96S15-2","Isoform 2 of GATOR complex protein WDR24 [OS=Homo sapiens]",10,7,8,7,790,88.2,6.52,16.64,"other metabolic processes;stress response;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","WDR24","ENSG00000127580; ENSPPAG00000030128; ENSPTRG00000007554","","Amino acids regulate mTORC1","mTOR signaling pathway",1.095,1.093,1.067,1.058,1.129,1,0.891330451000955,1,1,0.396592102745332,101.9,101.8,99.4,93.1,98.6,105.2,102.3,94.7,102.5,108.8,102.2,99.8,99.7,104.5,94.7,98.1,93.5,92.1,100.3,93.8,98.9,100.5,107.9,105.5,340.2,315.1,341,361.8,339.9,332,331.6,347.7,314.9,326.2,310.8,306.2,333.7,312,329,334.3,358.9,351,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9ULJ6-1","Zinc finger MIZ domain-containing protein 1 [OS=Homo sapiens]",6,5,6,5,1067,115.4,7.46,10.29,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","ZMIZ1","ENSG00000108175","Androgen receptor signaling pathway; Androgen receptor signaling pathway","","",1.099,1.097,1.027,1.115,1.114,1,1,1,1,1,102.2,102.1,95.5,93,103.7,103.6,99.9,113,104.6,104.4,102.5,111.6,102.5,82.1,97.7,94.9,95.2,98.8,106.1,112.2,103.2,106,56.3,108.9,289.7,327.6,303.1,302.8,297.2,323.7,297,237.9,283.3,275.1,275.9,286.5,307.6,325.3,299.3,307.3,163.3,315.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","B0YJ81","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 [OS=Homo sapiens]",4,1,1,1,288,32.4,9.04,2.63,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","HACD1","ENSG00000165996","","Synthesis of very long-chain fatty acyl-CoAs","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism",1.1,1.059,1.061,1.033,1.055,1,1,1,1,1,104.7,100.7,100.9,95.1,98.3,100.4,117.7,101.2,99.2,114.2,92.4,97.4,97.6,113.3,95.2,84.1,92,101.4,95,120.7,93.5,84.6,97,103.3,43.3,37.2,36.5,42,34,35.8,35.9,41.7,35,31,33.8,37.3,35,44.4,34.4,31.1,35.7,38,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8N2F6-1","Armadillo repeat-containing protein 10 [OS=Homo sapiens]",17,4,6,4,343,37.5,6.61,13.58,"other biological processes","other membranes;mitochondrion;ER/Golgi","other molecular function","ARMC10","ENSG00000170632","","","",1.102,1.075,1.138,1.078,1.116,1,1,1,1,1,101.6,99.1,104.9,92.2,99.4,102.9,101.6,105,98.6,96.1,105.3,99,104.9,100.5,108.5,92,101.2,92.2,99.4,113.2,97.6,102.9,74.8,107.5,307.4,317.8,298.6,290.8,318.7,299.8,317.5,304.1,328.5,278.3,306.4,278.9,300.7,342.6,295.3,311.3,226.5,325.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q5MNZ6","WD repeat domain phosphoinositide-interacting protein 3 [OS=Homo sapiens]",4,1,4,1,344,38.1,7.59,5.52,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","WDR45B","ENSG00000141580","","Macroautophagy","",1.106,1.084,1.011,0.942,1.06,1,1,1,1,1,107,104.9,97.8,96.7,91.1,102.5,95.1,107,110.8,101.1,104.9,117.3,97.8,95.8,118.4,84.6,104.9,96.7,89.6,103.5,91.1,108.2,70.6,102.5,47.7,53.6,55.5,50.6,52.5,58.8,49,48,59.3,42.4,52.6,48.5,44.9,51.9,45.6,54.2,35.4,51.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q99633-1","Pre-mRNA-splicing factor 18 [OS=Homo sapiens]",30,7,19,7,342,39.8,8.15,25.59,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","","Prpf18; PRPF18","ENSCPOG00000021069; ENSG00000165630; ENSLAFG00000007753; ENSMFAG00000000540; ENSMMUG00000015071; ENSMNEG00000024679; ENSNLEG00000012186; ENSPPAG00000041959; ENSPTRG00000002306","mRNA processing; mRNA Processing","","Spliceosome",1.107,1.052,0.972,1.018,0.954,0.383968847263781,1,1,1,1,108.9,103.4,95.6,98.3,100,93.8,112.1,104.7,109.1,105.1,103.6,96.6,93.3,102.5,95.8,102.2,98.5,88.7,106.6,98.4,100.2,94,92.1,96.4,452.9,423.4,440.8,424.7,418.9,390.6,377.3,414.4,387,413.1,398.1,358.6,431,397.8,405,379.9,372.1,389.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O75531","Barrier-to-autointegration factor [OS=Homo sapiens]",25,3,5,3,89,10.1,6.09,2.34,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BANF1","ENSG00000175334","Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation","",1.109,1.098,1.025,1.139,0.956,1,1,1,1,1,105.2,104.1,97.2,94.8,108,90.7,107.5,92,104.2,127.5,103.1,83.4,96.3,86.9,100.4,122.8,84.8,93.9,77.8,127.5,107,89.8,88.5,106.4,150.6,128.8,145.9,178.5,144.4,116.7,134.9,121.7,140.5,172,118.7,131.5,108.9,178.6,149.9,125.8,123.9,149,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96GD4","Aurora kinase B [OS=Homo sapiens]",28,8,18,7,344,39.3,9.29,30.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AURKB","ENSG00000178999","Microtubule cytoskeleton regulation; ATM signaling in development and disease","APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Regulation of TP53 Activity through Phosphorylation; RHO GTPases Activate Formins; Regulation of MECP2 expression and activity; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; SUMOylation of DNA replication proteins","",1.113,1.032,1.156,1.191,1.231,0.150095860319815,1,0.0585515102471199,0.0227663704711503,0.00539250973134423,99.3,92.1,103.1,89.3,106.3,109.8,99.5,103.4,98.9,93.7,92.3,87.3,108.6,103.3,99.2,93.4,89.4,85.9,100.5,109.5,106.5,108,110.7,110,417.1,433.5,414.6,392.8,386.9,365.9,455.3,433.1,415.8,391.7,374.8,360.1,421.3,459.2,446.6,452.6,463.9,461.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P57060","RWD domain-containing protein 2B [OS=Homo sapiens]",5,1,1,1,319,36.3,5.87,4.78,"","","","RWDD2B","ENSG00000156253","","","",1.116,1.28,1.175,1.199,1.153,1,1,1,1,1,96.7,110.9,101.8,86.7,104,99.9,111.4,98,95.5,113.3,101.5,112.5,103.2,98.4,105.1,78.3,87.9,97.6,105.4,109,101.8,101.3,73.2,106.7,75.9,66.8,65,77.2,69.2,76.6,70.3,67,71.5,53.4,59.8,66.5,71.8,74.2,69.3,69,49.8,72.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8NB91","Fanconi anemia group B protein [OS=Homo sapiens]",2,2,2,2,859,97.7,7.61,4.73,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus","","FANCB","ENSG00000181544","DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",1.117,1.013,0.998,1.093,0.878,1,1,1,1,0.845135984576042,109.9,99.6,98.2,98.4,107.5,86.4,110.4,118.7,104.8,84.5,102.8,100.1,98.7,93.6,126.3,98.8,115.8,88.3,108,135.7,92.2,86.8,46.9,87.6,132.9,142.9,126.1,101.7,123.7,120.5,118.7,112.7,152,118.9,139.3,106.2,130,163.2,111,104.4,56.5,105.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NVJ2","ADP-ribosylation factor-like protein 8B [OS=Homo sapiens]",31,5,15,2,186,21.5,8.43,45.32,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","ARL8B","ENSG00000134108","Ciliary landscape","","Salmonella infection",1.121,1.143,1.188,1.151,1.159,0.760116047767338,1,0.33061644606686,0.563681108905363,0.711659325656818,99.5,101.4,105.4,88.7,102.1,102.8,100,101.3,100.9,103.6,102.9,96.7,111.3,106.9,98.5,90,94.8,84.3,94.8,108.8,103.6,91.6,104.3,105.7,377.7,382.7,381.4,391.5,388.7,365.4,420.6,403.9,372.1,340.1,358,318.6,358.2,411.1,391.5,346.2,394.1,399.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9BYD3","39S ribosomal protein L4, mitochondrial [OS=Homo sapiens]",34,6,10,6,311,34.9,9.72,21.07,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL4","ENSG00000105364","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",1.126,1.034,1.063,1.118,1.011,1,1,1,1,1,106.3,97.7,100.4,94.5,105.6,95.5,102.2,111,108.5,88.9,99.7,103.7,102.4,91.5,111.7,87.1,107.8,96.4,107.7,112.4,95.6,98.6,77.3,97.5,626.7,680.7,665.1,544.7,611,635.9,627.9,561,684.5,534.1,660.6,590.9,660.5,689.4,585.9,604.3,474.1,597.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q14197","Peptidyl-tRNA hydrolase ICT1, mitochondrial [OS=Homo sapiens]",17,3,3,3,206,23.6,10.07,2.99,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL58","ENSG00000167862","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1.128,1.014,0.856,1.1,0.887,1,1,1,1,1,113.1,101.7,85.8,100.3,110.3,88.9,102.6,108.6,112.4,107.7,97.6,91.3,82.4,118.1,64.2,125.4,96.3,90.8,129,87.7,105.9,67.1,127.6,85.4,26.3,27.9,28.8,27.6,25.1,23.4,21.1,30.3,16.5,32.2,24.7,23.3,33.1,22.5,27.2,17.2,32.7,21.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O75808-1","Calpain-15 [OS=Homo sapiens]",9,5,5,5,1086,117.2,6.71,12.48,"protein metabolism","other cell component","other molecular function","CAPN15","ENSG00000103326","","Degradation of the extracellular matrix","",1.133,1.136,1.182,1.25,1.299,1,1,1,0.732737481420799,0.0767481295329963,97.1,97.4,101.3,85.7,107.1,111.4,97.2,93.9,104.1,92.6,97.5,102.5,101.7,101.4,94,85.8,85.4,88.3,107.2,88.6,111.5,111.5,132,104.6,201.6,194.8,215.8,192.1,202.1,212.6,210.9,210.3,194.9,177.9,177,183.1,222.3,183.7,231.3,231.2,273.7,216.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P23786","Carnitine O-palmitoyltransferase 2, mitochondrial [OS=Homo sapiens]",44,23,67,23,658,73.7,8.18,143.51,"other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","CPT2","ENSG00000157184","Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Thermogenesis","PPARA activates gene expression; Carnitine metabolism","Fatty acid degradation; Fatty acid metabolism; PPAR signaling pathway; Thermogenesis; Diabetic cardiomyopathy",1.136,1.129,1.121,1.068,1.093,0.0019221137998191,0.00856948957572323,0.00677685993805065,0.0766687038251292,0.0810384420213622,104.1,103.5,102.7,91.6,97.9,100.2,106.6,103.2,104.4,105.7,101.2,103.7,102.8,103.7,103,89.4,91.9,91.9,97.8,100.4,98.1,100.5,94.1,101.7,3020.9,2924.1,2957.8,2993.7,2866.3,2938.9,2912.2,2937.5,2916.8,2532.8,2604.2,2602.9,2770.7,2844.4,2779.8,2846.1,2666.6,2880.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","A5A3E0","POTE ankyrin domain family member F [OS=Homo sapiens]",11,10,366,1,1075,121.4,6.2,713.12,"","other cell component","","POTEF","ENSG00000196604","","","",1.137,1.203,1.176,1.143,1.075,1,1,1,0.946403808999521,1,101.3,107.2,104.8,89.1,101.8,95.7,84.3,100.6,115,106.4,106.9,103,98.7,104,109.3,80,93.1,88.4,93.1,123.5,101.1,95,106.9,90.7,30.2,36.1,41.2,38.2,38.3,36.9,35.4,37.3,39.2,28.7,33.4,31.7,33.4,44.3,36.2,34.1,38.3,32.5,"Not Found","Not Found","Not Found","Not Found","Not Found","Not Found","Not Found","Not Found","Not Found","Not Found","Not Found","Not Found","Not Found","Not Found","Not Found","Not Found","Not Found","Not Found",1]
["High","Q9UN79","Transcription factor SOX-13 [OS=Homo sapiens]",3,2,3,2,622,69.2,6.71,1.72,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SOX13","ENSG00000143842","","Deactivation of the beta-catenin transactivating complex","",1.141,1.159,0.956,1.02,1.127,1,1,1,1,1,106.9,108.6,89.6,93.7,95.6,105.6,108.3,92,109.2,98.8,122.4,110,95.3,75.4,90.8,120.5,91.8,94.9,114.1,96.9,90.5,117.3,64.9,107,47,39.9,47.4,42.9,53.1,47.7,41.4,32.7,39.4,52.3,39.9,41.2,49.5,42,39.3,50.9,28.2,46.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8N122","Regulatory-associated protein of mTOR [OS=Homo sapiens]",5,5,5,5,1335,148.9,6.89,7.64,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPTOR","ENSG00000141564","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; CAMKK2 pathway; Autophagy; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Interferon type I signaling pathways","TP53 Regulates Metabolic Genes; Macroautophagy; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation","Autophagy; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Thermogenesis; Insulin signaling pathway; Shigellosis; MicroRNAs in cancer",1.148,1.037,0.98,1.018,0.997,0.363885399042143,1,1,1,1,111.4,100.7,95.2,97.1,98.8,96.8,111.8,104.7,112.1,101.1,106.1,96.7,95.6,94.8,95.5,94.9,97.9,97.5,99.2,101.7,90.8,108.8,97.2,93.5,204.4,191.4,204.9,184.7,193.8,176.8,174.6,173.3,174.6,173.5,179,178.1,181.2,185.9,165.9,198.8,177.6,170.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P53367","Arfaptin-1 [OS=Homo sapiens]",54,16,45,1,373,41.7,6.7,91.35,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","ARFIP1","ENSG00000164144","","","",1.149,1.109,1.106,1.14,1.145,0.732639016377934,1,1,0.686518256988771,1,103.7,100.1,99.8,90.2,102.9,103.3,107.3,104.5,100.9,100.7,102.5,100.9,100.6,100.2,101,96.5,88.6,90.9,103.2,107.2,103.7,104.6,82.5,104.1,1633.2,1590.9,1535.4,1533.5,1560.9,1535.9,1531.5,1525.3,1537.1,1469.7,1349.3,1384.4,1570.2,1632.2,1578.3,1591.6,1256,1584.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P31937","3-hydroxyisobutyrate dehydrogenase, mitochondrial [OS=Homo sapiens]",34,8,20,8,336,35.3,8.13,33.46,"other metabolic processes","mitochondrion","other molecular function","HIBADH","ENSG00000106049","Amino acid metabolism","Branched-chain amino acid catabolism","Valine, leucine and isoleucine degradation; Metabolic pathways",1.155,1.125,1.09,1.066,1.025,0.00883305050941852,0.128218007369937,0.374273859310183,1,1,107.3,104.5,101.2,92.9,99,95.2,113.5,107,104.2,104.2,104.4,102.9,102.6,99.3,101,90.1,92.6,97.4,94.6,98.9,98.8,98.6,95,94.8,819.4,772.5,752.4,752.1,753.3,743,740.5,716.9,728.8,650.1,668.6,703.1,682.6,714,712.7,711.9,685.6,683.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8IYL2","probable tRNA (uracil-O(2)-)-methyltransferase [OS=Homo sapiens]",11,5,5,5,757,84.6,7.27,10.42,"RNA metabolism OR transcription;other metabolic processes","other cell component","other molecular function","TRMT44","ENSG00000155275","","tRNA modification in the nucleus and cytosol","",1.162,1.136,1.211,1.11,1.302,1,1,1,1,1,100.7,98.5,105,86.7,96.3,112.9,101.3,72.7,106.6,93.1,99,101.5,105.5,93.8,114.8,124.3,87.2,79.7,95.6,107.2,96.8,113.5,117.4,89.9,46.9,33.7,49.3,43.1,45.8,47,48.9,43.4,53.1,57.6,40.3,36.9,44.3,49.6,44.8,52.5,54.3,41.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8N128","Protein FAM177A1 [OS=Homo sapiens]",31,5,5,5,213,23.7,4.45,10.53,"","","","FAM177A1","ENSG00000151327","","","",1.166,1.085,1.093,1.089,1.101,1,1,1,1,1,107,99.6,100.4,91.8,100,101.1,109.3,99.8,113.8,101.7,106.7,101.3,102.5,89.9,105.4,83.6,95.9,93.7,99.5,109.4,102.1,107.9,74.5,103.2,332.5,303.7,346.2,309.5,324.6,308.2,311.8,273.7,320.7,254.5,292,285.3,302.9,333,310.7,328.4,226.9,314,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NWH2","Transmembrane protein 242 [OS=Homo sapiens]",9,1,1,1,141,14.7,9.11,2.39,"","other membranes","","TMEM242","ENSG00000215712","","","",1.168,1.055,1.069,1.157,1.168,1,1,1,1,1,105.9,95.7,96.9,90.7,105,105.9,104.3,96.1,109.1,103.8,94.3,88.7,108.7,95.5,92.5,86.1,89.3,93.3,93.1,103.4,110.2,104.3,78.4,148.8,28.8,26.5,30.1,28.6,26,24.5,30,26.3,25.5,23.8,24.7,25.8,25.7,28.5,30.4,28.8,21.6,41.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9HAW4","Claspin [OS=Homo sapiens]",15,13,19,13,1339,151,4.82,36.19,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","CLSPN","ENSG00000092853","","Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Ub-specific processing proteases; Apoptotic cleavage of cellular proteins","",1.174,1.067,1.015,1.107,1.148,0.085176665969481,1,1,0.368572440827056,0.161308814648841,108.2,98.3,93.5,92.1,102,105.8,109,103.1,111.4,92.5,105.3,99,99.7,93.9,94.2,94.8,80.9,92.8,102.8,99.8,104.7,106.6,108.6,100.6,699.7,662.1,715.2,593.9,676.3,635.9,640.4,602.9,604.9,608.7,519.3,596.1,660.1,640.9,672.3,684.4,697.6,645.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UQ03-1","Coronin-2B [OS=Homo sapiens]",9,4,5,4,480,54.9,8.27,14.85,"cell adhesion;cell organization and biogenesis;other biological processes","other membranes;cytoskeleton;other cell component","cytoskeletal activity","CORO2B","ENSG00000103647; ENSPTRG00000007218","","","",1.179,0.976,0.949,0.994,0.955,0.978693327858917,1,1,1,1,116.9,96.7,94,99.1,98.5,94.7,166,103.4,114.8,92.8,96.7,95,85.9,92.3,98.2,94.7,98.8,97.3,96.7,106.3,91.4,93,69.5,107.2,419,261,289.8,234.3,244.1,239.8,216.8,233.1,247.9,239.1,249.4,245.7,244.2,268.4,230.8,234.7,175.4,270.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8TCT7","signal peptide peptidase-like 2B [OS=Homo sapiens]",8,2,3,2,592,64.6,8.32,4.56,"protein metabolism;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","SPPL2B","ENSG00000005206","","Regulation of TNFR1 signaling","",1.181,1.227,1.205,1.46,1.582,1,1,1,1,0.634606046561916,92.6,96.2,94.5,78.4,114.4,124,90.1,146.8,84.8,93.6,103,78,91.9,117.1,90.4,94.7,71.4,76.3,114.6,73.4,111.3,120.6,135.3,106.6,12.3,20,11.6,12.8,14,10.6,12.5,16,12.3,12.9,9.7,10.4,15.6,10,15.2,16.4,18.4,14.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96BH1","E3 ubiquitin-protein ligase RNF25 [OS=Homo sapiens]",18,6,10,6,459,51.2,6.54,20.72,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","RNF25","ENSG00000163481","","Antigen processing: Ubiquitination & Proteasome degradation","",1.188,1.111,1.214,1.197,1.109,1,1,1,1,1,104.6,97.7,106.8,88,105.3,97.6,124.5,94.8,102,111.5,95.3,89.2,104.2,107.1,87.3,102.1,85.8,85.3,102.8,100,117,88.1,95.2,108,392.4,298.8,321.5,351.3,300.5,281.2,328.4,337.6,275,321.8,270.5,268.8,323.9,315.1,368.8,277.6,300,340.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9NYB0","Telomeric repeat-binding factor 2-interacting protein 1 [OS=Homo sapiens]",42,11,24,11,399,44.2,4.73,61.45,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TERF2IP","ENSG00000166848","Splicing factor NOVA regulated synaptic proteins","DNA Damage/Telomere Stress Induced Senescence; Meiotic synapsis; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; Polymerase switching on the C-strand of the telomere; Removal of the Flap Intermediate from the C-strand; Telomere C-strand synthesis initiation; Telomere Extension By Telomerase","",1.194,1.198,1.182,1.193,1.185,0.090325957235425,0.122822682850965,0.348892354761132,0.0589362201590897,0.249255742682394,103.1,103.4,102,86.3,102.9,102.3,103.8,100,106.9,103.8,104.1,105.9,104.9,91.8,102.8,89,86.9,84.4,109.1,102.7,103.7,106.3,90.9,103,1327.2,1278,1366.3,1327.2,1331.1,1353.5,1341.6,1173.9,1313.7,1137.9,1111.1,1078.3,1395,1313.1,1325.4,1359,1162.6,1316.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O60858","E3 ubiquitin-protein ligase TRIM13 [OS=Homo sapiens]",15,5,5,5,407,47,6.01,7.74,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","TRIM13","ENSG00000204977","","ER Quality Control Compartment (ERQC)","",1.197,1.155,1.093,1.246,1.157,1,1,1,1,1,104.9,101.2,95.8,87.6,109.1,101.4,109,105.2,110.2,105.3,105.2,101,99.5,101.8,96.8,96,86.1,91,118.3,113.4,80.5,110.8,64.5,105.3,74,71.4,74.9,71.5,71.4,68.6,67.6,69.1,65.8,65.2,58.5,61.8,80.3,77,54.7,75.3,43.8,71.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O60513","Beta-1,4-galactosyltransferase 4 [OS=Homo sapiens]",6,2,2,2,344,40,9.07,5.73,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B4GALT4","ENSG00000121578","","N-Glycan antennae elongation; Keratan sulfate biosynthesis","Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways",1.201,1.135,1.031,1.075,0.965,1,1,1,1,1,112.5,106.3,96.6,93.6,100.7,90.4,118.7,115.7,101.9,95.7,109.4,109.4,99.4,91.9,113.6,90.9,104,96.4,103.6,123.7,98,95.6,39.1,93,131.7,128.4,113.1,106.3,121.4,121.5,110.3,102.1,126,100.9,115.5,106.9,114.9,137.3,108.8,106.1,43.4,103.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UNE7-1","E3 ubiquitin-protein ligase CHIP [OS=Homo sapiens]",29,8,13,8,303,34.8,5.87,33.16,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","STUB1","ENSCATG00000030791; ENSCSAG00000012299; ENSG00000103266; ENSGGOG00000043504; ENSMFAG00000031388; ENSMNEG00000033024; ENSPPAG00000028029; ENSPPYG00000006921; ENSPTRG00000007553; ENSRBIG00000029383; ENSRROG00000037882","Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway; Androgen receptor signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Downregulation of TGF-beta receptor signaling","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",1.212,1.086,1.093,1.22,0.959,1,1,1,1,1,110.7,99.2,99.8,91.3,111.4,87.6,112.8,96,113.8,106,101,89.3,106.7,101.7,92.3,101.5,90.2,93,113.5,122,93.2,76.5,89.2,101.3,571,486,576,536.8,511.5,452.1,540.4,514.8,467.4,513.9,456.7,471,574.5,617.5,471.7,387.2,451.8,513,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q9BVN2","RUN and SH3 domain-containing protein 1 [OS=Homo sapiens]",1,1,1,1,902,96.4,6.3,0,"protein metabolism;other metabolic processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","RUSC1","ENSG00000160753","IL-18 signaling pathway","","",1.216,1.122,1.253,1.121,1.263,1,1,0.477664627699968,1,0.463801252767377,104.6,96.5,107.8,86,96.4,108.7,104.7,81.5,115.7,99.8,96.6,90.2,105.8,107.8,120.5,86.1,96,79.8,96.5,103.4,88.2,107,111.7,108.8,17.9,13.9,19.8,17.1,16.5,15.4,18.1,18.4,20.6,14.7,16.4,13.6,16.5,17.7,15.1,18.3,19.1,18.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q86UD0","Suppressor APC domain-containing protein 2 [OS=Homo sapiens]",3,1,1,1,394,42.6,8.82,1.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","","SAPCD2","ENSG00000186193","","","",1.223,0.957,0.977,0.955,1.094,1,1,1,1,1,118.2,92.6,94.5,96.7,92.3,105.7,112.4,87.5,122.9,84.3,88,118.3,123.8,89.9,88.5,108.6,82.5,92,85.7,87.8,127.3,100.6,93.4,106.6,26.8,20.8,29.3,20.1,21,28.2,29.5,21.4,21.1,25.9,19.6,21.9,20.4,20.9,30.3,23.9,22.2,25.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q16774-1","guanylate kinase [OS=Homo sapiens]",21,4,11,4,197,21.7,6.55,26.05,"other metabolic processes;transport","cytosol;other cell component","kinase activity;other molecular function","GUK1","ENSG00000143774","","Interconversion of nucleotide di- and triphosphates; Abacavir metabolism","Purine metabolism; Metabolic pathways",1.232,1.136,1.144,1.178,1.061,0.0940800014854075,0.402913037769302,0.438443661877646,0.175989305596689,1,109.5,101,101.7,88.9,104.7,94.3,115.6,97.2,109.2,110,100.7,99.2,98.9,105.3,101.4,91.4,88.6,84.5,106.9,103.1,104.4,94.1,88.5,101.3,839.4,705.8,793.3,799.3,731.6,720.4,718.2,765.1,736.6,663.7,643.8,613.6,776.8,748.7,758.4,683.2,642.6,735.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P24534","Elongation factor 1-beta [OS=Homo sapiens]",63,10,67,8,225,24.7,4.67,156.86,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","enzyme regulator activity;nucleic acid binding activity","EEF1B2","ENSG00000114942; ENSG00000283391","Translation factors","Eukaryotic Translation Elongation","",1.236,1.241,1.206,1.264,1.13,1,1,1,1,1,104.8,105.2,102.3,84.8,107.1,95.8,105.4,82.4,118.1,118.8,105.8,88.2,103.5,102.9,86.6,116,81.3,85.3,107.8,118.5,95.3,87.4,100.4,96.4,2457.9,1921.4,2755.2,2771,2468.3,2056.4,2413.8,2398.9,2018.8,2705.9,1896.1,1988.7,2513.1,2762.9,2223.6,2038.3,2342.1,2247.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O60331","Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [OS=Homo sapiens]",6,4,4,4,668,73.2,5.29,9.33,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIP5K1C","ENSG00000186111","B cell receptor signaling pathway; Focal adhesion; Regulation of actin cytoskeleton","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer",1.246,1.193,1.233,1.219,1.304,0.207112685355471,1,0.616423604090458,0.414757667713408,0.40145083560728,103.9,99.5,102.8,83.4,101.7,108.7,105.1,104.1,113,91.4,100.7,100.6,108,94.8,104,84.4,83.6,87.8,95.9,112.5,102.9,113.3,87.9,110,230.7,228.5,248.1,200.6,221,220.8,236.9,208,228.2,185.1,183.5,192.6,210.4,246.9,225.7,248.6,193,241.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q15048","Leucine-rich repeat-containing protein 14 [OS=Homo sapiens]",6,2,2,2,493,54.5,6.9,5.65,"other biological processes","other cell component","other molecular function","LRRC14","ENSG00000160959","","","",1.252,1.182,1.23,1.106,1.203,0.373036473609989,0.937675566630101,0.241977318093544,1,0.274324729466905,107.7,101.7,105.8,86.1,95.2,103.5,111.7,107,92.7,101,102.7,99.1,101.2,105.2,114,82.8,85.5,96,93.2,98.9,94.6,111.7,102.8,99.8,56.2,53.8,46.6,50.8,51.6,49.9,50.9,52.9,57.4,41.6,43,48.3,46.9,49.8,47.6,56.2,51.7,50.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q7Z2K8-1","G protein-regulated inducer of neurite outgrowth 1 [OS=Homo sapiens]",6,5,6,5,1008,102.3,8.06,11.61,"cell organization and biogenesis;developmental processes","plasma membrane;other membranes;other cell component","other molecular function","GPRIN1","ENSG00000169258","MECP2 and associated Rett syndrome","MECP2 regulates neuronal receptors and channels","",1.264,1.232,1.252,1.19,1.14,0.915706408997812,1,1,1,1,107.2,104.4,106.1,84.8,100.9,96.6,107.4,97.4,109.7,104.7,106.6,100.4,115.7,84.8,106.3,100.3,76.5,84.9,103.8,101.1,94.7,113.5,96.8,95.4,260,235.8,265.7,253.4,258.2,243.2,280.2,205.2,257.5,242.8,185.2,205.7,251.3,244.8,229.2,274.9,234.4,231,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q14376","UDP-glucose 4-epimerase [OS=Homo sapiens]",31,8,18,8,348,38.3,6.73,38.67,"other metabolic processes","cytosol","other molecular function","GALE","ENSG00000117308","","Galactose catabolism; Defective GALE can cause Epimerase-deficiency galactosemia (EDG)","Galactose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",1.282,1.203,1.185,1.353,1.3,0.0768582825526568,0.474159430278856,0.429855459077896,0.0266185546676184,0.133412380523753,105,98.6,97.1,81.9,110.9,106.5,111.6,101,104.7,98.3,95.7,103.5,96.8,93.7,104.7,80.9,81.7,82.4,110.5,117.9,106.4,116.1,88.1,106.2,583.4,528,547.4,513.8,500.6,541.1,506,490,547.5,423,426.9,430.7,577.7,616.4,556.3,607.3,460.8,555,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q70CQ4-1","Ubiquitin carboxyl-terminal hydrolase 31 [OS=Homo sapiens]",1,2,2,2,1352,146.6,9.22,2.03,"protein metabolism;other metabolic processes","nucleus","other molecular function","USP31","ENSG00000103404","","","",1.286,1.174,1.186,1.086,1.289,0.679706908947598,1,1,1,0.811467967146757,109.9,100.3,101.4,85.5,92.8,110.1,111.3,116.4,106,111.2,88.2,101.6,102.7,78.5,106.5,83.1,91.6,86.5,82.9,94,116.4,111.5,111.9,99.7,70.2,73.5,66.9,70.1,55.6,64.1,64.8,49.5,67.2,52.4,57.8,54.6,52.3,59.3,73.4,70.3,70.6,62.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q01628","Interferon-induced transmembrane protein 3 [OS=Homo sapiens]",31,2,9,2,133,14.6,7.01,50.24,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","","IFITM3","ENSG00000142089","Host-pathogen interaction of human coronaviruses - MAPK signaling; Network map of SARS-CoV-2 signaling pathway","Interferon alpha/beta signaling","",1.301,1.076,1.013,1.074,1.001,0.0879775069412201,1,1,1,1,120.8,99.8,94,92.8,99.7,92.9,123.9,109,119.5,108.3,98.4,98.8,93,91,108.5,96,85.5,91.8,97.8,100.1,98.6,84.4,91.9,103.5,291.3,256.1,280.8,254.5,231.3,232.1,218.5,213.9,255.1,225.5,201,215.8,230,235.1,231.8,198.3,216.1,243.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96RY5","Protein cramped-like [OS=Homo sapiens]",3,2,2,2,1269,134.6,7.87,7.78,"developmental processes","nucleus","nucleic acid binding activity;other molecular function","CRAMP1","ENSG00000007545","","","",1.326,0.975,1.059,0.984,1.073,0.14890113266096,1,1,1,1,124,91.1,99,93.5,92,100.3,111.6,127.9,124.4,98.7,83.2,91.4,99.3,101.1,91.7,98.6,83.4,93.8,108.9,92.3,86.3,94.2,100.7,112.5,74.4,85.3,83,65.8,55.4,61,66.2,67.4,61.2,65.7,55.6,62.5,72.6,61.5,57.5,62.8,67.1,75,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O96000","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [OS=Homo sapiens]",19,3,3,3,172,20.8,8.48,6.91,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB10","ENSG00000140990","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Modulators of TCR signaling and T cell activation; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",1.342,1.119,1.032,0.983,0.852,1,1,1,1,1,127.3,106.1,97.8,94.8,93.2,80.8,125.9,95.3,130.1,123.9,105,98.8,97.1,93.1,96.8,117,80.5,93.8,92.2,125,89.7,58.3,79.9,97.3,74.9,56.7,77.4,73.7,62.4,58.7,57.8,55.3,57.5,69.6,47.9,55.8,54.8,74.3,53.4,34.7,47.5,57.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9HBM0-1","vezatin [OS=Homo sapiens]",9,6,9,6,779,88.6,5.2,23.38,"cell adhesion","plasma membrane;other membranes;cytosol;nucleus;other cell component","cytoskeletal activity","VEZT","ENSG00000028203","","","",1.352,1.028,1.006,0.998,1.022,1.08794371588328E-3,1,1,1,1,126.6,96.3,94.2,93.6,93.5,95.7,135.8,127.1,116.5,96.6,96,98,93.9,94.5,99.8,94,94.8,93.3,93.8,89.1,96.2,96,88.2,96.2,580.8,543.4,498.3,413.2,410.3,418.8,401.5,404.3,426.7,401.8,405.5,398.9,401.1,380.9,411.5,410.7,377.1,411.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8WZ19","BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 [OS=Homo sapiens]",10,3,3,2,329,36.3,7.23,2.01,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","KCTD13","ENSG00000174943","16p11.2 proximal deletion syndrome","RND2 GTPase cycle; RND3 GTPase cycle","",1.393,1.276,1.266,1.436,1.406,0.793290333905073,1,1,0.970647201432852,0.869402102199436,107.5,98.5,97.6,77.2,110.7,108.5,115.5,109.5,103.7,85.1,105.5,100.3,110.7,78.7,99.5,90.4,76.2,78.6,117.2,112.8,92.7,131.9,81,110.6,132.1,125.2,118.5,97.3,120.6,114.7,126.5,89.9,113.7,103.3,87.1,89.8,133.9,129,105.9,150.7,92.6,126.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P54803","Galactocerebrosidase [OS=Homo sapiens]",5,2,2,2,685,77,6.64,6.58,"other metabolic processes;developmental processes","other cytoplasmic organelle","other molecular function","GALC","ENSG00000054983","","Glycosphingolipid metabolism","Sphingolipid metabolism; Metabolic pathways; Lysosome",1.431,1.02,1.093,0.989,1.101,0.232533942776612,1,1,1,1,129.4,92.2,98.8,90.4,89.5,99.6,145,128.5,105,106.5,82.5,91.6,98.1,99.8,90,89.8,93.5,87.6,88.8,116.2,86.8,98.9,91.7,99.8,88.2,78.2,63.9,64.8,50.2,55.7,59.7,60.7,54.8,54.6,56.9,53.3,54,70.7,52.8,60.2,55.8,60.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8NFQ8","Torsin-1A-interacting protein 2 [OS=Homo sapiens]",36,13,27,12,470,51.2,4.96,61.31,"cell organization and biogenesis;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","TOR1AIP2","ENSG00000169905","","","",1.444,1.405,1.505,1.437,1.619,0.00414648005109688,0.0112881142846408,1.77590283699815E-3,2.09042971402197E-3,0.000261654679210008,103,100.2,107.4,71.3,102.5,115.5,103.7,94.2,103.2,101.3,100.4,96.7,107.5,111.3,102.8,74.6,67.8,71.4,102.6,101.3,109.5,115.7,131,104.9,1406.7,1278.3,1399.9,1374.9,1362,1312.6,1459.1,1510.4,1395.4,1011.6,919.8,969.4,1392.6,1375.2,1486,1569.4,1778.2,1422.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q92968","Peroxisomal membrane protein pex13 [OS=Homo sapiens]",11,3,3,3,403,44.1,8.05,0,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","PEX13","ENSG00000162928","","Peroxisomal protein import; Class I peroxisomal membrane protein import; E3 ubiquitin ligases ubiquitinate target proteins","Peroxisome",1.506,1.505,1.579,1.545,1.403,0.0980971714001304,0.177710654868043,0.195264526232442,0.0473386611020407,0.55817251788918,105.8,105.8,111,70.3,108.6,98.6,96.2,107,121.2,107,115.3,100.3,112.2,113.2,88.8,64.2,71.1,78.7,126.6,109.8,108.6,104.5,99.7,75.5,19,21.1,23.9,21.1,22.7,19.8,22.1,22.3,17.5,12.7,14,15.5,25,21.6,21.4,20.6,19.7,14.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q08AF3-1","schlafen family member 5 [OS=Homo sapiens]",3,2,2,2,891,101,8.22,4.52,"other biological processes","nucleus","other molecular function","SLFN5","ENSG00000166750","","","",1.564,1.458,1.565,1.652,1.538,0.00325630115866773,0.0203314542645118,0.00216817995869471,9.39776798212774E-4,0.0010991433579256,106.9,99.7,107,68.4,112.9,105.1,111.2,105.6,92.5,94.5,98.4,98.5,105.7,101.5,118.5,67.5,66.8,70,109.9,115,111.5,103.7,125.4,103.8,83,78.9,69.1,70.6,73.5,73.6,78.9,75.8,88.5,50.4,49.9,52.3,82.1,85.9,83.3,77.4,93.6,77.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O95295","SNARE-associated protein Snapin [OS=Homo sapiens]",14,2,4,2,136,14.9,9.31,7.34,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SNAPIN","ENSG00000143553","","Golgi Associated Vesicle Biogenesis","",1.644,1.3,1.248,1.178,1.057,0.435355992159459,1,1,1,1,132.8,105,100.8,80.8,95.2,85.4,135.5,101.6,139.6,107.2,108.1,87.6,113.3,102.9,78.9,91.8,76.4,82.4,97.1,117.3,95.5,68.1,87.1,109.7,127.9,96,131.9,101.2,102,82.7,107,97.1,74.5,86.7,72.1,77.8,91.7,110.7,90.2,64.3,82.2,103.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P07197","Neurofilament medium polypeptide [OS=Homo sapiens]",43,36,115,33,916,102.4,4.91,227.22,"cell organization and biogenesis","cytoskeleton;other cell component","cytoskeletal activity","NEFM","ENSG00000104722","Amyotrophic lateral sclerosis (ALS); Physico-chemical features and toxicity-associated pathways; Ciliary landscape","","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",1.869,1.452,1.777,2.684,3.161,5.07995546554045e-07,8.0578903571922e-05,1.84310801680322E-6,1.14292677174295E-8,3.90734019214041e-09,93.9,72.9,89.3,50.2,134.9,158.8,94.7,90.9,96.8,68.6,73.5,73.5,86.7,90.8,90,52.5,49,50.6,138.7,135.9,132.6,163.7,151.4,160.1,3665.2,3520.2,3747,2655.9,2846.2,2846.7,3355.7,3516.9,3484.3,2032.4,1897,1960.5,5369.8,5262.8,5133.4,6337.3,5861,6196.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9Y240","C-type lectin domain family 11 member A [OS=Homo sapiens]",3,1,1,1,323,35.7,5.16,3.03,"signal transduction;other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;other molecular function","CLEC11A","ENSG00000105472","","","",2.147,1.155,1.148,1.184,1.192,0.000891898354982089,1,1,1,0.588535400056929,164.6,88.5,88,76.7,90.8,91.4,219.1,154.2,159.7,91.4,85.9,74.5,84.7,85.4,96.1,74.6,67.1,74.4,92.4,88.1,68.1,88.6,107.7,88,136.2,95.9,99.3,56.8,53.4,46.3,52.7,53.1,59.8,46.4,41.7,46.3,57.4,54.8,42.3,55.1,66.9,54.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O95754-1","Semaphorin-4F [OS=Homo sapiens]",2,1,2,1,770,83.5,6.95,5.43,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","SEMA4F","ENSG00000135622","","RND3 GTPase cycle","Axon guidance",2.206,1.379,1.364,1.378,1.182,1.05723336542371E-3,0.723144232037058,0.268754255789904,0.479213774359981,0.869049252303865,155.6,97.2,96.2,70.5,97.2,83.4,169.6,145,154.6,104.7,96.6,79.1,95.6,110.4,92.8,68.5,71.7,70.1,96.6,101.1,82.2,105.4,73.2,82.9,55.1,47.1,50.2,34,31.4,25.7,31,35.9,30.2,22.2,23.3,22.8,31.4,32.8,26.7,34.2,23.8,26.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H8G1","Zinc finger protein 430 [OS=Homo sapiens]",15,3,7,1,570,66.3,8.65,5.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF430","ENSG00000118620","","Generic Transcription Pathway","Herpes simplex virus 1 infection",2.208,1.226,1.395,1.323,1.531,0.000562612933583849,0.692195233747138,0.0619105652617401,0.108211146603351,0.0273181794595873,152.6,84.7,96.4,69.1,91.4,105.8,162.5,152.3,153.2,93.1,70.4,85,95.1,109.5,96.8,45.4,69.4,69.6,91.8,86,103.6,101.9,108.1,106.2,37.6,35.3,35.5,21.6,16.3,19.7,22,25.4,22.4,10.5,16.1,16.1,21.3,19.9,24,23.6,25,24.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q99757","Thioredoxin, mitochondrial [OS=Homo sapiens]",6,1,1,1,166,18.4,8.29,3,"other metabolic processes;stress response;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","TXN2","ENSG00000100348","Oxidative stress response","Detoxification of Reactive Oxygen Species; Degradation of cysteine and homocysteine","NOD-like receptor signaling pathway; Parkinson disease; Salmonella infection; Fluid shear stress and atherosclerosis",2.226,1.685,1.234,1.136,1.402,1,1,1,1,1,153.8,116.4,85.2,69.1,78.5,96.9,161.4,68.6,158.3,119.8,120.8,85.4,116.5,36.9,87.7,189.8,59.9,71.1,80.8,138.6,73.5,113.8,17.5,99.7,74.5,31.7,73.1,55.3,55.8,39.4,53.8,17,40.5,87.6,27.6,32.8,37.3,64,33.9,52.5,8.1,46,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q969R5-1","Lethal(3)malignant brain tumor-like protein 2 [OS=Homo sapiens]",8,5,9,3,705,79.1,6.84,15.26,"cell organization and biogenesis;other biological processes","nucleus","other molecular function","L3MBTL2","ENSG00000100395","","SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6","",2.234,0.866,0.946,0.94,1.034,1.69517899899779E-3,1,1,1,1,191,74,80.8,85.5,80.3,88.3,233,187.7,185.4,82,72.7,70.2,75.2,79.4,92.4,86.6,79.8,84,76.5,81.3,78.9,86.8,55.8,92.3,488.5,393.4,388.7,171.9,152.5,147.2,157.6,166.5,193.6,181.5,167.4,176.1,160.3,170.4,165.5,182,116.9,193.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O00622","Protein CYR61 [OS=Homo sapiens]",23,8,17,8,381,42,8.21,29.16,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi","signal transduction activity or receptor binding;other molecular function","CCN1","ENSG00000142871","Oncostatin M signaling pathway; VEGFA-VEGFR2 signaling pathway; Hypertrophy model","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",2.237,1.374,1.787,2.648,3.232,6.54466735527937e-07,0.00247897870258712,8.39569075939816e-06,2.74677821228882E-8,6.7116044203767e-09,109.3,67.2,87.3,48.9,129.4,158,112.5,105,109.1,69.1,67,65.3,87.1,87,90.5,47.9,48.8,52.5,129.1,138.7,125.6,162.9,144.3,157.6,946.9,883.7,917.9,581.3,563.9,549.4,733.2,732.5,761.8,403,410.3,441.8,1086.6,1167.3,1057.5,1370.9,1214.2,1326.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","P51884","Lumican [OS=Homo sapiens]",2,1,1,1,338,38.4,6.61,0,"cell organization and biogenesis;developmental processes;other biological processes","extracellular matrix;ER/Golgi;other cytoplasmic organelle","extracellular structural activity;other molecular function","LUM","ENSG00000139329","","Integrin cell surface interactions; ECM proteoglycans; Keratan sulfate biosynthesis; Keratan sulfate degradation; Defective CHST6 causes MCDC1; Defective ST3GAL3 causes MCT12 and EIEE15; Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)","Proteoglycans in cancer",2.239,0.78,0.779,0.879,0.885,0.0702966574922808,1,1,1,1,204.7,71.3,71.3,91.4,80.3,80.9,409.9,175.8,171.1,88,46.2,61.2,70.6,61.2,51.8,78.5,52.2,85.1,52,69,110.4,61.9,69.5,85.5,222.1,95.3,92.7,47.7,25,33.2,38.2,33.2,28.1,42.5,28.3,46.1,28.2,37.4,59.8,33.5,37.7,46.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","P32248","C-C chemokine receptor type 7 [OS=Homo sapiens]",2,1,1,1,378,42.8,8.48,0,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","other molecular function","CCR7","ENSG00000126353","Peptide GPCRs; Chemokine signaling pathway; Selective expression of chemokine receptors during T-cell polarization; Leukocyte-intrinsic Hippo pathway functions; GPCRs, class A rhodopsin-like","G alpha (i) signalling events; Chemokine receptors bind chemokines","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; Chemokine signaling pathway",2.241,1.586,1.747,3.287,4.541,0.019309564467571,0.976683975791957,0.103812043583361,0.00073754790227358,9.15067355895137E-5,93.4,66.1,72.8,41.7,136.9,189.2,104.7,73.4,94.8,71.9,67,49.4,71.7,89.5,73.9,54.5,39,42.3,139,147.9,125.6,162.1,201.3,192,108.7,76.1,98.3,74.7,69.6,51.2,74.4,92.9,76.7,56.5,40.5,43.9,144.2,153.5,130.4,168.2,208.9,199.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q6QNY1","biogenesis of lysosome-related organelles complex 1 subunit 2 [OS=Homo sapiens]",21,1,1,1,142,16,4.86,3.66,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","BLOC1S2","ENSG00000196072","","","",2.259,1.821,1.842,2.155,1.936,0.970943977219113,1,1,1,1,123.1,99.2,100.4,54.5,117.4,105.5,118.7,110.9,111.1,169.8,89.6,88.4,146.5,90.6,82.6,100.8,49.2,48.1,130.7,106,77.4,55.2,129.4,95.2,21.1,19.7,19.8,30.2,15.9,15.7,26.1,16.1,14.7,17.9,8.7,8.5,23.3,18.9,13.8,9.8,23,16.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P69905","Hemoglobin subunit alpha [OS=Homo sapiens]",17,2,22,2,142,15.2,8.68,43.54,"other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;translational apparatus;other cell component","other molecular function","HBA1; HBA2","ENSG00000188536; ENSG00000206172","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Effects of nitric oxide","Scavenging of heme from plasma; Heme signaling; Cytoprotection by HMOX1; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","African trypanosomiasis; Malaria",2.28,1.038,1.076,1.241,1.397,1.11946632202249e-05,1,1,0.0570916375452767,0.0219034580028065,170.3,77.5,80.4,74.7,92.7,104.4,195.8,166.7,167.3,82.1,69.8,76.2,77.3,79,84.1,66.5,73.4,76,90.5,104.4,91.1,103.7,93.4,102.5,1533.8,1306.2,1310.9,643.3,546.5,596.9,605.6,619,659.1,520.9,575,595.5,709.3,818.2,713.6,812.4,732,803.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P49918","cyclin-dependent kinase inhibitor 1C [OS=Homo sapiens]",27,6,12,6,316,32.2,5.52,33.02,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","CDKN1C","ENSG00000129757","Cell cycle; Primary focal segmental glomerulosclerosis (FSGS); Dopaminergic neurogenesis; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Oxidative damage response; G1 to S cell cycle control; Small cell lung cancer; Endochondral ossification; Endochondral ossification with skeletal dysplasias; 7q11.23 copy number variation syndrome; Galanin receptor pathway","Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)","Cell cycle",2.35,2.459,2.451,2.237,2.173,1.75323658596689e-05,2.30917216781985E-5,1.01709400839986e-05,2.30856556998966e-05,2.32427434642172e-05,111.3,116.4,116.1,47.4,106,102.9,116.1,101.6,110.8,116,118,104.6,137.9,115.6,106,48.9,45.6,47.2,104.1,106.9,105.5,102.5,111.8,100.9,583.3,510.3,556.6,582.5,592.8,525.6,692.7,580.6,532.5,245.8,228.8,236.9,523.1,537.2,530.1,514.7,561.7,507,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P07996","thrombospondin-1 [OS=Homo sapiens]",14,12,14,11,1170,129.3,4.94,26.4,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","THBS1","ENSG00000137801","Complement system; Bladder cancer; Apoptosis-related network due to altered Notch3 in ovarian cancer; miRNA targets in ECM and membrane receptors; Focal adhesion; TGF-beta signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; p53 transcriptional gene network; TGF-beta receptor signaling","RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins; Signaling by PDGF; Integrin cell surface interactions; Platelet degranulation ; Syndecan interactions","Rap1 signaling pathway; p53 signaling pathway; Phagosome; PI3K-Akt signaling pathway; TGF-beta signaling pathway; Focal adhesion; ECM-receptor interaction; Malaria; Human papillomavirus infection; Proteoglycans in cancer; MicroRNAs in cancer; Bladder cancer",2.355,1.235,1.317,1.666,1.863,7.80384723551532e-06,0.189220637327521,0.0291339592025572,0.000567499977779891,4.39547661844123e-05,149.8,78.5,83.8,63.6,105.9,118.4,166.8,139.6,146.3,79,76.2,76.7,81.7,86.7,81.8,64.6,56.9,62.1,103.5,104.6,101.9,115.7,141.3,114.6,598.4,501,524.8,283.5,273.2,275.2,293.1,311.2,293.5,231.7,204.2,222.8,371.2,375.3,365.5,415,506.9,411.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P02042","Hemoglobin subunit delta [OS=Homo sapiens]",13,2,12,2,147,16,8.05,25.21,"other metabolic processes;transport;other biological processes","cytosol;other cell component","other molecular function","HBD","ENSG00000223609","VEGFA-VEGFR2 signaling pathway","Factors involved in megakaryocyte development and platelet production","",2.369,1.188,1.267,1.516,1.464,2.36876286818187E-4,1,1,0.128638572573418,0.288914172014583,161.4,81,86.4,68.2,103.3,99.8,212.3,149.6,157.6,81.9,79,68.2,84.3,86.7,80,65.2,66.5,81.6,100.9,101.4,100.6,100.3,86.4,97.4,997,702.7,740.1,384.8,371.1,320.2,395.9,407,375.8,306.1,312.5,383,473.6,476,472.2,470.8,405.8,457.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9H3M7","thioredoxin-interacting protein [OS=Homo sapiens]",44,12,28,12,391,43.6,7.5,58.92,"cell cycle OR cell proliferation;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","TXNIP","ENSG00000265972","VEGFA-VEGFR2 signaling pathway; Unfolded protein response","Cytoprotection by HMOX1; Regulation of FOXO transcriptional activity by acetylation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection","NOD-like receptor signaling pathway",2.369,2.452,2.719,2.156,2.085,4.64935061970157e-06,9.78548562735604e-06,2.61761335720404e-06,6.66697206147048e-06,2.11739488924558e-05,111.2,115.1,127.6,46.9,101.2,97.9,111.1,118.4,110.8,115,113.3,117.8,127.5,120.2,128.1,46.2,46.9,47,99.8,101.1,114.2,103.1,81.8,97.7,1121.6,1195.8,1118.9,1160.8,1143.9,1189,1287.2,1213.3,1293.7,466.9,473.4,474.8,1008.2,1020.8,1153.5,1041.1,826.4,987,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","P83369","U7 snRNA-associated Sm-like protein LSm11 [OS=Homo sapiens]",3,1,1,1,360,39.5,10.99,2.63,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","LSM11","ENSG00000155858","","RNA Polymerase II Transcription Termination; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","",2.476,0.731,0.979,0.989,1.031,0.0870995361490959,1,1,1,1,206.1,60.8,81.5,83.3,82.4,85.9,245.4,204.6,191.5,94.5,59.9,60.4,82.2,80.9,58.2,84.7,74.6,82.6,82.7,81.8,49.3,85.2,131.3,50.3,80.2,66.9,62.6,30.9,19.6,19.7,26.9,26.4,19,27.7,24.4,27,27,26.7,16.1,27.8,42.9,16.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P27986","Phosphatidylinositol 3-kinase regulatory subunit alpha [OS=Homo sapiens]",7,3,6,3,724,83.5,6.16,8.25,"cell adhesion;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R1","ENSG00000145675","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; Role of LAT2/NTAL/LAB on calcium mobilization; Interleukin-4 and Interleukin-13 signaling; RHOC GTPase cycle; RHOB GTPase cycle; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; RHOJ GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; Role of phospholipids in phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Downstream TCR signaling; RND2 GTPase cycle; G alpha (q) signalling events; RHOD GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; Signaling by FGFR3 fusions in cancer; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",2.491,1.076,1.197,1.126,1.064,0.152746335181125,1,1,1,1,187.9,81.2,90.3,75.4,84.9,80.3,210.1,172,144.2,86.9,66.4,74.3,126.7,82.7,69.1,59.6,69.1,74.2,68.6,78.8,77.7,73.5,198.5,67.7,354.6,290.2,243.3,146.6,112,125.4,213.7,139.5,116.5,100.6,116.5,125.1,115.8,133,131.1,124,334.8,114.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O15240","Neurosecretory protein VGF [OS=Homo sapiens]",29,17,38,17,615,67.2,4.78,79.58,"cell-cell signaling;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;ER/Golgi;other cell component","signal transduction activity or receptor binding","VGF","ENSG00000128564","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; NGF-stimulated transcription","",2.502,1.337,1.886,4.309,4.808,0.0142912710856668,1,0.0612917815787908,0.000262123970096884,0.000155406512786515,94.8,50.6,71.4,37.9,163.2,182.1,95.1,72.5,93,49.7,56.2,44,68.7,86,70.1,39.8,37.2,32,222.9,160.2,132.4,137,224.7,178.7,898.5,684.8,878.7,469.6,530.8,415.5,649.2,812.7,662.2,375.9,351.2,302,2106.4,1513.3,1250.7,1294,2122.7,1688.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9HBL0","Tensin-1 [OS=Homo sapiens]",2,2,2,1,1735,185.6,7.75,0,"","cytoskeleton;other cell component","cytoskeletal activity","TNS1","ENSG00000079308","Integrin-mediated cell adhesion","","",2.527,1.146,1.065,0.958,1.292,0.509158568793407,1,1,1,1,189.9,86,80,75.1,72,97,206.1,157.6,147.7,126.1,61.4,71.4,228.3,60.8,66.4,62.6,45.5,62.4,59.8,72.8,41,80.5,198.1,51.5,129.9,99.4,93.1,79.5,38.7,45,143.9,38.3,41.9,39.5,28.7,39.3,37.7,45.9,25.8,50.8,124.9,32.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q86TM6","E3 ubiquitin-protein ligase synoviolin [OS=Homo sapiens]",8,4,9,4,617,67.6,6.95,9.07,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","SYVN1","ENSG00000162298","","Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; XBP1(S) activates chaperone genes; ER Quality Control Compartment (ERQC)","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",2.561,1.086,1.073,1.021,1.081,3.42430608072887e-05,1,1,1,1,196.5,83.3,82.3,76.7,78.3,82.9,251.3,190.1,179.5,88.7,78.7,80.6,79.6,78.7,83,74.2,69.3,75.2,65.9,85,75.8,85.2,78.9,80.2,898.8,679.8,642.1,317.3,281.6,288.2,284.8,281.5,296.9,265.5,247.9,268.9,235.8,303.9,271.1,304.7,282.1,286.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8WTW3","conserved oligomeric Golgi complex subunit 1 [OS=Homo sapiens]",10,7,9,7,980,108.9,7.31,16.65,"cell organization and biogenesis;transport","other membranes;ER/Golgi","","COG1","ENSG00000166685","","COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic","",2.587,1.118,1.101,1.101,1.105,2.60852386968755E-5,1,1,1,0.784478236954982,193.7,83.7,82.5,74.9,82.4,82.7,247.8,179.2,187.1,88.3,80.9,79.7,74.2,79.7,79.8,65.8,73,72.3,74.1,85.6,79.6,94.6,79.9,78.6,885.8,640.7,669,315.5,289.2,284.8,265.2,284.8,285.3,235.2,260.9,258.6,264.8,306.1,284.6,338.1,285.6,281.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P04114","apolipoprotein B-100 [OS=Homo sapiens]",2,8,20,8,4563,515.3,7.05,40.67,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","APOB","ENSG00000084674","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Statin inhibition of cholesterol production; Male infertility; Familial hyperlipidemia type 2","Heme signaling; Cell surface interactions at the vascular wall; Scavenging by Class B Receptors; Regulation of TLR by endogenous ligand; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; VLDL assembly; VLDL clearance; Scavenging by Class F Receptors; Scavenging by Class H Receptors; Platelet sensitization by LDL; LDL remodeling","Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; Lipid and atherosclerosis",2.656,1.002,1.017,1.227,1.109,0.00388275478774267,1,1,1,1,198.9,75.1,76.2,74.9,91.9,83,140.8,264.4,196.2,83.1,74,70.3,70.8,75.1,83.1,71.5,73.9,74.8,77,107.2,90.6,81.9,68.5,96.5,1516.8,2847.2,2113.3,895.2,797.4,757.5,762.6,809.3,894.6,769.8,795.7,806.1,829.4,1154,976.2,882.3,738.2,1039.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P04004","Vitronectin [OS=Homo sapiens]",9,2,16,2,478,54.3,5.8,26.76,"cell adhesion;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;extracellular structural activity;other molecular function","VTN","ENSG00000109072","Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; Inflammatory response pathway; Complement system in neuronal development and plasticity","ECM proteoglycans; Regulation of Complement cascade; Integrin cell surface interactions; Syndecan interactions; Molecules associated with elastic fibres","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Complement and coagulation cascades; Human papillomavirus infection; Proteoglycans in cancer",2.704,1.214,1.495,1.361,1.616,0.000376214846227121,1,0.560650279096094,0.482769649230107,0.0624883574733962,172.8,77.6,95.5,63.9,86.9,103.2,195.6,170.3,147.5,82.5,73.4,76.5,94.2,76.2,98,62.5,63,74.8,81.7,100.3,85.7,92.1,124.1,101.8,323.1,281.3,243.6,136.3,121.2,126.3,155.6,125.8,161.8,103.2,104,123.6,134.9,165.6,141.6,152.2,205,168.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q4G0I0","protein CCSMST1 [OS=Homo sapiens]",9,1,1,1,132,15,7.02,0,"","other membranes","","CCSMST1","ENSG00000174109","","","",2.721,0.974,0.949,0.951,0.878,1.23496311668224E-3,1,1,1,1,218.5,78.2,76.2,80.3,76.4,70.5,272.8,214.2,214.9,76.9,80.5,68.7,93.2,62.6,75,79,52.5,87.1,66.7,77.9,75.1,80.2,53.4,69.4,78.9,61.9,62.1,22.2,23.3,19.9,26.9,18.1,21.7,22.8,15.2,25.2,19.3,22.5,21.7,23.2,15.4,20.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P35555","Fibrillin-1 [OS=Homo sapiens]",3,8,10,5,2871,312,4.93,18.2,"","extracellular matrix","extracellular structural activity;other molecular function","","","","","",2.779,1.319,1.153,1.13,1.339,2.6749709228298e-05,1,1,1,0.355703250198154,191.2,90.8,79.3,68.8,77.8,92.1,226.7,169.4,192.1,91.2,74.7,92.7,77.4,86.9,79.7,74.9,68.6,69.1,78.1,78.6,70.1,92.6,94.2,82.8,259.4,193.8,219.7,104.3,85.4,106.1,88.6,99.4,91.2,85.7,78.5,79.1,89.4,89.9,80.2,105.9,107.8,94.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q96RW7-1","Hemicentin-1 [OS=Homo sapiens]",1,3,3,3,5635,613,6.49,4.34,"cell adhesion;cell cycle OR cell proliferation;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","HMCN1","ENSG00000143341","","","",2.793,0.942,0.872,0.835,0.888,2.90259971381512E-5,1,1,1,1,228.6,77.1,71.4,81.9,68.4,72.7,265.7,221.1,218.7,76.4,73.9,74.6,76.2,68.6,69,79.2,69.9,82.3,60.5,80.1,66.1,83.7,63.7,70.3,288.6,240,237.5,83,80.3,81,82.7,74.4,75,86,75.9,89.4,65.7,87,71.8,90.9,69.2,76.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P52895","Aldo-keto reductase family 1 member C2 [OS=Homo sapiens]",3,1,1,1,323,36.7,7.49,3.39,"other metabolic processes;signal transduction;other biological processes","cytosol","other molecular function","AKR1C2","ENSG00000151632","Ferroptosis; Alternative pathway of fetal androgen synthesis; Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II; Prostaglandin synthesis and regulation","Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol; Synthesis of bile acids and bile salts via 27-hydroxycholesterol","Steroid hormone biosynthesis; Chemical carcinogenesis; Chemical carcinogenesis",2.807,0.899,0.896,0.973,1.085,0.000206575869914355,1,1,1,1,219.9,70.5,70.2,78.3,76.2,85,261.2,221.2,191.9,73.6,70.9,67.3,70.6,71.3,68.3,78.8,73.7,78.8,67.2,95.6,76.6,85.8,61.6,85.5,601.5,509.2,441.9,169.5,163.2,154.9,162.5,164.2,157.2,181.5,169.7,181.4,154.8,220.1,176.5,197.6,141.9,196.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P35443","Thrombospondin-4 [OS=Homo sapiens]",2,1,1,1,961,105.8,4.68,3.35,"cell adhesion;stress response;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;cytosol;ER/Golgi","signal transduction activity or receptor binding;other molecular function","THBS4","ENSG00000113296","Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway","Signaling by PDGF","Phagosome; PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Malaria; Human papillomavirus infection",2.823,0.933,0.932,1.043,1.277,0.00403354690907118,1,1,1,0.636094842570645,211.5,69.9,69.8,74.9,78.2,95.7,326.9,200.6,184,62.8,87.1,66.3,70.4,49.4,66.2,71.1,36.5,74.1,78,74.1,66,110.6,85.2,90.7,62.3,38.2,35.1,12,16.6,12.6,13.4,9.4,12.6,13.5,6.9,14.1,14.9,14.1,12.6,21.1,16.2,17.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P23142","Fibulin-1 [OS=Homo sapiens]",15,8,12,8,703,77.2,5.22,29.01,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;extracellular matrix","signal transduction activity or receptor binding;enzyme regulator activity;extracellular structural activity;other molecular function","FBLN1","ENSG00000077942","","Molecules associated with elastic fibres","",2.958,0.954,0.944,1.018,1.043,2.12542897540883E-5,1,1,1,1,224.2,72.3,71.5,75.8,77.1,79.1,277.1,219.2,204,80.2,68.7,70.7,66.6,70,73.2,70.4,74.1,76.7,60.2,79.8,75.4,81.5,77.3,74.8,935.1,739.8,688.5,270.8,231.7,238.5,224.7,236.1,247,237.6,250.1,258.9,203.2,269.3,254.5,275,260.9,252.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q6UXK2","Immunoglobulin superfamily containing leucine-rich repeat protein 2 [OS=Homo sapiens]",2,1,3,1,745,78.9,5.29,0,"cell organization and biogenesis;developmental processes","plasma membrane;other membranes;other cell component","","ISLR2","ENSG00000167178","","","",3.027,1.137,0.974,1.068,1.151,3.15826257986852e-05,1,1,1,1,217.3,81.6,70,71.8,76.7,82.6,252.6,214.5,180.2,80.6,88.9,73,64.9,69.1,75.1,70.9,65.9,77.2,75.7,74.1,89.8,81.6,80.4,85.5,218.2,185.3,155.6,69.6,76.8,63.1,56,59.7,64.9,61.2,56.9,66.7,65.4,64,77.6,70.5,69.5,73.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O95789","Zinc finger MYM-type protein 6 [OS=Homo sapiens]",3,3,4,3,1325,148,8.22,0,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZMYM6","ENSG00000163867","","","",3.298,1.189,0.973,0.957,1.02,0.0015762791162561,1,1,1,1,234.5,84.6,69.2,71.1,68,72.5,383,212.2,218.3,78.7,51.6,85.7,68.1,64.4,45.8,56.2,66.2,69.2,58.9,78.4,63.3,75,57.3,67.5,160.2,88.8,91.3,32.9,21.6,35.9,28.5,26.9,19.2,23.5,27.7,28.9,24.6,32.8,26.5,31.4,24,28.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P00488","Coagulation factor XIII A chain [OS=Homo sapiens]",7,4,7,4,732,83.2,6.09,10.39,"protein metabolism;other metabolic processes;stress response","non-structural extracellular;other cell component","other molecular function","F13A1","ENSG00000124491","Complement system","Platelet degranulation ; Interleukin-4 and Interleukin-13 signaling; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades; Coronavirus disease",3.4,1.072,0.962,1.075,1.003,1.47889314590075e-05,1,1,1,1,239.7,75.6,67.8,70.5,75.8,70.7,305.1,229.3,208.1,82.7,72.3,72,68.4,61.1,64.8,66.7,67.4,72.3,72.5,81.9,65.6,75.9,67.7,66.2,1067.8,802.4,728.3,289.5,253,252.1,239.5,213.8,227,233.4,236,253.1,253.8,286.5,229.5,265.8,236.8,231.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q00G26","Perilipin-5 [OS=Homo sapiens]",5,2,2,2,463,50.8,5.2,0,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","PLIN5","ENSG00000214456","","","PPAR signaling pathway",3.453,2.919,3.511,4.328,4.799,1.17302957221512E-3,0.00875727218960885,0.00126171997878437,0.000339277705774406,0.000118174227718007,103.6,87.5,105.3,30,129.8,143.9,108.4,90.9,95.8,76.7,86.8,81,86.8,139.2,97.4,22.8,27.7,31.8,120.1,103.3,169.6,132.1,196.5,133.1,35.6,29.8,31.4,25.2,28.5,26.6,28.5,45.7,32,7.5,9.1,10.4,39.4,33.9,55.7,43.3,64.5,43.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q99574","Neuroserpin [OS=Homo sapiens]",3,1,1,1,410,46.4,4.91,2.77,"developmental processes;other biological processes","non-structural extracellular;other cell component","enzyme regulator activity","SERPINI1","ENSG00000163536","","","",3.505,2.908,3.764,3.27,2.83,1.31179483596983E-4,1.49809557982753E-3,1.76775270254899E-4,0.000189368711234734,0.000332275582390043,121.7,101,130.7,34.7,113.6,98.3,104.5,119.2,138.9,98.9,84.7,106.3,109.6,131.5,128.1,39.7,34,33.2,111.2,141.5,101.5,126.8,96.3,94.1,24,27.4,31.9,22.7,19.4,24.4,25.2,30.2,29.4,9.1,7.8,7.6,25.5,32.5,23.3,29.1,22.1,21.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P17029","Zinc finger protein with KRAB and SCAN domains 1 [OS=Homo sapiens]",3,2,2,1,563,63.6,7.05,1.96,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZKSCAN1","ENSG00000106261","","Generic Transcription Pathway","",3.551,2.127,2.913,3.461,4.167,0.000163005840695407,0.0268941638367262,0.00142446482230374,0.000120380544359914,3.39408280367633e-05,123.7,74.1,101.5,34.8,120.6,145.2,122.3,104.6,128.4,76.1,73.2,63.6,82,102.5,100.3,31.3,34.4,47.4,145.1,119.2,119.1,168.1,138.6,143.5,42.3,36.2,44.4,26.3,25.3,22,28.4,35.5,34.7,10.8,11.9,16.4,50.2,41.2,41.2,58.2,47.9,49.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P02748","complement component C9 [OS=Homo sapiens]",4,2,4,2,559,63.1,5.59,2.69,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes","","C9","ENSG00000113600","Allograft rejection; Complement system; Complement system in neuronal development and plasticity; Complement activation; Complement and coagulation cascades","Regulation of Complement cascade; Terminal pathway of complement","Complement and coagulation cascades; Prion disease; Amoebiasis; Coronavirus disease; Systemic lupus erythematosus",3.57,1.16,1.179,1.18,1.288,0.000330529575468151,1,1,1,1,228.4,74.2,75.5,64,75.5,82.4,322.1,218.1,180.3,70.9,69.4,81.6,72.3,63.2,72,59.1,66.9,61.1,72.1,83.5,69.4,97.4,61.9,78.7,493.1,333.8,276,108.5,106.3,124.9,110.8,96.8,110.3,90.6,102.4,93.5,110.4,127.8,106.3,149.2,94.7,120.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P62633-4","Isoform 4 of Cellular nucleic acid-binding protein [OS=Homo sapiens]",55,9,58,1,178,19.6,7.58,106.78,"","","","CNBP","","","","",3.696,0.922,0.873,0.837,0.839,0.00018051861627197,1,1,1,1,271.5,67.7,64.1,73.5,61.5,61.6,352.4,267,219.2,57.2,67.6,66.6,63,50.4,66.8,69.1,72.2,81.8,49.3,74.8,60.5,62.1,60.6,59.5,124,94,77.1,20.1,23.8,23.4,22.2,17.8,23.5,24.3,25.4,28.8,17.4,26.3,21.3,21.9,21.3,20.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P00734","Prothrombin [OS=Homo sapiens]",5,2,5,2,622,70,5.9,5.85,"protein metabolism;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","F2","ENSG00000180210","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; IL1 and megakaryocytes in obesity; Regulation of actin cytoskeleton; Complement and coagulation cascades","Cell surface interactions at the vascular wall; Regulation of Complement cascade; G alpha (q) signalling events; Peptide ligand-binding receptors; Thrombin signalling through proteinase activated receptors (PARs); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Defective F8 cleavage by thrombin; Gamma-carboxylation of protein precursors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Platelet Aggregation (Plug Formation); Defective factor XII causes hereditary angioedema","Phospholipase D signaling pathway; Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Platelet activation; Regulation of actin cytoskeleton; Pathogenic Escherichia coli infection; Coronavirus disease; Pathways in cancer",3.773,1.014,1.038,1.36,1.374,0.000152003169578904,1,1,1,0.957734512582963,236.8,63.6,65.1,62.8,85.4,86.2,300.9,230.7,223.9,80.7,57.5,62,63.5,63.1,65.6,63.4,61.1,60.9,52.4,88.8,83.2,84,71.8,86.5,307.2,235.5,228.5,82.4,58.7,63.3,64.8,64.4,67,64.7,62.4,62.2,53.5,90.7,84.9,85.7,73.3,88.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q8TDP1","Ribonuclease H2 subunit C [OS=Homo sapiens]",48,4,8,4,164,17.8,5.03,13.47,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","RNASEH2C","ENSG00000172922","","","DNA replication",3.885,1.032,1.021,1.075,1.042,0.000108518211602535,1,1,1,1,257.4,68.4,67.6,66.3,71.2,69,353.4,245.3,208.3,80.4,62,65.2,64.5,70,60.1,63.1,62.6,67,55,76.1,67.9,74.2,59,65.8,981.4,681.3,578.5,223.3,172.2,181,179,194.5,167,175.4,173.8,186.2,152.9,211.5,188.5,206,163.9,182.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P08603-1","complement factor H [OS=Homo sapiens]",1,1,2,1,1231,139,6.61,4.82,"stress response;other biological processes","non-structural extracellular","other molecular function","CFH","ENSG00000000971","Complement system; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Complement and coagulation cascades","Regulation of Complement cascade","Complement and coagulation cascades; Staphylococcus aureus infection",4.368,0.942,0.973,1.025,1.236,0.000152003169578904,1,1,1,1,274.6,59.2,61.2,62.9,64.4,77.7,380.4,257.5,256.5,64.6,49,55.5,61.5,54.4,57.4,63.2,46.3,58.9,46.1,84.2,60.4,72.9,56.8,74.4,231.3,156.6,156,39.3,29.8,33.8,37.4,33.1,34.9,38.5,28.2,35.8,28,51.2,36.7,44.3,34.5,45.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P03971","Muellerian-inhibiting factor [OS=Homo sapiens]",2,1,1,1,560,59.2,7.33,3.19,"cell-cell signaling;developmental processes;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","AMH","ENSG00000104899","Mesodermal commitment pathway; Mesodermal commitment pathway; Somatic sex determination; Mammalian disorder of sexual development; Kisspeptin/kisspeptin receptor system in the ovary","Signaling by BMP; Transcriptional regulation of testis differentiation","cAMP signaling pathway; Cytokine-cytokine receptor interaction; TGF-beta signaling pathway; Hippo signaling pathway",4.454,2.9,4.777,6.734,5.841,0.107225312042836,0.717102764896174,0.165977601382268,0.0199486296445685,0.0536298664525204,104,67.7,111.5,23.3,157.2,136.3,125.4,100.3,86,65.3,89.6,59.2,107.6,81,111.5,22.5,67.3,14.8,151.7,201.8,133.5,161,89.8,131.6,18,14.4,12.3,9.4,12.8,8.5,15.4,11.6,16,3.2,9.6,2.1,21.7,28.9,19.1,23.1,12.9,18.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P02647","Apolipoprotein A-I [OS=Homo sapiens]",8,2,10,1,267,30.8,5.76,21.78,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","APOA1","ENSG00000118137","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5","PPARA activates gene expression; Platelet degranulation ; Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging of heme from plasma; Scavenging by Class B Receptors; Heme signaling; Retinoid metabolism and transport; HDL clearance; Defective ABCA1 causes TGD; HDL assembly; Scavenging by Class A Receptors; ABC transporters in lipid homeostasis; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","PPAR signaling pathway; Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; African trypanosomiasis; Lipid and atherosclerosis",4.55,1.171,1.357,2.352,2.361,0.0431215928613786,1,1,0.529062236260442,1,213.4,54.9,63.6,46.9,110.3,110.7,231.5,225.5,194.7,58,57.8,69.5,67.3,48.2,72.2,46.1,49.6,56,116.6,142.9,96.9,121.4,28.8,117,432.3,421.2,363.5,108.4,108,129.8,125.6,89.9,134.9,86.1,92.6,104.5,217.7,266.8,180.9,226.7,53.9,218.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q92817","Envoplakin [OS=Homo sapiens]",0,1,2,1,2033,231.5,6.96,4.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","EVPL","ENSG00000167880","","Formation of the cornified envelope","",4.786,0.988,1.046,0.889,0.927,1.54435619908365E-4,1,1,1,1,298,61.6,65.1,62.3,55.3,57.7,422.3,271.8,258.5,63.5,56.1,52.3,61.8,48.5,59.4,56.8,52.6,57.8,39.1,72.6,50.5,71.4,52.4,52.6,857.4,551.9,524.9,128.8,114,106.2,125.5,98.5,120.6,115.3,106.7,117.5,79.4,147.3,102.5,145,106.5,106.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q15582","Transforming growth factor-beta-induced protein ig-h3 [OS=Homo sapiens]",6,3,3,3,683,74.6,7.71,9.21,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding;extracellular structural activity;other molecular function","TGFBI","ENSG00000120708","","Amyloid fiber formation","",4.934,1.039,1.032,1.107,1.282,0.000161678656107771,1,1,1,1,284.8,60,59.6,57.7,63.9,74,353.6,261.6,265.9,69.9,50.9,56,51.1,55.6,62.7,53.9,47.9,67,51.7,88.2,59.7,81.5,69.1,53.7,329.5,243.8,247.9,65.2,47.5,52.2,47.6,51.8,58.4,50.2,44.6,62.5,48.2,82.2,55.6,76,64.4,50.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P01024","Complement C3 [OS=Homo sapiens]",1,2,4,2,1663,187,6.4,5.7,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","C3","ENSG00000125730","Allograft rejection; Complement system; TYROBP causal network in microglia; Cells and molecules involved in local acute inflammatory response ; 16p11.2 distal deletion syndrome; Complement system in neuronal development and plasticity; Acquired partial lipodystrophy / Barraquer-Simons syndrome; Complement activation; Complement and coagulation cascades","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; G alpha (i) signalling events; Neutrophil degranulation; Peptide ligand-binding receptors; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Purinergic signaling in leishmaniasis infection; Alternative complement activation; Activation of C3 and C5","Neuroactive ligand-receptor interaction; Phagosome; Complement and coagulation cascades; Neutrophil extracellular trap formation; Alcoholic liver disease; Shigellosis; Pertussis; Legionellosis; Leishmaniasis; Chagas disease; Staphylococcus aureus infection; Tuberculosis; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Coronavirus disease; Viral carcinogenesis; Systemic lupus erythematosus",5.199,1.017,0.911,1.113,1.427,0.00060183699336992,1,1,1,1,292.5,57.2,51.2,56.2,62.6,80.3,392.6,288,239,63.4,48.6,56.4,50.4,51.1,45.4,42,55.4,64.7,50.6,81,61.6,87.3,43.6,79,340.3,249.6,207.1,55,42.1,48.8,43.7,44.3,39.3,36.4,48,56.1,43.8,70.2,53.4,75.7,37.8,68.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q9UGM3-1","deleted in malignant brain tumors 1 protein [OS=Homo sapiens]",5,1,2,1,2413,260.6,5.44,4.53,"stress response;transport;other biological processes","non-structural extracellular;extracellular matrix;other membranes;other cell component","nucleic acid binding activity;other molecular function","DMBT1","ENSG00000187908","","Surfactant metabolism","Salivary secretion",5.474,1.288,1.246,1.378,1.405,5.65827102416386E-4,1,1,1,1,278.6,65.5,63.4,50.9,70.1,71.5,382,243.8,267.4,79.1,62.9,43.3,60.9,60.4,60.9,58.1,32.1,48.8,67.3,75.1,56.5,88,44.6,68.6,94.9,60.6,66.4,19.6,15.6,10.8,15.1,15,15.1,14.4,8,12.1,16.7,18.7,14,21.9,11.1,17.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P08697-1","Alpha-2-antiplasmin [OS=Homo sapiens]",2,1,4,1,491,54.5,6.29,6.35,"cell organization and biogenesis;stress response;developmental processes;other biological processes","non-structural extracellular;other cell component","enzyme regulator activity;other molecular function","SERPINF2","ENSG00000167711; ENSG00000276838","Blood clotting cascade; Complement and coagulation cascades","Platelet degranulation ; Dissolution of Fibrin Clot","Complement and coagulation cascades",6.052,1.234,0.996,1.158,1.354,2.04419942829002E-4,1,1,1,1,307.9,62.8,50.7,50.9,58.9,68.9,445.3,276.9,265.3,64.3,42.2,56.5,45.6,36.4,50.1,45.8,42.6,64.7,41.9,66,53,81.8,59.6,61.9,571.1,355.1,340.3,82.5,54.2,72.4,58.4,46.7,64.2,58.7,54.6,83,53.7,84.6,67.9,104.9,76.5,79.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q14764","major vault protein [OS=Homo sapiens]",1,1,1,1,893,99.3,5.48,2.41,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MVP","ENSG00000013364","16p11.2 proximal deletion syndrome","Neutrophil degranulation","",6.133,1.152,0.824,1.369,1.124,0.0142313203615871,1,1,1,1,317.2,59.6,42.6,51.7,70.8,58.1,399,292.4,271,80.8,54.9,47.5,17.1,39.3,104.9,39.3,51.3,47.7,65.3,60.4,71.3,53.6,48.9,55.5,60.6,44.4,41.2,12.3,8.3,7.2,2.6,6,15.9,6,7.8,7.2,9.9,9.2,10.8,8.1,7.4,8.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P01023","alpha-2-macroglobulin [OS=Homo sapiens]",5,8,58,8,1474,163.2,6.46,101.45,"other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","A2M","ENSG00000175899","Complement system; Complement and coagulation cascades","Degradation of the extracellular matrix; Platelet degranulation ; HDL assembly; Intrinsic Pathway of Fibrin Clot Formation","Complement and coagulation cascades",6.423,1.194,1.089,1.139,1.212,2.6749709228298e-05,1,1,1,1,319.6,59.4,54.2,49.8,56.7,60.3,412.7,302,248.4,64.6,51.7,56.1,50.8,51.2,57.4,45.9,47,58.3,47.7,69.7,53.6,73.3,52.8,57,14548.2,10645.8,8758.7,2276.6,1821.3,1978.6,1791.6,1804.2,2025,1617.2,1657.5,2054,1683,2457.5,1888.5,2583.2,1860,2008.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","P98164","Low-density lipoprotein receptor-related protein 2 [OS=Homo sapiens]",0,1,1,1,4655,521.6,5.08,1.62,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","LRP2","ENSG00000081479","Vitamin B12 metabolism; Complement system; Hedgehog signaling pathway","Cargo recognition for clathrin-mediated endocytosis; Retinoid metabolism and transport; Vitamin D (calciferol) metabolism","Hedgehog signaling pathway; Thyroid hormone synthesis; Cholesterol metabolism",6.807,1.235,1.356,1.367,1.805,4.94685578904819E-5,1,1,1,0.352645940886638,301,54.6,60,44.2,60.4,79.8,378.9,284,260.3,68.3,44.3,51.5,56.6,49.1,56.6,41.5,41.7,55.2,50.1,82.5,57,83.6,63.5,75.3,592.5,444.1,407,106.9,69.2,80.6,88.5,76.8,88.5,64.8,65.2,86.3,78.4,129,89.2,130.7,99.4,117.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q96S21","Ras-related protein Rab-40C [OS=Homo sapiens]",3,1,5,1,281,31.3,9.19,0,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB40C","ENSG00000197562","","RAB geranylgeranylation","",7.001,0.969,0.954,0.919,0.949,2.04419942829002E-4,1,1,1,1,356.2,49.3,48.6,50.9,46.8,48.3,474.3,331,271.1,60.7,45,45.8,34.9,45.1,52.7,46.4,47.3,49.6,31.7,60.9,43.4,71,44.2,44.9,1368.2,954.8,782,175,129.7,132.1,100.7,130.1,152,133.8,136.4,143,91.5,175.7,125.3,204.7,127.4,129.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P02679","Fibrinogen gamma chain [OS=Homo sapiens]",7,3,26,3,453,51.5,5.62,46.62,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGG","ENSG00000171557","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway","ER-Phagosome pathway; Platelet degranulation ; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Staphylococcus aureus infection; Coronavirus disease",7.086,1.062,1.007,1.018,1.028,9.16859284869292e-05,1,1,1,1,348.5,52.2,49.5,49.2,50.1,50.5,489.5,303.7,293.1,59.1,45.5,44.1,43.1,39.2,49.8,40.4,42.9,53.2,35.5,60.4,43.6,69.3,44,43.6,4212.8,2613.9,2522.4,508.4,391.8,379.7,371.3,337.3,428.3,347.7,368.9,457.6,306,520.2,375.5,596.2,379,374.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P08123","Collagen alpha-2(I) chain [OS=Homo sapiens]",3,4,6,4,1366,129.2,8.95,11.3,"cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi","extracellular structural activity;other molecular function","COL1A2","ENSG00000164692","miRNA targets in ECM and membrane receptors; Focal adhesion; TGF-beta signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Angiotensin II receptor type 1 pathway; CCL18 signaling pathway; NRP1-triggered signaling pathways in pancreatic cancer","Integrin cell surface interactions; Cell surface interactions at the vascular wall; ECM proteoglycans; Interleukin-4 and Interleukin-13 signaling; Syndecan interactions; MET activates PTK2 signaling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); GP1b-IX-V activation signalling; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Collagen degradation; Collagen chain trimerization; GPVI-mediated activation cascade; Anchoring fibril formation; Crosslinking of collagen fibrils; Scavenging by Class A Receptors","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Platelet activation; Relaxin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Protein digestion and absorption; Amoebiasis; Human papillomavirus infection; Proteoglycans in cancer; Diabetic cardiomyopathy",7.736,1.37,1.06,1.262,1.393,0.000780547421087728,1,1,1,1,335.8,59.5,46,43.4,54.8,60.5,440.8,313.7,255.2,61,46.5,55.5,37.8,43,52.9,40.6,40.5,64.8,32.3,73.9,51.2,83.8,56.5,50,1409.6,1003.3,816.3,195,148.8,177.7,120.7,137.5,169,129.7,129.5,207.4,103.4,236.3,163.7,268.1,180.7,160,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P02458-1","Isoform 1 of Collagen alpha-1(II) chain [OS=Homo sapiens]",3,4,4,4,1418,134.3,8.56,4.78,"","","","COL2A1","","","","",8.291,0.978,0.847,1.119,1.07,0.00160553053125427,1,1,1,1,373.9,44.1,38.2,45.1,50.4,48.2,556,331.1,288.2,39,32.2,51.5,25.7,33.8,39.1,39.9,22.2,45.1,20.9,57,44.7,88.7,42.7,42.2,1380.9,822.3,715.7,96.9,80,127.9,63.8,84,97.1,99.2,55.2,112.1,51.8,141.6,110.9,220.3,106.1,104.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P02751","fibronectin [OS=Homo sapiens]",30,55,452,55,2386,262.5,5.71,976.91,"","","","","","","","",8.659,1.228,1.112,1.186,1.26,1.34860439171014E-4,1,1,1,1,359.7,51,46.2,41.5,49.3,52.3,471.5,327.1,302.7,60.3,41.6,46.4,38,42,47.2,37.8,35.9,53.4,29.6,64.4,44.8,66.2,47.6,43.6,80901.1,56124.8,51934.1,10355.4,7145.4,7960,6513.4,7207.5,8100.9,6481.7,6159.6,9166.5,5080,11050.6,7686.7,11357.9,8164.8,7477.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Medium","Q9C000","NACHT, LRR and PYD domains-containing protein 1 [OS=Homo sapiens]",1,1,6,1,1473,165.8,6.84,0,"cell organization and biogenesis;protein metabolism;stress response;other biological processes","cytosol;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","NLRP1","ENSG00000091592","Nucleotide-binding oligomerization domain (NOD) pathway; Network map of SARS-CoV-2 signaling pathway","The NLRP1 inflammasome","NOD-like receptor signaling pathway",9.263,1.041,0.905,1.03,1.273,0.00021723906346917,1,1,1,1,383,43,37.4,41.3,42.6,52.6,554.9,347.4,320.2,49.8,32.7,39.1,29.1,34,36,37.5,35,39.3,20.9,54.1,38.6,54,47.7,29.7,1313.7,822.5,758,117.8,77.3,92.5,68.9,80.4,85.3,88.8,82.9,92.9,49.5,128,91.4,127.9,113,70.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P02452","Collagen alpha-1(I) chain [OS=Homo sapiens]",9,11,16,11,1464,138.9,5.8,18.87,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi;other cell component","extracellular structural activity;other molecular function","COL1A1","ENSG00000108821","Focal adhesion; Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miR-509-3p alteration of YAP1/ECM axis; PI3K-Akt signaling pathway; Inflammatory response pathway; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Angiotensin II receptor type 1 pathway; Burn wound healing; CCL18 signaling pathway; NRP1-triggered signaling pathways in pancreatic cancer","GPVI-mediated activation cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Collagen degradation; Integrin cell surface interactions; ECM proteoglycans; Collagen chain trimerization; Syndecan interactions; MET activates PTK2 signaling; RUNX2 regulates osteoblast differentiation; Anchoring fibril formation; Crosslinking of collagen fibrils; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); Scavenging by Class A Receptors; GP1b-IX-V activation signalling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Platelet activation; Relaxin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Protein digestion and absorption; Amoebiasis; Human papillomavirus infection; Proteoglycans in cancer; Diabetic cardiomyopathy",9.894,1.313,1.075,1.245,1.305,0.000434882641970189,1,1,1,1,375,49.7,40.7,37.9,47.2,49.4,507.7,344.1,288.8,51.5,37.4,45.7,25.8,37.4,41.7,34.8,31.8,54.1,28,62.3,43.3,76.8,45.4,43.6,4120.4,2792.6,2343.7,418.1,303.2,370.5,209.7,303.4,338.1,282.2,258.2,439,227.1,505.3,351.4,622.9,368.2,353.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q15063-1","Periostin [OS=Homo sapiens]",5,3,4,3,836,93.3,7.53,13.01,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi;other cell component","other molecular function","POSTN","ENSG00000133110","Hypothesized pathways in pathogenesis of cardiovascular disease; Amplification and expansion of oncogenic pathways as metastatic traits","","",10.076,1.53,1.151,1.348,1.471,0.000204763368119271,1,1,1,1,364.7,55.4,41.7,36.2,48.8,53.2,460.2,325.6,331.1,58,34.8,50.3,36.7,43.6,37.8,32.9,32.1,54.9,28.9,63.6,44.3,71.9,48.3,45,693.6,490.8,499.1,87.4,52.4,75.8,55.4,65.8,57,49.5,48.4,82.7,43.6,95.8,66.8,108.3,72.8,67.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","O15083","ERC protein 2 [OS=Homo sapiens]",6,7,14,1,957,110.5,6.99,27.61,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","ERC2","ENSG00000187672","Exercise-induced circadian regulation","","",10.773,1.137,0.957,1,0.998,0.000524389457974471,1,1,1,1,407.4,43,36.2,37.8,37.8,37.7,550.8,371.5,311.2,50.4,33.4,39.2,32.1,33,44.9,34.5,25.2,41.1,18.8,60.2,34.5,54.8,29.9,34.4,1063.6,717.4,601,97.3,64.6,75.8,61.9,63.8,86.7,66.6,48.7,79.4,36.4,116.2,66.6,105.8,57.8,66.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","P02675","Fibrinogen beta chain [OS=Homo sapiens]",11,7,61,7,491,55.9,8.27,96.62,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGB","ENSG00000171564","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway; Complement and coagulation cascades","Platelet degranulation ; Common Pathway of Fibrin Clot Formation; ER-Phagosome pathway; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease",11.372,1.093,0.965,1.151,1.103,0.000550829274083804,1,1,1,1,409,39.3,34.7,36,41.4,39.7,575.3,344.1,334.8,56.4,31.5,33.1,29.2,27.6,38.5,30.3,26.4,43.4,18.1,48.2,34.8,62.5,33.4,32.5,14353.1,8584.5,8352.9,1407.2,785,825,728.4,689.6,959.8,754.9,658,1084,452.2,1203.8,868.8,1559.3,832.5,810.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["High","Q16610","Extracellular matrix protein 1 [OS=Homo sapiens]",5,2,11,2,540,60.6,6.71,22.43,"stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;other molecular function","ECM1","ENSG00000143369","","Platelet degranulation","",12.453,1.18,1.125,1.153,1.191,0.000337067303380564,1,1,1,1,412.8,39.1,37.3,33.1,38.2,39.5,576.9,350.9,345.3,52.4,29,33.3,26.4,31.7,36.6,28.2,20.1,46.9,19.8,45.8,32.5,57.2,33.6,33.4,3452.8,2100.3,2066.6,313.7,173.4,199,158.3,189.8,218.9,168.7,120.5,280.8,118.7,274.3,194.4,342.1,200.9,199.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]
["Low","Q5T0L3","Spermatogenesis-associated protein 46 [OS=Homo sapiens]",8,1,1,1,261,29.1,7.52,0,"cell organization and biogenesis;other biological processes","other membranes;nucleus","","SPATA46","ENSG00000171722","","","",19.259,0.351,0.384,1.488,1.07,0.00544433515118988,1,1,1,1,490.6,9,9.8,25.5,37.9,27.3,589.9,479.6,392.5,27.7,8.8,8.4,5.9,9.6,11,6,47.5,24.9,26.9,37.1,39.1,43.8,26.7,14.8,142,115.4,94.5,6.7,2.1,2,1.4,2.3,2.6,1.5,11.4,6,6.5,8.9,9.4,10.5,6.4,3.6,"High","High","High","High","High","High","High","High","High","High","Not Found","High","Not Found","High","Not Found","High","Not Found","High",1]
["High","P02671-1","Fibrinogen alpha chain [OS=Homo sapiens]",2,3,10,3,866,94.9,6.01,16.25,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGA","ENSG00000171560","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway","Regulation of TLR by endogenous ligand; Platelet degranulation ; Integrin cell surface interactions; Amyloid fiber formation; ER-Phagosome pathway; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease",20.726,1.263,0.962,1.121,1.158,0.000492897804212252,1,1,1,1,474.1,28.9,22,22.9,25.6,26.5,629,428.5,345.3,42.3,22.6,26.1,19.9,19.5,27.2,20.7,16.7,33.6,12,42.2,23.2,46.3,21,23.9,4699.6,3201.7,2580,316.2,168.8,195.1,148.6,146,203.2,154.5,125.1,251,89.4,315,173.1,346,157,178.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High",1]

{"sheet":"ARV-825","index":1,"n_rows":7809,"n_cols":32,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["Protein FDR Confidence: Combined","Accession","Description","Coverage [%]","# Peptides","# PSMs","# Unique Peptides","# AAs","MW [kDa]","calc. pI","Score Sequest HT: Sequest HT","Biological Process","Cellular Component","Molecular Function","Gene Symbol","Ensembl Gene ID","WikiPathways","Reactome Pathways","KEGG Pathways","Abundances (Normalized): F19: 127N, Sample, ARV","Abundances (Normalized): F19: 128N, Sample, ARV","Abundances (Normalized): F19: 129N, Sample, ARV","Abundances (Normalized): F19: 126, Sample, DMSO","Abundances (Normalized): F19: 127C, Sample, DMSO","Abundances (Normalized): F19: 128C, Sample, DMSO","Ratio","log2(Ratio)","P-Value","− log10(P-Value)","q-Value","− log10(q-Value)","Rank (P-Value)"]
["Medium","A0A0B4J2F0","Protein PIGBOS1 [OS=Homo sapiens]",19,1,1,1,54,6.3,8.5,0,"stress response;other biological processes","other membranes;mitochondrion","","PIGBOS1","ENSG00000225973","","","",46.6,54.7,56.4,51.5,54.7,56.6,{"$f":"AVERAGE(T2:V2)/AVERAGE(W2:Y2)","v":0.9686732186732187},{"$f":"LOG(Z2,2)","v":-0.04591803947573682},{"$f":"TTEST(T2:V2,W2:Y2,2,2)","v":0.6404457296153349},{"$f":"-LOG10(AB2)","v":0.19351766580559768},{"$f":"AB2*7808/AF2","v":0.7752868615250441},{"$f":"-LOG10(AD2)","v":0.11053757578223004},6450]
["High","A0AV96","RNA-binding protein 47 [OS=Homo sapiens]",13,6,11,6,593,64.1,7.68,29.14,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","RBM47","ENSG00000163694","TYROBP causal network in microglia","","",277.3,272.7,269.6,338,389.1,365.5,0.7501372872048325,-0.41477343868674776,3.6684670535216597E-3,2.4355153769675617,0.037054839267654745,1.4311550662272512,773]
["High","A0AVF1","intraflagellar transport protein 56 [OS=Homo sapiens]",10,4,5,4,554,64.1,6.93,8.28,"cell organization and biogenesis;transport;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","TTC26","ENSG00000105948","Ciliary landscape; Genes related to primary cilium development (based on CRISPR)","Intraflagellar transport","",145.6,188.6,147.2,164.5,182.6,155.9,0.9570576540755468,-0.06332225821839248,0.6783253923788093,0.1685619252855744,0.8017506302896977,0.09596068998233437,6606]
["High","A0AVT1-1","Ubiquitin-like modifier-activating enzyme 6 [OS=Homo sapiens]",33,26,66,26,1052,117.9,6.14,133.34,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBA6; UBE1L2","ENSG00000033178","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",2056.8,2020.5,1983.8,2226.3,2165.4,2198.9,0.9196583012168846,-0.12083016709753708,3.0136891378349183E-3,2.5209015472057303,0.033472097849523534,1.475317067566919,703]
["High","A0FGR8-2","Isoform 2 of Extended synaptotagmin-2 [OS=Homo sapiens]",17,12,21,12,893,98.8,8.68,40.11,"","","","ESYT2","","","","",749.9,724.3,700.1,655.7,659.6,616.4,1.1255888595537606,0.17067995477265577,0.015370170625922998,1.8133213113235782,0.0761486625934053,1.1183377198184794,1576]
["High","A0JLT2","Mediator of RNA polymerase II transcription subunit 19 [OS=Homo sapiens]",11,1,1,1,244,26.3,9.82,3.66,"other biological processes","nucleus","other molecular function","MED19","ENSG00000156603","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",23.4,25.9,24.3,28.4,27.5,26.2,0.8964677222898904,-0.15767645572079195,0.043290516127683774,1.3636072363150762,0.14077982087669924,0.8514595917134681,2401]
["High","A0JNW5-1","UHRF1-binding protein 1-like [OS=Homo sapiens]",16,14,18,14,1464,164.1,6.32,42.2,"","cytosol;other cytoplasmic organelle","other molecular function","UHRF1BP1L","ENSG00000111647","","RND2 GTPase cycle","",636,619.7,626.2,616.9,586.5,595.9,1.0459067415105874,0.06475421911992106,0.05351609450473053,1.2715155880080464,0.15948613202020456,0.7972770746691565,2620]
["High","A0MZ66","Shootin-1 [OS=Homo sapiens]",29,17,34,17,631,71.6,5.33,61.53,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SHTN1","ENSG00000187164","","Recycling pathway of L1","",1240.1,1169.9,1183.1,1363.7,1291.1,1246.9,0.9209062716251889,-0.1188737663043125,0.06309042274605067,1.2000365625343883,0.17745317752203302,0.7509162196585701,2776]
["Medium","A0PJW6","Transmembrane protein 223 [OS=Homo sapiens]",4,1,1,1,202,22,11.02,0,"developmental processes","other membranes","","TMEM223","ENSG00000168569","","","",58.2,59,62.4,72.8,60.3,73.5,0.8693126815101646,-0.2020529041239125,0.11477628540977888,0.9401478347566882,0.26265335184043187,0.5806170525935381,3412]
["Medium","A0PJZ3","Glucoside xylosyltransferase 2 [OS=Homo sapiens]",2,1,1,1,443,51,9.77,0,"protein metabolism;other metabolic processes","other membranes","other molecular function","GXYLT2","ENSG00000172986","Vitamin D receptor pathway","","Other types of O-glycan biosynthesis",32.4,28.2,28.1,23.5,27.1,26.6,1.148963730569948,0.20033325703298327,0.10156605675208444,0.9932514084720412,0.24259032460087954,0.6151265243937748,3269]
["High","A0PK00","Transmembrane protein 120B [OS=Homo sapiens]",9,2,3,2,339,40.2,8.9,8.9,"cell organization and biogenesis;transport;other biological processes","other membranes;nucleus","","TMEM120B","ENSG00000188735","","","",113.2,138.4,130.8,105,131.5,116.9,1.082059988681381,0.11378048342913197,0.41725910571528685,0.3795941770723155,0.5983395954866776,0.22305225650547392,5445]
["Medium","A1A5C7-1","Solute carrier family 22 member 23 [OS=Homo sapiens]",1,1,1,1,686,73.7,7.74,2.24,"transport","other membranes","transporter activity","SLC22A23","ENSG00000137266","","","",89.1,97.6,100.1,128.9,96.6,105.7,0.8659420289855071,-0.20765764879742077,0.2195094989417088,0.6585466815780882,0.3982179757752932,0.3998791395777856,4304]
["High","A1L020","RNA-binding protein MEX3A [OS=Homo sapiens]",22,8,18,8,520,54.1,7.27,58.94,"","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MEX3A","ENSG00000254726","","","",470.9,524.9,478.7,630.8,595.1,607.7,0.8041557591623036,-0.3144531268078058,0.003797603150012034,2.420490421053685,0.03777284763731715,1.4228202731403021,785]
["High","A1L0T0","Acetolactate synthase-like protein [OS=Homo sapiens]",22,11,18,11,632,67.8,8.15,54.07,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ILVBL","ENSG00000105135","","","",766.2,783.9,759.6,718.7,838.7,802.7,0.9786449726706493,-0.031142512956274414,0.6674354852039764,0.17559070715291655,0.7947744804747061,0.0997560861607965,6557]
["High","A1L170","Uncharacterized protein C1orf226 [OS=Homo sapiens]",8,1,1,1,272,29,5.27,3.81,"","","","C1orf226","ENSG00000239887","","","",35.8,31.4,42.8,37.7,32.4,29.6,1.1033099297893683,0.14183811401382626,0.4475906651741105,0.34911897957364346,0.6272052967838218,0.2025902826669339,5572]
["High","A1X283","SH3 and PX domain-containing protein 2B [OS=Homo sapiens]",22,17,37,17,911,101.5,8.69,68.96,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytoskeleton;other cell component","enzyme regulator activity;other molecular function","SH3PXD2B","ENSG00000174705","","","",1732.6,1713.8,1818,1822.6,1692.6,1699.3,1.0095694697478186,0.013740187749457905,0.769527708410456,0.11377573789473319,0.8655246826950218,0.06272054257149093,6942]
["High","A2AJT9-1","BCLAF1 and THRAP3 family member 3 [OS=Homo sapiens]",9,6,7,6,711,83.8,9.7,7.11,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","BCLAF3","ENSG00000173681","","","",328.9,327.6,330.7,357.1,344.1,359.4,0.9307938902508015,-0.10346635399132789,7.2434588450986164E-3,2.1400540030524073,0.05150904067625683,1.288116538507845,1098]
["High","A2RRP1-1","neuroblastoma-amplified sequence [OS=Homo sapiens]",8,15,28,15,2371,268.4,5.96,49.89,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","NBAS","ENSG00000151779","","COPI-dependent Golgi-to-ER retrograde traffic","",1103.5,1142.5,1142.4,1131.1,1232.1,1154.8,0.9631608868675383,-0.05415128820084923,0.26238331307511353,0.5810637884649752,0.44662936744941933,0.3500527239383223,4587]
["High","A2RTX5","Probable threonine--tRNA ligase 2, cytoplasmic [OS=Homo sapiens]",7,4,5,4,802,92.6,6.05,12.01,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","TARS3","ENSG00000185418","","","Aminoacyl-tRNA biosynthesis",124.3,115.8,109.5,135.7,126.2,131.5,0.8886629384850027,-0.17029177277793164,0.04563011459552391,1.3407484405382928,0.14506512001704017,0.8384369983487874,2456]
["High","A2RU67","Protein FAM234B [OS=Homo sapiens]",2,1,2,1,622,67,5.02,6.52,"","other membranes;cytoskeleton;ER/Golgi","","FAM234B","ENSG00000084444","","","",73,64.4,71.5,84.8,85.6,90.6,0.8003831417624522,-0.3212373143901385,0.005677178861760619,2.2458674229399915,0.04588759063418935,1.3383047446968495,966]
["Medium","A2RUB1","Meiosis-specific coiled-coil domain-containing protein MEIOC [OS=Homo sapiens]",1,1,1,1,952,107.5,7.12,1.86,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","MEIOC","ENSG00000180336","","","",18.4,18.5,20.9,34.2,28.7,27.7,0.6379690949227372,-0.6484415575455564,0.007406380019679831,2.13039400816346,0.052098211886180294,1.283177182291482,1110]
["High","A2RUC4","tRNA wybutosine-synthesizing protein 5 [OS=Homo sapiens]",18,5,6,5,315,36.5,7.55,9.39,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TYW5","ENSG00000162971","","Synthesis of wybutosine at G37 of tRNA(Phe)","",171.2,189.6,183.5,180.7,191.2,169.2,1.0059138791350952,8.506794742642489E-3,0.9044613046045828,0.043610008744672,0.9466533332912309,0.02380903155870542,7460]
["High","A2VDJ0","Transmembrane protein 131-like [OS=Homo sapiens]",1,1,1,1,1609,179.2,6.86,2.49,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","TMEM131L","ENSG00000121210","","","",54.8,64.5,57.8,50.6,64.3,55.7,1.0381008206330595,0.05394656543362369,0.6823887980344774,0.16596811107814152,0.8048476941167975,0.09428629585920606,6620]
["High","A3KMH1","von Willebrand factor A domain-containing protein 8 [OS=Homo sapiens]",12,16,18,16,1905,214.7,7.4,32.67,"","mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","VWA8","ENSG00000102763","","","",521.3,472.7,484.4,498.2,526.8,507.2,0.9648870904581647,-0.051567964492657464,0.3485541349098139,0.4577297608463848,0.5346779342585122,0.2719077385245081,5090]
["High","A3KN83-1","protein strawberry notch homolog 1 [OS=Homo sapiens]",21,17,54,17,1393,154.2,7.88,87.98,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SBNO1","ENSG00000139697","","","",969.3,1069.1,1013.5,951.9,922.4,922.1,1.0913674724645972,0.1261369508267383,0.049273124578165725,1.3073898967462168,0.1519449276091303,0.8183137934328988,2532]
["High","A4D1E9-1","GTP-binding protein 10 [OS=Homo sapiens]",13,5,13,5,387,42.9,9.03,25.82,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","GTPBP10","ENSG00000105793","","","",876.4,891.6,887.8,844.2,903.5,917.3,0.996547842401501,-0.004989027064820742,0.8998662333917686,0.045822044357892916,0.9432347362495542,0.02538021397348426,7449]
["Medium","A4D1F6","Leucine-rich repeat and death domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,860,98,7.46,0,"signal transduction;other biological processes","","","LRRD1","ENSG00000240720","","","",21.1,11.6,12.3,17.4,16.8,18.8,0.8490566037735848,-0.23606735823352462,0.44001965928956965,0.35652791958143554,0.6203816359214446,0.2073410663323558,5538]
["High","A4D1P6-1","WD repeat-containing protein 91 [OS=Homo sapiens]",3,1,1,1,747,83.3,6.58,4.28,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle","enzyme regulator activity","WDR91","ENSG00000105875","","CDC42 GTPase cycle","",34.6,21.9,29,29,30.9,35.5,0.8962264150943396,-0.1580648462322513,0.47107630452519633,0.3269087405352043,0.6466532675338841,0.18932852359827881,5688]
["High","A4D1S0-1","killer cell lectin-like receptor subfamily G member 2 [OS=Homo sapiens]",21,8,17,8,409,42.8,5.87,31.59,"","other membranes","other molecular function","KLRG2","ENSG00000188883","","","",643.3,629.4,635.3,739.8,625.8,634.6,0.9539046095390461,-0.06808309094767005,0.4510972894298111,0.3457297824993026,0.6294080836075706,0.2010676836604572,5596]
["High","A5A3E0","POTE ankyrin domain family member F [OS=Homo sapiens]",11,10,366,1,1075,121.4,6.2,713.12,"","other cell component","","POTEF","ENSG00000196604","","","",30.2,36.1,41.2,28.7,33.4,31.7,1.1460554371002134,0.1966768319614463,0.2576431002716036,0.5889814835312295,0.4410605847227978,0.3555017511135324,4561]
["High","A5LHX3","proteasome subunit beta type-11 [OS=Homo sapiens]",5,1,1,1,300,32.5,6.46,2.96,"protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","other molecular function","PSMB11","ENSG00000222028","","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling","Proteasome",29.6,34.9,32.2,37,30,28.3,1.0146904512067156,0.021039675566899296,0.886562764093791,0.052290513154202106,0.9340550616710727,0.029627521762333308,7411]
["High","A5PLN9-1","Trafficking protein particle complex subunit 13 [OS=Homo sapiens]",16,4,6,4,417,46.5,5.6,10.22,"","cytosol;ER/Golgi","","C5orf44; TRAPPC13","ENSG00000113597","","RAB GEFs exchange GTP for GDP on RABs","",128.6,149.3,133.1,145.9,151.6,136.6,0.9467864547339322,-0.07888902868383567,0.37146140731792204,0.4300863002331557,0.5554137626078773,0.25538336306144593,5222]
["High","A5YKK6","CCR4-NOT transcription complex subunit 1 [OS=Homo sapiens]",22,46,128,46,2376,266.8,7.11,215.71,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","CNOT1","ENSG00000125107","Ciliary landscape","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",4331.9,4408,4181.2,4511.5,4713.7,4706.3,0.9274737106557083,-0.10862170592390792,0.023054694843039267,1.6372406218228535,0.09590360007163058,1.0181650897855643,1877]
["High","A6H8Y1","Transcription factor TFIIIB component B'' homolog [OS=Homo sapiens]",1,3,4,3,2624,293.7,5.11,5.2,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","BDP1","ENSG00000145734; ENSG00000273873","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter","",378.4,451.7,346.8,330,343.8,316.3,1.1886678113321887,0.2493455915315528,0.12412931718014636,0.9061256336030288,0.2766776216222046,0.5580259662620858,3503]
["Medium","A6NCS6","Uncharacterized protein C2orf72 [OS=Homo sapiens]",5,2,2,2,295,30.5,8.34,2.29,"","","","C2orf72","ENSG00000204128","","","",135.4,133.7,130.5,133.6,127.6,129.3,1.0233034571062742,0.03323403476307699,0.2561809604513803,0.5914531504623953,0.4393281219425384,0.3572109961119497,4553]
["High","A6ND36-1","Protein FAM83G [OS=Homo sapiens]",4,3,4,3,823,90.8,6.39,4.73,"signal transduction","cytosol;nucleus","other molecular function","FAM83G","ENSG00000188522","","","",123.7,125.2,114.6,124.5,118.9,103.5,1.0478524070337274,0.06743552352057455,0.47921301665143873,0.319471393909404,0.6533429778268611,0.1848587723640978,5727]
["High","A6NDB9","Paralemmin-3 [OS=Homo sapiens]",9,6,8,6,673,71.7,4.53,23.73,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PALM3","ENSG00000187867; ENSG00000288318","","","",281.6,284.1,292.1,368.5,301.4,306.7,0.878353471226705,-0.1871264620019071,0.14303057362737634,0.8445711196087888,0.3013445005079748,0.5209367299330321,3706]
["High","A6NDG6","glycerol-3-phosphate phosphatase [OS=Homo sapiens]",46,10,23,10,321,34,6.14,47.54,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","PGP","ENSG00000184207","","Glycolysis","Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism",963.9,908.1,973.3,1068.3,979.5,1018.4,0.9279564281521102,-0.10787102915159968,0.08800736837417138,1.0554809652330313,0.22152209292892655,0.654582954051982,3102]
["High","A6NDU8","UPF0600 protein C5orf51 [OS=Homo sapiens]",45,9,22,9,294,33.6,5.26,31.35,"","cytosol;nucleus","","C5orf51","ENSG00000205765","","","",642.1,657.8,630.6,624.8,622.6,610.4,1.03913230702982,0.05537935640142248,0.055640820154103585,1.2546064770664695,0.16332463299369954,0.7869483090389011,2660]
["High","A6NED2","RCC1 domain-containing protein 1 [OS=Homo sapiens]",8,2,3,2,376,40.1,5.27,11.52,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;other cell component","","RCCD1","ENSG00000166965","","","",142.2,128.5,158.3,157.9,145.6,173,0.900314795383001,-0.15149856641039644,0.24747021725424037,0.6064770604089291,0.4300573016517046,0.3664736743433191,4493]
["High","A6NFI3","Zinc finger protein 316 [OS=Homo sapiens]",2,2,4,2,1004,108.4,5.31,7.23,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF316","ENSG00000205903","","","Herpes simplex virus 1 infection",262.5,266.3,285.7,385.8,341.7,377.7,0.7369706840390878,-0.44032086339961196,3.2123916432733627E-3,2.493171512539128,0.034788285645878526,1.4585669725999213,721]
["High","A6NGB9","WAS/WASL-interacting protein family member 3 [OS=Homo sapiens]",4,1,1,1,483,49.4,10.15,2.69,"other biological processes","cytosol;cytoskeleton","cytoskeletal activity","WIPF3","ENSG00000122574","","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs","Endocytosis; Pathogenic Escherichia coli infection; Yersinia infection",18.7,19.1,15.3,15.5,22.9,23.3,0.8606158833063209,-0.21655862834526432,0.3650132279913329,0.4376913965310721,0.5492432615448695,0.2602352625673639,5189]
["High","A6NHQ2","rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 [OS=Homo sapiens]",10,4,13,1,334,34.8,10.35,37.65,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","FBLL1","ENSG00000188573","","","",14.3,14.8,18.9,24.6,22.7,26.4,0.6512890094979649,-0.6186302134865509,0.009027834805622132,2.0444163963890403,0.05763641386941751,1.23930304876669,1223]
["High","A6NHR9-1","structural maintenance of chromosomes flexible hinge domain-containing protein 1 [OS=Homo sapiens]",19,31,63,31,2005,226.2,7.3,124.61,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMCHD1","ENSG00000101596","","","",2726,2791.7,2675,2816.1,2908,2852.8,0.9552052606419568,-0.06611731284791501,0.040977457648493684,1.3874549898948314,0.13620774343100836,0.865798202013802,2349]
["Medium","A6NHX0","Cytosolic arginine sensor for mTORC1 subunit 2 [OS=Homo sapiens]",6,1,2,1,329,36,5.16,0,"other biological processes","cytosol","other molecular function","CASTOR2","ENSG00000274070","","Amino acids regulate mTORC1","mTOR signaling pathway",18,19,12.4,15.8,14.1,21,0.9705304518664047,-0.0431546144910176,0.8723475860134658,0.05931043638650554,0.9262020603199811,0.03329425726071375,7354]
["Medium","A6NHY2","ankyrin repeat and death domain-containing protein 1B [OS=Homo sapiens]",1,1,1,1,528,59.1,8.35,2.29,"signal transduction","","","ANKDD1B","ENSG00000189045","","","",209,203.3,179.6,230.6,219.8,166.3,0.9597859575158098,-0.05921538953330317,0.7240741581863174,0.1402169519771791,0.8342291614458855,0.07871463295856912,6777]
["High","A6NI28","Rho GTPase-activating protein 42 [OS=Homo sapiens]",2,2,3,1,874,98.5,7.99,7.83,"signal transduction;other biological processes","","enzyme regulator activity","ARHGAP42","ENSG00000165895","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",56.2,53.3,60.9,68.6,60.9,74.4,0.8357037763609613,-0.25893643979075825,0.06783957767900728,1.1685168643516908,0.18637981087884897,0.7296011332845064,2842]
["High","A6NIH7","Protein unc-119 homolog B [OS=Homo sapiens]",69,10,32,9,251,28.1,5.68,106.26,"cell organization and biogenesis;transport;developmental processes","cytosol;other cell component","other molecular function","UNC119B","ENSG00000175970","","Trafficking of myristoylated proteins to the cilium","",902.9,907.4,913.3,873.3,874.4,864,1.0428456560860744,0.06052565097717808,1.1239298823136705E-3,2.949260781893399,0.02232988427762122,1.6511135276101905,393]
["High","A6NJ78","Probable methyltransferase-like protein 15 [OS=Homo sapiens]",7,2,3,2,407,46.1,8.62,8.59,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","METTL15","ENSG00000169519","","","",34.6,37.2,40.8,41.9,38.9,39.7,0.9344398340248965,-0.09782631903709403,0.2600995544955216,0.5848603916730328,0.4435154665868164,0.35309123054209485,4579]
["High","A6NK58","Putative lipoyltransferase 2, mitochondrial [OS=Homo sapiens]",10,2,2,2,231,25.2,8.27,0,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","LIPT2","ENSG00000175536","","Glyoxylate metabolism and glycine degradation","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors",40.9,31.1,28.1,38.3,35.6,38.1,0.8937499999999999,-0.16205675810897305,0.3733241612539594,0.42791390195767504,0.5573451340479761,0.25387578616631384,5230]
["High","A6NKD9","Coiled-coil domain-containing protein 85C [OS=Homo sapiens]",8,3,3,3,419,45.2,6.96,1.63,"developmental processes","other cell component","","CCDC85C","ENSG00000205476","","","",46,34.8,45.7,36.1,30.1,29.8,1.3177083333333333,0.39803107397315385,0.07349231295117264,1.1337580842828352,0.19671853943186698,0.7061547087459323,2917]
["High","A6NKF1","SAC3 domain-containing protein 1 [OS=Homo sapiens]",7,2,5,2,404,43.5,8.69,17.18,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","","SAC3D1","","","","",162.7,160.6,159.2,162.5,160.7,152.5,1.0142947235652722,0.02047691708035054,0.522880314050159,0.2815977086395072,0.6866211725704072,0.1632828088497908,5946]
["Medium","A6NMB9","Putative fidgetin-like protein 2 [OS=Homo sapiens]",1,1,1,1,653,66.6,6.73,1.79,"cell organization and biogenesis","nucleus","other molecular function","FIGNL2","ENSG00000261308","","","",22.7,25,29.4,34.6,36.3,30.8,0.7581120943952803,-0.3995169139424657,0.0324448810239588,1.4888538140690402,0.11744535513911467,0.9301641545129499,2157]
["High","A6ZKI3","Retrotransposon Gag-like protein 8B [OS=Homo sapiens]",29,3,6,3,113,13.2,5.07,9.43,"","","","RTL8C","ENSG00000134590","","","",77.1,72.8,74.1,66.4,76.8,65.7,1.0722833891814265,0.1006862398778582,0.25678600346509606,0.5904286518786281,0.4399791781995765,0.35656787580244154,4557]
["High","A7E2V4","Zinc finger SWIM domain-containing protein 8 [OS=Homo sapiens]",2,2,2,2,1837,197.2,6.8,3.1,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","ZSWIM8","ENSG00000214655","","Regulation of expression of SLITs and ROBOs","",59,44.9,56.8,55.7,57.9,55.5,0.9503252513305736,-0.07350673073488959,0.5630710677588839,0.2494367874085498,0.7170867553517152,0.14442829887714867,6131]
["High","A8CG34-1","Nuclear envelope pore membrane protein POM 121C [OS=Homo sapiens]",5,6,12,1,1229,125,10.37,18.15,"","","","","","","","",129.6,114.7,113.2,106.6,91.1,101.4,1.195252423938482,0.257315331433762,0.048536160893192334,1.3139345784128258,0.15086399054699273,0.8214144088193488,2512]
["Low","A8K2U0","Alpha-2-macroglobulin-like protein 1 [OS=Homo sapiens]",0,1,1,1,1454,161,5.73,0,"other biological processes","non-structural extracellular","enzyme regulator activity;other molecular function","A2ML1","ENSG00000166535","","","",92.7,71.3,73.7,59.4,81.7,72.8,1.1112669471715755,0.1522054207773904,0.44491712406320655,0.3517208787135417,0.6249168743812766,0.20417774809346628,5559]
["High","A8MQ14","Zinc finger protein 850 [OS=Homo sapiens]",8,4,5,4,1090,125.4,8.7,12.46,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF850","ENSG00000267041","","","Herpes simplex virus 1 infection",377.5,402.4,401.8,385.4,376.8,402.6,1.0145089285714286,0.020781562136503038,0.6405778064024427,0.19342811207232283,0.7753265404418341,0.11051534930773717,6451]
["Medium","A8MW92","PHD finger protein 20-like protein 1 [OS=Homo sapiens]",1,1,1,1,1017,114.9,6.83,2.1,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF20L1","ENSG00000129292","","","",92.8,81.4,92.3,111.4,100,86.7,0.8939953035893994,-0.16166084234463085,0.26074266859970496,0.583787893952074,0.4444179778272203,0.35220838106952224,4581]
["High","A9UHW6","MIF4G domain-containing protein [OS=Homo sapiens]",18,4,5,4,222,25.4,5.33,10.69,"other biological processes","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","MIF4GD","ENSG00000125457","","","",123,115.8,104.9,138.3,125.2,140.4,0.8509532062391683,-0.23284829433078916,0.04736883985308436,1.3245072517840475,0.148955256372486,0.8269441666799765,2483]
["Medium","B0YJ81","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 [OS=Homo sapiens]",4,1,1,1,288,32.4,9.04,2.63,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","HACD1","ENSG00000165996","","Synthesis of very long-chain fatty acyl-CoAs","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism",43.3,37.2,36.5,31,33.8,37.3,1.1459353574926543,0.19652566359296542,0.1536302205954066,0.8135233458483432,0.3151720342640396,0.5014523251407094,3806]
["High","B2RTY4","unconventional myosin-IXa [OS=Homo sapiens]",4,9,9,8,2548,292.5,8.88,12.24,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","MYO9A","ENSG00000066933","","RHOA GTPase cycle; RHOB GTPase cycle; RHOV GTPase cycle","",339.5,313,335.5,299.2,278.4,285.3,1.1449762429018429,0.19531766417088936,0.015336574767910156,1.8142716237962544,0.07612713018934679,1.118460541760906,1573]
["High","L0R6Q1","SLC35A4 upstream open reading frame protein [OS=Homo sapiens]",22,1,1,1,103,11.1,8.1,3.21,"stress response","other membranes","","SLC35A4","ENSG00000176087","","","",12.8,18.2,17.1,16.7,21.4,17.9,0.8589285714285716,-0.21938993317492425,0.2913912050655937,0.535523560490268,0.47807995989749014,0.32049946063039,4759]
["High","O00115","Deoxyribonuclease-2-alpha [OS=Homo sapiens]",4,2,5,2,360,39.6,8.05,8.52,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","other cytoplasmic organelle","nucleic acid binding activity;other molecular function","DNASE2","ENSG00000105612","","Lysosome Vesicle Biogenesis","Lysosome",512.3,454.1,521.9,638,611.3,621.6,0.7954994922229942,-0.33006708522054523,0.004827245486501093,2.316300614849864,0.042112997495643054,1.3755838455071403,895]
["High","O00116","Alkyldihydroxyacetonephosphate synthase, peroxisomal [OS=Homo sapiens]",39,18,47,18,658,72.9,7.34,100.26,"other metabolic processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","AGPS","ENSG00000018510","Triacylglyceride synthesis","Plasmalogen biosynthesis; TYSND1 cleaves peroxisomal proteins","Ether lipid metabolism; Metabolic pathways; Peroxisome",1391.1,1451.5,1399.5,1369.3,1490.7,1442.4,{"$f":"AVERAGE(T66:V66)/AVERAGE(W66:Y66)","v":0.9859845667534402},{"$f":"LOG(Z66,2)","v":-0.020363030071733644},{"$f":"TTEST(T66:V66,W66:Y66,2,2)","v":0.6419284055993841},{"$f":"-LOG10(AB66)","v":0.19251340617875629},{"$f":"AB66*7808/AF66","v":0.7759989148351124},{"$f":"-LOG10(AD66)","v":0.11013888606327053},6459]
["High","O00139-2","Isoform 2 of Kinesin-like protein KIF2A [OS=Homo sapiens]",40,19,66,16,660,75,6.4,111.99,"","","","KIF2A","","","","",1905.5,1873.6,1836.8,1959.8,1793.9,1872.5,0.9981692794426078,-2.6435920475748075E-3,0.9503940766018109,0.022096279125470356,0.9729483348770079,0.01191022085554889,7627]
["High","O00148","ATP-dependent RNA helicase DDX39A [OS=Homo sapiens]",49,19,142,7,427,49.1,5.68,236.83,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","other molecular function","DDX39A","ENSG00000123136","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",1716.7,1802.2,1657.7,1771.5,2006.7,1870.1,0.9164881468760514,-0.12581187266417726,0.12100536920532079,0.9171953589024837,0.2719660111557699,0.5654853683549281,3474]
["High","O00151","PDZ and LIM domain protein 1 [OS=Homo sapiens]",33,10,31,9,329,36,7.02,72.73,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PDLIM1","ENSG00000107438","","","",1430.8,1366.5,1345.2,1644.4,1293.6,1403.2,0.9542292453699438,-0.06759219194009268,0.5686032225428106,0.24519068328681054,0.7207230457166015,0.14223159079260056,6160]
["High","O00154","cytosolic acyl coenzyme A thioester hydrolase [OS=Homo sapiens]",47,16,63,16,380,41.8,8.54,116.69,"other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","ACOT7","ENSG00000097021","","Mitochondrial Fatty Acid Beta-Oxidation","Fatty acid elongation; Biosynthesis of unsaturated fatty acids",2396.1,2329.1,2250.1,2074.2,2321.5,2140.6,1.0671633798938238,0.09378106587048458,0.1606117338245622,0.7942227296108412,0.32564435671310876,0.4872564435749368,3851]
["High","O00159-3","Isoform 3 of Unconventional myosin-Ic [OS=Homo sapiens]",19,17,24,17,1044,119.6,9.45,43.63,"","","","MYO1C","","","","",1234.2,1237.1,1153.4,1322.1,1346.8,1310.5,0.9108659596924161,-0.134689327923583,0.01592330331903754,1.7979668320497895,0.07785169211962749,1.108731943529637,1597]
["High","O00161","Synaptosomal-associated protein 23 [OS=Homo sapiens]",67,13,35,13,211,23.3,5.01,82.87,"cell-cell signaling;cell organization and biogenesis;stress response;transport","plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP23","ENSG00000092531","Insulin signaling","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding","SNARE interactions in vesicular transport; Platelet activation",1227.1,1360.5,1319.4,1392.4,1305.7,1306.3,0.975676755568874,-0.03552483683244058,0.5425642875957063,0.2655487955551544,0.7025442715667122,0.15332630303667039,6030]
["High","O00165","HCLS1-associated protein X-1 [OS=Homo sapiens]",28,6,14,6,279,31.6,4.92,39.84,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HAX1","ENSG00000143575","","","",554.1,535.6,562.3,746.6,682.2,698.6,0.776534737237943,-0.36487763180733085,1.6149116666025031E-3,2.791851227980726,0.02632407159255187,1.5796469367366541,479]
["High","O00170","AH receptor-interacting protein [OS=Homo sapiens]",32,8,21,8,330,37.6,6.29,43.43,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","AIP","ENSG00000110711","Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway","Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Cushing syndrome; Chemical carcinogenesis",780.9,713.6,784.4,851.4,767.7,742,0.9651857185210284,-0.051121526175100324,0.53358232722321,0.272798563118013,0.6955276812952961,0.15768558084868897,5990]
["High","O00178","GTP-binding protein 1 [OS=Homo sapiens]",29,15,40,15,669,72.4,8.34,104.63,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;other cytoplasmic organelle","nucleic acid binding activity;other molecular function","GTPBP1","ENSG00000100226","","","",1279.4,1374.9,1314.5,1233.9,1408.1,1317.5,1.0023487814117946,0.003384602003974064,0.9596001511574515,0.017909692293575582,0.9782684397750857,0.009541957158852903,7659]
["High","O00180","potassium channel subfamily K member 1 [OS=Homo sapiens]",12,2,2,2,336,38.1,6.37,7.92,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","KCNK1","ENSG00000135750","","Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK); Phase 4 - resting membrane potential","",34.5,48.6,31.1,43.4,43.1,32.7,0.9580536912751677,-0.06182158509931891,0.8076623509408449,0.09277016121886784,0.8897048019393506,0.05075406543922677,7088]
["High","O00186","syntaxin-binding protein 3 [OS=Homo sapiens]",23,13,30,13,592,67.7,7.8,52.2,"cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STXBP3","ENSG00000116266","Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation","",1012.2,1022.6,1026.5,1077.7,1072.8,1093.8,0.9435933791572912,-0.08376279912733872,1.3372758667486524E-3,2.8737789928514856,0.02433904421345799,1.6136964803775744,429]
["High","O00189","AP-4 complex subunit mu-1 [OS=Homo sapiens]",8,3,4,3,453,49.9,7.2,3.41,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","AP4M1","ENSG00000221838","","Lysosome Vesicle Biogenesis","Lysosome",266.6,271.8,262.7,264.4,294.3,262.5,0.9755236239649294,-0.03575128431408835,0.5627156630601711,0.24971099619143156,0.7168679877914531,0.14456081288490616,6129]
["High","O00192","armadillo repeat protein deleted in velo-cardio-facial syndrome [OS=Homo sapiens]",19,13,19,13,962,104.6,6.81,45.39,"cell adhesion;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","ARVCF","ENSG00000099889","22q11.2 copy number variation syndrome","","",823.9,745.2,744,684.6,618.1,656.2,1.180815763949155,0.23978388669003106,0.02256774510089288,1.646511832112387,0.09473599663858688,1.0234849716716679,1860]
["High","O00193","Small acidic protein [OS=Homo sapiens]",31,7,43,7,183,20.3,4.72,97.37,"","","","SMAP","ENSG00000110696","","","",1339.2,1378.4,1376.7,1795.8,1630.7,1591.8,0.8158739015204352,-0.29358190311826227,0.00848934419900374,2.071125857665873,0.055889375637286,1.2526707420354815,1186]
["High","O00203-1","AP-3 complex subunit beta-1 [OS=Homo sapiens]",23,23,56,18,1094,121.2,6.04,99.11,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","AP3B1","ENSG00000132842","","Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions","Lysosome",2548.7,2622.2,2488,2462.5,2727,2615,0.9813440963546672,-0.02716900629054585,0.6023077204633258,0.22018156994724997,0.7474282710390414,0.12643047923986375,6292]
["High","O00213","amyloid-beta A4 precursor protein-binding family B member 1 [OS=Homo sapiens]",9,5,6,5,710,77.2,5.06,9.96,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","APBB1","ENSG00000166313","Alzheimer's disease and miRNA effects; Alzheimer's disease","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks","Alzheimer disease",231.3,225.2,221.2,331.8,276.1,281.6,0.7618887015177065,-0.39234783404028184,0.017098439349873207,1.7670435277756458,0.08140525270964025,1.0893475711647083,1640]
["High","O00214-1","Galectin-8 [OS=Homo sapiens]",7,2,2,2,317,35.8,8.25,3.31,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","LGALS8","ENSG00000116977","","","",26.8,40.2,33.7,29.3,48.8,38.4,0.8643776824034335,-0.21026627153485788,0.48389870302674237,0.31524554191097476,0.6575497865006621,0.18207135890826803,5746]
["High","O00217","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [OS=Homo sapiens]",16,3,5,3,210,23.7,6.34,9.73,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS8","ENSG00000110717","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",127.1,117.6,126.5,141.8,118.3,103,1.0223079041586338,0.031829780327364686,0.828734555651987,0.08158455205035957,0.9024769052344093,0.044563903059524276,7170]
["High","O00220","Tumor necrosis factor receptor superfamily member 10A [OS=Homo sapiens]",7,3,5,3,468,50.1,7.03,2.26,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TNFRSF10A","ENSG00000104689","Apoptosis modulation and signaling","Cell surface interactions at the vascular wall; Regulation by c-FLIP; RIPK1-mediated regulated necrosis; CASP8 activity is inhibited; TP53 Regulates Transcription of Death Receptors and Ligands; Dimerization of procaspase-8; TRAIL  signaling","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; p53 signaling pathway; Apoptosis; Necroptosis; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Salmonella infection; Influenza A; Lipid and atherosclerosis",141.6,108.1,141.5,167.5,164.6,155.6,0.8021324584785728,-0.318087602083634,0.051554150988866586,1.2877363608560977,0.15632419841594963,0.805973789574672,2575]
["High","O00221","NF-kappa-B inhibitor epsilon [OS=Homo sapiens]",9,3,8,3,500,52.8,6.68,10.8,"other biological processes","cytosol;nucleus;other cell component","","NFKBIE","ENSG00000146232","TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19","Activation of NF-kappaB in B cells","Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Epstein-Barr virus infection; PD-L1 expression and PD-1 checkpoint pathway in cancer",188,149.1,167.9,164.8,125.5,143.7,1.1635944700460832,0.21858834519467807,0.21252049117800298,0.6725991890184183,0.3900705207141155,0.40885686992649306,4254]
["High","O00231","26S proteasome non-ATPase regulatory subunit 11 [OS=Homo sapiens]",60,23,74,23,422,47.4,6.48,164.89,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD11","ENSG00000108671","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling pathway","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",3744.5,3801.5,3760.4,3495.4,3543,3551.2,1.0676890534108938,0.09449154738171194,6.0089516157387824E-4,3.221201292925063,0.017376997857662373,1.7600252524254152,270]
["High","O00232-1","26s proteasome non-atpase regulatory subunit 12 [OS=Homo sapiens]",51,20,144,20,456,52.9,7.65,244.33,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","","PSMD12","ENSCANG00000030312; ENSCATG00000032968; ENSCSAG00000004164; ENSG00000197170; ENSMFAG00000032701; ENSMLEG00000034943; ENSMMUG00000002132; ENSMNEG00000032475; ENSNLEG00000001265; ENSPANG00000020562; ENSPPYG00000008565; ENSRROG00000042400","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease","Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",4391.8,4759,4000.5,3854.9,4510.4,4193.6,1.0471697362030112,0.06649530829652851,0.532558326964991,0.27363282039282427,0.6944247523284318,0.15837480740520357,5988]
["High","O00233-1","26S proteasome non-ATPase regulatory subunit 9 [OS=Homo sapiens]",33,7,19,7,223,24.7,6.95,43.16,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMD9","ENSG00000110801","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",715.5,666,741.5,734.2,585.2,563.8,1.1273364485981308,0.1729181457542957,0.24012456628192366,0.619563406561431,0.42189302734681816,0.3747976521716257,4444]
["Medium","O00244","Copper transport protein ATOX1 [OS=Homo sapiens]",12,1,3,1,68,7.4,7.24,6.45,"stress response;transport;other biological processes","cytosol","other molecular function","ATOX1","ENSG00000177556","Copper homeostasis","Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface","Mineral absorption",171.1,193.8,180.4,163.2,177.2,150.1,1.111722731906218,0.15279701901267198,0.14867894160996134,0.8277505391460557,0.3092395247977033,0.5097050027727478,3754]
["High","O00255-2","Isoform 2 of Menin [OS=Homo sapiens]",26,12,20,12,610,67.5,6.55,48.24,"","","","MEN1","","","","",778.4,763.3,720.8,651.7,655.2,683.1,1.136934673366834,0.1851493614269186,0.010304863622433222,1.9869577514264107,0.06179752316740292,1.2090289309999485,1302]
["High","O00258-1","Tail-anchored protein insertion receptor WRB [OS=Homo sapiens]",13,2,2,2,174,19.8,9.67,2.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus","","GET1; WRB","ENSANAG00000014374; ENSCANG00000035340; ENSCATG00000041953; ENSCCAG00000026562; ENSCSAG00000008355; ENSG00000182093; ENSMLEG00000038301; ENSMNEG00000036276; ENSNLEG00000033928; ENSPANG00000032093; ENSPPAG00000034665; ENSPPYG00000011427; ENSPTRG00000013915; ENSSBOG00000020756","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",19.6,23.3,21.4,21.8,22.1,26.9,0.9081920903954802,-0.13893062275505014,0.3326111827588521,0.4780631534062811,0.5199255485447682,0.28405884130964676,4995]
["High","O00264","Membrane-associated progesterone receptor component 1 [OS=Homo sapiens]",69,19,142,17,195,21.7,4.7,283.11,"other metabolic processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PGRMC1","ENSG00000101856","","Neutrophil degranulation","",6126.2,5545.5,6179.1,5674.1,5034.1,5108.3,1.1286188474061898,0.17455834722760027,0.07703293700770068,1.113323543630143,0.2029261714426879,0.6926619382787981,2964]
["High","O00267","Transcription elongation factor Spt5 [OS=Homo sapiens]",34,28,82,28,1087,120.9,5.06,189.56,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SUPT5H","ENSG00000196235","Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","",2951.1,2943.4,2931.7,3172.1,3275.1,3277.1,0.9076437378525963,-0.13980196311084514,0.001040071029432036,2.9829370004733127,0.021483795232289254,1.6678889956519025,378]
["High","O00268","Transcription initiation factor TFIID subunit 4 [OS=Homo sapiens]",10,7,11,7,1085,110,9.94,32.34,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","TAF4","ENSG00000130699","","RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors; Huntington disease",355.8,365.4,346.7,348.2,320.8,347.9,1.0501524240338285,0.07059874259443208,0.18294822646836367,0.73767179628252,0.35366668785961464,0.4514058447938729,4039]
["High","O00273-1","DNA fragmentation factor subunit alpha [OS=Homo sapiens]",56,13,36,4,331,36.5,4.79,78.92,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DFFA","ENSG00000160049","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis","Apoptosis induced DNA fragmentation","Apoptosis",749.9,704.6,742.9,744.4,711.5,761.7,0.9908910533910532,-0.013201650364373546,0.757585773014986,0.12056818970581443,0.858274770124929,0.06637365382316988,6892]
["High","O00291","Huntingtin-interacting protein 1 [OS=Homo sapiens]",38,32,79,31,1037,116.1,5.3,156.45,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HIP1","ENSG00000127946","","Clathrin-mediated endocytosis; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","Huntington disease; Pathways of neurodegeneration",3560.6,3426.8,3526.3,3797.6,3702.9,3812.3,0.929363199207977,-0.1056855765411021,0.007244766797229963,2.139975589531138,0.05147146419724436,1.2884334772959931,1099]
["High","O00299","chloride intracellular channel protein 1 [OS=Homo sapiens]",87,18,146,17,241,26.9,5.17,373.46,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion;nucleus;other cell component","transporter activity","CLIC1","ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685","VEGFA-VEGFR2 signaling pathway","","",5441.8,5666.5,5588.9,5656.5,5913.6,5562.1,0.9746092153955708,-0.037104230922048384,0.3071475069055432,0.5126530054675164,0.4943738886659414,0.3059444754349444,4851]
["Medium","O00300","Tumor necrosis factor receptor superfamily member 11B [OS=Homo sapiens]",2,1,1,1,401,46,8.29,2.13,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","TNFRSF11B","ENSG00000164761","Osteoclast signaling; RANKL/RANK signaling pathway; Ectoderm differentiation; Vitamin D receptor pathway; Osteoblast signaling; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Overlap between signal transduction pathways contributing to LMNA laminopathies; Monoamine transport","TNFs bind their physiological receptors","Cytokine-cytokine receptor interaction; Osteoclast differentiation",101.2,93.1,84.4,103.7,118.2,107.3,0.8465978128797086,-0.24025133331781623,0.061251677563655155,1.2128820123240582,0.17391021760618888,0.7596749014956855,2750]
["High","O00303","Eukaryotic translation initiation factor 3 subunit F [OS=Homo sapiens]",42,11,55,11,357,37.5,5.45,110.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3F","ENSG00000175390","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",2147.4,2211.2,2142.3,2060.7,2239.1,2138.9,1.0096603351608244,0.013870030405803086,0.7308254837444155,0.13618631729019534,0.8387895600582678,0.07634698359212737,6803]
["High","O00308","NEDD4-like E3 ubiquitin-protein ligase WWP2 [OS=Homo sapiens]",14,10,14,9,870,98.9,7.12,23.19,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","WWP2","ENSG00000198373","","RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle","Ubiquitin mediated proteolysis",419.8,427.9,421.7,474.3,481.6,440.9,0.9087915234822451,-0.1379787163466603,0.029192293255231556,1.5347317868560297,0.1101127660564483,0.9581623276543121,2070]
["High","O00311-1","Cell division cycle 7-related protein kinase [OS=Homo sapiens]",5,2,5,2,574,63.8,8.73,10.07,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CDC7","ENSG00000097046","Cell cycle; Retinoblastoma gene in cancer; DNA replication","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Transcriptional Regulation by E2F6","Cell cycle",41.3,41.3,37.4,46.7,52.5,46.3,0.8247422680412371,-0.2779847472997654,0.02360258250568446,1.6270404755634893,0.09725011303661438,1.0121098852089452,1895]
["High","O00330-1","Pyruvate dehydrogenase protein X component, mitochondrial [OS=Homo sapiens]",24,11,21,11,501,54.1,8.66,44.04,"other metabolic processes","mitochondrion;other cell component","other molecular function","PDHX","ENSG00000110435","Amino acid metabolism","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Metabolic pathways",833.3,932.5,817.8,868.8,867.3,901.7,0.9794525741147925,-0.029952457163131184,0.6563242076062588,0.18288157709926617,0.7865816443575854,0.10425619248923425,6515]
["Low","O00339-1","Matrilin-2 [OS=Homo sapiens]",1,1,2,1,956,106.8,6.27,3.59,"","non-structural extracellular;extracellular matrix","extracellular structural activity;other molecular function","MATN2","ENSG00000132561","","","",160.4,150.7,168.2,164.7,171.6,148.3,0.9890631448617417,-0.01586546483238361,0.8466666264738398,0.07228755871648421,0.9128380308627093,0.03960627453884169,7242]
["High","O00391","Sulfhydryl oxidase 1 [OS=Homo sapiens]",3,2,2,2,747,82.5,8.92,3.63,"cell organization and biogenesis;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","QSOX1","ENSG00000116260","","Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",175.8,176.9,180.8,134.4,154.5,138.7,1.247661365762395,0.3192264179912969,0.004971054230491147,2.3035514990065273,0.04274668659876088,1.369097542868977,908]
["High","O00399","Dynactin subunit 6 [OS=Homo sapiens]",22,4,8,4,190,20.7,6.32,12.06,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","DCTN6","ENSG00000104671","","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","Vasopressin-regulated water reabsorption; Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection",414.2,419.8,414.1,470.6,444.7,457.9,0.9088989222254588,-0.13780823227465763,0.005661834908388855,2.247042798238495,0.045858513448859106,1.3385800274826904,964]
["High","O00400","Acetyl-coenzyme A transporter 1 [OS=Homo sapiens]",12,6,10,6,549,60.9,7.33,16.81,"transport;signal transduction","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC33A1","ENSG00000169359","Ganglio sphingolipid metabolism","Transport of vitamins, nucleosides, and related molecules; Defective SLC33A1 causes spastic paraplegia 42 (SPG42)","Glycosphingolipid biosynthesis; Metabolic pathways",411.7,398.4,384.3,382.2,399.6,376.2,1.031433506044905,0.0446508172579422,0.3151745506778626,0.5014488576367564,0.5023235133073588,0.29901649243445166,4899]
["High","O00401","Neural Wiskott-Aldrich syndrome protein [OS=Homo sapiens]",30,10,24,10,505,54.8,7.93,39.06,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity","WASL","ENSG00000106299","Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 signaling pathway","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle; RHOV GTPase cycle; NOSTRIN mediated eNOS trafficking; Nephrin family interactions; EPHB-mediated forward signaling; DCC mediated attractive signaling","Endocytosis; Adherens junction; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",755,744.9,787.3,892.9,804.1,819,0.9090620031796502,-0.13754939713555345,0.06548846500739786,1.1838351889364378,0.18235874992074266,0.7390733935724234,2804]
["High","O00410","Importin-5 [OS=Homo sapiens]",64,47,286,44,1097,123.6,4.94,616.8,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","IPO5","ENSG00000065150","","vRNP Assembly","Nucleocytoplasmic transport",8232,8404.7,8311,8759.2,8957.6,8917.8,0.9366650897704488,-0.09439479908164711,2.0115329577220383E-3,2.6964728473882413,0.028977950800541837,1.5379323292679927,542]
["High","O00411","DNA-directed RNA polymerase, mitochondrial [OS=Homo sapiens]",17,16,27,16,1230,138.5,8.98,50.34,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","POLRMT","ENSG00000099821","Mitochondrial gene expression","Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis","",642.9,625.7,615.6,582.7,660.3,615.7,1.0137192661537633,0.019658175611783527,0.739600811387275,0.13100262106502394,0.8464970881430436,0.07237453147776693,6822]
["High","O00418","Eukaryotic elongation factor 2 kinase [OS=Homo sapiens]",10,7,10,7,725,82.1,5.33,18.04,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;kinase activity;other molecular function","EEF2K","ENSG00000103319","Translation factors; AMP-activated protein kinase (AMPK) signaling; BDNF-TrkB signaling","mTORC1-mediated signalling","AMPK signaling pathway; Oxytocin signaling pathway",353.3,308.2,310.8,368.9,357.8,368.5,0.8877830533235938,-0.1717209252189031,0.053018286501974904,1.2755743123396703,0.15854721601203373,0.7998413795039794,2611]
["High","O00422","Histone deacetylase complex subunit SAP18 [OS=Homo sapiens]",60,10,53,10,153,17.6,9.35,91.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SAP18","ENSG00000150459","Hedgehog signaling pathway","Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression","Nucleocytoplasmic transport; mRNA surveillance pathway",3771.6,3625.7,3732.3,3877.3,3810.1,3792.1,0.9695195783788492,-0.04465806262555996,0.08295354805319397,1.0811650337870609,0.21334035019741054,0.6709269963518684,3036]
["High","O00423-1","Echinoderm microtubule-associated protein-like 1 [OS=Homo sapiens]",5,4,7,4,815,89.8,7.06,15.94,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","EML1","ENSG00000066629","","","",182.9,181.9,176.4,184.5,206.8,199.1,0.9166666666666667,-0.12553088208385882,0.07467180058051577,1.1268433762898764,0.19844704524597248,0.7023553630854787,2938]
["High","O00425","Insulin-like growth factor 2 mRNA-binding protein 3 [OS=Homo sapiens]",56,30,200,24,579,63.7,8.87,408.36,"protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP3","ENSG00000136231","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",7893.5,7810.7,8046.4,8854.6,9176.2,9095.9,0.8755432839232192,-0.1917495924617616,6.9205558227454207E-4,3.1598590238875524,0.018442218383616465,1.7341868395830264,293]
["High","O00429","Dynamin-1-like protein [OS=Homo sapiens]",73,46,289,1,736,81.8,6.81,653.37,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","DNM1L","ENSG00000087470","Synaptic vesicle pathway; CAMKK2 pathway","Apoptotic execution phase","Necroptosis; NOD-like receptor signaling pathway; TNF signaling pathway",79.9,85.1,83.5,88.2,97.8,104.9,0.8542454451701617,-0.22727744465065775,0.049633645963110234,1.304223821447821,0.15257460932282074,0.8165177334091237,2540]
["High","O00429-6","Isoform 6 of Dynamin-1-like protein [OS=Homo sapiens]",71,46,287,0,749,83.3,7.08,646.88,"","","","DNM1L","","","","",10625,10377.7,10252.5,10282.3,10316.3,10517.7,1.0044638983426692,0.006425712784033878,0.7431083776019347,0.12894784254891736,0.8490181756388507,0.07108301235302598,6834]
["High","O00429-8","Isoform 8 of Dynamin-1-like protein [OS=Homo sapiens]",72,46,285,1,738,82,6.96,642.25,"","","","DNM1L","","","","",178.5,215.5,196.8,172.6,214.5,194.9,1.0151202749140893,0.021650672969142956,0.8646460562135085,0.06316163506808214,0.9225411870613658,0.035014235560035425,7318]
["High","O00442","RNA 3'-terminal phosphate cyclase [OS=Homo sapiens]",44,14,50,14,366,39.3,7.85,106.23,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RTCA","ENSG00000137996","","","",1668.4,1642.7,1681.2,1698.9,1737.8,1758,0.9610372110035229,-0.057335802191228614,0.031151054463110485,1.5065272478889398,0.11445996858727843,0.9413463776166348,2125]
["High","O00443","phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [OS=Homo sapiens]",15,23,41,23,1686,190.6,8.02,76.67,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2A","ENSG00000011405","Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection",1735.7,1833.3,1785.5,2047.1,1971.5,1967.8,0.8944440732326607,-0.16093681696159134,0.005294789939166829,2.276151265031537,0.04431052502145188,1.3534931041194016,933]
["High","O00458","Interferon-related developmental regulator 1 [OS=Homo sapiens]",11,3,3,3,451,50.2,7.18,9.27,"other biological processes","nucleus","","IFRD1","ENSG00000006652","Hypertrophy model","","",20.8,22.8,24.1,39.4,32.3,33.3,0.6447619047619049,-0.633161588978488,0.006777224675140874,2.1689481166092732,0.05011038850710222,1.3000722301484313,1056]
["High","O00459","Phosphatidylinositol 3-kinase regulatory subunit beta [OS=Homo sapiens]",16,7,14,7,728,81.5,6.43,30.92,"other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R2","ENSG00000105647","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway","Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOU GTPase cycle; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",394.5,386,377.9,396.6,400.4,406.5,0.9625259659326963,-0.0551026342786538,0.054779632572612064,1.261380885047049,0.16170864692890546,0.7912667567596181,2645]
["High","O00461","Golgi integral membrane protein 4 [OS=Homo sapiens]",32,17,34,17,696,81.8,4.77,79.63,"","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","GOLIM4","ENSG00000173905","","Intra-Golgi traffic","",1271.8,1196.3,1273,1261.9,1231.9,1193.5,1.0145906218642367,0.020897730422525712,0.607024807409313,0.21679356015896648,0.7505383525339534,0.12462711039168063,6315]
["High","O00462","Beta-mannosidase [OS=Homo sapiens]",8,7,11,6,879,100.8,5.52,16.56,"protein metabolism;other metabolic processes","plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","MANBA","ENSG00000109323","","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","Other glycan degradation; Lysosome",257.2,341.2,287.5,260.6,279.6,292.4,1.0640163343742493,0.08952029871489207,0.5354927009054974,0.27124644449238605,0.6972031029965188,0.1566406886715301,5997]
["High","O00463","TNF receptor-associated factor 5 [OS=Homo sapiens]",4,2,4,2,557,64.4,7.43,1.67,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","signal transduction activity or receptor binding;other molecular function","TRAF5","ENSG00000082512","RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Small cell lung cancer; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling","","NF-kappa B signaling pathway; Necroptosis; NOD-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Shigellosis; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Small cell lung cancer",20.9,22.8,30.8,30.9,29.2,26.8,0.857307249712313,-0.2221157514648763,0.27338200549946284,0.5632300748796747,0.45727649934443143,0.3398211175943718,4668]
["High","O00468","Agrin [OS=Homo sapiens]",18,26,37,26,2067,217.1,6.39,78.62,"","","","","","","","",1330.9,1239.7,1399.4,1385.7,1285.8,1387.8,0.9780011332003055,-0.03209195807231356,0.6302891029551069,0.2004602013106473,0.7666766343470127,0.1153877723362898,6419]
["High","O00469-1","procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [OS=Homo sapiens]",13,7,15,7,737,84.6,6.71,30.91,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","PLOD2","ENSG00000152952","Clear cell renal cell carcinoma pathways; Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","Lysine degradation; Metabolic pathways",752.3,716.1,729.7,638.9,696.8,662.7,1.0999299439551644,0.13741163945263674,0.028447865766602687,1.5459503099562695,0.10845748823517275,0.9647404576014272,2048]
["High","O00471","Exocyst complex component 5 [OS=Homo sapiens]",20,15,29,15,708,81.8,6.71,45.03,"cell organization and biogenesis;transport;other biological processes","cytosol;other cell component","other molecular function","EXOC5","ENSG00000070367","Ciliary landscape","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium","Salmonella infection",1263.8,1365.7,1284,1355.9,1351.7,1366,0.960698153967007,-0.05784487947538746,0.16483698620097215,0.7829453345032654,0.33086045970621863,0.48035513117033773,3890]
["High","O00483","Cytochrome c oxidase subunit NDUFA4 [OS=Homo sapiens]",56,5,13,5,81,9.4,9.38,22.67,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NDUFA4","ENSG00000189043","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; Oxidative phosphorylation","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",630.2,622,686.6,518.8,593.4,600.4,1.1320798785472383,0.17897575703750657,0.08483326832369642,1.071433800856363,0.21625143946177658,0.6650409930043003,3063]
["High","O00487","26S proteasome non-ATPase regulatory subunit 14 [OS=Homo sapiens]",41,12,33,12,310,34.6,6.52,69.71,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMD14","ENSG00000115233","Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Metalloprotease DUBs","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",1681,1804.7,1769.6,1671.6,1828.8,1808.4,0.9899223930078361,-0.014612668292500372,0.7864679285549923,0.10431898281257539,0.876247372453964,0.057373271313964296,7008]
["High","O00499","Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",35,15,33,1,593,64.7,5.06,96.43,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","BIN1","ENSG00000136717","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway","Clathrin-mediated endocytosis","Endocytosis; Fc gamma R-mediated phagocytosis",1543.1,1403.1,1495.3,1855.3,1753.5,1732.3,{"$f":"AVERAGE(T130:V130)/AVERAGE(W130:Y130)","v":0.8315702757858867},{"$f":"LOG(Z130,2)","v":-0.2660899044432507},{"$f":"TTEST(T130:V130,W130:Y130,2,2)","v":0.005844388970836036},{"$f":"-LOG10(AB130)","v":2.233260887490286},{"$f":"AB130*7808/AF130","v":0.046707255971635386},{"$f":"-LOG10(AD130)","v":1.3306156465504237},977]
["High","O00499-2","Isoform IIB of Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",39,15,35,1,518,56.5,5.12,96.18,"","","","BIN1","","","","",248.6,238.1,236.4,283.5,265.6,281.5,0.8705754875993258,-0.19995869550213138,0.006305945376478751,2.2002497955285847,0.04870110929727605,1.3124611464609501,1011]
["High","O00505","Importin subunit alpha-4 [OS=Homo sapiens]",34,14,51,10,521,57.8,4.94,112.11,"cell organization and biogenesis;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","KPNA3","ENSG00000102753","","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis",1202.5,1103.9,1171.6,1120.9,1134.3,1132.4,1.0266855590978863,0.0379943980231002,0.3635595897921046,0.43942439526749666,0.547689229615426,0.26146579944839243,5183]
["High","O00506","serine/threonine-protein kinase 25 [OS=Homo sapiens]",19,6,24,2,426,48.1,6.74,36.62,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","kinase activity;other molecular function","STK25","ENSG00000115694","","","",60.3,66.5,47.9,58.1,53.1,60.4,1.018065268065268,0.025830055417213806,0.8689761997227048,0.06099211822411371,0.9243823116396293,0.034148373481548866,7340]
["High","O00507-1","Probable ubiquitin carboxyl-terminal hydrolase FAF-Y [OS=Homo sapiens]",14,31,68,5,2555,290.9,5.86,132.56,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","USP9Y","ENSG00000114374","","","",64.9,54,56.9,78.7,83.5,81.3,0.7219712525667351,-0.4699867018263005,3.1134587629124597E-3,2.506756882040917,0.034095211810407415,1.4673066072341472,713]
["High","O00515","Ladinin-1 [OS=Homo sapiens]",14,6,8,6,517,57.1,9.67,18.53,"","extracellular matrix;cytoskeleton","other molecular function","LAD1","ENSG00000159166","","","",389.1,382.9,369.7,511.1,401.9,409.8,0.8630934381614757,-0.21241134142162635,0.16536873554135806,0.7815465943318838,0.3314166034668696,0.47962573787982626,3896]
["High","O00522","Krev interaction trapped protein 1 [OS=Homo sapiens]",1,1,1,1,736,84.3,8.41,3.49,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","KRIT1","ENSG00000001631","","","Rap1 signaling pathway",89.4,72.8,96.6,94.1,96.4,104.6,0.8769908505591323,-0.18936630343949998,0.19273648397158238,0.7150360679715563,0.3666877355872601,0.43570361541668073,4104]
["High","O00534","von Willebrand factor A domain-containing protein 5A [OS=Homo sapiens]",10,6,8,6,786,86.4,6.58,19.04,"","nucleus","","VWA5A","ENSG00000110002","","","",312.5,319.8,316.4,247.7,275.1,271.1,1.1949867741529159,0.25699465086745416,4.225722156918384E-3,2.374099061397289,0.03913931032173042,1.4073868313633964,843]
["High","O00541-1","Pescadillo homolog [OS=Homo sapiens]",35,19,77,19,588,68,7.33,173.63,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PES1","ENSG00000100029","","Major pathway of rRNA processing in the nucleolus and cytosol","",4204.4,4378.9,4461.6,4460.2,4686.2,4639.3,0.9462631567493852,-0.07968664056031621,0.07346418699276484,1.1339243232540757,0.19671068999983124,0.7061720382413772,2916]
["Medium","O00559","Receptor-binding cancer antigen expressed on SiSo cells [OS=Homo sapiens]",8,1,1,1,213,24.4,6.29,2.55,"other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","EBAG9","ENSG00000147654","","Estrogen-dependent gene expression","Estrogen signaling pathway",14.3,16.5,19.8,23.7,20.2,21.4,0.7748851454823891,-0.3679456068521205,0.061369894882726934,1.2120446205956632,0.17399278839663468,0.7594687518579326,2754]
["High","O00560-1","Syntenin-1 [OS=Homo sapiens]",40,7,14,7,298,32.4,7.53,38.76,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SDCBP","ENSG00000137575; ENSPPAG00000038846; ENSPTRG00000020277","Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling pathway","Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death","",504.2,573.8,476.8,389.1,386.7,419,1.3013056578506863,0.3799598700284067,0.017381328867303394,1.7599170231879848,0.08200206392501806,1.086175216641087,1655]
["High","O00562","Membrane-associated phosphatidylinositol transfer protein 1 [OS=Homo sapiens]",8,7,7,6,1244,134.8,5.95,14.49,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","PITPNM1","ENSG00000110697","","Synthesis of PI","",389.9,381.1,366,390.7,389.6,367.5,0.9905906952430737,-0.013639025287658247,0.7440030061190233,0.12842530969838709,0.8495430640212538,0.07081460150032755,6838]
["High","O00566","U3 small nucleolar ribonucleoprotein protein Mpp10 [OS=Homo sapiens]",24,16,43,16,681,78.8,4.86,96.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","MPHOSPH10","ENSG00000124383","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1164.5,1202.5,1160.2,1363.4,1325.9,1368.7,0.8691966485953672,-0.20224548302827372,7.4442663020414263E-4,3.128178099345883,0.018689656362167028,1.7283986837140854,311]
["High","O00567","Nucleolar protein 56 [OS=Homo sapiens]",61,28,124,28,594,66,9.19,275.69,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP56","ENSG00000101361","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","Ribosome biogenesis in eukaryotes; Spinocerebellar ataxia",5142.4,5120.3,5081.2,4958,5241.8,5392.4,0.984075371018843,-0.02315927807196425,0.5548830637896076,0.25579853057413177,0.7114165783364953,0.14787601854837173,6090]
["High","O00571","ATP-dependent RNA helicase DDX3X [OS=Homo sapiens]",66,41,252,13,662,73.2,7.18,546.44,"cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","DDX3X","ENSG00000215301","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Hepatitis B infection","Neutrophil degranulation","RIG-I-like receptor signaling pathway; Hepatitis B; Viral carcinogenesis",13547.6,13466.6,13484.3,14661.8,14809,15023.9,0.9101870559864433,-0.13576502538740412,2.48040474594479E-4,3.6054774463560246,0.012825827984329085,1.8919145889905589,151]
["High","O00592","Podocalyxin [OS=Homo sapiens]",22,10,69,10,558,58.6,5.49,125.4,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","","PODXL","ENSG00000128567","Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Malignant pleural mesothelioma","","Salmonella infection",4137.7,3633.5,3804.5,3975.4,3680.7,3931,0.9990161472672197,-1.4200981568804583E-3,0.9836370562225617,7.1651185975783035E-3,0.9917662880921696,0.003590658239280177,7744]
["High","O00622","Protein CYR61 [OS=Homo sapiens]",23,8,17,8,381,42,8.21,29.16,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi","signal transduction activity or receptor binding;other molecular function","CCN1","ENSG00000142871","Oncostatin M signaling pathway; VEGFA-VEGFR2 signaling pathway; Hypertrophy model","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",946.9,883.7,917.9,403,410.3,441.8,2.189865349374552,1.130842163999145,2.1796197171338751E-5,4.661619272063713,0.004599586689562513,2.3372811914720724,37]
["High","O00625","Pirin [OS=Homo sapiens]",27,8,29,8,290,32.1,6.92,33.91,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PIR","ENSG00000087842","","Digestion","",1747.2,1803.7,1753.3,1883.2,1843.9,1873.2,0.947127832437548,-0.07836893764408132,0.010000947764097143,1.999958841078663,0.06114909956309357,1.213609933683443,1277]
["High","O00629","Importin subunit alpha-3 [OS=Homo sapiens]",43,16,92,12,521,57.9,4.96,245.96,"transport","other membranes;cytosol;nucleus","other molecular function","KPNA4","ENSG00000186432","Leptin signaling pathway","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis",3683.2,3639.8,3752,3567.3,3593.8,3562.5,1.0327688462829647,0.04651738717625577,0.026375266095561258,1.5788031501491908,0.10379943431156366,0.9838050133087153,1984]
["Low","O00635","E3 ubiquitin-protein ligase TRIM38 [OS=Homo sapiens]",2,1,2,1,465,53.4,7.02,0,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM38","ENSG00000112343","","Interferon gamma signaling","",101.2,79.6,83.1,84.8,86,81.6,1.0455625990491282,0.06427944034371913,0.604119374459165,0.21887723597094857,0.7486056301820601,0.12574691092743998,6301]
["High","O00743","Serine/threonine-protein phosphatase 6 catalytic subunit [OS=Homo sapiens]",31,8,22,8,305,35.1,5.69,47.21,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","cytosol;mitochondrion;nucleus","other molecular function","PPP6C","ENSG00000119414","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",916.2,938.8,935.1,910,1014.3,973.4,0.9628671014942886,-0.054591409223930284,0.31354085802497444,0.5037058575172019,0.5007418734831255,0.3003860901224021,4889]
["High","O00746","Nucleoside diphosphate kinase, mitochondrial [OS=Homo sapiens]",34,6,16,6,187,20.6,10.29,30.44,"other metabolic processes;transport","other membranes;mitochondrion","kinase activity;other molecular function","NME4","ENSG00000103202","Pyrimidine metabolism","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",927.2,1039.5,1000.3,909.8,1007.6,992.8,1.0195175589306578,0.027886622793486096,0.6944503332249801,0.15835880936142,0.8143989489066753,0.08916279552343319,6658]
["High","O00750","Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [OS=Homo sapiens]",2,3,4,3,1634,184.7,7.3,10.18,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2B","ENSG00000133056","Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)","Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection",116.2,114.2,124.1,102.4,120.3,115.9,1.0469580626107502,0.06620365423123682,0.4391421902972458,0.3573948363343054,0.6197039981639066,0.20781570188982246,5533]
["High","O00754","Lysosomal alpha-mannosidase [OS=Homo sapiens]",9,8,12,8,1011,113.7,7.28,23.14,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MAN2B1","ENSG00000104774","","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","Other glycan degradation; Lysosome",735.6,691.8,717.9,626.3,597.1,558.6,1.203872053872054,0.2676820722863189,0.006598237337388171,2.1805720670167696,0.04930051400031276,1.307148552805207,1045]
["High","O00762","Ubiquitin-conjugating enzyme E2 C [OS=Homo sapiens]",23,4,9,4,179,19.6,7.37,12.57,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","UBE2C","ENSG00000175063","Gastric cancer network 1; Gastric cancer network 2","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Ubiquitin mediated proteolysis",621.9,552.5,595.6,512.3,437.1,381.8,1.3296274038461537,0.4110220217166298,0.027016869029227324,1.5683649825574248,0.10510598574001342,0.978372550386275,2007]
["High","O00763","Acetyl-CoA carboxylase 2 [OS=Homo sapiens]",3,6,16,1,2458,276.4,6.49,36.48,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","ACACB","ENSG00000076555","AMP-activated protein kinase (AMPK) signaling; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; IL-18 signaling pathway; 7q11.23 copy number variation syndrome","ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP)","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; AMPK signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Glucagon signaling pathway; Insulin resistance; Alcoholic liver disease",59.5,54.5,51.1,47.5,52.8,48.9,1.10656836461126,0.14609258465802027,0.14261518006460583,0.845834245399867,0.3011193417913581,0.5212613475643858,3698]
["High","O00764-1","Pyridoxal kinase [OS=Homo sapiens]",40,11,42,11,312,35.1,6.13,76.73,"other metabolic processes","non-structural extracellular;nucleus;other cell component","kinase activity;other molecular function","HEL-S-1a; PDXK","ENSG00000160209","","Neutrophil degranulation; Vitamins B6 activation to pyridoxal phosphate","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors",1009.7,1001.9,981.4,992.4,961.7,949.1,1.030931386056765,0.04394831690612922,0.12349799029533795,0.9083401096978101,0.2759005173751069,0.559247485120875,3495]
["High","O00767","acyl-CoA desaturase [OS=Homo sapiens]",11,3,19,3,359,41.5,9,30.34,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","SCD","ENSG00000099194","Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Adipogenesis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; AMPK signaling pathway; Alcoholic liver disease",792,790.4,816.6,987.5,814.8,1002.5,0.8553194523673702,-0.22546474357874127,0.09019263580878885,1.0448289209743566,0.22434663918286823,0.6490804320157636,3139]
["High","O14494","Phospholipid phosphatase 1 [OS=Homo sapiens]",11,2,2,2,284,32.1,7.97,6.23,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","PLPP1","ENSG00000067113","Androgen receptor signaling pathway; Androgen receptor signaling pathway; Sphingolipid pathway; Triacylglyceride synthesis; Androgen receptor signaling pathway","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",101.6,118.1,87.2,115.4,125.2,117.1,0.857981548783897,-0.22098147252874084,0.1468121399175576,0.8332380310601635,0.30674583582453563,0.5132213242511656,3737]
["High","O14495","Phospholipid phosphatase 3 [OS=Homo sapiens]",10,3,5,3,311,35.1,9.14,8.06,"cell adhesion;cell-cell signaling;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","PLPP3","ENSG00000162407","Triacylglyceride synthesis; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",200.7,199.2,202.2,257.7,268.4,268.4,0.7578351164254247,-0.40004410215210845,6.2979502483802662E-5,4.200800774461504,0.007126723991210597,2.147110060540124,69]
["High","O14497","AT-rich interactive domain-containing protein 1A [OS=Homo sapiens]",28,46,118,45,2285,241.9,6.7,267.26,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ARID1A","ENSG00000117713","Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",4984.8,4904,4944.6,5431.1,5127.7,5232.3,0.9393519134195844,-0.09026235273593025,0.025573423814244933,1.5922111239841494,0.10234612667433339,0.9899285887200321,1951]
["High","O14524-1","Nuclear envelope integral membrane protein 1 [OS=Homo sapiens]",9,5,9,5,444,50.6,6.93,16.27,"cell organization and biogenesis","other membranes;nucleus","","NEMP1","ENSG00000166881","","","",340.9,355.6,349.1,427.9,421.3,427.6,0.8189223057644108,-0.28820151042691294,8.5589894290002237E-5,4.067577510009487,0.007955784459718304,2.099316991412733,84]
["High","O14530","Thioredoxin domain-containing protein 9 [OS=Homo sapiens]",36,7,21,7,226,26.5,5.88,38,"","cytosol;cytoskeleton;nucleus;other cell component","","TXNDC9","ENSG00000115514","","","",736.7,667,751.9,715.7,637.5,653.4,1.0742549586364996,0.1033364364404779,0.23317897831634862,0.632310604910992,0.41369267500432855,0.3833221688153017,4401]
["High","O14531","dihydropyrimidinase-related protein 4 [OS=Homo sapiens]",21,10,33,10,572,61.8,7.09,65.86,"cell organization and biogenesis;developmental processes;other biological processes","cytosol","cytoskeletal activity;other molecular function","DPYSL4","ENSG00000151640","","CRMPs in Sema3A signaling","",934.6,971.9,995.9,915.3,907.5,949.5,1.0469285430869675,0.06616297612530915,0.12011877733468412,0.9203890970483342,0.2705964839668822,0.5676778507675969,3466]
["High","O14545","TRAF-type zinc finger domain-containing protein 1 [OS=Homo sapiens]",6,3,6,3,582,64.8,5.29,11.48,"other biological processes","","other molecular function","TRAFD1","ENSG00000135148","","","",329,313.5,331.9,331.1,285.1,294.4,1.070063694267516,0.09769667388713327,0.233310809814845,0.6320651388994355,0.4137385425923938,0.3832740197003258,4403]
["High","O14548","Cytochrome c oxidase subunit 7A-related protein, mitochondrial [OS=Homo sapiens]",11,1,1,1,114,12.6,9.42,3.4,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity","COX7A2L","ENSG00000115944","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",110.4,107.7,115,107.9,95.5,109.9,1.063198212575806,0.08841058430329736,0.25590455258756795,0.5919219878679064,0.4390469669531379,0.35748901871566396,4551]
["High","O14561","Acyl carrier protein, mitochondrial [OS=Homo sapiens]",13,2,5,2,156,17.4,4.93,6.75,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","NDUFAB1","ENSG00000004779","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",269.3,251.7,275.7,298.8,264.3,225.9,1.0097591888466413,0.014011274679932392,0.913697187565413,0.039197711880067494,0.9527440759229092,0.02102374295148092,7488]
["High","O14562","Ubiquitin domain-containing protein UBFD1 [OS=Homo sapiens]",33,7,35,7,309,33.4,5.77,62.32,"","","","UBFD1","ENSG00000103353","","","",1324.6,1234.2,1440.5,1501.6,1249,1250.2,0.999625074985003,-5.4100388412466169E-4,0.9963612682053978,0.001583163242726206,0.998535333352297,6.3656293305594752E-4,7791]
["High","O14578-4","Isoform 4 of Citron Rho-interacting kinase [OS=Homo sapiens]",19,36,55,36,2069,236.5,6.67,103.88,"","","","CIT","","","","",2581.2,2556.7,2563.9,2334.2,2420.4,2341.1,1.0854179291683694,0.11825064473882939,0.002117018359296834,2.674275375657143,0.02957008828155578,1.5291473788849308,559]
["High","O14579-1","coatomer subunit epsilon [OS=Homo sapiens]",34,12,29,12,308,34.5,5.12,61.56,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","COPE","ENSG00000105669; ENSPTRG00000010723","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",1007.6,1052.7,1036.6,1006.3,1058.7,1036.1,0.9986456418690142,-1.9552501126815663E-3,0.94783754207203,0.02326609370390415,0.9717326061578795,0.01245322442168667,7616]
["High","O14617-5","Isoform 5 of AP-3 complex subunit delta-1 [OS=Homo sapiens]",39,34,102,4,1215,136.6,7.64,215.34,"","","","AP3D1","","","","",3488.5,3607.6,3598.9,3435.4,3664.9,3599.9,0.9995140277751817,-7.0128013389362208E-4,0.9834025041034311,0.007268690171424064,0.9917859405889422,3.5820524957249212E-3,7742]
["High","O14618","copper chaperone for superoxide dismutase [OS=Homo sapiens]",37,9,26,9,274,29,5.58,58.72,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CCS","ENSG00000173992","Amyotrophic lateral sclerosis (ALS); Copper homeostasis","Detoxification of Reactive Oxygen Species","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",1455.2,1322.5,1337.4,1418.4,1392,1396.4,0.9782019587334791,-0.031795741382946205,0.5141912507853478,0.288875317362492,0.6802448807407651,0.1673347178677973,5902]
["High","O14628-1","Zinc finger protein 195 [OS=Homo sapiens]",17,8,12,3,629,72.3,8.09,18.84,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF195","ENSG00000005801","","Generic Transcription Pathway","Herpes simplex virus 1 infection",220.8,213.9,215.6,200.6,216.7,219,1.0220022002200222,0.03139830218854608,0.49016140034474454,0.30966089193608576,0.6623710996697414,0.17889862478562849,5778]
["High","O14639-1","Actin-binding LIM protein 1 [OS=Homo sapiens]",8,5,5,5,778,87.6,8.59,7.43,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ABLIM1","ENSG00000099204","Male infertility","DCC mediated attractive signaling","Axon guidance",158.2,129.8,136.4,213.4,149.2,144,0.837741808132649,-0.2554224207977363,0.3157073356556104,0.5007153268890939,0.502967328463376,0.2984602247430882,4901]
["High","O14641","Segment polarity protein dishevelled homolog DVL-2 [OS=Homo sapiens]",18,12,21,10,736,78.9,6.02,43.31,"cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","DVL2","ENSG00000004975","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)","RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; Degradation of DVL; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",1007,1158.8,1113.2,1051.7,1136.3,1099.4,0.9974447891951086,-3.691107746712574E-3,0.9590138922024831,0.018175101626853943,0.9779261421336017,0.009693944062156934,7657]
["High","O14646","Chromodomain-helicase-DNA-binding protein 1 [OS=Homo sapiens]",21,35,65,30,1710,196.6,7.14,121.56,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD1","ENSG00000153922","","Estrogen-dependent gene expression","",2610.2,2547.6,2524.4,2951.3,2811.6,3032.3,0.8734537020192831,-0.1951968607062644,0.005891148064441435,2.229800061840175,0.046984764133972144,1.3280429489846775,979]
["High","O14647","Chromodomain-helicase-DNA-binding protein 2 [OS=Homo sapiens]",13,23,44,18,1828,211.2,8.1,79.25,"cell organization and biogenesis;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CHD2","ENSG00000173575","Prion disease pathway; Male infertility","","",1463.7,1447.7,1419.3,1670.5,1573.7,1733.9,0.8699503826761213,-0.20099497520003046,0.011136035536074231,1.9532693918592026,0.06469506359052649,1.1891288559183735,1344]
["High","O14653-1","Golgi SNAP receptor complex member 2 [OS=Homo sapiens]",24,4,4,4,212,24.8,8.06,11.17,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","GOSR2","ENSG00000108433","","COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER","SNARE interactions in vesicular transport",226.8,266.3,243.3,224.8,270.8,251.3,0.985941893158388,-0.020425471532122617,0.8518634161562071,0.06963003242200644,0.9160376743351695,0.03808666452056682,7261]
["High","O14656","Torsin-1A [OS=Homo sapiens]",19,5,10,5,332,37.8,6.99,14.35,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TOR1A","ENSG00000136827","","Cargo recognition for clathrin-mediated endocytosis","",307.7,301.8,300.1,299.3,303.9,308.5,0.9976966107272127,-0.003326921351202905,0.8518699678407323,0.0696266922744655,0.915918577375439,0.03814313219270359,7262]
["Low","O14657","Torsin-1B [OS=Homo sapiens]",2,1,2,1,336,38,8.54,4.48,"cell organization and biogenesis;stress response;other biological processes","other membranes;ER/Golgi;nucleus","cytoskeletal activity;other molecular function","TOR1B","ENSG00000136816","","Cargo recognition for clathrin-mediated endocytosis","",171.6,159.9,172.6,146.2,131.4,150.4,1.177803738317757,0.23609915772085494,0.02288696557773665,1.6404117835684446,0.09540919766736133,1.0204097562850465,1873]
["High","O14662-2","Isoform A of Syntaxin-16 [OS=Homo sapiens]",27,6,11,6,304,34.8,6.2,24.64,"","","","STX16","","","","",547.1,553.7,581.1,508,468.4,478.1,1.1563423856995532,0.2095686340104333,0.008708302814469628,2.060066477613642,0.056520721841545184,1.2477923002948514,1203]
["Medium","O14668-1","Transmembrane gamma-carboxyglutamic acid protein 1 [OS=Homo sapiens]",3,1,2,1,218,24.9,5.19,4.45,"","non-structural extracellular;plasma membrane;other membranes","other molecular function","PRRG1","ENSG00000130962; ENSNLEG00000000909","","","",97.2,117.4,127.9,84.7,84.7,83.4,1.3548259493670887,0.43810752455814855,0.029509863703526724,1.5300327963605265,0.11072225650991671,0.955765071913518,2081]
["High","O14672","Disintegrin and metalloproteinase domain-containing protein 10 [OS=Homo sapiens]",28,17,39,17,748,84.1,7.77,86.88,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM10","ENSG00000137845","Alzheimer's disease and miRNA effects; Copper homeostasis; Canonical and non-canonical Notch signaling; VEGFA-VEGFR2 signaling pathway; 3q29 copy number variation syndrome; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Hypertrophy model","Amyloid fiber formation; Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus","Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection",1214.2,1253.4,1251,1402.5,1461.3,1422.4,0.8675750081657412,-0.20493960033114203,9.0778152380667975E-4,3.0420186607542874,0.02036769579851309,1.6910581000422331,348]
["High","O14681","Etoposide-induced protein 2.4 homolog [OS=Homo sapiens]",8,3,3,3,340,38.9,9.72,7.6,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EI24","ENSG00000149547","miRNA regulation of p53 pathway in prostate cancer","","p53 signaling pathway",243.2,275.8,282.2,250.2,254.4,259.3,1.0488283806780991,0.06877862967838493,0.3713087549018967,0.43026481064252453,0.5557176074897469,0.25514584270626406,5217]
["High","O14682","Ectoderm-neural cortex protein 1 [OS=Homo sapiens]",3,2,4,2,589,66.1,6.84,7.6,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity","ENC1","ENSG00000171617","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","",269.5,224.8,228.4,226.9,189.6,188,1.1955334987593051,0.25765455482314087,0.10888921106503763,0.963015148775351,0.2541724843036813,0.5948714662205574,3345]
["High","O14683","Tumor protein p53-inducible protein 11 [OS=Homo sapiens]",18,3,12,3,189,21,9.55,34.84,"other biological processes","other membranes","","TP53I11","ENSG00000175274","","","",422.2,387.5,376.5,363.4,387.5,368.9,1.0592963029112343,0.0831061917373718,0.22852036813512375,0.6410750849837796,0.40867774493794,0.3886190116982646,4366]
["High","O14686-1","Histone-lysine N-methyltransferase 2D [OS=Homo sapiens]",5,20,31,20,5537,593,5.58,54.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KMT2D","ENSG00000167548","Histone modifications; 16p11.2 proximal deletion syndrome","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Lysine degradation; Metabolic pathways; Cushing syndrome",986.2,935.7,940.8,1043.9,1007.9,1040.7,0.9256911883589328,-0.11139710585977292,0.017857490212343518,1.7481795792393358,0.08349178657363963,1.0783562457282838,1670]
["High","O14717-1","tRNA (cytosine(38)-C(5))-methyltransferase [OS=Homo sapiens]",7,2,2,2,391,44.6,6.09,4.6,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT2; TRDMT1","ENSG00000107614","","tRNA modification in the nucleus and cytosol","",16.3,13,14.7,14.5,12.1,16.5,1.0208816705336425,0.029815654435561254,0.8594606711308669,0.06577399181187357,0.9195216388311604,0.03643804618186763,7298]
["High","O14727","apoptotic protease-activating factor 1 [OS=Homo sapiens]",4,5,6,5,1248,141.7,6.4,12.17,"stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;other cell component","enzyme regulator activity;other molecular function","APAF1","ENSG00000120868","miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkinson's disease pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; p53 transcriptional gene network; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response","Neutrophil degranulation; Transcriptional Regulation by E2F6; Formation of apoptosome; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of the apoptosome activity","Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Legionellosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Small cell lung cancer; Lipid and atherosclerosis",270.6,256.3,260.3,274.7,288.6,287.1,0.9256820319849485,-0.11141137619186449,0.026338647719940943,1.5794065263690586,0.10381229752513826,0.9837511972489703,1981]
["High","O14730","serine/threonine-protein kinase RIO3 [OS=Homo sapiens]",8,4,5,4,519,59.1,5.76,6.55,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;other cell component","kinase activity;other molecular function","RIOK3","ENSG00000101782","","Major pathway of rRNA processing in the nucleolus and cytosol","",124.8,126.7,121.1,156.3,170.7,169.8,0.75,-0.4150374992788438,1.1080765617406706E-3,2.955430231310867,0.022241289959051815,1.6528400279779396,389]
["High","O14732-1","inositol monophosphatase 2 [OS=Homo sapiens]",17,4,6,4,288,31.3,6.61,13.79,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA2","ENSG00000141401","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",435.3,429.8,427.2,423.4,430.8,440.3,0.9983005021243723,-0.002453942983758,0.8993300568502357,0.0460808916237193,0.9429258874562427,0.0255224408084533,7447]
["High","O14733","dual specificity mitogen-activated protein kinase kinase 7 [OS=Homo sapiens]",15,5,15,5,419,47.5,9.16,22,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAP2K7","ENSG00000076984","MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; MAPK signaling pathway; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; Alzheimer's disease; ErbB signaling pathway; Toll-like receptor signaling pathway","FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Uptake and function of anthrax toxins","MAPK signaling pathway; ErbB signaling pathway; Protein processing in endoplasmic reticulum; Osteoclast differentiation; Tight junction; Toll-like receptor signaling pathway; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Relaxin signaling pathway; Alcoholic liver disease; Alzheimer disease; Huntington disease; Pathways of neurodegeneration; Salmonella infection; Yersinia infection; Hepatitis B; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Chemical carcinogenesis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",994.1,717,746.4,719.2,743.3,785.6,1.093145322716961,0.1284852056087327,0.4812868068676778,0.3175960431285791,0.6549124064173628,0.18381678237992333,5738]
["High","O14734","Acyl-coenzyme A thioesterase 8 [OS=Homo sapiens]",22,4,5,4,319,35.9,7.56,17.22,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOT8","ENSG00000101473","","Peroxisomal protein import; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids","Primary bile acid biosynthesis; Metabolic pathways; Peroxisome",76,83.2,66.8,69.5,96.1,78.4,0.9262295081967213,-0.11055837514769853,0.5476037751392517,0.26153356653422355,0.7055594515325541,0.15146638604187435,6060]
["High","O14735","CDP-diacylglycerol--inositol 3-phosphatidyltransferase [OS=Homo sapiens]",19,4,6,4,213,23.5,8.03,11.57,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","CDIPT","ENSG00000103502","Glycerolipids and glycerophospholipids; 16p11.2 proximal deletion syndrome","Synthesis of PI","Inositol phosphate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system",520,502.1,469.6,483.9,454.7,449.6,1.0745569802622101,0.1037419862204614,0.1311324287371128,0.882289895037478,0.2869624449493769,0.542174936082928,3568]
["High","O14744","Protein arginine N-methyltransferase 5 [OS=Homo sapiens]",39,22,81,22,637,72.6,6.29,162.25,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","PRMT5","ENSG00000100462","Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis","RMTs methylate histone arginines; snRNP Assembly; Regulation of TP53 Activity through Methylation","",3384,3354.2,3342.3,3411.4,3594.4,3567.6,{"$f":"AVERAGE(T194:V194)/AVERAGE(W194:Y194)","v":0.9533830177615525},{"$f":"LOG(Z194,2)","v":-0.06887216741285174},{"$f":"TTEST(T194:V194,W194:Y194,2,2)","v":0.04813444110741237},{"$f":"-LOG10(AB194)","v":1.3175440664451774},{"$f":"AB194*7808/AF194","v":0.15015330250366593},{"$f":"-LOG10(AD194)","v":0.8234651113947653},2503]
["High","O14745","Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [OS=Homo sapiens]",44,13,23,13,358,38.8,5.77,51.87,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function","SLC9A3R1","ENSG00000109062","","","Tight junction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human papillomavirus infection",938,787.8,966.2,1068.7,764.2,723.6,1.0530021513788383,0.07450838392337392,0.7303377002492228,0.136476280369632,0.8384762187245893,0.07650925055717643,6801]
["High","O14757","Serine/threonine-protein kinase Chk1 [OS=Homo sapiens]",22,9,14,9,476,54.4,8.25,28.33,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CHEK1","ENSG00000149554","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; DNA damage response","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis",600.3,691,614.3,791,950.8,885.6,0.7252797442338432,-0.4633905373096935,0.011402194044320463,1.9430115723776211,0.06551017740842839,1.1836912244514801,1359]
["High","O14763","Tumor necrosis factor receptor superfamily member 10B [OS=Homo sapiens]",11,3,7,3,440,47.8,5.55,2.63,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TNFRSF10B","ENSG00000120889","miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer; miRNA regulation of p53 pathway in prostate cancer; Unfolded protein response; DNA damage response","Cell surface interactions at the vascular wall; Regulation by c-FLIP; RIPK1-mediated regulated necrosis; CASP8 activity is inhibited; TP53 Regulates Transcription of Death Receptors and Ligands; Dimerization of procaspase-8; TRAIL  signaling","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; p53 signaling pathway; Apoptosis; Necroptosis; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Salmonella infection; Influenza A; Lipid and atherosclerosis",41.3,36.9,43.2,45.2,53.9,50.2,0.8131279303415939,-0.2984457438788595,0.04133230766947822,1.3837103464690241,0.13686287459002797,0.863714342569459,2358]
["High","O14772","fucose-1-phosphate guanylyltransferase [OS=Homo sapiens]",7,4,5,3,594,66.6,6.48,10.02,"","","other molecular function","FPGT","ENSG00000254685","","","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",120.2,120.5,125.4,127.6,134.8,121.8,0.9528891202498699,-0.06961974536098152,0.21698750818827156,0.6635652674466772,0.39566521810696503,0.4026721257464614,4282]
["High","O14773","Tripeptidyl-peptidase 1 [OS=Homo sapiens]",20,7,15,7,563,61.2,6.48,42.56,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TPP1","ENSG00000166340","VEGFA-VEGFR2 signaling pathway","XBP1(S) activates chaperone genes","Lysosome",1084.7,1143.9,1061.7,1006.9,1079.6,1056.7,1.0467994400610843,0.06598505779308962,0.20652142239183424,0.6850348924627124,0.3832943346887192,0.41646759982107334,4207]
["High","O14775","Guanine nucleotide-binding protein subunit beta-5 [OS=Homo sapiens]",8,2,2,2,395,43.5,6.46,6.36,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","GNB5","ENSG00000069966","Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells","G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits","Ras signaling pathway; Chemokine signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Relaxin signaling pathway; Morphine addiction; Alcoholism; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",35.5,32.7,35.4,34.8,42,35.7,0.9208888888888889,-0.11890099841784556,0.29149942474773943,0.5353622979517217,0.4779562176460204,0.32061188436194743,4762]
["High","O14776-1","Transcription elongation regulator 1 [OS=Homo sapiens]",26,34,100,34,1098,123.8,8.65,216.66,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","TCERG1","ENSG00000113649; ENSGGOG00000003329; ENSPTRG00000017375","","","Spliceosome",6846.9,6529.4,6764.9,8191.5,7588,7916,0.850001055052647,-0.23446346290963818,0.003972690458559893,2.4009152726935725,0.03834211013650883,1.4163239896472093,809]
["High","O14777","Kinetochore protein NDC80 homolog [OS=Homo sapiens]",36,20,40,20,642,73.9,5.6,78.95,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NDC80","ENSG00000080986","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",2382.9,2360.3,2407.4,2582.1,2464.5,2445.5,0.9544186543158794,-0.06730585379679947,0.06404481862343886,1.1935159999438336,0.17942660344880182,0.7461131639985022,2787]
["High","O14782","Kinesin-like protein KIF3C [OS=Homo sapiens]",6,5,5,2,793,89.4,8.22,13.05,"transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3C","ENSG00000084731","","Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",52.7,67.3,49.1,64.6,71,64.1,0.8467701552328494,-0.23995767303398916,0.16389483969025861,0.7854347201898804,0.3297322618658952,0.48183855827125993,3881]
["High","O14787-2","Isoform 2 of Transportin-2 [OS=Homo sapiens]",34,24,72,12,887,100.3,4.98,136.86,"","","","TNPO2","","","","",1161.9,1177.2,1187.6,1127,1119.9,1157.6,1.0358936701424588,0.05087592442321582,0.041592022094691115,1.3809899648666515,0.13737331155471583,0.8620976324172338,2364]
["High","O14795","Protein unc-13 homolog B [OS=Homo sapiens]",9,12,19,11,1591,180.6,5.99,27.15,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","UNC13B","ENSG00000198722","Synaptic vesicle pathway; 16p11.2 proximal deletion syndrome; Monoamine transport","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle","Synaptic vesicle cycle",586.3,613.1,608.6,613.9,585.2,597,1.0066254662880687,0.009527001678591931,0.7526072715102149,0.12343158994718613,0.8548672644678147,0.0681013130897572,6874]
["Medium","O14798","Tumor necrosis factor receptor superfamily member 10C [OS=Homo sapiens]",4,1,1,1,259,27.4,4.82,2.91,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TNFRSF10C","ENSG00000173535","Apoptosis modulation and signaling; VEGFA-VEGFR2 signaling pathway","TP53 Regulates Transcription of Death Receptors and Ligands","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor",113.9,55.6,68.4,85.1,67.6,81.5,1.015798462852263,0.02261419592391941,0.94998502238237,0.022283241814273845,0.9734229730658196,0.011698408495238937,7620]
["High","O14802","DNA-directed RNA polymerase III subunit RPC1 [OS=Homo sapiens]",28,29,60,28,1390,155.5,8.48,110.91,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3A","ENSG00000148606","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",2034.7,2129,2102,2155.8,2243.5,2177,0.9527697945653331,-0.06980041837882188,0.054799886659699676,1.2612203397477095,0.16170729971237155,0.7912703749405562,2646]
["High","O14818-1","Proteasome subunit alpha type-7 [OS=Homo sapiens]",66,16,112,16,248,27.9,8.46,245.84,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","HEL-S-276; PSMA7","ENSG00000101182","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",4508.7,4875.7,4674,4898.8,5158.8,4812.4,0.9454203093476798,-0.08097223814460931,0.1428921042689351,0.8449917681801269,0.30137805243972043,0.5208883779383768,3702]
["Low","O14827","Ras-specific guanine nucleotide-releasing factor 2 [OS=Homo sapiens]",1,1,1,1,1237,140.7,7.53,0,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","RASGRF2","ENSG00000113319","MAPK signaling pathway; Ras signaling","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor","MAPK signaling pathway; Ras signaling pathway",85.1,101.6,77.2,93.3,103.9,93.2,0.9087465564738291,-0.1380501026694825,0.33237338002781985,0.4783737663860424,0.519866055940949,0.2841085384017746,4992]
["High","O14828","Secretory carrier-associated membrane protein 3 [OS=Homo sapiens]",41,9,31,9,347,38.3,7.64,88.4,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCAMP3","ENSG00000116521; ENSG00000263290","","","",640.2,695.7,677.2,671.9,644.6,688.5,1.0040399002493767,0.005816602703132005,0.9026864661304121,0.04446306881636457,0.9454293665387334,0.02437091194674254,7455]
["High","O14832","Phytanoyl-CoA dioxygenase, peroxisomal [OS=Homo sapiens]",10,4,8,4,338,38.5,8.47,16,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","PHYH","ENSG00000107537","","TYSND1 cleaves peroxisomal proteins; Alpha-oxidation of phytanate","Peroxisome",690,663.9,654,713.8,677.9,671.2,0.9733385040477001,-0.038986467495151056,0.3424227204364266,0.4654374267261938,0.5293281728702472,0.2762749905799079,5051]
["High","O14841","5-oxoprolinase [OS=Homo sapiens]",10,9,11,9,1288,137.4,6.58,25.59,"other metabolic processes","cytosol","other molecular function","OPLAH","ENSG00000178814","Glutathione metabolism","Glutathione synthesis and recycling; Defective OPLAH causes OPLAHD","Glutathione metabolism; Metabolic pathways",140.8,148.5,138.4,134.7,151.1,147.1,0.9879879879879883,-0.01743459333602027,0.7799825462456518,0.10791511545568795,0.8712594736889913,0.05985248654273397,6990]
["High","O14867","Transcription regulator protein BACH1 [OS=Homo sapiens]",29,17,28,17,736,81.9,5.05,55.25,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH1","ENSG00000156273","Integrated cancer pathway; Ferroptosis","Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity","",1164.2,1158.9,1155.5,1001.9,905.7,922.1,1.2293175955048241,0.29785768565958803,1.9180813636629904E-3,2.717132974308007,0.02863552445024977,1.5430948585166457,523]
["Medium","O14874","[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial [OS=Homo sapiens]",4,1,1,1,412,46.3,8.82,2.17,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","BCKDK","ENSG00000103507","Thiamine metabolic pathways","Branched-chain amino acid catabolism","",13.4,18.6,17.1,12.9,15.3,16.6,1.0959821428571428,0.13222429225708887,0.4898901794009535,0.30990126655453726,0.6622338159215105,0.17898864645748452,5776]
["High","O14880","Microsomal glutathione S-transferase 3 [OS=Homo sapiens]",28,3,20,3,152,16.5,9.38,43.62,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","MGST3","ENSG00000143198","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II","Aflatoxin activation and detoxification; Glutathione conjugation","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",516.3,515.2,510.4,440.3,514.9,481.5,1.0732233590867961,0.10195036082170454,0.18061349655588957,0.7432497996441126,0.35132789763537264,0.454287363136944,4014]
["High","O14893","Gem-associated protein 2 [OS=Homo sapiens]",29,7,13,7,280,31.6,5.58,27.35,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","GEMIN2","ENSG00000092208","","snRNP Assembly","",390.3,416.8,373.8,444.1,422.3,454.6,0.8939439818319457,-0.16174366578901986,0.041170667233392626,1.3854120945416828,0.13661732671412222,0.8644942170590688,2353]
["Medium","O14896-1","Interferon regulatory factor 6 [OS=Homo sapiens]",3,1,1,1,467,53.1,5.33,0,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IRF6","ENSCANG00000037044; ENSCATG00000039683; ENSG00000117595; ENSGGOG00000006214; ENSMFAG00000033961; ENSMMUG00000022065; ENSMNEG00000040867; ENSNLEG00000001962; ENSPPAG00000032756; ENSPPYG00000000253; ENSPTRG00000001941","Apoptosis; Primary focal segmental glomerulosclerosis (FSGS); Hypothetical craniofacial development pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway","Interferon gamma signaling; Interferon alpha/beta signaling","",12.8,8.5,11.9,14,8.8,13.1,0.9247910863509751,-0.11280060247612637,0.6862837658855061,0.16349627426936278,0.8071251158358235,0.09305913825764772,6639]
["High","O14907","Tax1-binding protein 3 [OS=Homo sapiens]",26,3,6,3,124,13.7,8.48,13.43,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TAX1BP3","ENSG00000213977","","RHO GTPases Activate Rhotekin and Rhophilins","",296.2,289.3,304.7,190.8,192.8,205.6,1.5108621860149356,0.59537207041642,9.8414861645937675E-5,4.006939313728584,0.00853803599701646,2.068642018509273,90]
["High","O14908-1","PDZ domain-containing protein GIPC1 [OS=Homo sapiens]",32,8,18,8,333,36,6.28,43.29,"cell-cell signaling;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GIPC1","ENSG00000123159","VEGFA-VEGFR2 signaling pathway","","",1201.9,1211.1,1242.9,1317.1,1243,1299,0.9473452359358401,-0.07803781976706226,0.056793337101306116,1.245702611997947,0.16515544733221532,0.782107097374886,2685]
["High","O14910","Protein lin-7 homolog A [OS=Homo sapiens]",15,4,11,2,233,26,8.72,19.9,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","LIN7A","ENSG00000111052","","Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle","",440.7,408.6,460,500.7,440.3,421.6,0.9608836048730369,-0.05756641190349509,0.5626835726757109,0.24973576371650966,0.7169440821559971,0.1445147156824218,6128]
["High","O14920-1","Inhibitor of nuclear factor kappa-B kinase subunit beta [OS=Homo sapiens]",15,6,9,6,756,86.5,5.78,13.02,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","IKBKB","ENSG00000104365","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",166.7,156.5,162.4,170.1,187.2,181.4,0.9014293669946168,-0.14971364358341316,0.03848474517347618,1.4147113847734514,0.1309890541911517,0.8827649936800649,2294]
["High","O14924","Regulator of G-protein signaling 12 [OS=Homo sapiens]",4,5,5,4,1447,156.3,7.44,4.95,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","RGS12","ENSG00000159788","","G alpha (i) signalling events","",14.6,16.1,14,18.9,19.1,15,0.8433962264150943,-0.2457175282672439,0.13364292480421835,0.8740540283015433,0.29017907588190683,0.5373339067040991,3596]
["High","O14929","histone acetyltransferase type B catalytic subunit [OS=Homo sapiens]",35,10,88,10,419,49.5,5.69,190.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","HAT1","ENSG00000128708","Ethanol effects on histone modifications","HATs acetylate histones","Neutrophil extracellular trap formation; Alcoholism",2930.6,3048.9,2992.7,2873.4,3083.5,2958.7,1.0063484229889186,0.009129888731972877,0.8006428455987832,0.09656117277546429,0.8859721284630526,0.0525799402405922,7056]
["Medium","O14933","Ubiquitin/ISG15-conjugating enzyme E2 L6 [OS=Homo sapiens]",5,1,2,1,153,17.8,7.88,4.52,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UBE2L6","ENSG00000156587","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome","Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration",103.9,92.8,106.3,140.9,104.2,100.4,0.8769898697539797,-0.18936791691530763,0.3553192520943875,0.4493812607013804,0.5408055985093524,0.2669588211545613,5130]
["High","O14936","peripheral plasma membrane protein CASK [OS=Homo sapiens]",29,23,54,23,926,105.1,6.43,119,"cell adhesion;protein metabolism;other metabolic processes;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CASK","ENSG00000147044","Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions","",3050.7,3366.9,3265.7,3035,3239,3119,1.030905993825189,0.043912782341734215,0.430367745768737,0.3661602846454689,0.6114103637122086,0.21366720403832754,5496]
["High","O14939-1","Phospholipase D2 [OS=Homo sapiens]",5,5,6,5,933,105.9,7.64,8.76,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","PLD2","ENSG00000129219","Ras signaling; EGF/EGFR signaling pathway","Role of phospholipids in phagocytosis; RAC1 GTPase cycle; RAC2 GTPase cycle; Synthesis of PG; Synthesis of PA","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways; Ras signaling pathway; cAMP signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Endocytosis; Fc gamma R-mediated phagocytosis; Glutamatergic synapse; GnRH signaling pathway; Parathyroid hormone synthesis, secretion and action; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Choline metabolism in cancer",340.9,351.1,367.2,312.2,324.9,313.7,1.114009255363904,0.15576121886478297,0.013898718746072097,1.8570252333543804,0.07201141072948303,1.1425986810103768,1507]
["High","O14949","Cytochrome b-c1 complex subunit 8 [OS=Homo sapiens]",29,3,6,3,82,9.9,10.08,11.63,"other metabolic processes;transport;developmental processes","other membranes;mitochondrion","","UQCRQ","ENSG00000164405","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly","Respiratory electron transport","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",569.9,552.5,655.6,497.1,553.4,533.5,1.1224747474747474,0.16668298875016024,0.1458124508058841,0.8362053903841554,0.3055565260043862,0.5149084362857438,3726]
["High","O14950","Myosin regulatory light chain 12B [OS=Homo sapiens]",40,6,23,6,172,19.8,4.84,56.04,"other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL12B","ENSG00000118680","Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion","RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Salmonella infection",554.2,544.4,581.1,599.7,449.7,473.8,1.1027442226890756,0.14109820212620514,0.3362982839229596,0.47327534881587496,0.5227587101075987,0.28169872231678894,5023]
["High","O14964","Hepatocyte growth factor-regulated tyrosine kinase substrate [OS=Homo sapiens]",24,16,34,16,777,86.1,6.16,73.13,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","HGS","ENSG00000185359","TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway","Lysosome Vesicle Biogenesis; Ub-specific processing proteases; Cargo recognition for clathrin-mediated endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle","Endocytosis; Phagosome",1648.5,1575.3,1604,1599.1,1499.7,1559.4,1.0364089133141554,0.05159332813627402,0.19031297883295908,0.7205315929881786,0.3630500216779244,0.4400335329748128,4093]
["High","O14965","Aurora kinase A [OS=Homo sapiens]",16,5,11,5,403,45.8,9.39,24.71,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AURKA","ENSG00000087586","Gastric cancer network 1; EGF/EGFR signaling pathway","Regulation of TP53 Activity through Phosphorylation; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA","Oocyte meiosis; Progesterone-mediated oocyte maturation",235.1,247.5,266.4,250.8,257.3,258.9,0.9765319426336375,-0.03426085904418241,0.5592390302132072,0.25240252607728153,0.7145374485198366,0.14597500513847275,6111]
["High","O14966-1","Ras-related protein Rab-7L1 [OS=Homo sapiens]",23,4,5,4,203,23.1,7.18,10.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB29; RAB7L1","ENSG00000117280; ENSNLEG00000029152; ENSPPAG00000013675; ENSPPYG00000000298; ENSPTRG00000001905","","RAB geranylgeranylation","",408.1,403.7,435.6,455.2,493.6,480.5,0.8727349051983488,-0.1963845957118121,0.01576497931012824,1.8023065948813815,0.07751445746440888,1.1106172883138234,1588]
["High","O14967","calmegin [OS=Homo sapiens]",28,13,34,12,610,70,4.69,44.08,"cell organization and biogenesis;stress response;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","CLGN","ENSG00000153132","","","",1181.8,1316.4,1205.1,1226.7,1270.6,1217.4,0.9969311115298677,-0.00443427781447817,0.9362720796131376,0.028597927432845043,0.966730018198807,0.014694795800726457,7562]
["High","O14972","Down syndrome critical region protein 3 [OS=Homo sapiens]",8,2,3,2,297,33,7.68,5.94,"transport","other cytoplasmic organelle","","VPS26C","ENSG00000157538","","","",75.5,87.4,80.7,76.3,77.2,79.5,1.0454935622317596,0.06418417836468975,0.3787741219387272,0.4216196998987576,0.5620426347581874,0.25023073898980636,5262]
["High","O14974","Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",49,45,141,44,1030,115.2,5.4,267.69,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12A","ENSG00000058272","Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton","Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","cGMP-PKG signaling pathway; cAMP signaling pathway; Vascular smooth muscle contraction; Focal adhesion; Platelet activation; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer",6854.1,6829.6,7120.8,6996.8,6526,6694.9,1.0290240729657676,0.041276733001651536,0.304760553444363,0.5160412464206741,0.491646777126774,0.30834680340645115,4840]
["Medium","O14975","very long-chain acyl-CoA synthetase [OS=Homo sapiens]",2,1,1,1,620,70.3,8.51,0,"other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC27A2","ENSG00000140284","PPAR signaling pathway","Peroxisomal protein import; Neutrophil degranulation; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Alpha-oxidation of phytanate; Synthesis of bile acids and bile salts via 24-hydroxycholesterol","PPAR signaling pathway; Peroxisome; Insulin resistance",32.4,26.2,35.2,19.3,27.1,21,1.3916913946587535,0.4768393313335178,0.06884363213900954,1.1621362246850218,0.18801366902461927,0.7258105753843753,2859]
["High","O14976","Cyclin-G-associated kinase [OS=Homo sapiens]",20,15,36,15,1311,143.1,5.73,66.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","GAK","ENSG00000178950","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","",1040.6,1014,1022.2,1031.2,1100.1,1056.3,0.9652403061864725,-0.05103993449197658,0.16267607801615533,0.7886763066170579,0.3281257600491193,0.4839596732773776,3871]
["High","O14979-1","Heterogeneous nuclear ribonucleoprotein D-like [OS=Homo sapiens]",29,14,153,12,420,46.4,9.57,280.03,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPDL; HNRPDL","ENSG00000152795; ENSPPAG00000043177; ENSPTRG00000016217","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",4577.3,4353.9,4599.5,5138.9,5004.2,5184.7,0.8827555161210351,-0.17991416382959155,3.2740888782344353E-3,2.4849095354302277,0.035163804623458694,1.45390414163063,727]
["High","O14980","Exportin-1 [OS=Homo sapiens]",44,39,187,39,1071,123.3,6.06,400.66,"transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPO1","ENSG00000082898","eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MAPK6/MAPK4 signaling; Deactivation of the beta-catenin transactivating complex; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Heme signaling; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Influenza A; Human T-cell leukemia virus 1 infection",7595.1,8274.5,7828.4,8362.6,9213.2,8926.3,0.8941932903430293,-0.1613413743536595,0.04304594746180715,1.3660677287125136,0.14021808835285365,0.8531959580875321,2397]
["High","O14981","TATA-binding protein-associated factor 172 [OS=Homo sapiens]",10,13,29,13,1849,206.8,6.52,67.1,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BTAF1","ENSG00000095564","","","",911.3,922.6,871.8,869.1,845.2,868.7,1.0475029036004646,0.06695424297396838,0.07740333484940991,1.1112403277473815,0.20348997929434093,0.6914569724059584,2970]
["High","O14994","Synapsin-3 [OS=Homo sapiens]",5,2,2,2,580,63.3,9.39,2.45,"cell-cell signaling;transport;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","SYN3","ENSG00000185666","Synaptic vesicle pathway","Serotonin Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle","",95,88.3,88,132.8,147.2,123.7,0.6720336883824622,-0.5733945391986438,0.003612720008256079,2.442165695664554,0.036729320083936805,1.4349871110374306,768]
["High","O15013","rho guanine nucleotide exchange factor 10 [OS=Homo sapiens]",12,11,18,11,1369,151.5,5.68,26.01,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity","ARHGEF10","ENSG00000104728; ENSG00000274726","","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events","",661.7,666.8,654.8,626.4,654.6,680.4,1.0111654940348729,0.016019137581216432,0.6714418211883592,0.17299161193268736,0.7967504163888615,0.09867770088800742,6580]
["High","O15014","zinc finger protein 609 [OS=Homo sapiens]",10,15,23,14,1411,151.1,8.03,37.1,"developmental processes;other biological processes","nucleus","other molecular function","ZNF609","ENSG00000180357","","","",1092.5,1106.7,1134.8,1305.5,1080.6,1149.2,0.9430599949084942,-0.08457854073807361,0.37771493805013956,0.42283583914796163,0.5610040396225013,0.25103401150775145,5257]
["High","O15015","Zinc finger protein 646 [OS=Homo sapiens]",6,10,10,9,1829,200.6,7.33,23.91,"","","","","","","","",472.5,524.1,522.9,517.1,493.9,510.6,0.9986198738170348,-1.9924764509066527E-3,0.9714042919880067,0.012599982000938318,0.9847733980579534,0.006663691629015181,7702]
["High","O15020","Spectrin beta chain, non-erythrocytic 2 [OS=Homo sapiens]",26,51,98,39,2390,271.2,6.11,197.61,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTBN2","ENSG00000173898","","MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","Spinocerebellar ataxia; Pathways of neurodegeneration",1940,1874.4,1906,1769.7,1840,1770.8,1.063172567605241,0.08837578522478823,0.01947193529132047,1.7105908823488678,0.08717710479049899,1.0595975582867807,1744]
["High","O15027-5","Isoform 5 of Protein transport protein Sec16A [OS=Homo sapiens]",16,27,61,27,2201,235.6,5.67,122.53,"","","","","","","","",2664,2459.7,2502.3,2402.1,2268.4,2306.2,1.0930669227571774,0.12838173236777153,0.04280408394411915,1.3685147929078258,0.13989714836152461,0.8541911379990683,2389]
["High","O15031","Plexin-B2 [OS=Homo sapiens]",15,19,27,19,1838,205,6.24,58.63,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PLXNB2","ENSG00000196576","","","Axon guidance",785.3,905,873.6,884.6,871.9,852.3,0.9827890217724624,-0.02504635269693686,0.7068584162911138,0.15066756665742856,0.8225261571387505,0.08485028216778527,6710]
["High","O15037","protein KHNYN [OS=Homo sapiens]",8,3,4,3,678,74.5,7.02,11.83,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHNYN","ENSG00000100441","","","",176.6,158.1,176.9,161.1,161.8,161.5,1.0561519405450042,0.07881739918730829,0.21870756282338127,0.6601361989666007,0.39722462212722986,0.40096383942497216,4299]
["Medium","O15040","Tectonin beta-propeller repeat-containing protein 2 [OS=Homo sapiens]",1,1,1,1,1411,153.8,5.55,2.2,"other metabolic processes;transport","other cell component","","TECPR2","ENSG00000196663","","","",20.5,21,12.9,23.7,18.5,17.7,0.9081803005008346,-0.1389493515384464,0.600190409433162,0.2217109485371802,0.7457490001359212,0.12740732024648058,6284]
["High","O15042","U2 snRNP-associated SURP motif-containing protein [OS=Homo sapiens]",34,28,87,28,1029,118.2,8.47,154.17,"RNA metabolism OR transcription;other metabolic processes","nucleus","","U2SURP","ENSG00000163714","","mRNA Splicing - Major Pathway","Spliceosome",3818.7,3853.8,3819.6,4470.7,4276.8,4403.2,0.8738774361821045,-0.1944971430923834,6.7593630507364769E-4,3.1700942266298737,0.018389235784024537,1.7354363187052306,287]
["High","O15047","Histone-lysine N-methyltransferase SETD1A [OS=Homo sapiens]",11,13,20,12,1707,185.9,5.14,42.36,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETD1A","ENSG00000099381","Histone modifications","PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Lysine degradation; Metabolic pathways",618.6,625,637,645.2,598,633.4,1.0021315144410103,3.0718526263169323E-3,0.9341976965978507,0.02956120786398893,0.9656096922208125,0.01519838369685979,7554]
["Low","O15050","TPR and ankyrin repeat-containing protein 1 [OS=Homo sapiens]",0,1,1,1,2925,336,6.76,0,"","","","TRANK1","ENSG00000168016","","","",50.3,47.1,46.9,55.3,47.1,43.3,0.9903912148249829,-0.01392957757331432,0.9059259543475546,0.042907297833593074,0.9472974221970948,0.02351364450321332,7467]
["High","O15054","Lysine-specific demethylase 6B [OS=Homo sapiens]",2,2,2,2,1643,176.5,8.54,2.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6B","ENSG00000132510","Pathways affected in adenoid cystic carcinoma; Vitamin D-sensitive calcium signaling in depression","Oxidative Stress Induced Senescence; HDMs demethylate histones","",57.6,47.1,45.9,58.3,61.6,53,0.8710237131289762,-0.19921609897035375,0.17252624133833508,0.7631448391316455,0.3412069129609221,0.46698217847060924,3948]
["High","O15056","Synaptojanin-2 [OS=Homo sapiens]",3,5,5,5,1496,165.4,7.34,10.21,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ2","ENSG00000078269","","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",206.3,191.2,186.9,213.9,228,238.3,0.8591590708615112,-0.21900282790434378,0.02554940533580749,1.592619203646015,0.1023549291236454,0.9898912381050009,1949]
["High","O15061-1","Synemin [OS=Homo sapiens]",3,3,3,3,1565,172.7,5.16,2.25,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SYNM","ENSG00000182253","","","",26.9,22.3,20.2,24.1,26.1,20.7,0.9788434414668548,-0.030849964661255162,0.8529497464402921,0.06907655556940048,0.9167008424233724,0.03777236954480545,7265]
["High","O15063","Uncharacterized protein KIAA0355 [OS=Homo sapiens]",4,3,3,3,1070,115.9,7.15,9.75,"signal transduction","cytosol;other cell component","other molecular function","GARRE1","ENSG00000166398","","RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",115.5,139.9,107.8,110.1,116.5,106,1.0920024052916415,0.1269760340036458,0.3716378390425228,0.429880073874451,0.5555711750419333,0.2552602950528093,5223]
["High","O15066","Kinesin-like protein KIF3B [OS=Homo sapiens]",12,9,10,6,747,85.1,7.69,24.97,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3B","ENSG00000101350","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",544.2,531.8,553.9,577.9,605.5,615.9,0.9058522758850663,-0.14265229651949035,0.012274523054823726,1.9109953740467405,0.0674925887408899,1.1707439137711615,1420]
["High","O15067","Phosphoribosylformylglycinamidine synthase [OS=Homo sapiens]",35,36,100,36,1338,144.6,5.76,222.91,"other metabolic processes;other biological processes","cytosol","other molecular function","PFAS","ENSG00000178921","","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Metabolic pathways",4445.9,4353.1,4407.8,4922.7,4720.6,4724.6,0.9191879119425942,-0.12156826937411915,0.005769176620238229,2.2388861651464342,0.046486822549865935,1.332670137538564,969]
["High","O15068","Guanine nucleotide exchange factor DBS [OS=Homo sapiens]",4,3,3,3,1137,128,6.43,6.81,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","MCF2L","ENSG00000126217","","CDC42 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RHOB GTPase cycle","",79.7,68.5,65.6,81,80.3,75.6,{"$f":"AVERAGE(T258:V258)/AVERAGE(W258:Y258)","v":0.9024905023216546},{"$f":"LOG(Z258,2)","v":-0.1480163455197408},{"$f":"TTEST(T258:V258,W258:Y258,2,2)","v":0.17099611895503206},{"$f":"-LOG10(AB258)","v":0.7670137465408361},{"$f":"AB258*7808/AF258","v":0.33929801697608397},{"$f":"-LOG10(AD258)","v":0.469418678577284},3935]
["High","O15069","NAC-alpha domain-containing protein 1 [OS=Homo sapiens]",1,1,2,1,1562,161,4.23,4.2,"transport","translational apparatus;nucleus;other cell component","other molecular function","NACAD","ENSG00000136274","","","",36.7,35,28.6,34.2,30.8,30.1,1.0546792849631967,0.07680435975161738,0.5656885022008538,0.2474226483436803,0.7188958048802516,0.1433340507085005,6144]
["High","O15075-1","serine/threonine-protein kinase DCLK1 [OS=Homo sapiens]",11,4,8,4,740,82.2,8.66,21.01,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","DCLK1; LOC111158544","ENSCANG00000018654; ENSCCAG00000004898; ENSCJAG00000018203; ENSG00000133083; ENSMFAG00000030114; ENSMLEG00000042752; ENSMMUG00000016791; ENSMNEG00000028724; ENSNLEG00000001363; ENSPPAG00000038110; ENSPTRG00000005778; ENSRBIG00000027120; ENSRROG00000019788; ENSSBOG00000035278","Orexin receptor pathway","","",244.6,236.8,239.8,267.3,275.7,291.5,0.8642300778909526,-0.21051265281761952,0.007129541240900082,2.1469384144616743,0.051071062393530126,1.2918251077436627,1090]
["High","O15078-1","Centrosomal protein of 290 kDa [OS=Homo sapiens]",3,6,7,6,2479,290.2,5.95,16.08,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CEP290","ENSG00000198707","Clear cell renal cell carcinoma pathways; Ciliary landscape; Joubert syndrome; Ciliopathies","Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",615.2,570.2,611.3,696.3,621.4,604,0.9349534266534839,-0.0970335938545137,0.259826103277606,0.585317219929862,0.44314596207766443,0.35345320360975063,4578]
["High","O15083","ERC protein 2 [OS=Homo sapiens]",6,7,14,1,957,110.5,6.99,27.61,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","ERC2","ENSG00000187672","Exercise-induced circadian regulation","","",1063.6,717.4,601,66.6,48.7,79.4,12.234206471494609,3.612848624031182,0.006351445232593648,2.1971274424048173,0.04876311148091564,1.3119085906689265,1017]
["High","O15084","serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A [OS=Homo sapiens]",12,9,11,9,1053,112.9,6.25,28.1,"","cytosol;nucleus","","ANKRD28","ENSG00000206560","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",320.2,334,346.7,318.3,346.7,327.2,1.0087683934690588,0.01259497925241829,0.8109798616180421,0.09098993012515562,0.8912217817753234,0.05001420773000879,7105]
["High","O15085-2","Isoform 2 of Rho guanine nucleotide exchange factor 11 [OS=Homo sapiens]",15,16,21,16,1562,172.1,5.54,39.81,"","","","ARHGEF11","","","","",485.1,534.9,518.8,554.2,551.1,549.1,0.9301257253384911,-0.10450235601831995,0.05923603117016734,1.227414047021809,0.16973025004648315,0.7702407489758348,2725]
["High","O15091","Mitochondrial ribonuclease P protein 3 [OS=Homo sapiens]",16,8,10,8,583,67.3,8.78,22.84,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","other molecular function","PRORP","ENSG00000100890","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",384.7,325.8,378.6,445.8,391.2,415,0.8698881789137379,-0.20109813541447177,0.09083787525446238,1.0417330327091754,0.22494834442969944,0.6479171987984446,3153]
["High","O15111","Inhibitor of nuclear factor kappa-B kinase subunit alpha [OS=Homo sapiens]",4,2,2,2,745,84.6,6.73,8.32,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CHUK","ENSG00000213341","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Constitutive Signaling by AKT1 E17K in Cancer; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; AKT phosphorylates targets in the cytosol","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",60.6,62.1,67.9,64.6,58,53.9,1.079886685552408,0.11087993575139946,0.2870500415410301,0.5420423859465489,0.473444597455083,0.3247308348809774,4734]
["High","O15116","U6 snRNA-associated Sm-like protein LSm1 [OS=Homo sapiens]",29,4,6,4,133,15.2,5.22,5.98,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM1","ENSG00000175324","","mRNA decay by 5' to 3' exoribonuclease","RNA degradation",430.6,366.5,429.7,369.8,338.9,323.4,1.1886445111907762,0.24931731169793533,0.06178147733843487,1.209141710921926,0.17496908779778725,0.7570386723690643,2757]
["High","O15118","Niemann-Pick C1 protein [OS=Homo sapiens]",5,7,10,7,1278,142.1,5.36,21.92,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","NPC1","ENSG00000141458","Irinotecan pathway; Irinotecan pathway; Irinotecan pathway; Ebola virus infection in host; Irinotecan pathway; Irinotecan pathway","LDL clearance","Lysosome; Cholesterol metabolism",494.8,522.7,524.2,456,446.7,449.4,1.1402263146216995,0.1893202020897962,3.1488844716710688E-3,2.5018432727506084,0.034290780969048404,1.4648226237597732,717]
["High","O15120","1-acyl-sn-glycerol-3-phosphate acyltransferase beta [OS=Homo sapiens]",6,1,2,1,278,30.9,9.01,4.84,"other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","AGPAT2","ENSG00000169692","Adipogenesis; Triacylglyceride synthesis; Ciliary landscape; Congenital generalized lipodystrophy (CGL)","Neutrophil degranulation; Synthesis of PA","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fat digestion and absorption",13.6,14.7,18.8,18.7,16.6,18.2,0.8803738317757008,-0.1838118316757263,0.2788556053386643,0.5546206212345178,0.46325629074133856,0.3341786745115999,4700]
["High","O15121","Sphingolipid delta(4)-desaturase DES1 [OS=Homo sapiens]",6,3,5,3,323,37.8,7.46,14.01,"cell organization and biogenesis;other metabolic processes;developmental processes","plasma membrane;other membranes;mitochondrion;ER/Golgi","other molecular function","DEGS1","ENSG00000143753","Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence","Neutrophil degranulation; Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",113.9,105.8,112,118.4,103.4,121.9,0.9650858306662786,-0.05127083958427518,0.55265828265379,0.25754331684946136,0.7092629636687693,0.14919271757178676,6084]
["High","O15126-1","Secretory carrier-associated membrane protein 1 [OS=Homo sapiens]",6,2,5,2,338,37.9,7.42,13.7,"transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP1","ENSG00000085365","","Neutrophil degranulation","",298.4,285.5,324.4,318.7,286.6,308.3,0.9941987740805605,-0.008393770553719652,0.9109883059048199,0.04048719790472315,0.9509353866985072,0.02184899111054913,7480]
["High","O15127","Secretory carrier-associated membrane protein 2 [OS=Homo sapiens]",17,4,13,4,329,36.6,6.1,33.7,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP2","ENSG00000140497","Serotonin transporter activity; Monoamine transport","","",564.3,562.8,555.1,602.3,551.6,594.7,0.9620267642685575,-0.05585106353196209,0.23977511050983283,0.6201959001747955,0.42175356225743965,0.37494124054152683,4439]
["High","O15143","Actin-related protein 2/3 complex subunit 1B [OS=Homo sapiens]",30,9,23,9,372,40.9,8.35,62.02,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ARPC1B","ENSG00000130429","Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",1462.1,1675,1576.3,1462.1,1745.6,1690.8,0.9622129223231601,-0.055571920237178114,0.5930958159481872,0.226875139728297,0.7397591263455984,0.13090966828009123,6260]
["High","O15144","Actin-related protein 2/3 complex subunit 2 [OS=Homo sapiens]",59,17,56,17,300,34.3,7.36,116.07,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","ARPC2","ENSG00000163466","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",2662.4,3205.6,2786.4,2739,3446.9,3096,0.9323953069953349,-0.10098635188733161,0.46976518018444463,0.3281191770309103,0.6457617124788986,0.18992770808329376,5680]
["High","O15145","Actin-related protein 2/3 complex subunit 3 [OS=Homo sapiens]",21,4,14,4,178,20.5,8.59,26.18,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC3","ENSG00000111229","Pathogenic Escherichia coli infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",568.9,540.1,619.9,472.6,494.8,488.7,1.1873497699333837,0.2477449872264472,0.019958072550671984,1.6998814029798353,0.08779303125388555,1.0565399557123127,1775]
["High","O15151","Protein Mdm4 [OS=Homo sapiens]",5,2,2,2,490,54.8,5,2.63,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","nucleus","other molecular function","MDM4","ENSG00000198625","Glioblastoma signaling pathways; Malignant pleural mesothelioma","Regulation of TP53 Activity through Methylation; Ub-specific processing proteases; Regulation of TP53 Degradation; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Oncogene Induced Senescence; Stabilization of p53","p53 signaling pathway; MicroRNAs in cancer",44.2,38.8,35.9,55.8,52,55.4,0.7285539215686274,-0.4568923422258399,0.005542328330094279,2.256307749985671,0.04526621297215077,1.3442258376031357,956]
["High","O15155","BET1 homolog [OS=Homo sapiens]",25,2,3,2,118,13.3,9.06,9.82,"cell organization and biogenesis;transport","other membranes;ER/Golgi","other molecular function","BET1","ENSG00000105829","","COPI-mediated anterograde transport; COPII-mediated vesicle transport","SNARE interactions in vesicular transport",129.5,142.8,142.5,161,174.2,184,0.7989214175654853,-0.32387448918591294,0.012035884045887353,1.919522004919482,0.06703008746810873,1.1737302138914867,1402]
["Medium","O15156","Zinc finger and BTB domain-containing protein 7B [OS=Homo sapiens]",1,1,1,1,539,58,5.86,2.12,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB7B","ENSG00000160685","Ectoderm differentiation; Ectoderm differentiation","","",52.4,54.3,54.7,91.2,72.1,89.8,0.6376926116159619,-0.6490669288329042,0.007816149516225574,2.1070071415294764,0.053440013504981856,1.2721334407806701,1142]
["High","O15160","DNA-directed RNA polymerases I and III subunit RPAC1 [OS=Homo sapiens]",34,9,31,9,346,39.2,5.5,53.07,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR1C","ENSG00000171453","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase; Cytosolic DNA-sensing pathway",947.3,904,871.1,833.5,853.4,833.6,1.0801031541360842,0.11116910206828204,0.04317788177993052,1.3647386670933177,0.14053059647257085,0.8522291104025129,2399]
["High","O15162","phospholipid scramblase 1 [OS=Homo sapiens]",9,2,2,2,318,35,4.94,2.44,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;transporter activity;nucleic acid binding activity;other molecular function","PLSCR1","ENSG00000188313","EGF/EGFR signaling pathway; Complement system in neuronal development and plasticity","","",59.5,58,65.3,71.9,64,65.9,0.9058473736372646,-0.14266010404828752,0.1239164162536775,0.9068711551565188,0.27636086207046956,0.5585234612629161,3501]
["High","O15164","Transcription intermediary factor 1-alpha [OS=Homo sapiens]",29,19,35,18,1050,116.8,7.11,75.15,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function","TRIM24","ENSG00000122779","","Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",759.4,781.1,758.5,956.8,880.8,847.9,0.8560789424688141,-0.22418425543735376,0.01762614718554303,1.7538426076620859,0.08275703982244137,1.0821950522229695,1663]
["Medium","O15169","Axin-1 [OS=Homo sapiens]",1,1,1,1,862,95.6,6.96,1.89,"cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","AXIN1","ENSG00000103126","Alzheimer's disease and miRNA effects; Neural crest differentiation; Mesodermal commitment pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Wnt signaling pathway; TGF-beta signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)","Ub-specific processing proteases; Degradation of AXIN; Estrogen-dependent gene expression; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling","Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Colorectal cancer; Endometrial cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",43.7,39.9,47.9,54.6,42.4,49.6,0.8969986357435198,-0.15682230395414717,0.2996753114012255,0.5233490347115787,0.4861551696282503,0.3132250917303018,4813]
["High","O15173","Membrane-associated progesterone receptor component 2 [OS=Homo sapiens]",52,12,38,10,223,23.8,4.88,90.01,"transport;developmental processes;signal transduction","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","PGRMC2","ENSG00000164040","Ciliary landscape","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","",721.5,670.4,662.3,687.5,654,686.9,1.0127193847367382,0.01823447193513724,0.7106696733576481,0.14833221695442456,0.8248712367439448,0.08361383997859131,6727]
["High","O15182","Centrin-3 [OS=Homo sapiens]",34,5,6,5,167,19.5,4.74,10.29,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","CETN3","ENSG00000153140","Breast cancer pathway","","",347.9,303.5,367.4,402.5,312.1,315.7,0.9888382024653013,-0.016193613940192243,0.9182537052538862,0.03703731055351511,0.9549447163855012,0.020021769844188447,7508]
["High","O15194-1","CTD small phosphatase-like protein [OS=Homo sapiens]",11,3,4,2,276,31.1,5.54,2.79,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","CTDSPL","ENSG00000144677; ENSPTRG00000014749","","","",110.7,107.2,103.4,137.4,143.6,135.2,0.7719846227775109,-0.37335598426392247,6.4758012030515779E-4,3.188706491874022,0.01812295906574434,1.7417708904889846,279]
["High","O15213","WD repeat-containing protein 46 [OS=Homo sapiens]",26,15,25,15,610,68,9.67,52.8,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","WDR46","ENSG00000204221; ENSG00000206284; ENSG00000226916; ENSG00000227057; ENSG00000236222","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",629,601.1,618.2,645.1,621.8,692.8,0.9431545644741542,-0.08443387528330616,0.17298877685884806,0.7619820720525956,0.3417753971948091,0.4662592033095507,3952]
["High","O15226","NF-kappa-B-repressing factor [OS=Homo sapiens]",36,22,44,22,690,77.6,8.79,73.45,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","NKRF","ENSG00000186416","Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway","","",2579.7,2413.4,2442.4,2342.8,2220.8,2300.2,1.0832920539642763,0.11542224387316047,0.03809411589277028,1.4191421012968197,0.13017017807035025,0.8854885010440533,2285]
["High","O15228","Dihydroxyacetone phosphate acyltransferase [OS=Homo sapiens]",26,16,30,16,680,77.1,6.57,55.14,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","other molecular function","GNPAT","ENSG00000116906","Triacylglyceride synthesis","Peroxisomal protein import; Plasmalogen biosynthesis; Synthesis of PA","Glycerophospholipid metabolism; Peroxisome",1143.4,1122.5,1129.8,1077.8,1096.5,1070,1.046666461178066,0.06580177515617845,7.161442129136655E-3,2.1449995132143758,0.05120562284276465,1.290682346924459,1092]
["High","O15230","Laminin subunit alpha-5 [OS=Homo sapiens]",11,31,40,31,3695,399.5,7.02,79.53,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;extracellular structural activity","LAMA5","ENSG00000130702","Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Malignant pleural mesothelioma","Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer",1733.2,1564,1636.8,1653.2,1575.2,1604.1,1.0210036213140197,0.029987983201525,0.5651641956181996,0.24782535945261097,0.7183464169602641,0.1436660701135389,6143]
["High","O15231-1","zinc finger protein 185 [OS=Homo sapiens]",4,3,4,2,689,73.5,7.01,8.4,"","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ZNF185","ENSG00000147394","","","",183.7,197.9,189.6,192.8,174.3,170.4,1.0626976744186047,0.08773122466491484,0.2350506894215548,0.6288384706551039,0.4154087331379583,0.3815243775318846,4418]
["High","O15231-2","Isoform 2 of Zinc finger protein 185 [OS=Homo sapiens]",4,2,3,1,452,48.6,5.43,4.51,"","","","ZNF185","","","","",90.9,91.9,85.8,103.1,96.4,78.2,0.9672308246308968,-0.04806787239140337,0.7128568537894273,0.14699767049983975,0.8261817299076515,0.08292441319388272,6737]
["High","O15234","Protein CASC3 [OS=Homo sapiens]",10,6,6,6,703,76.2,6.48,15.76,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CASC3","ENSG00000108349","","Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Nucleocytoplasmic transport; mRNA surveillance pathway",352.5,403.2,384.2,497.8,446.1,499.7,0.7896231643114436,-0.340763781705195,0.011602145154403833,1.9354617053774494,0.06588330862951645,1.1812245988850953,1375]
["High","O15235","28S ribosomal protein S12, mitochondrial [OS=Homo sapiens]",24,2,3,2,138,15.2,10.29,10.61,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS12","ENSG00000128626; ENSG00000283018","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",52.6,60.7,52.6,56.7,64.5,60.5,0.9130434782608697,-0.1312445332782523,0.2084961347601104,0.6809019918552844,0.38540194607171924,0.41408609672240493,4224]
["High","O15240","Neurosecretory protein VGF [OS=Homo sapiens]",29,17,38,17,615,67.2,4.78,79.58,"cell-cell signaling;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;ER/Golgi;other cell component","signal transduction activity or receptor binding","VGF","ENSG00000128564","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; NGF-stimulated transcription","",898.5,684.8,878.7,375.9,351.2,302,2.3923816927412305,1.2584475828029642,2.6174425691027317E-3,2.5821228386636017,0.03124922259870662,1.5051607823292334,654]
["High","O15243","Leptin receptor gene-related protein [OS=Homo sapiens]",18,3,4,3,131,14.2,6.51,5.11,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding","LEPROT","ENSG00000213625","","","",294.1,274,263.3,345.3,314.5,301,0.8653205661948379,-0.20869340308126128,0.053546684733044796,1.2712674127259709,0.15951641144433948,0.7971946290139359,2621]
["High","O15254","Peroxisomal acyl-coenzyme A oxidase 3 [OS=Homo sapiens]",13,5,7,5,700,77.6,7.25,11.54,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOX3","ENSG00000087008","PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","Fatty acid degradation; beta-Alanine metabolism; alpha-Linolenic acid metabolism; Propanoate metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; PPAR signaling pathway; cAMP signaling pathway; Peroxisome; Alcoholic liver disease",57.5,49.9,48.4,49.8,44.2,51.7,1.0693205216197668,0.09669435599715677,0.4033323335213227,0.39433696096530496,0.585356665452507,0.23257943197305872,5380]
["High","O15258","Protein RER1 [OS=Homo sapiens]",14,2,5,2,196,22.9,9.54,7.25,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","RER1","ENSG00000157916","","","",240.4,230.2,254.5,200.9,184.4,208.1,1.2219413549039435,0.289175047006472,0.011549499743792987,1.937436826439833,0.06591995175404652,1.1809831191652949,1368]
["High","O15260-1","surfeit locus protein 4 [OS=Homo sapiens]",17,4,16,4,269,30.4,7.78,29.12,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","SURF4","ENSG00000148248; ENSG00000280951; ENSGGOG00000014456; ENSNLEG00000013096; ENSPTRG00000021519","","COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation","",389.5,421,438.3,398.8,443.6,425.3,0.9850911098840419,-0.021670931029863255,0.7606788660093419,0.11879864960934773,0.8600319411817174,0.06548541896414782,6906]
["Medium","O15265","Ataxin-7 [OS=Homo sapiens]",2,1,1,1,892,95.4,9.85,2.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","","ATXN7","ENSG00000163635","","Ub-specific processing proteases; HATs acetylate histones","",17.5,19.9,17.7,18.6,16.3,22.1,0.9666666666666663,-0.0489096004809469,0.7497410957781481,0.12508868339088164,0.8526039143366997,0.06925267782197757,6866]
["High","O15269","serine palmitoyltransferase 1 [OS=Homo sapiens]",31,14,50,14,473,52.7,6.01,111.29,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC1","ENSG00000090054","Sphingolipid pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",1718,1745,1766.5,1506.4,1535.7,1534.4,1.1426854583196766,0.192428334284992,2.1329219960812077E-4,3.6710250270123383,0.011811244642129126,1.927704335009083,141]
["High","O15270","Serine palmitoyltransferase 2 [OS=Homo sapiens]",18,8,17,8,562,62.9,7.78,38.64,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC2","ENSG00000100596","Sphingolipid pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",612.3,586.3,555.7,434.3,453.8,448.8,1.3122148253422095,0.3920039258135067,1.3178724332406672E-3,2.8801266263284515,0.024154807414889973,1.6169964207725351,426]
["High","O15287","Fanconi anemia group G protein [OS=Homo sapiens]",12,5,6,5,622,68.5,5.47,11.98,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus","nucleic acid binding activity","FANCG","ENSG00000221829","Retinoblastoma gene in cancer; DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",46.6,52.7,46.4,53.1,70.4,47.8,0.8505545826036194,-0.2335242740194864,0.2974623192614148,0.5265680402657792,0.48467983906367423,0.31454504498839875,4792]
["High","O15294","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit [OS=Homo sapiens]",11,12,27,12,1046,116.9,6.7,58.4,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","OGT","ENSG00000147162","Ectoderm differentiation; Ectoderm differentiation; Malignant pleural mesothelioma","UCH proteinases; Regulation of necroptotic cell death; HATs acetylate histones","Other types of O-glycan biosynthesis; Insulin resistance",1025.1,1068.5,1015.6,1320.7,1282.9,1316.9,0.793062109424818,-0.33449423847849147,0.000181315891719106,3.7415641298071263,0.010974530872424648,1.95961403544774,129]
["High","O15305","Phosphomannomutase 2 [OS=Homo sapiens]",38,10,42,10,246,28.1,6.77,55.91,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PMM2","ENSG00000140650","Nephrotic syndrome","Defective PMM2 causes PMM2-CDG (CDG-1a); Synthesis of GDP-mannose","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",2118.2,2070.3,2080.5,2329.4,2112,2210.9,0.9423808306901373,-0.0856179018029755,0.11872077371903272,0.9254732817010699,0.26876538161734054,0.5706266714098251,3449]
["High","O15318","DNA-directed RNA polymerase III subunit RPC7 [OS=Homo sapiens]",14,3,3,3,223,25.9,4.63,5.5,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","POLR3G","ENSG00000113356","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",55.4,50.1,56.9,114,91.9,87.7,0.553133514986376,-0.8543003356580368,0.006526526423116365,2.1853178993752818,0.0491883381386994,1.3081378501258607,1036]
["High","O15320","Endoplasmic reticulum export factor CTAGE5 [OS=Homo sapiens]",25,18,32,18,804,90.9,5.22,81.02,"","","","","","","","",1585.5,1673.8,1689.2,1908,1805.5,1803.5,0.8969548667754215,-0.15689270184700688,0.016010143945201286,1.795604763375792,0.07808070201382364,1.1074562906364562,1601]
["High","O15321-1","Transmembrane 9 superfamily member 1 [OS=Homo sapiens]",5,3,3,3,606,68.8,7.17,4.2,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","TM9SF1","ENSCANG00000029500; ENSCCAG00000032112; ENSG00000100926; ENSG00000285465; ENSPPAG00000042444; ENSPTRG00000032568; ENSRBIG00000029944; ENSRROG00000042511","","","",133.1,120.6,134.9,130.8,131.9,136.4,0.9736908043096968,-0.038464377925927044,0.5073014832698138,0.29473386787192446,0.6749037282962526,0.17075817272686253,5869]
["High","O15344-1","E3 ubiquitin-protein ligase Midline-1 [OS=Homo sapiens]",26,16,36,16,667,75.2,6.8,95.44,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","MID1","ENSCANG00000031338; ENSCCAG00000029160; ENSCJAG00000000987; ENSCSAG00000015273; ENSG00000101871; ENSMFAG00000037182; ENSMLEG00000034816; ENSMMUG00000020179; ENSMNEG00000026727; ENSPANG00000006683; ENSPPAG00000038224; ENSRBIG00000037000; ENSTSYG00000003295","","Interferon gamma signaling","Ubiquitin mediated proteolysis",1309.7,1386.4,1353.5,1609.7,1718.6,1674.8,0.809418160740341,-0.30504287608005015,1.1929753803597034E-3,2.9233685188478935,0.022999387086045833,1.6382837374039265,405]
["High","O15347","High mobility group protein B3 [OS=Homo sapiens]",13,2,5,2,200,23,8.37,4.96,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","HMGB3","ENSG00000029993","","","",123.7,122,146.9,213.3,158.7,108.8,0.8165557404326123,-0.2923767232450145,0.39976335071284397,0.3981970234063741,0.5823418362622921,0.2348220084405087,5360]
["High","O15355","Protein phosphatase 1G [OS=Homo sapiens]",56,25,161,25,546,59.2,4.36,383.7,"protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","PPM1G","ENSG00000115241","VEGFA-VEGFR2 signaling pathway; mRNA processing","","",6050.7,5358.4,5997,5994.7,5335.9,5694.1,1.0224027442480632,0.03196361376428838,0.6864905169587943,0.163365457641957,0.8072466801828714,0.09299373235133906,6640]
["High","O15357","Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [OS=Homo sapiens]",18,18,39,18,1258,138.5,6.54,88.27,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","INPPL1","ENSG00000165458","EGF/EGFR signaling pathway; Insulin signaling","Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; B cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway",1564.6,1526.6,1435.8,1608.1,1491.6,1618.7,0.9594354018311292,-0.05974242092653501,0.31693531000664243,0.49902937303194544,0.5037929357760309,0.29774792650642135,4912]
["High","O15360","Fanconi anemia group A protein [OS=Homo sapiens]",6,5,6,5,1455,162.7,6.6,5.61,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","","FANCA","ENSG00000187741","DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",33.2,26.5,28.7,27.2,24.6,31,1.067632850241546,0.09441560189210645,0.5287365994277402,0.2767606264600901,0.6910571423387672,0.16048604006956416,5974]
["High","O15371","Eukaryotic translation initiation factor 3 subunit D [OS=Homo sapiens]",51,21,82,21,548,63.9,6.05,173.31,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3D","ENSG00000100353","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",2544.2,2537.2,2516.3,2622.5,2659.1,2722.2,0.9492616007396486,-0.07512237004242317,0.011095447278049163,1.9548551858634033,0.064699964411507,1.1890959582167768,1339]
["High","O15372","Eukaryotic translation initiation factor 3 subunit H [OS=Homo sapiens]",55,16,78,16,352,39.9,6.54,148.32,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3H","ENSG00000147677","Translation factors; VEGFA-VEGFR2 signaling pathway; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Measles",4611.8,4340.3,4197.2,4251.1,4263.7,4201.6,1.034042653581202,0.04829569710439175,0.30599362355163406,0.5142876234700305,0.49302480658092424,0.30713122861288256,4846]
["High","O15379","Histone deacetylase 3 [OS=Homo sapiens]",9,4,8,4,428,48.8,5.16,16.06,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","HDAC3","ENSG00000171720","Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome","Cytoprotection by HMOX1; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling","Neutrophil extracellular trap formation; Thyroid hormone signaling pathway; Alcoholism; Viral carcinogenesis",357.2,383,377.4,360.3,390.1,389.1,0.9807810443176832,-0.027996998743196343,0.5912659741444778,0.22821711282650492,0.7381843182155553,0.13183518507478392,6254]
["High","O15381-1","Nuclear valosin-containing protein-like [OS=Homo sapiens]",39,28,85,28,856,95,6.48,180.61,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","NVL","ENSG00000143748","","","Ribosome biogenesis in eukaryotes",2745.4,2646.3,2633.8,3063.6,2987.6,3018.3,0.884888913391036,-0.1764317404363665,1.1202454473008422E-3,2.950686812392504,0.02231346033807392,1.651433074754326,392]
["High","O15397-1","Importin-8 [OS=Homo sapiens]",19,15,32,14,1037,119.9,5.16,74.12,"transport;signal transduction","cytosol;nucleus","other molecular function","IPO8","ENSG00000133704","","Transcriptional regulation by small RNAs","Nucleocytoplasmic transport",805.1,813.1,774.1,853.8,936.5,945.8,0.8743466978546107,-0.19372264113822008,0.0221510146062429,1.6546063765379346,0.09399734893779596,1.0268843948888358,1840]
["High","O15400","Syntaxin-7 [OS=Homo sapiens]",39,7,19,7,261,29.8,5.55,35.83,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STX7","ENSG00000079950","","","SNARE interactions in vesicular transport; Phagosome",350.9,365.1,339.7,327.9,356.8,332.5,1.0378489972473457,0.05359655278071462,0.33038094940555984,0.4809850031391103,0.5176830128353624,0.28593608565153183,4983]
["Low","O15417-1","Trinucleotide repeat-containing gene 18 protein [OS=Homo sapiens]",0,1,2,1,2968,314.3,8.7,2.13,"","other membranes;cytosol;mitochondrion;nucleus","other molecular function","TNRC18","ENSG00000182095","","","",128.6,153.2,126.7,124.7,151.4,140.9,0.9796163069544364,-0.029711305298980323,0.8181163589136328,0.08718492317431563,0.8954096622368439,0.04797822351801545,7134]
["Medium","O15427","Monocarboxylate transporter 4 [OS=Homo sapiens]",2,1,1,1,465,49.4,7.96,2.4,"transport","plasma membrane;other membranes;nucleus;other cell component","transporter activity","SLC16A3","ENSG00000141526","Metabolic reprogramming in colon cancer","Pyruvate metabolism; Basigin interactions; Proton-coupled monocarboxylate transport","Central carbon metabolism in cancer",100.5,90.8,92.9,67.5,49.2,51.2,1.6926742108397859,0.7593043243057505,0.003972082604337644,2.4009817283954407,0.03838368932508456,1.4158532845113914,808]
["Medium","O15431","High affinity copper uptake protein 1 [OS=Homo sapiens]",6,1,2,1,190,21.1,7.42,5.3,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","SLC31A1","ENSG00000136868","Copper homeostasis","Metal ion SLC transporters","Platinum drug resistance; Mineral absorption",80.7,81.1,65.5,78.9,85.4,87.7,0.901984126984127,-0.14882604956943102,0.22685241699108474,0.6442565891980572,0.406999924601652,0.39040567122954534,4352]
["High","O15439-1","multidrug resistance-associated protein 4 [OS=Homo sapiens]",10,9,10,9,1325,149.4,8.19,16.16,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","ABCC4","ENSG00000125257","Fluoropyrimidine activity; Drug induction of bile acid pathway; Ectoderm differentiation; Pregnane X receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; TYROBP causal network in microglia; Aspirin and miRNAs; Proximal tubule transport; FOXA2 pathway; Prostaglandin synthesis and regulation","ABC-family proteins mediated transport; Platelet degranulation","Antifolate resistance; ABC transporters; cAMP signaling pathway; Bile secretion",201.8,228.2,225.8,245.1,251.4,260.2,{"$f":"AVERAGE(T322:V322)/AVERAGE(W322:Y322)","v":0.8666578564820933},{"$f":"LOG(Z322,2)","v":-0.2064655433991936},{"$f":"TTEST(T322:V322,W322:Y322,2,2)","v":0.023990785681249783},{"$f":"-LOG10(AB322)","v":1.6199555289623926},{"$f":"AB322*7808/AF322","v":0.09827914721888684},{"$f":"-LOG10(AD322)","v":1.0075386206060648},1906]
["High","O15440","Multidrug resistance-associated protein 5 [OS=Homo sapiens]",9,8,12,8,1437,160.6,8.66,25.56,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","ABCC5","ENSG00000114770","Fluoropyrimidine activity; Nuclear receptors meta-pathway; NRF2 pathway","ABC-family proteins mediated transport; Hyaluronan biosynthesis and export","Antifolate resistance; ABC transporters",193,178.4,186.8,175.9,168,162.2,1.1029440821971945,0.14135965005734583,0.04020633699016928,1.395705491617823,0.1346765676616224,0.8707079604797643,2331]
["High","O15446-1","DNA-directed RNA polymerase I subunit RPA34 [OS=Homo sapiens]",10,3,3,3,510,55,8.51,5.83,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytosol;mitochondrion;nucleus;other cell component","other molecular function","POLR1G","ENSG00000117877","","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase",61.6,49.6,54.4,198,68.1,54.9,0.5158878504672897,-0.9548706245103403,0.3211973566852965,0.4932280374335601,0.5082912365218474,0.2938873779286419,4934]
["High","O15460-1","Prolyl 4-hydroxylase subunit alpha-2 [OS=Homo sapiens]",13,6,8,6,535,60.9,5.71,16.6,"protein metabolism;other metabolic processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","P4HA2","ENSG00000072682","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","Arginine and proline metabolism; Metabolic pathways",505.4,517.5,513.5,580.7,593.9,579.3,0.8759906494098866,-0.19101262474354402,2.4473654637217955E-4,3.6113011728523707,0.012824852040764953,1.8919476366060093,149]
["High","O15484","calpain-5 [OS=Homo sapiens]",28,13,18,13,640,73.1,7.64,34.33,"protein metabolism;signal transduction","other cell component","other molecular function","CAPN5","ENSG00000149260","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",867.1,953.5,892.1,695.3,734.1,730.9,1.2557052261260009,0.3284978346772095,2.9639695167118928E-3,2.528126267221688,0.03320326253441386,1.478819240661062,697]
["High","O15488-1","Glycogenin-2 [OS=Homo sapiens]",10,4,10,4,501,55.1,5.1,27.53,"other metabolic processes","cytosol;other cell component","other molecular function","GYG2","ENSG00000056998","Glycogen synthesis and degradation","Glycogen synthesis; Glycogen storage disease type 0 (liver GYS2); Glycogen storage disease type IV (GBE1); Glycogen breakdown (glycogenolysis)","Starch and sucrose metabolism; Metabolic pathways",719.5,784.2,756.6,776,774.1,814.3,0.955971916765353,-0.06495985757930568,0.20372411716291347,0.6909575555320543,0.37936511013785557,0.4209426132769871,4193]
["High","O15498","Synaptobrevin homolog YKT6 [OS=Homo sapiens]",34,7,37,7,198,22.4,6.92,81.66,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","YKT6","ENSG00000106636","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport","SNARE interactions in vesicular transport",1715.5,1872.6,1853.5,1650.7,1675.7,1691.6,1.0844161020326823,0.116918440411307,0.05012987654236266,1.299903364946824,0.1535559341085789,0.8137333957574561,2549]
["High","O15504","nucleoporin-like protein 2 [OS=Homo sapiens]",17,7,10,7,423,44.8,9.19,20.54,"transport","other membranes;cytosol;nucleus","other molecular function","NUP42","ENSG00000136243","","HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus","Nucleocytoplasmic transport",325.4,332.9,325.4,377.7,322.1,364.1,0.9246169752796314,-0.1130722452629671,0.1892496237717172,0.7229649752045321,0.36181710636865033,0.44151090396076925,4084]
["High","O15511-1","Actin-related protein 2/3 complex subunit 5 [OS=Homo sapiens]",40,4,5,4,151,16.3,5.67,16.5,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","Arpc5; ARPC5","ENSDLEG00000020693; ENSG00000162704; ENSGGOG00000007894; ENSPCTG00005002795; ENSPPAG00000038421; ENSPPYG00000000425; ENSPTRG00000001767; ENSRNOG00000028062; ENSSBOG00000027275; ENSSSCG00000015560; ENSSSCG00070012419; ENSSTOG00000001001","Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton","Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Neutrophil degranulation; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",78.3,81.5,101.9,111.9,95,93.3,0.8717521652231848,-0.19801005257265325,0.2472785301439024,0.6068135894405845,0.43010709809837155,0.366423390183602,4489]
["High","O15514","DNA-directed RNA polymerase II subunit RPB4 [OS=Homo sapiens]",11,1,3,1,142,16.3,4.79,2.94,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","POLR2D","ENSG00000144231","Pyrimidine metabolism","Estrogen-dependent gene expression; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; mRNA Splicing - Major Pathway; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere","RNA polymerase; Huntington disease",27.8,19.6,31,38.3,23.7,18.6,0.9727047146401987,-0.03992618441275888,0.9194275840880526,0.036482470960382554,0.9552748604869613,0.019871651224674138,7515]
["High","O15523","atp-dependent rna helicase ddx3y [OS=Homo sapiens]",60,37,183,9,660,73.1,7.55,381.16,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX3Y","ENSG00000067048","Novel intracellular components of RIG-I-like receptor (RLR) pathway","","",724.1,785.8,801.7,756,809,772,0.9891313649978606,-0.01576595909458492,0.7804350298242685,0.1076632455333458,0.8713909213310294,0.05978696911494955,6993]
["Medium","O15525","transcription factor MafG [OS=Homo sapiens]",6,1,2,1,162,17.8,10.04,2.33,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","MAFG","ENSG00000197063","Quercetin and Nf-kB / AP-1 induced apoptosis; Nuclear receptors meta-pathway; NRF2 pathway; Ethanol metabolism production of ROS by CYP2E1","Factors involved in megakaryocyte development and platelet production","",115.5,110.9,140.7,146.3,129.3,129.7,0.9057488280286209,-0.14281706094729318,0.3046751441037831,0.5161629747858122,0.4916105652329693,0.3083787922358008,4839]
["Medium","O15527-1","N-glycosylase/DNA lyase [OS=Homo sapiens]",3,1,1,1,345,38.8,8.6,2.96,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","OGG1","ENSG00000114026","Base excision repair; DNA repair pathways, full network","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Defective OGG1 Substrate Binding; Defective OGG1 Substrate Processing","Base excision repair",111.2,114.8,121.8,131.1,147.9,144.9,0.820476527482897,-0.28546603374850826,0.013674681885657543,1.8640827678764684,0.07118127744214274,1.147634222273514,1500]
["High","O15530-1","3-phosphoinositide-dependent protein kinase 1 [OS=Homo sapiens]",10,5,8,5,556,63.1,7.36,12.47,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function","PDPK1","ENSG00000140992","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; Serotonin HTR1 group and FOS pathway","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of TP53 Degradation; PIP3 activates AKT signaling; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ","Platinum drug resistance; PPAR signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Thyroid hormone signaling pathway; Insulin resistance; Aldosterone-regulated sodium reabsorption; Toxoplasmosis; Proteoglycans in cancer; Chemical carcinogenesis; Endometrial cancer; Prostate cancer; Non-small cell lung cancer; Choline metabolism in cancer; Lipid and atherosclerosis",406.5,386.5,391.3,304.7,285.9,297.7,1.3332207587526737,0.4149156860444329,2.6712173067396273E-4,3.57329078016319,0.013117524988064785,1.8821480998250064,159]
["High","O15540","Fatty acid-binding protein, brain [OS=Homo sapiens]",22,2,4,2,132,14.9,5.59,9.22,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus","other molecular function","FABP7","ENSG00000164434","PPAR signaling pathway; Fatty acid transporters","Triglyceride catabolism; NOTCH3 Intracellular Domain Regulates Transcription","PPAR signaling pathway",143.4,174.6,163.9,155.7,150.9,137.6,1.0848716794236828,0.1175244081930082,0.3027884974281951,0.518860627185003,0.48947672627729755,0.3102679532778798,4830]
["High","O15541","RING finger protein 113A [OS=Homo sapiens]",22,5,10,5,343,38.8,5.69,21.61,"protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","RNF113A","ENSG00000125352","","","",473.7,435,434.2,456,382.5,435.2,1.0543299050011778,0.07632636397464299,0.4162311707304775,0.38066539945033934,0.5975239898995345,0.22364465360687505,5439]
["High","O15550","Lysine-specific demethylase 6A [OS=Homo sapiens]",8,9,11,9,1401,154.1,7.44,21.8,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6A","ENSG00000147050","Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Malignant pleural mesothelioma","Activation of anterior HOX genes in hindbrain development during early embryogenesis; HDMs demethylate histones","Transcriptional misregulation in cancer",259.2,242.9,235.2,308.3,259.4,276.1,0.8737852571699453,-0.19464933058753942,0.09073635283131685,1.0422186812862988,0.2248395566191438,0.648127279801663,3151]
["Medium","O15554","intermediate conductance calcium-activated potassium channel protein 4 [OS=Homo sapiens]",3,1,1,1,427,47.7,9.83,0,"cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","KCNN4","ENSG00000104783","","Ca2+ activated K+ channels","Insulin secretion; GnRH secretion; Salivary secretion; Protein digestion and absorption",205.7,185.2,199.9,159.3,259.8,202.1,0.9510624597553121,-0.07238800362251223,0.750531889647428,0.12463085011801227,0.8533789128246858,0.06885809285358224,6867]
["High","O43143","Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [OS=Homo sapiens]",51,42,253,42,795,90.9,7.46,499.59,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","DHX15","ENSG00000109606","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",9481.2,9987.5,9295.9,10102.2,10994.8,10322.3,0.915507347394754,-0.12735663048414952,0.05931480861337002,1.2268368665652296,0.169893626431839,0.7698229134052489,2726]
["High","O43148-1","mRNA cap guanine-N7 methyltransferase [OS=Homo sapiens]",32,18,46,17,476,54.8,6.61,90.23,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNMT","ENSG00000101654","mRNA processing","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA surveillance pathway",2520.8,2403,2538.2,2722.4,2573.6,2665.3,0.937284111891274,-0.0934416674005896,0.05174744508309165,1.2861110876817938,0.15636379690742244,0.8058637923462049,2584]
["High","O43149","Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",2,5,6,3,2961,330.9,5.95,4.67,"","","other molecular function","ZZEF1","ENSG00000074755","","","",211.4,220.8,197.9,222.7,222,204.4,0.9707287012786935,-0.04285994652306593,0.5179923734975957,0.2856766344097727,0.6831899412616939,0.1654585364740571,5920]
["High","O43149-3","Isoform 3 of Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",2,3,3,1,1085,119.9,5.67,5.48,"","","","ZZEF1","","","","",64.7,81.9,74.2,80.3,81.9,74,0.9348010160880611,-0.09726879261898799,0.4056489694030533,0.391849623058828,0.5875175576143647,0.23097915022882878,5391]
["High","O43150-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [OS=Homo sapiens]",7,6,8,6,1006,111.6,6.68,19.9,"other biological processes","plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","ASAP2","ENSG00000151693","Vitamin D receptor pathway","","Endocytosis; Fc gamma R-mediated phagocytosis",296.8,353.9,303,331.3,374.3,336.5,0.9151712887438828,-0.1278863030819883,0.26228135143784737,0.5812325872424917,0.4465531600581579,0.3501268329777764,4586]
["High","O43156","TELO2-interacting protein 1 homolog [OS=Homo sapiens]",10,9,12,9,1089,122,5.97,23.39,"other biological processes","nucleus;other cell component","","TTI1","ENSG00000101407","Fragile X syndrome; Malignant pleural mesothelioma","","mTOR signaling pathway",423.1,401.3,378.5,397.8,488.1,427.9,0.9155883696148576,-0.12722895790632013,0.27847034233728285,0.5552210512806349,0.4631089314099051,0.3343168432241292,4695]
["High","O43157","Plexin-B1 [OS=Homo sapiens]",8,11,15,11,2135,232.2,5.49,34.98,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PLXNB1","ENSG00000164050","","RHOD GTPase cycle; G alpha (12/13) signalling events; Sema4D induced cell migration and growth-cone collapse; Sema4D mediated inhibition of cell attachment and migration","Axon guidance",399,387.7,387,337.7,384.5,365.3,1.079264367816092,0.11004829895090695,0.11173078780391828,0.9518271390511458,0.2579520967395014,0.5884609376542334,3382]
["High","O43159","ribosomal rna-processing protein 8 [OS=Homo sapiens]",22,8,17,8,456,50.7,9.42,31.67,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RRP8","ENSG00000132275","","SIRT1 negatively regulates rRNA expression","",739,717.9,714,774.5,689.5,706.5,1.0001842893342547,2.6584881282001676E-4,0.9963105454306187,1.6052728756797239E-3,0.9986126750606252,6.0292588960879313E-4,7790]
["High","O43164","E3 ubiquitin-protein ligase Praja-2 [OS=Homo sapiens]",19,8,12,7,708,78.2,4.39,16.29,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","PJA2","ENSG00000198961","","Antigen processing: Ubiquitination & Proteasome degradation","",138.3,148.4,164.9,228.4,183.8,181.4,0.7607816711590296,-0.3944456058478026,0.05073654351716535,1.2946791228957986,0.15474645772735432,0.8103792835490126,2560]
["High","O43166-1","Signal-induced proliferation-associated 1-like protein 1 [OS=Homo sapiens]",3,5,5,5,1804,199.9,8.19,7.08,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","SIPA1L1","ENSG00000197555","","Neurexins and neuroligins","Rap1 signaling pathway",520.7,476.4,494.8,450.3,470,465.8,1.0763292691724984,0.10611949270294097,0.06765991856415035,1.1696685292669478,0.18614821851616842,0.7301411157297675,2838]
["High","O43167-1","Zinc finger and BTB domain-containing protein 24 [OS=Homo sapiens]",6,4,5,4,697,78.2,7.61,11.48,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB24","ENSG00000112365","","","",115.9,120.9,118.2,142.6,148.8,138.4,0.8259655653792463,-0.27584645814837655,1.7374769230138996E-3,2.760080954953261,0.02724140525078821,1.5647704930543431,498]
["High","O43169","Cytochrome b5 type B [OS=Homo sapiens]",64,6,33,6,146,16.3,4.97,87.14,"","other membranes","other molecular function","","","","","",872.9,1087.8,1005.2,929.5,1100.5,933.6,1.0007760831421244,1.119217053870514E-3,0.9931713522872445,0.002975816023437179,0.9966176479448406,1.4714266801126028E-3,7781]
["High","O43172-2","Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",37,16,46,16,521,58.3,7.42,115.97,"","","","PRPF4","","","","",1978.3,1946.6,1945.7,1906.1,1836.5,1918.3,1.037043579642813,0.05247652174372774,0.06474527655637466,1.1887919097228212,0.1807404788531188,0.7429445714357131,2797]
["High","O43175","D-3-phosphoglycerate dehydrogenase [OS=Homo sapiens]",65,24,440,24,533,56.6,6.71,1021.72,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PHGDH","ENSG00000092621","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",13432.5,13315.9,13388.4,13721.8,13612.2,13820.3,0.975275973592067,-0.036117579208930134,0.00797465117412104,2.0982883046930536,0.053816833506946486,1.2690818589861679,1157]
["High","O43181","NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [OS=Homo sapiens]",17,3,8,3,175,20.1,10.3,11.75,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity","NDUFS4","ENSG00000164258","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",285.1,263.7,278.3,313.4,312,305.9,0.8881133898851068,-0.1711842104499331,0.00665712924624412,2.1767130112643813,0.04950368109968961,1.305362505675684,1050]
["High","O43237","Cytoplasmic dynein 1 light intermediate chain 2 [OS=Homo sapiens]",24,9,23,9,492,54.1,6.38,49.13,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYNC1LI2","ENSG00000135720","Intraflagellar transport proteins binding to dynein","COPI-mediated anterograde transport; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection",538.4,547.5,582.5,507.4,515.4,489.9,1.102928538375091,0.1413393179721145,0.028083817434673176,1.5515438588595438,0.10738415598919107,0.9690597919517999,2042]
["High","O43242","26S proteasome non-ATPase regulatory subunit 3 [OS=Homo sapiens]",52,26,184,26,534,60.9,8.44,350.11,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity","PSMD3","ENSG00000108344","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Ub-specific processing proteases; Degradation of beta-catenin by the destruction complex; Degradation of AXIN; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",5944.1,6414.4,5942.7,5895.7,6381,6194.2,0.9908125754565289,-0.013315915409225346,0.8021064925755903,0.0957679682898426,0.8868376513778263,0.05215587685828549,7062]
["High","O43251-8","Isoform 8 of RNA binding protein fox-1 homolog 2 [OS=Homo sapiens]",13,4,13,4,451,47.3,6.62,36.56,"","","","RBFOX2","","","","",180.8,193.2,199.2,273.5,256.7,255,0.7300050942435049,-0.45402156320402526,9.1222190590049053E-4,3.0398995029156524,0.02040867805521785,1.6901851252161968,349]
["High","O43252","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [OS=Homo sapiens]",51,23,86,22,624,70.8,6.86,180.9,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS1","ENSG00000138801","Sulfation biotransformation reaction","Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways",3451.7,3417.2,3426.2,3298.2,3419.5,3388.1,1.018731817372202,0.02677430992427836,0.17027508868197466,0.7688488848578204,0.3381250998038805,0.4709225893592831,3932]
["High","O43257","zinc finger HIT domain-containing protein 1 [OS=Homo sapiens]",15,1,1,1,154,17.5,9.41,2.48,"cell organization and biogenesis","nucleus","other molecular function","ZNHIT1","ENSG00000106400","","","",12.7,16.8,12.6,14.8,13.8,12.8,1.0169082125603863,0.02418946556707064,0.883860963428861,0.05361604671166322,0.932592757088182,0.030307961784004002,7400]
["High","O43264","Centromere/kinetochore protein zw10 homolog [OS=Homo sapiens]",29,17,52,17,779,88.8,6.27,88.63,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity","ZW10","ENSG00000086827","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",1469.7,1379.6,1425.6,1522.7,1573.8,1587.2,0.9127185771932446,-0.13175799905282023,0.01391896287171822,1.8563931236241762,0.07202071709898997,1.1425425587411306,1509]
["High","O43272","Proline dehydrogenase 1, mitochondrial [OS=Homo sapiens]",23,8,13,8,600,68,7.87,30.11,"other metabolic processes;stress response;signal transduction;other biological processes","other membranes;mitochondrion;nucleus;other cell component","other molecular function","PRODH","ENSG00000100033","22q11.2 copy number variation syndrome","Proline catabolism","Arginine and proline metabolism; Metabolic pathways",290.6,318.5,307.9,235.7,307.2,256.7,1.1468234117058531,0.19764326173778937,0.1601309294228749,0.7955247756362759,0.32483821692226744,0.48833288207223136,3849]
["High","O43278","Kunitz-type protease inhibitor 1 [OS=Homo sapiens]",4,2,2,2,529,58.4,6.29,5.43,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","enzyme regulator activity","SPINT1","ENSG00000166145","","MET Receptor Activation; Signaling by MST1","Transcriptional misregulation in cancer; Prostate cancer",82.9,88.9,75.8,120.6,108.3,122.3,0.7050113895216402,-0.5042815303210932,0.00402588998963152,2.3951380966974254,0.03847509062306354,1.4148203485712054,817]
["High","O43286","Beta-1,4-galactosyltransferase 5 [OS=Homo sapiens]",8,2,2,2,388,45.1,8.15,3.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","B4GALT5","ENSG00000158470","","N-Glycan antennae elongation; Keratan sulfate biosynthesis; O-linked glycosylation of mucins","Mucin type O-glycan biosynthesis; Metabolic pathways",32.6,42,40.6,65.1,81.1,80.9,0.5072655217965654,-0.9791869892645755,0.003525028231900674,2.452837400400362,0.03621502688773745,1.441111188022518,760]
["High","O43290","U4/U6.U5 tri-snRNP-associated protein 1 [OS=Homo sapiens]",48,33,95,33,800,90.2,6.13,228.79,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","SART1","ENSG00000175467","","mRNA Splicing - Major Pathway","Spliceosome",3798.9,3641,3728.4,3804.8,3481.3,3661.3,1.02017830717796,0.02882132905910464,0.5185171826636863,0.28523684735135635,0.683189700006423,0.16545868983675321,5926]
["High","O43291","Kunitz-type protease inhibitor 2 [OS=Homo sapiens]",20,4,7,4,252,28.2,8.29,13.65,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity","SPINT2","ENSG00000167642","","MET Receptor Activation; Signaling by MST1","",263.7,305,292.7,344.4,360.5,342.7,0.8222604047346317,-0.2823327361087375,0.01003057908134761,1.9986739937418763,0.0610434617826673,1.2143608454581694,1283]
["High","O43293-1","Death-associated protein kinase 3 [OS=Homo sapiens]",26,8,16,8,454,52.5,6.89,29.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","DAPK3","ENSG00000167657; ENSPTRG00000010286","Bladder cancer","Caspase activation via Dependence Receptors in the absence of ligand","Autophagy; Pathways in cancer; Bladder cancer",453.4,402.1,440.2,419.8,395.1,385.5,1.079390203265578,0.11021649832988967,0.16045564477750646,0.7946449999608067,0.32541238296695335,0.48756592481067207,3850]
["High","O43295","SLIT-ROBO Rho GTPase-activating protein 3 [OS=Homo sapiens]",2,2,2,2,1099,124.4,6.68,6.04,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity","SRGAP3","ENSG00000196220","","CDC42 GTPase cycle; RAC1 GTPase cycle; Inactivation of CDC42 and RAC1","Axon guidance",44.8,56,49.4,63.1,69.8,61,0.7746260959257347,-0.368427990592521,0.02554534117060935,1.5926882927263413,0.10239118267973193,0.9897374406103026,1948]
["High","O43296","Zinc finger protein 264 [OS=Homo sapiens]",3,1,1,1,627,70.5,7.49,4.98,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF264","ENSG00000083844","","Generic Transcription Pathway","",33.2,35,35.4,16.3,8.2,20.5,2.302222222222222,1.2030270964695167,0.006010795244886693,2.2210680658311523,0.047310775475882354,1.3250399333266958,992]
["High","O43298","Zinc finger and BTB domain-containing protein 43 [OS=Homo sapiens]",4,2,2,2,467,52.6,5.76,2.27,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB43","ENSG00000169155","","","",109,91,108.6,119.2,88.7,117.7,0.9477886977886978,-0.07736263769551212,0.6498000016410884,0.1872202918942129,0.7820034545027156,0.10679132843867711,6488]
["High","O43301","Heat shock 70 kDa protein 12A [OS=Homo sapiens]",8,4,7,4,675,74.9,6.77,0,"","nucleus;other cell component","other molecular function","HSPA12A","ENSG00000165868","","Regulation of HSF1-mediated heat shock response","",309.3,269.1,313,253.4,327.5,283.3,1.0314741957880122,0.04470773002292093,0.7421200688034384,0.12952582383118189,0.8482613815279237,0.0714703045073517,6831]
["High","O43303","centriolar coiled-coil protein of 110 kDa [OS=Homo sapiens]",6,4,4,4,1012,113.4,8.65,8.68,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cell component","","CCP110","ENSG00000103540","Joubert syndrome","Ub-specific processing proteases; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; RHOV GTPase cycle","",164.8,180.2,166,181.1,169.7,163.8,0.9930042751651771,-0.010128165908815918,0.8737763233800736,0.05859972749632499,0.9273407004147907,0.03276067888018863,7357]
["High","O43310","CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",10,4,4,4,598,67.5,6.54,5.41,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","CTIF","ENSG00000134030; ENSG00000282825","","","",62.5,73,73.9,97.1,85.8,75.9,0.8091190108191655,-0.30557617506169893,0.08220290974640572,1.0851128094132094,0.21210849943818108,0.6734419284417419,3026]
["High","O43314-1","inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 [OS=Homo sapiens]",12,12,15,12,1243,140.3,8.22,33.34,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","PPIP5K2","ENSG00000145725","","Synthesis of pyrophosphates in the cytosol","Phosphatidylinositol signaling system",696.9,657,695.6,722.5,718.4,706.1,0.9545877969259432,-0.06705020122399445,0.08079682383974889,1.092605711205396,0.2094494025699732,0.6789208740754235,3012]
["High","O43318","mitogen-activated protein kinase kinase kinase 7 [OS=Homo sapiens]",5,4,5,4,606,67.2,7.11,2.45,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","signal transduction activity or receptor binding;kinase activity;other molecular function","MAP3K7","ENSG00000135341","IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL-6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway","Downstream TCR signaling; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway","MAPK signaling pathway; NF-kappa B signaling pathway; Autophagy; AMPK signaling pathway; Wnt signaling pathway; Osteoclast differentiation; Adherens junction; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; T cell receptor signaling pathway; TNF signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Leishmaniasis; Toxoplasmosis; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",308.6,315.9,306.4,348.8,298.1,347.2,0.9364249069510108,-0.09476478724560684,0.28022695672149706,0.5524900896345148,0.46494094306873124,0.3326022078158819,4706]
["Low","O43323","desert hedgehog protein [OS=Homo sapiens]",2,1,1,1,396,43.6,9.28,0,"cell-cell signaling;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","DHH","ENSG00000139549","Hedgehog signaling pathway; Hedgehog signaling pathway; Somatic sex determination; Mammalian disorder of sexual development","Release of Hh-Np from the secreting cell; Activation of SMO; Class B/2 (Secretin family receptors); Ligand-receptor interactions; HHAT G278V doesn't palmitoylate Hh-Np; Transcriptional regulation of testis differentiation","Hedgehog signaling pathway",33.3,27.5,23,51.5,36.8,40.4,0.6511266511266511,-0.6189899045213502,0.04853421572892696,1.3139519838074756,0.15091802326223086,0.8212588918617626,2511]
["High","O43324-1","Eukaryotic translation elongation factor 1 epsilon-1 [OS=Homo sapiens]",43,6,18,6,174,19.8,8.54,38.05,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EEF1E1","ENSANAG00000036153; ENSG00000124802; ENSPTRG00000017709","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","",799.2,768.4,792.7,853.7,813.5,818.1,0.9497042610550035,-0.07444976832147956,0.05761905769378923,1.2394338484807002,0.16674929669129218,0.7779359891579503,2698]
["High","O43347","RNA-binding protein Musashi homolog 1 [OS=Homo sapiens]",25,7,21,6,362,39.1,7.85,39.55,"developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MSI1","ENSG00000135097","","Regulation of expression of SLITs and ROBOs","mRNA surveillance pathway",845.4,878.6,823.1,971.5,1065.2,1009.4,0.8361839729490167,-0.2581077032256685,0.006260744961555077,2.2033739873257723,0.04859234260419686,1.3134321633870456,1006]
["Medium","O43353-1","Receptor-interacting serine/threonine-protein kinase 2 [OS=Homo sapiens]",1,1,1,1,540,61.2,7.09,2.02,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","RIPK2","ENSG00000104312","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor (TCR) signaling pathway","Downstream TCR signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases","NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Shigellosis; Salmonella infection; Tuberculosis",36.2,32.2,34.6,48.8,48.9,40.7,0.7442196531791909,-0.42619960556614356,0.016221811919064758,1.789900638256644,0.07881761509897799,1.1033767103613532,1607]
["High","O43379-1","Wd repeat-containing protein 62 [OS=Homo sapiens]",4,5,6,1,1518,165.8,5.91,8.62,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;nucleus","","WDR62","ENSG00000075702","","","",156.6,159.2,163.3,185.9,166.1,167,0.9231213872832369,-0.11540772511285453,0.1198532103838007,0.9213503284780864,0.2703882885514926,0.5680121231135787,3461]
["High","O43390-1","heterogeneous nuclear ribonucleoprotein r [OS=Homo sapiens]",58,28,215,20,633,70.9,8.13,525.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","Hnrnpr; HNRNPR; LOC111154612","ENSAMEG00000009537; ENSCAFG00000013308; ENSCANG00000026442; ENSCATG00000035305; ENSFCAG00000019123; ENSG00000125944; ENSG00000282958; ENSGGOG00000013250; ENSLCNG00005013650; ENSMFAG00000039737; ENSMMUG00000010970; ENSMPUG00000015898; ENSNLEG00000008411; ENSRROG00000036942; ENSSSUG00005005658; ENSUAMG00000027050; ENSUMAG00000013292","mRNA Processing; mRNA processing","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","",4367.5,4482.5,4436.5,4761.6,4992.2,4991.2,0.9010851135978297,-0.15026471008494743,0.004364672265963602,2.3600483609909775,0.039952357623263546,1.3984575874998653,853]
["High","O43395","U4/U6 small nuclear ribonucleoprotein Prp3 [OS=Homo sapiens]",42,25,86,25,683,77.5,9.5,169.89,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","PRPF3","ENSG00000117360","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",3569.8,3553.4,3690.6,3873.6,3555.1,3684.2,0.973085333261345,-0.0393617693518495,0.38414323341997764,0.4155068123893266,0.5678512621247984,0.24576540460159643,5282]
["High","O43396","Thioredoxin-like protein 1 [OS=Homo sapiens]",52,12,49,12,289,32.2,4.96,135.55,"","cytosol;nucleus;other cell component","other molecular function","TXNL1","ENSG00000091164","","RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle","",1908.9,1836.8,1937.3,2071.4,1957.1,2049.9,0.9349499868386417,-0.09703890172633059,0.04595846071512695,1.3376345255477513,0.14569373173516492,0.8365591327282191,2463]
["High","O43399","Tumor protein D54 [OS=Homo sapiens]",60,9,25,9,206,22.2,5.36,49.43,"other metabolic processes;other biological processes","other cell component","other molecular function","TPD52L2","ENSG00000101150","","","",904.1,945.4,1012.4,993.1,939.7,867.2,1.0221071428571429,0.03154643538190737,0.6908559807052036,0.1606124783913191,0.8107926495334781,0.09109019717873294,6653]
["High","O43402","ER membrane protein complex subunit 8 [OS=Homo sapiens]",42,7,21,7,210,23.8,6.4,44.2,"cell organization and biogenesis","other membranes;cytosol;ER/Golgi;other cell component","","EMC8","ENSG00000131148","","","",598.2,613.6,558.5,585.8,572.6,592.9,1.0108490835379431,0.015567623666732498,0.7351277636415061,0.13363717489886706,0.8423653622707484,0.07449949947209025,6814]
["High","O43414-1","ERI1 exoribonuclease 3 [OS=Homo sapiens]",3,1,4,1,337,37.2,8.07,8.71,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","ERI3","ENSG00000117419; ENSMFAG00000044436; ENSMLEG00000012810; ENSMMUG00000011651; ENSMNEG00000035539; ENSNLEG00000014004; ENSPANG00000013867; ENSPPAG00000042776; ENSPTRG00000000655; ENSRBIG00000044795; ENSRROG00000036414","","","",232.3,244.6,234.9,266.2,249,263.1,0.9145573686239239,-0.12885442427551794,0.026792808643665574,1.5719817576680237,0.1047562593338712,0.979820017880091,1997]
["High","O43422-1","52 kDa repressor of the inhibitor of the protein kinase [OS=Homo sapiens]",10,4,6,4,761,87.6,5.86,13.15,"other metabolic processes;signal transduction;other biological processes","","nucleic acid binding activity;kinase activity;other molecular function","THAP12","ENSG00000137492; ENSPTRG00000004091","","","",84.6,78.2,90,73.1,74.9,76.1,{"$f":"AVERAGE(T386:V386)/AVERAGE(W386:Y386)","v":1.1280678268630076},{"$f":"LOG(Z386,2)","v":0.1738538146667096},{"$f":"TTEST(T386:V386,W386:Y386,2,2)","v":0.05311150607581128},{"$f":"-LOG10(AB386)","v":1.2748113831762264},{"$f":"AB386*7808/AF386","v":0.15876517589584013},{"$f":"-LOG10(AD386)","v":0.7992447511206273},2612]
["High","O43426","Synaptojanin-1 [OS=Homo sapiens]",6,7,8,7,1573,173,7.42,17.28,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ1","ENSG00000159082","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway","Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Clathrin-mediated endocytosis; Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",260.6,247.4,221.9,187.9,200.1,207.7,1.2252811818029208,0.29311286191601843,0.024634436626598668,1.6084573653053356,0.10007579665998043,0.9996709439792267,1922]
["High","O43427","Acidic fibroblast growth factor intracellular-binding protein [OS=Homo sapiens]",23,8,15,8,364,41.9,6.48,25.79,"signal transduction","other membranes;mitochondrion;nucleus;other cell component","other molecular function","FIBP","ENSG00000172500","Modulators of TCR signaling and T cell activation","","",714.6,782.5,773.4,770.4,804.5,753.4,0.9751750204011511,-0.03626692381535687,0.500575944721533,0.3005300243356921,0.670066342599988,0.1738821961070721,5833]
["High","O43432","Eukaryotic translation initiation factor 4 gamma 3 [OS=Homo sapiens]",23,32,66,25,1585,176.5,5.38,113.78,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","nucleic acid binding activity","EIF4G3","ENSG00000075151","Translation factors; Translation inhibitors in chronically activated PDGFRA cells","ISG15 antiviral mechanism","Viral myocarditis",1541.2,1594.1,1599.4,1667.7,1591.8,1654.6,0.9634928064141959,-0.053654199709706044,0.11609856232132357,0.9351731582095899,0.26482546731080764,0.5770402526888315,3423]
["High","O43439","Protein CBFA2T2 [OS=Homo sapiens]",3,2,4,2,604,67.1,8.05,10.01,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","other molecular function","CBFA2T2","ENSG00000078699","","","",206.7,225.4,206.3,241.9,222.5,215.1,0.9395143487858721,-0.09001289943240756,0.2494482530890931,0.6030195331215675,0.43195652253706784,0.36455996376950267,4509]
["High","O43447","peptidyl-prolyl cis-trans isomerase H [OS=Homo sapiens]",52,9,51,8,177,19.2,8.07,58.75,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PPIH","ENSG00000171960","","mRNA Splicing - Major Pathway","Spliceosome",1810.2,1700.3,1855.8,1774.6,1707.3,1749.7,1.0257473812982645,0.03667547107877366,0.42129381278109534,0.3754149189760718,0.6022449817273512,0.22022681012115097,5462]
["Medium","O43462","Membrane-bound transcription factor site-2 protease [OS=Homo sapiens]",2,1,1,1,519,57.4,7.49,2.45,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MBTPS2","ENSG00000012174","Sterol regulatory element-binding proteins (SREBP) signaling; Type I collagen synthesis in the context of osteogenesis imperfecta; Unfolded protein response","Regulation of cholesterol biosynthesis by SREBP (SREBF); ATF6 (ATF6-alpha) activates chaperones; CREB3 factors activate genes; Assembly of active LPL and LIPC lipase complexes","Protein processing in endoplasmic reticulum",26.2,36.3,28.5,35.7,37.9,41.9,0.7878787878787878,-0.34395440121736137,0.08316204427645221,1.08007484344987,0.21380613819905792,0.6699798307094997,3037]
["High","O43463","Histone-lysine N-methyltransferase SUV39H1 [OS=Homo sapiens]",3,1,2,1,412,47.9,8.03,7.6,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SUV39H1","ENSG00000101945","Histone modifications; Retinoblastoma gene in cancer; Interactions between LOXL4 and oxidative stress pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","PKMTs methylate histone lysines; SIRT1 negatively regulates rRNA expression","Lysine degradation; Metabolic pathways",80,82.2,92,93,117.7,107.9,0.7978656622724419,-0.3257822365203509,0.056438438416987896,1.248425011152052,0.16461386894278726,0.7835335776803493,2677]
["High","O43464","Serine protease HTRA2, mitochondrial [OS=Homo sapiens]",22,6,12,6,458,48.8,10.07,17.97,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HTRA2","ENSG00000115317","Apoptosis modulation and signaling; Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity","","Apoptosis; Apoptosis; Parkinson disease; Pathways of neurodegeneration",37.9,30,41.9,35.2,37.2,31.8,1.053742802303263,0.07552277672669033,0.6519122662172688,0.18581084730717273,0.7835792756503133,0.10591705888165623,6496]
["High","O43482","Protein Mis18-beta [OS=Homo sapiens]",10,2,2,2,229,24.7,7.37,2.03,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","other molecular function","OIP5","ENSG00000104147","","Deposition of new CENPA-containing nucleosomes at the centromere","",68.8,59,73.6,100.2,88.1,100.1,0.6983356449375867,-0.5180074812340377,0.007868891470215855,2.104086444550375,0.05361283123860855,1.2707312575231107,1146]
["High","O43488","aflatoxin B1 aldehyde reductase member 2 [OS=Homo sapiens]",18,6,11,6,359,39.6,7.17,9.95,"other metabolic processes","cytosol;ER/Golgi","other molecular function","AKR7A2","ENSG00000053371","Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II","Aflatoxin activation and detoxification","Metabolism of xenobiotics by cytochrome P450",460.1,460.2,481.8,448.9,478.2,440.2,1.0254516199809844,0.0362594281805296,0.4408900706579729,0.35566968186546555,0.620936087968516,0.2069530988105805,5544]
["High","O43490-1","Prominin-1 [OS=Homo sapiens]",6,4,4,4,865,97.1,7.27,8.05,"developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","PROM1","ENSG00000007062","Extracellular vesicle-mediated signaling in recipient cells","","Transcriptional misregulation in cancer",40.9,44.1,44.6,55.4,57.4,54,0.776978417266187,-0.364053570560039,1.2353244489078682E-3,2.908218963161632,0.023468158873656046,1.6295209803790658,411]
["High","O43491-1","band 4.1-like protein 2 [OS=Homo sapiens]",54,50,238,7,1005,112.5,5.44,509.23,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","EPB41L2","ENSG00000079819","Splicing factor NOVA regulated synaptic proteins","Neurexins and neuroligins","",8687.2,8554.1,8750.7,10077.3,9320.1,9736.8,0.8921473731902715,-0.16464604728777701,0.009847335618458335,2.006681260134695,0.060685080117539605,1.216918070359501,1267]
["High","O43491-4","Isoform 4 of Band 4.1-like protein 2 [OS=Homo sapiens]",54,44,189,1,852,95.5,5.77,395.37,"","","","EPB41L2","","","","",21,10.9,21.2,26.8,18.9,20.7,0.7996987951807227,-0.3224713805427714,0.3462659559929158,0.46059020510434523,0.5323182879292551,0.2738286132743075,5079]
["High","O43493-1","Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",26,11,21,11,480,51.1,5.73,42.75,"","","","","","","","",1146.8,1041.8,1078.6,1079.1,988.1,1048.1,1.0487593490193563,0.06868367142671461,0.2817831196545401,0.5500850270551441,0.46712581704090217,0.3305661295254048,4710]
["High","O43502","DNA repair protein RAD51 homolog 3 [OS=Homo sapiens]",5,2,2,2,376,42.2,6.74,5.99,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD51C","ENSG00000108384","DNA repair pathways, full network","Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination","Homologous recombination; Fanconi anemia pathway",52,34.9,45.3,48.2,49.7,47.2,0.9110957960027565,-0.13432534255905315,0.44059159313057156,0.3559637938212823,0.6208516800511645,0.20701213932255072,5541]
["High","O43504","Ragulator complex protein LAMTOR5 [OS=Homo sapiens]",11,1,3,1,91,9.6,4.87,9.14,"cell organization and biogenesis;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","LAMTOR5","ENSG00000134248","","Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","mTOR signaling pathway",71.8,70.6,102.7,106.1,69.6,79.5,0.9604231974921629,-0.05825784489802997,0.8348904444168941,0.07837050955446664,0.9055180705663438,0.0431028784598726,7199]
["High","O43505","beta-1,4-glucuronyltransferase 1 [OS=Homo sapiens]",11,4,6,4,415,47.1,7.2,12.9,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B4GAT1","ENSG00000174684","","Keratan sulfate biosynthesis; Defective LARGE causes MDDGA6 and MDDGB6; O-linked glycosylation","Mannose type O-glycan biosynthesis; Metabolic pathways",370.6,374.9,388.8,494.9,464.1,520.2,0.766833423472147,-0.3830148746958056,2.562969050908981E-3,2.5912566381000333,0.03136624192711179,1.50353751216256,638]
["High","O43524","Forkhead box protein O3 [OS=Homo sapiens]",2,1,1,1,673,71.2,5.16,2.2,"RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXO3","ENSG00000118689","IL-5 signaling pathway; Energy metabolism; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Kit receptor signaling pathway; Copper homeostasis; NAD metabolism, sirtuins and aging; Imatinib and chronic myeloid leukemia; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Non-small cell lung cancer; Leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; DNA damage response (only ATM dependent)","MAPK6/MAPK4 signaling; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by NODAL; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; FoxO signaling pathway; Mitophagy; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Neurotrophin signaling pathway; Prolactin signaling pathway; Alcoholic liver disease; Shigellosis; Chemical carcinogenesis; Endometrial cancer; Non-small cell lung cancer",29.5,22.7,18.8,32.5,23.2,27.1,0.8574879227053139,-0.22181174310728097,0.39467818967817364,0.40375687250018255,0.5780617717139711,0.23802575036651108,5331]
["Medium","O43529","Carbohydrate sulfotransferase 10 [OS=Homo sapiens]",2,1,1,1,356,42.2,8.03,2.54,"cell adhesion;protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST10","ENSG00000115526","Metapathway biotransformation Phase I and II","Reactions specific to the complex N-glycan synthesis pathway","Mannose type O-glycan biosynthesis; Metabolic pathways",43.3,54.3,50,57.8,76.4,63.4,0.7469635627530364,-0.4208902255242816,0.059055045422569036,1.2287429921135593,0.1693359510317367,0.7712508287948884,2723]
["High","O43542","DNA repair protein XRCC3 [OS=Homo sapiens]",6,2,2,2,346,37.8,8.48,5,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","XRCC3","ENSG00000126215","Fluoropyrimidine activity; Male infertility","Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange","Homologous recombination",65.7,75.8,68.3,90.5,82.5,89,0.800763358778626,-0.32055213384754494,0.01112888156542965,1.9535484793642128,0.06470164353155228,1.1890846873742928,1343]
["High","O43567","E3 ubiquitin-protein ligase RNF13 [OS=Homo sapiens]",6,1,2,1,381,42.8,4.98,2.91,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RNF13","ENSG00000082996","","","",44.9,43.8,44.1,49.5,59,74.2,0.7268746579091405,-0.4602214872805641,0.08203790683790642,1.085985429000208,0.21189281395645826,0.6738837715193897,3023]
["High","O43572","A-kinase anchor protein 10, mitochondrial [OS=Homo sapiens]",7,3,5,3,662,73.8,6.39,5.68,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","AKAP10","ENSG00000108599","G protein signaling pathways","Factors involved in megakaryocyte development and platelet production","",33.3,39.1,35.6,42.5,38.6,40.2,0.8903544929925804,-0.16754823806967936,0.09443062345214108,1.0248871429948643,0.23048274708168726,0.6373615784203358,3199]
["High","O43583","density-regulated protein [OS=Homo sapiens]",22,5,19,5,198,22.1,5.3,47.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","","nucleic acid binding activity","DENR","ENSG00000139726","","","",744.9,674.9,881.7,1191.7,808.9,788.1,0.825294940294761,-0.2770182993370345,0.3241755332315667,0.48921976611765416,0.5110362534770994,0.2915482894414748,4953]
["High","O43592","Exportin-T [OS=Homo sapiens]",26,19,39,19,962,109.9,5.39,77.6,"transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPOT","ENSG00000184575","","tRNA processing in the nucleus","Nucleocytoplasmic transport",1253.8,1375.7,1222.7,1335.5,1581.2,1433.6,0.8855021492770615,-0.1754322862189305,0.12350381742006845,0.9083196184460278,0.27583461281919175,0.5593512377497579,3496]
["Medium","O43593-1","lysine-specific demethylase hairless [OS=Homo sapiens]",2,1,1,1,1189,127.4,7.08,0,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HR","ENSG00000168453","","","",26.9,27.6,33.3,35.2,37.2,39.2,0.7867383512544802,-0.34604418229382955,0.02725117277316835,1.5646148028201563,0.10559660397662456,0.9763500486386493,2015]
["High","O43597","Protein sprouty homolog 2 [OS=Homo sapiens]",6,2,3,2,315,34.7,8.35,9.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","SPRY2","ENSG00000136158","Glioblastoma signaling pathways; Ectoderm differentiation; EGF/EGFR signaling pathway","EGFR downregulation; Spry regulation of FGF signaling","MicroRNAs in cancer",125.2,112.7,120.4,249.2,229.2,249,0.49257629914764917,-1.0215808822448806,8.3728367433063557E-5,4.077127376744938,0.008071001147127903,2.093072590964953,81]
["High","O43598-1","2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [OS=Homo sapiens]",32,5,17,5,174,19.1,5.05,19.41,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","C6orf108; DNPH1","ENSG00000112667","","Purine catabolism","",755.9,707.6,793.4,825.4,796.7,732.7,0.9584253439782572,-0.061262036564178654,0.4273564786580671,0.36920970781781404,0.6090161316594612,0.21537120359388837,5479]
["High","O43602","Neuronal migration protein doublecortin [OS=Homo sapiens]",10,2,2,2,365,40.5,9.28,2.77,"cell organization and biogenesis;developmental processes;signal transduction","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DCX","ENSG00000077279","","Neurofascin interactions","",105.4,116.2,105.6,117,118.4,104.7,0.9620699794178184,-0.055786257766093,0.48736970984531197,0.31214146582798125,0.6600837284427052,0.1804009728000637,5765]
["High","O43615","Mitochondrial import inner membrane translocase subunit TIM44 [OS=Homo sapiens]",52,24,96,24,452,51.3,8.32,201.09,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus","other molecular function","TIMM44","ENSG00000104980","","Mitochondrial protein import","",3614.6,3718.2,3688.5,3735.9,3845,3829.1,0.9659333917616125,-0.05000438687017576,0.04768409653570622,1.3216264414719165,0.149465044460375,0.8254603643497878,2491]
["High","O43617-1","Trafficking protein particle complex subunit 3 [OS=Homo sapiens]",42,9,25,9,180,20.3,4.96,40.56,"transport","other membranes;cytosol;ER/Golgi;other cell component","","TRAPPC3","ENSCANG00000028241; ENSCATG00000041647; ENSCSAG00000001096; ENSG00000054116; ENSGGOG00000004752; ENSMMUG00000022499; ENSMNEG00000014589; ENSPPAG00000041117; ENSPPYG00000001546; ENSRBIG00000043692; ENSRROG00000034420","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",2012.4,1934.1,1938.5,1695.5,1830.3,1640.2,1.1391792489353465,0.1879947718078064,0.0179695416815441,1.7454629995585098,0.0837648844474605,1.0769380062727385,1675]
["High","O43633","charged multivesicular body protein 2a [OS=Homo sapiens]",14,3,5,3,222,25.1,5.97,7.85,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","CHMP2A","ENSG00000130724","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Endocytosis; Necroptosis",204.4,221.7,236.4,233.3,197.3,196.6,1.056281887755102,0.07899489511007782,0.4832477631803003,0.3158301475233118,0.656893895353723,0.18250477409892032,5744]
["High","O43639","Cytoplasmic protein NCK2 [OS=Homo sapiens]",23,8,13,7,380,42.9,6.95,29.84,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NCK2","ENSG00000071051","Pathogenic Escherichia coli infection; Brain-derived neurotrophic factor (BDNF) signaling pathway; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; ErbB signaling pathway","RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Ephrin signaling; Activation of RAC1; Regulation of cortical dendrite branching","ErbB signaling pathway; Axon guidance; T cell receptor signaling pathway; Pathogenic Escherichia coli infection",388.6,438.5,406.4,453.9,401.6,426.9,0.9618683718028695,-0.05608861496706274,0.48106908697038026,0.3177925495400127,0.6551870628056391,0.18363468665605262,5733]
["High","O43657","Tetraspanin-6 [OS=Homo sapiens]",20,6,20,6,245,27.5,8.1,46.7,"other biological processes","plasma membrane;other membranes","","TSPAN6","ENSG00000000003","","","",578.7,590.8,664.5,580.6,513.2,596.7,1.0848861283643891,0.11754362270167698,0.2662913640073795,0.5746429177696833,0.4504339190142156,0.346368913258723,4616]
["High","O43660-1","Pleiotropic regulator 1 [OS=Homo sapiens]",37,13,32,13,514,57.2,9.17,67.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","","PLRG1","ENSG00000171566","","mRNA Splicing - Major Pathway","Spliceosome",1097.5,1204.2,1122,1135.3,1258.5,1225.6,0.9459302646847544,-0.08019426491870243,0.2536162048087606,0.5958230006555075,0.4366560809585012,0.35986048739298615,4535]
["High","O43663-1","Protein regulator of cytokinesis 1 [OS=Homo sapiens]",24,12,21,12,620,71.6,6.68,31.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","PRC1","ENSG00000198901","","RHO GTPases activate CIT","",506.7,530.8,524,534.7,603.1,591.2,0.9031231925968768,-0.14700529962170852,0.06637674916764444,1.1779840211820893,0.183718418114487,0.73584730267882,2821]
["High","O43670-1","BUB3-interacting and GLEBS motif-containing protein ZNF207 [OS=Homo sapiens]",16,8,37,8,478,50.7,9.1,88.14,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","LOC111151255; Znf207; ZNF207","ENSAMEG00000005671; ENSANAG00000033773; ENSCANG00000036057; ENSCJAG00000014376; ENSECAG00000017464; ENSG00000010244; ENSGGOG00000024003; ENSMFAG00000001904; ENSMLEG00000018149; ENSMMUG00000016875; ENSMNEG00000041308; ENSNLEG00000005954; ENSOCUG00000008195; ENSPCOG00000020744; ENSPPAG00000032098; ENSPTRG00000008989; ENSRROG00000037743; ENSSBOG00000026038; ENSSTOG00000000712","","","",1106.8,1102.7,1164.1,1204.6,1095.8,1188.3,0.9670077679364807,-0.048400616024514974,0.3836668008059064,0.41604577924993635,0.567791959949302,0.24581076146562866,5276]
["High","O43674-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [OS=Homo sapiens]",21,4,13,4,189,21.7,9.63,29.64,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB5","ENSG00000136521; ENSGGOG00000005222; ENSPTRG00000015649","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",796.8,738.6,759.3,731.5,768.9,754.3,1.0177407193861712,0.025370065834009164,0.5455178371194905,0.2631910444598383,0.7047325069869262,0.15197569546819067,6044]
["High","O43676","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [OS=Homo sapiens]",11,1,3,1,98,11.4,9.2,6.82,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB3","ENSG00000119013","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",145.8,156,140.6,162,139.2,155,0.9697501096010522,-0.044315061077430246,0.6013118809578062,0.22090021510770294,0.7466671702478611,0.12687294348041903,6288]
["High","O43678","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [OS=Homo sapiens]",37,3,4,3,99,10.9,9.57,6.95,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;mitochondrion","transporter activity","NDUFA2","ENSG00000131495","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",161.3,136.9,188.2,230.4,135.1,159.3,0.9268292682926832,-0.1096244911744978,0.7113635387470101,0.14790839853565146,0.8251859323334801,0.08344818443376197,6731]
["High","O43681","ATPase ASNA1 [OS=Homo sapiens]",44,10,49,10,348,38.8,4.91,98.01,"cell organization and biogenesis;transport","ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","GET3","ENSG00000198356","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",1481.1,1518.8,1447.5,1451.1,1552,1506.5,0.9862072024126307,-0.020037305801076658,0.5926509738221644,0.22720099764565346,0.7395587028293846,0.13102734796453933,6257]
["High","O43683","Mitotic checkpoint serine/threonine-protein kinase BUB1 [OS=Homo sapiens]",18,14,36,14,1085,122.3,6.47,103.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","BUB1","ENSG00000169679","Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation",1225.4,1358.7,1290.5,903.3,942.2,936.9,1.392538815411156,0.4777175415837822,8.3691298980694212E-4,3.077319691362744,0.01974204418251542,1.7046078804798275,331]
["High","O43684","Mitotic checkpoint protein BUB3 [OS=Homo sapiens]",55,13,61,13,328,37.1,6.84,138.72,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","BUB3","ENSG00000154473","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Human T-cell leukemia virus 1 infection",2014.3,2239.8,2167.6,2190.7,2426.3,2438,0.9102338766832037,-0.1356908139939514,0.11335315717395972,0.9455663791622188,0.2601591567355313,0.5847608837801336,3402]
["High","O43687-1","A-kinase anchor protein 7 isoforms alpha and beta [OS=Homo sapiens]",12,1,1,1,104,11.5,4.94,2.61,"transport;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","AKAP7","ENSG00000118507; ENSGGOG00000008778; ENSPPAG00000039914; ENSPTRG00000018599","G protein signaling pathways","","",62,60.1,49.9,59.4,64.4,51.7,0.98005698005698,-0.029062465602462773,0.8355956833851401,0.07800381221357723,0.9057796884452552,0.04297742233163163,7203]
["High","O43688","Phospholipid phosphatase 2 [OS=Homo sapiens]",7,2,6,2,288,32.6,8.35,5.2,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","PLPP2","ENSG00000141934","Triacylglyceride synthesis","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",350.2,349.1,361.7,377.2,370.8,404.1,0.9209270028643348,-0.11884128903688246,0.050411137062440894,1.297473506601239,0.1540548564319133,0.8123246064133351,2555]
["High","O43707","Alpha-actinin-4 [OS=Homo sapiens]",70,61,472,40,911,104.8,5.44,1101.64,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","ACTN4","ENSG00000130402; ENSG00000282844","Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome","Platelet degranulation ; Nephrin family interactions","Focal adhesion; Adherens junction; Tight junction; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Amoebiasis; Viral carcinogenesis; Systemic lupus erythematosus",19409.5,19028.2,19244.4,19050.5,18446.7,18438.8,1.0312160326086957,0.044346598976331884,0.06517328691441303,1.185930375478317,0.18161064390711526,0.7408587017694375,2802]
["Low","O43708","maleylacetoacetate isomerase [OS=Homo sapiens]",5,1,1,1,216,24.2,8.54,0,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","GSTZ1","ENSG00000100577","Metapathway biotransformation Phase I and II","Regulation of pyruvate dehydrogenase (PDH) complex; Glutathione conjugation; Tyrosine catabolism","Tyrosine metabolism; Metabolic pathways",14.6,12.7,12.7,18,15.7,13.5,0.847457627118644,-0.23878685958711665,0.1721395671301172,0.7641192934653844,0.34070107481671863,0.46762649635218817,3945]
["High","O43709-1","Probable 18S rRNA (guanine-N(7))-methyltransferase [OS=Homo sapiens]",16,5,9,5,281,31.9,8.73,28.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","BUD23","ENSG00000071462; ENSGGOG00000001453","7q11.23 copy number variation syndrome","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",528.1,487.5,483.8,503.9,510.6,470.3,1.009832974137931,0.014116691680287887,0.8093950382723843,0.09183946223445578,0.8908593824120069,0.05019084171174434,7094]
["High","O43719","HIV Tat-specific factor 1 [OS=Homo sapiens]",50,32,81,32,755,85.8,4.4,178.62,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","HTATSF1","ENSG00000102241","","","",4103.3,3982.1,3865.6,3608.1,3296.5,3527.1,1.1456426085872866,0.19615705523440308,0.011955536102182963,1.9224309447678132,0.06672539377115409,1.1757088546010055,1399]
["High","O43739","cytohesin-3 [OS=Homo sapiens]",17,4,10,2,400,46.3,5.47,24.52,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","CYTH3","ENSG00000008256","Insulin signaling","Intra-Golgi traffic","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection",209,197.7,181.1,186.2,185.7,192,1.0423834013122892,0.05988601603796106,0.3941056679816833,0.40438731911697123,0.5776566652151274,0.23833021124316545,5327]
["High","O43741","5'-AMP-activated protein kinase subunit beta-2 [OS=Homo sapiens]",22,4,6,4,272,30.3,6.46,9.93,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PRKAB2","ENSG00000131791","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Caloric restriction and aging; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Carnitine metabolism; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy",345.1,331.3,347.5,380.5,382.8,400.6,0.8797147521264713,-0.18489228977838454,0.004529480070872474,2.3439516468415276,0.04074444745780217,1.3899315673593842,868]
["High","O43747-1","AP-1 complex subunit gamma-1 [OS=Homo sapiens]",23,16,55,16,822,91.3,6.8,113.33,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","AP1G1","ENSCANG00000031796; ENSCCAG00000037984; ENSCJAG00000015028; ENSG00000166747; ENSGGOG00000004800; ENSMFAG00000037769; ENSMLEG00000040277; ENSMMUG00000010878; ENSMNEG00000034875; ENSPANG00000016832; ENSPPAG00000031149; ENSPTRG00000008327; ENSRBIG00000018408; ENSRROG00000025423; ENSSBOG00000025975","","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","Lysosome; Human immunodeficiency virus 1 infection",2163.4,2324.6,2191.3,2055.6,2407.8,2208.9,1.0010491134990933,1.5127574540159297E-3,0.9845748446344229,0.006751264415407268,0.99232740246619,0.003345015723495774,7747]
["High","O43752","Syntaxin-6 [OS=Homo sapiens]",31,4,20,4,255,29.2,4.93,32.58,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STX6","ENSG00000135823","","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","SNARE interactions in vesicular transport",196.5,201.1,198.9,203.3,192.4,178.3,1.039198606271777,0.055471401019540324,0.3656637988183305,0.43691803324046113,0.549904264478722,0.2597129123741385,5192]
["High","O43760","Synaptogyrin-2 [OS=Homo sapiens]",32,3,6,3,224,24.8,4.94,14.02,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","SYNGR2","ENSG00000108639","","","",181.8,174,178.8,183.6,176.8,173.7,1.0009361542782254,0.001349953350944026,0.9662523763474686,0.014909424992559275,0.982228688259476,0.007787385444859984,7681]
["High","O43765","Small glutamine-rich tetratricopeptide repeat-containing protein alpha [OS=Homo sapiens]",38,11,72,11,313,34,4.87,137.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","SGTA","ENSG00000104969","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",3585.1,3585,3701.8,3594,3650.2,3444.9,1.0171015333376994,0.024463705086456025,0.4483662704423881,0.34836706581774857,0.6277288577396747,0.20222790565067422,5577]
["High","O43766-1","Lipoyl synthase, mitochondrial [OS=Homo sapiens]",2,1,1,1,372,41.9,8.59,2.72,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","LIAS","ENSG00000121897","","Glyoxylate metabolism and glycine degradation","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors",136,104.5,104.6,87.9,85.8,79,1.365650969529086,0.4495888094907406,0.046581234895405506,1.3317890022515022,0.14718991584918098,0.8321219429949462,2471]
["Medium","O43768","alpha-endosulfine [OS=Homo sapiens]",12,2,2,2,121,13.4,7.24,2.11,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ENSA","ENSG00000143420","","MASTL Facilitates Mitotic Progression","",141.6,130.3,125.2,202.2,114.5,107.3,0.9365566037735847,-0.09456190392609354,0.7860090549718635,0.10457245077781566,0.8759861120782629,0.057502779100853836,7006]
["High","O43776","Asparagine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",42,23,123,23,548,62.9,6.25,267.5,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","NARS1","ENSG00000134440","Photodynamic therapy-induced unfolded protein response","Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",4803.8,5035.5,4840.4,5124,5367,5246.1,0.9328084589918091,-0.1003472234906767,0.024705399290748088,1.607208122613778,0.10025974930465753,0.9988733856569366,1924]
["High","O43791","Speckle-type POZ protein [OS=Homo sapiens]",7,2,2,2,374,42.1,5.8,2.04,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SPOP","ENSG00000121067","mRNA processing; Hedgehog signaling pathway","Hedgehog 'on' state","Hedgehog signaling pathway",27.1,16,17.6,27.7,27,17.9,0.8360881542699725,-0.2582730317400685,0.4450048892496591,0.35163521741798337,0.62492772936355,0.20417020434140548,5560]
["High","O43795","Unconventional myosin-Ib [OS=Homo sapiens]",20,21,52,21,1136,131.9,9.38,118.64,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1B","ENSG00000128641","","","Pathogenic Escherichia coli infection",2425.9,2403.8,2418.8,2328.3,2467.2,2427.8,1.0034887101463321,0.005024385601852872,0.8506754474850691,0.0702361017850004,0.9152644197276312,0.0384534202079071,7257]
["High","O43808","peroxisomal membrane protein PMP34 [OS=Homo sapiens]",3,1,2,1,307,34.5,10.08,5.73,"other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","SLC25A17","ENSG00000100372","","Class I peroxisomal membrane protein import; Alpha-oxidation of phytanate","Peroxisome",91.5,91.7,96.5,89.1,97.2,97.9,0.9841660802251934,-0.023026300766588875,0.6695843584486441,0.17419470005479745,0.795634556500839,0.09928636258667736,6571]
["High","O43809","Cleavage and polyadenylation specificity factor subunit 5 [OS=Homo sapiens]",65,13,76,13,227,26.2,8.82,166.08,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT21","ENSG00000167005","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",3895.9,3963.2,3982.3,3657.9,4132.9,3847,1.017494715496056,0.025021301668493943,0.654386863192677,0.18416542770500383,0.7853447014768555,0.10493968199220319,6506]
["High","O43813","LanC-like protein 1 [OS=Homo sapiens]",22,7,17,7,399,45.3,7.75,32.8,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LANCL1","ENSG00000115365","","","Glutathione metabolism; Metabolic pathways",719.8,741.7,714.8,678.4,721.1,760.4,1.0075929441177833,0.010912924443699103,0.8381064706257106,0.07670080634820371,0.9072418303958892,0.042276933879634396,7213]
["High","O43815","striatin [OS=Homo sapiens]",33,19,37,19,780,86.1,5.27,61.18,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STRN","ENSG00000115808","","PIP3 activates AKT signaling; Extra-nuclear estrogen signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins","",1563,1459.7,1488.7,1679.3,1549.4,1603.6,0.9335926991287794,-0.0991348159456668,0.09271173151624557,1.0328653078144454,0.22792607042784804,0.6422059969108687,3176]
["High","O43818","U3 small nucleolar RNA-interacting protein 2 [OS=Homo sapiens]",28,11,31,11,475,51.8,7.85,70.76,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RRP9","ENSG00000114767","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1524.3,1693.2,1632.3,1594.1,1833.6,1732.1,{"$f":"AVERAGE(T450:V450)/AVERAGE(W450:Y450)","v":0.939920151943874},{"$f":"LOG(Z450,2)","v":-0.0893898926582986},{"$f":"TTEST(T450:V450,W450:Y450,2,2)","v":0.29183146955919825},{"$f":"-LOG10(AB450)","v":0.5348678779018208},{"$f":"AB450*7808/AF450","v":0.4781993944004658},{"$f":"-LOG10(AD450)","v":0.32039097821753065},4765]
["High","O43819","Protein SCO2 homolog, mitochondrial [OS=Homo sapiens]",30,5,9,5,266,29.8,8.85,18.75,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO2","ENSG00000284194","","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Central carbon metabolism in cancer",197.4,170.5,179.4,156.1,173.1,160.3,1.1180796731358529,0.16102299671643086,0.11028179102633469,0.9574961893695112,0.25604526444651243,0.5916832520255114,3363]
["High","O43822","Protein C21orf2 [OS=Homo sapiens]",7,2,2,2,256,28.3,7.34,2.19,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","","CFAP410","ENSG00000160226","Ciliopathies","","",51.2,45.4,60.3,58.4,55.4,41.4,1.0109536082474226,0.015716794780969823,0.9375954909156081,0.02798448993005739,0.9675846673366466,0.014311022228147242,7566]
["High","O43823","A-kinase anchor protein 8 [OS=Homo sapiens]",39,16,37,16,692,76.1,5.15,103.33,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","mitochondrion;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","AKAP8","ENSG00000105127","G protein signaling pathways","","",1308.7,1286.1,1305.7,1584.8,1430.7,1430.2,0.8773646444879323,-0.18875152421479083,0.024914591850160466,1.6035462230293482,0.1008466216516604,0.9963386460145973,1929]
["High","O43824","Putative GTP-binding protein 6 [OS=Homo sapiens]",8,4,6,4,516,56.8,9.42,7.75,"","","","","","","","",228.6,233.4,225.5,183.3,174.6,215.9,1.1981526664342976,0.2608117454180822,0.0413106489894179,1.3839379822127373,0.13690727814489598,0.8635734636691661,2356]
["High","O43829","Zinc finger and BTB domain-containing protein 14 [OS=Homo sapiens]",15,3,3,3,449,50.9,6.04,3.57,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB14","ENSG00000198081","","","",27.1,21,24.2,21.6,26.1,26.2,0.9783491204330174,-0.03157871719503348,0.8297991390537868,0.08102702010283223,0.9032582849201125,0.044188046279634054,7173]
["High","O43837-1","isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [OS=Homo sapiens]",17,5,13,5,385,42.2,8.46,27.69,"other metabolic processes","mitochondrion","other molecular function","IDH3B","ENSG00000101365","TCA cycle (aka Krebs or citric acid cycle)","Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids",345,307.4,319.2,324.4,294.1,319.8,1.035489715442822,0.050313224680277366,0.48845356919630134,0.3111767126006817,0.6608638829119253,0.17988798225070904,5771]
["High","O43847-1","Nardilysin [OS=Homo sapiens]",36,39,93,39,1150,131.5,5,209.19,"","","","","","","","",3907.4,4155.7,4029.4,3793.3,3967,3930.7,1.0343426567445044,0.04871420044303169,0.20744100563249251,0.6831053908608429,0.3845440104412397,0.4150539487156564,4212]
["High","O43852","Calumenin [OS=Homo sapiens]",73,26,176,7,315,37.1,4.64,391.11,"","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","CALU","ENSG00000128595","NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling pathway","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",7619.6,7319.3,8078.6,10551.8,8076.1,7597.3,0.877686347482574,-0.18822262867576642,0.3196469591894596,0.4953294226661239,0.5064536236508321,0.2954603171638575,4928]
["High","O43852-4","Isoform 4 of Calumenin [OS=Homo sapiens]",63,21,133,2,323,38.1,4.58,265.73,"","","","CALU","","","","",323.2,329.5,378.5,547.2,412.9,369.4,0.7756299360661904,-0.366559608383379,0.1520854644676232,0.8179122915562103,0.31323748524484357,0.5041262713240094,3791]
["High","O43861-1","Probable phospholipid-transporting ATPase IIB [OS=Homo sapiens]",2,2,2,2,1147,129.2,7.61,2.23,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP9B","ENSG00000166377","","Ion transport by P-type ATPases","",107.8,89.2,100.5,96,92.7,93.8,1.0530973451327434,0.07463880089275592,0.4144810450609525,0.3824953257015549,0.5959977900250308,0.2247553506317664,5430]
["High","O43865","S-adenosylhomocysteine hydrolase-like protein 1 [OS=Homo sapiens]",45,23,64,12,530,58.9,6.89,117.82,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","AHCYL1","ENSG00000168710","Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways","Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation","Cysteine and methionine metabolism; Metabolic pathways",2090.4,2121.5,2103.9,1993.9,2040.8,2104.2,1.0288162374366743,0.04098531749516423,0.15039812409652156,0.8227575806300818,0.31115753920128253,0.5070196718003589,3774]
["High","O43896","Kinesin-like protein KIF1C [OS=Homo sapiens]",8,8,13,3,1103,122.9,6.9,28.39,"transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1C","ENSG00000129250","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",79.5,78.6,78.3,81.3,81.6,97.8,0.9067894131185271,-0.1411605473580238,0.21226835191243468,0.6731147520156512,0.38979099052970134,0.40916820320827485,4252]
["High","O43909","exostosin-like 3 [OS=Homo sapiens]",9,8,9,8,919,104.7,6.51,23.42,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","EXTL3","ENSG00000012232","Proteoglycan biosynthesis","XBP1(S) activates chaperone genes","Glycosaminoglycan biosynthesis; Metabolic pathways",497.5,535.2,505,497.7,551.4,500,0.9926408882576981,-0.010656212414660754,0.8650569668598358,0.0629552918666981,0.9227274313171583,0.03492656826645451,7320]
["High","O43913","Origin recognition complex subunit 5 [OS=Homo sapiens]",12,7,17,7,435,50.3,7.74,26.53,"DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC5","ENSG00000164815","Cell cycle; G1 to S cell cycle control; DNA replication","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle",1375.6,1278.3,1207.7,1236.4,1337.1,1322,0.9912976511359259,-0.012609782842323652,0.8547704809288188,0.06815048439178661,0.9172688173573691,0.037503370124597146,7276]
["High","O43924","Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [OS=Homo sapiens]",29,3,5,3,150,17.4,5.67,9.61,"other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PDE6D","ENSG00000156973","Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies","ARL13B-mediated ciliary trafficking of INPP5E; RAS processing","Purine metabolism; Metabolic pathways",155.2,181.8,179.9,132.5,183.4,157.9,1.0909666525960322,0.12560700370587327,0.445863619232822,0.35079796297450966,0.6255710941545146,0.20372332698660137,5565]
["High","O43929","origin recognition complex subunit 4 [OS=Homo sapiens]",22,8,13,8,436,50.3,8,29.82,"DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC4","ENSG00000115947","Cell cycle; G1 to S cell cycle control; DNA replication","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle",501.9,554.3,484.6,508.4,598.9,555.5,0.9266297810921336,-0.10993504478091343,0.29149190910385203,0.5353734953828975,0.4780442819329714,0.3205318721987727,4761]
["High","O43933","Peroxisome biogenesis factor 1 [OS=Homo sapiens]",7,10,13,10,1283,142.8,6.33,32.41,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","PEX1","ENSG00000127980","","Peroxisomal protein import","Peroxisome",601.4,586.9,617.4,566.5,598.5,566,1.0431542461005199,0.06095249786848364,0.14768076944687722,0.8306760535495936,0.30790158820860275,0.5115880709264434,3745]
["High","O60216","Double-strand-break repair protein rad21 homolog [OS=Homo sapiens]",50,23,72,23,631,71.6,4.65,170.12,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RAD21","ENSG00000164754","Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin","Cell cycle",1636.6,1664.4,1692,1829.1,1786.6,1720.3,0.9357196401799099,-0.09585175985449258,0.03217040981658134,1.4925434066160215,0.11677664335093775,0.9326440123448486,2151]
["High","O60231","Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [OS=Homo sapiens]",23,22,50,22,1041,119.2,6.8,112.69,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DHX16","ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",1981.6,1875,1915.3,2100.8,1996.7,2018.3,0.9437685993655776,-0.08349492329942541,0.06122889364199,1.2130435878534997,0.17397205296821613,0.7595205115823772,2748]
["High","O60232","Sjoegren syndrome/scleroderma autoantigen 1 [OS=Homo sapiens]",19,2,2,2,199,21.5,5.24,7.53,"cell cycle OR cell proliferation;other biological processes","","","ZNRD2","ENSG00000173465","","","",100.7,94.3,115.1,109.5,73.5,69,1.2305555555555556,0.2993097922253437,0.2447505112550368,0.6112763923337748,0.4279023716702479,0.3686553064105586,4466]
["High","O60244","Mediator of RNA polymerase II transcription subunit 14 [OS=Homo sapiens]",5,6,8,6,1454,160.5,8.73,11.51,"other biological processes","nucleus","other molecular function","MED14","ENSG00000180182","Vitamin D in inflammatory diseases","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",280.4,279.6,266.6,279.2,301.5,308.1,0.93001800180018,-0.10466945301455181,0.10236107911757013,0.9898651443134211,0.24404131473282062,0.6125366439825876,3275]
["High","O60256-1","Phosphoribosyl pyrophosphate synthase-associated protein 2 [OS=Homo sapiens]",37,11,32,10,369,40.9,7.44,86.18,"other metabolic processes;other biological processes","other cell component","enzyme regulator activity;other molecular function","PRPSAP2","ENSG00000141127","","","",916.3,957.8,912.9,933.7,1001.1,895.3,0.9847708561534927,-0.022140028338127553,0.6953870627273453,0.15777339337434473,0.8150078333496116,0.0888382170708673,6662]
["High","O60264","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 [OS=Homo sapiens]",51,55,207,40,1052,121.8,8.09,440.83,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCA5","ENSG00000153147","","Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression","",9108.7,9092,9165.1,9522.2,9921.9,9937.6,0.9313892661078156,-0.10254383912192472,0.008163699588315193,2.0881129850360107,0.054480484090226516,1.2637590421235372,1170]
["High","O60268-1","Uncharacterized protein KIAA0513 [OS=Homo sapiens]",6,2,2,2,411,46.6,5.06,5.53,"","other cell component","","KIAA0513","ENSG00000135709","","","",132.2,157.1,139.6,142.8,130.2,152.6,1.0077537593984962,0.01114316513436663,0.9162497852103564,0.037986114159239026,0.9540043102977014,0.020449663100644663,7499]
["High","O60271-2","Isoform 2 of C-Jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",27,31,84,27,1311,145,5.19,198.73,"","","","SPAG9","","","","",4811.2,4224.9,4101.7,3546.6,3551.8,3381.1,1.2536666825707332,0.32615382395915127,0.01722074377314954,1.7639480950659352,0.08158954331356287,1.088365497768397,1648]
["High","O60281-1","zinc finger protein 292 [OS=Homo sapiens]",7,12,13,12,2723,304.6,7.39,11.68,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF292","ENSG00000188994","","","",195.1,187.3,203.5,204.6,200.9,200.2,0.9673105497771173,-0.04794896144468174,0.24703957724717726,0.6072334645413107,0.43007469769140694,0.36645610726278616,4485]
["High","O60282-1","kinesin heavy chain isoform 5C [OS=Homo sapiens]",46,39,132,24,957,109.4,6.19,281.38,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF5C","ENSG00000168280; ENSPPAG00000031052; ENSPTRG00000012521","Alzheimer's disease and miRNA effects; Alzheimer's disease","Insulin processing","Endocytosis; Dopaminergic synapse; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Salmonella infection; Non-small cell lung cancer",3747.2,3454.6,3637.1,3605.2,3293.6,3436.1,1.0487667998722774,0.06869392093761141,0.24712854307246412,0.6070770911702705,0.43003781241582345,0.36649335604470934,4487]
["High","O60287","nucleolar pre-ribosomal-associated protein 1 [OS=Homo sapiens]",15,23,35,23,2271,254.2,6.47,67.46,"RNA metabolism OR transcription;other metabolic processes","nucleus","","URB1","ENSG00000142207","","","",1031,1067.1,1035.7,944,960.7,974.5,1.0884273409280358,0.12224510216868628,0.004101670251688348,2.3870392570901577,0.03877220499416782,1.4114794997519045,826]
["Low","O60290-1","Zinc finger protein 862 [OS=Homo sapiens]",1,1,2,1,1169,131.6,7.23,0,"other biological processes","nucleus","other molecular function","ZNF862","ENSG00000106479","","","",23.9,13.6,14.9,12.9,11.6,16.5,1.278048780487805,0.3539429020320043,0.34528090282942336,0.46182744141642557,0.5315365318005003,0.27446688163146643,5072]
["High","O60291-1","E3 ubiquitin-protein ligase MGRN1 [OS=Homo sapiens]",22,7,9,7,552,60.7,5.15,21.71,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGRN1","ENSG00000102858","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis; Hedgehog signaling pathway",170.1,175.6,197.8,166.8,210.7,213.2,0.9200948027763669,-0.12014557670803853,0.4141468947206679,0.38284559063907614,0.5957367269673867,0.22494562496814022,5428]
["High","O60293","Zinc finger C3H1 domain-containing protein [OS=Homo sapiens]",11,16,21,16,1989,226.2,8.13,32.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","ZFC3H1","ENSG00000133858","","","",478.5,524.6,501.5,687.2,655.2,659.3,0.7516610880751361,-0.41184577442835163,5.7636852700121476E-4,3.239299742158681,0.017111351554469526,1.7667156859898037,263]
["High","O60294","tRNA wybutosine-synthesizing protein 4 [OS=Homo sapiens]",3,2,3,2,686,75.6,6.73,3.23,"RNA metabolism OR transcription;other metabolic processes","other cell component","other molecular function","LCMT2","ENSG00000168806","","Synthesis of wybutosine at G37 of tRNA(Phe)","",83,89.3,82.9,77.9,90.5,80.4,1.0257234726688105,0.0366418436342671,0.652776299912628,0.18523562172357735,0.7840143592859251,0.10567598310442236,6501]
["High","O60299-1","Leucine zipper putative tumor suppressor 3 [OS=Homo sapiens]",4,2,2,2,673,71.7,7.64,6.26,"other biological processes","cytoskeleton;other cell component","","LZTS3","ENSG00000088899; ENSGGOG00000008647; ENSPTRG00000013192","","","",44.8,41.3,43.5,28,22.7,22.6,1.7680763983628918,0.8221806147508125,7.9833915164376017E-4,3.0978125718113714,0.019120957349799017,1.7184903672206748,326]
["High","O60306","Intron-binding protein aquarius [OS=Homo sapiens]",15,18,39,17,1485,171.2,6.37,84.98,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","AQR","ENSG00000021776","","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","Spliceosome",1513.7,1699.7,1431.7,1522.1,1745.8,1568.6,0.9604259278403805,-0.05825374352454725,0.5746704044700028,0.24058116845936034,0.7252346077423278,0.13952147982072577,6187]
["High","O60307","Microtubule-associated serine/threonine-protein kinase 3 [OS=Homo sapiens]",4,5,9,3,1309,143,8.06,4.49,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","","kinase activity;other molecular function","MAST3","ENSG00000099308","","","",277.4,274,283.5,343.5,317.8,310.8,0.8588622569694477,-0.21950132222158017,0.011416260244164023,1.9424761396379657,0.06549460689671763,1.183794460182665,1361]
["High","O60313-2","Isoform 2 of Dynamin-like 120 kDa protein, mitochondrial [OS=Homo sapiens]",36,30,78,30,997,115.8,7.87,168.46,"","","","OPA1","","","","",3413.2,3572.4,3566.4,3953.8,4293.4,4203.4,0.8475093569787802,-0.23869879838780403,0.00517782861558448,2.2858523286670325,0.04380117641439178,1.3585142250343094,923]
["High","O60318","Germinal-center associated nuclear protein [OS=Homo sapiens]",13,16,20,16,1980,218.3,6.39,57.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3AP","ENSG00000160294","","","",815.5,809,831,831,810.1,877.9,0.9747915839618897,-0.03683429953893148,0.37217075689140994,0.4292577543101248,0.5561548841738045,0.254804244434581,5225]
["High","O60331","Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [OS=Homo sapiens]",6,4,4,4,668,73.2,5.29,9.33,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIP5K1C","ENSG00000186111","B cell receptor signaling pathway; Focal adhesion; Regulation of actin cytoskeleton","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer",230.7,228.5,248.1,185.1,183.5,192.6,1.2603349964362078,0.3338072523453451,0.002016827426060652,2.6953312614877913,0.028947405409341126,1.5383903565273358,544]
["High","O60333","Kinesin-like protein KIF1B [OS=Homo sapiens]",14,21,40,2,1816,204.3,5.6,93.91,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1B","ENSG00000054523","Intracellular trafficking proteins involved in CMT neuropathy","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",524,537.4,575,618.4,614.4,596.1,0.8947454754223851,-0.16045075169380735,0.018558591473239794,1.7314549881717054,0.08533891768142303,1.068852869421004,1698]
["High","O60333-3","Isoform 3 of Kinesin-like protein KIF1B [OS=Homo sapiens]",21,19,33,4,1153,130.3,8.43,68.92,"","","","KIF1B","","","","",225.7,192.5,196.7,263.3,233.3,229.8,0.8465033039647576,-0.24041239581042784,0.0671490283914243,1.1729602669460593,0.18526488115909573,0.732206897811714,2830]
["High","O60337","E3 ubiquitin-protein ligase MARCH6 [OS=Homo sapiens]",2,2,2,2,910,102.5,6.28,2.75,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","MARCHF6","ENSG00000145495","","ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",124.4,127.1,137.6,146.6,134,151.4,0.9006944444444446,-0.15089033207797506,0.09501598073673488,1.0222033445837875,0.23140510841934683,0.6356270579432782,3206]
["High","O60341","Lysine-specific histone demethylase 1A [OS=Homo sapiens]",59,30,92,30,852,92.8,6.52,245.15,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM1A","ENSG00000004487","Androgen receptor signaling pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects","Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Thermogenesis",4877.9,4498.5,4314.2,3322.6,3201.8,3453.3,1.3721198272146886,0.456406477560016,2.4000035864562026E-3,2.6197881092979878,0.030770489331773447,1.511865597272228,609]
["High","O60343-1","TBC1 domain family member 4 [OS=Homo sapiens]",13,14,26,14,1298,146.5,7.01,51.72,"transport;other biological processes","cytosol;other cell component","enzyme regulator activity","TBC1D4","ENSG00000136111","Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane","Thyroid hormone signaling pathway; Insulin resistance; Diabetic cardiomyopathy",710.1,649.7,688.1,691.9,672.4,683.8,0.9999023485181389,-1.4088818769863819E-4,0.9973021262736421,1.1732550317831373E-3,0.9990935337367972,3.9385182981926053E-4,7794]
["High","O60344-1","Endothelin-converting enzyme 2 [OS=Homo sapiens]",5,3,8,3,883,99.7,5.1,11.83,"protein metabolism;other metabolic processes;developmental processes","plasma membrane;other membranes;ER/Golgi","other molecular function","EEF1AKMT4-ECE2","ENSG00000284917","","","",213.9,177.7,184.3,189.7,184.9,179,1.0402817919075147,0.05697437905938616,0.5549892998043995,0.25571538999570526,0.7112024376945267,0.14800676346153904,6093]
["High","O60353-1","Frizzled-6 [OS=Homo sapiens]",7,4,5,4,706,79.2,7.96,6.4,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","FZD6","ENSG00000164930","Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","Class B/2 (Secretin family receptors); Ca2+ pathway; PCP/CE pathway; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",174.4,206.6,179.2,171.1,179.8,189.8,1.036064361013501,0.051113626992506996,0.5988125727728761,0.22270908971081663,0.7443923846856578,0.12819807845625433,6281]
["High","O60427","Fatty acid desaturase 1 [OS=Homo sapiens]",4,2,4,2,444,51.9,8.87,7.33,"cell-cell signaling;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","FADS1","ENSG00000149485","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection","PPARA activates gene expression; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism",356.4,384.7,373.1,405.9,428.4,423.4,0.885902838514749,-0.17477961515839657,0.010988360038445161,1.9590671191688098,0.06421939758995496,1.1923337726497012,1336]
["High","O60437","periplakin [OS=Homo sapiens]",29,51,83,51,1756,204.6,5.6,173.43,"cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PPL","ENSG00000118898","","Formation of the cornified envelope; Butyrophilin (BTN) family interactions","",4405.5,4108.6,4399.4,3553.2,3262.4,3223,1.2863845556153248,0.3633219906788135,2.5776314088151843E-3,2.588779184950924,0.03139804374419494,1.5030974098111058,641]
["High","O60443","Non-syndromic hearing impairment protein 5 [OS=Homo sapiens]",9,4,7,4,496,54.5,5.17,20.01,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","transporter activity;other molecular function","GSDME","ENSG00000105928","","Regulation of TLR by endogenous ligand; Release of apoptotic factors from the mitochondria; Pyroptosis; Defective pyroptosis","",263.3,286,252.7,244.5,300.8,270.2,0.9834457388105456,-0.024082640256964095,0.8244811811166921,0.08381925273074153,0.8997273322374747,0.04588908616790133,7155]
["High","O60447","Ecotropic viral integration site 5 protein homolog [OS=Homo sapiens]",4,3,3,3,810,92.9,6.1,9.69,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","EVI5","ENSG00000067208","","","",244,219.7,238.4,233.7,214.6,196.4,1.0890336590662324,0.12304854452084515,0.21608633844633565,0.6653726895023259,0.39457486683559134,0.4038705813804309,4276]
["High","O60462-1","Neuropilin-2 [OS=Homo sapiens]",3,2,2,2,931,104.8,5.17,3.8,"","","","","","","","",16.5,12.8,15.7,23.5,21.7,17.6,0.7165605095541401,-0.4808395576745901,0.046040075115428326,1.3368639764803558,0.14583403914858595,0.8361410954349693,2465]
["High","O60476","mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [OS=Homo sapiens]",11,5,7,5,641,73,7.61,10.76,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","MAN1A2","ENSG00000198162","","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum",223.4,232.1,208.9,155.9,164.9,170.7,1.3517802644964394,0.4348606567344331,0.001986712487459508,2.7018649784586177,0.029103660604284872,1.5360523828265547,533]
["High","O60481","Zinc finger protein ZIC 3 [OS=Homo sapiens]",5,3,5,2,467,50.5,8.65,8.13,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZIC3","ENSG00000156925","Mesodermal commitment pathway","POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","Signaling pathways regulating pluripotency of stem cells",367.6,388.9,390.3,359.3,358,364.6,1.0599870598021996,0.08404665264399597,0.046857431338679825,1.3292215225255113,0.14782336318885336,0.8302569211364634,2475]
["High","O60488-1","Long-chain-fatty-acid--CoA ligase 4 [OS=Homo sapiens]",30,16,48,13,711,79.1,8.38,113.55,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL4","ENSG00000068366","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway",1893.8,2053.2,1914.9,1842.1,2124.2,2078.5,0.9697425886712546,-0.04432624999103803,0.5775704157031103,0.23839506028942514,0.7273660977112718,0.13824694512904362,6200]
["Medium","O60493-1","sorting nexin-3 [OS=Homo sapiens]",9,1,1,1,162,18.8,8.66,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","LOC111158258; Snx3; SNX3; Snx3_1","ENSAMEG00000008145; ENSANAG00000028701; ENSBIXG00000016466; ENSBIXG00005007963; ENSBMUG00000010256; ENSBTAG00000018801; ENSCANG00000036155; ENSCATG00000029122; ENSCCAG00000022069; ENSCGRG00015001325; ENSCHIG00000003391; ENSCJAG00000005955; ENSCSAG00000015156; ENSDLEG00000017815; ENSFCAG00000024997; ENSG00000112335; ENSLCNG00005012116; ENSMFAG00000039300; ENSMMNG00015010894; ENSMMUG00000020366; ENSMNEG00000027766; ENSMPUG00000009812; ENSMUSG00000019804; ENSNVIG00000004406; ENSOARG00000010805; ENSPANG00000017995; ENSPCOG00000020531; ENSPCTG00005013214; ENSPPAG00000032382; ENSPPYG00000016894; ENSPTRG00000018473; ENSPTRG00000046352; ENSRFEG00010011106; ENSRROG00000037899; ENSSBOG00000028606; ENSSSCG00000004385; ENSSSCG00070023370; ENSSSUG00005019212; ENSSTOG00000007274; ENSTSYG00000035289; ENSTTRG00000008868; ENSUAMG00000027552","","Ub-specific processing proteases; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking","Endocytosis",32.2,27.3,33,38.1,27.7,19.6,1.0831381733021077,0.11521729578318408,0.6964638950202393,0.1571013926641472,0.8156577309611562,0.08849204313107568,6667]
["Medium","O60499","Syntaxin-10 [OS=Homo sapiens]",4,1,1,1,249,28.1,4.89,2.33,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","STX10","ENSG00000104915","","Retrograde transport at the Trans-Golgi-Network","Salmonella infection",51.2,40,56.3,51,50.8,63.1,0.8944815039417828,-0.16087644430090126,0.40947699803975185,0.3877704892759243,0.5911975592999968,0.2282673675508683,5408]
["High","O60502","protein O-GlcNAcase [OS=Homo sapiens]",30,25,64,25,916,102.8,4.91,110.82,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","OGA","ENSG00000198408","","","Insulin resistance",2563.3,2627.2,2499.1,2684.2,2717.5,2570.9,0.964503424227981,-0.05214173467627262,0.17776530454825681,0.7501529987853822,0.3481292946859265,0.45825942978914136,3987]
["High","O60504-1","Vinexin [OS=Homo sapiens]",10,5,5,5,671,75.3,9.45,8.12,"cell adhesion;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","SORBS3","ENSG00000120896","","Smooth Muscle Contraction","",139.8,133.6,136.6,144.8,147.3,165.1,0.8967629046369203,-0.15720149382166995,0.07677053572577669,1.1148054287570073,0.2024398321333551,0.693704031487671,2961]
["High","O60506","Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",57,31,235,2,623,69.6,8.59,555.55,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","SYNCRIP","ENSG00000135316","","","",8632.4,8799.4,8970.1,9705.2,9694.4,9750,0.905737986113017,-0.14283433027296918,0.000757829252902054,3.120428634573379,0.018844365626303303,1.724818477987959,314]
["High","O60506-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",55,29,216,1,562,62.6,7.56,498.21,"","","","SYNCRIP","","","","",116.5,94.2,107.6,124.2,127.7,113.8,0.870385561936013,-0.20027346970544746,0.10974172516953748,0.9596282168598103,0.2553228218485544,0.5929103643578375,3356]
["High","O60507","Protein-tyrosine sulfotransferase 1 [OS=Homo sapiens]",5,2,2,2,370,42.2,9.09,2.99,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","TPST1","ENSG00000169902","","Cytosolic sulfonation of small molecules; Gamma carboxylation, hypusine formation and arylsulfatase activation; Defective F8 sulfation at Y1699","",189.6,171.1,153.8,129.4,120.1,125.9,1.3705380927011188,0.4547424269504566,0.012263790155999875,1.9113752892423148,0.06748109481187246,1.1708178800411533,1419]
["High","O60508","pre-mRNA-processing factor 17 [OS=Homo sapiens]",25,12,18,12,579,65.5,7.06,29.06,"RNA metabolism OR transcription;other metabolic processes","nucleus","","CDC40","ENSG00000168438","mRNA processing","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","Spliceosome",830.1,745.7,795.3,741.2,640,684.3,1.1479544904381507,0.19906544887717312,0.05591054050687695,1.2525063092433941,0.16368560190389772,0.7859895202746349,2667]
["High","O60512","beta-1,4-galactosyltransferase 3 [OS=Homo sapiens]",5,2,4,2,393,43.9,9.25,8.84,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi","other molecular function","B4GALT3","ENSG00000158850","","N-Glycan antennae elongation; Keratan sulfate biosynthesis","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways",167.6,156.5,164.8,154.8,167.7,179.2,0.974486745066773,-0.037285532756159395,0.6132765973833814,0.21234360766075253,0.7555165150472455,0.1217560378563988,6338]
["High","O60513","Beta-1,4-galactosyltransferase 4 [OS=Homo sapiens]",6,2,2,2,344,40,9.07,5.73,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B4GALT4","ENSG00000121578","","N-Glycan antennae elongation; Keratan sulfate biosynthesis","Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways",131.7,128.4,113.1,100.9,115.5,106.9,1.154345808846273,0.20707547872567356,0.07988844928181592,1.0975160088687672,0.20785371942433145,0.6822421996349843,3001]
["High","O60518","ran-binding protein 6 [OS=Homo sapiens]",4,4,30,1,1105,124.6,5.01,33.4,"transport","nucleus;other cell component","other molecular function","RANBP6","ENSG00000137040","","","",40.2,38.2,40.3,31.5,34,41,{"$f":"AVERAGE(T514:V514)/AVERAGE(W514:Y514)","v":1.1145539906103288},{"$f":"LOG(Z514,2)","v":0.15646650452870628},{"$f":"TTEST(T514:V514,W514:Y514,2,2)","v":0.23669405997208037},{"$f":"-LOG10(AB514)","v":0.6258126409036915},{"$f":"AB514*7808/AF514","v":0.4175569860510627},{"$f":"-LOG10(AD514)","v":0.3792842458362953},4426]
["High","O60524","nuclear export mediator factor NEMF [OS=Homo sapiens]",16,16,29,16,1076,122.9,6.35,56.39,"protein metabolism;other metabolic processes;transport","nucleus;other cell component","translation activity;nucleic acid binding activity","NEMF","ENSG00000165525","","","",1108.8,1172.2,1173.9,1296.5,1315.3,1244.4,0.8959338208599139,-0.15853592492965865,0.01135419273354111,1.9448437380476358,0.06537871450109808,1.184563622920045,1356]
["High","O60547-1","GDP-mannose 4,6 dehydratase [OS=Homo sapiens]",24,8,14,8,372,41.9,7.31,28.11,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","GMDS","ENSG00000112699; ENSPPAG00000026874; ENSPPYG00000016168; ENSPTRG00000017663","","GDP-fucose biosynthesis","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",958.2,1085.7,1030.8,990.5,1117.4,1050.1,0.973622545915136,-0.03856551834830528,0.621841485964626,0.206320307502707,0.7617411864467838,0.11819256198178543,6374]
["High","O60551","Glycylpeptide N-tetradecanoyltransferase 2 [OS=Homo sapiens]",13,6,24,2,498,56.9,7.58,43.67,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NMT2","ENSG00000152465","","Membrane binding and targetting of GAG proteins; Inactivation, recovery and regulation of the phototransduction cascade","",128.6,114.7,135,116.3,107.7,115.2,1.1152712264150944,0.15739460648617687,0.11841397742903695,0.926597031041971,0.26830421815609995,0.5713724994953453,3446]
["High","O60563","Cyclin-T1 [OS=Homo sapiens]",17,10,15,10,726,80.6,8.78,34.59,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","CCNT1","ENSG00000129315","Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins","Transcriptional misregulation in cancer",1059.3,1078.7,1083.6,1003.2,929,1013.6,1.0936248217801614,0.12911789298414605,0.029245963799405673,1.5339340619099444,0.11020872844872563,0.9577840083245044,2072]
["High","O60566","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta [OS=Homo sapiens]",29,25,53,25,1050,119.5,5.27,104.76,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","BUB1B","ENSG00000156970","Regulation of sister chromatid separation at the metaphase-anaphase transition","Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Human T-cell leukemia virus 1 infection",2493.5,2596.1,2506.5,2305.4,2115.5,2134.9,1.1586839134811924,0.21248705586320965,0.007134749999684111,2.146621239880777,0.05106152887033322,1.2919061858104834,1091]
["High","O60568","Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [OS=Homo sapiens]",29,18,53,18,738,84.7,6.05,89.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi","other molecular function","PLOD3","ENSG00000106397","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway","Collagen biosynthesis and modifying enzymes","Lysine degradation; Other types of O-glycan biosynthesis; Metabolic pathways",1632.3,1641.7,1636.8,1689,1710.3,1655.7,0.9714737883283878,-0.041753024407467754,0.040653203693685434,1.3909052239526924,0.1355917191116172,0.8677668329906815,2341]
["High","O60573","eukaryotic translation initiation factor 4E type 2 [OS=Homo sapiens]",42,10,20,10,245,28.3,8.88,48.7,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF4E2","ENSG00000135930","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance","ISG15 antiviral mechanism","EGFR tyrosine kinase inhibitor resistance; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Longevity regulating pathway; Insulin signaling pathway",1083.7,1142.5,1117.6,1109.4,1113.3,1111.1,1.0029995800587916,0.004321001914973388,0.8547598280707018,0.06815589696326592,0.9173834690826171,0.037449089962575434,7275]
["High","O60583-2","Isoform 2 of Cyclin-T2 [OS=Homo sapiens]",16,9,15,9,663,73.6,9.14,33.54,"","","","CCNT2","","","","",722.7,729.3,687,651.4,596.3,623.7,1.1429945495351075,0.19281852395709856,0.012411981436679393,1.9061588826168547,0.06791363073412242,1.1680430510728663,1427]
["High","O60610-1","Protein diaphanous homolog 1 [OS=Homo sapiens]",38,45,105,44,1272,141.3,5.41,228.5,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH1","ENSG00000131504","Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway","RHOC GTPase cycle; RHOA GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility","Focal adhesion; Regulation of actin cytoskeleton; AGE-RAGE signaling pathway in diabetic complications; Shigellosis",5768.9,5528.5,5530.4,5340.7,5225.3,5411.3,1.0532317725773441,0.07482294857064486,0.04246445307580712,1.3719744650724126,0.13942912094865517,0.8556465106964498,2378]
["High","O60613-1","selenoprotein F [OS=Homo sapiens]",15,2,6,2,162,17.8,5.03,5.79,"","","","","","","","",64.9,56.2,73,59,62.4,58.4,1.0795328142380423,0.11040709719921638,0.3951004305880001,0.4032924970158696,0.5784631843298528,0.23772427604011082,5333]
["High","O60636","tetraspanin-2 [OS=Homo sapiens]",5,1,1,1,221,24.1,7.77,0,"cell organization and biogenesis;stress response;developmental processes","plasma membrane;other membranes;nucleus;other cell component","","TSPAN2","ENSG00000134198","","","",28.1,27.2,28,24.7,18,24.5,1.2395833333333333,0.3098552625867873,0.07289001593064535,1.1373319548531706,0.19577751784880595,0.7082371819649631,2907]
["High","O60637","Tetraspanin-3 [OS=Homo sapiens]",12,4,5,4,253,28,5.81,9.62,"","plasma membrane;other membranes","","TSPAN3","ENSG00000140391","","","",206.4,203.9,204.9,170.1,154.5,174.9,1.2316316316316318,0.30057082528204604,0.003401568239990454,2.4683208120901474,0.03545987292102198,1.4502628251309784,749]
["High","O60645","exocyst complex component 3 [OS=Homo sapiens]",17,12,20,12,756,86.8,6.11,44.52,"","","","","","","","",851.2,858.1,782.4,820.4,829.9,838.2,1.001285915209966,0.001853991713662307,0.9676326007355374,0.014289508147031052,0.9833756796229436,0.007280536676487793,7683]
["High","O60664-1","Perilipin-3 [OS=Homo sapiens]",59,23,111,23,434,47,5.44,261.52,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","PLIN3","ENSG00000105355","","Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle; Lipophagy; Chaperone Mediated Autophagy","",4136.4,4067.3,4147.4,4218.7,3908.9,4018,1.0169197075484127,0.024205773497605835,0.5070755850962879,0.2949272995551035,0.6749482046423143,0.17072955354100147,5866]
["High","O60671-1","Cell cycle checkpoint protein RAD1 [OS=Homo sapiens]",14,2,4,2,282,31.8,4.83,6.33,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD1","ENSCCAG00000029737; ENSG00000113456; ENSGGOG00000004219; ENSMFAG00000012657; ENSMMUG00000045918; ENSPANG00000024799; ENSPPAG00000028406; ENSPPYG00000015389; ENSPTRG00000016783","miRNA regulation of DNA damage response; ATR signaling; DNA damage response","Presynaptic phase of homologous DNA pairing and strand exchange; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","Cellular senescence",48,39.2,59.7,54,56.3,49.3,0.9204260651629074,-0.11962625566606575,0.5374895700830401,0.2696299587599493,0.6984054856396035,0.1558923581145525,6009]
["High","O60674","Tyrosine-protein kinase JAK2 [OS=Homo sapiens]",1,1,2,1,1132,130.6,7.21,2.52,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK2","ENSG00000096968","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Mesodermal commitment pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; IL-6 signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; Overview of interferons-mediated signaling pathway; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 distal deletion syndrome; CCL18 signaling pathway; EPO receptor signaling; Notch signaling pathway; Type II interferon signaling (IFNG); Serotonin receptor 2 and STAT3 signaling","Potential therapeutics for SARS; Signaling by BRAF and RAF1 fusions; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Signaling by SCF-KIT; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Interleukin-4 and Interleukin-13 signaling; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; RMTs methylate histone arginines; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; RAF activation; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; IL-6-type cytokine receptor ligand interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; PI3K-Akt signaling pathway; Necroptosis; Signaling pathways regulating pluripotency of stem cells; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Cholinergic synapse; Prolactin signaling pathway; Adipocytokine signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis B; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",24.3,25.8,22.1,27.6,30.6,25.2,0.8657074340527577,-0.20804854655749272,0.12028528007530817,0.9197875162446145,0.27081530185351965,0.5673268003901518,3468]
["High","O60678","protein arginine N-methyltransferase 3 [OS=Homo sapiens]",18,8,22,8,531,59.8,5.35,43.19,"","","","","","","","",743.8,726.7,690.9,737.2,737.3,734.9,0.9782746446999185,-0.03168854492254535,0.3631821143128329,0.43987554739353524,0.5476488892534955,0.26149778883375296,5178]
["High","O60684","Importin subunit alpha-7 [OS=Homo sapiens]",44,20,107,12,536,60,4.98,265.21,"transport;other biological processes","nucleus;other cell component","other molecular function","KPNA6","ENSG00000025800","","Assembly of the ORC complex at the origin of replication","Nucleocytoplasmic transport; Influenza A; Chemical carcinogenesis",5136.1,5029.5,4896.6,4905,5048.5,4890.7,1.0146858705757131,0.021033162774214634,0.44405469075946163,0.3525635379207017,0.6244918993965916,0.20447319070886485,5552]
["High","O60701","UDP-glucose 6-dehydrogenase [OS=Homo sapiens]",53,21,75,21,494,55,7.12,177.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus","other molecular function","UGDH","ENSG00000109814","Glucuronidation","Formation of the active cofactor, UDP-glucuronate","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",3380.4,3392.6,3324.5,3076.6,3284.9,3283.3,1.0469372096881222,0.06617491887998747,0.10508663444809783,0.9784525166506745,0.2479650775976875,0.6056094791518921,3309]
["High","O60716-1","Catenin delta-1 [OS=Homo sapiens]",46,35,142,35,968,108.1,6.23,291.16,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","CTNND1","ENSG00000198561","VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency","VEGFR2 mediated vascular permeability; Adherens junctions interactions; InlA-mediated entry of Listeria monocytogenes into host cells","Rap1 signaling pathway; Adherens junction; Leukocyte transendothelial migration",5843.3,5681.7,5708.4,6556.4,6110.7,6218.4,0.9125201874453946,-0.1320716192893158,0.018403441978713384,1.7351009436988996,0.0850260798637835,1.0704478436539375,1690]
["High","O60725","protein-s-isoprenylcysteine O-methyltransferase [OS=Homo sapiens]",6,2,3,2,284,31.9,7.96,5.94,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ICMT","ENSG00000116237","Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome","RAS processing; Gamma carboxylation, hypusine formation and arylsulfatase activation","Terpenoid backbone biosynthesis",297.7,326.6,318.1,344.4,350.4,349.8,0.9021635075627035,-0.1485391645417965,0.017873615999445723,1.7477875767757791,0.08351717158807434,1.078224222010535,1671]
["Medium","O60729-1","Dual specificity protein phosphatase CDC14B [OS=Homo sapiens]",2,1,1,1,498,56.8,9.03,1.72,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CDC14B","ENSG00000081377; ENSPPYG00000019417; ENSPTRG00000021155","Cell cycle; Cell cycle","MAPK6/MAPK4 signaling","Cell cycle",54.8,50.9,48.5,82.5,87.8,66.2,0.6520084566596195,-0.6170374183117232,0.015323064539605089,1.81465436919799,0.0761084528786492,1.1185671062427436,1572]
["High","O60749","Sorting nexin-2 [OS=Homo sapiens]",30,15,58,13,519,58.4,5.12,116.69,"cell organization and biogenesis;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX2","ENSG00000205302","","Golgi Associated Vesicle Biogenesis","Endocytosis",2890,2911.1,2789.9,2761.6,2871.4,2864.9,1.0109556478659434,0.015719705443272083,0.579973784215851,0.23659163682966564,0.7288645271458819,0.1373531857841453,6213]
["High","O60762","Dolichol-phosphate mannosyltransferase subunit 1 [OS=Homo sapiens]",30,6,23,6,260,29.6,9.57,40.23,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DPM1","ENSG00000000419","VEGFA-VEGFR2 signaling pathway","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","N-Glycan biosynthesis; Metabolic pathways",877.6,893.8,820.3,879.8,909.8,925.2,0.9546559599233828,-0.06694718827128242,0.18934365497962746,0.7227492437700146,0.3619082639121007,0.4414014999798135,4085]
["High","O60763-1","General vesicular transport factor p115 [OS=Homo sapiens]",42,38,134,38,962,107.8,4.91,304.95,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","USO1","ENSG00000138768","","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization","",5790.7,5647.8,5862.1,6021.5,6021.1,5974.7,0.9602215648293584,-0.05856075822118539,0.021170936149535084,1.6742599376542617,0.0912266387723896,1.0398783263364204,1812]
["High","O60784","Target of Myb protein 1 [OS=Homo sapiens]",25,10,19,10,492,53.8,4.7,26.27,"transport;signal transduction","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","TOM1","ENSG00000100284","","Neutrophil degranulation","",453.2,399.3,411.1,426.8,337.5,362.5,1.121405750798722,0.1653083733719424,0.2179834858641502,0.6615764067152877,0.3966476480138161,0.4015951165893242,4291]
["High","O60825-1","6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",41,17,41,1,505,58.4,8.38,68.77,"other metabolic processes;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PFKFB2","ENSG00000123836; ENSGGOG00000012227; ENSPPAG00000041619; ENSPTRG00000001925","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects","Regulation of glycolysis by fructose 2,6-bisphosphate metabolism","Fructose and mannose metabolism; Metabolic pathways; AMPK signaling pathway; Thyroid hormone signaling pathway",1417.3,1460.2,1349,1165.5,1261,1257.1,1.1473829948962972,0.19834704140426143,0.015806402765793235,1.8011669559199555,0.07766922139415582,1.1097510484686997,1589]
["High","O60825-2","Isoform 2 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",45,17,40,1,471,54.4,7.56,67.1,"","","","PFKFB2","","","","",52.4,60.3,55,48.7,51.2,44.8,1.1589495507947478,0.21281776703262176,0.06171380511738639,1.2096176752589713,0.17484085281442413,0.7573570838359243,2756]
["High","O60826","Coiled-coil domain-containing protein 22 [OS=Homo sapiens]",16,8,11,8,627,70.7,6.74,31.95,"transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","CCDC22","ENSG00000101997","","Neddylation","",512.4,496.3,568.1,599.8,537.1,562.6,0.9278022947925861,-0.10811068038554826,0.22278153360566452,0.6521208107403857,0.4023775652077327,0.3953662416154021,4323]
["High","O60828","Polyglutamine-binding protein 1 [OS=Homo sapiens]",42,9,24,9,265,30.5,6.33,63.4,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PQBP1","ENSG00000102103","","mRNA Splicing - Major Pathway","Spliceosome",909.8,924.6,882,1277.1,982.8,902.9,0.8588592386492981,-0.2195063923281402,0.26345398780371104,0.5792952232895641,0.44776855393369086,0.3489464094899359,4594]
["High","O60830-1","Mitochondrial import inner membrane translocase subunit Tim17-B [OS=Homo sapiens]",33,4,14,4,172,18.3,9.03,34.75,"cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity","TIMM17B","ENSG00000126768; ENSGGOG00000011427; ENSNLEG00000007902; ENSPPAG00000036547; ENSPPYG00000020323; ENSPTRG00000021872","","Mitochondrial protein import","",418.7,439.8,448.4,459.2,464.2,464.2,0.9418420294032864,-0.08644299100257592,0.040106947728051394,1.396780388013466,0.13469034316586034,0.8706635405808033,2325]
["High","O60831","PRA1 family protein 2 [OS=Homo sapiens]",16,3,6,3,178,19.2,9.19,8.51,"transport","other membranes;other cytoplasmic organelle","","PRAF2","ENSG00000243279","","","",503.7,277.7,314.3,287.7,253.4,299.5,1.303473709255294,0.38236148436213774,0.29943787283174544,0.5236932710549903,0.48607295448446325,0.3132985427701867,4810]
["High","O60832-1","H/ACA ribonucleoprotein complex subunit 4 [OS=Homo sapiens]",45,21,88,21,514,57.6,9.42,241.12,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DKC1","ENSG00000130826; ENSGGOG00000001045; ENSPTRG00000022449","","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","Ribosome biogenesis in eukaryotes",3574.9,3881.1,3693,4060.1,4297.8,4232.3,0.88553001540881,-0.17538688633191848,0.01350348816473348,1.8695540318739756,0.07076190308069731,1.1502004956276142,1490]
["High","O60841","Eukaryotic translation initiation factor 5B [OS=Homo sapiens]",39,50,196,49,1220,138.7,5.49,410.84,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","EIF5B","ENSG00000158417","Translation factors; Ciliary landscape","GTP hydrolysis and joining of the 60S ribosomal subunit","",9435.2,9161.2,9059,9088.2,8914,9221.6,1.0158537750056935,0.02269275126718921,0.3723100704690954,0.4290952165616008,0.5562566073904893,0.2547248172942722,5226]
["High","O60858","E3 ubiquitin-protein ligase TRIM13 [OS=Homo sapiens]",15,5,5,5,407,47,6.01,7.74,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","TRIM13","ENSG00000204977","","ER Quality Control Compartment (ERQC)","",74,71.4,74.9,65.2,58.5,61.8,1.187601078167116,0.2480503081927176,0.006205748713924605,2.2072058140508233,0.048357770417488344,1.3155337309234147,1002]
["High","O60870","DNA/RNA-binding protein KIN17 [OS=Homo sapiens]",33,13,23,12,393,45.3,8.95,49.7,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","KIN","ENSG00000151657","","Protein methylation","",915.4,959.5,978.6,1150.4,1039.2,1125.1,0.8608622198087307,-0.21614574077823787,0.016231124951413788,1.7896513789254385,0.07881382065960127,1.1033976186792356,1608]
["High","O60879","Protein diaphanous homolog 2 [OS=Homo sapiens]",11,11,15,11,1101,125.5,6.58,30.96,"cell organization and biogenesis;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH2","ENSG00000147202","","RHOF GTPase cycle","Regulation of actin cytoskeleton",757.1,675.8,715.6,807.1,752.3,750,0.9303282237810685,-0.10418829987069425,0.14818833459986117,0.8291859827150636,0.3086301724608472,0.5105616184779789,3749]
["High","O60884","DnaJ homolog subfamily A member 2 [OS=Homo sapiens]",49,18,78,18,412,45.7,6.48,164.08,"stress response;other biological processes","other membranes;cytosol","other molecular function","DNAJA2","ENSG00000069345","","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","Protein processing in endoplasmic reticulum",3610.9,3570.2,3723.1,3983.3,3820.9,3987.9,0.924703827138508,-0.11293673524650968,0.014353949452123742,1.8430285874824393,0.07301344450956493,1.1365971626370093,1535]
["High","O60885-1","Bromodomain-containing protein 4 [OS=Homo sapiens]",12,13,29,10,1362,152.1,9.19,40.31,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD4","ENSG00000141867; ENSPTRG00000010619","VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome","Potential therapeutics for SARS","",766.9,730.2,793.1,2378.7,2148.6,2261.3,0.33735969124709075,-1.5676404885172195,2.6356622645728853E-5,4.579110241281956,0.004899821657567878,2.3098197270212215,42]
["High","O60888-1","Protein CutA [OS=Homo sapiens]",25,3,30,3,179,19.1,5.5,46.54,"other biological processes","other membranes","other molecular function","CUTA","ENSG00000112514; ENSG00000226492","","","",726.8,689.3,742,643.8,637.9,642.1,1.1217902068822125,0.1658028936019944,0.00772770612077708,2.1119494021918994,0.0531611712696277,1.2744054590624054,1135]
["High","O60890","Oligophrenin-1 [OS=Homo sapiens]",3,2,3,2,802,91.6,7.96,6.85,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","OPHN1","ENSG00000079482","","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle","",25.8,34.1,33.4,41.7,38.7,43.4,0.7536348949919225,-0.4080623283625059,0.027324342004406945,1.5634502874677705,0.10572272664539616,0.9758316447100267,2018]
["High","O60906","Sphingomyelin phosphodiesterase 2 [OS=Homo sapiens]",6,2,2,2,423,47.6,6.98,3.61,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SMPD2","ENSG00000135587","TNF-alpha signaling pathway; S1P receptor signal transduction","Glycosphingolipid metabolism; Ceramide signalling; TNFR1-mediated ceramide production","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",46.7,41.2,35.7,35.8,37.6,44.1,1.0519148936170215,0.07301798645201281,0.6423516392516062,0.19222716324115594,0.7762701747835539,0.10998709962268939,6461]
["High","O60907","F-box-like/WD repeat-containing protein TBL1X [OS=Homo sapiens]",10,4,9,1,577,62.5,6.55,17.27,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1X","ENSG00000101849","Ectoderm differentiation; Ectoderm differentiation; Rett syndrome causing genes","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression","Wnt signaling pathway",97.5,88.9,71.6,84.2,81.2,87.1,1.0217821782178218,0.031087677784097063,0.8258080000528631,0.0831209141932321,0.9006717229239776,0.04543347195243071,7159]
["High","O60911","Cathepsin L2 [OS=Homo sapiens]",8,3,8,2,334,37.3,8.76,14.61,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","CTSV","ENSG00000136943","Endochondral ossification; Endochondral ossification with skeletal dysplasias","MHC class II antigen presentation; Assembly of collagen fibrils and other multimeric structures; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; Trafficking and processing of endosomal TLR; Endosomal/Vacuolar pathway; Activation of Matrix Metalloproteinases","Lysosome; Apoptosis",481.9,440.9,444.3,395.5,399.5,444.1,1.1033007828262449,0.1418261533374261,0.10436479297872658,0.9814459840331629,0.2471581145216552,0.6070251265176805,3297]
["High","O60921","checkpoint protein HUS1 [OS=Homo sapiens]",20,4,12,4,280,31.7,6.84,21.23,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","","HUS1","ENSG00000136273","ATR signaling","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","Cellular senescence",306.7,328,314.8,306.5,327.1,332.1,0.983224603914259,-0.024407077161974502,0.6176926326946669,0.20922757852167725,0.7588017740843233,0.11987166239838384,6356]
["Medium","O60925","prefoldin subunit 1 [OS=Homo sapiens]",6,1,1,1,122,14.2,6.81,2.38,"other biological processes","other cell component","other molecular function","PFDN1","ENSG00000113068","Cellular proteostasis","Prefoldin mediated transfer of substrate  to CCT/TriC","",169.6,123.2,174.4,173.8,121.4,110.4,1.1518737672583825,0.2039826218766766,0.4654594044205095,0.33211819052575237,0.6421037154974095,0.1923948170553884,5660]
["High","O60927","Protein phosphatase 1 regulatory subunit 11 [OS=Homo sapiens]",12,1,4,1,126,13.9,7.01,8.42,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R11","ENSG00000204619; ENSG00000206501; ENSG00000227720; ENSG00000233314; ENSG00000234058; ENSG00000236560; ENSG00000237403; ENSG00000237829","","","",111.2,99.8,97,117.9,90.8,106.3,0.9777777777777779,-0.03242147769237734,0.8076310066451695,0.09278701593394328,0.8897958092120056,0.05070964403682443,7087]
["High","O60930","Ribonuclease H1 [OS=Homo sapiens]",12,4,7,4,286,32,9.16,13.39,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","RNASEH1","ENSG00000171865","","","DNA replication",374.4,359.3,363.7,321,318.2,345.7,1.11422479439537,0.15604032517573574,0.018803193175367352,1.7257683921893447,0.08585691948144343,1.0662246979228633,1710]
["High","O60934","Nibrin [OS=Homo sapiens]",9,4,4,4,754,84.9,6.9,2.27,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NBN","ENSG00000104320","miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks","Homologous recombination; Cellular senescence",27.2,41.2,14.8,34.2,13.3,21.3,1.2093023255813953,0.27417496343899417,0.6485609052413848,0.18804923381546254,0.7811142292341096,0.10728545075973091,6483]
["High","O60942-1","mRNA-capping enzyme [OS=Homo sapiens]",19,9,15,9,597,68.5,8.13,31.54,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RNGTT","ENSG00000111880; ENSGGOG00000007863; ENSNLEG00000013064; ENSPPAG00000024828; ENSPTRG00000018413","mRNA processing; Ciliary landscape; mRNA Processing","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA surveillance pathway",667.3,616.4,670.7,574.6,544.2,567.9,1.1587122784134696,0.21252237304140875,0.010832416413037997,1.9652746534587309,0.06378545049245904,1.1952783728688496,1326]
["High","O75027-1","ATP-binding cassette sub-family B member 7, mitochondrial [OS=Homo sapiens]",22,13,31,13,752,82.6,9.33,70,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","ABCB7","ENSG00000131269","","Mitochondrial ABC transporters; Cytosolic iron-sulfur cluster assembly","ABC transporters",1706,1840.9,1866.8,1967.6,2065.8,2069.5,0.887070081436694,-0.1728800082333865,0.0186197928716092,1.7300251544619534,0.08536896226748364,1.068699997765919,1703]
["High","O75037","Kinesin-like protein KIF21B [OS=Homo sapiens]",4,6,6,4,1637,182.5,7.08,15.92,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF21B","ENSG00000116852","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",179.6,198.2,172.7,174.4,188.3,189.4,0.9971019742800218,-4.187037340207758E-3,0.9556675179826462,0.019693174900138975,0.9760434245138654,0.010530859989842515,7645]
["High","O75044","SLIT-ROBO Rho GTPase-activating protein 2 [OS=Homo sapiens]",28,29,63,26,1071,120.8,6.7,132.98,"","","","","","","","",2307,2352.2,2282.9,2382.8,2315.5,2307,0.990978259317945,-0.013074687847180945,0.5393110730100877,0.2681606627865442,0.6999569245450075,0.15492868571149465,6016]
["High","O75052","Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein [OS=Homo sapiens]",18,7,19,6,506,56.1,6.3,27.08,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","NOS1AP","ENSG00000198929","Sudden infant death syndrome (SIDS) susceptibility pathways","","Circadian entrainment",246.5,276.1,281.5,239.4,258.3,227.8,1.1083390764989662,0.1483993156356278,0.13561236109366576,0.86770072263637,0.2926648190766562,0.5336294805015296,3618]
["High","O75054","Immunoglobulin superfamily member 3 [OS=Homo sapiens]",10,10,13,10,1194,135.1,6.07,25.92,"developmental processes","other membranes","","IGSF3","ENSG00000143061","","","",502.6,494.8,498.6,586.8,569.3,551.9,0.8758782201405152,-0.19119779973285378,2.3833452742823653E-3,2.622813037026855,0.03070818465610018,1.5127458565345058,606]
["High","O75063","Glycosaminoglycan xylosylkinase [OS=Homo sapiens]",20,7,19,7,409,46.4,6.87,40.25,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;nucleus","kinase activity;other molecular function","FAM20B","ENSG00000116199","","","",555.4,569.2,586,617.4,629.2,647.6,0.9030725372188786,-0.14708622137503255,0.007998498184346815,2.096991549442966,0.053884619347178545,1.2685351807479266,1159]
["High","O75064","DENN domain-containing protein 4B [OS=Homo sapiens]",1,1,1,1,1496,163.7,7.21,2.83,"other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","DENND4B","ENSG00000198837","","RAB GEFs exchange GTP for GDP on RABs","",20.4,64.9,15.1,14.1,19.9,24.7,1.710391822827939,0.77432686084072,0.4362575330582123,0.36025706080670644,0.6168596193622821,0.2098136584513154,5522]
["High","O75083","WD repeat-containing protein 1 [OS=Homo sapiens]",52,22,173,22,606,66.2,6.65,467.8,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","WDR1","ENSG00000071127","Hypertrophy model","Platelet degranulation","",5670.1,6031,5765.1,5554.3,6032.3,5837.5,1.0024161936628004,3.4816261653766146E-3,0.9402266967677383,0.026767421628612526,0.9691472011039605,0.013610254144319748,7575]
["Medium","O75093-1","Slit homolog 1 protein [OS=Homo sapiens]",1,1,2,1,1534,167.8,6.57,0,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","SLIT1","ENSG00000187122","Spinal cord injury","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO","Axon guidance",42.3,47.3,38.2,34.4,36.8,32.3,1.2347826086956524,0.30425706856030704,0.05085283256155309,1.2936848513628552,0.1549195929147899,0.8098936528884638,2563]
["High","O75096","Low-density lipoprotein receptor-related protein 4 [OS=Homo sapiens]",6,8,12,8,1905,211.9,5.27,18.09,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LRP4","ENSG00000134569","","ECM proteoglycans","",433.1,454.7,423.1,543.6,502.2,488.9,0.8541734540952631,-0.22739903212179904,0.016938558813258925,1.7711235435965191,0.08094018801341842,1.0918357911342802,1634]
["High","O75113","NEDD4-binding protein 1 [OS=Homo sapiens]",27,15,22,15,896,100.3,5.36,44.29,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","N4BP1","ENSG00000102921","","","",519.3,513,491.9,523.6,506.1,496.5,0.9986895557594023,-1.8918112347460331E-3,0.956442198412305,0.01934127097813856,0.9765791402122764,0.010292556508433111,7647]
["High","O75116","Rho-associated protein kinase 2 [OS=Homo sapiens]",32,43,81,39,1388,160.8,6.02,164.08,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","ROCK2","ENSG00000134318","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; G13 signaling pathway","RHOA GTPase cycle; RHOB GTPase cycle; G alpha (12/13) signalling events; RHOC GTPase cycle; Potential therapeutics for SARS; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; Wnt signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis",3669,3394.6,3570.7,3749.1,3528.4,3583.2,0.9791541981640225,-0.030392020136076066,0.5087673011483363,0.2934808088910586,0.6760474961480957,0.1700227913506421,5876]
["High","O75122","CLIP-associating protein 2 [OS=Homo sapiens]",28,29,69,23,1294,141,8.47,123.98,"","","","","","","","",1907.1,1855.1,1668,2058.8,1866.5,1928.3,0.9276684433511001,-0.10831882897793825,0.20022149369730238,0.6984893030151231,0.37561975559551586,0.42525157423209586,4162]
["High","O75127","pentatricopeptide repeat-containing protein 1, mitochondrial [OS=Homo sapiens]",16,10,20,10,700,78.8,8.59,39.44,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity","PTCD1","ENSG00000106246","","","",767.5,760.8,761.3,786.2,737.6,751.2,{"$f":"AVERAGE(T578:V578)/AVERAGE(W578:Y578)","v":1.0064175824175823},{"$f":"LOG(Z578,2)","v":0.009229031865884215},{"$f":"TTEST(T578:V578,W578:Y578,2,2)","v":0.7561876181065372},{"$f":"-LOG10(AB578)","v":0.12137043809756559},{"$f":"AB578*7808/AF578","v":0.8573127518768466},{"$f":"-LOG10(AD578)","v":0.06686071642425032},6887]
["High","O75128","Protein cordon-bleu [OS=Homo sapiens]",5,5,6,5,1261,135.5,7.75,9.69,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity","COBL","ENSG00000106078","","","",239.3,246.5,255.2,310.5,306.5,298.5,0.8093937738940469,-0.30508634349150343,5.5369896194471012E-4,3.2567262906872845,0.016756905018853862,1.7758061919918793,258]
["High","O75129","Astrotactin-2 [OS=Homo sapiens]",3,3,4,3,1339,148.1,5.97,2.75,"cell adhesion;transport;developmental processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","ASTN2","ENSG00000148219","","","",243.6,195,206.6,206.7,186.6,182.5,1.1205279610976036,0.16417864959220846,0.23241355410009587,0.6337385479717703,0.4128976178415355,0.38415762272292564,4395]
["High","O75131","Copine-3 [OS=Homo sapiens]",18,7,16,7,537,60.1,5.85,30.52,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CPNE3","ENSG00000085719","","Neutrophil degranulation; Glycerophospholipid biosynthesis","",545.6,567,517,548.5,553.1,520.2,1.0048094709581945,0.006921967710036885,0.8907175111847894,0.0502600095275968,0.937167811256008,0.028182636457881403,7421]
["High","O75132","Zinc finger BED domain-containing protein 4 [OS=Homo sapiens]",1,1,1,1,1171,130.2,6.83,2.39,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED4","ENSG00000100426","","","",26,22.9,20.2,17.4,14.9,18.5,1.3602362204724407,0.4438572136160925,0.0372105996870336,1.4293333308204192,0.12833054874397454,0.8916699486780177,2264]
["High","O75143-1","Autophagy-related protein 13 [OS=Homo sapiens]",22,7,15,7,517,56.5,5.12,28.19,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","ATG13","ENSG00000175224","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease","Macroautophagy","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",600.2,580.8,534,603.8,576.7,597.3,0.9646754415569805,-0.0518844557349016,0.3809249208292726,0.41916061404265065,0.5645903154584208,0.24826657567376145,5268]
["High","O75145-1","Liprin-alpha-3 [OS=Homo sapiens]",6,9,9,3,1194,133.4,5.68,19.15,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;other cell component","","PPFIA3","ENSG00000177380","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",343.6,325.4,332,382.2,373.2,331.5,0.9209678903302972,-0.1187772374510877,0.15766744137274796,0.8022579800510922,0.32151146049579943,0.4928035417401444,3829]
["High","O75146","Huntingtin-interacting protein 1-related protein [OS=Homo sapiens]",20,19,30,18,1068,119.3,6.67,74.35,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","cytoskeletal activity;other molecular function","HIP1R","ENSG00000130787","","Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",1071.3,1067.1,1054.8,1139.8,1135.1,1112.6,0.9426420664206642,-0.08521803027258242,2.6607659177572797E-3,2.5749933310472644,0.03152543290720613,1.501338940982639,659]
["High","O75147","Obscurin-like protein 1 [OS=Homo sapiens]",9,12,17,12,1896,206.8,5.63,32.06,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","OBSL1","ENSG00000124006","","Neddylation","",565.6,584.8,575.5,785.7,812.1,839.9,0.7080034458711081,-0.49817171292787304,1.3921369792288079E-4,3.8563180302452937,0.01006463475353568,1.9972019810736081,108]
["High","O75150","E3 ubiquitin-protein ligase BRE1B [OS=Homo sapiens]",39,39,91,37,1001,113.6,6.23,233.37,"protein metabolism;other metabolic processes","nucleus","other molecular function","RNF40","","","","",4017.7,3810.1,3795,3661.4,3758,3668.7,1.0482228695628648,0.06794549037639724,0.0850612744936385,1.0702681144340371,0.21654986346473082,0.6644420857578871,3067]
["High","O75152","Zinc finger CCCH domain-containing protein 11A [OS=Homo sapiens]",36,27,85,27,810,89.1,8.37,174.52,"other metabolic processes;transport","nucleus","nucleic acid binding activity;other molecular function","ZC3H11A","ENSG00000058673","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",4422.5,4506.5,4531.7,4840.2,4608.1,4605.4,0.9578047062339456,-0.06219657052278854,0.07952250246731721,1.099509961726354,0.20717774416577003,0.6836569000133632,2997]
["High","O75153","Clustered mitochondria protein homolog [OS=Homo sapiens]",31,32,66,32,1309,146.6,6.13,126.38,"cell organization and biogenesis","other cell component","nucleic acid binding activity","CLUH","ENSG00000132361","Translation factors","","",2170.5,2226.4,2194.5,2184.4,2179.1,2222,1.0008959076759547,1.2919429167824012E-3,0.9301641236137554,0.031440415219095304,0.9623322482014314,0.01667496055185798,7547]
["High","O75154","Rab11 family-interacting protein 3 [OS=Homo sapiens]",3,2,2,1,756,82.4,4.51,2.62,"cell cycle OR cell proliferation;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RAB11FIP3","ENSG00000090565; ENSG00000275338","","VxPx cargo-targeting to cilium","Endocytosis",32.3,30.3,32.9,29.9,32.4,27.8,1.0599334073251943,0.08397362710957249,0.30861085016429723,0.5105888090452435,0.4954016278953192,0.30504257065128665,4864]
["High","O75157","TSC22 domain family protein 2 [OS=Homo sapiens]",8,6,17,5,780,79.2,5.02,28.74,"stress response;other biological processes","","","TSC22D2","ENSG00000196428","","","",813.7,807.5,887,765.1,632.9,689.1,1.2017632121125006,0.26515266446553676,0.03805598278394694,1.4195770580575298,0.13009680979731073,0.8857333529727047,2284]
["High","O75164-1","Lysine-specific demethylase 4A [OS=Homo sapiens]",16,13,28,13,1064,120.6,5.85,65.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","KDM4A","ENSG00000066135","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","",1009.2,1121.9,1065,1092.7,1154.5,1174.7,0.9340132674829775,-0.09848505159487755,0.13902787772908937,0.8568981067245074,0.29691730560960883,0.5273644891276658,3656]
["High","O75165","DnaJ homolog subfamily C member 13 [OS=Homo sapiens]",14,25,39,25,2243,254.3,6.74,89.93,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","DNAJC13","ENSG00000138246","","Neutrophil degranulation","",1596.7,1579.3,1473.4,1419.7,1567.1,1480.7,1.0407162842753217,0.05757682074409718,0.35157228062162355,0.45398537377925313,0.5374072762516908,0.2696964577119954,5108]
["High","O75167","Phosphatase and actin regulator 2 [OS=Homo sapiens]",4,2,3,2,634,69.7,8.16,6.72,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","enzyme regulator activity;cytoskeletal activity","PHACTR2","ENSG00000112419","","Platelet degranulation","",144.8,145.3,155.7,149.5,139.1,146.6,1.0243566176470587,0.034718060009412764,0.4952316851388185,0.3051915767489832,0.6658806608513681,0.17660359812367202,5807]
["High","O75170","Serine/threonine-protein phosphatase 6 regulatory subunit 2 [OS=Homo sapiens]",7,4,5,4,966,104.9,4.87,2.06,"other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP6R2","ENSG00000100239","","","",112.7,72.5,81,76,57.9,82.2,1.2318371124479406,0.3008114990523843,0.3059527820682843,0.5143455933533896,0.4930607476551422,0.3070995700815383,4845]
["High","O75175","CCR4-NOT transcription complex subunit 3 [OS=Homo sapiens]",16,9,19,9,753,81.8,6.2,32.73,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","","CNOT3","ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615","","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",853.6,770.6,836.1,909,850.1,873.3,0.9346223978118828,-0.09754448372258995,0.13334481020139122,0.8750238824469846,0.2901773350201958,0.5373365121604037,3588]
["High","O75177","Calcium-responsive transactivator [OS=Homo sapiens]",9,2,2,2,396,43,6.44,2.63,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SS18L1","ENSG00000184402","","","",87,89.8,80.9,96.3,79.9,100.5,0.9313335742681607,-0.10263010675033458,0.40512764335153656,0.3924081222929866,0.5868713616491276,0.23145708282108993,5390]
["High","O75179-1","Ankyrin repeat domain-containing protein 17 [OS=Homo sapiens]",18,36,76,24,2603,274.1,6.52,163.5,"stress response;developmental processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","ANKRD17","ENSG00000132466","","","",2480.4,2377.1,2500.2,2499.4,2503.4,2442,0.9883005587792822,-0.016978238584560223,0.5366596862315887,0.270301027602381,0.6976754628864875,0.1563465508067079,6006]
["High","O75182-2","Isoform 2 of Paired amphipathic helix protein Sin3b [OS=Homo sapiens]",13,10,15,9,1130,129.3,6.98,26.54,"","","","SIN3B","","","","",290,322.3,281.3,314.8,309,297.4,0.9700390794615718,-0.043885225309530894,0.5324121997947097,0.2737520015767405,0.69446616371485,0.1583489094222778,5986]
["High","O75190","DnaJ homolog subfamily B member 6 [OS=Homo sapiens]",36,12,36,11,326,36.1,9.16,88.88,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNAJB6","ENSG00000105993","","Regulation of HSF1-mediated heat shock response","",1587.6,1576.2,1568.1,1579.2,1543.3,1514.1,1.020553854117241,0.029352314676241126,0.18139165546508607,0.7413826956046046,0.352139742881997,0.4532849572066923,4022]
["High","O75191","xylulose kinase [OS=Homo sapiens]",7,3,3,3,536,58.3,5.86,8.4,"other metabolic processes","cytosol","kinase activity;other molecular function","XYLB","ENSG00000093217","","Formation of xylulose-5-phosphate","Pentose and glucuronate interconversions; Metabolic pathways",148.6,170.9,162.9,140.8,159.3,172.7,1.0203045685279186,0.028999871722552122,0.7913833655838414,0.10161308259042505,0.8800913428968287,0.05547225096646455,7021]
["High","O75208-1","Ubiquinone biosynthesis protein COQ9, mitochondrial [OS=Homo sapiens]",9,2,4,2,318,35.5,5.94,15.33,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ9","ENSG00000088682","","Ubiquinol biosynthesis","",90.3,94.1,120.3,112.3,106.3,101.8,0.9509987515605492,-0.07248464772222463,0.6253443122905415,0.20388079584930915,0.7643532232881259,0.11670589865711906,6388]
["High","O75223-1","gamma-glutamylcyclotransferase [OS=Homo sapiens]",59,10,47,10,188,21,5.14,103.14,"cell organization and biogenesis;signal transduction","cytosol","other molecular function","C7orf24; GGCT","ENSG00000006625; ENSGGOG00000024930; ENSPPAG00000031715; ENSPTRG00000019041","Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases","Glutathione synthesis and recycling","Glutathione metabolism; Metabolic pathways",1884.5,1910.9,1956.8,2039.2,2102.4,2148.6,0.9144701281358302,-0.1289920508774755,0.00926029964569521,2.0333749601467392,0.05859353292835348,1.232150315185327,1234]
["High","O75251","NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [OS=Homo sapiens]",14,3,12,3,213,23.5,9.99,24.45,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cell component","transporter activity;other molecular function","NDUFS7","ENSG00000115286","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",412,416.6,404.1,423.7,442.5,449.1,0.9372006386375731,-0.09357015758884732,0.031006741836143503,1.5085438666851207,0.11403704204267945,0.9429540561924841,2123]
["High","O75290-1","Zinc finger protein 780A [OS=Homo sapiens]",3,1,1,1,641,74.5,8.65,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF780A","ENSG00000197782; ENSG00000280568","","","Herpes simplex virus 1 infection",213.3,247.6,268.4,260.7,255.7,282.2,0.9132231404958678,-0.13096067788316285,0.2687725086690758,0.5706151550523851,0.45296260472439975,0.34393765059690495,4633]
["High","O75306-1","NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [OS=Homo sapiens]",29,10,26,10,463,52.5,7.55,62.3,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS2","ENSG00000158864","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",1039.5,984.9,1034,962.7,1052.5,1022.3,1.006880658436214,0.009892696566780771,0.8361996000310719,0.07769004451621873,0.9063085059748207,0.04272394400507909,7204]
["High","O75312","Zinc finger protein ZPR1 [OS=Homo sapiens]",28,12,22,12,459,50.9,4.73,52.98,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ZPR1","ENSG00000109917","","","",1518.7,1505.2,1463,1512.1,1445.2,1462.7,1.0151357466063349,0.02167266126366414,0.4414785575439076,0.3550903851022773,0.6216527641664257,0.20645213092882075,5545]
["High","O75323-1","Protein NipSnap homolog 2 [OS=Homo sapiens]",23,6,14,5,286,33.7,9.36,26.19,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;mitochondrion","","NIPSNAP2","ENSG00000146729","","RHOJ GTPase cycle; RHOH GTPase cycle","",449.3,450.6,465.1,449.4,451.3,436.4,1.0208660533991474,0.029793584360766602,0.24880911032889985,0.6041337216776322,0.43151966535940695,0.36499940768349803,4502]
["High","O75326-1","Semaphorin-7A [OS=Homo sapiens]",11,5,9,5,666,74.8,7.64,24.53,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding","SEMA7A","ENSG00000138623; ENSG00000288455","","Other semaphorin interactions","Axon guidance",233.2,256.9,240.5,191.6,190.9,203.9,1.245907230559345,0.31719665022820626,0.004192391304188008,2.377538188496069,0.03906228079128875,1.4082424024677103,838]
["High","O75330-1","Hyaluronan mediated motility receptor [OS=Homo sapiens]",38,27,58,26,724,84,5.83,119.76,"","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","HMMR","ENSG00000072571","","AURKA Activation by TPX2; Hyaluronan uptake and degradation","ECM-receptor interaction",2958.5,2759.1,2869.8,2147.1,1961.1,2005,1.404730746581169,0.4902936266753318,5.112737209796381E-4,3.2913465290548687,0.016293980462893938,1.7879728087607658,245]
["High","O75340","programmed cell death protein 6 [OS=Homo sapiens]",41,6,10,1,191,21.9,5.4,17.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PDCD6","ENSG00000249915","Epithelial to mesenchymal transition in colorectal cancer","","",193.5,178,186.4,190.9,198.9,180.9,0.9775714035395128,-0.032726011628374616,0.5681309218468509,0.2455515725921419,0.7203582718058155,0.14245145250068578,6158]
["High","O75340-2","Isoform 2 of Programmed cell death protein 6 [OS=Homo sapiens]",40,6,9,1,189,21.7,5.4,15.25,"","","","PDCD6","","","","",525.4,529.1,576.2,531,558,546.5,0.997065117701009,-0.004240365673611422,0.9339057090908579,0.02969696968929062,0.965435691325489,0.015276649727822725,7553]
["High","O75347","Tubulin-specific chaperone A [OS=Homo sapiens]",44,5,7,5,108,12.8,5.29,8.45,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TBCA","ENSG00000171530","VEGFA-VEGFR2 signaling pathway","Post-chaperonin tubulin folding pathway","",283.9,297,267.1,353.2,305.9,257.8,0.92485549132948,-0.11270013274936197,0.4708132679277583,0.32715130685957317,0.646519520925068,0.18941835755536107,5686]
["High","O75351","Vacuolar protein sorting-associated protein 4B [OS=Homo sapiens]",38,14,32,11,444,49.3,7.23,58.84,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS4B","ENSG00000119541","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)","Endocytosis; Necroptosis",1146.7,1189,1146.3,1263.6,1177.3,1179.1,0.9618784530386743,-0.05607349431946628,0.2215838115045259,0.6544619715206327,0.4007705351464763,0.39710421551826497,4317]
["High","O75352","Mannose-P-dolichol utilization defect 1 protein [OS=Homo sapiens]",10,2,10,2,247,26.6,8.94,17.33,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","","MPDU1","ENSG00000129255","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective MPDU1 causes CDG-1f","",268.3,318.3,300.7,256,335.2,293.3,1.0031656302996044,4.5598255754267705E-3,0.9742341894680502,0.011336633502937427,0.985978036470063,0.00613275924346909,7715]
["High","O75362","zinc finger protein 217 [OS=Homo sapiens]",13,11,16,10,1048,115.2,8.48,31,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","ZNF217","ENSG00000171940","","Estrogen-dependent gene expression","",727.7,816.8,793.8,951.2,909.5,899.3,0.8472101449275363,-0.23920822988546894,0.010621486899026684,1.97381468223374,0.06287533715511778,1.2015196731214697,1319]
["High","O75367-1","Core histone macro-H2A.1 [OS=Homo sapiens]",42,14,65,12,372,39.6,9.79,178.74,"cell organization and biogenesis;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","H2afy; H2AFY; LOC100466888; LOC101338325; LOC101381952; LOC101564704; LOC102987354; LOC103079324; LOC103663804; LOC106989149; LOC109250833; LOC110591142; LOC111141291; LOC111182462; LOC112404331; LOC112815157; LOC112861289; LOC112917035; LOC113261754; LOC113928700; LOC115516119; LOC116529369; MACROH2A1","ENSAMEG00000017887; ENSCAFG00000001076; ENSCANG00000022762; ENSCJAG00000005818; ENSFCAG00000013924; ENSG00000113648; ENSGGOG00000001707; ENSLCNG00005003680; ENSMLEG00000037795; ENSMNEG00000031666; ENSMPUG00000010011; ENSPCOG00000013464; ENSPCTG00005011747; ENSPPAG00000029258; ENSPTRG00000017256; ENSRBIG00000034425; ENSRROG00000045755; ENSSBOG00000034640; ENSSSUG00005001976; ENSVVUG00000017487","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma","","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus",4103.7,4083.9,4168.4,4091.9,4382.4,4364.6,0.9623877434982748,-0.05530982571798457,0.17377763907371244,0.7600061073561019,0.3429001278462337,0.46483235296349423,3957]
["High","O75368","SH3 domain-binding glutamic acid-rich-like protein [OS=Homo sapiens]",89,8,27,8,114,12.8,5.25,54.5,"","nucleus;other cell component","other molecular function","SH3BGRL","ENSG00000131171","","","",1050.2,999,1104.8,1126.6,918.7,945.1,1.0547084002140181,0.07684418593271447,0.49172473552079016,0.30827794458763297,0.6633356487467743,0.1782666623759974,5788]
["High","O75369-1","Filamin-B [OS=Homo sapiens]",69,132,616,1,2602,278,5.73,1319.52,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLNB","ENSG00000136068","Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host","ISG15 antiviral mechanism","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer",17.4,15.4,17.4,18.2,9.1,15.3,1.1784037558685447,0.23683393372493391,0.411465588141628,0.3856664800267387,0.5931911580889644,0.2268053310451912,5416]
["High","O75369-8","Isoform 8 of Filamin-B [OS=Homo sapiens]",68,132,613,1,2633,281.5,5.71,1316.89,"","","","FLNB","","","","",20423.4,19634.3,20330.3,20466.8,19360.4,20101.6,1.007662426078947,0.011012406903663573,0.7277089572120633,0.1380422794088613,0.8364421519081099,0.07756408934095287,6793]
["High","O75376-1","Nuclear receptor corepressor 1 [OS=Homo sapiens]",5,12,14,11,2440,270,7.11,29.93,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NCOR1","ENSG00000141027","Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome causing genes; 22q11.2 copy number variation syndrome; Notch signaling pathway","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis","Endocrine resistance; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer",842.5,755.3,789.6,903.2,812,783.3,0.9555333199919952,-0.0656219132083565,0.4488392308396723,0.3479091905384908,0.6278281466134291,0.2021592180324676,5582]
["High","O75379-1","Vesicle-associated membrane protein 4 [OS=Homo sapiens]",33,3,6,3,141,16.4,7.34,9.78,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP4","ENSCATG00000035773; ENSG00000117533; ENSGGOG00000023200; ENSMFAG00000031870; ENSMLEG00000033096; ENSMMUG00000023203; ENSMNEG00000025169; ENSNLEG00000015204; ENSPANG00000022546; ENSPPAG00000028975; ENSPTRG00000001680; ENSRBIG00000031656; ENSRROG00000036404","","Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network","SNARE interactions in vesicular transport",110.7,108.6,126.3,156.9,107.5,137.8,0.8592739930382894,-0.21880986414188328,0.2884893450323499,0.5398702222971841,0.47501577520299204,0.32329196728071796,4742]
["High","O75380","NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [OS=Homo sapiens]",39,3,4,3,124,13.7,8.28,14.64,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS6","ENSG00000145494","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",156.3,170.3,163.3,206,177.3,186.3,0.8600772471910113,-0.21746185468354653,0.04736742214550779,1.3245202500291655,0.1490108106817586,0.8267822225332411,2482]
["High","O75381-1","Peroxisomal membrane protein PEX14 [OS=Homo sapiens]",24,8,20,8,377,41.2,4.94,58.29,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PEX14","ENSG00000142655; ENSMFAG00000032533; ENSMMUG00000019979; ENSPANG00000017539; ENSPPAG00000038193; ENSPTRG00000000132","","Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Class I peroxisomal membrane protein import","Peroxisome",1233.2,1205.7,1231.8,1270.8,1236.6,1210,0.987437456286652,-0.018238723280012394,0.4744413369802155,0.32381747891802054,0.6493318070362003,0.18753332301361858,5705]
["High","O75382-1","Tripartite motif-containing protein 3 [OS=Homo sapiens]",4,3,6,1,744,80.8,7.83,14.47,"protein metabolism;other metabolic processes;transport;developmental processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TRIM3","ENSG00000110171; ENSPTRG00000003290","","Interferon gamma signaling","",193.4,90.1,70.2,62.9,52.6,60.4,2.0108015918135305,1.0077707362289579,0.19676667812025012,0.7060484462186374,0.3714589513449983,0.43008917164588806,4136]
["High","O75385","Serine/threonine-protein kinase ULK1 [OS=Homo sapiens]",3,2,2,2,1050,112.6,8.79,3.78,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","ULK1","ENSG00000177169","Target of rapamycin (TOR) signaling; Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; p53 transcriptional gene network; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease","RAB GEFs exchange GTP for GDP on RABs; Macroautophagy; TBC/RABGAPs; Receptor Mediated Mitophagy","Mitophagy; Autophagy; mTOR signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",25.8,21.7,17.9,15.5,22.2,19.5,1.1433566433566433,0.1932754887196931,0.41356669715839295,0.3834544404717999,0.5952311099378308,0.22531437833373164,5425]
["Medium","O75386","Tubby-related protein 3 [OS=Homo sapiens]",2,1,2,1,442,49.6,7.74,3.95,"developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TULP3","ENSG00000078246","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Genes related to primary cilium development (based on CRISPR)","Hedgehog 'off' state","",116.8,114.9,136.5,152.7,141.8,143.6,0.8404473864414518,-0.2507705879730441,0.03871200390179839,1.4121543471267153,0.1317051531438962,0.8803972323413601,2295]
["High","O75390","citrate synthase, mitochondrial [OS=Homo sapiens]",39,16,87,16,466,51.7,8.32,160.5,"other metabolic processes","mitochondrion","other molecular function","CS","ENSG00000062485","TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)","Mitochondrial protein import; Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids",5973.5,5670.8,5609.4,4728.7,4911.8,5064.5,1.173321999319959,0.23059899211539583,0.004632962455247811,2.334141219232366,0.04120065017149762,1.385095930479833,878]
["High","O75391","Sperm-associated antigen 7 [OS=Homo sapiens]",20,3,4,3,227,26,7.91,9.82,"","nucleus","nucleic acid binding activity","SPAG7","ENSG00000091640","","","",88.9,67.5,88.1,102.5,73.7,72.7,0.982322217758136,-0.0257317651414394,0.908782426575047,0.041540079647224906,0.9495213684862797,0.022495257244758416,7473]
["High","O75396","Vesicle-trafficking protein SEC22b [OS=Homo sapiens]",38,8,52,8,215,24.6,6.92,131.89,"","","","","","","","",1338.1,1372.5,1314.8,1394.1,1381.6,1388.4,0.9666914819528828,-0.04887256555248293,0.0542762418617436,1.2653902309314438,0.16070872068884873,0.7939605560662426,2637]
["High","O75400","pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",34,34,103,1,957,108.7,7.56,201.48,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","PRPF40A","ENSG00000196504","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",172.4,171.8,159,187.9,188.6,185.7,0.8950551405193882,-0.15995153150105376,0.01157406255417075,1.936514174740939,0.06591559476510957,1.1810118248718162,1371]
["High","O75400-3","Isoform 3 of Pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",34,34,102,1,939,106.8,7.43,195.17,"","","","PRPF40A","","","","",5013.8,4914.9,5088.7,5290.3,4792.3,5087.8,0.9899145704793545,-0.014624068749463101,0.7557798122150894,0.12160471279037496,0.8569748437083093,0.06703192650039427,6886]
["High","O75410-1","Transforming acidic coiled-coil-containing protein 1 [OS=Homo sapiens]",27,16,31,13,805,87.7,4.88,72.42,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TACC1","ENSG00000147526","","","",1440.5,1477.1,1482,1393.3,1338.3,1362.2,1.074698324295276,0.10393174156076442,0.007790386156087881,2.108441014560861,0.05335731149713524,1.2728060612386982,1140]
["High","O75414","Nucleoside diphosphate kinase 6 [OS=Homo sapiens]",10,2,4,2,186,21.1,8.32,11.3,"other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","NME6","ENSG00000172113","Pyrimidine metabolism","","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",106.3,119.5,102.7,126.7,112.8,118.1,0.9186241610738255,-0.12245336597362583,0.2109196066482777,0.6758830472715508,0.38877721640928997,0.4102991940483628,4236]
["High","O75420","GRB10-interacting GYF protein 1 [OS=Homo sapiens]",20,17,26,17,1035,114.5,5.39,41.2,"signal transduction","cytosol;other cell component","","GIGYF1","ENSG00000146830","","","",694.6,720.2,676.5,971.6,836.5,850.3,0.7866761962082457,-0.3461581646860224,0.01343389317864338,1.8717981093729055,0.07053923196963519,1.1515692732362244,1487]
["High","O75427","Leucine-rich repeat and calponin homology domain-containing protein 4 [OS=Homo sapiens]",33,15,22,15,683,73.4,8.22,37.93,"developmental processes","nucleus","","LRCH4","ENSG00000077454","","","",372.1,320.6,343.3,308.8,274,280.8,1.1996294580824458,0.2625888545514113,0.034928690180622265,1.4568177000192024,0.12318121631901474,0.909455511903271,2214]
["High","O75431","Metaxin-2 [OS=Homo sapiens]",32,7,28,7,263,29.7,6.29,81.16,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus;other cell component","","MTX2","ENSG00000128654","","Mitochondrial protein import; Cristae formation","",1004.9,949.9,942.9,948.4,965.7,1009.4,0.9911749615187275,-0.012788351465563971,0.7636507397403697,0.11710522321031977,0.8616452277301743,0.0646715130084422,6920]
["High","O75436-1","Vacuolar protein sorting-associated protein 26A [OS=Homo sapiens]",30,9,24,8,327,38.1,6.57,44.85,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26A","ENSANAG00000022406; ENSCATG00000037809; ENSCCAG00000021117; ENSCJAG00000012907; ENSCSAG00000007798; ENSG00000122958; ENSMFAG00000042937; ENSMMUG00000004101; ENSMNEG00000039163; ENSNLEG00000011548; ENSPANG00000022152; ENSPPAG00000041182; ENSPPYG00000002386; ENSPTRG00000002567; ENSRBIG00000023684; ENSRROG00000006745; ENSSBOG00000030031","","WNT ligand biogenesis and trafficking","Endocytosis",602.6,721.7,571.4,550.3,723.1,606.6,1.0083510638297875,0.011998009739874244,0.9427329573852882,0.025611309975567334,0.9703215042531413,0.01308434368370366,7586]
["Medium","O75438","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [OS=Homo sapiens]",19,1,1,1,58,7,8.92,2.39,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB1","ENSG00000183648","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",54.2,51.4,62.1,38.3,44.1,33.3,1.4494382022471908,0.5354938244568562,0.017905874385981648,1.7470044665127369,0.08361786316133056,1.077700934957099,1672]
["High","O75439","mitochondrial-processing peptidase subunit beta [OS=Homo sapiens]",36,14,45,13,489,54.3,6.83,111.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;mitochondrion","other molecular function","PMPCB","ENSG00000105819","","Mitochondrial protein import; Processing of SMDT1","",2012.7,1961.7,2013.9,1894.6,1923.5,1983.9,1.0321096173733195,0.045596203360541585,0.11940125692262854,0.9229911014169633,0.26968036275727036,0.5691506763007347,3457]
["High","O75448","Mediator of RNA polymerase II transcription subunit 24 [OS=Homo sapiens]",20,15,19,15,989,110.2,6.95,36.25,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED24","ENSG00000008838","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",748.3,762.3,721,838.1,795.1,801.8,0.9164681724845997,-0.12584331580899086,0.01980714278113847,1.7031781677668603,0.08777194712549896,1.056644267184254,1762]
["High","O75449-1","Katanin p60 ATPase-containing subunit A1 [OS=Homo sapiens]",31,13,18,12,491,55.9,6.9,33.94,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNA1","ENSG00000186625","","","",492.5,410.3,416.1,458.5,430.5,420.5,{"$f":"AVERAGE(T642:V642)/AVERAGE(W642:Y642)","v":1.0071783123329516},{"$f":"LOG(Z642,2)","v":0.010319122813562474},{"$f":"TTEST(T642:V642,W642:Y642,2,2)","v":0.9186725068969238},{"$f":"-LOG10(AB642)","v":0.036839280556957205},{"$f":"AB642*7808/AF642","v":0.9551258234156034},{"$f":"-LOG10(AD642)","v":0.019939412902490187},7510]
["High","O75461-1","transcription factor E2F6 [OS=Homo sapiens]",15,3,5,3,281,31.8,5.5,8.22,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F6","ENSG00000169016; ENSPPAG00000036538; ENSPTRG00000011661","G1 to S cell cycle control; Cell cycle","Transcriptional Regulation by E2F6; G1/S-Specific Transcription","",85.2,74.4,99.2,98,101.7,96.7,0.873144399460189,-0.19570783031332625,0.16262387684252136,0.788815689863284,0.3281052274900276,0.48398685022356003,3870]
["High","O75475-1","PC4 and SFRS1-interacting protein [OS=Homo sapiens]",65,40,255,39,530,60.1,9.13,511.39,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSIP1","ENSG00000164985; ENSGGOG00000016152; ENSPTRG00000020786","MECP2 and associated Rett syndrome","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection","",13653.1,13375.3,14055.1,15015.9,13547.4,14612.1,0.9515487986214372,-0.07165045023892676,0.22026872405124281,0.6570471639306612,0.39940970677940174,0.3985813847594942,4306]
["High","O75477","erlin-1 [OS=Homo sapiens]",27,10,41,7,346,38.9,7.87,78.23,"","","","","","","","",548.2,520.9,523.8,478.6,504.7,460.3,1.10342200055417,0.14198465101229335,0.03270391876441276,1.485400204654978,0.11810924963577005,0.927716089613634,2162]
["High","O75478","Transcriptional adapter 2-alpha [OS=Homo sapiens]",5,2,3,2,443,51.5,6.89,4.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TADA2A","ENSG00000277104","","HATs acetylate histones","",54.9,56.4,42.7,50,63.1,47,0.961898813241724,-0.056042956933993124,0.7726319751716341,0.1120273226560611,0.8678910174277253,0.0615348065070637,6951]
["High","O75487","Glypican-4 [OS=Homo sapiens]",8,3,5,2,556,62.4,6.68,10.26,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC4","ENSG00000076716","Wnt signaling","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Wnt signaling pathway",117.9,131,131.5,153,165.5,155.7,0.8021931674398988,-0.3179784166214445,0.005913294534502415,2.228170488745959,0.047017315402642416,1.3277421718742732,982]
["High","O75489","NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [OS=Homo sapiens]",54,15,51,15,264,30.2,7.5,109.18,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS3","ENSG00000213619; ENSG00000285387","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","RHOG GTPase cycle; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",2146.7,2088.6,2265.1,2482.4,2378.3,2422.7,0.8924952632012519,-0.16408358263548284,0.012195107235890835,1.9138143764284885,0.06724533707474269,1.1723378251236032,1416]
["High","O75494-1","Serine/arginine-rich splicing factor 10 [OS=Homo sapiens]",31,12,42,9,262,31.3,11.27,92.81,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Srsf10; SRSF10","ENSCATG00000031598; ENSCCAG00000022497; ENSCPOG00000034102; ENSG00000188529; ENSGGOG00000000392; ENSMLEG00000016013; ENSMNEG00000041500; ENSMUSG00000028676; ENSNLEG00000027520; ENSPANG00000021680; ENSPCOG00000022379; ENSPCTG00005007467; ENSPPAG00000032557; ENSPPYG00000001726; ENSPTRG00000044753; ENSRBIG00000028456; ENSRFEG00010001865; ENSRROG00000043248; ENSSBOG00000019550; ENSSSCG00070027414; ENSSTOG00000000956; ENSTSYG00000009439","mRNA processing; mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","Spliceosome",2507.1,2271.1,2471.5,2894.9,2512.4,2743.1,0.8894900863761288,-0.16894956855816246,0.08737171009713732,1.0586291639050176,0.22070472741457398,0.6561883643096872,3091]
["High","O75496","Geminin [OS=Homo sapiens]",13,2,2,2,209,23.6,4.96,2.77,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","GMNN","ENSG00000112312","DNA replication","CDT1 association with the CDC6:ORC:origin complex; Activation of the pre-replicative complex","",172.5,157.1,171.8,261.4,167.4,150.5,0.86552736060763,-0.20834866883786707,0.4977284208979287,0.3030075598050362,0.6685469654861564,0.17486807810278887,5813]
["High","O75503","Ceroid-lipofuscinosis neuronal protein 5 [OS=Homo sapiens]",10,2,2,2,358,41.5,7.4,5.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLN5","ENSG00000102805","","","Lysosome",20.5,18.7,16.2,16.7,20.6,21.1,0.9486301369863015,-0.07608239283082871,0.6207716353658901,0.20706813531543664,0.7611471308003878,0.1185313853864139,6368]
["High","O75506","Heat shock factor-binding protein 1 [OS=Homo sapiens]",42,3,4,3,76,8.5,4.36,11.36,"stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","HSBP1","ENSG00000230989","","HSF1 activation; Attenuation phase","",430.2,288.1,475.4,290,241.7,230.8,1.5655081967213111,0.6466310621899201,0.07242649730812298,1.1401025176508313,0.1950693656370556,0.7098109283471934,2899]
["High","O75509","Tumor necrosis factor receptor superfamily member 21 [OS=Homo sapiens]",4,2,2,2,655,71.8,7.83,4.16,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","","TNFRSF21","ENSG00000146072","Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer","PPARA activates gene expression","Cytokine-cytokine receptor interaction",34.8,43.5,37.7,39.3,31.1,45.6,1,0,1,0,1.0008973208563006,-3.8952675727137241E-4,7801]
["High","O75521","Enoyl-CoA delta isomerase 2, mitochondrial [OS=Homo sapiens]",28,6,15,6,394,43.6,9,42.82,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ECI2","ENSG00000198721","","","Fatty acid degradation; Peroxisome",346.1,361.7,375.1,396.2,378.3,403.7,0.9191139025632321,-0.12168443415598477,0.047876934992139075,1.3198736602415686,0.14970889404029714,0.8247523979342808,2497]
["High","O75525-1","KH domain-containing, RNA-binding, signal transduction-associated protein 3 [OS=Homo sapiens]",10,4,18,2,346,38.8,7.61,29.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHDRBS3","ENSCCAG00000031191; ENSG00000131773; ENSGGOG00000000940; ENSRBIG00000036854; ENSRROG00000044792","","PTK6 Regulates Proteins Involved in RNA Processing","",85.2,93.6,104.4,95.1,93.8,80.3,1.0520059435364044,0.0731428554726807,0.5573425841282584,0.2538777731193315,0.7131646831978763,0.1468101717670844,6102]
["High","O75529-1","TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L [OS=Homo sapiens]",12,4,4,4,589,66.1,5.88,7.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","TAF5L","ENSG00000135801; ENSGGOG00000028544; ENSPPAG00000034307; ENSPTRG00000002091","","HATs acetylate histones","Basal transcription factors",133.3,150.6,143.4,112.8,121.6,117.1,1.2156472261735416,0.28172462772121354,0.010883379791115927,1.9632362152357772,0.06384480045757562,1.194874466051817,1331]
["High","O75530","Polycomb protein EED [OS=Homo sapiens]",20,7,11,7,441,50.2,7.03,18.24,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","EED","ENSG00000074266","Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma","Transcriptional Regulation by E2F6; HCMV Early Events; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis","",518.4,520.3,495.9,551.3,597.6,603.7,0.8756133744151545,-0.19163410398767106,0.016544423634954484,1.7813483579401448,0.07964171377418286,1.0988594031566465,1622]
["High","O75531","Barrier-to-autointegration factor [OS=Homo sapiens]",25,3,5,3,89,10.1,6.09,2.34,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BANF1","ENSG00000175334","Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation","",150.6,128.8,145.9,172,118.7,131.5,1.00734249171009,0.01055427627860757,0.9554313407201498,0.019800516790809117,0.9759298676534446,0.010581390515148927,7644]
["High","O75533-1","splicing factor 3B subunit 1 [OS=Homo sapiens]",49,55,274,55,1304,145.7,7.09,581.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101357717; LOC111145177; Sf3b1; SF3B1","ENSANAG00000021577; ENSCANG00000029415; ENSCATG00000035735; ENSCCAG00000020506; ENSCGRG00001016990; ENSCGRG00015028775; ENSCJAG00000003902; ENSCSAG00000011505; ENSDLEG00000016863; ENSFCAG00000005038; ENSG00000115524; ENSLAFG00000001956; ENSLCNG00005009987; ENSMMNG00015005194; ENSMMUG00000022430; ENSMNEG00000042333; ENSMPUG00000007799; ENSMUSG00000025982; ENSNLEG00000006861; ENSPANG00000013417; ENSPCTG00005000567; ENSPPAG00000035007; ENSRNOG00000013516; ENSRROG00000031308; ENSSBOG00000020080; ENSSSCG00000016075; ENSSSCG00070023758; ENSSSUG00005005995; ENSSTOG00000011034; ENSUMAG00000020945","mRNA processing; mRNA processing; mRNA processing","B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway","Spliceosome",13081.3,13225,13399.3,14551.2,14815.7,14641.3,0.9022318567903254,-0.14842986799433924,2.8389854008707319E-4,3.5468368407737496,0.013116448526626434,1.8821837407287878,169]
["High","O75534","cold shock domain-containing protein E1 [OS=Homo sapiens]",47,39,211,39,798,88.8,6.25,409.73,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity","CSDE1","ENSG00000009307","","","",9410.2,9916.5,9563.7,9453,10213.1,10086.7,0.9710144927536232,-0.042435266320396646,0.36084514583056393,0.44267913255321023,0.5459172444574778,0.2628731869645267,5161]
["Low","O75541","zinc finger protein 821 [OS=Homo sapiens]",2,1,1,1,412,46.8,6.55,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF821","ENSG00000102984","","","",8.6,14.4,8.9,12.4,20,8.6,0.7780487804878049,-0.3620674857405766,0.4743185328754261,0.32392990598635996,0.649277542898199,0.1875696181715337,5704]
["High","O75553-5","Isoform DAB553 of Disabled homolog 1 [OS=Homo sapiens]",17,6,6,6,553,59.6,5.36,7.81,"","","","DAB1","","","","",168.5,193.5,166,177.7,186.1,200.5,0.9356725146198831,-0.09592441999853543,0.33379272662331444,0.47652313087359127,0.5210423049729787,0.2831270136094396,5002]
["High","O75554","WW domain-binding protein 4 [OS=Homo sapiens]",18,5,7,5,376,42.5,5.57,13.15,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","WBP4","ENSG00000120688","","mRNA Splicing - Major Pathway","",324,329.8,336.9,364.8,311.3,339,0.9759629593143532,-0.035101700611038913,0.6357458016153048,0.1967164991684966,0.7710318762057005,0.11292766685945596,6438]
["High","O75569-1","Interferon-inducible double-stranded RNA-dependent protein kinase activator A [OS=Homo sapiens]",30,9,38,9,313,34.4,8.41,73.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function","PRKRA","ENSCATG00000032736; ENSG00000180228; ENSMNEG00000031681; ENSPANG00000001046; ENSPTRG00000012688","VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","",2015.4,1891.4,2016.9,1776.4,1676.3,1689.2,1.1520449639238417,0.20419702577676774,0.007496357738471844,2.1251496963816017,0.05240068148790345,1.2806630648385753,1117]
["High","O75581","Low-density lipoprotein receptor-related protein 6 [OS=Homo sapiens]",11,13,17,13,1613,180.3,5.31,37.04,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","LRP6","ENSG00000070018; ENSG00000281324","MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Type I collagen synthesis in the context of osteogenesis imperfecta; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by WNT ligand antagonists; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","mTOR signaling pathway; Wnt signaling pathway; Parathyroid hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Pathways in cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer",663.6,654.3,656.5,713.9,704,699.9,0.9322882236282934,-0.1011520514714434,6.7614610904807729E-4,3.1699594468144485,0.018331072289747875,1.736812129915044,288]
["High","O75586","Mediator of RNA polymerase II transcription subunit 6 [OS=Homo sapiens]",9,2,3,2,246,28.4,8.62,2.57,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MED6","ENSG00000133997","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway","",92.1,118.6,115.2,102.4,113,114.9,0.9866787768695124,-0.019347617546961137,0.880913513902579,0.05506672754551196,0.9308665200367217,0.031112589445642234,7389]
["High","O75592-1","E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",3,13,16,13,4640,509.8,7.03,32.47,"","","","","","","","",862.7,845.9,859.3,789.2,807.9,761.9,1.0885544722339973,0.12241360307553988,0.00823670004352919,2.0842467494602968,0.05478036962510725,1.261375041713257,1174]
["High","O75600-1","2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [OS=Homo sapiens]",3,1,1,1,419,45.3,8.05,2.88,"other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","GCAT","ENSG00000100116","","Threonine catabolism","Glycine, serine and threonine metabolism; Metabolic pathways",14.9,12.9,13.3,9.4,14.7,14.2,1.0731070496083552,0.10179400175672601,0.6308348233964816,0.2000843407212292,0.7671014329667852,0.1151472059790884,6421]
["High","O75607","Nucleoplasmin-3 [OS=Homo sapiens]",44,5,36,5,178,19.3,4.63,63.14,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NPM3","ENSG00000107833","","","",798.7,664.4,773.6,709.7,694.5,676.2,1.0751297827340895,0.1045108231685898,0.28598990075258385,0.5436493029718877,0.47219478644029916,0.32587881232867866,4729]
["High","O75608","Acyl-protein thioesterase 1 [OS=Homo sapiens]",56,8,40,8,230,24.7,6.77,72.67,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LYPLA1","ENSG00000120992","","RAS processing; eNOS activation","Glycerophospholipid metabolism; Choline metabolism in cancer",1358.9,1366.3,1399.2,1503.3,1509.9,1596.5,0.8947219992624249,-0.1604886053458405,0.007595708738813284,2.1194316968512092,0.05267077605031449,1.2784302827079013,1126]
["High","O75616-1","GTPase Era, mitochondrial [OS=Homo sapiens]",7,2,4,2,437,48.3,8.84,9.83,"cell organization and biogenesis","other membranes;cytosol;mitochondrion","translation activity;nucleic acid binding activity;other molecular function","ERAL1","ENSG00000132591","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",88.7,87.9,87.9,91.6,105.1,91.5,0.9177654406662041,-0.12380261317335926,0.1557419739304241,0.8075943251987626,0.31850008707405747,0.49689044459777515,3818]
["High","O75643-1","U5 small nuclear ribonucleoprotein 200 kDa helicase [OS=Homo sapiens]",49,87,348,87,2136,244.4,6.06,756.77,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","SNRNP200","ENSCATG00000015790; ENSG00000144028; ENSGGOG00000005174; ENSMLEG00000019083; ENSPPAG00000041559; ENSPPYG00000012068; ENSPTRG00000012230; ENSRBIG00000044690; ENSRROG00000037952","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",14640,14493.6,14146.3,13589.5,14386.9,13993,1.0312251306904552,0.04435932734664347,0.18457371235513775,0.7338301526712239,0.35601569813955425,0.44853085184433117,4048]
["High","O75648-1","Mitochondrial tRNA-specific 2-thiouridylase 1 [OS=Homo sapiens]",14,4,4,4,421,47.7,8.03,6.21,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TRMU","ENSG00000100416","","tRNA modification in the mitochondrion","",99.9,90.9,104,106.5,122.2,118.7,0.8485895221646517,-0.23686122961532316,0.045978237526199964,1.3374476804637874,0.14569727216094536,0.8365485792975398,2464]
["High","O75663","TIP41-like protein [OS=Homo sapiens]",31,8,25,8,272,31.4,5.91,37.38,"stress response;signal transduction;other biological processes","cytosol","","TIPRL","ENSG00000143155","Ciliary landscape","","",1228.2,1296.9,1309.2,1283.5,1322.7,1282.1,0.9861121827019522,-0.020176314185340608,0.5619363324591652,0.25031288732774354,0.7165766591280683,0.14473734210484102,6123]
["High","O75665","Oral-facial-digital syndrome 1 protein [OS=Homo sapiens]",9,7,7,7,1012,116.6,6.1,18.72,"cell organization and biogenesis;transport;developmental processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","OFD1","ENSG00000046651","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state","",191.3,154.9,170.3,184.3,192.5,178.4,0.9302953890489912,-0.10423921882583924,0.31783411643747356,0.4977994872881743,0.505016031978794,0.29669483477360103,4914]
["High","O75674","TOM1-like protein 1 [OS=Homo sapiens]",11,4,5,4,476,53,5.24,16.3,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TOM1L1","ENSG00000141198","","","",163.5,146.3,162,169,187.8,190.9,0.8614204856673361,-0.21521046178907483,0.04492654583118082,1.3474969707709792,0.14394192443572418,0.841812695297068,2437]
["High","O75676","Ribosomal protein S6 kinase alpha-4 [OS=Homo sapiens]",3,2,3,2,772,85.6,8.28,4.53,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","RPS6KA4","ENSG00000162302","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Interferon type I signaling pathways","Recycling pathway of L1","MAPK signaling pathway; TNF signaling pathway",57.4,58.6,53.6,86.2,75,77.4,0.71081307627829,-0.4924578731320289,3.488218632589669E-3,2.457396302423084,0.03597887857762237,1.4439523772645215,757]
["High","O75683","Surfeit locus protein 6 [OS=Homo sapiens]",25,6,19,6,361,41.4,10.64,38.08,"other biological processes","nucleus;other cell component","nucleic acid binding activity","SURF6","ENSG00000148296; ENSG00000281309","","","",426.5,404,445.4,592,497.7,480.8,0.8124164278892073,-0.29970868219240704,0.055081524919403324,1.2589940449054042,0.16217064350328098,0.7900277599795044,2652]
["High","O75688","Protein phosphatase 1B [OS=Homo sapiens]",29,13,39,1,479,52.6,5.05,86.64,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus","other molecular function","PPM1B","ENSG00000138032","MAPK signaling pathway","ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","MAPK signaling pathway",1333.3,1295.5,1320.7,1252.6,1239.8,1228.1,1.0615508668189761,0.08617350317851052,0.004409678263312901,2.355593096147832,0.04012910009317848,1.396540579337902,858]
["High","O75688-2","Isoform Beta-2 of Protein phosphatase 1B [OS=Homo sapiens]",35,13,38,1,387,42.7,5.2,82.57,"","","","PPM1B","","","","",51.6,64.7,63.4,68.1,59.7,59.2,0.9609625668449199,-0.057447861265057035,0.656286591123731,0.1829064689115394,0.7866573078744384,0.10421441848175828,6514]
["High","O75691","Small subunit processome component 20 homolog [OS=Homo sapiens]",20,40,75,40,2785,318.2,7.39,149.83,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","","UTP20","ENSG00000120800","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2670,2577.4,2600.2,2736.6,2798.4,2789,0.9427679000480538,-0.08502545724739403,0.009364997584259967,2.028492330316795,0.05892175756478792,1.2297243071568897,1241]
["High","O75694","nuclear pore complex protein nup155 [OS=Homo sapiens]",24,26,67,26,1391,155.1,6.16,169.68,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUP155","ENSG00000113569","","ISG15 antiviral mechanism; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis",3231.2,3419.9,3303,3211,3698.9,3316.9,0.9733347674736966,-0.03899200590456319,0.5959947200671183,0.22475758766894544,0.7425445626749736,0.12927747771028106,6267]
["High","O75695","Protein XRP2 [OS=Homo sapiens]",23,7,16,7,350,39.6,5.12,27.49,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","RP2","ENSG00000102218","Joubert syndrome; Ciliopathies","Trafficking of myristoylated proteins to the cilium","",752.2,848.9,861.7,716.4,646.2,688.2,1.2008972108445486,0.26411267081779227,0.026732762763122846,1.5729561556925442,0.10462627150599658,0.9803592510566759,1995]
["High","O75717","WD repeat and HMG-box DNA-binding protein 1 [OS=Homo sapiens]",35,31,103,31,1129,125.9,5.62,237.63,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","WDHD1","ENSG00000198554","Mesodermal commitment pathway","","",3627.9,3814.6,3598.4,4326.9,4461.1,4327.5,0.8418207464450459,-0.24841502994044135,1.0369196270299732E-3,2.9842549050286333,0.021532628850664978,1.6669029452976591,376]
["High","O75718","Cartilage-associated protein [OS=Homo sapiens]",38,14,64,14,401,46.5,5.73,125.6,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cell component","","CRTAP","ENSG00000170275","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",3411.4,3343.6,3425.1,3270.6,3263.6,3253.1,1.0401336425776262,0.05676890634431247,7.0121533923737265E-3,2.154148592188506,0.05074225550292313,1.2946302322127812,1079]
["High","O75746","Calcium-binding mitochondrial carrier protein Aralar1 [OS=Homo sapiens]",10,6,15,2,678,74.7,8.38,27.89,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A12","ENSG00000115840","","Mitochondrial protein import; Gluconeogenesis; Aspartate and asparagine metabolism","",211.8,238.9,219.6,243.7,246.4,247.4,0.9088813559322035,-0.13783611551717204,0.05109783486123694,1.2915975015822858,0.15530241128709146,0.8088218011899967,2569]
["High","O75781","Paralemmin-1 [OS=Homo sapiens]",17,5,6,5,387,42.1,5,11.9,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","signal transduction activity or receptor binding","PALM","ENSG00000099864","","","",258.3,309.9,293.9,306.3,261.3,253.1,1.0504447422931644,0.07100027232377565,0.5727337377873727,0.24204723332926636,0.7237263351098568,0.1404256238852093,6179]
["High","O75787","Renin receptor [OS=Homo sapiens]",25,8,15,8,350,39,6.1,37.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ATP6AP2","ENSG00000182220","ACE inhibitor pathway; Oxidative phosphorylation","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","Renin-angiotensin system",876.3,727.4,786.9,775.4,729.3,729.5,1.0700026855250202,0.09761441755050337,0.31954966033983123,0.49546163974151025,0.5064022220282935,0.295504397357784,4927]
["High","O75792","Ribonuclease H2 subunit A [OS=Homo sapiens]",21,7,11,7,299,33.4,5.25,31.7,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RNASEH2A","ENSG00000104889","","","DNA replication",365.5,380.4,386.6,416.9,400.5,405.1,0.9263803680981595,-0.11032341490599869,0.019470306568246745,1.710627210275053,0.08721982425982248,1.0593847927264106,1743]
["High","O75794","Cell division cycle protein 123 homolog [OS=Homo sapiens]",35,9,16,9,336,39.1,4.81,39.97,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","other cell component","","CDC123","ENSG00000151465","","","",610.2,624.6,636.8,797.3,793.1,767.1,0.7938918345705196,-0.3329856370895105,1.8473576969642162E-4,3.733449005600762,0.011010815952592824,1.9581804965978908,131]
["High","O75808-1","Calpain-15 [OS=Homo sapiens]",9,5,5,5,1086,117.2,6.71,12.48,"protein metabolism","other cell component","other molecular function","CAPN15","ENSG00000103326","","Degradation of the extracellular matrix","",201.6,194.8,215.8,177.9,177,183.1,1.137918215613383,0.18639687208300504,0.018751804563833695,1.7269569319680451,0.08577275338864294,1.0666506484241431,1707]
["High","O75815-1","Breast cancer anti-estrogen resistance protein 3 [OS=Homo sapiens]",6,4,4,4,825,92.5,7.96,3.91,"developmental processes;signal transduction;other biological processes","other membranes;other cell component","enzyme regulator activity;other molecular function","BCAR3","ENSG00000137936","","","",126.5,130.3,125.5,155.1,133.1,131.3,0.9113230035756853,-0.13396561049253694,0.1866224190591626,0.7290361854081885,0.35855015945224944,0.44545008002541586,4064]
["High","O75817","Ribonuclease P protein subunit p20 [OS=Homo sapiens]",11,1,4,1,140,15.6,8.94,11.68,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP7","ENSG00000172336","","tRNA processing in the nucleus","Ribosome biogenesis in eukaryotes",83.3,90.3,95.4,96.7,90.7,88.7,0.9742846794639622,-0.03758471514408289,0.6074636235343027,0.21647972360838136,0.7507242754915853,0.12451954051887609,6318]
["High","O75818-1","Ribonuclease P protein subunit p40 [OS=Homo sapiens]",8,2,8,2,363,41.8,6.67,17.47,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP40","ENSG00000124787","","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","Ribosome biogenesis in eukaryotes",171.8,193.5,167.7,175.2,189.1,192.9,0.9565685570710697,-0.06405972495471465,0.4499832818167388,0.3468036212237953,0.6287525884797954,0.2015202140073042,5588]
["High","O75820-1","Zinc finger protein 189 [OS=Homo sapiens]",9,5,9,1,626,72.9,8.5,7.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF189","ENSG00000136870; ENSGGOG00000003650; ENSPPAG00000034345; ENSPPYG00000019452; ENSPTRG00000021200","","Generic Transcription Pathway","Herpes simplex virus 1 infection",146.3,129.4,128.9,129.5,142,160.4,0.9367909238249595,-0.09420099664873899,0.44065770499567825,0.3558986317421315,0.6208327969336441,0.20702534852970902,5542]
["High","O75821","Eukaryotic translation initiation factor 3 subunit G [OS=Homo sapiens]",56,22,117,22,320,35.6,6.13,228.78,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3G","ENSG00000130811","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",4211.6,4060,4170.6,4463.7,4291.8,4530.1,0.9365177334858795,-0.09462178192474292,0.028875762286101236,1.5394665420858562,0.10923544182649149,0.9616364303823945,2064]
["High","O75822","Eukaryotic translation initiation factor 3 subunit J [OS=Homo sapiens]",40,8,12,8,258,29,4.83,19.73,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3J","ENSG00000104131","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",601,528.1,609.9,1608.4,510.5,463.9,0.6733002942542976,-0.5706779995534002,0.49479713161983696,0.3055728266768854,0.6656402487401253,0.17676042578394824,5804]
["High","O75828","Carbonyl reductase [NADPH] 3 [OS=Homo sapiens]",35,6,16,4,277,30.8,6.18,47,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CBR3","ENSG00000159231","Nuclear receptors meta-pathway; NRF2 pathway","Phase I - Functionalization of compounds","Arachidonic acid metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways",268,261.5,219.6,270.1,242.5,272.4,0.9542675159235668,-0.06753433201698333,0.5415305100917156,0.26637706998750393,0.7019040874495543,0.1537222285215127,6024]
["High","O75832","26S proteasome non-ATPase regulatory subunit 10 [OS=Homo sapiens]",52,10,64,10,226,24.4,6.1,103.3,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PSMD10","ENSG00000101843","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway","Degradation of DVL; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","",2307.4,2368.3,2274.9,2173.9,2139.3,2187.8,1.069158590986002,0.09647586751964968,0.008377182142589276,2.0769020417186996,0.05543138827909921,1.2562442443661896,1180]
["High","O75844","caax prenyl protease 1 homolog [OS=Homo sapiens]",16,7,48,7,475,54.8,7.49,80.53,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZMPSTE24","ENSG00000084073","Adipogenesis; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy","","Terpenoid backbone biosynthesis",1691.7,1814.1,1772.1,1751,1859.6,1847.1,0.9670557194422559,-0.04832907814579419,0.29399517269126235,0.5316598005087911,0.4806353241987807,0.31818431397146835,4776]
["High","O75864-1","Protein phosphatase 1 regulatory subunit 37 [OS=Homo sapiens]",9,4,5,4,691,74.7,5.06,9.53,"other biological processes","","enzyme regulator activity","PPP1R37","ENSG00000104866; ENSPPAG00000031033","","","",154.5,133.7,129.7,112.9,116.8,118.8,1.1991391678622667,0.2619991025666235,0.04257109118203909,1.3708852178457707,0.13954453398377886,0.8552871703338938,2382]
["Medium","O75865-1","Trafficking protein particle complex subunit 6A [OS=Homo sapiens]",6,1,1,1,159,17.6,5.26,0,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC6A","ENSG00000007255","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",16.3,24.1,18.4,16.5,13.5,18.3,1.2173913043478264,0.2837929660005916,0.2673652957442277,0.5728949652300146,0.45146804264077206,0.34537298598385174,4624]
["High","O75874","Isocitrate dehydrogenase [NADP] cytoplasmic [OS=Homo sapiens]",73,28,435,27,414,46.6,7.01,794.24,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","IDH1","ENSG00000138413","Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism","Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration","Citrate cycle (TCA cycle); Glutathione metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Peroxisome; Central carbon metabolism in cancer",13891.5,14100.9,14198.8,14493.7,14094.8,14528.3,0.9785327297016474,-0.03130798834947451,0.1366455069349619,0.8644046438500856,0.29408162021724993,0.5315321175795079,3628]
["High","O75879","Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial [OS=Homo sapiens]",13,5,11,5,557,61.8,8.63,16.71,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","other molecular function","GATB","ENSG00000059691","","","Aminoacyl-tRNA biosynthesis; Metabolic pathways",246.7,268.9,252.6,291.6,277.5,275.7,0.9093276515151516,-0.1371278708273882,0.03743106815256315,1.4267677794539724,0.12857975368905106,0.8908274105203079,2273]
["High","O75880","Protein SCO1 homolog, mitochondrial [OS=Homo sapiens]",8,3,5,3,301,33.8,8.88,9.23,"cell organization and biogenesis;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO1","ENSG00000133028","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","",388.4,362.2,396.8,364.3,351.6,337.1,1.0896486229819562,0.12386298673888939,0.07345915629529863,1.133954063989641,0.19676469720538312,0.7060528184260384,2915]
["High","O75882-1","Attractin [OS=Homo sapiens]",5,6,10,6,1429,158.4,7.31,11.5,"cell adhesion;stress response;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","ATRN","ENSG00000088812","","","",240,255.5,253.1,213.1,218.4,216.7,{"$f":"AVERAGE(T706:V706)/AVERAGE(W706:Y706)","v":1.1548904659055845},{"$f":"LOG(Z706,2)","v":0.20775602758212106},{"$f":"TTEST(T706:V706,W706:Y706,2,2)","v":2.7168893491113437E-3},{"$f":"-LOG10(AB706)","v":2.565928048755064},{"$f":"AB706*7808/AF706","v":0.031948000057020136},{"$f":"-LOG10(AD706)","v":1.4955563234644462},664]
["High","O75884-1","Putative hydrolase RBBP9 [OS=Homo sapiens]",6,2,3,2,186,21,6.2,7.2,"other biological processes","nucleus","other molecular function","RBBP9","ENSG00000089050; ENSPPAG00000038694; ENSPTRG00000013289","","","",263.6,301.5,277.6,266.4,312.1,272.7,0.990014097744361,-0.01447902565363492,0.8830663140590486,0.054006681758189574,0.9320061881823536,0.030581204078929405,7398]
["High","O75886","Signal transducing adapter molecule 2 [OS=Homo sapiens]",17,8,16,7,525,58.1,5.07,18.11,"cell organization and biogenesis;other metabolic processes;transport;signal transduction","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STAM2","ENSG00000115145","EGF/EGFR signaling pathway","Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell","Endocytosis; JAK-STAT signaling pathway",507.7,467.1,473.7,439.2,430.8,462.1,1.0873808272652203,0.12085729582613973,0.06855479301744456,1.1639621760566838,0.1876185853067673,0.7267241430551249,2853]
["High","O75907","Diacylglycerol O-acyltransferase 1 [OS=Homo sapiens]",10,4,6,4,488,55.2,9.32,20.93,"cell organization and biogenesis;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","DGAT1","ENSG00000185000; ENSG00000285482","Triacylglyceride synthesis; Statin inhibition of cholesterol production; Glycerolipids and glycerophospholipids; Congenital generalized lipodystrophy (CGL); Vitamin A and carotenoid metabolism","Neutrophil degranulation; Acyl chain remodeling of DAG and TAG; Triglyceride biosynthesis","Glycerolipid metabolism; Retinol metabolism; Metabolic pathways; Fat digestion and absorption",384.2,375.8,365.1,255,272.1,265.3,1.4198637051993939,0.5057524499622669,1.175654786948681E-4,3.9297201834746573,0.009179512576495302,2.037180378816022,100]
["High","O75909","Cyclin-K [OS=Homo sapiens]",18,7,20,7,580,64.2,8.41,44.16,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNK","ENSG00000090061","Male infertility","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes","",784.9,807.4,820.8,799.5,799.4,804.6,1.0039941751612234,0.005750899278332312,0.7780579835179825,0.1089880367075389,0.8706042899553464,0.06017919716099554,6978]
["High","O75915","PRA1 family protein 3 [OS=Homo sapiens]",20,3,9,3,188,21.6,9.77,6.29,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","ARL6IP5","ENSG00000144746","","Glutamate Neurotransmitter Release Cycle","",93.7,100.9,97.2,106.9,110.7,116.4,0.8736526946107784,-0.1948682194435237,0.015216592285095181,1.81768259575745,0.0758207738111188,1.120211787567405,1567]
["High","O75923-1","dysferlin [OS=Homo sapiens]",16,24,35,24,2080,237.1,5.64,65.88,"cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYSF","ENSG00000135636","","Smooth Muscle Contraction","",882.9,891.6,870.1,884.2,916.2,875,0.9884877027734169,-0.01670507658908705,0.5028678394347277,0.29854613849450945,0.6716373743254112,0.17286514485729168,5846]
["High","O75925","E3 SUMO-protein ligase PIAS1 [OS=Homo sapiens]",11,5,9,4,651,71.8,7.3,16,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS1","ENSG00000033800","Androgen receptor signaling pathway; Interleukin-11 signaling pathway; Mesodermal commitment pathway; TGF-beta signaling pathway; Immune response to tuberculosis; Interferon type I signaling pathways","SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway; Hepatitis C",196.6,205.2,204.1,195.2,210,189.5,1.0188330250546493,0.026917629850738072,0.6060499230097485,0.21749159960493902,0.7498079224940764,0.12504997512107927,6311]
["High","O75928-1","E3 SUMO-protein ligase PIAS2 [OS=Homo sapiens]",10,4,7,3,621,68.2,7.52,10.59,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS2","ENSG00000078043; ENSPTRG00000009998","Androgen receptor signaling pathway; TGF-beta signaling pathway","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway",23.2,34.6,29.2,38.1,29.7,24.5,0.9425785482123511,-0.08531524690968346,0.7489060201066793,0.12557267830840682,0.8522749169207043,0.06942029297618231,6861]
["High","O75934","Pre-mRNA-splicing factor spf27 [OS=Homo sapiens]",48,10,26,10,225,26.1,5.66,64.74,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","","BCAS2","ENSG00000116752","","mRNA Splicing - Major Pathway","Spliceosome",1470.3,1319.5,1400.1,1218.6,1133.7,1107.7,1.2109537572254334,0.2761437737891878,0.011441570262332435,1.9415143680720588,0.0655916157182758,1.18315167099019,1362]
["High","O75935","Dynactin subunit 3 [OS=Homo sapiens]",24,4,11,4,186,21.1,5.47,18.4,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DCTN3","ENSG00000137100","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection",314.3,299.8,318.6,276.3,273.5,294.5,1.1047021200994909,0.1436574032904865,0.0276019580725433,1.5590601081544495,0.10642769808909536,0.9729453310465014,2025]
["High","O75937","DnaJ homolog subfamily C member 8 [OS=Homo sapiens]",16,4,8,4,253,29.8,9.06,12.9,"","non-structural extracellular;cytosol;nucleus","other molecular function","DNAJC8","ENSG00000126698; ENSG00000285317","mRNA processing","mRNA Splicing - Major Pathway","",602.9,441,571,1255.9,544.5,430.9,0.7237484874288531,-0.4664396668890085,0.47809951716597515,0.3204816948991877,0.6520525816649666,0.18571738125247794,5725]
["High","O75940","Survival of motor neuron-related-splicing factor 30 [OS=Homo sapiens]",37,7,16,7,238,26.7,7.24,32.33,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","SMNDC1","ENSG00000119953","","mRNA Splicing - Major Pathway","Spliceosome",691.3,753.6,744,941.3,822.8,778.3,0.8609581497797357,-0.21598498336587446,0.0875886288819332,1.0575522720782464,0.22089535345934574,0.6558134194304661,3096]
["High","O75943-1","cell cycle checkpoint protein RAD17 [OS=Homo sapiens]",9,6,8,6,681,77,7.06,13.11,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","RAD17","ENSG00000152942; ENSG00000276618","miRNA regulation of DNA damage response; Gastric cancer network 2; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","",242.1,252,244.8,233.2,233.8,221.1,1.07382647870949,0.10276088482193257,0.029081812916723012,1.536378523700632,0.10980212536449384,0.9593892534639016,2068]
["High","O75947-1","ATP synthase subunit d, mitochondrial [OS=Homo sapiens]",41,6,20,6,161,18.5,5.3,16.06,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5PD","ENSG00000167863; ENSGGOG00000013716; ENSPTRG00000009628","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",639.4,549,662.3,744.8,500.7,463.6,1.0828506231349835,0.11483424005987058,0.6444931679179255,0.1907816821139477,0.7777747534935338,0.10914615812401261,6470]
["High","O75953","dnaJ homolog subfamily B member 5 [OS=Homo sapiens]",30,8,18,8,348,39.1,9.04,37.35,"stress response;other biological processes","cytosol","other molecular function","DNAJB5","ENSG00000137094","","","",483.8,359.8,392.5,373.6,392.9,329.2,1.1281372638495937,0.17394261545582762,0.32374764140727985,0.48979338685674473,0.5109807123727594,0.29159549256229056,4947]
["High","O75954","tetraspanin-9 [OS=Homo sapiens]",14,2,3,2,239,26.8,7.68,9.46,"","plasma membrane;other membranes","","TSPAN9","ENSG00000011105","","","",16.9,28.9,28.8,23.7,22.9,28.2,0.997326203208556,-3.8626396323990634E-3,0.988403640863921,5.065663508527639E-3,0.9943893348621949,0.002443542286098092,7761]
["High","O75955","Flotillin-1 [OS=Homo sapiens]",34,13,37,12,427,47.3,7.49,78.73,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","FLOT1","ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules","Insulin signaling pathway",926.4,1051.8,992.9,996.9,1135,988.9,0.9520315303768265,-0.07091873987829775,0.45007968468787624,0.346710589432259,0.6287747679447017,0.20150489438952868,5589]
["High","O75962-1","Triple functional domain protein [OS=Homo sapiens]",5,12,14,12,3097,346.7,6.37,23.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;kinase activity;other molecular function","TRIO","ENSG00000038382","Microtubule cytoskeleton regulation; Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; G alpha (q) signalling events; DCC mediated attractive signaling","",394.1,372.4,380.9,325.7,336.4,315,1.1742912700849453,0.2317902975349093,0.003013895816047399,2.5208717643962197,0.03342684450525297,1.4759046188796967,704]
["High","O75964","ATP synthase subunit g, mitochondrial [OS=Homo sapiens]",39,4,21,4,103,11.4,9.64,39.98,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5MG","ENSG00000167283","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis",617.4,719.9,679.7,598.7,698.4,654.3,1.0336168904376346,0.04770155056196281,0.6260146264995939,0.20341551961088877,0.764813363121394,0.11644453250080918,6391]
["Low","O75969","A-kinase anchor protein 3 [OS=Homo sapiens]",1,1,1,1,853,94.7,6.18,0,"developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","AKAP3","ENSG00000111254","G protein signaling pathways","","",32.6,26.9,26.5,29.9,32.5,36.6,0.8686868686868687,-0.20309186537751162,0.1930433519094335,0.7143451501588822,0.36700328505207125,0.43533004835389927,4107]
["High","O75970","multiple PDZ domain protein [OS=Homo sapiens]",11,16,24,16,2070,221.5,5.06,47.36,"","plasma membrane;other membranes;other cell component","other molecular function","MPDZ","ENSG00000107186","","","Tight junction",1232.8,1201.9,1193.9,1440,1353.4,1394.2,0.8665106504919284,-0.20671061287934633,2.537867066393351E-3,2.5955311300127137,0.03120577331401462,1.5057650506460538,635]
["High","O75976","Carboxypeptidase D [OS=Homo sapiens]",15,16,26,16,1380,152.8,6.05,45.84,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","CPD","ENSG00000108582","","Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle; RND1 GTPase cycle","",777.5,705.9,738.8,747.8,742,716.9,1.007024063080618,0.010098157299318235,0.8315557047632423,0.08010865268502672,0.9037843739965751,0.04393517168563929,7184]
["High","O76003","glutaredoxin-3 [OS=Homo sapiens]",36,11,67,11,335,37.4,5.39,164.17,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","GLRX3","ENSG00000108010","","Iron uptake and transport","",3252.3,3254.7,3266.6,3385.1,3507.9,3459.3,0.9440993788819877,-0.08298936467103131,5.8399309990712425E-3,2.233592284206032,0.04671944799256994,1.3305022972140883,976]
["High","O76021","Ribosomal L1 domain-containing protein 1 [OS=Homo sapiens]",48,24,127,24,490,54.9,10.13,233.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RSL1D1","ENSG00000171490","","","",5749.6,5702.3,5925.3,6517.9,6465,6718.9,0.8820107807408462,-0.18113180506114016,1.6638289143127115E-3,2.778891332726711,0.026675926412635834,1.5738804892827096,487]
["High","O76024","Wolframin [OS=Homo sapiens]",18,14,33,14,890,100.2,8.05,64.28,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","WFS1","ENSG00000109501","CAMKK2 pathway","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes","Protein processing in endoplasmic reticulum",1255.2,1306,1287.6,1179.5,1300.2,1231.3,1.0371328482888709,0.0526007034973334,0.2931230043458433,0.5329500967153861,0.47971167845993395,0.3190197086156768,4771]
["High","O76031","ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial [OS=Homo sapiens]",39,20,48,20,633,69.2,7.58,90.67,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","CLPX","ENSG00000166855","","","",2321.3,2305.3,2241.9,2422.2,2394,2405.8,0.9510523400720021,-0.07240335455393672,0.009989979617121628,2.000435397878185,0.06112990662263767,1.2137462676046933,1276]
["High","O76039-1","Cyclin-dependent kinase-like 5 [OS=Homo sapiens]",3,2,2,1,1030,115.5,9.54,2.72,"","","","CDKL5","","","","",13.1,18.1,14,22.2,23.9,26.5,0.6225895316804408,-0.6836467755805629,0.0099818629901913,2.000788395500977,0.0611761273370594,1.2134180188416732,1274]
["High","O76041-2","Isoform 2 of Nebulette [OS=Homo sapiens]",10,3,3,2,270,31.2,8.31,7.4,"","","","NEBL","","","","",76.5,93.7,88.6,115.6,105.2,109.5,0.783530124129579,-0.3519393522930179,0.01584067600126668,1.8002262888225704,0.07764218343872582,1.1099022599650665,1593]
["High","O76062","Delta(14)-sterol reductase [OS=Homo sapiens]",5,2,3,2,418,46.4,8.87,8.9,"other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","TM7SF2","ENSG00000149809","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Steroid biosynthesis; Metabolic pathways",253.9,214.5,217.9,207.7,215.2,209.1,1.0859177215189872,0.1189147962791188,0.23064639955174548,0.6370533204487939,0.4107862882527438,0.38638406126647123,4384]
["High","O76064","E3 ubiquitin-protein ligase RNF8 [OS=Homo sapiens]",11,4,5,4,485,55.5,7.33,9.64,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","RNF8","ENSG00000112130","ATM signaling in development and disease ; 3q29 copy number variation syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome","Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Nonhomologous End-Joining (NHEJ)","",105.2,122.5,142.2,146.8,132,120.6,0.9261392088132199,-0.11069903231997726,0.49480221688889275,0.3055683632457134,0.6655324219583936,0.17683078266167065,5805]
["High","O76070","Gamma-synuclein [OS=Homo sapiens]",76,8,15,7,127,13.3,4.86,35.71,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","cytoskeleton;other cell component","other molecular function","SNCG","ENSG00000173267","","","",539,509.4,563.7,614.5,568.4,604.7,0.9018236742000447,-0.1490827115445604,0.04984528156465135,1.302375946427991,0.15298426039968466,0.8153532487457318,2544]
["High","O76071","Probable cytosolic iron-sulfur protein assembly protein Ciao1 [OS=Homo sapiens]",33,8,19,8,339,37.8,4.97,62.4,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","","CIAO1","ENSG00000144021","","Cytosolic iron-sulfur cluster assembly","",615,567.8,648.5,635,610.1,632.8,0.9751850471271101,-0.036252090136121635,0.5639114544659891,0.24878908370416605,0.7178057770574572,0.1439930506919974,6134]
["High","O76074","cGMP-specific 3',5'-cyclic phosphodiesterase [OS=Homo sapiens]",8,6,8,6,875,99.9,6.09,8.24,"other metabolic processes;signal transduction","cytosol","other molecular function","PDE5A","ENSG00000138735","Phosphodiesterases in neuronal function","cGMP effects; RHOBTB1 GTPase cycle","Purine metabolism; Metabolic pathways; cGMP-PKG signaling pathway",85.3,80,68.6,80.7,78.9,77.3,0.987336428872942,-0.01838633688780386,0.8519311840608582,0.06959548456388798,0.9158582796567784,0.03817172406664786,7263]
["High","O76075","DNA fragmentation factor subunit beta [OS=Homo sapiens]",12,3,4,3,338,39.1,9,5.11,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DFFB","ENSG00000169598","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis","Apoptosis induced DNA fragmentation","Apoptosis",136.9,139.6,122.2,159.7,151.1,155.6,0.8548456260720412,-0.22626418320316577,0.019219629516803238,1.716254988174172,0.08669374192212576,1.0620122513909305,1731]
["High","O76080","AN1-type zinc finger protein 5 [OS=Homo sapiens]",29,4,5,4,213,23.1,8.51,17.66,"developmental processes;signal transduction;other biological processes","other cell component","nucleic acid binding activity;other molecular function","ZFAND5","ENSG00000107372","","","",285.2,277.1,283.7,305.8,327.4,310.9,0.896091515729266,-0.15828201601226777,0.009400364282066073,2.0268553163337346,0.05885969872844579,1.2301819651536419,1247]
["High","O76094","Signal recognition particle subunit SRP72 [OS=Homo sapiens]",36,20,56,20,671,74.6,9.26,128.38,"transport","cytosol;ER/Golgi;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","SRP72","ENSG00000174780","","SRP-dependent cotranslational protein targeting to membrane","Protein export",2107.5,2363.1,2211.5,2171,2504.1,2328.6,0.9540814141096847,-0.0678157146935095,0.42744701980906397,0.369117706504107,0.6088118078564705,0.21551693304895123,5482]
["Medium","O76095-1","Protein JTB [OS=Homo sapiens]",9,1,2,1,146,16.3,8.28,2.18,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","other molecular function","JTB","ENSG00000143543; ENSGGOG00000005608; ENSPPAG00000028370; ENSPTRG00000001369","","","",45.4,40.3,41.3,45.2,36.3,43.3,1.017628205128205,0.02521056279727977,0.8259220356180045,0.0830609467461424,0.9004187732624098,0.0455554587633911,7162]
["High","O77932","Decapping and exoribonuclease protein [OS=Homo sapiens]",4,2,3,2,396,44.9,7.69,4.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","DXO","ENSG00000204348; ENSG00000206346; ENSG00000224313; ENSG00000225682; ENSG00000234798; ENSG00000236765","","","",86.2,74.9,59.2,87.4,81.7,103.5,0.8081438004402054,-0.30731606710432646,0.16237645493221434,0.7894769445181374,0.32802984737664415,0.4840866381138457,3865]
["High","O94760-1","N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [OS=Homo sapiens]",29,7,24,6,285,31.1,5.81,61.15,"other metabolic processes;signal transduction;other biological processes","cytosol","other molecular function","DDAH1","ENSG00000153904; ENSMFAG00000037521; ENSMMUG00000014573; ENSMNEG00000044101; ENSRBIG00000034663; ENSRROG00000009892","Mesodermal commitment pathway; Nitric oxide metabolism in cystic fibrosis","eNOS activation","",881.3,826.6,840.1,930.2,896.2,923,0.9267476540336074,-0.10975153687245873,0.025947037663235133,1.5859122177749911,0.10289206199824272,0.9876181292544739,1969]
["High","O94761","ATP-dependent DNA helicase Q4 [OS=Homo sapiens]",6,5,7,5,1208,133,8.09,14.84,"","","","","","","","",151.3,151.7,140.2,124.1,122,111.5,1.239373601789709,0.3096111448658704,6.241180637055351E-3,2.2047332475519354,0.048488694939431025,1.314359504649808,1005]
["High","O94762-1","ATP-dependent DNA helicase Q5 [OS=Homo sapiens]",9,8,9,8,991,108.8,8.56,13.93,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RECQL5","ENSG00000108469","","","",427.2,334.1,346.9,391.4,388.5,404.5,0.9356636271529887,-0.09593812347395977,0.4384677533341539,0.358062340870345,0.6191998947428239,0.2081691261504459,5529]
["High","O94763-1","Unconventional prefoldin RPB5 interactor 1 [OS=Homo sapiens]",19,9,15,9,535,59.8,5.05,26.66,"other biological processes","cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","URI1","ENSG00000105176","","","",510.6,512.2,507.4,553.2,584.9,564.1,0.8989542944424862,-0.15368032826600636,3.6627489738705965E-3,2.43619284464382,0.0370450051657793,1.4312703403209206,772]
["High","O94766","Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 [OS=Homo sapiens]",26,8,12,8,335,37.1,8.27,26.73,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","B3GAT3","ENSG00000149541","Proteoglycan biosynthesis","A tetrasaccharide linker sequence is required for GAG synthesis; Defective B3GAT3 causes JDSSDHD","Glycosaminoglycan biosynthesis; Glycosaminoglycan biosynthesis; Metabolic pathways",514.5,508.1,517.3,443.8,464.7,448.4,1.1348662392217557,0.18252226457915866,9.0402191175024949E-4,3.0438210429351513,0.02040058695649118,1.6903573370692926,346]
["High","O94768","Serine/threonine-protein kinase 17B [OS=Homo sapiens]",5,2,2,2,372,42.3,5.25,2.06,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus","kinase activity;other molecular function","STK17B","ENSG00000081320","","","",60.1,55.6,61,53.3,52,46.3,1.1655672823218997,0.22103228638052508,0.037171761174749976,1.429786861816413,0.12830995192415906,0.891739657747214,2262]
["High","O94776","Metastasis-associated protein MTA2 [OS=Homo sapiens]",34,22,66,20,668,75,9.66,131.78,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MTA2","ENSG00000149480","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","",2249.6,2188.3,2160.9,2215.4,2237.8,2241.8,0.9856310679611648,-0.020880363116837466,0.308040294811472,0.5113924696370732,0.495096463953885,0.30531017544754946,4858]
["High","O94782","Ubiquitin carboxyl-terminal hydrolase 1 [OS=Homo sapiens]",11,7,7,7,785,88.2,5.45,13.61,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus","other molecular function","USP1","ENSG00000162607","miR-517 relationship with ARCN1 and USP1; DNA repair pathways, full network","Fanconi Anemia Pathway; Recognition of DNA damage by PCNA-containing replication complex","Fanconi anemia pathway",306.2,320.6,344,383.8,364.4,376.6,0.8630867709815075,-0.212422485921402,0.014318958250332461,1.8440885771810582,0.07297808486853515,1.1368075378190081,1532]
["High","O94788-1","retinal dehydrogenase 2 [OS=Homo sapiens]",5,5,11,2,518,56.7,6.05,23.03,"cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","ALDH1A2","ENSG00000128918","Ethanol effects on histone modifications; Tryptophan metabolism; 22q11.2 copy number variation syndrome; Vitamin A and carotenoid metabolism","RA biosynthesis pathway","Retinol metabolism; Metabolic pathways",399.8,377.1,363.6,438.5,410,423.4,0.8966899913515213,-0.1573188000922203,0.030765304816675363,1.5119387776491102,0.11363079470605546,0.9445039559618823,2114]
["High","O94804","Serine/threonine-protein kinase 10 [OS=Homo sapiens]",13,10,11,9,968,112.1,6.95,16.66,"cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","kinase activity;other molecular function","STK10","ENSG00000072786","","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation","Progesterone-mediated oocyte maturation",186.7,178.7,193,202.2,193.9,198.4,0.9392767031118587,-0.09037786842336588,0.06564024784775183,1.1828297877848835,0.18239112284528336,0.738996303031328,2810]
["High","O94808","Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [OS=Homo sapiens]",42,25,94,18,682,76.9,7.37,224.33,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","GFPT2","ENSG00000131459","","Synthesis of UDP-N-acetyl-glucosamine","Alanine, aspartate and glutamate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars; Insulin resistance; Diabetic cardiomyopathy",2445.9,2576.9,2454.8,1625.7,1771.2,1741.6,1.455210664590834,0.5412280210101813,2.2002012091363671E-4,3.6575376009860383,0.012098007775307573,1.9172861407104593,142]
["High","O94819","Kelch repeat and BTB domain-containing protein 11 [OS=Homo sapiens]",6,2,3,2,623,65.7,6.07,7.41,"","","","KBTBD11","ENSG00000176595; ENSG00000273645","","","",66.1,45,46.2,39.9,43.3,37.7,1.3010752688172045,0.3797044261665633,0.1595912910918936,0.79699081181944,0.3239960480617538,0.48946028706326566,3846]
["High","O94822","E3 ubiquitin-protein ligase listerin [OS=Homo sapiens]",18,25,40,25,1766,200.4,6.25,71.97,"protein metabolism;other metabolic processes","cytosol;other cell component","translation activity;other molecular function","LTN1","ENSG00000198862","","Antigen processing: Ubiquitination & Proteasome degradation","",1784.1,1882.2,1804.2,1981.7,1911.7,1931.2,0.9392061257425401,-0.09048627678270652,0.031782718525921266,1.49780895828307,0.11590820469425187,0.9358858209188731,2141]
["High","O94826","Mitochondrial import receptor subunit TOM70 [OS=Homo sapiens]",48,25,95,25,608,67.4,7.12,193.99,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TOMM70","ENSG00000154174","Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation","Mitochondrial protein import; Ub-specific processing proteases; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PINK1-PRKN Mediated Mitophagy","",3595.1,3606.4,3550.3,3497.8,3403.8,3516,1.032080325602826,0.045555258395978994,0.04527151498156655,1.344174971881476,0.1444544294957383,0.8402691365746298,2447]
["High","O94829","Importin-13 [OS=Homo sapiens]",10,7,10,7,963,108.1,5.3,17.08,"transport","nucleus;other cell component","other molecular function","IPO13","ENSG00000117408","","","Nucleocytoplasmic transport",315.1,336.1,304.8,302.5,317.1,307,1.03172890135981,0.045063935834839565,0.3898611719908326,0.40909001597851075,0.5739132788281336,0.2411537267165921,5304]
["High","O94830","Phospholipase DDHD2 [OS=Homo sapiens]",14,6,6,6,711,81,5.39,5.24,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","DDHD2","ENSG00000085788","","Synthesis of PA","",114.7,127.4,121.3,115.7,130.3,135.5,0.9525557011795545,-0.0701246374877769,0.43549375854137307,0.36101806488241417,0.6163377318635203,0.21018124418151862,5517]
["High","O94832","Unconventional myosin-Id [OS=Homo sapiens]",8,7,8,7,1006,116.1,9.39,14.9,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1D","ENSG00000176658","","","Pathogenic Escherichia coli infection",389.9,375.6,350.1,264.6,300.5,308.5,1.277014652014652,0.35277507810845954,0.010612736063517748,1.974172636447127,0.0628712012017804,1.2015482420464827,1318]
["High","O94842","TOX high mobility group box family member 4 [OS=Homo sapiens]",9,4,7,4,621,66.2,5.06,12.49,"other biological processes","nucleus;other cell component","nucleic acid binding activity","TOX4","ENSG00000092203","","","",199.1,271,249.5,217.6,243,233.7,1.036439579432522,0.05163601515083291,0.7275340863198831,0.1381466543642647,0.836364273555013,0.07760452694152553,6792]
["High","O94854","Uncharacterized protein KIAA0754 [OS=Homo sapiens]",9,7,11,7,1291,135.1,4.21,28.81,"","","","KIAA0754","","","","",184.2,180.3,200.4,197.7,163.4,179.6,1.04475679674496,0.06316714425338484,0.5271881018968366,0.2780343998913961,0.6899572074439323,0.16117784425880463,5966]
["High","O94855","Protein transport protein Sec24D [OS=Homo sapiens]",18,15,33,15,1032,112.9,7.25,62.42,"cell organization and biogenesis;transport;developmental processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC24D","ENSG00000150961","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",1412.7,1429.6,1411.4,1348.2,1492.3,1417.2,0.999060525635907,-1.3560120751932789E-3,0.9762075897525635,0.010457820143087196,0.9874632544096406,0.005479056414460836,7719]
["Low","O94856","Neurofascin [OS=Homo sapiens]",1,1,2,1,1347,149.9,6.65,0,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","NFASC","ENSG00000163531","","Neutrophil degranulation; Neurofascin interactions; Interaction between L1 and Ankyrins","Cell adhesion molecules",86.2,95.5,84.1,105,100,106.8,0.8524695317511223,-0.23027982342161063,0.019345462635387323,1.7134208799208501,0.08690988047014052,1.0609308473748624,1738]
["High","O94864-1","STAGA complex 65 subunit gamma [OS=Homo sapiens]",17,3,9,3,414,46.2,5.12,0,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SUPT7L","ENSG00000119760; ENSPTRG00000011777","","HATs acetylate histones","",65.8,54.2,59.5,55.7,54.3,53.9,1.0951799877974375,0.13116798961095497,0.20056660651159547,0.6977413734840449,0.3759059202214444,0.42492083443713646,4166]
["High","O94874-1","E3 UFM1-protein ligase 1 [OS=Homo sapiens]",16,11,28,11,794,89.5,6.79,48.52,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UFL1","ENSG00000014123","","Antigen processing: Ubiquitination & Proteasome degradation","",1429.2,1411.8,1497.7,1312.5,1415,1346.3,1.065025283519073,0.09088768019252909,0.0916548390412663,1.0378446009315399,0.226039476700634,0.6458157067992415,3166]
["High","O94875-1","Sorbin and SH3 domain-containing protein 2 [OS=Homo sapiens]",1,1,1,1,1100,124,8.31,2.53,"cell organization and biogenesis;developmental processes;signal transduction","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SORBS2","ENSG00000154556","Extracellular vesicles in the crosstalk of cardiac cells","","",31.4,32.7,40.2,37.4,33,41.8,0.9295900178253119,-0.1053335180890272,0.5200149611054851,0.28398416130349735,0.6841241476514958,0.16486507993547198,5935]
["High","O94876","Transmembrane and coiled-coil domains protein 1 [OS=Homo sapiens]",15,7,9,6,653,72,6.55,15.21,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TMCC1","ENSG00000172765","","","",275.4,273.1,234.4,256.8,218,233.3,1.1056347973450076,0.1448749271042523,0.2260674917603322,0.645761884201045,0.4064321841272562,0.39101190890463866,4343]
["High","O94880","PHD finger protein 14 [OS=Homo sapiens]",14,9,18,9,888,100,5.33,23.63,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF14","ENSG00000106443","","","",472.3,458.2,489.9,555.1,538.2,542.8,{"$f":"AVERAGE(T770:V770)/AVERAGE(W770:Y770)","v":0.8681620927816148},{"$f":"LOG(Z770,2)","v":-0.20396366440658323},{"$f":"TTEST(T770:V770,W770:Y770,2,2)","v":2.351317598440374E-3},{"$f":"-LOG10(AB770)","v":2.6286887056541617},{"$f":"AB770*7808/AF770","v":0.030496823602362857},{"$f":"-LOG10(AD770)","v":1.5157453922533506},602]
["High","O94885","SAM and SH3 domain-containing protein 1 [OS=Homo sapiens]",7,6,7,6,1247,136.6,6.09,16.32,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","SASH1","ENSG00000111961","","","",231.3,240.9,234.5,327.3,265,292.2,0.7989824759751273,-0.3237642339131221,0.03146139457624136,1.5022220304939569,0.11522071709722914,0.938469426189856,2132]
["High","O94887-1","FERM, RhoGEF and pleckstrin domain-containing protein 2 [OS=Homo sapiens]",6,4,6,4,1054,119.8,8.79,7.26,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity","FARP2","ENSG00000006607","","RAC1 GTPase cycle; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Rap1 signaling pathway; Adherens junction",169.9,186.2,190.8,142.8,148.5,133.5,1.2874293785310738,0.3644932959561372,0.006150626942342048,2.211080613700628,0.04802409516580671,1.3185408090419926,1000]
["High","O94888","UBX domain-containing protein 7 [OS=Homo sapiens]",41,15,50,15,489,54.8,5.16,88.4,"","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","UBXN7","ENSG00000163960","3q29 copy number variation syndrome","Neddylation","",1741.8,1767.9,1811.7,2011.9,1839.6,1967.7,0.9144555952708275,-0.1290149785360472,0.04044505111959398,1.3931346113308098,0.1350128085257759,0.8696250284813275,2339]
["High","O94889","Kelch-like protein 18 [OS=Homo sapiens]",8,4,7,3,574,63.6,5.6,13.5,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","","","KLHL18","ENSG00000114648","","","",58,58.8,60.4,53.9,53,57.9,1.0752427184466018,0.10466236137179974,0.06781222642579197,1.1686919965378626,0.1863702442564533,0.7296234256021631,2841]
["High","O94898","Leucine-rich repeats and immunoglobulin-like domains protein 2 [OS=Homo sapiens]",2,1,1,1,1065,118.9,5.55,3.51,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","LRIG2","ENSG00000198799","","","Axon guidance",76.2,57.7,60.9,47.7,51.9,60.7,1.2152214597629445,0.2812192519277941,0.16967329557480498,0.7703865047484001,0.33753097881479677,0.4716863611710361,3925]
["High","O94901-1","SUN domain-containing protein 1 [OS=Homo sapiens]",28,15,51,14,812,90,7.08,133.9,"","","","","","","","",1847.9,1988,1982.1,1698.3,1756.3,1761.3,1.1154354953124102,0.15760708616506056,0.0159615443078215,1.7969250921883446,0.07798982350154585,1.1079620625076818,1598]
["High","O94903","Pyridoxal phosphate homeostasis protein [OS=Homo sapiens]",42,11,47,11,275,30.3,7.5,93.29,"","cytosol;other cell component","other molecular function","PLPBP","ENSG00000147471","","","",2278.4,2273.9,2288.7,2115.7,2138,2148,1.0686223971757502,0.09575215992611152,1.5354475546093484E-4,3.8137650129120506,0.010074600425537641,1.996772169645946,119]
["High","O94905-1","Erlin-2 [OS=Homo sapiens]",52,18,80,15,339,37.8,5.62,160.07,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ERLIN2","ENSG00000147475; ENSGGOG00000012855; ENSPPAG00000034728; ENSPTRG00000020158","","ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions","",3417.3,3637,3417.8,3332.9,3695.8,3558.8,0.9891003541912634,-0.015811190536848634,0.7797930366672783,0.10802064725841908,0.8712970850455222,0.059833738910677,6988]
["High","O94906-1","Pre-mRNA-processing factor 6 [OS=Homo sapiens]",48,43,144,43,941,106.9,8.25,301.32,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PRPF6","ENSG00000101161; ENSGGOG00000016876; ENSPPAG00000008686; ENSPTRG00000013765","mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",6504.8,5714.6,5842.3,5843.1,5738.8,5869.5,1.034971406305511,0.049590910187325594,0.4583446945469211,0.3388077913507273,0.6357710739069746,0.1966992353522941,5629]
["High","O94913","Pre-mRNA cleavage complex 2 protein Pcf11 [OS=Homo sapiens]",10,12,21,12,1555,172.9,8.48,42.05,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCF11","ENSG00000165494","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",854.1,761.1,834.8,858.9,815.9,786.3,0.9954898216244769,-0.006521529686899331,0.9216013953212869,0.03545687639061506,0.9567695379163155,0.019192660409858592,7521]
["High","O94915-1","protein furry homolog-like [OS=Homo sapiens]",4,9,9,9,3013,339.4,5.58,17.4,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","","FRYL","ENSG00000075539","","","",380,409.8,374.3,361.3,360.6,395,1.0422598263049512,0.05971497377220411,0.37604088392390644,0.42476493513271024,0.5600090066141258,0.2518049881877981,5243]
["High","O94916","nuclear factor of activated T-cells 5 [OS=Homo sapiens]",2,4,5,4,1531,165.7,5.24,8.46,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFAT5","ENSG00000102908","Cancer immunotherapy by PD-1 blockade","","",372.8,370.4,370.2,384.6,382,405.2,0.950162143710531,-0.07375436674211423,0.05784225975400579,1.2377547485709857,0.16708559532344697,0.7770609896110756,2703]
["High","O94919","endonuclease domain-containing 1 protein [OS=Homo sapiens]",21,6,10,6,500,55,5.71,10.9,"other metabolic processes","non-structural extracellular;cytosol","nucleic acid binding activity;other molecular function","ENDOD1","ENSG00000149218","","Platelet degranulation","",143.1,133.4,142.9,138.4,131.8,140.9,1.0201897348576987,0.028837489532654928,0.5457443069057765,0.2630107860673846,0.7047918538406057,0.15193912425054756,6046]
["High","O94921-1","Cyclin-dependent kinase 14 [OS=Homo sapiens]",4,2,3,1,469,53,8.92,4.72,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CDK14","ENSCATG00000032271; ENSCSAG00000012501; ENSG00000058091; ENSGGOG00000003585; ENSMLEG00000038830; ENSMNEG00000032203; ENSPANG00000022338","","","Transcriptional misregulation in cancer",16.1,17.1,18.9,26.2,16.7,21.9,0.8040123456790125,-0.31471044060611625,0.213720031823587,0.6701547698213083,0.39162778889428945,0.4071264993631261,4261]
["High","O94923","D-glucuronyl C5-epimerase [OS=Homo sapiens]",2,1,2,1,617,70.1,8.97,0,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GLCE","ENSG00000138604","","HS-GAG biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",40,41.3,38.9,24.2,29,24.9,1.5390524967989756,0.622042442569206,1.0479893856253945E-3,2.979643116004644,0.021533424007797577,1.6668869079628186,380]
["High","O94925-1","Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",27,17,56,1,669,73.4,7.77,116.85,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","GLS","ENSG00000115419; ENSGGOG00000007590; ENSPTRG00000012747","Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling","Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer",65.5,53.4,72.2,40.8,38.3,39.9,1.6058823529411768,0.6833662047821509,0.012343274183357858,1.9085696238397718,0.06763248057800572,1.1698446835256655,1425]
["High","O94925-3","Isoform 3 of Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",36,19,69,3,598,65.4,7.88,154.85,"","","","GLS","","","","",2971.4,2930.8,3005.4,2717.2,2686.9,2851.2,1.0790159049338004,0.1097161306276021,0.016663013026011763,1.778246466179071,0.07996607603386592,1.0970942144572944,1627]
["High","O94927","HAUS augmin-like complex subunit 5 [OS=Homo sapiens]",8,4,6,4,633,71.6,8.51,17.88,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","","HAUS5","ENSG00000249115","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",205.2,211.8,193.4,208.5,209.5,215.6,0.9633838383838383,-0.05381737324507922,0.2547529246540072,0.5938808214380981,0.43774446208153345,0.35877933948242513,4544]
["High","O94941-1","RING finger protein 37 [OS=Homo sapiens]",3,1,4,1,541,58.9,7.56,12.27,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","UBOX5","ENSG00000185019","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",65.9,68.6,72.8,68.9,62.4,73.4,1.0127015144113338,0.01820901408600432,0.8295262072060716,0.08116988876536967,0.9030870922845798,0.04427036499687955,7172]
["High","O94952-1","Isoform 2 of F-box only protein 21 [OS=Homo sapiens]",12,6,7,6,621,71.4,6.01,18.46,"","","","FBXO21","","","","",359.7,432,389.4,276.4,355.3,303,1.2636139937948005,0.3375558192998074,0.058356227516247375,1.2339127911759902,0.16825901936737797,0.7740216465304615,2708]
["High","O94953","lysine-specific demethylase 4B [OS=Homo sapiens]",17,12,19,12,1096,121.8,7.09,55.62,"cell organization and biogenesis;protein metabolism;other metabolic processes","nucleus","other molecular function","KDM4B","ENSG00000127663","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Estrogen-dependent gene expression; HDMs demethylate histones","",972.4,980.7,1046.8,957.2,877,965.8,1.071392857142857,0.09948758291470292,0.14436041647250922,0.840551873693081,0.30357288764270185,0.5177370182606045,3713]
["High","O94964-2","Isoform 2 of Protein SOGA1 [OS=Homo sapiens]",11,17,21,14,1661,183.7,6.52,48.57,"","","","SOGA1","","","","",753.4,791.9,814.5,917.5,873.1,877.1,0.8845822243880498,-0.17693184320570512,0.010787795190751424,1.9670673073406555,0.06361865925180296,1.1964154877857012,1324]
["High","O94966-6","Isoform 6 of Ubiquitin carboxyl-terminal hydrolase 19 [OS=Homo sapiens]",18,15,26,15,1384,151.8,6.42,56.32,"","","","USP19","","","","",767.4,705.4,724.1,770.9,721.1,705.1,0.9999089709162078,-1.3133318542415866E-4,0.9981490149919022,8.0461747248282336E-4,0.999429021423028,2.4804366581435041E-4,7798]
["High","O94967-1","WD repeat-containing protein 47 [OS=Homo sapiens]",3,3,4,3,919,101.9,5.94,7.7,"","cytoskeleton;other cell component","","WDR47","ENSG00000085433","","","",230.6,255.6,242.2,196.9,226.1,212.3,1.1465449393987093,0.19729290317605,0.04907104931754393,1.309174655123901,0.15168121657616113,0.8190681966845774,2526]
["High","O94973","AP-2 complex subunit alpha-2 [OS=Homo sapiens]",28,21,51,12,939,103.9,6.96,100.25,"transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","AP2A2","ENSG00000183020","Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission","Neutrophil degranulation; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; Potential therapeutics for SARS; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease",950.2,1007.6,951.6,891.6,963.9,937.4,1.0417129148913316,0.05895774083268312,0.24251681209532608,0.6152581492384414,0.4246627649339103,0.3719558169294132,4459]
["High","O94979","Protein transport protein Sec31A [OS=Homo sapiens]",21,23,58,23,1220,132.9,6.89,119.61,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC31A","ENSG00000138674","Sterol regulatory element-binding proteins (SREBP) signaling","COPII-mediated vesicle transport; Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; XBP1(S) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum",2784.8,2850.4,2687.7,2404.2,2639.6,2585.2,1.0909555642941413,0.12559234045341985,0.053658415762170966,1.2703621538016847,0.15954490109330957,0.7971170708965098,2626]
["Low","O94983","Calmodulin-binding transcription activator 2 [OS=Homo sapiens]",1,1,1,1,1202,131.4,7.3,0,"stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CAMTA2","ENSG00000108509","","","",24.6,35.3,31.7,27.3,30.1,25.8,1.1009615384615383,0.1387640699558516,0.45482118804901606,0.3421593117098296,0.6324566048596113,0.1989692676486708,5615]
["High","O94985-1","Calsyntenin-1 [OS=Homo sapiens]",1,1,2,1,981,109.7,4.91,2.37,"cell adhesion;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CLSTN1","ENSG00000171603","Splicing factor NOVA regulated synaptic proteins","","",34.4,38.7,41.5,42.7,42.5,41.3,0.9059288537549407,-0.14253034082476765,0.13336719038441142,0.874950997912422,0.2899835763078486,0.5376265983798597,3591]
["High","O94986-1","Isoform 1 of Centrosomal protein of 152 kDa [OS=Homo sapiens]",5,4,4,4,1275,147.3,5.43,4.51,"","","","CEP152","","","","",46.8,38.9,53.8,38.7,39.1,40.5,1.1792054099746407,0.23781504837676148,0.17866793432178038,0.7479533836817368,0.3490215739765977,0.4571477272832063,3997]
["High","O94992","Protein HEXIM1 [OS=Homo sapiens]",13,4,5,4,359,40.6,4.89,3.94,"stress response;developmental processes;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","HEXIM1","ENSG00000186834","Initiation of transcription and translation elongation at the HIV-1 LTR","","",191.1,202.3,172.4,400.8,219.9,171.1,0.7145743874715837,-0.4848438906338439,0.34492302692850124,0.46227781133234214,0.5311950679009344,0.2747459660070427,5070]
["High","O95049-1","Tight junction protein ZO-3 [OS=Homo sapiens]",3,2,2,2,919,101.3,6.76,5.46,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","TJP3","ENSG00000105289","1q21.1 copy number variation syndrome","","Tight junction",68.3,64.1,80,89.8,80.4,89.3,0.8184971098265895,-0.2889507724410897,0.049950148679179504,1.3014632147362746,0.15318568770111293,0.8147818093952758,2546]
["High","O95057","GTP-binding protein Di-Ras1 [OS=Homo sapiens]",11,2,2,2,198,22.3,8.72,5.66,"signal transduction","plasma membrane;other membranes","other molecular function","DIRAS1","ENSG00000176490","","","",106.3,80.5,76.5,103.7,92.6,92.4,0.9120193972982333,-0.13286358618991928,0.44725602868328046,0.3494437967500005,0.6270739938874221,0.20268120998112413,5569]
["High","O95059","Ribonuclease P protein subunit p14 [OS=Homo sapiens]",16,1,2,1,124,13.7,7.75,3.51,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP14","ENSG00000163684","","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","",12.1,12.4,12.9,10.9,18,14.8,0.8558352402745995,-0.22459500961296186,0.3669203973939707,0.43542814480055986,0.5508391584026385,0.2589751939167566,5201]
["High","O95067","G2/mitotic-specific cyclin-B2 [OS=Homo sapiens]",26,8,14,8,398,45.3,8.9,33.23,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","CCNB2","ENSG00000157456","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response","Resolution of Sister Chromatid Cohesion; Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint","FoxO signaling pathway; Cell cycle; Oocyte meiosis; p53 signaling pathway; Cellular senescence; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection",730.4,880.3,836.5,657.5,732.3,703.8,1.168895682078716,0.22514618251016755,0.07609999961651565,1.118615345417931,0.2011471892368836,0.6964860317352263,2954]
["High","O95071","E3 ubiquitin-protein ligase UBR5 [OS=Homo sapiens]",18,35,63,35,2799,309.2,5.85,149.28,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBR5","ENSG00000104517","Mesodermal commitment pathway","","Ubiquitin mediated proteolysis",2187.6,2200.6,2191.3,2257.1,2340.5,2335.7,0.9489709085139832,-0.07556423396965685,0.01246499935277754,1.9043077397101595,0.06782349473622791,1.1686198361215352,1435]
["High","O95104","Splicing factor, arginine/serine-rich 15 [OS=Homo sapiens]",20,22,77,19,1147,125.8,9.55,162.91,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SCAF4","ENSG00000156304","","","",3186.4,3284,3308.6,3268.7,3307.3,3292.8,0.9909006160830091,-0.013187727560604759,0.48532230031255214,0.3139697526159435,0.6583385199514258,0.18155073322187576,5756]
["High","O95125","Zinc finger protein 202 [OS=Homo sapiens]",3,2,4,1,648,74.7,5.97,8.5,"other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF202","ENSG00000166261","","Generic Transcription Pathway","",82.2,86.6,80.7,84.8,93.5,89.5,0.9316654219566841,-0.10211614509968762,0.11829340897915464,0.9270394525295166,0.2681866833069801,0.5715627906524984,3444]
["High","O95139","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [OS=Homo sapiens]",20,2,4,2,128,15.5,9.63,9.65,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB6","ENSG00000165264","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",67.2,58.4,50.1,53.6,40.1,58.7,1.1528871391076114,0.20525128851505392,0.3547283120948021,0.4501041475984097,0.540327479679324,0.2673429447879995,5126]
["High","O95140","Mitofusin-2 [OS=Homo sapiens]",17,11,15,11,757,86.3,6.98,31.41,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion","other molecular function","MFN2","ENSG00000116688","Intracellular trafficking proteins involved in CMT neuropathy","Factors involved in megakaryocyte development and platelet production; PINK1-PRKN Mediated Mitophagy; RHOT2 GTPase cycle","Mitophagy; NOD-like receptor signaling pathway; Parkinson disease; Pathways of neurodegeneration",564.2,575.6,561.7,492.6,553.4,520.6,1.086110047236053,0.11917028781837323,0.0677244557098087,1.1692544766333177,0.18626014448122097,0.7298800645005397,2839]
["High","O95149","Snurportin-1 [OS=Homo sapiens]",8,3,5,3,360,41.1,6.64,11.4,"transport","cytosol;nucleus","nucleic acid binding activity;other molecular function","SNUPN","ENSG00000169371","","snRNP Assembly","Nucleocytoplasmic transport",373.1,389.3,393.9,419.4,466.9,440.7,0.8713639788997741,-0.1986526196154424,0.019700651278617403,1.7055194163747325,0.08769822416387953,1.0570092007461187,1754]
["High","O95155","Ubiquitin conjugation factor E4 B [OS=Homo sapiens]",26,26,68,24,1302,146.1,6.55,144.91,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","UBE4B","ENSG00000130939","","","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",2405.4,2444.3,2424.3,2469,2533.5,2471.8,0.9732015038197558,-0.03918954531423863,0.048884264747819074,1.3108309125108066,0.15128352721005603,0.8202083583697458,2523]
["High","O95159","Zinc finger protein-like 1 [OS=Homo sapiens]",19,4,10,4,310,34.1,8.07,28.64,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","ZFPL1","ENSG00000162300","","","",640.6,737.4,735.2,750.2,733.5,744.8,0.9482611622167376,-0.07664364594765227,0.29967319136685894,0.5233521071117685,0.4862527593916115,0.3131379211209403,4812]
["High","O95163","Elongator complex protein 1 [OS=Homo sapiens]",27,25,68,25,1332,150.2,5.94,159.43,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","ELP1","ENSG00000070061","","HATs acetylate histones","",2118.9,2167.5,2108.3,2154.8,2329.8,2274.4,0.9461014943038911,-0.07993313597952613,0.0908619349185212,1.0416180190568407,0.22493658460488697,0.6479399033910893,3154]
["High","O95166","Gamma-aminobutyric acid receptor-associated protein [OS=Homo sapiens]",12,2,4,1,117,13.9,8.79,3.78,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAP","ENSG00000170296","","Macroautophagy; TBC/RABGAPs","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse",231,180.1,243.7,273.4,210.9,213.7,0.9381088825214899,-0.09217271462286118,0.6360476077413733,0.1965103764811918,0.7712781054891509,0.11278899691468063,6439]
["High","O95169","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [OS=Homo sapiens]",18,3,8,3,186,21.8,6.8,10.96,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;ER/Golgi","transporter activity","NDUFB8","ENSG00000166136","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Mitochondrial protein import; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",409.8,432.5,433.3,413.8,405.8,419.7,1.029290728637134,0.041650536674984556,0.2363421063811398,0.6264588981732581,0.41721889365225856,0.3796360328842264,4423]
["Low","O95183","vesicle-associated membrane protein 5 [OS=Homo sapiens]",6,1,1,1,116,12.8,7.85,2.25,"transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP5","ENSG00000168899","","","SNARE interactions in vesicular transport",141.2,146.1,139.1,116.2,112.7,125.5,1.2031602708803613,0.26682883420415765,0.005251385051281816,2.2797261364423305,0.04423173083107705,1.3542660659281922,927]
["High","O95197","Reticulon-3 [OS=Homo sapiens]",4,4,12,3,1032,112.5,4.96,24.88,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","RTN3","ENSG00000133318","Alzheimer's disease and miRNA effects; Alzheimer's disease","Synaptic adhesion-like molecules","Alzheimer disease",775.9,863.8,836.7,715.8,819.4,833.5,1.045467978215899,0.0641488740971594,0.47245123531274247,0.32564301112830557,0.6475161041463741,0.18874942592635016,5697]
["High","O95202-1","mitochondrial proton/calcium exchanger protein [OS=Homo sapiens]",41,30,98,30,739,83.3,6.7,215.37,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;translation activity;other molecular function","LETM1","ENSG00000168924","","RHOG GTPase cycle; Mitochondrial calcium ion transport","",4500.2,4168.2,4467,4553.5,4254,4415.7,0.9933601548793028,-0.009611215548197376,0.8407305689069657,0.07534316137758608,0.9086966060389796,0.04158109402440004,7224]
["High","O95208-1","epsin-2 [OS=Homo sapiens]",7,4,5,4,641,68.4,7.52,11.18,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","EPN2","ENSG00000072134","","Cargo recognition for clathrin-mediated endocytosis","Endocytosis",237.7,232.5,248.9,215.4,215.3,201.5,1.1374565011072446,0.18581137446579074,0.012337893504104417,1.9087589827368283,0.06769801298668116,1.1694240781624772,1423]
["High","O95210","Starch-binding domain-containing protein 1 [OS=Homo sapiens]",4,2,2,2,358,39,5.73,4.4,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STBD1","ENSG00000118804","Exercise-induced circadian regulation","Neutrophil degranulation; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","",144.8,150.8,153.7,159.3,159.7,147,0.9641630901287553,-0.052650893018204324,0.3214206748700222,0.49292619137734384,0.5085415662381223,0.29367354372436394,4935]
["High","O95218-1","Zinc finger Ran-binding domain-containing protein 2 [OS=Homo sapiens]",42,19,63,19,330,37.4,10.01,123.1,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRANB2","ENSANAG00000018241; ENSCANG00000036472; ENSCATG00000025001; ENSG00000132485; ENSGGOG00000023501; ENSMFAG00000003326; ENSMLEG00000036639; ENSMNEG00000042080; ENSNLEG00000009455; ENSPANG00000013398; ENSPPAG00000037049; ENSPTRG00000000856; ENSSBOG00000013268","","","",2568.5,2693.9,2768.7,3516.6,3316.7,3410,0.7840344420255192,-0.3510110626795426,8.5181217821583507E-4,3.0696561551825226,0.019853580559729075,1.7021611575607323,335]
["High","O95219","sorting nexin-4 [OS=Homo sapiens]",26,9,22,9,450,51.9,5.99,41.35,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX4","ENSG00000114520","","","Endocytosis",722.8,752.4,738,788.6,781,754.3,0.9523645595765738,-0.0704141604135751,0.05184149283808523,1.2853225009258897,0.15652682756371597,0.8054112168116295,2586]
["High","O95229","ZW10 interactor [OS=Homo sapiens]",12,3,4,3,277,31.3,5.15,8.19,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","ZWINT","ENSG00000122952","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",183.2,198.8,182.2,169.8,138.3,148.9,1.2345733041575493,0.30401250064013946,0.028858795802629983,1.5397217947665698,0.1092241772307004,0.9616812180810859,2063]
["High","O95232-1","Luc7-like protein 3 [OS=Homo sapiens]",50,23,92,23,432,51.4,9.79,185.6,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","LUC7L3","ENSCANG00000028098; ENSCATG00000034891; ENSG00000108848; ENSGGOG00000024399; ENSMLEG00000034172; ENSMMUG00000010117; ENSPPAG00000025115; ENSPTRG00000009409; ENSRROG00000039925","","","",5543.6,5146.1,5540.3,5538.8,5307.7,5487.4,0.9936389961980912,-0.00920630043765648,0.8280542798360642,0.08194119381822056,0.902239438593356,0.04467819298967694,7166]
["High","O95235","kinesin-like protein KIF20A [OS=Homo sapiens]",20,15,33,15,890,100.2,6.92,63.4,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF20A","ENSG00000112984","","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Mitotic Telophase/Cytokinesis","",1164.4,1133.6,1106,971.8,978.6,949,1.1740360074498173,0.23147665629520917,9.1645324801810119E-4,3.037889685252387,0.020444762744358098,1.6894179249440273,350]
["High","O95237","lecithin retinol acyltransferase [OS=Homo sapiens]",23,4,9,4,230,25.7,7.46,16.73,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LRAT","ENSG00000121207","Vitamin A and carotenoid metabolism","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events","Retinol metabolism; Metabolic pathways; Vitamin digestion and absorption",468.6,446.7,467.5,293.6,299.7,306.4,1.5369567633655665,0.6200765806725024,3.6412640320495021E-5,4.438747828754959,0.005574703835733826,2.25377820019426,51]
["High","O95239-1","Chromosome-associated kinesin KIF4A [OS=Homo sapiens]",48,55,162,55,1232,139.8,6.27,329.66,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","KIF4A","ENSG00000090889; ENSGGOG00000006631; ENSPTRG00000021996","Retinoblastoma gene in cancer","MHC class II antigen presentation; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",7325.3,7248,7295.8,6658,6389.5,6713.3,1.1066910246548722,0.14625249455170367,0.002369482936949572,2.6253464143818945,0.03058003763917729,1.514561984375728,605]
["High","O95243-2","Isoform 2 of Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",9,5,6,5,574,65.3,8.84,2.68,"","","","MBD4","","","","",210.8,233.6,217,212.8,211.7,205.5,1.0498412698412698,0.07017121691647357,0.21841330025708933,0.6607209188409873,0.39705961546154916,0.4011442823496129,4295]
["High","O95248-1","Myotubularin-related protein 5 [OS=Homo sapiens]",4,6,7,6,1867,208.2,6.9,14.6,"","","","","","","","",264.6,261.7,282,252.5,268.1,233.1,1.0724426164256335,0.10090045498544153,0.20224729758542964,0.6941172726901117,0.3777863396045537,0.4227537498065115,4180]
["High","O95249-1","Golgi SNAP receptor complex member 1 [OS=Homo sapiens]",27,8,14,8,250,28.6,9.42,28.62,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","GOSR1","ENSG00000108587","","Intra-Golgi traffic; COPI-mediated anterograde transport","SNARE interactions in vesicular transport",635.4,647.4,620.1,700,635.7,618.8,0.9735993860322334,-0.03859983662262677,0.5439413610319865,0.26444791639167486,0.7035107084541579,0.1527292875865124,6037]
["High","O95251-1","Histone acetyltransferase KAT7 [OS=Homo sapiens]",17,11,25,11,611,70.6,8.85,39.46,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KAT7","ENSAMEG00000012243; ENSANAG00000032052; ENSCANG00000040077; ENSCATG00000030056; ENSCJAG00000007037; ENSDLEG00000005028; ENSECAG00000010150; ENSG00000136504; ENSGGOG00000007469; ENSMLEG00000043692; ENSMNEG00000044419; ENSPANG00000022824; ENSPCTG00005022544; ENSPPAG00000041097; ENSPPYG00000008925; ENSPTRG00000009383; ENSRFEG00010021504","Androgen receptor signaling pathway; Androgen receptor signaling pathway","HATs acetylate histones","",956,919,895.1,976.4,1062.2,1064.2,0.892774268402733,-0.16363264857011026,0.030835383600771666,1.5109506444595953,0.11362089436282452,0.9445417965117544,2119]
["Low","O95259","Potassium voltage-gated channel subfamily H member 1 [OS=Homo sapiens]",1,1,1,1,989,111.4,7.58,1.63,"transport;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","KCNH1","ENSG00000143473","","Voltage gated Potassium channels","",63.9,59.5,52.1,43.8,67.7,58,1.0353982300884956,0.050185757168216896,0.8090199644444147,0.09204076103165726,0.8906976709506472,0.05026968330190205,7092]
["High","O95260-2","Isoform ATE1-2 of Arginyl-tRNA--protein transferase 1 [OS=Homo sapiens]",22,7,9,7,518,59,7.02,16.14,"","","","ATE1","","","","",193.2,200.4,198,242.3,241.5,231.2,0.8274125874125875,-0.27332118945404626,5.8373220544391394E-4,3.233786345304301,0.017070341049086443,1.767757802010241,267]
["High","O95271","Tankyrase-1 [OS=Homo sapiens]",1,2,3,2,1327,142,7.05,4.3,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","TNKS","ENSG00000173273","NAD+ biosynthetic pathways; Regulation of Wnt / B-catenin signaling by small molecule compounds","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; XAV939 stabilizes AXIN","",75.7,72.7,79.2,77.1,92.4,77.3,{"$f":"AVERAGE(T834:V834)/AVERAGE(W834:Y834)","v":0.9222042139384118},{"$f":"LOG(Z834,2)","v":-0.11684183684283579},{"$f":"TTEST(T834:V834,W834:Y834,2,2)","v":0.30184790938145206},{"$f":"-LOG10(AB834)","v":0.5202118277523448},{"$f":"AB834*7808/AF834","v":0.48836064576261456},{"$f":"-LOG10(AD834)","v":0.3112593406664764},4826]
["High","O95273-1","Cyclin-D1-binding protein 1 [OS=Homo sapiens]",9,4,10,4,360,40.2,4.82,21.8,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","","CCNDBP1","ENSG00000166946","","","",849.5,884.3,827.5,670.2,635.1,635.8,1.3195095564370718,0.4000017992996086,5.127392305238485E-4,3.2901034527015445,0.01620837211307777,1.7902606013025746,247]
["High","O95292","Vesicle-associated membrane protein-associated protein B/C [OS=Homo sapiens]",48,11,35,10,243,27.2,7.3,61.69,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAPB","ENSG00000124164","Ciliary landscape","RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle; Sphingolipid de novo biosynthesis","Cholesterol metabolism; Amyotrophic lateral sclerosis; Pathways of neurodegeneration",1592.1,1901.2,1884.9,2107.3,2035.8,1891.1,0.8912863345596765,-0.16603910860930843,0.13966734688810203,0.8549051166051824,0.2975505169174081,0.5264392909236938,3665]
["Medium","O95294-1","RasGAP-activating-like protein 1 [OS=Homo sapiens]",1,1,1,1,804,90,6.51,0,"signal transduction;other biological processes","cytosol","enzyme regulator activity;other molecular function","RASAL1","ENSG00000111344","Ras signaling","Regulation of RAS by GAPs","Ras signaling pathway",9.4,16.7,8.8,15.3,15.1,16.3,0.7473233404710921,-0.4201955135000098,0.20011342462818904,0.6987237756997278,0.37550723852364815,0.42538168683403976,4161]
["High","O95295","SNARE-associated protein Snapin [OS=Homo sapiens]",14,2,4,2,136,14.9,9.31,7.34,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SNAPIN","ENSG00000143553","","Golgi Associated Vesicle Biogenesis","",127.9,96,131.9,86.7,72.1,77.8,1.503803888419273,0.5886164369273714,0.03060542339917731,1.5142016080401595,0.11330827211985606,0.9457383831210104,2109]
["High","O95297-1","Myelin protein zero-like protein 1 [OS=Homo sapiens]",13,3,6,3,269,29.1,8.72,11.85,"cell-cell signaling;signal transduction","plasma membrane;other membranes","other molecular function","MPZL1","ENSG00000197965","","","Cell adhesion molecules",168.7,151.7,166.9,224.5,192.4,215.4,0.7706784754072433,-0.37579899698168034,0.011631289720377622,1.9343721264247717,0.06600080678539859,1.180450755665629,1376]
["High","O95298-1","NADH dehydrogenase [ubiquinone] 1 subunit C2 [OS=Homo sapiens]",24,4,14,4,119,14.2,8.98,25.51,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","NDUFC2","ENSG00000151366; ENSGGOG00000041901","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Neutrophil degranulation; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",1033.6,1017.5,1135.4,826.7,979.9,968.8,1.1481227931109033,0.19927694823176634,0.09016421952525677,1.0449657722763317,0.22434742704053692,0.6490789068686141,3138]
["High","O95299","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [OS=Homo sapiens]",22,7,18,7,355,40.7,8.48,37.43,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity","NDUFA10","ENSG00000130414","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",890.2,971.1,905.8,883.9,964.7,927.4,0.9967939481268012,-0.004632785588405357,0.9347505669267205,0.02930426277382653,0.9656698103418674,0.015171345696186849,7558]
["High","O95302","Peptidyl-prolyl cis-trans isomerase FKBP9 [OS=Homo sapiens]",7,5,8,4,570,63,5.08,9.64,"protein metabolism;other metabolic processes;other biological processes","ER/Golgi","other molecular function","FKBP9","ENSG00000122642","","Association of TriC/CCT with target proteins during biosynthesis","",265.6,228.9,265.9,293.1,258,268.5,0.9277696437286481,-0.10816145236269459,0.2874446824629606,0.5414457211051671,0.47379524607785445,0.3244093011744884,4737]
["High","O95336","6-phosphogluconolactonase [OS=Homo sapiens]",52,10,57,10,258,27.5,6.05,133.7,"other metabolic processes","cytosol;other cell component","other molecular function","PGLS","ENSG00000130313","Pentose phosphate metabolism","Pentose phosphate pathway","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism",2136.1,2177.8,2226,2114.8,2231.7,2194.6,0.9998165446178777,-2.6469445056543142E-4,0.993051736224405,3.0281249472448434E-3,0.9967538187993514,1.412091777623338E-3,7779]
["High","O95340","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [OS=Homo sapiens]",16,9,11,8,614,69.5,8.03,20.58,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS2","ENSG00000198682","RANKL/RANK signaling pathway; Proteoglycan biosynthesis; Sulfation biotransformation reaction","Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Defective PAPSS2 causes SEMD-PA","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways",497.3,488.5,476.6,503.3,510.2,512.7,0.9581968287249378,-0.06160605619307453,0.03256988230648948,1.4871838107852813,0.11773409307827308,0.9290977572775767,2160]
["High","O95347-1","structural maintenance of chromosomes protein 2 [OS=Homo sapiens]",51,64,194,64,1197,135.6,8.43,396.49,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC2; SMC2L1","ENSG00000136824","Retinoblastoma gene in cancer","Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes","",8678.3,8540.9,8580.2,9143.2,9029.4,9191.8,0.9428089050006578,-0.0849627097192905,0.001170091068377724,2.9317803357283934,0.02267015151834558,1.6445455772108672,403]
["High","O95352","Ubiquitin-like modifier-activating enzyme ATG7 [OS=Homo sapiens]",6,4,5,4,703,77.9,6.24,8.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","other molecular function","ATG7","ENSG00000197548","Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy","Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Macroautophagy","Autophagy; Autophagy; Ferroptosis; Neutrophil extracellular trap formation",334.2,348.3,319.8,342.9,338.6,327.7,0.9931629013079665,-0.009897722920174313,0.8185356845973604,0.08696238248795529,0.8953665768193038,0.04799912144896149,7138]
["High","O95359-3","Isoform 3 of Transforming acidic coiled-coil-containing protein 2 [OS=Homo sapiens]",8,15,28,12,2871,300.9,4.78,64.6,"","","","TACC2","","","","",460.4,453.1,462,559.7,498.1,494.1,0.8863328822733423,-0.17407945772133843,0.05154824620155501,1.2877861058982871,0.15636701878078535,0.8058548438080195,2574]
["High","O95363","phenylalanine--tRNA ligase, mitochondrial [OS=Homo sapiens]",8,4,5,4,451,52.3,7.46,10.62,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","FARS2","ENSG00000145982","","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",206.1,226.8,195.9,196.3,228.2,197.8,1.0104451229310623,0.01499097137123249,0.8829053564643945,0.054085848368321573,0.932088294114926,0.03054294619682159,7396]
["High","O95365","Zinc finger and BTB domain-containing protein 7A [OS=Homo sapiens]",4,1,2,1,584,61.4,5.19,7.63,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB7A","ENSG00000178951","IL-18 signaling pathway","","",14.2,13.9,14.9,13.4,13.8,14.8,1.023809523809524,0.03394733192333784,0.5497777662747477,0.25981282756900875,0.7069606059079759,0.15060478579779735,6072]
["High","O95372","acyl-protein thioesterase 2 [OS=Homo sapiens]",29,5,19,5,231,24.7,7.23,45.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;other cell component","other molecular function","LYPLA2","ENSG00000011009","","L1CAM interactions","Glycerophospholipid metabolism",653.3,690.4,692.7,679,649.8,646.8,1.0307754606195585,0.04373009688537518,0.2837833287349627,0.547013121391149,0.46954444389967975,0.32832329407546285,4719]
["High","O95373","Importin-7 [OS=Homo sapiens]",43,36,155,35,1038,119.4,4.82,339.8,"stress response;transport;signal transduction;other biological processes","cytosol;nucleus","transporter activity;enzyme regulator activity;other molecular function","IPO7","ENSG00000205339","","","Nucleocytoplasmic transport",5442,5588.8,5292.6,4995.4,5451,5335,1.0343442280152586,0.048716392040553426,0.325230471293318,0.48780877152018365,0.5120789513729032,0.29066307515265816,4959]
["High","O95376","E3 ubiquitin-protein ligase ARIH2 [OS=Homo sapiens]",31,11,24,11,493,57.8,5.63,55.14,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","ARIH2","ENSG00000177479","Modulators of TCR signaling and T cell activation","Antigen processing: Ubiquitination & Proteasome degradation","",522.7,520.5,481.3,561.3,489.7,563.2,0.9444306777351009,-0.08248318981226536,0.34077992843470345,0.4675259926223458,0.5275197623350841,0.2777612658647544,5044]
["High","O95379","Tumor necrosis factor alpha-induced protein 8 [OS=Homo sapiens]",19,3,6,3,198,23,7.93,13.26,"other biological processes","nucleus;other cell component","enzyme regulator activity","TNFAIP8","ENSG00000145779","","PI Metabolism","",88.6,74.6,97.5,86.2,85.2,89.5,0.9992334227673438,-1.1063612818956762E-3,0.992636937446767,3.2095681162947844E-3,0.9965937003451661,1.4818624127837887E-3,7777]
["High","O95391","Pre-mRNA-splicing factor SLU7 [OS=Homo sapiens]",11,4,5,4,586,68.3,7.14,8.18,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLU7","ENSG00000164609","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","Spliceosome",82.4,64.9,68.4,69.6,76,70.5,0.9981490050902361,-0.002672895699053189,0.9824835747592477,0.007674701462510872,0.9918841158159046,3.5390645409221276E-3,7734]
["High","O95394","phosphoacetylglucosamine mutase [OS=Homo sapiens]",32,16,28,16,542,59.8,6.25,48.67,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PGM3","ENSG00000013375","Glucuronidation","Synthesis of UDP-N-acetyl-glucosamine","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",1492.6,1671.8,1575.8,1649.7,1996,1772.8,0.8748177539909568,-0.19294559542636747,0.1179006862396729,0.9284836670912056,0.2676071389998157,0.5725023050041003,3440]
["High","O95396","Adenylyltransferase and sulfurtransferase MOCS3 [OS=Homo sapiens]",15,7,12,7,460,49.6,6.21,29.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","MOCS3","ENSG00000124217","","Molybdenum cofactor biosynthesis","Sulfur relay system",335.5,348.9,328.9,371.7,343.1,355.2,0.9470093457943924,-0.0785494315329923,0.13649583558211514,0.8648805985228364,0.2940026163379738,0.5316488047712135,3625]
["High","O95400","CD2 antigen cytoplasmic tail-binding protein 2 [OS=Homo sapiens]",40,7,25,7,341,37.6,4.61,49.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","CD2BP2","ENSG00000169217","mRNA processing; Ciliary landscape","mRNA Splicing - Major Pathway","",680.7,603,666.9,733.5,641,631.4,0.9724313275836282,-0.04033172330031526,0.6718956620934122,0.17269816280217695,0.797046692437764,0.09851623610189629,6582]
["High","O95405-1","Zinc finger FYVE domain-containing protein 9 [OS=Homo sapiens]",2,1,1,1,1425,156.3,5.01,0,"transport;signal transduction","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ZFYVE9","ENSG00000157077","TGF-beta signaling pathway; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling","","Endocytosis; TGF-beta signaling pathway",20.2,18.5,17,29.5,27.6,29,0.6469221835075494,-0.6283359100568122,7.3243455274939358E-4,3.135231175956314,0.01881200324956337,1.7255649549064325,304]
["High","O95409","Zinc finger protein ZIC 2 [OS=Homo sapiens]",6,3,6,2,532,55,8.41,13.67,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZIC2","ENSG00000043355","Mesodermal commitment pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Ciliopathies","","",181.1,151.7,186,156.5,165.6,135.8,1.132998471281939,0.18014591457815196,0.21722268220580862,0.6630948280587966,0.3958167334102576,0.40250584965937813,4285]
["High","O95425","Supervillin [OS=Homo sapiens]",11,16,21,16,2214,247.6,6.98,37.41,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SVIL","ENSG00000197321","","","",505.9,470.5,516,607.3,565.4,576.8,0.8530437267790798,-0.22930839931043176,0.010012990742692792,1.9994361853525806,0.06107924353042603,1.2141063503418137,1280]
["High","O95427","GPI ethanolamine phosphate transferase 1 [OS=Homo sapiens]",2,2,2,2,931,105.7,8.65,4.32,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","PIGN","ENSG00000197563","","Synthesis of glycosylphosphatidylinositol (GPI)","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways",108.4,106.8,120.9,135.7,122.3,133.3,0.8589317659085102,-0.2193845675927923,0.03879461337992108,1.4112285718743474,0.13187128483692806,0.8798497624107381,2297]
["High","O95433","activator of 90 kDa heat shock protein ATPase homolog 1 [OS=Homo sapiens]",71,19,96,19,338,38.3,5.53,234.42,"other biological processes","cytosol;ER/Golgi","other molecular function","AHSA1","ENSG00000100591","T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection","","",4228.9,4197.6,4229.2,4538.1,4497.1,4653.8,0.924516034772445,-0.11322975299063791,2.0090357621511262E-3,2.697012332456997,0.029049168946066656,1.53686628762133,540]
["Medium","O95452","Gap junction beta-6 protein [OS=Homo sapiens]",2,1,1,1,261,30.4,8.51,1.99,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","transporter activity;cytoskeletal activity","GJB6","ENSG00000121742","Calcium regulation in cardiac cells","Gap junction assembly","",74.1,61.1,61,77.9,83.8,76.6,0.8233319345362988,-0.2804539099710322,0.04525501570214581,1.344333280082023,0.14446081872541067,0.8402499281236542,2446]
["High","O95453","poly(A)-specific ribonuclease PARN [OS=Homo sapiens]",16,9,20,9,639,73.4,6.2,38.49,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARN","ENSG00000140694; ENSG00000274829","Lung fibrosis","Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA","RNA degradation",977.6,896.1,882.4,892.4,937.2,943.7,0.9937980023798362,-0.008975452938563097,0.8735684338374554,0.058703067471172585,0.927246102692068,0.03280498337857704,7356]
["High","O95456","Proteasome assembly chaperone 1 [OS=Homo sapiens]",46,10,26,10,288,32.8,7.17,55.54,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","PSMG1","ENSG00000183527","","","",992.7,1122.8,1026,1062.8,1329.7,1216.8,0.8703903804061729,-0.20026548294180344,0.14625957064678896,0.8348757058058233,0.30624691005903143,0.513928284508495,3729]
["Medium","O95460","matrilin-4 [OS=Homo sapiens]",2,1,1,1,622,68.4,6.1,0,"","non-structural extracellular;extracellular matrix","other molecular function","MATN4","ENSG00000124159","","ECM proteoglycans","",63.6,71.8,67.4,77.7,72.4,71.8,0.9139251915277151,-0.12985201519367096,0.10280118775778684,0.9880018675034602,0.2447169737843901,0.6113359065565039,3280]
["High","O95470","sphingosine-1-phosphate lyase 1 [OS=Homo sapiens]",13,7,15,7,568,63.5,9.16,27.09,"other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","SGPL1","ENSG00000166224","Sphingolipid pathway; Kennedy pathway from sphingolipids; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",770.3,759.5,755.5,736.2,740.7,747.2,1.0275167483476462,0.03916190978157302,0.020099258496525163,1.6968199643112303,0.08821529530121892,1.05445610773652,1779]
["High","O95478","Ribosome biogenesis protein NSA2 homolog [OS=Homo sapiens]",24,5,21,5,260,30,10.27,29.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","NSA2","ENSG00000164346","","","",822.6,911.5,835.6,1005.1,1046.5,1039.8,0.8312415087015592,-0.2666603967295964,0.004702989416276852,2.3276259985998133,0.04158657005921818,1.3810468975187464,883]
["High","O95479","GDH/6PGL endoplasmic bifunctional protein [OS=Homo sapiens]",11,8,14,8,791,88.8,7.3,27.85,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","H6PD","ENSG00000049239","Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism","","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism",457.6,498.3,420.4,419.4,442.5,430.9,1.06458849009901,0.09029587362397573,0.3011621580579225,0.5211995994670572,0.48785770334362216,0.3117068330472714,4820]
["High","O95486-1","Protein transport protein Sec24A [OS=Homo sapiens]",8,9,15,9,1093,119.7,7.66,32.26,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi","other molecular function","SEC24A","ENSG00000113615","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",574.4,549.9,526.8,497.4,547,565.2,1.0257828031809144,0.036725290452458446,0.6022182557191393,0.22024608336674412,0.7475548713283052,0.12635692415337765,6290]
["High","O95487-1","Protein transport protein Sec24B [OS=Homo sapiens]",8,9,13,9,1268,137.3,6.67,27.89,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SEC24B","ENSG00000138802","Sterol regulatory element-binding proteins (SREBP) signaling","COPII-mediated vesicle transport; MHC class II antigen presentation; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",392.2,398.6,395.7,429.1,424.3,434.8,0.9210526315789473,-0.11864449649861908,6.7485759845773731E-4,3.170787857877754,0.018424084366286758,1.7346140863481616,286]
["High","O95490-1","Adhesion G protein-coupled receptor L2 [OS=Homo sapiens]",16,16,33,16,1459,163.2,6.43,61.6,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ADGRL2","ENSG00000117114","GPCRs, other; GPCRs, class B secretin-like","","",968.4,1013.9,1012.4,1017.3,929.9,936.5,1.0384922148628497,0.054490400948224084,0.3094905518937099,0.5093526045535809,0.4962016897712704,0.30434176110957983,4870]
["High","O95502","neuronal pentraxin receptor [OS=Homo sapiens]",2,1,2,1,500,52.8,6.21,4.73,"other biological processes","other membranes;other cell component","other molecular function","NPTXR","ENSG00000221890","","","",67.9,52.5,55.2,56.2,38.7,53.2,1.1856853477380147,0.24572120424651028,0.27151386312528375,0.5662079910287023,0.45561578407096837,0.3414012389033343,4653]
["High","O95528","Solute carrier family 2, facilitated glucose transporter member 10 [OS=Homo sapiens]",4,2,2,2,541,56.9,8.59,2.24,"transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC2A10","ENSG00000197496","Nuclear receptors meta-pathway; NRF2 pathway","Cellular hexose transport; Defective SLC2A10 causes arterial tortuosity syndrome (ATS)","",13.8,25.1,26.7,19.9,20.8,21,1.0632090761750408,0.08842532546866617,0.7656091365657807,0.11599289245113745,0.8628574102635126,0.06406096680179228,6928]
["High","O95544","NAD kinase [OS=Homo sapiens]",4,1,2,1,446,49.2,6.47,2.77,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NADK","ENSG00000008130","NAD+ metabolism","Nicotinate metabolism","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors",35.6,32.2,37.3,28.8,45.5,43.1,0.8952299829642251,-0.15966973914787347,0.49179958706647214,0.30821184024721593,0.6632074569628695,0.17835059931601668,5790]
["High","O95551-1","Tyrosyl-DNA phosphodiesterase 2 [OS=Homo sapiens]",23,6,14,6,362,40.9,5.1,33.83,"DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TDP2","ENSG00000111802","Oxidative damage response","Nonhomologous End-Joining (NHEJ)","",434.7,428.8,413.4,513.2,530.2,495.5,0.8297485216713237,-0.26925394097167504,1.8122984625099617E-3,2.7417702779908217,0.02791011123328951,1.5542384326655225,507]
["High","O95562","Vesicle transport protein SFT2B [OS=Homo sapiens]",17,2,3,2,160,17.8,9.13,9.05,"transport","other membranes","","SFT2D2","ENSG00000213064","TYROBP causal network in microglia","","",69.2,73.1,88.3,109.4,96.1,94.4,0.7689229743247751,-0.37908900921696814,0.037114208821990395,1.4304597930368284,0.12816795333131403,0.8922205507235527,2261]
["Medium","O95563","Mitochondrial pyruvate carrier 2 [OS=Homo sapiens]",8,1,1,1,127,14.3,10.43,2,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MPC2","ENSG00000143158","Glycolysis and gluconeogenesis","Pyruvate metabolism","Diabetic cardiomyopathy",36.1,37.9,29.3,22.6,26.8,25.9,1.3718459495351922,0.456118484193131,0.032787783319243896,1.484287943646649,0.11819344974914882,0.9274065912773152,2166]
["Medium","O95568","histidine protein methyltransferase 1 homolog [OS=Homo sapiens]",3,1,1,1,372,42.1,6.76,2.2,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","METTL18","ENSG00000171806","","","",43.5,48.2,47.1,49.5,51.7,51.6,0.9083769633507854,-0.13863697545748763,0.04261985791896458,1.3703880024189194,0.1395871856674813,0.855154448828483,2384]
["High","O95571","Persulfide dioxygenase ETHE1, mitochondrial [OS=Homo sapiens]",12,2,4,2,254,27.9,6.83,12.38,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","ETHE1","ENSG00000105755","","Sulfide oxidation to sulfate","Sulfur metabolism; Metabolic pathways",107.7,119.7,109.8,101.4,81.5,101,1.1877421627333569,0.24822168721769072,0.0779273399118433,1.108310148363991,0.20452325043081424,0.6892573137699239,2975]
["High","O95573","long-chain-fatty-acid--CoA ligase 3 [OS=Homo sapiens]",34,19,75,16,720,80.4,8.38,200.86,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL3","ENSG00000123983","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Ciliary landscape; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway",3914.8,4101.4,4079.2,3942.2,4325.7,4345,0.9589705777418356,-0.060441542414659266,0.2963958201800296,0.5281279251378784,0.48344653519232733,0.31565154796119155,4787]
["High","O95602","DNA-directed RNA polymerase I subunit RPA1 [OS=Homo sapiens]",31,42,105,41,1720,194.7,7.03,243.35,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR1A","ENSG00000068654","Pyrimidine metabolism; Eukaryotic transcription initiation","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase",3810.1,3740.1,3742.8,3870.1,3882.4,3900.6,0.9690983515116149,-0.0452850060914608,0.00810682646665279,2.0911491233169697,0.054240018039095964,1.2656801747037045,1167]
["High","O95613","Pericentrin [OS=Homo sapiens]",12,29,38,29,3336,377.8,5.55,73.09,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton","other molecular function","PCNT","ENSG00000160299","","Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy","",1171,1072.3,1180.8,1280.9,1223.6,1264.8,0.9084180086488208,-0.13857178830224978,0.04076708842208311,1.3896903046718658,0.13591350401350338,0.8667373907495749,2342]
["High","O95619","YEATS domain-containing protein 4 [OS=Homo sapiens]",30,7,12,7,227,26.5,8.41,24.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus","cytoskeletal activity;other molecular function","YEATS4","ENSG00000127337","","HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors","",652.3,641.8,617.5,731.2,729.4,697.6,0.8857381150959132,-0.17504789261007017,5.411163319463585E-3,2.266709358015038,0.04470937904589595,1.349601361865666,945]
["High","O95625","Zinc finger and BTB domain-containing protein 11 [OS=Homo sapiens]",6,6,6,6,1053,119.3,8.66,10.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB11","ENSG00000066422","","","",245.5,253,241.8,236.1,244.6,245.5,1.019416138804737,0.02774309844740704,0.35066689795546613,0.4551052284549378,0.5368641449482902,0.2701355998942387,5100]
["High","O95628-1","CCR4-NOT transcription complex subunit 4 [OS=Homo sapiens]",19,8,15,8,575,63.5,7.03,22.75,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CNOT4","ENSG00000080802","","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",527.9,473.3,432.5,279.2,289.4,273.7,1.7021251335628638,0.7673371022027927,2.1497437834677125E-3,2.6676132982504064,0.02970831763064761,1.5271219414112096,565]
["High","O95630","STAM-binding protein [OS=Homo sapiens]",17,8,15,8,424,48,6.29,30.37,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","STAMBP","ENSG00000124356","EGF/EGFR signaling pathway","Metalloprotease DUBs","Endocytosis",808.6,837.9,853.8,836.1,903.9,829,0.973258077072791,-0.03910568233303415,0.44871320496675077,0.3480311496338329,0.6278768287420053,0.2021255439127763,5580]
["High","O95639","Cleavage and polyadenylation specificity factor subunit 4 [OS=Homo sapiens]",13,3,11,3,269,30.2,8.31,18.7,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CPSF4","ENSG00000160917","mRNA processing","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA surveillance pathway; Influenza A",447.9,490.9,503.9,541.9,515.5,518.7,0.9153607004631684,-0.12758774140627208,0.07780672548424276,1.1089828616934112,0.20427535729017063,0.6897840212207113,2974]
["High","O95671-1","N-acetylserotonin O-methyltransferase-like protein [OS=Homo sapiens]",40,20,61,20,621,68.8,6.07,143.5,"other metabolic processes","cytosol","other molecular function","ASMTL","ENSG00000169093","","","Pyrimidine metabolism; Metabolic pathways",2518.3,2694.1,2608.7,2394.9,2546.6,2453.5,1.0576200135226503,0.08082138257916555,0.10237590738845781,0.9898022359318546,0.2440021626645539,0.6126063243616001,3276]
["High","O95674-1","phosphatidate cytidylyltransferase 2 [OS=Homo sapiens]",28,8,30,8,445,51.4,7.09,76.88,"cell organization and biogenesis;other metabolic processes","other membranes;mitochondrion;ER/Golgi","other molecular function","CDS2","ENSG00000101290","","Synthesis of PG","Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system",819.2,884.9,880.4,844.7,902.7,884.3,0.9820648250180493,-0.02610983649267811,0.5944545439024201,0.22588134892940706,0.741098687336755,0.13012395597207943,6263]
["High","O95684","FGFR1 oncogene partner [OS=Homo sapiens]",29,6,8,6,399,43,4.81,15.09,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","CEP43","ENSG00000213066","Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",145.1,142.3,145.8,113.4,148.7,145.5,1.0628066732090284,0.08787919144251333,0.49296297817420853,0.30718569528338674,0.6638590778862056,0.17792410164373001,5798]
["High","O95696-2","Isoform 2 of Bromodomain-containing protein 1 [OS=Homo sapiens]",10,9,13,9,1189,133.2,8.59,26.54,"","","","BRD1","","","","",542,498.4,549.2,537.7,530.2,550.8,0.9820226107370111,-0.02617185240175535,0.5982494434003316,0.22311769677349214,0.7441662663804028,0.12833002076556752,6277]
["High","O95707","Ribonuclease P protein subunit p29 [OS=Homo sapiens]",6,1,2,1,220,25.4,10.07,3.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP4","ENSG00000105171","","tRNA processing in the nucleus","Ribosome biogenesis in eukaryotes",49.5,40.4,36.4,42.4,42.4,38.1,1.0276647681041498,0.03936972341489066,0.7974752243436641,0.09828280055664106,0.8839702657120002,0.05356234319324496,7044]
["High","O95714","E3 ubiquitin-protein ligase HERC2 [OS=Homo sapiens]",3,14,19,14,4834,526.9,6.28,37.23,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HERC2","ENSG00000128731","Prader-Willi and Angelman syndrome","SUMOylation of DNA damage response and repair proteins; Antigen processing: Ubiquitination & Proteasome degradation; Nonhomologous End-Joining (NHEJ); Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint","Ubiquitin mediated proteolysis",428.8,398.4,415.1,380.7,406.5,386.1,1.0588084888775249,0.0824416666369331,0.12282297394484415,0.9107203911404763,0.27510091238133766,0.5605079692558154,3486]
["High","O95716","ras-related protein Rab-3D [OS=Homo sapiens]",41,8,19,5,219,24.3,4.93,39.34,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3D","ENSG00000105514","","Neutrophil degranulation; RAB geranylgeranylation","Pancreatic secretion",564.1,618.3,545.6,551.1,666.8,576.6,0.9629423237670661,-0.05447870565260879,0.6201158767715379,0.2075271493077823,0.7605819613308463,0.11885397893413122,6366]
["High","O95747","Serine/threonine-protein kinase OSR1 [OS=Homo sapiens]",37,16,61,14,527,58,6.43,137.72,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol","kinase activity;other molecular function","OXSR1","ENSG00000172939","","","",2170.1,2154.4,2196.8,2098.1,2092.5,2054.3,1.044260116254864,0.06248111965587112,0.007608747922867387,2.118686803798141,0.0526676451965856,1.2784560987868288,1128]
["High","O95749","geranylgeranyl pyrophosphate synthase [OS=Homo sapiens]",17,5,9,5,300,34.8,6.14,16.5,"other metabolic processes","cytosol","other molecular function","GGPS1","ENSG00000152904","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Terpenoid backbone biosynthesis; Metabolic pathways",531.1,527.9,504.2,506.3,467.2,486.3,1.0708316207699686,0.09873164630880006,0.0711440362392409,1.1478614994720742,0.19247839049064203,0.7156180215709141,2886]
["High","O95754-1","Semaphorin-4F [OS=Homo sapiens]",2,1,2,1,770,83.5,6.95,5.43,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","SEMA4F","ENSG00000135622","","RND3 GTPase cycle","Axon guidance",55.1,47.1,50.2,22.2,23.3,22.8,{"$f":"AVERAGE(T898:V898)/AVERAGE(W898:Y898)","v":2.231332357247438},{"$f":"LOG(Z898,2)","v":1.1579054192032316},{"$f":"TTEST(T898:V898,W898:Y898,2,2)","v":0.000283103750201715},{"$f":"-LOG10(AB898)","v":3.5480543776107947},{"$f":"AB898*7808/AF898","v":0.013157583818898751},{"$f":"-LOG10(AD898)","v":1.8808238546780223},168]
["High","O95757","Heat shock 70 kDa protein 4L [OS=Homo sapiens]",31,19,58,14,839,94.5,5.88,120.14,"stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","HSPA4L","ENSG00000164070","","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",902.9,932.2,998.2,944.1,954.7,936.1,0.999435606194222,-0.000814478009502564,0.9860601852826637,0.006096576601941664,0.9927992168519715,3.1385740929299765E-3,7755]
["High","O95758-1","Isoform 1 of Polypyrimidine tract-binding protein 3 [OS=Homo sapiens]",9,6,44,2,521,56.5,9.22,71.01,"","","","PTBP3","","","","",175.7,164,147.9,168.6,175.9,151.6,0.9828663575891957,-0.024932831272466174,0.806110652524886,0.09360533973017574,0.8888733194343045,0.05116012945824109,7081]
["High","O95772-1","STARD3 N-terminal-like protein [OS=Homo sapiens]",12,3,5,3,234,26.6,4.81,9.62,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STARD3NL","ENSCANG00000042172; ENSCATG00000036966; ENSCSAG00000015104; ENSG00000010270; ENSGGOG00000013471; ENSMFAG00000043802; ENSMLEG00000030425; ENSMMUG00000023659; ENSMNEG00000034363; ENSPANG00000016262; ENSPPAG00000039214; ENSPTRG00000019094; ENSRBIG00000036179; ENSRROG00000026971","","Pregnenolone biosynthesis","",377.6,396.6,387.6,382.6,378.2,401.1,0.9999139340735004,-1.2417222892613676E-4,0.9971932233877854,1.2206814872481287E-3,0.9991126252036223,0.000385553067795395,7793]
["High","O95777","U6 snRNA-associated Sm-like protein LSm8 [OS=Homo sapiens]",52,3,17,3,96,10.4,4.48,40.09,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","LSM8","ENSG00000128534","","mRNA Splicing - Major Pathway","RNA degradation; Spliceosome",282.8,268.2,273.3,297.2,326,295.6,0.8971484545058771,-0.15658136185172752,0.04296800138185198,1.3668548466656352,0.1401981424109905,0.8532577406204372,2393]
["High","O95782-2","Isoform B of AP-2 complex subunit alpha-1 [OS=Homo sapiens]",40,31,81,22,955,105.3,7.66,182.32,"","","","AP2A1","","","","",3403.5,3412.1,3251.9,2880.4,3086.6,2867.6,1.139553573449845,0.18846875113552972,0.009514434345035273,2.0216170264134554,0.059241390244047384,1.2273747582495176,1254]
["High","O95785-3","Isoform 3 of Protein Wiz [OS=Homo sapiens]",19,12,21,3,965,102.9,9.52,51.56,"","","","WIZ","","","","",441.5,458.9,444.4,482.2,513.4,505.1,0.8961151462650764,-0.15824397167558266,0.00849332345529499,2.0709223361560403,0.055868466334408826,1.2528332504519961,1187]
["High","O95785-4","Isoform 4 of Protein Wiz [OS=Homo sapiens]",19,10,20,1,835,89.3,9.48,51.01,"","","","WIZ","","","","",18.8,13.2,18.8,19.5,11.7,18.6,1.0200803212851408,0.02868275470408527,0.9193160726367702,0.0365351469360067,0.9552861185983367,0.01986653300473711,7514]
["High","O95786","Probable ATP-dependent RNA helicase DDX58 [OS=Homo sapiens]",1,1,1,1,925,106.5,6.4,3.27,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","DDX58","ENSG00000107201","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Pathways of nucleic acid metabolism and innate immune sensing; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation","ISG15 antiviral mechanism; Ub-specific processing proteases; OAS antiviral response; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation","NF-kappa B signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease",43.6,40.2,37.3,44.6,47.3,56.9,0.8138440860215054,-0.29717566141370266,0.09026202224511855,1.0444949407022264,0.22444772920060052,0.648884784116806,3140]
["High","O95789","Zinc finger MYM-type protein 6 [OS=Homo sapiens]",3,3,4,3,1325,148,8.22,0,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZMYM6","ENSG00000163867","","","",160.2,88.8,91.3,23.5,27.7,28.9,4.248439450686642,2.0869330035562985,0.020864898050329168,1.6805837329885842,0.09050729109831675,1.0433164334332548,1800]
["High","O95793","double-stranded RNA-binding protein Staufen homolog 1 [OS=Homo sapiens]",36,18,38,18,577,63.1,9.44,75.33,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","STAU1","ENSG00000124214","","","",2093.6,2045,2200.2,2063.9,1908.4,1873.9,1.0842598611063596,0.11671056425662929,0.09153293585541868,1.038422607720308,0.22595294440692668,0.6459819949773954,3163]
["High","O95801","Tetratricopeptide repeat protein 4 [OS=Homo sapiens]",51,15,50,15,387,44.7,5.6,111.91,"stress response","nucleus;other cell component","other molecular function","TTC4","ENSG00000243725","","","",2354.2,2275.1,2310.1,2433.2,2322.8,2305.4,0.9827229727816015,-0.025143313236349163,0.4275047228135479,0.36905908308660795,0.6087829428648882,0.21553752431145345,5483]
["Medium","O95807","transmembrane protein 50A [OS=Homo sapiens]",6,1,1,1,157,17.4,5.87,2.4,"transport","other membranes;ER/Golgi;other cell component","","TMEM50A","ENSG00000183726","","","",50.9,58.1,48.6,54.7,59.5,62.8,0.8903954802259887,-0.16748182551398355,0.15574636611008388,0.807582077553219,0.31842566812975515,0.4969919312679014,3819]
["High","O95816","BAG family molecular chaperone regulator 2 [OS=Homo sapiens]",37,8,19,8,211,23.8,6.7,30.16,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","BAG2","ENSG00000112208","Malignant pleural mesothelioma","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",810.4,696.3,820.9,868.7,766.6,726.4,0.9855612482533767,-0.02098256374474768,0.8546438615623008,0.06821482232427559,0.9173851073794946,0.03744831438433332,7274]
["High","O95817","BAG family molecular chaperone regulator 3 [OS=Homo sapiens]",2,1,1,1,575,61.6,6.95,2.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BAG3","ENSG00000151929","","Regulation of HSF1-mediated heat shock response","",18.5,16,21.7,34.1,14.5,13.4,0.9064516129032258,-0.1416980850533114,0.7939038295882339,0.10023210312548846,0.8815132396793132,0.05477116053256855,7032]
["High","O95819","Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",18,19,46,1,1239,142,7.46,103.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","cytoskeletal activity;kinase activity;other molecular function","MAP4K4","ENSG00000071054","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma","Oxidative Stress Induced Senescence","MAPK signaling pathway",38.2,30.1,30.4,47.6,34.1,38.5,0.8211314475873545,-0.2843149062547877,0.20803189796525126,0.6818700686517811,0.3849995400124868,0.4145397893750267,4219]
["High","O95819-3","Isoform 3 of Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",17,19,47,1,1320,150.9,7.42,106.24,"","","","MAP4K4","","","","",2173.4,2321.4,2163.7,2326.2,2372.1,2328.5,0.9475863835600844,-0.07767062711491783,0.08211413387876292,1.0855820835961445,0.21201956260759947,0.6736240657666781,3024]
["High","O95822","Malonyl-CoA decarboxylase, mitochondrial [OS=Homo sapiens]",14,5,7,5,493,55,8.95,19.9,"other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","MLYCD","ENSG00000103150","","","beta-Alanine metabolism; Propanoate metabolism; Metabolic pathways; Peroxisome; AMPK signaling pathway; Alcoholic liver disease",282.5,304.2,281,268.5,294.8,300.6,1.004398657251997,0.006332005031110644,0.923545489234215,0.03454170852166779,0.9580235392507972,0.01862381989730536,7527]
["High","O95825-1","Quinone oxidoreductase-like protein 1 [OS=Homo sapiens]",22,6,16,6,349,38.7,5.78,20.08,"other metabolic processes","","other molecular function","CRYZL1","ENSG00000205758","","","",380.8,389.1,383.2,356.1,408.9,398.9,0.9907208523068993,-0.013449477156249896,0.8367972221822012,0.07737977015096936,0.9068303554196567,0.042473950642342086,7205]
["High","O95831-1","Apoptosis-inducing factor 1, mitochondrial [OS=Homo sapiens]",29,16,46,16,613,66.9,8.95,115.94,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","AIFM1","ENSG00000156709","Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70","","Apoptosis; Necroptosis",1824.4,1916.1,1933.4,2075.2,2134.8,2172.2,0.8890194603741656,-0.16971309531710976,5.853600531402197E-3,2.2325769185484927,0.04673303982534597,1.330375968677459,978]
["High","O95834","echinoderm microtubule-associated protein-like 2 [OS=Homo sapiens]",6,4,5,4,649,70.6,6.32,10.72,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","EML2","ENSG00000125746","","","",299,316.3,302.1,322.4,367.8,324.1,0.9044661342797988,-0.14486160953257265,0.11013857812823134,0.9580605344921892,0.256017272410012,0.5917307336752181,3359]
["Medium","O95857","Tetraspanin-13 [OS=Homo sapiens]",4,1,1,1,204,22.1,7.93,1.89,"other biological processes","plasma membrane;other membranes","other molecular function","TSPAN13","ENSG00000106537","","","",97.2,79.2,90.3,98.2,93.9,89.4,0.9474245115452931,-0.07791709741666582,0.4448204206217983,0.3518152835667502,0.6248934588368119,0.20419402134946793,5558]
["High","O95861-1","3'(2'),5'-bisphosphate nucleotidase 1 [OS=Homo sapiens]",47,11,21,11,308,33.4,5.69,35.66,"other metabolic processes;developmental processes","cytosol","other molecular function","BPNT1; HEL20","ENSG00000162813; ENSPTRG00000001996","","Cytosolic sulfonation of small molecules","Sulfur metabolism; Metabolic pathways",784,789.6,781.3,845.5,916.7,844.7,0.9033334611991253,-0.14666944493020392,0.024871886732262403,1.6042912687577813,0.10077825200078093,0.9966331787545989,1927]
["High","O95863","Zinc finger protein SNAI1 [OS=Homo sapiens]",4,1,1,1,264,29.1,8.65,2.92,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SNAI1","ENSG00000124216","Neural crest differentiation; Mesodermal commitment pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Epithelial to mesenchymal transition in colorectal cancer; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; CCL18 signaling pathway","Regulation of PTEN gene transcription","Adherens junction",16.4,14.6,14.7,22.3,15,18.6,0.817531305903399,-0.29065411778512035,0.19497564524389258,0.7100196337490847,0.369238379351034,0.43269316389180784,4123]
["High","O95864","fatty acid desaturase 2 [OS=Homo sapiens]",16,7,10,7,444,52.2,8.82,19.47,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","FADS2","ENSG00000134824","PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis","alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","alpha-Linolenic acid metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway",365.5,410.1,394.3,530.9,549.1,546.5,0.7192745158315402,-0.47538560510865846,4.3402232243186186E-4,3.3624879334836315,0.015061539082435455,1.8221306469363585,225]
["High","O95865","N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [OS=Homo sapiens]",48,10,40,9,285,29.6,6.01,100.42,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion","other molecular function","DDAH2","ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076","Nitric oxide metabolism in cystic fibrosis","eNOS activation","",1351.5,1319.6,1307.6,1307.1,1364.5,1344.3,0.9907368211359846,-0.013426223416501216,0.591891099050299,0.22775819096648847,0.7388466349136267,0.1314457003372918,6255]
["High","O95873","Uncharacterized protein C6orf47 [OS=Homo sapiens]",4,1,1,1,294,31.7,6.37,2.78,"","","","C6orf47","ENSG00000203623; ENSG00000204439; ENSG00000226103; ENSG00000226531; ENSG00000228177; ENSG00000228435; ENSG00000235360","","","",42.4,36,45.4,46.3,48.5,51.7,0.8450511945392493,-0.24288935009534537,0.07632452048295175,1.1173359155227458,0.20153596751129094,0.6956474353902281,2957]
["High","O95881","Thioredoxin domain-containing protein 12 [OS=Homo sapiens]",31,5,18,5,172,19.2,5.4,40.09,"other biological processes","ER/Golgi","other molecular function","TXNDC12","ENSG00000117862","","","Glutathione metabolism; Metabolic pathways",1083.5,1056.4,1142.3,1008.3,921.9,909.8,1.1557042253521126,0.20877222204579213,0.02121104045728005,1.6734380276752052,0.0913490368948939,1.0392960271120784,1813]
["High","O95900","Mitochondrial mRNA pseudouridine synthase TRUB2 [OS=Homo sapiens]",8,3,6,2,331,36.7,8.98,11.66,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","TRUB2","ENSG00000167112","","","",189.7,186.2,209.2,188,196.3,164.8,1.0655618284465487,0.09161430687500492,0.3679289925881241,0.4342359886708273,0.5520348912621201,0.25803347190174053,5204]
["High","O95905","Protein ecdysoneless homolog [OS=Homo sapiens]",21,9,9,9,644,72.7,4.87,11.41,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ECD","ENSG00000122882","","","",221.9,219.3,221.5,300.7,276.7,301.8,0.7537534121929027,-0.40783546687280003,9.322066764748053E-4,3.0304877909702825,0.020619460991261416,1.6857226916994696,353]
["High","O95983-1","methyl-CpG-binding domain protein 3 [OS=Homo sapiens]",29,8,27,8,291,32.8,5.34,30.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MBD3","ENSG00000071655; ENSPTRG00000010209","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; Regulation of TP53 Activity through Acetylation","",881.3,872.1,894.7,939.1,798.9,792.5,1.0464730290456434,0.06553512921089626,0.4624158839731146,0.3349672563275913,0.6397135404078808,0.1940144567512661,5644]
["High","O95985","DNA topoisomerase 3-beta-1 [OS=Homo sapiens]",13,7,11,7,862,96.6,8.12,19.99,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP3B","ENSG00000100038","","","Homologous recombination; Fanconi anemia pathway",290.4,260.2,290.6,284.9,276,287.3,0.9917472294270218,-0.011955632864655516,0.8375877488668666,0.0769696835718455,0.9068060375974063,0.042485596963574464,7212]
["High","O95989","Diphosphoinositol polyphosphate phosphohydrolase 1 [OS=Homo sapiens]",25,3,10,3,172,19.5,6.34,26.94,"cell-cell signaling;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT3","ENSG00000272325","","Synthesis of pyrophosphates in the cytosol","",477.2,551.7,469,477.8,547.6,502.2,0.9805577376276512,-0.028325512571265372,0.7811735073011531,0.1072524937866648,0.8719660822026309,0.05950040795587582,6995]
["High","O95995","Growth arrest-specific protein 8 [OS=Homo sapiens]",4,2,2,2,478,56.3,7.94,2.7,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","GAS8","ENSG00000141013","Ciliopathies","Activation of SMO","",55.9,52.7,48.1,34.2,35.9,35.3,1.486717267552182,0.5721303128353655,1.7991584691963503E-3,2.7449305824762846,0.027817483816802185,1.5556821559363108,505]
["High","O95997","Securin [OS=Homo sapiens]",7,1,1,1,202,22,6.6,2.33,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PTTG1","ENSG00000164611","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition","APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids","Cell cycle; Oocyte meiosis; Human T-cell leukemia virus 1 infection",24.5,23,25.8,27.3,22,20.5,1.0501432664756447,0.07058616192415966,0.6263408673225213,0.20318925064321497,0.7649725468566003,0.116354150418444,6393]
["Medium","O95999","B-cell lymphoma/leukemia 10 [OS=Homo sapiens]",3,1,1,1,233,26.2,5.74,2.26,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BCL10","ENSG00000142867","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling","NF-kappa B signaling pathway; C-type lectin receptor signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway; Shigellosis; Tuberculosis",85.4,77,91.5,97.6,61.8,53.3,1.1937000470145747,0.25544036168683354,0.38853123016406693,0.41057406684296993,0.5722791633882351,0.24239206641076108,5301]
["High","O96000","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [OS=Homo sapiens]",19,3,3,3,172,20.8,8.48,6.91,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB10","ENSG00000140990","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Modulators of TCR signaling and T cell activation; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",74.9,56.7,77.4,69.6,47.9,55.8,1.20600115406809,0.2702312878080753,0.2609553543623757,0.5834337877290903,0.44468341485408763,0.35194906792383357,4582]
["High","O96005-1","Cleft lip and palate transmembrane protein 1 [OS=Homo sapiens]",26,10,31,10,669,76,6.3,69.79,"developmental processes;other biological processes","plasma membrane;other membranes;other cell component","","CLPTM1","ENSG00000104853","","","",992.9,1010.9,1023,903.8,979.8,1029.2,1.0391375995605603,0.05538670434773941,0.3682608481988656,0.43384445088448287,0.5522144618276825,0.2578922239015398,5207]
["High","O96006","zinc finger BED domain-containing protein 1 [OS=Homo sapiens]",10,7,11,7,694,78.1,6.1,24.05,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED1","ENSG00000214717","","SUMOylation of chromatin organization proteins","",481.4,491.9,489.7,613.2,618.8,574,0.810077519379845,-0.3038681233423714,1.3809240652409508E-3,2.859830201909079,0.024786793336554813,1.6057796542050806,435]
["High","O96007","molybdopterin synthase catalytic subunit [OS=Homo sapiens]",23,3,4,3,188,20.9,5.44,8.19,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","MOCS2","ENSG00000164172","","Molybdenum cofactor biosynthesis","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system",270.9,268.9,302.1,253.5,239,276,1.0955107351984383,0.13160362174636092,0.18302932806982783,0.7374793146500855,0.3537358894973306,0.4513208751020551,4040]
["High","O96008","Mitochondrial import receptor subunit TOM40 homolog [OS=Homo sapiens]",45,12,98,12,361,37.9,7.25,220.56,"cell organization and biogenesis;transport","other membranes;cytosol;mitochondrion;other cell component","transporter activity","TOMM40","ENSG00000130204","IL-18 signaling pathway","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",2405.4,3083.4,2716.6,2268.4,2941.6,2735.4,1.032723336773479,0.046453812649857026,0.7718852115024601,0.11244727960944108,0.8676763218271248,0.061642253925549166,6946]
["High","O96011-1","Peroxisomal membrane protein 11B [OS=Homo sapiens]",7,2,3,2,259,28.4,9.85,7.3,"cell organization and biogenesis;signal transduction","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PEX11B","ENSG00000131779; ENSPPAG00000024465; ENSPTRG00000001203","","Class I peroxisomal membrane protein import","Peroxisome",216,218,205,224.3,225.4,229.3,0.9410898379970545,-0.08759564329773738,0.036619333074616296,1.436289569500502,0.1271902814264253,0.8955460717388901,2248]
["High","O96013-1","serine/threonine-protein kinase PAK 4 [OS=Homo sapiens]",12,6,13,6,591,64,9.73,26.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","PAK4","ENSG00000130669","Integrin-mediated cell adhesion; Focal adhesion; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle","ErbB signaling pathway; Ras signaling pathway; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Regulation of actin cytoskeleton; Human immunodeficiency virus 1 infection; MicroRNAs in cancer; Renal cell carcinoma",394.8,375.5,375.5,456.8,399.4,449.1,0.8778058683827471,-0.188026179829488,0.04966305123124154,1.3039666014914186,0.15260492090261077,0.8164314618831525,2541]
["High","O96017-1","Serine/threonine-protein kinase Chk2 [OS=Homo sapiens]",26,11,24,11,543,60.9,5.91,43.01,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","CHEK2","ENSG00000183765","miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection",702.6,715.4,673.1,900.1,968.6,920.3,0.7497669415561133,-0.4154858786298251,6.2092081766578226E-4,3.206963779281389,0.01769397716910375,1.7521745374431417,274]
["High","O96018","amyloid-beta A4 precursor protein-binding family A member 3 [OS=Homo sapiens]",3,2,2,2,575,61.4,4.94,2.99,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","APBA3","ENSG00000011132","","Neurexins and neuroligins","",102,111.7,102.7,90.7,101.6,124.8,0.9977924944812361,-0.003188277631047557,0.9833807840035422,7.2782824021345345E-3,0.9918921536622732,0.00353554520017993,7741]
["High","O96019-1","Actin-like protein 6A [OS=Homo sapiens]",47,18,54,18,429,47.4,5.6,115.33,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","ACTL6A","ENSCANG00000034249; ENSCATG00000017467; ENSCCAG00000029449; ENSCJAG00000013036; ENSCSAG00000013017; ENSG00000136518; ENSGGOG00000015710; ENSMFAG00000030153; ENSMMUG00000009742; ENSPANG00000024431; ENSPPAG00000031814; ENSPTRG00000023973; ENSRBIG00000036584; ENSRROG00000035215","Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; UCH proteinases; HATs acetylate histones; DNA Damage Recognition in GG-NER","Thermogenesis; Hepatocellular carcinoma",3273,2949.9,3158.4,3284.3,3099.5,3214.4,0.9774020128774145,-0.03297601919036141,0.5428544215340705,0.2653166205053132,0.7028034029743031,0.15316614431763065,6031]
["High","O96028-1","Histone-lysine N-methyltransferase NSD2 [OS=Homo sapiens]",17,19,38,19,1365,152.2,8.69,80.41,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD2","ENSG00000109685","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Lysine degradation; Metabolic pathways; Transcriptional misregulation in cancer",1597.2,1592.6,1593.9,1828.4,1795.9,1872.4,0.8702858078483453,-0.20043882513122432,4.3203471158444911E-4,3.364481358638861,0.015127027031620532,1.8202464170283863,223]
["High","P00167-1","Cytochrome b5 [OS=Homo sapiens]",39,4,9,4,134,15.3,4.96,29.2,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","CYB5A","ENSG00000166347; ENSPTRG00000010111","Oxidation by cytochrome P450","Vitamin C (ascorbate) metabolism","",386.7,334.3,376.1,387.6,324.3,333.1,1.0498564593301436,0.07019209020691705,0.532486676540794,0.2736912543252859,0.6944472975497777,0.15836070781233533,5987]
["High","P00338-1","L-lactate dehydrogenase A chain [OS=Homo sapiens]",72,24,204,21,332,36.7,8.27,395.17,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HEL-S-133P; LDHA","ENSG00000134333; ENSG00000288299","Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glycolysis and gluconeogenesis","Pyruvate metabolism","Glycolysis / Gluconeogenesis; Cysteine and methionine metabolism; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer",5993.8,6554.8,6256.8,6096.8,6986.4,6686,0.9512473949375797,-0.07210749719447089,0.35504060537702603,0.44972197459922963,0.5406976880795434,0.26704548738099354,5127]
["High","P00367","Glutamate dehydrogenase 1, mitochondrial [OS=Homo sapiens]",48,24,107,10,558,61.4,7.8,248.82,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","GLUD1","ENSG00000148672","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension","Transcriptional activation of mitochondrial biogenesis; Glutamate and glutamine metabolism","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Nitrogen metabolism; Metabolic pathways; Carbon metabolism; Necroptosis; Proximal tubule bicarbonate reclamation",4404.7,4388.1,4358.2,4488.7,4522.5,4612.7,0.96528894075852,-0.05096724472979393,0.016160813692587983,1.791536776401505,0.0785701328217478,1.104742512685532,1606]
["High","P00374","dihydrofolate reductase [OS=Homo sapiens]",38,6,19,6,187,21.4,7.42,30.46,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;mitochondrion","nucleic acid binding activity;other molecular function","DHFR","ENSG00000228716","Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Ethanol effects on histone modifications; Nucleotide metabolism","G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","One carbon pool by folate; Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance",516.8,529.6,533,640.1,602.8,606.7,0.8539143598615916,-0.22783670747531826,2.164608896896107E-3,2.6646205608642495,0.02965134432800843,1.5279556118781052,570]
["High","P00387","NADH-cytochrome b5 reductase 3 [OS=Homo sapiens]",46,13,43,13,301,34.2,7.59,99.19,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CYB5R3","ENSG00000100243","Oxidation by cytochrome P450","Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism","Amino sugar and nucleotide sugar metabolism",1695.2,1718,1675.5,1539.7,1684.5,1618.8,1.0507330167251705,0.07139613801795089,0.13367939454900563,0.873935530085202,0.2901775681508579,0.5373361632450777,3597]
["High","P00390","Glutathione reductase, mitochondrial [OS=Homo sapiens]",48,18,57,17,522,56.2,8.5,129.23,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","other molecular function","GSR","ENSG00000104687","Glutathione metabolism; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II","","Glutathione metabolism; Metabolic pathways; Thyroid hormone synthesis; Diabetic cardiomyopathy",1855.7,1967.8,1888.4,1934.1,2045.8,2084.6,0.9418583560062659,-0.08641798245096542,0.10406416051529521,0.9826988148736345,0.24652092393914596,0.6081462132400773,3296]
["High","P00403","Cytochrome c oxidase subunit 2 [OS=Homo sapiens]",28,5,19,5,227,25.5,4.82,32.11,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO2","ENSG00000198712","Electron transport chain: OXPHOS system in mitochondria; Endothelin pathways; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly; CCL18 signaling pathway","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",969.4,959,986.5,882.4,893.4,906.6,1.086676110945422,0.11992200222131626,1.8879425538109275E-3,2.7240112245201975,0.028402804354827983,1.5466387777100197,519]
["High","P00441","Superoxide dismutase [Cu-Zn] [OS=Homo sapiens]",92,14,102,14,154,15.9,6.13,283.23,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SOD1","ENSG00000142168","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species","Peroxisome; Longevity regulating pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis",4002.8,3592,3932.4,3800.6,3553.4,3814.9,1.0320801511339524,0.045555014514380134,0.47762754695426113,0.3209106334171552,0.651522691582612,0.1860704538462585,5724]
["High","P00488","Coagulation factor XIII A chain [OS=Homo sapiens]",7,4,7,4,732,83.2,6.09,10.39,"protein metabolism;other metabolic processes;stress response","non-structural extracellular;other cell component","other molecular function","F13A1","ENSG00000124491","Complement system","Platelet degranulation ; Interleukin-4 and Interleukin-13 signaling; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades; Coronavirus disease",1067.8,802.4,728.3,233.4,236,253.1,3.596539792387543,1.8466095662798612,3.7508090791198794E-3,2.425875041419776,0.037594759036929416,1.4248726944337053,779]
["High","P00491","purine nucleoside phosphorylase [OS=Homo sapiens]",83,19,70,19,289,32.1,6.95,202.75,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PNP","ENSG00000198805","VEGFA-VEGFR2 signaling pathway","Neutrophil degranulation; Purine catabolism; Purine salvage","Purine metabolism; Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways",2907,3194.6,2908.5,2672.4,3209.9,2899,1.0260553676562696,0.03710858327234976,0.6979409397717791,0.15618132611097346,0.8167750086537846,0.08789755908202036,6672]
["High","P00492","Hypoxanthine-guanine phosphoribosyltransferase [OS=Homo sapiens]",42,6,24,6,218,24.6,6.68,36.92,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HPRT1","ENSG00000165704","Mesodermal commitment pathway; Nucleotide metabolism","Purine salvage","Purine metabolism; Drug metabolism; Metabolic pathways",274.5,270.2,281.1,318.7,290.7,303.5,0.9045897688684413,-0.14466441605957475,0.02882364834242934,1.5402510493823687,0.10914405735096425,0.961999905671231,2062]
["High","P00505","Aspartate aminotransferase, mitochondrial [OS=Homo sapiens]",53,20,119,20,430,47.5,9.01,261.14,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","other molecular function","GOT2","ENSG00000125166","Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis","Glyoxylate metabolism and glycine degradation; Gluconeogenesis; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Cysteine and methionine metabolism; Arginine and proline metabolism; Tyrosine metabolism; Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Fat digestion and absorption",5194.3,5474.3,5495.7,5472.1,5644.8,5794.4,0.9558283514573093,-0.06517653393592138,0.13785337456926275,0.8605825981554401,0.2950545911833343,0.5300976231531832,3648]
["High","P00519-2","Isoform IB of Tyrosine-protein kinase ABL1 [OS=Homo sapiens]",12,9,13,9,1149,124.9,8.84,29.2,"","","","ABL1","","","","",497.4,529.3,450.1,516,521.1,498.5,0.9617087783276894,-0.05632800720117539,0.4600154103219389,0.337227619393032,0.6374091080379235,0.19558173511652188,5635]
["High","P00533-1","epidermal growth factor receptor [OS=Homo sapiens]",12,9,10,9,1210,134.2,6.68,20.89,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function","EGFR","ENSG00000146648","Androgen receptor signaling pathway; Glioblastoma signaling pathways; AGE/RAGE pathway; Gastric cancer network 2; Spinal cord injury; Aryl hydrocarbon receptor pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Bladder cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; ERK pathway in Huntington's disease; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Extracellular vesicles in the crosstalk of cardiac cells; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Regulatory circuits of the STAT3 signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway","Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF/MAP kinase cascade; Cargo recognition for clathrin-mediated endocytosis; HCMV Early Events; NOTCH3 Activation and Transmission of Signal to the Nucleus; Signaling by ERBB4; SHC1 events in ERBB2 signaling; GRB2 events in ERBB2 signaling; PI3K events in ERBB2 signaling; ERBB2 Regulates Cell Motility; ERBB2 Activates PTK6 Signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Signal transduction by L1; GRB2 events in EGFR signaling; GAB1 signalosome; SHC1 events in EGFR signaling; EGFR downregulation; EGFR interacts with phospholipase C-gamma; Inhibition of Signaling by Overexpressed EGFR; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PLCG1 events in ERBB2 signaling; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; PTK6 promotes HIF1A stabilization; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors; Signaling by ERBB2 ECD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Calcium signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; Endocytosis; PI3K-Akt signaling pathway; Focal adhesion; Adherens junction; Gap junction; JAK-STAT signaling pathway; Regulation of actin cytoskeleton; GnRH signaling pathway; Estrogen signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Epithelial cell signaling in Helicobacter pylori infection; Shigellosis; Hepatitis C; Human cytomegalovirus infection; Human papillomavirus infection; Coronavirus disease; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer",241.9,227.8,233.1,258.4,259.9,286.3,0.8734775043499876,-0.19515754661725399,0.02701580029968403,1.5683821626578762,0.1051542217048519,0.97817328668364,2006]
["High","P00558","phosphoglycerate kinase 1 [OS=Homo sapiens]",78,30,422,25,417,44.6,8.1,981.27,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol","kinase activity;other molecular function","PGK1","ENSG00000102144","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glycolysis and gluconeogenesis","Gluconeogenesis; Glycolysis; Manipulation of host energy metabolism","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway",19480.8,18838.2,19515.7,19444.8,19104.5,19412.6,0.9978054549626564,-3.1695383631724096E-3,0.8712706963799854,0.05984689243268105,0.925688066040948,0.03353533515369283,7349]
["High","P00568","Adenylate kinase isoenzyme 1 [OS=Homo sapiens]",48,9,23,9,194,21.6,8.63,54.93,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK1","ENSG00000106992","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors",1214.3,1186.5,1244.9,1275.1,1262,1287.3,0.9532737161384793,-0.06903757622182914,0.03164443263569766,1.4997026865400633,0.11561990174053689,0.9369674040454974,2137]
["High","P00734","Prothrombin [OS=Homo sapiens]",5,2,5,2,622,70,5.9,5.85,"protein metabolism;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","F2","ENSG00000180210","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; IL1 and megakaryocytes in obesity; Regulation of actin cytoskeleton; Complement and coagulation cascades","Cell surface interactions at the vascular wall; Regulation of Complement cascade; G alpha (q) signalling events; Peptide ligand-binding receptors; Thrombin signalling through proteinase activated receptors (PARs); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Defective F8 cleavage by thrombin; Gamma-carboxylation of protein precursors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Platelet Aggregation (Plug Formation); Defective factor XII causes hereditary angioedema","Phospholipase D signaling pathway; Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Platelet activation; Regulation of actin cytoskeleton; Pathogenic Escherichia coli infection; Coronavirus disease; Pathways in cancer",307.2,235.5,228.5,64.7,62.4,62.2,4.0739566825145275,2.0264306405262564,1.523794065917841E-3,2.8170737220244297,0.02558663240147635,1.591986870255748,465]
["High","P00747","Plasminogen [OS=Homo sapiens]",5,4,13,4,810,90.5,7.24,18.2,"cell organization and biogenesis;protein metabolism;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLG","ENSG00000122194","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; Complement system; Fibrin complement receptor 3 signaling pathway; Complement and coagulation cascades","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by PDGF; Platelet degranulation ; Activation of Matrix Metalloproteinases; Dissolution of Fibrin Clot","Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Staphylococcus aureus infection; Influenza A",1089.7,973.3,922.6,611,672.5,643.3,{"$f":"AVERAGE(T962:V962)/AVERAGE(W962:Y962)","v":1.5495121444882707},{"$f":"LOG(Z962,2)","v":0.6318140622647814},{"$f":"TTEST(T962:V962,W962:Y962,2,2)","v":2.560201166012536E-3},{"$f":"-LOG10(AB962)","v":2.5917259089628506},{"$f":"AB962*7808/AF962","v":0.03143089733368849},{"$f":"-LOG10(AD962)","v":1.502643219952629},636]
["High","P00750-1","Tissue-type plasminogen activator [OS=Homo sapiens]",5,2,2,2,562,62.9,7.8,5.04,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;other molecular function","PLAT","ENSG00000104368","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; NOTCH1 regulation of endothelial cell calcification; Fibrin complement receptor 3 signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Complement and coagulation cascades","Signaling by PDGF; Dissolution of Fibrin Clot","Apelin signaling pathway; Complement and coagulation cascades; Transcriptional misregulation in cancer; Prostate cancer; Fluid shear stress and atherosclerosis",59.3,48.6,60.7,72.1,62.5,67.9,0.8325925925925928,-0.2643173717172668,0.07503261438660351,1.1247499210175889,0.19906716042494063,0.7010003784585642,2943]
["High","P00813","adenosine deaminase [OS=Homo sapiens]",25,6,9,6,363,40.7,5.95,14.19,"cell adhesion;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ADA","ENSG00000196839","","Purine salvage","Purine metabolism; Metabolic pathways; Primary immunodeficiency",400.3,420.6,402.8,430.3,445,414,0.9491196773442955,-0.07533808243003184,0.11773336363311673,0.9291004480443661,0.2674606061237636,0.572740175522956,3437]
["High","P00846","ATP synthase subunit A [OS=Homo sapiens]",4,1,5,1,226,24.8,10.1,12.85,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ATP6","ENSG00000198899","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",316.3,323.4,331.9,262,308.2,326.8,1.0831661092530658,0.11525450482924146,0.27718064907942763,0.5572370925716785,0.46155395777610814,0.3357775206518925,4689]
["High","P00918","Carbonic anhydrase 2 [OS=Homo sapiens]",13,3,4,3,260,29.2,7.4,8.46,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CA2","ENSG00000104267","Proximal tubule transport","Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Nitrogen metabolism; Metabolic pathways; Proximal tubule bicarbonate reclamation; Collecting duct acid secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion",185.6,177.1,168.7,173.1,164.2,169.9,1.0477129337539435,0.06724348235109973,0.21836940829171508,0.6608082026919868,0.3970722729254102,0.40113043813358135,4294]
["High","P00966","Argininosuccinate synthase [OS=Homo sapiens]",19,8,18,8,412,46.5,8.02,33.05,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASS1","ENSG00000130707","Alanine and aspartate metabolism; Amino acid metabolism","Urea cycle","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids; Fluid shear stress and atherosclerosis",1513.2,1248.4,1166.8,883.6,910.6,900.2,1.4579869358669837,0.5439777926111076,0.01720317391680484,1.7643914201046282,0.08155578745744517,1.088545214615747,1647]
["High","P01023","alpha-2-macroglobulin [OS=Homo sapiens]",5,8,58,8,1474,163.2,6.46,101.45,"other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","A2M","ENSG00000175899","Complement system; Complement and coagulation cascades","Degradation of the extracellular matrix; Platelet degranulation ; HDL assembly; Intrinsic Pathway of Fibrin Clot Formation","Complement and coagulation cascades",14548.2,10645.8,8758.7,1617.2,1657.5,2054,6.371666635389494,2.6716707872568812,5.0622881350949655E-3,2.295653139319904,0.04324545487836049,1.3640595303951,914]
["High","P01024","Complement C3 [OS=Homo sapiens]",1,2,4,2,1663,187,6.4,5.7,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","C3","ENSG00000125730","Allograft rejection; Complement system; TYROBP causal network in microglia; Cells and molecules involved in local acute inflammatory response ; 16p11.2 distal deletion syndrome; Complement system in neuronal development and plasticity; Acquired partial lipodystrophy / Barraquer-Simons syndrome; Complement activation; Complement and coagulation cascades","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; G alpha (i) signalling events; Neutrophil degranulation; Peptide ligand-binding receptors; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Purinergic signaling in leishmaniasis infection; Alternative complement activation; Activation of C3 and C5","Neuroactive ligand-receptor interaction; Phagosome; Complement and coagulation cascades; Neutrophil extracellular trap formation; Alcoholic liver disease; Shigellosis; Pertussis; Legionellosis; Leishmaniasis; Chagas disease; Staphylococcus aureus infection; Tuberculosis; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Coronavirus disease; Viral carcinogenesis; Systemic lupus erythematosus",340.3,249.6,207.1,36.4,48,56.1,5.672597864768683,2.504009593769546,0.005283628668427192,2.277067712049145,0.04426456292175914,1.3539438197444909,932]
["High","P01033","Metalloproteinase inhibitor 1 [OS=Homo sapiens]",10,2,2,2,207,23.2,8.1,4.81,"stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","TIMP1","ENSG00000102265","Matrix metalloproteinases; Mammary gland development pathway - Puberty (Stage 2 of 4); IL1 and megakaryocytes in obesity; Lung fibrosis; IL-6 signaling pathway; IL-18 signaling pathway; Burn wound healing; CCL18 signaling pathway","Interleukin-4 and Interleukin-13 signaling; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-10 signaling; Activation of Matrix Metalloproteinases","HIF-1 signaling pathway",125.2,134,121.4,117.3,126.9,114.7,1.0604625243800503,0.08469363845794461,0.24122742516316692,0.6175733187543377,0.4230691230175218,0.37358866975837307,4452]
["High","P01034","Cystatin-C [OS=Homo sapiens]",12,1,1,1,146,15.8,8.75,0,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CST3","ENSG00000101439","","Neutrophil degranulation; Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Salivary secretion",37.8,25.5,29.6,33,36.3,23.5,1.0010775862068966,1.5537912550808155E-3,0.9952581401649621,0.002064261657185177,0.9978140162311279,9.5039984654383155E-4,7788]
["High","P01111","GTPase NRas [OS=Homo sapiens]",69,10,37,3,189,21.2,5.17,55.68,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","NRAS","ENSG00000213281","Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling","Neutrophil degranulation; FCERI mediated MAPK activation; Regulation of RAS by GAPs; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",1223.4,1392.9,1352,1239.3,1346.8,1281.1,1.0261429458005793,0.03723171811144798,0.6036775884837302,0.21919494701967132,0.7484145142713505,0.125857798661561,6298]
["High","P01112","GTPase HRas [OS=Homo sapiens]",55,8,36,1,189,21.3,5.31,57.96,"stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","HRAS","ENSG00000174775; ENSG00000276536","Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; Pathways affected in adenoid cystic carcinoma; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; IL-2 signaling pathway; Malignant pleural mesothelioma; Alzheimer's disease; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling","Regulation of RAS by GAPs; EPHB-mediated forward signaling; FCERI mediated MAPK activation; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Focal adhesion; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Salmonella infection; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",61.2,43,39.8,70.2,66.2,48.9,0.7771181867242309,-0.3637940696975911,0.21428695883119442,0.6690042586361392,0.39248242424442087,0.406179786624636,4263]
["High","P01116-2","Isoform 2B of GTPase KRas [OS=Homo sapiens]",62,9,38,3,188,21.4,8.12,58.59,"","","","KRAS","","","","",433.1,447.3,454.1,524.9,520,465.6,0.8834822906322409,-0.17872687858597452,0.04257412180783316,1.3708543016259758,0.13949590561290867,0.8554385393137964,2383]
["High","P01130","Low-density lipoprotein receptor [OS=Homo sapiens]",10,8,10,8,860,95.3,5.05,17.03,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LDLR","ENSG00000130164","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M signaling pathway; PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Lipid particles composition; Wnt signaling pathway and pluripotency; Statin inhibition of cholesterol production; Bile acids synthesis and enterohepatic circulation ; Metabolic pathway of LDL, HDL and TG, including diseases; Orexin receptor pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; DNA damage response (only ATM dependent)","Cargo recognition for clathrin-mediated endocytosis; Retinoid metabolism and transport; LDL clearance; Chylomicron clearance","Endocytosis; Ovarian steroidogenesis; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Cushing syndrome; Bile secretion; Cholesterol metabolism; Toxoplasmosis; Hepatitis C; Lipid and atherosclerosis",437.9,401.4,411.7,666.7,667.6,713.6,0.6108696713706724,-0.7110634800205043,1.4923377638658948E-4,3.8261328709775038,0.010221204614267461,1.990497917655341,114]
["Medium","P01350","Gastrin [OS=Homo sapiens]",16,1,1,1,101,11.4,5.19,0,"signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","GAST","ENSG00000184502","Gastrin signaling pathway","Gastrin-CREB signalling pathway via PKC and MAPK","Gastric acid secretion",24.2,21.9,19.4,19.7,17.9,19.8,1.1411149825783975,0.19044416974912518,0.14977714283260865,0.8245544583260104,0.31044861461030215,0.5080102738706427,3767]
["Low","P01563","Interferon alpha-2 [OS=Homo sapiens]",10,1,1,1,188,21.5,6.76,0,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","IFNA2","ENSG00000188379","PI3K-Akt signaling pathway; Overview of interferons-mediated signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; SARS coronavirus and innate immunity; Overview of proinflammatory and profibrotic mediators; Type II interferon signaling (IFNG); Toll-like receptor signaling pathway","Factors involved in megakaryocyte development and platelet production; Regulation of IFNA signaling; TRAF6 mediated IRF7 activation","Cytokine-cytokine receptor interaction; PI3K-Akt signaling pathway; Necroptosis; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Alcoholic liver disease; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Autoimmune thyroid disease; Lipid and atherosclerosis",51.4,31.5,62.7,65.2,35.5,56.5,0.9262086513994913,-0.11059086205990992,0.775687046074051,0.11031346118638548,0.8694465196305182,0.060757126649967595,6966]
["High","P01834","immunoglobulin kappa constant [OS=Homo sapiens]",19,1,1,1,107,11.8,6.52,2.75,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGKC","","","FCERI mediated NF-kB activation; Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers","",16.9,20.5,12.9,20.9,10,15.3,1.0887445887445886,0.12266554838946932,0.7396850339704563,0.1309531682790305,0.8464694042563862,0.07238873490030127,6823]
["Medium","P01854","immunoglobulin heavy constant epsilon [OS=Homo sapiens]",4,1,1,1,428,47,8.06,0,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHE","ENSG00000211891; ENSG00000276192","","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; Interleukin-4 and Interleukin-13 signaling","",47.3,46.1,42.4,44.1,40.9,46.7,1.0311313591495825,0.044228133988217636,0.5736513454662795,0.24135198346526987,0.724416902054134,0.14001142530550975,6183]
["High","P02042","Hemoglobin subunit delta [OS=Homo sapiens]",13,2,12,2,147,16,8.05,25.21,"other metabolic processes;transport;other biological processes","cytosol;other cell component","other molecular function","HBD","ENSG00000223609","VEGFA-VEGFR2 signaling pathway","Factors involved in megakaryocyte development and platelet production","",997,702.7,740.1,306.1,312.5,383,2.4359025559105434,1.284456421866389,0.007447257782273969,2.1280036130585382,0.052244554145548204,1.281958972734611,1113]
["High","P02452","Collagen alpha-1(I) chain [OS=Homo sapiens]",9,11,16,11,1464,138.9,5.8,18.87,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi;other cell component","extracellular structural activity;other molecular function","COL1A1","ENSG00000108821","Focal adhesion; Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miR-509-3p alteration of YAP1/ECM axis; PI3K-Akt signaling pathway; Inflammatory response pathway; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Angiotensin II receptor type 1 pathway; Burn wound healing; CCL18 signaling pathway; NRP1-triggered signaling pathways in pancreatic cancer","GPVI-mediated activation cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Collagen degradation; Integrin cell surface interactions; ECM proteoglycans; Collagen chain trimerization; Syndecan interactions; MET activates PTK2 signaling; RUNX2 regulates osteoblast differentiation; Anchoring fibril formation; Crosslinking of collagen fibrils; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); Scavenging by Class A Receptors; GP1b-IX-V activation signalling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Platelet activation; Relaxin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Protein digestion and absorption; Amoebiasis; Human papillomavirus infection; Proteoglycans in cancer; Diabetic cardiomyopathy",4120.4,2792.6,2343.7,282.2,258.2,439,9.45139881560139,3.240527865311086,0.006773808469318645,2.169167087274204,0.050180167484288406,1.2994678934920962,1054]
["High","P02458-1","Isoform 1 of Collagen alpha-1(II) chain [OS=Homo sapiens]",3,4,4,4,1418,134.3,8.56,4.78,"","","","COL2A1","","","","",1380.9,822.3,715.7,99.2,55.2,112.1,10.952720450281426,3.4532173476059356,0.012936516244138784,1.8881826618163096,0.06913642630680056,1.160293073091971,1461]
["High","P02462","Collagen alpha-1(IV) chain [OS=Homo sapiens]",2,3,6,3,1669,160.5,8.28,20.23,"","","","","","","","",227.9,193.3,208,123.4,129.2,146.8,1.5753630445668505,0.6556843379717143,0.003333257628146822,2.4771311183350977,0.035361515707296724,1.4514691280139613,736]
["High","P02533","Keratin, type I cytoskeletal 14 [OS=Homo sapiens]",39,20,65,5,472,51.5,5.16,146.33,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KRT14","ENSG00000186847","Corticotropin-releasing hormone signaling pathway","Formation of the cornified envelope; Type I hemidesmosome assembly","Estrogen signaling pathway; Staphylococcus aureus infection",1742.7,4578.7,1212.4,1423.9,1319.6,1787.3,1.6627968570671845,0.7336119261697799,0.39626351451980346,0.4020159129602123,0.5790802023901601,0.23726128248448283,5343]
["High","P02538","Keratin, type II cytoskeletal 6A [OS=Homo sapiens]",34,21,119,2,564,60,8,216.7,"cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6A","ENSG00000205420","Ectoderm differentiation; Ectoderm differentiation","Formation of the cornified envelope","",801.4,3842.2,394.7,506,488.1,854.8,2.7250256909513757,1.4462698313697213,0.3862904824959449,0.4130859919597926,0.5704853579210021,0.2437554977062686,5287]
["High","P02545","Prelamin-A/C [OS=Homo sapiens]",65,49,228,46,664,74.1,7.02,519.2,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LMNA","ENSG00000160789","Arrhythmogenic right ventricular cardiomyopathy; Adipogenesis; Fas ligand pathway and stress induction of heat shock proteins; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome","XBP1(S) activates chaperone genes; Signaling by BRAF and RAF1 fusions","Apoptosis; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy",8805,8206.2,8555.7,6639,6383.9,6641.5,1.3001617135534267,0.3786910762013353,5.2740565119760126E-4,3.2778552210143603,0.01647193329820348,1.7832554250277626,250]
["High","P02647","Apolipoprotein A-I [OS=Homo sapiens]",8,2,10,1,267,30.8,5.76,21.78,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","APOA1","ENSG00000118137","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5","PPARA activates gene expression; Platelet degranulation ; Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging of heme from plasma; Scavenging by Class B Receptors; Heme signaling; Retinoid metabolism and transport; HDL clearance; Defective ABCA1 causes TGD; HDL assembly; Scavenging by Class A Receptors; ABC transporters in lipid homeostasis; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","PPAR signaling pathway; Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; African trypanosomiasis; Lipid and atherosclerosis",432.3,421.2,363.5,86.1,92.6,104.5,4.2973163841807915,2.1034359975180936,1.4475303109175489E-4,3.839372333489018,0.010182267268147947,1.99215550761704,111]
["High","P02649","Apolipoprotein E [OS=Homo sapiens]",64,18,94,18,317,36.1,5.73,206.13,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","APOE","ENSG00000130203","Vitamin B12 metabolism; Alzheimer's disease and miRNA effects; Apoptosis-related network due to altered Notch3 in ovarian cancer; ApoE and miR-146 in inflammation and atherosclerosis; Statin inhibition of cholesterol production; Familial hyperlipidemia type 3; Alzheimer's disease","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Retinoid metabolism and transport; Nuclear signaling by ERBB4; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors","Cholesterol metabolism; Alzheimer disease",3819.9,3931.3,3926.7,3357.4,3328.3,3418.9,1.1557013637353284,0.2087686498122015,3.1363887101634448E-4,3.5035701181121084,0.013455452224701195,1.871101701438548,182]
["High","P02671-1","Fibrinogen alpha chain [OS=Homo sapiens]",2,3,10,3,866,94.9,6.01,16.25,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGA","ENSG00000171560","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway","Regulation of TLR by endogenous ligand; Platelet degranulation ; Integrin cell surface interactions; Amyloid fiber formation; ER-Phagosome pathway; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease",4699.6,3201.7,2580,154.5,125.1,251,19.753675084809647,4.304049180247468,0.0062410218914649,2.204744294053353,0.048535755904938194,1.3139382022037183,1004]
["High","P02675","Fibrinogen beta chain [OS=Homo sapiens]",11,7,61,7,491,55.9,8.27,96.62,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGB","ENSG00000171564","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway; Complement and coagulation cascades","Platelet degranulation ; Common Pathway of Fibrin Clot Formation; ER-Phagosome pathway; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease",14353.1,8584.5,8352.9,754.9,658,1084,12.531739356802433,3.64751476391907,8.161479810994271E-3,2.088231089348851,0.05451226207377525,1.2635057958520555,1169]
["High","P02679","Fibrinogen gamma chain [OS=Homo sapiens]",7,3,26,3,453,51.5,5.62,46.62,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGG","ENSG00000171557","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway","ER-Phagosome pathway; Platelet degranulation ; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Staphylococcus aureus infection; Coronavirus disease",4212.8,2613.9,2522.4,347.7,368.9,457.6,7.962101856583208,2.9931493274764294,0.007730671135072741,2.1117828013460476,0.05313475371711968,1.2746213280624121,1136]
["High","P02748","complement component C9 [OS=Homo sapiens]",4,2,4,2,559,63.1,5.59,2.69,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes","","C9","ENSG00000113600","Allograft rejection; Complement system; Complement system in neuronal development and plasticity; Complement activation; Complement and coagulation cascades","Regulation of Complement cascade; Terminal pathway of complement","Complement and coagulation cascades; Prion disease; Amoebiasis; Coronavirus disease; Systemic lupus erythematosus",493.1,333.8,276,90.6,102.4,93.5,3.8495636998254805,1.9446949435304408,0.013851832827490857,1.858492758426096,0.07191164276399509,1.143200790023084,1504]
["Medium","P02749","Beta-2-glycoprotein 1 [OS=Homo sapiens]",3,1,1,1,345,38.3,7.97,1.61,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;other cell component","enzyme regulator activity;other molecular function","APOH","ENSG00000091583","","Platelet degranulation","Cholesterol metabolism",52.8,51.1,71,45.4,39.5,51,1.2869757174392935,0.3639848331542613,0.14455005782256283,0.8399817302678654,0.303562897116345,0.5177513110451097,3718]
["High","P02751","fibronectin [OS=Homo sapiens]",30,55,452,55,2386,262.5,5.71,976.91,"","","","","","","","",80901.1,56124.8,51934.1,6481.7,6159.6,9166.5,8.664789662414368,3.1151647284189328,3.5877620288825933E-3,2.445176370803692,0.036618622119627825,1.4362980012986746,765]
["Medium","P02753","Retinol-binding protein 4 [OS=Homo sapiens]",4,1,1,1,201,23,6.07,1.6,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other cell component","transporter activity;other molecular function","RBP4","ENSG00000138207","Sterol regulatory element-binding proteins (SREBP) signaling; Vitamin A and carotenoid metabolism","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events; Retinoid metabolism disease events","",42.7,37.5,45.8,48.5,41.8,34.8,1.0071942446043167,0.010341944221459278,0.9515250255323351,0.021579785088283895,0.9730854485077239,0.011849021822088487,7635]
["Medium","P02760","Protein AMBP [OS=Homo sapiens]",2,1,3,1,352,39,6.25,0,"cell adhesion;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","AMBP","ENSG00000106927","","Scavenging of heme from plasma","",177.7,140.7,162.1,104.8,102.7,104.9,1.5380921895006403,0.6211419775191336,6.457957147423022E-3,2.1899048411242865,0.049002652485013565,1.3097804112280842,1029]
["High","P02765","Alpha-2-HS-glycoprotein [OS=Homo sapiens]",7,4,33,4,367,39.3,5.72,45.09,"","","","","","","","",1461.3,1356.6,1695.4,1270.7,1377.5,1374,1.1220973596539205,0.1661978579397042,0.19773690452915066,0.7039122687862859,0.37256992050280124,0.42879221086482705,4144]
["High","P02768-1","Serum albumin [OS=Homo sapiens]",8,6,55,6,609,69.3,6.28,93.09,"stress response;other biological processes","non-structural extracellular;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","ALB","ENSG00000163631","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; VEGFA-VEGFR2 signaling pathway","Cytoprotection by HMOX1; Scavenging of heme from plasma; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Recycling of bile acids and salts; Heme degradation; HDL remodeling; Heme biosynthesis","Thyroid hormone synthesis",2394.3,2396.2,2611.2,2162.9,2159.5,2182.2,1.1379177812624912,0.18639632139668288,0.014444475961190334,1.8402982095339877,0.07328295536385583,1.134997024706831,1539]
["High","P02771","Alpha-fetoprotein [OS=Homo sapiens]",3,2,3,2,609,68.6,5.68,8.34,"other metabolic processes;developmental processes;signal transduction","non-structural extracellular;ER/Golgi;other cell component","other molecular function","AFP","ENSG00000081051","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Hippo signaling pathway",148.2,141.5,159.2,110.5,131.4,122.1,1.2332417582417583,0.30245564582948636,0.02357134059051086,1.6276157168178578,0.09727538442426469,1.0119970442249964,1892]
["High","P02774","vitamin D-binding protein [OS=Homo sapiens]",10,4,11,4,474,52.9,5.54,34.45,"transport","non-structural extracellular","transporter activity;cytoskeletal activity;other molecular function","HEL-S-51","","","","",305.5,296,319.4,242.8,250.6,256.7,1.2277029729369417,0.2959615612747764,1.9615808508036785E-3,2.7073937867777516,0.02906266277623363,1.5366645973316628,527]
["High","P02792","Ferritin light chain [OS=Homo sapiens]",40,6,15,6,175,20,5.78,39.57,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTL","ENSG00000087086","Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Ferroptosis; Necroptosis; Mineral absorption",870.9,823.3,885.5,377.4,411.5,408.8,2.153878266677799,1.106936713659681,2.9300091916142206E-5,4.533131017235967,0.004973372123505181,2.303349044258906,46]
["High","P03905","NADH-ubiquinone oxidoreductase chain 4 [OS=Homo sapiens]",6,2,2,2,459,51.5,9.35,2.5,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-ND4","ENSG00000198886","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",80.2,96.2,80.6,90.2,113.9,101.8,0.8401438378555083,-0.25129174747696215,0.1321105245533234,0.8790625830413097,0.2882948506742171,0.5401631146140285,3578]
["High","P04062","glucosylceramidase [OS=Homo sapiens]",6,3,3,3,536,59.7,7.61,8.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GBA","ENSG00000177628","Sphingolipid pathway","Glycosphingolipid metabolism; Association of TriC/CCT with target proteins during biosynthesis","Other glycan degradation; Sphingolipid metabolism; Metabolic pathways; Lysosome",197.3,194.3,177.2,169.7,186,196.1,1.0308082638637188,0.04377600826614244,0.5982806659373096,0.2230950316095856,0.744086562541974,0.1283765383149738,6278]
["Medium","P04150","Glucocorticoid receptor [OS=Homo sapiens]",1,1,1,1,777,85.6,6.38,2.62,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","NR3C1","ENSG00000113580","Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling","Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression","Neuroactive ligand-receptor interaction",43.4,33.9,34.5,45.1,41.8,43.6,0.8567049808429118,-0.2231296186140569,0.12465522579128926,0.9042895103030218,0.2773747514899933,0.5569330738597927,3509]
["Medium","P04437","T-cell receptor alpha chain V region CTL-L17 [OS=Homo sapiens]",5,1,1,1,139,15.4,8.43,2.06,"","","","","","","","",121.3,106.6,91.8,85.5,96.3,69.5,1.2721846398726622,0.3473080728998649,0.11933602879485906,0.9232284184876917,0.26968906304783197,0.5691366655392736,3455]
["High","P04733","Metallothionein-1F [OS=Homo sapiens]",33,2,13,1,61,6.1,7.83,22.3,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1F","ENSG00000198417","Copper homeostasis; Zinc homeostasis","Metallothioneins bind metals","Mineral absorption",508.1,511.8,604.7,628.3,656.6,661.2,0.8347978007296645,-0.2605012951569671,0.03213739466810561,1.4929893337683118,0.11671105933421796,0.9328879890252817,2150]
["High","P04920-1","Anion exchange protein 2 [OS=Homo sapiens]",8,5,9,5,1241,136.9,6.29,19.31,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC4A2","ENSG00000164889","Proximal tubule transport","Bicarbonate transporters","Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion",111.9,110.9,122.9,131,112.3,143.3,0.8942058975685464,-0.16132103394883696,0.2364775910245386,0.626210007380662,0.41726938547335535,0.3795834777558708,4425]
["High","P05067-8","Isoform APP751 of Amyloid-beta A4 protein [OS=Homo sapiens]",40,20,50,1,751,84.8,4.79,114.1,"","","","APP","","","","",23,16,20.8,23.1,22.9,22.4,0.8742690058479532,-0.19385084068779287,0.23966903034735904,0.6203880811862109,0.42166196235966186,0.37503557442356505,4438]
["High","P05141","ADP/ATP translocase 2 [OS=Homo sapiens]",51,18,174,5,298,32.8,9.69,350.99,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","transporter activity;other molecular function","SLC25A5","ENSG00000005022","Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization","Calcium signaling pathway; cGMP-PKG signaling pathway; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Influenza A; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy",9531.8,10582.1,9816.4,8418.5,10021.8,9584,1.06801240352123,0.09492840207664423,0.32901647360685227,0.4827823567082556,0.5161664910432595,0.2872101927936433,4977]
["High","P05387","60S acidic ribosomal protein P2 [OS=Homo sapiens]",70,5,26,5,115,11.7,4.54,87.36,"protein metabolism;other metabolic processes","cytosol;translational apparatus","other molecular function","RPLP2","ENSG00000177600","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",768.3,756.2,837.9,990.4,747.2,608.9,1.0067760494353293,9.742801218328833E-3,0.9652622735650294,0.015354667499637653,0.9816056045839736,0.008062970622388378,7678]
["High","P05423","DNA-directed RNA polymerase III subunit RPC4 [OS=Homo sapiens]",29,9,25,9,398,44.4,6.98,52.77,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3D","ENSG00000168495","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",1128.9,1197.1,1151.5,1237.3,1295.4,1232.7,0.9235406596908696,-0.11475261636173453,0.027962089418718545,1.5534303798106124,0.10712855455414838,0.9700947548223845,2038]
["High","P05937","Calbindin [OS=Homo sapiens]",15,2,4,2,261,30,4.83,6.53,"developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CALB1","ENSG00000104327","","Amyloid fiber formation","Endocrine and other factor-regulated calcium reabsorption",110.4,99.5,114.1,84.9,78.4,79.4,1.3349814585908528,0.41681970462085327,0.004941293935417303,2.3061593111110086,0.0425845729003734,1.3707477041291865,906]
["High","P06280","alpha-galactosidase A [OS=Homo sapiens]",25,8,30,8,429,48.7,5.6,70.75,"other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","GLA","ENSG00000102393","Degradation pathway of sphingolipids, including diseases; Ciliary landscape","Neutrophil degranulation; Glycosphingolipid metabolism","Galactose metabolism; Glycerolipid metabolism; Sphingolipid metabolism; Glycosphingolipid biosynthesis; Metabolic pathways; Lysosome",979.3,978.5,1004,982.8,958.3,966.8,1.0185357130575332,0.02649656660493758,0.17863538033417797,0.7480325210232552,0.3490453077200354,0.45711819591856456,3996]
["High","P06733-1","alpha-enolase [OS=Homo sapiens]",81,35,836,30,434,47.1,7.39,1693.12,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","ENO1; HEL-S-17; LOC117800423","ENSAMEG00000029491; ENSG00000074800; ENSGGOG00000010357; ENSPPAG00000003541; ENSPPYG00000001920; ENSPTRG00000000109","Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis","Gluconeogenesis; Glycolysis; Manipulation of host energy metabolism","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway",29193.8,28718.4,29329.1,29514.5,29461,29842.7,0.9822457559374091,-0.025844065750135734,0.07549165051993564,1.122101079279937,0.19980976517276527,0.6993832905994647,2950]
["High","P06748","Nucleophosmin [OS=Homo sapiens]",63,19,563,19,294,32.6,4.78,1527.79,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","cytosol;cytoskeleton;translational apparatus;nucleus;other cell component","enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function","NPM1","ENSG00000181163","","TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Nuclear events stimulated by ALK signaling in cancer; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation","",17386.1,16601.2,17698.2,18037,16185.3,16103.7,1.027013869570401,0.03845566503032813,0.5583477185875874,0.2530952540523568,0.7137490155094763,0.14645447777810505,6108]
["High","P07093-1","Glia-derived nexin [OS=Homo sapiens]",14,4,10,4,398,44,9.29,19.88,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SERPINE2","ENSG00000135919","","Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Dissolution of Fibrin Clot","",342.4,318.4,329.6,247.7,237.6,267.6,1.3154469385044494,0.39555305534499463,2.1230348386543215E-3,2.67304287907414,0.029548406453142502,1.5294659356716658,561]
["High","P07355","Annexin A2 [OS=Homo sapiens]",69,30,235,30,339,38.6,7.75,501.76,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","ANXA2","ENSG00000182718","Gastrin signaling pathway; CCL18 signaling pathway; Prostaglandin synthesis and regulation","Smooth Muscle Contraction; Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Dissolution of Fibrin Clot","Salmonella infection",9231.7,9731.4,9460,8459.8,9124.8,8751.9,1.0792284472120441,0.1100002816705439,0.04453144847322549,1.3513331783541098,0.14344123336590126,0.843325989189723,2424]
["High","P07384","Calpain-1 catalytic subunit [OS=Homo sapiens]",54,34,124,33,714,81.8,5.67,250.54,"protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","CAPN1","ENSG00000014216","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease","Degradation of the extracellular matrix; Neutrophil degranulation; Formation of the cornified envelope; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Protein processing in endoplasmic reticulum; Apoptosis; Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis",5052.2,5132.5,5042.7,5104.8,5487,5287.8,0.9589284364845463,-0.06050494198102529,0.1291411887380006,0.8889352202534099,0.28371817717116166,0.5471128390640573,3554]
["High","P07741-1","Adenine phosphoribosyltransferase [OS=Homo sapiens]",83,12,86,12,180,19.6,6.02,171.04,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","APRT","ENSG00000198931; ENSPPAG00000005769; ENSPTRG00000008466","","Neutrophil degranulation; Purine salvage","Purine metabolism; Metabolic pathways",3182.1,3282.3,3338.1,3094.6,3223.5,3149.4,1.0353842091365195,0.05016622063216982,0.1312115790002931,0.8820278381764897,0.286974792390557,0.5421562496300475,3570]
["High","P07951-1","Tropomyosin beta chain [OS=Homo sapiens]",58,26,115,6,284,32.8,4.7,216.72,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","TPM2","ENSANAG00000037556; ENSCANG00000042880; ENSCATG00000041575; ENSCCAG00000023807; ENSG00000198467; ENSMFAG00000002090; ENSMLEG00000037634; ENSMMUG00000016321; ENSMNEG00000031621; ENSNLEG00000004274; ENSPANG00000025431; ENSPPAG00000030835; ENSPTRG00000024321; ENSRBIG00000029128; ENSRROG00000041510; ENSSBOG00000021703","Striated muscle contraction pathway","Striated Muscle Contraction; Smooth Muscle Contraction","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Hypertrophic cardiomyopathy; Dilated cardiomyopathy",1684.9,1298.4,1719.7,1440.2,1306.6,1380.8,1.1394030429305164,0.18827816423932237,0.243755985384537,0.6130447114753247,0.42635455508119735,0.37022909274621163,4464]
["High","P08069","Insulin-like growth factor 1 receptor [OS=Homo sapiens]",9,10,16,9,1367,154.7,5.8,22.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;transporter activity;kinase activity;other molecular function","IGF1R","ENSG00000140443","MicroRNAs in cardiomyocyte hypertrophy; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Apoptosis; Focal adhesion; MECP2 and associated Rett syndrome; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Ebola virus infection in host; Ras signaling; Breast cancer pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Head and neck squamous cell carcinoma; Endochondral ossification; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Malignant pleural mesothelioma","Extra-nuclear estrogen signaling; IRS-related events triggered by IGF1R; Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R); SHC-related events triggered by IGF1R","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Oocyte meiosis; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Long-term depression; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Pathways in cancer; Transcriptional misregulation in cancer; Proteoglycans in cancer; Glioma; Prostate cancer; Melanoma; Breast cancer; Hepatocellular carcinoma",376.3,395.4,356.7,396.1,400.3,414.3,0.9320227967291651,-0.10156285210448895,0.09235463379542982,1.0345413094137907,0.22733448318875035,0.6433346834007216,3172]
["High","P08195","4F2 cell-surface antigen heavy chain [OS=Homo sapiens]",37,19,75,19,630,68,5.01,176.48,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","transporter activity;nucleic acid binding activity;other molecular function","SLC3A2","ENSG00000168003","mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; Proximal tubule transport; Malignant pleural mesothelioma","Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)","mTOR signaling pathway; Ferroptosis; Protein digestion and absorption",3193.5,3255.7,3233.9,3082.2,3158.6,3177.6,1.0281045612842947,0.03998699835972129,0.062212823899868895,1.2061200851659906,0.17568091465105834,0.7552754161480721,2765]
["Medium","P08247","Synaptophysin [OS=Homo sapiens]",5,2,2,2,313,33.8,4.81,2.16,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SYP","ENSG00000102003","Synaptic vesicle pathway","Sensory processing of sound by inner hair cells of the cochlea","",101.6,79.3,112.2,78.9,80.6,77,1.2393234672304438,0.3095527844627837,0.12512010176697888,0.9026729110487781,0.27809215900841766,0.5558112561821682,3513]
["High","P08473","Neprilysin [OS=Homo sapiens]",11,6,8,6,750,85.5,5.73,9.23,"protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","MME","ENSG00000196549","Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Alzheimer's disease","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","Renin-angiotensin system; Hematopoietic cell lineage; Protein digestion and absorption; Alzheimer disease",149.2,143.6,152.6,163.9,174.4,152.4,0.9076829019767677,-0.13973971328043788,0.09298075432084699,1.0316069348570338,0.2284435902256681,0.6412210230697593,3178]
["High","P08621-1","U1 small nuclear ribonucleoprotein 70 kDa [OS=Homo sapiens]",50,20,154,20,437,51.5,9.94,380.18,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","SNRNP70; SNRP70","ENSCATG00000016149; ENSG00000104852; ENSGGOG00000008245; ENSMLEG00000030967; ENSPANG00000004068; ENSPPAG00000035067; ENSPTRG00000011277; ENSRROG00000033636","mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway","Spliceosome",6391.8,6723,6721.5,6971.2,6801.5,7071.6,0.9516414559375942,-0.07150997426674559,0.06816289011147957,1.1664520037334651,0.18687354142922485,0.7284521840396486,2848]
["High","P08962","CD63 antigen [OS=Homo sapiens]",13,4,35,4,238,25.6,7.81,62.36,"cell adhesion;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","","CD63","ENSG00000135404","Extracellular vesicles in the crosstalk of cardiac cells","Neutrophil degranulation; Platelet degranulation","Lysosome; Proteoglycans in cancer",2148.6,2196.7,2243.8,1857.6,1789.7,1866.2,1.1950847918744898,0.25711298178517494,6.0961388923519216E-4,3.2149451467381973,0.01749950458510434,1.7569742461137607,272]
["High","P09001","39S ribosomal protein L3, mitochondrial [OS=Homo sapiens]",30,7,22,7,348,38.6,9.48,40.19,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL3","ENSG00000114686","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",946,918.8,920.3,930.7,902.5,949.9,1.0007186231181058,1.0363816694305477E-3,0.9694340387905879,0.013481735387561289,0.9834144439232051,0.007263417288405612,7697]
["Medium","P09382","Galectin-1 [OS=Homo sapiens]",6,1,1,1,135,14.7,5.5,2.09,"stress response;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LGALS1","ENSG00000100097","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",48.7,56,44.8,63.4,52.3,39.8,0.9614147909967846,-0.05676909593249743,0.8045752407627258,0.09443333612664022,0.8888120373338092,0.05119007230273126,7068]
["High","P09496-2","Isoform Non-brain of Clathrin light chain A [OS=Homo sapiens]",24,5,11,5,218,23.6,4.53,24.57,"","","","CLTA","","","","",419.7,370.1,406.5,770.5,422.4,359.8,0.7704643524183679,-0.37619988672479976,0.40790681828059444,0.38943903526420004,0.5899122869299651,0.2292125580768071,5399]
["High","P09525","annexin A4 [OS=Homo sapiens]",44,13,29,12,319,35.9,6.13,41.2,"signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","enzyme regulator activity;other molecular function","ANXA4","ENSG00000196975","Prostaglandin synthesis and regulation","","",599.8,607.7,558.8,616.9,647.6,634,0.9303660784830128,-0.1041295983519005,0.06615884962597626,1.1794120549282145,0.18337532761079964,0.7366590972553526,2817]
["High","P09884","DNA polymerase alpha catalytic subunit [OS=Homo sapiens]",26,30,71,30,1462,165.8,5.85,155.47,"cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLA1","ENSG00000101868","Retinoblastoma gene in cancer; Pyrimidine metabolism; Nucleotide metabolism; DNA replication","Defective pyroptosis; Activation of the pre-replicative complex; G1/S-Specific Transcription; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate","DNA replication",3231.1,3206.3,3168.1,3465,3334.6,3398.4,0.9419003726220828,-0.08635362477886778,0.009190907808734545,2.0366415901533275,0.05829618860324884,1.2343598384260084,1231]
["Medium","P09958","Furin [OS=Homo sapiens]",1,1,1,1,794,86.6,6.47,2.67,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","FURIN","ENSG00000140564","SARS-CoV-2 altering angiogenesis via NRP1","Potential therapeutics for SARS; Formation of the cornified envelope; Amyloid fiber formation; Collagen degradation; Signaling by PDGF; Signaling by NODAL; Pre-NOTCH Processing in Golgi; Uptake and function of anthrax toxins; Attachment and Entry; Assembly of active LPL and LIPC lipase complexes; Activation of Matrix Metalloproteinases; TGF-beta receptor signaling activates SMADs; Removal of aminoterminal propeptides from gamma-carboxylated proteins; NGF processing; Synthesis and processing of ENV and VPU; Elastic fibre formation; CD163 mediating an anti-inflammatory response","",58.6,58.6,56.7,81.9,73.3,73.4,0.7607174103237095,-0.39456747090789107,3.3512120904905197E-3,2.4747980857979934,0.03540766441481729,1.4509027195341837,739]
["High","P0CG38","POTE ankyrin domain family member I [OS=Homo sapiens]",11,10,241,1,1075,121.2,6.21,501.86,"","","","POTEI","ENSG00000196834","","","",922,878.1,1016.4,780.5,753.4,819.7,1.1966774303195105,0.25903431987208037,0.026771548675212448,1.5723265051057465,0.10472557718239418,0.9799472373984633,1996]
["High","P10070-1","Isoform 1 of Zinc finger protein GLI2 [OS=Homo sapiens]",5,4,5,2,1258,133.2,7.14,12.6,"","","","GLI2","","","","",106,108.5,90.1,116.4,109.3,122.1,0.8757906843013228,-0.19134199081929465,0.10336183146771934,0.9856398040192945,0.24560230678635195,0.6097675584597021,3286]
["High","P10109","Adrenodoxin, mitochondrial [OS=Homo sapiens]",16,2,10,2,184,19.4,5.83,18.72,"other metabolic processes;other biological processes","mitochondrion","other molecular function","FDX1","ENSG00000137714","","Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin","",183.2,164.9,200.1,155.6,118,132.1,1.3512447621395118,0.43428902561950217,0.033640024469954614,1.4731436969656118,0.12010119390096279,0.9204526753446136,2187]
["High","P10398-1","serine/threonine-protein kinase A-Raf [OS=Homo sapiens]",21,10,14,7,606,67.5,9.01,21.9,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","ARAF","ENSG00000078061; ENSGGOG00000008695; ENSPPAG00000015632; ENSPTRG00000021846","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Common pathways underlying drug addiction; Bladder cancer; MAPK signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Alzheimer's disease; ErbB signaling pathway","Signaling by BRAF and RAF1 fusions; RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; FoxO signaling pathway; Vascular smooth muscle contraction; Natural killer cell mediated cytotoxicity; Long-term potentiation; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Parathyroid hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Pathways in cancer; Proteoglycans in cancer; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer",864.9,861.3,847.6,874,986.1,919.6,0.9259272583372307,-0.11102923634600127,0.10583044555343261,0.9753893754600447,0.2490428326947564,0.6037259524897512,3318]
["High","P10620","Microsomal glutathione S-transferase 1 [OS=Homo sapiens]",23,3,16,3,155,17.6,9.39,26.69,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGST1","ENSG00000008394","Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Oxidative stress response; Metapathway biotransformation Phase I and II","Neutrophil degranulation; Aflatoxin activation and detoxification; Glutathione conjugation","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",796.5,911.7,847,719,951.3,847.2,1.0149751737835153,0.021444439629723144,0.8750585327760945,0.05796289599316059,0.927818715903822,0.032536871166502286,7364]
["High","P10809","60 kDa heat shock protein, mitochondrial [OS=Homo sapiens]",83,51,1952,51,573,61,5.87,4312.07,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","HSPD1","ENSG00000144381","Apoptosis-related network due to altered Notch3 in ovarian cancer; Sudden infant death syndrome (SIDS) susceptibility pathways","Mitochondrial protein import; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation","RNA degradation; Type I diabetes mellitus; Legionellosis; Tuberculosis; Lipid and atherosclerosis",43092.8,41610.2,42969,43167.6,42084,43298.2,0.9931715179642442,-0.009885206188691063,0.6571496883445118,0.18233569373173852,0.787087707714979,0.1039768701132901,6519]
["High","P11137","microtubule-associated protein 2 [OS=Homo sapiens]",8,10,19,3,1827,199.4,4.91,47.97,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAP2","ENSG00000078018","Melatonin metabolism and effects; MAPK cascade; Sudden infant death syndrome (SIDS) susceptibility pathways","","",688.5,672.9,679.5,589.8,485,510.4,1.2874716124148373,0.3645406225251066,8.879720221626957E-3,2.0516007175679905,0.05711108360005212,1.2432795996485937,1214]
["High","P11177","Pyruvate dehydrogenase E1 component subunit beta, mitochondrial [OS=Homo sapiens]",48,13,113,13,359,39.2,6.65,231.16,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","PDHB","ENSG00000168291","Metabolic reprogramming in colon cancer; Orexin receptor pathway","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Glycolysis / Gluconeogenesis; Citrate cycle (TCA cycle); Pyruvate metabolism; Metabolic pathways; Carbon metabolism; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer; Diabetic cardiomyopathy",5072.4,5036.4,5050.4,4988.3,5217.8,5191.9,0.9844914924016105,-0.022549355924615953,0.33869525674249656,0.4701908853895721,0.5250213549028019,0.2798230315886479,5037]
["High","P11233","Ras-related protein Ral-A [OS=Homo sapiens]",42,9,54,5,206,23.6,7.11,136.81,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","RALA","ENSG00000006451","RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; p38MAPK events","Ras signaling pathway; Rap1 signaling pathway; Phospholipase D signaling pathway; Salmonella infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer",1982.1,1984.3,2030,1882.5,1974.8,1892.3,1.0429247251982745,0.06063503273572335,0.06822211126183418,1.1660748446592497,0.18683908969919372,0.7285322573100743,2851]
["High","P11441","Ubiquitin-like protein 4A [OS=Homo sapiens]",29,4,8,4,157,17.8,8.66,12.29,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;cytosol;nucleus;other cell component","other molecular function","UBL4A","ENSG00000102178","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",162.6,159.9,174.9,217.1,168.5,170.4,0.8946043165467624,-0.16067837539396349,0.30328083434692277,0.5181550338052893,0.4900696925870805,0.3097421547597293,4832]
["High","P11717","Cation-independent mannose-6-phosphate receptor [OS=Homo sapiens]",25,50,104,50,2491,274.2,5.94,235.02,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","IGF2R","ENSG00000197081","","Retrograde transport at the Trans-Golgi-Network; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis","Lysosome; Endocytosis",3748.7,3881.1,4039.9,4083,4154.2,4149.4,0.9421229393053783,-0.08601276291190643,0.051976442025149484,1.2841934528405983,0.15681300592440772,0.8046179201786258,2588]
["High","P12036","Neurofilament heavy polypeptide [OS=Homo sapiens]",4,4,11,2,1026,112.4,6.18,23.38,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","NEFH","ENSG00000100285","Amyotrophic lateral sclerosis (ALS); Physico-chemical features and toxicity-associated pathways","","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",31.3,25,36.2,22.3,36.1,28.3,1.0668973471741636,0.09342137218183925,0.7261516009373706,0.1389727008187503,0.8357593897581058,0.07791873540877231,6784]
["High","P12259","Coagulation factor V [OS=Homo sapiens]",0,1,2,1,2224,251.5,6.05,4.92,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","F5","ENSG00000198734","Blood clotting cascade; Complement and coagulation cascades","COPII-mediated vesicle transport; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Platelet degranulation ; Cargo concentration in the ER; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",164.1,124,154.9,76.1,78.2,97.1,1.7621320604614161,0.817322049021873,0.009932225161900302,2.002953443621861,0.060967621119589276,1.2149007502756204,1272]
["High","P12277","Creatine kinase B-type [OS=Homo sapiens]",77,19,172,18,381,42.6,5.59,440.14,"other metabolic processes;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","kinase activity;other molecular function","CKB","ENSG00000166165","","RND3 GTPase cycle; Creatine metabolism","Arginine and proline metabolism; Metabolic pathways",4349.3,4245,4267.7,4093.3,3876.7,3861.7,1.0870796250750103,0.12045761699230997,0.013404218838668856,1.8727584904420715,0.07043078108501105,1.1522374952079926,1486]
["High","P12955","xaa-Pro dipeptidase [OS=Homo sapiens]",33,15,47,15,493,54.5,6,105.32,"protein metabolism;other metabolic processes","","other molecular function","PEPD","ENSG00000124299","","","",1527.7,1578.9,1565.9,1510.9,1519.6,1505.4,1.0301153023655725,0.04280582948711361,0.04585389694291685,1.3386237494402646,0.14553952330499786,0.8370190518850084,2460]
["Medium","P13056-1","Nuclear receptor subfamily 2 group C member 1 [OS=Homo sapiens]",1,1,1,1,603,67.3,6.32,1.83,"signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NR2C1","ENSG00000120798","","Nuclear Receptor transcription pathway; SUMOylation of intracellular receptors","",21.8,30,27.6,36,28.8,27.8,0.8574514038876891,-0.22187318611727835,0.2828207186350966,0.5484887785409672,0.46854745832863026,0.3292464136419676,4713]
["High","P13533","myosin-6 [OS=Homo sapiens]",3,5,14,3,1939,223.6,5.73,30.89,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYH6","ENSG00000197616","Cardiac progenitor differentiation; Striated muscle contraction pathway; Acute viral myocarditis; IL-18 signaling pathway","Striated Muscle Contraction","cGMP-PKG signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Thyroid hormone signaling pathway; Hypertrophic cardiomyopathy; Dilated cardiomyopathy; Viral myocarditis",128.9,116.6,132.4,119.6,91.3,109,1.1813066583307283,0.24038352614428776,0.11277347261884006,0.9477930461872595,0.2593623782644781,0.5860930201451445,3395]
["Medium","P13682","Zinc finger protein 35 [OS=Homo sapiens]",2,1,1,1,527,59.1,8.09,0,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF35","ENSG00000169981; ENSG00000281306","","","",27.1,36.5,38,29.8,42.9,42.2,0.8842471714534377,-0.1774783958739476,0.46185105545699395,0.33549805955736056,0.6392719448693864,0.19431435462411883,5641]
["Medium","P13726-1","tissue factor [OS=Homo sapiens]",5,2,4,1,295,33,7.03,7.18,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","F3","ENSG00000117525","Blood clotting cascade; VEGFA-VEGFR2 signaling pathway; Macrophage markers; STING pathway in Kawasaki-like disease and COVID-19; Complement and coagulation cascades","NGF-stimulated transcription; Extrinsic Pathway of Fibrin Clot Formation","Complement and coagulation cascades; AGE-RAGE signaling pathway in diabetic complications",143.5,146,172.8,159.9,165.1,169.8,0.9343168957154405,-0.09801613774042832,0.3311539392278428,0.4799700744545088,0.5184780343876071,0.28526963801423644,4987]
["High","P13984","General transcription factor IIF subunit 2 [OS=Homo sapiens]",58,13,28,13,249,28.4,9.23,46.49,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","GTF2F2","ENSG00000188342","Eukaryotic transcription initiation","Estrogen-dependent gene expression; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","Basal transcription factors",1324.3,1335.8,1457.3,1467.3,1285.8,1438.4,0.9823213646665869,-0.025733018041414008,0.7439931428552733,0.12843106718777736,0.8496560566643226,0.07075684242917996,6837]
["Medium","P14415","sodium/potassium-transporting ATPase subunit beta-2 [OS=Homo sapiens]",3,1,1,1,290,33.3,8.31,2.01,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ATP1B2","ENSG00000129244","Calcium regulation in cardiac cells","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS; Basigin interactions","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption",27.8,36,29.4,30.3,32.2,32.2,0.9841605068637802,-0.023034470814104986,0.8562284063191242,0.06741036806559327,0.91757224767221,0.037359730312854944,7286]
["High","P14550","alcohol dehydrogenase [NADP(+)] [OS=Homo sapiens]",66,20,102,19,325,36.6,6.79,241.94,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","AKR1A1","ENSG00000117448","Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II","Glutathione conjugation; Formation of xylulose-5-phosphate","Glycolysis / Gluconeogenesis; Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Glycerolipid metabolism; Pyruvate metabolism; Metabolic pathways; Biosynthesis of cofactors; Chemical carcinogenesis",4464,4363.1,4559.1,4178,4172.4,4018.9,1.0822116045370394,0.11398261651087783,0.011638794445707347,1.9340920018761336,0.06599542994341537,1.180486137474422,1377]
["High","P14859-1","POU domain, class 2, transcription factor 1 [OS=Homo sapiens]",15,8,23,8,743,76.4,6.81,50.59,"other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","POU2F1","ENSG00000143190","Integrated cancer pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling","Herpes simplex virus 1 infection; Lipid and atherosclerosis",552.4,583.1,558.7,647.5,615.5,644.7,0.8880851286889972,-0.17123012005638066,0.006831187670075971,2.1655037833288104,0.05036630153725513,1.2978599387776601,1059]
["High","P14868","Aspartate--tRNA ligase, cytoplasmic [OS=Homo sapiens]",65,29,143,29,501,57.1,6.55,308.42,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","DARS1","ENSG00000115866","Alanine and aspartate metabolism","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",6722.7,6901.7,6594.8,6693.7,7382.6,7153.3,0.9524060745374384,-0.0703512726022042,0.20257149183332362,0.693421673539555,0.37812053746942165,0.4223697334615499,4183]
["High","P15260","Interferon gamma receptor 1 [OS=Homo sapiens]",4,2,3,2,489,54.4,4.91,3.74,"stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","IFNGR1","ENSG00000027697","Immune response to tuberculosis; Selective expression of chemokine receptors during T-cell polarization; Overview of interferons-mediated signaling pathway; Neuroinflammation and glutamatergic signaling; Type II interferon signaling (IFNG)","Potential therapeutics for SARS; Regulation of IFNG signaling","Cytokine-cytokine receptor interaction; HIF-1 signaling pathway; Necroptosis; Osteoclast differentiation; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Th1 and Th2 cell differentiation; Th17 cell differentiation; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Inflammatory bowel disease",88.3,97,101.9,87.7,66,80.8,1.2247334754797443,0.2924678264203127,0.08015697314437478,1.0960586908220757,0.2084134686351243,0.6810742183624213,3003]
["High","P15559-1","NAD(P)H dehydrogenase [quinone] 1 [OS=Homo sapiens]",31,7,15,7,274,30.8,8.88,40.65,"cell-cell signaling;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","NQO1","ENSG00000181019; ENSGGOG00000003294; ENSPTRG00000008284","Dopamine metabolism; Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Interactions between LOXL4 and oxidative stress pathway; Benzene metabolism; Oxidative stress response; NRF2-ARE regulation; Male infertility; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Estrogen metabolism","Regulation of ornithine decarboxylase (ODC)","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Pathways in cancer; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",875.5,961.5,896.1,857.9,982.1,871.1,1.008114787355686,0.011659918322333384,0.883938316989466,0.05357803988032226,0.9324223695019928,0.030387315980779855,7402]
["High","P16050","arachidonate 15-lipoxygenase [OS=Homo sapiens]",3,2,2,2,662,74.8,6.58,4.95,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","ALOX15","ENSG00000161905","Eicosanoid synthesis; Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence","Interleukin-4 and Interleukin-13 signaling; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of E-series 18(R)-resolvins; Biosynthesis of DPAn-3-derived protectins and resolvins; Biosynthesis of DPAn-6 SPMs","Arachidonic acid metabolism; Linoleic acid metabolism; Metabolic pathways; Ferroptosis; Necroptosis; Serotonergic synapse",156.3,135.6,144.1,133.3,129.9,110.6,1.1663991439272337,0.22206156591913045,0.08910809172536509,1.0500828567699492,0.22321333981124497,0.6512798543881536,3117]
["High","P16083","Ribosyldihydronicotinamide dehydrogenase [quinone] [OS=Homo sapiens]",55,9,27,9,231,25.9,6.29,54.3,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","NQO2","ENSG00000124588","Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling","Phase I - Functionalization of compounds","",1109.7,1042.2,1073.8,1133.6,1107.4,1125.1,0.9582900092094709,-0.06146576718050363,0.08943968923501348,1.04846971844416,0.22347042993503527,0.6507799354656186,3125]
["High","P16383-1","GC-rich sequence DNA-binding factor 2 [OS=Homo sapiens]",19,11,17,11,781,89.3,5.99,39.09,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity","GCFC2","ENSG00000005436","","mRNA Splicing - Major Pathway","",552.1,536.4,494.8,706.2,596.4,648.3,0.8115741452662874,-0.3012051897364264,0.02724726757477972,1.5646770433577937,0.10563389534452833,0.9761967049167574,2014]
["High","P16435","NADPH--cytochrome P450 reductase [OS=Homo sapiens]",55,33,95,33,677,76.6,5.58,193.45,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","POR","ENSG00000127948","Oxidation by cytochrome P450; Ferroptosis","Cytochrome P450 - arranged by substrate type","",3970,4318.6,4299,3688.7,4023.7,3925.7,1.081585482166333,0.11314769195166677,0.10343653528382495,0.985326035037144,0.24570504030912843,0.609585934460133,3287]
["High","P16989-1","Y-box-binding protein 3 [OS=Homo sapiens]",66,17,93,12,372,40.1,9.77,253.02,"stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CSDA; YBX3","ENSG00000060138","RalA downstream regulated genes; Apoptosis-related network due to altered Notch3 in ovarian cancer","","Tight junction",2014.2,1962.7,2078.3,2427.9,2222.2,2254.6,0.8769678624704911,-0.18940412052292127,0.017124567269194767,1.7663803941406657,0.08138077981611244,1.089478152917092,1643]
["High","P17081","Rho-related GTP-binding protein RhoQ [OS=Homo sapiens]",9,2,16,1,205,22.6,6.32,40.42,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","other molecular function","RHOQ","ENSG00000119729","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling","RHOQ GTPase cycle; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases regulate CFTR trafficking","Insulin signaling pathway",38.3,36.8,36.6,44.2,28.6,40.6,0.9850088183421514,-0.021791454458914422,0.9107223023682005,0.04061402800431963,0.9507848291069542,0.021917756569120057,7479]
["High","P17096-2","Isoform HMG-Y of High mobility group protein HMG-I/HMG-Y [OS=Homo sapiens]",49,5,11,1,96,10.7,10.32,23.63,"","","","HMGA1","","","","",469.9,531.3,443.2,646.9,577,463.2,0.8561436785015707,-0.2240751640699984,0.24584740797291468,0.6093343662186208,0.42866828080672575,0.3678786508029968,4478]
["High","P17600-2","Isoform IB of Synapsin-1 [OS=Homo sapiens]",24,11,19,11,669,70,9.88,29.56,"","","","SYN1","","","","",420.2,401.6,472.6,369.8,372.7,368.1,1.1654961282189809,0.22094421183824747,0.045167938526614784,1.3451697302698213,0.14435991159058872,0.8405533925846226,2443]
["High","P17844","probable ATP-dependent RNA helicase DDX5 [OS=Homo sapiens]",56,38,292,29,614,69.1,8.92,601.5,"RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX5","ENSG00000108654","Ciliary landscape","Estrogen-dependent gene expression; mRNA Splicing - Major Pathway; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome; SUMOylation of transcription cofactors","Spliceosome; Transcriptional misregulation in cancer; Proteoglycans in cancer",12785.4,12782.2,12872,13380.2,14092.3,14029.1,0.9262197120111031,-0.11057363376667392,0.011262848098939997,1.9483517731394009,0.06523762459682753,1.1855018606800665,1348]
["High","P17858-1","ATP-dependent 6-phosphofructokinase, liver type [OS=Homo sapiens]",44,26,65,22,780,85,7.5,161.78,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;other cell component","kinase activity;other molecular function","PFKL","ENSG00000141959; ENSPTRG00000022972","Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Insulin signaling; Glycolysis and gluconeogenesis","Neutrophil degranulation; Glycolysis","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Galactose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway; AMPK signaling pathway; Thyroid hormone signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer",3042.4,3292.6,2985.4,2956.6,3303.1,3017.5,1.0046565774155993,0.006702428040491163,0.9243761523530857,0.0341512672550844,0.958503186928671,0.0184064387971496,7530]
["High","P18085","ADP-ribosylation factor 4 [OS=Homo sapiens]",79,10,76,6,180,20.5,7.14,177.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARF4","ENSG00000168374","VEGFA-VEGFR2 signaling pathway","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; VxPx cargo-targeting to cilium","Endocytosis",2255.7,2285.4,2186.1,1607.9,1892.5,1693.3,1.2952615668983576,0.37324346714899526,0.004611337799106244,2.3361730627915747,0.041148943469053206,1.3856413111552524,875]
["High","P18583-5","Isoform D of Protein SON [OS=Homo sapiens]",23,38,165,8,2459,266.9,5.73,368.2,"","","","SON","","","","",5024.2,5089.8,5230.8,5832.7,5505.7,5583.1,0.9068226812043849,-0.14110761905803887,0.010562272378977838,1.9762426371541149,0.06271499827761137,1.2026285853212562,1315]
["High","P18669","Phosphoglycerate mutase 1 [OS=Homo sapiens]",81,19,241,19,254,28.8,7.18,546.26,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","PGAM1","ENSG00000171314","Cori cycle; Metabolic reprogramming in colon cancer; Glycolysis and gluconeogenesis","Neutrophil degranulation; Glycolysis; Gluconeogenesis","Glycolysis / Gluconeogenesis; Glycine, serine and threonine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Glucagon signaling pathway; Central carbon metabolism in cancer",8751.3,8900.2,8992.8,9879.3,9036.1,9443.6,0.9395359497866638,-0.08997972985015065,0.08711726252686781,1.0598957798105264,0.2202757726067953,0.6570332668155897,3088]
["High","P19012","Keratin, type I cytoskeletal 15 [OS=Homo sapiens]",12,8,31,1,456,49.2,4.77,73.53,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","KRT15","ENSG00000171346","","Formation of the cornified envelope","Estrogen signaling pathway; Staphylococcus aureus infection",44.6,35.2,32.3,32.5,37.6,33,1.08729388942774,0.12074194543731827,0.5001365098815779,0.3009114408705566,0.6699375311640693,0.17396569153136618,5829]
["High","P19086","guanine nucleotide-binding protein G(z) subunit alpha [OS=Homo sapiens]",4,1,1,1,355,40.9,7.61,3.2,"signal transduction","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus","signal transduction activity or receptor binding;other molecular function","GNAZ","ENSG00000128266","Corticotropin-releasing hormone signaling pathway; G protein signaling pathways; Purinergic signaling; Calcium regulation in cardiac cells","G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; ADORA2B mediated anti-inflammatory cytokines production","Long-term depression",23.6,32.9,28.7,20.7,29.7,29.8,{"$f":"AVERAGE(T1474:V1474)/AVERAGE(W1474:Y1474)","v":1.0623441396508728},{"$f":"LOG(Z1474,2)","v":0.08725119377091796},{"$f":"TTEST(T1474:V1474,W1474:Y1474,2,2)","v":0.7011769190033164},{"$f":"-LOG10(AB1474)","v":0.1541723882349404},{"$f":"AB1474*7808/AF1474","v":0.8185988910852114},{"$f":"-LOG10(AD1474)","v":0.08692884800726497},6688]
["High","P19367-1","Hexokinase-1 [OS=Homo sapiens]",46,39,161,36,917,102.4,6.8,376.43,"other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion","kinase activity;other molecular function","HK1","ENSG00000156515","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Glycolysis and gluconeogenesis; Glucuronidation","Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)","Glycolysis / Gluconeogenesis; Fructose and mannose metabolism; Galactose metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Neomycin, kanamycin and gentamicin biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of nucleotide sugars; HIF-1 signaling pathway; Insulin signaling pathway; Type II diabetes mellitus; Carbohydrate digestion and absorption; Shigellosis; Central carbon metabolism in cancer",8099.1,8378.3,8417.8,7989.1,8780.4,8633.2,0.9800218087053737,-0.029114240597264217,0.5549087875684832,0.2557783976181947,0.711332755431738,0.14792719246098063,6091]
["High","P19793","retinoic acid receptor RXR-alpha [OS=Homo sapiens]",11,4,5,4,462,50.8,7.8,7.86,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RXRA","ENSG00000186350","Vitamin D metabolism; Energy metabolism; Nuclear receptors; Adipogenesis; Liver X receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Vitamin D receptor pathway; PPAR-alpha pathway; Farnesoid X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Prion disease pathway; PI3K/AKT/mTOR - VitD3 signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Vitamins A and D - action mechanisms; Nonalcoholic fatty liver disease; Vitamin D in inflammatory diseases; Small cell lung cancer; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Vitamin A and carotenoid metabolism","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Regulation of pyruvate dehydrogenase (PDH) complex; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; SUMOylation of intracellular receptors; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Endogenous sterols; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Signaling by Retinoic Acid; Nuclear Receptor transcription pathway; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Recycling of bile acids and salts; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; Transcriptional regulation of granulopoiesis; RORA activates gene expression; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis","PPAR signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation; Thyroid hormone signaling pathway; Adipocytokine signaling pathway; Parathyroid hormone synthesis, secretion and action; Non-alcoholic fatty liver disease; Bile secretion; Hepatitis C; Pathways in cancer; Transcriptional misregulation in cancer; Chemical carcinogenesis; Thyroid cancer; Small cell lung cancer; Non-small cell lung cancer; Gastric cancer; Lipid and atherosclerosis",140.8,151.7,147.6,166.2,179,182.2,0.8344709897610924,-0.2610661994700138,0.007539095443886066,2.1226807585460095,0.05260523433946595,1.2789710404157242,1119]
["High","P20073-1","Annexin A7 [OS=Homo sapiens]",36,16,55,16,488,52.7,5.68,88.88,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ANXA7","ENSG00000138279","","","Amyotrophic lateral sclerosis",1810.6,1911.4,1881.8,1712.9,1877,1756.7,1.048105337971795,0.06778371967355372,0.20994960859607573,0.6778849306698755,0.3873550434589223,0.41189078503836957,4232]
["High","P20337","Ras-related protein Rab-3B [OS=Homo sapiens]",48,8,31,6,219,24.7,5.02,55.97,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3B","ENSG00000169213","Intracellular trafficking proteins involved in CMT neuropathy","RAB geranylgeranylation","",761.2,835,814.6,818.4,927.2,886.7,0.9158530562625841,-0.12681195072134807,0.12853154494220542,0.8909902722311027,0.28285634242072716,0.5484340787321561,3548]
["High","P20340-2","Isoform 2 of Ras-related protein Rab-6A [OS=Homo sapiens]",53,14,46,10,208,23.5,5.54,85.21,"","","","RAB6A","","","","",3231,3827.6,3656.5,3454.7,4103,3765.6,0.9462877429724552,-0.07964915631394326,0.475737096198017,0.3226329826016307,0.6500796722285819,0.1870334139897195,5714]
["High","P20936-1","ras GTPase-activating protein 1 [OS=Homo sapiens]",10,8,17,8,1047,116.3,6.54,37.16,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RASA1","ENSG00000145715","PDGF pathway; T cell receptor and co-stimulatory signaling; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; EPO receptor signaling","Regulation of RAS by GAPs; VEGFR2 mediated cell proliferation; EPHB-mediated forward signaling; Downstream signal transduction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases","MAPK signaling pathway; Ras signaling pathway; Axon guidance",573,564.5,585.2,553.1,540.2,550.5,1.0479985399683658,0.06763670696900304,0.02155780826905211,1.6663953949250643,0.09228254767804764,1.0348804242588263,1824]
["High","P21283","V-type proton ATPase subunit C 1 [OS=Homo sapiens]",37,14,26,14,382,43.9,7.46,50.96,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity","ATP6V1C1","ENSG00000155097","Proximal tubule transport","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",1803.3,1767.8,1808.9,1677,1686.1,1693.7,1.0639139376680904,0.08938145279288637,1.4306133764601697E-3,2.844477718550864,0.025045357047984315,1.6012727726043707,446]
["High","P21709","Ephrin type-A receptor 1 [OS=Homo sapiens]",13,9,18,9,976,108.1,6.64,29.06,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","EPHA1","ENSG00000146904; ENSG00000284816","","EPHA-mediated growth cone collapse; EPH-ephrin mediated repulsion of cells; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","Axon guidance",1173.1,1136.4,1134.5,1169.3,1204.4,1237.1,0.953805250913925,-0.06823336977028656,0.07513862730582772,1.1241367432485436,0.1991454181954864,0.7008296810965203,2946]
["High","P21926","CD9 antigen [OS=Homo sapiens]",30,8,35,8,228,25.4,7.15,61.17,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","CD9","ENSG00000010278","Vitamin D receptor pathway","Platelet degranulation ; Uptake and function of diphtheria toxin; Acrosome Reaction and Sperm:Oocyte Membrane Binding","Hematopoietic cell lineage",1354.2,1382,1432.3,1847.8,1773.9,1827.6,0.7649606371460556,-0.38654258244841455,1.7714433967718925E-4,3.7516727201935556,0.010977325430154712,1.9595034606524833,126]
["High","P22087","rRNA 2'-O-methyltransferase fibrillarin [OS=Homo sapiens]",53,19,122,16,321,33.8,10.18,265.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","FBL","ENSG00000105202; ENSG00000280548","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",4934.3,5393.6,5336.5,5179.4,5688.8,5685.7,0.9462664387244094,-0.07968163679276294,0.25367051436321625,0.595730010482442,0.43665330161992777,0.35986325170865685,4536]
["High","P22307-1","Non-specific lipid-transfer protein [OS=Homo sapiens]",30,13,48,13,547,59,6.89,87.75,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","SCP2","ENSG00000116171","PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; DNA damage response (only ATM dependent)","TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism","Primary bile acid biosynthesis; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome",1839.4,1793.4,2067.5,2093,1924.5,1869.9,0.9682202670109048,-0.046592801545747235,0.5949666418226984,0.22550738331086556,0.7415003255150246,0.12988865398239896,6265]
["High","P22626","heterogeneous nuclear ribonucleoproteins A2/B1 [OS=Homo sapiens]",91,30,462,27,353,37.4,8.95,1127.2,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPA2B1","ENSG00000122566","mRNA processing","mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Processing of Capped Intron-Containing Pre-mRNA","Amyotrophic lateral sclerosis",19665.5,19799.8,20315,22637.4,22507.7,23059.2,0.8764887257841515,-0.1901925610730037,4.0855037057017343E-4,3.3887543912439635,0.014768339321351454,1.830668337736259,216]
["High","P23142","Fibulin-1 [OS=Homo sapiens]",15,8,12,8,703,77.2,5.22,29.01,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;extracellular matrix","signal transduction activity or receptor binding;enzyme regulator activity;extracellular structural activity;other molecular function","FBLN1","ENSG00000077942","","Molecules associated with elastic fibres","",935.1,739.8,688.5,237.6,250.1,258.9,3.165550495579963,1.6624564090321297,2.0247351361827462E-3,2.6936317805567986,0.028954454108635317,1.5382846186029004,546]
["High","P23368-1","NAD-dependent malic enzyme, mitochondrial [OS=Homo sapiens]",41,14,61,14,584,65.4,7.61,109.36,"other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","ME2","ENSG00000082212","TCA cycle in senescence","Citric acid cycle (TCA cycle)","Pyruvate metabolism; Carbon metabolism",1416.3,1560.7,1406.5,1553.6,1693.5,1631.1,0.8985896437210448,-0.15426566004402573,0.06208338562634388,1.2070246074917128,0.17550582004724583,0.7557084770756899,2762]
["High","P23458","Tyrosine-protein kinase JAK1 [OS=Homo sapiens]",4,4,6,4,1154,133.2,7.55,12.61,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK1","ENSG00000162434","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-17 signaling pathway; Type III interferon signaling; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Overview of interferons-mediated signaling pathway; Measles virus infection; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; TGF-beta receptor signaling in skeletal dysplasias; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; IL-2 signaling pathway; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; Malignant pleural mesothelioma; TGF-beta receptor signaling; Interferon type I signaling pathways; Type II interferon signaling (IFNG)","Potential therapeutics for SARS; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Interleukin-4 and Interleukin-13 signaling; Interleukin-6 signaling; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; IL-6-type cytokine receptor ligand interactions; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-27 signaling; ISG15 antiviral mechanism; Interleukin-10 signaling; Interleukin-7 signaling; Regulation of IFNA signaling; Interleukin-2 signaling; Other interleukin signaling; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling","EGFR tyrosine kinase inhibitor resistance; PI3K-Akt signaling pathway; Necroptosis; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; NOD-like receptor signaling pathway; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Pancreatic cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer",181.4,209.9,172.9,146.6,144.7,162,1.2446503419369073,0.31574050469958637,0.04125286317594651,1.3845459036386198,0.13677382406700228,0.8639970104448993,2355]
["High","P23511","Nuclear transcription factor Y subunit alpha [OS=Homo sapiens]",5,1,7,1,347,36.9,8.94,6.86,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFYA","ENSG00000001167","Sterol regulatory element-binding proteins (SREBP) signaling; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways","ATF4 activates genes in response to endoplasmic reticulum  stress; PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF6 (ATF6-alpha) activates chaperone genes","Antigen processing and presentation; Spinocerebellar ataxia; Tuberculosis",95.7,110.5,100,98.9,93.4,93.2,1.0725043782837127,0.10098353724958262,0.2220330110849273,0.6535824513771982,0.4013041089238686,0.39652639353347485,4320]
["High","P24385","G1/S-specific cyclin-D1 [OS=Homo sapiens]",16,3,3,2,295,33.7,5.02,9.57,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCND1","ENSG00000110092","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Leptin signaling pathway; IL-7 signaling pathway; Glioblastoma signaling pathways; Spinal cord injury; Retinoblastoma gene in cancer; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Mammary gland development pathway - Puberty (Stage 2 of 4); Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Bladder cancer; Mesodermal commitment pathway; Vitamin D receptor pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; Focal adhesion; Copper homeostasis; Photodynamic therapy-induced NF-kB survival signaling; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; Non-small cell lung cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Wnt signaling; Acute viral myocarditis; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; G1 to S cell cycle control; Hippo-Merlin signaling dysregulation; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Melanoma; FGF23 signaling in hypophosphatemic rickets and related disorders; EGFR tyrosine kinase inhibitor resistance; Influence of laminopathies on Wnt signaling; Development of ureteric collection system; Malignant pleural mesothelioma; Notch signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)","Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Cyclin D associated events in G1; Interleukin-4 and Interleukin-13 signaling; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Transcriptional Regulation by VENTX; RMTs methylate histone arginines; Transcriptional regulation by RUNX2; RUNX3 regulates WNT signaling; RUNX3 regulates p14-ARF; PTK6 Regulates Cell Cycle; Regulation of RUNX1 Expression and Activity","Endocrine resistance; FoxO signaling pathway; Cell cycle; p53 signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Cellular senescence; Wnt signaling pathway; Hedgehog signaling pathway; Apelin signaling pathway; Hippo signaling pathway; Focal adhesion; Tight junction; JAK-STAT signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Alcoholic liver disease; Hepatitis C; Measles; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Viral myocarditis",59.7,53.9,42.3,47.3,48.7,46.1,1.0971147079521462,0.13371437345500412,0.42387749364792215,0.37275964227585234,0.604941595760003,0.21828655239468622,5471]
["Low","P24864-1","G1/S-specific cyclin-E1 [OS=Homo sapiens]",2,1,1,1,410,47,6.04,0,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNE1","ENSG00000105173","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; ATM signaling pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Malignant pleural mesothelioma; ID signaling pathway; DNA damage response","CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; G1/S-Specific Transcription; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); RHOBTB3 ATPase cycle; DNA Damage/Telomere Stress Induced Senescence; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle","Cell cycle; Oocyte meiosis; p53 signaling pathway; PI3K-Akt signaling pathway; Cellular senescence; Cushing syndrome; Hepatitis B; Measles; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Prostate cancer; Small cell lung cancer; Gastric cancer",24.3,23.3,18.8,26.3,29.2,30.4,0.7729918509895227,-0.37147488979153875,0.035550619557929285,1.4491528262072026,0.12441920103465345,0.9051125918324051,2231]
["High","P25205","DNA replication licensing factor mcm3 [OS=Homo sapiens]",65,46,326,46,808,90.9,5.77,658.4,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3","ENSG00000112118","Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Unwinding of DNA","DNA replication; Cell cycle",11030.4,11078.1,11218.2,12050.6,12015.6,12105.2,0.9213549931714006,-0.11817096874282416,1.0725803672978975E-4,3.969570156703756,0.00881548158722314,2.0547539573339684,95]
["High","P25490","Transcriptional repressor protein YY1 [OS=Homo sapiens]",28,9,22,9,414,44.7,6.25,49.12,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","YY1","ENSG00000100811","Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Malignant pleural mesothelioma","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; UCH proteinases; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors","",950.3,942.4,939,1069.5,991.2,1014.3,0.9208780487804877,-0.11891798099073612,0.025916571206454308,1.5864224566832885,0.1029280712004045,0.9874661655207698,1966]
["High","P25788-1","Proteasome subunit alpha type-3 [OS=Homo sapiens]",40,13,55,13,255,28.4,5.33,117.92,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMA3","ENSCANG00000039836; ENSCATG00000039369; ENSCJAG00000018732; ENSCSAG00000014435; ENSG00000100567; ENSGGOG00000015814; ENSMFAG00000002833; ENSMLEG00000041984; ENSMMUG00000003509; ENSMNEG00000035144; ENSNLEG00000013092; ENSPANG00000007163; ENSPPAG00000035468; ENSPPYG00000005855; ENSPTRG00000006390; ENSRROG00000040700; ENSSBOG00000021565","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",3672.1,3944.2,3891.5,3829.2,4265.8,4061.2,0.9466609631299253,-0.0790802630570017,0.22597329397546453,0.6459428837040039,0.40645000676351695,0.3909928648840684,4341]
["High","P26358-1","DNA (cytosine-5)-methyltransferase 1 [OS=Homo sapiens]",46,63,199,1,1616,183.1,7.75,415.46,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT1","ENSG00000130816","Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency","NoRC negatively regulates rRNA expression; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer",269.8,269.6,295.4,303.6,264.5,270.6,0.9953499463455349,-0.006724255566552004,0.934502758038978,0.029419412530904684,0.9657971588045453,0.015114076547313473,7555]
["High","P26572","alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [OS=Homo sapiens]",5,2,2,2,445,50.8,9.16,6.61,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MGAT1","ENSG00000131446","","Maturation of spike protein; Maturation of spike protein; N-glycan trimming and elongation in the cis-Golgi","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways",193,210.3,231.1,165.9,213.8,199.8,1.0947368421052632,0.13058410981014443,0.36647949048615536,0.4359503250281008,0.5503888943481249,0.2593303378030448,5199]
["High","P26641","elongation factor 1-gamma [OS=Homo sapiens]",72,29,252,29,437,50.1,6.67,477.94,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","EEF1G","ENSG00000254772","Translation factors","Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation","Legionellosis",9674.9,9761,9727.7,9422.1,9798.8,9524,1.0145660621536343,0.020862807370035524,0.2925750380907517,0.5337627297551014,0.47921667661266815,0.31946807702350805,4767]
["High","P27348","14-3-3 protein theta [OS=Homo sapiens]",69,21,560,15,245,27.7,4.78,1098.18,"transport;signal transduction;other biological processes","cytosol;other cell component","other molecular function","YWHAQ","ENSG00000134308","Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria","Cell cycle; Oocyte meiosis; PI3K-Akt signaling pathway; Hippo signaling pathway; Hepatitis C; Hepatitis B; Viral carcinogenesis",15416.5,15528,15229.7,14735.5,15148.2,13963.2,1.0530778686748663,0.0746121187924159,0.09615595733964645,1.0170238038894905,0.23345326956093268,0.6318000393072688,3216]
["High","P27635","60S ribosomal protein L10 [OS=Homo sapiens]",46,11,154,11,214,24.6,10.08,304.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPL10","ENSG00000147403","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",3765.8,3952.1,4456.2,4232.8,3773.5,3761,1.0345703772318204,0.04903178867771443,0.6271110828503651,0.20265552392848468,0.7654343184142021,0.11609206998741195,6397]
["High","P27816-5","Isoform 5 of Microtubule-associated protein 4 [OS=Homo sapiens]",42,29,83,1,809,85.2,7.71,105.85,"","","","MAP4","","","","",116.9,137.5,106.1,115,140.4,126.1,0.944954128440367,-0.08168379759370799,0.584481875703087,0.2332289514040699,0.7331139735726431,0.13482850251320846,6225]
["High","P28070","Proteasome subunit beta type-4 [OS=Homo sapiens]",48,8,60,8,264,29.2,5.97,122.95,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","other molecular function","PSMB4","ENSG00000159377","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of RUNX2 expression and activity; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint; UCH proteinases; Regulation of RUNX3 expression and activity; Regulation of ornithine decarboxylase (ODC); ROS sensing by NFE2L2; Regulation of PTEN stability and activity; Regulation of RAS by GAPs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",1037.2,1202.1,1065.1,1109.3,1254.4,1162.5,0.9370994271453691,-0.09372596755833007,0.32712550839978094,0.48528558939585964,0.5143366833639729,0.2887524999557698,4966]
["Low","P28332-1","Alcohol dehydrogenase 6 [OS=Homo sapiens]",3,1,1,1,368,39.1,7.77,0,"","","","","","","","",76.4,79.6,89.8,76.6,95.3,93.8,0.9251035001881822,-0.11231331211784487,0.41096876170768065,0.386191188181288,0.5929128032914949,0.227009171448238,5412]
["High","P28799","Granulins [OS=Homo sapiens]",4,2,3,2,593,63.5,6.83,6.9,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GRN","ENSG00000030582","IL-18 signaling pathway","Neutrophil degranulation","",255.9,278.1,277.2,240.5,215.6,254.8,1.1410887607258404,0.19041101746220984,0.06923990201179747,1.1596435554090898,0.18869987954908013,0.7242283770538632,2865]
["High","P29084","transcription initiation factor iie subunit beta [OS=Homo sapiens]",41,10,40,9,291,33,9.66,62.58,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","GTF2E2","ENSG00000197265","Eukaryotic transcription initiation","RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors; Viral carcinogenesis",1247.2,1157.7,1168.8,1255.1,1085.8,1199.6,1.0093772066092361,0.013465413699538352,0.8561119551081017,0.06746943823595807,0.9176993609945164,0.03729957070020508,7284]
["High","P29353","SHC-transforming protein 1 [OS=Homo sapiens]",31,12,25,12,583,62.8,6.44,61.33,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","signal transduction activity or receptor binding;other molecular function","SHC1","ENSG00000160691","IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; IL-4 signaling pathway; p38 MAPK signaling pathway; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; EGF/EGFR signaling pathway; Fragile X syndrome; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Malignant pleural mesothelioma; EPO receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)","Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Interleukin receptor SHC signaling; RET signaling; RAF/MAP kinase cascade; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; Signaling by CSF3 (G-CSF); XBP1(S) activates chaperone genes; SHC1 events in EGFR signaling; Integrin signaling; Erythropoietin activates RAS; Signalling to RAS; Signal attenuation; Interleukin-2 signaling; Interleukin-15 signaling","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; ErbB signaling pathway; Ras signaling pathway; Chemokine signaling pathway; Phospholipase D signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Insulin signaling pathway; Estrogen signaling pathway; Prolactin signaling pathway; Relaxin signaling pathway; Growth hormone synthesis, secretion and action; Alcoholism; Bacterial invasion of epithelial cells; MicroRNAs in cancer; Glioma; Chronic myeloid leukemia; Breast cancer; Hepatocellular carcinoma; Gastric cancer",1096.7,1194.4,1197.6,1116.7,1218.1,1155,0.9996847956902976,-4.5481537812442474E-4,0.9938048508027143,0.002698887775925508,0.996484946072633,1.5292578134382408E-3,7787]
["High","P29401","Transketolase [OS=Homo sapiens]",70,36,535,36,623,67.8,7.66,1322.77,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","TKT","ENSG00000163931","Pentose phosphate metabolism; VEGFA-VEGFR2 signaling pathway; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways","Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",22598,23623.9,23406,23548.3,25163.1,25030.1,0.944215943532475,-0.08281125115215195,0.08582544580236837,1.0663839320442947,0.21743188865181445,0.6626767617680599,3082]
["High","P30043","flavin reductase (NADPH) [OS=Homo sapiens]",35,5,13,5,206,22.1,7.65,29.56,"other metabolic processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","BLVRB","ENSG00000090013","Nuclear receptors meta-pathway; NRF2 pathway; IL-10 anti-inflammatory signaling pathway","Cytoprotection by HMOX1; Heme degradation","Riboflavin metabolism; Porphyrin metabolism; Metabolic pathways",337,333.1,324.2,376,310.5,337.2,0.9712806486275276,-0.04203987660478856,0.6398295510356189,0.19393570555336778,0.7747811933136031,0.11082092969176659,6448]
["High","P30047","GTP cyclohydrolase 1 feedback regulatory protein [OS=Homo sapiens]",19,1,1,1,84,9.7,6.54,2.46,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","GCHFR","ENSG00000137880","","Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","",10.8,10.7,16.5,15.5,8,15.2,0.9819121447028423,-0.02633414781346262,0.943831543263977,0.025105512438535194,0.9708123685687172,0.012864699205652388,7591]
["High","P30153","serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [OS=Homo sapiens]",60,32,294,24,589,65.3,5.11,599.14,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP2R1A","ENSG00000105568","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Cyclin A/B1/B2 associated events during G2/M transition; Regulation of TP53 Degradation; Regulation of PLK1 Activity at G2/M Transition; Cyclin D associated events in G1; Spry regulation of FGF signaling; Negative regulation of MAPK pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; TGF-beta signaling pathway; Hippo signaling pathway; Tight junction; Dopaminergic synapse; Long-term depression; Chagas disease; Hepatitis C; Human papillomavirus infection",10196.2,9834.5,10085.5,10158.3,9932.1,10020.4,1.0001793376462929,2.5870633575204605E-4,0.9892540507820312,0.004692162716034525,0.994732212299562,0.002293818121976502,7765]
["High","P30291-1","Wee1-like protein kinase [OS=Homo sapiens]",10,6,9,6,646,71.6,6.77,14.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","WEE1","ENSG00000166483","Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control","Factors involved in megakaryocyte development and platelet production; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin A:Cdk2-associated events at S phase entry; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Polo-like kinase mediated events; G2/M DNA replication checkpoint; Cyclin E associated events during G1/S transition","Cell cycle; Human immunodeficiency virus 1 infection",220.4,243.4,232.7,241.2,256.2,272,0.905250844814141,-0.1436104768079995,0.09379139046289948,1.027837025651453,0.22942455411476165,0.6393601036715095,3192]
["High","P30566","adenylosuccinate lyase [OS=Homo sapiens]",32,16,44,16,484,54.9,7.11,87.55,"other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","ADSL","ENSG00000239900","Nucleotide metabolism","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of cofactors",2566.4,2587.9,2515.9,2867.9,2791.9,2843.1,0.9020687059709043,-0.14869077450137605,0.000852209519661369,3.0694536187939665,0.019803725980702288,1.7032530915251753,336]
["High","P30825","High affinity cationic amino acid transporter 1 [OS=Homo sapiens]",8,4,7,3,629,67.6,5.43,7.41,"transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC7A1","ENSG00000139514","VEGFA-VEGFR2 signaling pathway","Amino acid transport across the plasma membrane","MicroRNAs in cancer",359.4,360.3,383.5,425.9,405.8,422.5,0.8796045287832882,-0.18507306273134883,0.007419672026697065,2.12961529150584,0.052144733739379556,1.2827895457880725,1111]
["High","P31040","Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [OS=Homo sapiens]",34,15,42,15,664,72.6,7.39,113.53,"other metabolic processes;developmental processes","other membranes;mitochondrion;nucleus","other molecular function","SDHA","ENSG00000073578","Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)","Respiratory electron transport; Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Oxidative phosphorylation; Metabolic pathways; Carbon metabolism; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",1562.9,1596.6,1602.3,1464.3,1460,1546.5,1.0650890220989533,0.09097401859501907,0.03423754397824443,1.46549739688485,0.12162272219387285,0.9149852803136863,2198]
["High","P31350-1","ribonucleoside-diphosphate reductase subunit M2 [OS=Homo sapiens]",40,12,34,11,389,44.8,5.38,64.89,"cell organization and biogenesis;other metabolic processes;developmental processes","cytosol","other molecular function","RRM2","ENSG00000171848","Fluoropyrimidine activity; Retinoblastoma gene in cancer; Hepatitis C and hepatocellular carcinoma; Pyrimidine metabolism; Nucleotide metabolism; Orexin receptor pathway","G1/S-Specific Transcription; Transcriptional Regulation by E2F6; Interconversion of nucleotide di- and triphosphates","Purine metabolism; Pyrimidine metabolism; Glutathione metabolism; Drug metabolism; Metabolic pathways; p53 signaling pathway",878.9,975.4,858.1,835.3,916.2,845.7,1.0443554597258586,0.06261283518501168,0.4337596640618615,0.36275083611580355,0.6151099631302243,0.21104723851447962,5506]
["High","P31689-1","DnaJ homolog subfamily A member 1 [OS=Homo sapiens]",65,20,120,20,397,44.8,7.08,309.2,"stress response;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","Dnaja1; DNAJA1; LOC109263810; LOC111146318; LOC112809310","ENSCAFG00000001474; ENSCAFG00000001818; ENSCATG00000033398; ENSCJAG00000008022; ENSCPOG00000000462; ENSECAG00000010324; ENSFCAG00000008729; ENSG00000086061; ENSGGOG00000007030; ENSLCNG00005016649; ENSMFAG00000032081; ENSMLEG00000042863; ENSMMUG00000007740; ENSMNEG00000030895; ENSNLEG00000005268; ENSOCUG00000004833; ENSPANG00000025299; ENSPPAG00000027533; ENSPPYG00000019141; ENSPTRG00000020852; ENSRROG00000029815; ENSSSCG00000011000; ENSSSCG00070018491; ENSSSUG00005020902; ENSSTOG00000005200","VEGFA-VEGFR2 signaling pathway; Exercise-induced circadian regulation","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","Protein processing in endoplasmic reticulum",4181.4,4132.4,4164.6,4434.8,4219.3,4385.9,0.9569325153374232,-0.06351090812898907,0.04868110478082123,1.3126395743456296,0.15113402231755552,0.8206377590789404,2515]
["High","P31947-1","14-3-3 protein sigma [OS=Homo sapiens]",38,8,125,4,248,27.8,4.74,270.24,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","enzyme regulator activity;other molecular function","SFN","ENSG00000175793; ENSGGOG00000011493; ENSNLEG00000018582; ENSPPAG00000013397; ENSPTRG00000030723","miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; DNA damage response; Calcium regulation in cardiac cells","TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","Cell cycle; p53 signaling pathway; Aldosterone-regulated sodium reabsorption",272.6,270.7,263.8,310.7,313.3,327,0.8486855941114615,-0.23669790603855004,1.1058650183741708E-3,2.956297879679413,0.022311612567094383,1.6514690400396892,387]
["High","P32322","Pyrroline-5-carboxylate reductase 1, mitochondrial [OS=Homo sapiens]",39,9,34,8,319,33.3,7.61,98.14,"other metabolic processes;stress response;other biological processes","mitochondrion","other molecular function","PYCR1","ENSG00000183010","Amino acid metabolism; Metabolic reprogramming in colon cancer","Glutamate and glutamine metabolism","Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids",1372.2,1485,1401,1488.3,1632.5,1603.7,0.9013017250502698,-0.14991794293925073,0.048913571717782156,1.3105706234046823,0.15131425038527854,0.8201201693181437,2524]
["High","P32519-1","ETS-related transcription factor Elf-1 [OS=Homo sapiens]",9,4,4,4,619,67.5,5.21,8.15,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ELF1","ENSG00000120690; ENSGGOG00000010760","","RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX1 regulates transcription of genes involved in BCR signaling","",115.6,117.6,113.3,86.8,91.6,97.1,1.2577132486388385,0.3308030335660561,1.8346812287269104E-3,2.7364393824369873,0.0280886098703916,1.5514697538762883,510]
["High","P33897","ATP-binding cassette sub-family D member 1 [OS=Homo sapiens]",9,6,10,6,745,82.9,8.95,17.78,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ABCD1","ENSG00000101986","Vitamin D receptor pathway","Class I peroxisomal membrane protein import; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids; Linoleic acid (LA) metabolism; ABC transporters in lipid homeostasis; Defective ABCD1 causes ALD","ABC transporters; Peroxisome",465.2,459.1,452.8,445.7,452.7,420.7,1.0439693730573876,0.06207938816608182,0.1351849223514666,0.8690717440801302,0.2921461039912126,0.5343999009895171,3613]
["Low","P34741","syndecan-2 [OS=Homo sapiens]",5,1,1,1,201,22.1,4.86,0,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SDC2","ENSG00000169439","miRNA targets in ECM and membrane receptors","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cell surface interactions at the vascular wall; Syndecan interactions; EPHB-mediated forward signaling; A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Cell adhesion molecules; Malaria; Proteoglycans in cancer; Fluid shear stress and atherosclerosis",130.3,137.8,161.9,164.3,151.4,182.9,0.8624147613317288,-0.21354622301467818,0.15845229319941806,0.800101471105133,0.3224382343760897,0.49155346564481395,3837]
["High","P34897-1","Serine hydroxymethyltransferase, mitochondrial [OS=Homo sapiens]",66,29,163,27,504,56,8.53,376.49,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","HEL-S-51e; SHMT2","ENSG00000182199","Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling","RHOG GTPase cycle; Metabolism of folate and pterines","Glycine, serine and threonine metabolism; Glyoxylate and dicarboxylate metabolism; One carbon pool by folate; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors; Antifolate resistance",5953.7,6157,6007.8,6007.4,6144,6190,0.9878471654290294,-0.017640242078981343,0.4154325011014033,0.3814995297151233,0.596926199595097,0.22407935913835986,5434]
["High","P35222","Catenin beta-1 [OS=Homo sapiens]",38,22,85,20,781,85.4,5.86,241.42,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CTNNB1","ENSG00000168036","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Heart development; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Gastric cancer network 2; Brain-derived neurotrophic factor (BDNF) signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Endoderm differentiation; Ectoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Focal adhesion; Ectoderm differentiation; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; OSX and miRNAs in tooth development; Wnt signaling pathway and pluripotency; PTF1A related regulatory pathway; Wnt signaling in kidney disease; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Genes controlling nephrogenesis; GDNF/RET signaling axis; Mammalian disorder of sexual development; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; 1q21.1 copy number variation syndrome; 7q11.23 copy number variation syndrome; Development of ureteric collection system; Malignant pleural mesothelioma; Alzheimer's disease; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response (only ATM dependent)","Deactivation of the beta-catenin transactivating complex; InlA-mediated entry of Listeria monocytogenes into host cells; RHO GTPases activate IQGAPs; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Myogenesis; Transcriptional Regulation by VENTX; Ca2+ pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; Apoptotic cleavage of cell adhesion  proteins; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production","Rap1 signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Leukocyte transendothelial migration; Melanogenesis; Thyroid hormone signaling pathway; Cushing syndrome; Alcoholic liver disease; Alzheimer disease; Pathways of neurodegeneration; Bacterial invasion of epithelial cells; Salmonella infection; Hepatitis C; Human cytomegalovirus infection; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Proteoglycans in cancer; Colorectal cancer; Endometrial cancer; Prostate cancer; Thyroid cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Arrhythmogenic right ventricular cardiomyopathy; Fluid shear stress and atherosclerosis",3511.5,3497.5,3479.9,3738.8,3778,3777.2,0.9287143616079334,-0.10669315000920034,7.1155915740996059E-5,4.147788987823262,0.007610758768571194,2.118572043285082,73]
["High","P35249","replication factor C subunit 4 [OS=Homo sapiens]",61,19,43,19,363,39.7,8.02,86.27,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC4","ENSG00000163918","Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","Activation of ATR in response to replication stress; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",1726.4,1773.7,1822.3,2032.2,1909.8,1940.2,0.9048315256196662,-0.14427889913299563,0.015445437155074319,1.811199795271255,0.07642457117035506,1.116766989486021,1578]
["High","P35250-1","Replication factor C subunit 2 [OS=Homo sapiens]",57,17,59,17,354,39.1,6.44,147.72,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC2","ENSG00000049541","DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Dual Incision in GG-NER; Termination of translesion DNA synthesis; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",2090.9,2040.9,2100.3,1995.2,2178.1,2034.7,1.0038820876288659,5.5898254808654495E-3,0.8974874551019327,0.04697161318761901,0.9417527280521288,0.026063113066537205,7441]
["High","P35555","Fibrillin-1 [OS=Homo sapiens]",3,8,10,5,2871,312,4.93,18.2,"","extracellular matrix","extracellular structural activity;other molecular function","","","","","",259.4,193.8,219.7,85.7,78.5,79.1,2.7657213316892726,1.4676558008689995,1.7319886282766517E-3,2.7614549637579984,0.02720999438548108,1.565271547832695,497]
["High","P35610","sterol O-acyltransferase 1 [OS=Homo sapiens]",13,6,13,6,550,64.7,8.94,16.73,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","other molecular function","SOAT1","ENSG00000057252","Statin inhibition of cholesterol production; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","LDL clearance","Steroid biosynthesis; Cholesterol metabolism",289.2,344.3,341.5,295.8,287.5,312.2,1.0887772194304857,0.1227087866510117,0.24232646319209916,0.615599156268006,0.42451986192593905,0.3721019856955469,4457]
["High","P35611-4","Isoform 4 of Alpha-adducin [OS=Homo sapiens]",43,22,80,2,662,73.3,6.16,141.49,"","","","ADD1","","","","",35.1,40.2,38.3,53,39.1,43,0.840858623242043,-0.2500648398210024,0.17859130336098075,0.7481396932318802,0.3492213615433352,0.4568991987675824,3993]
["High","P35813","Protein phosphatase 1A [OS=Homo sapiens]",36,12,35,11,382,42.4,5.36,68.31,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","PPM1A","ENSG00000100614","TGF-beta signaling pathway; MAPK signaling pathway","Downregulation of SMAD2/3:SMAD4 transcriptional activity; Energy dependent regulation of mTOR by LKB1-AMPK","MAPK signaling pathway",1328.1,1383.4,1311.3,1368,1452.5,1480.3,0.935360863095238,-0.09640502939717494,0.08237951794243994,1.0841807537191355,0.2122135519942498,0.6732268854281224,3031]
["High","P36405","ADP-ribosylation factor-like protein 3 [OS=Homo sapiens]",59,9,46,9,182,20.4,7.24,88.28,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","ARL3","ENSG00000138175","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","Trafficking of myristoylated proteins to the cilium","",1402.3,1373.3,1490.3,1294.9,1306.8,1231.3,1.1129402556744064,0.1543761486945218,0.026932949577012193,1.5697160819812155,0.1050411939547009,0.9786403504658799,2002]
["High","P36543","V-type proton ATPase subunit E 1 [OS=Homo sapiens]",54,13,38,13,226,26.1,8,79.95,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V1E1","ENSG00000131100","VEGFA-VEGFR2 signaling pathway; Proximal tubule transport","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",1944.1,1919.7,1943.7,1878.1,1810.7,1831.6,1.052007100934715,0.07314444269934485,0.011220023232855468,1.9500062438026309,0.06508613774304271,1.1865114990319534,1346]
["High","P36915-1","Guanine nucleotide-binding protein-like 1 [OS=Homo sapiens]",26,13,33,13,607,68.6,5.8,68.26,"stress response;signal transduction;other biological processes","non-structural extracellular","other molecular function","GNL1","ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986","","","",901.8,941.8,882.6,870.1,877.6,903.9,{"$f":"AVERAGE(T1858:V1858)/AVERAGE(W1858:Y1858)","v":1.0281339568562375},{"$f":"LOG(Z1858,2)","v":0.04002824731551581},{"$f":"TTEST(T1858:V1858,W1858:Y1858,2,2)","v":0.28628026990289757},{"$f":"-LOG10(AB1858)","v":0.5432085820083126},{"$f":"AB1858*7808/AF1858","v":0.472374545097596},{"$f":"-LOG10(AD1858)","v":0.32571351330556997},4732]
["High","P36955","Pigment epithelium-derived factor [OS=Homo sapiens]",5,2,4,2,418,46.3,6.38,8.18,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other cell component","enzyme regulator activity","SERPINF1","ENSG00000132386","lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Type I collagen synthesis in the context of osteogenesis imperfecta; GPR143 in melanocytes and retinal pigment epithelium cells; Malignant pleural mesothelioma","","Wnt signaling pathway",180.8,158.7,146.1,72.6,92.8,85.1,1.9385229540918167,0.9549578181731118,2.606058697112665E-3,2.5840158067565686,0.031353014340609685,1.5037206988983025,649]
["High","P37837","Transaldolase [OS=Homo sapiens]",44,17,161,17,337,37.5,6.81,329.5,"other metabolic processes","cytosol;other cell component","other molecular function","TALDO1","ENSG00000177156","Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of  Fru(6)P, E4P to SH7P, GA3P","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",9136.6,9035.9,9054.4,9028.6,9062,8986.8,1.0055212095696042,0.00794351288958182,0.2581094737205322,0.588196054700449,0.4414718008345927,0.35509703191213127,4565]
["High","P38159-2","Isoform 2 of RNA-binding motif protein, X chromosome [OS=Homo sapiens]",67,34,266,11,378,40.8,10.04,391.98,"","","","RBMX","","","","",13077.2,12785.6,12781.1,16167.5,15243.1,16476.9,0.8069725920125295,-0.3094084201935851,1.3005147035625158E-3,2.8858847333258812,0.023949100956170102,1.6207107852599782,424]
["High","P39023","60S ribosomal protein L3 [OS=Homo sapiens]",47,22,295,22,403,46.1,10.18,487.69,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","other molecular function","RPL3","ENSG00000100316","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",11070.5,11853.9,11504.5,11173.9,12157.3,11959.9,0.9755689111419028,-0.03568431098045964,0.48751121711480605,0.312015387196176,0.6601608711814786,0.1803502205897296,5766]
["High","P40123","Adenylyl cyclase-associated protein 2 [OS=Homo sapiens]",32,14,33,13,477,52.8,6.37,71.97,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","cytoskeletal activity;other molecular function","CAP2","ENSG00000112186","Ectoderm differentiation; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway","Role of ABL in ROBO-SLIT signaling","",1317.5,1298.6,1278.9,1442.4,1503.2,1469.9,0.8821198052315706,-0.18095348595760596,1.1316506298968982E-3,2.9462876305037016,0.02225674588976066,1.652538332608181,397]
["High","P40429","60S ribosomal protein L13a [OS=Homo sapiens]",42,12,97,12,203,23.6,10.93,170.49,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","RPL13A","ENSG00000142541","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",4924.5,5442.2,5248.4,4908,5689,5216,0.9874849807120725,-0.01816928941101185,0.8207820022861793,0.08577217512881684,0.8971952784334996,0.04711302059472376,7143]
["High","P40937-1","Replication factor C subunit 5 [OS=Homo sapiens]",68,20,58,20,340,38.5,7.2,116.44,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC5","ENSG00000111445","Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","HDR through Homologous Recombination (HRR); Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Termination of translesion DNA synthesis; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",2702.5,2960.7,2641,2662.9,3022,2883.7,0.9691431505730228,-0.04521831534763801,0.5717337925050792,0.24280613791557662,0.7228137065867323,0.1409736205846209,6176]
["Medium","P41217","OX-2 membrane glycoprotein [OS=Homo sapiens]",4,1,1,1,278,31.2,8.51,2.55,"cell adhesion;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CD200","ENSG00000091972","Vitamin D receptor pathway","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","",128.9,124.2,142,151.9,170.2,138.5,0.8577941815023883,-0.2212965648151749,0.10894695688797541,0.9627848959842011,0.25415531502280014,0.5949008036833429,3347]
["High","P41225","Transcription factor SOX-3 [OS=Homo sapiens]",29,7,13,7,446,45.2,9.77,44.52,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SOX3","ENSG00000134595","","Deactivation of the beta-catenin transactivating complex","",427.9,427.6,435.9,228.8,249,232.7,1.8175932441942295,0.8620293776172069,8.827281841509751E-6,5.054173006837565,0.004594894441233875,2.3377244612346106,15]
["High","P41273","Tumor necrosis factor ligand superfamily member 9 [OS=Homo sapiens]",11,2,2,2,254,26.6,7.02,0,"cell-cell signaling;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding","TNFSF9","ENSG00000125657","Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling","TNFs bind their physiological receptors","Cytokine-cytokine receptor interaction",13.7,21.7,17.7,19.7,15.6,18.9,{"$f":"AVERAGE(T1922:V1922)/AVERAGE(W1922:Y1922)","v":0.9797047970479704},{"$f":"LOG(Z1922,2)","v":-0.029580990549718026},{"$f":"TTEST(T1922:V1922,W1922:Y1922,2,2)","v":0.8957903423408179},{"$f":"-LOG10(AB1922)","v":0.04779362406447268},{"$f":"AB1922*7808/AF1922","v":0.9404774765358487},{"$f":"-LOG10(AD1922)","v":0.026651600893321113},7437]
["High","P42167","Lamina-associated polypeptide 2, isoforms beta/gamma [OS=Homo sapiens]",52,19,144,6,454,50.6,9.38,338.34,"","other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","TMPO","ENSG00000120802","Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RHOC GTPase cycle; RHOJ GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle","",2688.1,2913.3,2969.5,3044.2,2987.5,3001.7,0.9488011158589236,-0.0758223882884492,0.1534119071860104,0.8141409309705466,0.3148896349391086,0.5018416345772875,3804]
["High","P42285","Superkiller viralicidic activity 2-like 2 [OS=Homo sapiens]",36,35,115,34,1042,117.7,6.52,206.2,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus","other molecular function","MTREX","ENSG00000039123","","mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol","RNA degradation",4116.9,4282.6,4275.9,4808.7,5147.4,5068.4,0.8436487071117176,-0.24528570497146882,2.4912790623225316E-3,2.603577621946173,0.031073333735805633,1.507612150497967,626]
["High","P42575-1","caspase-2 [OS=Homo sapiens]",3,2,2,2,452,50.7,6.81,6.43,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","CASP2","ENSG00000106144; ENSPPAG00000028627; ENSPTRG00000019805; ENSPTRG00000047033","Apoptosis modulation and signaling; Parkinson's disease pathway; Apoptosis; Apoptosis modulation by HSP70; Acute viral myocarditis; Apoptosis modulation by HSP70","TP53 Regulates Transcription of Caspase Activators and Caspases; NOD1/2 Signaling Pathway; NADE modulates death signalling","Apoptosis",79.2,79,82.3,102.3,105.8,102.7,0.7738095238095238,-0.3699496097503057,1.081205305284303E-4,3.966091831961432,8.793803149645665E-3,2.0558232603423647,96]
["High","P42695","condensin-2 complex subunit D3 [OS=Homo sapiens]",14,15,27,15,1498,168.8,7.5,41.1,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","other molecular function","NCAPD3","ENSG00000151503","","Condensation of Prophase Chromosomes","",1096.7,1120.8,1085.3,1131.8,1106.4,1126.5,0.98160311469076,-0.02678826811374061,0.18802484792838695,0.7257847539006571,0.3600044170242387,0.44369217068414285,4078]
["High","P42858","huntingtin [OS=Homo sapiens]",13,33,62,33,3142,347.4,6.2,114.75,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","HTT","ENSG00000197386","Mesodermal commitment pathway; Mesodermal commitment pathway; ERK pathway in Huntington's disease; Rett syndrome causing genes","Regulation of MECP2 expression and activity","Huntington disease; Pathways of neurodegeneration",2298.6,2443.2,2377.9,2503.4,2535.7,2555.3,0.9374934162014115,-0.09311953606820295,0.02360958540751685,1.6269116392155796,0.09722765973728459,1.0122101675589916,1896]
["High","P43155","Carnitine O-acetyltransferase [OS=Homo sapiens]",8,4,5,4,626,70.8,8.44,10.23,"other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","CRAT","ENSG00000095321","Fatty acid beta-oxidation","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","",222.3,230.1,234.6,227.3,234.4,238.1,0.9817090597313518,-0.026632565534386997,0.42346707520275445,0.37318035065470734,0.6045768738678198,0.21854846937071076,5469]
["High","P43304","Glycerol-3-phosphate dehydrogenase, mitochondrial [OS=Homo sapiens]",44,25,80,25,727,80.8,7.69,158.64,"other metabolic processes","other membranes;mitochondrion;other cell component","other molecular function","GPD2","ENSG00000115159","Fatty acid beta-oxidation","Triglyceride catabolism; Synthesis of PA","Glycerophospholipid metabolism",3236,3304.9,3259.6,3310.2,3733,3494.6,0.9300328341779119,-0.10464644439845919,0.11862182821617712,0.9258353868439173,0.2686971960289849,0.5707368655932294,3447]
["High","P45880","Voltage-dependent anion-selective channel protein 2 [OS=Homo sapiens]",68,16,150,15,294,31.5,7.56,373.23,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","VDAC2","ENSG00000165637","Alzheimer's disease and miRNA effects; Ferroptosis; Alzheimer's disease","Ub-specific processing proteases; Mitochondrial calcium ion transport","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy",6653,7243.8,6784.7,5318.8,6225.2,5881.1,1.1868798457397662,0.24717389055736075,0.027246660550782332,1.5646867188273927,0.10568401668182238,0.9759906890574118,2013]
["High","P45984-1","Mitogen-activated protein kinase 9 [OS=Homo sapiens]",10,5,14,4,424,48.1,5.63,22.71,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","MAPK9","ENSG00000050748; ENSGGOG00000016519; ENSOCUG00000015542; ENSPPAG00000038007; ENSPTRG00000017633","IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Wnt signaling pathway and pluripotency; Splicing factor NOVA regulated synaptic proteins; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; CCL18 signaling pathway; Familial partial lipodystrophy (FPLD); Alzheimer's disease; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway; MAPK signaling pathway; Wnt signaling pathway","Oxidative Stress Induced Senescence; FCERI mediated MAPK activation; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors","Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; cAMP signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Mitophagy; Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Apoptosis; Necroptosis; Wnt signaling pathway; Osteoclast differentiation; Focal adhesion; Tight junction; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; Insulin signaling pathway; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Adipocytokine signaling pathway; Relaxin signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Measles; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Choline metabolism in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",425.5,364.5,406.9,360.7,346.6,333.8,1.1496494092786478,0.20119397194396738,0.05741382197929522,1.2409835416314419,0.16652567682553382,0.7785187925247458,2692]
["High","P46087-2","Isoform 2 of Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase [OS=Homo sapiens]",44,30,141,30,808,88.9,9.23,295.98,"","","","NOP2","","","","",5539.5,5416.6,5532.6,5515.3,5272.3,5603.1,1.0059790002867481,0.008600189339880136,0.7746897586994703,0.11087218531339318,0.8688275834423246,0.0610663996030274,6962]
["High","P46736","Lys-63-specific deubiquitinase BRCC36 [OS=Homo sapiens]",27,8,23,8,316,36,5.92,53.29,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","BRCC3","ENSG00000185515","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","Homologous recombination; NOD-like receptor signaling pathway",887.1,805.8,866.7,743,742.3,745.2,1.1475453934095496,0.19855122340079073,0.01091233295882121,1.9620823912238254,0.06396658839525225,1.1940468113994722,1332]
["High","P46777","60S ribosomal protein L5 [OS=Homo sapiens]",64,20,329,20,297,34.3,9.72,573.24,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL5","ENSG00000122406","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",15031.3,15890.7,15503.2,15888.1,16224.6,16035.1,0.9642226643792654,-0.052561753720631765,0.09782446304411578,1.0095525272516375,0.23669457931467494,0.625811687996907,3227]
["High","P46934-4","Isoform 4 of E3 ubiquitin-protein ligase NEDD4 [OS=Homo sapiens]",6,5,7,3,900,104.2,5.97,7.19,"","","","NEDD4","","","","",14.1,16.1,11.7,16.3,8.2,11.8,1.1542699724517909,0.20698069570360117,0.5224079658639325,0.2819902094045498,0.6864627057330166,0.16338305221355964,5942]
["High","P47895","Aldehyde dehydrogenase family 1 member A3 [OS=Homo sapiens]",20,11,19,8,512,56.1,7.25,35.56,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","ALDH1A3","ENSG00000184254","Ethanol effects on histone modifications; Vitamin A and carotenoid metabolism","RA biosynthesis pathway","Retinol metabolism; Metabolic pathways",649.2,606.5,593.8,608.3,593,576.1,1.0405648700348824,0.05736690717837374,0.2780866216870485,0.5558199038623699,0.46286513368844057,0.33454553215089294,4691]
["High","P47897","glutamine--tRNA ligase [OS=Homo sapiens]",51,38,153,37,775,87.7,7.15,333.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;mitochondrion;other cell component","enzyme regulator activity;other molecular function","QARS1","ENSG00000172053","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis; Metabolic pathways",6683.2,6943.6,6609.8,5576.2,5933.5,5954,1.1587807852860503,0.2126076673854704,0.004364952762248244,2.360020451891042,0.039908139540555373,1.3989385179214118,854]
["High","P48200","iron-responsive element-binding protein 2 [OS=Homo sapiens]",4,4,4,4,963,105,7.05,6.34,"","","","","","","","",149.3,154.2,152.4,130.6,118.2,135.5,1.186312776476711,0.2464844328019624,0.011103418050989172,1.9545433084046409,0.06464987930061405,1.1894322815976044,1341]
["High","P48444","Coatomer subunit delta [OS=Homo sapiens]",49,22,104,22,511,57.2,6.21,174.94,"transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","","ARCN1","ENSG00000095139","miR-517 relationship with ARCN1 and USP1","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",4820.6,4920.6,4861.2,4587.6,5061.1,4815.7,1.009540665357706,0.01369902511047981,0.7585780229412009,0.11999974356523789,0.8586513776638006,0.06618312893797441,6898]
["High","P48553","Trafficking protein particle complex subunit 10 [OS=Homo sapiens]",3,3,4,3,1259,142.1,6.04,10.65,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC10","ENSG00000160218","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",109.7,111.4,124.8,111,125,114,0.9882857142857143,-0.016999908346763057,0.8412605983818695,0.07506945139825588,0.9091436335177352,0.04136749816820597,7225]
["High","P48681","Nestin [OS=Homo sapiens]",55,73,259,73,1621,177.3,4.36,559.8,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;other molecular function","NES","ENSG00000132688","","","",10632,10275.1,10724.6,12483.3,9682.2,10028.2,0.9825431683838763,-0.025407300803445835,0.8439700702534136,0.07367295450499015,0.9105593904295501,0.04069172247240823,7237]
["High","P49023","Paxillin [OS=Homo sapiens]",32,12,31,12,591,64.5,6.19,52.07,"cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PXN","ENSG00000089159","Integrin-mediated cell adhesion; Prolactin signaling pathway; Oncostatin M signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; 3q29 copy number variation syndrome; Regulation of actin cytoskeleton","VEGFA-VEGFR2 Pathway; GAB1 signalosome; Smooth Muscle Contraction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","Chemokine signaling pathway; VEGF signaling pathway; Focal adhesion; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Human papillomavirus infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis; Proteoglycans in cancer",1088.3,1017.7,1064.5,1176.3,1054.9,1102.7,0.9509883319835628,-0.07250045463508614,0.254241094349981,0.5947542507647041,0.4371535927515198,0.3593659480070353,4541]
["High","P49069","calcium signal-modulating cyclophilin ligand [OS=Homo sapiens]",22,5,9,5,296,32.9,8.05,27.55,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","CAMLG","ENSG00000164615","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",425.3,325.8,324.8,303.7,297.4,302,1.1913409367733365,0.2525863413332736,0.15957821661451999,0.7970263927458331,0.3240537621134388,0.48938293222464746,3845]
["High","P49327","Fatty acid synthase [OS=Homo sapiens]",60,115,750,114,2511,273.3,6.44,1825.21,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","FASN","ENSG00000169710","AMP-activated protein kinase (AMPK) signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway","ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism","Fatty acid biosynthesis; Metabolic pathways; Fatty acid metabolism; AMPK signaling pathway; Insulin signaling pathway; Alcoholic liver disease",30350.6,31563,30317.1,28370.4,30789.1,29945.9,1.0350741930343166,0.04973418230083461,0.2721737455857525,0.5651537700112748,0.4558413997283474,0.3411862345371972,4662]
["High","P49406","39S ribosomal protein L19, mitochondrial [OS=Homo sapiens]",35,10,18,9,292,33.5,9.5,36.57,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPL19","ENSG00000115364","Cytoplasmic ribosomal proteins","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",891.9,920.1,901.6,861.4,1063.3,958.5,0.9411764705882353,-0.08746284125033943,0.39136565922616,0.40741728461283166,0.5749356664605564,0.24038074881351185,5315]
["High","P49441","Inositol polyphosphate 1-phosphatase [OS=Homo sapiens]",14,3,4,3,399,44,5.26,7.09,"other metabolic processes;signal transduction","cytosol","other molecular function","INPP1","ENSG00000151689","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",30.1,34.9,30.4,31.9,36.1,34.2,0.933463796477495,-0.09933402493210997,0.31419707679910674,0.502797859830492,0.5015847016249081,0.2996557179931389,4891]
["High","P49591","Serine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",47,24,116,24,514,58.7,6.43,211.34,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SARS1","ENSG00000031698","VEGFA-VEGFR2 signaling pathway","Cytosolic tRNA aminoacylation; Selenocysteine synthesis","Aminoacyl-tRNA biosynthesis",4053.1,4013.1,4042.3,4079.7,4143.2,4083.8,0.983894951530467,-0.023423804725548964,0.04968447559555846,1.3037792896650944,0.15255068244204503,0.8165858451821678,2543]
["High","P49736","DNA replication licensing factor mcm2 [OS=Homo sapiens]",58,46,213,46,904,101.8,5.52,476.82,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM2","ENSG00000073111","Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","DNA replication; Cell cycle",7684.5,8010,7599.6,7822.6,8441.5,8269.4,0.949481321458414,-0.074788475454533,0.13736573861284335,0.8621215743131224,0.29481904537907666,0.5304444643819517,3638]
["High","P49756-1","RNA-binding protein 25 [OS=Homo sapiens]",39,36,103,36,843,100.1,6.32,213.46,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RBM25","ENSG00000119707; ENSGGOG00000002415; ENSPPAG00000039402; ENSPTRG00000006509","","","Spliceosome",5067.9,4933.6,5120.8,5236.7,5087.4,5218.9,0.9729331531879304,-0.03958740897368638,0.1269138186561854,0.89649108839075,0.2805614654777734,0.5519719786376456,3532]
["High","P49773","Histidine triad nucleotide-binding protein 1 [OS=Homo sapiens]",40,5,14,5,126,13.8,6.95,36.19,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","HINT1","ENSG00000169567","","","",962.9,919.5,1045.5,1045.1,977,953.3,0.9840357598978291,-0.023217350776255016,0.7484074776482819,0.12586188193477113,0.8522044021405549,0.06945622674151053,6857]
["High","P49840","Glycogen synthase kinase-3 alpha [OS=Homo sapiens]",30,8,17,6,483,50.9,8.75,34.2,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","GSK3A","ENSG00000105723","IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation","XBP1(S) activates chaperone genes; Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein","Chemokine signaling pathway; Dopaminergic synapse; Non-alcoholic fatty liver disease; Shigellosis",284.5,309.2,292.1,281.8,313.8,288.2,1.0022629554197784,3.261066128311123E-3,0.9590530109134173,0.018157386874284413,0.9778383271365843,0.00973294422731783,7658]
["High","P49915","GMP synthase [glutamine-hydrolyzing] [OS=Homo sapiens]",73,43,195,43,693,76.7,6.87,428.98,"other metabolic processes","cytosol","other molecular function","GMPS","ENSG00000163655","","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Drug metabolism; Metabolic pathways",7565,8156.4,7978.5,8352.5,9077.2,8701.7,0.9069510244380324,-0.14090344789109788,0.041145162093081264,1.3856812224152035,0.13659074218655548,0.864578735160669,2352]
["High","P50148","Guanine nucleotide-binding protein G(Q) subunit alpha [OS=Homo sapiens]",12,5,10,4,359,42.1,5.68,22.41,"cell-cell signaling;stress response;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","GNAQ","ENSG00000156052","Thyroid stimulating hormone (TSH) signaling pathway; Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Circadian rhythm genes; Cell-type dependent selectivity of CCK2R signaling; Hippo signaling regulation pathways; Gastrin signaling pathway; PKC-gamma calcium signaling pathway in ataxia; GPR143 in melanocytes and retinal pigment epithelium cells; Airway smooth muscle cell contraction; Prostaglandin and leukotriene metabolism in senescence ; Alzheimer's disease; Calcium regulation in cardiac cells; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 2 and STAT3 signaling","G alpha (q) signalling events; Thrombin signalling through proteinase activated receptors (PARs); G-protein activation; ADP signalling through P2Y purinoceptor 1; Thromboxane signalling through TP receptor; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Apelin signaling pathway; Gap junction; Platelet activation; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Yersinia infection; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",307.2,304.8,328.2,277.3,326,283.7,1.0599774520856822,0.08403357600531036,0.3555414664370122,0.44910974065974835,0.5408275413871403,0.2669412002618757,5133]
["High","P50395-1","Rab GDP dissociation inhibitor beta [OS=Homo sapiens]",74,32,218,24,445,50.6,6.47,449.1,"transport;signal transduction","non-structural extracellular;other membranes;cytosol;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","GDI2","ENSG00000057608; ENSNLEG00000035201","","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs","",8928.2,9790.8,9462.2,9106.4,10169.9,9595.9,0.9760669432880072,-0.034947996855717776,0.5929266409307035,0.22699903582594883,0.7396662745465622,0.1309641827206096,6259]
["High","P50479-1","PDZ and LIM domain protein 4 [OS=Homo sapiens]",3,1,1,1,330,35.4,7.91,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","PDLIM4","ENSG00000131435; ENSPTRG00000017214","","","",129.8,123.3,138.2,101.4,102.6,110.7,1.2434064188115668,0.3142979316023707,0.00803241474905784,2.095153875077438,0.05392699429118109,1.268193785147251,1163]
["High","P50552","Vasodilator-stimulated phosphoprotein [OS=Homo sapiens]",57,16,65,16,380,39.8,8.94,143.39,"cell organization and biogenesis;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","VASP","ENSG00000125753","Integrin-mediated cell adhesion; Focal adhesion","Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions","Rap1 signaling pathway; cGMP-PKG signaling pathway; Focal adhesion; Tight junction; Platelet activation; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration",2013,1907.1,1971.8,2182.5,2102.9,2065.9,0.9276683513611386,-0.10831897203925381,0.029503016795798153,1.530133573486903,0.11074978612576537,0.9556571037910292,2080]
["High","P50851-1","Lipopolysaccharide-responsive and beige-like anchor protein [OS=Homo sapiens]",19,35,60,1,2863,318.9,5.6,118.25,"other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","LRBA","ENSG00000198589","","","",2319.6,2254.1,2202.9,2142.3,2141.1,2116.9,1.0587941190256709,0.08242208665159402,0.022609245736178646,1.6457139258492226,0.09480826568640327,1.0231537978359109,1862]
["High","P50991","T-complex protein 1 subunit delta [OS=Homo sapiens]",71,31,355,31,539,57.9,7.83,816.82,"transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CCT4","ENSG00000115484","16p11.2 proximal deletion syndrome","Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; Folding of actin by CCT/TriC","",12814,13212.8,12774.1,12586.8,13789.3,13242.7,0.9793557603965792,-0.03009506700280683,0.5072279161232026,0.2947968523569433,0.6750358904192886,0.17067313591463953,5867]
["High","P51148","Ras-related protein Rab-5C [OS=Homo sapiens]",74,11,46,9,216,23.5,8.41,119.88,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","RAB5C","ENSG00000108774","Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells","Clathrin-mediated endocytosis; Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Golgi Associated Vesicle Biogenesis; TBC/RABGAPs","Ras signaling pathway; Endocytosis; Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection; Amoebiasis; Tuberculosis",1358.6,1489.5,1407,1207,1423,1317.7,1.0778681257441043,0.10818067904303509,0.23381714771100118,0.6311236416635791,0.414260106495915,0.38272688751486267,4407]
["High","P51511","Matrix metalloproteinase-15 [OS=Homo sapiens]",7,3,4,3,669,75.8,7.46,11.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes","enzyme regulator activity;other molecular function","MMP15","ENSG00000102996","Matrix metalloproteinases; Epithelial to mesenchymal transition in colorectal cancer","Collagen degradation; Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action",190.4,151.6,151.6,216.2,221.6,220.2,0.7501519756838906,-0.414745189473186,0.013648070948505368,1.864928728522369,0.0712327125440708,1.147320517392176,1496]
["Medium","P51512-1","Matrix metalloproteinase-16 [OS=Homo sapiens]",1,1,1,1,607,69.5,8.54,2,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","MMP16","ENSCANG00000029811; ENSCATG00000039014; ENSCSAG00000012941; ENSG00000156103; ENSGGOG00000027756; ENSMFAG00000040046; ENSMMUG00000013193; ENSMNEG00000003965; ENSPANG00000010068; ENSRBIG00000031261; ENSRROG00000034264","Matrix metalloproteinases","Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action; MicroRNAs in cancer",85.1,77.1,72.1,80,68,78.3,1.0353513035793194,0.05012036959624291,0.643008526899419,0.19178326788322514,0.7764631268219399,0.10987916350012705,6466]
["High","P51648","Fatty aldehyde dehydrogenase [OS=Homo sapiens]",24,11,36,11,485,54.8,7.88,85.84,"other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ALDH3A2","ENSG00000072210","Fragile X syndrome; Tryptophan metabolism; Fluoroacetic acid toxicity","RND2 GTPase cycle; RND1 GTPase cycle","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease",1589.6,1619.3,1555.9,1524.5,1652.8,1604,0.9965490556961495,-0.004987270588079205,0.9012791707982304,0.04514066567147806,0.9443354489523058,0.02487370723704767,7452]
["High","P51688","N-sulphoglucosamine sulphohydrolase [OS=Homo sapiens]",12,4,8,4,502,56.7,6.95,19.39,"protein metabolism;other metabolic processes","other cytoplasmic organelle","other molecular function","SGSH","ENSG00000181523","Glycosaminoglycan degradation","HS-GAG degradation; MPS IIIA - Sanfilippo syndrome A","Glycosaminoglycan degradation; Metabolic pathways; Lysosome",169.4,180.6,192.6,157.6,160,161.1,1.133486526007938,0.18076724156209967,0.034760545609394254,1.4589134153853522,0.12275456359934434,0.9109623533054307,2211]
["High","P51797-1","Chloride transport protein 6 [OS=Homo sapiens]",4,2,2,2,869,97.2,6.81,5.36,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","CLCN6","ENSG00000011021","","Signaling by BRAF and RAF1 fusions; Stimuli-sensing channels","",20.4,25,29.7,31.1,30.3,24.9,0.870220162224797,-0.20054765166468355,0.32326312444449273,0.4904438337851938,0.5104223408822244,0.29207032505975655,4945]
["Medium","P51825","AF4/FMR2 family member 1 [OS=Homo sapiens]",1,1,1,1,1210,131.3,9.2,2.1,"other biological processes","nucleus","","AFF1","ENSG00000172493","","","Transcriptional misregulation in cancer",66.1,60.1,66.1,66.1,77.4,89.2,0.826385904598195,-0.2751124480654515,0.12520775005094126,0.9023687885362232,0.2781286237262445,0.5557543132334306,3515]
["High","P51948-1","CDK-activating kinase assembly factor MAT1 [OS=Homo sapiens]",28,6,12,6,309,35.8,6.09,32.73,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","enzyme regulator activity;kinase activity;other molecular function","MNAT1","ENSCANG00000033478; ENSCATG00000030975; ENSCSAG00000014164; ENSG00000020426; ENSMFAG00000000901; ENSMMUG00000001642; ENSNLEG00000013781; ENSPPAG00000033622; ENSPTRG00000006412; ENSRROG00000035712","Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; Eukaryotic transcription initiation; G1 to S cell cycle control","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin D associated events in G1; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Basal transcription factors; Nucleotide excision repair",433,444.5,448.5,419.6,413.7,413.9,1.063181526619628,0.08838794230216551,0.006429346197323283,2.1918331884025886,0.048975936691414826,1.3100172491357265,1025]
["High","P51991-1","Heterogeneous nuclear ribonucleoprotein A3 [OS=Homo sapiens]",52,24,241,22,378,39.6,9.01,505.27,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","transporter activity;nucleic acid binding activity","HNRNPA3; HNRPA3","ENSG00000170144; ENSGGOG00000006130; ENSHGLG00000005451; ENSPPAG00000023768; ENSPTRG00000012676; ENSSTOG00000025125","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Spliceosome; Amyotrophic lateral sclerosis",10091,10014.5,10239.3,11188.2,11300.1,11533.5,0.8919222380943982,-0.16501016008473976,5.3890637792349363E-4,3.268486676525354,0.01669754364613745,1.7773474126482631,252]
["High","P52306-1","Rap1 GTPase-GDP dissociation stimulator 1 [OS=Homo sapiens]",27,11,23,11,607,66.3,5.31,47.1,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;ER/Golgi","enzyme regulator activity","RAP1GDS1","ENSG00000138698","","RHOT2 GTPase cycle; RHOT1 GTPase cycle","",1020.8,1032.3,1031.5,1022.7,990.1,1008.9,1.0208160968990965,0.029722983758329567,0.1077299866983169,0.9676633937776555,0.25244769992210636,0.5978285818537702,3332]
["High","P52597","Heterogeneous nuclear ribonucleoprotein F [OS=Homo sapiens]",66,18,246,16,415,45.6,5.58,405.27,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPF","ENSG00000169813","MECP2 and associated Rett syndrome","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",5571.7,5581,5699.5,5880.9,5800.1,5808.3,0.9635720126019911,-0.05353560445200986,0.011881130197142027,1.9251422449578632,0.06645262505679438,1.1774878585863702,1396]
["High","P52739","Zinc finger protein 131 [OS=Homo sapiens]",23,9,13,9,623,71.4,5.19,20.41,"other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","ZNF131","ENSG00000172262","","SUMOylation of transcription cofactors","",266.7,301.2,271.2,258,288.5,255.2,1.0466508669078207,0.06578028030105278,0.4581148311169879,0.3390256480449057,0.6355651388346556,0.19683993214897838,5628]
["High","P52789","Hexokinase-2 [OS=Homo sapiens]",46,37,122,34,917,102.3,6.05,291.02,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component","kinase activity;other molecular function","HK2","ENSG00000159399","Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis","Glycolysis","Glycolysis / Gluconeogenesis; Fructose and mannose metabolism; Galactose metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Neomycin, kanamycin and gentamicin biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of nucleotide sugars; HIF-1 signaling pathway; Insulin signaling pathway; Type II diabetes mellitus; Carbohydrate digestion and absorption; Shigellosis; Central carbon metabolism in cancer",4434.7,4319.7,4538.9,4419.6,4448.5,4637.6,{"$f":"AVERAGE(T2242:V2242)/AVERAGE(W2242:Y2242)","v":0.9842733068260066},{"$f":"LOG(Z2242,2)","v":-0.022869125202621604},{"$f":"TTEST(T2242:V2242,W2242:Y2242,2,2)","v":0.4896337504120364},{"$f":"-LOG10(AB2242)","v":0.3101286539496611},{"$f":"AB2242*7808/AF2242","v":0.6620017875700744},{"$f":"-LOG10(AD2242)","v":0.17914083785520762},5775]
["High","P52907","F-actin-capping protein subunit alpha-1 [OS=Homo sapiens]",67,13,143,11,286,32.9,5.69,385.37,"cell organization and biogenesis","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity","CAPZA1","ENSG00000116489","","MHC class II antigen presentation; Advanced glycosylation endproduct receptor signaling; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production","Endocytosis",4949.3,4850.9,4812,4934.7,4950,5110.2,0.9744779891829889,-0.03729849560755641,0.13998816291691765,0.8539086857303673,0.2978276773992624,0.5260349453238212,3670]
["High","P53367","Arfaptin-1 [OS=Homo sapiens]",54,16,45,1,373,41.7,6.7,91.35,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","ARFIP1","ENSG00000164144","","","",1633.2,1590.9,1535.4,1469.7,1349.3,1384.4,1.1322976637959747,0.17925327056466728,0.01529187704161105,1.8155392026988186,0.07600189429719865,1.1191755830801566,1571]
["High","P53611","Geranylgeranyl transferase type-2 subunit beta [OS=Homo sapiens]",20,7,20,7,331,36.9,5.03,29.64,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RABGGTB","ENSG00000137955","","RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain","",539.3,644.8,560.2,506.2,584.6,537.4,1.0713057363960203,0.09937026480951715,0.3825893680843326,0.4172671029089919,0.5665195877114487,0.24678506958182056,5273]
["High","P53667-1","LIM domain kinase 1 [OS=Homo sapiens]",8,3,6,3,647,72.5,6.98,12.9,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","LIMK1","ENSG00000106683; ENSPTRG00000019286; ENSPTRG00000045946","Microtubule cytoskeleton regulation; VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; G13 signaling pathway","Regulation of actin dynamics for phagocytic cup formation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Axon guidance; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Human immunodeficiency virus 1 infection",201.1,187.7,202.7,197.9,209.7,212.2,0.9543401097128106,-0.06742458635906493,0.21948242215576913,0.6586002556789818,0.39835396378248383,0.3997308570717901,4302]
["High","P53778","Mitogen-activated protein kinase 12 [OS=Homo sapiens]",10,3,3,3,367,41.9,6.39,4.87,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","MAPK12","ENSG00000188130","Integrin-mediated cell adhesion; Parkinson's disease pathway; S1P receptor signal transduction; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway","p38MAPK events; Negative regulation of MAPK pathway; VEGFA-VEGFR2 Pathway; Myogenesis; NOD1/2 Signaling Pathway; DSCAM interactions; Activation of PPARGC1A (PGC-1alpha) by phosphorylation","Endocrine resistance; MAPK signaling pathway; Rap1 signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; VEGF signaling pathway; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Leukocyte transendothelial migration; Thermogenesis; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Relaxin signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Proteoglycans in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",72.4,48.3,58.3,65.3,61.3,65.2,0.9332638164754952,-0.09964313286651227,0.5809642159421793,0.23585061683076117,0.7292875559608579,0.13710119686294442,6220]
["High","P53985","Monocarboxylate transporter 1 [OS=Homo sapiens]",15,13,93,13,500,53.9,8.66,223.41,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;other molecular function","SLC16A1","ENSG00000155380; ENSG00000281917","Photodynamic therapy-induced HIF-1 survival signaling; Fragile X syndrome","Basigin interactions; Pyruvate metabolism; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)","",6081.5,6218,6159.3,6582.2,6018.1,6510.3,0.9658932738898831,-0.05006430720944063,0.2976596656993976,0.5262800103346169,0.48479905502313236,0.3144382353736166,4794]
["High","P54252","Ataxin-3 [OS=Homo sapiens]",12,3,5,3,364,41.8,4.91,7.43,"","","","","","","","",137.8,142.6,126.2,162.5,166.1,150.9,0.8479666319082377,-0.23792060006076077,0.02209344098768126,1.655736638787601,0.09390614438313297,1.0273059904347739,1837]
["High","P54578","Ubiquitin carboxyl-terminal hydrolase 14 [OS=Homo sapiens]",51,21,101,21,494,56,5.3,239.24,"protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","USP14","ENSG00000101557","","Ub-specific processing proteases","",4016,3764.8,3970.2,3930.9,3761.5,3838.1,1.0191231950045532,0.027328459824855985,0.46664495775403875,0.331013422499128,0.64305750620253,0.19175018802491095,5666]
["High","P54687","Branched-chain-amino-acid aminotransferase, cytosolic [OS=Homo sapiens]",47,16,148,2,386,42.9,5.3,289.85,"cell cycle OR cell proliferation;other metabolic processes","cytosol;mitochondrion","other molecular function","BCAT1","ENSG00000060982","Amino acid metabolism; One-carbon metabolism and related pathways","Branched-chain amino acid catabolism","Cysteine and methionine metabolism; Valine, leucine and isoleucine degradation; Valine, leucine and isoleucine biosynthesis; Pantothenate and CoA biosynthesis; Metabolic pathways; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors",5590.6,5630.2,5720.8,6000.2,5954,6058.4,0.9405416208653942,-0.0884363075583508,1.8806186838864725E-3,2.72569925350427,0.028457113728266623,1.545809150472846,516]
["High","P54764","Ephrin type-A receptor 4 [OS=Homo sapiens]",5,3,3,3,986,109.8,6.61,10.23,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","EPHA4","ENSG00000116106","Spinal cord injury; Gene regulatory network modelling somitogenesis ; Fragile X syndrome; Somitogenesis in the context of spondylocostal dysostosis","EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse","Axon guidance",112.4,109.1,96,106.2,126.4,119.7,0.9012205506670451,-0.15004788294807322,0.2097347275111517,0.678329653856203,0.38714154903240483,0.41213021657261,4230]
["High","P54920","alpha-soluble nsf attachment protein [OS=Homo sapiens]",59,15,77,15,295,33.2,5.36,211.67,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","NAPA","ENSG00000105402","Synaptic vesicle pathway; VEGFA-VEGFR2 signaling pathway","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network; COPI-dependent Golgi-to-ER retrograde traffic; Intra-Golgi traffic","Synaptic vesicle cycle",2722.8,2688.9,2698.6,2551.9,2687,2673.1,1.025063195146613,0.03571285462263633,0.20805230633033361,0.6818274655428165,0.3848548703689279,0.4147030130385893,4221]
["High","P55061","Bax inhibitor 1 [OS=Homo sapiens]",3,1,2,1,237,26.5,8.54,4.76,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","TMBIM6","ENSG00000139644","","","Pathogenic Escherichia coli infection",176.5,192.1,189,98.8,115.5,100.9,1.7690355329949237,0.8229630264120468,3.3878151870023936E-4,3.4700802894435374,0.013995799460378143,1.854002288958146,189]
["High","P55145","Mesencephalic astrocyte-derived neurotrophic factor [OS=Homo sapiens]",19,4,7,4,182,20.7,8.69,13.77,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","MANF","ENSG00000145050","Orexin receptor pathway","Platelet degranulation","",330.6,307.4,341,353.3,278.9,272.8,1.0817679558011049,0.11339106763312715,0.42378276433911,0.37285671044880314,0.6049169696452963,0.2183042321235985,5470]
["High","P55265-1","Double-stranded RNA-specific adenosine deaminase [OS=Homo sapiens]",49,54,263,54,1226,136,8.65,499.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ADAR","ENSG00000160710","Measles virus infection; Cytosolic DNA-sensing pathway","Interferon alpha/beta signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins","Cytosolic DNA-sensing pathway; Measles; Influenza A; Coronavirus disease",13454.4,13829.8,13509.9,13820.6,14198.2,14318.5,0.9635498720985985,-0.05356875439929884,0.053856788648904495,1.2687595460904921,0.15976968304355862,0.7965056263737745,2632]
["High","P55786","puromycin-sensitive aminopeptidase [OS=Homo sapiens]",50,37,153,37,919,103.2,5.72,323.71,"protein metabolism;other metabolic processes;stress response","cytosol;nucleus;other cell component","other molecular function","NPEPPS","ENSG00000141279","","Antigen processing: Ubiquitination & Proteasome degradation","",6497.8,6673.6,6464.2,6799.8,7042.9,6932.3,0.9451552346570398,-0.08137679425491157,0.016543402418376905,1.7813751659101755,0.07968592602263225,1.0986183761000552,1621]
["High","P55854","Small ubiquitin-related modifier 3 [OS=Homo sapiens]",20,2,6,1,103,11.6,5.49,17.4,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SUMO3","ENSG00000184900","Exercise-induced circadian regulation","SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; SUMOylation of immune response proteins; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed","Nucleocytoplasmic transport; Fluid shear stress and atherosclerosis",665.8,609.9,581.9,415.1,349.9,413.1,1.576776165011459,0.6569778734780132,2.2693376616929575E-3,2.644100879302543,0.029880250358345045,1.5246157680081702,593]
["High","P56270-2","Isoform 2 of Myc-associated zinc finger protein [OS=Homo sapiens]",14,7,19,5,493,51,9.1,47.84,"","","","MAZ","","","","",589,594,651.2,764.4,772.1,862.9,0.7644411102775693,-0.3875227289231595,7.292238881979044E-3,2.137139112997582,0.05171462415121923,1.286386627310698,1101]
["High","P56747","Claudin-6 [OS=Homo sapiens]",25,5,20,5,220,23.3,8,42.93,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CLDN6","ENSG00000184697","Epithelial to mesenchymal transition in colorectal cancer","Tight junction interactions","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Pathogenic Escherichia coli infection; Hepatitis C",712.5,726.6,701.7,664.2,636.2,692.3,1.0743212726451548,0.10342549159250444,0.04957121759663517,1.3047704135740603,0.15250278447380908,0.8167222266741109,2538]
["High","P57060","RWD domain-containing protein 2B [OS=Homo sapiens]",5,1,1,1,319,36.3,5.87,4.78,"","","","RWDD2B","ENSG00000156253","","","",75.9,66.8,65,53.4,59.8,66.5,{"$f":"AVERAGE(T2370:V2370)/AVERAGE(W2370:Y2370)","v":1.1558152476349473},{"$f":"LOG(Z2370,2)","v":0.20891080733470596},{"$f":"TTEST(T2370:V2370,W2370:Y2370,2,2)","v":0.139335283340594},{"$f":"-LOG10(AB2370)","v":0.8559388949197452},{"$f":"AB2370*7808/AF2370","v":0.2972486044599339},{"$f":"-LOG10(AD2370)","v":0.5268801756555205},3660]
["High","P57081-1","tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 [OS=Homo sapiens]",10,2,2,2,412,45.5,7.11,3.57,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","","WDR4","ENSG00000160193","","tRNA modification in the nucleus and cytosol","",15.3,17.8,15.3,23.2,20.8,22.7,0.7256371814092955,-0.46267971390999024,0.005318801801820128,2.2741861927927087,0.04427420519041744,1.3538492265131377,938]
["High","P57772","selenocysteine-specific elongation factor [OS=Homo sapiens]",9,5,17,5,596,65.3,8.35,38.67,"protein metabolism;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EEFSEC","ENSG00000132394; ENSG00000284869","","Selenocysteine synthesis","",1628.4,1658.4,1629.5,1401.3,1404.4,1386.9,1.1726136526260553,0.22972775910204848,2.75242438961909e-05,4.560284602464194,0.004997890612592059,2.301213253385146,43]
["High","P58107","epiplakin [OS=Homo sapiens]",32,43,92,40,5090,555.3,5.6,194.31,"","","","","","","","",2721.3,2605.3,2571.3,2157.3,2117.2,2129.1,1.2333531138734464,0.3025859081757976,4.4636916211571517E-4,3.350305816726376,0.015219434138862464,1.8176014944076286,229]
["High","P60033","CD81 antigen [OS=Homo sapiens]",18,2,18,2,236,25.8,5.29,45.32,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","CD81","ENSG00000110651","B cell receptor signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; IL-18 signaling pathway; 16p11.2 distal deletion syndrome","Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","B cell receptor signaling pathway; Malaria; Hepatitis C",484.2,529.2,518.3,429.5,414.1,447.5,1.186352722484703,0.2465330110003339,0.008522792718265972,2.069418073848611,0.05596801139127057,1.2520601238086673,1189]
["High","P60660","Myosin light polypeptide 6 [OS=Homo sapiens]",39,6,24,5,151,16.9,4.65,59.47,"developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL6","ENSG00000092841","Ciliary landscape","Smooth Muscle Contraction; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; RHO GTPases activate PKNs","Vascular smooth muscle contraction; Tight junction; Oxytocin signaling pathway",805.8,714.7,829.1,827.5,755.1,729,1.0164388302474476,0.02352339574924848,0.7952832130091414,0.09947818462185966,0.882417411848142,0.05432593099061969,7037]
["High","P60763","Ras-related C3 botulinum toxin substrate 3 [OS=Homo sapiens]",26,5,33,1,192,21.4,8.15,80.24,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","RAC3","ENSG00000169750","Integrin-mediated cell adhesion; RalA downstream regulated genes; Focal adhesion; MAPK signaling pathway; Microglia pathogen phagocytosis pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Regulation of actin cytoskeleton","RAC3 GTPase cycle; PCP/CE pathway","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Wnt signaling pathway; Axon guidance; VEGF signaling pathway; Focal adhesion; Adherens junction; Natural killer cell mediated cytotoxicity; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Regulation of actin cytoskeleton; Yersinia infection; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer; Choline metabolism in cancer; Viral myocarditis; Fluid shear stress and atherosclerosis",51.7,66.3,60.8,60.2,61,77.4,0.9003021148036253,-0.15151888634505623,0.40147114789006993,0.3963456602542282,0.5837405442692116,0.23378014129514835,5370]
["High","P61006","Ras-related protein Rab-8A [OS=Homo sapiens]",31,6,18,3,207,23.7,9.07,30.45,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB8A","ENSG00000167461","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape; Joubert syndrome","Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB geranylgeranylation; Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs; VxPx cargo-targeting to cilium","Autophagy; Endocytosis; AMPK signaling pathway; Tight junction; Pancreatic secretion; Amyotrophic lateral sclerosis; Pathways of neurodegeneration",235.1,214.4,240.1,225.7,213.7,248.2,1.002908667830134,0.004190229611037363,0.9609949496725237,0.017278894678091523,0.9790512222133436,0.00919458608994412,7664]
["High","P61088","ubiquitin-conjugating enzyme E2 N [OS=Homo sapiens]",48,6,56,6,152,17.1,6.57,137.06,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2N","ENSG00000177889","IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway; 3q29 copy number variation syndrome","ISG15 antiviral mechanism; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Nonhomologous End-Joining (NHEJ); Aggrephagy; E3 ubiquitin ligases ubiquitinate target proteins; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; Formation of Incision Complex in GG-NER; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Ubiquitin mediated proteolysis; Shigellosis",3236.8,3223.5,3307.3,3086.5,3127,2980.8,1.062353849667729,0.08726438020328227,0.019678316936730226,1.7060120490118065,0.08764877275641164,1.057254160446966,1753]
["High","P61158","actin-related protein 3 [OS=Homo sapiens]",58,22,178,18,418,47.3,5.88,454.13,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ACTR3","ENSG00000115091","Physico-chemical features and toxicity-associated pathways","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Clathrin-mediated endocytosis","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",7498.5,7841.2,7824.4,8384.7,8381.1,8435.3,0.9191701949518075,-0.12159607702993151,3.8494700989294937E-3,2.4145990494394742,0.03804640826891327,1.4196863360712801,790]
["High","P61289-1","Proteasome activator complex subunit 3 [OS=Homo sapiens]",54,15,134,15,254,29.5,5.95,309.53,"cell cycle OR cell proliferation;protein metabolism;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","HEL-S-283; LOC101359250; LOC103001388; LOC111151323; LOC111166421; Psme3; PSME3","ENSBTAG00000019918; ENSCAFG00000014716; ENSCATG00000043580; ENSCCAG00000025926; ENSCGRG00001014333; ENSCGRG00015000348; ENSECAG00000012620; ENSG00000131467; ENSGGOG00000010707; ENSLAFG00000013446; ENSMLUG00000004084; ENSMMUG00000012685; ENSMNEG00000003232; ENSMPUG00000010027; ENSMUSG00000078652; ENSNVIG00000013505; ENSOARG00000003731; ENSOGAG00000009420; ENSPPAG00000043945; ENSPTRG00000009225; ENSPTRG00000049975; ENSRBIG00000001980; ENSRNOG00000051344; ENSSBOG00000024784; ENSSSCG00000017385; ENSSSCG00005010026; ENSSSCG00015075406; ENSSSCG00025054060; ENSSSCG00030072129; ENSSSCG00035013193; ENSSSCG00040025703; ENSSSCG00045007466; ENSSSCG00050060716; ENSSSCG00055025037; ENSSSCG00060042579; ENSSSCG00065003129; ENSSSCG00070012475; ENSSSUG00005017981; ENSSTOG00000028833; ENSTSYG00000002969; ENSUAMG00000013177; ENSUMAG00000025062","Proteasome degradation; Proteasome degradation; Proteasome degradation; Proteasome degradation","Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Hedgehog ligand biogenesis; Hedgehog 'on' state; Regulation of expression of SLITs and ROBOs; ER-Phagosome pathway; Degradation of beta-catenin by the destruction complex; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Downstream TCR signaling; FCERI mediated NF-kB activation; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; FCERI mediated NF-kB activation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; UCH proteinases; ABC-family proteins mediated transport; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Hedgehog ligand biogenesis; Degradation of beta-catenin by the destruction complex; Downstream TCR signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of RUNX3 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Regulation of RAS by GAPs; Autodegradation of the E3 ubiquitin ligase COP1; Neddylation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Separation of Sister Chromatids; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX3 expression and activity; Regulation of PTEN stability and activity; Antigen processing: Ubiquitination & Proteasome degradation","Proteasome; Antigen processing and presentation; Hepatitis C",3450.5,3416,3389.5,3287.3,3481.8,3373.2,1.0112104749415813,0.016083313315154297,0.5554731098038487,0.25533696020910984,0.7113554274804741,0.14791335057239446,6097]
["High","P61326","Protein mago nashi homolog [OS=Homo sapiens]",42,10,73,10,146,17.2,6.11,194.65,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","","MAGOH","ENSG00000162385","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",4114,4409.4,4296.5,3706.2,4617.5,4110.7,1.0310027021810462,0.04404811390688084,0.6671862793428736,0.17575289352581677,0.7945989123107317,0.09985203376564283,6556]
["High","P61803","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [OS=Homo sapiens]",19,2,9,2,113,12.5,7.08,17.53,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity","DAD1","ENSG00000129562","","Asparagine N-linked glycosylation; Maturation of spike protein","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum",345,365.9,354.4,349.6,386.5,366.2,0.9664338201941394,-0.049257152462968586,0.3714313096670119,0.43012149035796604,0.5554751323271458,0.25533537891004626,5221]
["High","P61966","AP-1 complex subunit sigma-1A [OS=Homo sapiens]",16,2,4,2,158,18.7,5.73,11.33,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","AP1S1","ENSG00000106367","","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","Lysosome; Human immunodeficiency virus 1 infection",95.1,97,93.7,82.2,84.4,99,1.0760542168674698,0.10575076974889165,0.277229773410308,0.557160130000201,0.4615373285261588,0.33579316805664894,4690]
["High","P61978-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein K [OS=Homo sapiens]",65,30,512,1,440,48.5,5.54,787.75,"","","","HNRNPK","","","","",22284.5,21169.1,22033.5,24622.1,23389.7,23848.8,0.9113074480313271,-0.13399023633666746,0.012586875100292475,1.9000820772908746,0.06829626183675028,1.1656030665688444,1439]
["High","P62191","26S proteasome regulatory subunit 4 [OS=Homo sapiens]",64,24,191,22,440,49.2,6.21,407.77,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMC1","ENSG00000100764","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; N-glycan trimming in the ER and Calnexin/Calreticulin cycle","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human papillomavirus infection; Epstein-Barr virus infection; Viral carcinogenesis",6133.2,6148.2,6314.3,6483.3,6297.4,6270.1,0.9761112394230163,-0.03488252556330711,0.16210576320908976,0.7902015447726267,0.3277373897298221,0.4844740095573672,3862]
["High","P62263","40S ribosomal protein S14 [OS=Homo sapiens]",38,7,101,7,151,16.3,10.05,285.12,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","RPS14","ENSG00000164587","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); rRNA modification in the nucleus and cytosol","Ribosome; Coronavirus disease",3628.8,3897.4,3895.5,3388.7,3818.8,3816.2,1.0361040304072135,0.05116886462457218,0.4751015948191896,0.3232135117403163,0.6495523117401912,0.1873858672464526,5711]
["High","P62306","Small nuclear ribonucleoprotein F [OS=Homo sapiens]",15,1,10,1,86,9.7,4.67,8.85,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","SNRPF","ENSG00000139343","mRNA processing","snRNP Assembly; mRNA Splicing - Major Pathway; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","Spliceosome",226,273.7,278,239.8,273.2,236.3,1.037902041905779,0.0536702873126893,0.6666655094439582,0.17609201291949048,0.7942209792094027,0.10005864530721209,6554]
["High","P62316","Small nuclear ribonucleoprotein Sm D2 [OS=Homo sapiens]",56,6,37,6,118,13.5,9.91,74.8,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","SNRPD2","ENSG00000125743","mRNA processing","mRNA Splicing - Major Pathway; snRNP Assembly; mRNA Splicing - Minor Pathway","Spliceosome",1742.6,1586.7,1941.5,1944.8,1532.4,1478,1.0636906683887632,0.08907866205598579,0.5895243634865761,0.22949824195288526,0.7365988526329311,0.13276896196165813,6249]
["High","P62487","DNA-directed RNA polymerase II subunit rpb7 [OS=Homo sapiens]",51,6,18,6,172,19.3,5.54,34.5,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR2G","ENSG00000168002","Pyrimidine metabolism; Eukaryotic transcription initiation","Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; mRNA Splicing - Major Pathway; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Inhibition of DNA recombination at telomere; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","RNA polymerase; Huntington disease",404.8,424.1,436.3,426.7,455.7,441.3,0.9558056961547179,-0.06521072948997188,0.19139467327262166,0.7180701532911424,0.36466803536179354,0.43810230269768324,4098]
["High","P62699","Protein yippee-like 5 [OS=Homo sapiens]",23,2,4,2,121,13.8,7.31,8.83,"cell cycle OR cell proliferation","non-structural extracellular;cytoskeleton;nucleus;other cell component","other molecular function","YPEL5","ENSG00000119801","Ciliary landscape","Neutrophil degranulation","",84.8,105.5,100.8,87.2,81.6,81.5,1.1630043947263284,0.21785654843443394,0.1061710160714918,0.973994026363925,0.24976899472317204,0.6024614741138935,3319]
["High","P62820","Ras-related protein Rab-1A [OS=Homo sapiens]",78,14,103,5,205,22.7,6.21,234.8,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB1A","ENSG00000138069","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization","Autophagy; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Legionellosis",4768,5731,5248.8,4801.1,5890.9,5316.3,0.9837271915193994,-0.023669813886879203,0.8462849074943588,0.07248340419216315,0.912552486910089,0.039742147014093385,7241]
["High","P62851","40S ribosomal protein S25 [OS=Homo sapiens]",37,5,10,5,125,13.7,10.11,15.49,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","other molecular function","RPS25","ENSG00000118181; ENSG00000280831","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",867.5,965.3,984,1333.7,940.5,800.8,0.9160325203252033,-0.1265292781381956,0.6265894967355186,0.2030168892947819,0.7651565202550717,0.11624971657181568,6394]
["High","P62873","Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [OS=Homo sapiens]",52,11,53,6,340,37.4,6,145.37,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","cytoskeletal activity;other molecular function","GNB1","ENSG00000078369","Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells; Estrogen signaling pathway","G alpha (q) signalling events; Thrombin signalling through proteinase activated receptors (PARs); G alpha (i) signalling events; Inactivation, recovery and regulation of the phototransduction cascade; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (12/13) signalling events; Olfactory Signaling Pathway; G alpha (z) signalling events; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Sensory perception of sweet, bitter, and umami (glutamate) taste; Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation; Activation of the phototransduction cascade","Ras signaling pathway; Chemokine signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Olfactory transduction; Phototransduction; Relaxin signaling pathway; Morphine addiction; Alcoholism; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",2163.4,2362.3,2291.4,2189.9,2401.3,2411,0.9735654508583016,-0.03865012317897836,0.5420446109458192,0.26596496901453576,0.7022207271055179,0.15352635582381197,6027]
["High","P62913","60S ribosomal protein L11 [OS=Homo sapiens]",33,6,50,6,178,20.2,9.6,106.77,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL11","ENSG00000142676","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",2561.7,2588.4,2771.7,2436.9,2728,2464.3,1.0383526451004037,0.05429649469328546,0.44002457775803006,0.3565230651352114,0.6202765667331105,0.2074146256232596,5539]
["High","P62979","Ubiquitin-40S ribosomal protein S27a [OS=Homo sapiens]",63,11,613,11,156,18,9.64,1106.78,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle","other molecular function","RPS27A","ENSG00000143947","Cytoplasmic ribosomal proteins","Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Glycogen synthesis; Cargo recognition for clathrin-mediated endocytosis; InlA-mediated entry of Listeria monocytogenes into host cells; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Stimuli-sensing channels; Negative regulation of MAPK pathway; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oncogene Induced Senescence; ISG15 antiviral mechanism; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Orc1 removal from chromatin; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Regulation of PLK1 Activity at G2/M Transition; Peroxisomal protein import; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of PTEN stability and activity; Downregulation of ERBB4 signaling; Regulation of PTEN localization; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Oxidative Stress Induced Senescence; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Regulation of TP53 Degradation; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; ER Quality Control Compartment (ERQC); Deactivation of the beta-catenin transactivating complex; Circadian Clock; Regulation of signaling by CBL; Metalloprotease DUBs; Regulation of necroptotic cell death; Cyclin D associated events in G1; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Inactivation of CSF3 (G-CSF) signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Regulation of BACH1 activity; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Negative regulators of DDX58/IFIH1 signaling; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Formation of TC-NER Pre-Incision Complex; Modulation by Mtb of host immune system; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Formation of Incision Complex in GG-NER; Iron uptake and transport; Myoclonic epilepsy of Lafora; DNA Damage Recognition in GG-NER; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Ribosome; Ubiquitin mediated proteolysis; Mitophagy; Parkinson disease; Pathways of neurodegeneration; Shigellosis; Kaposi sarcoma-associated herpesvirus infection; Coronavirus disease",19599.1,18646.3,19780.3,19506.8,17752.8,18028.3,1.0495189725057381,0.06972824694692088,0.23197721603208785,0.6345546678567188,0.41221622730508467,0.3848749157825748,4394]
["High","P63096-1","Guanine nucleotide-binding protein G(i) subunit alpha-1 [OS=Homo sapiens]",30,9,17,4,354,40.3,5.97,37.11,"cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","Gnai1; GNAI1; LOC101343271; LOC111155312","ENSANAG00000026023; ENSBTAG00000002714; ENSCANG00000034777; ENSCCAG00000031786; ENSCGRG00001015780; ENSCGRG00015010768; ENSCHIG00000023476; ENSCSAG00000011871; ENSFCAG00000007172; ENSG00000127955; ENSGGOG00000008064; ENSLAFG00000022531; ENSLCNG00005007413; ENSMMUG00000023470; ENSMNEG00000038772; ENSMPUG00000018288; ENSMUSG00000057614; ENSPCTG00005000350; ENSPTRG00000019343; ENSSSCG00000015407; ENSSSCG00070000597; ENSSSUG00005001506; ENSTSYG00000026142; ENSTTRG00000006465; ENSVVUG00000019537","Calcium regulation in cardiac cell; G protein signaling pathways; S1P receptor signal transduction; Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Chemokine signaling pathway; G protein signaling pathways; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Common pathways underlying drug addiction; Nicotine activity on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone; G protein signaling pathways; Cell-type dependent selectivity of CCK2R signaling; Chemokine signaling pathway; Purinergic signaling; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Calcium regulation in cardiac cells; Signal transduction of S1P receptor; Serotonin HTR1 group and FOS pathway; Calcium regulation in cardiac cells; G protein signaling pathways","G alpha (i) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Extra-nuclear estrogen signaling; G alpha (i) signalling events; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Adenylate cyclase inhibitory pathway; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion; Adenylate cyclase inhibitory pathway; G alpha (i) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12","Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Axon guidance; Apelin signaling pathway; Gap junction; Platelet activation; Leukocyte transendothelial migration; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Long-term depression; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Gastric acid secretion; Parkinson disease; Cocaine addiction; Morphine addiction; Alcoholism; Pertussis; Chagas disease; Toxoplasmosis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Chemical carcinogenesis",243.7,279.1,264.7,199.5,270.9,230.6,1.12339514978602,0.16786547926401799,0.27972922010049517,0.5532621654998113,0.4644111738347153,0.3330973395872554,4703]
["High","P63167","Dynein light chain 1, cytoplasmic [OS=Homo sapiens]",45,3,7,2,89,10.4,7.4,14.67,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","DYNLL1","ENSG00000088986","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome","Neutrophil degranulation; MHC class II antigen presentation; COPI-mediated anterograde transport; HCMV Early Events; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria","Vasopressin-regulated water reabsorption; Salmonella infection",270.1,215.5,287.6,238.6,180.9,199.3,1.2495151906916615,0.32136844076220034,0.13551069307979255,0.868026433480956,0.2925262625288969,0.5338351375839403,3617]
["High","P63279","SUMO-conjugating enzyme ubc9 [OS=Homo sapiens]",6,1,9,1,158,18,8.66,16.67,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2I","ENSG00000103275","Androgen receptor signaling pathway; TGF-beta signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of RNA binding proteins; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Processing of DNA double-strand break ends; Formation of Incision Complex in GG-NER; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)","Nucleocytoplasmic transport; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; MicroRNAs in cancer",543.7,455.7,573,678.8,418,440,1.0231650182196772,0.03303884475856682,0.9021606753971347,0.04471610744252191,0.9451322358111939,0.02450742401413714,7453]
["High","P68133","Actin, alpha skeletal muscle [OS=Homo sapiens]",40,17,1318,3,377,42,5.39,2621.67,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTA1","ENSG00000143632","Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Malignant pleural mesothelioma","Striated Muscle Contraction","",17269.3,17195.6,17228.1,14796.9,14007.9,14323.1,1.1985976595197074,0.2613474618988315,2.433033037181375E-4,3.6138519939182747,0.012923212213817805,1.8886295240078155,147]
["High","P68431","Histone H3.1 [OS=Homo sapiens]",57,8,86,1,136,15.4,11.12,147.96,"cell organization and biogenesis","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","H3C1; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8","ENSG00000197153; ENSG00000197409; ENSG00000273983; ENSG00000274750; ENSG00000275379; ENSG00000275714; ENSG00000277775; ENSG00000278828; ENSG00000286522; ENSG00000287080","Histone modifications; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma","Estrogen-dependent gene expression; Transcriptional regulation by small RNAs; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; HATs acetylate histones; Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Amyloid fiber formation; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Transcriptional regulation of granulopoiesis; B-WICH complex positively regulates rRNA expression; SIRT1 negatively regulates rRNA expression; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Late Events; HCMV Early Events; Formation of the beta-catenin:TCF transactivating complex; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Meiotic recombination; Assembly of the ORC complex at the origin of replication; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Interleukin-7 signaling; RMTs methylate histone arginines; PKMTs methylate histone lysines","Neutrophil extracellular trap formation; Alcoholism; Shigellosis; Transcriptional misregulation in cancer; Systemic lupus erythematosus",4376.4,4596.4,5271.5,3966,4248.3,3727.4,1.1928201177386804,0.25437649499176773,0.06764425567495957,1.1697690776264473,0.18617072552346997,0.7300886087636643,2837]
["High","P78324","tyrosine-protein phosphatase non-receptor type substrate 1 [OS=Homo sapiens]",12,4,5,4,504,54.9,6.98,7.62,"cell adhesion;stress response;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","SIRPA","ENSG00000198053","Prolactin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Male infertility","Neutrophil degranulation; Cell surface interactions at the vascular wall; Signal regulatory protein family interactions","Osteoclast differentiation",129.3,126.9,123.1,207.2,153.8,195.9,0.6810917579457714,-0.554078921002774,0.022330212719969544,1.6511071397736612,0.0942965391657773,1.0255042462741988,1849]
["High","P78362-1","SRSF protein kinase 2 [OS=Homo sapiens]",22,15,40,11,688,77.5,4.97,74.58,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","SRPK2","ENSG00000135250","mRNA processing","Maturation of nucleoprotein","",1346.8,1251.4,1321.2,1317.1,1231.3,1294.2,1.0199864674959662,0.02855001160268196,0.5409545533783555,0.2668392192669217,0.701273975224672,0.15411227777886677,6023]
["High","P78368","casein kinase I isoform gamma-2 [OS=Homo sapiens]",10,4,6,1,415,47.4,9.06,10.9,"cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK1G2","ENSG00000133275","Hedgehog signaling pathway","Disassembly of the destruction complex and recruitment of AXIN to the membrane; Sphingolipid de novo biosynthesis","Hedgehog signaling pathway",369.8,388.7,327.8,357.3,384.8,374.1,0.9732126858985845,-0.0391729688530123,0.6394586999439108,0.19418749960701415,0.7744522303648295,0.1110053651594845,6447]
["High","P78536-1","Disintegrin and metalloproteinase domain-containing protein 17 [OS=Homo sapiens]",15,11,15,11,824,93,5.76,25,"cell adhesion;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM17","ENSG00000151694; ENSPPAG00000038185","Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Notch signaling; Copper homeostasis; Ebola virus infection in host; Soluble ACE2-mediated cell entry of SARS-CoV-2; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Notch signaling pathway","Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; Release of Hh-Np from the secreting cell; Growth hormone receptor signaling; Nuclear signaling by ERBB4; TNF signaling; CD163 mediating an anti-inflammatory response; Regulated proteolysis of p75NTR","Notch signaling pathway; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Coronavirus disease",502.7,496,514.5,510.4,533.3,502,0.9789739276703114,-0.03065765683737158,0.37273328603342615,0.4286018219090366,0.5566758793705033,0.2543975961589079,5228]
["High","P78563-1","Double-stranded RNA-specific editase 1 [OS=Homo sapiens]",1,1,2,1,741,80.7,9.01,3.57,"cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ADARB1","ENSG00000197381","","C6 deamination of adenosine; Formation of editosomes by ADAR proteins","",87.1,79.1,90.5,74.2,63,67.1,1.2564855604503182,0.32939409184219104,0.02058743699265372,1.6863977169677717,0.08975248913380247,1.046953498158168,1791]
["High","P81605","Dermcidin [OS=Homo sapiens]",16,2,3,2,110,11.3,6.54,2.57,"protein metabolism;stress response;other biological processes","non-structural extracellular","other molecular function","DCD","ENSG00000161634","","Antimicrobial peptides","",52.1,47,41.8,49.6,51.9,62.3,0.86019536019536,-0.21726374533137233,0.19497430773438065,0.7100226129672951,0.36932542328724993,0.4325907957518538,4122]
["High","P82912-1","28S ribosomal protein S11, mitochondrial [OS=Homo sapiens]",29,3,6,3,194,20.6,10.81,19.37,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS11","ENSG00000181991","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",275.8,269.3,265.4,290.9,300.4,291.8,0.9177896048012685,-0.12376462850173332,4.844985170207595E-3,2.3147075479231987,0.041986286580444954,1.376892534243626,901]
["Medium","P83369","U7 snRNA-associated Sm-like protein LSm11 [OS=Homo sapiens]",3,1,1,1,360,39.5,10.99,2.63,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","LSM11","ENSG00000155858","","RNA Polymerase II Transcription Termination; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","",80.2,66.9,62.6,27.7,24.4,27,2.651074589127687,1.406577261623801,1.2782900592422416E-3,2.8933705884036947,0.023877724360199575,1.6220070655200947,418]
["High","P84022","Mothers against decapentaplegic homolog 3 [OS=Homo sapiens]",10,4,8,1,425,48.1,7.15,23.23,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","SMAD3","ENSG00000166949","Androgen receptor signaling pathway; Cell cycle; AGE/RAGE pathway; Adipogenesis; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Ovarian infertility; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularisation processes; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; TGF-beta receptor signaling; DNA damage response (only ATM dependent)","Ub-specific processing proteases; Interleukin-37 signaling; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX3 regulates BCL2L11 (BIM) transcription; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates CDKN1A transcription; NOTCH4 Intracellular Domain Regulates Transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer","FoxO signaling pathway; Cell cycle; Endocytosis; Cellular senescence; Wnt signaling pathway; TGF-beta signaling pathway; Apelin signaling pathway; Hippo signaling pathway; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Th17 cell differentiation; AGE-RAGE signaling pathway in diabetic complications; Hepatitis B; Human T-cell leukemia virus 1 infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer; Chronic myeloid leukemia; Hepatocellular carcinoma; Gastric cancer; Inflammatory bowel disease; Diabetic cardiomyopathy",186.2,166.3,171.7,232.6,217.6,240.5,0.7589402055885334,-0.39794186998322,3.4632367224254764E-3,2.460517822129587,0.03591095926785939,1.444772993671652,753]
["High","P84103","Serine/arginine-rich splicing factor 3 [OS=Homo sapiens]",43,9,79,8,164,19.3,11.65,141.64,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SRSF3","ENSG00000112081","mRNA processing","mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection",2952.9,2942.2,2890.6,3026.4,2950.1,3123.2,0.9654933679132279,-0.05066174571822996,0.1228387334725597,0.9106646699944695,0.27505730741432355,0.5605768127118106,3487]
["High","P86397","Hydroxyacyl-thioester dehydratase type 2, mitochondrial [OS=Homo sapiens]",17,1,2,1,168,18.5,8.92,5.04,"other metabolic processes","mitochondrion;nucleus","other molecular function","HTD2","ENSG00000255154","Mitochondrial fatty acid synthesis pathway","Fatty acyl-CoA biosynthesis","Fatty acid biosynthesis; Metabolic pathways; Fatty acid metabolism",24.7,31.4,28.7,29.7,28.1,31.8,0.9464285714285715,-0.0794344674944048,0.5112420519150849,0.29137343074255223,0.6779514166700038,0.16880142741335932,5888]
["High","P98171-1","Rho GTPase-activating protein 4 [OS=Homo sapiens]",7,5,7,5,946,105,6.34,7.93,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","ARHGAP4","ENSG00000089820","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle","",489.4,453.1,439.9,432.1,412.3,407.8,1.1039770004791567,0.14271011628247737,0.05889496730583305,1.2299218149699132,0.16906320026615607,0.7719509143454765,2720]
["High","P98198-1","Phospholipid-transporting ATPase ID [OS=Homo sapiens]",4,3,6,3,1209,137.4,7.01,5.74,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi","transporter activity;other molecular function","ATP8B2","ENSG00000143515; ENSPPAG00000034141; ENSPTRG00000001382","Mesodermal commitment pathway; Complement system in neuronal development and plasticity","Ion transport by P-type ATPases","",173.3,147.6,165.9,162.2,171.7,174.8,0.9569490859052486,-0.06348592614890047,0.440192629053034,0.35635723390533103,0.6204014526436985,0.20732719397512536,5540]
["High","Q00341-1","Vigilin [OS=Homo sapiens]",48,53,183,52,1268,141.4,6.87,403.1,"other metabolic processes;transport","non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","HDLBP","ENSG00000115677","","HDL clearance","",6867.2,6921.9,6828.6,6906.4,7166.8,6984.7,0.9790957312932437,-0.03047816834758381,0.14709728040050093,0.8323953566264725,0.3070129819211738,0.5128432601660421,3741]
["High","Q00688","peptidyl-prolyl cis-trans isomerase FKBP3 [OS=Homo sapiens]",54,10,29,10,224,25.2,9.28,56.54,"protein metabolism;other metabolic processes","nucleus","other molecular function","FKBP3","ENSG00000100442","","","",1363.8,1314.4,1367.2,1648.9,1416.5,1349.8,0.916243884761732,-0.12619643051225202,0.2523965635140907,0.597916562490612,0.4349398296000927,0.3615708200111623,4531]
["High","Q01081","Splicing factor U2AF 35 kDa subunit [OS=Homo sapiens]",47,8,66,8,240,27.9,8.81,83.97,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","U2AF1","ENSG00000160201","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","Spliceosome; Shigellosis",2091.5,2142.7,2222.4,2320.7,2166.2,2260.8,0.9568593743053191,-0.0636211815656407,0.17500566826584518,0.7569478847039222,0.34445280005538675,0.46287028051943724,3967]
["High","Q01082-1","Spectrin beta chain, non-erythrocytic 1 [OS=Homo sapiens]",69,146,748,14,2364,274.4,5.57,1717.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SPTBN1","ENSG00000115306; ENSPPAG00000020369; ENSPTRG00000011924","TGF-beta signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways","RHOV GTPase cycle; RHOU GTPase cycle; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Signaling by FLT3 fusion proteins; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Nephrin family interactions; Interaction between L1 and Ankyrins","",29636.4,29195.7,29195.9,30518,30612.4,30555.3,0.9601061016058121,-0.058734247592949984,0.001227572560669114,2.910952827704515,0.023434930449155112,1.6301363310532213,409]
["High","Q01518-1","adenylyl cyclase-associated protein 1 [OS=Homo sapiens]",52,23,219,1,475,51.9,8.06,510.69,"cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CAP1","ENSG00000131236","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity","Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling","",194.1,188.6,194.8,196.5,199.9,201.9,0.9652348320240683,-0.05104811646417316,0.05104640367872371,1.2920348494145306,0.1553274824331546,0.808751696794805,2566]
["High","Q01780","exosome component 10 [OS=Homo sapiens]",34,27,72,27,885,100.8,8.46,142.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","EXOSC10","ENSG00000171824","","Major pathway of rRNA processing in the nucleolus and cytosol","RNA degradation",3171.2,3027.3,3033,3218.3,3295.4,3227.2,0.9477050375222,-0.07748998842152688,0.03273501940110688,1.484987397348028,0.11816691238272886,0.9275041121284842,2163]
["High","Q01844","RNA-binding protein EWS [OS=Homo sapiens]",7,4,36,4,656,68.4,9.33,89.93,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","EWSR1","ENSG00000182944","VEGFA-VEGFR2 signaling pathway","","Transcriptional misregulation in cancer",1241.2,1251.7,1277.2,1561.1,1298.1,1445.3,0.8758508537576956,-0.19124287673177154,0.08131716255830627,1.089817783830967,0.2105885257894711,0.6765652956485018,3015]
["High","Q01970-1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [OS=Homo sapiens]",34,32,82,32,1234,138.7,5.9,165.67,"other metabolic processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","other molecular function","PLCB3","ENSG00000149782","Alzheimer's disease and miRNA effects; S1P receptor signal transduction; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; GPR40 pathway; MAPK cascade; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; Calcium regulation in cardiac cells","G alpha (q) signalling events; Synthesis of IP3 and IP4 in the cytosol; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Inositol phosphate metabolism; Metabolic pathways; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Apelin signaling pathway; Gap junction; Platelet activation; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Pathways in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis",2985.6,3097.5,3010.7,3190.4,2968.5,3310.1,0.960375963670926,-0.0583287986979401,0.3020715862713653,0.5198901238028623,0.4886212856032361,0.31102761796291883,4827]
["High","Q02127","Dihydroorotate dehydrogenase (Quinone), mitochondrial [OS=Homo sapiens]",17,5,9,5,395,42.8,9.67,20.63,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","DHODH","ENSG00000102967","Pyrimidine metabolism","Pyrimidine biosynthesis","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",294.7,314.2,297.6,315.7,282.7,325.3,0.9813792356825809,-0.027117348134453108,0.7081949116847999,0.14984719793254242,0.8234677394541947,0.08435341027864118,6715]
["High","Q02318","Sterol 26-hydroxylase, mitochondrial [OS=Homo sapiens]",10,5,7,5,531,60.2,8.9,11.54,"other metabolic processes","other membranes;mitochondrion","other molecular function","CYP27A1","ENSG00000135929","Vitamin D metabolism; PPAR signaling pathway; Oxidation by cytochrome P450; Vitamin D-sensitive calcium signaling in depression; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Metapathway biotransformation Phase I and II","Endogenous sterols; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol; Defective CYP27A1 causes CTX","Primary bile acid biosynthesis; Metabolic pathways; PPAR signaling pathway; Cholesterol metabolism",322.8,320.1,310.7,415.5,473,409,0.73495183044316,-0.4442783976704437,0.005165887033824833,2.2868550950893245,0.04374755527126279,1.3590462114843185,922]
["High","Q02880","DNA topoisomerase 2-beta [OS=Homo sapiens]",39,55,218,39,1626,183.2,8,460.98,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP2B","ENSG00000077097","","SUMOylation of DNA replication proteins","Platinum drug resistance",5314.2,5453.3,5233.9,5935.7,6314.1,6231.4,0.8658204012726448,-0.20786029980243584,3.274058593610925E-3,2.484913552580096,0.03521191391035,1.4533103686215543,726]
["High","Q03013-1","glutathione S-transferase mu 4 [OS=Homo sapiens]",46,9,31,2,218,25.5,5.9,59.38,"other metabolic processes","non-structural extracellular;cytosol;other cell component","other molecular function","GSTM4","ENSG00000168765","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II","Glutathione conjugation; Biosynthesis of maresin conjugates in tissue regeneration (MCTR)","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",53.6,60.7,55.8,64.7,60.9,64.6,0.8943217665615144,-0.16113410519717808,0.05175120962782252,1.286079494594738,0.1563146788294152,0.8060002373660639,2585]
["High","Q03135","Caveolin-1 [OS=Homo sapiens]",27,4,6,4,178,20.5,6.02,10.73,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","CAV1","ENSG00000105974","Androgen receptor signaling pathway; Integrin-mediated cell adhesion; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host; Acute viral myocarditis; EGF/EGFR signaling pathway; Congenital generalized lipodystrophy (CGL)","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RND1 GTPase cycle; RHOH GTPase cycle; Basigin interactions; Triglyceride catabolism; RHOD GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; NOSTRIN mediated eNOS trafficking; RND3 GTPase cycle; Disassembly of the destruction complex and recruitment of AXIN to the membrane; FOXO-mediated transcription of cell cycle genes; VEGFR2 mediated vascular permeability; eNOS activation","Endocytosis; Focal adhesion; Prion disease; Bacterial invasion of epithelial cells; Proteoglycans in cancer; Viral myocarditis; Fluid shear stress and atherosclerosis",360.3,366.8,409.9,431,405,409.1,0.9131796642839933,-0.1310293625294147,0.1090281964281609,0.96246117206327,0.2542688643103585,0.594706816725857,3348]
["High","Q03426","mevalonate kinase [OS=Homo sapiens]",15,4,12,4,396,42.4,6.46,11.91,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","MVK","ENSG00000110921","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Terpenoid backbone biosynthesis; Metabolic pathways; Peroxisome",262.2,268.9,281.5,292.5,291.9,287,0.932522377782878,-0.1007897486840799,0.02962648636571891,1.528319851809296,0.11084025181769681,0.9553024962161146,2087]
["High","Q04726","Transducin-like enhancer protein 3 [OS=Homo sapiens]",20,13,23,10,772,83.4,7.2,57.7,"cell-cell signaling;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","TLE3","ENSG00000140332","White fat cell differentiation","Estrogen-dependent gene expression; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes","Wnt signaling pathway; Notch signaling pathway",825,881.9,866.2,895.4,944,917.8,0.9332293631220081,-0.09969639390466312,0.04950149547275209,1.30538168054616,0.15240838984670674,0.8169911250972197,2536]
["High","Q04727-1","Transducin-like enhancer protein 4 [OS=Homo sapiens]",16,10,20,2,773,83.7,7.5,44.85,"cell-cell signaling;signal transduction;other biological processes","nucleus;other cell component","other molecular function","TLE4","ENSG00000106829","","Formation of the beta-catenin:TCF transactivating complex; NOTCH1 Intracellular Domain Regulates Transcription; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes","Wnt signaling pathway; Notch signaling pathway",173.4,158.1,161.4,162.4,138.8,155.2,1.0799737072743205,0.11099618938254857,0.2205791711261288,0.656435499566114,0.3996014311259429,0.3983729650682101,4310]
["High","Q05086","Ubiquitin-protein ligase E3A [OS=Homo sapiens]",27,22,39,22,875,100.6,5.22,96.32,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE3A","ENSG00000114062","Androgen receptor signaling pathway; MECP2 and associated Rett syndrome; Prader-Willi and Angelman syndrome; Synaptic signaling pathways associated with autism spectrum disorder","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis; Human papillomavirus infection; Viral carcinogenesis",1470.7,1458,1511.8,1375.7,1394.9,1382.5,1.06920131949628,0.09653352311783839,0.005070973725730769,2.2949086396591283,0.0432723091262359,1.363789929066941,915]
["High","Q05519","serine/arginine-rich splicing factor 11 [OS=Homo sapiens]",28,15,76,15,484,53.5,10.52,131.75,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","SRSF11","ENSG00000116754","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",4234.5,4275,4395.1,4439.4,4453.4,4532.7,0.961200700160143,-0.05709039552778297,0.036777435882083084,1.4344185529957327,0.12751253080253316,0.894447134516406,2252]
["High","Q05932-1","Folylpolyglutamate synthase, mitochondrial [OS=Homo sapiens]",13,5,5,5,587,64.6,7.94,9.7,"cell cycle OR cell proliferation;other metabolic processes;developmental processes","other membranes;cytosol;mitochondrion;other cell component","other molecular function","FPGS","ENSG00000136877","Fluoropyrimidine activity","","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance",145.6,129.5,154.3,93.2,81.9,90.4,1.617325800376648,0.6936103301672574,0.002426797756094299,2.6149664152923187,0.030810466470868755,1.5113017264091,615]
["High","Q06203","amidophosphoribosyltransferase [OS=Homo sapiens]",43,16,53,16,517,57.4,6.76,119.08,"cell cycle OR cell proliferation;other metabolic processes;transport;developmental processes;other biological processes","cytosol","other molecular function","PPAT","ENSG00000128059","Fluoropyrimidine activity; Metabolic reprogramming in colon cancer","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Alanine, aspartate and glutamate metabolism; Metabolic pathways",1700.8,1886.9,1725.6,1677.8,1750.9,1759,1.0242111147522022,0.03451312042955169,0.5475172741741958,0.26160217427745847,0.705564429237848,0.15146332211535285,6059]
["High","Q06546","GA-binding protein alpha chain [OS=Homo sapiens]",27,8,23,8,454,51.3,4.97,65,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GABPA","ENSG00000154727","Energy metabolism; Allograft rejection; Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression; Malignant pleural mesothelioma","Transcriptional activation of mitochondrial biogenesis","",661.6,692,698.6,780,731.6,743.2,0.9101472414404824,-0.13582813494711896,0.021805962552869023,1.6614247380585159,0.09298796046575714,1.031573277701577,1831]
["High","Q06787","synaptic functional regulator FMR1 [OS=Homo sapiens]",16,10,25,2,632,71.1,7.42,45.38,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","FMR1","ENSG00000102081","Serotonin and anxiety; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome","","",837.3,803.6,770.8,889,881.5,868.1,0.9140074281816115,-0.1297222047055201,0.019877465607517318,1.70163898929663,0.08773502061249022,1.0568270175477177,1769]
["High","Q07065","Cytoskeleton-associated protein 4 [OS=Homo sapiens]",67,40,173,40,602,66,5.92,454.28,"","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","","CKAP4","ENSG00000136026","","Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RND2 GTPase cycle; RND3 GTPase cycle; Surfactant metabolism","Protein processing in endoplasmic reticulum",7875.7,7795.5,8061,8886.8,8626.8,8541.2,0.9108571165389872,-0.13470333441421198,0.004024419301107344,2.3952967767914903,0.03850816899883106,1.4144471308867161,816]
["High","Q07820","Induced myeloid leukemia cell differentiation protein Mcl-1 [OS=Homo sapiens]",49,10,31,10,350,37.3,5.66,88.8,"stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","transporter activity;other molecular function","MCL1","ENSG00000143384","Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-Akt signaling pathway; MicroRNA network associated with chronic lymphocytic leukemia; Host-pathogen interaction of human coronaviruses - apoptosis; Malignant pleural mesothelioma","Interleukin-4 and Interleukin-13 signaling","PI3K-Akt signaling pathway; Apoptosis; JAK-STAT signaling pathway; MicroRNAs in cancer",909.6,883.9,917.2,829.5,792,816.9,1.111671587926509,0.15273064737067205,3.6993015094192996E-3,2.431880270322712,0.03722183786797151,1.4292021869222649,776]
["High","Q07954","prolow-density lipoprotein receptor-related protein 1 [OS=Homo sapiens]",19,65,111,65,4544,504.3,5.39,219.85,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","LRP1","ENSG00000123384","Alzheimer's disease and miRNA effects; Regulation of Wnt / B-catenin signaling by small molecule compounds; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Alzheimer's disease","Retinoid metabolism and transport; Scavenging of heme from plasma","Cholesterol metabolism; Alzheimer disease; Malaria",3459.5,3476.7,3520.5,3980.1,3983.7,4102.8,0.8665821358129053,-0.20659159845733366,2.6441732175929209E-4,3.5777100979834184,0.013066901571497168,1.8838273802792056,158]
["High","Q08345-1","Epithelial discoidin domain-containing receptor 1 [OS=Homo sapiens]",1,1,1,1,913,101.1,6.83,3.57,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","DDR1","ENSG00000137332; ENSG00000204580; ENSG00000215522; ENSG00000230456; ENSG00000234078; ENSPPAG00000026163; ENSPTRG00000017942","Interactions between LOXL4 and oxidative stress pathway","Non-integrin membrane-ECM interactions","",54.4,50.6,65.7,99.3,65.5,79.6,0.6984451718494271,-0.5177812267909916,0.08528265719881636,1.0691392765538412,0.2169012988300841,0.6637378473723924,3070]
["High","Q08623","Pseudouridine-5'-phosphatase [OS=Homo sapiens]",12,2,7,2,228,25.2,5.31,11.08,"other metabolic processes","cytosol","other molecular function","PUDP","ENSG00000130021","","Pyrimidine salvage","",166.8,148.9,141.8,156.9,154.9,165.3,0.958918465730455,-0.06051994292553748,0.4647000862111648,0.3328272469508073,0.641396194650305,0.1928736210325811,5657]
["High","Q08AD1","Calmodulin-regulated spectrin-associated protein 2 [OS=Homo sapiens]",15,15,19,15,1489,168,6.8,35.55,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi","cytoskeletal activity;other molecular function","CAMSAP2","ENSG00000118200","","","",474.5,477,495.8,546.3,501.6,495.8,0.937552633283669,-0.09302841063588548,0.13703107955469382,0.8631809208121598,0.29458663798542106,0.530786956002572,3632]
["High","Q09028","Histone-binding protein RBBP4 [OS=Homo sapiens]",38,15,119,8,425,47.6,4.89,322.27,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBBP4","ENSG00000162521","Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Malignant pleural mesothelioma","RNA Polymerase I Transcription Initiation; HCMV Early Events; Transcriptional Regulation by E2F6; G1/S-Specific Transcription; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1","Cellular senescence",2730.2,2579.7,2490.3,2451.7,2466.7,2544.6,1.0451829023181027,0.06375542955756058,0.21171295006500715,0.6742525762282945,0.3895957374752712,0.409385803336275,4243]
["Medium","Q09328","Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A [OS=Homo sapiens]",1,1,1,1,741,84.5,8.12,2.01,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","MGAT5","ENSG00000152127","","N-Glycan antennae elongation; Maturation of spike protein","N-Glycan biosynthesis; Metabolic pathways",67.6,73.5,69.9,53.9,60.8,56.3,1.2339181286549707,0.3032466738212873,0.007354274823736225,2.133460144904739,0.05201284223164171,1.2838894136392835,1104]
["High","Q0VG06","Fanconi anemia core complex-associated protein 100 [OS=Homo sapiens]",8,4,5,4,881,93.4,5.29,13.18,"DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","nucleic acid binding activity","FAAP100","ENSG00000185504","DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",158.8,153.2,150.6,151.4,132.7,140.6,1.0892394631504592,0.12332115728878856,0.1003762055794153,0.9983692255404775,0.24085353815736776,0.618246969482682,3254]
["High","Q10589","bone marrow stromal antigen 2 [OS=Homo sapiens]",22,4,16,4,180,19.8,5.6,37.57,"stress response;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","BST2","ENSG00000130303","Ebola virus infection in host; Host-pathogen interaction of human coronaviruses - MAPK signaling","Neutrophil degranulation; Interferon alpha/beta signaling","Herpes simplex virus 1 infection; Human immunodeficiency virus 1 infection",537.4,574.6,580.8,853.7,835.5,819.3,0.6748255929838549,-0.5674134055376333,8.5351347704107941E-5,4.0687896169530395,0.008029196661128613,2.0953279046704782,83]
["High","Q12767","Transmembrane protein 94 [OS=Homo sapiens]",2,2,2,2,1356,151.1,6.44,7.02,"","other membranes","","TMEM94","ENSG00000177728","","","",42.9,40,49.7,48.9,50,43.9,0.9285714285714287,-0.10691520391651173,0.3780691971831866,0.42242870491282386,0.5613166555630958,0.2507920710676458,5259]
["High","Q12797","Aspartyl/Asparaginyl beta-hydroxylase [OS=Homo sapiens]",32,18,71,18,758,85.8,5.01,161.12,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","ASPH","ENSG00000198363","","Stimuli-sensing channels; Ion homeostasis","Calcium signaling pathway; Cardiac muscle contraction",2518.1,2508.8,2457,2415.3,2360.7,2398.9,1.0430668023247711,0.06083155699139064,0.014530280202382511,1.8377260106727153,0.07352717292300884,1.1335521320772284,1543]
["High","Q12824-1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [OS=Homo sapiens]",43,14,64,14,385,44.1,6.23,125.24,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101347788; LOC111142756; Smarcb1; SMARCB1","ENSCAFG00000014105; ENSCATG00000029590; ENSCCAG00000036123; ENSCHIG00000019816; ENSCSAG00000011285; ENSDLEG00000015913; ENSECAG00000007797; ENSG00000099956; ENSG00000275837; ENSHGLG00000019077; ENSMFAG00000040790; ENSMLUG00000004975; ENSMMUG00000009098; ENSMNEG00000033936; ENSMUSG00000000902; ENSPANG00000026464; ENSPPAG00000028391; ENSRBIG00000027964; ENSRFEG00010017090; ENSRROG00000030710; ENSSBOG00000031674; ENSSSCG00000010070; ENSSSCG00070020965; ENSSSUG00005014167; ENSSTOG00000012408; ENSTSYG00000008262; ENSUAMG00000010813","TNF-alpha NF-kB signaling pathway; Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation","RMTs methylate histone arginines; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",1497.6,1457.9,1446.9,1584.6,1512.9,1572.4,0.9427182594916379,-0.0851014229968347,0.029778236055687614,1.5261010317003745,0.11098256187246248,0.9547452543440531,2095]
["High","Q12851","Mitogen-activated protein kinase kinase kinase kinase 2 [OS=Homo sapiens]",8,5,7,5,820,91.5,6.34,12.27,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","kinase activity;other molecular function","MAP4K2","ENSG00000168067","TNF-alpha signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma","","MAPK signaling pathway",93.8,110.5,85.6,105.5,116.1,107.3,0.8814229249011858,-0.1820936747740054,0.18055553713533867,0.7433891884310105,0.351302674795097,0.45431854350621387,4013]
["High","Q12887","Protoheme IX farnesyltransferase, mitochondrial [OS=Homo sapiens]",4,1,1,1,443,48.9,9.19,2.28,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","COX10","ENSG00000006695","Mitochondrial complex IV assembly","Heme biosynthesis","Oxidative phosphorylation; Porphyrin metabolism; Metabolic pathways; Biosynthesis of cofactors; Thermogenesis",19.7,27.1,31.7,18,19.1,20.7,1.3581314878892734,0.4416231612783106,0.12636865424553956,0.8983606394748543,0.2799110503118221,0.5529799561436364,3525]
["High","Q12906-7","Isoform 7 of Interleukin enhancer-binding factor 3 [OS=Homo sapiens]",68,50,542,3,898,95.7,8.81,1315.87,"","","","ILF3","","","","",22603.1,22142.9,22719.5,24101.6,23152.1,23981,0.9470875851235424,-0.07843024492708124,0.022236592898244336,1.652931754807833,0.0940538013810898,1.026623646839091,1846]
["High","Q12959","Disks large homolog 1 [OS=Homo sapiens]",24,18,28,16,904,100.4,5.76,72.85,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","DLG1","ENSG00000075711","Brain-derived neurotrophic factor (BDNF) signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Disruption of postsynaptic signaling by CNV; 3q29 copy number variation syndrome","Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; NrCAM interactions; Activation of Ca-permeable Kainate Receptor","Hippo signaling pathway; Tight junction; T cell receptor signaling pathway; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Viral carcinogenesis",1264.5,1243.9,1285.5,1442.2,1413.4,1433.8,0.8844826782300554,-0.17709420553443259,3.6141863151521367E-4,3.4419894628551124,0.01403958544711835,1.8526457156169658,201]
["High","Q12974","Protein tyrosine phosphatase type IVA 2 [OS=Homo sapiens]",19,3,6,2,167,19.1,8.37,8.28,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PTP4A2","ENSG00000184007","","RAB geranylgeranylation","",225.2,251.8,225.9,219.8,234.3,230.5,1.0267309377738825,0.03805816257445371,0.5662240239836256,0.24701170815674986,0.7192251796427768,0.14313511661897188,6147]
["High","Q12999","Tetraspanin-31 [OS=Homo sapiens]",3,1,2,1,210,23,7.97,5.24,"other biological processes","plasma membrane;other membranes","","TSPAN31","ENSG00000135452","","","",120.3,117.2,84,104.1,108,123.8,0.957130098243525,-0.0632130580191886,0.7323492445450248,0.13528176210087506,0.839921107727314,0.07576150451877112,6808]
["High","Q13045-1","protein flightless-1 homolog [OS=Homo sapiens]",36,36,80,36,1269,144.7,6.05,191.17,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLII","ENSG00000177731; ENSG00000284571","VEGFA-VEGFR2 signaling pathway","","",3679.9,3651.8,3713.8,3680,3707.7,3631,1.0024322288473233,0.003504704100777246,0.77120200652667,0.11283184914888883,0.8670331557898113,0.06196429456388781,6945]
["High","Q13111-1","Chromatin assembly factor 1 subunit A [OS=Homo sapiens]",25,17,31,17,956,106.9,5.94,52.65,"","","","","","","","",1198.4,1237.4,1149.2,1497.2,1402.2,1501.9,0.8145320700702064,-0.2959565926738213,2.7495590826269304E-3,2.5607369437459986,0.03209051915867126,1.4936232568551862,669]
["High","Q13123","Protein Red [OS=Homo sapiens]",31,14,58,14,557,65.6,6.64,127.66,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","IK","ENSG00000113141","","","",2343.4,2435.8,2599.2,3251.5,3080.8,2900.9,0.7991162327253822,-0.3235227341863803,0.007971124993029821,2.0984803807637347,0.0538395708871772,1.2688984101896092,1156]
["High","Q13136","Liprin-alpha-1 [OS=Homo sapiens]",23,27,39,22,1202,135.7,6.29,100.62,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;other cell component","","PPFIA1","ENSG00000131626","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",2173.2,1927,2171.9,2109.1,1934.8,2052.2,1.0288709174718265,0.04106199252847052,0.5764562497850672,0.2392336479493878,0.7267835295207176,0.13859492330032372,6193]
["High","Q13158","FAS-associated death domain protein [OS=Homo sapiens]",48,7,28,7,208,23.3,5.69,60.07,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","FADD","ENSG00000168040","TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor (RLR) pathway; VEGFA-VEGFR2 signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Alzheimer's disease; Toll-like receptor signaling pathway","Regulation of TNFR1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL  signaling; TLR3-mediated TICAM1-dependent programmed cell death; TNFR1-induced proapoptotic signaling; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis","Platinum drug resistance; Apoptosis; Apoptosis; Necroptosis; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Alcoholic liver disease; Alzheimer disease; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Salmonella infection; Chagas disease; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",887.4,835.2,900.2,874.7,886.1,856.1,1.0022545760250678,0.00324900446159583,0.9321978220411329,0.03049191607477277,0.9639253866371561,0.01595658168416251,7551]
["High","Q13206","probable ATP-dependent RNA helicase DDX10 [OS=Homo sapiens]",22,18,36,18,875,100.8,8.63,70.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX10","ENSG00000178105","","","",1491,1604.3,1543.4,1569.5,1632.9,1658.6,0.9542686689981488,-0.06753258875951275,0.15323405369060938,0.8146447093348871,0.3148556555832311,0.5018885012930618,3800]
["High","Q13257-1","Mitotic spindle assembly checkpoint protein MAD2A [OS=Homo sapiens]",35,8,25,8,205,23.5,5.08,53.29,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD2L1","ENSANAG00000022503; ENSCANG00000042550; ENSCATG00000040684; ENSCCAG00000030445; ENSG00000164109; ENSGGOG00000002516; ENSMLEG00000036707; ENSMMUG00000054168; ENSMNEG00000040691; ENSPANG00000019721; ENSPPAG00000028274; ENSPTRG00000016401; ENSRBIG00000035049; ENSRROG00000029952; ENSSBOG00000031396","Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; Cell cycle","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection",1286.6,1360.6,1270,1371.3,1604.7,1469.5,0.8811607243279722,-0.18252290316228553,0.07380478235432032,1.1319154961335989,0.19721688590777997,0.7050559030732414,2922]
["High","Q13283","Ras GTPase-activating protein-binding protein 1 [OS=Homo sapiens]",45,15,98,14,466,52.1,5.52,224.81,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","G3BP1","ENSG00000145907","","","",4205.6,4280,4529.3,4686.6,4104.8,4375.9,0.9884258731858467,-0.016795319521789354,0.8068541100339789,0.09320498440427029,0.8891908103239671,0.05100503432911412,7085]
["High","Q13362","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [OS=Homo sapiens]",13,7,13,4,524,61,6.87,26.83,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","PPP2R5C","ENSG00000078304","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)","Platelet sensitization by LDL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF activation; Negative regulation of MAPK pathway; CTLA4 inhibitory signaling","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; Dopaminergic synapse; Human papillomavirus infection",395.6,387.9,409,413,424.2,421.6,0.9473307912297424,-0.07805981751818787,0.03476284774144207,1.4588846537499613,0.1227071949209673,0.9111299717239867,2212]
["High","Q13367","AP-3 complex subunit beta-2 [OS=Homo sapiens]",23,20,42,15,1082,119,5.59,85.06,"transport","other membranes;ER/Golgi;other cell component","","AP3B2","ENSG00000103723","","","Lysosome",1333.7,1275,1286.9,942.7,991.9,977.3,1.3378206669185069,0.41988473758827055,1.4312393838825148E-4,3.84428772165287,0.010159197372140613,1.9931406021524594,110]
["High","Q13418","Integrin-linked protein kinase [OS=Homo sapiens]",24,12,25,12,452,51.4,8.07,41.21,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ILK","ENSG00000166333","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; PPAR signaling pathway; Eukaryotic transcription initiation; Endometrial cancer; Acute viral myocarditis; Genes controlling nephrogenesis; Development of ureteric collection system","Localization of the PINCH-ILK-PARVIN complex to focal adhesions","PPAR signaling pathway; Axon guidance; Focal adhesion; Bacterial invasion of epithelial cells; Shigellosis; Endometrial cancer",1227.6,1217.4,1208.6,1250.4,1184.9,1204,1.003929327068392,5.657712439423806E-3,0.8251105674185051,0.08348785072006924,0.9002883329239362,0.04561837795676926,7156]
["High","Q13435","Splicing factor 3b subunit 2 [OS=Homo sapiens]",49,43,282,43,895,100.2,5.67,582.83,"RNA metabolism OR transcription;other metabolic processes","nucleus","","SF3B2","ENSG00000087365","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",11014.2,10251.3,10864.9,12136,11089.1,11247.6,0.932053480000116,-0.1015153576930255,0.12322052364674228,0.9093169499298238,0.27551713878401024,0.5598513803047205,3492]
["High","Q13438-1","Protein os-9 [OS=Homo sapiens]",35,22,48,22,667,75.5,4.87,78.4,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;ER/Golgi","other molecular function","OS9","ENSG00000135506","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",1499.8,1380.6,1510.8,1343.4,1285,1272,1.125833247872013,0.17099315931570058,0.025531250361797698,1.5929279156331995,0.10238726390596632,0.9897540624945957,1947]
["High","Q13464","Rho-associated protein kinase 1 [OS=Homo sapiens]",27,35,47,31,1354,158.1,5.9,89.19,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function","ROCK1","ENSG00000067900","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; G13 signaling pathway","Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse; EPHB-mediated forward signaling; RND3 GTPase cycle; RHOBTB1 GTPase cycle; Potential therapeutics for SARS; VEGFA-VEGFR2 Pathway; Apoptotic cleavage of cellular proteins; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; RHOH GTPase cycle","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; TGF-beta signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer",2198.6,2100.1,2102.2,2247.5,2174.3,2067.3,0.9864079764528209,-0.019743628943851656,0.6580223576651252,0.18175935008568764,0.7880120504063339,0.10346714115897244,6520]
["High","Q13492-1","Phosphatidylinositol-binding clathrin assembly protein [OS=Homo sapiens]",18,10,25,9,652,70.7,7.9,40.14,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PICALM","ENSG00000073921","","Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; RND3 GTPase cycle","",825.3,828.4,832.2,862,890.6,867.9,0.9486357565350123,-0.07607384653788703,7.402394044701565E-3,2.1306278002346124,0.05211712597027035,1.283019541725137,1109]
["High","Q13501-1","sequestosome-1 [OS=Homo sapiens]",58,14,59,14,440,47.7,5.22,141.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","SQSTM1","ENSG00000161011","IL-1 signaling pathway; RANKL/RANK signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Interleukin-1 induced activation of NF-kB; Clear cell renal cell carcinoma pathways; CAMKK2 pathway; 7q11.23 copy number variation syndrome","Interleukin-1 signaling; Signaling by ALK fusions and activated point mutants; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; PINK1-PRKN Mediated Mitophagy; NRIF signals cell death from the nucleus; Pexophagy","Mitophagy; Autophagy; Necroptosis; Cellular senescence; Osteoclast differentiation; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Shigellosis; Fluid shear stress and atherosclerosis",1914.4,1685,1811.7,1414.1,1411,1386.8,1.2847171110425226,0.36145071939880274,3.9425464525247806E-3,2.404223180952431,0.03833549526938168,1.4163989215724764,803]
["High","Q13555-8","Isoform 8 of Calcium/calmodulin-dependent protein kinase type II subunit gamma [OS=Homo sapiens]",22,9,21,7,556,62.1,7.42,36.99,"protein metabolism;other metabolic processes;other biological processes","other cell component","kinase activity;other molecular function","CAMK2G; LOC111145432","ENSCATG00000041481; ENSECAG00000000031; ENSFCAG00000018407; ENSG00000148660; ENSLCNG00005022562; ENSMPUG00000003376; ENSPANG00000022457; ENSPTRG00000002643","Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway; Calcium regulation in cardiac cells","","ErbB signaling pathway; Calcium signaling pathway; cAMP signaling pathway; HIF-1 signaling pathway; Oocyte meiosis; Necroptosis; Adrenergic signaling in cardiomyocytes; Wnt signaling pathway; Axon guidance; Circadian entrainment; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Dopaminergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Melanogenesis; Oxytocin signaling pathway; Glucagon signaling pathway; Aldosterone synthesis and secretion; Cushing syndrome; Gastric acid secretion; Parkinson disease; Pathways of neurodegeneration; Amphetamine addiction; Tuberculosis; Pathways in cancer; Proteoglycans in cancer; Glioma; Diabetic cardiomyopathy; Lipid and atherosclerosis",777.3,831.3,858.7,761.5,799.2,791.3,1.0490221088435374,0.06904508399984281,0.22093909972848683,0.6557274199652056,0.3999750731926791,0.3979670734525219,4313]
["High","Q13573","SNW domain-containing protein 1 [OS=Homo sapiens]",19,10,17,10,536,61.5,9.52,28.8,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SNW1","ENSG00000100603","TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; mRNA Splicing - Major Pathway; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling","Spliceosome; Notch signaling pathway; Epstein-Barr virus infection; Viral carcinogenesis",445.6,500.9,477.8,1244.7,647.7,493.2,0.5970405767940979,-0.7440991098792015,0.23547447758145107,0.6280561579457605,0.41596939388144116,0.380938622636217,4420]
["High","Q13574","Diacylglycerol kinase zeta [OS=Homo sapiens]",13,10,17,10,1117,124.1,9.04,42.38,"","","","","","","","",593.6,616.4,593.1,626.5,626,621.7,0.962063813893928,-0.05579550345448743,0.03896461503185469,1.4093296102079917,0.13216147444340634,0.8788951248431294,2302]
["High","Q13615","myotubularin-related protein 3 [OS=Homo sapiens]",4,4,4,4,1198,133.5,5.8,7.86,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;other cell component","other molecular function","MTMR3","ENSG00000100330","","Synthesis of PIPs at the plasma membrane; Macroautophagy","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Autophagy",239.8,187.6,195.8,180,157.3,185.4,1.1922709010904917,0.25371207410177665,0.14197684594001575,0.8477824760422765,0.30042146696467287,0.5222690375427015,3690]
["High","Q13636","ras-related protein rab-31 [OS=Homo sapiens]",17,3,4,3,194,21.6,7.06,11.98,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB31","ENSG00000168461","","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","Endocytosis",244.5,267,277.3,280.2,280.9,245.1,0.9784172661870505,-0.03147823147316783,0.7235393479887933,0.14053784581690448,0.8339821714048565,0.07884323346688055,6774]
["High","Q13637","Ras-related protein Rab-32 [OS=Homo sapiens]",9,2,2,2,225,25,6.54,5.58,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB32","ENSG00000118508","","RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","",166.3,191.6,170.4,183.5,180.6,177.7,0.9750830564784053,-0.03640298364964986,0.6045294871957042,0.21858251066085496,0.7488761281967411,0.12559001312783452,6303]
["High","Q13794","phorbol-12-myristate-13-acetate-induced protein 1 [OS=Homo sapiens]",41,2,3,2,54,6,10.29,7.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus","","PMAIP1","ENSG00000141682","miRNA regulation of DNA damage response; TP53 network; Apoptosis modulation and signaling; Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; miRNA regulation of p53 pathway in prostate cancer; Chromosomal and microsatellite instability in colorectal cancer ; Unfolded protein response; p53 transcriptional gene network; DNA damage response; DNA damage response (only ATM dependent)","TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation of NOXA and translocation to mitochondria","Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Pathways in cancer; Viral carcinogenesis; Colorectal cancer",112.1,93,104.6,82.4,74.5,78.4,1.31619209519762,0.3963700624503655,0.014501167743617257,1.8385970236830151,0.07352280372867763,1.1335779398608428,1540]
["High","Q13838-1","spliceosome RNA helicase DDX39B [OS=Homo sapiens]",60,24,220,12,428,49,5.67,471.31,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BAT1; DDX39B; LOC101341139","ENSANAG00000030372; ENSCANG00000041217; ENSCCAG00000027897; ENSCJAG00000003152; ENSECAG00000007750; ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439; ENSGGOG00000005989; ENSMFAG00000034233; ENSMICG00000017349; ENSMLEG00000043791; ENSMMUG00000008839; ENSMNEG00000041059; ENSMODG00000015791; ENSOANG00000008361; ENSPANG00000018609; ENSPCOG00000018656; ENSPCTG00005013682; ENSPPAG00000043072; ENSPPYG00000016433; ENSPTRG00000032509; ENSRROG00000039517; ENSSHAG00000003209; ENSSSCG00000001400; ENSSSCG00005031872; ENSSSCG00015055352; ENSSSCG00025077755; ENSSSCG00030066086; ENSSSCG00035021438; ENSSSCG00040071129; ENSSSCG00045038130; ENSSSCG00050005792; ENSSSCG00055028973; ENSSSCG00060042375; ENSSSCG00065025136; ENSSSCG00070024145; ENSVURG00010001931","","Transport of Mature mRNA derived from an Intron-Containing Transcript; RHOBTB2 GTPase cycle; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",8817,9112.5,8698.2,8848.6,9755.1,9439.4,0.9495276913037433,-0.07471802023766251,0.1824373456667965,0.7388862550599598,0.3527664177727457,0.45251276500894483,4038]
["High","Q13884","Beta-1-syntrophin [OS=Homo sapiens]",2,1,1,1,538,58,8.63,2.76,"other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SNTB1","ENSG00000172164","IL-18 signaling pathway","","",43.1,39.1,39.3,42.1,41.1,45.3,0.9455252918287937,-0.08081204558809724,0.2681878005720244,0.5715609813865539,0.45246550278011377,0.3444145270076305,4628]
["High","Q13952-1","Nuclear transcription factor Y subunit gamma [OS=Homo sapiens]",11,5,13,5,458,50.3,6.1,18.92,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFYC","ENSG00000066136","","PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum  stress; ATF6 (ATF6-alpha) activates chaperone genes","Antigen processing and presentation; Tuberculosis",562.8,553.5,572.9,590.7,533,542.5,1.013803865082223,0.019778569261299863,0.7031171517172268,0.15297230783154597,0.8202508173626336,0.08605332817641073,6693]
["High","Q14011","Cold-inducible RNA-binding protein [OS=Homo sapiens]",46,7,37,2,172,18.6,9.51,75.64,"cell organization and biogenesis;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CIRBP","ENSG00000099622","","","",1845.6,1801.3,1874.2,1402.9,1329.4,1408,1.333502403207497,0.41522042488315025,1.5478745160942077E-4,3.810264249839682,0.010071503518052978,1.9969056912286711,120]
["High","Q14108-1","Lysosome membrane protein 2 [OS=Homo sapiens]",13,6,21,6,478,54.3,5.14,38.78,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCARB2","ENSG00000138760","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome","Cargo recognition for clathrin-mediated endocytosis","Lysosome",951.6,938.8,908,870.5,874.9,869.5,1.0701747676775404,0.09784641893733217,0.009384700621804857,2.027579577104645,0.05890332994779126,1.2298601528008095,1244]
["High","Q14119","Vascular endothelial zinc finger 1 [OS=Homo sapiens]",11,5,10,3,521,56.9,9.52,26.17,"stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","VEZF1","ENSG00000136451","","","",80.3,87.4,93.5,75.8,81.5,81.3,1.0947191953059512,0.1305608538512025,0.15075724524075482,0.8217218069326321,0.3114054420211147,0.506673802111222,3780]
["High","Q14155-1","Isoform 1 of Rho guanine nucleotide exchange factor 7 [OS=Homo sapiens]",24,15,41,12,646,73.1,7.21,77.89,"","","","ARHGEF7","","","","",1901.8,1877.4,1908.4,2139,2017.5,2096.7,0.9095503102411565,-0.1367746545609023,0.006894868687713561,2.1614740005170585,0.05040742950717929,1.2975054485509607,1068]
["High","Q14165","Malectin [OS=Homo sapiens]",41,13,56,13,292,32.2,5.41,127.57,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","MLEC","ENSG00000110917","","Neutrophil degranulation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle","",2785.1,3249,2988.8,2892.1,3176.5,2971.8,0.9980642449449139,-2.7954107072996506E-3,0.9724459732242119,0.01213451769621516,0.9853176951641119,0.006423717714561867,7706]
["High","Q14185","Dedicator of cytokinesis protein 1 [OS=Homo sapiens]",9,13,21,13,1865,215.2,7.56,36.41,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DOCK1","ENSG00000150760","Integrin-mediated cell adhesion; Focal adhesion; Hepatocyte growth factor receptor signaling; Regulation of actin cytoskeleton","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; DCC mediated attractive signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases","Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection",664.2,683.4,635.8,627.6,666.2,651.1,1.0197953622294205,0.028279682083002765,0.511094554252486,0.2914987464575885,0.6778709494824886,0.16885297761112208,5887]
["High","Q14197","Peptidyl-tRNA hydrolase ICT1, mitochondrial [OS=Homo sapiens]",17,3,3,3,206,23.6,10.07,2.99,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL58","ENSG00000167862","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",26.3,27.9,28.8,32.2,24.7,23.3,1.0349127182044888,0.04950909977936687,0.7603773556744078,0.11897082506814673,0.8598155529479763,0.0655947033241614,6905]
["High","Q14247-1","Src substrate cortactin [OS=Homo sapiens]",52,29,112,29,550,61.5,5.4,244.18,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CTTN","ENSG00000085733; ENSG00000288401","Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma","Clathrin-mediated endocytosis; RHO GTPases activate PAKs","Tight junction; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Proteoglycans in cancer",5524,6087.1,5709.3,6743.4,5974.3,6198.9,0.9156190858822412,-0.1271805590135567,0.13236082588946366,0.878240531644266,0.2886797007108749,0.539583753629505,3580]
["High","Q14315","Filamin-C [OS=Homo sapiens]",65,139,716,120,2725,290.8,5.97,1666.9,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","FLNC","ENSG00000128591","Focal adhesion; MAPK signaling pathway; Ebola virus infection in host","Cell-extracellular matrix interactions","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer",22146.3,21175.1,21935.4,16614.4,16484.9,16742.9,1.3092680499656915,0.3887604943549468,7.2016008368385069E-5,4.142570953939821,0.007598662072166901,2.119262869012162,74]
["High","Q14332","Frizzled-2 [OS=Homo sapiens]",2,2,2,1,565,63.5,8.1,3.91,"cell-cell signaling;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","FZD2","ENSG00000180340","MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Asymmetric localization of PCP proteins; Ca2+ pathway; Class B/2 (Secretin family receptors); Disassembly of the destruction complex and recruitment of AXIN to the membrane","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",61,52.3,71.3,81.8,63.2,80.2,0.8197158081705151,-0.2868042744344553,0.16998893906262585,0.7695793366237729,0.3377286606109371,0.47143208234056416,3930]
["High","Q14457","Beclin-1 [OS=Homo sapiens]",18,9,12,9,450,51.9,4.89,21.14,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BECN1","ENSG00000126581","Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; Malignant pleural mesothelioma; Alzheimer's disease","Ub-specific processing proteases; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Autophagy; Mitophagy; Autophagy; Apoptosis; Apelin signaling pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Kaposi sarcoma-associated herpesvirus infection",521.8,446.3,481.5,485.1,478.1,462.6,1.0166923832234533,0.023883234426220038,0.7454376142229973,0.1275886968554022,0.8503107219653999,0.0704223446667756,6845]
["High","Q14527","Helicase-like transcription factor [OS=Homo sapiens]",31,25,42,25,1009,113.9,8.6,87.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HLTF","ENSG00000071794","Retinoblastoma gene in cancer","E3 ubiquitin ligases ubiquitinate target proteins","",1933.2,1989.6,1981.5,2397.4,2379.6,2500.9,0.8112642383105017,-0.30175620114730833,3.9146928178300267E-4,3.4073023109381966,0.014486218730624098,1.8390449615772537,211]
["High","Q14596-1","Next to BRCA1 gene 1 protein [OS=Homo sapiens]",7,4,6,4,966,107.3,5.12,13.95,"other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NBR1","ENSG00000188554","","Pexophagy","Mitophagy",187.8,168.6,174.3,197,178.4,181,0.9538102084831057,-0.06822587113062448,0.3518799744407544,0.4536054482467816,0.5374567371739848,0.26965648873848996,5112]
["High","Q14657","EKC/KEOPS complex subunit LAGE3 [OS=Homo sapiens]",21,2,5,2,143,14.8,8.63,9.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","LAGE3","ENSG00000196976","","tRNA modification in the nucleus and cytosol","",153.1,121.5,169,138.8,92.7,104.1,1.3218116805721096,0.40251664972188667,0.1412493226891926,0.850013626008003,0.29945009816921414,0.5236755402042806,3683]
["High","Q14671-3","Isoform 3 of Pumilio homolog 1 [OS=Homo sapiens]",21,22,57,1,1188,126.6,6.84,117.66,"","","","PUM1","","","","",13.6,20.4,15.4,11.2,18.2,9.1,1.2831168831168829,0.35965259600241367,0.34811579705218754,0.45827626853722553,0.534110462445172,0.2723689147518848,5089]
["High","Q14681","BTB/POZ domain-containing protein KCTD2 [OS=Homo sapiens]",24,3,6,2,263,28.5,5.29,11.77,"cell organization and biogenesis;protein metabolism;other metabolic processes","other cell component","other molecular function","KCTD2","ENSG00000180901","","","",19.2,19.7,21.5,24.8,15.2,19.8,1.0100334448160535,0.014403065126973865,0.9475822154114936,0.02338309887912896,0.9715984160122051,0.012513201892554943,7615]
["High","Q14691","DNA replication complex GINS protein PSF1 [OS=Homo sapiens]",40,6,16,6,196,23,7.39,36.45,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;developmental processes","nucleus;other cell component","","GINS1","ENSG00000101003","","Unwinding of DNA","",594.2,546.7,591.4,612.4,603.1,569.7,0.9703674658301591,-0.043396913835701864,0.4303124560527782,0.3662160824168807,0.6114430676724462,0.21364397451775471,5495]
["High","Q14697-2","Isoform 2 of Neutral alpha-glucosidase AB [OS=Homo sapiens]",61,47,354,1,966,109.4,6.24,762.7,"","","","GANAB","","","","",661.8,719.6,701.3,766.9,703,740.2,0.9423555495226457,-0.08565660537484182,0.1670204844814213,0.7772302608783229,0.33369906418396555,0.47664501126642306,3908]
["High","Q14739","Lamin-B receptor [OS=Homo sapiens]",24,17,59,17,615,70.7,9.36,103.64,"other metabolic processes;developmental processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","LBR","ENSG00000143815","Gastric cancer network 2; ATM signaling in development and disease ; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias","RHOC GTPase cycle; RHOA GTPase cycle; RHOD GTPase cycle; Regulation of MECP2 expression and activity; CDC42 GTPase cycle; RAC1 GTPase cycle; Cholesterol biosynthesis; Initiation of Nuclear Envelope (NE) Reformation; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","Steroid biosynthesis; Metabolic pathways",3128.2,3414.3,3230.7,3558.2,3516.3,3486.3,0.925422316491175,-0.11181620507974001,0.03825314545624587,1.4173328481410676,0.13048517244314886,0.8844388361569752,2289]
["High","Q14790-4","Isoform 4 of Caspase-8 [OS=Homo sapiens]",20,6,8,6,496,57.7,5.43,17.84,"","","","CASP8","","","","",251,269.8,251.3,324.8,318.5,326.5,0.7961435347494328,-0.32889954074734346,5.910913009738413E-4,3.2283454320685685,0.017221048052252812,1.763940421438722,268]
["High","Q14894","Ketimine reductase mu-crystallin [OS=Homo sapiens]",26,6,9,6,314,33.8,5.14,14.17,"other metabolic processes;transport;other biological processes","cytosol;other cytoplasmic organelle;other cell component","other molecular function","CRYM","ENSG00000103316","","Lysine catabolism","",351.6,339.9,354.8,304.7,341.1,345.9,1.0550569728748613,0.0773209062924078,0.25687772589306607,0.5902735521802036,0.44003977265753835,0.356508068365925,4558]
["High","Q14974","Importin subunit beta-1 [OS=Homo sapiens]",54,37,300,37,876,97.1,4.78,636.72,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","KPNB1","ENSG00000108424","Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome","Neutrophil degranulation; Assembly of the ORC complex at the origin of replication; Apoptosis induced DNA fragmentation; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Regulation of cholesterol biosynthesis by SREBP (SREBF); Initiation of Nuclear Envelope (NE) Reformation; Postmitotic nuclear pore complex (NPC) reformation; Inhibition of nitric oxide production","Nucleocytoplasmic transport; Chemical carcinogenesis",10809.3,10616.4,10544.7,10389.1,10714.7,10753.1,1.0035628074294736,5.130909806183412E-3,0.8002235087037632,0.09678869420876995,0.8857591658575252,0.052684344881605415,7054]
["High","Q14BN4","Sarcolemmal membrane-associated protein [OS=Homo sapiens]",22,18,27,18,828,95.1,5.47,58.18,"other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","SLMAP","ENSG00000163681","","","",961.3,935.5,998.8,1016.9,995.4,1015,0.9564958874244375,-0.06416932935321941,0.08886360678548189,1.0512760636447407,0.22303022879493492,0.6516362700948086,3111]
["High","Q15006","ER membrane protein complex subunit 2 [OS=Homo sapiens]",34,9,37,9,297,34.8,6.57,77.06,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC2","ENSG00000104412","","","",904.7,888.2,914.9,829.8,855.8,843.3,1.0707422199375223,0.09861119457816629,5.2720586392459075E-3,2.278019767883073,0.04426261704863661,1.353962911778373,930]
["High","Q15007","Pre-mRNA-splicing regulator WTAP [OS=Homo sapiens]",32,10,23,10,396,44.2,5.19,66.49,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","WTAP","ENSG00000146457","","Processing of Capped Intron-Containing Pre-mRNA","",845.7,824.3,868.1,826.8,816.9,835.4,1.0237989592997458,0.033932444931032285,0.22525833701441544,0.6473191264205873,0.40581843456588734,0.3916682287457511,4334]
["High","Q15022","Polycomb protein suz12 [OS=Homo sapiens]",13,7,11,7,739,83,8.81,21.89,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","SUZ12","ENSG00000178691","Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma","HCMV Early Events; Defective pyroptosis; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines","",338.8,388.7,355.2,382.3,412.4,392.3,0.9121314237573716,-0.13268638591088017,0.11249674990751077,0.9488600243759344,0.2590311481208623,0.5866480094953853,3391]
["Medium","Q15035","Translocating chain-associated membrane protein 2 [OS=Homo sapiens]",2,1,1,1,370,43.3,9.22,1.96,"cell organization and biogenesis;other metabolic processes;transport","other membranes;ER/Golgi","","TRAM2","ENSG00000065308","","","",53.4,51.4,61.5,54.5,56,60.8,0.9708114419147694,-0.042736982796729904,0.6696049232972445,0.17418136183533767,0.7955379246964219,0.0993391119397264,6572]
["High","Q15047","Histone-lysine N-methyltransferase SETDB1 [OS=Homo sapiens]",16,19,52,19,1291,143.1,6.02,98.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETDB1","ENSG00000143379","Histone modifications; Malignant pleural mesothelioma","PKMTs methylate histone lysines","Lysine degradation; Metabolic pathways; Signaling pathways regulating pluripotency of stem cells",1966.3,1999.3,1960,2292.7,2356.4,2292.2,0.8536729431086395,-0.2282446406497875,1.6033645041681294E-4,3.79496773519201,0.010346338883094837,1.9852133008498252,121]
["High","Q15054","DNA polymerase delta subunit 3 [OS=Homo sapiens]",23,11,24,11,466,51.4,9.35,42.02,"DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","POLD3","ENSG00000077514","Homologous recombination; Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Dual Incision in GG-NER; Termination of translesion DNA synthesis; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)","DNA replication; Base excision repair; Nucleotide excision repair; Mismatch repair; Homologous recombination",979.8,956.7,963.7,1108.4,1118.9,1090.8,0.8740544287393386,-0.19420497348257987,1.9911452009059347E-4,3.7008970686250824,0.011348074254506232,1.9450778311228538,137]
["High","Q15070-1","Mitochondrial inner membrane protein OXA1L [OS=Homo sapiens]",11,5,7,5,435,48.5,9.45,14.77,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;other cell component","translation activity;other molecular function","OXA1L","ENSG00000155463","","Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination","Protein export",502.8,536.6,522.8,611.4,585.6,572.7,0.8827484884443692,-0.17992564926859225,0.010001138945406331,1.999950539046097,0.06110242009838234,1.213941588209843,1278]
["Medium","Q15121","Astrocytic phosphoprotein PEA-15 [OS=Homo sapiens]",8,1,1,1,130,15,5.02,2.31,"transport;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus","","PEA15","ENSG00000162734","Apoptosis modulation and signaling","RAF/MAP kinase cascade; RAF-independent MAPK1/3 activation","",103.3,100.2,113.4,104.5,87.7,95.5,1.1014946124435177,0.13946243864294677,0.1961113293651663,0.7074973163849954,0.3706698764665259,0.431012706702946,4131]
["High","Q15149-3","Isoform 3 of Plectin [OS=Homo sapiens]",41,185,463,1,4570,517.7,5.74,980.82,"","","","PLEC","","","","",11.5,11.2,7.1,14,14.6,13.8,0.7028301886792451,-0.508751934101038,0.04334576497979075,1.3630533280783086,0.14090080473031066,0.8510865264865605,2402]
["High","Q15172-1","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [OS=Homo sapiens]",5,2,2,2,486,56.2,6.71,3.11,"protein metabolism;other metabolic processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP2R5A","ENSG00000066027; ENSGGOG00000014986; ENSNLEG00000002787; ENSPPAG00000015631; ENSPPYG00000000237; ENSPTRG00000001958","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; Glycogen metabolism","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Separation of Sister Chromatids; RAF activation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; Dopaminergic synapse; Human papillomavirus infection",64.7,54.3,59.6,64.7,81.3,66.5,0.8404705882352942,-0.25073076079120343,0.13545771803007603,0.8681962449506347,0.29257368253909644,0.533764741922549,3615]
["High","Q15233","Non-POU domain-containing octamer-binding protein [OS=Homo sapiens]",58,27,490,25,471,54.2,8.95,715.13,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","NONO","ENSG00000147140","mRNA processing","","",12396.1,12553.4,12425,13086.9,13434.7,13453.3,0.9349491806108333,-0.09704014579433304,2.5240309753988203E-3,2.5979053196488873,0.03108459598724604,1.5074547728719845,634]
["High","Q15283-1","ras GTPase-activating protein 2 [OS=Homo sapiens]",8,6,6,6,850,96.6,7.2,14.19,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;other molecular function","RASA2","ENSG00000155903","MAPK signaling pathway; Ebola virus infection in host; Ras signaling; Modulators of TCR signaling and T cell activation","Regulation of RAS by GAPs","MAPK signaling pathway; Ras signaling pathway; Viral carcinogenesis",380.7,368.5,343.1,358,383.1,339.9,1.0104532839963,0.01500262354365905,0.8327965920714878,0.07946106069201574,0.9046293532128793,0.043529324470316585,7188]
["High","Q15365","Poly(RC)-binding protein 1 [OS=Homo sapiens]",84,18,347,12,356,37.5,7.09,948.55,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCBP1","ENSG00000169564","Ferroptosis","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Spliceosome; Ferroptosis",9484.6,9505.9,9590.3,10058.1,9812.8,10007,0.9565866409620487,-0.06403245111946805,0.006037667699856989,2.2191307932820825,0.047426669416985284,1.3239773730207602,994]
["High","Q15366-1","Poly(rC)-binding protein 2 [OS=Homo sapiens]",65,16,384,1,365,38.6,6.79,990.65,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101348589; Pcbp2; PCBP2","ENSBIXG00000004442; ENSCAFG00000006821; ENSG00000197111; ENSRNOG00000036852","mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation","mRNA Splicing - Major Pathway; Negative regulators of DDX58/IFIH1 signaling; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway","Ferroptosis",327.3,357.9,333.9,319.2,315.2,316.4,1.071834244846445,0.10008181565792232,0.07205231140646602,1.1423520826505162,0.19453127505590828,0.7110105666143739,2892]
["High","Q15390","Mitochondrial fission regulator 1 [OS=Homo sapiens]",9,3,6,3,333,37,9.01,10.91,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;mitochondrion","","MTFR1","ENSG00000066855","","","",259.3,264.2,264.8,299.5,283.8,282.1,0.9109082505199908,-0.134622346223122,0.011452984852147267,1.9410813136837353,0.06556078132372864,1.1833558793455599,1364]
["High","Q15427","Splicing factor 3b subunit 4 [OS=Homo sapiens]",27,8,35,8,424,44.4,8.56,70.93,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","SF3B4","ENSG00000143368","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",952.5,1029.4,1046.3,1097.1,1064.2,1072.6,0.936392590989208,-0.09481457541545285,0.0878727248207151,1.056145906473974,0.22132588238714307,0.6549677956496113,3100]
["High","Q15438-1","Cytohesin-1 [OS=Homo sapiens]",14,3,3,2,398,46.4,5.54,9.12,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CYTH1","ENSCATG00000038229; ENSG00000108669; ENSMFAG00000037544; ENSMMUG00000013313; ENSPANG00000019854; ENSPTRG00000009717","","Intra-Golgi traffic","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection",22.9,17.3,26.2,19.7,23.9,17,1.0957095709570959,0.13186544787397406,0.5875777226130854,0.23093467838486756,0.7352254580389376,0.13357946340865617,6240]
["High","Q15542","Transcription initiation factor TFIID subunit 5 [OS=Homo sapiens]",24,11,28,11,800,86.8,5.64,63.38,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","TAF5","ENSG00000148835","Eukaryotic transcription initiation","Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors",589.2,607.9,590.1,631.1,647,632,0.9356578189623579,-0.09594707912167813,0.006818100895720267,2.166336576276629,0.050317326837224806,1.2982824393171604,1058]
["High","Q15560","transcription elongation factor A protein 2 [OS=Homo sapiens]",25,6,17,4,299,33.6,9.13,31.02,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","TCEA2","ENSG00000171703","","","",138.6,132.1,136,127.4,124,131.7,1.0616027146959017,0.08624396503825281,0.05447015270417112,1.263841407203719,0.16097765038386377,0.793234415823592,2642]
["Medium","Q15573-1","TATA box-binding protein-associated factor RNA polymerase I subunit A [OS=Homo sapiens]",2,1,1,1,450,52.6,9.1,2.59,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus","nucleic acid binding activity","TAF1A","ENSG00000143498","","RNA Polymerase I Transcription Initiation; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; SIRT1 negatively regulates rRNA expression; RNA Polymerase I Transcription Termination","",29.3,25.5,27.5,30,18.3,29,1.0646830530401035,0.09042401649677825,0.6912710523280083,0.16035162925590737,0.8110359694330713,0.09095988440796586,6655]
["High","Q15637-5","Isoform 5 of Splicing factor 1 [OS=Homo sapiens]",25,13,62,13,673,71.7,9.58,126.09,"","","","SF1","","","","",2772,2658.9,2795.3,3328.5,2928.4,3061.9,0.8827531441816545,-0.1799180403160213,0.04344605626796183,1.3620496396709032,0.1410506475427218,0.8506249157221183,2405]
["High","Q15678","Tyrosine-protein phosphatase non-receptor type 14 [OS=Homo sapiens]",9,7,12,7,1187,135.2,8.31,17.6,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN14","ENSG00000152104","VEGFA-VEGFR2 signaling pathway","Interleukin-37 signaling","",254.5,233.3,223,218.8,241.1,215,1.0531930656393538,0.07476992763538069,0.3870681326924676,0.41221258266067234,0.5710937226120157,0.24329261351750028,5292]
["High","Q15723-1","Isoform 1 of ETS-related transcription factor Elf-2 [OS=Homo sapiens]",3,1,1,1,581,62.7,6.7,2.61,"","","","ELF2","","","","",42.8,29.8,28.4,38.2,33.8,27.8,1.0120240480961924,0.01724357230189657,0.9453812861156945,0.02439299883565294,0.9706163158437006,0.012952412566034747,7605]
["High","Q15751","Probable E3 ubiquitin-protein ligase HERC1 [OS=Homo sapiens]",3,10,12,10,4861,531.9,6.04,18.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","HERC1","ENSG00000103657","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",282.4,284.3,273.8,277.6,274.2,275.8,1.0155872402126633,0.02231417426352052,0.27177648297870255,0.5657881258023851,0.4557626243766558,0.34126129278558176,4656]
["High","Q15800","Methylsterol monooxygenase 1 [OS=Homo sapiens]",9,2,7,2,293,35.2,7.23,14.11,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","MSMO1","ENSG00000052802","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Cholesterol biosynthesis","Steroid biosynthesis; Metabolic pathways",327.3,373.5,308.9,369.6,429,424.7,0.825390337611379,-0.2768515452772579,0.058409227317214006,1.2335185389082226,0.16822546916001732,0.7741082518300727,2711]
["High","Q15811-7","Isoform 7 of Intersectin-1 [OS=Homo sapiens]",33,30,62,29,1215,137,7.33,118.38,"","","","ITSN1","","","","",2096,2053.2,2134.9,2437.7,2291,2309.8,0.8928180720323935,-0.16356186502353498,8.298090806986581E-3,2.081021816945295,0.05514169618804359,1.2585198788944147,1175]
["High","Q15942","Zyxin [OS=Homo sapiens]",35,12,44,12,572,61.2,6.67,85.33,"cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","ZYX","ENSG00000159840; ENSG00000285443","Integrin-mediated cell adhesion; Focal adhesion","","Focal adhesion",734.2,745.7,821.9,1042.3,771.7,700.1,0.9155562626784934,-0.12727954977881184,0.5472879588761779,0.26178410685687103,0.7055017967484227,0.15150187586153738,6057]
["High","Q16143","Beta-synuclein [OS=Homo sapiens]",30,4,13,1,134,14.3,4.41,31.63,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","cytosol;other cell component","enzyme regulator activity;other molecular function","SNCB","ENSG00000074317","","MTF1 activates gene expression","",180.6,186.1,185.3,208.8,187.4,185.1,0.9495957337003268,-0.07461464156635467,0.275491334998594,0.5598920564182828,0.4598196544824759,0.33741246923278156,4678]
["High","Q16513","Serine/threonine-protein kinase N2 [OS=Homo sapiens]",18,14,30,10,984,112,6.3,68.68,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","PKN2","ENSG00000065243","PI3K-Akt signaling pathway","RAC1 GTPase cycle; RHO GTPases activate PKNs; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle","PI3K-Akt signaling pathway; NOD-like receptor signaling pathway; Yersinia infection",432.9,452.1,435.6,449.1,465.6,483.5,0.9445000715205264,-0.08237718902829133,0.08971947506539965,1.0471132760706483,0.22381139338998096,0.6501178089584614,3130]
["High","Q16539-2","Isoform CSBP1 of Mitogen-activated protein kinase 14 [OS=Homo sapiens]",28,8,23,1,360,41.5,5.88,39.57,"","","","MAPK14","","","","",23.2,27.7,18.4,17.4,19.8,21.7,1.1765704584040744,0.23458771830675262,0.3064441397549891,0.5136486794070119,0.4933434728261762,0.3068506133506402,4850]
["High","Q16566","calcium/calmodulin-dependent protein kinase type IV [OS=Homo sapiens]",7,3,5,3,473,51.9,5.82,11.99,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","CAMK4","ENSG00000152495","Energy metabolism; Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway; Common pathways underlying drug addiction; Mitochondrial gene expression; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; CAMKK2 pathway; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells","Transcriptional activation of mitochondrial biogenesis; Regulation of MECP2 expression and activity; Negative regulation of NMDA receptor-mediated neuronal transmission; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; Loss of phosphorylation of MECP2 at T308","Calcium signaling pathway; cAMP signaling pathway; Longevity regulating pathway; Apelin signaling pathway; Osteoclast differentiation; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Oxytocin signaling pathway; Aldosterone synthesis and secretion; Amphetamine addiction; Alcoholism; Glioma",171.2,176.6,201.8,204.2,204.8,203.2,0.8977458346945439,-0.15562104070889193,0.09161059323139845,1.0380543045423956,0.2260017415326253,0.6458882142371339,3165]
["High","Q16629","serine/arginine-rich splicing factor 7 [OS=Homo sapiens]",35,12,87,11,238,27.4,11.82,155.06,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","other molecular function","SRSF7","ENSG00000115875","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection",3693.3,3470.2,3530.3,3881,3677.7,3889.8,0.9340787002664105,-0.09838398638627048,0.05899407922893534,1.2291915728871976,0.16928547248053186,0.7713803100083197,2721]
["High","Q16658","Fascin [OS=Homo sapiens]",68,33,275,33,493,54.5,7.24,687.19,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","FSCN1","ENSG00000075618","VEGFA-VEGFR2 signaling pathway","Interleukin-4 and Interleukin-13 signaling","MicroRNAs in cancer",8215.1,8942.9,8514,7902.8,8825.2,8387.5,1.022157631741355,0.03161769822788772,0.6143090776184628,0.21161306708239172,0.7564304176068376,0.12123101561071786,6341]
["High","Q16698","2,4-dienoyl-CoA reductase, mitochondrial [OS=Homo sapiens]",26,6,11,6,335,36,9.28,28.23,"other metabolic processes;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","DECR1","ENSG00000104325","Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway","mitochondrial fatty acid beta-oxidation of unsaturated fatty acids","",248.2,237.6,236.9,242.8,245.2,245.4,0.9854104172347967,-0.021203371752039235,0.3953852677625274,0.4029795167336201,0.5785547546270265,0.2376555329834773,5336]
["High","Q16774-1","guanylate kinase [OS=Homo sapiens]",21,4,11,4,197,21.7,6.55,26.05,"other metabolic processes;transport","cytosol;other cell component","kinase activity;other molecular function","GUK1","ENSG00000143774","","Interconversion of nucleotide di- and triphosphates; Abacavir metabolism","Purine metabolism; Metabolic pathways",839.4,705.8,793.3,663.7,643.8,613.6,1.2172713549528915,0.2836508104566117,0.02914242616761319,1.5354742951416909,0.10997779773645422,0.95869498114879,2069]
["High","Q16799-1","Reticulon-1 [OS=Homo sapiens]",4,2,2,1,776,83.6,4.69,6.67,"developmental processes;other biological processes","other membranes;ER/Golgi","","RTN1","ENSG00000139970","","","",14.9,22.3,18.2,19.2,11,18.6,1.1352459016393444,0.18300482848630217,0.5526164899992911,0.2575761599391449,0.7093259171320838,0.1491541717434327,6083]
["Medium","Q16854","Deoxyguanosine kinase, mitochondrial [OS=Homo sapiens]",3,1,1,1,277,32,8.66,2.25,"protein metabolism;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","DGUOK","ENSG00000114956","","Purine salvage","Purine metabolism; Metabolic pathways",75.3,104.5,73.7,80.7,111.7,94.4,0.8838912133891212,-0.17805927681120204,0.4553036614569217,0.34169885717227805,0.6329020809427888,0.19866347638978493,5617]
["High","Q1KMD3","heterogeneous nuclear ribonucleoprotein U-like protein 2 [OS=Homo sapiens]",55,37,154,37,747,85.1,4.91,356.2,"","nucleus","","HNRNPUL2","ENSG00000214753","","","",5869,5686.9,5948.3,5752.4,5765.3,6086.7,0.9943082411215377,-0.008234930221640511,0.8153825113546083,0.08863860770314298,0.8937956828101616,0.04876174738907682,7123]
["High","Q2M1P5","Kinesin-like protein KIF7 [OS=Homo sapiens]",16,16,22,15,1343,150.5,6.79,36.2,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF7","ENSG00000166813","Hedgehog signaling pathway; Hedgehog signaling pathway; Ciliopathies","Hedgehog 'on' state; Hedgehog 'off' state","Hedgehog signaling pathway; Pathways in cancer; Basal cell carcinoma",733.1,656.2,678.7,743.2,633,700.9,0.9956188917240384,-6.334489379580162E-3,0.9423099685347636,0.025806214531051676,0.9703978151304978,0.013050189962832035,7582]
["High","Q2NKX8","Dna excision repair protein ercc-6-like [OS=Homo sapiens]",28,28,42,28,1250,141,5.31,93.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","ERCC6L","ENSG00000186871","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",1679.7,1906.2,1825.3,1774.6,1726.6,1788.9,1.0228918167898526,0.032653570661024686,0.5893956708677063,0.2295930583828893,0.7366738271386346,0.13272475967027567,6247]
["Low","Q2TAK8-1","PWWP domain-containing protein MUM1 [OS=Homo sapiens]",2,1,1,1,710,78.6,8.54,0,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","other molecular function","PWWP3A","ENSG00000160953","IL-18 signaling pathway","","",27.7,23.8,29,55.8,49.9,66.3,0.46802325581395343,-1.0953478765874811,0.003773567326413296,2.4232478971025713,0.03767776686014707,1.423914845503784,782]
["High","Q2TAZ0-1","Autophagy-related protein 2 homolog A [OS=Homo sapiens]",9,11,13,11,1938,212.7,5.88,25.74,"cell organization and biogenesis;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ATG2A","ENSG00000110046","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease","","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",266.8,274.1,268.3,260.8,234.5,235.3,1.1075828086504245,0.14741456619626486,0.04248780736383366,1.3717356806393266,0.13944716263001816,0.8555903180179575,2379]
["High","Q32P28-1","Prolyl 3-hydroxylase 1 [OS=Homo sapiens]",42,25,107,23,736,83.3,5.14,239.1,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","P3H1","ENSG00000117385","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",4221.8,4206,4271.9,4172.7,4011.6,4092.9,{"$f":"AVERAGE(T3522:V3522)/AVERAGE(W3522:Y3522)","v":1.0344133841592544},{"$f":"LOG(Z3522,2)","v":0.04881284725158424},{"$f":"TTEST(T3522:V3522,W3522:Y3522,2,2)","v":0.049571029743315995},{"$f":"-LOG10(AB3522)","v":1.3047720593640664},{"$f":"AB3522*7808/AF3522","v":0.15256231779101745},{"$f":"-LOG10(AD3522)","v":0.8165527219271618},2537]
["Low","Q3C1V8","Brain-specific homeobox protein homolog [OS=Homo sapiens]",6,1,1,1,233,25.9,7.5,0,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BSX","ENSG00000188909","","","",150.4,149.9,139.4,150.3,165.4,158.8,0.926659641728135,-0.1098885546958244,0.10946372877357356,0.960729762129878,0.254827905266566,0.5937530157413096,3354]
["High","Q3KR37","GRAM domain-containing protein 1B [OS=Homo sapiens]",3,2,2,2,738,85.3,6.21,2.16,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","GRAMD1B","ENSG00000023171","Ectoderm differentiation","","",27,34.5,27,32.9,32.7,36.3,0.8684985279685968,-0.20340469119545374,0.18082493247681417,0.7427416884039556,0.35165157478928144,0.4538874333600199,4015]
["High","Q3T8J9-1","GON-4-like protein [OS=Homo sapiens]",7,9,10,8,2241,248.5,5.01,14.2,"developmental processes;other biological processes","nucleus","other molecular function","GON4L","ENSG00000116580","","","",248.1,244.2,267.6,248.1,226.2,252,1.0462618752581578,0.06524399771356454,0.3586970713420889,0.44527216919847584,0.5440378269306585,0.26437090277218955,5148]
["High","Q3YEC7-1","Rab-like protein 6 [OS=Homo sapiens]",24,15,40,15,729,79.5,5.22,51.27,"","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RABL6","ENSG00000196642","","","",1219.3,1222.5,1192,1255.3,1166.6,1204.4,1.0020682238093925,2.9807348812564494E-3,0.9318369929727943,0.030660052500106505,0.9636798994876262,0.016067199470659353,7550]
["High","Q49A26-5","Isoform 5 of Putative oxidoreductase GLYR1 [OS=Homo sapiens]",39,11,34,2,472,51.5,8.27,60.96,"","","","","","","","",23.9,34.4,22.4,40.3,30.9,31.8,0.7834951456310679,-0.3520037587928005,0.19777783378879576,0.7038223841374796,0.3725571353975675,0.4288071143651365,4145]
["High","Q4G0N4","NAD kinase 2, mitochondrial [OS=Homo sapiens]",6,2,4,2,442,49.4,8.18,10.44,"other metabolic processes","mitochondrion","kinase activity;other molecular function","NADK2","ENSG00000152620","","Nicotinate metabolism","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors",142.3,179.7,132.2,154.9,192.2,188.5,0.8480209111277073,-0.23782825461742269,0.22030333253685636,0.6569789332104639,0.3993797122005513,0.39861400031442856,4307]
["High","Q4G148-1","Glucoside xylosyltransferase 1 [OS=Homo sapiens]",13,5,12,5,440,50.5,8.65,15.35,"protein metabolism;other metabolic processes","other membranes","other molecular function","GXYLT1","ENSG00000151233","","","Other types of O-glycan biosynthesis",477,515.5,494.7,491,478,484.5,1.0231854145166839,0.03306760389588198,0.39289914146300337,0.4057189201784904,0.5765375862700864,0.2391723744445775,5321]
["High","Q4V328","GRIP1-associated protein 1 [OS=Homo sapiens]",57,35,105,35,841,95.9,5.11,236.5,"","","","","","","","",3693.9,3378.4,3654.3,3603.2,3139.5,3251.5,1.0732825038522342,0.10202986478327014,0.22734194627770996,0.6433204263240695,0.40750365393396676,0.3898684927491715,4356]
["High","Q4ZIN3-1","Membralin [OS=Homo sapiens]",4,3,5,3,620,67.8,5.3,7.84,"stress response;other biological processes","other membranes;ER/Golgi","","TMEM259","ENSG00000182087","","","",281.9,279.4,294.2,268,235.4,243.5,1.1454009907618157,0.1958527564947469,0.028639909117346887,1.5430283645030567,0.10887069639155039,0.9630889991056808,2054]
["High","Q53EP0","Fibronectin type III domain-containing protein 3B [OS=Homo sapiens]",6,5,8,5,1204,132.8,5.95,11.71,"","other membranes","","FNDC3B","ENSG00000075420","","","",128.7,123.2,130.1,131.4,125.6,112,{"$f":"AVERAGE(T3586:V3586)/AVERAGE(W3586:Y3586)","v":1.035230352303523},{"$f":"LOG(Z3586,2)","v":0.04995182197535244},{"$f":"TTEST(T3586:V3586,W3586:Y3586,2,2)","v":0.5181616342562473},{"$f":"-LOG10(AB3586)","v":0.2855347462086194},{"$f":"AB3586*7808/AF3586","v":0.6830670336438931},{"$f":"-LOG10(AD3586)","v":0.16553667419092755},5923]
["High","Q53G59-1","Kelch-like protein 12 [OS=Homo sapiens]",20,8,12,7,568,63.2,5.44,18.03,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","KLHL12","ENSCANG00000030198; ENSCATG00000031800; ENSG00000117153; ENSGGOG00000009159; ENSMLEG00000023751; ENSMMUG00000017849; ENSMNEG00000042480; ENSPPAG00000041960; ENSPTRG00000001861; ENSRBIG00000033303; ENSRROG00000044766","","Degradation of DVL","",373.1,371.3,376.2,354.1,358.2,353,1.0519102600206516,0.07301163148806267,9.8662713723611365E-4,3.005846943414912,0.021105711472711168,1.6756000032127512,365]
["Medium","Q53HI1","protein unc-50 homolog [OS=Homo sapiens]",2,1,2,1,259,30.4,9.47,4.67,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity","UNC50","ENSG00000115446","","","",150.1,162.7,155.6,227.7,240.7,231.9,0.6688562044837927,-0.5802320116385838,1.2748337665277102E-4,3.894546441886064,0.009479906713379392,2.0231959362973666,105]
["High","Q53HV7-1","single-strand selective monofunctional uracil DNA glycosylase [OS=Homo sapiens]",8,2,3,2,270,29.8,6.62,7.09,"DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","nucleic acid binding activity;other molecular function","SMUG1","ENSG00000123415; ENSPPAG00000033677","Fluoropyrimidine activity; Base excision repair; DNA repair pathways, full network","Displacement of DNA glycosylase by APEX1; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine","Base excision repair",127.1,108.5,117.1,114.9,121.9,127.4,0.9684239428885226,-0.04628934655058675,0.5858598417687854,0.23220627003471275,0.7338991889187673,0.13436359226807593,6233]
["High","Q587I9","vesicle transport protein SFT2C [OS=Homo sapiens]",27,4,12,4,215,21.8,9.89,39.1,"transport","other membranes","","SFT2D3","ENSG00000173349","","","",324.5,332.8,336.8,328.7,363.7,335,0.9675880864317693,-0.047535088851477704,0.38399379632106617,0.41567579189625004,0.5679529383737232,0.24568764923857309,5279]
["High","Q587J7-1","Putative ATP-dependent RNA helicase TDRD12 [OS=Homo sapiens]",15,15,33,15,1177,132.5,6.74,54.58,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","other cell component","nucleic acid binding activity;other molecular function","TDRD12","ENSG00000173809","","PIWI-interacting RNA (piRNA) biogenesis","",1024,1086,1048.2,1250.8,1449.6,1321.7,0.7852117053280626,-0.3488464153424779,9.11562580467855E-3,2.0402135108609842,0.05800717708470263,1.236518268929353,1227]
["High","Q5BJF2","sigma intracellular receptor 2 [OS=Homo sapiens]",10,2,10,2,176,20.8,9.38,9.4,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","","TMEM97","ENSG00000109084","","","",331.4,384.3,329.5,359.7,398.9,376.4,0.9208810572687226,-0.1189132677456187,0.23169449477238088,0.6350842852362696,0.4120889784015376,0.3850090008197556,4390]
["High","Q5EBL4-1","RILP-like protein 1 [OS=Homo sapiens]",42,12,26,12,403,47.1,5.21,59.7,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RILPL1","ENSG00000188026; ENSGGOG00000014925","","","",1042.5,952.2,993.7,1123.2,1098.7,1099.6,0.8997139846454915,-0.15246164734923906,0.015259703778307333,1.8164538968329857,0.07589029751657558,1.119813744583584,1570]
["High","Q5EBM0-1","UMP-CMP kinase 2, mitochondrial [OS=Homo sapiens]",3,1,1,1,449,49.4,7.01,3.06,"other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","kinase activity;other molecular function","CMPK2","ENSG00000134326","Pyrimidine metabolism","","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",75.3,88.9,92.1,82.1,101.3,92.4,0.9292965917331399,-0.10578897822240291,0.43891932510104653,0.35761529725942,0.6196134677976806,0.20787915106995017,5531]
["High","Q5HYJ3-1","Protein FAM76B [OS=Homo sapiens]",17,6,9,4,339,38.7,9.25,11.8,"","nucleus","","FAM76B","ENSG00000077458","","","",210.1,238.4,238.5,202,208,199.1,1.1278936135281563,0.1736309946217866,0.05710969505167009,1.243290158828934,0.16582837447506138,0.7803411563936002,2689]
["High","Q5JPI3","Uncharacterized protein C3orf38 [OS=Homo sapiens]",19,5,10,5,329,37.5,6.47,16.16,"other biological processes","nucleus","","C3orf38","ENSG00000179021","","","",313.8,344.4,341.3,344,333.1,348.9,0.9741715399610137,-0.03775225886242637,0.4588536333327763,0.3383258250795521,0.6361379916658945,0.19644866655497245,5632]
["High","Q5JRA6-1","Transport and Golgi organization protein 1 homolog [OS=Homo sapiens]",41,65,167,64,1907,213.6,4.84,369.78,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MIA3","ENSG00000154305","Type I collagen synthesis in the context of osteogenesis imperfecta","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER","",7604.2,7241.2,7655.3,6796.2,6426.3,6964.8,1.1145968009590188,0.15652191780805466,0.019944758384873182,1.7001712204597774,0.08783343117263949,1.0563401514020596,1773]
["High","Q5JTV8-3","Isoform 3 of Torsin-1A-interacting protein 1 [OS=Homo sapiens]",28,14,38,1,584,66.3,8.18,78.04,"","","","TOR1AIP1","","","","",17.1,18.5,15.7,21.6,18.4,15.8,0.9193548387096774,-0.1213062962221336,0.46562103652852144,0.33196740670466474,0.6420997974593246,0.19239746707511352,5662]
["High","Q5M775-1","Cytospin-B [OS=Homo sapiens]",16,16,23,16,1068,118.5,6.7,44.06,"cell organization and biogenesis","other membranes;cytosol;cytoskeleton;nucleus;other cell component","","SPECC1","ENSG00000128487","","","",1147,1072.2,1217.1,1202,962.1,1054.1,1.067770803554782,0.09460200651944964,0.4224983206498879,0.37417501294845773,0.6034144663680858,0.21938428218137943,5467]
["High","Q5PRF9","protein Smaug homolog 2 [OS=Homo sapiens]",30,11,26,11,694,75.4,6.83,54.45,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMD4B","ENSG00000179134","","","",694.9,705.7,656.4,679.6,704,697,0.9886571181389984,-0.016457836522716845,0.6607947515505141,0.17993341511518984,0.7901202787299256,0.10230679173162838,6530]
["High","Q5RI15-1","Cytochrome c oxidase protein 20 homolog [OS=Homo sapiens]",22,2,3,2,118,13.3,8.76,10.54,"cell organization and biogenesis","other membranes;mitochondrion","","COX20; FAM36A","ENSG00000203667","Mitochondrial complex IV assembly","TP53 Regulates Metabolic Genes; Respiratory electron transport; Cytoprotection by HMOX1","Thermogenesis",280.1,283.5,297.9,293,330.5,322.9,0.9102916314454778,-0.13559927722747767,0.08941430709303515,1.0485929846221644,0.22362168795080667,0.6504860786899277,3122]
["Medium","Q5SNT2-1","Transmembrane protein 201 [OS=Homo sapiens]",2,1,1,1,666,72.2,9.22,1.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TMEM201","ENSG00000188807; ENSPTRG00000049393","","","",45.6,46.8,48,54,45.2,43.4,0.9845722300140254,-0.022431046139327174,0.8373112314341151,0.07711308326065959,0.9070097246167551,0.04238805657303075,7208]
["High","Q5SRD1","Putative mitochondrial import inner membrane translocase subunit Tim23B [OS=Homo sapiens]",14,2,8,2,257,28,9.39,24.02,"","","","","","","","",325,426.1,347.1,342.2,461.5,403.5,0.9097084161696487,-0.13652389458241906,0.47496979832468533,0.32333400477079305,0.6495996120720167,0.18735424311884052,5709]
["High","Q5SYC1-1","Clavesin-2 [OS=Homo sapiens]",6,1,1,1,327,38,6.2,3.32,"cell organization and biogenesis","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLVS2; LOC101343624","ENSAMEG00000028872; ENSCAFG00000001006; ENSCATG00000031634; ENSCSAG00000016282; ENSDLEG00000011174; ENSECAG00000006114; ENSFCAG00000010835; ENSG00000146352; ENSGGOG00000027351; ENSLAFG00000007550; ENSMFAG00000003285; ENSMLEG00000033559; ENSMMUG00000018176; ENSMNEG00000035011; ENSNLEG00000013863; ENSOARG00000008112; ENSPANG00000003404; ENSPCOG00000011744; ENSPPAG00000036654; ENSPPYG00000016981; ENSPTRG00000018566; ENSRBIG00000041651; ENSRROG00000010239; ENSSSUG00005005271; ENSSTOG00000001439; ENSTTRG00000010743; ENSUAMG00000008720; ENSUMAG00000001385; ENSVVUG00000000265","","Lysosome Vesicle Biogenesis; Lysosome Vesicle Biogenesis","",18.5,28,22.7,25.6,18.6,23.6,1.0206489675516222,0.02948676450038037,0.8988734975273815,0.046301424163937004,0.9427003718863393,0.025626321593496516,7445]
["High","Q5T0D9","Tumor protein p63-regulated gene 1-like protein [OS=Homo sapiens]",21,2,5,2,272,30.2,7.34,18.33,"other biological processes","other membranes;ER/Golgi;other cell component","","TPRG1L","ENSG00000158109","","","",91.2,78.9,88.6,87.6,82.9,84,1.0165029469548137,0.023614397721683826,0.7441595241160635,0.12833395556024332,0.8495975382801906,0.07078675463463782,6839]
["High","Q5T160","probable arginine--tRNA ligase, mitochondrial [OS=Homo sapiens]",22,11,12,11,578,65.5,8.21,25.19,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","RARS2","ENSG00000146282","","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",522.5,494.2,489.7,425.8,484.1,475.5,1.0873393965641693,0.12080232611895704,0.12543812182915054,0.9015704572532472,0.27824456114829754,0.5555733160727429,3520]
["High","Q5T2E6-1","UPF0668 protein C10orf76 [OS=Homo sapiens]",5,3,5,3,689,78.7,6.6,10.73,"other biological processes","other membranes;cytosol;ER/Golgi","","ARMH3","ENSG00000120029; ENSNLEG00000014964; ENSPTRG00000002879","","","",170.2,140.7,157,159.5,165.2,152.7,0.9801005446166737,-0.028998337721465664,0.7497148556131141,0.12510388351579235,0.8526982654955856,0.06920462042993089,6865]
["Medium","Q5T4F4-1","Protrudin [OS=Homo sapiens]",4,1,1,1,411,45.8,5.15,0,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ZFYVE27","ENSG00000155256","","","Endocytosis",34.3,35.9,22.8,25.9,38.2,31.4,0.9738219895287957,-0.03827001692771742,0.885829211884194,0.05265000213781738,0.9341645713657194,0.02957660756004848,7404]
["High","Q5T5U3-3","Isoform 3 of Rho GTPase-activating protein 21 [OS=Homo sapiens]",6,5,7,1,1164,129.2,8.44,11.46,"","","","","","","","",27.7,26,31.5,26.5,32.9,31,0.9424778761061947,-0.08546934218934943,0.526081224288725,0.2789471977909598,0.689086092810999,0.16172651496180188,5961]
["Medium","Q5T7M9-1","Protein FAM69A [OS=Homo sapiens]",3,1,1,1,428,49,7.17,0,"","other membranes;ER/Golgi","","DIPK1A","ENSG00000154511; ENSPCOG00000022059; ENSPTRG00000000964","","","",74.7,82.9,63.2,43,74.9,58.3,1.2531214528944383,0.3255262478577557,0.2421075094170127,0.6159917398941086,0.4243266966392896,0.3722996436083668,4455]
["High","Q5T8A7","Protein phosphatase 1 regulatory subunit 26 [OS=Homo sapiens]",1,1,1,1,1209,127.3,8.59,3.09,"other biological processes","nucleus","enzyme regulator activity","PPP1R26","ENSG00000196422","","","",19.6,18.5,21.4,33.8,19.1,25.4,0.7598978288633461,-0.39612263909573475,0.2223405831029286,0.6529812597074692,0.4017670152436164,0.396025721360064,4321]
["High","Q5TAX3","Terminal uridylyltransferase 4 [OS=Homo sapiens]",16,23,37,23,1644,185,7.97,69.36,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TUT4","ENSG00000134744","","Deadenylation of mRNA","",1519.8,1542.8,1575.9,1841.1,1759.3,1778.5,0.8623510383163845,-0.21365282633240198,1.1280354617868634E-3,2.947677247324065,0.022297976925650203,1.6517345382918895,395]
["High","Q5TC63","Growth hormone-regulated TBC protein 1 [OS=Homo sapiens]",11,3,6,3,336,38.5,8.78,2.46,"transport;other biological processes","","enzyme regulator activity","GRTP1","ENSG00000139835","","","",273,312,277.8,225.8,305.6,286,1.0555419623195494,0.0779839331397948,0.6046235304264834,0.21851495518082079,0.7488738143353398,0.12559135500368432,6304]
["High","Q5TFE4","5'-nucleotidase domain-containing protein 1 [OS=Homo sapiens]",40,11,29,11,455,51.8,6.35,39.56,"other metabolic processes","","other molecular function","NT5DC1","ENSG00000178425","","","",1287.4,1324.6,1355,1319.2,1239.4,1276.4,1.0344198174706647,0.04882181975498451,0.21919960450305878,0.6591602337747767,0.39793315786093536,0.4001898716702332,4301]
["High","Q5U4P2","Aspartate beta-hydroxylase domain-containing protein 1 [OS=Homo sapiens]",3,1,1,1,390,41.1,8.56,2.56,"protein metabolism;other metabolic processes","other membranes","other molecular function","ASPHD1","ENSG00000174939","16p11.2 proximal deletion syndrome","","",44.3,49.9,37.2,63.8,69.5,54.6,0.6993081426290578,-0.5159997910977263,0.02961231383055368,1.5285276566235015,0.11084033863325174,0.9553021560553782,2086]
["High","Q5VST6-1","Protein ABHD17B [OS=Homo sapiens]",6,2,5,2,288,32.2,6.29,9.62,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","Abhd17b; ABHD17B; FAM108B1; LOC111153563; LOC112838645","ENSAMEG00000007245; ENSBIXG00000020353; ENSBIXG00005014706; ENSBMUG00000011067; ENSBTAG00000006816; ENSCATG00000030905; ENSCHIG00000013948; ENSCSAG00000008296; ENSDLEG00000009276; ENSECAG00000020790; ENSG00000107362; ENSLCNG00005018778; ENSMFAG00000001017; ENSMMUG00000018880; ENSNLEG00000001017; ENSPANG00000025076; ENSPCOG00000021794; ENSPPAG00000033499; ENSPPYG00000019288; ENSRFEG00010009213; ENSRROG00000042653; ENSSBOG00000018778; ENSSSCG00070028547; ENSSSUG00005013616; ENSUAMG00000021312","","RAS processing; RAS processing","",98.1,92.2,115.3,73.3,74,81.2,1.337417943107221,0.4194503780903167,0.025241659985735316,1.5978820876632802,0.1015388362537977,0.9933678183930077,1941]
["High","Q5VT66-1","Mitochondrial amidoxime-reducing component 1 [OS=Homo sapiens]",31,8,27,7,337,37.5,8.88,56.93,"other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;other cell component","other molecular function","MTARC1","ENSG00000186205","","Phase I - Functionalization of compounds","",660.4,596.6,597.9,657.9,606.4,648.5,0.9697302383939775,-0.04434462373005911,0.504398935633738,0.29722583853210827,0.6728766255643648,0.1720645579876533,5853]
["High","Q5VTR2","E3 ubiquitin-protein ligase BRE1A [OS=Homo sapiens]",51,45,129,43,975,113.6,5.94,291.67,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNF20","ENSG00000155827","ATM signaling in development and disease","E3 ubiquitin ligases ubiquitinate target proteins; RHOBTB1 GTPase cycle","",5080.7,5195.5,5233.1,4686.5,4731.9,4688.4,1.099420137805881,0.13674281021743848,6.3123095994251186E-4,3.1998117084639537,0.017857432374025844,1.748180985870536,276]
["High","Q5VV42","threonylcarbamoyladenosine tRNA methylthiotransferase [OS=Homo sapiens]",23,8,16,8,579,65.1,7.46,36.1,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;ER/Golgi","other molecular function","CDKAL1","ENSG00000145996","Vitamin D receptor pathway","tRNA modification in the nucleus and cytosol","",213.2,217.9,231.9,231.5,229,241,0.9451176051318603,-0.08143423350731145,0.12798948534180815,0.8928257072708792,0.28198134919549606,0.549779615827257,3544]
["High","Q5VWN6-1","Protein FAM208B [OS=Homo sapiens]",7,12,15,12,2430,268.7,5.9,32.35,"","cytosol;nucleus","","TASOR2","ENSG00000108021","","","",513.8,528.6,546.9,586.1,565.5,566.6,0.9249796298451871,-0.11250650033400474,0.02122566534979195,1.6731386872694407,0.09131129203921518,1.0394755119829366,1815]
["Low","Q5VYS4-1","Mesenteric estrogen-dependent adipogenesis protein [OS=Homo sapiens]",3,1,1,1,303,34.2,6.3,0,"other biological processes","other cell component","","MEDAG","ENSG00000102802","","","",78.6,95.4,97,96,88.3,75,1.0451214809101426,0.06367064538793911,0.6701898656251479,0.17380214369912556,0.7961117405752557,0.09902597132085786,6573]
["High","Q5VZL5","Zinc finger MYM-type protein 4 [OS=Homo sapiens]",17,22,51,21,1548,172.7,6.84,94.29,"cell organization and biogenesis;developmental processes;other biological processes","","nucleic acid binding activity;other molecular function","ZMYM4","ENSG00000146463","","","",1880.7,1983.7,1916.9,2135,2278,2168.1,0.8784701645621552,-0.18693480600050003,0.007189796916775044,2.143283376539172,0.051267519932584056,1.290157691056674,1095]
["High","Q5XUX0-1","F-box only protein 31 [OS=Homo sapiens]",3,1,1,1,539,60.6,7.02,3.8,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","FBXO31","ENSG00000103264","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",24.9,21.3,23.4,15.5,18.6,14.6,1.4291581108829567,0.5151655337663861,0.012099458563951776,1.9172340633983551,0.06714468547785037,1.1729883561744654,1407]
["High","Q63HQ0","AP-1 complex-associated regulatory protein [OS=Homo sapiens]",7,3,5,3,302,34.3,4.87,9.71,"transport;other biological processes","cytosol;ER/Golgi;other cytoplasmic organelle","cytoskeletal activity;other molecular function","AP1AR","ENSG00000138660","","","",267.6,268.5,241,214.3,203.2,210.9,1.236632718014004,0.3064170810911382,0.006681836710613342,2.1751041417697348,0.0495929477532975,1.3045800769288196,1052]
["High","Q66K64","DDB1- and CUL4-associated factor 15 [OS=Homo sapiens]",12,5,8,5,600,66.4,6.58,21.51,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","DCAF15","ENSG00000132017; ENSG00000288453","","","",323.3,317.6,333,352.8,360.3,356.6,0.9104421800504816,-0.13536069679910814,0.00306086029217519,2.514156492592166,0.03380367349547933,1.47103610173043,707]
["High","Q676U5","Autophagy-related protein 16-1 [OS=Homo sapiens]",21,11,18,11,607,68.2,6.64,40.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","ATG16L1","ENSG00000085978; ENSG00000281089","Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy","Macroautophagy","Autophagy; Autophagy; NOD-like receptor signaling pathway; Shigellosis",657.4,648.6,639.5,732.3,638.1,672.9,0.9521362501835267,-0.07076005769965384,0.30874303563220307,0.510402830074357,0.49551194701258816,0.3049458700200924,4865]
["High","Q68CP9-1","AT-rich interactive domain-containing protein 2 [OS=Homo sapiens]",10,15,23,15,1835,197.3,7.42,48.14,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;nucleus","nucleic acid binding activity;other molecular function","ARID2","ENSG00000189079","","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Hepatocellular carcinoma",1068.5,1007,940.8,982,1070.8,1038.3,0.9758014946135679,-0.03534040187764322,0.6096737990037758,0.2149024685709693,0.7525028489758903,0.12349185149203795,6326]
["High","Q68D06","Schlafen family member 13 [OS=Homo sapiens]",3,2,2,2,897,102,6.96,6.51,"RNA metabolism OR transcription;other metabolic processes;stress response","other cell component","nucleic acid binding activity;other molecular function","SLFN13","ENSG00000154760","","","",64.3,63,62.2,57.1,69.3,71.1,0.959493670886076,-0.05965480489337357,0.5804654018055322,0.23622366094303537,0.7288957634766154,0.13733457399157303,6218]
["High","Q68E01-2","Isoform 2 of Integrator complex subunit 3 [OS=Homo sapiens]",12,10,34,10,1042,117.9,5.8,83.06,"","","","INTS3","","","","",1103.9,1060.5,1050.3,1028.4,1036.5,1046.6,1.0331672826610958,0.04707386342536431,0.11696982058344207,0.9319261762433378,0.26619071964894075,0.5748070896408758,3431]
["High","Q69YN2-1","CWF19-like protein 1 [OS=Homo sapiens]",18,6,14,6,538,60.6,7.24,36.93,"RNA metabolism OR transcription;other metabolic processes","nucleus","enzyme regulator activity","CWF19L1","ENSG00000095485","","","",278.4,254.6,272,340,320.1,336.9,0.8074222668004012,-0.30860472139621664,2.4533788094636176E-3,2.6102353901718125,0.030996734214064608,1.5086840606019927,618]
["High","Q6AI39","BRD4-interacting chromatin-remodeling complex-associated protein-like [OS=Homo sapiens]",2,2,2,2,1079,115,6.87,2.43,"other biological processes","nucleus","","BICRAL","ENSG00000112624","","","",98.5,77.1,53.9,86.5,76.6,92.2,0.8989424206815511,-0.15369938410594863,0.5631696350651979,0.24936076948941374,0.7170953213615566,0.1444231110131159,6132]
["High","Q6DD88","Atlastin-3 [OS=Homo sapiens]",24,9,18,9,541,60.5,5.66,40.43,"cell organization and biogenesis;other biological processes","other membranes;ER/Golgi","other molecular function","ATL3","ENSG00000184743","","","",817.4,797.6,794.6,844.8,854.4,883,0.9331577724421036,-0.099807071391616,0.013101369937536715,1.8826832902063713,0.06968358070319255,1.1568695411277876,1468]
["High","Q6F5E8","capping protein, Arp2/3 and myosin-I linker protein 2 [OS=Homo sapiens]",9,9,10,9,1435,154.6,6.76,20.36,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","CARMIL2","ENSG00000159753","","","",235,250.8,233,312.6,247.3,256.1,0.8808823529411762,-0.18297874334891648,0.20148309027097905,0.6957613967197189,0.37726138341386195,0.423357647034841,4170]
["High","Q6I9Y2","THO complex subunit 7 homolog [OS=Homo sapiens]",19,3,3,3,204,23.7,5.67,5.61,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","THOC7","ENSG00000163634","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Nucleocytoplasmic transport",168.9,161.3,206.5,190.5,182.9,168.2,0.990952732644018,-0.013111850801932026,0.9207955699745787,0.03583677880074862,0.9561872337227703,0.01945705896774137,7519]
["High","Q6IBS0","Twinfilin-2 [OS=Homo sapiens]",44,13,48,10,349,39.5,6.84,110.24,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","TWF2","ENSG00000247596","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",1784,1880.7,1807.4,1661.8,1841.9,1711.5,{"$f":"AVERAGE(T3906:V3906)/AVERAGE(W3906:Y3906)","v":1.0492598558061055},{"$f":"LOG(Z3906,2)","v":0.0693720146708677},{"$f":"TTEST(T3906:V3906,W3906:Y3906,2,2)","v":0.23363163176425011},{"$f":"-LOG10(AB3906)","v":0.6314683577469091},{"$f":"AB3906*7808/AF3906","v":0.41402537013510327},{"$f":"-LOG10(AD3906)","v":0.38297304590302245},4406]
["Medium","Q6IQ26","DENN domain-containing protein 5A [OS=Homo sapiens]",2,1,1,1,1287,147,6.65,0,"transport;other biological processes","other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","DENND5A","ENSG00000184014","","RAB GEFs exchange GTP for GDP on RABs","",10.9,15,11.8,10.1,13.1,16.5,0.9496221662468515,-0.07457448387429337,0.7797070229520631,0.1080685539983944,0.8713256669829267,0.05981949259410212,6987]
["Medium","Q6IQ55","tau-tubulin kinase 2 [OS=Homo sapiens]",1,1,1,1,1244,137.3,7.01,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","TTBK2","ENSG00000128881","Genes related to primary cilium development (based on CRISPR); Ciliopathies","Anchoring of the basal body to the plasma membrane","",78.9,77.7,72.5,75.8,74,76.2,1.0137168141592923,0.01965468600212532,0.6449949525502237,0.19044368395103092,0.7780195565444379,0.1090094863103259,6473]
["High","Q6N075","Molybdate-anion transporter [OS=Homo sapiens]",3,1,4,1,450,49.7,7.8,0,"transport","plasma membrane;other membranes","transporter activity","MFSD5","ENSG00000182544","","","",89,98,98.2,89.5,104.6,101,0.9664520501524906,-0.04922993898811921,0.5789631081061093,0.2373491089088282,0.7280631258000486,0.13783096409617598,6209]
["Medium","Q6NT16","MFS-type transporter SLC18B1 [OS=Homo sapiens]",2,1,1,1,456,48.8,5.22,0,"transport","other membranes","transporter activity","SLC18B1","ENSG00000146409","","","",10.1,9.2,9.7,15.7,16.9,11.6,0.6561085972850679,-0.6079934693764971,0.03562958089072368,1.4481892862068442,0.12458386367880453,0.9045382046196467,2233]
["High","Q6NUQ4","Transmembrane protein 214 [OS=Homo sapiens]",15,8,20,8,689,77.1,9.14,37.79,"other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi","","TMEM214","ENSG00000119777","","","",846.3,839.5,900.6,829.5,840.5,895.7,1.0080679736524147,0.011592922513348912,0.8185206847218542,0.08697034111819409,0.895475620892285,0.047946233216487326,7137]
["High","Q6NW29","RWD domain-containing protein 4 [OS=Homo sapiens]",11,2,5,2,188,21.2,5.31,10.8,"","","","RWDD4","ENSG00000182552","","","",177.2,191.4,174.7,199.4,176.3,182,0.9741796664873588,-0.03774022396931371,0.6096495670546415,0.21491973027871503,0.752710913909336,0.12337178688025104,6324]
["High","Q6NYC1","Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 [OS=Homo sapiens]",15,5,11,5,403,46.4,8.69,32.12,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","JMJD6","ENSG00000070495","","HDMs demethylate histones","",320.5,319.1,314.3,348.1,391.9,359,0.8679708826205643,-0.20428144876543008,0.022020730184998165,1.6571682843625504,0.09369910696701127,1.028264548292023,1835]
["High","Q6P1A2","Lysophospholipid acyltransferase 5 [OS=Homo sapiens]",10,4,10,4,487,56,8.69,17.01,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","LPCAT3","ENSG00000111684","Ferroptosis","Acyl chain remodelling of PC; Acyl chain remodelling of PS; Acyl chain remodelling of PE","Glycerophospholipid metabolism; Ferroptosis",324.6,327.4,334.4,275.9,366.4,339.2,1.0049923586347427,0.007184532049305574,0.9546086483193887,0.02017463544183145,0.975217104026925,0.010898690368170023,7643]
["High","Q6P1M0","Long-chain fatty acid transport protein 4 [OS=Homo sapiens]",16,7,9,7,643,72,8.47,24.82,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","SLC27A4","ENSG00000167114","PPAR signaling pathway; Fatty acid transporters","Transport of fatty acids; Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)","PPAR signaling pathway; Insulin resistance; Fat digestion and absorption",245.3,211.6,231.1,206,227.2,233.2,1.0324129651860745,0.046020164223912766,0.6034342188969438,0.21937006595959094,0.7482315993564138,0.12596395460301837,6297]
["High","Q6P1R4","tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like [OS=Homo sapiens]",16,5,5,5,473,53.2,8.29,5.5,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","DUS1L","ENSG00000169718","","","",130.5,105.6,109.8,125.4,131.7,127.4,0.8996098829648895,-0.15262858447626074,0.17946179956551173,0.7460279816454802,0.3500468975786949,0.45587376709194993,4003]
["High","Q6P4A8","Phospholipase B-like 1 [OS=Homo sapiens]",10,4,14,4,553,63.2,9.06,29.02,"other metabolic processes","non-structural extracellular;cytosol;other cytoplasmic organelle","other molecular function","PLBD1","ENSG00000121316","","Acyl chain remodelling of PC; Acyl chain remodelling of PE; Acyl chain remodelling of PI; Hydrolysis of LPC","",581.9,556.6,538.2,519.8,510.4,542.8,1.0659249841068024,0.09210591008090105,0.09550619558578279,1.019968454369749,0.23223680321824727,0.634068955277616,3211]
["High","Q6P4E1","Protein CASC4 [OS=Homo sapiens]",15,6,10,6,433,48.8,5.82,17.92,"","","","","","","","",314.4,322.8,333.6,258.9,269,275.2,1.208815838625327,0.2735944687891999,1.5715463589937885E-3,2.8036728032189573,0.02616339865889872,1.5823058412754052,469]
["High","Q6P9B6","TLD domain-containing protein 1 [OS=Homo sapiens]",12,4,7,4,456,51,6.24,17.31,"signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","","MEAK7","ENSG00000140950","","","",346.7,341.2,418.3,376.7,339.3,361.9,1.026254754615456,0.037388905992604755,0.7454124578571999,0.12760335328673109,0.8504062640194355,0.07037354949715836,6844]
["High","Q6PCT2-1","F-box/LRR-repeat protein 19 [OS=Homo sapiens]",2,2,3,2,694,75.7,9.17,1.75,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","FBXL19","ENSG00000099364; ENSGGOG00000003625; ENSPTRG00000008021","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",166,192,168.2,226.8,197.7,210.3,0.8289224952741021,-0.27069087966929267,0.03779232428017045,1.422596397550798,0.12947892408054887,0.8878009180725382,2279]
["High","Q6PD74","Alpha- and gamma-adaptin-binding protein p34 [OS=Homo sapiens]",18,4,21,4,315,34.6,4.64,69.18,"transport","cytosol;nucleus;other cell component","","AAGAB","ENSG00000103591","","","",799.2,829.8,850.6,748.7,774.5,705.7,1.1124770065951815,0.1537755178193341,0.028800250438084266,1.5406037357336453,0.10916133758279706,0.9619311514441634,2060]
["High","Q6PIW4","Fidgetin-like protein 1 [OS=Homo sapiens]",16,7,9,6,674,74,7.85,16.75,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","FIGNL1","ENSG00000132436","","","",127.1,156.7,157.8,155.2,195.5,167.6,0.8520162068300212,-0.23104722160653024,0.1764098192830323,0.7534772449312328,0.34616935636137625,0.46071137941898566,3979]
["High","Q6PJW8","Consortin [OS=Homo sapiens]",8,4,6,4,725,79.5,4.53,11.79,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","CNST","ENSG00000162852","","","",266.6,262.4,265.2,288.7,252.8,273.5,0.974478527607362,-0.037297698481333984,0.5442952574795077,0.26416544973483347,0.7036187699337743,0.15266258369732985,6040]
["High","Q6PL24","Protein TMED8 [OS=Homo sapiens]",13,3,5,3,325,35.7,4.74,10.14,"","","","TMED8","ENSG00000100580","","","",85.9,79.1,88.5,80.1,76.8,73.4,1.1007381676074686,0.13847133609785733,0.08562083217890912,1.0674205554207488,0.2174073033017634,0.662725870873549,3075]
["High","Q6RFH5-1","WD repeat-containing protein 74 [OS=Homo sapiens]",48,12,22,12,385,42.4,8.32,50.14,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","","WDR74","ENSG00000133316","","","",670.5,707.2,664.4,802.2,763.2,791.4,{"$f":"AVERAGE(T4034:V4034)/AVERAGE(W4034:Y4034)","v":0.8664714867617107},{"$f":"LOG(Z4034,2)","v":-0.20677581992119964},{"$f":"TTEST(T4034:V4034,W4034:Y4034,2,2)","v":0.00407428694737513},{"$f":"-LOG10(AB4034)","v":2.3899483873944942},{"$f":"AB4034*7808/AF4034","v":0.03874790802083436},{"$f":"-LOG10(AD4034)","v":1.4117517398552997},821]
["High","Q6UB35-1","Monofunctional C1-tetrahydrofolate synthase, mitochondrial [OS=Homo sapiens]",22,20,54,19,978,105.7,8.06,110.51,"other metabolic processes;developmental processes","cytosol;mitochondrion","other molecular function","MTHFD1L","ENSG00000120254","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism","Metabolism of folate and pterines","One carbon pool by folate; Metabolic pathways; Biosynthesis of cofactors",1925.7,1946.7,1966.3,2031.4,2071.1,2039.1,0.9506806044027615,-0.0729673677240548,0.003932594414704518,2.4053208419296053,0.038334203732850035,1.4164135533552074,801]
["High","Q6ULP2","Aftiphilin [OS=Homo sapiens]",9,6,9,6,937,102.1,4.54,14.03,"","","","","","","","",253.4,262.2,265.8,237.4,221,212.9,1.1640101295992853,0.2191036131079385,0.010539496108532092,1.9771801521704544,0.06262738631310394,1.203235712735581,1314]
["High","Q6UW68","Transmembrane protein 205 [OS=Homo sapiens]",9,1,5,1,189,21.2,8.62,8.89,"","other membranes","","TMEM205","ENSG00000105518","","","",66.9,81.6,63.3,72,72.3,61.3,1.0301556420233462,0.042862324798458216,0.771974607329068,0.11239698473969865,0.8676518978012614,0.061654478955418535,6947]
["High","Q6UWZ7","BRCA1-A complex subunit Abraxas 1 [OS=Homo sapiens]",9,4,5,4,409,46.6,7.05,6.94,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","cytoskeletal activity;other molecular function","ABRAXAS1","ENSG00000163322","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Homologous recombination",321.2,294.5,297.3,396.3,349.7,374.8,0.8145967166309779,-0.29584209555923374,0.012119787307301583,1.9165050016281302,0.06711439666341189,1.1731843096248749,1410]
["Medium","Q6UX68","XK-related protein 5 [OS=Homo sapiens]",1,1,1,1,686,74.9,6.68,0,"","","","","","","","",28.1,19,10.9,16.8,22.1,20,0.9847198641765702,-0.02221473381552661,0.9567731614140751,0.01919101564375774,0.9766616347654724,0.010255871907414789,7649]
["High","Q6V1X1","Dipeptidyl peptidase 8 [OS=Homo sapiens]",6,5,5,4,898,103.3,5.8,13.75,"protein metabolism;other biological processes","cytosol;other cell component","other molecular function","DPP8","ENSG00000074603","","","",259.7,261.9,264.6,264.1,260.7,255.7,1.0073030108904548,0.010497731558822792,0.5375507069003467,0.26958056268987735,0.6983687054039778,0.1559152300339815,6010]
["High","Q6VEQ5","WAS protein family homolog 2 [OS=Homo sapiens]",11,4,8,4,465,50.3,5.71,11.75,"cell organization and biogenesis;transport","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity","WASH2P","","","","",278.9,306.8,285.9,332.4,297.9,287.6,0.9495587754657372,-0.07467079230239201,0.387488100601436,0.4117416297318214,0.5716053446997945,0.24290371906445388,5293]
["High","Q6XZF7","Dynamin-binding protein [OS=Homo sapiens]",5,5,5,5,1577,177.2,5.39,9.6,"signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity","DNMBP","ENSG00000107554","","CDC42 GTPase cycle","",60.7,60.8,67.4,58.5,57.1,62.4,1.0612359550561798,0.08574546053460971,0.2533758269238014,0.5962348209220908,0.43643469151137027,0.3600807353221432,4533]
["High","Q6Y7W6-1","GRB10-interacting GYF protein 2 [OS=Homo sapiens]",34,41,102,40,1299,150,5.54,190.35,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GIGYF2","ENSG00000204120","VEGFA-VEGFR2 signaling pathway","","",3872.9,3660,3835.4,4138.3,3581,3682.8,0.9970356337867584,-0.004283027807755572,0.9539804159187559,0.02046054075263262,0.9748304001431286,0.011070935777274802,7641]
["High","Q6ZN17-1","Protein lin-28 homolog B [OS=Homo sapiens]",44,9,24,7,250,27.1,8.91,34.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","LIN28B","ENSG00000187772","Cardiac progenitor differentiation; Hippo-Merlin signaling dysregulation; Malignant pleural mesothelioma; CCL18 signaling pathway","","",491.1,491.7,478,650.3,559.4,555.2,0.8276956201484504,-0.27282777165023914,0.03185457717854517,1.4968281551477334,0.11606184722822242,0.9353105215309268,2143]
["High","Q6ZPD9-1","probable C-mannosyltransferase DPY19L3 [OS=Homo sapiens]",7,3,4,3,716,83.1,8.72,8.3,"protein metabolism;other metabolic processes","other membranes;nucleus","other molecular function","DPY19L3","ENSG00000178904; ENSPPAG00000028384","","","",13.7,28.4,19.7,23.2,21.1,17.7,0.9967741935483869,-0.004661377369863247,0.9890314024291224,0.004789919034592575,0.9947645485207507,0.002279700539374053,7763]
["High","Q6ZRS2","Helicase SRCAP [OS=Homo sapiens]",5,14,28,13,3230,343.3,5.96,54.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","SRCAP","ENSG00000080603","Pathways affected in adenoid cystic carcinoma","","",717.5,687.5,704.2,768.7,716.3,751.4,0.9431228760507958,-0.08448234824942973,0.07461195344757932,1.1271915894113063,0.19849067547485497,0.7022598903363042,2935]
["High","Q6ZTU2","EP400 N-terminal-like protein [OS=Homo sapiens]",5,1,1,1,488,51.7,7.27,0,"","","","EP400P1","","","","",21.6,13.1,20.5,19.4,15,14.8,1.121951219512195,0.16600995143892905,0.5493054181973389,0.26018611719637097,0.7065859481523594,0.1508350036129932,6070]
["High","Q6ZV29-1","Patatin-like phospholipase domain-containing protein 7 [OS=Homo sapiens]",1,2,4,1,1317,145.6,7.74,0,"","","","","","","","",21.6,23.7,20.6,24.9,30,22.4,0.8525226390685642,-0.23018994891679542,0.19081482136991296,0.7193878948878297,0.36391844779098204,0.4389959285556812,4094]
["High","Q6ZW49","PAX-interacting protein 1 [OS=Homo sapiens]",4,4,7,4,1069,121.3,6.7,24.58,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","","PAXIP1","ENSG00000157212","16p11.2 proximal deletion syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nonhomologous End-Joining (NHEJ)","",107.4,104.1,106.2,114,113.2,113.7,0.9319448518627164,-0.10168350942645359,1.4616689906361328E-3,2.8351509665138543,0.02530534695983797,1.5967877037331795,451]
["Medium","Q70CQ4-1","Ubiquitin carboxyl-terminal hydrolase 31 [OS=Homo sapiens]",1,2,2,2,1352,146.6,9.22,2.03,"protein metabolism;other metabolic processes","nucleus","other molecular function","USP31","ENSG00000103404","","","",70.2,73.5,66.9,52.4,57.8,54.6,1.2779126213592233,0.3537891938424986,0.003467472873379514,2.4599869277997883,0.035812206607602176,1.4459689186423594,756]
["High","Q70UQ0","Inhibitor of nuclear factor kappa-B kinase-interacting protein [OS=Homo sapiens]",20,8,17,5,350,39.3,9.17,28.46,"other biological processes","other membranes;ER/Golgi","","IKBIP","ENSG00000166130","","","",718.8,726.7,779.2,754.5,775.8,817.2,0.947689030883919,-0.07751435559461753,0.19625013747260758,0.7071900303606768,0.37084246693758954,0.4308105385496244,4132]
["High","Q712K3","Ubiquitin-conjugating enzyme E2 R2 [OS=Homo sapiens]",8,3,8,3,238,27.1,4.42,16.66,"protein metabolism;other metabolic processes","cytosol","other molecular function","UBE2R2","ENSG00000107341","","Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes","Ubiquitin mediated proteolysis",458.7,453,439.5,560,518.8,506.6,0.8522770278793995,-0.2306056482554522,0.01035779756964281,1.984732580984294,0.06187734003348972,1.2084683639062028,1307]
["High","Q71UM5","40S ribosomal protein S27-like [OS=Homo sapiens]",39,3,17,1,84,9.5,9.45,25.77,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;translational apparatus;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPS27L","ENSG00000185088","","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",170.4,171.9,185.5,213.7,186.1,213.2,0.861011419249592,-0.21589572325187573,0.051068002616428444,1.2918511280388627,0.15527218241007526,0.8089063427770431,2568]
["High","Q76NI1-1","Protein very KIND [OS=Homo sapiens]",3,4,4,4,1749,191.3,6.16,8.25,"developmental processes;signal transduction;other biological processes","other cell component","enzyme regulator activity","KNDC1","ENSG00000171798","","","",241.1,203.2,210.2,203.9,192.9,184.7,1.1255374032674117,0.1706140004720222,0.13239667256421495,0.878122929587855,0.2886772464064201,0.5395874459411224,3581]
["High","Q7KZF4","staphylococcal nuclease domain-containing protein 1 [OS=Homo sapiens]",55,49,244,49,910,101.9,7.17,624.26,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SND1","ENSG00000197157","VEGFA-VEGFR2 signaling pathway","Signaling by BRAF and RAF1 fusions","Viral carcinogenesis",9146.3,9352.1,9051.7,8292.7,8623.4,8547.3,1.0819489934572761,0.11363248750042677,0.006496412441073704,2.187326410614737,0.049151151492154536,1.3084663032472938,1032]
["High","Q7L190","Developmental pluripotency-associated protein 4 [OS=Homo sapiens]",54,15,66,15,304,33.5,9.52,153.1,"developmental processes","nucleus","other molecular function","DPPA4","ENSG00000121570","","POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","",3171.7,3275.3,3472.2,4729.3,4706.9,4642.2,0.7045687009887487,-0.5051877073824156,1.1260537580548212E-4,3.9484408756753773,0.00897166096213474,2.047127146709237,98]
["Low","Q7L211","Protein Abhd13 [OS=Homo sapiens]",2,1,1,1,337,38.5,8.57,1.73,"protein metabolism;other metabolic processes","other membranes;other cell component","other molecular function","ABHD13","ENSG00000139826","","","",45.9,40.6,48.1,49.1,46.5,37.5,1.0112697220135236,0.01616783869842523,0.9101259298341857,0.04089851224123951,0.9504163782459973,0.022086088229283624,7477]
["High","Q7L3B6","Hsp90 co-chaperone Cdc37-like 1 [OS=Homo sapiens]",15,5,10,5,337,38.8,5.34,21.18,"other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","CDC37L1","ENSG00000106993","","Platelet degranulation","",595.9,535.1,585.5,481.2,445.6,451.5,1.2453747369948487,0.3165799188854611,0.00661151844070429,2.1796987864014223,0.04930538298473648,1.3071056634216291,1047]
["High","Q7L5N7","Lysophosphatidylcholine acyltransferase 2 [OS=Homo sapiens]",6,3,4,3,544,60.2,6.55,8.36,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","LPCAT2","ENSG00000087253","","Acyl chain remodelling of PC","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways",138.1,110.1,123.1,107.3,120,121.2,1.0654232424677186,0.09142665909895455,0.4566023209422325,0.3404618852902807,0.6343684914442974,0.19765839620070638,5620]
["High","Q7L7L0","Histone H2A type 3 [OS=Homo sapiens]",35,6,156,1,130,14.1,11.05,351.11,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","H2AW","ENSG00000181218; ENSG00000284841","","HATs acetylate histones; HCMV Early Events; HCMV Late Events; Ub-specific processing proteases; UCH proteinases; RMTs methylate histone arginines; HDACs deacetylate histones; Metalloprotease DUBs","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus",71,17.8,26.7,31.1,21.5,32,1.3652482269503547,0.4491632831834703,0.5727723913053127,0.24201792399756136,0.7236580633190747,0.14046659442774176,6180]
["High","Q7LGA3-1","Heparan sulfate 2-O-sulfotransferase 1 [OS=Homo sapiens]",18,5,8,5,356,41.9,8.69,17.7,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","HS2ST1","ENSG00000153936; ENSGGOG00000040966; ENSPPAG00000039539; ENSPTRG00000000927","Metapathway biotransformation Phase I and II","HS-GAG biosynthesis","Glycosaminoglycan biosynthesis",437.9,408.7,405.4,410.1,395.9,382,1.0538720538720538,0.0756997261318525,0.1795952334272099,0.7457051939701116,0.3501322303619613,0.45576790973173265,4005]
["High","Q7RTS7","Keratin, type II cytoskeletal 74 [OS=Homo sapiens]",5,3,14,1,529,57.8,7.71,19.02,"cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","KRT74","ENSG00000170484","","Formation of the cornified envelope","",164.7,177,111.2,136.9,105,139.4,1.1877786519800682,0.24826600832399653,0.35866531404480106,0.44531062122568615,0.5440953510903063,0.2643249848172204,5147]
["High","Q7Z2W9","39S ribosomal protein L21, mitochondrial [OS=Homo sapiens]",42,6,14,6,205,22.8,9.89,31.77,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL21","ENSG00000197345","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",369.2,383.8,352.2,361.5,394.8,381.2,0.9716043956043956,-0.04155907804829157,0.46352997423346604,0.3339221768953405,0.6404604563466472,0.19350767953460332,5651]
["Low","Q7Z3D4","LysM and putative peptidoglycan-binding domain-containing protein 3 [OS=Homo sapiens]",4,1,1,1,306,34.5,5.97,0,"cell organization and biogenesis","plasma membrane;other membranes;ER/Golgi","","LYSMD3","ENSG00000176018","","","",32.6,26.9,30.2,31.8,29.4,37.3,0.9106598984771573,-0.13501573942447745,0.3635095546584335,0.43948416945171237,0.5477195296744595,0.2614417734428829,5182]
["High","Q7Z3E2","Coiled-coil domain-containing protein 186 [OS=Homo sapiens]",7,5,7,5,898,103.6,6.27,13.45,"cell-cell signaling;transport;other biological processes","ER/Golgi","other molecular function","CCDC186","ENSG00000165813","","","",244.4,223.3,213.9,234.4,210.7,221.2,1.0229626294461955,0.03275344195770156,0.6758912712656341,0.1701231621756031,0.7999634752223845,0.09692984159742055,6597]
["High","Q7Z408","CUB and sushi domain-containing protein 2 [OS=Homo sapiens]",0,1,1,1,3487,379.8,6.09,2.32,"","plasma membrane;other membranes","","CSMD2","ENSG00000121904","","","",34.3,23.9,31.5,34.9,34.1,31,0.8969999999999998,-0.15682010974282617,0.3603754270884425,0.44324482991197317,0.5455237174692825,0.26318636305525644,5158]
["High","Q7Z4H8","KDEL motif-containing protein 2 [OS=Homo sapiens]",19,9,16,9,507,58.5,8.24,29.07,"protein metabolism;other metabolic processes","ER/Golgi;other cell component","other molecular function","POGLUT3","ENSG00000178202","","","",864.7,868.5,873.5,960.6,989.2,964.4,0.8944821906526661,-0.1608753367162266,3.888517458820277E-4,3.410215946791849,0.014527054697831925,1.8378224282442674,209]
["High","Q7Z4L5","Tetratricopeptide repeat protein 21B [OS=Homo sapiens]",7,7,7,7,1316,150.8,6.96,16,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","TTC21B","ENSG00000123607","Nephrotic syndrome; Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",244.7,269.2,250.3,201.8,243.8,232.9,1.1263080324244659,0.17160144205129485,0.12209654411943409,0.9132966283655218,0.27386665225065826,0.5624608469911748,3481]
["High","Q7Z4W1","L-xylulose reductase [OS=Homo sapiens]",58,10,24,10,244,25.9,8.1,64.3,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","DCXR","ENSG00000169738","","Formation of xylulose-5-phosphate; Essential pentosuria","Pentose and glucuronate interconversions; Metabolic pathways",779.9,792.8,804.5,408.9,468.6,442.5,1.8009090909090908,0.8487253564774644,4.6522598824838572E-5,4.332336032899693,6.3727798530585885E-3,2.19567108391355,57]
["High","Q7Z624","Calmodulin-lysine N-methyltransferase [OS=Homo sapiens]",7,2,4,2,323,36.1,6.83,7.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","CAMKMT","ENSG00000143919","","Inactivation, recovery and regulation of the phototransduction cascade; Protein methylation","Lysine degradation; Metabolic pathways",158.6,174.3,144.7,158.1,195.6,156.2,0.9366542459305746,-0.0944115013637544,0.5234097308055274,0.2811582075733612,0.6870852686835168,0.1629893627646424,5948]
["High","Q7Z628","Neuroepithelial cell-transforming gene 1 protein [OS=Homo sapiens]",10,4,5,4,596,67.7,9.23,11.26,"stress response;signal transduction;other biological processes","cytosol;nucleus","enzyme regulator activity","NET1","ENSG00000173848","Apoptosis-related network due to altered Notch3 in ovarian cancer","RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events","",150.6,158.2,168.8,154.6,186.4,149.8,0.9731051344743276,-0.039332412398100085,0.7452842748265547,0.12767804209740533,0.8503842785102643,0.07038477743508095,6843]
["High","Q7Z6M1-1","Rab9 effector protein with Kelch motifs [OS=Homo sapiens]",20,6,9,6,372,40.5,6.25,17.75,"transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","RABEPK","ENSG00000136933","","Retrograde transport at the Trans-Golgi-Network","",505.3,501.4,511.2,502.2,527.2,513,0.984115663900415,-0.023100208256683227,0.353056351943012,0.4521559705762722,0.5386213356723404,0.2687164474688034,5118]
["High","Q7Z739","YTH domain-containing family protein 3 [OS=Homo sapiens]",19,10,30,6,585,63.8,9.04,50.5,"cell organization and biogenesis;other biological processes","cytosol;other cell component","translation activity;nucleic acid binding activity","YTHDF3","ENSG00000185728","","","",709.1,770.7,787.9,777.5,728.7,763.9,0.9989427778511962,-1.5260559835071743E-3,0.9785699708455486,0.009408115467735083,0.9887000947673452,0.004935424216536609,7728]
["High","Q7Z7H5","Transmembrane emp24 domain-containing protein 4 [OS=Homo sapiens]",34,7,49,5,227,25.9,8.28,112.09,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED4","ENSG00000158604","","","",793,804.9,804.6,756.4,803,753.8,1.0386045305204912,0.05464642376498659,0.144763972822692,0.8393395068618669,0.30393038445807447,0.5172258805622042,3719]
["High","Q86SQ9","Dehydrodolichyl diphosphate synthase complex subunit DHDDS [OS=Homo sapiens]",17,4,7,4,333,38.6,8.28,10.61,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DHDDS","ENSG00000117682","","Synthesis of Dolichyl-phosphate; Defective DHDDS causes retinitis pigmentosa 59","Terpenoid backbone biosynthesis",111.5,94.6,94,95.7,85.9,95.8,1.081831290555155,0.11347553127468563,0.3161146126710954,0.5001554280587405,0.503000386332976,0.2984316813810205,4907]
["High","Q86TB9","Protein PAT1 homolog 1 [OS=Homo sapiens]",18,8,9,8,770,86.8,6.67,25.84,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","PATL1","ENSG00000166889","","mRNA decay by 5' to 3' exoribonuclease","RNA degradation",310.6,331.6,313,320.7,284.6,300.5,1.0545374254802387,0.07661029721469363,0.2541131059660595,0.5949729354928905,0.43712604789226545,0.35939331357710425,4539]
["High","Q86TM6","E3 ubiquitin-protein ligase synoviolin [OS=Homo sapiens]",8,4,9,4,617,67.6,6.95,9.07,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","SYVN1","ENSG00000162298","","Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; XBP1(S) activates chaperone genes; ER Quality Control Compartment (ERQC)","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",898.8,679.8,642.1,265.5,247.9,268.9,2.8386808129873446,1.5052206386331077,0.003950582354477088,2.403338880400364,0.038365854507160575,1.4160551244901796,804]
["High","Q86U42-1","polyadenylate-binding protein 2 [OS=Homo sapiens]",69,14,44,14,306,32.7,5.06,93.31,"RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BCL2L2; BCL2L2-PABPN1; LOC101332651; LOC102975296; LOC106988220; LOC109255027; LOC110585402; LOC111164107; LOC112822568; LOC116541350; PABPN1","ENSCATG00000038536; ENSCCAG00000033954; ENSCJAG00000007960; ENSDLEG00000019901; ENSFCAG00000031922; ENSG00000100836; ENSGGOG00000022683; ENSMMUG00000014747; ENSMNEG00000045065; ENSOGAG00000008710; ENSPANG00000021100; ENSPTRG00000006167; ENSSSCG00000002023","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA surveillance pathway; Influenza A",1861.8,1844.3,1950.4,2419.8,2286.8,2371.9,0.7991099809281628,-0.32353402099517886,7.4014229897608321E-4,3.1306847752434237,0.018642035710984703,1.729506664419061,310]
["High","Q86U90","YrdC domain-containing protein, mitochondrial [OS=Homo sapiens]",11,2,4,2,279,29.3,8.57,12.78,"other biological processes","other membranes;mitochondrion;other cell component","nucleic acid binding activity;other molecular function","YRDC","ENSG00000196449","","","",282.4,305,297.1,300.9,293.6,284.5,1.0062571103526734,0.00899897754705421,0.832955679443174,0.07937810625868813,0.9046763033930035,0.04350678521158775,7189]
["High","Q86UK7-1","E3 ubiquitin-protein ligase ZNF598 [OS=Homo sapiens]",16,12,23,12,904,98.6,8.4,54.84,"protein metabolism;other metabolic processes","","translation activity;other molecular function","ZNF598","","","","",703.8,683.2,703.1,710.9,632.1,664,1.041405082212257,0.05853135242513753,0.31023111981395785,0.5083146395153458,0.49708282033806334,0.3035712462380051,4873]
["High","Q86UV5","Ubiquitin carboxyl-terminal hydrolase 48 [OS=Homo sapiens]",22,15,29,15,1035,119,6.05,61.63,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","USP48","ENSG00000090686","","Ub-specific processing proteases","",1289.6,1400.2,1288.3,1417,1478,1527.5,0.8995138496325609,-0.15278260035624933,0.03893460280158038,1.4096642514792435,0.132117070262816,0.8790410654892513,2301]
["High","Q86V21-1","acetoacetyl-CoA synthetase [OS=Homo sapiens]",19,14,38,14,672,75.1,6.24,75.73,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol","other molecular function","AACS","ENSG00000081760","","Synthesis of Ketone Bodies","Valine, leucine and isoleucine degradation; Butanoate metabolism; Metabolic pathways",1674.2,1727.7,1703.4,1380.7,1572.8,1473.1,1.153323092215244,0.20579672655482228,0.017120555647509195,1.7664821444058778,0.08141126583176114,1.0893154925306643,1642]
["Medium","Q86VI4-1","Lysosomal-associated transmembrane protein 4B [OS=Homo sapiens]",2,1,5,1,370,41.1,8.97,1.63,"","","","","","","","",63.2,69.9,68.4,76,61.6,70.6,0.9678194044188282,-0.04719022988408717,0.657107926053476,0.18236329430617065,0.7871584361192914,0.10393784577666061,6518]
["High","Q86VP3-1","Phosphofurin acidic cluster sorting protein 2 [OS=Homo sapiens]",3,2,3,2,889,97.6,6.6,3.91,"cell organization and biogenesis;other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","PACS2","ENSG00000179364","","","",169.5,170.6,179.2,153.2,171.2,157.5,1.0776094625440964,0.1078344243478058,0.11612789768533333,0.9350634361152045,0.2648150190207601,0.5770573874616847,3424]
["High","Q86W42","THO complex subunit 6 homolog [OS=Homo sapiens]",34,8,18,8,341,37.5,7.43,38.82,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity","THOC6","ENSG00000131652","","mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","Nucleocytoplasmic transport",575.6,605.5,624.4,550.4,573.4,574,1.063435033572859,0.0887319001484794,0.09089395422652735,1.0414650027337855,0.22494453077677512,0.6479245616553033,3155]
["High","Q86WA8","Lon protease homolog 2, peroxisomal [OS=Homo sapiens]",4,3,5,3,852,94.6,7.3,4.92,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","LONP2","ENSG00000102910","IL-18 signaling pathway","Peroxisomal protein import; Association of TriC/CCT with target proteins during biosynthesis","",212.9,191.8,175.4,193.3,181.2,184.4,1.0379316514582217,0.05371144432311035,0.5702386487095936,0.24394335112251503,0.7218585228801082,0.14154791150678014,6168]
["High","Q86WP2-1","Vasculin [OS=Homo sapiens]",2,1,1,1,473,53.3,7.05,2.89,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","GPBP1","ENSG00000062194; ENSGGOG00000008390","","","",70.4,54.6,62,110.9,60.9,85.7,0.7262135922330097,-0.461534162182944,0.19553113320068122,0.7087840827654426,0.3702005548086612,0.43156293471828616,4124]
["High","Q86X10-1","Ral GTPase-activating protein subunit beta [OS=Homo sapiens]",12,12,19,12,1494,166.7,6.79,32.52,"other biological processes","","enzyme regulator activity;other molecular function","RALGAPB","ENSG00000170471","","Translocation of SLC2A4 (GLUT4) to the plasma membrane","",357.4,357.8,380,370.4,327.4,349.8,1.0454371897670867,0.06410638690730332,0.33499977229108907,0.4749554881654148,0.5219872724104617,0.28234008624925605,5011]
["High","Q86X76","Deaminated glutathione amidase [OS=Homo sapiens]",37,9,18,9,327,35.9,7.74,42,"other metabolic processes","mitochondrion;other cell component","other molecular function","NIT1","ENSG00000158793","","","",1054.8,1062.9,1095.4,983.4,1049.6,1021.3,1.0519922731886193,0.07312410817261146,0.0813529363247758,1.0896267671692481,0.21061131525989704,0.6765182997083491,3016]
["High","Q86XP3-1","ATP-dependent RNA helicase DDX42 [OS=Homo sapiens]",43,29,100,29,938,102.9,7.02,237.53,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX42","ENSG00000198231","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",3539.8,3661.4,3585.5,3631.7,3675.6,3742.4,0.9761984488266652,-0.03475363558749628,0.14112337524409607,0.8504010450782099,0.29926434380931616,0.5239450245875704,3682]
["High","Q86Y37","CDK2-associated and cullin domain-containing protein 1 [OS=Homo sapiens]",20,6,10,6,369,41,5.19,30.34,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","","other molecular function","CACUL1","ENSG00000151893","","","",240.1,232.4,228.4,237.3,232.2,268.4,0.949857704295975,-0.07421669163608892,0.3557447902763899,0.4488614512458793,0.5409260608525905,0.2668620945205408,5135]
["High","Q86Y91","Kinesin-like protein KIF18B [OS=Homo sapiens]",2,2,2,2,864,94.2,8.79,4.48,"","","","","","","","",194.9,190.1,197.3,182.2,169.1,175.3,1.1057728826433728,0.14505509738875735,0.012819999596652625,1.8921119884811282,0.06889095447395988,1.1618377981205144,1453]
["Low","Q86YF9","Zinc finger protein DZIP1 [OS=Homo sapiens]",1,1,1,1,867,98.6,6.15,0,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DZIP1","ENSG00000134874","","Hedgehog 'on' state","",66.7,63.5,51.6,64.3,56.6,67.4,0.9654806160382366,-0.050680800420121457,0.7187446610544569,0.14342536829633087,0.83078583471698,0.08051091699574484,6755]
["High","Q86YS3","rab11 family-interacting protein 4 [OS=Homo sapiens]",3,2,2,1,637,71.9,4.87,2.45,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB11FIP4","ENSG00000131242","","","Endocytosis",21.1,22.4,17.3,13.4,20.9,13.9,1.2614107883817427,0.33503817721362383,0.21639906002686599,0.6647446300073898,0.3950535096305283,0.40334407560556546,4277]
["High","Q86YZ3","Hornerin [OS=Homo sapiens]",7,5,10,5,2850,282.2,10.04,25.5,"cell organization and biogenesis;developmental processes","non-structural extracellular;plasma membrane;other cytoplasmic organelle;other cell component","other molecular function","HRNR","ENSG00000197915","","Neutrophil degranulation","",402.8,331.1,270.5,404.9,300.6,498.3,0.834357866755275,-0.26126178812982853,0.38821031106896187,0.4109329337058152,0.5719143601559348,0.24266899864796884,5300]
["High","Q8IUD2-1","ELKS/Rab6-interacting/CAST family member 1 [OS=Homo sapiens]",41,43,115,37,1116,128,5.97,231.63,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","ERC1","ENSG00000082805","","","NF-kappa B signaling pathway",4824.9,4485.4,4665.9,4746.3,4404.1,4335.1,1.0363872307293016,0.051563145373021334,0.3659538136581742,0.4365737226359502,0.5501284899967316,0.25953586327059874,5194]
["Low","Q8IUM7","Neuronal pas domain-containing protein 4 [OS=Homo sapiens]",2,1,1,1,802,87.1,4.64,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NPAS4","ENSG00000174576","Orexin receptor pathway","","",28.4,26.7,23.4,26.7,17.4,19.7,1.230407523510972,0.29913623001412015,0.19574767856545508,0.7083033796771256,0.3704308953560526,0.4312927986556231,4126]
["High","Q8IV08","Phospholipase D3 [OS=Homo sapiens]",12,5,19,5,490,54.7,6.47,34.28,"DNA metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","PLD3","ENSG00000105223","","Role of phospholipids in phagocytosis; Synthesis of PG","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways",629.3,623.3,612.1,480.3,546.2,514.8,1.209822876792318,0.2747958462782794,0.005413788509256961,2.2664987140359054,0.044683785074290015,1.3498500457790625,946]
["High","Q8IVD9","NudC domain-containing protein 3 [OS=Homo sapiens]",56,15,49,15,361,40.8,5.25,78.44,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","other molecular function","NUDCD3","ENSG00000015676","","","",1259.5,1180.5,1162.9,1055.4,1010.5,1009.6,1.1714843114940658,0.22833763377316554,0.006193516648580847,2.2080626906558645,0.04831066732479446,1.3159569634765476,1001]
["High","Q8IVL5","Prolyl 3-hydroxylase 2 [OS=Homo sapiens]",8,5,9,4,708,80.9,5.71,16.09,"protein metabolism;other metabolic processes;other biological processes","extracellular matrix;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","P3H2","ENSG00000090530","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",143.4,127,116.7,123.7,137,138.5,0.969689378757515,-0.04440541304494938,0.6800785518817531,0.167440921590056,0.8035794995600376,0.0949711512437464,6608]
["Medium","Q8IVV7","Glucose-induced degradation protein 4 homolog [OS=Homo sapiens]",4,1,1,1,300,33.5,9.16,2.55,"protein metabolism;other metabolic processes","other cell component","other molecular function","GID4","ENSG00000141034","Ciliary landscape","","",34.2,33.2,26.6,29.1,39.1,41.4,0.8576642335766423,-0.221515136395527,0.3089257093325746,0.5101459474555748,0.49570323437499847,0.3047782473917391,4866]
["Medium","Q8IWB1","Inositol 1,4,5-trisphosphate receptor-interacting protein [OS=Homo sapiens]",1,1,1,1,547,62,5.88,2.41,"other biological processes","plasma membrane;other membranes;nucleus","enzyme regulator activity","ITPRIP","ENSG00000148841","","","",64.6,67.4,61.7,83.1,68.2,91.6,{"$f":"AVERAGE(T4482:V4482)/AVERAGE(W4482:Y4482)","v":0.7974475092630712},{"$f":"LOG(Z4482,2)","v":-0.32653853603261135},{"$f":"TTEST(T4482:V4482,W4482:Y4482,2,2)","v":0.08011417628154852},{"$f":"-LOG10(AB4482)","v":1.096290628284015},{"$f":"AB4482*7808/AF4482","v":0.20837158174761186},{"$f":"-LOG10(AD4482)","v":0.6811615115326313},3002]
["Medium","Q8IWE2","Protein Noxp20 [OS=Homo sapiens]",4,1,1,1,563,60.7,4.68,0,"","cytosol;ER/Golgi;nucleus","","FAM114A1","ENSG00000197712","","","",23.5,21.4,22,26.3,33.9,29.3,0.7474860335195531,-0.41988147151015776,0.030495332426556703,1.5157666280799373,0.11300785742124098,0.9468913590294021,2107]
["High","Q8IWR0","Zinc finger CCCH domain-containing protein 7A [OS=Homo sapiens]",19,17,27,17,971,110.5,7.3,67.19,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZC3H7A","ENSG00000122299","","","",1225.5,1316.7,1223,1347.5,1298.3,1384.9,0.9341305480437639,-0.09830390913437184,0.08989495635267246,1.046264674113823,0.22389148937852202,0.649962414621923,3135]
["Low","Q8IWV2","Contactin-4 [OS=Homo sapiens]",1,1,2,1,1026,113.4,7.47,4.22,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","other molecular function","CNTN4","ENSG00000144619","","Post-translational modification: synthesis of GPI-anchored proteins","",197.9,184.2,197.7,180,196.6,173.2,1.0545652964714443,0.07664842654844378,0.2945658619447288,0.5308175861699166,0.48106468313416484,0.31779652520707063,4781]
["High","Q8IWZ6-1","Bardet-Biedl syndrome 7 protein [OS=Homo sapiens]",2,1,1,1,715,80.3,6.05,2.13,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BBS7","ENSG00000138686; ENSGGOG00000002169","Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","BBSome-mediated cargo-targeting to cilium","",29.1,29.5,25.1,35.3,27.4,37.7,0.8336653386454184,-0.26245974140042816,0.17830748343648375,0.7488304294159566,0.3487537150982127,0.4574811573726547,3992]
["Medium","Q8IX21","SMC5-SMC6 complex localization factor protein 2 [OS=Homo sapiens]",1,1,1,1,1173,131.8,8.97,2.07,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","SLF2","ENSG00000119906","","","",72.6,74.4,90.8,73.5,93.5,64.2,1.028546712802768,0.04060731724497691,0.8428690451406208,0.07423989558960811,0.9101260551041304,0.04089845246485014,7231]
["High","Q8IXI1","Mitochondrial Rho GTPase 2 [OS=Homo sapiens]",27,10,32,9,618,68.1,5.86,88.53,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion","other molecular function","RHOT2","ENSG00000140983","","RHOT2 GTPase cycle","Mitophagy",964.8,946.8,952.7,965.8,941.3,985.4,0.9902506482281764,-0.014134354354266784,0.5335315249713486,0.2728399141652756,0.6955775833989464,0.15765442259084894,5989]
["Medium","Q8IXQ4","GPALPP motifs-containing protein 1 [OS=Homo sapiens]",2,1,2,1,340,38.1,5.41,2.83,"","","","GPALPP1","ENSG00000133114","","","",113.6,105,102.1,237,157.6,103.5,0.6438466171451516,-0.6352110572309405,0.20331298434959597,0.6918348847593462,0.3789610364768788,0.4214054404619303,4189]
["High","Q8IXU6-1","Solute carrier family 35 member f2 [OS=Homo sapiens]",10,2,5,2,374,41.2,6.21,10.53,"transport","other membranes","transporter activity","SLC35F2","ENSG00000110660","","","",188.1,179.4,185.6,197.6,187.2,176.1,0.9860937778570156,-0.020203240965859695,0.7187160643839137,0.1434426479005657,0.830875781864021,0.08046389954132305,6754]
["Medium","Q8IY26","Phospholipid phosphatase 6 [OS=Homo sapiens]",3,1,2,1,295,32.2,9.99,1.67,"other metabolic processes","plasma membrane;other membranes","other molecular function","PLPP6","ENSG00000205808","","Cholesterol biosynthesis","",27.8,24.9,25.5,31.4,28.7,31.1,0.8574561403508774,-0.22186521685738914,0.024337381434998025,1.6137261512295507,0.099075221191066,1.00403494940556,1918]
["High","Q8IY67-2","Isoform 2 of Ribonucleoprotein PTB-binding 1 [OS=Homo sapiens]",24,11,49,11,739,77.8,8.84,96.33,"","","","RAVER1","","","","",1506.6,1515.4,1545.7,1538,1517.6,1585.7,0.984142373903863,-0.023061052425711066,0.35354930915304567,0.451550007044838,0.5391626964583947,0.26828016336203336,5120]
["High","Q8IYB7","DIS3-like exonuclease 2 [OS=Homo sapiens]",20,15,30,15,885,99.2,6.1,63.11,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","other cell component","nucleic acid binding activity;other molecular function","DIS3L2","ENSG00000144535","","","",1741.5,1666.8,1642.2,1630.2,1574,1626.4,1.0455222953670351,0.06422382718095591,0.10384495145245698,0.9836146123656233,0.24637538162892256,0.6084026900013615,3291]
["High","Q8IYS1","Peptidase M20 domain-containing protein 2 [OS=Homo sapiens]",6,2,2,2,436,47.7,5.85,0,"protein metabolism;other biological processes","nucleus","other molecular function","PM20D2","ENSG00000146281","","","",39.5,33.9,31.1,37.3,43.1,43.6,0.842741935483871,-0.24683717830599242,0.11136426709507392,0.9532541367462622,0.2573341809642904,0.5895025238625232,3379]
["High","Q8IYS2-1","Uncharacterized protein KIAA2013 [OS=Homo sapiens]",10,5,6,5,634,69.1,8.19,19.27,"","other membranes","","KIAA2013","ENSG00000116685","","","",206.2,205.5,182.4,172.1,161.6,162.7,1.1968170829975826,0.25920267306880523,0.01859295858428922,1.7306514980927208,0.08539636507419426,1.0685606148123592,1700]
["High","Q8IZ40","REST corepressor 2 [OS=Homo sapiens]",37,15,40,15,523,58,9.01,101.75,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","RCOR2","ENSG00000167771","","","",1279.8,1347.1,1272.2,1526.5,1500.2,1435.3,0.8738458090542357,-0.1945493576528559,0.006507257217170557,2.186602026247547,0.049137973260800494,1.3085827603468354,1034]
["Medium","Q8IZE3","Protein-associating with the carboxyl-terminal domain of ezrin [OS=Homo sapiens]",1,1,1,1,742,82.8,5.05,2.05,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","SCYL3","ENSG00000000457","","","",156.6,164.7,137.7,124.2,128.2,132.2,1.1934477379095163,0.255135390961273,0.040795413719925205,1.3893886581867148,0.1359498891699428,0.8666211421250423,2343]
["High","Q8IZQ5","Selenoprotein H [OS=Homo sapiens]",34,4,10,4,122,13.4,9.74,17.95,"","ER/Golgi","","SELENOH","ENSG00000211450","Selenium micronutrient network","","",521.9,479.4,519.1,422.3,346.6,368.4,1.3368504352413608,0.418838067970165,0.008365698976890866,2.0774977667010344,0.05540235590463433,1.256471767137488,1179]
["High","Q8IZT6-1","Abnormal spindle-like microcephaly-associated protein [OS=Homo sapiens]",3,9,12,9,3477,409.5,10.45,16.43,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","ASPM","ENSG00000066279","","","",411.4,460.3,425.9,274.1,273.4,294.6,1.5409096306851917,0.6237822549835924,7.017401983565615E-4,3.153823644713313,0.018386535130094066,1.7355001041309328,298]
["Medium","Q8N0Z8","tRNA pseudouridine synthase-like 1 [OS=Homo sapiens]",4,1,1,1,303,33.2,9.85,2.27,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","PUSL1","ENSG00000169972","","","",82.1,75.6,75.3,92.4,78.3,77.2,0.9398951189995968,-0.08942831654507939,0.4076059478471084,0.3897594873291743,0.5896956162294279,0.22937210073575273,5397]
["Medium","Q8N118","Cytochrome P450 4X1 [OS=Homo sapiens]",1,1,1,1,509,58.8,8.48,0,"","other membranes;ER/Golgi","other molecular function","CYP4X1","ENSG00000186377","Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II","","Serotonergic synapse",22,19.4,17.7,25.4,23.9,28.8,0.7567221510883483,-0.40216441796444685,0.029696697509475515,1.5272918447285153,0.11083738726289905,0.9553137202651166,2092]
["High","Q8N1G1","RNA exonuclease 1 homolog [OS=Homo sapiens]",6,6,6,6,1221,131.4,8.95,10.33,"other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","REXO1","ENSG00000079313","","","Ribosome biogenesis in eukaryotes",356.9,339.5,349.8,321.6,303.7,325.8,1.0999894858584798,0.13748973395691266,0.019933475741918474,1.7004169680368482,0.08783328363030442,1.0563408809292447,1772]
["High","Q8N257","Histone H2B type 3-B [OS=Homo sapiens]",58,9,328,1,126,13.9,10.32,686.55,"cell organization and biogenesis","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","H2BU1","ENSG00000196890; ENSG00000285449","","Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Assembly of the ORC complex at the origin of replication; HATs acetylate histones; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Amyloid fiber formation; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Meiotic synapsis; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; HCMV Early Events; HCMV Late Events; HDACs deacetylate histones","Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis; Systemic lupus erythematosus",809.4,851.7,880,789.6,788.5,748.9,1.0920068758057584,0.12698194019516476,0.04352639558596052,1.3612472952120107,0.14107683550650882,0.8505442905517185,2409]
["High","Q8N2F6-1","Armadillo repeat-containing protein 10 [OS=Homo sapiens]",17,4,6,4,343,37.5,6.61,13.58,"other biological processes","other membranes;mitochondrion;ER/Golgi","other molecular function","ARMC10","ENSG00000170632","","","",307.4,317.8,298.6,278.3,306.4,278.9,1.069708198239926,0.09721730282653156,0.1367786061584029,0.863981826255852,0.29412485730785176,0.5314682705101089,3631]
["High","Q8N339","Metallothionein-1M [OS=Homo sapiens]",36,2,12,1,61,6.1,7.69,19.87,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1M","ENSG00000205364","Zinc homeostasis","Metallothioneins bind metals","Mineral absorption",11.2,11.7,17,10.7,12.8,16.8,0.9900744416873449,-0.014391092305621562,0.9612270644216652,0.01717400964975317,0.9791599372477966,0.009146364181511784,7665]
["High","Q8N3P4-1","Vacuolar protein sorting-associated protein 8 homolog [OS=Homo sapiens]",4,4,5,3,1428,161.7,5.64,6.06,"cell organization and biogenesis;transport","other cytoplasmic organelle","other molecular function","VPS8","ENSG00000156931","","","",18.5,10.8,14.9,17,15.7,17.2,0.8857715430861722,-0.17499344594582916,0.4503320516213929,0.3464671417625066,0.6286773930019374,0.20157215643211943,5593]
["High","Q8N3X1","Formin-binding protein 4 [OS=Homo sapiens]",13,10,17,10,1017,110.2,4.74,30.6,"","nucleus","","FNBP4","ENSG00000109920; ENSG00000285182","","","",552.4,516.8,557.1,678.2,642.6,689.9,0.8088227980305364,-0.30610443228781214,0.002561383985772961,2.591525310090061,0.031396053627810484,1.5031249377667761,637]
["High","Q8N488","RING1 and YY1-binding protein [OS=Homo sapiens]",41,8,28,8,228,24.8,9.63,46.92,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RYBP","ENSG00000163602","","Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",548,614.8,596.3,602.2,531.6,574.6,1.0296768906579254,0.04219169529611768,0.5864675372988304,0.23175602235863368,0.7343070127051423,0.13412232421680237,6236]
["High","Q8N4C6","ninein [OS=Homo sapiens]",3,6,8,5,2090,243.1,5.03,7.68,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","NIN","ENSG00000100503","","","",83.6,82.8,98.1,97.9,89,88,0.9621680611131321,-0.05563918451156502,0.5874186826690392,0.2310522449922423,0.7353800022895395,0.13348818438473853,6237]
["High","Q8N4V1","Membrane magnesium transporter 1 [OS=Homo sapiens]",25,2,6,2,131,14.7,9.16,13.27,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity","MMGT1","ENSG00000169446","","Miscellaneous transport and binding events","",430,476.4,447.2,371.6,479.1,434,1.0536311979450455,0.07536996943735919,0.5361917694289726,0.2706798567444378,0.6976479479589099,0.15636367885189884,6001]
["High","Q8N5A5-1","Zinc finger CCCH-type with G patch domain-containing protein [OS=Homo sapiens]",24,8,18,8,531,57.3,5.43,53.91,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZGPAT","ENSG00000197114","","","",786.6,830.5,792.8,710.7,775.6,706.9,1.0988053985044681,0.13593590360111724,0.050873146336894486,1.2935114018517238,0.15492103221469272,0.8098896180398681,2564]
["High","Q8N5D0-1","WD and tetratricopeptide repeats protein 1 [OS=Homo sapiens]",4,2,2,2,677,75.9,7.27,4.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","WDTC1","ENSCATG00000044454; ENSCSAG00000000989; ENSG00000142784; ENSMFAG00000040733; ENSMNEG00000041566; ENSPANG00000008666; ENSPPAG00000030849; ENSPPYG00000001668","","Neddylation","",67.2,68.5,60.6,56.3,67.2,78.1,0.9737103174603172,-0.03843546603374576,0.806500911957816,0.09339513719253573,0.8891780740704077,0.05101125495599259,7082]
["High","Q8N5N7","39S ribosomal protein L50, mitochondrial [OS=Homo sapiens]",21,2,2,2,158,18.3,7.88,4.88,"","other membranes;mitochondrion;translational apparatus","","MRPL50","ENSG00000136897","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",31.4,26.9,32.8,34.9,25.9,20.6,1.119164619164619,0.16242225953580344,0.5154668393175249,0.2877992682362148,0.6810093200323578,0.1668469444588348,5910]
["High","Q8N653","Leucine-zipper-like transcriptional regulator 1 [OS=Homo sapiens]",1,1,1,1,840,94.7,6.57,2.7,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LZTR1","ENSG00000099949","22q11.2 copy number variation syndrome","","",31.1,26.2,25.1,28.8,26.1,33.9,0.9279279279279279,-0.10791533916688766,0.5079596828964011,0.294170756594961,0.6753191220934956,0.17049095277928275,5873]
["High","Q8N6G5-1","chondroitin sulfate N-acetylgalactosaminyltransferase 2 [OS=Homo sapiens]",4,2,2,2,542,62.5,5.73,4.97,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CSGALNACT2","ENSG00000169826; ENSPPAG00000040591; ENSPTRG00000002443","","Chondroitin sulfate biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",74.6,86.8,75.3,59.1,65,70.9,1.2138461538461538,0.27958558209764167,0.05621900067086982,1.2501168785255217,0.1642806726190687,0.7844135276703942,2672]
["High","Q8N720-1","zinc finger protein 655 [OS=Homo sapiens]",13,6,6,6,491,57.4,7.14,15.03,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF655","ENSG00000197343; ENSPPAG00000041610; ENSPTRG00000048790","Retinoblastoma gene in cancer","Generic Transcription Pathway","",326.4,305.6,297,428.1,373.7,403.3,0.7708903825408681,-0.3754023654966075,0.006897799485861877,2.1612894344176605,0.05033459662206499,1.2981334074442348,1070]
["High","Q8N8A6","ATP-dependent RNA helicase DDX51 [OS=Homo sapiens]",22,9,22,9,666,72.4,8.16,67.05,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DDX51","ENSG00000185163; ENSG00000288503","","","",431.7,491.3,443.2,477.6,513.7,495.3,0.9190098210682094,-0.12184781582061117,0.12885005330814822,0.889915397435701,0.283317717890741,0.5477262650786812,3551]
["Low","Q8N8K9","Uncharacterized protein KIAA1958 [OS=Homo sapiens]",1,1,1,1,716,79.2,6.83,2.28,"","","","KIAA1958","ENSG00000165185","","","",63.6,63.4,64.2,63.5,56.4,57,1.0808366308648953,0.11214847529029005,0.10540065174101296,0.9771567036713806,0.2483308053089406,0.6049694030960632,3314]
["High","Q8N983","39S ribosomal protein L43, mitochondrial [OS=Homo sapiens]",10,2,5,2,215,23.4,8.65,3.24,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL43","ENSG00000055950","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",159.5,144.5,167.1,156.8,149.8,133.1,1.0714123265863087,0.09951379945527379,0.339962892006365,0.4685684849471053,0.5265681929747466,0.2785453777266205,5041]
["High","Q8N9N8","probable RNA-binding protein EIF1AD [OS=Homo sapiens]",27,4,8,4,165,19,5.21,14.52,"protein metabolism;other metabolic processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity","EIF1AD","ENSG00000175376","","","",130.9,115.1,133.2,172,141.2,133.1,0.8496526999775936,-0.2350548423535959,0.16404719586384106,0.7850311888150787,0.32986878838652356,0.4816587747024909,3883]
["Medium","Q8N9V7","Testis- and ovary-specific PAZ domain-containing protein 1 [OS=Homo sapiens]",1,1,6,1,1692,190.8,7.87,1.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol","","TOPAZ1","ENSG00000173769","","","",252.3,290.4,229.9,217.6,333.9,242.4,0.9731704244867113,-0.03923561872806989,0.8661885758780608,0.062387548458677895,0.923177777840008,0.03471465812856859,7326]
["High","Q8NB49-1","Phospholipid-transporting ATPase IG [OS=Homo sapiens]",18,14,19,14,1132,129.4,6.67,40.15,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","ATP11C","ENSG00000101974","Complement system in neuronal development and plasticity","Ion transport by P-type ATPases","",629.5,671.6,611.5,642.1,697.6,686.1,0.9441208411491755,-0.08295656817186142,0.19924414513506608,0.7006144316527653,0.3745962641980727,0.426436558104008,4153]
["High","Q8NB90-1","Spermatogenesis-associated protein 5 [OS=Homo sapiens]",19,11,21,10,893,97.8,5.66,36.87,"developmental processes;other biological processes","cytoskeleton;mitochondrion;other cell component","other molecular function","SPATA5","ENSG00000145375","","","Ribosome biogenesis in eukaryotes",608.6,639.6,607.4,614.9,598.4,608.2,1.0187208344770793,0.02675875621969152,0.3817698585020148,0.4181983630114717,0.5656279042094368,0.24746917356538287,5270]
["High","Q8NBJ7-1","Sulfatase-modifying factor 2 [OS=Homo sapiens]",25,7,25,7,301,33.8,8,50.27,"","ER/Golgi","other molecular function","SUMF2","ENSG00000129103","","Glycosphingolipid metabolism; The activation of arylsulfatases","",940.2,967.9,942,961.7,921.2,888,1.0285827709408495,0.04065789344585306,0.3170867798894777,0.49882186437699566,0.503931116909636,0.29762882385318207,4913]
["High","Q8NBN3-1","Transmembrane protein 87A [OS=Homo sapiens]",14,5,10,5,555,63.4,6.74,24.09,"transport","other membranes;cytosol;ER/Golgi","","TMEM87A","ENSG00000103978","","RHOA GTPase cycle","",209.2,216.5,204.3,228.6,225.7,230.9,0.9194395796847636,-0.12117332280935769,0.008784861268663778,2.056265092532889,0.05668776593861718,1.246510658190704,1210]
["High","Q8NBT2","kinetochore protein SPC24 [OS=Homo sapiens]",49,8,16,8,197,22.5,4.7,36.98,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","","SPC24","ENSG00000161888","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",503.3,523.8,548,590.9,533.3,533.5,0.9501719249562648,-0.07373951529578521,0.29942519443069676,0.5237116597649195,0.4862545586761398,0.31313631410096726,4808]
["High","Q8NC54","Keratinocyte-associated transmembrane protein 2 [OS=Homo sapiens]",5,1,1,1,265,29.2,5.08,2.85,"","other membranes","","KCT2","ENSG00000113583","","","",22.4,27.3,32.2,31.9,30.9,37.9,0.8133068520357498,-0.29812832636577596,0.1544956211329854,0.811083825266534,0.3166146482431365,0.4994689962835178,3810]
["High","Q8NC96","adaptin ear-binding coat-associated protein 1 [OS=Homo sapiens]",27,6,17,6,275,29.7,6.8,34.83,"transport","plasma membrane;other membranes;cytosol","","NECAP1","ENSG00000089818","","Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",707.6,715.9,726.4,911.2,894.2,878.3,0.8010955024779223,-0.3199538513317825,8.3814243369254187E-5,4.076682171214198,0.007980751368623619,2.097956218939279,82]
["High","Q8NCH0","Carbohydrate sulfotransferase 14 [OS=Homo sapiens]",12,4,7,4,376,43,9.48,6.95,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST14","ENSG00000169105","Proteoglycan biosynthesis; Metapathway biotransformation Phase I and II","Dermatan sulfate biosynthesis; Defective CHST14 causes EDS, musculocontractural type","Glycosaminoglycan biosynthesis",45.3,42.9,49.7,48,45.2,47,0.9835948644793153,-0.02386389249664271,0.7397627522997384,0.1309075395763561,0.8464342863359259,0.07240675307718726,6824]
["High","Q8ND30","Liprin-beta-2 [OS=Homo sapiens]",13,8,17,6,876,98.5,6.27,36.09,"cell organization and biogenesis","cytosol;other cell component","other molecular function","PPFIBP2","ENSG00000166387","Ectoderm differentiation","Receptor-type tyrosine-protein phosphatases","",108.3,106,103.8,106,89.2,94.8,1.096896551724138,0.13342747163721666,0.14054510465086756,0.8521842767740127,0.2986870378644458,0.5247836240851668,3674]
["High","Q8ND76","cyclin-Y [OS=Homo sapiens]",7,2,3,1,341,39.3,7.2,7.6,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","enzyme regulator activity;other molecular function","CCNY","ENSG00000108100","","","",104.8,96.2,95.7,67.6,67.7,71.2,1.4368038740920097,0.5228631451734593,6.9952430469114133E-4,3.1551971915225847,0.018390187781240512,1.7354138361811615,297]
["High","Q8NDX6","Zinc finger protein 740 [OS=Homo sapiens]",14,3,3,3,193,21.8,9.19,4.23,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF740","ENSG00000139651","","Generic Transcription Pathway","",170.4,178.2,188.3,208,217.9,205.1,0.8508716323296356,-0.23298660030937368,0.008351873850805257,2.0782160740057165,0.05535775129633909,1.256821559798164,1178]
["High","Q8NE62","Choline dehydrogenase, mitochondrial [OS=Homo sapiens]",5,4,6,4,594,65.3,8.28,8.09,"other metabolic processes","other membranes;mitochondrion","other molecular function","CHDH","ENSG00000016391","Methionine de novo and salvage pathway; One-carbon metabolism and related pathways","Choline catabolism","Glycine, serine and threonine metabolism; Metabolic pathways",311.4,320.3,293.2,344.8,368.3,343.6,0.8752720734361692,-0.19219655453139287,0.01785202519653389,1.7483125088633305,0.08351624489786497,1.0782290408839417,1669]
["Medium","Q8NEE8","Tetratricopeptide repeat protein 16 [OS=Homo sapiens]",1,1,2,1,873,98.2,9.01,0,"","","","TTC16","ENSG00000167094","","","",98.8,97,97.7,114.6,99.5,97.3,0.9425176621708413,-0.08540844108162253,0.33607198911753516,0.4735676835395551,0.5225109699382148,0.2819045872578233,5022]
["High","Q8NEN9","PDZ domain-containing protein 8 [OS=Homo sapiens]",9,7,10,7,1154,128.5,6.09,18.93,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PDZD8","ENSG00000165650","","","",201.9,216.5,235.9,171.7,191.7,175.9,1.2132393843871687,0.27886423685134687,0.029628192607512042,1.5282948407415256,0.11079354783498756,0.9554855304131148,2088]
["High","Q8NEY1","neuron navigator 1 [OS=Homo sapiens]",17,24,41,24,1877,202.3,8.07,87.32,"cell organization and biogenesis;developmental processes","cytoskeleton;other cell component","","NAV1","ENSG00000134369","","","",1363.8,1418.3,1374.7,2029.8,1783.8,1879.4,0.7301598454242052,-0.45371576383062745,2.2324883968564556E-3,2.651210789637315,0.02959468489415145,1.5287862797657812,589]
["High","Q8NF99-1","Zinc finger protein 397 [OS=Homo sapiens]",11,4,7,2,534,61.1,7.27,9.32,"other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF397","ENSG00000186812","","","",47.3,49.4,50.5,49.7,48.6,51.5,0.9826435246995994,-0.02525995240173833,0.5303438572067537,0.2754424570690442,0.6925781630825109,0.15953120583055888,5979]
["High","Q8NFH3","Nucleoporin Nup43 [OS=Homo sapiens]",20,5,11,5,380,42.1,5.63,29.01,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;nucleus;other cell component","","NUP43","ENSG00000120253","","Separation of Sister Chromatids; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Transport of Ribonucleoproteins into the Host Nucleus; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transport of Mature mRNA derived from an Intron-Containing Transcript; tRNA processing in the nucleus; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis",268.4,258,277.4,264.5,251.8,237.5,1.0663305916688777,0.09265478239438853,0.1576894868661716,0.8021972600522402,0.3214724578201221,0.49285622936222756,3830]
["High","Q8NFP7","Diphosphoinositol polyphosphate phosphohydrolase 3-alpha [OS=Homo sapiens]",27,4,6,1,164,18.5,5.68,15.96,"other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT10","ENSG00000122824","","Synthesis of pyrophosphates in the cytosol","",50.7,51.3,60,57.4,62.3,59.4,0.9045226130653267,-0.14477152421397407,0.16159395991728906,0.7915748763808367,0.3271261703485074,0.4852847105882432,3857]
["High","Q8NFY9","Kelch repeat and BTB domain-containing protein 8 [OS=Homo sapiens]",5,3,4,3,601,68.8,6.29,7.76,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","","KBTBD8","ENSG00000163376","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",208.2,208.5,219.5,183.9,199.4,193,1.103938920701024,0.1426603521528303,0.02673058535820706,1.5729915307662554,0.10467021588609865,0.9801768800832569,1994]
["High","Q8NG48-1","protein Lines homolog 1 [OS=Homo sapiens]",2,2,7,1,757,85.8,6.52,9.69,"other biological processes","","","LINS1","ENSG00000140471","","","",93.3,87.3,84.6,93.4,65.3,84.2,1.0918073281185674,0.12671828547672287,0.43916998675844365,0.3573673475893374,0.6196312353830734,0.20786669773563518,5534]
["High","Q8NHP6-1","motile sperm domain-containing protein 2 [OS=Homo sapiens]",20,7,12,7,518,59.7,5.96,23.2,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","MOSPD2","ENSG00000130150","","Neutrophil degranulation; RHOD GTPase cycle","",465.4,498.3,518.4,507.4,459.3,461.2,1.0379578401848868,0.05374784543814172,0.4584881543484203,0.33867188042487084,0.635857106421397,0.1966404706175817,5630]
["High","Q8NI36","WD repeat-containing protein 36 [OS=Homo sapiens]",15,13,37,13,951,105.3,7.53,67.35,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","WDR36","ENSG00000134987","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1440.3,1505.4,1455.5,1453,1615.3,1614,0.9399654016188626,-0.08932044004550876,0.1776929129018882,0.7503298932356721,0.3481621741375014,0.45821841430916793,3985]
["Medium","Q8TAD4-1","Zinc transporter 5 [OS=Homo sapiens]",1,1,1,1,765,84,7.31,2.25,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A5","ENSG00000145740","Zinc homeostasis","Insulin processing; Zinc efflux and compartmentalization by the SLC30 family","",72.4,55.5,75.2,50.5,69.4,57.8,1.1429375351716378,0.192746558267475,0.36303144099596085,0.44005576047424183,0.5476332092922068,0.26151022347625036,5176]
["High","Q8TAD7","Overexpressed in colon carcinoma 1 protein [OS=Homo sapiens]",19,1,1,1,63,6.4,6.57,2.01,"","","","OCC1","ENSG00000235162","","","",23.5,15.1,17.9,15.8,15,13.5,1.275395033860045,0.35094416874753165,0.18732479126255538,0.7274047426672475,0.35901619297448023,0.44488596267275743,4074]
["High","Q8TB52","F-box only protein 30 [OS=Homo sapiens]",5,3,4,3,745,82.3,5.4,12.41,"protein metabolism;other metabolic processes","cytosol","other molecular function","FBXO30","ENSG00000118496","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",124.9,130.8,132,163.7,138,148.4,0.8613641413019331,-0.21530482963437067,0.055593953458131964,1.2549724408382101,0.16324843497596628,0.7871509735111418,2659]
["Medium","Q8TBC5","Zinc finger and SCAN domain-containing protein 18 [OS=Homo sapiens]",1,1,1,1,510,54.8,4.82,2.35,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZSCAN18","ENSG00000121413","","","",132.3,154.4,158.2,135.2,141.5,126.2,1.1042442293373047,0.14305929302718837,0.20331429591551908,0.6918320831477932,0.3788730363981797,0.42150630145545315,4190]
["Medium","Q8TBF5-1","Phosphatidylinositol-glycan biosynthesis class X protein [OS=Homo sapiens]",7,1,1,1,258,28.8,6.33,0,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","","PIGX","ENSG00000163964","3q29 copy number variation syndrome","Synthesis of glycosylphosphatidylinositol (GPI)","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways",71.2,51.5,57.2,64.6,39,60.4,1.096951219512195,0.13349937174603616,0.6191810504969963,0.20818234333052382,0.7599128642377472,0.11923620344323296,6362]
["High","Q8TC12","Retinol dehydrogenase 11 [OS=Homo sapiens]",17,5,11,5,318,35.4,8.82,21.05,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","RDH11","ENSG00000072042","","RA biosynthesis pathway; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision)","Retinol metabolism; Metabolic pathways; Biosynthesis of cofactors",517.3,638.8,585.6,470.2,571,534,1.1057008633824275,0.14496113124438165,0.2928281746692033,0.5333871396536289,0.47953070214285637,0.31918358172717365,4768]
["High","Q8TCA0-1","Leucine-rich repeat-containing protein 20 [OS=Homo sapiens]",6,1,1,1,184,20.5,6.55,3.47,"","","","LRRC20","ENSG00000172731; ENSPTRG00000002588","","","",28.1,26.4,34.8,25.8,32.7,22.4,1.1038318912237328,0.14252047269124504,0.5194675458162773,0.28444158018223153,0.6836343498623787,0.16517612386105,5933]
["High","Q8TCG2","Phosphatidylinositol 4-kinase type 2-beta [OS=Homo sapiens]",17,8,10,7,481,54.7,5.97,18.49,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","kinase activity;other molecular function","PI4K2B","ENSG00000038210","","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane; Synthesis of PIPs at the early endosome membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",376,237,233.6,268.1,268.1,290.2,1.0244433688286543,0.03484023445336065,0.8940941508877556,0.04861674623980651,0.9397075151610709,0.02700729992986688,7429]
["High","Q8TCZ2","CD99 antigen-like protein 2 [OS=Homo sapiens]",8,2,3,2,262,28,5.14,6.32,"cell adhesion","plasma membrane;other membranes","","CD99L2","ENSG00000102181","","Cell surface interactions at the vascular wall","Cell adhesion molecules; Leukocyte transendothelial migration",155.8,158.4,158.4,185.2,174.1,209.7,0.8305799648506151,-0.26780902322009736,0.038209704389023165,1.4178263222360257,0.13039395623666647,0.884742537698377,2288]
["Medium","Q8TD31-1","Coiled-coil alpha-helical rod protein 1 [OS=Homo sapiens]",1,1,1,1,782,88.6,5.95,1.83,"transport;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CCHCR1","ENSG00000204536; ENSG00000206355; ENSG00000206457; ENSG00000234114","","","",35.7,33.2,29.2,76.4,70.9,71.6,0.44814984010963915,-1.1579469129617073,9.5940614267833572E-5,4.017997505254357,0.008512549047764143,2.0699403727458896,88]
["High","Q8TD55","pleckstrin homology domain-containing family O member 2 [OS=Homo sapiens]",19,7,12,7,490,53.3,5.43,28.78,"","non-structural extracellular;other cell component","","PLEKHO2","ENSG00000241839","","Neutrophil degranulation","",480.8,401,482.7,524.8,384.4,415.1,1.0303556595937475,0.043142414849494166,0.8035042222792697,0.09501183675033183,0.8880057986633457,0.051584198276273835,7065]
["High","Q8TDJ6-1","DmX-like protein 2 [OS=Homo sapiens]",2,4,5,3,3036,339.4,6.38,7.05,"other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","DMXL2","ENSG00000104093","","","Lysosome",33.1,29.9,34.9,43.9,33,36.9,0.8602811950790861,-0.217119792702887,0.2053475014259034,0.6875105770739974,0.38184169829327314,0.41811664705330165,4199]
["High","Q8TDY2-1","RB1-inducible coiled-coil protein 1 [OS=Homo sapiens]",17,23,35,23,1594,183,5.41,54.38,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RB1CC1","ENSG00000023287","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Malignant pleural mesothelioma; Alzheimer's disease","Macroautophagy","Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",1328.8,1350.9,1261,1308.3,1293.6,1268.5,1.0181634973129392,0.025969248862474006,0.47057108399047254,0.327374763197412,0.6464143250875457,0.1894890277942087,5684]
["High","Q8TE77","Protein phosphatase Slingshot homolog 3 [OS=Homo sapiens]",14,6,9,6,659,73,5.3,13.74,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SSH3","ENSG00000172830","Regulation of actin cytoskeleton","","Axon guidance; Regulation of actin cytoskeleton",260.4,263.2,257.5,322.9,317.1,280.7,0.8483762354730094,-0.23722388590647725,0.024976050856843873,1.6024762299597417,0.10088618990700308,0.9961682793296593,1933]
["High","Q8TEH3","DENN domain-containing protein 1A [OS=Homo sapiens]",16,11,18,11,1009,110.5,6.96,32.4,"transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DENND1A","ENSG00000119522","","RAB GEFs exchange GTP for GDP on RABs","",650.6,561.8,625.3,658.8,624.2,639,0.956139438085328,-0.06470706667612282,0.37619999818793504,0.42458121087753203,0.560139127736727,0.2517040892369434,5244]
["High","Q8TEU7","Rap guanine nucleotide exchange factor 6 [OS=Homo sapiens]",6,6,7,5,1601,179.3,6.4,13.78,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","RAPGEF6","ENSG00000158987","","","Rap1 signaling pathway; Tight junction",111,132.1,99.1,125.3,116.8,117.8,0.9508196721311476,-0.07275634243531408,0.5874380578571101,0.23103792062915096,0.7352863667438787,0.13354348639164054,6238]
["High","Q8TF09","Dynein light chain roadblock-type 2 [OS=Homo sapiens]",13,1,2,1,96,10.8,7.5,4.85,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DYNLRB2","ENSG00000168589","Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome","Intraflagellar transport","Salmonella infection",97.6,87.8,111.1,112.1,92.8,84.3,1.0252420470262795,0.035964552482248384,0.8303613035099005,0.08073289801163623,0.9037442232792449,0.04395446569294863,7174]
["High","Q8TF46","DIS3-like exonuclease 1 [OS=Homo sapiens]",4,3,3,3,1054,120.7,6.54,4.64,"RNA metabolism OR transcription;other metabolic processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","DIS3L","ENSG00000166938","","","RNA degradation",110.9,97,94.4,108.8,104.1,119.6,0.9091729323308271,-0.13737336164820707,0.21707101528202136,0.6633981624665801,0.3956327001218541,0.40270781996776267,4284]
["Medium","Q8WTW4","GATOR complex protein NPRL2 [OS=Homo sapiens]",2,1,1,1,380,43.6,6.52,0,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;kinase activity","NPRL2","ENSG00000114388","22q11.2 copy number variation syndrome","Amino acids regulate mTORC1","mTOR signaling pathway",22.8,21.8,28.8,32.8,27.7,29.3,0.8173719376391982,-0.2909353818979341,0.1085122101382248,0.9645213908725999,0.25367165771235306,0.595728053025529,3340]
["High","Q8WU90","Zinc finger CCCH domain-containing protein 15 [OS=Homo sapiens]",50,22,60,22,426,48.6,5.31,136.13,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","other molecular function","ZC3H15","ENSG00000065548","VEGFA-VEGFR2 signaling pathway","","",2839.4,2830.9,3066.4,3689.5,3288.6,3055.7,0.870726942932887,-0.19970772949488919,0.0972961575509524,1.011904310680974,0.23563535923009812,0.6277595391553916,3224]
["High","Q8WUD6-1","Cholinephosphotransferase 1 [OS=Homo sapiens]",4,1,1,1,406,45.1,6.92,2.1,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","CHPT1","ENSG00000111666","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids","Synthesis of PC","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways; Choline metabolism in cancer",10.8,11.4,16.6,13.7,11.3,17.3,0.9172576832151302,-0.12460101093282173,0.6693772049015398,0.1743290812731899,0.7957517076539622,0.09922242072593883,6568]
["High","Q8WUI4","histone deacetylase 7 [OS=Homo sapiens]",4,3,4,3,952,102.9,7.58,9.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","HDAC7","ENSG00000061273","MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling pathway; Ethanol effects on histone modifications; Gastrin signaling pathway","Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway","Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis",140.4,134.4,130.6,135.7,137.9,141.2,0.977338476374156,-0.033069805346327016,0.3922075838260614,0.40648401295796727,0.5757392018262619,0.23977419861991217,5319]
["High","Q8WUN7","Ubiquitin domain-containing protein 2 [OS=Homo sapiens]",12,2,2,2,234,26.2,5.67,5.68,"","other cell component","","UBTD2","ENSG00000168246","","","",51.7,52.7,43.8,48.2,46.4,44.3,1.06695464362851,0.09349884832444165,0.36438716707478697,0.43843692633884385,0.5486183957809365,0.2607296341135411,5186]
["High","Q8WUY8","N-acetyltransferase 14 [OS=Homo sapiens]",11,1,2,1,206,21.6,10.74,7.22,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus","nucleic acid binding activity;other molecular function","NAT14","ENSG00000090971","Metapathway biotransformation Phase I and II","","",17.4,16.7,13.5,14.7,17.3,16.1,0.9896049896049894,-0.015075320462098672,0.9119879275855818,0.040010910594464134,0.9512158347032089,0.021720928714231855,7486]
["High","Q8WV74","Nucleoside diphosphate-linked moiety X motif 8 [OS=Homo sapiens]",6,1,1,1,236,25.4,8.41,4.51,"other metabolic processes","mitochondrion","other molecular function","NUDT8","ENSG00000167799","","","",33.8,31.9,40.9,37,39.9,46.3,0.8652597402597402,-0.20879481793572569,0.22691255542226496,0.6441414732655696,0.4070142965166655,0.39039033576433246,4353]
["High","Q8WVD3-1","E3 ubiquitin-protein ligase RNF138 [OS=Homo sapiens]",8,2,2,2,245,28.2,6.93,2.4,"cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction","other cell component","nucleic acid binding activity;other molecular function","RNF138","ENSG00000134758; ENSGGOG00000027857; ENSPPYG00000009094; ENSPTRG00000009956","","Antigen processing: Ubiquitination & Proteasome degradation","",81.1,80.2,88.5,109.8,93.4,108.9,0.8003844921499519,-0.321234880311253,0.024945987760604218,1.6029992950726921,0.10092138468124236,0.9960167994218303,1930]
["Medium","Q8WVL7","ankyrin repeat domain-containing protein 49 [OS=Homo sapiens]",5,1,1,1,239,27.3,5.15,2.54,"other biological processes","nucleus","","ANKRD49","ENSG00000168876","","","",29.2,26.7,25.9,22,20.6,28.8,1.145658263305322,0.19617676891264907,0.271563865845061,0.5661280175583046,0.45560177578818994,0.3414145918503803,4654]
["High","Q8WVQ1","Soluble calcium-activated nucleotidase 1 [OS=Homo sapiens]",9,3,5,3,401,44.8,6.09,12.48,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","CANT1","ENSG00000171302","Proteoglycan biosynthesis","Neutrophil degranulation","Purine metabolism; Pyrimidine metabolism; Metabolic pathways",226.9,269.1,230.3,193.6,224.7,224.9,1.12919776119403,0.1752981735411643,0.17996295670713866,0.7448168801928098,0.3504116623364934,0.4554214481543567,4010]
["Medium","Q8WW35","Tctex1 domain-containing protein 2 [OS=Homo sapiens]",13,1,1,1,142,16.1,4.93,0,"cell organization and biogenesis;transport;other biological processes","cytoskeleton;other cell component","other molecular function","DYNLT2B","ENSG00000213123","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 3q29 copy number variation syndrome","Intraflagellar transport","",52.2,43.8,44.3,31.5,36.2,29.7,1.4404517453798769,0.526521331537557,0.012832921701904058,1.8916744555066476,0.06891296605809277,1.161699057371031,1454]
["High","Q8WWM7-1","ataxin-2-like protein [OS=Homo sapiens]",30,26,79,25,1075,113.3,8.59,155.2,"cell organization and biogenesis;other biological processes","other membranes;cytosol;nucleus;other cell component","","ATXN2L","ENSG00000168488","16p11.2 distal deletion syndrome","","Amyotrophic lateral sclerosis; Spinocerebellar ataxia; Pathways of neurodegeneration",3470.6,3482.4,3692.8,4245.8,3577,3617.5,0.9305525204758617,-0.10384051645487716,0.3104033560535453,0.5080735918350592,0.4971547495520168,0.30350840721097944,4875]
["High","Q8WX77","Insulin-like growth factor-binding protein-like 1 [OS=Homo sapiens]",3,1,4,1,278,29,7.93,5.24,"other biological processes","non-structural extracellular","other molecular function","IGFBPL1","ENSG00000137142","","","",182.7,186.8,204.1,246.3,226.6,220.3,0.8274668205424119,-0.27322663045826506,0.017494583370399188,1.7570963956841406,0.0822877752747451,1.0846646790655603,1660]
["High","Q8WXE1","ATR-interacting protein [OS=Homo sapiens]",8,3,17,3,791,85.8,6.32,5.94,"DNA metabolism;other metabolic processes;stress response;signal transduction","nucleus","other molecular function","ATRIP","ENSG00000164053","miRNA regulation of DNA damage response; ATR signaling; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Fanconi Anemia Pathway; Activation of ATR in response to replication stress; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA)","Fanconi anemia pathway",506.4,482.4,483.6,509.2,423.9,495.2,1.030875866414619,0.0438706201065671,0.621795445591627,0.20635246331834736,0.761804305535764,0.11815657713957786,6373]
["High","Q8WXF7","Atlastin-1 [OS=Homo sapiens]",9,4,5,3,558,63.5,6.18,6.09,"cell organization and biogenesis;developmental processes","other membranes;ER/Golgi;other cell component","other molecular function","ATL1","ENSG00000198513","","","",98.9,106.1,117.4,113.4,91.3,109.3,1.0267515923566877,0.038087184748977695,0.7627369143308316,0.11762523446583883,0.8611118894006843,0.06494041440908842,6916]
["High","Q8WXW3","Progesterone-induced-blocking factor 1 [OS=Homo sapiens]",11,8,9,8,757,89.8,6.02,21.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding","PIBF1","ENSG00000083535","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","","",310.8,307.9,338.3,416.7,382.2,409.1,0.7922185430463575,-0.3360296248390535,0.004214132058365345,2.3752918590172576,0.03912478372380097,1.4075480501565345,841]
["High","Q8WY22","BRI3-binding protein [OS=Homo sapiens]",10,2,3,2,251,27.8,9.44,9.3,"","other membranes;mitochondrion","","BRI3BP","ENSG00000184992","","","",179,179.7,161.7,139.8,138.7,142.1,1.2372800760817877,0.3071721119860158,0.005086881873193816,2.293548347372724,0.04331338458658377,1.3633778783841095,917]
["High","Q8WYL5-1","Protein phosphatase Slingshot homolog 1 [OS=Homo sapiens]",3,2,2,2,1049,115.4,6.25,0,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SSH1","ENSG00000084112","Regulation of actin cytoskeleton","","Axon guidance; Regulation of actin cytoskeleton",28,35.4,25.6,40.7,37.2,36.7,0.7766143106457243,-0.3647298029031447,0.05631224961061789,1.2493971227395697,0.16443008412853571,0.7840187210068998,2674]
["High","Q8WZA9","Immunity-related GTPase family Q protein [OS=Homo sapiens]",29,10,21,10,623,62.7,4.88,52.89,"","","other molecular function","IRGQ","ENSG00000167378","","","",410.9,381.7,393.3,361.6,339.8,330.9,1.1487939552455677,0.20012006308263197,0.014736820968706788,1.831596192505007,0.07413988281163827,1.1299481047685411,1552]
["High","Q92503-1","SEC14-like protein 1 [OS=Homo sapiens]",12,6,8,6,715,81.2,6.43,13.9,"stress response;transport;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding","SEC14L1","ENSG00000129657","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","",371.3,395.7,376,389.2,420.5,402.8,0.942680412371134,-0.08515934374737422,0.11985556452271444,0.9213417982143086,0.2703154961852554,0.5681290570950484,3462]
["High","Q92530","proteasome inhibitor PI31 subunit [OS=Homo sapiens]",9,1,7,1,271,29.8,5.74,13.62,"protein metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMF1","ENSG00000125818","","Regulation of expression of SLITs and ROBOs; Neddylation; Ub-specific processing proteases; Separation of Sister Chromatids; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; ER-Phagosome pathway; Downstream TCR signaling; UCH proteinases; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome",25.4,27.7,22.7,24.4,24,19.5,1.1163475699558172,0.15878627392635966,0.28482531138590444,0.5454214191546432,0.47067005953463326,0.32728342734128946,4725]
["High","Q92542-1","Nicastrin [OS=Homo sapiens]",19,10,31,10,709,78.4,5.99,46.36,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","NCSTN","ENSG00000162736; ENSGGOG00000003518","Alzheimer's disease and miRNA effects; Notch signaling; Inclusion body myositis; Alzheimer's disease; Notch signaling pathway","Neutrophil degranulation; Amyloid fiber formation; Degradation of the extracellular matrix; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; Nuclear signaling by ERBB4; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3","Notch signaling pathway; Alzheimer disease",997.5,1076.9,1061.9,1053.5,1139.7,1078.8,0.9585268948655257,-0.06110918250905046,0.2695339309819775,0.5693865547419655,0.45375613046728763,0.34317749438529865,4638]
["High","Q92574-1","Hamartin [OS=Homo sapiens]",21,18,32,18,1164,129.7,6.47,43.57,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TSC1","ENSG00000165699","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Glioblastoma signaling pathways; Nanoparticle triggered autophagic cell death; Wnt signaling pathway; BDNF-TrkB signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; CAMKK2 pathway; Malignant pleural mesothelioma","TP53 Regulates Metabolic Genes; Macroautophagy; TBC/RABGAPs; Energy dependent regulation of mTOR by LKB1-AMPK; Inhibition of TSC complex formation by PKB","Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Cellular senescence; Thermogenesis; Insulin signaling pathway; Human cytomegalovirus infection; Human papillomavirus infection; Herpes simplex virus 1 infection; Choline metabolism in cancer",1114.5,1173.3,1203.8,1176.2,1158.6,1158.5,0.9995133541350586,-7.022524640115333E-4,0.984178053147281,0.006926323820637208,0.9920555433738665,3.4640118120657743E-3,7746]
["High","Q92581-1","Sodium/hydrogen exchanger 6 [OS=Homo sapiens]",2,1,1,1,669,74.1,6.48,3.74,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","SLC9A6","ENSG00000198689","","Sodium/Proton exchangers; Defective SLC9A6 causes  X-linked, syndromic mental retardation,, Christianson type (MRXSCH)","Cardiac muscle contraction",51.7,55.7,49.7,52.6,55.2,47.4,1.012242268041237,0.01755462310706858,0.8374242320110681,0.07705447636044374,0.9070062981748397,0.0423896972253709,7209]
["High","Q92613","protein jade-3 [OS=Homo sapiens]",4,3,7,3,823,93.7,7.18,2.9,"protein metabolism;other metabolic processes","nucleus","other molecular function","JADE3","ENSG00000102221","","HATs acetylate histones","",116.1,120.6,113.5,104.6,113.3,110,1.068008539188777,0.0949231820404969,0.0858091360157944,1.0664664707757832,0.217531731821858,0.6624773826175921,3080]
["High","Q92618","Zinc finger protein 516 [OS=Homo sapiens]",9,10,12,10,1163,124.2,8.72,24.97,"stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF516","ENSG00000101493","Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects","","Thermogenesis",615.2,627.1,620.8,642.1,618.4,656.4,0.971933851531118,-0.04106996553720309,0.19706396123811756,0.7053927915830046,0.37175052170747086,0.42974841332512914,4139]
["High","Q92665","28S ribosomal protein S31, mitochondrial [OS=Homo sapiens]",26,8,14,8,395,45.3,9.29,34.3,"","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS31","ENSG00000102738","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",477.5,484,496.8,606.4,502.7,563.2,0.8720325300484363,-0.1975461410041986,0.08017663433293327,1.0959521785833035,0.20832584388404093,0.6812568502634264,3005]
["High","Q92729-1","Receptor-type tyrosine-protein phosphatase U [OS=Homo sapiens]",1,1,1,1,1446,162.3,6.92,2.6,"cell adhesion;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PTPRU","ENSG00000060656","EPO receptor signaling","Signaling by SCF-KIT","",40.5,35.8,43.4,42.7,47.5,47.2,0.8711790393013099,-0.19895885187459839,0.0945650405892972,1.0242693866978705,0.23073869903788516,0.6368795603591412,3200]
["High","Q92738-1","USP6 N-terminal-like protein [OS=Homo sapiens]",4,2,2,2,828,94,9.07,7.22,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","USP6NL","ENSG00000148429","EGF/EGFR signaling pathway","Retrograde transport at the Trans-Golgi-Network","",93,107.5,109.3,101.5,120.4,117.2,{"$f":"AVERAGE(T5186:V5186)/AVERAGE(W5186:Y5186)","v":0.9135948097906221},{"$f":"LOG(Z5186,2)","v":-0.13037364023586256},{"$f":"TTEST(T5186:V5186,W5186:Y5186,2,2)","v":0.2783623494536619},{"$f":"-LOG10(AB5186)","v":0.5553895065984381},{"$f":"AB5186*7808/AF5186","v":0.4631266193339425},{"$f":"-LOG10(AD5186)","v":0.33430025615229736},4693]
["High","Q92793-1","CREB-binding protein [OS=Homo sapiens]",10,18,33,12,2442,265.2,8.53,61.8,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CREBBP","ENSG00000005339","Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL-6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RORA activates gene expression; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; SUMOylation of transcription cofactors; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; Formation of the beta-catenin:TCF transactivating complex; Estrogen-dependent gene expression; HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production","cAMP signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Cell cycle; Wnt signaling pathway; Notch signaling pathway; TGF-beta signaling pathway; Adherens junction; JAK-STAT signaling pathway; Long-term potentiation; Melanogenesis; Thyroid hormone signaling pathway; Glucagon signaling pathway; Growth hormone synthesis, secretion and action; Huntington disease; Tuberculosis; Hepatitis B; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Renal cell carcinoma; Prostate cancer",1045.8,992.9,1082.9,1195.9,1197.2,1255.1,0.855654843484458,-0.22489913939783515,0.005753586236400979,2.2400613731910903,0.046409092287002934,1.3333969258408487,968]
["High","Q92802-1","NEDD4-binding protein 2-like 2 [OS=Homo sapiens]",4,3,3,3,583,67.4,6.39,2.14,"developmental processes;other biological processes","nucleus;other cell component","other molecular function","N4BP2L2","ENSG00000244754","","","",165.4,159.7,161.2,273.1,266,268.9,0.6018564356435644,-0.7325087014004593,2.3151991721186658E-6,5.635411641522359,0.006025691711967513,2.2199930915833868,3]
["High","Q92834","X-linked retinitis pigmentosa GTPase regulator [OS=Homo sapiens]",3,2,2,1,1020,113.3,4.86,2.16,"cell organization and biogenesis;transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity","RPGR","ENSG00000156313","Ciliary landscape","","",23.9,21.6,25.8,22.3,24,18.2,1.1054263565891473,0.1446029161332717,0.34250590676957504,0.46533193437502385,0.529142485171516,0.27642736730028444,5054]
["High","Q92882","osteoclast-stimulating factor 1 [OS=Homo sapiens]",21,3,6,3,214,23.8,5.68,13.39,"signal transduction;other biological processes","other cell component","other molecular function","OSTF1","ENSG00000134996","","Neutrophil degranulation","",176,168.3,201.3,145.3,131.7,140.7,1.3062006224563085,0.3853765008613799,0.016534435098760087,1.7816106382272783,0.07969189459945603,1.0985858481112738,1620]
["High","Q92888-1","Rho guanine nucleotide exchange factor 1 [OS=Homo sapiens]",18,13,24,13,912,102.4,5.66,48.85,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","ARHGEF1","ENSG00000076928","G protein signaling pathways; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway","G alpha (12/13) signalling events; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK","Vascular smooth muscle contraction; Platelet activation; Regulation of actin cytoskeleton; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis",896.5,813.9,829.1,884,874.6,878.6,0.9629531321098135,-0.05446251251768609,0.2710988034300383,0.5668723992947576,0.4552127864906966,0.3417855475260761,4650]
["High","Q92922","SWI/SNF complex subunit SMARCC1 [OS=Homo sapiens]",47,52,215,42,1105,122.8,5.76,457.93,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","SMARCC1","ENSG00000173473","Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",10166.6,9651.6,10171.6,10931.7,10419,10833.6,0.931814580401003,-0.1018851899532811,0.03501753315049452,1.455714451538206,0.12338307709343918,0.9087444029359626,2216]
["High","Q92993-1","Histone acetyltransferase KAT5 [OS=Homo sapiens]",7,4,4,4,513,58.5,8.48,8.03,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","HTATIP; KAT5","ENSANAG00000035412; ENSCANG00000040731; ENSCCAG00000033565; ENSG00000172977; ENSGGOG00000003283; ENSMLEG00000035009; ENSMNEG00000035393; ENSPANG00000021813; ENSPPAG00000042045; ENSPPYG00000003052; ENSPTRG00000003890; ENSRBIG00000038205; ENSRROG00000042827; ENSSBOG00000020725","Androgen receptor signaling pathway; ATM signaling in development and disease ; Joubert syndrome; Gastrin signaling pathway; Androgen receptor signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex; Estrogen-dependent gene expression; DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; HDR through Single Strand Annealing (SSA); Sensing of DNA Double Strand Breaks","Spinocerebellar ataxia; Human T-cell leukemia virus 1 infection",88.7,80.7,89.1,117.4,109.6,105.9,0.7765094623009914,-0.364924589937966,0.004700663111014351,2.327840872885396,0.041613126497505724,1.3807696533585805,882]
["High","Q92995","Ubiquitin carboxyl-terminal hydrolase 13 [OS=Homo sapiens]",22,14,33,13,863,97.3,5.53,55.16,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","USP13","ENSG00000058056","","Ub-specific processing proteases; Regulation of PTEN stability and activity","",703.3,679.9,683.8,784.4,796.4,836.4,0.8551216283302996,-0.22579845838686138,2.5180754721209537E-3,2.5989312572962806,0.031109388111266466,1.5071085309200303,632]
["High","Q93073-1","Selenocysteine insertion sequence-binding protein 2-like [OS=Homo sapiens]",2,2,2,2,1101,121.7,6.04,5.06,"protein metabolism;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","KIAA0256; SECISBP2L","ENSG00000138593; ENSGGOG00000007289","Thyroid hormones production and peripheral downstream signaling effects","","",75.3,85.1,71.8,81.9,77.4,68,1.0215574131104266,0.030770288047718468,0.7890662524093561,0.10288653057026843,0.8781398658512333,0.05643630626961713,7016]
["High","Q969E2-1","Secretory carrier-associated membrane protein 4 [OS=Homo sapiens]",12,3,7,3,229,25.7,8.82,13.33,"transport","other membranes;ER/Golgi;other cytoplasmic organelle","","SCAMP4","ENSG00000227500; ENSPPAG00000030995; ENSPTRG00000042465","","","",292.8,280.7,313.4,298.2,269.2,299.2,1.0234248788368336,0.033405209926544874,0.647429401431876,0.18880758205781145,0.7801124639475444,0.1078427832697694,6480]
["High","Q969E8","pre-rRNA-processing protein TSR2 homolog [OS=Homo sapiens]",11,2,3,2,191,20.9,4.39,4.37,"RNA metabolism OR transcription;other metabolic processes","","","TSR2","ENSG00000158526","","","",77.9,84,79.9,73.6,70.5,73.7,1.1101928374655647,0.1508102905322167,0.018364629037614436,1.7360178399048132,0.08494728881853882,1.070850477535814,1688]
["High","Q969M3","Protein YIPF5 [OS=Homo sapiens]",5,1,2,1,257,28,4.36,5.15,"transport;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","","YIPF5","ENSG00000145817","","","",170.8,180.4,176.9,168.8,156.5,169.3,1.0677315002021834,0.09454890168150046,0.09099977907363746,1.0409596620439243,0.2249924873359599,0.6478319830575643,3158]
["High","Q969S9","Ribosome-releasing factor 2, mitochondrial [OS=Homo sapiens]",5,5,5,4,779,86.5,6.51,9.43,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","other molecular function","GFM2","ENSG00000164347","","Mitochondrial translation termination","",297.1,261.7,277.1,323.7,298.6,310.4,0.8962152889460706,-0.15808275659318072,0.06195206956681767,1.2079441810322917,0.1752615069484465,0.7563134584388741,2760]
["High","Q969V3","Nicalin [OS=Homo sapiens]",19,9,35,9,563,62.9,6.89,107.04,"protein metabolism;other biological processes","other membranes;ER/Golgi;other cell component","translation activity;other molecular function","NCLN","ENSG00000125912","","","",839.8,834.6,831.5,860.9,869.7,899.1,0.9529223865840212,-0.06956938028013136,0.02496405328123351,1.6026848991675444,0.10088992133533708,0.9961522165883836,1932]
["High","Q969Z3-1","Mitochondrial amidoxime reducing component 2 [OS=Homo sapiens]",7,2,7,1,335,38,9.16,17.82,"other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;other cytoplasmic organelle","other molecular function","MTARC2","ENSG00000117791","","Phase I - Functionalization of compounds","",121.9,115.5,123.2,88.5,94.3,98.1,1.2837308650765398,0.36034277230594336,1.928691801763529E-3,2.714737165558369,0.02868423921556121,1.5423566643056907,525]
["High","Q96A54","adiponectin receptor protein 1 [OS=Homo sapiens]",8,2,2,2,375,42.6,7.02,4.36,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","ADIPOR1","ENSG00000159346","AMP-activated protein kinase (AMPK) signaling; Leptin and adiponectin; Nonalcoholic fatty liver disease","AMPK inhibits chREBP transcriptional activation activity","AMPK signaling pathway; Longevity regulating pathway; Adipocytokine signaling pathway; Non-alcoholic fatty liver disease; Alcoholic liver disease",35.1,40.9,31.5,33,32.3,34.3,1.0793172690763055,0.11011901240874213,0.4002525719307164,0.3976658687235178,0.582619702019954,0.23461483324444365,5364]
["Medium","Q96A83","Collagen alpha-1(XXVI) chain [OS=Homo sapiens]",2,1,2,1,441,45.4,7.31,3.96,"other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","COL26A1","ENSG00000160963","","Collagen degradation; Collagen chain trimerization","Protein digestion and absorption",100.2,83.8,100.1,96.3,83.8,80.8,1.0889229589881182,0.12290188737208929,0.34487150984765985,0.4623426816169905,0.5312205067844799,0.2747251681817568,5069]
["Medium","Q96AG3","Solute carrier family 25 member 46 [OS=Homo sapiens]",3,1,1,1,418,46.1,7.43,2.43,"cell organization and biogenesis","other membranes;mitochondrion","","SLC25A46","ENSG00000164209","","","",91.5,99.6,90.1,97.6,111.2,97.9,0.9168568633844146,-0.12523157219448444,0.18885463690140067,0.7238723475800659,0.3611503808293256,0.4423119228444276,4083]
["Medium","Q96AN5-1","Transmembrane protein 143 [OS=Homo sapiens]",3,1,1,1,459,51.7,9.67,0,"","other membranes;mitochondrion","","TMEM143","ENSG00000161558","","","",30.5,20.3,27.3,17.9,22.6,21.1,1.2678571428571426,0.3423921974470776,0.1724749730782021,0.7632739141708398,0.34119194066242764,0.46700123590771975,3947]
["Medium","Q96AY2","crossover junction endonuclease EME1 [OS=Homo sapiens]",4,1,1,1,570,63.2,7.05,0,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EME1","ENSG00000154920","","Fanconi Anemia Pathway; Resolution of D-loop Structures through Holliday Junction Intermediates","Homologous recombination; Fanconi anemia pathway",16.7,18.1,12.1,17.3,22.3,18.2,0.8114186851211073,-0.3014815699853023,0.20117281469459758,0.696430707641034,0.37677076928170256,0.42392279810869593,4169]
["High","Q96B01","RAD51-associated protein 1 [OS=Homo sapiens]",13,4,8,4,352,38.4,9.11,14.53,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity","RAD51AP1","ENSG00000111247","","Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function","",390.2,360,400.1,793.7,739.3,709.5,0.512954292084727,-0.9630978178281044,1.8655835583732556E-4,3.7291852943970842,0.01103520941195332,1.9572194209442986,132]
["High","Q96BD8","Spindle and kinetochore-associated protein 1 [OS=Homo sapiens]",13,3,3,3,255,29.5,7.12,7.08,"cell cycle OR cell proliferation;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity","SKA1","ENSG00000154839; ENSG00000262634","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",175.5,163.5,204.2,201.7,169.8,174.6,0.9946896172862114,-0.007681677229531864,0.9536617414850631,0.020605639820428626,0.9746323138109126,0.011159193737483161,7640]
["High","Q96BN8","Ubiquitin thioesterase otulin [OS=Homo sapiens]",33,12,29,12,352,40.2,5.47,26.38,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","OTULIN","ENSG00000154124","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TNFR1 signaling","",1126.2,1049.6,1118.4,1230,1167.7,1127.1,0.9345778483885613,-0.09761325241898111,0.11707167508830976,0.9315481676163914,0.2662672994726253,0.5746821663835061,3433]
["High","Q96BR6-1","Zinc finger protein 669 [OS=Homo sapiens]",11,4,7,2,464,52.6,8.72,18.07,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF669","ENSG00000188295","","Generic Transcription Pathway","Herpes simplex virus 1 infection",184.9,189,214.4,141.4,125.3,170.4,1.3459162663006174,0.42858865812763614,0.035178013272543746,1.4537286915737098,0.12366948565151803,0.9077374454635484,2221]
["High","Q96BY7","autophagy-related protein 2 homolog B [OS=Homo sapiens]",2,4,6,4,2078,232.6,5.76,9.7,"cell organization and biogenesis;other metabolic processes;transport","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","ATG2B","ENSG00000066739","Alzheimer's disease and miRNA effects; Alzheimer's disease","","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",289,259.2,281.5,337.8,309,310.5,0.8667084508513528,-0.2063813231794517,0.030372750689890628,1.517515874682171,0.11260704529281387,0.9484344368730033,2106]
["High","Q96C36","Pyrroline-5-carboxylate reductase 2 [OS=Homo sapiens]",25,7,29,6,320,33.6,7.77,64.53,"other metabolic processes;stress response","mitochondrion","other molecular function","PYCR2","ENSG00000143811","Metabolic reprogramming in colon cancer","Glutamate and glutamine metabolism","Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids",1349.9,1362.6,1391.9,1252.2,1351.1,1367.5,1.0336456129747151,0.047741640160397544,0.30736093555631055,0.5123513305591488,0.49441165735963594,0.30591129789642935,4854]
["High","Q96C92-4","Isoform 4 of Serologically defined colon cancer antigen 3 [OS=Homo sapiens]",15,4,5,4,362,40,4.88,9.17,"","","","ENTR1","","","","",112.1,94.7,110.8,101.7,104.3,105.1,1.0208936033429765,0.0298325176085759,0.7226885758797774,0.1410488104702988,0.8336168415525635,0.07903351990892185,6769]
["Medium","Q96CN4","EVI5-like protein [OS=Homo sapiens]",1,1,1,1,794,91.3,5.34,1.95,"transport;other biological processes","","enzyme regulator activity;other molecular function","EVI5L","ENSG00000142459","","","",38,39.6,37.7,30.2,27.2,29.6,1.325287356321839,0.4063052069156811,0.00098010129260234,3.008729038037128,0.021139864344306827,1.6748978039116584,362]
["High","Q96CS7-1","Pleckstrin homology domain-containing family B member 2 [OS=Homo sapiens]",14,3,5,3,222,24.7,5.39,7.1,"other biological processes","other membranes;other cytoplasmic organelle","other molecular function","PLEKHB2","ENSG00000115762","","","",366.9,367.7,357.1,413.4,427.2,403.3,0.8776428973390143,-0.1882940515234597,0.002774334713258392,2.556841144073129,0.03228316757246129,1.4910238595834857,671]
["High","Q96CW6","Probable RNA polymerase II nuclear localization protein SLC7A6OS [OS=Homo sapiens]",42,7,10,7,309,35,4.6,22.52,"transport;developmental processes;other biological processes","nucleus;other cell component","","SLC7A6OS","ENSG00000103061","","","",317.3,305.5,316.5,312.9,349.2,337.2,0.9399579705794056,-0.08933184553568124,0.15244964234814634,0.816873590166483,0.31390474880124647,0.5032021141738763,3792]
["High","Q96D71","RalBP1-associated Eps domain-containing protein 1 [OS=Homo sapiens]",12,8,9,8,796,86.6,5.69,18.76,"transport","plasma membrane;other membranes;cytosol","other molecular function","REPS1","ENSG00000135597","","Cargo recognition for clathrin-mediated endocytosis","",449.6,451,427.9,461.1,468.4,414.2,0.9886879511795786,-0.016412844198984883,0.7983207879902949,0.09782256170736595,0.8846563600096825,0.053225395893954225,7046]
["High","Q96DE0","U8 snoRNA-decapping enzyme [OS=Homo sapiens]",25,5,13,4,195,21.3,6.89,32.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT16","ENSG00000198585","","Phosphate bond hydrolysis by NUDT proteins","Purine metabolism; Metabolic pathways; RNA degradation",513.4,485.2,504.8,520.1,482,515.3,0.9907736918413074,-0.013372533886840888,0.7652438483485962,0.11620015292827246,0.8629439583919466,0.06401740747299335,6924]
["High","Q96DM3","Uncharacterized protein C18orf8 [OS=Homo sapiens]",6,3,4,3,657,74.9,7.83,7.57,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle","","RMC1","ENSG00000141452","","","",84.8,70.8,80.5,81.5,78.9,68,1.0337127845884413,0.047835390865799736,0.6835963637951272,0.1652002560564958,0.8051773130958445,0.09410847041539068,6629]
["High","Q96DU9-1","Polyadenylate-binding protein 5 [OS=Homo sapiens]",5,2,14,1,382,43.3,9.51,32.73,"","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity","PABPC5","ENSANAG00000005063; ENSCCAG00000032154; ENSG00000174740; ENSGGOG00000007622; ENSNLEG00000035086; ENSPPYG00000020526; ENSPTRG00000022078","","","mRNA surveillance pathway; RNA degradation",85.3,76.4,96,78.3,70,79.9,1.1292725679228743,0.17539374557093765,0.20168462691474043,0.695327203921802,0.37736725783615943,0.4232357839748755,4173]
["High","Q96DZ1","Endoplasmic reticulum lectin 1 [OS=Homo sapiens]",10,4,8,4,483,54.8,6.28,15.24,"protein metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi","other molecular function","ERLEC1","ENSG00000068912","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis","Protein processing in endoplasmic reticulum",165.9,178.9,180.1,147.6,168.4,161.7,1.0988067824994767,0.13593772073951205,0.10826470734864736,0.9655130937136756,0.2534725142363534,0.5960691273076079,3335]
["High","Q96E52-1","Metalloendopeptidase OMA1, mitochondrial [OS=Homo sapiens]",6,3,4,3,524,60.1,9.25,7.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion","other molecular function","OMA1","ENSG00000162600","","Regulation of Apoptosis","Spinocerebellar ataxia",175.2,190.5,154.5,181.1,184.7,213.5,0.8979803210771622,-0.15524426572881517,0.24926665082450108,0.6033358215030876,0.43212122771707473,0.36439439868774204,4504]
["High","Q96ED9-1","Protein Hook homolog 2 [OS=Homo sapiens]",13,8,8,8,719,83.2,5.47,19.23,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","HOOK2","ENSG00000095066","","","",287.7,280.9,300.5,311.8,295.8,306.8,0.9504593175853018,-0.07330321822291878,0.11225140047628035,0.9498082319252946,0.25869508114486334,0.5872118289253285,3388]
["High","Q96EK5","KIF1-binding protein [OS=Homo sapiens]",16,8,19,8,621,71.8,5.49,37.08,"transport;developmental processes;other biological processes","cytoskeleton;mitochondrion","cytoskeletal activity","KIFBP","ENSG00000198954","","","",827.8,832.6,850.9,766.6,773.7,827.3,1.0606943740496704,0.08500902141728377,0.07879852866606658,1.1034818916243272,0.20611688838346662,0.6858864224310798,2985]
["High","Q96EP0-1","E3 ubiquitin-protein ligase RNF31 [OS=Homo sapiens]",18,12,18,12,1072,119.6,6.57,29.82,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RNF31","ENSG00000092098; ENSG00000285152","","Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway","Necroptosis; NOD-like receptor signaling pathway; Shigellosis",571.3,526.4,518.3,507.3,481,486.9,1.0954446854663775,0.1315166372098192,0.06240345620918822,1.2047913562949597,0.17609186341935004,0.7542607107772762,2767]
["High","Q96ES7","SAGA-associated factor 29 [OS=Homo sapiens]",29,5,6,5,293,33.2,8.1,10.71,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SGF29","ENSG00000176476","","HATs acetylate histones","",122.5,115.8,136.5,107.8,98.7,110.1,1.1838281743524952,0.24345969752200564,0.05069749031205386,1.2950135391006623,0.15474824251623007,0.810374274584662,2558]
["High","Q96EX3","Wd repeat-containing protein 34 [OS=Homo sapiens]",8,3,3,3,536,57.8,6.64,3.04,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","DYNC2I2","ENSG00000119333","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 3q29 copy number variation syndrome","Intraflagellar transport","",61.4,70,76.6,73.5,76,73.3,0.9335727109515259,-0.0991657043115774,0.33313684734674254,0.4773773285386978,0.5205388241111398,0.2835468733226492,4997]
["High","Q96F44-1","E3 ubiquitin-protein ligase TRIM11 [OS=Homo sapiens]",17,6,10,6,468,52.7,5.69,23.99,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM11","ENSG00000154370; ENSPPAG00000018913; ENSPTRG00000002071","","Antigen processing: Ubiquitination & Proteasome degradation","",443.6,437.1,430.8,412.1,380.6,375,1.1231480688533013,0.16754813621465114,0.016766975407825277,1.775545272645026,0.08031689814987715,1.0951930723903485,1630]
["High","Q96F46","Interleukin-17 receptor A [OS=Homo sapiens]",4,2,2,2,866,96.1,5.21,2.5,"stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","IL17RA","ENSG00000177663","IL-17 signaling pathway","Interleukin-17 signaling","Cytokine-cytokine receptor interaction; IL-17 signaling pathway; Alcoholic liver disease",8.1,16.8,8.4,14.6,8.2,13.1,0.9275766016713092,-0.10846166675178923,0.8137405019988032,0.08951406749113343,0.8931242394724003,0.049088123682259545,7114]
["High","Q96FL9","Polypeptide N-acetylgalactosaminyltransferase 14 [OS=Homo sapiens]",8,3,5,3,552,64.3,7.72,6.62,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT14","ENSG00000158089","","O-linked glycosylation of mucins","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways",107.1,94.1,118.9,127.1,128,119.5,0.8545114789108382,-0.2268282226974643,0.07649164548556037,1.1163859964497513,0.201908981727943,0.6948443614519896,2958]
["High","Q96FW1","Ubiquitin thioesterase otub1 [OS=Homo sapiens]",50,10,66,10,271,31.3,4.94,168.33,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","OTUB1","ENSG00000167770","","Ub-specific processing proteases; Ovarian tumor domain proteases","",2476.3,2653.4,2452.8,2256.9,2628.6,2393,1.0417668475647457,0.05903243164744017,0.46530773876537174,0.3322597244382583,0.6421213899399121,0.1923828629005949,5658]
["High","Q96G21","U3 small nucleolar ribonucleoprotein protein IMP4 [OS=Homo sapiens]",34,8,17,8,291,33.7,9.47,36.47,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","IMP4","ENSG00000136718","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",448.2,453.2,464,414.3,441.9,444.2,1.0499846201168872,0.07036819584987333,0.11232754932900832,0.9495137160961031,0.2587178481300581,0.5871736096405499,3390]
["High","Q96G97-4","Isoform 3 of Seipin [OS=Homo sapiens]",15,6,13,6,462,51.1,5.27,25.3,"","","","BSCL2","","","","",1014.3,1157.6,1083.2,1091.8,1123.7,1127.9,0.9735897589280371,-0.03861410228913189,0.5305241387325953,0.2752948510088831,0.69269773833179,0.15945623033865852,5980]
["High","Q96GM5","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [OS=Homo sapiens]",57,22,71,21,515,58.2,9.25,144.54,"cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SMARCD1","ENSG00000066117","Tumor suppressor activity of SMARCB1; Thermogenesis","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Thermogenesis; Hepatocellular carcinoma",2147.4,2078.8,2137.8,2191.5,2277.6,2230.2,{"$f":"AVERAGE(T5506:V5506)/AVERAGE(W5506:Y5506)","v":0.9499499947755736},{"$f":"LOG(Z5506,2)","v":-0.07407652269435029},{"$f":"TTEST(T5506:V5506,W5506:Y5506,2,2)","v":0.02724635975104074},{"$f":"-LOG10(AB5506)","v":1.5646915134108903},{"$f":"AB5506*7808/AF5506","v":0.10573537621079826},{"$f":"-LOG10(AD5506)","v":0.9757796851361445},2012]
["High","Q96GQ5-1","RUS1 family protein C16orf58 [OS=Homo sapiens]",5,2,5,2,468,51,6.93,16.07,"","other membranes","","C16orf58; RUSF1","ENSG00000140688","","","",194.2,192.8,167.2,164.1,151.3,149,1.1933677863910424,0.25503873861585064,0.039660276834644834,1.401644258679908,0.13370787630609104,0.8738430090766713,2316]
["Medium","Q96GX2","Ataxin-7-like protein 3B [OS=Homo sapiens]",10,1,1,1,97,10.8,4.36,2.57,"other biological processes","other cell component","","ATXN7L3B","ENSG00000253719","","","",126,98.2,123.9,126.8,125.6,107.1,0.9682892906815023,-0.04648995660297737,0.746685186574001,0.12686246451878436,0.8512363756416702,0.06994982607004668,6849]
["High","Q96H22","Centromere protein N [OS=Homo sapiens]",9,2,3,2,339,39.5,9.13,6.1,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","","CENPN","ENSG00000166451","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere","",107.4,109,90.4,97.5,97.4,87.5,1.0864022662889519,0.11955839423175317,0.2985245438226764,0.5250199566332554,0.48529661423432385,0.3139927386135821,4803]
["High","Q96HB5-1","Coiled-coil domain-containing protein 120 [OS=Homo sapiens]",1,1,1,1,630,67.5,9.38,2.12,"cell organization and biogenesis;other biological processes","cytoskeleton;other cytoplasmic organelle;other cell component","","CCDC120","ENSG00000147144","","","",27.1,21.2,23.3,26.2,23.8,29,0.9063291139240506,-0.14189306580020894,0.3418308214905846,0.4661887812881779,0.5287272294371007,0.2767683228656204,5048]
["High","Q96HP0","Dedicator of cytokinesis protein 6 [OS=Homo sapiens]",14,23,38,20,2047,229.4,6.74,59.64,"signal transduction","cytosol;other cell component","enzyme regulator activity","DOCK6","ENSG00000130158","","CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production","",907,804.4,870.1,783.6,768.7,798.6,1.0980900931558126,0.1349964255789611,0.0695423309421488,1.1577507565870844,0.18912801114465266,0.7232441444249549,2871]
["High","Q96I27","Zinc finger protein 625 [OS=Homo sapiens]",21,2,3,1,306,34.7,8.98,9.54,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF625","ENSG00000257591","","Generic Transcription Pathway","",34.2,27.7,37.9,28.9,25.3,26.8,1.232098765432099,0.3011179075652737,0.11827278563809267,0.9271151742805369,0.26821780722109423,0.571512392326575,3443]
["High","Q96II8-1","Leucine-rich repeat and calponin homology domain-containing protein 3 [OS=Homo sapiens]",19,11,15,11,777,86,6.71,30.21,"cell organization and biogenesis","cytosol;other cell component","","LRCH3","ENSG00000186001","","","",490.1,498.2,526.2,566.5,479.8,549.4,0.9491132418374382,-0.07534786465826616,0.3987432798740099,0.39930662315288984,0.5813982314204051,0.23552629366212885,5355]
["High","Q96IY1","Kinetochore-associated protein NSL1 homolog [OS=Homo sapiens]",22,5,8,5,281,32.1,6.79,9.22,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","","NSL1","ENSG00000117697","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",292.2,265.5,272.1,263.6,235.8,254.9,1.1000928012727031,0.13762523128510704,0.0935361772528869,1.029020383325333,0.22923115881686784,0.6397263501318105,3186]
["High","Q96JA1","Leucine-rich repeats and immunoglobulin-like domains protein 1 [OS=Homo sapiens]",2,2,2,2,1093,119,7.09,2.24,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","","LRIG1","ENSG00000144749","","Signaling by EGFR; Negative regulation of MET activity","",89.8,78.7,88.5,90.1,77.5,87.6,1.0070532915360502,0.010140030316371092,0.9138098478971153,0.03914416597353991,0.9527343159808621,0.021028191901406357,7489]
["High","Q96JC9","ELL-associated factor 1 [OS=Homo sapiens]",18,3,4,3,268,29,5.4,9.02,"other biological processes","non-structural extracellular;nucleus;other cell component","other molecular function","EAF1","ENSG00000144597","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",83.6,99.9,91.2,87,66.3,84.5,1.1551724137931034,0.2081081953302003,0.2010387503052428,0.696720224063431,0.37661001976567554,0.4241081296962637,4168]
["High","Q96JJ7-1","Protein disulfide-isomerase TMX3 [OS=Homo sapiens]",24,9,19,9,454,51.8,4.91,47.36,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TMX3","ENSG00000166479; ENSGGOG00000005485","","Platelet degranulation","",643.8,638,634.6,617.6,656.6,617.3,1.0131641554321968,0.01886794219565068,0.5670772711731047,0.24635775917126856,0.7198405679271015,0.14276368153638094,6151]
["High","Q96JM7","Lethal(3)malignant brain tumor-like protein 3 [OS=Homo sapiens]",11,7,9,6,780,88.3,6.46,13.67,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","other molecular function","L3MBTL3","ENSG00000198945","","","",307.7,309.2,310.6,390.7,390.6,411,0.7779082445693198,-0.3623280976597382,2.0735922750014544E-4,3.683276633735084,0.0116479197720945,1.9337516293305441,139]
["High","Q96JP5-1","E3 ubiquitin-protein ligase ZFP91 [OS=Homo sapiens]",13,5,6,5,570,63.4,7.36,12.7,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","other molecular function","ZFP91","ENSG00000186660","","","",135.7,154.7,165.1,217.4,242.3,225.8,0.6644784828592268,-0.5897056119771752,2.459721452954841E-3,2.6091140710649174,0.03097662113656677,1.5089659559045356,620]
["High","Q96K31-1","Uncharacterized protein C8orf76 [OS=Homo sapiens]",4,2,2,2,380,43.2,5.43,4.94,"","","","C8orf76","ENSG00000189376","","","",161.1,157.7,173.2,137.8,158.5,147.4,1.1088573360378633,0.14907376240637818,0.10180197853364759,0.9922437813519577,0.24300515083788454,0.614384520818304,3271]
["High","Q96KM6","zinc finger protein 512B [OS=Homo sapiens]",7,5,7,5,892,97.2,9.83,9.47,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512B","ENSG00000196700","","RHOV GTPase cycle","",173.2,160.8,174.9,183.5,179.3,185.1,0.9288191275780252,-0.10653041232878106,0.0526485388826051,1.2786136769766354,0.1577435884863318,0.8020482836945659,2606]
["High","Q96KR1","Zinc finger RNA-binding protein [OS=Homo sapiens]",34,26,83,26,1074,116.9,9.04,188.67,"","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZFR","ENSG00000056097","Exercise-induced circadian regulation","","",3035.3,3004.5,3070,3220.7,3190.7,3241.6,0.9437273386511965,-0.08355799800791257,1.6543172322706324E-3,2.7813812063831365,0.02663280195787443,1.5745831403267645,485]
["High","Q96L73-1","Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [OS=Homo sapiens]",4,8,9,8,2696,296.5,8.03,12.95,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD1","ENSG00000165671","Histone modifications; Pathways affected in adenoid cystic carcinoma","PKMTs methylate histone lysines","Lysine degradation; Metabolic pathways",314.9,312.6,312.6,401.4,397.5,405.9,0.7802954847277558,-0.3579075431868815,4.1311154725475377E-6,5.383932665495619,0.004031968701206397,2.3944828478289275,8]
["High","Q96LR4","Protein FAM19A4 [OS=Homo sapiens]",8,1,1,1,140,15.7,8.9,4.32,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","TAFA4","ENSG00000163377","","","",74.5,72.7,82.7,70.6,71.9,70.8,1.077824660103141,0.1081225003776083,0.14921747411077482,0.8261803158344042,0.30961733666142166,0.5091747294956331,3763]
["High","Q96LR5","Ubiquitin-conjugating enzyme E2 E2 [OS=Homo sapiens]",34,6,26,3,201,22.2,7.71,57.57,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","UBE2E2","ENSG00000182247","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",840.9,843.5,857.5,968.6,1052.3,1051.1,0.8274414062500001,-0.2732709411614685,3.3004126711686705E-3,2.4814317541807855,0.035300852241760244,1.452214809642606,730]
["High","Q96ME7","Zinc finger protein 512 [OS=Homo sapiens]",20,13,35,13,567,64.6,9.76,77.31,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512","ENSG00000243943","","","",844.2,845.6,837.6,1019.9,1016.9,1040.7,0.8212510154346061,-0.28410484563313804,2.0210164076617278E-5,4.694430160642032,0.004508598888863648,2.3459584003336724,35]
["High","Q96MR9","Zinc finger protein 560 [OS=Homo sapiens]",2,2,4,1,790,91.1,8.69,5.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF560","ENSG00000198028","","Generic Transcription Pathway","Herpes simplex virus 1 infection",64,73.9,70.3,68.8,67.4,59.9,1.0617032126466088,0.08638053310726808,0.37039776490675735,0.4313316426477451,0.5548859839585497,0.2557962450296568,5212]
["High","Q96MW5","Conserved oligomeric Golgi complex subunit 8 [OS=Homo sapiens]",11,6,10,6,612,68.4,5.2,24.18,"transport","other membranes;ER/Golgi","","COG8","ENSG00000213380","","COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",805.7,776.8,771.2,832,825.4,839.6,0.9426111333600319,-0.08526537348693995,0.014010577194573196,1.8535439726903447,0.07220764801005117,1.141416800870033,1515]
["High","Q96N21-1","AP-4 complex accessory subunit tepsin [OS=Homo sapiens]",4,1,3,1,525,55.1,7.03,2.75,"","other membranes;cytosol;ER/Golgi;nucleus;other cell component","","TEPSIN","ENSG00000167302","","","",29.5,28.9,28.4,35.5,37.2,30.9,0.8378378378378379,-0.2552570552420744,0.04263051059458245,1.370279465685458,0.13956353321698103,0.8552280444029554,2385]
["High","Q96N67","Dedicator of cytokinesis protein 7 [OS=Homo sapiens]",22,37,86,34,2140,242.4,6.8,150.9,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other cell component","enzyme regulator activity;other molecular function","DOCK7","ENSG00000116641","","CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production; MET activates RAP1 and RAC1","",2972.2,2944.5,2890,2905.6,2914.1,2922.7,1.007354959736457,0.010572132617083434,0.4335533381185981,0.36295746560273123,0.6150407819821972,0.21109608617155076,5504]
["High","Q96NT0","Coiled-coil domain-containing protein 115 [OS=Homo sapiens]",7,1,1,1,180,19.7,6.95,3.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","CCDC115","ENSG00000136710","","RHOA GTPase cycle","",80.8,51.8,52.6,41.2,36,40.1,1.5788576300085249,0.6588810852317277,0.07925506697710966,1.1009729626767286,0.20689520660557412,0.6842495710494115,2991]
["High","Q96P70","Importin-9 [OS=Homo sapiens]",29,23,79,23,1041,115.9,4.81,153.34,"transport","cytosol;nucleus;other cell component","other molecular function","IPO9","ENSG00000198700","","","Nucleocytoplasmic transport",2915.8,2984.8,2858.2,2852.7,3128.2,3065.9,0.9681655391961799,-0.046674350942226266,0.35136253649170746,0.4542445463759715,0.5372970397429009,0.2697855521855676,5106]
["High","Q96PK6-1","RNA-binding protein 14 [OS=Homo sapiens]",46,28,138,28,669,69.4,9.67,261.35,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RBM14","ENSCATG00000036313; ENSG00000239306; ENSGGOG00000014455; ENSMFAG00000003827; ENSMLEG00000024601; ENSMMUG00000020363; ENSPANG00000004924; ENSPPYG00000003015; ENSRBIG00000043267; ENSRROG00000044302","Ciliary landscape","RUNX2 regulates bone development","",5250.6,5291.6,5158.7,4797.6,4783.3,4859.1,1.087319944598338,0.12077651678495233,7.7359108143985683E-4,3.1114885457810315,0.018994336993340886,1.7213758611068288,318]
["High","Q96PV7-1","Protein FAM193B [OS=Homo sapiens]",8,6,7,6,902,96.5,7.9,7.56,"","nucleus;other cell component","","FAM193B","ENSG00000146067","","","",278.9,279.2,274.2,291.9,254.3,242.4,1.0554146588891706,0.07780992669544338,0.38663176464486104,0.4127024683538232,0.5706655611242109,0.24361833573037348,5290]
["High","Q96Q05","Trafficking protein particle complex subunit 9 [OS=Homo sapiens]",5,5,5,5,1148,128.4,6.62,2.54,"developmental processes;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC9","ENSG00000167632","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",138.3,158.5,127.6,128.1,128.5,113.9,1.1454790823211876,0.19595111372156856,0.15460014914783504,0.8107900914393594,0.316745726724297,0.4992892355528913,3811]
["High","Q96QC0","Serine/threonine-protein phosphatase 1 regulatory subunit 10 [OS=Homo sapiens]",27,22,38,22,940,99,9.17,64.22,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","PPP1R10","ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104","","","",2344,2185.4,2406,2230.5,1991,2143.6,{"$f":"AVERAGE(T5698:V5698)/AVERAGE(W5698:Y5698)","v":1.089597963896875},{"$f":"LOG(Z5698,2)","v":0.12379591253877276},{"$f":"TTEST(T5698:V5698,W5698:Y5698,2,2)","v":0.11875133040256435},{"$f":"-LOG10(AB5698)","v":0.9253615161598887},{"$f":"AB5698*7808/AF5698","v":0.26875663414006445},{"$f":"-LOG10(AD5698)","v":0.5706408065745274},3450]
["High","Q96QU8","Exportin-6 [OS=Homo sapiens]",6,6,11,6,1125,128.8,6.35,18.38,"transport","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","XPO6","ENSG00000169180","","","Nucleocytoplasmic transport",414.8,361.8,371.4,416.2,380.9,703.9,0.7648234510326449,-0.3868013349450006,0.3194161286005396,0.4956431583748434,0.506396168956957,0.29550958854983844,4925]
["High","Q96RL1","BRCA1-A complex subunit RAP80 [OS=Homo sapiens]",13,8,8,8,719,79.7,5.45,16.69,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","UIMC1","ENSG00000087206","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","Homologous recombination",476.9,468,473.6,590,531.6,583.3,0.8320136078362368,-0.2653209706107643,0.006870080921735047,2.163038147415556,0.05050997348108027,1.2966228595023708,1062]
["High","Q96RQ1","Endoplasmic reticulum-Golgi intermediate compartment protein 2 [OS=Homo sapiens]",13,4,9,4,377,42.5,6.77,16.2,"transport","other membranes;ER/Golgi;nucleus;other cell component","","ERGIC2","ENSG00000087502","","","",365.7,416.3,379,408.2,435.1,410.7,0.9258373205741627,-0.11116937593647244,0.1495199362045143,0.8253008969290727,0.30999778594924254,0.5086414079510834,3766]
["High","Q96RS6","NudC domain-containing protein 1 [OS=Homo sapiens]",29,12,33,12,583,66.7,5.11,51.84,"other biological processes","cytosol;nucleus","","NUDCD1","ENSG00000120526","","","",842.7,983.2,841.3,813.7,963.3,862.5,1.0104944118204204,0.01506134342842599,0.8930317629568236,0.04913309404364102,0.9388436791661342,0.027406713300603125,7427]
["High","Q96RW7-1","Hemicentin-1 [OS=Homo sapiens]",1,3,3,3,5635,613,6.49,4.34,"cell adhesion;cell cycle OR cell proliferation;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","HMCN1","ENSG00000143341","","","",288.6,240,237.5,86,75.9,89.4,3.0485475527258257,1.6081220500280595,5.5685444728162143E-4,3.254258307524818,0.016722767401441924,1.7766918508370009,260]
["High","Q96S55-1","ATPase WRNIP1 [OS=Homo sapiens]",12,7,15,7,665,72.1,6.1,31.84,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","WRNIP1","ENSG00000124535; ENSPTRG00000017666","","","",496.8,484.9,496.7,514.3,494.3,502.7,0.9782306623436777,-0.03175340866405168,0.19305722311580065,0.7143139448783162,0.3669403111217555,0.4354045751449213,4108]
["High","Q96S99","Pleckstrin homology domain-containing family F member 1 [OS=Homo sapiens]",7,2,2,2,279,31.2,8.24,1.73,"cell organization and biogenesis;other biological processes","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PLEKHF1","ENSG00000166289","","","",72.4,65.2,55,84.5,80.6,83.3,0.7753623188405798,-0.36705747037702185,0.02291614547904495,1.6398584293729441,0.09547986334065259,1.020088211266068,1874]
["High","Q96SB8","structural maintenance of chromosomes protein 6 [OS=Homo sapiens]",26,27,50,27,1091,126.2,6.99,113.81,"cell organization and biogenesis;DNA metabolism;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC6","ENSG00000163029","","SUMOylation of DNA damage response and repair proteins","",2641.9,2604.3,2624.1,2683.5,2764.6,2607.1,0.9770458834045089,-0.03350178018009043,0.25782044309522256,0.5886826495448775,0.441267430882836,0.35529812582687187,4562]
["High","Q96SQ9","Cytochrome P450 2S1 [OS=Homo sapiens]",24,13,55,13,504,55.8,8.62,158.41,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","CYP2S1","ENSG00000167600","Vitamin D receptor pathway; Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II","CYP2E1 reactions; Miscellaneous substrates","Retinol metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways",2099.1,2149.9,2132.3,2306.2,2330.7,2372.7,0.9103657840675644,-0.13548175965464826,1.0234375866270873E-3,2.9899386372320045,0.021423594306660316,1.6691076643820568,373]
["High","Q96ST8","Centrosomal protein of 89 kDa [OS=Homo sapiens]",3,3,3,3,783,89.5,6.8,5.59,"cell-cell signaling;cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","","CEP89","ENSG00000121289","","Anchoring of the basal body to the plasma membrane","",231.7,201.2,194.5,197.5,157.1,173.5,1.188032569589093,0.24857438777216442,0.1135788135327515,0.9447026723568237,0.2606004631395015,0.5840248167939976,3403]
["High","Q96T21","selenocysteine insertion sequence-binding protein 2 [OS=Homo sapiens]",13,7,9,7,854,95.4,8.12,24.57,"protein metabolism;other metabolic processes;developmental processes;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","SECISBP2","ENSG00000187742","","Selenocysteine synthesis","",373.3,385.5,398.4,487.6,408.9,432,0.8710575837410612,-0.19915999944826954,0.07981376006134824,1.0979222289054853,0.20772861285300234,0.6825036789665124,3000]
["High","Q96T51","RUN and FYVE domain-containing protein 1 [OS=Homo sapiens]",25,16,34,14,708,79.8,5.74,68.63,"transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RUFY1","ENSG00000176783; ENSG00000284260","","Synthesis of PIPs at the plasma membrane","Endocytosis",1862,1649.4,1675.8,1614.5,1533.5,1519.5,1.1113444027852168,0.15230597351661476,0.07700483195329251,1.1134820225572377,0.2029205966558582,0.6926738693786535,2963]
["High","Q96TC7","Regulator of microtubule dynamics protein 3 [OS=Homo sapiens]",20,10,27,10,470,52.1,5.1,37.86,"other biological processes","non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component","cytoskeletal activity","RMDN3","ENSG00000137824","","","",1203.4,1160.5,1185.5,1138.7,1091.4,1129.3,1.0565577186402333,0.07937158234289879,0.029361722264540927,1.5322184736861677,0.11048497708025809,0.9566967700756438,2075]
["High","Q99460","26S proteasome non-ATPase regulatory subunit 1 [OS=Homo sapiens]",51,38,225,38,953,105.8,5.39,535.16,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","PSMD1","ENSG00000173692","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Neutrophil degranulation","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",9129.5,9487.3,9255.8,9072.2,9569.7,9314.8,0.9969917765687654,-0.004346489915234504,0.8823441684420393,0.05436198028756691,0.931873835681786,0.03064288182644887,7393]
["High","Q99487","Platelet-activating factor acetylhydrolase 2, cytoplasmic [OS=Homo sapiens]",12,3,4,3,392,44,6.89,9.99,"other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PAFAH2","ENSG00000158006","","Platelet homeostasis","Ether lipid metabolism; Metabolic pathways",67.3,89.3,58.4,74.9,65.2,67.7,1.0346487006737248,0.049141005572610995,0.8155143761729341,0.08856837866105106,0.8936892981274763,0.04881344268296352,7125]
["High","Q99538","Legumain [OS=Homo sapiens]",17,5,17,5,433,49.4,6.55,39.85,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","LGMN","ENSG00000100600","","MHC class II antigen presentation; Trafficking and processing of endosomal TLR; Vitamin D (calciferol) metabolism","Lysosome; Antigen processing and presentation",582.4,596.8,588.9,502,488.4,525.9,1.1660621249093188,0.22164465381369844,0.002015282143806495,2.6956641431107684,0.02897849535698179,1.53792416804098,543]
["High","Q99570","Phosphoinositide 3-kinase regulatory subunit 4 [OS=Homo sapiens]",15,14,32,14,1358,153,7.17,45.52,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIK3R4","ENSG00000196455","Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Ciliopathies; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; DNA damage response (only ATM dependent)","PI3K Cascade; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade","Autophagy; Autophagy; Apelin signaling pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis",873.5,967.2,895.5,805,914.7,861.7,1.0599674595180908,0.08401997543707765,0.29116126917805035,0.5358663961892048,0.4779035505028836,0.3206597429504711,4757]
["High","Q99611","Selenide, water dikinase 2 [OS=Homo sapiens]",9,2,5,2,448,47.3,5.88,5.26,"other metabolic processes","cytosol;other cell component","kinase activity;other molecular function","SEPHS2","ENSG00000179918","Selenium micronutrient network","Selenocysteine synthesis","Selenocompound metabolism; Metabolic pathways",23.7,18,20.6,23.6,12.9,21.7,1.070446735395189,0.09821301011571797,0.7295248138545887,0.13695993154730032,0.8380358609057861,0.07673739681092663,6797]
["High","Q99614","tetratricopeptide repeat protein 1 [OS=Homo sapiens]",48,11,22,11,292,33.5,4.84,48.22,"other biological processes","cytosol","other molecular function","TTC1","ENSG00000113312","","","",1102.4,1071.7,1210.2,1591.2,1078.1,998.6,0.922680552904932,-0.11609684518546784,0.6455824642301244,0.19004827474125754,0.7786079519167148,0.10868116514917643,6474]
["High","Q99666","RANBP2-like and GRIP domain-containing protein 5/6 [OS=Homo sapiens]",22,37,115,1,1765,198.8,6.42,239.39,"transport;other biological processes","nucleus;other cell component","","RGPD5; RGPD6","ENSG00000015568; ENSG00000183054","","","",149.4,126.9,147.9,201.9,210.3,204.7,0.6876317069217053,-0.5402920253999691,1.1126602684449097E-3,2.9536374197284947,0.02227602916927655,1.6521622220963585,390]
["High","Q99707","methionine synthase [OS=Homo sapiens]",7,7,10,7,1265,140.4,5.58,16.9,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol","other molecular function","MTR","ENSG00000116984","Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Vitamin B12 disorders; Male infertility","RHOH GTPase cycle; Cobalamin (Cbl, vitamin B12) transport and metabolism; Methylation; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG","Cysteine and methionine metabolism; Selenocompound metabolism; One carbon pool by folate; Metabolic pathways; Biosynthesis of amino acids",232.3,220.2,223.6,244.8,222.1,236.3,0.9614618885096701,-0.05669842333137246,0.2969287502199854,0.5273477496677135,0.4841135271909889,0.31505278205168585,4789]
["High","Q99732","Lipopolysaccharide-induced tumor necrosis factor-alpha factor [OS=Homo sapiens]",4,1,2,1,161,17.1,6.44,4.15,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","LITAF","ENSG00000189067","Intracellular trafficking proteins involved in CMT neuropathy","","Lysosome",203.3,193.9,226.8,237.1,248.2,243.2,0.856554564172958,-0.22338294320226437,0.027710512694385174,1.5573554389134534,0.10663562499643146,0.9720976812881641,2029]
["High","Q99807-1","5-demethoxyubiquinone hydroxylase, mitochondrial [OS=Homo sapiens]",13,2,2,2,217,24.3,8.59,3.09,"other metabolic processes;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","COQ7","ENSG00000167186","","Ubiquinol biosynthesis","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",40.2,47.1,38.5,44.5,49.4,51.6,0.8646048109965636,-0.20988723091635694,0.1226850292856086,0.9112084290849032,0.27487079158164474,0.560871406860296,3485]
["High","Q99816","tumor susceptibility gene 101 protein [OS=Homo sapiens]",22,10,28,10,390,43.9,6.46,63.9,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TSG101","ENSG00000074319","Ebola virus infection in host; 7q11.23 copy number variation syndrome","HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy","Endocytosis",1565.5,1482.5,1457.6,1607.9,1565.3,1549.7,0.9539901331808848,-0.0679537499192796,0.121630437813472,0.9149577299951837,0.273056486040135,0.5637475030032418,3478]
["High","Q99933","BAG family molecular chaperone regulator 1 [OS=Homo sapiens]",26,7,13,7,345,38.8,7.81,33.93,"signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","other molecular function","BAG1","ENSG00000107262","Androgen receptor signaling pathway","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",451.6,500.8,507.8,486.5,506.4,456.2,1.007659926851149,0.011008828693413433,0.8796195084603113,0.05570514729361299,0.9300025893105093,0.03151584228294589,7385]
["High","Q9BPU6","Dihydropyrimidinase-related protein 5 [OS=Homo sapiens]",35,14,40,14,564,61.4,7.2,122.07,"cell organization and biogenesis;developmental processes;signal transduction","cytosol;other cell component","cytoskeletal activity;other molecular function","DPYSL5","ENSG00000157851","","CRMPs in Sema3A signaling","Axon guidance",1577.7,1596.3,1618.9,1667.9,1640,1677.6,0.9613679671046034,-0.05683936138164787,0.01732083916897781,1.761431070885193,0.08196431044325984,1.0863752104404638,1650]
["High","Q9BPX5","actin-related protein 2/3 complex subunit 5-like protein [OS=Homo sapiens]",50,6,10,6,153,16.9,6.6,27.79,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity","ARPC5L","ENSG00000136950","Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling pathway","","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",194.6,132.3,208,204.1,149.2,162,1.038036095478362,0.0538566111931221,0.8306118929488233,0.08060185482369657,0.9038909630863292,0.04388395557109113,7175]
["High","Q9BQ69","O-acetyl-ADP-ribose deacetylase MACROD1 [OS=Homo sapiens]",9,3,4,3,325,35.5,9.51,2.4,"protein metabolism;other metabolic processes;stress response","nucleus","other molecular function","MACROD1","ENSG00000133315","","","",122.5,132.9,142.6,132.5,135.3,125,1.0132382892057026,0.01897350111631803,0.8048842443256321,0.0942665738749018,0.8886504778979829,0.051269021221283094,7072]
["High","Q9BQB6-1","vitamin K epoxide reductase complex subunit 1 [OS=Homo sapiens]",12,2,4,2,163,18.2,9.36,8.05,"protein metabolism;other metabolic processes;stress response;developmental processes","other membranes;ER/Golgi","other molecular function","VKORC1","ENSG00000167397; ENSPPAG00000037377; ENSPPYG00000007306; ENSPTRG00000008031","","Metabolism of vitamin K","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",389.1,389,381.6,341.8,346.4,369.5,1.0964356622860925,0.1328211586380223,0.018932296345980926,1.7227967061680745,0.08609398361643511,1.0650271966703555,1717]
["High","Q9BQE5","apolipoprotein L2 [OS=Homo sapiens]",18,6,7,6,337,37.1,6.74,19.08,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","APOL2","ENSG00000128335","","","",480.3,500.9,486.9,578.6,581.7,625.4,0.8221425771406169,-0.2825394850476893,2.888390428185326E-3,2.539344102880081,0.03282758728278169,1.4837610352809962,687]
["High","Q9BQP7","mitochondrial genome maintenance exonuclease 1 [OS=Homo sapiens]",24,7,16,7,344,39.4,7.68,32.53,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","mitochondrion","other molecular function","MGME1","ENSG00000125871","","","",899.8,933.6,880.7,1015.8,1006.9,1030.5,0.888936198087253,-0.16984821914647863,2.6147584300468254E-3,2.5825684281518844,0.03126498288178501,1.504941804768323,653]
["High","Q9BQS8","fyve and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",4,5,5,5,1478,166.9,4.92,8.18,"transport;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FYCO1","ENSG00000163820","","","Salmonella infection",118,116.4,120.9,149.1,130.8,127,0.8731875153600394,-0.1956365917424883,0.06854026027440391,1.1640542507155658,0.18764458352824182,0.7266639672367583,2852]
["High","Q9BRG1","Vacuolar protein-sorting-associated protein 25 [OS=Homo sapiens]",30,3,5,3,176,20.7,6.34,5.87,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS25","ENSG00000131475","","HCMV Late Events; Endosomal Sorting Complex Required For Transport (ESCRT)","Endocytosis",87.6,120.1,108,107.6,116.6,113.4,0.9351303317535544,-0.0967606433942002,0.49945943620205435,0.3014997774058957,0.6693750906051562,0.1743304530389088,5826]
["High","Q9BRP8","Partner of Y14 and mago [OS=Homo sapiens]",27,4,5,4,204,22.6,9.45,10.55,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity","PYM1","ENSG00000170473","","","Nucleocytoplasmic transport; mRNA surveillance pathway",73.8,79.2,71.1,108.5,88.7,74.9,0.8235942668136714,-0.27999430773928535,0.1861530590266964,0.7301298226876061,0.35791260400897457,0.44622300751900756,4061]
["High","Q9BRS8","La-related protein 6 [OS=Homo sapiens]",15,5,7,5,491,54.7,8.25,9.61,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity","LARP6","ENSG00000166173","","","",196.9,198.9,212.9,197.6,172,175.9,1.1158570119156737,0.15815216926684553,0.08899303146984767,1.0506439991155228,0.223139881090742,0.6514228026889888,3114]
["High","Q9BRT9","DNA replication complex GINS protein SLD5 [OS=Homo sapiens]",34,6,14,6,223,26,4.98,27.89,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes","nucleus;other cell component","","GINS4","ENSG00000147536","","Unwinding of DNA","",759.3,665.7,747.8,643.9,573.8,574.3,1.2125000000000004,0.27798474729976574,0.027796164436854086,1.5560151277809335,0.10675477221985082,0.9716127017603367,2033]
["High","Q9BS26","Endoplasmic reticulum resident protein 44 [OS=Homo sapiens]",47,18,54,18,406,46.9,5.26,119.58,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","ERP44","ENSG00000023318","","Neutrophil degranulation","",2470.3,2353.5,2433.2,2296.8,2288.6,2267,1.0590450061292394,0.08276390069925726,0.019268164000841873,1.7151596658474553,0.08681236267661474,1.0614184239027369,1733]
["High","Q9BSD7","Cancer-related nucleoside-triphosphatase [OS=Homo sapiens]",72,11,29,11,190,20.7,9.54,77.55,"","","other molecular function","NTPCR","ENSG00000135778","","","Purine metabolism; Thiamine metabolism; Metabolic pathways",1322.2,1348.9,1357.1,1405.6,1486.1,1396.2,0.9394342218801744,-0.09013594557786002,0.04656500073582509,1.3319403858462922,0.14719818856085923,0.8320975344473224,2470]
["High","Q9BSJ2-1","Gamma-tubulin complex component 2 [OS=Homo sapiens]",12,10,14,10,902,102.5,6.84,32.13,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","TUBGCP2","ENSG00000130640","15q11.2 copy number variation syndrome","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","",475.9,509.5,517.2,542.8,557.7,571.1,0.8988992581957407,-0.1537686563950213,0.020222368623956925,1.6941679773272262,0.08850686895507605,1.0530230227086952,1784]
["High","Q9BSQ5-1","Cerebral cavernous malformations 2 protein [OS=Homo sapiens]",16,5,5,5,444,48.8,5.54,5.73,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","mitochondrion;other cell component","","CCM2","ENSG00000136280","","","",242.1,215.8,254.5,193.3,210.8,221.1,1.1394753678822775,0.18836973810195431,0.10649240635245194,0.9726813593314001,0.25014822767748035,0.6018025697848381,3324]
["High","Q9BSY9","Desumoylating isopeptidase 2 [OS=Homo sapiens]",35,3,17,3,194,21.4,4.92,29.12,"protein metabolism;other metabolic processes","other cell component","other molecular function","DESI2","ENSG00000121644","","","",663.9,665.8,710.7,596.3,566.1,578.6,1.1719701321079838,0.2289358028584793,0.004795422190289957,2.3191731514043297,0.04202318345879235,1.3765110507825693,891]
["High","Q9BT67","NEDD4 family-interacting protein 1 [OS=Homo sapiens]",13,2,3,2,221,24.9,4.68,7.2,"protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","NDFIP1","ENSG00000131507","","","",86.6,101,93.3,117,128.2,136.6,0.7357255107386066,-0.44276047827753934,0.008784810321796198,2.0562676111848,0.056734325055901334,1.2461541073869364,1209]
["High","Q9BTC0","Death-inducer obliterator 1 [OS=Homo sapiens]",27,44,105,44,2240,243.7,7.88,264.18,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytoskeleton;nucleus;other cell component","other molecular function","DIDO1","ENSG00000101191","","","",3787.4,3915.9,4040.2,4512.4,4161.4,4443.5,0.8952680810837595,-0.15960834397607013,0.024291568929972612,1.6145444343251738,0.09899194687120363,1.0044001344090638,1916]
["High","Q9BTE7","DCN1-like protein 5 [OS=Homo sapiens]",30,6,13,6,237,27.5,5.58,16.27,"protein metabolism;other metabolic processes;stress response;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","DCUN1D5","ENSG00000137692","","Neddylation","",524.4,436.8,462.6,563.1,429.2,465.7,0.9765432098765434,-0.03424421329919495,0.8227539330651366,0.0847300329419412,0.8987216996883864,0.04637477211691243,7148]
["High","Q9BTV4","Transmembrane protein 43 [OS=Homo sapiens]",30,13,47,13,400,44.8,8.13,116.42,"cell organization and biogenesis","other membranes;ER/Golgi;nucleus","other molecular function","TMEM43","ENSG00000170876","Envelope proteins and their potential roles in EDMD physiopathology","","",2372.5,2382.6,2220.5,2088.6,2123.6,2194.3,1.0888316553500352,0.12278091570238203,0.035797297912466546,1.4461497539704833,0.12511428025986518,0.902693118091438,2234]
["High","Q9BTZ2","dehydrogenase/reductase sdr family member 4 [OS=Homo sapiens]",11,2,2,2,278,29.5,8.56,7.68,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","DHRS4","ENSG00000157326; ENSG00000284807","","Peroxisomal protein import; RA biosynthesis pathway","Retinol metabolism; Metabolic pathways; Peroxisome",127.4,141.8,142.4,119,124,123.9,1.1218315617334425,0.16585607764542581,0.045005998334594836,1.3467296002244518,0.14407824313100306,0.841401595879547,2439]
["High","Q9BUB7","Transmembrane protein 70, mitochondrial [OS=Homo sapiens]",10,2,2,2,260,29,8.91,5.65,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","TMEM70","ENSG00000175606","","","",93.5,120.1,107.7,94.4,117.3,105.1,1.0142045454545456,0.0203486453918027,0.8895546060095906,0.05082738725319347,0.9364490176247652,0.028515861606352493,7417]
["High","Q9BUI4","DNA-directed RNA polymerase III subunit RPC3 [OS=Homo sapiens]",37,14,21,14,534,60.6,7.31,42.06,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3C","ENSG00000186141","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",770.4,784,801.4,837,860.4,806.7,0.9407771255141567,-0.08807511263451924,0.05114681348022642,1.2911814182775756,0.155390785857435,0.8085747369502347,2570]
["High","Q9BUP0","EF-hand domain-containing protein D1 [OS=Homo sapiens]",18,4,11,2,239,26.9,5.39,17.37,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","EFHD1","ENSG00000115468","","","",197.5,178.7,154.9,190.7,195.4,217.7,0.8795958926796953,-0.18508722742080003,0.1786275815889778,0.7480514815781838,0.3491174360567556,0.4570284605695586,3995]
["High","Q9BV23","Monoacylglycerol lipase ABHD6 [OS=Homo sapiens]",8,2,2,2,337,38.3,8.41,2.68,"other metabolic processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ABHD6","ENSG00000163686","","Arachidonate production from DAG","Retrograde endocannabinoid signaling",42.4,36.6,38.9,42.2,27.6,44.7,1.0296943231441047,0.04221611999545621,0.8493013340648621,0.07093819373396403,0.9144159978458968,0.038856184498799656,7252]
["High","Q9BV68-2","Isoform 2 of E3 ubiquitin-protein ligase RNF126 [OS=Homo sapiens]",28,4,9,4,311,33.8,5.47,16.16,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","RNF126","ENSG00000070423; ENSPTRG00000010160","","Antigen processing: Ubiquitination & Proteasome degradation","",210.8,216,228.3,233.6,205.6,211.7,1.0064526040866493,0.009279234396211767,0.8950033389588108,0.04817534447327024,0.939903977214579,0.026916512672607855,7435]
["High","Q9BVA0","Katanin p80 WD40 repeat-containing subunit B1 [OS=Homo sapiens]",25,13,22,13,655,72.3,7.56,54.32,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KATNB1","ENSG00000140854","Genes related to primary cilium development (based on CRISPR)","","",862.9,831.1,877.2,948.5,898.3,962.5,0.915245790766383,-0.12776886132550577,0.028901171920271692,1.5390845465795024,0.10922572621175283,0.9616750591044687,2066]
["High","Q9BVG3","E3 ubiquitin-protein ligase TRIM62 [OS=Homo sapiens]",5,2,4,2,475,54.2,6.62,8.74,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","TRIM62","ENSG00000116525","","Interferon gamma signaling","",117.6,101.2,110.1,98.1,109.6,107.4,1.043795620437956,0.061839253817862316,0.4796095362189625,0.319112190281071,0.6537694236727757,0.18457539492223476,5728]
["High","Q9BVJ6-1","U3 small nucleolar RNA-associated protein 14 homolog A [OS=Homo sapiens]",26,19,39,19,771,87.9,7.87,77.94,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","UTP14A","ENSG00000156697","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1447,1465.4,1464.9,1548.9,1342.5,1494.5,0.9980391709797307,-2.8316554077880644E-3,0.9653708881506332,0.015305801960427908,0.9815882139184977,0.008070664890760483,7679]
["High","Q9BVM4","gamma-glutamylaminecyclotransferase [OS=Homo sapiens]",8,1,2,1,153,17.3,6.87,3.18,"other metabolic processes","cytosol","other molecular function","GGACT","ENSG00000134864","","","",100.7,80.3,86.2,86.5,83.7,93.9,1.0117379780386215,0.016835706306959013,0.8862722069282609,0.05243286974898911,0.9342531918044905,0.029535409741948425,7407]
["High","Q9BVV7","Mitochondrial import inner membrane translocase subunit TIM21 [OS=Homo sapiens]",12,3,4,3,248,28.2,9.7,0,"cell organization and biogenesis;transport","other membranes;mitochondrion","","TIMM21","ENSG00000075336","","Mitochondrial protein import","",67.7,72,72.8,73.2,70.2,74.6,0.9747706422018347,-0.03686529375186245,0.4211837876931454,0.3755283541316471,0.6021979517136201,0.22026072600855506,5461]
["High","Q9BW71-1","HIRA-interacting protein 3 [OS=Homo sapiens]",11,6,8,6,556,61.9,8.54,20.65,"cell organization and biogenesis","nucleus","","HIRIP3","ENSG00000149929","22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome","","",485.7,460.6,445.8,436.3,388.2,417.6,1.1207632235729812,0.16448152144581013,0.05159780819742181,1.2873687462019023,0.15627450985472052,0.8061118545606513,2578]
["High","Q9BWE0","Replication initiator 1 [OS=Homo sapiens]",22,8,13,8,567,63.5,9.98,42.77,"other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","REPIN1","ENSG00000214022","","","",674.8,688.7,695.2,703.8,648.8,744.6,0.9816421895861147,-0.026730839571687176,0.6747845828675998,0.17083484850735836,0.7995019761806099,0.0971804584427328,6590]
["High","Q9BWS9-1","Chitinase domain-containing protein 1 [OS=Homo sapiens]",24,7,12,7,393,44.9,8.63,16.38,"other metabolic processes;stress response;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle","other molecular function","CHID1","ENSG00000177830","","Platelet degranulation","",285.5,312.1,312.4,296.6,264.8,291.3,1.0671983112466283,0.09382828869094309,0.22365233916559019,0.650426555209207,0.4034837024503069,0.3941740026490846,4328]
["High","Q9BX66-12","Isoform 12 of Sorbin and SH3 domain-containing protein 1 [OS=Homo sapiens]",5,5,7,5,1294,143.7,8.6,11.95,"","","","SORBS1","","","","",296.7,293.1,307.2,284,283.6,287.5,1.0490001169453864,0.06901483875075695,0.033891155979953874,1.4699136177323122,0.12061173468162255,0.918610436312369,2194]
["High","Q9BXA9","sal-like protein 3 [OS=Homo sapiens]",7,7,7,6,1300,135.3,6.99,16.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SALL3","ENSG00000256463; ENSG00000277015","","","",295.6,300.9,284.5,332.5,296.8,307.6,0.9403351478279433,-0.08875305093395343,0.18414499014396243,0.7348400920815569,0.35554007988230923,0.449111434341885,4044]
["High","Q9BXF6","Rab11 family-interacting protein 5 [OS=Homo sapiens]",10,5,7,5,653,70.4,9.23,14.76,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB11FIP5","ENSG00000135631","","","Endocytosis",259,260.7,278.9,312.1,284.7,299.2,0.8912946428571428,-0.16602566031191865,0.03302753374202339,1.4811238550769643,0.11883824122475513,0.9250437842668584,2170]
["High","Q9BXP5","serrate RNA effector molecule homolog [OS=Homo sapiens]",42,40,132,40,876,100.6,5.96,233.1,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SRRT","ENSG00000087087","","mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes","",6380.6,5601.9,5947.7,6492.4,6135.2,6577.3,0.9336263141177514,-0.09908287112553517,0.18128759388322577,0.7416319151124835,0.35211281916423554,0.45331816353831816,4020]
["Medium","Q9BXT8","Ring finger protein 17 [OS=Homo sapiens]",1,1,4,1,1623,184.5,5.4,0,"other biological processes","nucleus;other cell component","other molecular function","RNF17","ENSG00000132972","","","",173,175.6,129,147.1,222.9,154.2,0.9111026325829836,-0.1343145170636124,0.6148101233292055,0.21125899011533691,0.7566893825590222,0.12108235976624887,6344]
["High","Q9BY11","Protein kinase C and casein kinase substrate in neurons protein 1 [OS=Homo sapiens]",7,3,3,1,444,50.9,5.24,7.13,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","PACSIN1","ENSG00000124507","","Clathrin-mediated endocytosis","",26.3,21.8,23.5,32,22.7,23.5,0.9156010230179027,-0.12720902004309606,0.5358205437480036,0.27098063924338534,0.697397367158595,0.15651969652220496,5999]
["High","Q9BY77","Polymerase delta-interacting protein 3 [OS=Homo sapiens]",38,14,32,1,421,46.1,9.99,82.46,"other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","POLDIP3","ENSG00000100227","","mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",1008.7,1129,1096.5,1146,1147.9,1095.8,0.9541257338407529,-0.0677486990591683,0.2624583888378667,0.5809395415174025,0.4466597864093425,0.3500231460879971,4588]
["High","Q9BYD2","39S ribosomal protein L9, mitochondrial [OS=Homo sapiens]",24,6,14,6,267,30.2,10.08,27.86,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL9","ENSG00000143436","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",559.4,517.7,545.5,542.6,530,480.2,1.0449510561566202,0.06343537035041204,0.3624426219332061,0.44076073654165165,0.5468506264839561,0.26213128601197166,5175]
["High","Q9BYG3","MKI67 FHA domain-interacting nucleolar phosphoprotein [OS=Homo sapiens]",41,10,39,10,293,34.2,9.88,97.72,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","NIFK","ENSG00000155438","","","",1711.2,1875.6,1852.8,1861.9,1969.3,1880.2,{"$f":"AVERAGE(T6146:V6146)/AVERAGE(W6146:Y6146)","v":0.952410967538607},{"$f":"LOG(Z6146,2)","v":-0.07034386075280864},{"$f":"TTEST(T6146:V6146,W6146:Y6146,2,2)","v":0.2128435700292944},{"$f":"-LOG10(AB6146)","v":0.6719394652565244},{"$f":"AB6146*7808/AF6146","v":0.39029652296588324},{"$f":"-LOG10(AD6146)","v":0.40860531770019276},4258]
["High","Q9BYK8-1","Helicase with zinc finger domain 2 [OS=Homo sapiens]",12,22,34,22,2649,294.5,7.49,66.93,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HELZ2","ENSG00000130589","","PPARA activates gene expression; Heme signaling; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); Transcriptional activation of mitochondrial biogenesis; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RORA activates gene expression","",786.4,743.7,794.9,626.5,632,662.8,1.210118149169833,0.2751479110536571,0.002292881070071415,2.6396184711973323,0.030088765369945557,1.5215956322672464,595]
["High","Q9BYV8","centrosomal protein of 41 kDa [OS=Homo sapiens]",14,3,6,3,373,41.3,8.32,12.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","cytosol;cytoskeleton;other cell component","","CEP41","ENSG00000106477","Joubert syndrome; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",104.8,83.9,110.2,117.1,125.3,105.8,0.8584147041929925,-0.2202533059730067,0.16926959065491629,0.7714210560492656,0.3368137012827692,0.472610250098541,3924]
["High","Q9BZ29-4","Isoform 4 of Dedicator of cytokinesis protein 9 [OS=Homo sapiens]",1,2,2,2,2093,238.7,7.62,3.24,"","","","DOCK9","","","","",69.5,77.5,68.9,50.4,56.4,63.7,1.266275659824047,0.34059150411097056,0.03314152946162231,1.4796274530254463,0.11908378372588449,0.9241473746873354,2173]
["High","Q9BZE2","tRNA pseudouridine(38/39) synthase [OS=Homo sapiens]",9,4,5,4,481,55.6,7.49,12.14,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PUS3","ENSG00000110060","","tRNA modification in the nucleus and cytosol","",267.6,252.1,250.8,286,286,257,0.9294330518697226,-0.10557714498096506,0.1529721767660171,0.8153875533380751,0.31448308483124315,0.5024027090804384,3798]
["High","Q9BZH6","WD repeat-containing protein 11 [OS=Homo sapiens]",13,13,29,13,1224,136.6,6.92,55.92,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","WDR11","ENSG00000120008","","RHOH GTPase cycle","",1080.7,1261.1,1064,977.3,1293.3,1011.6,1.03765766863689,0.053330565836125325,0.7452688724768969,0.1276870174975473,0.8504909903974878,0.07033028268795562,6842]
["High","Q9BZK7","F-box-like/WD repeat-containing protein TBL1XR1 [OS=Homo sapiens]",27,9,24,6,514,55.6,5.55,55.77,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1XR1","ENSG00000177565","Rett syndrome causing genes","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Heme signaling; HCMV Early Events; HDACs deacetylate histones; Transcriptional activation of mitochondrial biogenesis; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity","Wnt signaling pathway",641.5,665.7,702.1,777.6,771.4,785.7,0.860624491369341,-0.216544198274934,3.8934183792655934E-3,2.409668925322813,0.03814279887742253,1.41858744206029,797]
["High","Q9BZV1","UBX domain-containing protein 6 [OS=Homo sapiens]",18,4,8,4,441,49.7,6.89,16.25,"protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","","UBXN6","ENSG00000167671","","","Protein processing in endoplasmic reticulum",106.3,111.5,100.2,130.9,132.6,130.3,0.8075165058405281,-0.3084363457298361,1.6317745454639818E-3,2.7873398458424115,0.026433393466769234,1.5778470794226254,482]
["High","Q9C0B7","Transport and Golgi organization protein 6 homolog [OS=Homo sapiens]",13,9,13,9,1094,120.7,6.11,31.53,"transport","other membranes","","TANGO6","ENSG00000103047","","","",445.8,435.1,402,494,436.9,456.8,0.9244793543273043,-0.1132869934755207,0.17638523030556247,0.7535377835201984,0.34620811418447256,0.46066275764997977,3978]
["High","Q9C0C2","182 kDa tankyrase-1-binding protein [OS=Homo sapiens]",59,72,216,72,1729,181.7,4.86,497.34,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TNKS1BP1","ENSG00000149115","Ciliary landscape","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",7821.8,7884.3,8014.2,8873.8,7626.8,7865.2,0.9735079496671564,-0.03873533484414944,0.6072777223916459,0.21661265041018393,0.7507321811960056,0.12451496708780516,6316]
["High","Q9C0H2-1","Protein tweety homolog 3 [OS=Homo sapiens]",7,4,14,4,523,57.5,5.39,35.23,"transport","plasma membrane;other membranes","transporter activity","TTYH3","ENSG00000136295","","Stimuli-sensing channels","",527.2,534.2,477,393.7,371.3,407.6,1.3119563363465805,0.39171970594342437,0.004292630040836728,2.367276539460613,0.039524593583553265,1.4031325870586915,848]
["High","Q9C0J8","pre-mRNA 3' end processing protein WDR33 [OS=Homo sapiens]",18,19,34,19,1336,145.8,9.17,53.9,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","WDR33","ENSG00000136709","","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",1564.6,1475.5,1531.9,1813.7,1478,1626,0.929702909896903,-0.10515832371313104,0.3157214284105974,0.5006959409945164,0.5028871711607394,0.29852944325194014,4902]
["High","Q9GZP9","Derlin-2 [OS=Homo sapiens]",16,2,5,2,239,27.5,7.28,13.02,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","DERL2","ENSG00000072849","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",99.3,121.1,105.1,72.2,69.8,72.5,1.5174825174825175,0.6016798956660899,0.00490322339792103,2.309518319220854,0.04234996492363651,1.3731469450375817,904]
["High","Q9GZT4","serine racemase [OS=Homo sapiens]",9,2,4,2,340,36.5,6.54,5.29,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","SRR","ENSG00000167720","Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; D-Amino acid metabolism; Metabolic pathways",65,70.9,64.4,54,52.4,62.1,1.1887240356083086,0.24941382974348691,0.043903270705390456,1.3575031244870044,0.14200361958064983,0.8477005855896993,2414]
["High","Q9GZU8","Protein FAM192A [OS=Homo sapiens]",27,6,10,6,254,28.9,5.45,17.06,"other biological processes","nucleus","","PSME3IP1","ENSG00000172775","","","",479.5,435.8,467,792,523,505.7,0.7592134893172956,-0.3974224692323969,0.19345437661457845,0.7134214405715292,0.3674268481164263,0.43482911269324365,4111]
["High","Q9GZY8-1","Mitochondrial fission factor [OS=Homo sapiens]",28,5,10,5,342,38.4,8.95,19.97,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","C2orf33; MFF","ENSG00000168958","","","",118.6,117.9,101.9,111.9,106.1,93.2,1.0874035989717223,0.12088750813375777,0.30777060592423044,0.5117728604450551,0.49486674033286476,0.3055117338536209,4856]
["High","Q9H019-1","Mitochondrial fission regulator 1-like [OS=Homo sapiens]",25,5,12,5,292,31.9,6.1,27.63,"cell organization and biogenesis;other metabolic processes","mitochondrion","","FAM54B; MTFR1L","ENSG00000117640; ENSPPAG00000030443","","","",269.4,284.4,291.9,317.7,261.9,252.2,1.0167107477759076,0.02390929364522169,0.839585590077204,0.07593502388151352,0.9078360735802256,0.04199256421757057,7221]
["High","Q9H089","Large subunit GTPase 1 homolog [OS=Homo sapiens]",24,14,30,14,658,75.2,6.38,64.71,"transport","cytosol;ER/Golgi;nucleus","other molecular function","LSG1","ENSG00000041802","","","Ribosome biogenesis in eukaryotes",1261.6,1265.4,1241.5,1234,1249.4,1300.5,0.9959301250033036,-0.0058835693083798,0.8223967476303506,0.08491861586945225,0.8984572275776939,0.04650259331198391,7147]
["High","Q9H0A8-1","COMM domain-containing protein 4 [OS=Homo sapiens]",37,6,8,6,199,21.8,7.31,22.09,"","plasma membrane;other membranes;cytosol;nucleus;other cell component","","COMMD4","ENSG00000140365; ENSGGOG00000014844","","Neddylation","",278,344.9,300.7,258.3,386.3,323.5,0.9540336742072099,-0.06788790543398326,0.740896604798823,0.13024239539239682,0.8472350161495622,0.07199610317645737,6828]
["High","Q9H0G5","Nuclear speckle splicing regulatory protein 1 [OS=Homo sapiens]",20,9,13,9,558,66.4,8.84,21.21,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","NSRP1","ENSG00000126653","","","",677,615.6,628.3,708.2,700.9,697.8,0.9117186387583656,-0.13333942520772468,0.030812355748295352,1.5112750965751567,0.1135896476311096,0.9446612476879873,2118]
["High","Q9H0Q0","Protein FAM49A [OS=Homo sapiens]",18,4,5,4,323,37.3,6.01,9.92,"cell organization and biogenesis","other membranes","other molecular function","CYRIA","ENSG00000197872","","","",152.2,126.9,135.3,91.7,88.4,84,1.5691026126467247,0.649939701519461,2.9729681959655635E-3,2.5268097367387345,0.03320877778841076,1.4787471078257806,699]
["High","Q9H0R8-1","Gamma-aminobutyric acid receptor-associated protein-like 1 [OS=Homo sapiens]",13,2,4,1,117,14,8.73,6.43,"cell organization and biogenesis;other metabolic processes;stress response","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","gabarapl1; Gabarapl1; GABARAPL1; gabarapl1.L; GBRL1; LOC101346525; LOC110090845; LOC111142199; LOC113417224; LOC113444478; LOC113982994","ENSACUG00000002920; ENSAMEG00000026339; ENSANAG00000017627; ENSBIXG00000025666; ENSBIXG00005000420; ENSBMUG00000009257; ENSBTAG00000011765; ENSCAFG00000013479; ENSCANG00000037817; ENSCATG00000043779; ENSCCAG00000031173; ENSCGRG00001022681; ENSCGRG00015025519; ENSCHIG00000025179; ENSCJAG00000048408; ENSCPOG00000006718; ENSCPRG00005001116; ENSCSAG00000009078; ENSFCAG00000022695; ENSG00000139112; ENSGAGG00000013450; ENSGALG00000014723; ENSGGOG00000022360; ENSLCNG00005007852; ENSLSDG00000014620; ENSMFAG00000037621; ENSMGAG00000014228; ENSMLEG00000037692; ENSMMUG00000002197; ENSMNEG00000040661; ENSMODG00000018255; ENSMUSG00000030161; ENSNLEG00000029077; ENSNVIG00000010216; ENSOGAG00000000859; ENSPANG00000015789; ENSPCLG00000013759; ENSPPAG00000035460; ENSPSIG00000008179; ENSPTRG00000052409; ENSPTXG00000014934; ENSRBIG00000038034; ENSRFEG00010012750; ENSRNOG00000053362; ENSRROG00000036376; ENSSBOG00000023150; ENSSHBG00005010614; ENSSTOG00000002246; ENSTGUG00000029032; ENSTMTG00000017402; ENSTSYG00000033601; ENSTTRG00000009099; ENSUAMG00000018185; ENSUMAG00000016270; ENSVVUG00000005149; ENSXETG00000016242","Senescence and autophagy in cancer","Macroautophagy; Macroautophagy; Macroautophagy; Macroautophagy; Macroautophagy","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse",121.8,108,130.8,114.5,118,103.9,1.0719381688466112,0.1002216911771974,0.36327437553151987,0.43976523510657795,0.5474708211059848,0.2616390227350638,5181]
["High","Q9H0W5","Coiled-coil domain-containing protein 8 [OS=Homo sapiens]",16,5,6,5,538,59.3,8.63,10.27,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","CCDC8","ENSG00000169515","","Neddylation","",201.2,187.7,208.1,241.5,229.5,219.6,0.8644656820156386,-0.21011940270121926,0.023181004830914946,1.6348677425284504,0.0962239690163657,1.0167167334201939,1881]
["High","Q9H0W9","Ester hydrolase C11orf54 [OS=Homo sapiens]",23,6,12,6,315,35.1,6.7,21.13,"","nucleus","other molecular function","C11orf54","ENSG00000182919","","","",445.1,400.5,409,460.7,448.2,438.5,0.9311266142199791,-0.10295073667654527,0.10998188915114167,0.9586788247444299,0.2557291812067046,0.5922197118878245,3358]
["High","Q9H1C4","Protein unc-93 homolog B1 [OS=Homo sapiens]",4,2,2,2,597,66.6,6.96,3.23,"stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding","UNC93B1","ENSG00000110057","","Trafficking and processing of endosomal TLR; UNC93B1 deficiency - HSE","",30.9,39.9,34.7,46.4,38.9,42.1,0.8281004709576137,-0.27212227866175304,0.09795250845917308,1.0089844377087802,0.2368575986525932,0.6255126780673064,3229]
["High","Q9H1K0","Rabenosyn-5 [OS=Homo sapiens]",8,6,8,6,784,88.8,5.5,18.35,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RBSN","ENSG00000131381","","Factors involved in megakaryocyte development and platelet production; Toll Like Receptor 9 (TLR9) Cascade","Endocytosis",419.5,407.6,430.9,419.2,415.6,401.2,1.017799352750809,0.025453178974914406,0.44616877712827824,0.35050082489787404,0.62588677898268,0.20350422223726278,5566]
["Low","Q9H211","DNA replication factor Cdt1 [OS=Homo sapiens]",1,1,1,1,546,60.4,9.77,1.75,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CDT1","ENSG00000167513","Retinoblastoma gene in cancer; DNA replication","Orc1 removal from chromatin; Activation of the pre-replicative complex; CDT1 association with the CDC6:ORC:origin complex; G1/S-Specific Transcription","",10.7,21.2,19.1,43.1,27.9,33.6,0.4875717017208413,-1.0363136993880835,0.030934098329390407,1.5095625383243505,0.11387715217156072,0.9435634021822769,2121]
["High","Q9H2D6","TRIO and F-actin-binding protein [OS=Homo sapiens]",9,16,28,16,2365,261.2,8.48,54.26,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TRIOBP","ENSG00000100106","","","",985.9,959.9,1042.4,989.8,1023.3,1009.7,0.9885536588593357,-0.016608817077320294,0.6827897340374814,0.1657130172649639,0.8048342758702679,0.09429353638315228,6624]
["High","Q9H2H8-1","peptidyl-prolyl cis-trans isomerase-like 3 [OS=Homo sapiens]",37,7,28,7,161,18.1,6.79,42.36,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","CLK1; LOC111141199; PPIL3","ENSAMEG00000005917; ENSCAFG00000011929; ENSECAG00000019985; ENSFCAG00000005373; ENSG00000240344; ENSGGOG00000022268; ENSOCUG00000010661; ENSPPAG00000039183; ENSPPYG00000013062; ENSPTRG00000012793; ENSRFEG00010017851; ENSSSCG00000016096; ENSSSCG00070023158; ENSSSUG00005004462; ENSSTOG00000028255; ENSUMAG00000021460","mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","",1008.3,1014.5,1029.4,1111.6,1092.1,1148.1,0.9106151918372218,-0.1350865667784403,0.004726083454744663,2.3254986137203466,0.04169633854762297,1.3799020797595367,885]
["High","Q9H2S1-1","Small conductance calcium-activated potassium channel protein 2 [OS=Homo sapiens]",2,1,1,1,579,63.7,9.52,2.44,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;cytoskeletal activity;other molecular function","KCNN2","ENSG00000080709","Brain-derived neurotrophic factor (BDNF) signaling pathway","Ca2+ activated K+ channels; Acetylcholine inhibits contraction of outer hair cells","Serotonergic synapse; Insulin secretion; GnRH secretion; Bile secretion",16.2,22.3,22,19.9,16.1,22.6,1.0324232081911262,0.04603447773970888,0.8284105668697075,0.0817543700587199,0.9022499241342832,0.04467314578612056,7169]
["High","Q9H329","Band 4.1-like protein 4B [OS=Homo sapiens]",4,4,14,1,900,99.7,9.04,16,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","EPB41L4B","ENSG00000095203","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","Tight junction",175.8,157,167.9,250.9,225.5,226.4,0.712435970404098,-0.489167735924621,2.4801143595292127E-3,2.6055282931385357,0.031033225832057844,1.5081730781623244,624]
["High","Q9H3C7","Gametogenetin-binding protein 2 [OS=Homo sapiens]",4,2,2,2,697,79,6.38,3.02,"developmental processes;other biological processes","nucleus;other cell component","","GGNBP2","ENSG00000275099; ENSG00000278311","","","",116.4,134,139.7,163.5,157.4,148.5,0.8310609288453344,-0.2669738434986082,0.03283297083919887,1.4836898190465593,0.11819264007029266,0.9274095664021172,2169]
["High","Q9H3K6-1","bola-like protein 2 [OS=Homo sapiens]",29,2,4,2,86,10.1,6.52,6.85,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","BOLA2; BOLA2B","ENSG00000169627; ENSG00000183336","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",118.2,115.8,139.8,153.3,128.1,119.7,0.9319371727748692,-0.1016953970693508,0.5118723363949259,0.2908383408066084,0.6784415553508031,0.16848755888396638,5891]
["High","Q9H3P2-1","Negative elongation factor A [OS=Homo sapiens]",39,14,43,14,528,57.2,9.03,96.4,"developmental processes;other biological processes","cytosol;nucleus","other molecular function","NELFA","ENSG00000185049","Initiation of transcription and translation elongation at the HIV-1 LTR","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1488.8,1427,1451.1,1693.2,1513.6,1581.3,0.9120319124496145,-0.13284378899809982,0.06427182856680089,1.191979344010955,0.17986897399626572,0.7450437426259171,2790]
["High","Q9H3Z4","DnaJ homolog subfamily C member 5 [OS=Homo sapiens]",20,4,12,4,198,22.1,5.07,29.22,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","DNAJC5","ENSG00000101152","","Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; GABA synthesis, release, reuptake and degradation","Protein processing in endoplasmic reticulum",592.5,595.1,574,555.3,576.7,558.6,1.041996924168934,0.05935101898611889,0.06552607746442575,1.183585829091666,0.18239843595088637,0.7389788900252109,2805]
["High","Q9H479","fructosamine-3-kinase [OS=Homo sapiens]",15,5,7,5,309,35.1,7.55,16.94,"protein metabolism;other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","FN3K","ENSG00000167363","","Gamma carboxylation, hypusine formation and arylsulfatase activation","",280.9,250.2,250.6,281.6,240.7,268.6,0.9883676823871539,-0.016880256642802433,0.8553625321217271,0.06784977728374914,0.9172738155207314,0.0375010036767109,7281]
["High","Q9H4B6","Protein salvador homolog 1 [OS=Homo sapiens]",20,6,10,6,383,44.6,9.09,16.57,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SAV1","ENSG00000151748","Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma","Signaling by Hippo","Hippo signaling pathway; Hippo signaling pathway",376.6,350,344.4,288.7,263.1,264.1,1.3126608653021206,0.39249423447588594,2.815157820742585E-3,2.5504972531194317,0.03232463568287956,1.4904663611670328,680]
["High","Q9H4G0-1","Band 4.1-like protein 1 [OS=Homo sapiens]",19,13,26,12,881,98.4,5.62,53.71,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","EPB41L1","ENSG00000088367","Splicing factor NOVA regulated synaptic proteins","Trafficking of AMPA receptors; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Neurexins and neuroligins","",577.4,649.7,580,680.7,656.8,679.9,0.8957569148408843,-0.15882081945090765,0.04828974757394215,1.3161450647908017,0.15045744176270562,0.8225863267902975,2506]
["High","Q9H4M3-2","Isoform 2 of F-box only protein 44 [OS=Homo sapiens]",13,2,2,2,224,25.7,7.88,5.88,"","","","FBXO44","","","","",70,49.3,49.5,55.3,45.5,55.2,1.0820512820512822,0.11376887495757465,0.6043576028475608,0.21870601007621324,0.7487819998466764,0.1256446042555587,6302]
["High","Q9H501","ESF1 homolog [OS=Homo sapiens]",25,19,44,19,851,98.7,5.11,98.45,"RNA metabolism OR transcription;other metabolic processes","nucleus","","ESF1","ENSG00000089048","","","",2271.7,2271.1,2388.4,2699.4,2509.8,2605.6,0.8869324870758045,-0.17310380351534485,0.011852119052074747,1.9262039947721887,0.06633788212085993,1.1782383977231696,1395]
["High","Q9H5L6","DNA transposase THAP9 [OS=Homo sapiens]",2,2,2,2,903,103.3,9.13,3.01,"DNA metabolism;other metabolic processes","","nucleic acid binding activity;other molecular function","THAP9","ENSG00000168152","","","",73.7,70.5,66,43.6,42.7,54,1.4982181040627225,0.583247660342279,5.4296292423800345E-3,2.2652298248284346,0.044719984308547796,1.3494983575078652,948]
["High","Q9H6A9-1","Pecanex-like protein 3 [OS=Homo sapiens]",3,3,4,3,2034,221.9,6.64,8.04,"","other membranes","","PCNX3","ENSG00000197136","","","",290.8,287,274.9,234.1,237.6,240,1.1981171842068286,0.2607690206526729,7.6498855404092206E-4,3.11634506282554,0.01896200199984609,1.7221158119565052,315]
["High","Q9H6E4","Coiled-coil domain-containing protein 134 [OS=Homo sapiens]",20,4,12,4,229,26.5,8.85,30.41,"developmental processes","non-structural extracellular;ER/Golgi;nucleus","","CCDC134","ENSG00000100147","","","",422.6,479.5,414.7,411.5,453.8,418.7,1.0255451713395638,0.03639103841196011,0.6752684704430416,0.17052352783390837,0.7998325572237969,0.09700092186433235,6592]
["High","Q9H6S0","Probable ATP-dependent RNA helicase YTHDC2 [OS=Homo sapiens]",7,6,9,6,1430,160.1,8.4,14.29,"cell cycle OR cell proliferation;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","YTHDC2","ENSG00000047188","","","",253.2,261.5,255,291.2,313.2,289.3,0.8612509790757524,-0.215494377004332,0.006887221067497898,2.1619559767135907,0.05044598695593207,1.297173376745509,1066]
["High","Q9H6S3","epidermal growth factor receptor kinase substrate 8-like protein 2 [OS=Homo sapiens]",6,4,4,4,715,80.6,6.84,8.54,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","cytoskeletal activity","EPS8L2","ENSG00000177106","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",218.5,181.4,195.4,252.3,211.3,236.5,0.850307098985859,-0.23394411226315856,0.09598217236822877,1.017809424888513,0.23317635402959871,0.6323154926572034,3214]
["High","Q9H6Z4-2","Isoform 2 of Ran-binding protein 3 [OS=Homo sapiens]",36,14,47,14,562,59.7,4.81,105.84,"","","","RANBP3","","","","",1973.3,1807.2,1941.7,1847.5,1762.9,1672.9,1.0830730793254215,0.11513059070557793,0.11072656699287697,0.9557481649014634,0.2568487923589969,0.5903224718826331,3366]
["High","Q9H7H0","Methyltransferase-like protein 17, mitochondrial [OS=Homo sapiens]",5,2,2,2,456,50.7,9.33,5.01,"protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus","other molecular function","METTL17","ENSG00000165792","","","",119.6,52.3,56.7,64.9,67.5,66.1,1.1516372795969771,0.20368639618415785,0.6685524182390454,0.17486453595697726,0.7952555273629596,0.09949330367939747,6564]
["High","Q9H7L9","Sin3 histone deacetylase corepressor complex component SDS3 [OS=Homo sapiens]",16,5,8,5,328,38.1,5.66,18.91,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","SUDS3","ENSG00000111707","","Ub-specific processing proteases; NoRC negatively regulates rRNA expression; HDACs deacetylate histones; Potential therapeutics for SARS","",190.8,185,203.1,268.5,218.9,202.2,0.8394721577726219,-0.2524456178602193,0.14791079961062256,0.8300001151169036,0.3082165794928585,0.5111440035520662,3747]
["Medium","Q9H816","5' exonuclease Apollo [OS=Homo sapiens]",2,1,1,1,532,60,8.41,0,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DCLRE1B","ENSG00000118655","","Fanconi Anemia Pathway","",82.8,75.5,74.5,80.2,80.1,84.7,0.9502040816326531,-0.07369069098164895,0.24987916559818088,0.6022699529289564,0.43251086787643456,0.3640029753680314,4511]
["High","Q9H8E8-1","Cysteine-rich protein 2-binding protein [OS=Homo sapiens]",9,6,6,6,782,88.8,6.57,14.23,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","KAT14","ENSG00000149474","","HATs acetylate histones","",257.6,273.8,254.3,241.2,283.6,247.6,1.0172190574831697,0.024630396121102533,0.7751572116483108,0.11061020816820284,0.8691021695218281,0.06092916595486101,6964]
["High","Q9H8G2-1","Caspase activity and apoptosis inhibitor 1 [OS=Homo sapiens]",25,6,14,6,361,38.3,4.72,35.38,"other biological processes","","","CAAP1","ENSG00000120159","Acute viral myocarditis","","",330.6,318.6,349.8,362.4,370.2,383.9,0.8947604120017912,-0.16042666803005529,0.023899501292378895,1.6216111613208015,0.09800803891328488,1.0087383007106216,1904]
["Medium","Q9H8M1","Coenzyme Q-binding protein COQ10 homolog B, mitochondrial [OS=Homo sapiens]",3,1,1,1,238,27.1,9.6,2.33,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ10B","ENSG00000115520","","Respiratory electron transport","",118.7,116.4,120,97.4,96.3,95.5,1.2278699861687414,0.2961578080698539,5.0326554918168205E-5,4.298202798020072,0.006337899045178344,2.1980546828596905,62]
["High","Q9H900-1","Protein zwilch homolog [OS=Homo sapiens]",25,11,21,11,591,67.2,6.27,32.56,"cell cycle OR cell proliferation;signal transduction;other biological processes","cytosol;other cell component","","ZWILCH","ENSG00000174442","","RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",746.7,771.7,767.3,789.5,839.8,784.8,0.9468124766993912,-0.07884937745685087,0.08986755391265858,1.0463970791248938,0.2239661222311006,0.6498176693479636,3133]
["High","Q9H920","RING finger protein 121 [OS=Homo sapiens]",5,1,1,1,327,37.9,7.06,3.13,"protein metabolism;other metabolic processes;stress response;signal transduction","other membranes;ER/Golgi","other molecular function","RNF121","ENSG00000137522","","","",16.5,20.4,18.6,15.6,19.6,23.4,0.9470989761092149,-0.07841289318477974,0.7025752604210302,0.1533071469604411,0.8201087805901337,0.086128538254439,6689]
["High","Q9H9B1","histone-lysine N-methyltransferase EHMT1 [OS=Homo sapiens]",28,24,47,23,1298,141.4,5.76,99.5,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","EHMT1","ENSG00000181090","Histone modifications; MTHFR deficiency","Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; Senescence-Associated Secretory Phenotype (SASP); Regulation of TP53 Activity through Methylation; Transcriptional Regulation by VENTX","Lysine degradation; Metabolic pathways; Longevity regulating pathway",1361.5,1390.9,1375,1577.5,1467.8,1601.3,0.8882623854000774,-0.17094219511279826,0.014581865789699494,1.8361869032931828,0.0736926913177823,1.132575582395401,1545]
["High","Q9H9C1-1","Spermatogenesis-defective protein 39 homolog [OS=Homo sapiens]",31,13,18,13,493,57,7.4,40.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","C14orf133; VIPAS39","ENSG00000151445; ENSPTRG00000006581","","","",696.2,731,712.3,748.3,721.8,696.6,0.9874463469792774,-0.018225733596123648,0.6408932183993338,0.19321432387127743,0.7755880733512086,0.11036887792956597,6452]
["High","Q9H9J4-2","Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 42 [OS=Homo sapiens]",10,10,15,10,1316,144.2,8.47,24.71,"","","","USP42","","","","",548.9,521.1,558.5,544.3,498.7,527.3,1.0370629815958736,0.05250351274022523,0.3273566049724428,0.4849788920288446,0.5143892879100087,0.28870808411574195,4969]
["High","Q9H9Z2","Protein lin-28 homolog A [OS=Homo sapiens]",66,13,106,11,209,22.7,8.07,240.43,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","LIN28A","ENSG00000131914","Cardiac progenitor differentiation; CCL18 signaling pathway","Transcriptional regulation of pluripotent stem cells","",3913.6,4214.4,4195,4075.2,4508.2,4277.4,0.9581830057228167,-0.061626868744169325,0.32102172190291894,0.4934655801078953,0.508116279063043,0.2940368909114011,4933]
["Medium","Q9HAB3","Solute carrier family 52, riboflavin transporter, member 2 [OS=Homo sapiens]",2,1,1,1,445,45.7,7.15,1.63,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC52A2","ENSG00000185803; ENSG00000285112","","Vitamin B2 (riboflavin) metabolism","",48.1,39.3,47.2,47.8,38.5,40.9,1.058176100628931,0.08157973932596194,0.5659544779880247,0.24721849947192934,0.7191167720310003,0.1432005820357668,6145]
["High","Q9HAS0","Protein Njmu-R1 [OS=Homo sapiens]",26,6,7,6,396,44.6,5.03,15.59,"cell organization and biogenesis;transport","ER/Golgi;other cell component","","C17orf75","ENSG00000108666","","","",213.6,214.4,211.5,216.6,208.5,210.5,1.0061359345500314,0.0088252344204801,0.6414615019749073,0.1928294031730293,0.7756746797924851,0.11032038492023341,6457]
["High","Q9HAV7","GrpE protein homolog 1, mitochondrial [OS=Homo sapiens]",41,10,16,10,217,24.3,8.12,27.2,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","GRPEL1","ENSG00000109519","","Mitochondrial protein import","",1190.4,939,1174.5,1081.8,757.8,729.9,1.2858143607705779,0.3626823688493422,0.1533388009898079,0.8143479369683068,0.3149051441684429,0.5018202448390958,3802]
["High","Q9HB09-1","Bcl-2-like protein 12 [OS=Homo sapiens]",17,5,8,5,334,36.8,9.22,16.21,"other biological processes","nucleus","","BCL2L12","ENSG00000126453","Regulation of apoptosis by parathyroid hormone-related protein","","",366.3,381.1,391.6,297,290.4,283.3,1.3081428735500171,0.38752011859244967,4.2795856617465825E-4,3.368598276203583,0.01505180398509789,1.8224114459955865,222]
["High","Q9HBE1-1","POZ-, AT hook-, and zinc finger-containing protein 1 [OS=Homo sapiens]",5,3,8,2,687,74,8.35,21.19,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PATZ1; ZNF278","ENSANAG00000029603; ENSCCAG00000028772; ENSCJAG00000010978; ENSG00000100105; ENSSBOG00000003894","Androgen receptor signaling pathway","","",124.3,120.7,123.8,135.7,139.9,127.1,0.9158182269679661,-0.1268668165164163,0.04528500154008207,1.3440456131514489,0.1444384362847062,0.8403172219663371,2448]
["High","Q9HBL8","NmrA-like family domain-containing protein 1 [OS=Homo sapiens]",10,3,7,3,299,33.3,7.52,12.91,"","cytosol;nucleus;other cell component","other molecular function","NMRAL1","ENSG00000153406; ENSG00000274684","","Urea cycle","",298.9,295.3,337.3,316.3,321.8,302.9,0.98990435706695,-0.01463895378689922,0.8385247076815379,0.07648413609705863,0.9073172003294688,0.04224085597230859,7216]
["High","Q9HC07","Transmembrane protein 165 [OS=Homo sapiens]",22,4,12,4,324,34.9,7.02,39.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","TMEM165","ENSG00000134851","IL-18 signaling pathway","","",376,352.4,383.3,402.2,407.6,429.2,0.8972558514931396,-0.15640866821674568,0.0270656638747341,1.5675813159367586,0.10513865847458899,0.9782375686986122,2010]
["Low","Q9HC96","Calpain-10 [OS=Homo sapiens]",1,1,1,1,672,74.9,7.74,1.79,"cell organization and biogenesis;protein metabolism;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","CAPN10","ENSG00000142330","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",43.2,46.3,43.8,54.7,54,55.1,0.8137973137973138,-0.2972585765520355,5.3169661229770756E-4,3.2743361067821146,0.016539789437531874,1.7814700236045171,251]
["High","Q9HCE3","Zinc finger protein 532 [OS=Homo sapiens]",16,15,26,14,1301,141.6,8.65,48.84,"","nucleus","nucleic acid binding activity;other molecular function","ZNF532","ENSG00000074657","","","",719.6,691,688.8,983,960.3,959,0.7233573372842227,-0.4672195827431324,2.9181902276461886E-5,4.534886401227938,0.005063384288324765,2.2955591103446467,45]
["High","Q9HCJ3","Ribonucleoprotein PTB-binding 2 [OS=Homo sapiens]",3,2,3,2,691,74.3,7.47,2.09,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RAVER2","ENSG00000162437","","","",128.5,160.1,134.6,130.8,201,199.4,0.7966867469879518,-0.32791551923289897,0.22451097313140642,0.648762427694258,0.4048456531662867,0.39271051938898804,4330]
["High","Q9HCP0-1","Casein kinase I isoform gamma-1 [OS=Homo sapiens]",11,4,5,2,422,48.5,9.01,8.29,"cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK1G1","ENSG00000169118; ENSMFAG00000002355; ENSMMUG00000021124; ENSMNEG00000044820; ENSPPYG00000006548; ENSRROG00000038647","Wnt signaling pathway; Hedgehog signaling pathway","","Hedgehog signaling pathway",54.6,48.2,54.3,29.5,36.8,32.2,{"$f":"AVERAGE(T6594:V6594)/AVERAGE(W6594:Y6594)","v":1.5949238578680205},{"$f":"LOG(Z6594,2)","v":0.6734875509504579},{"$f":"TTEST(T6594:V6594,W6594:Y6594,2,2)","v":0.002806272954201576},{"$f":"-LOG10(AB6594)","v":2.551870089281177},{"$f":"AB6594*7808/AF6594","v":0.03236540506116087},{"$f":"-LOG10(AD6594)","v":1.489918953307686},677]
["High","Q9HD20","manganese-transporting ATPase 13A1 [OS=Homo sapiens]",16,17,38,17,1204,132.9,8.13,79.63,"transport;other biological processes","other membranes;ER/Golgi","transporter activity;other molecular function","ATP13A1","ENSG00000105726","","Ion transport by P-type ATPases","",1468.6,1359.4,1482.4,1321.7,1324.2,1410.3,1.0626694936147132,0.08769296651673557,0.15619404926475045,0.8063355160458611,0.31925736561758417,0.49585907429893433,3820]
["High","Q9HD42-1","Charged multivesicular body protein 1a [OS=Homo sapiens]",16,5,10,5,196,21.7,8.06,18.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CHMP1A","ENSG00000131165; ENSPPAG00000031215; ENSPPYG00000007667","","HCMV Late Events","Endocytosis; Necroptosis",638,511.8,612.3,603.8,538.7,552.3,1.0397097002596178,0.05618076638618482,0.6318028188246011,0.19941844079674706,0.7678002193591417,0.1147517681414438,6425]
["High","Q9NNW7-1","thioredoxin reductase 2, mitochondrial [OS=Homo sapiens]",19,6,8,5,524,56.5,7.5,22.01,"stress response;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","TXNRD2","ENSG00000184470","Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Oxidative stress response; 22q11.2 copy number variation syndrome","Detoxification of Reactive Oxygen Species","Selenocompound metabolism; Pathways in cancer; Hepatocellular carcinoma",226.5,239.4,221,239.6,239.7,254.4,0.9362137113261553,-0.09509020067984286,0.10080903257821357,0.9965005529785179,0.24166930499560685,0.6167785068847557,3257]
["High","Q9NP73-1","Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 [OS=Homo sapiens]",8,6,6,6,1137,126,6.74,8.65,"protein metabolism","other membranes;ER/Golgi","other molecular function","ALG13","ENSG00000101901","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG14 causes ALG14-CMS","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways",69.9,90.5,77.4,87,131.7,104.5,0.7357673267326732,-0.4426784830061391,0.11792477067316065,0.9283949596485334,0.26758401901076384,0.5725398276108281,3441]
["Medium","Q9NP87","DNA-directed DNA/RNA polymerase mu [OS=Homo sapiens]",2,1,1,1,494,54.8,8.41,2.27,"DNA metabolism;other metabolic processes;stress response","nucleus","nucleic acid binding activity;other molecular function","POLM","ENSG00000122678","Non-homologous end joining; DNA repair pathways, full network","Nonhomologous End-Joining (NHEJ)","Non-homologous end-joining",30.3,24.9,25.1,20.1,34.3,24,1.024234693877551,0.03454633340210633,0.8969164120349955,0.04724802906680194,0.9412800195119954,0.026281159954045206,7440]
["Medium","Q9NPE2-2","Neugrin [OS=Homo sapiens]",3,1,1,1,291,32.4,9.1,2.4,"developmental processes;other biological processes","non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus","nucleic acid binding activity","NGRN","ENSG00000182768","","","",32.4,33,39.6,35,29.9,27.4,1.1375947995666305,0.18598677490771065,0.2580039229956557,0.5883736904615259,0.44148468786984,0.35508435457555126,4563]
["High","Q9NPH2","Inositol-3-phosphate synthase 1 [OS=Homo sapiens]",24,12,52,12,558,61,5.76,130.48,"other metabolic processes","cytosol;other cell component","other molecular function","ISYNA1","ENSG00000105655","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways",1814.2,1794.9,1776.6,1564.4,1532.6,1571.4,1.153650072830092,0.2062056895387135,1.207734406589026E-4,3.9180285611078953,0.009155330336550598,2.0383259811544323,103]
["High","Q9NPJ8","NTF2-related export protein 2 [OS=Homo sapiens]",21,3,6,1,142,16.2,5.48,4.31,"transport","cytosol;nucleus;other cell component","","NXT2","ENSG00000101888","","","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; mRNA surveillance pathway; Amyotrophic lateral sclerosis; Influenza A",122.7,125.6,125.5,112.9,116.2,101.7,1.129987908101572,0.17630733457388345,0.033138207429972276,1.4796709879000003,0.11912666833021342,0.9239910041581743,2172]
["High","Q9NQ66-1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [OS=Homo sapiens]",4,3,3,3,1216,138.5,6.23,2.5,"cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PLCB1","ENSG00000182621; ENSPPAG00000023075; ENSPTRG00000013241","AMP-activated protein kinase (AMPK) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; S1P receptor signal transduction; Cell-type dependent selectivity of CCK2R signaling; Chemokine signaling pathway; GPR40 pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; Fragile X syndrome; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; Alzheimer's disease","Ca2+ pathway; Synthesis of IP3 and IP4 in the cytosol; G alpha (q) signalling events; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Inositol phosphate metabolism; Metabolic pathways; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Apelin signaling pathway; Gap junction; Platelet activation; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Pathways in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis",11.5,17.6,11.7,13.1,12.1,12.8,1.0736842105263158,0.10256973364054776,0.6684596244272647,0.1749248193937599,0.7952663031430874,0.09948741899204763,6563]
["High","Q9NQC3","Reticulon-4 [OS=Homo sapiens]",46,30,150,22,1192,129.9,4.5,322.61,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","RTN4","ENSG00000115310","Alzheimer's disease and miRNA effects; Spinal cord injury; 22q11.2 copy number variation syndrome; Alzheimer's disease","Axonal growth inhibition (RHOA activation)","Alzheimer disease",3014.8,3119.7,3131.1,3013.1,2776.6,2854.9,1.0718367535802698,0.10008519242408692,0.05836098882566467,1.2338773583500109,0.16821063150638232,0.7741465587245439,2709]
["High","Q9NQG6","Mitochondrial dynamics protein MID51 [OS=Homo sapiens]",8,4,5,4,463,51.3,7.64,8.82,"cell organization and biogenesis;stress response;other biological processes","other membranes;mitochondrion","other molecular function","MIEF1","ENSG00000100335","","","",249.9,237.9,246.5,242.6,213.9,227.6,1.0733810846367489,0.10216236995064597,0.13731290828004766,0.8622886344217455,0.29478668898834537,0.5304921308178221,3637]
["High","Q9NQT5","exosome complex component RRP40 [OS=Homo sapiens]",36,5,15,5,275,29.6,8.1,39.12,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","EXOSC3","ENSG00000107371","","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","RNA degradation",428.9,422.6,403.9,473.8,501,448.6,0.8819727413235914,-0.1811940270467243,0.029501434197035614,1.5301568705059665,0.11079711313634155,0.9554715551788002,2079]
["High","Q9NQY0-1","Bridging integrator 3 [OS=Homo sapiens]",16,3,3,3,253,29.6,7.47,8.77,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","other molecular function","BIN3","ENSG00000147439; ENSGGOG00000002428; ENSPPAG00000028325; ENSPTRG00000020066","","","",169.7,160.7,177.9,187.7,189.7,196.4,0.8858487277797141,-0.17486773732022007,0.017773984140280197,1.7502152116883898,0.08325091071824102,1.0796110068577596,1667]
["High","Q9NR19-1","Acetyl-coenzyme A synthetase, cytoplasmic [OS=Homo sapiens]",5,4,9,3,701,78.5,6.46,19.43,"other metabolic processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","ACSS2","ENSG00000131069","Fatty acid beta-oxidation; Fatty acid biosynthesis; Lipid metabolism pathway; Ethanol effects on histone modifications; Fluoroacetic acid toxicity; Amino acid conjugation of benzoic acid","Transcriptional activation of mitochondrial biogenesis; Ethanol oxidation","Glycolysis / Gluconeogenesis; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism",366,338.7,330,395.1,384.7,408.8,0.8705199394245332,-0.20005075142863266,0.016429900606015922,1.7843650638558322,0.07948244357606711,1.0997287895832484,1614]
["High","Q9NR45","sialic acid synthase [OS=Homo sapiens]",49,13,69,13,359,40.3,6.74,117.51,"other metabolic processes","cytosol;other cell component","other molecular function","NANS","ENSG00000095380","","Sialic acid metabolism","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",1922.3,1823.3,1874.8,1803.6,1802.8,1853.1,1.0294715633299751,0.04190397954818217,0.18020795018143432,0.7442260532916694,0.3508012154117774,0.45493891061468084,4011]
["High","Q9NRF8","CTP synthase 2 [OS=Homo sapiens]",37,19,50,15,586,65.6,6.9,98.28,"other metabolic processes","cytosol;other cell component","other molecular function","CTPS2","ENSG00000047230","Pyrimidine metabolism","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",1874.2,1962.9,1877.6,1878,2064.6,2035,0.9560191381156318,-0.06488859573138936,0.2474412625735048,0.6065278770037976,0.43010271108057113,0.36642781993458234,4492]
["High","Q9NRG9-1","Aladin [OS=Homo sapiens]",37,14,30,14,546,59.5,7.5,74.13,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus","","AAAS","ENSG00000094914","","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; RHOA GTPase cycle; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; Regulation of HSF1-mediated heat shock response; Vpr-mediated nuclear import of PICs; Viral Messenger RNA Synthesis; tRNA processing in the nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Ribonucleoproteins into the Host Nucleus; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)","Nucleocytoplasmic transport",1127.2,1130.8,1163.4,1093.8,1229.3,1172.7,0.9787173179243664,-0.031035867253209035,0.5773969351329098,0.23852552571750424,0.727264924910108,0.1383073574104424,6199]
["High","Q9NRN9","Methyltransferase-like protein 5 [OS=Homo sapiens]",16,2,7,2,209,23.7,6.68,4.94,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","METTL5","ENSG00000138382","","","",22.4,39.4,38.8,30.6,50.4,42.7,0.813257881972514,-0.29821519517084283,0.3910582708574316,0.4077585243783227,0.5748085427061043,0.24047678607964842,5312]
["High","Q9NRV9","Heme-binding protein 1 [OS=Homo sapiens]",66,11,41,11,189,21.1,5.8,79.41,"other biological processes","non-structural extracellular;other cell component","other molecular function","HEBP1","ENSG00000013583","","G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands","",1921.5,1918.2,1991.1,1773.3,1827.1,1773.1,1.0851028193914578,0.11783175234539661,0.00690540377844399,2.1608109219190683,0.050296075281801,1.2984659026171839,1072]
["High","Q9NRX2","39S ribosomal protein L17, mitochondrial [OS=Homo sapiens]",9,2,3,2,175,20,10.11,7.03,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL17","ENSG00000158042","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",330.5,257.6,304.6,301.9,240,240.9,1.1403934593765968,0.18953166996548668,0.28323776566273323,0.5478488402286112,0.46903933707202994,0.328790732643323,4715]
["High","Q9NS69","Mitochondrial import receptor subunit TOM22 homolog [OS=Homo sapiens]",51,4,34,4,142,15.5,4.34,103.23,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity","TOMM22","ENSG00000100216","","PINK1-PRKN Mediated Mitophagy; Mitochondrial protein import","",1068.4,1112.8,1072.1,991.5,1037.9,1031,1.0630309763429615,0.08818363709973476,0.033833451142206324,1.4706537002441928,0.12057123985319351,0.9187562731462627,2191]
["High","Q9NS91","E3 ubiquitin-protein ligase RAD18 [OS=Homo sapiens]",16,6,13,6,495,56.2,7.58,36.28,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD18","ENSG00000070950","SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Recognition of DNA damage by PCNA-containing replication complex; E3 ubiquitin ligases ubiquitinate target proteins","",812.2,814,774.4,777.2,848.4,820.3,0.9814792101067092,-0.02697038633357559,0.5695237436308593,0.24448816532867376,0.7213043617631386,0.14188144160178884,6165]
["High","Q9NSG2-1","Uncharacterized protein C1orf112 [OS=Homo sapiens]",3,2,4,2,853,96.5,6,2.5,"","","","C1orf112","ENSG00000000460","","","",85.8,78.6,77.8,83.5,83.5,99.5,0.9088180112570357,-0.13793666795220946,0.24232039768708297,0.6156100269269177,0.424604502949,0.37201540443395475,4456]
["High","Q9NSV4-3","Protein diaphanous homolog 3 [OS=Homo sapiens]",9,8,12,8,1193,136.8,7.03,20.5,"cell organization and biogenesis","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","DIAPH3","ENSG00000139734","Regulation of actin cytoskeleton","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; RHOC GTPase cycle; RHO GTPases Activate Formins; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","Regulation of actin cytoskeleton",361.3,317,353.4,282.5,299.9,297,1.1731862633613825,0.2304320840352996,0.025778122516840404,1.588748716550825,0.10279651716623589,0.9880215993593084,1958]
["High","Q9NTK5-1","obg-like ATPase 1 [OS=Homo sapiens]",71,23,115,10,396,44.7,7.81,241.2,"other metabolic processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","translation activity;other molecular function","LOC111144733; Ola1; OLA1","ENSCCAG00000017844; ENSFCAG00000036661; ENSG00000138430; ENSLCNG00005010543; ENSMMUG00000007092; ENSMNEG00000040767; ENSMPUG00000013906; ENSNVIG00000008347; ENSPTRG00000012650; ENSRROG00000038551","","Platelet degranulation","",6341.1,6091.6,6153.9,6522.4,6300.6,6383.2,0.9677395840926367,-0.04730922020110397,0.10538956377415408,0.9772023931054468,0.24837962992713403,0.6048840243287713,3313]
["High","Q9NTX7","E3 ubiquitin-protein ligase rnf146 [OS=Homo sapiens]",11,3,3,3,359,38.9,5.33,7.74,"cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RNF146","ENSG00000118518","","Ub-specific processing proteases; Degradation of AXIN; Regulation of PTEN stability and activity","",182.3,171.4,181.2,151.9,167.6,155,1.1272918861959962,0.17286111643767987,0.02726043578947184,1.5644672057482232,0.10558010051795444,0.9764179288630754,2016]
["High","Q9NUI1","Peroxisomal 2,4-dienoyl-CoA reductase [OS=Homo sapiens]",12,3,4,3,292,30.8,9.22,10.7,"other metabolic processes","other membranes;cytosol;other cytoplasmic organelle","other molecular function","DECR2","ENSG00000242612; ENSG00000274296","","Peroxisomal protein import; Beta-oxidation of very long chain fatty acids","Peroxisome",193.1,204.9,180.8,161.7,178.7,183.2,1.105423987776929,0.14459982458648385,0.12639555522589652,0.8982681980062195,0.27989123516840614,0.5530107013108874,3526]
["High","Q9NUQ3-1","Gamma-taxilin [OS=Homo sapiens]",35,16,29,16,528,60.5,7.52,53.28,"cell cycle OR cell proliferation;other biological processes","other membranes;cytosol;nucleus","other molecular function","TXLNG","ENSG00000086712","","","",992,896.9,962.2,954.4,869.7,834.6,1.072366194004589,0.10079764465813945,0.22986942881696917,0.6385187833150102,0.4101509369750675,0.3870562919817491,4376]
["High","Q9NUQ6","SPATS2-like protein [OS=Homo sapiens]",4,3,4,3,558,61.7,9.64,2.15,"","cytosol;nucleus;other cell component","","SPATS2L","ENSG00000196141","","","",208.7,224.1,222,300.5,317.1,308.9,0.7067458175930923,-0.5007366544404747,1.8350706706981662E-4,3.7363472059060348,0.01102171676677791,1.957750753554236,130]
["High","Q9NUY8","TBC1 domain family member 23 [OS=Homo sapiens]",14,7,14,7,699,78.3,5.41,30.47,"cell organization and biogenesis;transport;developmental processes","cytosol;ER/Golgi;other cell component","","TBC1D23","ENSG00000036054","","","",231.2,217.8,224.6,267,301,279.7,0.7946207384687979,-0.3316616486855368,0.005503474803625641,2.2593630174996995,0.044995948970375926,1.3468265844248104,955]
["High","Q9NVA2-1","Septin-11 [OS=Homo sapiens]",40,17,85,7,429,49.4,6.81,191.24,"cell cycle OR cell proliferation;other biological processes","cytoskeleton;other cell component","other molecular function","Sept11; SEPT11; SEPTIN11","ENSANAG00000029750; ENSBTAG00000021372; ENSCATG00000027299; ENSCCAG00000022420; ENSCHIG00000021075; ENSCSAG00000004591; ENSFCAG00000027412; ENSG00000138758; ENSLCNG00005000771; ENSMFAG00000042066; ENSMMUG00000019901; ENSMNEG00000044831; ENSNLEG00000032040; ENSPCTG00005005661; ENSPPAG00000041700; ENSPTRG00000016192; ENSRBIG00000024343; ENSRROG00000038768; ENSSBOG00000020488; ENSSSUG00005020042; ENSUAMG00000017287","22q11.2 copy number variation syndrome","","Bacterial invasion of epithelial cells; Shigellosis",4862.9,4912.1,4946.4,5311.2,5342.6,5431.1,0.9152310552132745,-0.12779208905377945,4.6614872836835548E-4,3.3314754961762914,0.015357338696624976,1.8136840375277596,237]
["High","Q9NVF7-1","F-box only protein 28 [OS=Homo sapiens]",24,8,10,8,368,41.1,9.55,27.6,"protein metabolism;other metabolic processes","other cell component","other molecular function","FBXO28","ENSG00000143756; ENSGGOG00000010974; ENSPPAG00000034613; ENSPTRG00000002021","","","",412.9,365.1,385.1,396.3,359.6,395.8,1.0098984110445428,0.01421017490423096,0.8467312240553755,0.07225442489242737,0.9127816370874461,0.03963310543450771,7243]
["High","Q9NVI1-3","Fanconi anemia group I protein [OS=Homo sapiens]",30,35,82,35,1328,149.2,6.74,164.89,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","FANCI","ENSG00000140525","Gastric cancer network 2; DNA repair pathways, full network","TP53 Regulates Transcription of DNA Repair Genes; Fanconi Anemia Pathway","Fanconi anemia pathway",3529.2,3583,3585.7,3704.2,3794.7,3855.3,0.9421976008877772,-0.08589843640276895,0.010063411195874492,1.9972547814639228,0.061052925110635606,1.214293523709674,1287]
["High","Q9NVM4","Protein arginine N-methyltransferase 7 [OS=Homo sapiens]",15,7,9,7,692,78.4,5.57,20.75,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","PRMT7","ENSG00000132600","Nitric oxide metabolism in cystic fibrosis","RMTs methylate histone arginines","",257.7,227.1,236.5,224.8,213.2,218.3,1.0990400731372847,0.1362439907115551,0.0881582672503563,1.0547369544610306,0.22168752035129854,0.6542587543149941,3105]
["High","Q9NVN3-1","Isoform 1 of Synembryn-B [OS=Homo sapiens]",12,4,7,4,536,60.8,5.88,11.38,"","","","RIC8B","","","","",227.3,237.5,203.2,201.6,168.2,171.9,1.2331548827764447,0.30235401189036215,0.045459332006291105,1.3423769502237441,0.14469892552185934,0.8395346937714944,2453]
["High","Q9NVS2","39S ribosomal protein S18a, mitochondrial [OS=Homo sapiens]",17,3,3,3,196,22.2,10.33,4.29,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS18A","ENSG00000096080","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",176.4,151.5,187.4,243.4,199.6,189.6,0.8145747707872272,-0.295880963364365,0.11733030371517794,0.930589805134436,0.2667778134560598,0.5738502913006984,3434]
["High","Q9NVX7-1","Kelch repeat and BTB domain-containing protein 4 [OS=Homo sapiens]",3,1,1,1,518,58.1,5.67,3.94,"","","","KBTBD4","ENSG00000123444; ENSG00000284900","","","",17.4,18.3,20.5,24.8,21.8,18.2,0.867283950617284,-0.20542368266369848,0.24741431350074675,0.6065751790214717,0.43024742980263486,0.3662817153661595,4490]
["High","Q9NVZ3","Adaptin ear-binding coat-associated protein 2 [OS=Homo sapiens]",28,6,14,6,263,28.3,8.38,33.44,"transport","plasma membrane;other membranes","","NECAP2","ENSG00000157191","","Cargo recognition for clathrin-mediated endocytosis","",696,767.7,681.2,630.4,689.2,610,1.111577529021559,0.1526085752962748,0.11503641463910334,0.939164662485515,0.26301737203575953,0.580015565844431,3415]
["High","Q9NW82","WD repeat-containing protein 70 [OS=Homo sapiens]",19,11,15,11,654,73.2,6.33,24.47,"other biological processes","nucleus;other cell component","other molecular function","WDR70","ENSG00000082068","","","",649.4,647.1,599.5,653.7,622.2,608.8,1.005995649174935,0.008624065653063624,0.8664605533781661,0.062251204260105567,0.9232156114597053,0.034696860261264145,7328]
["High","Q9NWM8","Peptidyl-prolyl cis-trans isomerase FKBP14 [OS=Homo sapiens]",7,1,2,1,211,24.2,6.07,2.62,"protein metabolism;other metabolic processes","ER/Golgi","other molecular function","FKBP14","ENSG00000106080","","XBP1(S) activates chaperone genes","",32.7,27.8,45.1,33.6,32.9,28.1,1.1162790697674418,0.15869774601905823,0.5365733722419521,0.27037088323941166,0.6976794155645566,0.15634409031970112,6005]
["High","Q9NWQ9","Uncharacterized protein C14orf119 [OS=Homo sapiens]",14,2,2,2,140,16,4.94,1.73,"","cytosol;mitochondrion","","C14orf119","ENSG00000179933","","","",113.9,91.2,102.6,91.1,90.4,85.2,1.1537307836520436,0.2063066187826188,0.11529247040676152,0.9381990549565908,0.2632944161848476,0.57955835109455,3419]
["High","Q9NWX5","Ankyrin repeat and SOCS box protein 6 [OS=Homo sapiens]",7,2,2,2,421,47.1,6.01,7.64,"protein metabolism;other metabolic processes;signal transduction","cytosol","","ASB6","ENSG00000148331","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",133.3,108.2,105.2,87.3,91.2,80.4,1.3391270760911549,0.4212928713027222,0.0363481504916668,1.4395176825132918,0.1264734220316107,0.8980007304387801,2244]
["High","Q9NWZ5-1","Uridine-cytidine kinase-like 1 [OS=Homo sapiens]",11,6,9,6,548,61.1,7.36,8.55,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","UCKL1","ENSG00000198276; ENSPPAG00000038781","Pyrimidine metabolism","Pyrimidine salvage","Pyrimidine metabolism; Drug metabolism; Metabolic pathways",256.4,278.9,267.7,292.2,312.6,299.1,0.8883726075893351,-0.1707631859109425,0.018999993452200152,1.7212465487142148,0.08620101619684997,1.0644876143831397,1721]
["High","Q9NX24","H/ACA ribonucleoprotein complex subunit 2 [OS=Homo sapiens]",18,2,4,2,153,17.2,8.22,11.53,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","NHP2","ENSG00000145912","","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","Ribosome biogenesis in eukaryotes",64.9,66.9,83.4,100.2,77.5,79.5,0.8367029548989113,-0.2572125647713232,0.20779774569305587,0.6823591682243509,0.38483984781104846,0.4147199657702057,4216]
["High","Q9NX61","Transmembrane protein 161A [OS=Homo sapiens]",3,1,2,1,479,53.6,8.44,7.7,"stress response;other biological processes","other membranes","","TMEM161A","ENSG00000064545","","","",45,57,39.6,41.4,53.7,56.6,0.9334212261041529,-0.09939982016403609,0.6529165818675944,0.18514230164802656,0.783941668648651,0.10571625099728972,6503]
["Medium","Q9NX76","CKLF-like MARVEL transmembrane domain-containing protein 6 [OS=Homo sapiens]",5,1,4,1,183,20.4,5.29,5.8,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","","CMTM6","ENSG00000091317","","Neutrophil degranulation","",59.8,65.6,61.5,47.5,50.5,49.8,1.2645466847090658,0.3386202995990066,2.5824600051466465E-3,2.587966395724554,0.03135901667213844,1.5036375639901405,643]
["High","Q9NXF1","Testis-expressed protein 10 [OS=Homo sapiens]",15,13,34,13,929,105.6,9.36,68.49,"","mitochondrion;nucleus","","TEX10","ENSG00000136891","","Major pathway of rRNA processing in the nucleolus and cytosol","",1080.4,982.4,1067,1151.1,1066.3,1164.5,0.9254561045566102,-0.11176353184751074,0.12512115895658857,0.9026692415371037,0.2780153697020613,0.5559311940377445,3514]
["High","Q9NXN4-1","Ganglioside-induced differentiation-associated protein 2 [OS=Homo sapiens]",9,3,3,3,497,56.2,5.74,4.92,"other biological processes","","","GDAP2","ENSG00000196505","","","",38.4,36.3,32,31.1,29,30.5,1.1777041942604856,0.23597722077818975,0.05384559728954758,1.2688498012058054,0.1597971963651796,0.7964308446328728,2631]
["High","Q9NXS2","Glutaminyl-peptide cyclotransferase-like protein [OS=Homo sapiens]",2,2,3,2,382,42.9,9.82,6.22,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","QPCTL","ENSG00000011478","","","",232.9,180.4,214.1,178.5,169.9,204.1,1.1355656108597285,0.1834110646774466,0.2479631067225996,0.6056129310233617,0.430626320571632,0.3658994289257309,4496]
["High","Q9NY27","Serine/threonine-protein phosphatase 4 regulatory subunit 2 [OS=Homo sapiens]",60,17,47,17,417,46.9,4.54,107.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP4R2","ENSG00000163605","16p11.2 proximal deletion syndrome","Processing of DNA double-strand break ends","",1543.4,1535.4,1556.5,1770.6,1549,1720.9,0.919611149687531,-0.12090413698547306,0.11565371625919559,0.9368404076410364,0.2640421685823974,0.578326709038536,3420]
["High","Q9NYF3","protein FAM53C [OS=Homo sapiens]",3,1,2,1,392,43.1,8.65,4.74,"transport","nucleus","","FAM53C","ENSG00000120709","","","",28.6,35.9,24.6,30.8,23.1,21.3,1.184840425531915,0.24469276984428467,0.3525182852125104,0.45281835112383084,0.5380107058129948,0.2692090822718117,5116]
["Medium","Q9NYG2-1","Palmitoyltransferase ZDHHC3 [OS=Homo sapiens]",3,1,2,1,299,34.1,8.18,0,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","ZDHHC3","ENSCCAG00000029642; ENSG00000163812","","","",53.8,40.3,51.5,38.3,35.5,46.2,1.2133333333333334,0.2789759497028154,0.17995501735173433,0.7448360402153207,0.3505710517670513,0.4552239484158746,4008]
["High","Q9NYP3-1","Protein downstream neighbor of son [OS=Homo sapiens]",11,4,5,4,566,62.7,8.66,3.66,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction","nucleus;other cell component","","DONSON","ENSG00000159147","","","",132,146,166.3,171.4,175.1,189.3,0.8292273236282195,-0.27016043983237514,0.054865666660987314,1.260699339412784,0.1617791258644218,0.7910775155218107,2648]
["High","Q9NYU1","UDP-glucose:glycoprotein glucosyltransferase 2 [OS=Homo sapiens]",5,7,9,6,1516,174.6,6.89,9.87,"protein metabolism;other metabolic processes;stress response","ER/Golgi;other cell component","other molecular function","UGGT2","ENSG00000102595","","ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",150.1,145.1,141.6,143.7,138.2,155.5,0.9986282578875172,-1.9803641282407584E-3,0.9735426832956964,0.011645002835864823,0.9855336796541938,6.3285295397524895E-3,7713]
["High","Q9NYZ3","G2 and S phase-expressed protein 1 [OS=Homo sapiens]",9,5,8,5,720,76.6,9.39,10.13,"cell cycle OR cell proliferation;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","GTSE1","ENSG00000075218","","The role of GTSE1 in G2/M progression after G2 checkpoint; G2/M Checkpoints","p53 signaling pathway",195.5,206.2,217.2,161,120,127.3,1.5157972079353417,0.6000767543824901,0.00759589213995984,2.1194212107797856,0.052625311294415646,1.2788053221672566,1127]
["High","Q9NZ53-1","Podocalyxin-like protein 2 [OS=Homo sapiens]",2,1,2,1,605,65,4.34,2.38,"cell adhesion","plasma membrane;other membranes;ER/Golgi","other molecular function","PODXL2","ENSG00000114631","","Cytosolic sulfonation of small molecules","",17.4,26.6,16.1,19.8,21.4,21.1,0.9646869983948635,-0.05186717231281653,0.8370099009467011,0.07726940472945683,0.9069349578950655,0.04242385785737114,7206]
["High","Q9NZ72","Stathmin-3 [OS=Homo sapiens]",13,3,3,2,180,21,7.49,5.11,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","STMN3","ENSG00000197457","","","",104.4,115.7,99.1,99.4,113.9,93.2,1.041435562805873,0.05857357764420213,0.618206249848678,0.2088666086854066,0.7591938343533309,0.11964732760552531,6358]
["High","Q9NZI7","Upstream-binding protein 1 [OS=Homo sapiens]",16,6,15,5,540,60.5,6.35,38.79,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBP1","ENSG00000153560","","","",483.9,549.1,476.5,396.2,476.4,406.4,1.1802189210320564,0.23905449263198825,0.08776437419481797,1.0566817395658545,0.22119568551101962,0.6552233483304063,3098]
["High","Q9NZJ5","Eukaryotic translation initiation factor 2-alpha kinase 3 [OS=Homo sapiens]",14,10,17,10,1116,125.1,5.43,43.91,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","EIF2AK3","ENSG00000172071","Translation factors; Alzheimer's disease and miRNA effects; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; 7q11.23 copy number variation syndrome; Alzheimer's disease","Signaling by ALK fusions and activated point mutants; ALK mutants bind TKIs; PERK regulates gene expression","Mitophagy; Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Hepatitis C; Measles; Herpes simplex virus 1 infection; Lipid and atherosclerosis",617.2,648.9,616.3,552,588.1,584.2,1.0916893811981672,0.126562424067279,0.02826144861877891,1.548805580951085,0.10785209717273986,0.967171405668591,2046]
["High","Q9NZM5","ribosome biogenesis protein NOP53 [OS=Homo sapiens]",15,5,9,5,478,54.4,10.32,18.47,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP53","ENSG00000105373","","","",671.1,233.7,311.6,482.2,288,403.3,1.0365573072006817,0.05179987962026519,0.9267039373919563,0.03305899173882325,0.960151850206528,0.017660076865008784,7536]
["High","Q9NZV5-1","Selenoprotein N [OS=Homo sapiens]",5,3,7,3,590,65.8,5.48,12.9,"cell organization and biogenesis;stress response;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SELENON","ENSG00000162430","Selenium micronutrient network","","",477.5,487.7,467.4,455.3,475,464.1,1.0273952954675845,0.038991372586564495,0.1942553236532896,0.7116270703310852,0.36858944522111425,0.43345710522073844,4115]
["High","Q9P000-1","COMM domain-containing protein 9 [OS=Homo sapiens]",34,4,5,4,198,21.8,5.88,11.85,"transport;other biological processes","non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component","","COMMD9","ENSG00000110442","","Neddylation; Neutrophil degranulation","",336.2,301.1,281.3,318.6,346.4,345.2,0.9093248861611561,-0.13713225821025868,0.1730804274629407,0.7617520408793272,0.3418699665142021,0.46613905056366245,3953]
["High","Q9P0J0","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [OS=Homo sapiens]",43,5,31,5,144,16.7,8.43,47.91,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;mitochondrion;nucleus;other cell component","transporter activity;other molecular function","NDUFA13","ENSG00000186010","Nucleotide-binding oligomerization domain (NOD) pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",815.2,874.7,847.7,770.7,876.5,817.1,1.0297447551028691,0.042286778008693696,0.5249055961193267,0.2799187971103346,0.6880078721671484,0.16240659255054396,5957]
["High","Q9P0N9","TBC1 domain family member 7 [OS=Homo sapiens]",29,6,8,6,293,34,7.94,12.97,"other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","TBC1D7","ENSG00000145979","Fragile X syndrome","TBC/RABGAPs","mTOR signaling pathway",218.3,222.2,188,212.3,220.6,209.6,0.9782101167315176,-0.03178370966073256,0.7009028224210749,0.15434219118005893,0.8185236669853055,0.08696875877797326,6686]
["High","Q9P0S3","ORM1-like protein 1 [OS=Homo sapiens]",20,2,5,2,153,17.4,9.64,11.03,"other metabolic processes;other biological processes","other membranes;ER/Golgi","","ORMDL1","ENSG00000128699","","Sphingolipid de novo biosynthesis","",169.3,193.2,177.3,156.3,167.4,160.5,1.11482858323007,0.15682189746791472,0.07463500956952576,1.1270574071617963,0.19841680446675422,0.7024215490259612,2937]
["High","Q9P1F3","Costars family protein ABRACL [OS=Homo sapiens]",16,1,3,1,81,9.1,6.29,3.27,"other biological processes","","","ABRACL","ENSG00000146386","","","",28.5,18.3,26,33.6,23.4,25.3,0.8845686512758201,-0.17695398022292957,0.5101655732306619,0.29228885160708407,0.6769838198139035,0.16942171100394113,5884]
["High","Q9P1U1-1","Actin-related protein 3B [OS=Homo sapiens]",25,8,34,4,418,47.6,5.88,59.14,"","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTR3B","ENSCANG00000039781; ENSCATG00000043872; ENSCCAG00000019061; ENSCJAG00000019650; ENSCSAG00000006554; ENSG00000133627; ENSMFAG00000034566; ENSMMUG00000018920; ENSMNEG00000033219; ENSPANG00000006816; ENSPPYG00000018206; ENSPTRG00000019897; ENSRROG00000045018","","","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",352.7,395.1,324.6,366.9,355.7,356.8,0.9935149156939043,-0.00938646799007685,0.916078588758602,0.038067267380016395,0.95395327034238,0.020472898806912856,7498]
["High","Q9P219","Protein Daple [OS=Homo sapiens]",7,12,13,12,2028,228.1,6.23,29.23,"cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","CCDC88C","ENSG00000015133","Ectoderm differentiation; Ectoderm differentiation","Negative regulation of TCF-dependent signaling by DVL-interacting proteins","",687.3,703.9,710.2,760.2,734.4,758.8,0.9325463743676223,-0.1007526243112965,9.392397266743787E-3,2.0272235465153403,0.05885701272771709,1.2302017841798556,1246]
["High","Q9P275","Ubiquitin carboxyl-terminal hydrolase 36 [OS=Homo sapiens]",15,14,22,14,1121,122.6,9.67,34.03,"","","","","","","","",997.6,1002.8,1006,1006.6,962.2,923.9,1.0393058388356897,0.05562026179169792,0.18973907498491657,0.7218432210206769,0.36222070843086274,0.4410267243693833,4090]
["High","Q9P2D3-1","HEAT repeat-containing protein 5B [OS=Homo sapiens]",7,9,13,9,2071,224.2,7.17,17.02,"transport;other biological processes","cytosol;other cell component","","HEATR5B","ENSG00000008869","","","",302.3,327,304,314,337.3,323.9,0.9570344544708776,-0.06335723036467418,0.2520110097089906,0.5985804856017268,0.43456315455119227,0.3619470991233064,4528]
["High","Q9P2E5-1","Chondroitin sulfate glucuronyltransferase [OS=Homo sapiens]",8,6,8,6,772,85.9,7.83,9.18,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHPF2","ENSG00000033100; ENSGGOG00000001088","","Chondroitin sulfate biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",555.6,518.3,530.9,513.3,499.6,500.1,1.060674157303371,0.0849815235080813,0.06100583184355216,1.2146286466873997,0.17371755471716094,0.760156292482258,2742]
["High","Q9P2J5","Leucine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",48,52,268,52,1176,134.4,7.3,493.34,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","LARS1","ENSG00000133706","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",9030,9430.5,9070.2,9479,10019.8,9960.1,0.9345460964258678,-0.09766226832212421,0.039449476241173495,1.4039587584134503,0.13316969757504654,0.8755945865254343,2313]
["High","Q9P2L0-1","WD repeat-containing protein 35 [OS=Homo sapiens]",7,5,9,5,1181,133.5,6.38,22.32,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","","WDR35","ENSG00000118965","Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",221.8,196.2,199.3,219,213.9,243.4,0.9127606091971019,-0.1316915623999278,0.1811979325837587,0.7418467618059363,0.3521138520691856,0.4533168895595313,4018]
["High","Q9P2R3","Rabankyrin-5 [OS=Homo sapiens]",16,15,25,14,1169,128.3,6.1,57.1,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ANKFY1","ENSG00000185722","","RHOD GTPase cycle","",956,1034.5,958.1,849.8,905.7,827.2,1.1416734425213924,0.19115004980135267,0.024793365159453174,1.6056645232121958,0.10051225086449136,0.9977810013420761,1926]
["Medium","Q9P2Z0","THAP domain-containing protein 10 [OS=Homo sapiens]",4,1,2,1,257,28.3,8.6,5.18,"","","nucleic acid binding activity;other molecular function","THAP10","ENSG00000129028","","","",133.2,133.7,148.1,128.1,125.5,111.5,1.136674883593536,0.18481966768676497,0.07920486549827828,1.101248139191431,0.20683330762894878,0.6843795228572251,2990]
["High","Q9UBB6","Neurochondrin [OS=Homo sapiens]",37,21,61,21,729,78.8,5.48,142.15,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","NCDN","ENSG00000020129","Splicing factor NOVA regulated synaptic proteins","","",1757,1806.3,1774.1,1543,1578.3,1610.8,1.1279136112930832,0.1736565736481965,1.1551847837368069E-3,2.937348540327295,0.02254920697854247,1.646868726996622,400]
["High","Q9UBF8-2","Isoform 2 of Phosphatidylinositol 4-kinase beta [OS=Homo sapiens]",5,3,3,3,801,89.8,6.44,4.63,"","","","PI4KB","","","","",139.9,116.4,112.7,70.1,59.8,81.5,1.7455061494796598,0.8036454395650757,0.007662503147349109,2.115629334088397,0.052852318528711875,1.2769359562820144,1132]
["High","Q9UBM7","7-dehydrocholesterol reductase [OS=Homo sapiens]",21,10,65,10,475,54.5,8.7,99.19,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","DHCR7","ENSG00000172893","Vitamin D metabolism; Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol","Steroid biosynthesis; Metabolic pathways",2124,2233.9,2232.1,2208.4,2286.8,2263.9,{"$f":"AVERAGE(T7106:V7106)/AVERAGE(W7106:Y7106)","v":0.9749818762853042},{"$f":"LOG(Z7106,2)","v":-0.03655269370340412},{"$f":"TTEST(T7106:V7106,W7106:Y7106,2,2)","v":0.26152298560589143},{"$f":"-LOG10(AB7106)","v":0.5824901343947935},{"$f":"AB7106*7808/AF7106","v":0.4453590995879608},{"$f":"-LOG10(AD7106)","v":0.3512896697421979},4585]
["High","Q9UBP6","tRNA (guanine-N(7)-)-methyltransferase [OS=Homo sapiens]",26,6,13,6,276,31.5,7.64,38.11,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","METTL1","ENSG00000037897","","tRNA modification in the nucleus and cytosol","",599.1,578.2,608.9,681.9,677.4,688.5,0.8722531497216526,-0.1971811928608292,8.1774669686274139E-4,3.0873812014520565,0.019466360393610622,1.7107152405051003,328]
["High","Q9UBQ6","Exostosin-like 2 [OS=Homo sapiens]",14,3,5,3,330,37.4,8.95,5.45,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EXTL2","ENSG00000162694","","XBP1(S) activates chaperone genes","Glycosaminoglycan biosynthesis; Metabolic pathways",252.5,259,263,230.4,290.9,256.2,0.9961414790996784,-5.5774362283964665E-3,0.9578757338232357,0.01869082872455929,0.9774037806706513,0.00992598542118217,7652]
["High","Q9UBU8-2","Isoform 2 of Mortality factor 4-like protein 1 [OS=Homo sapiens]",38,11,34,9,323,37.2,9.19,90.42,"","","","MORF4L1","","","","",1091.6,1040.2,1149.8,1198.4,1120.3,1180.8,0.9377339619945707,-0.0927494111128657,0.1399303845486324,0.8540879723628767,0.297785893310363,0.5260958794601892,3669]
["High","Q9UBV8","Peflin [OS=Homo sapiens]",7,2,12,2,284,30.4,6.54,19.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PEF1","ENSG00000162517","","","",426.8,430.2,431,445.8,433.2,405.9,1.0024126391158845,3.4765103897808495E-3,0.9346805913488756,0.029336775345584747,0.965725295388649,0.015146392904724812,7557]
["High","Q9UDT6-2","Isoform 2 of CAP-Gly domain-containing linker protein 2 [OS=Homo sapiens]",26,25,49,1,1011,111.7,6.83,119.09,"","","","CLIP2","","","","",121.9,119.8,113.1,106.3,118,118.6,1.0347039953339165,0.04921810536542942,0.4553080210762298,0.3416946987397759,0.6327954839023144,0.1987366289466998,5618]
["High","Q9UDY2","Tight junction protein ZO-2 [OS=Homo sapiens]",33,31,97,1,1190,133.9,7.4,182.97,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","TJP2","ENSG00000119139","1q21.1 copy number variation syndrome","Signaling by Hippo; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Apoptotic cleavage of cell adhesion  proteins","Tight junction; Vibrio cholerae infection",4152.6,4201.7,3933.4,4749.9,4445.8,4686,0.8851725653198094,-0.17596935736164881,0.012792017356862358,1.8930609599884922,0.06878792804571715,1.1624877716939317,1452]
["High","Q9UEG4","zinc finger protein 629 [OS=Homo sapiens]",13,7,11,5,869,96.6,7.93,17.83,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF629","ENSG00000102870","","","",193.6,206.3,200.6,219.9,205.6,224.5,0.9238461538461539,-0.11427547221018272,0.07149572633890275,1.1457199174003603,0.1932290173949992,0.7139276545859219,2889]
["High","Q9UG63","ATP-binding cassette sub-family F member 2 [OS=Homo sapiens]",23,15,41,15,623,71.2,7.37,64.83,"transport","","transporter activity;other molecular function","ABCF2","ENSG00000033050","VEGFA-VEGFR2 signaling pathway","","Pathogenic Escherichia coli infection",2418.4,2426.6,2445.1,2501.3,2367.3,2433.1,0.9984113288686196,-2.2937904850289436E-3,0.9266956625447642,0.03306286971578437,0.9602707011479122,0.017606321707799598,7535]
["High","Q9UGN5-1","Poly [ADP-ribose] polymerase 2 [OS=Homo sapiens]",3,2,4,2,583,66.2,8.88,5.13,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP2","ENSG00000129484","NAD+ biosynthetic pathways; Base excision repair; Peroxiredoxin 2 induced ovarian failure; DNA repair pathways, full network","Dual Incision in GG-NER; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; HDR through MMEJ (alt-NHEJ); POLB-Dependent Long Patch Base Excision Repair","Base excision repair; Apoptosis",196.6,197.8,206.9,224.5,232.9,226.5,0.879222108495394,-0.18570043082992188,2.6118847429009227E-3,2.5830459914959443,0.031278521583696935,1.504753782569229,652]
["High","Q9UGU0","Transcription factor 20 [OS=Homo sapiens]",7,12,14,12,1960,211.6,9.04,29.68,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","TCF20","ENSG00000100207; ENSG00000262024; ENSG00000276461; ENSG00000280467; ENSG00000281897; ENSG00000282892; ENSG00000283026; ENSG00000283681","Matrix metalloproteinases","","",826.1,803.5,846.6,933.9,802.7,833.8,{"$f":"AVERAGE(T7170:V7170)/AVERAGE(W7170:Y7170)","v":0.9633520074696547},{"$f":"LOG(Z7170,2)","v":-0.05386504174322106},{"$f":"TTEST(T7170:V7170,W7170:Y7170,2,2)","v":0.4913189079103222},{"$f":"-LOG10(AB7170)","v":0.3086365221605016},{"$f":"AB7170*7808/AF7170","v":0.6630172887942958},{"$f":"-LOG10(AD7170)","v":0.17847514681383028},5786]
["High","Q9UGY1","Nucleolar protein 12 [OS=Homo sapiens]",21,3,5,2,213,24.6,10.23,11.14,"","nucleus","nucleic acid binding activity;other molecular function","NOL12","ENSG00000273899","","Major pathway of rRNA processing in the nucleolus and cytosol","",70.2,57.1,81.1,88.3,66.4,73.3,0.9140350877192983,-0.1296785467735957,0.5287275551644106,0.2767680553145623,0.6912767499537371,0.16034804970891467,5972]
["High","Q9UHB7-1","AF4/FMR2 family member 4 [OS=Homo sapiens]",12,10,14,10,1163,127.4,9.31,27.56,"other biological processes","nucleus;other cell component","","AFF4","ENSG00000072364","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",348.6,296.6,358.4,391.7,341,365.7,0.9136926438455936,-0.13021915473792808,0.2604013261172331,0.5843568084144055,0.44393309046361484,0.35268248175963934,4580]
["High","Q9UHD2","Serine/threonine-protein kinase TBK1 [OS=Homo sapiens]",24,14,25,14,729,83.6,6.79,68.53,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;kinase activity;other molecular function","TBK1","ENSG00000183735","TNF-alpha signaling pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Toll-like receptor signaling pathway","Negative regulators of DDX58/IFIH1 signaling; Potential therapeutics for SARS; Interleukin-37 signaling; IRF3-mediated induction of type I IFN; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; TICAM1-dependent activation of IRF3/IRF7; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Regulation of innate immune responses to cytosolic DNA; STAT6-mediated induction of chemokines; IRF3 mediated activation of type 1 IFN","Ras signaling pathway; Mitophagy; Autophagy; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; IL-17 signaling pathway; Alcoholic liver disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Shigellosis; Yersinia infection; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis",1179.2,1155.9,1116.7,1145.1,1165.1,1113.1,1.0083253001489794,0.011961147965518377,0.7090688392939348,0.1493115996911101,0.8239930789116005,0.08407643612220964,6719]
["High","Q9UHI8","a disintegrin and metalloproteinase with thrombospondin motifs 1 [OS=Homo sapiens]",9,6,8,6,967,105.3,6.83,17.04,"cell organization and biogenesis;protein metabolism;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","other molecular function","ADAMTS1","ENSG00000154734","VEGFA-VEGFR2 signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Malignant pleural mesothelioma","Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins; Degradation of the extracellular matrix","",312.8,335.6,320.8,208.8,225.6,223.5,1.4731722146222832,0.5589260920565969,2.6046653354034184E-4,3.5842480698018835,0.012953647731738783,1.887607917552482,157]
["High","Q9UHL0-1","ATP-dependent RNA helicase DDX25 [OS=Homo sapiens]",8,2,10,1,483,54.7,6.28,20.64,"other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX25","ENSG00000109832","","","",15.3,12.6,16.4,21.5,27.2,24,0.6093535075653369,-0.7146486653645763,0.009064115420528545,2.042674572895377,0.057773561798764805,1.2382708569372929,1225]
["High","Q9UHQ4","B-cell receptor-associated protein 29 [OS=Homo sapiens]",27,8,13,8,241,28.3,9.54,25.33,"transport;other biological processes","other membranes;ER/Golgi","","BCAP29","ENSG00000075790; ENSG00000283852","","","",882.4,895.8,916.8,875.3,877.5,891.1,1.0193275086047127,0.02761766202945325,0.2017660645580657,0.6951518768231343,0.37733878612440164,0.4232685519841198,4175]
["High","Q9UHV7","mediator of RNA polymerase II transcription subunit 13 [OS=Homo sapiens]",0,1,1,1,2174,239.1,5.64,2.62,"other biological processes","nucleus","other molecular function","MED13","ENSG00000108510","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",52.6,54,75.5,70,59.8,53.1,0.9956260251503553,-0.006324152771878398,0.9775116278883781,0.009878067796317348,0.9882702046552448,0.0051242979760535,7723]
["High","Q9UI10-1","translation initiation factor eIF-2B subunit delta [OS=Homo sapiens]",34,13,32,1,523,57.5,9.38,82.69,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF2B4","ENSG00000115211","Translation factors","Recycling of eIF2:GDP","Herpes simplex virus 1 infection",16.6,14.4,16.3,16,15.7,18.6,0.9403578528827038,-0.08871821646613187,0.43356164003027514,0.3629491495788554,0.6149408329439398,0.21116666822799054,5505]
["High","Q9UI95","Mitotic spindle assembly checkpoint protein MAD2B [OS=Homo sapiens]",16,3,5,3,211,24.3,6.52,2.43,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD2L2","ENSG00000116670","Cell cycle","Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Bacterial invasion of epithelial cells",162.5,170.7,135.6,143.7,195.3,154.1,0.9507199351044412,-0.0729076830788713,0.6916649920290687,0.16010420517046428,0.8112543574827954,0.09084295746349963,6657]
["High","Q9UIF8-1","Bromodomain adjacent to zinc finger domain protein 2B [OS=Homo sapiens]",1,2,2,2,2168,240.3,6.54,6.12,"cell organization and biogenesis;other biological processes","nucleus","nucleic acid binding activity;other molecular function","BAZ2B","ENSG00000123636","","","",78.8,77.1,73.9,80.9,84.4,87.4,0.9093787099327265,-0.1370468662986619,0.03202911491652006,1.494455062340934,0.11653463619207298,0.933544975312231,2146]
["High","Q9UIJ7-1","GTP:AMP phosphotransferase AK3, mitochondrial [OS=Homo sapiens]",65,13,42,13,227,25.6,9.16,65.5,"other metabolic processes;stress response","mitochondrion;other cell component","kinase activity;other molecular function","AK3","ENSG00000147853; ENSGGOG00000028122","","Factors involved in megakaryocyte development and platelet production","Purine metabolism; Biosynthesis of cofactors",1971.1,2002.8,2065.4,1848.2,1934.9,1893.2,1.0639501083452247,0.0894305003404777,0.031659109006466866,1.499501311805308,0.11561942147918303,0.9369692080194318,2138]
["High","Q9UIW2","Plexin-A1 [OS=Homo sapiens]",10,16,21,13,1896,210.9,6.92,39.52,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","PLXNA1","ENSG00000114554","","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Sema3A PAK dependent Axon repulsion; RHOD GTPase cycle; RND1 GTPase cycle; CRMPs in Sema3A signaling; Other semaphorin interactions","Axon guidance",651.5,644.7,656.8,709.3,633.2,713.2,0.950041348445785,-0.07393778997059051,0.26256264022230913,0.5807670691816935,0.4467398332655894,0.3499453222177174,4589]
["Medium","Q9UJ99","Cadherin-22 [OS=Homo sapiens]",2,1,4,1,828,89,4.81,0,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CDH22","ENSG00000149654","Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Malignant pleural mesothelioma","","",35.2,28.6,28.5,34.4,34.2,25.6,0.9798301486199578,-0.029396411967008637,0.870698183791289,0.060132361444066494,0.9254575849499571,0.03364348079470605,7346]
["High","Q9UJQ4","Sal-like protein 4 [OS=Homo sapiens]",19,14,33,13,1053,112.2,7.47,77.44,"cell cycle OR cell proliferation;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SALL4","ENSG00000101115","Vitamin D receptor pathway; Wnt/beta-catenin signaling pathway in leukemia","Regulation of PTEN gene transcription; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","",935.4,896.8,914.1,2486.9,2293.8,2439.5,0.38036342483587704,-1.3945495693639813,1.470835161130642E-5,4.832435996628514,0.004993165625264371,2.301624027987472,23]
["High","Q9UJU6-2","Isoform 2 of Drebrin-like protein [OS=Homo sapiens]",47,15,51,1,431,48.3,5.05,132.53,"","","","DBNL","","","","",124.9,117.1,108.9,96.5,94.1,123.9,1.115739268680445,0.15799993063551496,0.3168334788813037,0.4991689340105755,0.5038362124450548,0.29771062147490857,4910]
["High","Q9UJX4","Anaphase-promoting complex subunit 5 [OS=Homo sapiens]",21,11,18,11,755,85,6.87,38.35,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ANAPC5","ENSG00000089053","Cell cycle","Separation of Sister Chromatids; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of APC/C activators between G1/S and early anaphase; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; IL-17 signaling pathway; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection",378.2,385.5,370.3,335.2,353.3,360.2,1.0813388004195672,0.11281861290147037,0.03030355170798613,1.5185064673134352,0.11240386305746114,0.9492187628264868,2105]
["High","Q9UJZ1","Stomatin-like protein 2, mitochondrial [OS=Homo sapiens]",67,18,146,18,356,38.5,7.39,292.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","signal transduction activity or receptor binding;other molecular function","STOML2","ENSG00000165283","","Processing of SMDT1","",3096.6,3159.9,3193.8,3096.2,3146.5,3094,1.0121670397463771,0.01744740023710702,0.31828875710004095,0.49717870167320993,0.5052243576818702,0.2965157195739059,4919]
["High","Q9UK58","Cyclin-L1 [OS=Homo sapiens]",9,3,4,3,526,59.6,10.7,9.86,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","enzyme regulator activity","CCNL1","ENSG00000163660","","","",185.6,156.4,153.6,203.9,185.9,182.8,0.8655256723716382,-0.20835148285875124,0.10248304075993088,0.9893479971815284,0.2441084753671569,0.6124171417573734,3278]
["High","Q9UKA9-1","Polypyrimidine tract-binding protein 2 [OS=Homo sapiens]",27,8,38,1,531,57.5,8.66,69.19,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","LOC101350812; PTBP2","ENSANAG00000033752; ENSCSAG00000001494; ENSG00000117569; ENSMMUG00000016130; ENSPANG00000001229; ENSPPYG00000001132","Genes targeted by miRNAs in adipocytes; mRNA processing","","",414.5,436.6,412.4,570.5,622.8,588.8,0.7089950058919253,-0.4961526296233165,5.4707400159733754E-4,3.2619539235539117,0.016685757048718795,1.777654084207126,256]
["High","Q9UKF6","Cleavage and polyadenylation specificity factor subunit 3 [OS=Homo sapiens]",21,11,23,11,684,77.4,5.6,59.14,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","CPSF3","ENSG00000119203","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript","mRNA surveillance pathway",666.2,665.2,586.3,503.5,569.5,556.7,1.1767196416518377,0.2347706332240551,0.04488369343647072,1.3479114126012877,0.1439818727822364,0.8416921818366985,2434]
["High","Q9UKK3","Poly [ADP-ribose] polymerase 4 [OS=Homo sapiens]",3,3,3,3,1724,192.5,5.66,3.75,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP4","ENSG00000102699","NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome","Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein","Base excision repair; Apoptosis",50.5,52.5,54.6,44.9,54.9,42.5,1.1075193253689388,0.14733187292989383,0.2690149776151648,0.5702235396461502,0.45327340207578914,0.34363976444147165,4634]
["High","Q9UKM9-2","Isoform 1 of RNA-binding protein Raly [OS=Homo sapiens]",55,14,62,14,290,30.3,9.63,140.27,"","","","RALY","","","","",3055.2,3217,3158.1,2984.4,3262.8,3063.6,1.0128345577179187,0.018398535192589993,0.697614868398224,0.15638427177604758,0.8165157985989107,0.08803540776999538,6671]
["High","Q9UKU7","Isobutyryl-CoA dehydrogenase, mitochondrial [OS=Homo sapiens]",9,4,5,4,415,45,7.85,8.28,"other metabolic processes","mitochondrion","other molecular function","ACAD8","ENSG00000151498","","Branched-chain amino acid catabolism","Valine, leucine and isoleucine degradation; Metabolic pathways",276.2,319.8,289.9,270.5,325.3,310.2,0.9778145695364239,-0.032367193078486976,0.763530449180412,0.11717363883369399,0.861758564209404,0.06461439185340126,6918]
["High","Q9UKW4","Guanine nucleotide exchange factor VAV3 [OS=Homo sapiens]",4,4,6,3,847,97.7,7.05,14.63,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;cytosol","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","VAV3","ENSG00000134215","Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mesodermal commitment pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; T-cell receptor (TCR) signaling pathway","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOG GTPase cycle; RAC2 GTPase cycle; FCERI mediated Ca+2 mobilization; FCERI mediated MAPK activation; DAP12 signaling; EPH-ephrin mediated repulsion of cells; GPVI-mediated activation cascade; VEGFR2 mediated vascular permeability","Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Yersinia infection; Proteoglycans in cancer; Lipid and atherosclerosis",136.8,152.1,138,173.4,154,155.4,0.8842170671085335,-0.1775275135073829,0.07896012043724758,1.102592197911974,0.20647040200067954,0.6851421966423452,2986]
["High","Q9UL15-1","BAG family molecular chaperone regulator 5 [OS=Homo sapiens]",27,9,18,9,447,51.2,6.05,33.98,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","BAG5","ENSG00000166170","","Regulation of HSF1-mediated heat shock response","",492,470.9,512.7,468.1,467.7,497.3,1.029655990510083,0.04216241150239706,0.41368613542760524,0.3833290341158126,0.5952932814999524,0.22526901888275447,5426]
["High","Q9UL63-1","muskelin [OS=Homo sapiens]",21,11,18,11,735,84.7,6.34,26.5,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","MKLN1","ENSG00000128585","Ciliary landscape","","",604.1,686.8,594.8,647.2,669.9,593.8,0.9868124967292901,-0.019152109229852676,0.8312177018315625,0.08028521650248414,0.9039203086212869,0.04386985608614909,7180]
["High","Q9ULD9","zinc finger protein 608 [OS=Homo sapiens]",2,3,6,2,1512,162.1,8.79,11.89,"other biological processes","nucleus","other molecular function","ZNF608","ENSG00000168916","","","",185.7,134.4,178.2,231.7,146.9,186.2,0.8822592067988669,-0.18072551458764782,0.49090286516759374,0.30900443312147013,0.6629141423778229,0.1785427157974738,5782]
["High","Q9ULH1-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",3,3,5,3,1129,125.4,7.31,9.77,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ASAP1","ENSG00000153317","EGF/EGFR signaling pathway; CCL18 signaling pathway","VxPx cargo-targeting to cilium","Endocytosis; Fc gamma R-mediated phagocytosis",78.4,74.6,71.6,60.1,55.7,54.6,1.3180751173708918,0.3984325921747627,0.002212599718797621,2.655097147139681,0.029632896405440517,1.5282258972400597,583]
["High","Q9ULJ7-1","Ankyrin repeat domain-containing protein 50 [OS=Homo sapiens]",5,5,7,5,1429,155.8,6.6,20.17,"transport","other cytoplasmic organelle","","ANKRD50","ENSG00000151458","","","",271.6,264.4,262.8,250,249.1,231.2,1.0937970696973847,0.1293451022092738,0.026998327646134416,1.5686631364539578,0.10513862456908604,0.9782377087515235,2005]
["High","Q9ULT8","E3 ubiquitin-protein ligase hectd1 [OS=Homo sapiens]",16,39,61,39,2610,289.2,5.35,119.59,"protein metabolism;other metabolic processes;developmental processes;other biological processes","","other molecular function","HECTD1","ENSG00000092148","","Antigen processing: Ubiquitination & Proteasome degradation","",2603.7,2710.5,2616.2,3027.1,3051.4,3065.9,0.8672411530554219,-0.20549487659469712,3.400731311904928E-4,3.4684276798481326,0.013975215833344042,1.8546414761423262,190]
["High","Q9ULV0","unconventional myosin-Vb [OS=Homo sapiens]",3,6,6,2,1848,213.5,7.2,9.72,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5B","ENSG00000167306","","Vasopressin regulates renal water homeostasis via Aquaporins","Pathogenic Escherichia coli infection",84,80.7,83.9,82.1,83.1,77.7,1.0234664470975712,0.033463806416620175,0.39188139742947264,0.40684535194797733,0.575585017142461,0.23989051956003626,5316]
["High","Q9ULZ3","apoptosis-associated speck-like protein containing a CARD [OS=Homo sapiens]",50,10,31,10,195,21.6,6.34,70.96,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PYCARD","ENSG00000103490","Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling","Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; CLEC7A/inflammasome pathway","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Lipid and atherosclerosis",1278.3,1312.7,1336.1,1406.9,1586.6,1556.9,0.8630230309423348,-0.2125290346917756,0.023241061061857266,1.6337440482786827,0.09631964159818553,1.016285142076906,1884]
["High","Q9UM47","Neurogenic locus notch homolog protein 3 [OS=Homo sapiens]",4,8,13,6,2321,243.5,5.39,17.82,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","NOTCH3","ENSG00000074181","Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; OSX and miRNAs in tooth development; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Neovascularisation processes; Osteoblast differentiation and related diseases; Notch signaling pathway","Pre-NOTCH Transcription and Translation; Pre-NOTCH Processing in Golgi; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Pre-NOTCH Processing in the Endoplasmic Reticulum; Defective LFNG causes SCDO3; Noncanonical activation of NOTCH3","Endocrine resistance; Notch signaling pathway; Apelin signaling pathway; Th1 and Th2 cell differentiation; Thyroid hormone signaling pathway; Human papillomavirus infection; Pathways in cancer; MicroRNAs in cancer; Breast cancer",295.5,295.4,300.6,352.3,331.8,343.6,0.8674710518633844,-0.20511248017048908,1.83220984192363E-3,2.7370247883261434,0.028105882997523975,1.5512027660042669,509]
["Medium","Q9UN36-1","Protein NDRG2 [OS=Homo sapiens]",4,2,2,1,371,40.8,5.21,3.96,"cell-cell signaling;signal transduction;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","NDRG2","ENSG00000165795","","","",52.4,46.8,62,69,65.9,64.5,0.8084252758274824,-0.30681366587022874,0.05146195976495015,1.2885136790876335,0.15616594708306678,0.8064136606393447,2573]
["Low","Q9UNA0","A disintegrin and metalloproteinase with thrombospondin motifs 5 [OS=Homo sapiens]",1,1,1,1,930,101.7,8.85,0,"cell organization and biogenesis;protein metabolism;stress response;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi","signal transduction activity or receptor binding;other molecular function","ADAMTS5","ENSG00000154736","Vitamin D receptor pathway; Endochondral ossification; IL-18 signaling pathway; Endochondral ossification with skeletal dysplasias","Degradation of the extracellular matrix; Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins","",360.2,429.8,385.5,263,408,316.8,1.1900182223122089,0.25098366516193943,0.25353167363008555,0.5959677766719245,0.4366068168733366,0.3599094878037876,4534]
["High","Q9UNE7-1","E3 ubiquitin-protein ligase CHIP [OS=Homo sapiens]",29,8,13,8,303,34.8,5.87,33.16,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","STUB1","ENSCATG00000030791; ENSCSAG00000012299; ENSG00000103266; ENSGGOG00000043504; ENSMFAG00000031388; ENSMNEG00000033024; ENSPPAG00000028029; ENSPPYG00000006921; ENSPTRG00000007553; ENSRBIG00000029383; ENSRROG00000037882","Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway; Androgen receptor signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Downregulation of TGF-beta receptor signaling","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",571,486,576,513.9,456.7,471,1.1327691453940067,0.17985387463551883,0.13283955465288175,0.8766725890516726,0.28940045835092093,0.5385007853831247,3584]
["High","Q9UNL2","Translocon-associated protein subunit gamma [OS=Homo sapiens]",15,4,14,4,185,21.1,9.61,35.32,"transport","other membranes;ER/Golgi","","SSR3","ENSG00000114850","VEGFA-VEGFR2 signaling pathway","SRP-dependent cotranslational protein targeting to membrane","Protein processing in endoplasmic reticulum",575.4,597,580.6,554.9,559.8,517.4,1.0740763433613139,0.10309654106485167,0.05372620577457485,1.269813828877599,0.1596856546204341,0.796734097005034,2627]
["High","Q9UNN8","Endothelial protein C receptor [OS=Homo sapiens]",5,1,3,1,238,26.7,7.18,4.91,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","PROCR","ENSG00000101000","","Cell surface interactions at the vascular wall; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",18.4,22.3,20.7,37.7,41.4,38.3,0.5229982964224873,-0.9351218477398726,3.1701503467386504E-4,3.4989201405549246,0.013452464080073579,1.8711981589058255,184]
["High","Q9UNY4-1","transcription termination factor 2 [OS=Homo sapiens]",27,25,46,25,1162,129.5,8.37,93.56,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","TTF2","ENSG00000116830","Thyroid stimulating hormone (TSH) signaling pathway; Thyroid hormones production and peripheral downstream signaling effects","","Thyroid hormone synthesis",1581.6,1598.2,1623.9,1700.7,1670.2,1683.4,0.950418455572483,-0.07336524369777678,5.275048198338142E-3,2.2777735678451205,0.0442401464367607,1.3541834441678278,931]
["High","Q9UPN9-1","E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",34,27,62,2,1127,122.5,6.67,131.34,"protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TRIM33","ENSG00000197323","Ectoderm differentiation","Downregulation of SMAD2/3:SMAD4 transcriptional activity","",2577.4,2573.2,2595.8,2825.6,2766.3,2800.2,0.9230585908175548,-0.11550586955243732,3.1368010043405446E-4,3.503513031655476,0.013383684285186322,1.8734243167272697,183]
["High","Q9UPN9-2","Isoform Beta of E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",33,26,63,1,1110,120.5,6.67,137.02,"","","","TRIM33","","","","",178.7,155.2,164.9,179.3,181.5,154.5,0.967979817581991,-0.04695112732335891,0.6438953140542207,0.19118473547286965,0.7771733826148332,0.10948208195472256,6469]
["High","Q9UPT8","Zinc finger CCCH domain-containing protein 4 [OS=Homo sapiens]",18,15,42,14,1303,140.2,6.27,67.32,"other biological processes","cytosol;nucleus","other molecular function","ZC3H4","ENSG00000130749","","","",1066.7,1019,1018.4,1307.1,1024,1127.4,0.8975278299840973,-0.15597142106859496,0.23345776586276498,0.6317916748912381,0.41390513984025185,0.38309918053231684,4404]
["High","Q9UPX8","SH3 and multiple ankyrin repeat domains protein 2 [OS=Homo sapiens]",5,7,7,7,1470,158.7,6.9,10.03,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","SHANK2","ENSG00000162105","","Neurexins and neuroligins","Glutamatergic synapse",328.8,298.6,317.9,375.1,311.3,312.2,0.9466252753855396,-0.079134651591397,0.48097982250392485,0.3178731422519655,0.6551797721756185,0.18363951931863692,5732]
["High","Q9UPY8","Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",10,3,7,1,281,32,5.54,11.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAPRE3","ENSG00000084764","","","",107,123.5,118.7,118.7,134.9,131.4,0.9070129870129868,-0.14080488684018633,0.16087045064748787,0.7935237215895232,0.32599960515327936,0.48678292594388867,3853]
["High","Q9UQB3-1","Catenin delta-2 [OS=Homo sapiens]",3,3,3,3,1225,132.6,7.74,2.46,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","CTNND2","ENSG00000169862; ENSPTRG00000016731","Ectoderm differentiation; Ectoderm differentiation","","Wnt signaling pathway",73.7,73.1,59.2,44.2,48.1,48.6,1.4620298083747338,0.5479727257609441,0.011729116947971184,1.9307346834564636,0.06598050801855836,1.1805843449166642,1388]
["High","Q9Y217-1","Myotubularin-related protein 6 [OS=Homo sapiens]",8,4,6,4,621,71.9,7.66,13.34,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","MTMR6","ENSG00000139505; ENSPPAG00000035079","","Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",200.2,196.3,206.5,231.8,215.4,233.3,0.8861131520940485,-0.17443715960390987,0.01612218303901424,1.792576152505691,0.07848005309764539,1.1052407117952003,1604]
["High","Q9Y230","RuvB-like 2 [OS=Homo sapiens]",62,26,112,26,463,51.1,5.64,212.05,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","RUVBL2","ENSG00000183207","","HATs acetylate histones; Telomere Extension By Telomerase","",5160.3,5229.1,4981.1,4957.2,5298.5,4988.3,1.0082983468905802,0.011922583177003966,0.7647995096817308,0.11645239916107106,0.862692079109355,0.0641441894605445,6922]
["High","Q9Y250","Leucine zipper putative tumor suppressor 1 [OS=Homo sapiens]",17,8,9,8,596,66.6,7.09,14.92,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;other cell component","cytoskeletal activity","LZTS1","ENSG00000061337","","","",320.3,328.8,319.9,454.7,340.2,348.4,0.8475465757019156,-0.23863544323088076,0.19134634536447867,0.7181798282040364,0.36466494132434696,0.4381059874985433,4097]
["High","Q9Y277","Voltage-dependent anion-selective channel protein 3 [OS=Homo sapiens]",51,12,51,10,283,30.6,8.66,130.66,"transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","VDAC3","ENSG00000078668","Alzheimer's disease and miRNA effects; Ferroptosis; Hepatitis B infection; Alzheimer's disease","Ub-specific processing proteases; Mitochondrial calcium ion transport","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Hepatitis B; Human T-cell leukemia virus 1 infection; Viral carcinogenesis; Chemical carcinogenesis; Diabetic cardiomyopathy",1804,2224.1,1856.8,1689.9,2199.8,2002.9,0.9986932763126632,-1.8864365778172628E-3,0.990314050212931,0.004227059295316044,0.9951572849501371,2.1082734375948817E-3,7770]
["High","Q9Y282-1","Endoplasmic reticulum-Golgi intermediate compartment protein 3 [OS=Homo sapiens]",24,10,20,10,383,43.2,6.06,39.07,"transport","other membranes;ER/Golgi;other cell component","","ERGIC3","ENSCANG00000036642; ENSCATG00000041920; ENSG00000125991; ENSGGOG00000027615; ENSMFAG00000037850; ENSMLEG00000032774; ENSMNEG00000030061; ENSPANG00000011730; ENSPPAG00000037078; ENSPTRG00000013442; ENSRROG00000033106","","","",618.9,668.3,683.5,732.2,745.9,739.5,0.88866341991342,-0.17029099120578314,0.014421391326334297,1.8409928383543972,0.07321340928219648,1.1354093691611742,1538]
["High","Q9Y2B1","UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase [OS=Homo sapiens]",5,2,2,2,443,51.1,8.32,4.19,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus","other molecular function","RXYLT1","ENSG00000118600","","","Mannose type O-glycan biosynthesis; Metabolic pathways",165.2,157.4,142.8,131.7,123.3,139.8,1.178824721377913,0.23734922094895114,0.04405511564362111,1.3560036544074316,0.14225903347617602,0.8469201462735493,2418]
["High","Q9Y2F5","Little elongation complex subunit 1 [OS=Homo sapiens]",4,7,7,7,2266,247.7,5.48,11.53,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","ICE1","ENSG00000164151","","RNA polymerase II transcribes snRNA genes","",227.7,198.6,206.1,175.2,191.7,180.7,1.1548575602629658,0.20771492110047146,0.047245079387593994,1.3256434169133744,0.14868584436047316,0.827730376526948,2481]
["High","Q9Y2G8","DnaJ homolog subfamily C member 16 [OS=Homo sapiens]",16,8,14,8,782,90.5,7.12,37.2,"","other membranes","","DNAJC16","ENSG00000116138","","","",493.7,477.4,467.3,470.6,453.3,486.1,1.0201418439716312,0.028769763340929087,0.4811691818531495,0.31770219633578317,0.6549806436383179,0.1837715343368915,5736]
["Medium","Q9Y2I8","WD repeat-containing protein 37 [OS=Homo sapiens]",1,1,1,1,494,54.6,7.23,2.3,"","nucleus;other cell component","","WDR37","ENSG00000047056","","","",89.3,99.3,84.3,123.8,92.6,99.7,0.8633343878519455,-0.2120086406303581,0.23917556716824126,0.6212831875012436,0.42098350506078175,0.37573492031973066,4436]
["High","Q9Y2J4","Angiomotin-like protein 2 [OS=Homo sapiens]",6,4,4,4,779,85.7,7.3,6.13,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","AMOTL2","ENSG00000114019","","Signaling by Hippo","Tight junction",189.1,174.6,196.6,164.7,135.5,160.4,1.216456795484151,0.28268508143734455,0.04081888363116852,1.3891388771175757,0.13597006970655454,0.8665566798049932,2344]
["High","Q9Y2R0","Cytochrome c oxidase assembly factor 3 homolog, mitochondrial [OS=Homo sapiens]",26,3,6,3,106,11.7,9.6,12.73,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion","","COA3","ENSG00000183978","Mitochondrial complex IV assembly","","Thermogenesis",263.7,220.5,303.7,201.8,219.1,201.9,1.265093127809891,0.3392435905197528,0.08982342493380001,1.0466103894704506,0.22399913825714163,0.6497536524287305,3131]
["High","Q9Y2R9","28S ribosomal protein S7, mitochondrial [OS=Homo sapiens]",17,3,5,3,242,28.1,9.99,8.48,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS7","ENSG00000125445","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",287.4,252.1,308.5,291,239.7,233.2,1.1100929441026313,0.1506804733162389,0.31796129609706864,0.49762574138180177,0.504909863722984,0.29678614501332784,4917]
["High","Q9Y2V7-1","Conserved oligomeric Golgi complex subunit 6 [OS=Homo sapiens]",10,7,11,7,657,73.2,5.76,22.47,"other metabolic processes;transport","other membranes;ER/Golgi","","COG6","ENSG00000133103","","COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",500.9,539.1,500.7,453.7,555.3,503.2,1.0188467133976988,0.02693701278345623,0.7812770302834449,0.10719494385603497,0.8719569829121122,0.059504940004038505,6996]
["High","Q9Y2Y0","ADP-ribosylation factor-like protein 2-binding protein [OS=Homo sapiens]",34,5,13,5,163,18.8,4.35,32,"signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","ARL2BP","ENSG00000102931","Ciliopathies","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane","",443.6,466.6,440.1,415.8,399.3,366.9,1.1423857868020306,0.19204993504181303,0.027768424467178796,1.5564487606754316,0.1067007176376634,0.9718326596286779,2032]
["Low","Q9Y2Z2","Protein MTO1 homolog, mitochondrial [OS=Homo sapiens]",1,1,1,1,717,79.9,8.31,0,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","MTO1","ENSG00000135297","","tRNA modification in the mitochondrion","",13.7,10.7,10.4,18.4,15.4,18.1,0.6705202312138728,-0.5766472325091525,0.015989874506204725,1.7961549447263527,0.07807938720728361,1.107463603813952,1599]
["High","Q9Y2Z4","Tyrosine--tRNA ligase, mitochondrial [OS=Homo sapiens]",45,17,69,17,477,53.2,8.98,146.02,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","YARS2","ENSG00000139131","Orexin receptor pathway","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",2270.9,2388.9,2351,2482.8,2645.9,2555.6,0.9123537602644352,-0.13233476477353556,0.018611450520878748,1.7302197779350819,0.08538084939307947,1.0686395290250157,1702]
["Medium","Q9Y2Z9-1","Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [OS=Homo sapiens]",2,1,1,1,468,50.8,7.3,0,"other metabolic processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","COQ6","ENSG00000119723","Nephrotic syndrome","Ubiquinol biosynthesis","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",33,49.2,38.8,41.1,45.2,42.8,0.9372579395817195,-0.09348195314523389,0.6099576954168943,0.21470028512713352,0.7527342636028307,0.12335831492764701,6327]
["High","Q9Y303","N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",16,5,6,5,409,43.7,6.7,13.48,"other metabolic processes","cytosol","other molecular function","AMDHD2","ENSG00000162066","","Synthesis of UDP-N-acetyl-glucosamine","Amino sugar and nucleotide sugar metabolism; Metabolic pathways",188.6,178.4,178.6,208.8,215.4,176.8,0.907820299500832,-0.13952134657437526,0.21025219485292662,0.6772594618437756,0.38782167196117434,0.4113679256591505,4233]
["High","Q9Y305-1","Acyl-coenzyme A thioesterase 9, mitochondrial [OS=Homo sapiens]",31,12,33,12,439,49.9,8.6,73.44,"other metabolic processes","mitochondrion","other molecular function","ACOT9","ENSG00000123130","VEGFA-VEGFR2 signaling pathway","Mitochondrial Fatty Acid Beta-Oxidation","",1134.7,1209.4,1155.6,1140.4,1213.4,1196.2,0.9858309859154931,-0.02058776743464764,0.6207277636890356,0.207098829212175,0.7612128755903864,0.11849387441738136,6367]
["High","Q9Y312","Protein AAR2 homolog [OS=Homo sapiens]",29,8,27,8,384,43.4,5.96,31.97,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","","AAR2","ENSG00000131043","Ciliary landscape","","",452.5,443.9,479.6,418.8,379.8,402.4,1.1457119067443797,0.19624431899646388,0.020156192881160558,1.6955914943913386,0.0883658360562053,1.0537156091959468,1781]
["High","Q9Y314","nitric oxide synthase-interacting protein [OS=Homo sapiens]",47,9,14,9,301,33.2,8.82,34.49,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","NOSIP","ENSG00000142546","","NOSIP mediated eNOS trafficking","",550.2,537.7,549.5,493.9,478.2,470.3,1.135191347753744,0.18293549856295555,1.268407368738185E-3,2.8967412436293096,0.02374993941272841,1.624337493944432,417]
["High","Q9Y315","deoxyribose-phosphate aldolase [OS=Homo sapiens]",31,9,19,9,318,35.2,8.94,32.66,"other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","DERA","ENSG00000023697","Pentose phosphate pathway in senescent cells","Neutrophil degranulation; Pentose phosphate pathway","Pentose phosphate pathway; Metabolic pathways",671.5,700.3,695.9,704.3,767.4,756.5,0.9279687640247734,-0.10785185068213182,0.06704938001827264,1.1736052335601515,0.1850553408210225,0.7326983763585069,2829]
["High","Q9Y316-1","Protein MEMO1 [OS=Homo sapiens]",21,5,11,5,297,33.7,7.14,22.28,"other biological processes","","other molecular function","LOC111154137; LOC114499315; MEMO1","ENSANAG00000021250; ENSCANG00000020056; ENSCATG00000030724; ENSCCAG00000037443; ENSCHIG00000006439; ENSCJAG00000003208; ENSDLEG00000015222; ENSECAG00000019946; ENSFCAG00000001385; ENSG00000162959; ENSHGLG00000018935; ENSMMUG00000003908; ENSMNEG00000040106; ENSMODG00000047380; ENSPANG00000022798; ENSPCOG00000018130; ENSPCTG00005009736; ENSPTRG00000050445; ENSRFEG00010015180; ENSSSCG00000008515; ENSSSCG00070008027; ENSVURG00010020209; ENSVVUG00000007616","","ERBB2 Regulates Cell Motility; ERBB2 Regulates Cell Motility","",535,535.1,510.4,587.9,533.6,570,0.9343777712089861,-0.09792214188948974,0.1085018030295736,0.9645630448634853,0.25372329381698433,0.5956396592592207,3339]
["High","Q9Y320","Thioredoxin-related transmembrane protein 2 [OS=Homo sapiens]",29,7,29,7,296,34,8.69,56.44,"developmental processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","TMX2","ENSG00000213593","","","",1304.6,1362.1,1342.3,1353.1,1503.5,1405.1,0.9407044137316094,-0.08818662149172489,0.14898051124219155,0.8268705397323401,0.3094545974405511,0.5094030607875172,3759]
["High","Q9Y324","rRNA-processing protein FCF1 homolog [OS=Homo sapiens]",10,2,3,2,198,23.4,9.7,7.51,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","FCF1","ENSG00000119616","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",140.7,122.2,135.4,112.3,112.1,111.1,1.1871833084947838,0.24754271327664007,0.01915066063686361,1.717816239659035,0.08653261472953187,1.062820173143274,1728]
["High","Q9Y333","U6 snRNA-associated Sm-like protein LSm2 [OS=Homo sapiens]",67,5,22,5,95,10.8,6.52,32.21,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM2","ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",627.7,830.5,692.9,605.4,915.7,753.1,0.9458710755430482,-0.08028454065688498,0.7226180185185167,0.14109121347710205,0.8336586123807,0.07901175884943379,6768]
["High","Q9Y365","START domain-containing protein 10 [OS=Homo sapiens]",4,1,1,1,291,33,7.12,3.13,"transport","other membranes;cytosol;cytoskeleton;other cell component","other molecular function","STARD10","ENSG00000214530","","Synthesis of PC","",18.1,11.2,11.7,15.4,14.9,14.1,0.9234234234234234,-0.11493576684465993,0.6414332468413123,0.1928485334229879,0.77576065541155,0.11027225047836646,6456]
["High","Q9Y366","Intraflagellar transport protein 52 homolog [OS=Homo sapiens]",9,2,4,2,437,49.7,5.26,10.33,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","IFT52","ENSG00000101052","Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",32,30.4,30.3,38.8,39.6,38.4,0.7936643835616438,-0.33339903025448653,2.5237843834847871E-4,3.5979477512752513,0.012713360300805946,1.8957396447869075,155]
["High","Q9Y371","Endophilin-B1 [OS=Homo sapiens]",36,11,39,10,365,40.8,6.04,80.37,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GLB1","ENSG00000097033","Nanoparticle triggered autophagic cell death","","Autophagy; Endocytosis",1852.9,1872,1844.6,2033.9,1987.2,2004.3,0.9243369734789391,-0.11350920283311973,6.6469674645121485E-4,3.1773764469995047,0.01827447956440523,1.738154982387907,284]
["High","Q9Y375","Complex I intermediate-associated protein 30, mitochondrial [OS=Homo sapiens]",33,9,17,9,327,37.7,7.64,48.38,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion","other molecular function","NDUFAF1","ENSG00000137806","Mitochondrial immune response to SARS-CoV-2","Complex I biogenesis","Thermogenesis",685.9,720,726,641,628.4,629.4,1.1227617442595321,0.16705181300715,4.078965406044765E-3,2.3894499779453655,0.03874520911240575,1.4117819908267806,822]
["High","Q9Y376","Calcium-binding protein 39 [OS=Homo sapiens]",36,13,28,12,341,39.8,6.89,47.44,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CAB39","ENSG00000135932","AMP-activated protein kinase (AMPK) signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias","Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK","mTOR signaling pathway; AMPK signaling pathway",1642.6,1689.7,1666.6,1482.3,1566.7,1514.2,1.0954812412342216,0.1315647801655867,6.669345329799666E-3,2.1759167948105245,0.04954733428646602,1.3049797061801311,1051]
["High","Q9Y383","Putative RNA-binding protein Luc7-like 2 [OS=Homo sapiens]",41,19,111,13,392,46.5,10.01,244.56,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","LUC7L2","ENSG00000146963","","","",5144.7,4750,4995.7,5251.5,4803.1,5112.2,0.9817759843869507,-0.02653421808929459,0.6273404177075236,0.20249673123855239,0.7654749150586566,0.11606903674900822,6399]
["High","Q9Y388","RNA-binding motif protein, X-linked 2 [OS=Homo sapiens]",10,4,10,4,322,37.3,9.83,19.58,"RNA metabolism OR transcription;other metabolic processes","nucleus","","RBMX2","ENSG00000134597","","","",869.4,657.3,645.4,593.6,600.6,585.1,1.220760973416512,0.28778074641480267,0.1469190116760553,0.8329220018151675,0.3068049326468681,0.5131376623107518,3739]
["High","Q9Y394","Dehydrogenase/reductase SDR family member 7 [OS=Homo sapiens]",9,2,3,2,339,38.3,8.32,2.66,"","","other molecular function","DHRS7","ENSG00000100612","","","",110.7,132.1,116.2,117.6,101.1,133.2,1.0201761864165957,0.02881832996074914,0.8439596990791209,0.07367829139026591,0.9106740368172714,0.04063704491940665,7236]
["High","Q9Y399","28S ribosomal protein S2, mitochondrial [OS=Homo sapiens]",18,6,9,6,296,33.2,9.26,9.57,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS2","ENSG00000122140","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",351.7,370.7,362.9,353,377.8,342,1.0116517524235646,0.016712747031795486,0.7446531568593022,0.12804596501976673,0.8500368199937766,0.07056226208124756,6840]
["High","Q9Y3A3","MOB-like protein phocein [OS=Homo sapiens]",46,7,35,7,225,26,5.78,49.95,"","other membranes;ER/Golgi;other cell component","other molecular function","MOB4","ENSG00000115540","","","",738.6,826.5,785.7,772.4,925.9,797.8,0.9417891911381756,-0.08652392988512708,0.4194046934606759,0.3773667137546349,0.6004238809206008,0.2215420427016106,5454]
["High","Q9Y3A4","Ribosomal RNA-processing protein 7 homolog A [OS=Homo sapiens]",29,7,16,7,280,32.3,9.58,27.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","","RRP7A","ENSG00000189306","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",776.5,706.7,796.9,866.3,783.4,707.9,0.9671275873769936,-0.04822186647384237,0.6530998914837747,0.1850203883997114,0.7840411981404233,0.10566111632708773,6504]
["High","Q9Y3A5","Ribosome maturation protein SBDS [OS=Homo sapiens]",61,20,70,20,250,28.7,8.75,104.87,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity","SBDS","ENSG00000126524","","","Ribosome biogenesis in eukaryotes",3773.3,3998,4023.1,3269.7,3450.3,3262.6,1.1814958026966922,0.2406145040985365,3.8455630724936692E-3,2.4150400612271397,0.03815267658199564,1.4184749889275685,787]
["High","Q9Y3A6-1","Transmembrane emp24 domain-containing protein 5 [OS=Homo sapiens]",12,3,5,3,229,26,4.84,9.42,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED5","ENSG00000117500","","WNT ligand biogenesis and trafficking","",256.4,251.4,247.4,200.8,214,228.5,1.1739468366236594,0.23136707601520282,0.011386492258747287,1.943610044779136,0.06546813811214935,1.1839700100649835,1358]
["High","Q9Y3B2","Exosome complex component csl4 [OS=Homo sapiens]",24,3,8,3,195,21.4,8.24,24.08,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EXOSC1","ENSG00000171311","","Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","RNA degradation",249.1,278.6,237.5,226.1,336.5,297.7,0.8894571661048473,-0.16900296408415322,0.41106421683351846,0.3860903269368142,0.5929409578858511,0.22698854936924018,5413]
["High","Q9Y3B3-1","Transmembrane emp24 domain-containing protein 7 [OS=Homo sapiens]",25,5,15,5,224,25.2,6.89,25.06,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED7","ENSG00000134970; ENSPTRG00000017152","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",735.2,938.7,767.3,587.8,822.7,773.1,1.1179703242352077,0.16088189332697292,0.4189386837025604,0.37784953617041533,0.5998667233357036,0.2219452291986012,5453]
["High","Q9Y3B4","Splicing factor 3B subunit 6 [OS=Homo sapiens]",34,4,4,4,125,14.6,9.38,8.97,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","SF3B6","ENSG00000115128","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",206.5,227.7,222.3,302.4,227.9,210.3,0.8864434242506077,-0.17389953839138042,0.38749511293929734,0.41173377041413484,0.5715077147393339,0.24297790272082878,5294]
["High","Q9Y3B6","ER membrane protein complex subunit 9 [OS=Homo sapiens]",8,1,1,1,208,23,5.91,3.52,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC9","ENSG00000100908; ENSG00000285377","","","",23.7,19.1,12.4,24.6,17.1,18.3,0.9199999999999999,-0.12029423371771195,0.7110593806869467,0.1480941297514811,0.8250782648838876,0.0835048533954759,6729]
["High","Q9Y3B7-1","39S ribosomal protein L11, mitochondrial [OS=Homo sapiens]",43,9,19,9,192,20.7,9.91,33.13,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL11","ENSG00000174547; ENSPPAG00000028194; ENSPTRG00000003924","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",949.9,967.4,996.8,899.6,984.1,988.8,1.0144821583986074,0.020743492776984326,0.6875661114623473,0.16268553682441902,0.8080247137715243,0.09257535594514048,6644]
["High","Q9Y3B8-1","Oligoribonuclease, mitochondrial [OS=Homo sapiens]",34,6,27,6,237,26.8,6.87,49.9,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","REXO2","ENSG00000076043; ENSPPAG00000039849; ENSPTRG00000004306","","","Ribosome biogenesis in eukaryotes",1119.3,1010.2,1134.9,1286.3,1023.5,1028.2,0.9779508687837029,-0.03216610736075026,0.8095003778315828,0.09178294420506922,0.8907242037921362,0.05025674637010378,7096]
["High","Q9Y3B9","RRP15-like protein [OS=Homo sapiens]",18,5,23,5,282,31.5,5.52,39.06,"RNA metabolism OR transcription;other metabolic processes","other cell component","","RRP15","ENSG00000067533","","","",895.8,910,924.1,1208.6,1025.6,1004.2,0.8429780138339923,-0.246433090939825,0.06050676449790415,1.2181960696468994,0.1726111864083433,0.7629310623983877,2737]
["High","Q9Y3C0","WASH complex subunit 3 [OS=Homo sapiens]",17,2,2,2,194,21.2,4.46,0,"cell organization and biogenesis;transport","other cytoplasmic organelle;other cell component","","WASHC3","ENSG00000120860","","","Endocytosis",21.7,19,24.8,24,18.1,23.1,1.004601226993865,0.006622942193734877,0.9698298982733216,0.01330443142386413,0.9835604423585004,7.1989463941670466E-3,7699]
["High","Q9Y3C1","nucleolar protein 16 [OS=Homo sapiens]",17,3,6,3,178,21.2,9.94,8.83,"other biological processes","nucleus;other cell component","","NOP16","ENSG00000048162","","","",218.8,225.6,239.3,410.1,273.7,258.7,0.7254111405835544,-0.4631291930569357,0.15015294399814327,0.823466148316055,0.3107326230420097,0.5076131488584151,3773]
["High","Q9Y3C4","EKC/KEOPS complex subunit TPRKB [OS=Homo sapiens]",14,2,9,2,175,19.6,6.79,12.12,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","TPRKB","ENSG00000144034","","tRNA modification in the nucleus and cytosol","",237.3,199.2,227.9,229,231.6,235.3,0.9547348757005316,-0.06682793411096997,0.4167161789172572,0.38015963782425144,0.5977806218971052,0.22345816748268985,5443]
["High","Q9Y3C5","Ring finger protein 11 [OS=Homo sapiens]",8,1,2,1,154,17.4,4.78,3.26,"protein metabolism;other metabolic processes","nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","RNF11","ENSG00000123091","","","",70.4,58.4,72.3,56.6,52.1,50.1,1.2663727959697735,0.3407021691623943,0.04138720225194722,1.3831339306325412,0.13692850643356097,0.8635061289440124,2360]
["High","Q9Y3C6","Peptidyl-prolyl cis-trans isomerase-like 1 [OS=Homo sapiens]",40,6,42,6,166,18.2,7.99,66.58,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","PPIL1","ENSG00000137168","","mRNA Splicing - Major Pathway","Spliceosome",2232,2157.9,2218.1,2439.8,2294.7,2322.2,0.9364150381906557,-0.09477999154713937,0.04021639185930658,1.3955968960934528,0.13465248183424777,0.8707856375217939,2332]
["High","Q9Y3C8","ubiquitin-fold modifier-conjugating enzyme 1 [OS=Homo sapiens]",26,5,12,5,167,19.4,7.4,25.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes","","other molecular function","UFC1","ENSG00000143222","","","",543.6,497.4,563.2,535.4,529.7,482,1.0369077629112535,0.052287566370136936,0.502054673293523,0.29924898600882366,0.6711253020160637,0.17319638758988234,5841]
["High","Q9Y3D0","Mitotic spindle-associated MMXD complex subunit MIP18 [OS=Homo sapiens]",26,2,2,2,163,17.7,5.19,7.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CIAO2B","ENSG00000166595","","Cytosolic iron-sulfur cluster assembly","",60.9,55.8,56.9,62.7,38.3,34.6,1.28023598820059,0.3564097693081355,0.22991695829905787,0.6384289946981621,0.41014201745465934,0.3870657366526407,4377]
["High","Q9Y3D2","Methionine-R-sulfoxide reductase B2, mitochondrial [OS=Homo sapiens]",21,2,3,2,182,19.5,8.63,5.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","MSRB2","ENSG00000148450","Sulindac metabolic pathway; Methionine de novo and salvage pathway","Protein repair","",39.5,30.8,40,31.4,25.4,36.3,1.184747583243824,0.24457971803258896,0.25720206852034194,0.5897255429664867,0.44040213837869074,0.35615058097228636,4560]
["High","Q9Y3D3","28S ribosomal protein S16, mitochondrial [OS=Homo sapiens]",23,2,4,2,137,15.3,9.5,7.77,"protein metabolism;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","other molecular function","MRPS16","ENSG00000182180","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",100,87.7,93.9,93.9,83.2,79.8,1.0961463604515376,0.1324404437364804,0.21121124788881737,0.675282957511457,0.3890392600886733,0.4100065694210426,4239]
["High","Q9Y3D6","mitochondrial fission 1 protein [OS=Homo sapiens]",12,2,9,2,152,16.9,8.79,17.75,"cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FIS1","ENSG00000214253","CAMKK2 pathway","Class I peroxisomal membrane protein import","Mitophagy",364.7,341.2,358.5,266,300.8,312.1,1.2110592786437593,0.2762694834569461,0.016459467197280826,1.7835842272662767,0.07957617329806112,1.099216949274763,1615]
["High","Q9Y3D8","Adenylate kinase isoenzyme 6 [OS=Homo sapiens]",56,5,10,5,172,20,4.58,15.84,"other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AK6","ENSG00000085231; ENSG00000279247","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Metabolic pathways; Biosynthesis of cofactors; Ribosome biogenesis in eukaryotes",233.5,264.2,257.9,268.6,292.7,259.7,0.9203410475030449,-0.11975952027679769,0.18406776157860255,0.7350222690437398,0.35547887271969547,0.44918620571877865,4043]
["High","Q9Y3D9","28S ribosomal protein S23, mitochondrial [OS=Homo sapiens]",11,2,3,2,190,21.8,8.9,7.9,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS23","ENSG00000181610","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",171.9,176.6,206.6,243,214.6,198,0.8467053081147041,-0.24006816133787623,0.12090335680068459,0.9175616410765647,0.2718932632199727,0.5656015529223837,3472]
["High","Q9Y3E0","vesicle transport protein GOT1B [OS=Homo sapiens]",17,3,44,3,138,15.4,10.36,91.96,"transport","other membranes;ER/Golgi;other cell component","","GOLT1B","ENSG00000111711","","","",2342.7,2382.3,2418.8,2581.7,2585.7,2482.8,0.9338056521398135,-0.09880577393480254,0.013697641509474211,1.8633542042010582,0.07120584880557566,1.1474843322105723,1502]
["High","Q9Y3E1","Hepatoma-derived growth factor-related protein 3 [OS=Homo sapiens]",30,5,21,4,203,22.6,7.99,36.17,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","HDGFL3","ENSG00000166503","","","",674.5,706.1,694.4,706.2,749.3,733.1,0.9480946723933108,-0.07689696764904369,0.07207144408022252,1.1422367759870553,0.19451567071495937,0.7110454049764028,2893]
["High","Q9Y3E5","Peptidyl-tRNA hydrolase 2, mitochondrial [OS=Homo sapiens]",21,2,5,2,179,19.2,8.73,12.87,"other biological processes","cytosol;mitochondrion","other molecular function","PTRH2","ENSG00000141378","Apoptosis modulation and signaling","Ub-specific processing proteases","",166.4,174.5,143.2,142.9,143.2,139,1.1387908727358267,0.18750283522168082,0.10658790405818341,0.9722920776626195,0.25014678535806917,0.6018050738728066,3327]
["High","Q9Y3E7","Charged multivesicular body protein 3 [OS=Homo sapiens]",9,2,4,2,222,25.1,5.12,5.58,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","CHMP3","ENSG00000115561","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Endocytosis; Necroptosis",79.4,70.3,66,68.2,74.9,74.1,0.9930939226519335,-0.009997926643907811,0.9165034271756434,0.037865906696649895,0.9541411679183232,0.020387365429714532,7500]
["High","Q9Y3F4","Serine-threonine kinase receptor-associated protein [OS=Homo sapiens]",68,21,239,21,350,38.4,5.12,565.03,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","STRAP","ENSG00000023734","TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer","Downregulation of TGF-beta receptor signaling","",8173.3,8197,8432.8,8540.5,8463,8673.1,0.9659806983790687,-0.049933732566480524,0.047593349807484135,1.3224537267686471,0.1493004721963986,0.8259388187186049,2489]
["High","Q9Y3I0","tRNA-splicing ligase RtcB homolog [OS=Homo sapiens]",56,25,115,25,505,55.2,7.23,254.71,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","RTCB","ENSG00000100220","Unfolded protein response","tRNA processing in the nucleus","",5729.6,5662.6,5703.1,5732.9,5701.4,5797.7,0.9920670844939649,-0.011490414603407481,0.2558721626524073,0.5919769601623049,0.43908787823955964,0.357448552160782,4550]
["High","Q9Y3L3-1","SH3 domain-binding protein 1 [OS=Homo sapiens]",15,8,16,8,701,75.7,6.77,35.16,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SH3BP1","ENSG00000100092","","RAC1 GTPase cycle","",570.5,547.7,537.9,662.6,614.5,642.8,0.8625970102609511,-0.21324137915018448,6.602085726715892E-3,2.1803188407451883,0.04928210836921385,1.3073107206178083,1046]
["High","Q9Y3M8-4","Isoform 4 of StAR-related lipid transfer protein 13 [OS=Homo sapiens]",3,3,3,2,1078,120.6,6.95,8.94,"","","","STARD13","","","","",109.9,115.9,103.5,106.2,97.6,128.3,0.9915688045769346,-0.012215210907360914,0.9288465892591621,0.03205600930014063,0.9617337447202676,0.01694514542972494,7541]
["High","Q9Y3P9","Rab GTPase-activating protein 1 [OS=Homo sapiens]",26,22,38,20,1069,121.7,5.25,80,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity;other molecular function","RABGAP1","ENSG00000011454","","TBC/RABGAPs","",1460,1394.6,1494.5,1221.1,1181,1205,1.2057054143217545,0.2698774617886393,1.4259076639930109E-3,2.845908596725863,0.025075421262291505,1.6007517621818474,444]
["High","Q9Y3Q3","Transmembrane emp24 domain-containing protein 3 [OS=Homo sapiens]",9,2,7,2,217,24.8,5.6,19.2,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED3","ENSG00000166557","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",409.3,466.3,405.5,420.9,499.5,430.6,0.948260547742413,-0.07664458081600233,0.5018862343699173,0.2993947158923012,0.6712448985886116,0.17311900188566137,5838]
["High","Q9Y3Q4","Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [OS=Homo sapiens]",2,2,2,2,1203,129,8.91,2.14,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","HCN4","ENSG00000138622","Genes targeted by miRNAs in adipocytes","HCN channels","cAMP signaling pathway; Taste transduction",42.2,38.2,44.7,43.1,39.3,44.6,0.9850393700787402,-0.021746707493708335,0.8098293452446674,0.09160649004362441,0.8905841588268117,0.05032503410406428,7100]
["High","Q9Y3R0","Glutamate receptor-interacting protein 1 [OS=Homo sapiens]",4,3,4,3,1128,122.3,6.47,2.15,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","GRIP1","ENSG00000155974","Brain-derived neurotrophic factor (BDNF) signaling pathway; Fragile X syndrome; 7q11.23 copy number variation syndrome; Development of ureteric collection system","Trafficking of GluR2-containing AMPA receptors","",19.3,15.4,20.7,17.5,15.4,18,1.088408644400786,0.12222031997349336,0.44554023839384016,0.35111306710802337,0.6252297234685665,0.20396038376939676,5564]
["High","Q9Y3R5-1","Protein dopey-2 [OS=Homo sapiens]",3,5,5,5,2298,258.1,6.29,4.3,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","DOP1B","ENSG00000142197","","","",121,134.7,115.6,87.1,106.9,88,1.3166666666666664,0.3968901525685842,0.025802034900948238,1.5883460416567932,0.10278688189112441,0.9880623083546338,1960]
["High","Q9Y3S1-1","Serine/threonine-protein kinase WNK2 [OS=Homo sapiens]",12,25,42,17,2297,242.5,6.13,74.88,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","WNK2","ENSG00000165238","","Stimuli-sensing channels","",1957.8,1848.4,1832.3,1733.5,1775,1722.4,1.0779215813722305,0.10825222606765117,0.033119412343110326,1.4799173777569838,0.11911394360893848,0.9240373965527684,2171]
["High","Q9Y3S2","zinc finger protein 330 [OS=Homo sapiens]",24,7,19,7,320,36.2,6.16,30.55,"","nucleus;other cell component","other molecular function","ZNF330","ENSG00000109445","","","",614.5,635.2,591.4,686,648.6,631.6,{"$f":"AVERAGE(T7618:V7618)/AVERAGE(W7618:Y7618)","v":0.9363747329874885},{"$f":"LOG(Z7618,2)","v":-0.09484208940524949},{"$f":"TTEST(T7618:V7618,W7618:Y7618,2,2)","v":0.11105494366634056},{"$f":"-LOG10(AB7618)","v":0.9544621038491964},{"$f":"AB7618*7808/AF7618","v":0.25707589687126803},{"$f":"-LOG10(AD7618)","v":0.5899386403797624},3373]
["High","Q9Y3T6","R3H and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",10,4,5,4,440,49.1,5.63,11.19,"","","nucleic acid binding activity","R3HCC1","ENSG00000104679","","","",229.2,275.6,184.6,195.5,242.6,179.7,1.11589511168663,0.15820142773963183,0.5017057450565987,0.29955092581679,0.6711184610933567,0.17320081446831448,5837]
["High","Q9Y3T9","Nucleolar complex protein 2 homolog [OS=Homo sapiens]",27,18,61,18,749,84.9,5.62,100.48,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","other molecular function","NOC2L","ENSG00000188976","","Regulation of TP53 Activity through Phosphorylation","",2649.8,2685.8,2532.8,2497.6,2806.9,2703.2,0.9826042434157125,-0.02531762544876101,0.6724092300679402,0.1723663336917258,0.7975347513854592,0.09825038412516916,6583]
["High","Q9Y3U8","60S ribosomal protein L36 [OS=Homo sapiens]",21,2,9,2,105,12.2,11.59,23.05,"protein metabolism;other metabolic processes","cytosol;translational apparatus;nucleus","other molecular function","RPL36","ENSG00000130255","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",417.6,425.5,427.8,454.2,397.3,369.8,1.0406124621305168,0.057432889907772226,0.5452107877594138,0.26343555962746873,0.704452396297452,0.15214834921728979,6043]
["High","Q9Y3X0","coiled-coil domain-containing protein 9 [OS=Homo sapiens]",11,5,7,5,531,59.7,5.4,15.69,"","","","CCDC9","ENSG00000105321","IL-18 signaling pathway","","",200,200.7,193.9,375.9,273.4,202.5,0.6980511857243485,-0.518595266642693,0.1640141230182717,0.7851187538741305,0.3298872417636954,0.48163448026783917,3882]
["High","Q9Y3Z3","deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [OS=Homo sapiens]",40,24,80,24,626,72.2,7.14,136.63,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMHD1","ENSG00000101347","","Interferon alpha/beta signaling; Nucleotide catabolism","Human immunodeficiency virus 1 infection",2922.5,2940.1,2952.1,2893.3,2852.4,2808.5,1.0304528769493349,0.04327853132456805,0.028669530159686776,1.5425794242745616,0.10893026349724298,0.9628514458280143,2055]
["High","Q9Y426","C2 domain-containing protein 2 [OS=Homo sapiens]",10,4,6,4,696,75.5,6.92,13.35,"","other membranes","","C2CD2","ENSG00000157617","","","",125.9,129.6,118.9,135.8,158.7,137.3,0.8670680870773506,-0.2057828084391008,0.0758605928952304,1.1199837673527024,0.20058229235555672,0.6977074096591456,2953]
["Low","Q9Y448","Small kinetochore-associated protein [OS=Homo sapiens]",2,1,1,1,316,35.4,6.3,1.83,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KNSTRN","ENSG00000128944","Leukocyte-intrinsic Hippo pathway functions","","",74.1,77,76.6,120.7,78.4,68.1,0.8521706586826345,-0.23078571633743006,0.4598820418340944,0.33735354907921755,0.6373374126092668,0.1956305870703367,5634]
["High","Q9Y450-1","HBS1-like protein [OS=Homo sapiens]",28,15,37,15,684,75.4,6.61,87.73,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol","nucleic acid binding activity;other molecular function","HBS1L","ENSG00000112339","","mRNA decay by 3' to 5' exoribonuclease","mRNA surveillance pathway; Legionellosis",1332.4,1388.1,1348,1412.7,1355.3,1368.1,0.9836561011580958,-0.023774075941084976,0.4016380124275127,0.39616519076773676,0.583657100508844,0.23384222667779536,5373]
["Medium","Q9Y458-1","T-box transcription factor TBX22 [OS=Homo sapiens]",2,1,2,1,520,57.9,7.33,2.14,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TBX22","ENSG00000122145; ENSG00000277800","","","",70.7,61.1,74.3,71.9,45.8,53.6,1.203152364273205,0.26681935345525737,0.25239103387137624,0.5979260773571828,0.43502631180302553,0.36148447471137923,4530]
["High","Q9Y462","Zinc finger protein 711 [OS=Homo sapiens]",4,2,2,2,761,86.2,6.87,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF711","ENSG00000147180","","Generic Transcription Pathway","",43.8,39.2,44.1,41.9,37.1,41.2,1.057404326123128,0.08052713429377341,0.351055947341966,0.454623665056542,0.5371438049864924,0.269909428730138,5103]
["High","Q9Y467","sal-like protein 2 [OS=Homo sapiens]",24,14,35,13,1007,105.2,6.3,102.72,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SALL2","ENSG00000165821","","","",1298.5,1368.3,1411,1683.9,1577.8,1593,0.8399695140791398,-0.25159112733521843,5.1360479721098565E-3,2.2893709284895736,0.043589415832862785,1.3606189511764932,920]
["High","Q9Y467-3","Isoform 2 of Sal-like protein 2 [OS=Homo sapiens]",13,1,3,1,198,20.9,4.77,9.61,"","","","SALL2","","","","",60.2,67.5,62.1,87,60.7,70,0.8718419843821774,-0.19786141516709707,0.30988899458766406,0.5087938470415135,0.4967385074400495,0.30387217195464805,4871]
["High","Q9Y478","5'-AMP-activated protein kinase subunit beta-1 [OS=Homo sapiens]",11,2,2,2,270,30.4,6.4,5.7,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","PRKAB1","ENSG00000111725","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma","Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy",128.4,112,128.9,126,117.5,125.9,0.9997292907417435,-0.000390603776824385,0.995984330327546,1.7474942126594478E-3,0.9984138722810989,6.8939339354403119E-4,7789]
["High","Q9Y483","Metal-response element-binding transcription factor 2 [OS=Homo sapiens]",9,4,4,4,593,67.1,8.72,8.81,"","","","","","","","",181.4,182.3,172.3,213,210.3,221.6,0.8311366103271824,-0.26684246886225893,0.001476826870088086,2.83067041448662,0.025287421494841616,1.5970954524924195,456]
["High","Q9Y484-1","WD repeat domain phosphoinositide-interacting protein 4 [OS=Homo sapiens]",3,1,1,1,360,39.8,7.14,2.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;other cell component","other molecular function","WDR45","ENSCANG00000035794; ENSCSAG00000012964; ENSG00000196998; ENSGGOG00000000589; ENSMFAG00000032970; ENSMLEG00000042347; ENSMMUG00000010620","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway","Macroautophagy","",91.3,79.5,80,94.7,82.7,91.3,0.9333829549683663,-0.09945897321112698,0.31945771625653885,0.495586617354463,0.5063592871561217,0.295541220198912,4926]
["High","Q9Y485","DmX-like protein 1 [OS=Homo sapiens]",5,10,10,9,3027,337.6,6.34,18.22,"other biological processes","other cell component","","DMXL1","ENSG00000172869","","","Lysosome",339,353.2,326.7,364.7,410.9,380.2,0.8815539020591799,-0.18187930996357127,0.0429023988988396,1.3675184234469522,0.14004261312798477,0.85373979410469,2392]
["High","Q9Y487","V-type proton ATPase 116 kDa subunit a isoform 2 [OS=Homo sapiens]",20,13,19,12,856,98,6.61,26.08,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V0A2","ENSG00000185344","","Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; ROS and RNS production in phagocytes","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Human papillomavirus infection; Rheumatoid arthritis",519,524,523.3,519.2,554.5,495.3,0.9982791586998089,-2.4847877863757475E-3,0.9609274107250245,0.017309418067411448,0.9791101687251718,0.009168438965462345,7663]
["High","Q9Y490","Talin-1 [OS=Homo sapiens]",61,118,456,100,2541,269.6,6.07,1103.31,"cell adhesion;cell organization and biogenesis;signal transduction","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN1","ENSG00000137076","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion","Signaling by BRAF and RAF1 fusions; p130Cas linkage to MAPK signaling for integrins; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Platelet degranulation ; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection",18415.4,18162.2,18380.1,18608.7,18607.5,18838.2,0.9804350773534282,-0.028505993976617326,0.029481537825037183,1.530449866419883,0.11077567244364309,0.955555604982406,2078]
["High","Q9Y496","kinesin-like protein KIF3A [OS=Homo sapiens]",11,7,8,7,699,80,6.54,14.44,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3A","ENSG00000131437","Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO","Hedgehog signaling pathway",373,325.5,328.8,346.4,326.4,315.2,1.0397773279352227,0.0562746030977714,0.503165768890844,0.29828891225176873,0.6714610021363373,0.17297920570385164,5851]
["High","Q9Y4A5","Transformation/transcription domain-associated protein [OS=Homo sapiens]",15,43,73,43,3859,437.3,8.19,147.48,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus","other molecular function","TRRAP","ENSG00000196367","Rett syndrome causing genes","Ub-specific processing proteases; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex","Human T-cell leukemia virus 1 infection",2438.5,2478.3,2370.7,2393.3,2543,2515,0.9780172587333752,-0.03206817074322928,0.3821512365338808,0.41776473082198173,0.5660855349756292,0.2471179423783037,5271]
["High","Q9Y4A8","nuclear factor erythroid 2-related factor 3 [OS=Homo sapiens]",2,1,1,1,694,76.1,5.44,3.21,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFE2L3","ENSG00000050344","","","",19.3,24.4,21.6,41.2,41,44.2,0.516613924050633,-0.9528415666306719,3.4892219860473378E-4,3.457271399640851,0.014115982003656794,1.8502889039899892,193]
["High","Q9Y4B4","Helicase ARIP4 [OS=Homo sapiens]",11,12,19,12,1467,162.7,6.09,39.73,"cell organization and biogenesis","nucleus","nucleic acid binding activity;other molecular function","RAD54L2","ENSG00000164080","","","",873.4,820.7,828.1,869.2,745.7,782,1.052275856314406,0.07351295973196623,0.3572665232130851,0.4470076763947286,0.5423949082729473,0.26568439605718336,5143]
["High","Q9Y4B5","Microtubule cross-linking factor 1 [OS=Homo sapiens]",4,6,8,3,1905,209.4,6.43,15.27,"cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MTCL1","ENSG00000168502","","","",75.9,53.7,65.9,73.5,69.3,67.8,0.9283000949667617,-0.10733682883100217,0.49075277614595464,0.30913723495473383,0.6629407744200024,0.17852526871662744,5780]
["High","Q9Y4B6","DDB1- and CUL4-associated factor 1 [OS=Homo sapiens]",14,17,28,17,1507,168.9,5.06,41.4,"protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","DCAF1","ENSG00000145041","Hippo-Merlin signaling dysregulation","Antigen processing: Ubiquitination & Proteasome degradation","Human immunodeficiency virus 1 infection",848.8,800.9,776.9,900.9,898,923.8,0.8912476585742095,-0.16610171347705116,0.01209379720895113,1.9174373179999542,0.06725667279735785,1.1722646211351053,1404]
["High","Q9Y4C1","Lysine-specific demethylase 3A [OS=Homo sapiens]",18,18,28,17,1321,147.2,8.07,66.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3A","ENSG00000115548","Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; HDMs demethylate histones","Thermogenesis",819.3,753.6,793.8,598.2,525.1,631.9,1.3483933454876935,0.4312414125477883,0.005229534913501977,2.281536933213249,0.044095257672379526,1.3556081152365478,926]
["High","Q9Y4C2-1","TRPM8 channel-associated factor 1 [OS=Homo sapiens]",17,10,38,10,921,102.1,6.54,88.55,"other biological processes","plasma membrane;other membranes","other molecular function","TCAF1","ENSG00000198420","","","",1336.1,1245.9,1278.6,637.2,642.7,658.5,1.9916425918283118,0.9939587732794299,1.9047573519774931E-5,4.720160341463,0.004957448468080089,2.3047417915240267,30]
["Medium","Q9Y4C4","Malignant fibrous histiocytoma-amplified sequence 1 [OS=Homo sapiens]",1,1,1,1,1052,116.9,7.88,0,"stress response;developmental processes;other biological processes","other cell component","other molecular function","MFHAS1","ENSG00000147324","","","",16.6,26.6,18.1,15.7,25.4,19.6,1.0098846787479407,0.014190557435099503,0.9642980824446739,0.01578869685416804,0.9810083944922493,0.008327276344756739,7675]
["High","Q9Y4C5-1","Carbohydrate sulfotransferase 2 [OS=Homo sapiens]",4,2,2,2,530,57.8,9.98,2.4,"other metabolic processes;stress response;developmental processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","CHST2; HEL-S-75","ENSG00000175040; ENSPTRG00000043559","Metapathway biotransformation Phase I and II","Keratan sulfate biosynthesis","Glycosaminoglycan biosynthesis",136.5,137.5,138.5,136.4,128.2,139.9,1.0197775030902347,0.028254416703200398,0.4902924185020195,0.3095448222916445,0.6624335012396207,0.1788577120993921,5779]
["High","Q9Y4C8","Probable RNA-binding protein 19 [OS=Homo sapiens]",28,23,42,23,960,107.3,6.54,86.59,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","RBM19","ENSG00000122965","","","",2092.3,2165.3,2164.8,2064.6,2186.4,2178.4,0.9989112514387036,-1.5715878374835477E-3,0.9621488360774746,0.01675774117697345,0.9794599885388424,0.009013300467319024,7670]
["High","Q9Y4D1","Disheveled-associated activator of morphogenesis 1 [OS=Homo sapiens]",9,10,10,10,1078,123.4,7.23,14.3,"cell-cell signaling;cell organization and biogenesis;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","DAAM1","ENSG00000100592","Physico-chemical features and toxicity-associated pathways; Wnt signaling","RHO GTPases Activate Formins; RHOA GTPase cycle; PCP/CE pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle","Wnt signaling pathway",421.2,388.1,396.5,327.9,312.6,333.4,1.238114796180306,0.3081450853130605,0.002739127543421173,2.5623877449952577,0.032016628531485805,1.494624402812168,668]
["High","Q9Y4D8-1","Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",3,8,10,7,3996,439.1,6.19,14.21,"protein metabolism;other metabolic processes;other biological processes","other membranes","other molecular function","HECTD4","","","","",124.5,143.6,140.2,118.8,132,135.7,1.05640362225097,0.07916115341294087,0.40451836991918183,0.393061751496989,0.5863150978891724,0.23186892238430862,5387]
["High","Q9Y4E1","WASH complex subunit 2C [OS=Homo sapiens]",28,24,45,6,1318,144.6,4.79,72.31,"","","","","","","","",95.6,87.4,86,125.7,105.3,112.2,0.7837995337995339,-0.35144338005555886,0.020963444830976573,1.6785373501159788,0.09063265627921654,1.0427152914348305,1806]
["High","Q9Y4E5","E3 SUMO-protein ligase ZNF451 [OS=Homo sapiens]",14,13,18,13,1061,121.4,6.77,38.79,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","ZNF451","ENSG00000112200","","","",830.9,828.2,754.1,740.6,751.9,750.1,1.0760724159457773,0.10577516953989208,0.08877954895050083,1.0516870657626252,0.2228909061754053,0.6519076501308273,3110]
["High","Q9Y4E8","ubiquitin carboxyl-terminal hydrolase 15 [OS=Homo sapiens]",31,25,59,23,981,112.3,5.22,110.07,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","USP15","ENSG00000135655","","Ub-specific processing proteases; UCH proteinases; Downregulation of TGF-beta receptor signaling","Mitophagy",2181.5,2214.2,2272.8,2225,2109.2,2134.7,1.0308553231615887,0.04384186985103303,0.20611763668553185,0.6858848457389884,0.3829089952987468,0.41690443108579006,4203]
["High","Q9Y4F1","FERM, RhoGEF and pleckstrin domain-containing protein 1 [OS=Homo sapiens]",13,10,15,10,1045,118.6,8.15,31.63,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","FARP1","ENSG00000152767","","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOA GTPase cycle; RHOF GTPase cycle","",672.7,678.4,663.3,667.1,706.6,707.8,0.9677636319961564,-0.047273370308564315,0.18729308569359024,0.7274782551957575,0.35913173209615734,0.4447462198658244,4072]
["High","Q9Y4F5","Centrosomal protein of 170 kDa protein B [OS=Homo sapiens]",8,11,13,9,1589,171.6,6.84,26.46,"","cytoskeleton;other cell component","","CEP170B","ENSG00000099814","","","",429.2,419.1,404.3,407.6,340.8,384.2,1.1059509094119724,0.14528734911718869,0.12766600087662558,0.8939247456311565,0.28142748019330677,0.5506334978265771,3542]
["High","Q9Y4G6","Talin-2 [OS=Homo sapiens]",34,72,166,53,2542,271.4,5.57,360.2,"cell adhesion;cell organization and biogenesis","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN2","ENSG00000171914","Focal adhesion","","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection",4014.2,4020.8,3944,3531,3380.1,3381.7,1.1638232550909375,0.21887197889492813,5.4431073540832722E-4,3.2641531000341666,0.016732197724678027,1.7764470119954694,254]
["High","Q9Y4G8","rap guanine nucleotide exchange factor 2 [OS=Homo sapiens]",4,4,6,3,1499,167.3,6.67,7.87,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RAPGEF2","ENSG00000109756","MAPK signaling pathway","RAF/MAP kinase cascade","MAPK signaling pathway; Rap1 signaling pathway; Tight junction",39.3,35.4,28.2,27,26.6,31.8,1.2049180327868851,0.268935007273478,0.1857523193377054,0.731065754852563,0.35731808558482475,0.44694500151121297,4059]
["High","Q9Y4H2","Insulin receptor substrate 2 [OS=Homo sapiens]",6,7,8,7,1338,137.2,8.65,17,"other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","IRS2","ENSG00000185950","Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Nonalcoholic fatty liver disease; Insulin signaling; FOXA2 pathway; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways","PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF/MAP kinase cascade; Growth hormone receptor signaling; Interleukin-7 signaling; Signaling by Leptin; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); PI3K Cascade; PI3K/AKT activation; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; SOS-mediated signalling; IRS activation; Signal attenuation","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Alzheimer disease; MicroRNAs in cancer",408.3,403,420.2,369.9,342.7,333.3,1.1774548235969025,0.23567170780151922,0.006910257421538922,2.160505773946855,0.05023770013722151,1.2989702506517566,1074]
["High","Q9Y4I1-1","Unconventional myosin-Va [OS=Homo sapiens]",10,15,19,11,1855,215.3,8.48,27.22,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5A","ENSG00000197535","Joubert syndrome","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing","Pathogenic Escherichia coli infection",834.4,815.3,825,763.3,789.8,742.2,1.0781597176839628,0.10857091356569608,0.015714428646891213,1.8037014046567879,0.07746102201699911,1.1109167772516273,1584]
["High","Q9Y4I5","Tesmin [OS=Homo sapiens]",10,3,3,3,508,55,5.71,5.92,"other biological processes","nucleus;other cell component","other molecular function","TESMIN","ENSG00000132749","","","",51,42.9,54.8,72,52.6,59.8,0.8063991323210412,-0.3104340083769193,0.148563250615541,0.8280886066501579,0.30908123122998776,0.5099273664046049,3753]
["High","Q9Y4K0","Lysyl oxidase homolog 2 [OS=Homo sapiens]",8,5,7,5,774,86.7,6.38,16.64,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","LOXL2","ENSG00000134013","Canonical and non-canonical TGF-B signaling","Crosslinking of collagen fibrils; Elastic fibre formation","",243.8,251.1,255.4,255.5,238.1,227.5,1.0404936901955346,0.057268216249400546,0.3324990420514715,0.47820960158601694,0.5199584458918265,0.28403136298249126,4993]
["High","Q9Y4K3","TNF receptor-associated factor 6 [OS=Homo sapiens]",19,6,9,6,522,59.5,6.44,15.13,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TRAF6","ENSG00000175104","IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; T-cell receptor (TCR) signaling pathway; Toll-like receptor signaling pathway","Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; TRAF6 mediated NF-kB activation; Ovarian tumor domain proteases; TRAF6 mediated IRF7 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PIP3 activates AKT signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","MAPK signaling pathway; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; Autophagy; Endocytosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; Neurotrophin signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",111.4,113.7,109.2,109.7,98,103.3,1.07491961414791,0.10422877459943852,0.09870060734546898,1.0056801749294084,0.2382975702391533,0.6228803858411552,3234]
["High","Q9Y4K4","mitogen-activated protein kinase kinase kinase kinase 5 [OS=Homo sapiens]",12,7,15,7,846,95,7.64,13.31,"","","","","","","","",370.2,369.6,371.2,404.2,376.7,426.2,0.920387706072405,-0.11968638175868138,0.0890193861204943,1.0505154049467913,0.22313430716816038,0.6514336512833444,3115]
["High","Q9Y4L1","Hypoxia up-regulated protein 1 [OS=Homo sapiens]",61,48,364,48,999,111.3,5.22,807.97,"stress response;transport;other biological processes","non-structural extracellular;ER/Golgi;other cell component","other molecular function","HYOU1","ENSG00000149428; ENSG00000280682","VEGFA-VEGFR2 signaling pathway","XBP1(S) activates chaperone genes; Scavenging by Class F Receptors","Protein processing in endoplasmic reticulum",14049.3,13124.4,14092.4,13883.8,12869.7,13655.9,1.0212005127519834,0.03026616724521153,0.5521426137214962,0.2579487332259002,0.708834187428057,0.14945534437537808,6082]
["High","Q9Y4L5","E3 ubiquitin-protein ligase RNF115 [OS=Homo sapiens]",11,2,2,2,304,33.7,5.69,6.65,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","RNF115","ENSG00000265491","","Antigen processing: Ubiquitination & Proteasome degradation","",60.3,57.9,57.6,66.8,61.9,69.2,0.8883274381000507,-0.17083654190410782,0.03332610083417833,1.4772154959782313,0.11936247491434145,0.9231321849242007,2180]
["High","Q9Y4P1-1","Cysteine protease ATG4B [OS=Homo sapiens]",27,7,28,7,393,44.3,5.07,63.67,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol","other molecular function","ATG4B","ENSG00000168397","","Macroautophagy","Autophagy; Autophagy",548.6,470,507.3,531.7,520.4,508.7,0.977639671963096,-0.03262526494437018,0.6485770975591112,0.18803839112297646,0.7810132599848149,0.10734159264081847,6484]
["High","Q9Y4P3","Transducin beta-like protein 2 [OS=Homo sapiens]",25,12,21,12,447,49.8,9.44,35.73,"stress response;signal transduction","other membranes;ER/Golgi","other molecular function","TBL2","ENSG00000106638","7q11.23 copy number variation syndrome","","",930.7,949.3,887.4,924.1,965.3,907.2,0.9895587499106056,-0.015142732547779182,0.7187548571114033,0.1434192074716306,0.8306746483608403,0.08056904371196626,6756]
["High","Q9Y4P8-1","WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",23,6,9,1,454,49.4,6.46,22.96,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","WIPI2","ENSG00000157954","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease","Macroautophagy","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis",355.4,404,401.4,308.3,393.9,358.8,1.094062205466541,0.1296947682646173,0.3215641353867806,0.49273239484952813,0.5084594510125522,0.2937436757868062,4938]
["High","Q9Y4P8-6","Isoform 6 of WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",24,6,9,1,443,48.2,6.3,21.67,"","","","WIPI2","","","","",24.8,28.3,21,23.6,25,23.5,1.027739251040222,0.03947428306501133,0.7732847387528714,0.11166056080451542,0.8682495312312942,0.061355442493119645,6954]
["High","Q9Y4R8","telomere length regulation protein TEL2 homolog [OS=Homo sapiens]",23,15,27,15,837,91.7,5.76,55.26,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TELO2","ENSG00000100726","Fragile X syndrome; Malignant pleural mesothelioma","","Fanconi anemia pathway; mTOR signaling pathway",670.3,689.6,645,716.4,715.8,763.1,0.9132692570491507,-0.1308878255429859,0.035325555062666436,1.4519110054522484,0.12385358506030512,0.9070914178276511,2227]
["Low","Q9Y4U1","Methylmalonic aciduria and homocystinuria type C protein [OS=Homo sapiens]",3,1,1,1,282,31.7,7.81,0,"other metabolic processes","cytosol;other cell component","other molecular function","MMACHC","ENSG00000132763","","Cobalamin (Cbl, vitamin B12) transport and metabolism; Defective MMADHC causes MMAHCD; Defective MMACHC causes MAHCC","Vitamin digestion and absorption",18.1,24.1,26.4,25.4,32.7,26.6,0.8099173553719007,-0.30415339315938655,0.1845153810911588,0.7339674254691972,0.35599112813436323,0.44856082520212853,4047]
["High","Q9Y4W2","Ribosomal biogenesis protein LAS1L [OS=Homo sapiens]",44,25,55,25,734,83,4.73,103.69,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LAS1L","ENSG00000001497","","Major pathway of rRNA processing in the nucleolus and cytosol","",2334.3,2459.4,2351.2,2581.5,2608.2,2526.7,0.9259369654242913,-0.1110141117313732,0.01430617761614461,1.8444763873418712,0.07296057140878975,1.1369117733814968,1531]
["High","Q9Y4W6","AFG3-like protein 2 [OS=Homo sapiens]",29,22,59,21,797,88.5,8.66,131.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","AFG3L2","ENSG00000141385","Ciliary landscape","Processing of SMDT1","Spinocerebellar ataxia",2743.7,2965.2,2962.8,2966.1,3029.5,3013.7,0.9625276103581856,-0.0551001695114103,0.21215218064402872,0.6733524999011292,0.3898527245160217,0.40909942633200824,4249]
["High","Q9Y4X0","AMME syndrome candidate gene 1 protein [OS=Homo sapiens]",10,3,4,2,333,35.4,8.63,6.99,"","mitochondrion;nucleus","","AMMECR1","ENSG00000101935","","","",136.7,141,147.6,132,161.2,138.8,0.9844907407407406,-0.02255045742506746,0.8233857244602225,0.08439666690119488,0.8991602428790793,0.046162904043640145,7150]
["High","Q9Y4X5","E3 ubiquitin-protein ligase ARIH1 [OS=Homo sapiens]",37,15,42,15,557,64.1,5.08,85.92,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ARIH1","ENSG00000166233","","ISG15 antiviral mechanism","",1529.8,1473.4,1483.2,1428.7,1398.7,1422.7,1.055598691795487,0.07806146784452175,0.01605651536080097,1.7943487008867829,0.07825797249508987,1.1064714079763665,1602]
["High","Q9Y4Y9","U6 snRNA-associated Sm-like protein LSm5 [OS=Homo sapiens]",32,2,2,2,91,9.9,4.54,0,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM5","ENSG00000106355","","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",123.2,106.6,112.7,124.7,116.7,117.9,0.9532424158085167,-0.0690849472669126,0.36226874473037873,0.4409691337453917,0.5469053284715385,0.26208784529511275,5172]
["Low","Q9Y4Z0","U6 snRNA-associated Sm-like protein LSm4 [OS=Homo sapiens]",5,1,1,1,139,15.3,9.99,2.19,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM4","ENSG00000130520","Ciliary landscape","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",117.3,111.4,119.6,149.4,113.4,115.5,0.9206978588421885,-0.11920030346265378,0.44867180943503854,0.3480712168306822,0.6280440100517715,0.20200992210207783,5578]
["High","Q9Y508-1","E3 ubiquitin-protein ligase RNF114 [OS=Homo sapiens]",27,5,13,5,228,25.7,7.25,31.58,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","RNF114","ENSG00000124226; ENSPPAG00000043607; ENSPTRG00000013613","","Antigen processing: Ubiquitination & Proteasome degradation","",512.7,521.3,504.7,498.8,443.6,454.7,1.101352802233197,0.13927668915698926,0.05447593200240198,1.263795330883674,0.1609338165246896,0.7933526893567491,2643]
["High","Q9Y512","sorting and assembly machinery component 50 homolog [OS=Homo sapiens]",33,13,45,13,469,51.9,6.9,78.11,"cell organization and biogenesis;transport","other membranes;mitochondrion","","SAMM50","ENSG00000100347","","RAC2 GTPase cycle; Mitochondrial protein import; Cristae formation","",1257.9,1277.5,1293.7,1199.6,1360,1327.4,0.9851041934653975,-0.021651769865579797,0.7193008701859559,0.14308941430406533,0.8309367057866465,0.08043205608892319,6759]
["High","Q9Y520","Protein Prrc2c [OS=Homo sapiens]",27,63,184,62,2896,316.7,9.13,350.47,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;other cell component","other molecular function","PRRC2C","ENSG00000117523","VEGFA-VEGFR2 signaling pathway","","",8183,8393.9,8604.5,10781.8,8622.3,9147.1,0.8819734371935333,-0.18119288877150194,0.1647521928383598,0.7831687962710598,0.3308603708029612,0.48035524786666145,3888]
["High","Q9Y530","O-acetyl-ADP-ribose deacetylase 1 [OS=Homo sapiens]",14,2,3,2,152,17,8.31,5.34,"protein metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","OARD1","ENSG00000124596","","","",149.9,107.4,135.9,140.1,130.6,140.8,0.9555285540704741,-0.06562910896840707,0.6616710472157926,0.179357868393301,0.7905627447071015,0.10206365565122873,6535]
["High","Q9Y535","DNA-directed RNA polymerase III subunit RPC8 [OS=Homo sapiens]",27,3,4,3,204,22.9,4.58,7.21,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR3H","ENSG00000100413","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",86.7,111,90.6,114.3,113.2,109.1,0.8565062388591799,-0.2234643398350427,0.10468828891329655,0.9801018985007284,0.24762379879885474,0.6062076181724044,3301]
["High","Q9Y546","Leucine-rich repeat-containing protein 42 [OS=Homo sapiens]",7,3,3,3,428,48.5,7.46,8.42,"","","","LRRC42","ENSG00000116212","","","",184.4,172.8,189.2,273.3,275.9,285.6,{"$f":"AVERAGE(T7682:V7682)/AVERAGE(W7682:Y7682)","v":0.6545280306660277},{"$f":"LOG(Z7682,2)","v":-0.6114731168697448},{"$f":"TTEST(T7682:V7682,W7682:Y7682,2,2)","v":9.7217534022457793E-5},{"$f":"-LOG10(AB7682)","v":4.012255399246065},{"$f":"AB7682*7808/AF7682","v":0.00852892702974551},{"$f":"-LOG10(AD7682)","v":2.069105601232343},89]
["High","Q9Y547","Intraflagellar transport protein 25 homolog [OS=Homo sapiens]",42,4,11,4,144,16.3,5.03,29.53,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","HSPB11","ENSG00000081870","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis","Intraflagellar transport","",197.1,241.2,177.1,219.1,238.6,225.9,0.9002340550029256,-0.15162795334259468,0.31444342952692467,0.5024574756691363,0.501772797413903,0.2994928867704392,4893]
["High","Q9Y548","Protein YIPF1 [OS=Homo sapiens]",6,2,4,2,306,34.3,5.31,12.28,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","YIPF1","ENSG00000058799","","","",271.7,296.3,274.3,247.6,253.3,268,1.0954610482507476,0.13153818675209578,0.06866249555476224,1.1632804160869843,0.18771595423374773,0.7264988145324858,2856]
["High","Q9Y570","Protein phosphatase methylesterase 1 [OS=Homo sapiens]",41,14,44,14,386,42.3,5.97,87.1,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","nucleus","enzyme regulator activity;other molecular function","PPME1","ENSG00000214517","","Cyclin A/B1/B2 associated events during G2/M transition","",1684.8,1719,1705.7,1649.5,1713.7,1695.1,1.010121977739557,0.014529516793364927,0.4719881077156675,0.3260689437780483,0.6475633711200022,0.18871772472773787,5691]
["High","Q9Y573-1","actin-binding protein IPP [OS=Homo sapiens]",3,2,2,2,584,65.2,5.73,2.39,"","cytoskeleton;other cell component","cytoskeletal activity","IPP","ENSG00000197429; ENSPPAG00000037424","","","",125.9,116.7,115.9,116,122.5,120.1,0.9997211377579475,-0.000402369279107879,0.9932932490399364,2.9225162192653815E-3,0.9964838350897884,1.5297420094010313E-3,7783]
["High","Q9Y575","Ankyrin repeat and SOCS box protein 3 [OS=Homo sapiens]",2,1,3,1,518,57.7,6.27,5.21,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","","ASB3","ENSG00000115239","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",22.7,24,32.5,27.5,27.2,38.4,0.8506981740064448,-0.23328073747918399,0.38886110176521,0.4102054976692662,0.572657012935262,0.24210541640770541,5302]
["High","Q9Y576","Ankyrin repeat and SOCS box protein 1 [OS=Homo sapiens]",3,1,1,1,335,37,8.21,2.49,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","","ASB1","ENSG00000065802","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",46.4,80.6,55.8,47.8,74.7,63.4,0.9833243679397526,-0.024260699861411748,0.9397242552104077,0.026999563430815863,0.9688851161604204,0.013727715596793252,7573]
["High","Q9Y580","RNA-binding protein 7 [OS=Homo sapiens]",6,2,4,2,266,30.5,9.57,11.13,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RBM7","ENSG00000076053","","","",369.7,369.7,390.9,558.4,461.2,491.5,0.7479981470451988,-0.4188933986407789,0.012721579625537242,1.895458959437513,0.06850351290772054,1.1642871570138524,1450]
["High","Q9Y587-1","AP-4 complex subunit sigma-1 [OS=Homo sapiens]",7,1,3,1,144,17,5.19,5.1,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","AP4S1","ENSCANG00000008358; ENSCATG00000035780; ENSG00000100478; ENSGGOG00000003198; ENSMMUG00000003123; ENSPANG00000017427; ENSPCOG00000016646; ENSPPAG00000041450; ENSPTRG00000006239; ENSRROG00000019504","","Lysosome Vesicle Biogenesis","Lysosome",77.7,72.3,68.8,67.1,83.9,66.4,1.0064397424103035,0.009260797765247323,0.9443201434109135,0.024880746225200128,0.970931219351121,0.012811534370343092,7594]
["High","Q9Y592","Centrosomal protein of 83 kDa [OS=Homo sapiens]",2,2,4,2,693,82,6.28,6.88,"","","","","","","","",55.1,44.8,45.3,52.9,53.6,45.4,0.955892034233048,-0.06508041650633278,0.6276571749343802,0.20227750226241006,0.7656221249629185,0.11598552479956505,6401]
["High","Q9Y597","BTB/POZ domain-containing protein KCTD3 [OS=Homo sapiens]",9,6,8,6,815,88.9,7.03,12.51,"cell organization and biogenesis","plasma membrane;other membranes","","KCTD3","ENSG00000136636","","CDC42 GTPase cycle","",234.4,249,249.9,301.3,265.5,252.1,0.895469532299426,-0.15928374849220125,0.13985697438166633,0.8543158713736287,0.2977919978107583,0.526086976675596,3667]
["High","Q9Y5A7","NEDD8 ultimate buster 1 [OS=Homo sapiens]",24,16,25,16,615,70.5,5.96,60.75,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","","NUB1","ENSG00000013374","","","",1488.4,1455.8,1499.4,1196,1184,1180.8,1.2479218153223994,0.31952754944051676,2.930100981080977E-5,4.533117412147416,0.004867708183038355,2.312675465424497,47]
["High","Q9Y5A9-1","YTH domain-containing family protein 2 [OS=Homo sapiens]",18,10,41,7,579,62.3,8.79,79.38,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity","YTHDF2","ENSCSAG00000001018; ENSG00000198492; ENSMFAG00000026128; ENSMMUG00000011391; ENSMNEG00000041161; ENSNLEG00000009856; ENSPTRG00000000439; ENSRBIG00000043898; ENSRROG00000038863","","","",1946.5,2142.7,1967.9,2101.9,2112.3,2144.3,0.9525988833844459,-0.0700592372799755,0.1884306434027851,0.7248484689605814,0.3606045254139574,0.44296882739182597,4080]
["High","Q9Y5B0","RNA polymerase II subunit A C-terminal domain phosphatase [OS=Homo sapiens]",25,19,43,19,961,104.3,5.27,78.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CTDP1","ENSG00000060069","","TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1735.4,1710.8,1813.6,1681.5,1655.2,1709.4,1.0423495372664036,0.05983914625414951,0.10946937784319681,0.960707350172146,0.2547650975259853,0.5938600700185216,3355]
["High","Q9Y5B6","PAX3- and PAX7-binding protein 1 [OS=Homo sapiens]",15,12,23,12,917,104.7,5.68,46.07,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity","PAXBP1","ENSG00000159086; ENSG00000263141","","","",1046.4,1057.1,1040.6,1193.4,1133.5,1173.7,0.8981603153745071,-0.1549551158974856,2.8867270992597384E-3,2.5395942708084442,0.03285650902481055,1.4833785818565606,686]
["High","Q9Y5B8","Nucleoside diphosphate kinase 7 [OS=Homo sapiens]",15,4,8,4,376,42.5,6.47,11.18,"other metabolic processes","cytosol;cytoskeleton","kinase activity;other molecular function","NME7","ENSG00000143156","Pyrimidine metabolism; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",188.6,214.8,203,210.4,220.5,224.9,0.9246721561451662,-0.11298614822196917,0.13157326465068442,0.8808323492802989,0.2873633707391731,0.5415685907587628,3575]
["High","Q9Y5B9","FACT complex subunit SPT16 [OS=Homo sapiens]",44,50,246,50,1047,119.8,5.66,516.81,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","SUPT16H","ENSG00000092201","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation","",12059.3,12250.2,11851.2,11567.9,12787.2,12232.8,0.9883240087569934,-0.016944007332849474,0.7205062661434494,0.14236223783446209,0.831959912163273,0.07989759960557688,6762]
["Medium","Q9Y5E1","Protocadherin beta-9 [OS=Homo sapiens]",1,1,1,1,797,87,5.02,2.2,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;other cell component","other molecular function","PCDHB9","ENSG00000177839","","","",72.5,92.9,68,79.9,97.1,85.3,0.8898208158597025,-0.1684132465576363,0.35374959857071375,0.4513040442976825,0.5392574903631653,0.2682038137714581,5122]
["Low","Q9Y5F9-1","Protocadherin gamma-B6 [OS=Homo sapiens]",1,1,1,1,930,101,5.26,0,"cell adhesion","plasma membrane;other membranes","other molecular function","PCDHGB6","ENSG00000253305","","","",103.6,103.7,100.4,91.1,89.9,101.3,1.089975203684024,0.12429531488385172,0.08837415201114641,1.0536747404215983,0.22208734435244004,0.6534761890179372,3107]
["High","Q9Y5J1","U3 small nucleolar RNA-associated protein 18 homolog [OS=Homo sapiens]",25,11,31,11,556,62,8.76,68.25,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","UTP18","ENSG00000011260","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1276.4,1269.7,1391.2,1768.2,1663.6,1761.5,0.7581499239404618,-0.39944492572857687,1.2862785221524286E-3,2.890664982005157,0.023912530240395625,1.6213744677444222,420]
["High","Q9Y5K3","Choline-phosphate cytidylyltransferase B [OS=Homo sapiens]",26,8,15,5,369,41.9,6.4,29.65,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PCYT1B","ENSG00000102230","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways","Synthesis of PC","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer",217.6,205.2,226,263.8,235.4,233.1,0.8859756930219854,-0.17466097628503724,0.07397174466817014,1.130934138080253,0.19759540963704156,0.7042231487790538,2923]
["High","Q9Y5K5-1","Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",58,14,68,1,329,37.6,5.33,154.39,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UCHL5","ENSCANG00000036448; ENSCATG00000035323; ENSG00000116750; ENSGGOG00000004347; ENSMFAG00000038349; ENSMLEG00000030039; ENSMNEG00000039813; ENSPPAG00000029294; ENSPTRG00000001793","TGF-beta signaling pathway","UCH proteinases; Downregulation of TGF-beta receptor signaling","",28.5,25.3,28.1,27.8,24.5,24.5,1.0664062500000002,0.09275714091985275,0.31787306920650416,0.4977462647572732,0.5048724418967422,0.2968183343130542,4916]
["High","Q9Y5K5-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",58,14,68,1,328,37.5,5.4,158.34,"","","","UCHL5","","","","",2665.7,2815.2,2729,2561.5,2820.3,2630,1.024726029107067,0.03523824213873748,0.4980336065466828,0.30274135072353486,0.6686118294216815,0.17482594391588088,5816]
["High","Q9Y5K6","CD2-associated protein [OS=Homo sapiens]",40,21,42,21,639,71.4,6.4,76.66,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CD2AP","ENSG00000198087","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis","Nephrin family interactions","Bacterial invasion of epithelial cells",1938.5,1967.2,1978.3,2280.5,2116.2,2175.8,0.8952453404336248,-0.1596449902505783,9.73564839048509E-3,2.011635119333204,0.0603301132007203,1.219465859792131,1260]
["High","Q9Y5K8","V-type proton ATPase subunit D [OS=Homo sapiens]",47,12,31,12,247,28.2,9.36,54.53,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol","transporter activity","ATP6V1D","ENSG00000100554","Proximal tubule transport","Amino acids regulate mTORC1; Neutrophil degranulation; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",807.1,855.6,805.2,727.5,756.9,763.2,1.0980156611496705,0.1348986318493329,0.020761281393867594,1.6827458451823598,0.09035902180786967,1.0440284792317978,1794]
["High","Q9Y5L0-2","transportin-3 [OS=Homo sapiens]",34,23,66,23,923,104.1,5.57,160,"transport","other membranes;nucleus;other cell component","other molecular function","TNPO3","ENSCANG00000033070; ENSCATG00000030018; ENSG00000064419; ENSGGOG00000008339; ENSMLEG00000037881; ENSMMUG00000004311; ENSMNEG00000045277; ENSPPAG00000034975; ENSPPYG00000017990; ENSPTRG00000019676","","","Nucleocytoplasmic transport",2417.2,2439.3,2402.8,2543.6,2540.7,2587.5,0.9462316535884671,-0.07973467181914438,1.7461070971463563E-3,2.757929122444156,0.027212782863310876,1.5652270436527662,501]
["High","Q9Y5M8","signal recognition particle receptor subunit beta [OS=Homo sapiens]",30,7,22,7,271,29.7,9.04,48.58,"transport","other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SRPRB","ENSG00000144867","","SRP-dependent cotranslational protein targeting to membrane; XBP1(S) activates chaperone genes","Protein export",935.3,970,941.8,908.9,1032.3,994.4,0.9698528409865105,-0.04416223592273768,0.4810965352742735,0.3177677707563063,0.6551101756926277,0.18368565470813658,5734]
["Low","Q9Y5N1","histamine H3 receptor [OS=Homo sapiens]",2,1,1,1,445,48.6,9.29,2.08,"cell-cell signaling;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","HRH3","ENSG00000101180","GPCRs, class A rhodopsin-like; Monoamine transport","Histamine receptors","Neuroactive ligand-receptor interaction",89.1,94.5,103.9,90.6,84.3,108.4,1.0148252735615955,0.02123135434100136,0.8759024889756948,0.05754423955902533,0.9283353649955511,0.032295104755274036,7367]
["High","Q9Y5N5","HemK methyltransferase family member 2 [OS=Homo sapiens]",24,5,9,5,214,22.9,5.11,15.88,"protein metabolism;DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","N6AMT1","ENSG00000156239","","Eukaryotic Translation Termination; Methylation","",465.1,472.1,429.4,427.1,470.6,431,1.0285241213215923,0.040575628868165306,0.5461110220319116,0.26271905811134777,0.7046826739423511,0.1520064063851402,6051]
["High","Q9Y5N6","Origin recognition complex subunit 6 [OS=Homo sapiens]",41,8,12,8,252,28.1,8.66,17.75,"DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC6","ENSG00000091651","Cell cycle; G1 to S cell cycle control; DNA replication","Assembly of the ORC complex at the origin of replication; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDT1 association with the CDC6:ORC:origin complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle",638.8,620.7,634.4,528.6,532.4,510.3,1.2053077069942089,0.2694015038692845,2.4977099379228904E-4,3.602457998177206,0.012830341575856531,1.8917617814633432,152]
["High","Q9Y5P4-1","Collagen type IV alpha-3-binding protein [OS=Homo sapiens]",24,14,39,14,624,70.8,5.48,67.26,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus","transporter activity;kinase activity;other molecular function","CERT1","ENSG00000113163; ENSPTRG00000016996","Sphingolipid pathway","","",1310.7,1269.1,1270.9,1320.5,1208.4,1291.2,1.0080102615114788,0.011510325500893802,0.7921435347117378,0.10119611805025001,0.8804351201465123,0.055302641968732136,7025]
["High","Q9Y5P6","Mannose-1-phosphate guanyltransferase beta [OS=Homo sapiens]",20,5,17,5,360,39.8,6.61,37.01,"other metabolic processes","other cell component","other molecular function","GMPPB","ENSG00000173540","","Synthesis of GDP-mannose","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",399.5,325.6,357.5,353.3,330.4,344.5,1.0529079945535886,0.07437937596431497,0.46388995236036573,0.3335850339949419,0.6407310716486353,0.1933242147964252,5653]
["High","Q9Y5Q0","fatty acid desaturase 3 [OS=Homo sapiens]",16,5,7,4,445,51.1,7.77,15.7,"other metabolic processes","other membranes;ER/Golgi","other molecular function","FADS3","ENSG00000221968","","","",115.4,119.7,113.9,146.8,142.1,137.4,0.8186722965048088,-0.28864201886692203,1.3264893309072015E-3,2.8772962387436674,0.0242558049080174,1.6151843091100557,427]
["High","Q9Y5Q8-1","general transcription factor 3C polypeptide 5 [OS=Homo sapiens]",30,13,22,13,519,59.5,6.9,44.41,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity","GTF3C5","ENSG00000148308","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",958.9,947.5,966.8,1020.8,1073.9,1013,0.9245422659844902,-0.11318882011197089,0.017235396350822513,1.7635787249629737,0.08160944494070478,1.0882595759488571,1649]
["High","Q9Y5Q9","General transcription factor 3C polypeptide 3 [OS=Homo sapiens]",24,14,47,14,886,101.2,5.07,80.98,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","nucleic acid binding activity","GTF3C3","ENSG00000119041","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1353.1,1463,1356.1,1504,1574.9,1528.6,0.9055236028214868,-0.14317584881990242,0.025348352298584488,1.5960502655570554,0.10186306471814087,0.9919832614982026,1943]
["Medium","Q9Y5R2","Matrix metalloproteinase-24 [OS=Homo sapiens]",2,1,1,1,645,73.2,9.23,0,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","MMP24","ENSG00000125966","Matrix metalloproteinases","Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action",35.9,57.8,30.7,29,51.9,42,1.0122050447518305,0.017501569757940504,0.9647260473337599,0.015595995487753166,0.9811880913875208,0.008247731435965655,7677]
["High","Q9Y5S2","Serine/threonine-protein kinase MRCK beta [OS=Homo sapiens]",16,25,42,23,1711,194.2,6.37,97.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPB","ENSG00000198752","VEGFA-VEGFR2 signaling pathway","CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle","",1954,1899.4,1860.3,1840.5,1934.7,1872.1,1.0117578311759603,0.016864015753072233,0.5987781796483208,0.2227340343660483,0.7444681571168932,0.12815387344460902,6280]
["High","Q9Y5S9","RNA-binding protein 8A [OS=Homo sapiens]",48,8,62,2,174,19.9,5.72,123.74,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","RBM8A","ENSG00000265241","","mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",1578.6,1550.7,1606.4,2680.6,1785.4,1554.8,0.7865566037735849,-0.34637750337861417,0.2806756489504579,0.5517952645482855,0.46558645995436054,0.3319996581962492,4707]
["High","Q9Y5S9-2","Isoform 2 of RNA-binding protein 8A [OS=Homo sapiens]",47,7,53,1,173,19.7,5.92,108.93,"","","","RBM8A","","","","",133.1,126.4,110.8,202.2,142.5,124.9,0.7885434412265758,-0.34273785893842235,0.24492289011145602,0.6109706244933196,0.4278205650984896,0.36873834296662067,4470]
["High","Q9Y5T5-1","ubiquitin carboxyl-terminal hydrolase 16 [OS=Homo sapiens]",12,6,11,6,823,93.5,6.93,26.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","USP16","ENSG00000156256","","Ub-specific processing proteases","",179,173.5,189.8,199.1,200.8,192.6,0.9152742616033754,-0.12772398365777515,0.0362728063579046,1.4404188425832427,0.12626753100424393,0.8987083115075751,2243]
["High","Q9Y5U2-1","Protein TSSC4 [OS=Homo sapiens]",7,3,5,3,329,34.3,5.19,2.98,"","","","TSSC4","ENSG00000184281","","","",53.8,44.8,70.4,59.9,57.3,52.9,0.9935332157554381,-0.009359894493838212,0.9646292042859335,0.015639593888080654,0.9812174084242533,0.008234755292879184,7676]
["High","Q9Y5U9","immediate early response 3-interacting protein 1 [OS=Homo sapiens]",24,1,4,1,82,9,8.22,14.62,"transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","","IER3IP1","ENSG00000134049","","","",186.7,192.6,198.8,186.7,197.1,190.4,1.0067920585161965,0.00976574180969553,0.7929445079802652,0.100757204512437,0.8810745294307543,0.0549873533910204,7027]
["High","Q9Y5V3","Melanoma-associated antigen D1 [OS=Homo sapiens]",15,10,29,7,778,86.1,5.83,61.46,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","MAGED1","ENSG00000179222","","NRAGE signals death through JNK; Caspase activation via Dependence Receptors in the absence of ligand","Neurotrophin signaling pathway",681.1,728.3,724,725.7,748.1,750.2,0.9592625899280575,-0.06000230015433754,0.15003676056245877,0.8238023212544284,0.31082171039312234,0.5074886540453979,3769]
["High","Q9Y5W7","Sorting nexin-14 [OS=Homo sapiens]",3,4,4,4,946,110.1,6.7,1.82,"cell organization and biogenesis;other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX14","ENSG00000135317","","","",107.7,115.5,116.4,128.2,137.6,114.3,0.8934490923441201,-0.162542566308927,0.1384968649018969,0.858560057438643,0.2962694578504139,0.5283131172364823,3650]
["High","Q9Y5W8","Sorting nexin-13 [OS=Homo sapiens]",3,3,3,3,968,112.1,6.58,7.79,"transport;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","SNX13","ENSG00000071189","","","",56.1,51.8,54.4,49.9,48.3,51.4,1.0848930481283423,0.11755282466033486,0.051212431265138435,1.290624605927571,0.1555296240055235,0.8081868779117962,2571]
["High","Q9Y5X1","Sorting nexin-9 [OS=Homo sapiens]",29,10,25,10,595,66.6,5.58,34.17,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","SNX9","ENSG00000130340","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","Salmonella infection",548.2,515.5,573.1,604.6,594.2,658.8,0.8811369509043927,-0.18256182712023794,0.047632066549578925,1.3221005759184055,0.14936191791932218,0.8257601183555063,2490]
["High","Q9Y5X2","Sorting nexin-8 [OS=Homo sapiens]",13,6,12,6,465,52.5,7.39,32.15,"transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX8","ENSG00000106266","","","",358.6,360,362.7,383,411.7,396.1,0.908045011756802,-0.1391642812601585,0.012114852182442445,1.9166818804733354,0.0671346812210863,1.1730530689240566,1409]
["High","Q9Y5X3","sorting nexin-5 [OS=Homo sapiens]",38,14,50,13,404,46.8,6.76,106.93,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","SNX5","ENSG00000089006","","Golgi Associated Vesicle Biogenesis","Endocytosis",1913.8,1970.2,1978.8,1809.2,1862.5,1835.6,1.064550687269624,0.09024464357281509,0.009735791225955444,2.0116287476772996,0.06028315455373522,1.2198040295917458,1261]
["High","Q9Y5Y0","Feline leukemia virus subgroup C receptor-related protein 1 [OS=Homo sapiens]",17,6,22,6,555,59.8,5.97,57.32,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion","transporter activity;other molecular function","FLVCR1","ENSG00000162769","","","",563.7,586.7,593.4,687.3,662.2,697.7,0.8517975771785855,-0.2314174685415053,1.8720241729690721E-3,2.727688547628203,0.02849271879637917,1.5452661080813836,513]
["High","Q9Y5Y2","Cytosolic Fe-S cluster assembly factor NUBP2 [OS=Homo sapiens]",24,5,9,5,271,28.8,5.83,21.95,"cell organization and biogenesis;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NUBP2","ENSG00000095906","","Cytosolic iron-sulfur cluster assembly","",408.3,493.6,427.2,325.1,319.8,366.9,1.3135995255979442,0.3935255112039821,0.023937155905863212,1.6209274515806258,0.09811092562361153,1.0082826269336285,1905]
["High","Q9Y5Z4-1","Heme-binding protein 2 [OS=Homo sapiens]",10,2,2,2,205,22.9,4.63,3.08,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","HEBP2","ENSG00000051620","","Neutrophil degranulation","",128.6,130.1,97.5,107.3,117.3,112.7,1.0560332048621406,0.0786551980834924,0.5978520920691066,0.22340624668628595,0.7439090254781808,0.12848017218072627,6275]
["Medium","Q9Y5Z6","Beta-1,3-galactosyltransferase 1 [OS=Homo sapiens]",3,1,1,1,326,38,9.29,2.12,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B3GALT1","ENSG00000172318","Ganglio sphingolipid metabolism; Metabolism of spingolipids in ER and Golgi apparatus","Lewis blood group biosynthesis","Glycosphingolipid biosynthesis; Metabolic pathways",29.5,36.5,24.1,18.2,27.2,22,1.336795252225519,0.4187785146316799,0.1633425799631493,0.7869005890994789,0.32938503728106144,0.4822961330771995,3872]
["High","Q9Y5Z9-1","UbiA prenyltransferase domain-containing protein 1 [OS=Homo sapiens]",6,1,1,1,338,36.8,8.15,3.75,"other metabolic processes;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","UBIAD1","ENSG00000120942; ENSGGOG00000001270","7q11.23 copy number variation syndrome","Metabolism of vitamin K","",23.9,22.6,22.5,27.2,29.2,24.8,0.8497536945812808,-0.2348833655196448,0.03941458769796668,1.4043430120779965,0.133109472640884,0.8757910371678527,2312]
["High","Q9Y605","MORF4 family-associated protein 1 [OS=Homo sapiens]",19,1,2,1,127,14.6,4.7,9.33,"","nucleus;other cell component","","MRFAP1","ENSG00000179010","","","",41.2,37.5,40.1,35.1,28.3,30.3,1.2678762006403415,0.3424138831415789,0.021905683614926466,1.6594431891620118,0.09326040221665532,1.0303027158373785,1834]
["High","Q9Y606","tRNA pseudouridine synthase A [OS=Homo sapiens]",52,20,47,20,427,47.4,8.41,88.3,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","PUS1","ENSG00000177192","","","",1689.7,1703.2,1833.9,1641,1708,1671.4,1.0411122619711577,0.05812564121829476,0.24001378535385012,0.6197638135751691,0.42179330093244694,0.37490032215740454,4443]
["High","Q9Y608","Leucine-rich repeat flightless-interacting protein 2 [OS=Homo sapiens]",4,3,9,1,721,82.1,6.95,14.51,"cell-cell signaling;signal transduction;other biological processes","","other molecular function","LRRFIP2","ENSG00000093167","VEGFA-VEGFR2 signaling pathway","","",59.3,51.2,58.9,61.3,55.7,46.2,1.0379901960784315,0.05379281736070315,0.707935957260005,0.15000602856249703,0.8234118805729359,0.0843828710887821,6713]
["High","Q9Y613","FH1/FH2 domain-containing protein 1 [OS=Homo sapiens]",28,19,40,19,1164,126.5,6.39,72.26,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FHOD1","ENSG00000135723","VEGFA-VEGFR2 signaling pathway","","Salmonella infection",578.9,547.5,558.7,597.5,559.5,549.2,0.9876333372406518,-0.017952559884965715,0.70553787879657,0.1514796649560878,0.8218468980521586,0.08520907969117862,6703]
["High","Q9Y617-1","phosphoserine aminotransferase [OS=Homo sapiens]",68,22,169,21,370,40.4,7.66,380.51,"other metabolic processes","cytosol;other cell component","other molecular function","PSAT1","ENSG00000135069; ENSGGOG00000015480; ENSPPAG00000036829; ENSPTRG00000021045","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Vitamin B6 metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors",8214.9,8892.9,8493.7,8565.1,9706.1,9361,0.9265096517830648,-0.11012208948529689,0.15842161868635846,0.8001855535827291,0.3225439370803356,0.4914111172090935,3835]
["High","Q9Y618-1","Nuclear receptor corepressor 2 [OS=Homo sapiens]",6,14,22,13,2525,274.6,7.59,28.1,"","","","","","","","",926.4,1005.2,950.6,1058.1,993.8,996.3,0.9455416311265664,-0.08078711508607991,0.1527245555792,0.8160911299692833,0.3143050421619382,0.5026486518632918,3794]
["High","Q9Y619","mitochondrial ornithine transporter 1 [OS=Homo sapiens]",5,2,3,2,301,32.7,9.13,6.35,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A15","ENSG00000102743","","Urea cycle","",224.7,247.7,219.7,229.2,238.8,242.1,0.9746514575411911,-0.03704170205163244,0.5599842338169861,0.2518242002485721,0.7152555042766281,0.14553879137971698,6113]
["High","Q9Y620-1","DNA repair and recombination protein RAD54B [OS=Homo sapiens]",2,2,3,2,910,102.9,8.12,4.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RAD54B","ENSG00000197275","Homologous recombination; DNA repair pathways, full network","","Homologous recombination",79.6,77.4,89.6,65.4,68,64.1,1.248607594936709,0.32032014645101164,0.014036180828630637,1.852751045388907,0.07219664025688274,1.141483012289733,1518]
["High","Q9Y624","Junctional adhesion molecule A [OS=Homo sapiens]",51,12,53,12,299,32.6,7.9,98.69,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","F11R","ENSG00000158769","1q21.1 copy number variation syndrome","Integrin cell surface interactions; Tight junction interactions; Cell surface interactions at the vascular wall; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Epithelial cell signaling in Helicobacter pylori infection",2194.9,2228.1,2259.4,2514.6,2428,2476.9,0.9006536828627266,-0.15095562376803967,1.4104795926205304E-3,2.850633193008373,0.024916345382762675,1.6035156576988294,442]
["High","Q9Y625","Glypican-6 [OS=Homo sapiens]",9,3,3,2,555,62.7,5.41,9.71,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC6","ENSG00000183098","miR-509-3p alteration of YAP1/ECM axis","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","",10.9,15.9,11.6,16.3,14.6,12.4,0.8868360277136259,-0.17326071400556867,0.4446490152878699,0.3519826651284094,0.6248775218444362,0.204205097535352,5556]
["High","Q9Y639-1","Isoform 1 of Neuroplastin [OS=Homo sapiens]",33,8,26,8,282,31.3,6.87,63.74,"","","","NPTN","","","","",1335.3,1209.5,1215.9,1379,1220,1300.5,0.9644056930375691,-0.05228792746742699,0.493615897547574,0.30661086172601754,0.6643945747373656,0.17757392253497914,5801]
["Medium","Q9Y646","Carboxypeptidase Q [OS=Homo sapiens]",1,1,1,1,472,51.9,6.18,2.19,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CPQ","ENSG00000104324","","","",32.4,33.7,29.1,38.3,33.6,44.3,{"$f":"AVERAGE(T7746:V7746)/AVERAGE(W7746:Y7746)","v":0.8192771084337348},{"$f":"LOG(Z7746,2)","v":-0.2875765900965856},{"$f":"TTEST(T7746:V7746,W7746:Y7746,2,2)","v":0.1075238162873508},{"$f":"-LOG10(AB7746)","v":0.9684953298266621},{"$f":"AB7746*7808/AF7746","v":0.2521159031746652},{"$f":"-LOG10(AD7746)","v":0.5983997586743465},3330]
["High","Q9Y657","Spindlin-1 [OS=Homo sapiens]",47,10,30,9,262,29.6,6.96,54.87,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes","other membranes;cytosol;nucleus","other molecular function","SPIN1","ENSG00000106723","","","",850.7,892.1,892.5,998.3,1032.7,1008.6,0.8669890775101988,-0.20591427666646875,1.4361235254447071E-3,2.8428082034699043,0.024973836273212188,1.602514739814592,449]
["High","Q9Y664","KICSTOR complex protein kaptin [OS=Homo sapiens]",11,4,6,4,436,48.1,5.26,6.99,"cell organization and biogenesis;stress response;other biological processes","other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity","KPTN","ENSG00000118162","","Amino acids regulate mTORC1","",83.6,67.9,85.9,59.1,76.4,80.7,1.0980573543015728,0.1349534119072567,0.4618643559088623,0.3354855528636699,0.6391770455399499,0.19437883002438192,5642]
["High","Q9Y666","Solute carrier family 12 member 7 [OS=Homo sapiens]",14,11,16,11,1083,119,6.71,33.91,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC12A7","ENSG00000113504","","Cation-coupled Chloride cotransporters","Collecting duct acid secretion",488.5,412.2,473.8,511.7,480.6,491.9,0.9260881282845979,-0.11077860530097333,0.21853828035104286,0.6604724786520014,0.3971019066746434,0.40109802767726926,4297]
["High","Q9Y672","Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",6,3,9,3,507,58.1,8.46,18.36,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG6","ENSG00000088035","GPCRs, other","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG6 causes CDG-1c","N-Glycan biosynthesis; Metabolic pathways",406.6,403.3,392.1,391.7,400.8,428.1,0.984761592659348,-0.022153599474842713,0.626622249894309,0.20299418839659913,0.7650768611688452,0.11629493255263645,6395]
["High","Q9Y673","dolichyl-phosphate beta-glucosyltransferase [OS=Homo sapiens]",17,4,5,4,324,36.9,9.28,10.28,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ALG5","ENSG00000120697","","Synthesis of dolichyl-phosphate-glucose","N-Glycan biosynthesis; Metabolic pathways",128.6,132.4,130.5,129.2,128.2,124.9,1.0240648705205337,0.03430710734375448,0.14563141668299454,0.8367449257080344,0.305259087640489,0.5153313981337105,3725]
["High","Q9Y676","28S ribosomal protein S18b, mitochondrial [OS=Homo sapiens]",7,1,1,1,258,29.4,9.38,3.86,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPS18B","ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Viral carcinogenesis",22,29.6,29.4,39.2,24,23.9,0.9299655568312285,-0.10475081082687748,0.7378007242570772,0.13206092278677334,0.8449322462597916,0.07317811502101029,6818]
["High","Q9Y678","Coatomer subunit gamma-1 [OS=Homo sapiens]",57,37,115,33,874,97.7,5.47,252.96,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","COPG1","ENSG00000181789","VEGFA-VEGFR2 signaling pathway","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",3858.6,4101.2,3895.7,3756.8,4107.5,3986.9,1.0003628324557852,0.00052336164408009,0.9915735962062138,3.6750462190752358E-3,0.996038420066656,0.00172390926592709,7773]
["High","Q9Y679-1","Ancient ubiquitous protein 1 [OS=Homo sapiens]",11,6,16,6,476,53,8.09,37.45,"","","","","","","","",631.5,685.4,695,734.7,740.9,681.9,0.9325144843568945,-0.100801960567666,0.14916364708389682,0.8263370065855506,0.3095879203697678,0.5092159931412753,3762]
["High","Q9Y692-1","Glucocorticoid modulatory element-binding protein 1 [OS=Homo sapiens]",17,8,12,7,573,62.6,4.83,30.46,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GMEB1","ENSG00000162419; ENSGGOG00000009221; ENSPPAG00000038756","","","",550.9,511.8,582.7,760.2,691.1,769.5,0.7409041786743515,-0.4326411244079506,3.9528493652846546E-3,2.4030897353843623,0.038340183657319976,1.4163458110935956,805]
["High","Q9Y696","Chloride intracellular channel protein 4 [OS=Homo sapiens]",74,15,177,14,253,28.8,5.59,365.42,"transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","transporter activity","CLIC4","ENSG00000169504","","","",6270.5,5898.5,6224.1,6314.1,5928.9,5654.4,1.0276967604233016,0.03941463537762815,0.5021752344843865,0.2991447089707277,0.6711715561201796,0.17316645694962324,5842]
["High","Q9Y697","Cysteine desulfurase, mitochondrial [OS=Homo sapiens]",32,10,16,10,457,50.2,8.31,38.46,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","NFS1","ENSG00000244005","","","Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system",429.8,431.3,448,447.5,415.2,444.5,1.001453488372093,2.0954180021932447E-3,0.959904218577571,0.017772099688035132,0.9784506708425164,0.009461064662003624,7660]
["Low","Q9Y6A1","Protein O-mannosyl-transferase 1 [OS=Homo sapiens]",1,1,1,1,747,84.8,8.4,1.87,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","POMT1","ENSG00000130714","","O-linked glycosylation; Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2; Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1","Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Metabolic pathways",23.2,25.2,17,22.4,22.7,17.9,1.0380952380952384,0.053938807110804156,0.7974058668335543,0.09832057338385039,0.8840188851677399,0.05353845711754627,7043]
["High","Q9Y6A4","Cilia- and flagella-associated protein 20 [OS=Homo sapiens]",54,8,19,8,193,22.8,9.76,32.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","","CFAP20","ENSG00000070761","","","",680.1,789.7,712.3,596,825.6,675.5,1.0405321634638312,0.05732156031842009,0.7239579463428343,0.14028666060077521,0.8343414974235942,0.07865615548858311,6775]
["High","Q9Y6A5","Transforming acidic coiled-coil-containing protein 3 [OS=Homo sapiens]",48,33,102,33,838,90.3,5.05,203.73,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","","TACC3","ENSG00000013810","","Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus","",4747,4565,4817.1,3591.5,2988.7,3141.8,1.4533120757045876,0.5393445321022399,1.6911078951698762E-3,2.771828682891876,0.02705772632271802,1.5677087002359515,488]
["High","Q9Y6A9","Signal peptidase complex subunit 1 [OS=Homo sapiens]",17,2,5,2,102,11.8,9.31,8.44,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","translation activity;other molecular function","SPCS1","ENSG00000114902","","","Protein export",311.7,338.4,307.8,295.5,299,283.6,1.0908780321147933,0.12548980716134303,0.06754162811421303,1.170428474756332,0.18608505021728136,0.7302885160091384,2834]
["High","Q9Y6B6","GTP-binding protein SAR1b [OS=Homo sapiens]",31,6,24,2,198,22.4,6.11,44.54,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SAR1B","ENSG00000152700","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Chylomicron assembly","Protein processing in endoplasmic reticulum; Legionellosis",154.9,151.8,146.4,120.6,125.7,116.2,1.2499310344827586,0.3218484957237299,1.2286065033363875E-3,2.910587190175798,0.023397462385489055,1.630831242236898,410]
["High","Q9Y6B7","AP-4 complex subunit beta-1 [OS=Homo sapiens]",5,2,3,2,739,83.2,5.86,0,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","AP4B1","ENSG00000134262","","Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis","Lysosome",39.8,40.6,40.9,35.5,46,33.9,1.0511265164644714,0.0719363264750278,0.6328661416929563,0.19868813843708721,0.768853093875619,0.11415663368885179,6427]
["High","Q9Y6C9","Mitochondrial carrier homolog 2 [OS=Homo sapiens]",23,7,23,7,303,33.3,7.97,72.58,"other biological processes","other membranes;mitochondrion","","MTCH2","ENSG00000109919; ENSG00000285121","","","",1406.4,1612.4,1504.1,1456.3,1567.1,1589.3,0.9805320094521647,-0.028363366944062864,0.7002146513862557,0.1547688062393205,0.8180870863420446,0.08720046270437842,6683]
["High","Q9Y6D0","selenoprotein K [OS=Homo sapiens]",10,1,2,1,94,10.6,10.86,2.47,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","SELENOK","ENSG00000113811","Selenium micronutrient network","","",138.7,103.1,133.5,66.2,69.5,64.6,1.8736894658012977,0.905881869074268,0.006469290394108504,2.1891433537708904,0.048993423275653925,1.3098622143957714,1031]
["High","Q9Y6D5","Brefeldin A-inhibited guanine nucleotide-exchange protein 2 [OS=Homo sapiens]",16,27,51,17,1785,201.9,6.33,82.37,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARFGEF2","ENSG00000124198","","Association of TriC/CCT with target proteins during biosynthesis","Endocytosis",847.8,774.8,776.2,844.8,866,873.1,0.9283641007778939,-0.1072373591837103,0.07323137029085096,1.13530283935506,0.19635664121942456,0.7069544053374242,2912]
["High","Q9Y6D6","Brefeldin A-inhibited guanine nucleotide-exchange protein 1 [OS=Homo sapiens]",29,38,88,28,1849,208.6,5.85,167.77,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","ARFGEF1","ENSG00000066777","","","Endocytosis",3487.8,3637.6,3525.3,4155.9,4418.1,4217.3,0.8326518805750784,-0.26421464268290495,1.4331670585656174E-3,2.8437031826770074,0.024978054449286472,1.6024413920165161,448]
["High","Q9Y6D9","mitotic spindle assembly checkpoint protein MAD1 [OS=Homo sapiens]",40,31,76,31,718,83,5.92,179.87,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD1L1","ENSG00000002822","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; CCL18 signaling pathway","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Viral carcinogenesis",3341.4,3102.2,3235.4,2919.3,2905.5,2905,1.1087310133107289,0.14890939901383143,0.010324534805333317,1.9861295073256213,0.06186797218729282,1.2085341183795706,1303]
["High","Q9Y6E0","Serine/threonine-protein kinase 24 [OS=Homo sapiens]",38,13,53,8,443,49.3,5.69,111.9,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","STK24","ENSG00000102572","","Apoptotic cleavage of cellular proteins","",1161.7,1110.5,1111.3,1252.4,1170.4,1198.4,0.9343587760963215,-0.09795147096199375,0.054510256928427446,1.2635217709656015,0.16097431395505352,0.7932434171205687,2644]
["High","Q9Y6E2","Basic leucine zipper and W2 domain-containing protein 2 [OS=Homo sapiens]",48,20,81,16,419,48.1,6.68,148.74,"developmental processes;other biological processes","other cell component","","BZW2","ENSG00000136261","","","",2347,2425.6,2417,2277.8,2426.4,2377.9,1.0151791135397692,0.021734292354527816,0.5158521432256603,0.28747476074284584,0.6811725916296222,0.16674283508331608,5913]
["High","Q9Y6G5","COMM domain-containing protein 10 [OS=Homo sapiens]",12,2,3,2,202,23,6.54,2.65,"","nucleus;other cell component","","COMMD10","ENSG00000145781","","Neddylation","",25.3,26.6,31.1,27.2,23.8,23,1.1216216216216217,0.1655860657179751,0.2405131144155471,0.6188612379470168,0.4222906222974121,0.37438856273731597,4447]
["High","Q9Y6G9","Cytoplasmic dynein 1 light intermediate chain 1 [OS=Homo sapiens]",59,24,78,24,523,56.5,6.42,187.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","DYNC1LI1","ENSG00000144635","Ciliary landscape; Intraflagellar transport proteins binding to dynein","Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MHC class II antigen presentation; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection",3531.3,3552.1,3530.5,3394.5,3507.3,3516.2,1.0188039930888846,0.026876519218504792,0.1762091666592681,0.7539715027004389,0.3459495029609166,0.4609872890277839,3977]
["High","Q9Y6H1","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 [OS=Homo sapiens]",34,3,6,3,151,15.5,9.22,12.94,"cell organization and biogenesis;stress response;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","CHCHD2","ENSG00000106153","","Mitochondrial protein import","",204.4,189,195.9,244.9,210,214.9,0.8798148701104807,-0.18472810985510904,0.08503752615817962,1.070389382439122,0.2165600144302239,0.6644217282988429,3066]
["High","Q9Y6I3","epsin-1 [OS=Homo sapiens]",18,8,17,1,576,60.3,4.83,58.15,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","EPN1","ENSG00000063245","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway","Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation","Endocytosis",177.3,165.3,190,193.3,170.3,159,1.0191350937619594,0.027345303890593437,0.8006965569879766,0.09653203896421464,0.885906010622378,0.05261235173971315,7057]
["High","Q9Y6I3-1","Isoform 2 of Epsin-1 [OS=Homo sapiens]",16,8,17,1,662,69,5.05,58.01,"","","","EPN1","","","","",697.1,670.3,666.3,635.2,573,563.9,1.1476214660572204,0.19864685882801847,0.02330307826170137,1.6325867062800488,0.09647424977060674,1.015588590022723,1886]
["High","Q9Y6I4-1","Ubiquitin carboxyl-terminal hydrolase 3 [OS=Homo sapiens]",21,8,11,8,520,58.9,8.18,20.69,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","USP3","ENSG00000140455","","Ub-specific processing proteases","",470.3,444.6,468.2,522.9,506,536.8,0.8833748483106598,-0.17890233873077205,0.007400733508529212,2.130725233928551,0.052152461403065065,1.2827251896623266,1108]
["High","Q9Y6I9","Testis-expressed protein 264 [OS=Homo sapiens]",15,3,6,3,313,34.2,4.86,12.37,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TEX264","ENSG00000164081","","Platelet degranulation","",217.8,253.4,226.4,274.8,255.9,222,0.9267968646206988,-0.10967493135340249,0.3840008409910738,0.4156678244934517,0.5678557891019516,0.24576194236862853,5280]
["High","Q9Y6J0","Calcineurin-binding protein cabin-1 [OS=Homo sapiens]",7,11,17,11,2220,246.2,6.02,37.06,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity","CABIN1","ENSG00000099991","","Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",843.9,804.6,774.3,679.6,656.9,670,1.2074757039621231,0.2719941603852718,0.002813307612688856,2.5507827786100132,0.032350965890831494,1.4901127482318794,679]
["High","Q9Y6J9","TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L [OS=Homo sapiens]",15,7,13,7,622,67.8,8.97,17.17,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF6L","ENSG00000162227","","HATs acetylate histones","Basal transcription factors",563.8,638.2,558.7,613.2,611.7,637.8,0.9452407795136093,-0.08124622358135372,0.2771625378588511,0.5572654706715454,0.4616222473553561,0.3357132690229442,4688]
["High","Q9Y6K1","DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",44,31,99,4,912,101.8,6.57,170.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT3A","ENSG00000119772","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency","RMTs methylate histone arginines; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer",2960.1,2864.2,2986.8,3055.6,3133.7,3100.2,0.9485009957478873,-0.07627880669100687,0.021561033333994336,1.6663304289909748,0.09224577987497412,1.035053493124833,1825]
["High","Q9Y6K1-2","Isoform 2 of DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",49,28,94,1,723,81.6,6.81,160.75,"","","","DNMT3A","","","","",26.5,29.6,36.4,40.9,45.7,42.9,0.7142857142857143,-0.4854268271702417,0.018960163633824238,1.7221579188460403,0.08612039421343785,1.0648939908744572,1719]
["Medium","Q9Y6K5","2'-5'-oligoadenylate synthase 3 [OS=Homo sapiens]",1,1,1,1,1087,121.1,8.4,2.19,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS3","ENSG00000111331","Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction","Interferon gamma signaling; OAS antiviral response; Interferon alpha/beta signaling","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease",23.1,20.1,22.8,20.3,21.8,25.2,0.9806835066864784,-0.028140480364501362,0.8151018038106415,0.08878814577283672,0.8937389248916568,0.04878932688400019,7121]
["High","Q9Y6K8","Adenylate kinase isoenzyme 5 [OS=Homo sapiens]",8,3,3,3,562,63.3,5.07,8.18,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK5","ENSG00000154027","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors",70.2,71.7,69.6,87.3,68.3,89.5,0.8629130966952264,-0.21271282085952758,0.1728472764220199,0.7623374593047204,0.341755263181345,0.46628478838262916,3949]
["High","Q9Y6K9","NF-kappa-B essential modulator [OS=Homo sapiens]",10,4,4,4,419,48.2,5.71,10.06,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IKBKG","ENSG00000269335","Nucleotide-binding oligomerization domain (NOD) pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","Downstream TCR signaling; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; TICAM1, RIP1-mediated IKK complex recruitment; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Ovarian tumor domain proteases; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Primary immunodeficiency; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",346.1,241.5,362.6,307,220.2,234.6,1.2473090049881859,0.31881891884750385,0.24789544317959325,0.6057314563711321,0.4306045873962768,0.36592134778174434,4495]
["High","Q9Y6M1","Insulin-like growth factor 2 mRNA-binding protein 2 [OS=Homo sapiens]",42,22,106,19,599,66.1,8.46,221.34,"transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP2","ENSG00000073792","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",2973.9,2898.6,2874.6,3260.3,3145.4,3144,0.9159554750411008,-0.12665062483876932,0.005383930589656723,2.2689005477297304,0.044531493690720014,1.3513327373691641,944]
["High","Q9Y6M4-4","Isoform 4 of Casein kinase I isoform gamma-3 [OS=Homo sapiens]",13,4,6,1,424,49,9.11,8.8,"","","","CSNK1G3","","","","",8.2,13.5,8.5,16.2,11.2,11.4,0.7783505154639176,-0.36150810286204854,0.29336385849197694,0.5325933909164408,0.48000524038251385,0.3187540212561095,4772]
["High","Q9Y6M5","zinc transporter 1 [OS=Homo sapiens]",31,10,20,10,507,55.3,6.48,52.13,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A1","ENSG00000170385","Zinc homeostasis","Zinc efflux and compartmentalization by the SLC30 family","Mineral absorption",525.4,559,553.5,489.9,507.5,489.5,1.1015535678256776,0.13953965405589863,0.013674270581414034,1.8640958306922064,0.0712266208803741,1.1473576588818506,1499]
["High","Q9Y6M7-7","Isoform 7 of Sodium bicarbonate cotransporter 3 [OS=Homo sapiens]",12,16,29,16,1259,140.7,6.62,38.28,"","","","SLC4A7","","","","",885.6,971.4,967.9,970,1099.4,1050.4,0.9054747099173023,-0.14325374789901543,0.10463793744373608,0.9803108294711868,0.24765474857856662,0.6061533403578951,3299]
["Medium","Q9Y6N6","Laminin subunit gamma-3 [OS=Homo sapiens]",1,1,1,1,1575,171.1,6.58,0,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes","other molecular function","LAMC3","ENSG00000050555","Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Small cell lung cancer; Malignant pleural mesothelioma","Non-integrin membrane-ECM interactions; Laminin interactions; MET activates PTK2 signaling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer",32.8,36,33,24.7,36.7,29.6,1.1186813186813187,0.1617991109896367,0.37793007156074065,0.4225885502811986,0.561216812237783,0.2508693273929072,5258]
["High","Q9Y6N7","Roundabout homolog 1 [OS=Homo sapiens]",9,12,16,12,1651,180.8,6.04,30.93,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ROBO1","ENSG00000169855","Development of ureteric collection system","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; SLIT2:ROBO1 increases RHOA activity","Axon guidance",594.2,563.5,590.1,580.1,538.4,510.4,1.0729940450610842,0.10164206939855198,0.15183498621803365,0.8186281456293237,0.3128041088101337,0.5047275509387606,3790]
["High","Q9Y6P5","Sestrin-1 [OS=Homo sapiens]",5,2,2,2,492,56.5,6.09,4.43,"other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","SESN1","ENSG00000080546","miRNA regulation of DNA damage response; Mesodermal commitment pathway; Head and neck squamous cell carcinoma; p53 transcriptional gene network; DNA damage response","Amino acids regulate mTORC1","p53 signaling pathway; Longevity regulating pathway",54.8,74.6,71,62.1,61.9,63.1,1.071084981293426,0.09907294995442438,0.5076561696801347,0.2944303313516939,0.6751455242484231,0.17060260707072203,5871]
["High","Q9Y6Q1","Calpain-6 [OS=Homo sapiens]",5,3,3,3,641,74.5,7.05,6.71,"cell organization and biogenesis;protein metabolism;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CAPN6","ENSG00000077274","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",107.1,110.8,111.6,121.4,139.5,135.2,0.831860641252209,-0.26558623600920556,0.01694307930449121,1.7710076563774595,0.08091227107612683,1.091985608715129,1635]
["High","Q9Y6Q2-3","Isoform 3 of Stonin-1 [OS=Homo sapiens]",11,8,10,7,1135,127.2,5.31,16.27,"","","","STON1","","","","",412.4,381.8,353.2,503.6,496.4,487,0.7716207128446537,-0.37403622428781214,3.1048115040057073E-3,2.507964761109016,0.03404826997651202,1.467904950087237,712]
["High","Q9Y6Q3-1","zinc finger protein 37 homolog [OS=Homo sapiens]",15,7,7,6,630,71.2,9.09,11.29,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZFP37","ENSG00000136866","","Generic Transcription Pathway","Herpes simplex virus 1 infection",172.3,196.5,176.3,224.1,222.8,215.8,0.8225441376188322,-0.2818349991211588,0.007766242948919053,2.1097890276807036,0.05323865227845476,1.2737729471011685,1139]
["High","Q9Y6Q9-1","Nuclear receptor coactivator 3 [OS=Homo sapiens]",4,4,4,4,1424,155.2,7.47,2.79,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NCOA3","ENSG00000124151","Androgen receptor signaling pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway","Estrogen-dependent gene expression; MAPK6/MAPK4 signaling; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Endocrine resistance; Estrogen signaling pathway; Thyroid hormone signaling pathway; Pathways in cancer; Breast cancer",164.8,147.6,158.2,113.1,100.5,114.5,1.434318805242304,0.5203657267058774,2.0923011301575505E-3,2.6793758103620076,0.02943547247616244,1.5311289888260482,555]
["High","Q9Y6R0","Numb-like protein [OS=Homo sapiens]",10,5,9,3,609,64.9,8.85,22.59,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction","other cell component","","NUMBL","ENSG00000105245","Notch signaling; Notch signaling pathway","","Notch signaling pathway",110.5,108.4,100.5,104.5,103.1,93.1,1.0621882274692382,0.08703944483722946,0.2559808027660186,0.5917926033030079,0.43908130667774015,0.3574550520313872,4552]
["High","Q9Y6R4-1","Mitogen-activated protein kinase kinase kinase 4 [OS=Homo sapiens]",6,9,15,9,1608,181.6,6.32,20.28,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","kinase activity;other molecular function","MAP3K4","ENSG00000085511","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)","","MAPK signaling pathway; GnRH signaling pathway",655.5,587.6,567.5,436.8,422.2,450.3,1.3828763461391582,0.467672159534374,3.8734876946724776E-3,2.411897819365343,0.038090921813605426,1.4191785171338038,794]
["Medium","Q9Y6V0-1","Protein piccolo [OS=Homo sapiens]",0,1,4,1,5065,552.9,6.51,8.88,"","","","","","","","",65.7,77.4,77.3,76,66.6,85,0.9683655536028123,-0.0463763337354238,0.733777215847949,0.13443577743307156,0.8410646654933626,0.07517061206499955,6812]
["High","Q9Y6V7","Probable ATP-dependent RNA helicase ddx49 [OS=Homo sapiens]",14,4,9,4,483,54.2,9.06,20.08,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX49","ENSG00000105671","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",262.3,288.3,243.4,255.4,298.1,279.8,0.9528381135245411,-0.06969697272951293,0.5060578155881591,0.2957998634832495,0.6742831781761682,0.1711576748427048,5860]
["High","Q9Y6W3","Calpain-7 [OS=Homo sapiens]",18,11,17,11,813,92.6,7.65,31.21,"protein metabolism;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CAPN7","ENSG00000131375","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",510.2,508.1,486,519.5,526,485.8,0.9823679226800758,-0.025664641819668235,0.5726557853680705,0.24210634737723313,0.723744961501116,0.14041444668402953,6178]
["High","Q9Y6W5","Wiskott-Aldrich syndrome protein family member 2 [OS=Homo sapiens]",17,10,22,10,498,54.3,5.53,38.22,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","WASF2","ENSG00000158195","Regulation of actin cytoskeleton","RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs","Adherens junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Choline metabolism in cancer",1022.3,950.3,1015.3,1081.8,1048,977.5,0.9615743571589482,-0.05652967148062648,0.3577805463525691,0.44638327707612674,0.5430696939970566,0.2651444323336571,5144]
["High","Q9Y6X2","E3 SUMO-protein ligase PIAS3 [OS=Homo sapiens]",3,2,2,2,628,68,7.69,5.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","PIAS3","ENSG00000131788","Androgen receptor signaling pathway; Prolactin signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; EGF/EGFR signaling pathway; Regulatory circuits of the STAT3 signaling pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Interferon type I signaling pathways","SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMOylation of immune response proteins; SUMOylation of DNA replication proteins","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway",111,104.8,85.1,46.9,54.5,55,1.9239130434782608,0.9440435940259846,0.004263654124385146,2.3702180333350316,0.039350604495507355,1.4050485917154196,846]
["High","Q9Y6X3-1","MAU2 chromatid cohesion factor homolog [OS=Homo sapiens]",5,2,2,2,613,69,7.25,5.55,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MAU2","ENSANAG00000026794; ENSCANG00000033671; ENSCATG00000015302; ENSCCAG00000031923; ENSCSAG00000005122; ENSG00000129933; ENSGGOG00000002989; ENSMFAG00000041829; ENSMNEG00000034232; ENSPPAG00000032359; ENSPTRG00000010738; ENSRBIG00000036077; ENSRROG00000032649; ENSSBOG00000034577","Cohesin complex - Cornelia de Lange syndrome","Cohesin Loading onto Chromatin","",108.7,84.1,77.7,117.6,90.3,96.8,0.8877584509353463,-0.17176090597230784,0.41448060833238604,0.38249578330729755,0.5961069423207349,0.224675820304342,5429]
["High","Q9Y6X4-1","Soluble lamin-associated protein of 75 kDa [OS=Homo sapiens]",13,6,9,6,670,74.9,4.6,21.39,"","other membranes;nucleus","","FAM169A","ENSG00000198780","","RHOF GTPase cycle","",341.5,349.7,297.8,419.5,423.6,400.4,0.7953357458785686,-0.3303640814577957,8.562039494229616E-3,2.067422773221351,0.05617849106802087,1.2504299299552462,1190]
["High","Q9Y6X5","Bis(5'-adenosyl)-triphosphatase ENPP4 [OS=Homo sapiens]",5,2,2,2,453,51.6,6.15,2.38,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes","other molecular function","ENPP4","ENSG00000001561","","Neutrophil degranulation","Purine metabolism; Metabolic pathways",8,11.3,9.8,12.6,11.3,16.5,0.7202970297029704,-0.4733361398435107,0.1087471287372677,0.9635822009482453,0.2540686957452382,0.5950488418469825,3342]
["High","Q9Y6X8","Zinc fingers and homeoboxes protein 2 [OS=Homo sapiens]",2,2,2,2,837,92.3,6.86,3.13,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZHX2","ENSG00000178764","","","",46.7,45.5,61.8,55.2,62.4,55.6,0.8891454965357969,-0.16950857914446102,0.3274415401587883,0.4848662256041443,0.5144192244587161,0.28868280967884097,4970]
["High","Q9Y6X9-1","MORC family CW-type zinc finger protein 2 [OS=Homo sapiens]",23,18,39,18,1032,117.8,8.38,66.76,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","MORC2","ENSG00000133422","","Fatty acyl-CoA biosynthesis","",1796.3,1791.2,1834.6,1677,1681.6,1743.3,1.0627609322017288,0.08781709948717999,0.013647485078749324,1.8649473718503855,0.07127729999657172,1.1470487598521986,1495]
["High","Q9Y6Y0","influenza virus NS1A-binding protein [OS=Homo sapiens]",10,5,7,5,642,71.7,5.53,11.53,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","IVNS1ABP","ENSG00000116679","","","",263.2,298.3,282.2,522.2,624.7,581.2,0.48822406110757477,-1.034384697791263,7.1593280187089647E-4,3.14512773906956,0.018571439591388572,1.7311544300047679,301]
["High","Q9Y6Y8","SEC23-interacting protein [OS=Homo sapiens]",14,16,38,16,1000,111,5.54,49.87,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC23IP","ENSG00000107651","","COPII-mediated vesicle transport","",1253.2,1169.3,1213.6,1283.9,1198.4,1250.3,0.9741467073889514,-0.037789035019111746,0.40668530894298305,0.39074151571991217,0.5886909329304434,0.2301126531781492,5394]

{"sheet":"L-P","index":2,"n_rows":7809,"n_cols":32,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["Protein FDR Confidence: Combined","Accession","Description","Coverage [%]","# Peptides","# PSMs","# Unique Peptides","# AAs","MW [kDa]","calc. pI","Score Sequest HT: Sequest HT","Biological Process","Cellular Component","Molecular Function","Gene Symbol","Ensembl Gene ID","WikiPathways","Reactome Pathways","KEGG Pathways","Abundances (Normalized): F19: 129C, Sample, Le-P","Abundances (Normalized): F19: 130C, Sample, Le-P","Abundances (Normalized): F19: 131C, Sample, Le-P","Abundances (Normalized): F19: 126, Sample, DMSO","Abundances (Normalized): F19: 127C, Sample, DMSO","Abundances (Normalized): F19: 128C, Sample, DMSO","Ratio","log2(Ratio)","P-Value","− log10(P-Value)","q-Value","− log10(q-Value)","Rank (P-Value)"]
["Medium","A0A0B4J2F0","Protein PIGBOS1 [OS=Homo sapiens]",19,1,1,1,54,6.3,8.5,0,"stress response;other biological processes","other membranes;mitochondrion","","PIGBOS1","ENSG00000225973","","","",49.1,54.9,50.1,51.5,54.7,56.6,{"$f":"AVERAGE(T2:V2)/AVERAGE(W2:Y2)","v":0.9465601965601964},{"$f":"LOG(Z2,2)","v":-0.07923383775146196},{"$f":"TTEST(T2:V2,W2:Y2,2,2)","v":0.28082936556441224},{"$f":"-LOG10(AB2)","v":0.5515574811726816},{"$f":"AB2*7808/AF2","v":0.5276024269314078},{"$f":"-LOG10(AD2)","v":0.27769321539918596},4156]
["High","A0AV96","RNA-binding protein 47 [OS=Homo sapiens]",13,6,11,6,593,64.1,7.68,29.14,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","RBM47","ENSG00000163694","TYROBP causal network in microglia","","",262.1,217.8,257.4,338,389.1,365.5,0.6748123741533956,-0.5674416660661825,0.004364745952509383,2.3600410290796354,0.06955089060651685,1.1576973044495136,490]
["High","A0AVF1","intraflagellar transport protein 56 [OS=Homo sapiens]",10,4,5,4,554,64.1,6.93,8.28,"cell organization and biogenesis;transport;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","TTC26","ENSG00000105948","Ciliary landscape; Genes related to primary cilium development (based on CRISPR)","Intraflagellar transport","",147.2,117.9,142.4,164.5,182.6,155.9,0.8101391650099404,-0.30375834068708707,0.05694546651132894,1.2445408448506123,0.23904849597873998,0.6215139844098932,1860]
["High","A0AVT1-1","Ubiquitin-like modifier-activating enzyme 6 [OS=Homo sapiens]",33,26,66,26,1052,117.9,6.14,133.34,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBA6; UBE1L2","ENSG00000033178","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",2086.5,2156.8,2152.7,2226.3,2165.4,2198.9,0.970473098048736,-0.04323987355028555,0.08737144057435357,1.058630503611407,0.2946851870430033,0.5306416943067436,2315]
["High","A0FGR8-2","Isoform 2 of Extended synaptotagmin-2 [OS=Homo sapiens]",17,12,21,12,893,98.8,8.68,40.11,"","","","ESYT2","","","","",714.6,584.4,645.7,655.7,659.6,616.4,1.0067298234715534,0.00967655858193141,0.9190638559278126,0.03665431308216546,0.955532701342791,0.019754445427698466,7510]
["High","A0JLT2","Mediator of RNA polymerase II transcription subunit 19 [OS=Homo sapiens]",11,1,1,1,244,26.3,9.82,3.66,"other biological processes","nucleus","other molecular function","MED19","ENSG00000156603","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",32.5,53.6,28,28.4,27.5,26.2,1.3897685749086481,0.47484466451087703,0.24913037621174627,0.6035733161533657,0.49711473995944666,0.30354335939541044,3913]
["High","A0JNW5-1","UHRF1-binding protein 1-like [OS=Homo sapiens]",16,14,18,14,1464,164.1,6.32,42.2,"","cytosol;other cytoplasmic organelle","other molecular function","UHRF1BP1L","ENSG00000111647","","RND2 GTPase cycle","",635.8,797.2,574.9,616.9,586.5,595.9,1.1159339743233478,0.15825167077448227,0.3575150479024889,0.4467056739091142,0.5940577769786408,0.22617131427343068,4699]
["High","A0MZ66","Shootin-1 [OS=Homo sapiens]",29,17,34,17,631,71.6,5.33,61.53,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SHTN1","ENSG00000187164","","Recycling pathway of L1","",1205.1,1195.6,1176,1363.7,1291.1,1246.9,0.9167029756260091,-0.12547373839130327,0.03673076491211001,1.4349700274497097,0.193127146420037,0.7141566764443056,1485]
["Medium","A0PJW6","Transmembrane protein 223 [OS=Homo sapiens]",4,1,1,1,202,22,11.02,0,"developmental processes","other membranes","","TMEM223","ENSG00000168569","","","",70.2,95.4,70.6,72.8,60.3,73.5,1.1432720232333011,0.19316871053209783,0.3518614470030513,0.4536283156344753,0.5896832320669294,0.22938122142406092,4659]
["Medium","A0PJZ3","Glucoside xylosyltransferase 2 [OS=Homo sapiens]",2,1,1,1,443,51,9.77,0,"protein metabolism;other metabolic processes","other membranes","other molecular function","GXYLT2","ENSG00000172986","Vitamin D receptor pathway","","Other types of O-glycan biosynthesis",28.8,24.3,35.6,23.5,27.1,26.6,1.148963730569948,0.20033325703298327,0.33152384333477763,0.47948523149345795,0.572432147005295,0.24227598484416346,4522]
["High","A0PK00","Transmembrane protein 120B [OS=Homo sapiens]",9,2,3,2,339,40.2,8.9,8.9,"cell organization and biogenesis;transport;other biological processes","other membranes;nucleus","","TMEM120B","ENSG00000188735","","","",138.3,106.1,135.3,105,131.5,116.9,1.0744199207696663,0.10355795906747253,0.5314563604908582,0.27453239092640724,0.7168096843518088,0.1445961358345753,5789]
["Medium","A1A5C7-1","Solute carrier family 22 member 23 [OS=Homo sapiens]",1,1,1,1,686,73.7,7.74,2.24,"transport","other membranes","transporter activity","SLC22A23","ENSG00000137266","","","",81.8,144,90.5,128.9,96.6,105.7,0.9550120772946861,-0.06640911698193148,0.8301409811042642,0.08084814603803836,0.9053975108900816,0.04316070379723701,7159]
["High","A1L020","RNA-binding protein MEX3A [OS=Homo sapiens]",22,8,18,8,520,54.1,7.27,58.94,"","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MEX3A","ENSG00000254726","","","",514,449.9,540.4,630.8,595.1,607.7,0.8204079406631762,-0.28558663927151734,0.01898669565471004,1.7215506110288363,0.147071547293627,0.8324713384797074,1008]
["High","A1L0T0","Acetolactate synthase-like protein [OS=Homo sapiens]",22,11,18,11,632,67.8,8.15,54.07,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ILVBL","ENSG00000105135","","","",797.4,701.8,762.3,718.7,838.7,802.7,0.9582221092326595,-0.06156799346847823,0.507463307780094,0.29459535401518255,0.7005434064969897,0.15456495014539015,5656]
["High","A1L170","Uncharacterized protein C1orf226 [OS=Homo sapiens]",8,1,1,1,272,29,5.27,3.81,"","","","C1orf226","ENSG00000239887","","","",32.8,53.9,35.5,37.7,32.4,29.6,1.2256770310932799,0.2935788754205336,0.3468742309551284,0.45982796239397444,0.5852191001075288,0.23268150801505094,4628]
["High","A1X283","SH3 and PX domain-containing protein 2B [OS=Homo sapiens]",22,17,37,17,911,101.5,8.69,68.96,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytoskeleton;other cell component","enzyme regulator activity;other molecular function","SH3PXD2B","ENSG00000174705","","","",1886.9,1852,1731.9,1822.6,1692.6,1699.3,1.0491514047367916,0.06922289059499225,0.2476009516213054,0.6062476904956692,0.4962187449330474,0.3043268340436117,3896]
["High","A2AJT9-1","BCLAF1 and THRAP3 family member 3 [OS=Homo sapiens]",9,6,7,6,711,83.8,9.7,7.11,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","BCLAF3","ENSG00000173681","","","",353.7,339.5,319.2,357.1,344.1,359.4,0.954554026023006,-0.06710124103006156,0.22086662391119954,0.6558699072446474,0.4642063524895413,0.33328892068260624,3715]
["High","A2RRP1-1","neuroblastoma-amplified sequence [OS=Homo sapiens]",8,15,28,15,2371,268.4,5.96,49.89,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","NBAS","ENSG00000151779","","COPI-dependent Golgi-to-ER retrograde traffic","",1074.4,1009.8,1139.3,1131.1,1232.1,1154.8,0.9162876634451392,-0.12612749932302142,0.11159813368511685,0.9523430682750769,0.33347042778928143,0.4769426733437671,2613]
["High","A2RTX5","Probable threonine--tRNA ligase 2, cytoplasmic [OS=Homo sapiens]",7,4,5,4,802,92.6,6.05,12.01,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","TARS3","ENSG00000185418","","","Aminoacyl-tRNA biosynthesis",141.8,126.6,127.8,135.7,126.2,131.5,1.00711743772242,0.01023192261095619,0.8757159674409418,0.057636731475068766,0.9306642539511193,0.031206966660809934,7347]
["High","A2RU67","Protein FAM234B [OS=Homo sapiens]",2,1,2,1,622,67,5.02,6.52,"","other membranes;cytoskeleton;ER/Golgi","","FAM234B","ENSG00000084444","","","",64.3,50.7,83.9,84.8,85.6,90.6,0.7620689655172413,-0.39200653062350294,0.10236656614604991,0.9898418647393478,0.3183106923410425,0.49714877279363484,2511]
["Medium","A2RUB1","Meiosis-specific coiled-coil domain-containing protein MEIOC [OS=Homo sapiens]",1,1,1,1,952,107.5,7.12,1.86,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","MEIOC","ENSG00000180336","","","",19.2,9.8,19,34.2,28.7,27.7,0.5298013245033112,-0.9164766444377168,0.018508461885984845,1.7326296710463838,0.14553280000581034,0.8370391148831294,993]
["High","A2RUC4","tRNA wybutosine-synthesizing protein 5 [OS=Homo sapiens]",18,5,6,5,315,36.5,7.55,9.39,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TYW5","ENSG00000162971","","Synthesis of wybutosine at G37 of tRNA(Phe)","",186.8,140.9,176.5,180.7,191.2,169.2,0.931805581223434,-0.10189912312391125,0.46616329099625586,0.3314619288966502,0.6721704480330131,0.17252058519935398,5415]
["High","A2VDJ0","Transmembrane protein 131-like [OS=Homo sapiens]",1,1,1,1,1609,179.2,6.86,2.49,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","TMEM131L","ENSG00000121210","","","",55.4,30.6,51.7,50.6,64.3,55.7,0.8071512309495895,-0.3090890871833264,0.2758715834938457,0.5592930322768964,0.5231977954627028,0.28133409461574704,4117]
["High","A3KMH1","von Willebrand factor A domain-containing protein 8 [OS=Homo sapiens]",12,16,18,16,1905,214.7,7.4,32.67,"","mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","VWA8","ENSG00000102763","","","",505.4,401.2,489.2,498.2,526.8,507.2,0.9109776791541574,-0.13451238945291494,0.24572192951927715,0.6095560830631829,0.49435630654123064,0.3059599211445624,3881]
["High","A3KN83-1","protein strawberry notch homolog 1 [OS=Homo sapiens]",21,17,54,17,1393,154.2,7.88,87.98,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SBNO1","ENSG00000139697","","","",1015,996.8,1079.5,951.9,922.4,922.1,1.105457016163639,0.14464292947510857,0.02186191418075722,1.6603118148590983,0.15447767051887093,0.8111342882215925,1105]
["High","A4D1E9-1","GTP-binding protein 10 [OS=Homo sapiens]",13,5,13,5,387,42.9,9.03,25.82,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","GTPBP10","ENSG00000105793","","","",874,835,864.2,844.2,903.5,917.3,0.9655534709193244,-0.050571939187262174,0.2930449136225751,0.5330658122616119,0.5376162325105889,0.26952762688996823,4256]
["Medium","A4D1F6","Leucine-rich repeat and death domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,860,98,7.46,0,"signal transduction;other biological processes","","","LRRD1","ENSG00000240720","","","",13.7,12,15.6,17.4,16.8,18.8,0.7792452830188679,-0.3598505780311163,0.03111565918264621,1.507020994089654,0.18076716287061134,0.742880458148825,1344]
["High","A4D1P6-1","WD repeat-containing protein 91 [OS=Homo sapiens]",3,1,1,1,747,83.3,6.58,4.28,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle","enzyme regulator activity","WDR91","ENSG00000105875","","CDC42 GTPase cycle","",34.4,34.2,35.1,29,30.9,35.5,1.0870020964360585,0.12035472280771388,0.22871523580769146,0.6407049040123433,0.4735636598213882,0.32462163175932807,3771]
["High","A4D1S0-1","killer cell lectin-like receptor subfamily G member 2 [OS=Homo sapiens]",21,8,17,8,409,42.8,5.87,31.59,"","other membranes","other molecular function","KLRG2","ENSG00000188883","","","",660.4,697.7,713.7,739.8,625.8,634.6,1.0357964203579644,0.05074047773399908,0.581779146906675,0.235241849513275,0.7521993010510546,0.12366707446295651,6039]
["High","A5A3E0","POTE ankyrin domain family member F [OS=Homo sapiens]",11,10,366,1,1075,121.4,6.2,713.12,"","other cell component","","POTEF","ENSG00000196604","","","",34.1,38.3,32.5,28.7,33.4,31.7,1.1183368869936035,0.16135485006189113,0.16922471719689505,0.7715362030095816,0.4068062167097773,0.3906124189200838,3248]
["High","A5LHX3","proteasome subunit beta type-11 [OS=Homo sapiens]",5,1,1,1,300,32.5,6.46,2.96,"protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","other molecular function","PSMB11","ENSG00000222028","","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling","Proteasome",38.1,36.2,30.2,37,30,28.3,1.0965372507869886,0.1329548230583034,0.4389420310586978,0.35759283113297013,0.6538075884216544,0.18455004308491635,5242]
["High","A5PLN9-1","Trafficking protein particle complex subunit 13 [OS=Homo sapiens]",16,4,6,4,417,46.5,5.6,10.22,"","cytosol;ER/Golgi","","C5orf44; TRAPPC13","ENSG00000113597","","RAB GEFs exchange GTP for GDP on RABs","",134.1,104.1,118.2,145.9,151.6,136.6,0.8210089841050449,-0.2845300857309589,0.05589065692793355,1.2526607857410486,0.23678472560678523,0.6256463163014869,1843]
["High","A5YKK6","CCR4-NOT transcription complex subunit 1 [OS=Homo sapiens]",22,46,128,46,2376,266.8,7.11,215.71,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","CNOT1","ENSG00000125107","Ciliary landscape","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",4246.4,3668.8,4399.9,4511.5,4713.7,4706.3,0.8839751641962459,-0.17792225806957768,0.08110784623557231,1.0909371308445055,0.2844968838307945,0.5459224861845596,2226]
["High","A6H8Y1","Transcription factor TFIIIB component B'' homolog [OS=Homo sapiens]",1,3,4,3,2624,293.7,5.11,5.2,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","BDP1","ENSG00000145734; ENSG00000273873","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter","",281.4,226.1,281.3,330,343.8,316.3,0.7966872033127967,-0.3279146928887873,0.02867979530007738,1.5424239527379926,0.1748101808766621,0.7574332778240436,1281]
["Medium","A6NCS6","Uncharacterized protein C2orf72 [OS=Homo sapiens]",5,2,2,2,295,30.5,8.34,2.29,"","","","C2orf72","ENSG00000204128","","","",124.4,127,124.1,133.6,127.6,129.3,0.9615877080665814,-0.05650964062770734,0.06755941598335075,1.1703141133388084,0.26049576296197663,0.5841993362308603,2025]
["High","A6ND36-1","Protein FAM83G [OS=Homo sapiens]",4,3,4,3,823,90.8,6.39,4.73,"signal transduction","cytosol;nucleus","other molecular function","FAM83G","ENSG00000188522","","","",126.1,68.2,130.3,124.5,118.9,103.5,0.9357163447679447,-0.09585684073841072,0.7412016960064587,0.13006359560596845,0.8523273700174417,0.06939356522783474,6790]
["High","A6NDB9","Paralemmin-3 [OS=Homo sapiens]",9,6,8,6,673,71.7,4.53,23.73,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PALM3","ENSG00000187867; ENSG00000288318","","","",335.4,302.5,328.7,368.5,301.4,306.7,0.9897603932009011,-0.014848783209738545,0.8952195845581801,0.048070425393344475,0.9407637303136299,0.02651943449528435,7430]
["High","A6NDG6","glycerol-3-phosphate phosphatase [OS=Homo sapiens]",46,10,23,10,321,34,6.14,47.54,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","PGP","ENSG00000184207","","Glycolysis","Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism",983.1,912.8,946.5,1068.3,979.5,1018.4,0.9270106320527037,-0.10934220941115391,0.08498604174960918,1.070652397684652,0.2900222963203446,0.5375686131470033,2288]
["High","A6NDU8","UPF0600 protein C5orf51 [OS=Homo sapiens]",45,9,22,9,294,33.6,5.26,31.35,"","cytosol;nucleus","","C5orf51","ENSG00000205765","","","",692.9,510.8,696.9,624.8,622.6,610.4,1.0230380019377756,0.032859736665731686,0.8280509818215736,0.08194292355065685,0.9046344012960468,0.04352690099318853,7147]
["High","A6NED2","RCC1 domain-containing protein 1 [OS=Homo sapiens]",8,2,3,2,376,40.1,5.27,11.52,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;other cell component","","RCCD1","ENSG00000166965","","","",140.2,147.3,152.2,157.9,145.6,173,0.9227701993704092,-0.11595668158465718,0.22937992966394405,0.6394445847674637,0.47418546222294816,0.3240517649363533,3777]
["High","A6NFI3","Zinc finger protein 316 [OS=Homo sapiens]",2,2,4,2,1004,108.4,5.31,7.23,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF316","ENSG00000205903","","","Herpes simplex virus 1 infection",317,373.4,295.4,385.8,341.7,377.7,0.8919652551574374,-0.16494058114126145,0.21327223021847086,0.6710656895483206,0.4551051034560865,0.3418882943762926,3659]
["High","A6NGB9","WAS/WASL-interacting protein family member 3 [OS=Homo sapiens]",4,1,1,1,483,49.4,10.15,2.69,"other biological processes","cytosol;cytoskeleton","cytoskeletal activity","WIPF3","ENSG00000122574","","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs","Endocytosis; Pathogenic Escherichia coli infection; Yersinia infection",14.2,27.7,12.9,15.5,22.9,23.3,0.8881685575364667,-0.17109459618889125,0.6903944182093017,0.1609027285192357,0.8222391118636712,0.08500186875906174,6556]
["High","A6NHQ2","rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 [OS=Homo sapiens]",10,4,13,1,334,34.8,10.35,37.65,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","FBLL1","ENSG00000188573","","","",20.7,24.7,19.4,24.6,22.7,26.4,0.8792401628222524,-0.18567080621044496,0.19710714216019787,0.705297638812564,0.438340235256857,0.3581886636192798,3511]
["High","A6NHR9-1","structural maintenance of chromosomes flexible hinge domain-containing protein 1 [OS=Homo sapiens]",19,31,63,31,2005,226.2,7.3,124.61,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMCHD1","ENSG00000101596","","","",2690.1,2749.2,2683.6,2816.1,2908,2852.8,0.9470671221536917,-0.07846141643066877,0.011117780623760525,1.9539818997191383,0.11497699484810885,0.939389046689691,755]
["Medium","A6NHX0","Cytosolic arginine sensor for mTORC1 subunit 2 [OS=Homo sapiens]",6,1,2,1,329,36,5.16,0,"other biological processes","cytosol","other molecular function","CASTOR2","ENSG00000274070","","Amino acids regulate mTORC1","mTOR signaling pathway",13,14.2,19.1,15.8,14.1,21,0.9096267190569745,-0.13665346281545893,0.611953635490074,0.21328148081782367,0.7704182499043046,0.11327343806049589,6202]
["Medium","A6NHY2","ankyrin repeat and death domain-containing protein 1B [OS=Homo sapiens]",1,1,1,1,528,59.1,8.35,2.29,"signal transduction","","","ANKDD1B","ENSG00000189045","","","",206.2,103.7,221.2,230.6,219.8,166.3,0.8611966920706986,-0.21558531688519314,0.5335675131977375,0.2728106207490488,0.7179209276319032,0.14392338665494386,5803]
["High","A6NI28","Rho GTPase-activating protein 42 [OS=Homo sapiens]",2,2,3,1,874,98.5,7.99,7.83,"signal transduction;other biological processes","","enzyme regulator activity","ARHGAP42","ENSG00000165895","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",52,48.5,60.9,68.6,60.9,74.4,0.7915644923982345,-0.3372211967388162,0.05789904375199802,1.2373286089264501,0.24059379117381616,0.6187155843683403,1879]
["High","A6NIH7","Protein unc-119 homolog B [OS=Homo sapiens]",69,10,32,9,251,28.1,5.68,106.26,"cell organization and biogenesis;transport;developmental processes","cytosol;other cell component","other molecular function","UNC119B","ENSG00000175970","","Trafficking of myristoylated proteins to the cilium","",931.5,1274.4,954.9,873.3,874.4,864,1.2102461997932383,0.27530056410328674,0.17345410166350383,0.7608154259529987,0.4125280614647085,0.38454650402370333,3283]
["High","A6NJ78","Probable methyltransferase-like protein 15 [OS=Homo sapiens]",7,2,3,2,407,46.1,8.62,8.59,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","METTL15","ENSG00000169519","","","",33.4,54.9,42.1,41.9,38.9,39.7,1.0821576763485479,0.11391072311375379,0.6285204533380857,0.20168058491941757,0.7813226714955855,0.1071695736648553,6281]
["High","A6NK58","Putative lipoyltransferase 2, mitochondrial [OS=Homo sapiens]",10,2,2,2,231,25.2,8.27,0,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","LIPT2","ENSG00000175536","","Glyoxylate metabolism and glycine degradation","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors",32.6,27.6,35.4,38.3,35.6,38.1,0.8535714285714284,-0.22841620896421813,0.08867673684527273,1.0521902965697965,0.29716221514501695,0.5270064129371801,2330]
["High","A6NKD9","Coiled-coil domain-containing protein 85C [OS=Homo sapiens]",8,3,3,3,419,45.2,6.96,1.63,"developmental processes","other cell component","","CCDC85C","ENSG00000205476","","","",32.9,51.5,38.2,36.1,30.1,29.8,1.2770833333333333,0.352852668082263,0.20734805697475306,0.6833000299845386,0.4494651940196757,0.34730393380941776,3602]
["High","A6NKF1","SAC3 domain-containing protein 1 [OS=Homo sapiens]",7,2,5,2,404,43.5,8.69,17.18,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","","SAC3D1","","","","",156.3,146.8,156,162.5,160.7,152.5,0.9651040571788942,-0.05124359325008844,0.2751756836031497,0.5603899459581685,0.5226396831849655,0.28179761807988285,4111]
["Medium","A6NMB9","Putative fidgetin-like protein 2 [OS=Homo sapiens]",1,1,1,1,653,66.6,6.73,1.79,"cell organization and biogenesis","nucleus","other molecular function","FIGNL2","ENSG00000261308","","","",32.7,25.4,17.8,34.6,36.3,30.8,0.7463126843657818,-0.4221478884420336,0.13480701330241712,0.870287513147073,0.36320674943591197,0.4398460896235933,2898]
["High","A6ZKI3","Retrotransposon Gag-like protein 8B [OS=Homo sapiens]",29,3,6,3,113,13.2,5.07,9.43,"","","","RTL8C","ENSG00000134590","","","",78.4,84.1,77.8,66.4,76.8,65.7,1.1503111536620394,0.20202415606275823,0.06362846809648064,1.196348532606208,0.25104147493548296,0.600254522153969,1979]
["High","A7E2V4","Zinc finger SWIM domain-containing protein 8 [OS=Homo sapiens]",2,2,2,2,1837,197.2,6.8,3.1,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","ZSWIM8","ENSG00000214655","","Regulation of expression of SLITs and ROBOs","",57,42.7,49.4,55.7,57.9,55.5,0.881726788882318,-0.1815964021265411,0.1877793747002228,0.726352111461798,0.42758278146962364,0.36897979191810687,3429]
["High","A8CG34-1","Nuclear envelope pore membrane protein POM 121C [OS=Homo sapiens]",5,6,12,1,1229,125,10.37,18.15,"","","","","","","","",119.8,143.1,125.1,106.6,91.1,101.4,1.2972250083584087,0.3754287419551381,0.024226876710091102,1.6157025707986592,0.1608532766601967,0.7935700878801436,1176]
["Low","A8K2U0","Alpha-2-macroglobulin-like protein 1 [OS=Homo sapiens]",0,1,1,1,1454,161,5.73,0,"other biological processes","non-structural extracellular","enzyme regulator activity;other molecular function","A2ML1","ENSG00000166535","","","",71.5,67.2,76,59.4,81.7,72.8,1.0037400654511455,0.005385708693729046,0.9712779453442226,0.01265647260884663,0.984261933452004,0.006889311004649331,7705]
["High","A8MQ14","Zinc finger protein 850 [OS=Homo sapiens]",8,4,5,4,1090,125.4,8.7,12.46,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF850","ENSG00000267041","","","Herpes simplex virus 1 infection",350.2,316.3,336.4,385.4,376.8,402.6,0.8610061813186812,-0.2159044998601369,0.012222174245589884,1.9128515290469927,0.1195873891097316,0.9223146157390867,798]
["Medium","A8MW92","PHD finger protein 20-like protein 1 [OS=Homo sapiens]",1,1,1,1,1017,114.9,6.83,2.1,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF20L1","ENSG00000129292","","","",83.5,86.6,95.5,111.4,100,86.7,0.8909761824890977,-0.16654122864424392,0.24674683364330702,0.6077484116676979,0.49577953604913566,0.30471140327282614,3886]
["High","A9UHW6","MIF4G domain-containing protein [OS=Homo sapiens]",18,4,5,4,222,25.4,5.33,10.69,"other biological processes","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","MIF4GD","ENSG00000125457","","","",129.6,125.1,120.1,138.3,125.2,140.4,0.9279524634810596,-0.10787719304389981,0.15200827882841628,0.8181327584263687,0.3832355960904987,0.41653415912452,3097]
["Medium","B0YJ81","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 [OS=Homo sapiens]",4,1,1,1,288,32.4,9.04,2.63,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","HACD1","ENSG00000165996","","Synthesis of very long-chain fatty acyl-CoAs","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism",31.1,35.7,38,31,33.8,37.3,1.0264446620959844,0.03765585065964888,0.7579208954105612,0.12037611953870134,0.8611534271486702,0.06491946570325186,6872]
["High","B2RTY4","unconventional myosin-IXa [OS=Homo sapiens]",4,9,9,8,2548,292.5,8.88,12.24,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","MYO9A","ENSG00000066933","","RHOA GTPase cycle; RHOB GTPase cycle; RHOV GTPase cycle","",340.6,352.4,320.6,299.2,278.4,285.3,1.1746436435276397,0.23222314683965897,0.010664398289711373,1.972063643433497,0.11191884656729355,0.9510967743207404,744]
["High","L0R6Q1","SLC35A4 upstream open reading frame protein [OS=Homo sapiens]",22,1,1,1,103,11.1,8.1,3.21,"stress response","other membranes","","SLC35A4","ENSG00000176087","","","",15.9,14.5,19.9,16.7,21.4,17.9,0.8982142857142857,-0.15486842713943932,0.42598464729593194,0.3706060528099791,0.6474767619401668,0.1887758138756809,5137]
["High","O00115","Deoxyribonuclease-2-alpha [OS=Homo sapiens]",4,2,5,2,360,39.6,8.05,8.52,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","other cytoplasmic organelle","nucleic acid binding activity;other molecular function","DNASE2","ENSG00000105612","","Lysosome Vesicle Biogenesis","Lysosome",542.8,564.7,531.9,638,611.3,621.6,0.8762627612379069,-0.19056454527556022,0.003382507113905236,2.470761281344814,0.0617070456667572,1.2096652456993506,428]
["High","O00116","Alkyldihydroxyacetonephosphate synthase, peroxisomal [OS=Homo sapiens]",39,18,47,18,658,72.9,7.34,100.26,"other metabolic processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","AGPS","ENSG00000018510","Triacylglyceride synthesis","Plasmalogen biosynthesis; TYSND1 cleaves peroxisomal proteins","Ether lipid metabolism; Metabolic pathways; Peroxisome",1379.2,1214.2,1380.2,1369.3,1490.7,1442.4,{"$f":"AVERAGE(T66:V66)/AVERAGE(W66:Y66)","v":0.9235775381182598},{"$f":"LOG(Z66,2)","v":-0.11469500843563452},{"$f":"TTEST(T66:V66,W66:Y66,2,2)","v":0.16952602212565288},{"$f":"-LOG10(AB66)","v":0.7707636284451711},{"$f":"AB66*7808/AF66","v":0.40702926837549125},{"$f":"-LOG10(AD66)","v":0.39037436070856635},3252]
["High","O00139-2","Isoform 2 of Kinesin-like protein KIF2A [OS=Homo sapiens]",40,19,66,16,660,75,6.4,111.99,"","","","KIF2A","","","","",1877.3,1696.7,1846.7,1959.8,1793.9,1872.5,0.9634744587821265,-0.0536816729712165,0.40440355708935644,0.3931850330575819,0.6311379120035369,0.19987573128235567,5003]
["High","O00148","ATP-dependent RNA helicase DDX39A [OS=Homo sapiens]",49,19,142,7,427,49.1,5.68,236.83,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","other molecular function","DDX39A","ENSG00000123136","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",1623,1240.5,1614.9,1771.5,2006.7,1870.1,0.7928757325212896,-0.3348333249528574,0.05303876478316793,1.275406598745454,0.23045446601389827,0.6374148711957922,1797]
["High","O00151","PDZ and LIM domain protein 1 [OS=Homo sapiens]",33,10,31,9,329,36,7.02,72.73,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PDLIM1","ENSG00000107438","","","",1417.7,1647.7,1279.5,1644.4,1293.6,1403.2,1.000852298903529,1.229083702500459E-3,0.9938013555975089,2.7004151894835125E-3,0.9964814414415499,1.5307852269962833E-3,7787]
["High","O00154","cytosolic acyl coenzyme A thioester hydrolase [OS=Homo sapiens]",47,16,63,16,380,41.8,8.54,116.69,"other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","ACOT7","ENSG00000097021","","Mitochondrial Fatty Acid Beta-Oxidation","Fatty acid elongation; Biosynthesis of unsaturated fatty acids",2152.2,2077.1,2180.5,2074.2,2321.5,2140.6,0.9806465431513242,-0.028194858880622592,0.6263384236301153,0.20319094506274446,0.7802250178213049,0.10778012820066166,6268]
["High","O00159-3","Isoform 3 of Unconventional myosin-Ic [OS=Homo sapiens]",19,17,24,17,1044,119.6,9.45,43.63,"","","","MYO1C","","","","",1255.3,1284.3,1256.6,1322.1,1346.8,1310.5,0.9539629089812535,-0.06799492097216718,0.01289533421860888,1.8895673974254934,0.12189681547082099,0.9140076400872403,826]
["High","O00161","Synaptosomal-associated protein 23 [OS=Homo sapiens]",67,13,35,13,211,23.3,5.01,82.87,"cell-cell signaling;cell organization and biogenesis;stress response;transport","plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP23","ENSG00000092531","Insulin signaling","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding","SNARE interactions in vesicular transport; Platelet activation",1268,1174.2,1402,1392.4,1305.7,1306.3,0.9599940065927477,-0.05890269601806035,0.5000458243525184,0.3009901949609237,0.6958399209667553,0.1574906590057455,5611]
["High","O00165","HCLS1-associated protein X-1 [OS=Homo sapiens]",28,6,14,6,279,31.6,4.92,39.84,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HAX1","ENSG00000143575","","","",562.3,624.6,536.7,746.6,682.2,698.6,0.8101908432828806,-0.3036663150037557,0.014321588254661208,1.8440088163866637,0.1282373407022875,0.8919854966605955,872]
["High","O00170","AH receptor-interacting protein [OS=Homo sapiens]",32,8,21,8,330,37.6,6.29,43.43,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","AIP","ENSG00000110711","Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway","Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Cushing syndrome; Chemical carcinogenesis",584.6,607.5,690.6,851.4,767.7,742,0.7973825759180043,-0.3266560143970321,0.025887711757942952,1.586906335614474,0.16732719652816108,0.7764334652409516,1208]
["High","O00178","GTP-binding protein 1 [OS=Homo sapiens]",29,15,40,15,669,72.4,8.34,104.63,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;other cytoplasmic organelle","nucleic acid binding activity;other molecular function","GTPBP1","ENSG00000100226","","","",1258.1,1218.2,1323.5,1233.9,1408.1,1317.5,0.95966662457381,-0.05939477509923581,0.41740085000615157,0.379446670860873,0.6401622150555945,0.19370996323957587,5091]
["High","O00180","potassium channel subfamily K member 1 [OS=Homo sapiens]",12,2,2,2,336,38.1,6.37,7.92,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","KCNK1","ENSG00000135750","","Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK); Phase 4 - resting membrane potential","",36.7,28.4,27.3,43.4,43.1,32.7,0.7751677852348993,-0.36741947904610417,0.12420404742143139,0.9058642516300254,0.35022939771272527,0.4556474027169645,2769]
["High","O00186","syntaxin-binding protein 3 [OS=Homo sapiens]",23,13,30,13,592,67.7,7.8,52.2,"cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STXBP3","ENSG00000116266","Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation","",1045,1578.1,1066.7,1077.7,1072.8,1093.8,1.137317757297414,0.18563538776653452,0.442257906763447,0.3543243939568736,0.6543774371819204,0.18417168347536192,5277]
["High","O00189","AP-4 complex subunit mu-1 [OS=Homo sapiens]",8,3,4,3,453,49.9,7.2,3.41,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","AP4M1","ENSG00000221838","","Lysosome Vesicle Biogenesis","Lysosome",233.3,118.2,293.7,264.4,294.3,262.5,0.7856794934242572,-0.34798718895295927,0.3263513906711994,0.48631453231826893,0.5668857971881479,0.2465044237288811,4495]
["High","O00192","armadillo repeat protein deleted in velo-cardio-facial syndrome [OS=Homo sapiens]",19,13,19,13,962,104.6,6.81,45.39,"cell adhesion;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","ARVCF","ENSG00000099889","22q11.2 copy number variation syndrome","","",829.9,793.2,776.8,684.6,618.1,656.2,1.2251263464189084,0.2929305410258045,0.00408979561363182,2.3882983951931016,0.0680876847574355,1.1669314332495497,469]
["High","O00193","Small acidic protein [OS=Homo sapiens]",31,7,43,7,183,20.3,4.72,97.37,"","","","SMAP","ENSG00000110696","","","",1610.7,1880.1,1497.4,1795.8,1630.7,1591.8,0.9940019528525598,-0.008679408725619783,0.9420023099165555,0.025948032257246033,0.9684205445462101,0.013936005797415787,7595]
["High","O00203-1","AP-3 complex subunit beta-1 [OS=Homo sapiens]",23,23,56,18,1094,121.2,6.04,99.11,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","AP3B1","ENSG00000132842","","Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions","Lysosome",2438,2722,2495.7,2462.5,2727,2615,0.9809340764943302,-0.0277719112567916,0.6902234097326895,0.1610103151904029,0.8221608517456658,0.08504320655787061,6555]
["High","O00213","amyloid-beta A4 precursor protein-binding family B member 1 [OS=Homo sapiens]",9,5,6,5,710,77.2,5.06,9.96,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","APBB1","ENSG00000166313","Alzheimer's disease and miRNA effects; Alzheimer's disease","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks","Alzheimer disease",239.4,191,213.5,331.8,276.1,281.6,0.7238898257448003,-0.46615795551635836,0.02222637742589509,1.6531313151753495,0.1556444438936223,0.8078663779008934,1115]
["High","O00214-1","Galectin-8 [OS=Homo sapiens]",7,2,2,2,317,35.8,8.25,3.31,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","LGALS8","ENSG00000116977","","","",33.7,28.1,34.5,29.3,48.8,38.4,0.8266094420600858,-0.2747222516981834,0.3233213667107733,0.49036559406471303,0.564258656968645,0.24852176916668856,4474]
["High","O00217","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [OS=Homo sapiens]",16,3,5,3,210,23.7,6.34,9.73,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS8","ENSG00000110717","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",100.6,113.8,115.4,141.8,118.3,103,0.9082897273478379,-0.13877553136274043,0.41504982966120996,0.381899760040234,0.6389410626961214,0.19453920025527485,5072]
["High","O00220","Tumor necrosis factor receptor superfamily member 10A [OS=Homo sapiens]",7,3,5,3,468,50.1,7.03,2.26,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TNFRSF10A","ENSG00000104689","Apoptosis modulation and signaling","Cell surface interactions at the vascular wall; Regulation by c-FLIP; RIPK1-mediated regulated necrosis; CASP8 activity is inhibited; TP53 Regulates Transcription of Death Receptors and Ligands; Dimerization of procaspase-8; TRAIL  signaling","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; p53 signaling pathway; Apoptosis; Necroptosis; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Salmonella infection; Influenza A; Lipid and atherosclerosis",135.8,192.5,124.1,167.5,164.6,155.6,0.9276194381792083,-0.10839504304604751,0.6120603277463679,0.21320576949478437,0.7704283474195777,0.11326774600111543,6203]
["High","O00221","NF-kappa-B inhibitor epsilon [OS=Homo sapiens]",9,3,8,3,500,52.8,6.68,10.8,"other biological processes","cytosol;nucleus;other cell component","","NFKBIE","ENSG00000146232","TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19","Activation of NF-kappaB in B cells","Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Epstein-Barr virus infection; PD-L1 expression and PD-1 checkpoint pathway in cancer",220.6,69.7,175.5,164.8,125.5,143.7,1.0732718894009219,0.10201559687902477,0.8295652474808979,0.08114944989699474,0.9051488893698785,0.04327997713369475,7156]
["High","O00231","26S proteasome non-ATPase regulatory subunit 11 [OS=Homo sapiens]",60,23,74,23,422,47.4,6.48,164.89,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD11","ENSG00000108671","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling pathway","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",3450.7,3429.1,3480.9,3495.4,3543,3551.2,0.9783844526705446,-0.031526616444506876,0.029385421604387722,1.5318680739083839,0.17703809559186678,0.7519332707843229,1296]
["High","O00232-1","26s proteasome non-atpase regulatory subunit 12 [OS=Homo sapiens]",51,20,144,20,456,52.9,7.65,244.33,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","","PSMD12","ENSCANG00000030312; ENSCATG00000032968; ENSCSAG00000004164; ENSG00000197170; ENSMFAG00000032701; ENSMLEG00000034943; ENSMMUG00000002132; ENSMNEG00000032475; ENSNLEG00000001265; ENSPANG00000020562; ENSPPYG00000008565; ENSRROG00000042400","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease","Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",4125.4,3413.1,4308.8,3854.9,4510.4,4193.6,0.9433389866946945,-0.08415180167252079,0.5148242573069712,0.28834099835201044,0.7060860356671054,0.15114237750492268,5693]
["High","O00233-1","26S proteasome non-ATPase regulatory subunit 9 [OS=Homo sapiens]",33,7,19,7,223,24.7,6.95,43.16,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMD9","ENSG00000110801","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",709.4,776,633.5,734.2,585.2,563.8,1.125159303313509,0.17012927684667342,0.30961232606676464,0.5091817578204749,0.5526870237606992,0.2575207318634577,4374]
["Medium","O00244","Copper transport protein ATOX1 [OS=Homo sapiens]",12,1,3,1,68,7.4,7.24,6.45,"stress response;transport;other biological processes","cytosol","other molecular function","ATOX1","ENSG00000177556","Copper homeostasis","Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface","Mineral absorption",157.8,139,169.3,163.2,177.2,150.1,0.9502548419979613,-0.07361362356765686,0.5285156649616595,0.2769421358767347,0.7153146666702439,0.1455028701762416,5769]
["High","O00255-2","Isoform 2 of Menin [OS=Homo sapiens]",26,12,20,12,610,67.5,6.55,48.24,"","","","MEN1","","","","",722.9,685.6,743.6,651.7,655.2,683.1,1.0814572864321608,0.11297668530042988,0.05149213751480234,1.2882590795921556,0.22869773021363862,0.6407381456712732,1758]
["High","O00258-1","Tail-anchored protein insertion receptor WRB [OS=Homo sapiens]",13,2,2,2,174,19.8,9.67,2.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus","","GET1; WRB","ENSANAG00000014374; ENSCANG00000035340; ENSCATG00000041953; ENSCCAG00000026562; ENSCSAG00000008355; ENSG00000182093; ENSMLEG00000038301; ENSMNEG00000036276; ENSNLEG00000033928; ENSPANG00000032093; ENSPPAG00000034665; ENSPPYG00000011427; ENSPTRG00000013915; ENSSBOG00000020756","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",22.5,20.6,26.5,21.8,22.1,26.9,0.9830508474576268,-0.024662054234269565,0.8756469856775122,0.057670943000637,0.9307176237639553,0.03118206235127654,7346]
["High","O00264","Membrane-associated progesterone receptor component 1 [OS=Homo sapiens]",69,19,142,17,195,21.7,4.7,283.11,"other metabolic processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PGRMC1","ENSG00000101856","","Neutrophil degranulation","",5080.4,6166.2,5696.4,5674.1,5034.1,5108.3,1.0712230898112731,0.09925896285963261,0.37189219367532755,0.42958293774565487,0.6046926797619653,0.218465288808028,4802]
["High","O00267","Transcription elongation factor Spt5 [OS=Homo sapiens]",34,28,82,28,1087,120.9,5.06,189.56,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SUPT5H","ENSG00000196235","Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","",3104.5,2776.8,3107.5,3172.1,3275.1,3277.1,0.9243647357650423,-0.11346587241124839,0.10017039332929378,0.9992606209209205,0.31486732331526807,0.5018724077668277,2484]
["High","O00268","Transcription initiation factor TFIID subunit 4 [OS=Homo sapiens]",10,7,11,7,1085,110,9.94,32.34,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","TAF4","ENSG00000130699","","RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors; Huntington disease",355.3,287,336,348.2,320.8,347.9,0.9620414986724358,-0.05582896738099326,0.5943221886294368,0.22597805533923487,0.7601093609858546,0.11912391896150074,6105]
["High","O00273-1","DNA fragmentation factor subunit alpha [OS=Homo sapiens]",56,13,36,4,331,36.5,4.79,78.92,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DFFA","ENSG00000160049","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis","Apoptosis induced DNA fragmentation","Apoptosis",806.2,1139,788.6,744.4,711.5,761.7,1.2327741702741701,0.3019085391848758,0.2086933654672138,0.6804913572918946,0.45050533524136166,0.346300061394879,3617]
["High","O00291","Huntingtin-interacting protein 1 [OS=Homo sapiens]",38,32,79,31,1037,116.1,5.3,156.45,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HIP1","ENSG00000127946","","Clathrin-mediated endocytosis; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","Huntington disease; Pathways of neurodegeneration",3849.3,3240.9,3747.3,3797.6,3702.9,3812.3,0.9579856445795913,-0.06192405755743718,0.45393196721521534,0.34300923189405075,0.6633540707498412,0.1782546014183213,5343]
["High","O00299","chloride intracellular channel protein 1 [OS=Homo sapiens]",87,18,146,17,241,26.9,5.17,373.46,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion;nucleus;other cell component","transporter activity","CLIC1","ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685","VEGFA-VEGFR2 signaling pathway","","",5357.2,5807.2,5786.9,5656.5,5913.6,5562.1,0.9894409357817443,-0.015314506056268759,0.7550407697570951,0.12202959724168484,0.8592564247578194,0.06587721190946035,6861]
["Medium","O00300","Tumor necrosis factor receptor superfamily member 11B [OS=Homo sapiens]",2,1,1,1,401,46,8.29,2.13,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","TNFRSF11B","ENSG00000164761","Osteoclast signaling; RANKL/RANK signaling pathway; Ectoderm differentiation; Vitamin D receptor pathway; Osteoblast signaling; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Overlap between signal transduction pathways contributing to LMNA laminopathies; Monoamine transport","TNFs bind their physiological receptors","Cytokine-cytokine receptor interaction; Osteoclast differentiation",91,28,102.8,103.7,118.2,107.3,0.6737545565006076,-0.5697049702599157,0.2042412117900835,0.689856621469644,0.4472000509413831,0.34949815565034437,3566]
["High","O00303","Eukaryotic translation initiation factor 3 subunit F [OS=Homo sapiens]",42,11,55,11,357,37.5,5.45,110.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3F","ENSG00000175390","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",2078.5,1918.3,2061.8,2060.7,2239.1,2138.9,0.940966344137792,-0.08778497237333575,0.1552937304048001,0.8088460774688818,0.3873908776359997,0.4118506103566949,3130]
["High","O00308","NEDD4-like E3 ubiquitin-protein ligase WWP2 [OS=Homo sapiens]",14,10,14,9,870,98.9,7.12,23.19,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","WWP2","ENSG00000198373","","RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle","Ubiquitin mediated proteolysis",381.3,394.7,391.8,474.3,481.6,440.9,0.8360538373424969,-0.25833224783695846,0.004409523956391395,2.3556082935869807,0.06997878669004881,1.1550335916957055,492]
["High","O00311-1","Cell division cycle 7-related protein kinase [OS=Homo sapiens]",5,2,5,2,574,63.8,8.73,10.07,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CDC7","ENSG00000097046","Cell cycle; Retinoblastoma gene in cancer; DNA replication","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Transcriptional Regulation by E2F6","Cell cycle",42.2,41,42.9,46.7,52.5,46.3,0.8666666666666666,-0.20645087746742652,0.03584147624164478,1.4456141108850025,0.19180962748098862,0.7171295981198186,1459]
["High","O00330-1","Pyruvate dehydrogenase protein X component, mitochondrial [OS=Homo sapiens]",24,11,21,11,501,54.1,8.66,44.04,"other metabolic processes","mitochondrion;other cell component","other molecular function","PDHX","ENSG00000110435","Amino acid metabolism","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Metabolic pathways",883.5,859.1,875.6,868.8,867.3,901.7,0.9925695655470466,-0.010759875903644356,0.6496967572679693,0.18728930085682888,0.7953641079881316,0.0994340111051339,6378]
["Low","O00339-1","Matrilin-2 [OS=Homo sapiens]",1,1,2,1,956,106.8,6.27,3.59,"","non-structural extracellular;extracellular matrix","extracellular structural activity;other molecular function","MATN2","ENSG00000132561","","","",166.2,105.1,161.9,164.7,171.6,148.3,0.8939331407346264,-0.16176116184301947,0.45771085314903165,0.3394087895459298,0.6658852881288688,0.17660058017432986,5367]
["High","O00391","Sulfhydryl oxidase 1 [OS=Homo sapiens]",3,2,2,2,747,82.5,8.92,3.63,"cell organization and biogenesis;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","QSOX1","ENSG00000116260","","Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",193.2,177.9,180.8,134.4,154.5,138.7,1.2906922357343313,0.3681450324712055,0.005776422632272612,2.2383410390968144,0.08053983555854384,1.0939892614443796,560]
["High","O00399","Dynactin subunit 6 [OS=Homo sapiens]",22,4,8,4,190,20.7,6.32,12.06,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","DCTN6","ENSG00000104671","","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","Vasopressin-regulated water reabsorption; Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection",411.9,360,416.9,470.6,444.7,457.9,0.8657151179726188,-0.2080357414186602,0.03534528371742887,1.4516685278966066,0.19059114313928496,0.7198972850990992,1448]
["High","O00400","Acetyl-coenzyme A transporter 1 [OS=Homo sapiens]",12,6,10,6,549,60.9,7.33,16.81,"transport;signal transduction","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC33A1","ENSG00000169359","Ganglio sphingolipid metabolism","Transport of vitamins, nucleosides, and related molecules; Defective SLC33A1 causes spastic paraplegia 42 (SPG42)","Glycosphingolipid biosynthesis; Metabolic pathways",396.2,308.3,385.5,382.2,399.6,376.2,0.9412780656303972,-0.08730711832494799,0.4718912793277218,0.3261580484566782,0.6755641930676296,0.17033337740365384,5454]
["High","O00401","Neural Wiskott-Aldrich syndrome protein [OS=Homo sapiens]",30,10,24,10,505,54.8,7.93,39.06,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity","WASL","ENSG00000106299","Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 signaling pathway","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle; RHOV GTPase cycle; NOSTRIN mediated eNOS trafficking; Nephrin family interactions; EPHB-mediated forward signaling; DCC mediated attractive signaling","Endocytosis; Adherens junction; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",807.4,821.9,788.2,892.9,804.1,819,0.9608505564387918,-0.05761603251508555,0.32285169510176037,0.49099692903076614,0.5640693746597774,0.2486674790324899,4469]
["High","O00410","Importin-5 [OS=Homo sapiens]",64,47,286,44,1097,123.6,4.94,616.8,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","IPO5","ENSG00000065150","","vRNP Assembly","Nucleocytoplasmic transport",8645.6,8288,8738,8759.2,8957.6,8917.8,0.9638440224369803,-0.05312839891310886,0.09909254470500001,1.0039590187263816,0.313625694793936,0.5035883635574823,2467]
["High","O00411","DNA-directed RNA polymerase, mitochondrial [OS=Homo sapiens]",17,16,27,16,1230,138.5,8.98,50.34,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","POLRMT","ENSG00000099821","Mitochondrial gene expression","Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis","",645.9,677.6,655.4,582.7,660.3,615.7,1.0646688545757788,0.09040477678915027,0.17546546667086374,0.7558083442125717,0.41440845848944463,0.38257138878936503,3306]
["High","O00418","Eukaryotic elongation factor 2 kinase [OS=Homo sapiens]",10,7,10,7,725,82.1,5.33,18.04,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;kinase activity;other molecular function","EEF2K","ENSG00000103319","Translation factors; AMP-activated protein kinase (AMPK) signaling; BDNF-TrkB signaling","mTORC1-mediated signalling","AMPK signaling pathway; Oxytocin signaling pathway",330.2,397.9,329,368.9,357.8,368.5,0.9652118334550766,-0.05108249184685211,0.611090945311668,0.21389415128313777,0.7698286706991777,0.11360591852776658,6198]
["High","O00422","Histone deacetylase complex subunit SAP18 [OS=Homo sapiens]",60,10,53,10,153,17.6,9.35,91.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SAP18","ENSG00000150459","Hedgehog signaling pathway","Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression","Nucleocytoplasmic transport; mRNA surveillance pathway",3704.3,6210.6,3719.3,3877.3,3810.1,3792.1,1.1876998127096128,0.2481702457008065,0.43736540924963496,0.359155567814276,0.6534537151590413,0.18478516854694743,5226]
["High","O00423-1","Echinoderm microtubule-associated protein-like 1 [OS=Homo sapiens]",5,4,7,4,815,89.8,7.06,15.94,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","EML1","ENSG00000066629","","","",200,172.7,204.9,184.5,206.8,199.1,0.9783197831978321,-0.031621979173224915,0.739360645909096,0.13114366942340952,0.851213200126544,0.06996165020684163,6782]
["High","O00425","Insulin-like growth factor 2 mRNA-binding protein 3 [OS=Homo sapiens]",56,30,200,24,579,63.7,8.87,408.36,"protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP3","ENSG00000136231","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",8107.1,7211.4,8005.8,8854.6,9176.2,9095.9,0.8598281398032195,-0.2178797683644348,0.0133088171444759,1.8758605418547671,0.124598614225501,0.9044867878338704,834]
["High","O00429","Dynamin-1-like protein [OS=Homo sapiens]",73,46,289,1,736,81.8,6.81,653.37,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","DNM1L","ENSG00000087470","Synaptic vesicle pathway; CAMKK2 pathway","Apoptotic execution phase","Necroptosis; NOD-like receptor signaling pathway; TNF signaling pathway",76,95.7,85.5,88.2,97.8,104.9,0.8841526297696805,-0.17763265377235885,0.20696442125680234,0.6841043066198715,0.4495071491441204,0.3472633966801375,3595]
["High","O00429-6","Isoform 6 of Dynamin-1-like protein [OS=Homo sapiens]",71,46,287,0,749,83.3,7.08,646.88,"","","","DNM1L","","","","",10217.6,9122.9,10318.9,10282.3,10316.3,10517.7,0.9531788805224272,-0.06918110863730131,0.2808959271131047,0.5514545578618882,0.5274736409088796,0.2777992381987032,4158]
["High","O00429-8","Isoform 8 of Dynamin-1-like protein [OS=Homo sapiens]",72,46,285,1,738,82,6.96,642.25,"","","","DNM1L","","","","",193.8,216.6,182.1,172.6,214.5,194.9,1.018041237113402,0.0257960008773375,0.8353673612058118,0.07812249714023259,0.9086860345911087,0.041586146478818226,7178]
["High","O00442","RNA 3'-terminal phosphate cyclase [OS=Homo sapiens]",44,14,50,14,366,39.3,7.85,106.23,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RTCA","ENSG00000137996","","","",1609.8,1355.3,1664.1,1698.9,1737.8,1758,0.8911390455656727,-0.16627754002313358,0.12319456947387468,0.9094084358364515,0.3481372415678659,0.45824951609432746,2763]
["High","O00443","phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [OS=Homo sapiens]",15,23,41,23,1686,190.6,8.02,76.67,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2A","ENSG00000011405","Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection",1834.2,1567.8,1739.8,2047.1,1971.5,1967.8,0.8589135373513298,-0.21941518530790058,0.02660944192944213,1.5749642336600098,0.16932886926249727,0.7712689917283786,1227]
["High","O00458","Interferon-related developmental regulator 1 [OS=Homo sapiens]",11,3,3,3,451,50.2,7.18,9.27,"other biological processes","nucleus","","IFRD1","ENSG00000006652","Hypertrophy model","","",23.5,29.3,21.7,39.4,32.3,33.3,0.7095238095238097,-0.49507699720396076,0.033335152904525836,1.4770975484748345,0.18644761739150265,0.7294431621033415,1396]
["High","O00459","Phosphatidylinositol 3-kinase regulatory subunit beta [OS=Homo sapiens]",16,7,14,7,728,81.5,6.43,30.92,"other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R2","ENSG00000105647","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway","Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOU GTPase cycle; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",439.7,334.8,407.2,396.6,400.4,406.5,0.9818861653510594,-0.026372319026659923,0.8269273507668848,0.0825326434667647,0.9040393103875437,0.04381268466489242,7142]
["High","O00461","Golgi integral membrane protein 4 [OS=Homo sapiens]",32,17,34,17,696,81.8,4.77,79.63,"","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","GOLIM4","ENSG00000173905","","Intra-Golgi traffic","",1290.6,1192,1250.9,1261.9,1231.9,1193.5,1.0125294931250508,0.01796393166694085,0.6811290918445949,0.16677057008039772,0.8153082859301851,0.08867814394424993,6523]
["High","O00462","Beta-mannosidase [OS=Homo sapiens]",8,7,11,6,879,100.8,5.52,16.56,"protein metabolism;other metabolic processes","plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","MANBA","ENSG00000109323","","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","Other glycan degradation; Lysosome",255.3,260.6,291.8,260.6,279.6,292.4,0.9700936824405476,-0.04380401906575838,0.6015967540702292,0.220694515656426,0.7647781595213854,0.11646452310484072,6142]
["High","O00463","TNF receptor-associated factor 5 [OS=Homo sapiens]",4,2,4,2,557,64.4,7.43,1.67,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","signal transduction activity or receptor binding;other molecular function","TRAF5","ENSG00000082512","RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Small cell lung cancer; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling","","NF-kappa B signaling pathway; Necroptosis; NOD-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Shigellosis; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Small cell lung cancer",24.3,24.5,26.8,30.9,29.2,26.8,0.8699654775604143,-0.20096994259332746,0.05844420406637463,1.2332585515132584,0.2413180038869662,0.6174102756996628,1891]
["High","O00468","Agrin [OS=Homo sapiens]",18,26,37,26,2067,217.1,6.39,78.62,"","","","","","","","",1451.1,1665.4,1382.3,1385.7,1285.8,1387.8,1.1082698987510162,0.14830926601925065,0.18517856290574838,0.7324092906055149,0.424632663485487,0.37198660219568347,3405]
["High","O00469-1","procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [OS=Homo sapiens]",13,7,15,7,737,84.6,6.71,30.91,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","PLOD2","ENSG00000152952","Clear cell renal cell carcinoma pathways; Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","Lysine degradation; Metabolic pathways",718.5,653.2,717.1,638.9,696.8,662.7,1.045236188951161,0.06382898070488462,0.3318694314334122,0.4790327487097648,0.5726489548358193,0.2421115275923515,4525]
["High","O00471","Exocyst complex component 5 [OS=Homo sapiens]",20,15,29,15,708,81.8,6.71,45.03,"cell organization and biogenesis;transport;other biological processes","cytosol;other cell component","other molecular function","EXOC5","ENSG00000070367","Ciliary landscape","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium","Salmonella infection",1368.7,1133.2,1297.8,1355.9,1351.7,1366,0.9327621759622937,-0.10041880726876773,0.2614461622084685,0.5826177288349674,0.507299113947247,0.29473589622420304,4024]
["High","O00483","Cytochrome c oxidase subunit NDUFA4 [OS=Homo sapiens]",56,5,13,5,81,9.4,9.38,22.67,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NDUFA4","ENSG00000189043","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; Oxidative phosphorylation","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",524.5,532.2,571.6,518.8,593.4,600.4,0.9507765969870374,-0.0728217025728082,0.40067134497520557,0.3972117161251844,0.6274452189262746,0.20242418563430364,4986]
["High","O00487","26S proteasome non-ATPase regulatory subunit 14 [OS=Homo sapiens]",41,12,33,12,310,34.6,6.52,69.71,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMD14","ENSG00000115233","Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Metalloprotease DUBs","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",1777.1,1547.5,1755.7,1671.6,1828.8,1808.4,0.9569582579867392,-0.06347209839854114,0.4370398926145524,0.3594789192043312,0.653217358639821,0.18494228281271335,5224]
["High","O00499","Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",35,15,33,1,593,64.7,5.06,96.43,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","BIN1","ENSG00000136717","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway","Clathrin-mediated endocytosis","Endocytosis; Fc gamma R-mediated phagocytosis",1579.9,1534.2,1552.6,1855.3,1753.5,1732.3,{"$f":"AVERAGE(T130:V130)/AVERAGE(W130:Y130)","v":0.8737338750444665},{"$f":"LOG(Z130,2)","v":-0.19473416941565103},{"$f":"TTEST(T130:V130,W130:Y130,2,2)","v":0.005025821785022518},{"$f":"-LOG10(AB130)","v":2.298792915495443},{"$f":"AB130*7808/AF130","v":0.07517551053152456},{"$f":"-LOG10(AD130)","v":1.12392361383907},522]
["High","O00499-2","Isoform IIB of Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",39,15,35,1,518,56.5,5.12,96.18,"","","","BIN1","","","","",268.6,259.6,234.4,283.5,265.6,281.5,0.9181314712256201,-0.12322734069867981,0.12469757925579804,0.9041419773639072,0.35060810184705476,0.45517805245552945,2777]
["High","O00505","Importin subunit alpha-4 [OS=Homo sapiens]",34,14,51,10,521,57.8,4.94,112.11,"cell organization and biogenesis;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","KPNA3","ENSG00000102753","","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis",1080.1,1268,1032,1120.9,1134.3,1132.4,0.9977860432164364,-0.003197605460103846,0.9740092996120969,0.011436896559847656,0.9854949606545618,6.345592151165925E-3,7717]
["High","O00506","serine/threonine-protein kinase 25 [OS=Homo sapiens]",19,6,24,2,426,48.1,6.74,36.62,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","kinase activity;other molecular function","STK25","ENSG00000115694","","","",62,73.9,57.4,58.1,53.1,60.4,1.1264568764568765,0.17179208471169025,0.2490583921694987,0.6036988198761909,0.49722524317551675,0.3034468311696862,3911]
["High","O00507-1","Probable ubiquitin carboxyl-terminal hydrolase FAF-Y [OS=Homo sapiens]",14,31,68,5,2555,290.9,5.86,132.56,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","USP9Y","ENSG00000114374","","","",69.9,60.7,49.2,78.7,83.5,81.3,0.7383983572895277,-0.43752875145525716,0.0259460522469733,1.5859287117184306,0.16756557150071755,0.7758152079205671,1209]
["High","O00515","Ladinin-1 [OS=Homo sapiens]",14,6,8,6,517,57.1,9.67,18.53,"","extracellular matrix;cytoskeleton","other molecular function","LAD1","ENSG00000159166","","","",449.1,419.1,413.9,511.1,401.9,409.8,0.9692319322648926,-0.045086158359234824,0.7312653831104822,0.13592498486911112,0.8465115064976493,0.07236713421839878,6745]
["High","O00522","Krev interaction trapped protein 1 [OS=Homo sapiens]",1,1,1,1,736,84.3,8.41,3.49,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","KRIT1","ENSG00000001631","","","Rap1 signaling pathway",83.5,81.4,82.9,94.1,96.4,104.6,0.8397153507285666,-0.25202773329140554,0.008306682861492417,2.0805723700250742,0.09978243043466582,1.0009459220092944,650]
["High","O00534","von Willebrand factor A domain-containing protein 5A [OS=Homo sapiens]",10,6,8,6,786,86.4,6.58,19.04,"","nucleus","","VWA5A","ENSG00000110002","","","",303,299.5,311.8,247.7,275.1,271.1,1.1516563798967123,0.20371032357838695,0.012471777638983534,1.904071640845459,0.1200735386007194,0.9205526903979796,811]
["High","O00541-1","Pescadillo homolog [OS=Homo sapiens]",35,19,77,19,588,68,7.33,173.63,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PES1","ENSG00000100029","","Major pathway of rRNA processing in the nucleolus and cytosol","",4393.2,4062.1,4412.1,4460.2,4686.2,4639.3,0.9333874957383375,-0.09945195473028835,0.08261594152889151,1.0829361433572473,0.28733419664034965,0.5416126840379538,2245]
["Medium","O00559","Receptor-binding cancer antigen expressed on SiSo cells [OS=Homo sapiens]",8,1,1,1,213,24.4,6.29,2.55,"other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","EBAG9","ENSG00000147654","","Estrogen-dependent gene expression","Estrogen signaling pathway",23.9,31.3,20.7,23.7,20.2,21.4,1.1623277182235836,0.21701689386903572,0.34495584085096687,0.46223649710709835,0.5838749632266095,0.23368014705672963,4613]
["High","O00560-1","Syntenin-1 [OS=Homo sapiens]",40,7,14,7,298,32.4,7.53,38.76,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SDCBP","ENSG00000137575; ENSPPAG00000038846; ENSPTRG00000020277","Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling pathway","Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death","",471,446.8,566.9,389.1,386.7,419,1.242634750585872,0.3134023052773684,0.0643004382876732,1.1917860668072051,0.2527985005791301,0.597225506307932,1986]
["High","O00562","Membrane-associated phosphatidylinositol transfer protein 1 [OS=Homo sapiens]",8,7,7,6,1244,134.8,5.95,14.49,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","PITPNM1","ENSG00000110697","","Synthesis of PI","",384.6,473.6,393.2,390.7,389.6,367.5,1.0902596271127376,0.12467172963206999,0.3043395895532412,0.516641549428989,0.5475307638782735,0.26159147428286433,4340]
["High","O00566","U3 small nucleolar ribonucleoprotein protein Mpp10 [OS=Homo sapiens]",24,16,43,16,681,78.8,4.86,96.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","MPHOSPH10","ENSG00000124383","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1206.7,1111.1,1197.2,1363.4,1325.9,1368.7,0.8661902414982751,-0.20724417579676127,5.534250798751101E-3,2.2569411635821957,0.07943277617030992,1.1000002586217403,544]
["High","O00567","Nucleolar protein 56 [OS=Homo sapiens]",61,28,124,28,594,66,9.19,275.69,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP56","ENSG00000101361","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","Ribosome biogenesis in eukaryotes; Spinocerebellar ataxia",5013.3,6423.5,4973.1,4958,5241.8,5392.4,1.0524428881107222,0.07374194609450084,0.6102244448748219,0.21451039901808674,0.7702283326192385,0.1133805100266115,6186]
["High","O00571","ATP-dependent RNA helicase DDX3X [OS=Homo sapiens]",66,41,252,13,662,73.2,7.18,546.44,"cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","DDX3X","ENSG00000215301","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Hepatitis B infection","Neutrophil degranulation","RIG-I-like receptor signaling pathway; Hepatitis B; Viral carcinogenesis",14020.8,13922.8,14108.6,14661.8,14809,15023.9,0.9451058215922347,-0.08145222085625851,0.002316737398505774,2.63512319057049,0.05243213219574806,1.280402480985129,345]
["High","O00592","Podocalyxin [OS=Homo sapiens]",22,10,69,10,558,58.6,5.49,125.4,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","","PODXL","ENSG00000128567","Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Malignant pleural mesothelioma","","Salmonella infection",3282.1,2897.6,3407.1,3975.4,3680.7,3931,0.8273683665455549,-0.2733982960045348,0.020259444781925203,1.6933724608242189,0.15137391852370527,0.8199489466126562,1045]
["High","O00622","Protein CYR61 [OS=Homo sapiens]",23,8,17,8,381,42,8.21,29.16,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi","signal transduction activity or receptor binding;other molecular function","CCN1","ENSG00000142871","Oncostatin M signaling pathway; VEGFA-VEGFR2 signaling pathway; Hypertrophy model","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",1370.9,1214.2,1326.4,403,410.3,441.8,3.116484742251614,1.6399196495908268,5.1305753128334352E-5,4.289833932903827,0.011445580583600989,1.9413621725954668,35]
["High","O00625","Pirin [OS=Homo sapiens]",27,8,29,8,290,32.1,6.92,33.91,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PIR","ENSG00000087842","","Digestion","",1730.6,1796.3,1740.9,1883.2,1843.9,1873.2,0.9406281806331803,-0.08830353980106037,0.009284269498224144,2.032252261592584,0.10536566314263679,0.9773008951694602,688]
["High","O00629","Importin subunit alpha-3 [OS=Homo sapiens]",43,16,92,12,521,57.9,4.96,245.96,"transport","other membranes;cytosol;nucleus","other molecular function","KPNA4","ENSG00000186432","Leptin signaling pathway","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis",3740.3,3769.6,3698.5,3567.3,3593.8,3562.5,1.0452086985713753,0.06379103640429297,0.002095790888111896,2.678652052160466,0.05129760267829995,1.2899029305590122,319]
["Low","O00635","E3 ubiquitin-protein ligase TRIM38 [OS=Homo sapiens]",2,1,2,1,465,53.4,7.02,0,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM38","ENSG00000112343","","Interferon gamma signaling","",91.3,69.1,72.8,84.8,86,81.6,0.9239302694136291,-0.11414412178205266,0.4117656893143742,0.38534984412458395,0.6371515065728565,0.19575728564750433,5046]
["High","O00743","Serine/threonine-protein phosphatase 6 catalytic subunit [OS=Homo sapiens]",31,8,22,8,305,35.1,5.69,47.21,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","cytosol;mitochondrion;nucleus","other molecular function","PPP6C","ENSG00000119414","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",839.5,953.1,831.3,910,1014.3,973.4,0.9055112675570279,-0.14319550169920828,0.13991055011966827,0.8541495357869373,0.3689367022405842,0.4330481385176011,2961]
["High","O00746","Nucleoside diphosphate kinase, mitochondrial [OS=Homo sapiens]",34,6,16,6,187,20.6,10.29,30.44,"other metabolic processes;transport","other membranes;mitochondrion","kinase activity;other molecular function","NME4","ENSG00000103202","Pyrimidine metabolism","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",972.1,1015.4,964.9,909.8,1007.6,992.8,1.01450072159989,0.02076989126333741,0.7025650690199848,0.15331344678565317,0.8295218598076579,0.08117216483099941,6613]
["High","O00750","Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [OS=Homo sapiens]",2,3,4,3,1634,184.7,7.3,10.18,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2B","ENSG00000133056","Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)","Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection",109.3,89.7,129.5,102.4,120.3,115.9,0.9701712935617247,-0.04368860268594983,0.8038763761047156,0.09481073396750511,0.8900548418357374,0.05058323293615411,7052]
["High","O00754","Lysosomal alpha-mannosidase [OS=Homo sapiens]",9,8,12,8,1011,113.7,7.28,23.14,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MAN2B1","ENSG00000104774","","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","Other glycan degradation; Lysosome",635.4,683.4,689,626.3,597.1,558.6,1.1267115600448934,0.17211823054707484,0.04412586608182708,1.3553067573918365,0.20931638053882495,0.679196783609452,1646]
["High","O00762","Ubiquitin-conjugating enzyme E2 C [OS=Homo sapiens]",23,4,9,4,179,19.6,7.37,12.57,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","UBE2C","ENSG00000175063","Gastric cancer network 1; Gastric cancer network 2","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Ubiquitin mediated proteolysis",380.1,437.9,503.4,512.3,437.1,381.8,0.9926382211538461,-0.010660088763817473,0.9528775516906862,0.020962904232326853,0.9740858763551817,0.011402753610990477,7638]
["High","O00763","Acetyl-CoA carboxylase 2 [OS=Homo sapiens]",3,6,16,1,2458,276.4,6.49,36.48,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","ACACB","ENSG00000076555","AMP-activated protein kinase (AMPK) signaling; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; IL-18 signaling pathway; 7q11.23 copy number variation syndrome","ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP)","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; AMPK signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Glucagon signaling pathway; Insulin resistance; Alcoholic liver disease",55.6,50.8,53.6,47.5,52.8,48.9,1.0723860589812335,0.10082436951948728,0.16317726302196295,0.7873403555822795,0.3995258920274339,0.39845507016660336,3189]
["High","O00764-1","Pyridoxal kinase [OS=Homo sapiens]",40,11,42,11,312,35.1,6.13,76.73,"other metabolic processes","non-structural extracellular;nucleus;other cell component","kinase activity;other molecular function","HEL-S-1a; PDXK","ENSG00000160209","","Neutrophil degranulation; Vitamins B6 activation to pyridoxal phosphate","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors",1058.7,730,1052.9,992.4,961.7,949.1,0.9787820336180769,-0.03094047512922776,0.8602198169168116,0.0653905568080998,0.9218496198855978,0.03533991905536146,7286]
["High","O00767","acyl-CoA desaturase [OS=Homo sapiens]",11,3,19,3,359,41.5,9,30.34,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","SCD","ENSG00000099194","Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Adipogenesis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; AMPK signaling pathway; Alcoholic liver disease",892.2,550.2,952.3,987.5,814.8,1002.5,0.853786366229321,-0.2280529699340344,0.38091812047255935,0.4191683672338869,0.6113481366186523,0.21371140717962225,4865]
["High","O14494","Phospholipid phosphatase 1 [OS=Homo sapiens]",11,2,2,2,284,32.1,7.97,6.23,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","PLPP1","ENSG00000067113","Androgen receptor signaling pathway; Androgen receptor signaling pathway; Sphingolipid pathway; Triacylglyceride synthesis; Androgen receptor signaling pathway","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",85.2,87.2,121.3,115.4,125.2,117.1,0.8210791165781379,-0.2844068526703746,0.15261725017568187,0.8163963757343013,0.3836559849876768,0.4160580224682056,3106]
["High","O14495","Phospholipid phosphatase 3 [OS=Homo sapiens]",10,3,5,3,311,35.1,9.14,8.06,"cell adhesion;cell-cell signaling;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","PLPP3","ENSG00000162407","Triacylglyceride synthesis; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",183.8,255,230.5,257.7,268.4,268.4,0.8424166142227817,-0.24739420527058462,0.1201949648202201,0.920113725316612,0.3456656667831597,0.4613437545828423,2715]
["High","O14497","AT-rich interactive domain-containing protein 1A [OS=Homo sapiens]",28,46,118,45,2285,241.9,6.7,267.26,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ARID1A","ENSG00000117713","Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",5210.5,4695.6,5010.1,5431.1,5127.7,5232.3,0.9445953733432123,-0.082231625745645,0.1695657813550707,0.7706617845560368,0.4068744993301758,0.3905395284982415,3254]
["High","O14524-1","Nuclear envelope integral membrane protein 1 [OS=Homo sapiens]",9,5,9,5,444,50.6,6.93,16.27,"cell organization and biogenesis","other membranes;nucleus","","NEMP1","ENSG00000166881","","","",391,640.7,421.4,427.9,421.3,427.6,1.1380795739348368,0.18660143366177878,0.4966677237105524,0.3039340620097276,0.6941080341385346,0.15857292871125667,5587]
["High","O14530","Thioredoxin domain-containing protein 9 [OS=Homo sapiens]",36,7,21,7,226,26.5,5.88,38,"","cytosol;cytoskeleton;nucleus;other cell component","","TXNDC9","ENSG00000115514","","","",655.2,936.3,753,715.7,637.5,653.4,1.168394298813914,0.22452722365891406,0.25940007335325077,0.5860299054419636,0.5060958952379265,0.29576718508352084,4002]
["High","O14531","dihydropyrimidinase-related protein 4 [OS=Homo sapiens]",21,10,33,10,572,61.8,7.09,65.86,"cell organization and biogenesis;developmental processes;other biological processes","cytosol","cytoskeletal activity;other molecular function","DPYSL4","ENSG00000151640","","CRMPs in Sema3A signaling","",891.8,691.7,950.8,915.3,907.5,949.5,0.914150705190636,-0.12949606996690757,0.3745825930039592,0.4264524083221718,0.6065410381947145,0.2171398097049713,4822]
["High","O14545","TRAF-type zinc finger domain-containing protein 1 [OS=Homo sapiens]",6,3,6,3,582,64.8,5.29,11.48,"other biological processes","","other molecular function","TRAFD1","ENSG00000135148","","","",329.1,347.3,329.5,331.1,285.1,294.4,1.1046562705908192,0.1435975244957413,0.10599823704016924,0.9747013578493181,0.3241810555462755,0.489212367994933,2553]
["High","O14548","Cytochrome c oxidase subunit 7A-related protein, mitochondrial [OS=Homo sapiens]",11,1,1,1,114,12.6,9.42,3.4,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity","COX7A2L","ENSG00000115944","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",87.7,105.3,93.6,107.9,95.5,109.9,0.9147781678902012,-0.12850616010890797,0.2641505790602391,0.578148432933162,0.5095078362901054,0.2928491321062692,4048]
["High","O14561","Acyl carrier protein, mitochondrial [OS=Homo sapiens]",13,2,5,2,156,17.4,4.93,6.75,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","NDUFAB1","ENSG00000004779","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",204.3,322.6,271.7,298.8,264.3,225.9,1.0121673003802283,0.01744777173222728,0.9403965588988126,0.026688968715528293,0.9679167323862284,0.014162002423664609,7586]
["High","O14562","Ubiquitin domain-containing protein UBFD1 [OS=Homo sapiens]",33,7,35,7,309,33.4,5.77,62.32,"","","","UBFD1","ENSG00000103353","","","",1026.1,1421.8,1215.8,1501.6,1249,1250.2,0.915741851629674,-0.12698713615337676,0.4725029564178798,0.3255954697960842,0.6760680014130119,0.17000961892059474,5457]
["High","O14578-4","Isoform 4 of Citron Rho-interacting kinase [OS=Homo sapiens]",19,36,55,36,2069,236.5,6.67,103.88,"","","","CIT","","","","",2590.5,2197,2511.2,2334.2,2420.4,2341.1,1.0286088757980185,0.04069450777689275,0.6123180499578673,0.21302293820993104,0.7701319803593795,0.11343484180142768,6208]
["High","O14579-1","coatomer subunit epsilon [OS=Homo sapiens]",34,12,29,12,308,34.5,5.12,61.56,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","COPE","ENSG00000105669; ENSPTRG00000010723","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",990.4,1154.1,1030.9,1006.3,1058.7,1036.1,1.0239592402695818,0.034158288549533844,0.6557714028775947,0.1832475261284615,0.7996662679475651,0.09709122329399371,6403]
["High","O14617-5","Isoform 5 of AP-3 complex subunit delta-1 [OS=Homo sapiens]",39,34,102,4,1215,136.6,7.64,215.34,"","","","AP3D1","","","","",3599.6,3186.9,3432,3435.4,3664.9,3599.9,0.9549821498663575,-0.06645432774940467,0.30907481309419926,0.5099363847131138,0.5521061863737149,0.25797738654413094,4371]
["High","O14618","copper chaperone for superoxide dismutase [OS=Homo sapiens]",37,9,26,9,274,29,5.58,58.72,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CCS","ENSG00000173992","Amyotrophic lateral sclerosis (ALS); Copper homeostasis","Detoxification of Reactive Oxygen Species","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",1513.7,1383.7,1518.6,1418.4,1392,1396.4,1.049729010174004,0.07001694109446167,0.19553135124048865,0.7087835984771819,0.43670159910919204,0.3598152177809119,3496]
["High","O14628-1","Zinc finger protein 195 [OS=Homo sapiens]",17,8,12,3,629,72.3,8.09,18.84,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF195","ENSG00000005801","","Generic Transcription Pathway","Herpes simplex virus 1 infection",222.2,200.5,223.8,200.6,216.7,219,1.016030174446016,0.02294324844590551,0.7381186617198706,0.13187381434558174,0.8507869073972172,0.07017920199555787,6774]
["High","O14639-1","Actin-binding LIM protein 1 [OS=Homo sapiens]",8,5,5,5,778,87.6,8.59,7.43,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ABLIM1","ENSG00000099204","Male infertility","DCC mediated attractive signaling","Axon guidance",154.6,191.5,150.3,213.4,149.2,144,0.9798657718120805,-0.029343961582144463,0.9017669599787996,0.044905680940909555,0.9447197670085157,0.024696997512524792,7453]
["High","O14641","Segment polarity protein dishevelled homolog DVL-2 [OS=Homo sapiens]",18,12,21,10,736,78.9,6.02,43.31,"cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","DVL2","ENSG00000004975","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)","RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; Degradation of DVL; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",1218.2,1255.8,1094.5,1051.7,1136.3,1099.4,1.085508304435116,0.11837076300651744,0.16087757163475172,0.7935044978165038,0.39688217356212996,0.40133840751124233,3165]
["High","O14646","Chromodomain-helicase-DNA-binding protein 1 [OS=Homo sapiens]",21,35,65,30,1710,196.6,7.14,121.56,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD1","ENSG00000153922","","Estrogen-dependent gene expression","",2612.2,4087,2476.9,2951.3,2811.6,3032.3,1.0433077132981627,0.06116472926276373,0.8189937272948279,0.08671942450536323,0.8995221582104397,0.04598813407496532,7109]
["High","O14647","Chromodomain-helicase-DNA-binding protein 2 [OS=Homo sapiens]",13,23,44,18,1828,211.2,8.1,79.25,"cell organization and biogenesis;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CHD2","ENSG00000173575","Prion disease pathway; Male infertility","","",1416.9,1418.4,1422.1,1670.5,1573.7,1733.9,0.8552258893955523,-0.2256225679079671,6.722836708179347E-3,2.172447437250095,0.08734094678446647,1.058782104594199,601]
["High","O14653-1","Golgi SNAP receptor complex member 2 [OS=Homo sapiens]",24,4,4,4,212,24.8,8.06,11.17,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","GOSR2","ENSG00000108433","","COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER","SNARE interactions in vesicular transport",258,222.8,272.9,224.8,270.8,251.3,1.0091042977640916,0.01307529445489744,0.9150478790971499,0.038556181251937695,0.9528799466511798,0.02096181267883419,7498]
["High","O14656","Torsin-1A [OS=Homo sapiens]",19,5,10,5,332,37.8,6.99,14.35,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TOR1A","ENSG00000136827","","Cargo recognition for clathrin-mediated endocytosis","",302.5,258.7,311.4,299.3,303.9,308.5,0.9571130854447735,-0.06323870186695078,0.47383612465438274,0.32437183230046496,0.6769830670267923,0.16942219392755117,5465]
["Low","O14657","Torsin-1B [OS=Homo sapiens]",2,1,2,1,336,38,8.54,4.48,"cell organization and biogenesis;stress response;other biological processes","other membranes;ER/Golgi;nucleus","cytoskeletal activity;other molecular function","TOR1B","ENSG00000136816","","Cargo recognition for clathrin-mediated endocytosis","",162.9,91.2,171.6,146.2,131.4,150.4,0.9946261682242992,-0.007773706506801589,0.9779882332142618,0.009666370448449719,0.9870905021893687,0.005643026864759567,7736]
["High","O14662-2","Isoform A of Syntaxin-16 [OS=Homo sapiens]",27,6,11,6,304,34.8,6.2,24.64,"","","","STX16","","","","",662.1,646.6,637.1,508,468.4,478.1,1.3377793056033003,0.4198401331892941,3.0267761262574625E-4,3.5190197001952646,0.023633067993818268,1.6264798955366293,100]
["Medium","O14668-1","Transmembrane gamma-carboxyglutamic acid protein 1 [OS=Homo sapiens]",3,1,2,1,218,24.9,5.19,4.45,"","non-structural extracellular;plasma membrane;other membranes","other molecular function","PRRG1","ENSG00000130962; ENSNLEG00000000909","","","",95.1,111.9,98.4,84.7,84.7,83.4,1.2080696202531644,0.2727035986197484,0.0272846258576783,1.564081997133165,0.17180512798125175,0.7649638776367647,1240]
["High","O14672","Disintegrin and metalloproteinase domain-containing protein 10 [OS=Homo sapiens]",28,17,39,17,748,84.1,7.77,86.88,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM10","ENSG00000137845","Alzheimer's disease and miRNA effects; Copper homeostasis; Canonical and non-canonical Notch signaling; VEGFA-VEGFR2 signaling pathway; 3q29 copy number variation syndrome; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Hypertrophy model","Amyloid fiber formation; Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus","Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection",1091.8,1142.1,1228.6,1402.5,1461.3,1422.4,0.8078251131538423,-0.30788509856244817,3.2277273439439242E-3,2.4911031585911774,0.061618814429129976,1.2102866619398838,409]
["High","O14681","Etoposide-induced protein 2.4 homolog [OS=Homo sapiens]",8,3,3,3,340,38.9,9.72,7.6,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EI24","ENSG00000149547","miRNA regulation of p53 pathway in prostate cancer","","p53 signaling pathway",264.4,251.5,278.3,250.2,254.4,259.3,1.0396648776017803,0.05611856939014552,0.28414768799484563,0.5464558732992284,0.5300107854428463,0.2757152926432607,4186]
["High","O14682","Ectoderm-neural cortex protein 1 [OS=Homo sapiens]",3,2,4,2,589,66.1,6.84,7.6,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity","ENC1","ENSG00000171617","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","",418.2,427.3,452.2,226.9,189.6,188,2.1467328370554175,1.10214265759719,1.427973454566525E-4,3.845279865838859,0.016893358686750647,1.772283996722092,66]
["High","O14683","Tumor protein p53-inducible protein 11 [OS=Homo sapiens]",18,3,12,3,189,21,9.55,34.84,"other biological processes","other membranes","","TP53I11","ENSG00000175274","","","",349.9,390.1,397,363.4,387.5,368.9,1.015359885693874,0.0219911690666177,0.7442181233694485,0.1282997581474497,0.8537841767952769,0.06865189824860486,6806]
["High","O14686-1","Histone-lysine N-methyltransferase 2D [OS=Homo sapiens]",5,20,31,20,5537,593,5.58,54.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KMT2D","ENSG00000167548","Histone modifications; 16p11.2 proximal deletion syndrome","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Lysine degradation; Metabolic pathways; Cushing syndrome",966.6,865.1,915.5,1043.9,1007.9,1040.7,0.8883427647534357,-0.1708116507489604,0.021646837356269547,1.6646055459181128,0.15506284961261707,0.8094922392001012,1090]
["High","O14717-1","tRNA (cytosine(38)-C(5))-methyltransferase [OS=Homo sapiens]",7,2,2,2,391,44.6,6.09,4.6,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT2; TRDMT1","ENSG00000107614","","tRNA modification in the nucleus and cytosol","",17.1,11.5,12.6,14.5,12.1,16.5,0.9559164733178654,-0.06504353190587973,0.7813653639924598,0.10714584389231628,0.8765662014444148,0.057215278844242955,6960]
["High","O14727","apoptotic protease-activating factor 1 [OS=Homo sapiens]",4,5,6,5,1248,141.7,6.4,12.17,"stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;other cell component","enzyme regulator activity;other molecular function","APAF1","ENSG00000120868","miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkinson's disease pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; p53 transcriptional gene network; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response","Neutrophil degranulation; Transcriptional Regulation by E2F6; Formation of apoptosome; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of the apoptosome activity","Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Legionellosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Small cell lung cancer; Lipid and atherosclerosis",235.5,196.2,242.3,274.7,288.6,287.1,0.7925682031984949,-0.33539300546188383,0.017354463982628663,1.7605887955898931,0.14114964039204647,0.850320223970826,960]
["High","O14730","serine/threonine-protein kinase RIO3 [OS=Homo sapiens]",8,4,5,4,519,59.1,5.76,6.55,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;other cell component","kinase activity;other molecular function","RIOK3","ENSG00000101782","","Major pathway of rRNA processing in the nucleolus and cytosol","",156.3,134.5,141.2,156.3,170.7,169.8,0.8695652173913043,-0.2016338611696506,0.05321233845818086,1.2739876552423786,0.23069513530342928,0.6369615634032765,1801]
["High","O14732-1","inositol monophosphatase 2 [OS=Homo sapiens]",17,4,6,4,288,31.3,6.61,13.79,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA2","ENSG00000141401","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",421.4,452.6,421,423.4,430.8,440.3,1.0003862495171882,5.5713267380525324E-4,0.9891814156823038,4.724051573217888E-3,0.9946591749706926,2.3257069791598256E-3,7765]
["High","O14733","dual specificity mitogen-activated protein kinase kinase 7 [OS=Homo sapiens]",15,5,15,5,419,47.5,9.16,22,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAP2K7","ENSG00000076984","MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; MAPK signaling pathway; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; Alzheimer's disease; ErbB signaling pathway; Toll-like receptor signaling pathway","FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Uptake and function of anthrax toxins","MAPK signaling pathway; ErbB signaling pathway; Protein processing in endoplasmic reticulum; Osteoclast differentiation; Tight junction; Toll-like receptor signaling pathway; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Relaxin signaling pathway; Alcoholic liver disease; Alzheimer disease; Huntington disease; Pathways of neurodegeneration; Salmonella infection; Yersinia infection; Hepatitis B; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Chemical carcinogenesis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",716.3,635.1,773.1,719.2,743.3,785.6,0.9450202393131978,-0.08158286730592411,0.40691921839812256,0.3904917983571956,0.6329133978590719,0.19865571084357958,5020]
["High","O14734","Acyl-coenzyme A thioesterase 8 [OS=Homo sapiens]",22,4,5,4,319,35.9,7.56,17.22,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOT8","ENSG00000101473","","Peroxisomal protein import; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids","Primary bile acid biosynthesis; Metabolic pathways; Peroxisome",66.7,62.4,71.2,69.5,96.1,78.4,0.8209016393442623,-0.28471872663754094,0.15107019522627776,0.8208212095560735,0.3821043357067628,0.4178180343795336,3087]
["High","O14735","CDP-diacylglycerol--inositol 3-phosphatidyltransferase [OS=Homo sapiens]",19,4,6,4,213,23.5,8.03,11.57,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","CDIPT","ENSG00000103502","Glycerolipids and glycerophospholipids; 16p11.2 proximal deletion syndrome","Synthesis of PI","Inositol phosphate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system",505.2,481.8,488.7,483.9,454.7,449.6,1.0630312635066994,0.08818402682463823,0.08395168598485142,1.0759705775894817,0.28812956666800876,0.5404121739239774,2275]
["High","O14744","Protein arginine N-methyltransferase 5 [OS=Homo sapiens]",39,22,81,22,637,72.6,6.29,162.25,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","PRMT5","ENSG00000100462","Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis","RMTs methylate histone arginines; snRNP Assembly; Regulation of TP53 Activity through Methylation","",3414.4,3156.7,3389.1,3411.4,3594.4,3567.6,{"$f":"AVERAGE(T194:V194)/AVERAGE(W194:Y194)","v":0.9420054098019559},{"$f":"LOG(Z194,2)","v":-0.0861927498348205},{"$f":"TTEST(T194:V194,W194:Y194,2,2)","v":0.11020154742534893},{"$f":"-LOG10(AB194)","v":0.9578123071759591},{"$f":"AB194*7808/AF194","v":0.33158138046131963},{"$f":"-LOG10(AD194)","v":0.4794098647018003},2595]
["High","O14745","Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [OS=Homo sapiens]",44,13,23,13,358,38.8,5.77,51.87,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function","SLC9A3R1","ENSG00000109062","","","Tight junction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human papillomavirus infection",885.3,869.4,856.1,1068.7,764.2,723.6,1.0212399765304125,0.03032191838972739,0.8764221070829878,0.057286676224222746,0.9304016059964608,0.03132954862913624,7355]
["High","O14757","Serine/threonine-protein kinase Chk1 [OS=Homo sapiens]",22,9,14,9,476,54.4,8.25,28.33,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CHEK1","ENSG00000149554","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; DNA damage response","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis",537.2,477.3,613.8,791,950.8,885.6,0.6197381441729466,-0.6902693276177221,5.4491763096225065E-3,2.263669140149218,0.07864541335588268,1.1043266005971522,541]
["High","O14763","Tumor necrosis factor receptor superfamily member 10B [OS=Homo sapiens]",11,3,7,3,440,47.8,5.55,2.63,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TNFRSF10B","ENSG00000120889","miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer; miRNA regulation of p53 pathway in prostate cancer; Unfolded protein response; DNA damage response","Cell surface interactions at the vascular wall; Regulation by c-FLIP; RIPK1-mediated regulated necrosis; CASP8 activity is inhibited; TP53 Regulates Transcription of Death Receptors and Ligands; Dimerization of procaspase-8; TRAIL  signaling","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; p53 signaling pathway; Apoptosis; Necroptosis; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Salmonella infection; Influenza A; Lipid and atherosclerosis",38.7,54.7,41.4,45.2,53.9,50.2,0.9028801071667782,-0.1473936689526829,0.4330151442865727,0.36349691435084697,0.6510653276698555,0.18637543228726788,5193]
["High","O14772","fucose-1-phosphate guanylyltransferase [OS=Homo sapiens]",7,4,5,3,594,66.6,6.48,10.02,"","","other molecular function","FPGT","ENSG00000254685","","","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",134.2,143.4,125.5,127.6,134.8,121.8,1.0491931285788654,0.06928026418555272,0.3800611755576881,0.4201464926758861,0.6104747292232933,0.2143323090917929,4861]
["High","O14773","Tripeptidyl-peptidase 1 [OS=Homo sapiens]",20,7,15,7,563,61.2,6.48,42.56,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TPP1","ENSG00000166340","VEGFA-VEGFR2 signaling pathway","XBP1(S) activates chaperone genes","Lysosome",1025,866.4,1081,1006.9,1079.6,1056.7,0.9456604734029016,-0.08060579849116732,0.44804158438758923,0.34868167566271335,0.6589392900543034,0.1811545963452349,5309]
["High","O14775","Guanine nucleotide-binding protein subunit beta-5 [OS=Homo sapiens]",8,2,2,2,395,43.5,6.46,6.36,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","GNB5","ENSG00000069966","Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells","G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits","Ras signaling pathway; Chemokine signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Relaxin signaling pathway; Morphine addiction; Alcoholism; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",34.6,41.8,34.3,34.8,42,35.7,0.984,-0.02326977932284719,0.8660752322025977,0.06244438106425776,0.926217697991766,0.033286924846410035,7301]
["High","O14776-1","Transcription elongation regulator 1 [OS=Homo sapiens]",26,34,100,34,1098,123.8,8.65,216.66,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","TCERG1","ENSG00000113649; ENSGGOG00000003329; ENSPTRG00000017375","","","Spliceosome",7261.8,6564.4,6619.8,8191.5,7588,7916,0.8628642569264205,-0.21279447784978223,0.018822305668173427,1.725327178059027,0.1465249876940161,0.8340883064208096,1003]
["High","O14777","Kinetochore protein NDC80 homolog [OS=Homo sapiens]",36,20,40,20,642,73.9,5.6,78.95,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NDC80","ENSG00000080986","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",2213.8,1933.8,2173.2,2582.1,2464.5,2445.5,0.8436619906301304,-0.2452629894559852,0.01592988887278563,1.7977872538350472,0.1360837771539499,0.8661936449102433,914]
["High","O14782","Kinesin-like protein KIF3C [OS=Homo sapiens]",6,5,5,2,793,89.4,8.22,13.05,"transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3C","ENSG00000084731","","Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",50,54.1,69.9,64.6,71,64.1,0.871306960440661,-0.19874702670788189,0.25548746779557285,0.5926303980760936,0.5026067393670529,0.2987716923246216,3969]
["High","O14787-2","Isoform 2 of Transportin-2 [OS=Homo sapiens]",34,24,72,12,887,100.3,4.98,136.86,"","","","TNPO2","","","","",1287.6,1438.6,1329.5,1127,1119.9,1157.6,1.191276252019386,0.2525080069921907,0.009509221211319804,2.0218550495689964,0.10622031361657372,0.9737924206560425,699]
["High","O14795","Protein unc-13 homolog B [OS=Homo sapiens]",9,12,19,11,1591,180.6,5.99,27.15,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","UNC13B","ENSG00000198722","Synaptic vesicle pathway; 16p11.2 proximal deletion syndrome; Monoamine transport","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle","Synaptic vesicle cycle",604.6,538.7,609.3,613.9,585.2,597,0.9757808585268083,-0.03537091207362307,0.5823053135118674,0.23484924695473447,0.7525057742304967,0.12349016323336069,6042]
["Medium","O14798","Tumor necrosis factor receptor superfamily member 10C [OS=Homo sapiens]",4,1,1,1,259,27.4,4.82,2.91,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TNFRSF10C","ENSG00000173535","Apoptosis modulation and signaling; VEGFA-VEGFR2 signaling pathway","TP53 Regulates Transcription of Death Receptors and Ligands","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor",82.2,82.3,91.2,85.1,67.6,81.5,1.091801878736123,0.1267110847404338,0.3061083862174494,0.514124772205762,0.5489421864000563,0.2604733922522021,4354]
["High","O14802","DNA-directed RNA polymerase III subunit RPC1 [OS=Homo sapiens]",28,29,60,28,1390,155.5,8.48,110.91,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3A","ENSG00000148606","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",2151.7,1788.9,2177.7,2155.8,2243.5,2177,0.9303559752444384,-0.10414526527234053,0.2996868973004164,0.5233322445569307,0.5435436223279098,0.26476559568796887,4305]
["High","O14818-1","Proteasome subunit alpha type-7 [OS=Homo sapiens]",66,16,112,16,248,27.9,8.46,245.84,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","HEL-S-276; PSMA7","ENSG00000101182","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",4473.8,3900.8,4696.8,4898.8,5158.8,4812.4,0.8790450571620714,-0.18599097948648521,0.08153862275900006,1.0886366283415256,0.2851113150480396,0.5449855467543282,2233]
["Low","O14827","Ras-specific guanine nucleotide-releasing factor 2 [OS=Homo sapiens]",1,1,1,1,1237,140.7,7.53,0,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","RASGRF2","ENSG00000113319","MAPK signaling pathway; Ras signaling","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor","MAPK signaling pathway; Ras signaling pathway",90,66.2,99.3,93.3,103.9,93.2,0.8798209366391185,-0.1847181621707669,0.32904439306619954,0.48274550520179593,0.5697890044490765,0.2442859358497311,4509]
["High","O14828","Secretory carrier-associated membrane protein 3 [OS=Homo sapiens]",41,9,31,9,347,38.3,7.64,88.4,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCAMP3","ENSG00000116521; ENSG00000263290","","","",691.5,812.2,670.7,671.9,644.6,688.5,1.0844887780548629,0.11701512453774633,0.2862870257510034,0.5431983333350987,0.5318413269245383,0.27421791868190026,4203]
["High","O14832","Phytanoyl-CoA dioxygenase, peroxisomal [OS=Homo sapiens]",10,4,8,4,338,38.5,8.47,16,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","PHYH","ENSG00000107537","","TYSND1 cleaves peroxisomal proteins; Alpha-oxidation of phytanate","Peroxisome",710.1,618.4,680.9,713.8,677.9,671.2,0.9740656357554901,-0.03790910575373206,0.5854950800267298,0.23247674999592186,0.7550033996447079,0.1220510928163575,6055]
["High","O14841","5-oxoprolinase [OS=Homo sapiens]",10,9,11,9,1288,137.4,6.58,25.59,"other metabolic processes","cytosol","other molecular function","OPLAH","ENSG00000178814","Glutathione metabolism","Glutathione synthesis and recycling; Defective OPLAH causes OPLAHD","Glutathione metabolism; Metabolic pathways",144.4,157.6,148.5,134.7,151.1,147.1,1.0406560406560408,0.0574933054885468,0.40390402694392186,0.39372181687010593,0.6307365284756283,0.20015201654748935,5000]
["High","O14867","Transcription regulator protein BACH1 [OS=Homo sapiens]",29,17,28,17,736,81.9,5.05,55.25,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH1","ENSG00000156273","Integrated cancer pathway; Ferroptosis","Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity","",1236.4,1262.4,1199,1001.9,905.7,922.1,1.306781637629431,0.38601808785993247,1.1614447187712736E-3,2.9350014564655034,0.03892085993204337,1.4098175728328868,233]
["Medium","O14874","[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial [OS=Homo sapiens]",4,1,1,1,412,46.3,8.82,2.17,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","BCKDK","ENSG00000103507","Thiamine metabolic pathways","Branched-chain amino acid catabolism","",12.6,16.7,17.5,12.9,15.3,16.6,1.044642857142857,0.0630097975258002,0.7387929899335931,0.1314772340325567,0.8506851003394035,0.0702311737509309,6781]
["High","O14880","Microsomal glutathione S-transferase 3 [OS=Homo sapiens]",28,3,20,3,152,16.5,9.38,43.62,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","MGST3","ENSG00000143198","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II","Aflatoxin activation and detoxification; Glutathione conjugation","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",498.4,466.3,483.8,440.3,514.9,481.5,1.008213266513538,0.011800843200608353,0.8751176324385188,0.057933565623117696,0.9306617371397378,0.03120814113245028,7342]
["High","O14893","Gem-associated protein 2 [OS=Homo sapiens]",29,7,13,7,280,31.6,5.58,27.35,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","GEMIN2","ENSG00000092208","","snRNP Assembly","",408.3,464.2,375.7,444.1,422.3,454.6,0.9448902346707041,-0.081781349779984,0.427948767954713,0.36860821959975515,0.6478138775088017,0.1885497527430384,5158]
["Medium","O14896-1","Interferon regulatory factor 6 [OS=Homo sapiens]",3,1,1,1,467,53.1,5.33,0,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IRF6","ENSCANG00000037044; ENSCATG00000039683; ENSG00000117595; ENSGGOG00000006214; ENSMFAG00000033961; ENSMMUG00000022065; ENSMNEG00000040867; ENSNLEG00000001962; ENSPPAG00000032756; ENSPPYG00000000253; ENSPTRG00000001941","Apoptosis; Primary focal segmental glomerulosclerosis (FSGS); Hypothetical craniofacial development pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway","Interferon gamma signaling; Interferon alpha/beta signaling","",15.7,13.2,12.8,14,8.8,13.1,1.1615598885793872,0.21606353962161226,0.35344126394642245,0.4516827483830772,0.5903036125975757,0.2289245589329784,4675]
["High","O14907","Tax1-binding protein 3 [OS=Homo sapiens]",26,3,6,3,124,13.7,8.48,13.43,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TAX1BP3","ENSG00000213977","","RHO GTPases Activate Rhotekin and Rhophilins","",214.2,222.5,265.1,190.8,192.8,205.6,1.1911065852002714,0.25230251736631715,0.0844235257213097,1.0735365146628255,0.28873363505562255,0.5395026214944254,2283]
["High","O14908-1","PDZ domain-containing protein GIPC1 [OS=Homo sapiens]",32,8,18,8,333,36,6.28,43.29,"cell-cell signaling;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GIPC1","ENSG00000123159","VEGFA-VEGFR2 signaling pathway","","",1314.5,1369.6,1279.8,1317.1,1243,1299,1.0271565909149802,0.0386561385356634,0.3668734611669325,0.4354837030317826,0.6006600932672277,0.22137122080701424,4769]
["High","O14910","Protein lin-7 homolog A [OS=Homo sapiens]",15,4,11,2,233,26,8.72,19.9,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","LIN7A","ENSG00000111052","","Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle","",399.2,434.7,449.5,500.7,440.3,421.6,0.941875825627477,-0.08639122354184345,0.40143334903053957,0.3963865513843473,0.6283864453148462,0.20177319153221693,4988]
["High","O14920-1","Inhibitor of nuclear factor kappa-B kinase subunit beta [OS=Homo sapiens]",15,6,9,6,756,86.5,5.78,13.02,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","IKBKB","ENSG00000104365","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",151,120.7,180.1,170.1,187.2,181.4,0.8386857248932617,-0.25379779444601097,0.1803098906332704,0.7439804500405515,0.42050765414115154,0.37622609470313845,3348]
["High","O14924","Regulator of G-protein signaling 12 [OS=Homo sapiens]",4,5,5,4,1447,156.3,7.44,4.95,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","RGS12","ENSG00000159788","","G alpha (i) signalling events","",14.5,11.5,18,18.9,19.1,15,0.830188679245283,-0.26848883592590206,0.26282292142699565,0.5803367615811901,0.5082024196389257,0.2939632715301752,4038]
["High","O14929","histone acetyltransferase type B catalytic subunit [OS=Homo sapiens]",35,10,88,10,419,49.5,5.69,190.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","HAT1","ENSG00000128708","Ethanol effects on histone modifications","HATs acetylate histones","Neutrophil extracellular trap formation; Alcoholism",2799.4,2721.1,2952.5,2873.4,3083.5,2958.7,0.950356678182063,-0.07345902221291674,0.18149370184378652,0.7411384411620188,0.42138056021299,0.37532550381801894,3363]
["Medium","O14933","Ubiquitin/ISG15-conjugating enzyme E2 L6 [OS=Homo sapiens]",5,1,2,1,153,17.8,7.88,4.52,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UBE2L6","ENSG00000156587","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome","Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration",69.1,109.9,88.4,140.9,104.2,100.4,0.7739507959479015,-0.3696862451822682,0.21067679657743324,0.676383293880728,0.45265944625112786,0.3442284121941082,3634]
["High","O14936","peripheral plasma membrane protein CASK [OS=Homo sapiens]",29,23,54,23,926,105.1,6.43,119,"cell adhesion;protein metabolism;other metabolic processes;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CASK","ENSG00000147044","Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions","",3088.6,2743.9,3237.7,3035,3239,3119,0.9656339827531141,-0.05045164633512333,0.5326435558824435,0.2735633228652227,0.7175432857712419,0.14415189500572434,5796]
["High","O14939-1","Phospholipase D2 [OS=Homo sapiens]",5,5,6,5,933,105.9,7.64,8.76,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","PLD2","ENSG00000129219","Ras signaling; EGF/EGFR signaling pathway","Role of phospholipids in phagocytosis; RAC1 GTPase cycle; RAC2 GTPase cycle; Synthesis of PG; Synthesis of PA","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways; Ras signaling pathway; cAMP signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Endocytosis; Fc gamma R-mediated phagocytosis; Glutamatergic synapse; GnRH signaling pathway; Parathyroid hormone synthesis, secretion and action; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Choline metabolism in cancer",376.6,400.6,405.5,312.2,324.9,313.7,1.2438998737904923,0.31487036215702735,1.3900119161581097E-3,2.856981476652718,0.04272918520221465,1.3692753886140205,254]
["High","O14949","Cytochrome b-c1 complex subunit 8 [OS=Homo sapiens]",29,3,6,3,82,9.9,10.08,11.63,"other metabolic processes;transport;developmental processes","other membranes;mitochondrion","","UQCRQ","ENSG00000164405","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly","Respiratory electron transport","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",442.2,498.5,526,497.1,553.4,533.5,0.9259469696969698,-0.11099852423767838,0.25788442388877664,0.5885748882747798,0.5049051107631816,0.2967902332557625,3988]
["High","O14950","Myosin regulatory light chain 12B [OS=Homo sapiens]",40,6,23,6,172,19.8,4.84,56.04,"other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL12B","ENSG00000118680","Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion","RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Salmonella infection",440.2,831.4,514.3,599.7,449.7,473.8,1.1724658613445378,0.22954591644132502,0.533511997194707,0.2728558100597992,0.7179699541703329,0.14389372986780916,5802]
["High","O14964","Hepatocyte growth factor-regulated tyrosine kinase substrate [OS=Homo sapiens]",24,16,34,16,777,86.1,6.16,73.13,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","HGS","ENSG00000185359","TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway","Lysosome Vesicle Biogenesis; Ub-specific processing proteases; Cargo recognition for clathrin-mediated endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle","Endocytosis; Phagosome",1733.7,1575.3,1714.4,1599.1,1499.7,1559.4,1.078399381735434,0.10889157451123051,0.10232487785375581,0.9900187651041099,0.318307827204034,0.49715268192651263,2510]
["High","O14965","Aurora kinase A [OS=Homo sapiens]",16,5,11,5,403,45.8,9.39,24.71,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AURKA","ENSG00000087586","Gastric cancer network 1; EGF/EGFR signaling pathway","Regulation of TP53 Activity through Phosphorylation; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA","Oocyte meiosis; Progesterone-mediated oocyte maturation",280.5,235.2,287.5,250.8,257.3,258.9,1.0471968709256845,0.06653269156047621,0.507005914158881,0.2949869746477557,0.7002834207947183,0.15472615544923904,5653]
["High","O14966-1","Ras-related protein Rab-7L1 [OS=Homo sapiens]",23,4,5,4,203,23.1,7.18,10.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB29; RAB7L1","ENSG00000117280; ENSNLEG00000029152; ENSPPAG00000013675; ENSPPYG00000000298; ENSPTRG00000001905","","RAB geranylgeranylation","",362.6,449,401.4,455.2,493.6,480.5,0.8486671797383334,-0.23672920928346566,0.058153525465971884,1.2354239517178747,0.2410099399354079,0.6179650455160979,1884]
["High","O14967","calmegin [OS=Homo sapiens]",28,13,34,12,610,70,4.69,44.08,"cell organization and biogenesis;stress response;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","CLGN","ENSG00000153132","","","",1143.5,1094.9,1191.5,1226.7,1270.6,1217.4,0.9233316283952944,-0.1150791883902934,0.04263254969903094,1.370258692989589,0.2059869728032386,0.6861602447695209,1616]
["High","O14972","Down syndrome critical region protein 3 [OS=Homo sapiens]",8,2,3,2,297,33,7.68,5.94,"transport","other cytoplasmic organelle","","VPS26C","ENSG00000157538","","","",64.8,64.3,70.4,76.3,77.2,79.5,0.8562231759656652,-0.2239412084319345,0.006820345364189485,2.1661936332666687,0.08831385838074876,1.0539711407481844,603]
["High","O14974","Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",49,45,141,44,1030,115.2,5.4,267.69,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12A","ENSG00000058272","Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton","Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","cGMP-PKG signaling pathway; cAMP signaling pathway; Vascular smooth muscle contraction; Focal adhesion; Platelet activation; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer",7291.4,6948,6905.8,6996.8,6526,6694.9,1.0458756436192052,0.06471132290471103,0.16828839989120534,0.7739458188837413,0.4051791015573639,0.3923529628980787,3243]
["Medium","O14975","very long-chain acyl-CoA synthetase [OS=Homo sapiens]",2,1,1,1,620,70.3,8.51,0,"other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC27A2","ENSG00000140284","PPAR signaling pathway","Peroxisomal protein import; Neutrophil degranulation; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Alpha-oxidation of phytanate; Synthesis of bile acids and bile salts via 24-hydroxycholesterol","PPAR signaling pathway; Peroxisome; Insulin resistance",18.6,18.8,22.6,19.3,27.1,21,0.8902077151335313,-0.16778609068597744,0.4129478747362348,0.3841047646707389,0.638095587955773,0.19511425825033402,5053]
["High","O14976","Cyclin-G-associated kinase [OS=Homo sapiens]",20,15,36,15,1311,143.1,5.73,66.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","GAK","ENSG00000178950","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","",1028.3,862.4,1027.3,1031.2,1100.1,1056.3,0.9154222612623916,-0.12749071902662074,0.2005019285339524,0.6978814457489078,0.4417378831808974,0.3548353543052855,3544]
["High","O14979-1","Heterogeneous nuclear ribonucleoprotein D-like [OS=Homo sapiens]",29,14,153,12,420,46.4,9.57,280.03,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPDL; HNRPDL","ENSG00000152795; ENSPPAG00000043177; ENSPTRG00000016217","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",4806.5,4273.4,4494.2,5138.9,5004.2,5184.7,0.8855869726901447,-0.17529409518609967,0.023428582607767385,1.6302539847383046,0.15962510733110624,0.7968987977110404,1146]
["High","O14980","Exportin-1 [OS=Homo sapiens]",44,39,187,39,1071,123.3,6.06,400.66,"transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPO1","ENSG00000082898","eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MAPK6/MAPK4 signaling; Deactivation of the beta-catenin transactivating complex; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Heme signaling; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Influenza A; Human T-cell leukemia virus 1 infection",7560,6627.9,7842.9,8362.6,9213.2,8926.3,0.8312850679757451,-0.2665847976387324,0.02839078172997589,1.546822649166964,0.1739993906967439,0.7594522725076603,1274]
["High","O14981","TATA-binding protein-associated factor 172 [OS=Homo sapiens]",10,13,29,13,1849,206.8,6.52,67.1,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BTAF1","ENSG00000095564","","","",903.4,1051.2,910.7,869.1,845.2,868.7,1.1092915214866435,0.14963855516107227,0.12572566814508185,0.900576047725718,0.3523567899773148,0.4530173551550272,2786]
["High","O14994","Synapsin-3 [OS=Homo sapiens]",5,2,2,2,580,63.3,9.39,2.45,"cell-cell signaling;transport;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","SYN3","ENSG00000185666","Synaptic vesicle pathway","Serotonin Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle","",103.9,105.3,82,132.8,147.2,123.7,0.721327718602923,-0.47127323128181375,0.02116273806958517,1.674428143272821,0.1532826148861976,0.8145070994649054,1078]
["High","O15013","rho guanine nucleotide exchange factor 10 [OS=Homo sapiens]",12,11,18,11,1369,151.5,5.68,26.01,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity","ARHGEF10","ENSG00000104728; ENSG00000274726","","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events","",659.9,607.3,687.2,626.4,654.6,680.4,0.9964311206281226,-0.005158014221166171,0.9379421077575752,0.02782396658611446,0.9662820922774966,0.014896068993329955,7579]
["High","O15014","zinc finger protein 609 [OS=Homo sapiens]",10,15,23,14,1411,151.1,8.03,37.1,"developmental processes;other biological processes","nucleus","other molecular function","ZNF609","ENSG00000180357","","","",1137,1294.5,1136.3,1305.5,1080.6,1149.2,1.0091929963510875,0.013202099373130575,0.9045513180780149,0.043566789195675394,0.9468744726576136,0.02370759168896969,7459]
["High","O15015","Zinc finger protein 646 [OS=Homo sapiens]",6,10,10,9,1829,200.6,7.33,23.91,"","","","","","","","",514.4,449.1,486.2,517.1,493.9,510.6,0.9527471083070452,-0.06983477058244746,0.29967362620422533,0.5233514769341712,0.5436458348983717,0.26468393493386844,4304]
["High","O15020","Spectrin beta chain, non-erythrocytic 2 [OS=Homo sapiens]",26,51,98,39,2390,271.2,6.11,197.61,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTBN2","ENSG00000173898","","MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","Spinocerebellar ataxia; Pathways of neurodegeneration",2056,1677.4,1999.7,1769.7,1840,1770.8,1.065532943035034,0.09157519754912558,0.3835746397090324,0.4161501142190803,0.6138452114876255,0.2119411276727112,4879]
["High","O15027-5","Isoform 5 of Protein transport protein Sec16A [OS=Homo sapiens]",16,27,61,27,2201,235.6,5.67,122.53,"","","","","","","","",2562.6,2446.9,2391.7,2402.1,2268.4,2306.2,1.0608453853541073,0.08521440362558944,0.09216235429022605,1.0354464397130232,0.3035021772661683,0.517838189032576,2371]
["High","O15031","Plexin-B2 [OS=Homo sapiens]",15,19,27,19,1838,205,6.24,58.63,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PLXNB2","ENSG00000196576","","","Axon guidance",897.1,1058.4,867.3,884.6,871.9,852.3,1.082030052131248,0.11374056890468379,0.300927543188537,0.521538060490698,0.5446551361187058,0.2638783965985888,4314]
["High","O15037","protein KHNYN [OS=Homo sapiens]",8,3,4,3,678,74.5,7.02,11.83,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHNYN","ENSG00000100441","","","",172.8,200.7,178.6,161.1,161.8,161.5,1.1397605284888521,0.18873073609761032,0.056733249632158846,1.2461623397052595,0.23892837817038634,0.6217322648551024,1854]
["Medium","O15040","Tectonin beta-propeller repeat-containing protein 2 [OS=Homo sapiens]",1,1,1,1,1411,153.8,5.55,2.2,"other metabolic processes;transport","other cell component","","TECPR2","ENSG00000196663","","","",26.4,15.9,22.3,23.7,18.5,17.7,1.0784641068447411,0.10897816190513912,0.6848903886224125,0.16437892839886067,0.8178045808783906,0.08735046110298948,6539]
["High","O15042","U2 snRNP-associated SURP motif-containing protein [OS=Homo sapiens]",34,28,87,28,1029,118.2,8.47,154.17,"RNA metabolism OR transcription;other metabolic processes","nucleus","","U2SURP","ENSG00000163714","","mRNA Splicing - Major Pathway","Spliceosome",4008,3901.3,3820.4,4470.7,4276.8,4403.2,0.8919449154797844,-0.1649734796050603,3.8239756467991033E-3,2.4174848822156143,0.06576564284186652,1.1820009304140828,454]
["High","O15047","Histone-lysine N-methyltransferase SETD1A [OS=Homo sapiens]",11,13,20,12,1707,185.9,5.14,42.36,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETD1A","ENSG00000099381","Histone modifications","PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Lysine degradation; Metabolic pathways",633.9,661,596.6,645.2,598,633.4,1.0079398912927635,0.011409605981150931,0.8425800320648619,0.07438883724192823,0.9127171046562765,0.0396638105542994,7208]
["Low","O15050","TPR and ankyrin repeat-containing protein 1 [OS=Homo sapiens]",0,1,1,1,2925,336,6.76,0,"","","","TRANK1","ENSG00000168016","","","",44.2,52,53.3,55.3,47.1,43.3,1.0260809883321895,0.037144607020954935,0.7940774197574183,0.10013715332312677,0.885357203122365,0.052881475012482866,7003]
["High","O15054","Lysine-specific demethylase 6B [OS=Homo sapiens]",2,2,2,2,1643,176.5,8.54,2.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6B","ENSG00000132510","Pathways affected in adenoid cystic carcinoma; Vitamin D-sensitive calcium signaling in depression","Oxidative Stress Induced Senescence; HDMs demethylate histones","",50,68.7,65.6,58.3,61.6,53,1.065934065934066,0.09211820198843139,0.5792239802326851,0.23715346637730475,0.7506358236774779,0.12457071296557538,6025]
["High","O15056","Synaptojanin-2 [OS=Homo sapiens]",3,5,5,5,1496,165.4,7.34,10.21,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ2","ENSG00000078269","","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",203.7,215.4,239.3,213.9,228,238.3,0.967950602763893,-0.046994670286216206,0.5961430237439087,0.2246495339324663,0.7615649099136844,0.11829307484146442,6112]
["High","O15061-1","Synemin [OS=Homo sapiens]",3,3,3,3,1565,172.7,5.16,2.25,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SYNM","ENSG00000182253","","","",25.2,27.2,30.3,24.1,26.1,20.7,1.166431593794076,0.22210170193175827,0.14335835362894334,0.8435769952235987,0.3736121579221594,0.42757899959239215,2996]
["High","O15063","Uncharacterized protein KIAA0355 [OS=Homo sapiens]",4,3,3,3,1070,115.9,7.15,9.75,"signal transduction","cytosol;other cell component","other molecular function","GARRE1","ENSG00000166398","","RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",117.2,105.5,113.3,110.1,116.5,106,1.010222489476849,0.014673064378853505,0.8175362272707278,0.08749299346257117,0.8985533308741332,0.04645614157448039,7104]
["High","O15066","Kinesin-like protein KIF3B [OS=Homo sapiens]",12,9,10,6,747,85.1,7.69,24.97,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3B","ENSG00000101350","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",575.8,599.5,540.8,577.9,605.5,615.9,0.9537597954760182,-0.06830212583707032,0.24704121555442837,0.6072305844139745,0.49598812318050317,0.3045287229027988,3889]
["High","O15067","Phosphoribosylformylglycinamidine synthase [OS=Homo sapiens]",35,36,100,36,1338,144.6,5.76,222.91,"other metabolic processes;other biological processes","cytosol","other molecular function","PFAS","ENSG00000178921","","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Metabolic pathways",4687,4779.3,4571.3,4922.7,4720.6,4724.6,0.977011254254275,-0.03355291410279417,0.28759294001954366,0.5412217794441914,0.5322412125320212,0.2738915001674369,4219]
["High","O15068","Guanine nucleotide exchange factor DBS [OS=Homo sapiens]",4,3,3,3,1137,128,6.43,6.81,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","MCF2L","ENSG00000126217","","CDC42 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RHOB GTPase cycle","",66.3,64.8,75.4,81,80.3,75.6,{"$f":"AVERAGE(T258:V258)/AVERAGE(W258:Y258)","v":0.8716758125791473},{"$f":"LOG(Z258,2)","v":-0.1981364169334236},{"$f":"TTEST(T258:V258,W258:Y258,2,2)","v":0.052788232387557525},{"$f":"-LOG10(AB258)","v":1.2774628800938015},{"$f":"AB258*7808/AF258","v":0.23052042420696262},{"$f":"-LOG10(AD258)","v":0.6372905898950649},1788]
["High","O15069","NAC-alpha domain-containing protein 1 [OS=Homo sapiens]",1,1,2,1,1562,161,4.23,4.2,"transport","translational apparatus;nucleus;other cell component","other molecular function","NACAD","ENSG00000136274","","","",29.9,22.2,26.3,34.2,30.8,30.1,0.8243953732912722,-0.27859168674535545,0.09528714321910499,1.0209656933351379,0.30897093615231386,0.5100823712622895,2408]
["High","O15075-1","serine/threonine-protein kinase DCLK1 [OS=Homo sapiens]",11,4,8,4,740,82.2,8.66,21.01,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","DCLK1; LOC111158544","ENSCANG00000018654; ENSCCAG00000004898; ENSCJAG00000018203; ENSG00000133083; ENSMFAG00000030114; ENSMLEG00000042752; ENSMMUG00000016791; ENSMNEG00000028724; ENSNLEG00000001363; ENSPPAG00000038110; ENSPTRG00000005778; ENSRBIG00000027120; ENSRROG00000019788; ENSSBOG00000035278","Orexin receptor pathway","","",225.3,210.7,247,267.3,275.7,291.5,0.8184541641701617,-0.2890264710725084,0.01649182379420252,1.7827313140364769,0.13771995741725485,0.8610031202503593,935]
["High","O15078-1","Centrosomal protein of 290 kDa [OS=Homo sapiens]",3,6,7,6,2479,290.2,5.95,16.08,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CEP290","ENSG00000198707","Clear cell renal cell carcinoma pathways; Ciliary landscape; Joubert syndrome; Ciliopathies","Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",537.8,591.9,613.2,696.3,621.4,604,0.9069573814851433,-0.14089333571529938,0.17437674544453569,0.7585114322388923,0.41271101195239,0.3843539431256007,3299]
["High","O15083","ERC protein 2 [OS=Homo sapiens]",6,7,14,1,957,110.5,6.99,27.61,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","ERC2","ENSG00000187672","Exercise-induced circadian regulation","","",105.8,57.8,66.4,66.6,48.7,79.4,1.1813045711350798,0.24038097711144313,0.5326460410986658,0.27356129653229927,0.7174228547349288,0.14422479224443552,5797]
["High","O15084","serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A [OS=Homo sapiens]",12,9,11,9,1053,112.9,6.25,28.1,"","cytosol;nucleus","","ANKRD28","ENSG00000206560","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",341.9,338.2,326,318.3,346.7,327.2,1.014009272324128,0.02007084472278715,0.6566859177115848,0.18264229683213565,0.7996574618671326,0.09709600585560746,6412]
["High","O15085-2","Isoform 2 of Rho guanine nucleotide exchange factor 11 [OS=Homo sapiens]",15,16,21,16,1562,172.1,5.54,39.81,"","","","ARHGEF11","","","","",506.3,634.9,518.7,554.2,551.1,549.1,1.0033244680851066,0.004788238849046152,0.9664639637297732,0.014814334749840417,0.9814215930292716,0.008144390995111458,7689]
["High","O15091","Mitochondrial ribonuclease P protein 3 [OS=Homo sapiens]",16,8,10,8,583,67.3,8.78,22.84,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","other molecular function","PRORP","ENSG00000100890","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",339.5,330.7,368.5,445.8,391.2,415,0.829632587859425,-0.2694555307509117,0.021840493699132373,1.6607375487335303,0.15446610036487823,0.811166817468075,1104]
["High","O15111","Inhibitor of nuclear factor kappa-B kinase subunit alpha [OS=Homo sapiens]",4,2,2,2,745,84.6,6.73,8.32,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CHUK","ENSG00000213341","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Constitutive Signaling by AKT1 E17K in Cancer; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; AKT phosphorylates targets in the cytosol","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",60.4,67.8,64.2,64.6,58,53.9,1.0900849858356938,0.12444061561149897,0.23338677064519062,0.6319237652513497,0.4794222323592866,0.31928183019581813,3801]
["High","O15116","U6 snRNA-associated Sm-like protein LSm1 [OS=Homo sapiens]",29,4,6,4,133,15.2,5.22,5.98,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM1","ENSG00000175324","","mRNA decay by 5' to 3' exoribonuclease","RNA degradation",284,293.3,320,369.8,338.9,323.4,0.8693925007266737,-0.20192044372857615,0.06107780741137286,1.2141165617635101,0.24658506735677313,0.6080332268518576,1934]
["High","O15118","Niemann-Pick C1 protein [OS=Homo sapiens]",5,7,10,7,1278,142.1,5.36,21.92,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","NPC1","ENSG00000141458","Irinotecan pathway; Irinotecan pathway; Irinotecan pathway; Ebola virus infection in host; Irinotecan pathway; Irinotecan pathway","LDL clearance","Lysosome; Cholesterol metabolism",512.9,522.8,541.7,456,446.7,449.4,1.166629687153317,0.2223466919026869,1.0748343138841127E-3,2.968658477247575,0.03849681799452822,1.4145751661935442,218]
["High","O15120","1-acyl-sn-glycerol-3-phosphate acyltransferase beta [OS=Homo sapiens]",6,1,2,1,278,30.9,9.01,4.84,"other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","AGPAT2","ENSG00000169692","Adipogenesis; Triacylglyceride synthesis; Ciliary landscape; Congenital generalized lipodystrophy (CGL)","Neutrophil degranulation; Synthesis of PA","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fat digestion and absorption",18.9,15.7,19.3,18.7,16.6,18.2,1.0074766355140186,0.010746381463995985,0.923445225170345,0.034588859954942576,0.9586837279789993,0.01832464397418615,7521]
["High","O15121","Sphingolipid delta(4)-desaturase DES1 [OS=Homo sapiens]",6,3,5,3,323,37.8,7.46,14.01,"cell organization and biogenesis;other metabolic processes;developmental processes","plasma membrane;other membranes;mitochondrion;ER/Golgi","other molecular function","DEGS1","ENSG00000143753","Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence","Neutrophil degranulation; Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",108.1,159.7,120,118.4,103.4,121.9,1.1283095723014254,0.1741629517344949,0.42587647110590104,0.37071635323722346,0.6476905894808872,0.18863241291401264,5134]
["High","O15126-1","Secretory carrier-associated membrane protein 1 [OS=Homo sapiens]",6,2,5,2,338,37.9,7.42,13.7,"transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP1","ENSG00000085365","","Neutrophil degranulation","",276.8,259.3,290.3,318.7,286.6,308.3,0.9045534150612962,-0.14472239649778298,0.08964171862882887,1.047489825677117,0.2993680663190316,0.5237945278443028,2338]
["High","O15127","Secretory carrier-associated membrane protein 2 [OS=Homo sapiens]",17,4,13,4,329,36.6,6.1,33.7,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP2","ENSG00000140497","Serotonin transporter activity; Monoamine transport","","",650,764.1,673.3,602.3,551.6,594.7,1.1937550040032023,0.25550678067548477,0.04176483913115664,1.3791891870603628,0.20432322301758835,0.6896822694164381,1596]
["High","O15143","Actin-related protein 2/3 complex subunit 1B [OS=Homo sapiens]",30,9,23,9,372,40.9,8.35,62.02,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ARPC1B","ENSG00000130429","Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",1467.8,1797.5,1520,1462.1,1745.6,1690.8,0.9768908849647853,-0.03373066730113123,0.792504388728652,0.10099832406874892,0.884108339361811,0.05349451292352858,6999]
["High","O15144","Actin-related protein 2/3 complex subunit 2 [OS=Homo sapiens]",59,17,56,17,300,34.3,7.36,116.07,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","ARPC2","ENSG00000163466","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",2459.8,2893.8,2737.4,2739,3446.9,3096,0.8716965276505888,-0.19810213219670714,0.17424123032557942,0.7588490710035686,0.41276563300428526,0.3842964693700114,3296]
["High","O15145","Actin-related protein 2/3 complex subunit 3 [OS=Homo sapiens]",21,4,14,4,178,20.5,8.59,26.18,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC3","ENSG00000111229","Pathogenic Escherichia coli infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",363.5,374.2,474.4,472.6,494.8,488.7,0.8324290914085569,-0.26460071018716513,0.08635460005488092,1.0637145228881832,0.2926461446304298,0.5336571929807221,2304]
["High","O15151","Protein Mdm4 [OS=Homo sapiens]",5,2,2,2,490,54.8,5,2.63,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","nucleus","other molecular function","MDM4","ENSG00000198625","Glioblastoma signaling pathways; Malignant pleural mesothelioma","Regulation of TP53 Activity through Methylation; Ub-specific processing proteases; Regulation of TP53 Degradation; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Oncogene Induced Senescence; Stabilization of p53","p53 signaling pathway; MicroRNAs in cancer",47.2,47.1,51.3,55.8,52,55.4,0.8921568627450982,-0.16463070177279907,0.03300037639098155,1.4814811066798668,0.18550535555132033,0.7316435477588469,1389]
["High","O15155","BET1 homolog [OS=Homo sapiens]",25,2,3,2,118,13.3,9.06,9.82,"cell organization and biogenesis;transport","other membranes;ER/Golgi","other molecular function","BET1","ENSG00000105829","","COPI-mediated anterograde transport; COPII-mediated vesicle transport","SNARE interactions in vesicular transport",143,140.4,141.1,161,174.2,184,0.8176040061633281,-0.2905258295587379,0.009272084310988466,2.032822627990256,0.10553416078746056,0.9766069390383726,686]
["Medium","O15156","Zinc finger and BTB domain-containing protein 7B [OS=Homo sapiens]",1,1,1,1,539,58,5.86,2.12,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB7B","ENSG00000160685","Ectoderm differentiation; Ectoderm differentiation","","",61.2,61.7,57.3,91.2,72.1,89.8,0.7119715527459501,-0.4901084962971457,0.018210725926691047,1.7396727417573894,0.14406215606444145,0.8414500897683906,987]
["High","O15160","DNA-directed RNA polymerases I and III subunit RPAC1 [OS=Homo sapiens]",34,9,31,9,346,39.2,5.5,53.07,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR1C","ENSG00000171453","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase; Cytosolic DNA-sensing pathway",835.9,757.9,862.2,833.5,853.4,833.6,0.9744098393175957,-0.037399393639184715,0.5385810161937756,0.2687489585880592,0.7214343068178075,0.14180320924886877,5829]
["High","O15162","phospholipid scramblase 1 [OS=Homo sapiens]",9,2,2,2,318,35,4.94,2.44,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;transporter activity;nucleic acid binding activity;other molecular function","PLSCR1","ENSG00000188313","EGF/EGFR signaling pathway; Complement system in neuronal development and plasticity","","",65.9,40.9,64,71.9,64,65.9,0.8463825569871161,-0.24061819948586666,0.285085309605716,0.545025161229827,0.5307453737247092,0.2751137827005167,4194]
["High","O15164","Transcription intermediary factor 1-alpha [OS=Homo sapiens]",29,19,35,18,1050,116.8,7.11,75.15,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function","TRIM24","ENSG00000122779","","Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",814.9,875.4,786.3,956.8,880.8,847.9,0.9222118786073357,-0.11682984629483385,0.16938542981070603,0.7711239495245152,0.4068168058941841,0.39060111436200656,3251]
["Medium","O15169","Axin-1 [OS=Homo sapiens]",1,1,1,1,862,95.6,6.96,1.89,"cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","AXIN1","ENSG00000103126","Alzheimer's disease and miRNA effects; Neural crest differentiation; Mesodermal commitment pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Wnt signaling pathway; TGF-beta signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)","Ub-specific processing proteases; Degradation of AXIN; Estrogen-dependent gene expression; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling","Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Colorectal cancer; Endometrial cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",45,61.8,46.9,54.6,42.4,49.6,1.0484311050477488,0.06823206155695924,0.7296347475744052,0.13689449167459034,0.8453758879746187,0.07295014338765726,6739]
["High","O15173","Membrane-associated progesterone receptor component 2 [OS=Homo sapiens]",52,12,38,10,223,23.8,4.88,90.01,"transport;developmental processes;signal transduction","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","PGRMC2","ENSG00000164040","Ciliary landscape","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","",638.5,622,674,687.5,654,686.9,0.9537073555511734,-0.06838145073605643,0.1733533773735361,0.7610676927419273,0.41253982643479725,0.38453411846933966,3281]
["High","O15182","Centrin-3 [OS=Homo sapiens]",34,5,6,5,167,19.5,4.74,10.29,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","CETN3","ENSG00000153140","Breast cancer pathway","","",258.3,228.7,292.4,402.5,312.1,315.7,0.7564786955255751,-0.4026286420453495,0.07417080964099985,1.129766980248022,0.2730436971602673,0.5637678441059485,2121]
["High","O15194-1","CTD small phosphatase-like protein [OS=Homo sapiens]",11,3,4,2,276,31.1,5.54,2.79,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","CTDSPL","ENSG00000144677; ENSPTRG00000014749","","","",117.8,109.5,126.5,137.4,143.6,135.2,0.8500720807304182,-0.23434291704487611,0.019575361921479812,1.7082901996889956,0.14853685702907132,0.8281657697927932,1029]
["High","O15213","WD repeat-containing protein 46 [OS=Homo sapiens]",26,15,25,15,610,68,9.67,52.8,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","WDR46","ENSG00000204221; ENSG00000206284; ENSG00000226916; ENSG00000227057; ENSG00000236222","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",620.7,633.5,625.6,645.1,621.8,692.8,0.9592284533346941,-0.060053641226933456,0.27787299286894396,0.556153661275734,0.525207535299132,0.2796690515936847,4131]
["High","O15226","NF-kappa-B-repressing factor [OS=Homo sapiens]",36,22,44,22,690,77.6,8.79,73.45,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","NKRF","ENSG00000186416","Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway","","",2489.6,2659.5,2358.2,2342.8,2220.8,2300.2,1.0937527317229523,0.129286620179924,0.08518905032159407,1.0696162231970467,0.290207724655762,0.5372910318337637,2292]
["High","O15228","Dihydroxyacetone phosphate acyltransferase [OS=Homo sapiens]",26,16,30,16,680,77.1,6.57,55.14,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","other molecular function","GNPAT","ENSG00000116906","Triacylglyceride synthesis","Peroxisomal protein import; Plasmalogen biosynthesis; Synthesis of PA","Glycerophospholipid metabolism; Peroxisome",1085.4,917.8,1136.2,1077.8,1096.5,1070,0.9676663687081959,-0.04741837298318268,0.6265702925726166,0.20303020006656008,0.7802648874652298,0.10775793623864109,6270]
["High","O15230","Laminin subunit alpha-5 [OS=Homo sapiens]",11,31,40,31,3695,399.5,7.02,79.53,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;extracellular structural activity","LAMA5","ENSG00000130702","Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Malignant pleural mesothelioma","Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer",1713.4,1814.7,1660.6,1653.2,1575.2,1604.1,1.073709260217279,0.10260339218093407,0.0789029032331784,1.102907016626421,0.28156940970962385,0.5504145296291787,2188]
["High","O15231-1","zinc finger protein 185 [OS=Homo sapiens]",4,3,4,2,689,73.5,7.01,8.4,"","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ZNF185","ENSG00000147394","","","",231.8,190.9,204.5,192.8,174.3,170.4,1.1668837209302327,0.22266080475102346,0.09733660489137946,1.0117238060548506,0.3113495333846337,0.5067517808134038,2441]
["High","O15231-2","Isoform 2 of Zinc finger protein 185 [OS=Homo sapiens]",4,2,3,1,452,48.6,5.43,4.51,"","","","ZNF185","","","","",115,131.2,98.3,103.1,96.4,78.2,1.2405473532589124,0.3109768057728076,0.1386859491796602,0.857967536784307,0.3683196908825806,0.43377506253782894,2940]
["High","O15234","Protein CASC3 [OS=Homo sapiens]",10,6,6,6,703,76.2,6.48,15.76,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CASC3","ENSG00000108349","","Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Nucleocytoplasmic transport; mRNA surveillance pathway",410.4,435,404.2,497.8,446.1,499.7,0.8656137434192296,-0.20820468975525355,0.031479619791515825,1.5019705216574397,0.18179946104449377,0.7404074086044216,1352]
["High","O15235","28S ribosomal protein S12, mitochondrial [OS=Homo sapiens]",24,2,3,2,138,15.2,10.29,10.61,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS12","ENSG00000128626; ENSG00000283018","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",60,62.2,47,56.7,64.5,60.5,0.9312052834342323,-0.10282885111416605,0.4718364522469345,0.32620851025381503,0.6757334958077889,0.17022455275781556,5452]
["High","O15240","Neurosecretory protein VGF [OS=Homo sapiens]",29,17,38,17,615,67.2,4.78,79.58,"cell-cell signaling;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;ER/Golgi;other cell component","signal transduction activity or receptor binding","VGF","ENSG00000128564","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; NGF-stimulated transcription","",1294,2122.7,1688.6,375.9,351.2,302,4.960936740841512,2.310612560887896,4.820454187304259E-3,2.316912040236852,0.07438360927761196,1.128522752418016,506]
["High","O15243","Leptin receptor gene-related protein [OS=Homo sapiens]",18,3,4,3,131,14.2,6.51,5.11,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding","LEPROT","ENSG00000213625","","","",260.1,231,292.4,345.3,314.5,301,0.8154662781015821,-0.2943028763456913,0.055228740795324485,1.2578348584941634,0.2357714642590998,0.6275087593119448,1829]
["High","O15254","Peroxisomal acyl-coenzyme A oxidase 3 [OS=Homo sapiens]",13,5,7,5,700,77.6,7.25,11.54,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOX3","ENSG00000087008","PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","Fatty acid degradation; beta-Alanine metabolism; alpha-Linolenic acid metabolism; Propanoate metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; PPAR signaling pathway; cAMP signaling pathway; Peroxisome; Alcoholic liver disease",40.3,48.5,60.5,49.8,44.2,51.7,1.0247083047357586,0.03521328807002894,0.8578277307977822,0.0665999185331866,0.9210559573802369,0.035713984088462256,7272]
["High","O15258","Protein RER1 [OS=Homo sapiens]",14,2,5,2,196,22.9,9.54,7.25,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","RER1","ENSG00000157916","","","",203.7,289.9,206.8,200.9,184.4,208.1,1.1803168183350186,0.23917415695329086,0.2874037480088199,0.5415075725659722,0.5326485792672362,0.2735592270341845,4213]
["High","O15260-1","surfeit locus protein 4 [OS=Homo sapiens]",17,4,16,4,269,30.4,7.78,29.12,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","SURF4","ENSG00000148248; ENSG00000280951; ENSGGOG00000014456; ENSNLEG00000013096; ENSPTRG00000021519","","COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation","",442.2,360.6,444.7,398.8,443.6,425.3,0.9840656306697168,-0.02317355789578688,0.8362647892468933,0.07765618870809907,0.9091555937677169,0.041361784839517954,7182]
["Medium","O15265","Ataxin-7 [OS=Homo sapiens]",2,1,1,1,892,95.4,9.85,2.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","","ATXN7","ENSG00000163635","","Ub-specific processing proteases; HATs acetylate histones","",20.3,16.4,15.2,18.6,16.3,22.1,0.9105263157894735,-0.1352273806942235,0.49791023814259716,0.3028489435716565,0.6943531236680477,0.15841960640800481,5599]
["High","O15269","serine palmitoyltransferase 1 [OS=Homo sapiens]",31,14,50,14,473,52.7,6.01,111.29,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC1","ENSG00000090054","Sphingolipid pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",1841.3,1806.4,1792.6,1506.4,1535.7,1534.4,1.1887468589533485,0.24944152903249348,7.7388720574402431E-5,4.11132233323525,0.01184806137735165,1.9263527046745512,51]
["High","O15270","Serine palmitoyltransferase 2 [OS=Homo sapiens]",18,8,17,8,562,62.9,7.78,38.64,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC2","ENSG00000100596","Sphingolipid pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",551.2,448.1,580.9,434.3,453.8,448.8,1.181988181614182,0.2412156104631175,0.11685779062893108,0.9323423289339681,0.3399499363750722,0.4685850357722871,2684]
["High","O15287","Fanconi anemia group G protein [OS=Homo sapiens]",12,5,6,5,622,68.5,5.47,11.98,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus","nucleic acid binding activity","FANCG","ENSG00000221829","Retinoblastoma gene in cancer; DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",50.2,58.2,55.3,53.1,70.4,47.8,0.9556333917104494,-0.06547082960984572,0.7431526996848324,0.1289219401871738,0.8535652072873157,0.06876329577557924,6798]
["High","O15294","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit [OS=Homo sapiens]",11,12,27,12,1046,116.9,6.7,58.4,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","OGT","ENSG00000147162","Ectoderm differentiation; Ectoderm differentiation; Malignant pleural mesothelioma","UCH proteinases; Regulation of necroptotic cell death; HATs acetylate histones","Other types of O-glycan biosynthesis; Insulin resistance",1012.9,1013.6,986.8,1320.7,1282.9,1316.9,0.7686009437571738,-0.37969334701519397,3.4852003669037545E-5,4.457772248917697,0.009718730165994468,2.0123904756012814,28]
["High","O15305","Phosphomannomutase 2 [OS=Homo sapiens]",38,10,42,10,246,28.1,6.77,55.91,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PMM2","ENSG00000140650","Nephrotic syndrome","Defective PMM2 causes PMM2-CDG (CDG-1a); Synthesis of GDP-mannose","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",2088.2,2204.7,2069.5,2329.4,2112,2210.9,0.9564210874434407,-0.06428215553764399,0.271116740195548,0.5668436659307717,0.5177010289671896,0.2859209718264724,4089]
["High","O15318","DNA-directed RNA polymerase III subunit RPC7 [OS=Homo sapiens]",14,3,3,3,223,25.9,4.63,5.5,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","POLR3G","ENSG00000113356","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",67.5,49,78.1,114,91.9,87.7,0.6628065395095367,-0.5933402580621014,0.04878104242528778,1.3117489232778632,0.22260805333527,0.652459128160328,1711]
["High","O15320","Endoplasmic reticulum export factor CTAGE5 [OS=Homo sapiens]",25,18,32,18,804,90.9,5.22,81.02,"","","","","","","","",1676.4,1399.2,1722.1,1908,1805.5,1803.5,0.8696211709262281,-0.2015410316857897,0.08776338648375914,1.0566866271968585,0.2951147810788938,0.5300090379407781,2322]
["High","O15321-1","Transmembrane 9 superfamily member 1 [OS=Homo sapiens]",5,3,3,3,606,68.8,7.17,4.2,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","TM9SF1","ENSCANG00000029500; ENSCCAG00000032112; ENSG00000100926; ENSG00000285465; ENSPPAG00000042444; ENSPTRG00000032568; ENSRBIG00000029944; ENSRROG00000042511","","","",121.4,124.5,132.8,130.8,131.9,136.4,0.9488849912302683,-0.07569485762685195,0.14884764096514203,0.8272580439459766,0.37992885931867565,0.4202977162720199,3059]
["High","O15344-1","E3 ubiquitin-protein ligase Midline-1 [OS=Homo sapiens]",26,16,36,16,667,75.2,6.8,95.44,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","MID1","ENSCANG00000031338; ENSCCAG00000029160; ENSCJAG00000000987; ENSCSAG00000015273; ENSG00000101871; ENSMFAG00000037182; ENSMLEG00000034816; ENSMMUG00000020179; ENSMNEG00000026727; ENSPANG00000006683; ENSPPAG00000038224; ENSRBIG00000037000; ENSTSYG00000003295","","Interferon gamma signaling","Ubiquitin mediated proteolysis",1385.6,1588.5,1415,1609.7,1718.6,1674.8,0.8772760888249287,-0.18889714811778227,0.04447333062040985,1.351900344895552,0.21032572106854033,0.6771076134997102,1651]
["High","O15347","High mobility group protein B3 [OS=Homo sapiens]",13,2,5,2,200,23,8.37,4.96,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","HMGB3","ENSG00000029993","","","",129.9,96.6,131.4,213.3,158.7,108.8,0.7443843594009982,-0.4258803522948014,0.27276212895047813,0.5642159284787733,0.5193188741393157,0.2845658931076226,4101]
["High","O15355","Protein phosphatase 1G [OS=Homo sapiens]",56,25,161,25,546,59.2,4.36,383.7,"protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","PPM1G","ENSG00000115241","VEGFA-VEGFR2 signaling pathway; mRNA processing","","",6169.7,7199.1,5710.4,5994.7,5335.9,5694.1,1.1206776037169526,0.1643713036428235,0.22646262677601708,0.6450034595415521,0.471022959474465,0.3269579231682442,3754]
["High","O15357","Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [OS=Homo sapiens]",18,18,39,18,1258,138.5,6.54,88.27,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","INPPL1","ENSG00000165458","EGF/EGFR signaling pathway; Insulin signaling","Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; B cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway",1471.3,1392.6,1422.2,1608.1,1491.6,1618.7,0.90837995930824,-0.13863221725025746,0.03681846719285777,1.433934295776065,0.19306822823494524,0.7142891888696058,1489]
["High","O15360","Fanconi anemia group A protein [OS=Homo sapiens]",6,5,6,5,1455,162.7,6.6,5.61,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","","FANCA","ENSG00000187741","DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",29.3,22.4,30.3,27.2,24.6,31,0.9903381642512078,-0.014006857993879096,0.9356202293597047,0.028900396734288607,0.9659292279307913,0.015054692471761541,7563]
["High","O15371","Eukaryotic translation initiation factor 3 subunit D [OS=Homo sapiens]",51,21,82,21,548,63.9,6.05,173.31,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3D","ENSG00000100353","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",2581.4,2461.2,2665.1,2622.5,2659.1,2722.2,0.9630050725905196,-0.054384697460462754,0.20884242414913576,0.68018127433662,0.45057796290589996,0.34623005278618396,3619]
["High","O15372","Eukaryotic translation initiation factor 3 subunit H [OS=Homo sapiens]",55,16,78,16,352,39.9,6.54,148.32,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3H","ENSG00000147677","Translation factors; VEGFA-VEGFR2 signaling pathway; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Measles",4316.5,3392.6,4210.2,4251.1,4263.7,4201.6,0.937317165235444,-0.09339079162630572,0.41503346477292863,0.38191688405833224,0.6390418641189167,0.19447068994757005,5071]
["High","O15379","Histone deacetylase 3 [OS=Homo sapiens]",9,4,8,4,428,48.8,5.16,16.06,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","HDAC3","ENSG00000171720","Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome","Cytoprotection by HMOX1; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling","Neutrophil extracellular trap formation; Thyroid hormone signaling pathway; Alcoholism; Viral carcinogenesis",361.3,345.9,368.5,360.3,390.1,389.1,0.9440105309346205,-0.08312514118752326,0.14658094527338317,0.8339224819491654,0.37784880181399,0.4226819506233858,3029]
["High","O15381-1","Nuclear valosin-containing protein-like [OS=Homo sapiens]",39,28,85,28,856,95,6.48,180.61,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","NVL","ENSG00000143748","","","Ribosome biogenesis in eukaryotes",2755.3,2309.2,2672.4,3063.6,2987.6,3018.3,0.8530679750813166,-0.22926739038311333,0.032860600960176845,1.4833244983780696,0.18511946053178993,0.7325479239952221,1386]
["High","O15397-1","Importin-8 [OS=Homo sapiens]",19,15,32,14,1037,119.9,5.16,74.12,"transport;signal transduction","cytosol;nucleus","other molecular function","IPO8","ENSG00000133704","","Transcriptional regulation by small RNAs","Nucleocytoplasmic transport",794.1,709.6,840.9,853.8,936.5,945.8,0.8569131245203027,-0.22277914629854956,0.05393235554253685,1.2681506111083678,0.23252558369747528,0.6335292567637908,1811]
["High","O15400","Syntaxin-7 [OS=Homo sapiens]",39,7,19,7,261,29.8,5.55,35.83,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STX7","ENSG00000079950","","","SNARE interactions in vesicular transport; Phagosome",344.1,392.8,360.4,327.9,356.8,332.5,1.078745576091231,0.10935464295989263,0.18904456209365708,0.723435810693322,0.4288378677592314,0.36770687202622804,3442]
["Low","O15417-1","Trinucleotide repeat-containing gene 18 protein [OS=Homo sapiens]",0,1,2,1,2968,314.3,8.7,2.13,"","other membranes;cytosol;mitochondrion;nucleus","other molecular function","TNRC18","ENSG00000182095","","","",108.6,62.4,100.7,124.7,151.4,140.9,0.6515587529976019,-0.6180328181100511,0.04067015724171402,1.3907241484934525,0.20136498905726258,0.69601603716372,1577]
["Medium","O15427","Monocarboxylate transporter 4 [OS=Homo sapiens]",2,1,1,1,465,49.4,7.96,2.4,"transport","plasma membrane;other membranes;nucleus;other cell component","transporter activity","SLC16A3","ENSG00000141526","Metabolic reprogramming in colon cancer","Pyruvate metabolism; Basigin interactions; Proton-coupled monocarboxylate transport","Central carbon metabolism in cancer",133.3,157.8,128.3,67.5,49.2,51.2,2.4979154258487197,1.3207246311595626,1.4852947762784468E-3,2.8281873463422653,0.04343513712802289,1.3621588030482055,267]
["Medium","O15431","High affinity copper uptake protein 1 [OS=Homo sapiens]",6,1,2,1,190,21.1,7.42,5.3,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","SLC31A1","ENSG00000136868","Copper homeostasis","Metal ion SLC transporters","Platinum drug resistance; Mineral absorption",86.7,59.4,86.5,78.9,85.4,87.7,0.923015873015873,-0.11557263691406054,0.5310424800105281,0.27487073674103685,0.7168706230847516,0.1445592163688759,5784]
["High","O15439-1","multidrug resistance-associated protein 4 [OS=Homo sapiens]",10,9,10,9,1325,149.4,8.19,16.16,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","ABCC4","ENSG00000125257","Fluoropyrimidine activity; Drug induction of bile acid pathway; Ectoderm differentiation; Pregnane X receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; TYROBP causal network in microglia; Aspirin and miRNAs; Proximal tubule transport; FOXA2 pathway; Prostaglandin synthesis and regulation","ABC-family proteins mediated transport; Platelet degranulation","Antifolate resistance; ABC transporters; cAMP signaling pathway; Bile secretion",234.4,174,232.3,245.1,251.4,260.2,{"$f":"AVERAGE(T322:V322)/AVERAGE(W322:Y322)","v":0.8467027884234175},{"$f":"LOG(Z322,2)","v":-0.24007245462799479},{"$f":"TTEST(T322:V322,W322:Y322,2,2)","v":0.12912238981453972},{"$f":"-LOG10(AB322)","v":0.8889984445669965},{"$f":"AB322*7808/AF322","v":0.35512068322364426},{"$f":"-LOG10(AD322)","v":0.44962403243421833},2839]
["High","O15440","Multidrug resistance-associated protein 5 [OS=Homo sapiens]",9,8,12,8,1437,160.6,8.66,25.56,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","ABCC5","ENSG00000114770","Fluoropyrimidine activity; Nuclear receptors meta-pathway; NRF2 pathway","ABC-family proteins mediated transport; Hyaluronan biosynthesis and export","Antifolate resistance; ABC transporters",198.5,191.9,214.4,175.9,168,162.2,1.1950207468879668,0.2570356652123507,0.013317520992479076,1.8755766099618947,0.1242332185296017,0.9057622632965192,837]
["High","O15446-1","DNA-directed RNA polymerase I subunit RPA34 [OS=Homo sapiens]",10,3,3,3,510,55,8.51,5.83,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytosol;mitochondrion;nucleus;other cell component","other molecular function","POLR1G","ENSG00000117877","","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase",66.8,58.2,58.9,198,68.1,54.9,0.5728971962616822,-0.8036518175977279,0.3742997385743713,0.4267804762137844,0.6062087448223795,0.2173778030381559,4821]
["High","O15460-1","Prolyl 4-hydroxylase subunit alpha-2 [OS=Homo sapiens]",13,6,8,6,535,60.9,5.71,16.6,"protein metabolism;other metabolic processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","P4HA2","ENSG00000072682","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","Arginine and proline metabolism; Metabolic pathways",493.5,465.8,550.1,580.7,593.9,579.3,0.8605963851987002,-0.21659131440460402,0.032004396654660136,1.494790355689614,0.18280199640057523,0.738019065598801,1367]
["High","O15484","calpain-5 [OS=Homo sapiens]",28,13,18,13,640,73.1,7.64,34.33,"protein metabolism;signal transduction","other cell component","other molecular function","CAPN5","ENSG00000149260","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",799.6,824.3,832.7,695.3,734.1,730.9,1.137156876359765,0.18543129480557355,3.4299452990301563E-3,2.4647128060560024,0.06228142533680804,1.2056414569769534,430]
["High","O15488-1","Glycogenin-2 [OS=Homo sapiens]",10,4,10,4,501,55.1,5.1,27.53,"other metabolic processes","cytosol;other cell component","other molecular function","GYG2","ENSG00000056998","Glycogen synthesis and degradation","Glycogen synthesis; Glycogen storage disease type 0 (liver GYS2); Glycogen storage disease type IV (GBE1); Glycogen breakdown (glycogenolysis)","Starch and sucrose metabolism; Metabolic pathways",786.8,742,779.4,776,774.1,814.3,0.9762307562172222,-0.03470589023311975,0.3815845423880398,0.4184092264510335,0.6121660380040713,0.21313076803590444,4867]
["High","O15498","Synaptobrevin homolog YKT6 [OS=Homo sapiens]",34,7,37,7,198,22.4,6.92,81.66,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","YKT6","ENSG00000106636","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport","SNARE interactions in vesicular transport",1758.1,1932.3,1921.2,1650.7,1675.7,1691.6,1.1182941410920684,0.16129970524864645,0.026341321892900307,1.5793624345227861,0.16817092505295633,0.7742490869004363,1223]
["High","O15504","nucleoporin-like protein 2 [OS=Homo sapiens]",17,7,10,7,423,44.8,9.19,20.54,"transport","other membranes;cytosol;nucleus","other molecular function","NUP42","ENSG00000136243","","HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus","Nucleocytoplasmic transport",361.9,379.8,356.7,377.7,322.1,364.1,1.0324278597612557,0.04604097776991675,0.5604970295746492,0.2514266846617951,0.7373817703317374,0.13230760329376964,5935]
["High","O15511-1","Actin-related protein 2/3 complex subunit 5 [OS=Homo sapiens]",40,4,5,4,151,16.3,5.67,16.5,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","Arpc5; ARPC5","ENSDLEG00000020693; ENSG00000162704; ENSGGOG00000007894; ENSPCTG00005002795; ENSPPAG00000038421; ENSPPYG00000000425; ENSPTRG00000001767; ENSRNOG00000028062; ENSSBOG00000027275; ENSSSCG00000015560; ENSSSCG00070012419; ENSSTOG00000001001","Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton","Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Neutrophil degranulation; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",81.1,78.1,87.5,111.9,95,93.3,0.8217854763491006,-0.2831662613205654,0.05289374215798903,1.276595706169266,0.2302086615215041,0.6378783402187039,1794]
["High","O15514","DNA-directed RNA polymerase II subunit RPB4 [OS=Homo sapiens]",11,1,3,1,142,16.3,4.79,2.94,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","POLR2D","ENSG00000144231","Pyrimidine metabolism","Estrogen-dependent gene expression; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; mRNA Splicing - Major Pathway; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere","RNA polymerase; Huntington disease",13.2,9.9,20.3,38.3,23.7,18.6,0.5384615384615385,-0.8930847960834879,0.13579790329555463,0.8671069354620006,0.36512053337868133,0.43756374283142124,2904]
["High","O15523","atp-dependent rna helicase ddx3y [OS=Homo sapiens]",60,37,183,9,660,73.1,7.55,381.16,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX3Y","ENSG00000067048","Novel intracellular components of RIG-I-like receptor (RLR) pathway","","",784.7,793.8,804.5,756,809,772,1.0196833547282842,0.028121217407445692,0.4106283743193091,0.3865510442870482,0.636400624590148,0.19626940279050697,5038]
["Medium","O15525","transcription factor MafG [OS=Homo sapiens]",6,1,2,1,162,17.8,10.04,2.33,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","MAFG","ENSG00000197063","Quercetin and Nf-kB / AP-1 induced apoptosis; Nuclear receptors meta-pathway; NRF2 pathway; Ethanol metabolism production of ROS by CYP2E1","Factors involved in megakaryocyte development and platelet production","",119.7,113.1,117.9,146.3,129.3,129.7,0.8652849740932644,-0.2087527447940279,0.037464682307647025,1.4263779457729622,0.19385304139039625,0.7125273808899165,1509]
["Medium","O15527-1","N-glycosylase/DNA lyase [OS=Homo sapiens]",3,1,1,1,345,38.8,8.6,2.96,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","OGG1","ENSG00000114026","Base excision repair; DNA repair pathways, full network","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Defective OGG1 Substrate Binding; Defective OGG1 Substrate Processing","Base excision repair",130,146.2,133,131.1,147.9,144.9,0.9653220099079973,-0.05091782130976668,0.5323044812657042,0.273839877654457,0.7173340334350393,0.14427856386356464,5794]
["High","O15530-1","3-phosphoinositide-dependent protein kinase 1 [OS=Homo sapiens]",10,5,8,5,556,63.1,7.36,12.47,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function","PDPK1","ENSG00000140992","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; Serotonin HTR1 group and FOS pathway","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of TP53 Degradation; PIP3 activates AKT signaling; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ","Platinum drug resistance; PPAR signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Thyroid hormone signaling pathway; Insulin resistance; Aldosterone-regulated sodium reabsorption; Toxoplasmosis; Proteoglycans in cancer; Chemical carcinogenesis; Endometrial cancer; Prostate cancer; Non-small cell lung cancer; Choline metabolism in cancer; Lipid and atherosclerosis",371.1,365.8,366.7,304.7,285.9,297.7,1.2423730721603066,0.3130984654545634,2.3298497241135252E-4,3.6326720901726874,0.021656507911760006,1.6644115715759336,84]
["High","O15540","Fatty acid-binding protein, brain [OS=Homo sapiens]",22,2,4,2,132,14.9,5.59,9.22,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus","other molecular function","FABP7","ENSG00000164434","PPAR signaling pathway; Fatty acid transporters","Triglyceride catabolism; NOTCH3 Intracellular Domain Regulates Transcription","PPAR signaling pathway",167.8,111.3,211.3,155.7,150.9,137.6,1.104007203962179,0.1427495861438007,0.6286641456819565,0.20158130786439285,0.7812525305562178,0.10720856292169667,6283]
["High","O15541","RING finger protein 113A [OS=Homo sapiens]",22,5,10,5,343,38.8,5.69,21.61,"protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","RNF113A","ENSG00000125352","","","",438.3,446.7,395.7,456,382.5,435.2,1.0054957996388476,7.907054937286051E-3,0.9352279885719385,0.02908250451894747,0.9659074252340867,0.015064495361518609,7560]
["High","O15550","Lysine-specific demethylase 6A [OS=Homo sapiens]",8,9,11,9,1401,154.1,7.44,21.8,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6A","ENSG00000147050","Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Malignant pleural mesothelioma","Activation of anterior HOX genes in hindbrain development during early embryogenesis; HDMs demethylate histones","Transcriptional misregulation in cancer",235.1,262.5,254.8,308.3,259.4,276.1,0.8916804930078218,-0.1654012386961558,0.13869456764463747,0.8579405489350799,0.3682173356577115,0.4338957687835138,2941]
["Medium","O15554","intermediate conductance calcium-activated potassium channel protein 4 [OS=Homo sapiens]",3,1,1,1,427,47.7,9.83,0,"cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","KCNN4","ENSG00000104783","","Ca2+ activated K+ channels","Insulin secretion; GnRH secretion; Salivary secretion; Protein digestion and absorption",198,76.8,206.7,159.3,259.8,202.1,0.7751126851255633,-0.36752203165647973,0.41323606324818246,0.3838017844751463,0.6381620217250412,0.19506904509083955,5056]
["High","O43143","Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [OS=Homo sapiens]",51,42,253,42,795,90.9,7.46,499.59,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","DHX15","ENSG00000109606","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",9449.5,8663.1,9694.9,10102.2,10994.8,10322.3,0.8850451792369657,-0.17617699201097847,0.04284701450926127,1.3680794334216262,0.20676729869487762,0.6845181460392442,1618]
["High","O43148-1","mRNA cap guanine-N7 methyltransferase [OS=Homo sapiens]",32,18,46,17,476,54.8,6.61,90.23,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNMT","ENSG00000101654","mRNA processing","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA surveillance pathway",2668,2528.1,2572.2,2722.4,2573.6,2665.3,0.9757577280092447,-0.03540511102127806,0.3430275117617285,0.46467104693345807,0.5833933373634451,0.23403853504084338,4591]
["High","O43149","Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",2,5,6,3,2961,330.9,5.95,4.67,"","","other molecular function","ZZEF1","ENSG00000074755","","","",209.9,193.4,187.1,222.7,222,204.4,0.9095670928978584,-0.13674803477753295,0.09687783172827259,1.013775589920582,0.3110288281802436,0.507199355862644,2432]
["High","O43149-3","Isoform 3 of Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",2,3,3,1,1085,119.9,5.67,5.48,"","","","ZZEF1","","","","",65.1,75.3,81.3,80.3,81.9,74,0.9386113463166806,-0.09140019452985033,0.41402513019365933,0.38297329759116233,0.6384965863227517,0.19484142031936788,5063]
["High","O43150-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [OS=Homo sapiens]",7,6,8,6,1006,111.6,6.68,19.9,"other biological processes","plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","ASAP2","ENSG00000151693","Vitamin D receptor pathway","","Endocytosis; Fc gamma R-mediated phagocytosis",316.9,292.1,334.3,331.3,374.3,336.5,0.90519144036081,-0.1437051525797265,0.1456773051792258,0.8366081009625649,0.3763892782393763,0.42436275630693604,3022]
["High","O43156","TELO2-interacting protein 1 homolog [OS=Homo sapiens]",10,9,12,9,1089,122,5.97,23.39,"other biological processes","nucleus;other cell component","","TTI1","ENSG00000101407","Fragile X syndrome; Malignant pleural mesothelioma","","mTOR signaling pathway",365.3,309.7,369.9,397.8,488.1,427.9,0.795326533718983,-0.3303807919023956,0.05250733302459308,1.27978004002788,0.23045376967735962,0.6374161834531696,1779]
["High","O43157","Plexin-B1 [OS=Homo sapiens]",8,11,15,11,2135,232.2,5.49,34.98,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PLXNB1","ENSG00000164050","","RHOD GTPase cycle; G alpha (12/13) signalling events; Sema4D induced cell migration and growth-cone collapse; Sema4D mediated inhibition of cell attachment and migration","Axon guidance",361.3,379.9,398.7,337.7,384.5,365.3,1.0481839080459772,0.06789186568122248,0.3710393995005344,0.4305799715785958,0.6041867844213081,0.2188287784266428,4795]
["High","O43159","ribosomal rna-processing protein 8 [OS=Homo sapiens]",22,8,17,8,456,50.7,9.42,31.67,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RRP8","ENSG00000132275","","SIRT1 negatively regulates rRNA expression","",742,648.1,745.7,774.5,689.5,706.5,0.9840129002533979,-0.023250865695196368,0.7926343774637362,0.10092709574263992,0.8841270313195503,0.05348533109826137,7000]
["High","O43164","E3 ubiquitin-protein ligase Praja-2 [OS=Homo sapiens]",19,8,12,7,708,78.2,4.39,16.29,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","PJA2","ENSG00000198961","","Antigen processing: Ubiquitination & Proteasome degradation","",144.9,142.7,130.9,228.4,183.8,181.4,0.7050202156334232,-0.5042634691830972,0.021325100856768534,1.6711089061658575,0.1536036784959859,0.8135983837095903,1084]
["High","O43166-1","Signal-induced proliferation-associated 1-like protein 1 [OS=Homo sapiens]",3,5,5,5,1804,199.9,8.19,7.08,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","SIPA1L1","ENSG00000197555","","Neurexins and neuroligins","Rap1 signaling pathway",453.9,508.4,443.7,450.3,470,465.8,1.0143568285116515,0.02056525013892085,0.7674488553362709,0.11495055733005365,0.8683148329902338,0.06132278007741687,6901]
["High","O43167-1","Zinc finger and BTB domain-containing protein 24 [OS=Homo sapiens]",6,4,5,4,697,78.2,7.61,11.48,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB24","ENSG00000112365","","","",133.7,135,141.6,142.6,148.8,138.4,0.9546300604932527,-0.0669863285352484,0.16975852013625173,0.7701684193726426,0.4070867706461467,0.3903130109311707,3256]
["High","O43169","Cytochrome b5 type B [OS=Homo sapiens]",64,6,33,6,146,16.3,4.97,87.14,"","other membranes","other molecular function","","","","","",810.6,967.4,1038.8,929.5,1100.5,933.6,0.9504656498852747,-0.0732936065044925,0.6071595103717644,0.21669719793014838,0.7688455168638885,0.11416091366200246,6166]
["High","O43172-2","Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",37,16,46,16,521,58.3,7.42,115.97,"","","","PRPF4","","","","",1962.5,2113.1,1907.3,1906.1,1836.5,1918.3,1.0568814146160506,0.07981351092780144,0.1821764703874905,0.7395077165000471,0.42121228332411187,0.37549897247682323,3377]
["High","O43175","D-3-phosphoglycerate dehydrogenase [OS=Homo sapiens]",65,24,440,24,533,56.6,6.71,1021.72,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PHGDH","ENSG00000092621","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",14045.6,14264.3,13478.7,13721.8,13612.2,13820.3,1.0154127272241298,0.02206624809140402,0.4310474918383353,0.36547487761873393,0.6501098737248836,0.1870132379419544,5177]
["High","O43181","NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [OS=Homo sapiens]",17,3,8,3,175,20.1,10.3,11.75,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity","NDUFS4","ENSG00000164258","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",269.2,282,269.4,313.4,312,305.9,0.8811338988510685,-0.18256682428874463,1.5636434216888416E-3,2.805862277905933,0.04488576410495028,1.347891377281496,272]
["High","O43237","Cytoplasmic dynein 1 light intermediate chain 2 [OS=Homo sapiens]",24,9,23,9,492,54.1,6.38,49.13,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYNC1LI2","ENSG00000135720","Intraflagellar transport proteins binding to dynein","COPI-mediated anterograde transport; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection",576.8,463.2,556,507.4,515.4,489.9,1.055067098565479,0.07733475219259694,0.4803975580433795,0.31839920886900824,0.683107654926736,0.16551084791974965,5491]
["High","O43242","26S proteasome non-ATPase regulatory subunit 3 [OS=Homo sapiens]",52,26,184,26,534,60.9,8.44,350.11,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity","PSMD3","ENSG00000108344","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Ub-specific processing proteases; Degradation of beta-catenin by the destruction complex; Degradation of AXIN; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",6221.1,5590.8,6320.1,5895.7,6381,6194.2,0.9816522205198447,-0.026716097433907574,0.6956596269942166,0.15760320044055498,0.825864431742564,0.08309123764117578,6577]
["High","O43251-8","Isoform 8 of RNA binding protein fox-1 homolog 2 [OS=Homo sapiens]",13,4,13,4,451,47.3,6.62,36.56,"","","","RBFOX2","","","","",180.3,259,186.8,273.5,256.7,255,0.7973764645950077,-0.3266670715851798,0.11000402419725108,0.9585914270718416,0.331114657259883,0.48002159416126744,2594]
["High","O43252","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [OS=Homo sapiens]",51,23,86,22,624,70.8,6.86,180.9,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS1","ENSG00000138801","Sulfation biotransformation reaction","Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways",3381.3,3302.9,3398.9,3298.2,3419.5,3388.1,0.9977537651645589,-3.2442769273245235E-3,0.8794400518735125,0.05579375942183852,0.9324644113292212,0.030367734595180246,7364]
["High","O43257","zinc finger HIT domain-containing protein 1 [OS=Homo sapiens]",15,1,1,1,154,17.5,9.41,2.48,"cell organization and biogenesis","nucleus","other molecular function","ZNHIT1","ENSG00000106400","","","",15.8,12.1,14.7,14.8,13.8,12.8,1.0289855072463765,0.041222662726512566,0.7631011166189018,0.11741791095731309,0.8648996252809386,0.06303429105082546,6889]
["High","O43264","Centromere/kinetochore protein zw10 homolog [OS=Homo sapiens]",29,17,52,17,779,88.8,6.27,88.63,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity","ZW10","ENSG00000086827","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",1442.6,1076,1466.4,1522.7,1573.8,1587.2,0.8508230672331702,-0.2330689471884794,0.14265416647117277,0.8457155394712259,0.3723984392533992,0.42899214784390866,2991]
["High","O43272","Proline dehydrogenase 1, mitochondrial [OS=Homo sapiens]",23,8,13,8,600,68,7.87,30.11,"other metabolic processes;stress response;signal transduction;other biological processes","other membranes;mitochondrion;nucleus;other cell component","other molecular function","PRODH","ENSG00000100033","22q11.2 copy number variation syndrome","Proline catabolism","Arginine and proline metabolism; Metabolic pathways",267.8,235.3,319.8,235.7,307.2,256.7,1.0291395697848926,0.04143865082480613,0.8228314886406174,0.08468909680085389,0.9014547864888369,0.04505605093917214,7127]
["High","O43278","Kunitz-type protease inhibitor 1 [OS=Homo sapiens]",4,2,2,2,529,58.4,6.29,5.43,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","enzyme regulator activity","SPINT1","ENSG00000166145","","MET Receptor Activation; Signaling by MST1","Transcriptional misregulation in cancer; Prostate cancer",87.1,103.6,96.2,120.6,108.3,122.3,0.8169134396355353,-0.2917448767666938,0.029974960835761545,1.5232413756627672,0.17852364165188875,0.748304262694216,1311]
["High","O43286","Beta-1,4-galactosyltransferase 5 [OS=Homo sapiens]",8,2,2,2,388,45.1,8.15,3.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","B4GALT5","ENSG00000158470","","N-Glycan antennae elongation; Keratan sulfate biosynthesis; O-linked glycosylation of mucins","Mucin type O-glycan biosynthesis; Metabolic pathways",43.2,36.7,43.6,65.1,81.1,80.9,0.543813298106561,-0.8788166642348478,0.003875671652342581,2.4116530235758966,0.06621716468597565,1.1790294189871116,457]
["High","O43290","U4/U6.U5 tri-snRNP-associated protein 1 [OS=Homo sapiens]",48,33,95,33,800,90.2,6.13,228.79,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","SART1","ENSG00000175467","","mRNA Splicing - Major Pathway","Spliceosome",3892.6,3780.4,3623.2,3804.8,3481.3,3661.3,1.0318614465535194,0.04524926553859052,0.3942412752479033,0.40423790904184637,0.622872496385194,0.20560084544927154,4942]
["High","O43291","Kunitz-type protease inhibitor 2 [OS=Homo sapiens]",20,4,7,4,252,28.2,8.29,13.65,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity","SPINT2","ENSG00000167642","","MET Receptor Activation; Signaling by MST1","",292,346.5,274.2,344.4,360.5,342.7,0.8712294768995801,-0.19887532832401597,0.11603368033944961,0.9354159326481049,0.33868821536090565,0.4701999143467166,2675]
["High","O43293-1","Death-associated protein kinase 3 [OS=Homo sapiens]",26,8,16,8,454,52.5,6.89,29.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","DAPK3","ENSG00000167657; ENSPTRG00000010286","Bladder cancer","Caspase activation via Dependence Receptors in the absence of ligand","Autophagy; Pathways in cancer; Bladder cancer",513.3,517.6,510.6,419.8,395.1,385.5,1.284155281572809,0.3608196653962491,4.0019955428352393E-4,3.3977233993887475,0.026039650998714626,1.5843648407777369,120]
["High","O43295","SLIT-ROBO Rho GTPase-activating protein 3 [OS=Homo sapiens]",2,2,2,2,1099,124.4,6.68,6.04,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity","SRGAP3","ENSG00000196220","","CDC42 GTPase cycle; RAC1 GTPase cycle; Inactivation of CDC42 and RAC1","Axon guidance",61.5,55.7,67.8,63.1,69.8,61,0.9541000515729756,-0.06778753270311819,0.5360033481849343,0.27083249744584975,0.7192153536050812,0.14314104998062516,5819]
["High","O43296","Zinc finger protein 264 [OS=Homo sapiens]",3,1,1,1,627,70.5,7.49,4.98,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF264","ENSG00000083844","","Generic Transcription Pathway","",28.7,25.7,24.3,16.3,8.2,20.5,1.748888888888889,0.8064386342904494,0.04288040020477709,1.3677411700056958,0.20667294123388857,0.6847163798896914,1620]
["High","O43298","Zinc finger and BTB domain-containing protein 43 [OS=Homo sapiens]",4,2,2,2,467,52.6,5.76,2.27,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB43","ENSG00000169155","","","",122.3,82.1,119,119.2,88.7,117.7,0.9932432432432431,-0.009781020792585608,0.9661998550132936,0.014933032019165,0.9812810182028872,0.00820660202101856,7688]
["High","O43301","Heat shock 70 kDa protein 12A [OS=Homo sapiens]",8,4,7,4,675,74.9,6.77,0,"","nucleus;other cell component","other molecular function","HSPA12A","ENSG00000165868","","Regulation of HSF1-mediated heat shock response","",292.7,155.7,304.5,253.4,327.5,283.3,0.8712103679703772,-0.19890697172046376,0.5178689414667584,0.28578013446207134,0.7083953565123423,0.14972429424604528,5708]
["High","O43303","centriolar coiled-coil protein of 110 kDa [OS=Homo sapiens]",6,4,4,4,1012,113.4,8.65,8.68,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cell component","","CCP110","ENSG00000103540","Joubert syndrome","Ub-specific processing proteases; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; RHOV GTPase cycle","",192.3,199.9,170.8,181.1,169.7,163.8,1.0940536338904006,0.1296834652337923,0.18492100090276692,0.7330137645667906,0.42441598325949564,0.3722082691847054,3402]
["High","O43310","CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",10,4,4,4,598,67.5,6.54,5.41,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","CTIF","ENSG00000134030; ENSG00000282825","","","",79.6,96.9,93.2,97.1,85.8,75.9,1.0421174652241114,0.05951790424309616,0.6759756079737906,0.1700689749363353,0.8130033190171531,0.08990768143189413,6492]
["High","O43314-1","inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 [OS=Homo sapiens]",12,12,15,12,1243,140.3,8.22,33.34,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","PPIP5K2","ENSG00000145725","","Synthesis of pyrophosphates in the cytosol","Phosphatidylinositol signaling system",733.8,604.4,688.3,722.5,718.4,706.1,0.9438751746623194,-0.08333201581193267,0.35256292179615795,0.4527633633527703,0.5899724160703818,0.22916829315186868,4666]
["High","O43318","mitogen-activated protein kinase kinase kinase 7 [OS=Homo sapiens]",5,4,5,4,606,67.2,7.11,2.45,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","signal transduction activity or receptor binding;kinase activity;other molecular function","MAP3K7","ENSG00000135341","IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL-6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway","Downstream TCR signaling; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway","MAPK signaling pathway; NF-kappa B signaling pathway; Autophagy; AMPK signaling pathway; Wnt signaling pathway; Osteoclast differentiation; Adherens junction; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; T cell receptor signaling pathway; TNF signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Leishmaniasis; Toxoplasmosis; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",337.9,334.9,367.9,348.8,298.1,347.2,1.046876571773463,0.066091356512056,0.47440011627126255,0.3238552132020536,0.6774169911934927,0.16914391443920285,5468]
["Low","O43323","desert hedgehog protein [OS=Homo sapiens]",2,1,1,1,396,43.6,9.28,0,"cell-cell signaling;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","DHH","ENSG00000139549","Hedgehog signaling pathway; Hedgehog signaling pathway; Somatic sex determination; Mammalian disorder of sexual development","Release of Hh-Np from the secreting cell; Activation of SMO; Class B/2 (Secretin family receptors); Ligand-receptor interactions; HHAT G278V doesn't palmitoylate Hh-Np; Transcriptional regulation of testis differentiation","Hedgehog signaling pathway",34.2,37.1,32.2,51.5,36.8,40.4,0.8041958041958044,-0.31438128583401387,0.14493923090634744,0.8388140475162611,0.3752272927442841,0.4257055800553621,3016]
["High","O43324-1","Eukaryotic translation elongation factor 1 epsilon-1 [OS=Homo sapiens]",43,6,18,6,174,19.8,8.54,38.05,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EEF1E1","ENSANAG00000036153; ENSG00000124802; ENSPTRG00000017709","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","",643.5,597,765.3,853.7,813.5,818.1,0.807065545406993,-0.30924224890151264,0.03665014949432766,1.4359242495513889,0.1929631606552329,0.7145255959211356,1483]
["High","O43347","RNA-binding protein Musashi homolog 1 [OS=Homo sapiens]",25,7,21,6,362,39.1,7.85,39.55,"developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MSI1","ENSG00000135097","","Regulation of expression of SLITs and ROBOs","mRNA surveillance pathway",802.3,712.2,896.7,971.5,1065.2,1009.4,0.7915695479465545,-0.33721198259231366,0.024052832061833788,1.6188337809776832,0.1605166775545284,0.7944798380652095,1170]
["Medium","O43353-1","Receptor-interacting serine/threonine-protein kinase 2 [OS=Homo sapiens]",1,1,1,1,540,61.2,7.09,2.02,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","RIPK2","ENSG00000104312","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor (TCR) signaling pathway","Downstream TCR signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases","NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Shigellosis; Salmonella infection; Tuberculosis",33.2,32.1,40.5,48.8,48.9,40.7,0.7644508670520234,-0.38750431552269843,0.04543586140278268,1.3426012338945277,0.21307099449425057,0.671475667078231,1665]
["High","O43379-1","Wd repeat-containing protein 62 [OS=Homo sapiens]",4,5,6,1,1518,165.8,5.91,8.62,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;nucleus","","WDR62","ENSG00000075702","","","",174,184.4,179,185.9,166.1,167,1.0354527938342968,0.050261782767923,0.43755423948213734,0.3589681039039969,0.6532358512192215,0.18492998811263578,5230]
["High","O43390-1","heterogeneous nuclear ribonucleoprotein r [OS=Homo sapiens]",58,28,215,20,633,70.9,8.13,525.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","Hnrnpr; HNRNPR; LOC111154612","ENSAMEG00000009537; ENSCAFG00000013308; ENSCANG00000026442; ENSCATG00000035305; ENSFCAG00000019123; ENSG00000125944; ENSG00000282958; ENSGGOG00000013250; ENSLCNG00005013650; ENSMFAG00000039737; ENSMMUG00000010970; ENSMPUG00000015898; ENSNLEG00000008411; ENSRROG00000036942; ENSSSUG00005005658; ENSUAMG00000027050; ENSUMAG00000013292","mRNA Processing; mRNA processing","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","",4518,4256.3,4553.9,4761.6,4992.2,4991.2,0.9039131909121735,-0.1457438676607358,0.017572970247162326,1.7551548262719605,0.1421862711811849,0.8471423349571178,965]
["High","O43395","U4/U6 small nuclear ribonucleoprotein Prp3 [OS=Homo sapiens]",42,25,86,25,683,77.5,9.5,169.89,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","PRPF3","ENSG00000117360","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",3849.7,3646.1,3608.7,3873.6,3555.1,3684.2,0.999244121696407,-0.001090914231269448,0.9823555347781452,0.007731303610813633,0.9902184373286544,4.2689916022421925E-3,7746]
["High","O43396","Thioredoxin-like protein 1 [OS=Homo sapiens]",52,12,49,12,289,32.2,4.96,135.55,"","cytosol;nucleus;other cell component","other molecular function","TXNL1","ENSG00000091164","","RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle","",2029,2518.7,1950.7,2071.4,1957.1,2049.9,1.069097130823901,0.0963929323775193,0.482755213420778,0.31627302744468366,0.6849632393947728,0.1643327355972048,5503]
["High","O43399","Tumor protein D54 [OS=Homo sapiens]",60,9,25,9,206,22.2,5.36,49.43,"other metabolic processes;other biological processes","other cell component","other molecular function","TPD52L2","ENSG00000101150","","","",854.3,1118.1,944.2,993.1,939.7,867.2,1.041642857142857,0.05886071279004654,0.6733156822240258,0.17178127024311418,0.8110535092263489,0.09095049228066994,6482]
["High","O43402","ER membrane protein complex subunit 8 [OS=Homo sapiens]",42,7,21,7,210,23.8,6.4,44.2,"cell organization and biogenesis","other membranes;cytosol;ER/Golgi;other cell component","","EMC8","ENSG00000131148","","","",634.8,573.2,575.5,585.8,572.6,592.9,1.01838634157483,0.02628497530006426,0.6365025435233465,0.19619985652572747,0.7867360867231739,0.10417092876146003,6317]
["High","O43414-1","ERI1 exoribonuclease 3 [OS=Homo sapiens]",3,1,4,1,337,37.2,8.07,8.71,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","ERI3","ENSG00000117419; ENSMFAG00000044436; ENSMLEG00000012810; ENSMMUG00000011651; ENSMNEG00000035539; ENSNLEG00000014004; ENSPANG00000013867; ENSPPAG00000042776; ENSPTRG00000000655; ENSRBIG00000044795; ENSRROG00000036414","","","",234.3,218.5,247.8,266.2,249,263.1,0.9001670307079532,-0.1517353689832404,0.0604372811521218,1.21869508118261,0.24501261227194548,0.6108115593124904,1926]
["High","O43422-1","52 kDa repressor of the inhibitor of the protein kinase [OS=Homo sapiens]",10,4,6,4,761,87.6,5.86,13.15,"other metabolic processes;signal transduction;other biological processes","","nucleic acid binding activity;kinase activity;other molecular function","THAP12","ENSG00000137492; ENSPTRG00000004091","","","",76.2,58.2,82.2,73.1,74.9,76.1,{"$f":"AVERAGE(T386:V386)/AVERAGE(W386:Y386)","v":0.9665327978580991},{"$f":"LOG(Z386,2)","v":-0.04910940590206609},{"$f":"TTEST(T386:V386,W386:Y386,2,2)","v":0.7480424488780879},{"$f":"-LOG10(AB386)","v":0.12607375669377952},{"$f":"AB386*7808/AF386","v":0.8552812184565983},{"$f":"-LOG10(AD386)","v":0.06789106475354921},6829]
["High","O43426","Synaptojanin-1 [OS=Homo sapiens]",6,7,8,7,1573,173,7.42,17.28,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ1","ENSG00000159082","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway","Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Clathrin-mediated endocytosis; Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",227.3,195.4,226,187.9,200.1,207.7,1.0889709585361758,0.12296547973478572,0.2122089908000038,0.6732362200005932,0.4534558840083278,0.3434649583584768,3654]
["High","O43427","Acidic fibroblast growth factor intracellular-binding protein [OS=Homo sapiens]",23,8,15,8,364,41.9,6.48,25.79,"signal transduction","other membranes;mitochondrion;nucleus;other cell component","other molecular function","FIBP","ENSG00000172500","Modulators of TCR signaling and T cell activation","","",787.7,707.7,803.8,770.4,804.5,753.4,0.9875016106171884,-0.018144993669717033,0.7852959401701187,0.10496664776131864,0.879711721785981,0.055659621200692615,6970]
["High","O43432","Eukaryotic translation initiation factor 4 gamma 3 [OS=Homo sapiens]",23,32,66,25,1585,176.5,5.38,113.78,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","nucleic acid binding activity","EIF4G3","ENSG00000075151","Translation factors; Translation inhibitors in chronically activated PDGFRA cells","ISG15 antiviral mechanism","Viral myocarditis",1627,1493.5,1599,1667.7,1591.8,1654.6,0.9603996662664577,-0.058293192647448366,0.23892631534643916,0.6217360144177605,0.486196682362522,0.3131880089574414,3837]
["High","O43439","Protein CBFA2T2 [OS=Homo sapiens]",3,2,4,2,604,67.1,8.05,10.01,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","other molecular function","CBFA2T2","ENSG00000078699","","","",228.4,241.5,234.7,241.9,222.5,215.1,1.0369389256806474,0.052330923840209896,0.3975510408549634,0.40060710514933173,0.6255700376855208,0.20372406042688665,4962]
["High","O43447","peptidyl-prolyl cis-trans isomerase H [OS=Homo sapiens]",52,9,51,8,177,19.2,8.07,58.75,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PPIH","ENSG00000171960","","mRNA Splicing - Major Pathway","Spliceosome",1717.8,1747.5,1752.8,1774.6,1707.3,1749.7,0.9974195274868111,-3.7276465137679677E-3,0.8509934829509123,0.07007376580177475,0.9173763792462686,0.037452446343855084,7243]
["Medium","O43462","Membrane-bound transcription factor site-2 protease [OS=Homo sapiens]",2,1,1,1,519,57.4,7.49,2.45,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MBTPS2","ENSG00000012174","Sterol regulatory element-binding proteins (SREBP) signaling; Type I collagen synthesis in the context of osteogenesis imperfecta; Unfolded protein response","Regulation of cholesterol biosynthesis by SREBP (SREBF); ATF6 (ATF6-alpha) activates chaperones; CREB3 factors activate genes; Assembly of active LPL and LIPC lipase complexes","Protein processing in endoplasmic reticulum",35.5,30.8,34.9,35.7,37.9,41.9,0.8761904761904761,-0.19068356160910996,0.11129078134154057,0.9535408085162574,0.33306187072240273,0.4774750829578428,2609]
["High","O43463","Histone-lysine N-methyltransferase SUV39H1 [OS=Homo sapiens]",3,1,2,1,412,47.9,8.03,7.6,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SUV39H1","ENSG00000101945","Histone modifications; Retinoblastoma gene in cancer; Interactions between LOXL4 and oxidative stress pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","PKMTs methylate histone lysines; SIRT1 negatively regulates rRNA expression","Lysine degradation; Metabolic pathways",76.7,85.6,88.4,93,117.7,107.9,0.7868801004394226,-0.34578427069137035,0.047389812099173756,1.3243150132768335,0.21907617103040183,0.6594048581892068,1689]
["High","O43464","Serine protease HTRA2, mitochondrial [OS=Homo sapiens]",22,6,12,6,458,48.8,10.07,17.97,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HTRA2","ENSG00000115317","Apoptosis modulation and signaling; Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity","","Apoptosis; Apoptosis; Parkinson disease; Pathways of neurodegeneration",28,38.2,38.9,35.2,37.2,31.8,1.0086372360844529,0.012407391683670048,0.941768699467072,0.026055747822609724,0.9683078753540819,0.013986535967752706,7594]
["High","O43482","Protein Mis18-beta [OS=Homo sapiens]",10,2,2,2,229,24.7,7.37,2.03,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","other molecular function","OIP5","ENSG00000104147","","Deposition of new CENPA-containing nucleosomes at the centromere","",82.1,62.2,73.5,100.2,88.1,100.1,0.7552011095700417,-0.40506721052391537,0.028558847347474388,1.5442593249327456,0.17448159631383411,0.7582503740964917,1278]
["High","O43488","aflatoxin B1 aldehyde reductase member 2 [OS=Homo sapiens]",18,6,11,6,359,39.6,7.17,9.95,"other metabolic processes","cytosol;ER/Golgi","other molecular function","AKR7A2","ENSG00000053371","Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II","Aflatoxin activation and detoxification","Metabolism of xenobiotics by cytochrome P450",498.6,402.3,460.2,448.9,478.2,440.2,0.9954655159803995,-0.006556754617881469,0.9488220565954992,0.02281522812570718,0.9718486970874536,0.012401343237103526,7623]
["High","O43490-1","Prominin-1 [OS=Homo sapiens]",6,4,4,4,865,97.1,7.27,8.05,"developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","PROM1","ENSG00000007062","Extracellular vesicle-mediated signaling in recipient cells","","Transcriptional misregulation in cancer",47.1,41.7,54,55.4,57.4,54,0.8561151079136691,-0.22412330941556394,0.09625553007443562,1.0165743100083462,0.3100508163453768,0.5085671208439593,2424]
["High","O43491-1","band 4.1-like protein 2 [OS=Homo sapiens]",54,50,238,7,1005,112.5,5.44,509.23,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","EPB41L2","ENSG00000079819","Splicing factor NOVA regulated synaptic proteins","Neurexins and neuroligins","",9164.8,8989.9,8729.7,10077.3,9320.1,9736.8,0.9227780409278441,-0.11594442183898673,0.04129730041546593,1.38407833703575,0.20305372899493573,0.692389030468192,1588]
["High","O43491-4","Isoform 4 of Band 4.1-like protein 2 [OS=Homo sapiens]",54,44,189,1,852,95.5,5.77,395.37,"","","","EPB41L2","","","","",20.5,13.8,18.9,26.8,18.9,20.7,0.8012048192771082,-0.31975699584573564,0.23248791366635274,0.6335996198254145,0.4783308642705882,0.3202715953982782,3795]
["High","O43493-1","Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",26,11,21,11,480,51.1,5.73,42.75,"","","","","","","","",1065.9,929.8,1044.2,1079.1,988.1,1048.1,0.9757968734953297,-0.035347234087051205,0.6413371714402455,0.1929135879580993,0.7899606617140617,0.1023945350714397,6339]
["High","O43502","DNA repair protein RAD51 homolog 3 [OS=Homo sapiens]",5,2,2,2,376,42.2,6.74,5.99,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD51C","ENSG00000108384","DNA repair pathways, full network","Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination","Homologous recombination; Fanconi anemia pathway",42.3,33.8,43.6,48.2,49.7,47.2,0.8249483115093038,-0.2776243671232427,0.05515570095839345,1.258409591713152,0.23571741274391683,0.6276083344070543,1827]
["High","O43504","Ragulator complex protein LAMTOR5 [OS=Homo sapiens]",11,1,3,1,91,9.6,4.87,9.14,"cell organization and biogenesis;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","LAMTOR5","ENSG00000134248","","Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","mTOR signaling pathway",72.7,94.1,77.9,106.1,69.6,79.5,0.9588557993730409,-0.060614227685479506,0.7959009607850124,0.09914097103192306,0.8859986743383771,0.05256692791877138,7014]
["High","O43505","beta-1,4-glucuronyltransferase 1 [OS=Homo sapiens]",11,4,6,4,415,47.1,7.2,12.9,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B4GAT1","ENSG00000174684","","Keratan sulfate biosynthesis; Defective LARGE causes MDDGA6 and MDDGB6; O-linked glycosylation","Mannose type O-glycan biosynthesis; Metabolic pathways",328.4,348.4,325,494.9,464.1,520.2,0.6772579772850189,-0.5622226131462943,8.6342209387682079E-4,3.063776842492328,0.035859572920160725,1.4453948870973727,188]
["High","O43524","Forkhead box protein O3 [OS=Homo sapiens]",2,1,1,1,673,71.2,5.16,2.2,"RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXO3","ENSG00000118689","IL-5 signaling pathway; Energy metabolism; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Kit receptor signaling pathway; Copper homeostasis; NAD metabolism, sirtuins and aging; Imatinib and chronic myeloid leukemia; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Non-small cell lung cancer; Leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; DNA damage response (only ATM dependent)","MAPK6/MAPK4 signaling; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by NODAL; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; FoxO signaling pathway; Mitophagy; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Neurotrophin signaling pathway; Prolactin signaling pathway; Alcoholic liver disease; Shigellosis; Chemical carcinogenesis; Endometrial cancer; Non-small cell lung cancer",24.8,27.7,25.7,32.5,23.2,27.1,0.9444444444444443,-0.08246216019197317,0.616621860719062,0.20998108255896764,0.772930404317617,0.11185960877447323,6229]
["Medium","O43529","Carbohydrate sulfotransferase 10 [OS=Homo sapiens]",2,1,1,1,356,42.2,8.03,2.54,"cell adhesion;protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST10","ENSG00000115526","Metapathway biotransformation Phase I and II","Reactions specific to the complex N-glycan synthesis pathway","Mannose type O-glycan biosynthesis; Metabolic pathways",53,70.7,64.2,57.8,76.4,63.4,0.9509109311740892,-0.07261788016462194,0.6906926667491038,0.16071515497880373,0.8224688641111793,0.08488053398668366,6557]
["High","O43542","DNA repair protein XRCC3 [OS=Homo sapiens]",6,2,2,2,346,37.8,8.48,5,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","XRCC3","ENSG00000126215","Fluoropyrimidine activity; Male infertility","Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange","Homologous recombination",67.9,89.2,74.1,90.5,82.5,89,0.8824427480916032,-0.18042541392413364,0.2047929794069793,0.6886849356701819,0.44752969023501105,0.3491781472139864,3573]
["High","O43567","E3 ubiquitin-protein ligase RNF13 [OS=Homo sapiens]",6,1,2,1,381,42.8,4.98,2.91,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RNF13","ENSG00000082996","","","",49.3,55.4,50.1,49.5,59,74.2,0.8472906403940886,-0.23907116248307836,0.27963662516293813,0.5534059478602862,0.526121149222222,0.2789142399137435,4150]
["High","O43572","A-kinase anchor protein 10, mitochondrial [OS=Homo sapiens]",7,3,5,3,662,73.8,6.39,5.68,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","AKAP10","ENSG00000108599","G protein signaling pathways","Factors involved in megakaryocyte development and platelet production","",41.4,42.1,41.5,42.5,38.6,40.2,1.030502885408079,0.04334854442893907,0.3449364740829395,0.46226088027620094,0.5839687748568064,0.23361037424022701,4612]
["High","O43583","density-regulated protein [OS=Homo sapiens]",22,5,19,5,198,22.1,5.3,47.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","","nucleic acid binding activity","DENR","ENSG00000139726","","","",846.4,773.6,839.5,1191.7,808.9,788.1,0.8819521640907951,-0.18122768683759244,0.45644984678722966,0.3406069343621882,0.6646699745831199,0.1773939393504136,5362]
["High","O43592","Exportin-T [OS=Homo sapiens]",26,19,39,19,962,109.9,5.39,77.6,"transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPOT","ENSG00000184575","","tRNA processing in the nucleus","Nucleocytoplasmic transport",1244.9,1041.9,1297,1335.5,1581.2,1433.6,0.8238052548100134,-0.27962476612697024,0.07282686843103439,1.1377083643881938,0.2696217110998182,0.5692451394690448,2109]
["Medium","O43593-1","lysine-specific demethylase hairless [OS=Homo sapiens]",2,1,1,1,1189,127.4,7.08,0,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HR","ENSG00000168453","","","",32.8,39.9,38.4,35.2,37.2,39.2,0.9955197132616486,-0.006478210440095842,0.9490228344983993,0.022723337860014653,0.971926848342537,0.012366420831649247,7624]
["High","O43597","Protein sprouty homolog 2 [OS=Homo sapiens]",6,2,3,2,315,34.7,8.35,9.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","SPRY2","ENSG00000136158","Glioblastoma signaling pathways; Ectoderm differentiation; EGF/EGFR signaling pathway","EGFR downregulation; Spry regulation of FGF signaling","MicroRNAs in cancer",123,161.5,140.9,249.2,229.2,249,0.5848226560351938,-0.7739288924949448,1.4769128060671652E-3,2.830645143795487,0.043515981848197834,1.3613512130736596,265]
["High","O43598-1","2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [OS=Homo sapiens]",32,5,17,5,174,19.1,5.05,19.41,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","C6orf108; DNPH1","ENSG00000112667","","Purine catabolism","",688.5,640.2,782.5,825.4,796.7,732.7,0.8965517241379308,-0.1575412769864803,0.1794362722597565,0.7460897616823006,0.41909614531982614,0.37768633361623366,3343]
["High","O43602","Neuronal migration protein doublecortin [OS=Homo sapiens]",10,2,2,2,365,40.5,9.28,2.77,"cell organization and biogenesis;developmental processes;signal transduction","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DCX","ENSG00000077279","","Neurofascin interactions","",114.1,116.7,125,117,118.4,104.7,1.0461628932666862,0.06510750455931784,0.3916124510328511,0.40714350857242915,0.6198479662810665,0.20771481937593497,4933]
["High","O43615","Mitochondrial import inner membrane translocase subunit TIM44 [OS=Homo sapiens]",52,24,96,24,452,51.3,8.32,201.09,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus","other molecular function","TIMM44","ENSG00000104980","","Mitochondrial protein import","",3752.5,4052.2,3633.4,3735.9,3845,3829.1,1.0024627519719544,3.5486321478445226E-3,0.9456658777657889,0.02426228122424112,0.9710361880056918,0.012764584759011212,7604]
["High","O43617-1","Trafficking protein particle complex subunit 3 [OS=Homo sapiens]",42,9,25,9,180,20.3,4.96,40.56,"transport","other membranes;cytosol;ER/Golgi;other cell component","","TRAPPC3","ENSCANG00000028241; ENSCATG00000041647; ENSCSAG00000001096; ENSG00000054116; ENSGGOG00000004752; ENSMMUG00000022499; ENSMNEG00000014589; ENSPPAG00000041117; ENSPPYG00000001546; ENSRBIG00000043692; ENSRROG00000034420","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",1745.1,1159.1,1614.7,1695.5,1830.3,1640.2,0.8747386759581881,-0.19307601189518603,0.311568304303262,0.506446729325329,0.5547834253135392,0.25587652236875297,4385]
["High","O43633","charged multivesicular body protein 2a [OS=Homo sapiens]",14,3,5,3,222,25.1,5.97,7.85,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","CHMP2A","ENSG00000130724","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Endocytosis; Necroptosis",208.6,233,214.8,233.3,197.3,196.6,1.0465561224489797,0.06564967939850462,0.5295870389552033,0.276062652305356,0.7157721308918517,0.14522521518813333,5777]
["High","O43639","Cytoplasmic protein NCK2 [OS=Homo sapiens]",23,8,13,7,380,42.9,6.95,29.84,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NCK2","ENSG00000071051","Pathogenic Escherichia coli infection; Brain-derived neurotrophic factor (BDNF) signaling pathway; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; ErbB signaling pathway","RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Ephrin signaling; Activation of RAC1; Regulation of cortical dendrite branching","ErbB signaling pathway; Axon guidance; T cell receptor signaling pathway; Pathogenic Escherichia coli infection",416.3,388.5,423.3,453.9,401.6,426.9,0.9576575171553335,-0.06241829137075068,0.38247325924800213,0.41739892329990935,0.6132138004534704,0.21238807985590827,4870]
["High","O43657","Tetraspanin-6 [OS=Homo sapiens]",20,6,20,6,245,27.5,8.1,46.7,"other biological processes","plasma membrane;other membranes","","TSPAN6","ENSG00000000003","","","",567.3,1137.1,685.1,580.6,513.2,596.7,1.413487133984028,0.4992587513530884,0.2550782855630643,0.5933265106631539,0.502181354936058,0.29913941587380233,3966]
["High","O43660-1","Pleiotropic regulator 1 [OS=Homo sapiens]",37,13,32,13,514,57.2,9.17,67.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","","PLRG1","ENSG00000171566","","mRNA Splicing - Major Pathway","Spliceosome",1102.6,1036.5,1106.7,1135.3,1258.5,1225.6,0.8967784715698734,-0.15717645025448848,0.04515475096275185,1.345296548598383,0.2122626703896246,0.6731263763911419,1661]
["High","O43663-1","Protein regulator of cytokinesis 1 [OS=Homo sapiens]",24,12,21,12,620,71.6,6.68,31.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","PRC1","ENSG00000198901","","RHO GTPases activate CIT","",492.4,353,549.3,534.7,603.1,591.2,0.8066512434933486,-0.30998303728952403,0.14674996597558795,0.8334219907727917,0.37791020261787295,0.4226113830741721,3032]
["High","O43670-1","BUB3-interacting and GLEBS motif-containing protein ZNF207 [OS=Homo sapiens]",16,8,37,8,478,50.7,9.1,88.14,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","LOC111151255; Znf207; ZNF207","ENSAMEG00000005671; ENSANAG00000033773; ENSCANG00000036057; ENSCJAG00000014376; ENSECAG00000017464; ENSG00000010244; ENSGGOG00000024003; ENSMFAG00000001904; ENSMLEG00000018149; ENSMMUG00000016875; ENSMNEG00000041308; ENSNLEG00000005954; ENSOCUG00000008195; ENSPCOG00000020744; ENSPPAG00000032098; ENSPTRG00000008989; ENSRROG00000037743; ENSSBOG00000026038; ENSSTOG00000000712","","","",1191.3,1277.5,1168.4,1204.6,1095.8,1188.3,1.0425659987961133,0.060138715201836834,0.35569801740566176,0.4489185554838305,0.5922990232252948,0.22745898356404434,4689]
["High","O43674-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [OS=Homo sapiens]",21,4,13,4,189,21.7,9.63,29.64,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB5","ENSG00000136521; ENSGGOG00000005222; ENSPTRG00000015649","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",718.5,639.8,730.7,731.5,768.9,754.3,0.9265090699427863,-0.11012299548594821,0.1443240775092299,0.8406612097443249,0.3742551966762096,0.4268321605984488,3011]
["High","O43676","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [OS=Homo sapiens]",11,1,3,1,98,11.4,9.2,6.82,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB3","ENSG00000119013","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",122.4,145.2,148.1,162,139.2,155,0.9112231477422185,-0.13412369868776472,0.2702419947321727,0.5682471621115129,0.5169156038385115,0.28658035783292923,4082]
["High","O43678","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [OS=Homo sapiens]",37,3,4,3,99,10.9,9.57,6.95,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;mitochondrion","transporter activity","NDUFA2","ENSG00000131495","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",148.6,142.6,143.2,230.4,135.1,159.3,0.8277439024390244,-0.27274361681372217,0.35244209912575114,0.4529122207878325,0.5900231367868493,0.22913095788015475,4664]
["High","O43681","ATPase ASNA1 [OS=Homo sapiens]",44,10,49,10,348,38.8,4.91,98.01,"cell organization and biogenesis;transport","ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","GET3","ENSG00000198356","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",1500.1,1410.3,1510.4,1451.1,1552,1506.5,0.9803086748270354,-0.028692005328720287,0.5303956319035796,0.27540006123975264,0.7163689835501037,0.14486322595623266,5781]
["High","O43683","Mitotic checkpoint serine/threonine-protein kinase BUB1 [OS=Homo sapiens]",18,14,36,14,1085,122.3,6.47,103.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","BUB1","ENSG00000169679","Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation",1306.1,1010.5,1332.7,903.3,942.2,936.9,1.3115655549166187,0.39128991846032823,0.04985072327173614,1.3023285362360724,0.22512113782863838,0.6475837248513595,1729]
["High","O43684","Mitotic checkpoint protein BUB3 [OS=Homo sapiens]",55,13,61,13,328,37.1,6.84,138.72,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","BUB3","ENSG00000154473","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Human T-cell leukemia virus 1 infection",1956.7,1952.1,2120.6,2190.7,2426.3,2438,0.8546279234585401,-0.22663163958489302,0.02497584429733662,1.6024798217215321,0.16428929424903482,0.7843907360174879,1187]
["High","O43687-1","A-kinase anchor protein 7 isoforms alpha and beta [OS=Homo sapiens]",12,1,1,1,104,11.5,4.94,2.61,"transport;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","AKAP7","ENSG00000118507; ENSGGOG00000008778; ENSPPAG00000039914; ENSPTRG00000018599","G protein signaling pathways","","",42.2,50.9,62,59.4,64.4,51.7,0.8837606837606837,-0.1782723441558323,0.37498145692873236,0.425990207879328,0.6066836335887987,0.21703772079345957,4826]
["High","O43688","Phospholipid phosphatase 2 [OS=Homo sapiens]",7,2,6,2,288,32.6,8.35,5.2,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","PLPP2","ENSG00000141934","Triacylglyceride synthesis","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",443.5,292,400,377.2,370.8,404.1,0.98559152851315,-0.020938239244759446,0.9103965849508421,0.04076938005685384,0.9500636908976443,0.022247279260404706,7482]
["High","O43707","Alpha-actinin-4 [OS=Homo sapiens]",70,61,472,40,911,104.8,5.44,1101.64,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","ACTN4","ENSG00000130402; ENSG00000282844","Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome","Platelet degranulation ; Nephrin family interactions","Focal adhesion; Adherens junction; Tight junction; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Amoebiasis; Viral carcinogenesis; Systemic lupus erythematosus",19969.7,21442.3,19583.1,19050.5,18446.7,18438.8,1.090444436498856,0.12491625945154432,0.048643462510262324,1.312975518941331,0.222239997238226,0.6531777770034324,1709]
["Low","O43708","maleylacetoacetate isomerase [OS=Homo sapiens]",5,1,1,1,216,24.2,8.54,0,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","GSTZ1","ENSG00000100577","Metapathway biotransformation Phase I and II","Regulation of pyruvate dehydrogenase (PDH) complex; Glutathione conjugation; Tyrosine catabolism","Tyrosine metabolism; Metabolic pathways",18.9,15.6,12.1,18,15.7,13.5,0.9872881355932203,-0.018456904707561134,0.9363795073718374,0.028548099388822357,0.9660744177536081,0.014989418123923301,7568]
["High","O43709-1","Probable 18S rRNA (guanine-N(7))-methyltransferase [OS=Homo sapiens]",16,5,9,5,281,31.9,8.73,28.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","BUD23","ENSG00000071462; ENSGGOG00000001453","7q11.23 copy number variation syndrome","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",493,371.5,471.9,503.9,510.6,470.3,0.9000538793103449,-0.1519167277926018,0.27868516858350273,0.5548861434996076,0.5255975353381617,0.2793466799618712,4140]
["High","O43719","HIV Tat-specific factor 1 [OS=Homo sapiens]",50,32,81,32,755,85.8,4.4,178.62,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","HTATSF1","ENSG00000102241","","","",3773.9,3088.3,3598.3,3608.1,3296.5,3527.1,1.002760815590939,0.003977526875696,0.9681266454861066,0.01406782674314477,0.9823434500267083,0.007736646252006881,7695]
["High","O43739","cytohesin-3 [OS=Homo sapiens]",17,4,10,2,400,46.3,5.47,24.52,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","CYTH3","ENSG00000008256","Insulin signaling","Intra-Golgi traffic","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection",226.9,220.5,215.6,186.2,185.7,192,1.1757403794999113,0.2335695273865788,0.00100944500268449,2.9959173376230606,0.03844754429736829,1.4151313940201793,205]
["High","O43741","5'-AMP-activated protein kinase subunit beta-2 [OS=Homo sapiens]",22,4,6,4,272,30.3,6.46,9.93,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PRKAB2","ENSG00000131791","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Caloric restriction and aging; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Carnitine metabolism; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy",320,363.2,355.6,380.5,382.8,400.6,0.8925165392215827,-0.16404919091999856,0.04750757512893863,1.323237136177239,0.21923117411746618,0.6590976902216084,1692]
["High","O43747-1","AP-1 complex subunit gamma-1 [OS=Homo sapiens]",23,16,55,16,822,91.3,6.8,113.33,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","AP1G1","ENSCANG00000031796; ENSCCAG00000037984; ENSCJAG00000015028; ENSG00000166747; ENSGGOG00000004800; ENSMFAG00000037769; ENSMLEG00000040277; ENSMMUG00000010878; ENSMNEG00000034875; ENSPANG00000016832; ENSPPAG00000031149; ENSPTRG00000008327; ENSRBIG00000018408; ENSRROG00000025423; ENSSBOG00000025975","","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","Lysosome; Human immunodeficiency virus 1 infection",2082.6,1729.1,2222.5,2055.6,2407.8,2208.9,0.9043658108897981,-0.1450216421522687,0.2998565006421641,0.5230865315771832,0.5437249319586663,0.26462075240601624,4306]
["High","O43752","Syntaxin-6 [OS=Homo sapiens]",31,4,20,4,255,29.2,4.93,32.58,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STX6","ENSG00000135823","","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","SNARE interactions in vesicular transport",222.3,207.5,222.4,203.3,192.4,178.3,1.1362369337979095,0.18426370418541527,0.04101966887748837,1.3870078497029048,0.20232569462756106,0.6939489599066254,1583]
["High","O43760","Synaptogyrin-2 [OS=Homo sapiens]",32,3,6,3,224,24.8,4.94,14.02,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","SYNGR2","ENSG00000108639","","","",171.1,125.3,200,183.6,176.8,173.7,0.9294139674218312,-0.10560676876177776,0.5975019458637612,0.2236606760258198,0.7624277158529574,0.1178013245638332,6119]
["High","O43765","Small glutamine-rich tetratricopeptide repeat-containing protein alpha [OS=Homo sapiens]",38,11,72,11,313,34,4.87,137.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","SGTA","ENSG00000104969","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",3650.1,3586.1,3771.9,3594,3650.2,3444.9,1.0298434854197267,0.042425094722512956,0.2643942674369675,0.5777479654022892,0.5097260346044055,0.29266318395832236,4050]
["High","O43766-1","Lipoyl synthase, mitochondrial [OS=Homo sapiens]",2,1,1,1,372,41.9,8.59,2.72,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","LIAS","ENSG00000121897","","Glyoxylate metabolism and glycine degradation","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors",79.5,76.9,57.3,87.9,85.8,79,0.8456667985753858,-0.24183875628496407,0.15824233682261576,0.8006773123136697,0.392489252195357,0.4061722313420612,3148]
["Medium","O43768","alpha-endosulfine [OS=Homo sapiens]",12,2,2,2,121,13.4,7.24,2.11,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ENSA","ENSG00000143420","","MASTL Facilitates Mitotic Progression","",116.2,120.3,162.8,202.2,114.5,107.3,0.9417452830188678,-0.0865911928175137,0.8202965408019742,0.08602911986897531,0.900066805871531,0.04572525462222737,7116]
["High","O43776","Asparagine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",42,23,123,23,548,62.9,6.25,267.5,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","NARS1","ENSG00000134440","Photodynamic therapy-induced unfolded protein response","Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",5092.2,4905.3,5060.9,5124,5367,5246.1,0.9568726131244003,-0.06360122100819435,0.06754964359223802,1.170376938075447,0.2605867673755901,0.5840476415845731,2024]
["High","O43791","Speckle-type POZ protein [OS=Homo sapiens]",7,2,2,2,374,42.1,5.8,2.04,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SPOP","ENSG00000121067","mRNA processing; Hedgehog signaling pathway","Hedgehog 'on' state","Hedgehog signaling pathway",22.8,13.6,20.6,27.7,27,17.9,0.7851239669421488,-0.34900762894364656,0.28357600389917065,0.5473305217791383,0.5300841365680451,0.2756551923856241,4177]
["High","O43795","Unconventional myosin-Ib [OS=Homo sapiens]",20,21,52,21,1136,131.9,9.38,118.64,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1B","ENSG00000128641","","","Pathogenic Escherichia coli infection",2459.8,2209.4,2510.5,2328.3,2467.2,2427.8,0.9939639776833303,-0.008734526962295111,0.8934190035217054,0.0489448140794942,0.9401368705522205,0.026808914699885868,7420]
["High","O43808","peroxisomal membrane protein PMP34 [OS=Homo sapiens]",3,1,2,1,307,34.5,10.08,5.73,"other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","SLC25A17","ENSG00000100372","","Class I peroxisomal membrane protein import; Alpha-oxidation of phytanate","Peroxisome",84.6,73,72,89.1,97.2,97.9,0.8078817733990147,-0.3077839125670927,0.02101659577837269,1.6774376286692532,0.1529334388047847,0.8154975459765689,1073]
["High","O43809","Cleavage and polyadenylation specificity factor subunit 5 [OS=Homo sapiens]",65,13,76,13,227,26.2,8.82,166.08,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT21","ENSG00000167005","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",3895.9,3693.4,3863.9,3657.9,4132.9,3847,0.984137895478527,-0.02306761754971681,0.7057746757076542,0.15133392885751432,0.8318020630830738,0.07998000680772437,6625]
["High","O43813","LanC-like protein 1 [OS=Homo sapiens]",22,7,17,7,399,45.3,7.75,32.8,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LANCL1","ENSG00000115365","","","Glutathione metabolism; Metabolic pathways",670.5,681.3,697.8,678.4,721.1,760.4,0.9489328209639334,-0.07562213861332288,0.21493686626801847,0.6676890873303735,0.45740720954502273,0.3396969944276859,3669]
["High","O43815","striatin [OS=Homo sapiens]",33,19,37,19,780,86.1,5.27,61.18,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STRN","ENSG00000115808","","PIP3 activates AKT signaling; Extra-nuclear estrogen signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins","",1580.8,1474.2,1537.1,1679.3,1549.4,1603.6,0.9502928212238481,-0.07355596393416147,0.17582805559010975,0.7549118265555752,0.4146377100717539,0.3823312026490081,3311]
["High","O43818","U3 small nucleolar RNA-interacting protein 2 [OS=Homo sapiens]",28,11,31,11,475,51.8,7.85,70.76,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RRP9","ENSG00000114767","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1644.6,1531.1,1702.7,1594.1,1833.6,1732.1,{"$f":"AVERAGE(T450:V450)/AVERAGE(W450:Y450)","v":0.9454630024419551},{"$f":"LOG(Z450,2)","v":-0.08090709069207473},{"$f":"TTEST(T450:V450,W450:Y450,2,2)","v":0.335552798982499},{"$f":"-LOG10(AB450)","v":0.47423913420550634},{"$f":"AB450*7808/AF450","v":0.5763300163782121},{"$f":"-LOG10(AD450)","v":0.23932876093582295},4546]
["High","O43819","Protein SCO2 homolog, mitochondrial [OS=Homo sapiens]",30,5,9,5,266,29.8,8.85,18.75,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO2","ENSG00000284194","","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Central carbon metabolism in cancer",163.9,152.3,174.8,156.1,173.1,160.3,1.0030643513789583,0.004414164710998354,0.954672004674672,0.020145812737888003,0.9750266857422941,0.01098349782759153,7645]
["High","O43822","Protein C21orf2 [OS=Homo sapiens]",7,2,2,2,256,28.3,7.34,2.19,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","","CFAP410","ENSG00000160226","Ciliopathies","","",58,53.5,69.2,58.4,55.4,41.4,1.1643041237113403,0.21946794867747205,0.29240602452992104,0.534013683721198,0.5368225345708026,0.2701692617765858,4253]
["High","O43823","A-kinase anchor protein 8 [OS=Homo sapiens]",39,16,37,16,692,76.1,5.15,103.33,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","mitochondrion;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","AKAP8","ENSG00000105127","G protein signaling pathways","","",1454.8,1381,1316.2,1584.8,1430.7,1430.2,0.933936163033943,-0.09860415354110634,0.20758716486596335,0.682799502462359,0.4496090383560171,0.3471649668591715,3605]
["High","O43824","Putative GTP-binding protein 6 [OS=Homo sapiens]",8,4,6,4,516,56.8,9.42,7.75,"","","","","","","","",195.6,200.5,217,183.3,174.6,215.9,1.0684907633321716,0.09557443654010324,0.406616801100362,0.3908146806059253,0.632821204503015,0.19871897697504143,5017]
["High","O43829","Zinc finger and BTB domain-containing protein 14 [OS=Homo sapiens]",15,3,3,3,449,50.9,6.04,3.57,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB14","ENSG00000198081","","","",22.9,26.6,23.6,21.6,26.1,26.2,0.9891745602165085,-0.015702958193714006,0.8948612427848437,0.04824430118095927,0.9405137412389365,0.026634854871019655,7429]
["High","O43837-1","isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [OS=Homo sapiens]",17,5,13,5,385,42.2,8.46,27.69,"other metabolic processes","mitochondrion","other molecular function","IDH3B","ENSG00000101365","TCA cycle (aka Krebs or citric acid cycle)","Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids",333.6,212.6,319.9,324.4,294.1,319.8,0.9230523286795268,-0.11551565699844936,0.574312946759685,0.2408513932906378,0.7467502894753739,0.12682460037092727,6005]
["High","O43847-1","Nardilysin [OS=Homo sapiens]",36,39,93,39,1150,131.5,5,209.19,"","","","","","","","",3933.7,3718,3987.8,3793.3,3967,3930.7,0.9955949020614148,-0.006369251862051299,0.8693591038672477,0.06080079361669315,0.9280770963898647,0.03241594496008328,7314]
["High","O43852","Calumenin [OS=Homo sapiens]",73,26,176,7,315,37.1,4.64,391.11,"","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","CALU","ENSG00000128595","NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling pathway","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",8924.3,9378.7,8332.7,10551.8,8076.1,7597.3,1.0156528834861127,0.022407420969314865,0.8940205412219232,0.048652502639376254,0.9400097476246669,0.02686764287088092,7426]
["High","O43852-4","Isoform 4 of Calumenin [OS=Homo sapiens]",63,21,133,2,323,38.1,4.58,265.73,"","","","CALU","","","","",423.5,321.9,429.3,547.2,412.9,369.4,0.8835652500940203,-0.17859141510643206,0.46446798292846164,0.33304421776664594,0.6710891951712489,0.1732197534580035,5404]
["High","O43861-1","Probable phospholipid-transporting ATPase IIB [OS=Homo sapiens]",2,2,2,2,1147,129.2,7.61,2.23,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP9B","ENSG00000166377","","Ion transport by P-type ATPases","",94.1,102.5,92.2,96,92.7,93.8,1.0223008849557522,0.031819874697258596,0.5602561367253991,0.2516133777533983,0.7371890656474411,0.132421115075586,5934]
["High","O43865","S-adenosylhomocysteine hydrolase-like protein 1 [OS=Homo sapiens]",45,23,64,12,530,58.9,6.89,117.82,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","AHCYL1","ENSG00000168710","Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways","Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation","Cysteine and methionine metabolism; Metabolic pathways",2086.2,2226.2,2041,1993.9,2040.8,2104.2,1.0349411132287543,0.04954868263306807,0.32820692993109785,0.4838522532675018,0.5688434425975609,0.24500724392394818,4505]
["High","O43896","Kinesin-like protein KIF1C [OS=Homo sapiens]",8,8,13,3,1103,122.9,6.9,28.39,"transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1C","ENSG00000129250","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",90,72.8,72.7,81.3,81.6,97.8,0.9033371691599541,-0.14666352303541064,0.34882308434944065,0.4573947821286809,0.5868585741435968,0.23146654588907548,4641]
["High","O43909","exostosin-like 3 [OS=Homo sapiens]",9,8,9,8,919,104.7,6.51,23.42,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","EXTL3","ENSG00000012232","Proteoglycan biosynthesis","XBP1(S) activates chaperone genes","Glycosaminoglycan biosynthesis; Metabolic pathways",509.2,478.8,538.3,497.7,551.4,500,0.985281776515396,-0.02139172113383317,0.772277245264557,0.1122267612274401,0.8701213176083205,0.06042019118061146,6930]
["High","O43913","Origin recognition complex subunit 5 [OS=Homo sapiens]",12,7,17,7,435,50.3,7.74,26.53,"DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC5","ENSG00000164815","Cell cycle; G1 to S cell cycle control; DNA replication","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle",1217.8,956.3,1219.4,1236.4,1337.1,1322,0.871133359003979,-0.1990345016128483,0.14598652211741198,0.8356872376417761,0.37656516838214493,0.4241598539397136,3027]
["High","O43924","Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [OS=Homo sapiens]",29,3,5,3,150,17.4,5.67,9.61,"other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PDE6D","ENSG00000156973","Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies","ARL13B-mediated ciliary trafficking of INPP5E; RAS processing","Purine metabolism; Metabolic pathways",145.3,135.1,152.2,132.5,183.4,157.9,0.9130434782608696,-0.1312445332782525,0.42594394937695684,0.37064754661994936,0.6475409573082709,0.1887327570221108,5136]
["High","O43929","origin recognition complex subunit 4 [OS=Homo sapiens]",22,8,13,8,436,50.3,8,29.82,"DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC4","ENSG00000115947","Cell cycle; G1 to S cell cycle control; DNA replication","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle",497,401.7,488.4,508.4,598.9,555.5,0.8341953331729612,-0.2615428536588554,0.08377025935951822,1.0769101399445744,0.2883942614987294,0.5400133855068079,2268]
["High","O43933","Peroxisome biogenesis factor 1 [OS=Homo sapiens]",7,10,13,10,1283,142.8,6.33,32.41,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","PEX1","ENSG00000127980","","Peroxisomal protein import","Peroxisome",572.9,558.2,585.5,566.5,598.5,566,0.9916811091854418,-0.01205182120966203,0.737075242860624,0.13248817578924835,0.8502117737118854,0.07047288522787144,6769]
["High","O60216","Double-strand-break repair protein rad21 homolog [OS=Homo sapiens]",50,23,72,23,631,71.6,4.65,170.12,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RAD21","ENSG00000164754","Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin","Cell cycle",1632.1,2377.4,1619.7,1829.1,1786.6,1720.3,1.0549475262368815,0.07717124014519004,0.7184398237065125,0.1436096023755036,0.8391291164548166,0.07617120931487144,6685]
["High","O60231","Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [OS=Homo sapiens]",23,22,50,22,1041,119.2,6.8,112.69,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DHX16","ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",1986.3,1934.7,1920.9,2100.8,1996.7,2018.3,0.9552143627979985,-0.06610356546464712,0.07134897552648034,1.1466122583782155,0.2671907918037211,0.5731785130293564,2085]
["High","O60232","Sjoegren syndrome/scleroderma autoantigen 1 [OS=Homo sapiens]",19,2,2,2,199,21.5,5.24,7.53,"cell cycle OR cell proliferation;other biological processes","","","ZNRD2","ENSG00000173465","","","",75.2,95.9,92,109.5,73.5,69,1.0440476190476191,0.06218751477861051,0.8086448413420424,0.09224217963918602,0.8926762224231114,0.04930603306299773,7073]
["High","O60244","Mediator of RNA polymerase II transcription subunit 14 [OS=Homo sapiens]",5,6,8,6,1454,160.5,8.73,11.51,"other biological processes","nucleus","other molecular function","MED14","ENSG00000180182","Vitamin D in inflammatory diseases","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",257.4,240.4,265.5,279.2,301.5,308.1,0.8587983798379836,-0.219608625397606,0.02171544104602851,1.6632313455828351,0.15498552439432414,0.8097088629216117,1094]
["High","O60256-1","Phosphoribosyl pyrophosphate synthase-associated protein 2 [OS=Homo sapiens]",37,11,32,10,369,40.9,7.44,86.18,"other metabolic processes;other biological processes","other cell component","enzyme regulator activity;other molecular function","PRPSAP2","ENSG00000141127","","","",860.9,855.9,910.1,933.7,1001.1,895.3,0.9282004169463975,-0.10749174932241101,0.12848087195503843,0.8911615246496357,0.3548562604262257,0.44994752848051994,2827]
["High","O60264","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 [OS=Homo sapiens]",51,55,207,40,1052,121.8,8.09,440.83,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCA5","ENSG00000153147","","Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression","",9064.9,8950.1,8828.1,9522.2,9921.9,9937.6,0.9135992811852275,-0.13036657929049844,5.1181223318535985E-3,2.290889337945893,0.07611866508021504,1.1185088366932145,525]
["High","O60268-1","Uncharacterized protein KIAA0513 [OS=Homo sapiens]",6,2,2,2,411,46.6,5.06,5.53,"","other cell component","","KIAA0513","ENSG00000135709","","","",219,226.5,209.5,142.8,130.2,152.6,1.5390037593984962,0.6219967558109853,7.1484652556960107E-4,3.1457871893217,0.03264047761197336,1.4862434950552186,171]
["High","O60271-2","Isoform 2 of C-Jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",27,31,84,27,1311,145,5.19,198.73,"","","","SPAG9","","","","",4267.8,3607.9,4247.1,3546.6,3551.8,3381.1,1.1568109165513625,0.2101530718382201,0.07057527685089514,1.15134740953839,0.2660800394262623,0.5749877037732072,2071]
["High","O60281-1","zinc finger protein 292 [OS=Homo sapiens]",7,12,13,12,2723,304.6,7.39,11.68,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF292","ENSG00000188994","","","",201.8,283,214.7,204.6,200.9,200.2,1.15486214297507,0.20772064599948611,0.28299726991341473,0.5482177541126644,0.5298903317707295,0.2758140044277865,4170]
["High","O60282-1","kinesin heavy chain isoform 5C [OS=Homo sapiens]",46,39,132,24,957,109.4,6.19,281.38,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF5C","ENSG00000168280; ENSPPAG00000031052; ENSPTRG00000012521","Alzheimer's disease and miRNA effects; Alzheimer's disease","Insulin processing","Endocytosis; Dopaminergic synapse; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Salmonella infection; Non-small cell lung cancer",4004.9,3802.3,3776.9,3605.2,3293.6,3436.1,1.1208719968262877,0.16462153230201165,0.022584693742715295,1.6461857942657745,0.15730712644346212,0.8032516022021123,1121]
["High","O60287","nucleolar pre-ribosomal-associated protein 1 [OS=Homo sapiens]",15,23,35,23,2271,254.2,6.47,67.46,"RNA metabolism OR transcription;other metabolic processes","nucleus","","URB1","ENSG00000142207","","","",1093.4,969.9,1072.6,944,960.7,974.5,1.089156710197277,0.1232115470381896,0.09433046181859055,1.025348039357795,0.3074007704004821,0.5122950484164331,2396]
["Low","O60290-1","Zinc finger protein 862 [OS=Homo sapiens]",1,1,2,1,1169,131.6,7.23,0,"other biological processes","nucleus","other molecular function","ZNF862","ENSG00000106479","","","",17.9,12.4,14.7,12.9,11.6,16.5,1.0975609756097562,0.13430109171159113,0.5714576977666552,0.2430159127865964,0.7437809141793705,0.12855497006541602,5999]
["High","O60291-1","E3 ubiquitin-protein ligase MGRN1 [OS=Homo sapiens]",22,7,9,7,552,60.7,5.15,21.71,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGRN1","ENSG00000102858","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis; Hedgehog signaling pathway",175.2,173.5,204.8,166.8,210.7,213.2,0.9370238699847638,-0.09384229495379529,0.5325120881266378,0.27367052920920765,0.7174899713706278,0.144184164850187,5795]
["High","O60293","Zinc finger C3H1 domain-containing protein [OS=Homo sapiens]",11,16,21,16,1989,226.2,8.13,32.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","ZFC3H1","ENSG00000133858","","","",505.9,469.9,523.4,687.2,655.2,659.3,0.7489633811260428,-0.4170329117965784,8.566186121259405E-4,3.0672124937314424,0.03576726269240291,1.446514295609306,187]
["High","O60294","tRNA wybutosine-synthesizing protein 4 [OS=Homo sapiens]",3,2,3,2,686,75.6,6.73,3.23,"RNA metabolism OR transcription;other metabolic processes","other cell component","other molecular function","LCMT2","ENSG00000168806","","Synthesis of wybutosine at G37 of tRNA(Phe)","",86.5,99.2,88.7,77.9,90.5,80.4,1.102893890675241,0.1412939960422096,0.19536200719987032,0.7091598913222598,0.4368231821926081,0.35969432169715654,3492]
["High","O60299-1","Leucine zipper putative tumor suppressor 3 [OS=Homo sapiens]",4,2,2,2,673,71.7,7.64,6.26,"other biological processes","cytoskeleton;other cell component","","LZTS3","ENSG00000088899; ENSGGOG00000008647; ENSPTRG00000013192","","","",29.9,12.2,25.6,28,22.7,22.6,0.923601637107776,-0.11465736455881556,0.756470642302842,0.12120792174955537,0.8601314657201966,0.06543516448512533,6867]
["High","O60306","Intron-binding protein aquarius [OS=Homo sapiens]",15,18,39,17,1485,171.2,6.37,84.98,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","AQR","ENSG00000021776","","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","Spliceosome",1468.9,1133.6,1459.4,1522.1,1745.8,1568.6,0.8398428615734519,-0.2518086765625806,0.11711576252485231,0.9313846496170227,0.34032001257686895,0.4681125113915558,2687]
["High","O60307","Microtubule-associated serine/threonine-protein kinase 3 [OS=Homo sapiens]",4,5,9,3,1309,143,8.06,4.49,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","","kinase activity;other molecular function","MAST3","ENSG00000099308","","","",266,296.9,278.8,343.5,317.8,310.8,0.8658574220759182,-0.20779861427574,0.03145534420625585,1.5023055581006677,0.18179372876568886,0.7404211024640629,1351]
["High","O60313-2","Isoform 2 of Dynamin-like 120 kDa protein, mitochondrial [OS=Homo sapiens]",36,30,78,30,997,115.8,7.87,168.46,"","","","OPA1","","","","",3278.3,2968.3,3421.2,3953.8,4293.4,4203.4,0.7764926991470291,-0.3649557349288647,5.2414466895102695E-3,2.280548827032222,0.07692709727762441,1.1139206546686347,532]
["High","O60318","Germinal-center associated nuclear protein [OS=Homo sapiens]",13,16,20,16,1980,218.3,6.39,57.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3AP","ENSG00000160294","","","",845.5,739.8,813.7,831,810.1,877.9,0.9523620484319174,-0.07041796444080668,0.3425237365960457,0.46530932690007376,0.5826634717520534,0.23458220777869954,4590]
["High","O60331","Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [OS=Homo sapiens]",6,4,4,4,668,73.2,5.29,9.33,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIP5K1C","ENSG00000186111","B cell receptor signaling pathway; Focal adhesion; Regulation of actin cytoskeleton","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer",248.6,193,241.4,185.1,183.5,192.6,1.2170349251603705,0.28337056955755346,0.08328682078317466,1.07942371544762,0.2879997770925721,0.5406078483779337,2258]
["High","O60333","Kinesin-like protein KIF1B [OS=Homo sapiens]",14,21,40,2,1816,204.3,5.6,93.91,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1B","ENSG00000054523","Intracellular trafficking proteins involved in CMT neuropathy","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",555.9,574.7,577.3,618.4,614.4,596.1,0.933840013122642,-0.09875268846955144,0.013784581453245607,1.8606064160148952,0.1261782086599551,0.8990156425237827,853]
["High","O60333-3","Isoform 3 of Kinesin-like protein KIF1B [OS=Homo sapiens]",21,19,33,4,1153,130.3,8.43,68.92,"","","","KIF1B","","","","",190.9,165.4,194.2,263.3,233.3,229.8,0.7578469162995594,-0.4000216388391839,0.013808415170285705,1.8598561637310151,0.12595339445045653,0.8997901237495329,856]
["High","O60337","E3 ubiquitin-protein ligase MARCH6 [OS=Homo sapiens]",2,2,2,2,910,102.5,6.28,2.75,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","MARCHF6","ENSG00000145495","","ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",128.3,126,131.5,146.6,134,151.4,0.8930555555555555,-0.1631781690017275,0.04700390791118714,1.3278660332619352,0.21806685262658893,0.6614103445791237,1683]
["High","O60341","Lysine-specific histone demethylase 1A [OS=Homo sapiens]",59,30,92,30,852,92.8,6.52,245.15,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM1A","ENSG00000004487","Androgen receptor signaling pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects","Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Thermogenesis",3442.5,3112.1,3293.7,3322.6,3201.8,3453.3,0.9870310793068542,-0.018832582388116977,0.7374406454935785,0.13227292907449012,0.8503820056142166,0.0703859382132792,6771]
["High","O60343-1","TBC1 domain family member 4 [OS=Homo sapiens]",13,14,26,14,1298,146.5,7.01,51.72,"transport;other biological processes","cytosol;other cell component","enzyme regulator activity","TBC1D4","ENSG00000136111","Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane","Thyroid hormone signaling pathway; Insulin resistance; Diabetic cardiomyopathy",689.4,631.7,655.1,691.9,672.4,683.8,0.9648942922708852,-0.051557196413339945,0.2468129571931808,0.6076320444370643,0.49578481342020986,0.30470678040969534,3887]
["High","O60344-1","Endothelin-converting enzyme 2 [OS=Homo sapiens]",5,3,8,3,883,99.7,5.1,11.83,"protein metabolism;other metabolic processes;developmental processes","plasma membrane;other membranes;ER/Golgi","other molecular function","EEF1AKMT4-ECE2","ENSG00000284917","","","",205.6,231.2,204,189.7,184.9,179,1.157514450867052,0.21103020477198556,0.035795515785718234,1.4461713753532177,0.1916950529868916,0.7173890946765381,1458]
["High","O60353-1","Frizzled-6 [OS=Homo sapiens]",7,4,5,4,706,79.2,7.96,6.4,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","FZD6","ENSG00000164930","Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","Class B/2 (Secretin family receptors); Ca2+ pathway; PCP/CE pathway; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",204.7,221.6,198.8,171.1,179.8,189.8,1.156093952284076,0.20925864609682754,0.03197851630776929,1.4951416898798537,0.18278788823650263,0.7380525845667322,1366]
["High","O60427","Fatty acid desaturase 1 [OS=Homo sapiens]",4,2,4,2,444,51.9,8.87,7.33,"cell-cell signaling;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","FADS1","ENSG00000149485","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection","PPARA activates gene expression; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism",387,311.6,393.5,405.9,428.4,423.4,0.8683310805438499,-0.20368287112612343,0.1118533843442164,0.9513508709345223,0.3337222869543912,0.47661478891576786,2617]
["High","O60437","periplakin [OS=Homo sapiens]",29,51,83,51,1756,204.6,5.6,173.43,"cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PPL","ENSG00000118898","","Formation of the cornified envelope; Butyrophilin (BTN) family interactions","",4904.2,4043.4,4414.9,3553.2,3262.4,3223,1.331111908034985,0.4126318652996275,0.014835227876986672,1.8287057783017886,0.13044308475620714,0.8845789394217543,888]
["High","O60443","Non-syndromic hearing impairment protein 5 [OS=Homo sapiens]",9,4,7,4,496,54.5,5.17,20.01,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","transporter activity;other molecular function","GSDME","ENSG00000105928","","Regulation of TLR by endogenous ligand; Release of apoptotic factors from the mitochondria; Pyroptosis; Defective pyroptosis","",265.5,239.6,284.3,244.5,300.8,270.2,0.9679950950337219,-0.04692835770614288,0.6972548342331258,0.15660846598483447,0.8266270491485342,0.08269038770208806,6586]
["High","O60447","Ecotropic viral integration site 5 protein homolog [OS=Homo sapiens]",4,3,3,3,810,92.9,6.1,9.69,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","EVI5","ENSG00000067208","","","",229.4,160.9,221.2,233.7,214.6,196.4,0.9485031797735383,-0.07627548473419041,0.6703480915979635,0.1736996226674212,0.8091015457098314,0.09199696914927409,6469]
["High","O60462-1","Neuropilin-2 [OS=Homo sapiens]",3,2,2,2,931,104.8,5.17,3.8,"","","","","","","","",14.7,12.1,16.5,23.5,21.7,17.6,0.6894904458598725,-0.5363975341649023,0.03974627349183212,1.40070358343016,0.19983187599756938,0.6993352345000831,1553]
["High","O60476","mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [OS=Homo sapiens]",11,5,7,5,641,73,7.61,10.76,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","MAN1A2","ENSG00000198162","","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum",166.5,136.8,166.9,155.9,164.9,170.7,0.9566632756866735,-0.06391687757492148,0.5488480036901846,0.2605479111022658,0.7285625999341995,0.1375331266146809,5882]
["High","O60481","Zinc finger protein ZIC 3 [OS=Homo sapiens]",5,3,5,2,467,50.5,8.65,8.13,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZIC3","ENSG00000156925","Mesodermal commitment pathway","POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","Signaling pathways regulating pluripotency of stem cells",362.6,357.4,326,359.3,358,364.6,0.9668176356410019,-0.04868430546222382,0.3608819229162752,0.44263487181784267,0.5958481823071001,0.22486438117463356,4729]
["High","O60488-1","Long-chain-fatty-acid--CoA ligase 4 [OS=Homo sapiens]",30,16,48,13,711,79.1,8.38,113.55,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL4","ENSG00000068366","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway",1768,1688.8,1932.4,1842.1,2124.2,2078.5,0.8915431445209108,-0.16562347888764029,0.12546275898803033,0.9014851663435397,0.35199900186077643,0.4534585680189473,2783]
["Medium","O60493-1","sorting nexin-3 [OS=Homo sapiens]",9,1,1,1,162,18.8,8.66,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","LOC111158258; Snx3; SNX3; Snx3_1","ENSAMEG00000008145; ENSANAG00000028701; ENSBIXG00000016466; ENSBIXG00005007963; ENSBMUG00000010256; ENSBTAG00000018801; ENSCANG00000036155; ENSCATG00000029122; ENSCCAG00000022069; ENSCGRG00015001325; ENSCHIG00000003391; ENSCJAG00000005955; ENSCSAG00000015156; ENSDLEG00000017815; ENSFCAG00000024997; ENSG00000112335; ENSLCNG00005012116; ENSMFAG00000039300; ENSMMNG00015010894; ENSMMUG00000020366; ENSMNEG00000027766; ENSMPUG00000009812; ENSMUSG00000019804; ENSNVIG00000004406; ENSOARG00000010805; ENSPANG00000017995; ENSPCOG00000020531; ENSPCTG00005013214; ENSPPAG00000032382; ENSPPYG00000016894; ENSPTRG00000018473; ENSPTRG00000046352; ENSRFEG00010011106; ENSRROG00000037899; ENSSBOG00000028606; ENSSSCG00000004385; ENSSSCG00070023370; ENSSSUG00005019212; ENSSTOG00000007274; ENSTSYG00000035289; ENSTTRG00000008868; ENSUAMG00000027552","","Ub-specific processing proteases; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking","Endocytosis",27.1,30.1,30.6,38.1,27.7,19.6,1.0281030444964872,0.03998486991486785,0.890690567628331,0.0502731468182971,0.9387840108048068,0.027434315833539603,7408]
["Medium","O60499","Syntaxin-10 [OS=Homo sapiens]",4,1,1,1,249,28.1,4.89,2.33,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","STX10","ENSG00000104915","","Retrograde transport at the Trans-Golgi-Network","Salmonella infection",60.7,56.8,54.7,51,50.8,63.1,1.0442692540933898,0.06249374395937668,0.6120878209319838,0.21318626182519745,0.7702146181848396,0.11338824300131065,6205]
["High","O60502","protein O-GlcNAcase [OS=Homo sapiens]",30,25,64,25,916,102.8,4.91,110.82,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","OGA","ENSG00000198408","","","Insulin resistance",2523.8,2190,2379,2684.2,2717.5,2570.9,0.8896470411158218,-0.1686950206408743,0.05096356025138642,1.2927402403367105,0.22803637733113188,0.6419958669732738,1745]
["High","O60504-1","Vinexin [OS=Homo sapiens]",10,5,5,5,671,75.3,9.45,8.12,"cell adhesion;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","SORBS3","ENSG00000120896","","Smooth Muscle Contraction","",110.9,115.2,150.2,144.8,147.3,165.1,0.8230533683289589,-0.2809421141465969,0.12617581903277003,0.8990238674917755,0.3532380046639901,0.4519325770991901,2789]
["High","O60506","Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",57,31,235,2,623,69.6,8.59,555.55,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","SYNCRIP","ENSG00000135316","","","",9014.5,9593.8,8828.3,9705.2,9694.4,9750,0.9412341850316985,-0.08737437560003129,0.06890094978434097,1.1617747913978131,0.2621728147739446,0.5814123431789564,2052]
["High","O60506-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",55,29,216,1,562,62.6,7.56,498.21,"","","","SYNCRIP","","","","",114.5,110.7,104.9,124.2,127.7,113.8,0.9026524473612252,-0.14775748811883205,0.07739071754867675,1.1113111266445246,0.2804021914710293,0.5522185964826396,2155]
["High","O60507","Protein-tyrosine sulfotransferase 1 [OS=Homo sapiens]",5,2,2,2,370,42.2,9.09,2.99,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","TPST1","ENSG00000169902","","Cytosolic sulfonation of small molecules; Gamma carboxylation, hypusine formation and arylsulfatase activation; Defective F8 sulfation at Y1699","",160.6,112.3,154.1,129.4,120.1,125.9,1.1374533830580715,0.1858074196769786,0.3258979908797099,0.486918316897682,0.5666024299240202,0.24672156730176137,4491]
["High","O60508","pre-mRNA-processing factor 17 [OS=Homo sapiens]",25,12,18,12,579,65.5,7.06,29.06,"RNA metabolism OR transcription;other metabolic processes","nucleus","","CDC40","ENSG00000168438","mRNA processing","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","Spliceosome",719.6,505.4,696.3,741.2,640,684.3,0.9301863955458726,-0.10440825502702146,0.5508987429100133,0.25892821863751064,0.7299198005500397,0.13672485507402443,5893]
["High","O60512","beta-1,4-galactosyltransferase 3 [OS=Homo sapiens]",5,2,4,2,393,43.9,9.25,8.84,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi","other molecular function","B4GALT3","ENSG00000158850","","N-Glycan antennae elongation; Keratan sulfate biosynthesis","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways",178.2,144.7,147.3,154.8,167.7,179.2,0.9372134741877616,-0.09355039911127545,0.4601269979440707,0.33712228376597514,0.6672867013275082,0.17568753032326015,5384]
["High","O60513","Beta-1,4-galactosyltransferase 4 [OS=Homo sapiens]",6,2,2,2,344,40,9.07,5.73,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B4GALT4","ENSG00000121578","","N-Glycan antennae elongation; Keratan sulfate biosynthesis","Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways",106.1,43.4,103.2,100.9,115.5,106.9,0.7816269718527683,-0.35544784318131045,0.3225100973640471,0.4914566836307635,0.5639773438339261,0.24873834219669333,4465]
["High","O60518","ran-binding protein 6 [OS=Homo sapiens]",4,4,30,1,1105,124.6,5.01,33.4,"transport","nucleus;other cell component","other molecular function","RANBP6","ENSG00000137040","","","",39.2,39.1,39.4,31.5,34,41,{"$f":"AVERAGE(T514:V514)/AVERAGE(W514:Y514)","v":1.1051643192488265},{"$f":"LOG(Z514,2)","v":0.1442608899252439},{"$f":"TTEST(T514:V514,W514:Y514,2,2)","v":0.2596008213695794},{"$f":"-LOG10(AB514)","v":0.585693937774166},{"$f":"AB514*7808/AF514","v":0.5062345687446743},{"$f":"-LOG10(AD514)","v":0.29564820192281166},4004]
["High","O60524","nuclear export mediator factor NEMF [OS=Homo sapiens]",16,16,29,16,1076,122.9,6.35,56.39,"protein metabolism;other metabolic processes;transport","nucleus;other cell component","translation activity;nucleic acid binding activity","NEMF","ENSG00000165525","","","",1165,1183.3,1253.6,1296.5,1315.3,1244.4,0.9340542502982211,-0.09842175013092055,0.06904137284795336,1.1608905815112296,0.2625791715522746,0.5807397262231861,2053]
["High","O60547-1","GDP-mannose 4,6 dehydratase [OS=Homo sapiens]",24,8,14,8,372,41.9,7.31,28.11,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","GMDS","ENSG00000112699; ENSPPAG00000026874; ENSPPYG00000016168; ENSPTRG00000017663","","GDP-fucose biosynthesis","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",939.8,711.8,1000.3,990.5,1117.4,1050.1,0.8397403419886003,-0.25198479703881477,0.15100641129375722,0.8210046134327164,0.3820667723206923,0.4178607305012104,3086]
["High","O60551","Glycylpeptide N-tetradecanoyltransferase 2 [OS=Homo sapiens]",13,6,24,2,498,56.9,7.58,43.67,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NMT2","ENSG00000152465","","Membrane binding and targetting of GAG proteins; Inactivation, recovery and regulation of the phototransduction cascade","",113.5,104.7,94.6,116.3,107.7,115.2,0.9221698113207546,-0.1168956572558471,0.22211365304576647,0.6534247450976488,0.4653242294020243,0.332244333192853,3727]
["High","O60563","Cyclin-T1 [OS=Homo sapiens]",17,10,15,10,726,80.6,8.78,34.59,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","CCNT1","ENSG00000129315","Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins","Transcriptional misregulation in cancer",1255.6,1489,1199.6,1003.2,929,1013.6,1.3389232127096204,0.42107322442651784,0.02283102807741304,1.641474531860853,0.15747762122653802,0.8027811540544703,1132]
["High","O60566","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta [OS=Homo sapiens]",29,25,53,25,1050,119.5,5.27,104.76,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","BUB1B","ENSG00000156970","Regulation of sister chromatid separation at the metaphase-anaphase transition","Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Human T-cell leukemia virus 1 infection",2673.2,2165.1,2504.3,2305.4,2115.5,2134.9,1.1200158638152478,0.16351916664493696,0.17889745543350646,0.7473958366212583,0.418588951760509,0.3782122386174156,3337]
["High","O60568","Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [OS=Homo sapiens]",29,18,53,18,738,84.7,6.05,89.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi","other molecular function","PLOD3","ENSG00000106397","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway","Collagen biosynthesis and modifying enzymes","Lysine degradation; Other types of O-glycan biosynthesis; Metabolic pathways",1678.8,1525.7,1725.3,1689,1710.3,1655.7,0.9752324431256182,-0.03618197389448535,0.5399592022702723,0.26763905295156243,0.7217944617918655,0.14158645453262111,5841]
["High","O60573","eukaryotic translation initiation factor 4E type 2 [OS=Homo sapiens]",42,10,20,10,245,28.3,8.88,48.7,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF4E2","ENSG00000135930","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance","ISG15 antiviral mechanism","EGFR tyrosine kinase inhibitor resistance; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Longevity regulating pathway; Insulin signaling pathway",959.2,901.3,1099.7,1109.4,1113.3,1111.1,0.8879356890035395,-0.17147290537903342,0.1020558233293281,0.9911622092954039,0.3181045383454666,0.49743013484003296,2505]
["High","O60583-2","Isoform 2 of Cyclin-T2 [OS=Homo sapiens]",16,9,15,9,663,73.6,9.14,33.54,"","","","CCNT2","","","","",727.9,862.2,741.3,651.4,596.3,623.7,1.2458052794699155,0.31707859139868777,0.028188513463803896,1.5499278262741834,0.17357721855313946,0.7605072751612619,1268]
["High","O60610-1","Protein diaphanous homolog 1 [OS=Homo sapiens]",38,45,105,44,1272,141.3,5.41,228.5,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH1","ENSG00000131504","Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway","RHOC GTPase cycle; RHOA GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility","Focal adhesion; Regulation of actin cytoskeleton; AGE-RAGE signaling pathway in diabetic complications; Shigellosis",5611.8,4801.8,5542.2,5340.7,5225.3,5411.3,0.9986543408460753,-1.9426831761416529E-3,0.9797038833973752,0.00890517047034447,0.9883111009776105,0.005106326494601682,7740]
["High","O60613-1","selenoprotein F [OS=Homo sapiens]",15,2,6,2,162,17.8,5.03,5.79,"","","","","","","","",61.7,47.5,76.8,59,62.4,58.4,1.0344827586206895,0.0489096004809462,0.8209010577249878,0.08570918474843806,0.9003505350072629,0.045588373026804074,7119]
["High","O60636","tetraspanin-2 [OS=Homo sapiens]",5,1,1,1,221,24.1,7.77,0,"cell organization and biogenesis;stress response;developmental processes","plasma membrane;other membranes;nucleus;other cell component","","TSPAN2","ENSG00000134198","","","",15.7,22,22.6,24.7,18,24.5,0.8973214285714286,-0.15630323087867543,0.501480258731196,0.2997461587409864,0.6964706261425077,0.1570971953537729,5622]
["High","O60637","Tetraspanin-3 [OS=Homo sapiens]",12,4,5,4,253,28,5.81,9.62,"","plasma membrane;other membranes","","TSPAN3","ENSG00000140391","","","",217.3,265.8,237.2,170.1,154.5,174.9,1.4420420420420421,0.528113226271792,0.008708300767272782,2.0600665797100457,0.10178804250129624,0.9923032375269559,668]
["High","O60645","exocyst complex component 3 [OS=Homo sapiens]",17,12,20,12,756,86.8,6.11,44.52,"","","","","","","","",833.1,697.3,852.7,820.4,829.9,838.2,0.9576451677717502,-0.06243689563063516,0.5140765622884979,0.2889721959789243,0.7056803442947593,0.15139197904199883,5688]
["High","O60664-1","Perilipin-3 [OS=Homo sapiens]",59,23,111,23,434,47,5.44,261.52,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","PLIN3","ENSG00000105355","","Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle; Lipophagy; Chaperone Mediated Autophagy","",4343.3,4233.4,4211.1,4218.7,3908.9,4018,1.0528751152680806,0.07433432404806305,0.09782984467901094,1.0095286359878428,0.3120324457735774,0.505800244802731,2448]
["High","O60671-1","Cell cycle checkpoint protein RAD1 [OS=Homo sapiens]",14,2,4,2,282,31.8,4.83,6.33,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD1","ENSCCAG00000029737; ENSG00000113456; ENSGGOG00000004219; ENSMFAG00000012657; ENSMMUG00000045918; ENSPANG00000024799; ENSPPAG00000028406; ENSPPYG00000015389; ENSPTRG00000016783","miRNA regulation of DNA damage response; ATR signaling; DNA damage response","Presynaptic phase of homologous DNA pairing and strand exchange; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","Cellular senescence",47.6,44,44.6,54,56.3,49.3,0.8533834586466166,-0.22873394821027454,0.029079022210852404,1.5364202008243697,0.17600698094754696,0.7544701064649832,1290]
["High","O60674","Tyrosine-protein kinase JAK2 [OS=Homo sapiens]",1,1,2,1,1132,130.6,7.21,2.52,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK2","ENSG00000096968","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Mesodermal commitment pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; IL-6 signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; Overview of interferons-mediated signaling pathway; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 distal deletion syndrome; CCL18 signaling pathway; EPO receptor signaling; Notch signaling pathway; Type II interferon signaling (IFNG); Serotonin receptor 2 and STAT3 signaling","Potential therapeutics for SARS; Signaling by BRAF and RAF1 fusions; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Signaling by SCF-KIT; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Interleukin-4 and Interleukin-13 signaling; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; RMTs methylate histone arginines; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; RAF activation; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; IL-6-type cytokine receptor ligand interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; PI3K-Akt signaling pathway; Necroptosis; Signaling pathways regulating pluripotency of stem cells; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Cholinergic synapse; Prolactin signaling pathway; Adipocytokine signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis B; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",20.2,25.2,22.6,27.6,30.6,25.2,0.815347721822542,-0.2945126373069618,0.07329000997360854,1.1349552192063024,0.2708227155106178,0.5673149115999804,2113]
["High","O60678","protein arginine N-methyltransferase 3 [OS=Homo sapiens]",18,8,22,8,531,59.8,5.35,43.19,"","","","","","","","",689.2,502.2,706.5,737.2,737.3,734.9,0.8590114963338462,-0.21925065549935943,0.18762119835421076,0.7267180944849302,0.42734723359092114,0.3692191030774553,3428]
["High","O60684","Importin subunit alpha-7 [OS=Homo sapiens]",44,20,107,12,536,60,4.98,265.21,"transport;other biological processes","nucleus;other cell component","other molecular function","KPNA6","ENSG00000025800","","Assembly of the ORC complex at the origin of replication","Nucleocytoplasmic transport; Influenza A; Chemical carcinogenesis",5079.4,4570.1,5063.4,4905,5048.5,4890.7,0.9911547944651784,-0.012817705722148015,0.8144120728676031,0.08915579696591415,0.896507749182327,0.047445952155809615,7093]
["High","O60701","UDP-glucose 6-dehydrogenase [OS=Homo sapiens]",53,21,75,21,494,55,7.12,177.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus","other molecular function","UGDH","ENSG00000109814","Glucuronidation","Formation of the active cofactor, UDP-glucuronate","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",3365.4,2524.5,3301.7,3076.6,3284.9,3283.3,0.9530109489051095,-0.06943530589341844,0.6169633931826842,0.20974060356870303,0.7729862281724003,0.11182824357457569,6232]
["High","O60716-1","Catenin delta-1 [OS=Homo sapiens]",46,35,142,35,968,108.1,6.23,291.16,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","CTNND1","ENSG00000198561","VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency","VEGFR2 mediated vascular permeability; Adherens junctions interactions; InlA-mediated entry of Listeria monocytogenes into host cells","Rap1 signaling pathway; Adherens junction; Leukocyte transendothelial migration",5855.8,5189.7,5782,6556.4,6110.7,6218.4,0.8910275078764132,-0.1664581234495998,0.05165644906987086,1.2868754510927085,0.22877683172861696,0.640587958733395,1763]
["High","O60725","protein-s-isoprenylcysteine O-methyltransferase [OS=Homo sapiens]",6,2,3,2,284,31.9,7.96,5.94,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ICMT","ENSG00000116237","Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome","RAS processing; Gamma carboxylation, hypusine formation and arylsulfatase activation","Terpenoid backbone biosynthesis",337.4,363.7,349.4,344.4,350.4,349.8,1.0056480949645799,0.008125553188151169,0.8142328893760236,0.08925135910960927,0.8964368866677935,0.04748028137985407,7092]
["Medium","O60729-1","Dual specificity protein phosphatase CDC14B [OS=Homo sapiens]",2,1,1,1,498,56.8,9.03,1.72,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CDC14B","ENSG00000081377; ENSPPYG00000019417; ENSPTRG00000021155","Cell cycle; Cell cycle","MAPK6/MAPK4 signaling","Cell cycle",62.1,52.5,67.5,82.5,87.8,66.2,0.7699788583509514,-0.37710926124991934,0.08179536603904349,1.0872712997599603,0.28562532112381556,0.5442032943157106,2236]
["High","O60749","Sorting nexin-2 [OS=Homo sapiens]",30,15,58,13,519,58.4,5.12,116.69,"cell organization and biogenesis;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX2","ENSG00000205302","","Golgi Associated Vesicle Biogenesis","Endocytosis",2825.7,2563,2882.1,2761.6,2871.4,2864.9,0.9732757504795302,-0.039079484651906755,0.5091464808523978,0.2931572536673209,0.7015026861647294,0.15397066165018158,5667]
["High","O60762","Dolichol-phosphate mannosyltransferase subunit 1 [OS=Homo sapiens]",30,6,23,6,260,29.6,9.57,40.23,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DPM1","ENSG00000000419","VEGFA-VEGFR2 signaling pathway","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","N-Glycan biosynthesis; Metabolic pathways",889.6,850.2,861.9,879.8,909.8,925.2,0.958339472520996,-0.06139130263225444,0.10054712514076568,0.9976303423059335,0.31554338950928396,0.5009409136660792,2488]
["High","O60763-1","General vesicular transport factor p115 [OS=Homo sapiens]",42,38,134,38,962,107.8,4.91,304.95,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","USO1","ENSG00000138768","","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization","",6023.8,4922.2,5760.8,6021.5,6021.1,5974.7,0.9272643514844067,-0.10894740306211811,0.25922898414479834,0.586316442035952,0.5061415124287535,0.2957280415108383,3999]
["High","O60784","Target of Myb protein 1 [OS=Homo sapiens]",25,10,19,10,492,53.8,4.7,26.27,"transport;signal transduction","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","TOM1","ENSG00000100284","","Neutrophil degranulation","",398.7,261.2,385.1,426.8,337.5,362.5,0.9274050408235712,-0.10872852651932317,0.6225187811474528,0.2058475415404005,0.7769543867006572,0.10960447693355672,6256]
["High","O60825-1","6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",41,17,41,1,505,58.4,8.38,68.77,"other metabolic processes;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PFKFB2","ENSG00000123836; ENSGGOG00000012227; ENSPPAG00000041619; ENSPTRG00000001925","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects","Regulation of glycolysis by fructose 2,6-bisphosphate metabolism","Fructose and mannose metabolism; Metabolic pathways; AMPK signaling pathway; Thyroid hormone signaling pathway",1218.8,1031.6,1245.1,1165.5,1261,1257.1,0.9489358236507763,-0.075617573532984,0.4451370645005875,0.3515062425229064,0.6563985268405264,0.18283240230777484,5295]
["High","O60825-2","Isoform 2 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",45,17,40,1,471,54.4,7.56,67.1,"","","","PFKFB2","","","","",71.9,52.7,66,48.7,51.2,44.8,1.3172080165860403,0.39748319737821747,0.0626133335063962,1.2033331739517548,0.24968585700609883,0.6026060567602384,1958]
["High","O60826","Coiled-coil domain-containing protein 22 [OS=Homo sapiens]",16,8,11,8,627,70.7,6.74,31.95,"transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","CCDC22","ENSG00000101997","","Neddylation","",549,417.6,549,599.8,537.1,562.6,0.8917917034421888,-0.16522131692032582,0.265836042928068,0.5753861363219387,0.511495274317978,0.2911583743606306,4058]
["High","O60828","Polyglutamine-binding protein 1 [OS=Homo sapiens]",42,9,24,9,265,30.5,6.33,63.4,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PQBP1","ENSG00000102103","","mRNA Splicing - Major Pathway","Spliceosome",1202.5,1257.8,1070.2,1277.1,982.8,902.9,1.1162577463007461,0.15867018700239524,0.3880065085589182,0.41116098933487594,0.6167660461783456,0.20987954280935175,4912]
["High","O60830-1","Mitochondrial import inner membrane translocase subunit Tim17-B [OS=Homo sapiens]",33,4,14,4,172,18.3,9.03,34.75,"cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity","TIMM17B","ENSG00000126768; ENSGGOG00000011427; ENSNLEG00000007902; ENSPPAG00000036547; ENSPPYG00000020323; ENSPTRG00000021872","","Mitochondrial protein import","",445.7,457.5,447.7,459.2,464.2,464.2,0.9735514557509369,-0.03867086222338142,0.03797028931710097,1.4205560937124078,0.1951757860354999,0.7095740629165588,1519]
["High","O60831","PRA1 family protein 2 [OS=Homo sapiens]",16,3,6,3,178,19.2,9.19,8.51,"transport","other membranes;other cytoplasmic organelle","","PRAF2","ENSG00000243279","","","",311.9,286.8,314.5,287.7,253.4,299.5,1.0863668807994291,0.11951140307272752,0.21422601065705732,0.6691277996151669,0.45639200305874583,0.34066197393367825,3665]
["High","O60832-1","H/ACA ribonucleoprotein complex subunit 4 [OS=Homo sapiens]",45,21,88,21,514,57.6,9.42,241.12,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DKC1","ENSG00000130826; ENSGGOG00000001045; ENSPTRG00000022449","","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","Ribosome biogenesis in eukaryotes",3805.1,3661.8,3788,4060.1,4297.8,4232.3,0.8939413194389286,-0.16174796250894913,6.1084150355113845E-3,2.2140714625277322,0.0823739284926993,1.0842102215965328,579]
["High","O60841","Eukaryotic translation initiation factor 5B [OS=Homo sapiens]",39,50,196,49,1220,138.7,5.49,410.84,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","EIF5B","ENSG00000158417","Translation factors; Ciliary landscape","GTP hydrolysis and joining of the 60S ribosomal subunit","",10196.8,8383.6,9595.6,9088.2,8914,9221.6,1.0349767482864258,0.04959835660510869,0.588672518373843,0.23012623834645046,0.7569754649971947,0.12091819657523904,6072]
["High","O60858","E3 ubiquitin-protein ligase TRIM13 [OS=Homo sapiens]",15,5,5,5,407,47,6.01,7.74,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","TRIM13","ENSG00000204977","","ER Quality Control Compartment (ERQC)","",75.3,43.8,71.5,65.2,58.5,61.8,1.0274932614555254,0.039128932401776034,0.8746751948908931,0.05815318955415055,0.9305714568344587,0.03125027259514384,7339]
["High","O60870","DNA/RNA-binding protein KIN17 [OS=Homo sapiens]",33,13,23,12,393,45.3,8.95,49.7,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","KIN","ENSG00000151657","","Protein methylation","",1021.5,949.1,976.5,1150.4,1039.2,1125.1,0.8891000693878782,-0.16958228946017234,0.03676211324954347,1.4345995313926652,0.1930319974797817,0.714370695255984,1487]
["High","O60879","Protein diaphanous homolog 2 [OS=Homo sapiens]",11,11,15,11,1101,125.5,6.58,30.96,"cell organization and biogenesis;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH2","ENSG00000147202","","RHOF GTPase cycle","Regulation of actin cytoskeleton",732.6,578.9,713.9,807.1,752.3,750,0.8770243353251926,-0.1893112203292336,0.14215593641968186,0.8472349994946253,0.3718437358676301,0.42963953030137786,2985]
["High","O60884","DnaJ homolog subfamily A member 2 [OS=Homo sapiens]",49,18,78,18,412,45.7,6.48,164.08,"stress response;other biological processes","other membranes;cytosol","other molecular function","DNAJA2","ENSG00000069345","","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","Protein processing in endoplasmic reticulum",3786.5,4092.9,3702.8,3983.3,3820.9,3987.9,0.9821999474224269,-0.02591134958220535,0.6207285504707133,0.20709827873780523,0.7758361648912004,0.11022998002519158,6247]
["High","O60885-1","Bromodomain-containing protein 4 [OS=Homo sapiens]",12,13,29,10,1362,152.1,9.19,40.31,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD4","ENSG00000141867; ENSPTRG00000010619","VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome","Potential therapeutics for SARS","",682.5,645,636.6,2378.7,2148.6,2261.3,0.2893232772589341,-1.789245696144259,1.8855404049131851E-5,4.7245641567386985,0.007748578674506394,2.110777953032892,19]
["High","O60888-1","Protein CutA [OS=Homo sapiens]",25,3,30,3,179,19.1,5.5,46.54,"other biological processes","other membranes","other molecular function","CUTA","ENSG00000112514; ENSG00000226492","","","",577.1,836,695.9,643.8,637.9,642.1,1.0962678033059572,0.13260027211826889,0.45580992853216706,0.3412162191736953,0.6642336547180218,0.17767912378724995,5358]
["High","O60890","Oligophrenin-1 [OS=Homo sapiens]",3,2,3,2,802,91.6,7.96,6.85,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","OPHN1","ENSG00000079482","","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle","",40.6,41.4,32.7,41.7,38.7,43.4,0.9264943457189013,-0.11014592319843985,0.38291054130129,0.41690267761688143,0.6136628707882742,0.212070152583065,4872]
["High","O60906","Sphingomyelin phosphodiesterase 2 [OS=Homo sapiens]",6,2,2,2,423,47.6,6.98,3.61,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SMPD2","ENSG00000135587","TNF-alpha signaling pathway; S1P receptor signal transduction","Glycosphingolipid metabolism; Ceramide signalling; TNFR1-mediated ceramide production","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",30.1,27.9,42.3,35.8,37.6,44.1,0.8536170212765957,-0.22833915084018155,0.3270941170703562,0.48532726677950416,0.5674185438980984,0.24609647505934767,4501]
["High","O60907","F-box-like/WD repeat-containing protein TBL1X [OS=Homo sapiens]",10,4,9,1,577,62.5,6.55,17.27,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1X","ENSG00000101849","Ectoderm differentiation; Ectoderm differentiation; Rett syndrome causing genes","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression","Wnt signaling pathway",77.1,90.2,87,84.2,81.2,87.1,1.0071287128712871,0.010248074163586847,0.8956560412079819,0.04785874043250792,0.9409691024962221,0.026424636759457873,7432]
["High","O60911","Cathepsin L2 [OS=Homo sapiens]",8,3,8,2,334,37.3,8.76,14.61,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","CTSV","ENSG00000136943","Endochondral ossification; Endochondral ossification with skeletal dysplasias","MHC class II antigen presentation; Assembly of collagen fibrils and other multimeric structures; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; Trafficking and processing of endosomal TLR; Endosomal/Vacuolar pathway; Activation of Matrix Metalloproteinases","Lysosome; Apoptosis",449.3,451.5,476.1,395.5,399.5,444.1,1.1112097490113795,0.1521311617291649,0.06117990911404452,1.2133911725180329,0.24661472914943708,0.6079809885785084,1937]
["High","O60921","checkpoint protein HUS1 [OS=Homo sapiens]",20,4,12,4,280,31.7,6.84,21.23,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","","HUS1","ENSG00000136273","ATR signaling","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","Cellular senescence",304,272.6,308.4,306.5,327.1,332.1,0.9164336750543646,-0.12589762234111235,0.1216018066632792,0.9150599726120986,0.34779007561424324,0.45868281499421926,2730]
["Medium","O60925","prefoldin subunit 1 [OS=Homo sapiens]",6,1,1,1,122,14.2,6.81,2.38,"other biological processes","other cell component","other molecular function","PFDN1","ENSG00000113068","Cellular proteostasis","Prefoldin mediated transfer of substrate  to CCT/TriC","",98.3,111.7,106.3,173.8,121.4,110.4,0.7798323471400394,-0.35876409648594704,0.20983044716852978,0.6781314938456067,0.451586585306472,0.345258967575029,3628]
["High","O60927","Protein phosphatase 1 regulatory subunit 11 [OS=Homo sapiens]",12,1,4,1,126,13.9,7.01,8.42,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R11","ENSG00000204619; ENSG00000206501; ENSG00000227720; ENSG00000233314; ENSG00000234058; ENSG00000236560; ENSG00000237403; ENSG00000237829","","","",118.7,106,111.1,117.9,90.8,106.3,1.0660317460317459,0.09225040166238875,0.4688758835124531,0.3289421044904417,0.6733461280973393,0.17176163283351709,5437]
["High","O60930","Ribonuclease H1 [OS=Homo sapiens]",12,4,7,4,286,32,9.16,13.39,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","RNASEH1","ENSG00000171865","","","DNA replication",361.9,403.1,370.4,321,318.2,345.7,1.1528073916133619,0.20515149098074045,0.03052811781732249,1.5152999708978314,0.1798970142774747,0.7449760445120228,1325]
["High","O60934","Nibrin [OS=Homo sapiens]",9,4,4,4,754,84.9,6.9,2.27,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NBN","ENSG00000104320","miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks","Homologous recombination; Cellular senescence",25.8,52.4,23.1,34.2,13.3,21.3,1.4723837209302328,0.5581537040990405,0.3865317708518773,0.4128148035863213,0.6158008706001751,0.2105597014403155,4901]
["High","O60942-1","mRNA-capping enzyme [OS=Homo sapiens]",19,9,15,9,597,68.5,8.13,31.54,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RNGTT","ENSG00000111880; ENSGGOG00000007863; ENSNLEG00000013064; ENSPPAG00000024828; ENSPTRG00000018413","mRNA processing; Ciliary landscape; mRNA Processing","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA surveillance pathway",661.4,750.3,642.6,574.6,544.2,567.9,1.217940356909942,0.28444348554548465,0.02369564390361814,1.6253314853191405,0.16004808615869415,0.7957495147450153,1156]
["High","O75027-1","ATP-binding cassette sub-family B member 7, mitochondrial [OS=Homo sapiens]",22,13,31,13,752,82.6,9.33,70,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","ABCB7","ENSG00000131269","","Mitochondrial ABC transporters; Cytosolic iron-sulfur cluster assembly","ABC transporters",1882.9,1733.5,1986.4,1967.6,2065.8,2069.5,0.9180553507348966,-0.1233469566911554,0.1075489195380487,0.9683939482799625,0.32674784581832067,0.4857872669526217,2570]
["High","O75037","Kinesin-like protein KIF21B [OS=Homo sapiens]",4,6,6,4,1637,182.5,7.08,15.92,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF21B","ENSG00000116852","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",186.2,151.8,167.3,174.4,188.3,189.4,0.9152327476906358,-0.12778942117398634,0.23107697676413538,0.6362433230729931,0.4761807956121322,0.3222281236893509,3789]
["High","O75044","SLIT-ROBO Rho GTPase-activating protein 2 [OS=Homo sapiens]",28,29,63,26,1071,120.8,6.7,132.98,"","","","","","","","",2408.7,1972.5,2378.1,2382.8,2315.5,2307,0.9648837308894694,-0.05157298771411209,0.5960839116156693,0.22469259967837016,0.7616140045647433,0.11826507873956131,6111]
["High","O75052","Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein [OS=Homo sapiens]",18,7,19,6,506,56.1,6.3,27.08,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","NOS1AP","ENSG00000198929","Sudden infant death syndrome (SIDS) susceptibility pathways","","Circadian entrainment",255.6,521.1,273,239.4,258.3,227.8,1.4468642315644384,0.532929551006899,0.27826575888304583,0.5555402311185089,0.5254411234241407,0.279475940348439,4135]
["High","O75054","Immunoglobulin superfamily member 3 [OS=Homo sapiens]",10,10,13,10,1194,135.1,6.07,25.92,"developmental processes","other membranes","","IGSF3","ENSG00000143061","","","",448.4,514.3,449.6,586.8,569.3,551.9,0.8268735362997657,-0.2742613972979387,0.014743540928048644,1.831398200274006,0.13037097119615382,0.884819099192939,883]
["High","O75063","Glycosaminoglycan xylosylkinase [OS=Homo sapiens]",20,7,19,7,409,46.4,6.87,40.25,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;nucleus","kinase activity;other molecular function","FAM20B","ENSG00000116199","","","",582.6,555.6,585.5,617.4,629.2,647.6,0.9099883855981418,-0.1360799629242636,0.011812287015239446,1.9276660090807878,0.117341395693371,0.9305487504615602,786]
["High","O75064","DENN domain-containing protein 4B [OS=Homo sapiens]",1,1,1,1,1496,163.7,7.21,2.83,"other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","DENND4B","ENSG00000198837","","RAB GEFs exchange GTP for GDP on RABs","",14,22.2,15.3,14.1,19.9,24.7,0.8773424190800682,-0.18878807103947146,0.5793086337595037,0.23708999891994983,0.7504964015918708,0.12465138572922599,6027]
["High","O75083","WD repeat-containing protein 1 [OS=Homo sapiens]",52,22,173,22,606,66.2,6.65,467.8,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","WDR1","ENSG00000071127","Hypertrophy model","Platelet degranulation","",5604.1,5320,5793.8,5554.3,6032.3,5837.5,0.9594699295802942,-0.05969050277123742,0.2948875646280854,0.5303435412063332,0.5388443961189073,0.2685366293648943,4273]
["Medium","O75093-1","Slit homolog 1 protein [OS=Homo sapiens]",1,1,2,1,1534,167.8,6.57,0,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","SLIT1","ENSG00000187122","Spinal cord injury","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO","Axon guidance",39.9,35.4,41.4,34.4,36.8,32.3,1.1275362318840583,0.1731737933206609,0.11884869787374248,0.9250055721128835,0.34331136995863165,0.4643118131529735,2703]
["High","O75096","Low-density lipoprotein receptor-related protein 4 [OS=Homo sapiens]",6,8,12,8,1905,211.9,5.27,18.09,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LRP4","ENSG00000134569","","ECM proteoglycans","",474.3,460.8,478.3,543.6,502.2,488.9,0.9209617514823746,-0.11878685398068121,0.07962721612991047,1.098938467503086,0.2822193842679714,0.5494131599952182,2203]
["High","O75113","NEDD4-binding protein 1 [OS=Homo sapiens]",27,15,22,15,896,100.3,5.36,44.29,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","N4BP1","ENSG00000102921","","","",508.4,386.6,492.5,523.6,506.1,496.5,0.909120691914559,-0.13745626023895136,0.30188498143861087,0.5201584922785885,0.545124406816067,0.26350437290122575,4324]
["High","O75116","Rho-associated protein kinase 2 [OS=Homo sapiens]",32,43,81,39,1388,160.8,6.02,164.08,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","ROCK2","ENSG00000134318","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; G13 signaling pathway","RHOA GTPase cycle; RHOB GTPase cycle; G alpha (12/13) signalling events; RHOC GTPase cycle; Potential therapeutics for SARS; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; Wnt signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis",3814,3749.8,3536,3749.1,3528.4,3583.2,1.0220151555608752,0.03141659029744988,0.4980025145388549,0.3027684643736315,0.6943577916998891,0.1584166867211965,5600]
["High","O75122","CLIP-associating protein 2 [OS=Homo sapiens]",28,29,69,23,1294,141,8.47,123.98,"","","","","","","","",1754.2,1679.6,1706.5,2058.8,1866.5,1928.3,0.878143364766981,-0.18747160301524332,0.017321255303665815,1.761420637047315,0.1411736549175602,0.8502463414672242,958]
["High","O75127","pentatricopeptide repeat-containing protein 1, mitochondrial [OS=Homo sapiens]",16,10,20,10,700,78.8,8.59,39.44,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity","PTCD1","ENSG00000106246","","","",787.9,754.3,773.2,786.2,737.6,751.2,{"$f":"AVERAGE(T578:V578)/AVERAGE(W578:Y578)","v":1.0177582417582416},{"$f":"LOG(Z578,2)","v":0.025394904401627023},{"$f":"TTEST(T578:V578,W578:Y578,2,2)","v":0.48307950339988165},{"$f":"-LOG10(AB578)","v":0.3159813888210125},{"$f":"AB578*7808/AF578","v":0.6849255061823635},{"$f":"-LOG10(AD578)","v":0.1643566606436597},5507]
["High","O75128","Protein cordon-bleu [OS=Homo sapiens]",5,5,6,5,1261,135.5,7.75,9.69,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity","COBL","ENSG00000106078","","","",309,261.4,276.5,310.5,306.5,298.5,0.9250682687056253,-0.1123682565138504,0.1894362498999464,0.7225369122116094,0.42922757957596674,0.36731238066498373,3446]
["High","O75129","Astrotactin-2 [OS=Homo sapiens]",3,3,4,3,1339,148.1,5.97,2.75,"cell adhesion;transport;developmental processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","ASTN2","ENSG00000148219","","","",231.6,263.4,262.7,206.7,186.6,182.5,1.3159083014935744,0.39605895898975024,0.009252639554533652,2.033734355861943,0.1054665834186843,0.9768851226957331,685]
["High","O75131","Copine-3 [OS=Homo sapiens]",18,7,16,7,537,60.1,5.85,30.52,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CPNE3","ENSG00000085719","","Neutrophil degranulation; Glycerophospholipid biosynthesis","",557,535.5,556.4,548.5,553.1,520.2,1.0167098285855223,0.02390798932930593,0.5092661186446564,0.293055216372673,0.7015437287186798,0.15394525328946043,5668]
["High","O75132","Zinc finger BED domain-containing protein 4 [OS=Homo sapiens]",1,1,1,1,1171,130.2,6.83,2.39,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED4","ENSG00000100426","","","",30.2,38.5,25.5,17.4,14.9,18.5,1.8543307086614174,0.8908985628406174,0.02147881559103998,1.6679896706660442,0.1544259596085084,0.811279691260237,1086]
["High","O75143-1","Autophagy-related protein 13 [OS=Homo sapiens]",22,7,15,7,517,56.5,5.12,28.19,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","ATG13","ENSG00000175224","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease","Macroautophagy","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",577.4,543.8,620.7,603.8,576.7,597.3,0.9798065024187197,-0.02943122888803897,0.6402910761797826,0.19362255095247602,0.7901679663050012,0.10228058075298949,6327]
["High","O75145-1","Liprin-alpha-3 [OS=Homo sapiens]",6,9,9,3,1194,133.4,5.68,19.15,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;other cell component","","PPFIA3","ENSG00000177380","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",351.9,307.4,388.4,382.2,373.2,331.5,0.9639341245744777,-0.05299353909302309,0.6666594589987889,0.17609595445664353,0.8062696802761065,0.09351967151202215,6456]
["High","O75146","Huntingtin-interacting protein 1-related protein [OS=Homo sapiens]",20,19,30,18,1068,119.3,6.67,74.35,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","cytoskeletal activity;other molecular function","HIP1R","ENSG00000130787","","Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",1167,1140.2,1163.4,1139.8,1135.1,1112.6,1.0245313653136532,0.03496415212836779,0.07999448861429011,1.0969399335937355,0.28211245126484963,0.5495777454778042,2214]
["High","O75147","Obscurin-like protein 1 [OS=Homo sapiens]",9,12,17,12,1896,206.8,5.63,32.06,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","OBSL1","ENSG00000124006","","Neddylation","",613,662,640.8,785.7,812.1,839.9,0.7859047462772285,-0.34757363024201826,1.1850334925474829E-3,2.926269375035309,0.03904110341692298,1.4084779163867773,237]
["High","O75150","E3 ubiquitin-protein ligase BRE1B [OS=Homo sapiens]",39,39,91,37,1001,113.6,6.23,233.37,"protein metabolism;other metabolic processes","nucleus","other molecular function","RNF40","","","","",3766,3062.2,3637.1,3661.4,3758,3668.7,0.9438316753997529,-0.08339850512980117,0.39596992493711985,0.4023377987458666,0.6244664055562577,0.20449092041871533,4951]
["High","O75152","Zinc finger CCCH domain-containing protein 11A [OS=Homo sapiens]",36,27,85,27,810,89.1,8.37,174.52,"other metabolic processes;transport","nucleus","nucleic acid binding activity;other molecular function","ZC3H11A","ENSG00000058673","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",4507.6,4187,4321.9,4840.2,4608.1,4605.4,0.9261973715107054,-0.1106084321168112,0.046291289894970965,1.3345007175437562,0.21578650238801989,0.6659757242579848,1675]
["High","O75153","Clustered mitochondria protein homolog [OS=Homo sapiens]",31,32,66,32,1309,146.6,6.13,126.38,"cell organization and biogenesis","other cell component","nucleic acid binding activity","CLUH","ENSG00000132361","Translation factors","","",2345.8,2257.8,2443.8,2184.4,2179.1,2222,1.0701389416141525,0.0977981212660471,0.049836334178379425,1.3024539106637596,0.2251863988800848,0.6474578441479986,1728]
["High","O75154","Rab11 family-interacting protein 3 [OS=Homo sapiens]",3,2,2,1,756,82.4,4.51,2.62,"cell cycle OR cell proliferation;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RAB11FIP3","ENSG00000090565; ENSG00000275338","","VxPx cargo-targeting to cilium","Endocytosis",37,18.5,38,29.9,32.4,27.8,1.037735849056604,0.05343925896146073,0.8696132260599239,0.06067386363063794,0.9280945966478794,0.03240775577638178,7316]
["High","O75157","TSC22 domain family protein 2 [OS=Homo sapiens]",8,6,17,5,780,79.2,5.02,28.74,"stress response;other biological processes","","","TSC22D2","ENSG00000196428","","","",854.7,735.7,787.5,765.1,632.9,689.1,1.1393320875856452,0.18818831884848908,0.13303616209641825,0.8760302923843694,0.3605506260495778,0.4430337460061469,2881]
["High","O75164-1","Lysine-specific demethylase 4A [OS=Homo sapiens]",16,13,28,13,1064,120.6,5.85,65.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","KDM4A","ENSG00000066135","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","",1131.4,1269.5,1083.1,1092.7,1154.5,1174.7,1.0181478126187207,0.02594702413636556,0.7516354868119582,0.12399272383123427,0.8575058271519242,0.06676292004166158,6844]
["High","O75165","DnaJ homolog subfamily C member 13 [OS=Homo sapiens]",14,25,39,25,2243,254.3,6.74,89.93,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","DNAJC13","ENSG00000138246","","Neutrophil degranulation","",1515.7,1281.6,1578.1,1419.7,1567.1,1480.7,0.9793844432008951,-0.030052814804713092,0.7738726481436271,0.11133050283017357,0.871039013508064,0.059962392671070355,6937]
["High","O75167","Phosphatase and actin regulator 2 [OS=Homo sapiens]",4,2,3,2,634,69.7,8.16,6.72,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","enzyme regulator activity;cytoskeletal activity","PHACTR2","ENSG00000112419","","Platelet degranulation","",157.4,154.9,163.6,149.5,139.1,146.6,1.093520220588235,0.12897989791015235,0.02826664807101217,1.5487256881702407,0.17364751230406217,0.7603314340656135,1271]
["High","O75170","Serine/threonine-protein phosphatase 6 regulatory subunit 2 [OS=Homo sapiens]",7,4,5,4,966,104.9,4.87,2.06,"other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP6R2","ENSG00000100239","","","",82.4,109.2,69.4,76,57.9,82.2,1.2077741786210086,0.2723507345977393,0.3391146289854943,0.46965347489122194,0.5796425181958712,0.2368397654703782,4568]
["High","O75175","CCR4-NOT transcription complex subunit 3 [OS=Homo sapiens]",16,9,19,9,753,81.8,6.2,32.73,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","","CNOT3","ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615","","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",776.2,782.3,788.7,909,850.1,873.3,0.8916578027655372,-0.16543795085570506,0.005578097750017091,2.2535138794709977,0.07962301139329697,1.098961401145793,547]
["High","O75177","Calcium-responsive transactivator [OS=Homo sapiens]",9,2,2,2,396,43,6.44,2.63,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SS18L1","ENSG00000184402","","","",92.3,99.6,78,96.3,79.9,100.5,0.9754246476328152,-0.03589766714310318,0.8121363052270993,0.09037107465037335,0.8948857283676533,0.04823241798889639,7086]
["High","O75179-1","Ankyrin repeat domain-containing protein 17 [OS=Homo sapiens]",18,36,76,24,2603,274.1,6.52,163.5,"stress response;developmental processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","ANKRD17","ENSG00000132466","","","",2521.1,2585.2,2512.3,2499.4,2503.4,2442,1.0233451536643026,0.033292819077278615,0.12892799948552924,0.889652756024713,0.3550863562550308,0.449666014595003,2835]
["High","O75182-2","Isoform 2 of Paired amphipathic helix protein Sin3b [OS=Homo sapiens]",13,10,15,9,1130,129.3,6.98,26.54,"","","","SIN3B","","","","",324.2,291.2,299.4,314.8,309,297.4,0.9930525401650022,-0.010058045381172949,0.8577250070797148,0.0666519278279003,0.9210723222773226,0.035706267813130195,7271]
["High","O75190","DnaJ homolog subfamily B member 6 [OS=Homo sapiens]",36,12,36,11,326,36.1,9.16,88.88,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNAJB6","ENSG00000105993","","Regulation of HSF1-mediated heat shock response","",1702.6,2262.8,1665.3,1579.2,1543.3,1514.1,1.2144027951516194,0.28024701647433303,0.1630843665326266,0.7875876689660342,0.3994236931890679,0.3985661770314735,3188]
["High","O75191","xylulose kinase [OS=Homo sapiens]",7,3,3,3,536,58.3,5.86,8.4,"other metabolic processes","cytosol","kinase activity;other molecular function","XYLB","ENSG00000093217","","Formation of xylulose-5-phosphate","Pentose and glucuronate interconversions; Metabolic pathways",126.5,143.4,151.1,140.8,159.3,172.7,0.890439932318105,-0.16740980222377383,0.21596138370577628,0.665623898584301,0.45858756703146614,0.3385777237945281,3677]
["High","O75208-1","Ubiquinone biosynthesis protein COQ9, mitochondrial [OS=Homo sapiens]",9,2,4,2,318,35.5,5.94,15.33,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ9","ENSG00000088682","","Ubiquinol biosynthesis","",93.3,121.6,90,112.3,106.3,101.8,0.9516229712858926,-0.07153799739896188,0.6478405949983304,0.18853184170499476,0.7947116049877397,0.09979044503603356,6365]
["High","O75223-1","gamma-glutamylcyclotransferase [OS=Homo sapiens]",59,10,47,10,188,21,5.14,103.14,"cell organization and biogenesis;signal transduction","cytosol","other molecular function","C7orf24; GGCT","ENSG00000006625; ENSGGOG00000024930; ENSPPAG00000031715; ENSPTRG00000019041","Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases","Glutathione synthesis and recycling","Glutathione metabolism; Metabolic pathways",1906.3,2140.2,1921.3,2039.2,2102.4,2148.6,0.9487456678642967,-0.07590670193761385,0.2600479657269126,0.5849465392244004,0.5067268570990101,0.29522607699846476,4007]
["High","O75251","NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [OS=Homo sapiens]",14,3,12,3,213,23.5,9.99,24.45,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cell component","transporter activity;other molecular function","NDUFS7","ENSG00000115286","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",394.9,373.7,413.2,423.7,442.5,449.1,0.8985022428343342,-0.15440598990347185,0.03154880999619436,1.501017017460514,0.18192991761468655,0.740095877151004,1354]
["High","O75290-1","Zinc finger protein 780A [OS=Homo sapiens]",3,1,1,1,641,74.5,8.65,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF780A","ENSG00000197782; ENSG00000280568","","","Herpes simplex virus 1 infection",232.3,187.9,206.7,260.7,255.7,282.2,0.7849987478086653,-0.34923774219732656,0.019767898035792698,1.7040395077216584,0.14927248342695298,0.8260202418209467,1034]
["High","O75306-1","NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [OS=Homo sapiens]",29,10,26,10,463,52.5,7.55,62.3,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS2","ENSG00000158864","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",984.1,857.2,936.7,962.7,1052.5,1022.3,0.9145679012345679,-0.12883780939911307,0.12982262193392893,0.8866496239836771,0.3561683176599147,0.4483447150733072,2846]
["High","O75312","Zinc finger protein ZPR1 [OS=Homo sapiens]",28,12,22,12,459,50.9,4.73,52.98,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ZPR1","ENSG00000109917","","","",1611,1506.7,1448.6,1512.1,1445.2,1462.7,1.033099547511312,0.04697927625656797,0.3977868524189947,0.4003495751991187,0.6253110013463883,0.20390393053570663,4967]
["High","O75323-1","Protein NipSnap homolog 2 [OS=Homo sapiens]",23,6,14,5,286,33.7,9.36,26.19,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;mitochondrion","","NIPSNAP2","ENSG00000146729","","RHOJ GTPase cycle; RHOH GTPase cycle","",435.5,476.9,462.5,449.4,451.3,436.4,1.028270136863361,0.04021932476165843,0.38752220714818464,0.411703404988457,0.6164982464166718,0.21006815438478824,4908]
["High","O75326-1","Semaphorin-7A [OS=Homo sapiens]",11,5,9,5,666,74.8,7.64,24.53,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding","SEMA7A","ENSG00000138623; ENSG00000288455","","Other semaphorin interactions","Axon guidance",287.8,425.7,299.3,191.6,190.9,203.9,1.7271487039563436,0.7883923012945293,0.03280936857394855,1.4840021276599331,0.18536581029333593,0.7319703660394773,1382]
["High","O75330-1","Hyaluronan mediated motility receptor [OS=Homo sapiens]",38,27,58,26,724,84,5.83,119.76,"","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","HMMR","ENSG00000072571","","AURKA Activation by TPX2; Hyaluronan uptake and degradation","ECM-receptor interaction",3006.1,2085.6,2698.6,2147.1,1961.1,2005,1.274340770791075,0.3497511195027439,0.11309395535081655,0.9465606066389913,0.33537318776269487,0.4744716610864242,2633]
["High","O75340","programmed cell death protein 6 [OS=Homo sapiens]",41,6,10,1,191,21.9,5.4,17.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PDCD6","ENSG00000249915","Epithelial to mesenchymal transition in colorectal cancer","","",161.4,246.6,192.8,190.9,198.9,180.9,1.052742246364114,0.07415224983782119,0.7131607774393021,0.14681255025564574,0.8355881377920275,0.07800773399574149,6664]
["High","O75340-2","Isoform 2 of Programmed cell death protein 6 [OS=Homo sapiens]",40,6,9,1,189,21.7,5.4,15.25,"","","","PDCD6","","","","",497.9,416.5,516.7,531,558,546.5,0.8750229287679608,-0.19260727361504804,0.09827193972395151,1.007570471615681,0.31254880055585066,0.505082163416033,2455]
["High","O75347","Tubulin-specific chaperone A [OS=Homo sapiens]",44,5,7,5,108,12.8,5.29,8.45,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TBCA","ENSG00000171530","VEGFA-VEGFR2 signaling pathway","Post-chaperonin tubulin folding pathway","",241.8,199.5,359,353.2,305.9,257.8,0.8728323699421967,-0.19622348831164546,0.5193705765261482,0.28452265773769225,0.7092069712340267,0.14922700410102693,5718]
["High","O75351","Vacuolar protein sorting-associated protein 4B [OS=Homo sapiens]",38,14,32,11,444,49.3,7.23,58.84,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS4B","ENSG00000119541","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)","Endocytosis; Necroptosis",1134.4,1001,1132.6,1263.6,1177.3,1179.1,0.9027624309392266,-0.14758171382488416,0.08933667026084283,1.0489702385027626,0.2987326429964286,0.5247173187462582,2335]
["High","O75352","Mannose-P-dolichol utilization defect 1 protein [OS=Homo sapiens]",10,2,10,2,247,26.6,8.94,17.33,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","","MPDU1","ENSG00000129255","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective MPDU1 causes CDG-1f","",276.6,233.5,287.6,256,335.2,293.3,0.901865460712267,-0.14901586499899658,0.36304055101702354,0.44004486229356204,0.5972651964477286,0.2238327915162468,4746]
["High","O75362","zinc finger protein 217 [OS=Homo sapiens]",13,11,16,10,1048,115.2,8.48,31,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","ZNF217","ENSG00000171940","","Estrogen-dependent gene expression","",737,790.4,746.3,951.2,909.5,899.3,0.8238043478260869,-0.27962635449014905,2.093885277029914E-3,2.6790471167917205,0.05141212655047034,1.2889344321175178,318]
["High","O75367-1","Core histone macro-H2A.1 [OS=Homo sapiens]",42,14,65,12,372,39.6,9.79,178.74,"cell organization and biogenesis;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","H2afy; H2AFY; LOC100466888; LOC101338325; LOC101381952; LOC101564704; LOC102987354; LOC103079324; LOC103663804; LOC106989149; LOC109250833; LOC110591142; LOC111141291; LOC111182462; LOC112404331; LOC112815157; LOC112861289; LOC112917035; LOC113261754; LOC113928700; LOC115516119; LOC116529369; MACROH2A1","ENSAMEG00000017887; ENSCAFG00000001076; ENSCANG00000022762; ENSCJAG00000005818; ENSFCAG00000013924; ENSG00000113648; ENSGGOG00000001707; ENSLCNG00005003680; ENSMLEG00000037795; ENSMNEG00000031666; ENSMPUG00000010011; ENSPCOG00000013464; ENSPCTG00005011747; ENSPPAG00000029258; ENSPTRG00000017256; ENSRBIG00000034425; ENSRROG00000045755; ENSSBOG00000034640; ENSSSUG00005001976; ENSVVUG00000017487","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma","","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus",4238.6,4306.1,4104.8,4091.9,4382.4,4364.6,0.9852479573795263,-0.021441241522966937,0.6001434568002588,0.22174492453330047,0.7639256783006881,0.11694889152113176,6134]
["High","O75368","SH3 domain-binding glutamic acid-rich-like protein [OS=Homo sapiens]",89,8,27,8,114,12.8,5.25,54.5,"","nucleus;other cell component","other molecular function","SH3BGRL","ENSG00000131171","","","",906.5,821.4,890.2,1126.6,918.7,945.1,0.8755016051364367,-0.1918182712025391,0.15252938966084048,0.8166464675448989,0.38368217605407295,0.41602837547241434,3104]
["High","O75369-1","Filamin-B [OS=Homo sapiens]",69,132,616,1,2602,278,5.73,1319.52,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLNB","ENSG00000136068","Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host","ISG15 antiviral mechanism","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer",22.4,26.4,14.1,18.2,9.1,15.3,1.4765258215962442,0.562206586653451,0.20776732584339994,0.6824227499532997,0.44974973112982164,0.3470290876130274,3607]
["High","O75369-8","Isoform 8 of Filamin-B [OS=Homo sapiens]",68,132,613,1,2633,281.5,5.71,1316.89,"","","","FLNB","","","","",21258.2,22873.7,20298.1,20466.8,19360.4,20101.6,1.0751091295003405,0.10448310874323977,0.14088333647195733,0.8511403717327028,0.37062570457312766,0.4310644636810569,2968]
["High","O75376-1","Nuclear receptor corepressor 1 [OS=Homo sapiens]",5,12,14,11,2440,270,7.11,29.93,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NCOR1","ENSG00000141027","Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome causing genes; 22q11.2 copy number variation syndrome; Notch signaling pathway","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis","Endocrine resistance; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer",855.7,945.5,772.1,903.2,812,783.3,1.0299379627776666,0.042557440817765954,0.707035423959547,0.15055882659241338,0.8320320407349123,0.07985994913423228,6635]
["High","O75379-1","Vesicle-associated membrane protein 4 [OS=Homo sapiens]",33,3,6,3,141,16.4,7.34,9.78,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP4","ENSCATG00000035773; ENSG00000117533; ENSGGOG00000023200; ENSMFAG00000031870; ENSMLEG00000033096; ENSMMUG00000023203; ENSMNEG00000025169; ENSNLEG00000015204; ENSPANG00000022546; ENSPPAG00000028975; ENSPTRG00000001680; ENSRBIG00000031656; ENSRROG00000036404","","Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network","SNARE interactions in vesicular transport",138.7,175,131.7,156.9,107.5,137.8,1.1074092491297862,0.14718847648243788,0.5047173463376132,0.296951768994768,0.6987292624475326,0.1556910683194749,5640]
["High","O75380","NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [OS=Homo sapiens]",39,3,4,3,124,13.7,8.28,14.64,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS6","ENSG00000145494","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",197,155.7,176.1,206,177.3,186.3,0.9283707865168538,-0.10722696945870631,0.40513213606704557,0.3924033061547458,0.6317698658700802,0.19944109289501954,5007]
["High","O75381-1","Peroxisomal membrane protein PEX14 [OS=Homo sapiens]",24,8,20,8,377,41.2,4.94,58.29,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PEX14","ENSG00000142655; ENSMFAG00000032533; ENSMMUG00000019979; ENSPANG00000017539; ENSPPAG00000038193; ENSPTRG00000000132","","Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Class I peroxisomal membrane protein import","Peroxisome",1199.5,1006,1191,1270.8,1236.6,1210,0.9136762253187714,-0.13024507936390312,0.17798626304645462,0.7496135151817801,0.4172070675072704,0.3796483432143215,3331]
["High","O75382-1","Tripartite motif-containing protein 3 [OS=Homo sapiens]",4,3,6,1,744,80.8,7.83,14.47,"protein metabolism;other metabolic processes;transport;developmental processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TRIM3","ENSG00000110171; ENSPTRG00000003290","","Interferon gamma signaling","",64.3,63,59.8,62.9,52.6,60.4,1.0636725412166004,0.0890540757688231,0.331041346441859,0.48011776027222536,0.5723584661244542,0.24233188886652024,4516]
["High","O75385","Serine/threonine-protein kinase ULK1 [OS=Homo sapiens]",3,2,2,2,1050,112.6,8.79,3.78,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","ULK1","ENSG00000177169","Target of rapamycin (TOR) signaling; Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; p53 transcriptional gene network; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease","RAB GEFs exchange GTP for GDP on RABs; Macroautophagy; TBC/RABGAPs; Receptor Mediated Mitophagy","Mitophagy; Autophagy; mTOR signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",25.3,20,21.2,15.5,22.2,19.5,1.1625874125874127,0.2173391936101627,0.2864228834028188,0.5429922875563494,0.5317141877340013,0.2743217512480163,4206]
["Medium","O75386","Tubby-related protein 3 [OS=Homo sapiens]",2,1,2,1,442,49.6,7.74,3.95,"developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TULP3","ENSG00000078246","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Genes related to primary cilium development (based on CRISPR)","Hedgehog 'off' state","",111.1,125.7,123.4,152.7,141.8,143.6,0.8221867153617897,-0.2824620334166744,0.0100620154441089,1.9973150204145516,0.11003391678935895,0.9584734275320905,714]
["High","O75390","citrate synthase, mitochondrial [OS=Homo sapiens]",39,16,87,16,466,51.7,8.32,160.5,"other metabolic processes","mitochondrion","other molecular function","CS","ENSG00000062485","TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)","Mitochondrial protein import; Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids",5185.3,4670.3,5019,4728.7,4911.8,5064.5,1.0115334920095205,0.016544088513215673,0.7693295667627661,0.11388757649872956,0.868931760058394,0.061014328722527496,6913]
["High","O75391","Sperm-associated antigen 7 [OS=Homo sapiens]",20,3,4,3,227,26,7.91,9.82,"","nucleus","nucleic acid binding activity","SPAG7","ENSG00000091640","","","",62.5,69.4,61.9,102.5,73.7,72.7,0.7786259541984735,-0.36099765956595437,0.142017788275955,0.8476572551503614,0.37173144178969375,0.4297707038537887,2983]
["High","O75396","Vesicle-trafficking protein SEC22b [OS=Homo sapiens]",38,8,52,8,215,24.6,6.92,131.89,"","","","","","","","",1232.2,1395.9,1345.1,1394.1,1381.6,1388.4,0.954155759948128,-0.06770329850757076,0.2598307398961193,0.5853094699777097,0.5064299593382176,0.2954806102766318,4006]
["High","O75400","pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",34,34,103,1,957,108.7,7.56,201.48,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","PRPF40A","ENSG00000196504","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",171,189.4,187.9,187.9,188.6,185.7,0.9752757025969405,-0.03611798008354403,0.48058125366289844,0.3182331740014196,0.683120048898582,0.1655029683641431,5493]
["High","O75400-3","Isoform 3 of Pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",34,34,102,1,939,106.8,7.43,195.17,"","","","PRPF40A","","","","",5525.5,7141,5229.1,5290.3,4792.3,5087.8,1.179639297579497,0.23834578912530188,0.21154932268468182,0.674588360806693,0.4532868033814478,0.3436269244490183,3644]
["High","O75410-1","Transforming acidic coiled-coil-containing protein 1 [OS=Homo sapiens]",27,16,31,13,805,87.7,4.88,72.42,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TACC1","ENSG00000147526","","","",1486.4,1402,1530.1,1393.3,1338.3,1362.2,1.0793150618007716,0.11011606199850218,0.05692852091088383,1.2446700996696762,0.23910591246486335,0.6214096847829393,1859]
["High","O75414","Nucleoside diphosphate kinase 6 [OS=Homo sapiens]",10,2,4,2,186,21.1,8.32,11.3,"other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","NME6","ENSG00000172113","Pyrimidine metabolism","","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",105.5,99.6,111.4,126.7,112.8,118.1,0.8850671140939597,-0.1761412368676142,0.060764025168892406,1.2163534650472736,0.24582668835166419,0.609370969396412,1930]
["High","O75420","GRB10-interacting GYF protein 1 [OS=Homo sapiens]",20,17,26,17,1035,114.5,5.39,41.2,"signal transduction","cytosol;other cell component","","GIGYF1","ENSG00000146830","","","",774.2,812,697.3,971.6,836.5,850.3,0.858975323502859,-0.21931140842631477,0.08395885175318892,1.0759335095925424,0.2880275546963528,0.5405659626569407,2276]
["High","O75427","Leucine-rich repeat and calponin homology domain-containing protein 4 [OS=Homo sapiens]",33,15,22,15,683,73.4,8.22,37.93,"developmental processes","nucleus","","LRCH4","ENSG00000077454","","","",370.3,420.2,362.6,308.8,274,280.8,1.3352246410375175,0.41708248441965096,0.010001865355777004,1.9999189961827382,0.10968337738470063,0.9598591851609591,712]
["High","O75431","Metaxin-2 [OS=Homo sapiens]",32,7,28,7,263,29.7,6.29,81.16,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus;other cell component","","MTX2","ENSG00000128654","","Mitochondrial protein import; Cristae formation","",897.8,1203.8,917.3,948.4,965.7,1009.4,1.0326321190354026,0.04632637756058052,0.767647149087758,0.11483835863720639,0.8684133497648818,0.06127350893403904,6902]
["High","O75436-1","Vacuolar protein sorting-associated protein 26A [OS=Homo sapiens]",30,9,24,8,327,38.1,6.57,44.85,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26A","ENSANAG00000022406; ENSCATG00000037809; ENSCCAG00000021117; ENSCJAG00000012907; ENSCSAG00000007798; ENSG00000122958; ENSMFAG00000042937; ENSMMUG00000004101; ENSMNEG00000039163; ENSNLEG00000011548; ENSPANG00000022152; ENSPPAG00000041182; ENSPPYG00000002386; ENSPTRG00000002567; ENSRBIG00000023684; ENSRROG00000006745; ENSSBOG00000030031","","WNT ligand biogenesis and trafficking","Endocytosis",548,506.7,585.1,550.3,723.1,606.6,0.8722340425531916,-0.1972127962079988,0.2239090979670379,0.6499282596295152,0.46783040859690445,0.3299115528205173,3737]
["Medium","O75438","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [OS=Homo sapiens]",19,1,1,1,58,7,8.92,2.39,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB1","ENSG00000183648","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",32,35.8,29.6,38.3,44.1,33.3,0.8418323249783923,-0.24839518702514787,0.16587910442064482,0.780208318052546,0.40235602588269487,0.39538949007952406,3219]
["High","O75439","mitochondrial-processing peptidase subunit beta [OS=Homo sapiens]",36,14,45,13,489,54.3,6.83,111.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;mitochondrion","other molecular function","PMPCB","ENSG00000105819","","Mitochondrial protein import; Processing of SMDT1","",1845.8,1784.6,1852.5,1894.6,1923.5,1983.9,0.9450017235436056,-0.08161113428852511,0.03536793542609363,1.451390291025639,0.19031897988072985,0.7205178988047396,1451]
["High","O75448","Mediator of RNA polymerase II transcription subunit 24 [OS=Homo sapiens]",20,15,19,15,989,110.2,6.95,36.25,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED24","ENSG00000008838","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",729.3,687.7,763.6,838.1,795.1,801.8,0.895523613963039,-0.15919661990872902,0.029907811865357174,1.5242153599397028,0.17839587092796702,0.7486152018318231,1309]
["High","O75449-1","Katanin p60 ATPase-containing subunit A1 [OS=Homo sapiens]",31,13,18,12,491,55.9,6.9,33.94,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNA1","ENSG00000186625","","","",452.6,540.2,476.9,458.5,430.5,420.5,{"$f":"AVERAGE(T642:V642)/AVERAGE(W642:Y642)","v":1.1223367697594502},{"$f":"LOG(Z642,2)","v":0.16650563776604874},{"$f":"TTEST(T642:V642,W642:Y642,2,2)","v":0.13404531587507382},{"$f":"-LOG10(AB642)","v":0.872748357549442},{"$f":"AB642*7808/AF642","v":0.36240506452651533},{"$f":"-LOG10(AD642)","v":0.44080574178840815},2888]
["High","O75461-1","transcription factor E2F6 [OS=Homo sapiens]",15,3,5,3,281,31.8,5.5,8.22,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F6","ENSG00000169016; ENSPPAG00000036538; ENSPTRG00000011661","G1 to S cell cycle control; Cell cycle","Transcriptional Regulation by E2F6; G1/S-Specific Transcription","",84,48.3,91.5,98,101.7,96.7,0.7550607287449393,-0.40533541132943973,0.14547532475547306,0.8372106646253404,0.37611633632143504,0.4246778029238556,3020]
["High","O75475-1","PC4 and SFRS1-interacting protein [OS=Homo sapiens]",65,40,255,39,530,60.1,9.13,511.39,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSIP1","ENSG00000164985; ENSGGOG00000016152; ENSPTRG00000020786","MECP2 and associated Rett syndrome","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection","",13932.9,21299.7,12901.4,15015.9,13547.4,14612.1,1.1148478068529764,0.15684677446401965,0.5708273110324831,0.24349525639313957,0.7430843021910016,0.1289619131580125,5998]
["High","O75477","erlin-1 [OS=Homo sapiens]",27,10,41,7,346,38.9,7.87,78.23,"","","","","","","","",449.9,414.7,445.9,478.6,504.7,460.3,0.907799944582987,-0.13955369468145287,0.059650629733946844,1.2243849671062201,0.24359420343235197,0.613333050387666,1912]
["High","O75478","Transcriptional adapter 2-alpha [OS=Homo sapiens]",5,2,3,2,443,51.5,6.89,4.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TADA2A","ENSG00000277104","","HATs acetylate histones","",48.6,31.3,52.4,50,63.1,47,0.8263585259212992,-0.2751602462375801,0.3195818355729025,0.49541791313351813,0.5620033721065817,0.25026107858950253,4440]
["High","O75487","Glypican-4 [OS=Homo sapiens]",8,3,5,2,556,62.4,6.68,10.26,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC4","ENSG00000076716","Wnt signaling","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Wnt signaling pathway",141.5,142.9,134.5,153,165.5,155.7,0.8833825390130746,-0.1788897786154846,0.016048637983158327,1.7945618194272284,0.1360562056161783,0.8662816449654419,921]
["High","O75489","NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [OS=Homo sapiens]",54,15,51,15,264,30.2,7.5,109.18,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS3","ENSG00000213619; ENSG00000285387","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","RHOG GTPase cycle; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",2144.7,2651.6,2131.4,2482.4,2378.3,2422.7,0.9511629184172226,-0.07223562292656494,0.5327076467180177,0.27351106911792117,0.7173820809890104,0.14424947547826444,5798]
["High","O75494-1","Serine/arginine-rich splicing factor 10 [OS=Homo sapiens]",31,12,42,9,262,31.3,11.27,92.81,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Srsf10; SRSF10","ENSCATG00000031598; ENSCCAG00000022497; ENSCPOG00000034102; ENSG00000188529; ENSGGOG00000000392; ENSMLEG00000016013; ENSMNEG00000041500; ENSMUSG00000028676; ENSNLEG00000027520; ENSPANG00000021680; ENSPCOG00000022379; ENSPCTG00005007467; ENSPPAG00000032557; ENSPPYG00000001726; ENSPTRG00000044753; ENSRBIG00000028456; ENSRFEG00010001865; ENSRROG00000043248; ENSSBOG00000019550; ENSSSCG00070027414; ENSSTOG00000000956; ENSTSYG00000009439","mRNA processing; mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","Spliceosome",2679.2,2678.8,2544.4,2894.9,2512.4,2743.1,0.9695720455437771,-0.04457999089575037,0.5284730140724493,0.27697718458862675,0.7153809455405139,0.14546263164136394,5768]
["High","O75496","Geminin [OS=Homo sapiens]",13,2,2,2,209,23.6,4.96,2.77,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","GMNN","ENSG00000112312","DNA replication","CDT1 association with the CDC6:ORC:origin complex; Activation of the pre-replicative complex","",179.5,143.2,191.4,261.4,167.4,150.5,0.8874503711375799,-0.17226165292147963,0.5925181610543712,0.22729833371478142,0.7592945677847579,0.11958970718061522,6093]
["High","O75503","Ceroid-lipofuscinosis neuronal protein 5 [OS=Homo sapiens]",10,2,2,2,358,41.5,7.4,5.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLN5","ENSG00000102805","","","Lysosome",16,14.4,12.9,16.7,20.6,21.1,0.7414383561643836,-0.4316013441532923,0.03828144780352524,1.417011645576708,0.19561619401173108,0.7085951951577436,1528]
["High","O75506","Heat shock factor-binding protein 1 [OS=Homo sapiens]",42,3,4,3,76,8.5,4.36,11.36,"stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","HSBP1","ENSG00000230989","","HSF1 activation; Attenuation phase","",233.7,176.6,262.1,290,241.7,230.8,0.8818360655737705,-0.181417612988806,0.38793856557068307,0.41123704437004205,0.6167836122940121,0.20986717384301048,4911]
["High","O75509","Tumor necrosis factor receptor superfamily member 21 [OS=Homo sapiens]",4,2,2,2,655,71.8,7.83,4.16,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","","TNFRSF21","ENSG00000146072","Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer","PPARA activates gene expression","Cytokine-cytokine receptor interaction",44.8,47.2,45.8,39.3,31.1,45.6,1.1879310344827587,0.24845108268935698,0.16286561863227655,0.7881705867426022,0.39926365785896867,0.3987402187553361,3185]
["High","O75521","Enoyl-CoA delta isomerase 2, mitochondrial [OS=Homo sapiens]",28,6,15,6,394,43.6,9,42.82,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ECI2","ENSG00000198721","","","Fatty acid degradation; Peroxisome",365.3,376.1,329.5,396.2,378.3,403.7,0.9089288745544051,-0.1377606897334836,0.08868185459057787,1.052165233125974,0.29705187500782154,0.5271677019879155,2331]
["High","O75525-1","KH domain-containing, RNA-binding, signal transduction-associated protein 3 [OS=Homo sapiens]",10,4,18,2,346,38.8,7.61,29.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHDRBS3","ENSCCAG00000031191; ENSG00000131773; ENSGGOG00000000940; ENSRBIG00000036854; ENSRROG00000044792","","PTK6 Regulates Proteins Involved in RNA Processing","",74.3,99.6,99.9,95.1,93.8,80.3,1.017087667161961,0.024444036647582084,0.882224955002268,0.054420661739545496,0.934275389754199,0.02952509098400856,7373]
["High","O75529-1","TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L [OS=Homo sapiens]",12,4,4,4,589,66.1,5.88,7.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","TAF5L","ENSG00000135801; ENSGGOG00000028544; ENSPPAG00000034307; ENSPTRG00000002091","","HATs acetylate histones","Basal transcription factors",161.4,112.5,134.2,112.8,121.6,117.1,1.1610241820768137,0.21539802129820296,0.2595294955950738,0.5858132773290634,0.5062219089698567,0.2956590627755331,4003]
["High","O75530","Polycomb protein EED [OS=Homo sapiens]",20,7,11,7,441,50.2,7.03,18.24,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","EED","ENSG00000074266","Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma","Transcriptional Regulation by E2F6; HCMV Early Events; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis","",452.3,456.2,488.3,551.3,597.6,603.7,0.7969873331051008,-0.32737129992089514,0.00412355371117846,2.384728344179181,0.06806914878833281,1.1670496802583574,473]
["High","O75531","Barrier-to-autointegration factor [OS=Homo sapiens]",25,3,5,3,89,10.1,6.09,2.34,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BANF1","ENSG00000175334","Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation","",125.8,123.9,149,172,118.7,131.5,0.944339175746092,-0.08262297334982506,0.6855010667266963,0.1639918650565875,0.8181584116481266,0.08716260018691495,6542]
["High","O75533-1","splicing factor 3B subunit 1 [OS=Homo sapiens]",49,55,274,55,1304,145.7,7.09,581.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101357717; LOC111145177; Sf3b1; SF3B1","ENSANAG00000021577; ENSCANG00000029415; ENSCATG00000035735; ENSCCAG00000020506; ENSCGRG00001016990; ENSCGRG00015028775; ENSCJAG00000003902; ENSCSAG00000011505; ENSDLEG00000016863; ENSFCAG00000005038; ENSG00000115524; ENSLAFG00000001956; ENSLCNG00005009987; ENSMMNG00015005194; ENSMMUG00000022430; ENSMNEG00000042333; ENSMPUG00000007799; ENSMUSG00000025982; ENSNLEG00000006861; ENSPANG00000013417; ENSPCTG00005000567; ENSPPAG00000035007; ENSRNOG00000013516; ENSRROG00000031308; ENSSBOG00000020080; ENSSSCG00000016075; ENSSSCG00070023758; ENSSSUG00005005995; ENSSTOG00000011034; ENSUMAG00000020945","mRNA processing; mRNA processing; mRNA processing","B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway","Spliceosome",13644.7,13044.2,13047.6,14551.2,14815.7,14641.3,0.9029339986638854,-0.14730755931892323,2.6573252454775206E-3,2.5755552865112685,0.05638150955621869,1.2488633005261507,368]
["High","O75534","cold shock domain-containing protein E1 [OS=Homo sapiens]",47,39,211,39,798,88.8,6.25,409.73,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity","CSDE1","ENSG00000009307","","","",9487.6,10871,9686.3,9453,10213.1,10086.7,1.0098175633889919,0.014094674989124477,0.8526897992335081,0.0692089324700802,0.9184441926355679,0.03694722756367967,7249]
["Low","O75541","zinc finger protein 821 [OS=Homo sapiens]",2,1,1,1,412,46.8,6.55,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF821","ENSG00000102984","","","",9.4,16.7,12,12.4,20,8.6,0.929268292682927,-0.10583291201212375,0.8197885099350459,0.08629817300021508,0.8998887509592068,0.0458111770394303,7113]
["High","O75553-5","Isoform DAB553 of Disabled homolog 1 [OS=Homo sapiens]",17,6,6,6,553,59.6,5.36,7.81,"","","","DAB1","","","","",193.1,179.6,183,177.7,186.1,200.5,0.9847598794967217,-0.022156109293862372,0.731671549477255,0.13568383186732796,0.8466051360874937,0.07231910112578015,6748]
["High","O75554","WW domain-binding protein 4 [OS=Homo sapiens]",18,5,7,5,376,42.5,5.57,13.15,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","WBP4","ENSG00000120688","","mRNA Splicing - Major Pathway","",363.1,414,339.2,364.8,311.3,339,1.099694611368338,0.13710293844596005,0.2785474289250212,0.5551008458522825,0.5254646835096801,0.27945646759440695,4139]
["High","O75569-1","Interferon-inducible double-stranded RNA-dependent protein kinase activator A [OS=Homo sapiens]",30,9,38,9,313,34.4,8.41,73.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function","PRKRA","ENSCATG00000032736; ENSG00000180228; ENSMNEG00000031681; ENSPANG00000001046; ENSPTRG00000012688","VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","",2122.8,1817,1987,1776.4,1676.3,1689.2,1.1526478539061438,0.20495182173116114,0.04947035381956771,1.3056549834838815,0.22457239687394456,0.648643625732795,1720]
["High","O75581","Low-density lipoprotein receptor-related protein 6 [OS=Homo sapiens]",11,13,17,13,1613,180.3,5.31,37.04,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","LRP6","ENSG00000070018; ENSG00000281324","MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Type I collagen synthesis in the context of osteogenesis imperfecta; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by WNT ligand antagonists; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","mTOR signaling pathway; Wnt signaling pathway; Parathyroid hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Pathways in cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer",622.8,582.5,637.3,713.9,704,699.9,0.870053829445651,-0.20082343292383067,0.005601376610007775,2.2517052264475605,0.07980939520244655,1.0979459802732945,548]
["High","O75586","Mediator of RNA polymerase II transcription subunit 6 [OS=Homo sapiens]",9,2,3,2,246,28.4,8.62,2.57,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MED6","ENSG00000133997","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway","",93.1,106.6,106.2,102.4,113,114.9,0.926127762640024,-0.11071686272732292,0.24001150313776223,0.6197679431653271,0.4873887689205845,0.31212448264414155,3845]
["High","O75592-1","E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",3,13,16,13,4640,509.8,7.03,32.47,"","","","","","","","",796.8,742.7,798.6,789.2,807.9,761.9,0.9911403136922424,-0.01283878365269163,0.7741216365015262,0.11119079395411521,0.8711936779769266,0.05988528480152083,6938]
["High","O75600-1","2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [OS=Homo sapiens]",3,1,1,1,419,45.3,8.05,2.88,"other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","GCAT","ENSG00000100116","","Threonine catabolism","Glycine, serine and threonine metabolism; Metabolic pathways",13.8,7.8,13.9,9.4,14.7,14.2,0.926892950391645,-0.10952536753291256,0.7406950246877342,0.13036057253204206,0.8519956913320313,0.06956260151904481,6788]
["High","O75607","Nucleoplasmin-3 [OS=Homo sapiens]",44,5,36,5,178,19.3,4.63,63.14,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NPM3","ENSG00000107833","","","",731.7,722.7,719.8,709.7,694.5,676.2,1.0450874831763122,0.06362371384870487,0.03885624470298291,1.4105391744922844,0.19764792093869094,0.7041077496468542,1535]
["High","O75608","Acyl-protein thioesterase 1 [OS=Homo sapiens]",56,8,40,8,230,24.7,6.77,72.67,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LYPLA1","ENSG00000120992","","RAS processing; eNOS activation","Glycerophospholipid metabolism; Choline metabolism in cancer",1404.3,1413,1448.6,1503.3,1509.9,1596.5,0.9254181400091112,-0.11182271605689177,0.025382273311603382,1.59546948379878,0.16570634616805954,0.7806608587925365,1196]
["High","O75616-1","GTPase Era, mitochondrial [OS=Homo sapiens]",7,2,4,2,437,48.3,8.84,9.83,"cell organization and biogenesis","other membranes;cytosol;mitochondrion","translation activity;nucleic acid binding activity;other molecular function","ERAL1","ENSG00000132591","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",85.7,77.9,88.1,91.6,105.1,91.5,0.873351839000694,-0.19536511901376805,0.09003657377114045,1.0455810398887424,0.29953368896679367,0.5235543248286996,2347]
["High","O75643-1","U5 small nuclear ribonucleoprotein 200 kDa helicase [OS=Homo sapiens]",49,87,348,87,2136,244.4,6.06,756.77,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","SNRNP200","ENSCATG00000015790; ENSG00000144028; ENSGGOG00000005174; ENSMLEG00000019083; ENSPPAG00000041559; ENSPPYG00000012068; ENSPTRG00000012230; ENSRBIG00000044690; ENSRROG00000037952","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",14614.5,11934,14757.3,13589.5,14386.9,13993,0.9841884801784156,-0.022993464912641197,0.8267140497473342,0.08264468161029465,0.9039326845577911,0.04386391002642796,7141]
["High","O75648-1","Mitochondrial tRNA-specific 2-thiouridylase 1 [OS=Homo sapiens]",14,4,4,4,421,47.7,8.03,6.21,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TRMU","ENSG00000100416","","tRNA modification in the mitochondrion","",104.2,99,127.5,106.5,122.2,118.7,0.9519286125503742,-0.07107470851927801,0.6064393500238624,0.21721262640012695,0.7683073900675511,0.11446498947216695,6163]
["High","O75663","TIP41-like protein [OS=Homo sapiens]",31,8,25,8,272,31.4,5.91,37.38,"stress response;signal transduction;other biological processes","cytosol","","TIPRL","ENSG00000143155","Ciliary landscape","","",1327.7,1285.5,1247.2,1283.5,1322.7,1282.1,0.9928246277293419,-0.010389191886549567,0.7459429884955905,0.12729436385162848,0.8540062836031629,0.06853893384947198,6820]
["High","O75665","Oral-facial-digital syndrome 1 protein [OS=Homo sapiens]",9,7,7,7,1012,116.6,6.1,18.72,"cell organization and biogenesis;transport;developmental processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","OFD1","ENSG00000046651","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state","",178,158.5,160.5,184.3,192.5,178.4,0.895172910662824,-0.15976171612861273,0.05916459654459789,1.227938092680429,0.24300745387702277,0.6143804048872369,1901]
["High","O75674","TOM1-like protein 1 [OS=Homo sapiens]",11,4,5,4,476,53,5.24,16.3,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TOM1L1","ENSG00000141198","","","",139.5,141.8,160.3,169,187.8,190.9,0.8062808106627716,-0.31064570825036825,0.020390612310671387,1.6905697325762963,0.1519178443909563,0.8183912105653687,1048]
["High","O75676","Ribosomal protein S6 kinase alpha-4 [OS=Homo sapiens]",3,2,3,2,772,85.6,8.28,4.53,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","RPS6KA4","ENSG00000162302","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Interferon type I signaling pathways","Recycling pathway of L1","MAPK signaling pathway; TNF signaling pathway",51.9,71.7,67.7,86.2,75,77.4,0.8017602682313496,-0.3187571693491156,0.0854749416819136,1.0681611868429415,0.290927787555528,0.536214795749555,2294]
["High","O75683","Surfeit locus protein 6 [OS=Homo sapiens]",25,6,19,6,361,41.4,10.64,38.08,"other biological processes","nucleus;other cell component","nucleic acid binding activity","SURF6","ENSG00000148296; ENSG00000281309","","","",456.5,421,443.2,592,497.7,480.8,0.8409423750397963,-0.2499211506407634,0.08241334953121766,1.0840024344417074,0.2868851685866016,0.5422919033660397,2243]
["High","O75688","Protein phosphatase 1B [OS=Homo sapiens]",29,13,39,1,479,52.6,5.05,86.64,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus","other molecular function","PPM1B","ENSG00000138032","MAPK signaling pathway","ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","MAPK signaling pathway",1212.8,1244.9,1212,1252.6,1239.8,1228.1,0.9863459212471444,-0.019834392153215696,0.260821357235299,0.5836568494827721,0.5067163864874881,0.2952350510161715,4019]
["High","O75688-2","Isoform Beta-2 of Protein phosphatase 1B [OS=Homo sapiens]",35,13,38,1,387,42.7,5.2,82.57,"","","","PPM1B","","","","",67.6,61.6,56,68.1,59.7,59.2,0.990374331550802,-0.013954171514762814,0.8986197427042006,0.046424044174660055,0.9430676009454837,0.025457175061903353,7440]
["High","O75691","Small subunit processome component 20 homolog [OS=Homo sapiens]",20,40,75,40,2785,318.2,7.39,149.83,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","","UTP20","ENSG00000120800","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2605.1,2094.6,2606.2,2736.6,2798.4,2789,0.8776910139356078,-0.18821495822404663,0.11885573303606999,0.9249798651273862,0.3432047202461666,0.4644467477383491,2704]
["High","O75694","nuclear pore complex protein nup155 [OS=Homo sapiens]",24,26,67,26,1391,155.1,6.16,169.68,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUP155","ENSG00000113569","","ISG15 antiviral mechanism; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis",3072.4,2702.3,3229.6,3211,3698.9,3316.9,0.8804611413149765,-0.18366876200552598,0.1314326489979861,0.8812967388980659,0.3589458283932408,0.44497108959741943,2859]
["High","O75695","Protein XRP2 [OS=Homo sapiens]",23,7,16,7,350,39.6,5.12,27.49,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","RP2","ENSG00000102218","Joubert syndrome; Ciliopathies","Trafficking of myristoylated proteins to the cilium","",835.6,1172.4,878.1,716.4,646.2,688.2,1.407304466549639,0.49293448554837327,0.061207755704182555,1.2131935444210606,0.246599667976397,0.6080075124771717,1938]
["High","O75717","WD repeat and HMG-box DNA-binding protein 1 [OS=Homo sapiens]",35,31,103,31,1129,125.9,5.62,237.63,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","WDHD1","ENSG00000198554","Mesodermal commitment pathway","","",3653.6,3789.9,3700.5,4326.9,4461.1,4327.5,0.849681674354771,-0.23500564521982142,3.9269765703975237E-4,3.405941689862106,0.02643261470833092,1.5778598744303893,116]
["High","O75718","Cartilage-associated protein [OS=Homo sapiens]",38,14,64,14,401,46.5,5.73,125.6,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cell component","","CRTAP","ENSG00000170275","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",3475,3292.4,3414.8,3270.6,3263.6,3253.1,1.0403482063490443,0.05706648172593532,0.07125657357483473,1.1471750648550427,0.2674862146501488,0.5726985951591689,2080]
["High","O75746","Calcium-binding mitochondrial carrier protein Aralar1 [OS=Homo sapiens]",10,6,15,2,678,74.7,8.38,27.89,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A12","ENSG00000115840","","Mitochondrial protein import; Gluconeogenesis; Aspartate and asparagine metabolism","",215.9,211.3,233.9,243.7,246.4,247.4,0.8964067796610169,-0.15777453467544572,0.021837295357956962,1.6608011518579646,0.154583501500388,0.8108368596395198,1103]
["High","O75781","Paralemmin-1 [OS=Homo sapiens]",17,5,6,5,387,42.1,5,11.9,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","signal transduction activity or receptor binding","PALM","ENSG00000099864","","","",254.8,285.8,284.7,306.3,261.3,253.1,1.005604971365907,0.008063687077912069,0.9408170537265806,0.026494818954773545,0.9678392036228118,0.01419679019161849,7590]
["High","O75787","Renin receptor [OS=Homo sapiens]",25,8,15,8,350,39,6.1,37.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ATP6AP2","ENSG00000182220","ACE inhibitor pathway; Oxidative phosphorylation","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","Renin-angiotensin system",805.6,826.1,768.6,775.4,729.3,729.5,1.0743442843075823,0.1034563933874913,0.07180962129908613,1.1438173635966131,0.26750454346529795,0.5726688372496669,2096]
["High","O75792","Ribonuclease H2 subunit A [OS=Homo sapiens]",21,7,11,7,299,33.4,5.25,31.7,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RNASEH2A","ENSG00000104889","","","DNA replication",361.9,331.9,362.6,416.9,400.5,405.1,0.8641308793456034,-0.2106782585598653,0.007885569390987932,2.1031669422290378,0.09696145796036815,1.0134008628623778,635]
["High","O75794","Cell division cycle protein 123 homolog [OS=Homo sapiens]",35,9,16,9,336,39.1,4.81,39.97,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","other cell component","","CDC123","ENSG00000151465","","","",659.3,663.9,639.6,797.3,793.1,767.1,0.8325768822905618,-0.26434459438159436,3.9714338220383962E-4,3.401052669917563,0.026278775663115084,1.5803948725650532,118]
["High","O75808-1","Calpain-15 [OS=Homo sapiens]",9,5,5,5,1086,117.2,6.71,12.48,"protein metabolism","other cell component","other molecular function","CAPN15","ENSG00000103326","","Degradation of the extracellular matrix","",231.2,273.7,216.9,177.9,177,183.1,1.3416356877323419,0.423992970453246,0.023380766944249926,1.6311412470581517,0.1595778219411743,0.7970274668565217,1144]
["High","O75815-1","Breast cancer anti-estrogen resistance protein 3 [OS=Homo sapiens]",6,4,4,4,825,92.5,7.96,3.91,"developmental processes;signal transduction;other biological processes","other membranes;other cell component","enzyme regulator activity;other molecular function","BCAR3","ENSG00000137936","","","",137.3,131.1,138.5,155.1,133.1,131.3,0.969964243146603,-0.04399653025347523,0.6268029450579544,0.20286897164918183,0.7803057071129638,0.10773521666692838,6272]
["High","O75817","Ribonuclease P protein subunit p20 [OS=Homo sapiens]",11,1,4,1,140,15.6,8.94,11.68,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP7","ENSG00000172336","","tRNA processing in the nucleus","Ribosome biogenesis in eukaryotes",77.9,144,90.1,96.7,90.7,88.7,1.1300253531329227,0.1763551411615413,0.5898461645698712,0.2292612402051068,0.7577359086807427,0.12048213129039545,6078]
["High","O75818-1","Ribonuclease P protein subunit p40 [OS=Homo sapiens]",8,2,8,2,363,41.8,6.67,17.47,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP40","ENSG00000124787","","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","Ribosome biogenesis in eukaryotes",165.1,164.5,167.2,175.2,189.1,192.9,0.8916008614501078,-0.16553008438077144,0.020837510038979618,1.6811541779319095,0.15248292257202703,0.8167787926977439,1067]
["High","O75820-1","Zinc finger protein 189 [OS=Homo sapiens]",9,5,9,1,626,72.9,8.5,7.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF189","ENSG00000136870; ENSGGOG00000003650; ENSPPAG00000034345; ENSPPYG00000019452; ENSPTRG00000021200","","Generic Transcription Pathway","Herpes simplex virus 1 infection",129.8,113.1,125.1,129.5,142,160.4,0.8520490854364436,-0.23099155026264676,0.10648687974499127,0.9727038983789135,0.32516603717203435,0.4878948217466135,2557]
["High","O75821","Eukaryotic translation initiation factor 3 subunit G [OS=Homo sapiens]",56,22,117,22,320,35.6,6.13,228.78,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3G","ENSG00000130811","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",4340.1,5696.4,4324.5,4463.7,4291.8,4530.1,1.0809447823207081,0.11229282806170766,0.4795552892959538,0.31916131455819485,0.6822827439545931,0.1660356125982548,5488]
["High","O75822","Eukaryotic translation initiation factor 3 subunit J [OS=Homo sapiens]",40,8,12,8,258,29,4.83,19.73,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3J","ENSG00000104131","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",539.9,474.4,586,1608.4,510.5,463.9,0.6195988849310824,-0.6905935471218003,0.4321984958925438,0.36431674885191,0.650714588493826,0.1866094566266073,5186]
["High","O75828","Carbonyl reductase [NADPH] 3 [OS=Homo sapiens]",35,6,16,4,277,30.8,6.18,47,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CBR3","ENSG00000159231","Nuclear receptors meta-pathway; NRF2 pathway","Phase I - Functionalization of compounds","Arachidonic acid metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways",215.9,222.7,224.9,270.1,242.5,272.4,0.8452229299363057,-0.24259618840879613,0.015377309716599114,1.813119638359965,0.13325863958624404,0.8753046246803925,901]
["High","O75832","26S proteasome non-ATPase regulatory subunit 10 [OS=Homo sapiens]",52,10,64,10,226,24.4,6.1,103.3,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PSMD10","ENSG00000101843","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway","Degradation of DVL; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","",1983,2287,2245.5,2173.9,2139.3,2187.8,1.002230426088294,3.214241423721809E-3,0.9623612676243946,0.016661864466524647,0.9799317654683454,0.008804164013914258,7668]
["High","O75844","caax prenyl protease 1 homolog [OS=Homo sapiens]",16,7,48,7,475,54.8,7.49,80.53,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZMPSTE24","ENSG00000084073","Adipogenesis; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy","","Terpenoid backbone biosynthesis",1767.6,1344.7,1836.7,1751,1859.6,1847.1,0.9067922384887407,-0.1411560522225639,0.3424252878884662,0.46543417044088725,0.5826229348078327,0.23461242347691116,4589]
["High","O75864-1","Protein phosphatase 1 regulatory subunit 37 [OS=Homo sapiens]",9,4,5,4,691,74.7,5.06,9.53,"other biological processes","","enzyme regulator activity","PPP1R37","ENSG00000104866; ENSPPAG00000031033","","","",129.8,99.9,140.8,112.9,116.8,118.8,1.0631276901004303,0.08831488643741056,0.5843683505811932,0.23331331351145065,0.7542979139259309,0.12245709336016601,6049]
["Medium","O75865-1","Trafficking protein particle complex subunit 6A [OS=Homo sapiens]",6,1,1,1,159,17.6,5.26,0,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC6A","ENSG00000007255","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",13.6,10.9,17.8,16.5,13.5,18.3,0.875776397515528,-0.19136552571582327,0.45970331168775036,0.3375223675950565,0.6671679289327054,0.17576483860281022,5380]
["High","O75874","Isocitrate dehydrogenase [NADP] cytoplasmic [OS=Homo sapiens]",73,28,435,27,414,46.6,7.01,794.24,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","IDH1","ENSG00000138413","Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism","Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration","Citrate cycle (TCA cycle); Glutathione metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Peroxisome; Central carbon metabolism in cancer",14161.3,13357.3,14147.3,14493.7,14094.8,14528.3,0.9663495435653849,-0.04938296632987544,0.18211955030489516,0.739643430735601,0.42120540544449686,0.375506064030583,3376]
["High","O75879","Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial [OS=Homo sapiens]",13,5,11,5,557,61.8,8.63,16.71,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","other molecular function","GATB","ENSG00000059691","","","Aminoacyl-tRNA biosynthesis; Metabolic pathways",264.9,313.6,269.8,291.6,277.5,275.7,1.0041429924242424,0.005964727229146515,0.9463009991280643,0.023970701369747015,0.9713051401593171,0.01264431296613088,7607]
["High","O75880","Protein SCO1 homolog, mitochondrial [OS=Homo sapiens]",8,3,5,3,301,33.8,8.88,9.23,"cell organization and biogenesis;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO1","ENSG00000133028","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","",320.5,341.6,359.6,364.3,351.6,337.1,0.970275403608737,-0.04353379395155433,0.490607650497097,0.3092656837228517,0.6905831143106784,0.16078404494305176,5547]
["High","O75882-1","Attractin [OS=Homo sapiens]",5,6,10,6,1429,158.4,7.31,11.5,"cell adhesion;stress response;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","ATRN","ENSG00000088812","","","",243.9,229.1,251.3,213.1,218.4,216.7,{"$f":"AVERAGE(T706:V706)/AVERAGE(W706:Y706)","v":1.1174020364085155},{"$f":"LOG(Z706,2)","v":0.16014835464548632},{"$f":"TTEST(T706:V706,W706:Y706,2,2)","v":0.019434358381730056},{"$f":"-LOG10(AB706)","v":1.7114297928703202},{"$f":"AB706*7808/AF706","v":0.14804240999468127},{"$f":"-LOG10(AD706)","v":0.8296138536034577},1025]
["High","O75884-1","Putative hydrolase RBBP9 [OS=Homo sapiens]",6,2,3,2,186,21,6.2,7.2,"other biological processes","nucleus","other molecular function","RBBP9","ENSG00000089050; ENSPPAG00000038694; ENSPTRG00000013289","","","",247.2,168.5,293.5,266.4,312.1,272.7,0.8331766917293233,-0.263305614602501,0.2936352369156201,0.5321918292744733,0.5376885388923925,0.2694692206343537,4264]
["High","O75886","Signal transducing adapter molecule 2 [OS=Homo sapiens]",17,8,16,7,525,58.1,5.07,18.11,"cell organization and biogenesis;other metabolic processes;transport;signal transduction","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STAM2","ENSG00000115145","EGF/EGFR signaling pathway","Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell","Endocytosis; JAK-STAT signaling pathway",539.8,429.2,476.9,439.2,430.8,462.1,1.085429021845207,0.11826538861550513,0.3190664013705202,0.49611892588367545,0.5614763267750782,0.25066854994159493,4437]
["High","O75907","Diacylglycerol O-acyltransferase 1 [OS=Homo sapiens]",10,4,6,4,488,55.2,9.32,20.93,"cell organization and biogenesis;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","DGAT1","ENSG00000185000; ENSG00000285482","Triacylglyceride synthesis; Statin inhibition of cholesterol production; Glycerolipids and glycerophospholipids; Congenital generalized lipodystrophy (CGL); Vitamin A and carotenoid metabolism","Neutrophil degranulation; Acyl chain remodeling of DAG and TAG; Triglyceride biosynthesis","Glycerolipid metabolism; Retinol metabolism; Metabolic pathways; Fat digestion and absorption",334.7,344.2,310.1,255,272.1,265.3,1.2481070166582533,0.31974164075698663,0.004412123112486492,2.3553523778439103,0.06987800661723029,1.1556594924625045,493]
["High","O75909","Cyclin-K [OS=Homo sapiens]",18,7,20,7,580,64.2,8.41,44.16,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNK","ENSG00000090061","Male infertility","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes","",810.1,819.9,830.8,799.5,799.4,804.6,1.0238402329935512,0.03399060493656874,0.0372668068187862,1.4286778178818424,0.19398615176072173,0.7122292722788883,1500]
["High","O75915","PRA1 family protein 3 [OS=Homo sapiens]",20,3,9,3,188,21.6,9.77,6.29,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","ARL6IP5","ENSG00000144746","","Glutamate Neurotransmitter Release Cycle","",108.4,108.7,110.5,106.9,110.7,116.4,0.9808383233532935,-0.027912745720405873,0.4939619973683085,0.30630646194295225,0.6923093296449027,0.1596998157437597,5571]
["High","O75923-1","dysferlin [OS=Homo sapiens]",16,24,35,24,2080,237.1,5.64,65.88,"cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYSF","ENSG00000135636","","Smooth Muscle Contraction","",808.1,786.3,843.7,884.2,916.2,875,0.9113029827315543,-0.13399730539073368,0.01928044011072095,1.7148830567674211,0.1478798392775139,0.8300910301095256,1018]
["High","O75925","E3 SUMO-protein ligase PIAS1 [OS=Homo sapiens]",11,5,9,4,651,71.8,7.3,16,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS1","ENSG00000033800","Androgen receptor signaling pathway; Interleukin-11 signaling pathway; Mesodermal commitment pathway; TGF-beta signaling pathway; Immune response to tuberculosis; Interferon type I signaling pathways","SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway; Hepatitis C",203.5,217.2,207,195.2,210,189.5,1.0554901631074491,0.07791313320687673,0.20947405911943076,0.678869751594284,0.45131717814694133,0.345518135940424,3624]
["High","O75928-1","E3 SUMO-protein ligase PIAS2 [OS=Homo sapiens]",10,4,7,3,621,68.2,7.52,10.59,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS2","ENSG00000078043; ENSPTRG00000009998","Androgen receptor signaling pathway; TGF-beta signaling pathway","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway",34.2,24.7,37.5,38.1,29.7,24.5,1.0444203683640303,0.06270249858418733,0.8164940892767962,0.08804695483884134,0.8977870509890473,0.046826662828951114,7101]
["High","O75934","Pre-mRNA-splicing factor spf27 [OS=Homo sapiens]",48,10,26,10,225,26.1,5.66,64.74,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","","BCAS2","ENSG00000116752","","mRNA Splicing - Major Pathway","Spliceosome",1060.3,1079.6,1273.3,1218.6,1133.7,1107.7,0.9864739884393064,-0.01964708473363304,0.8470098296744077,0.07211154958832135,0.9152301065731768,0.03846970216168937,7226]
["High","O75935","Dynactin subunit 3 [OS=Homo sapiens]",24,4,11,4,186,21.1,5.47,18.4,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DCTN3","ENSG00000137100","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection",299.4,192.5,309.4,276.3,273.5,294.5,0.9490702356982114,-0.07541323741546818,0.7250954517305295,0.1396048190411169,0.8438731982578587,0.07372280625835086,6709]
["High","O75937","DnaJ homolog subfamily C member 8 [OS=Homo sapiens]",16,4,8,4,253,29.8,9.06,12.9,"","non-structural extracellular;cytosol;nucleus","other molecular function","DNAJC8","ENSG00000126698; ENSG00000285317","mRNA processing","mRNA Splicing - Major Pathway","",491.5,343.2,540.7,1255.9,544.5,430.9,0.6164119571550217,-0.6980332473744774,0.34208799968562903,0.4658621604297373,0.5825568378506851,0.23466169577714185,4585]
["High","O75940","Survival of motor neuron-related-splicing factor 30 [OS=Homo sapiens]",37,7,16,7,238,26.7,7.24,32.33,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","SMNDC1","ENSG00000119953","","mRNA Splicing - Major Pathway","Spliceosome",782,934.9,771.8,941.3,822.8,778.3,0.9788782252989302,-0.030798698474753233,0.8152892603059286,0.08868827854018232,0.8968411587022669,0.047284468893120955,7098]
["High","O75943-1","cell cycle checkpoint protein RAD17 [OS=Homo sapiens]",9,6,8,6,681,77,7.06,13.11,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","RAD17","ENSG00000152942; ENSG00000276618","miRNA regulation of DNA damage response; Gastric cancer network 2; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","",210.4,195.1,265,233.2,233.8,221.1,0.9744223223368697,-0.03738091160634843,0.7994975914199979,0.09718284027869682,0.8882295381057689,0.05147478844331877,7028]
["High","O75947-1","ATP synthase subunit d, mitochondrial [OS=Homo sapiens]",41,6,20,6,161,18.5,5.3,16.06,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5PD","ENSG00000167863; ENSGGOG00000013716; ENSPTRG00000009628","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",460.2,503.6,530.2,744.8,500.7,463.6,0.8741442864665615,-0.19405666391521015,0.47268501379694283,0.325428166532424,0.676080708504585,0.17000145617974988,5459]
["High","O75953","dnaJ homolog subfamily B member 5 [OS=Homo sapiens]",30,8,18,8,348,39.1,9.04,37.35,"stress response;other biological processes","cytosol","other molecular function","DNAJB5","ENSG00000137094","","","",386.3,314.7,426.8,373.6,392.9,329.2,1.0292963402391164,0.0416584020992592,0.7912308553221754,0.1016967850675104,0.8836976853605415,0.0536962825378829,6991]
["High","O75954","tetraspanin-9 [OS=Homo sapiens]",14,2,3,2,239,26.8,7.68,9.46,"","plasma membrane;other membranes","","TSPAN9","ENSG00000011105","","","",29.2,47.6,29.2,23.7,22.9,28.2,1.4171122994652408,0.502954089562925,0.1768756317893439,0.752331995854542,0.4158521327946995,0.38106106679429186,3321]
["High","O75955","Flotillin-1 [OS=Homo sapiens]",34,13,37,12,427,47.3,7.49,78.73,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","FLOT1","ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules","Insulin signaling pathway",924.9,724.3,996,996.9,1135,988.9,0.8476031786721353,-0.23853909678803087,0.1675418350013777,0.7758767322587359,0.40437918012079044,0.39321121260481967,3235]
["High","O75962-1","Triple functional domain protein [OS=Homo sapiens]",5,12,14,12,3097,346.7,6.37,23.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;kinase activity;other molecular function","TRIO","ENSG00000038382","Microtubule cytoskeleton regulation; Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; G alpha (q) signalling events; DCC mediated attractive signaling","",378.7,356.9,351.9,325.7,336.4,315,1.1129874117285847,0.154437275393756,0.0232350373368824,1.6338566253073865,0.1590001503298666,0.7986024650669656,1141]
["High","O75964","ATP synthase subunit g, mitochondrial [OS=Homo sapiens]",39,4,21,4,103,11.4,9.64,39.98,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5MG","ENSG00000167283","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis",631,588.1,624.6,598.7,698.4,654.3,0.9448088551808957,-0.08190560849088636,0.3219021797906533,0.49227608243881277,0.5637981650528086,0.24887634192439634,4458]
["Low","O75969","A-kinase anchor protein 3 [OS=Homo sapiens]",1,1,1,1,853,94.7,6.18,0,"developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","AKAP3","ENSG00000111254","G protein signaling pathways","","",35.7,35,33.9,29.9,32.5,36.6,1.0565656565656565,0.07938242127996929,0.4076010132512124,0.38976474505603476,0.6334690906579352,0.19827457112653904,5024]
["High","O75970","multiple PDZ domain protein [OS=Homo sapiens]",11,16,24,16,2070,221.5,5.06,47.36,"","plasma membrane;other membranes;other cell component","other molecular function","MPDZ","ENSG00000107186","","","Tight junction",1210.3,1358.4,1133.5,1440,1353.4,1394.2,0.8840863501767121,-0.17774080797687167,0.08363968648715801,1.077587603749541,0.28845347707231883,0.5399242216071395,2264]
["High","O75976","Carboxypeptidase D [OS=Homo sapiens]",15,16,26,16,1380,152.8,6.05,45.84,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","CPD","ENSG00000108582","","Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle; RND1 GTPase cycle","",699.6,722.3,656.7,747.8,742,716.9,0.9419495173788918,-0.08627835243649445,0.11729022830911062,0.9307381683465912,0.34057348554761463,0.46778916591125735,2689]
["High","O76003","glutaredoxin-3 [OS=Homo sapiens]",36,11,67,11,335,37.4,5.39,164.17,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","GLRX3","ENSG00000108010","","Iron uptake and transport","",3359.9,3452,3346.4,3385.1,3507.9,3459.3,0.981260203046666,-0.027292344917214374,0.2552728222819978,0.592995420061591,0.5024376597877083,0.2989178158771062,3967]
["High","O76021","Ribosomal L1 domain-containing protein 1 [OS=Homo sapiens]",48,24,127,24,490,54.9,10.13,233.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RSL1D1","ENSG00000171490","","","",5815.6,5516.1,5715,6517.9,6465,6718.9,0.8652356637464598,-0.20883496258590314,0.00164521511165321,2.7837773100566987,0.0457147316433746,1.3399438253031433,281]
["High","O76024","Wolframin [OS=Homo sapiens]",18,14,33,14,890,100.2,8.05,64.28,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","WFS1","ENSG00000109501","CAMKK2 pathway","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes","Protein processing in endoplasmic reticulum",1247.3,996,1434.1,1179.5,1300.2,1231.3,0.9909458367016977,-0.013121890409348518,0.9362910379879044,0.028589133585022308,0.9661108001334158,0.014973062893954087,7567]
["High","O76031","ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial [OS=Homo sapiens]",39,20,48,20,633,69.2,7.58,90.67,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","CLPX","ENSG00000166855","","","",2368.3,2525.2,2289,2422.2,2394,2405.8,0.9945306009415673,-0.00791233252875398,0.8597235132039718,0.06564119526349788,0.9216972663870124,0.0354117005591329,7283]
["High","O76039-1","Cyclin-dependent kinase-like 5 [OS=Homo sapiens]",3,2,2,1,1030,115.5,9.54,2.72,"","","","CDKL5","","","","",13.4,14.8,14.3,22.2,23.9,26.5,0.5853994490358126,-0.7725067069706867,1.5878248342001296E-3,2.7991974098033126,0.04524721279355697,1.3444081679650652,274]
["High","O76041-2","Isoform 2 of Nebulette [OS=Homo sapiens]",10,3,3,2,270,31.2,8.31,7.4,"","","","NEBL","","","","",108,78.6,94.5,115.6,105.2,109.5,0.8510445049954586,-0.23269351590518225,0.14305453986797945,0.8444983552070129,0.3730694212722724,0.428210346555411,2994]
["High","O76062","Delta(14)-sterol reductase [OS=Homo sapiens]",5,2,3,2,418,46.4,8.87,8.9,"other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","TM7SF2","ENSG00000149809","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Steroid biosynthesis; Metabolic pathways",230.8,175.1,243.2,207.7,215.2,209.1,1.0270569620253165,0.038516197773463545,0.8001191370284692,0.09684534213080387,0.8885407796783227,0.0513226354075227,7031]
["High","O76064","E3 ubiquitin-protein ligase RNF8 [OS=Homo sapiens]",11,4,5,4,485,55.5,7.33,9.64,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","RNF8","ENSG00000112130","ATM signaling in development and disease ; 3q29 copy number variation syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome","Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Nonhomologous End-Joining (NHEJ)","",122.1,142.2,115.8,146.8,132,120.6,0.9516775162744116,-0.07145530758200702,0.5898939816090409,0.22922603469594274,0.7576726778094082,0.12051837342174837,6079]
["High","O76070","Gamma-synuclein [OS=Homo sapiens]",76,8,15,7,127,13.3,4.86,35.71,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","cytoskeleton;other cell component","other molecular function","SNCG","ENSG00000173267","","","",579.8,442.5,567.2,614.5,568.4,604.7,0.8891810248377714,-0.1694509333696715,0.22453187588658222,0.6487219952444112,0.4683796117879866,0.3294020177001977,3743]
["High","O76071","Probable cytosolic iron-sulfur protein assembly protein Ciao1 [OS=Homo sapiens]",33,8,19,8,339,37.8,4.97,62.4,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","","CIAO1","ENSG00000144021","","Cytosolic iron-sulfur cluster assembly","",644.7,590.1,665.9,635,610.1,632.8,1.012141221577294,0.01741059977028615,0.7667767311606326,0.115331074826146,0.8676801038988724,0.061640360904765906,6900]
["High","O76074","cGMP-specific 3',5'-cyclic phosphodiesterase [OS=Homo sapiens]",8,6,8,6,875,99.9,6.09,8.24,"other metabolic processes;signal transduction","cytosol","other molecular function","PDE5A","ENSG00000138735","Phosphodiesterases in neuronal function","cGMP effects; RHOBTB1 GTPase cycle","Purine metabolism; Metabolic pathways; cGMP-PKG signaling pathway",73.9,53.6,69.6,80.7,78.9,77.3,0.8319966230476993,-0.26535042219674576,0.10117815614050628,0.994913239389797,0.31688690057965224,0.49909571323493507,2493]
["High","O76075","DNA fragmentation factor subunit beta [OS=Homo sapiens]",12,3,4,3,338,39.1,9,5.11,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DFFB","ENSG00000169598","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis","Apoptosis induced DNA fragmentation","Apoptosis",125.5,128,151.7,159.7,151.1,155.6,0.8687821612349914,-0.2029336143993583,0.07918174477646102,1.1013749327626396,0.282048842707394,0.5496756779163356,2192]
["High","O76080","AN1-type zinc finger protein 5 [OS=Homo sapiens]",29,4,5,4,213,23.1,8.51,17.66,"developmental processes;signal transduction;other biological processes","other cell component","nucleic acid binding activity;other molecular function","ZFAND5","ENSG00000107372","","","",341.1,283,369.6,305.8,327.4,310.9,1.052536807541574,0.0738706856709469,0.5637210149549572,0.2489357748146239,0.739256581250975,0.13120480046669447,5954]
["High","O76094","Signal recognition particle subunit SRP72 [OS=Homo sapiens]",36,20,56,20,671,74.6,9.26,128.38,"transport","cytosol;ER/Golgi;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","SRP72","ENSG00000174780","","SRP-dependent cotranslational protein targeting to membrane","Protein export",2129.8,1615.7,2278,2171,2504.1,2328.6,0.860045404571869,-0.21751526853596426,0.21597922653925353,0.6655880184473503,0.4585007615058433,0.33865993869077354,3678]
["Medium","O76095-1","Protein JTB [OS=Homo sapiens]",9,1,2,1,146,16.3,8.28,2.18,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","other molecular function","JTB","ENSG00000143543; ENSGGOG00000005608; ENSPPAG00000028370; ENSPTRG00000001369","","","",39,37.2,40.9,45.2,36.3,43.3,0.9383012820512819,-0.09187685836103342,0.42749174133157486,0.3690722709446277,0.6474986452603175,0.18876113590552757,5155]
["High","O77932","Decapping and exoribonuclease protein [OS=Homo sapiens]",4,2,3,2,396,44.9,7.69,4.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","DXO","ENSG00000204348; ENSG00000206346; ENSG00000224313; ENSG00000225682; ENSG00000234798; ENSG00000236765","","","",84.9,66.5,81,87.4,81.7,103.5,0.8525311812179016,-0.23017549340068075,0.1941574048405995,0.7118460415326295,0.43562672902166694,0.3608854808205751,3480]
["High","O94760-1","N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [OS=Homo sapiens]",29,7,24,6,285,31.1,5.81,61.15,"other metabolic processes;signal transduction;other biological processes","cytosol","other molecular function","DDAH1","ENSG00000153904; ENSMFAG00000037521; ENSMMUG00000014573; ENSMNEG00000044101; ENSRBIG00000034663; ENSRROG00000009892","Mesodermal commitment pathway; Nitric oxide metabolism in cystic fibrosis","eNOS activation","",901.8,860.2,893.1,930.2,896.2,923,0.9657016076234815,-0.05035061566428003,0.12698730831158322,0.8962396822383734,0.3536080254268338,0.45147788687435897,2804]
["High","O94761","ATP-dependent DNA helicase Q4 [OS=Homo sapiens]",6,5,7,5,1208,133,8.09,14.84,"","","","","","","","",147,156.7,144,124.1,122,111.5,1.2519574944071588,0.3241855817202265,0.005347344589664247,2.2718618285109047,0.07760607166561048,1.1101042995186583,538]
["High","O94762-1","ATP-dependent DNA helicase Q5 [OS=Homo sapiens]",9,8,9,8,991,108.8,8.56,13.93,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RECQL5","ENSG00000108469","","","",383,377.3,378.2,391.4,388.5,404.5,0.9612462006079027,-0.057022104153569106,0.04301053001677171,1.366425205622123,0.2065351896500329,0.6850059422215371,1626]
["High","O94763-1","Unconventional prefoldin RPB5 interactor 1 [OS=Homo sapiens]",19,9,15,9,535,59.8,5.05,26.66,"other biological processes","cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","URI1","ENSG00000105176","","","",552.3,559.4,521.9,553.2,584.9,564.1,0.9596992127834567,-0.0593457851177136,0.19697069814308316,0.7055983757737894,0.4382864665435148,0.3582419393305601,3509]
["High","O94766","Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 [OS=Homo sapiens]",26,8,12,8,335,37.1,8.27,26.73,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","B3GAT3","ENSG00000149541","Proteoglycan biosynthesis","A tetrasaccharide linker sequence is required for GAG synthesis; Defective B3GAT3 causes JDSSDHD","Glycosaminoglycan biosynthesis; Glycosaminoglycan biosynthesis; Metabolic pathways",486.7,519,491.2,443.8,464.7,448.4,1.103176357874567,0.14166344395999583,0.017348538993290512,1.7607370934303814,0.1412485844208679,0.8500158959424097,959]
["High","O94768","Serine/threonine-protein kinase 17B [OS=Homo sapiens]",5,2,2,2,372,42.3,5.25,2.06,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus","kinase activity;other molecular function","STK17B","ENSG00000081320","","","",58.4,60.1,60,53.3,52,46.3,1.1774406332453826,0.23565432074537038,0.015595486888129208,1.8070010621042067,0.13425530498623248,0.8720685445056665,907]
["High","O94776","Metastasis-associated protein MTA2 [OS=Homo sapiens]",34,22,66,20,668,75,9.66,131.78,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MTA2","ENSG00000149480","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","",2390.7,2050.2,2337.7,2215.4,2237.8,2241.8,1.012486930545183,0.01790328542013105,0.8057921666807449,0.09377695881890326,0.8911650477964952,0.05004185521207165,7060]
["High","O94782","Ubiquitin carboxyl-terminal hydrolase 1 [OS=Homo sapiens]",11,7,7,7,785,88.2,5.45,13.61,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus","other molecular function","USP1","ENSG00000162607","miR-517 relationship with ARCN1 and USP1; DNA repair pathways, full network","Fanconi Anemia Pathway; Recognition of DNA damage by PCNA-containing replication complex","Fanconi anemia pathway",319.4,318.8,307.8,383.8,364.4,376.6,0.8410384068278803,-0.24975641084577807,9.3553938894203287E-4,3.0289379227122843,0.03689238155989592,1.43306330831518,198]
["High","O94788-1","retinal dehydrogenase 2 [OS=Homo sapiens]",5,5,11,2,518,56.7,6.05,23.03,"cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","ALDH1A2","ENSG00000128918","Ethanol effects on histone modifications; Tryptophan metabolism; 22q11.2 copy number variation syndrome; Vitamin A and carotenoid metabolism","RA biosynthesis pathway","Retinol metabolism; Metabolic pathways",421.5,593.3,386,438.5,410,423.4,1.101344445318028,0.13926574214183784,0.5419831541918786,0.2660142119029544,0.7231381524145913,0.14077872469759217,5852]
["High","O94804","Serine/threonine-protein kinase 10 [OS=Homo sapiens]",13,10,11,9,968,112.1,6.95,16.66,"cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","kinase activity;other molecular function","STK10","ENSG00000072786","","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation","Progesterone-mediated oocyte maturation",202.2,145.8,189.6,202.2,193.9,198.4,0.9042893187552566,-0.1451436718542577,0.33349408304000366,0.47691186707238625,0.574183417944068,0.24094935380986493,4535]
["High","O94808","Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [OS=Homo sapiens]",42,25,94,18,682,76.9,7.37,224.33,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","GFPT2","ENSG00000131459","","Synthesis of UDP-N-acetyl-glucosamine","Alanine, aspartate and glutamate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars; Insulin resistance; Diabetic cardiomyopathy",2641.9,2022.8,2760.1,1625.7,1771.2,1741.6,1.4449352924005059,0.5310048868967794,0.03072404797000382,1.5125215654888553,0.18010012503737977,0.7444859856645021,1332]
["High","O94819","Kelch repeat and BTB domain-containing protein 11 [OS=Homo sapiens]",6,2,3,2,623,65.7,6.07,7.41,"","","","KBTBD11","ENSG00000176595; ENSG00000273645","","","",40.7,34.9,41,39.9,43.3,37.7,0.9644334160463194,-0.05224645604862695,0.6065000663518766,0.21716914728503842,0.7681350394282972,0.11456242355815348,6165]
["High","O94822","E3 ubiquitin-protein ligase listerin [OS=Homo sapiens]",18,25,40,25,1766,200.4,6.25,71.97,"protein metabolism;other metabolic processes","cytosol;other cell component","translation activity;other molecular function","LTN1","ENSG00000198862","","Antigen processing: Ubiquitination & Proteasome degradation","",1839.4,1829,1898.3,1981.7,1911.7,1931.2,0.9557222813583764,-0.0653366414457587,0.04571497893894713,1.3399414759770465,0.21399433786288918,0.669597717620131,1668]
["High","O94826","Mitochondrial import receptor subunit TOM70 [OS=Homo sapiens]",48,25,95,25,608,67.4,7.12,193.99,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TOMM70","ENSG00000154174","Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation","Mitochondrial protein import; Ub-specific processing proteases; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PINK1-PRKN Mediated Mitophagy","",3566,3000.7,3545,3497.8,3403.8,3516,0.9706362309937031,-0.0429973822204646,0.6168530061096879,0.2098183144774431,0.7730960307711786,0.1117665564779773,6230]
["High","O94829","Importin-13 [OS=Homo sapiens]",10,7,10,7,963,108.1,5.3,17.08,"transport","nucleus;other cell component","other molecular function","IPO13","ENSG00000117408","","","Nucleocytoplasmic transport",335.4,324.2,339.9,302.5,317.1,307,1.0786747248003452,0.10925988459871837,0.018745345449141054,1.7271065517602568,0.14621743982706628,0.8350008245809402,1001]
["High","O94830","Phospholipase DDHD2 [OS=Homo sapiens]",14,6,6,6,711,81,5.39,5.24,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","DDHD2","ENSG00000085788","","Synthesis of PA","",116.6,115.4,127.4,115.7,130.3,135.5,0.9420707732634338,-0.08609264821195098,0.3549693720504435,0.4498091177148188,0.5914641180046656,0.22807159731712734,4686]
["High","O94832","Unconventional myosin-Id [OS=Homo sapiens]",8,7,8,7,1006,116.1,9.39,14.9,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1D","ENSG00000176658","","","Pathogenic Escherichia coli infection",346.6,247.1,347.3,264.6,300.5,308.5,1.0771520146520148,0.10722186669604689,0.5655512576788926,0.24752802748781144,0.7404131824206561,0.130525857610133,5964]
["High","O94842","TOX high mobility group box family member 4 [OS=Homo sapiens]",9,4,7,4,621,66.2,5.06,12.49,"other biological processes","nucleus;other cell component","nucleic acid binding activity","TOX4","ENSG00000092203","","","",249.6,228.2,237.1,217.6,243,233.7,1.0296701713956504,0.042182280810777864,0.5169797973248955,0.2865264280506415,0.7080474052820179,0.14993766439613807,5701]
["High","O94854","Uncharacterized protein KIAA0754 [OS=Homo sapiens]",9,7,11,7,1291,135.1,4.21,28.81,"","","","KIAA0754","","","","",200.7,180.3,209.5,197.7,163.4,179.6,1.0921028296652486,0.12710870320252013,0.27541518261386044,0.5600121223809348,0.5228402007899399,0.28163102723147443,4113]
["High","O94855","Protein transport protein Sec24D [OS=Homo sapiens]",18,15,33,15,1032,112.9,7.25,62.42,"cell organization and biogenesis;transport;developmental processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC24D","ENSG00000150961","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",1228.8,1112.5,1256.2,1348.2,1492.3,1417.2,0.8449397562064026,-0.24307961328027533,0.022125532614471023,1.6551062659977476,0.1552166744418596,0.8090616256738206,1113]
["Low","O94856","Neurofascin [OS=Homo sapiens]",1,1,2,1,1347,149.9,6.65,0,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","NFASC","ENSG00000163531","","Neutrophil degranulation; Neurofascin interactions; Interaction between L1 and Ankyrins","Cell adhesion molecules",100.3,66.5,79.4,105,100,106.8,0.7896087235407313,-0.34079016621332725,0.09532519898752755,1.0207922794810425,0.3088378231097988,0.5102695173972756,2410]
["High","O94864-1","STAGA complex 65 subunit gamma [OS=Homo sapiens]",17,3,9,3,414,46.2,5.12,0,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SUPT7L","ENSG00000119760; ENSPTRG00000011777","","HATs acetylate histones","",57,38.5,54.6,55.7,54.3,53.9,0.9158023184868822,-0.12689187747877048,0.47449754260378224,0.3237660324176807,0.6773083752560022,0.16921355409247604,5470]
["High","O94874-1","E3 UFM1-protein ligase 1 [OS=Homo sapiens]",16,11,28,11,794,89.5,6.79,48.52,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UFL1","ENSG00000014123","","Antigen processing: Ubiquitination & Proteasome degradation","",1467,1335,1476.9,1312.5,1415,1346.3,1.0503461141931365,0.07086480879539271,0.28013161005535325,0.5526378826150413,0.5266717099234766,0.2784600090662841,4153]
["High","O94875-1","Sorbin and SH3 domain-containing protein 2 [OS=Homo sapiens]",1,1,1,1,1100,124,8.31,2.53,"cell organization and biogenesis;developmental processes;signal transduction","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SORBS2","ENSG00000154556","Extracellular vesicles in the crosstalk of cardiac cells","","",44.8,42.6,41.3,37.4,33,41.8,1.1470588235294117,0.19793937761190883,0.11496111032349834,0.9394490503275554,0.3371962244199381,0.4721172968075763,2662]
["High","O94876","Transmembrane and coiled-coil domains protein 1 [OS=Homo sapiens]",15,7,9,6,653,72,6.55,15.21,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TMCC1","ENSG00000172765","","","",275.5,191.7,263.7,256.8,218,233.3,1.032198841971473,0.04572091716944809,0.803019596591851,0.09527385623083555,0.8896108130234354,0.05079994697619163,7048]
["High","O94880","PHD finger protein 14 [OS=Homo sapiens]",14,9,18,9,888,100,5.33,23.63,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF14","ENSG00000106443","","","",496.2,464.7,493,555.1,538.2,542.8,{"$f":"AVERAGE(T770:V770)/AVERAGE(W770:Y770)","v":0.8886376138377851},{"$f":"LOG(Z770,2)","v":-0.170332886525303},{"$f":"TTEST(T770:V770,W770:Y770,2,2)","v":0.005622994887052846},{"$f":"-LOG10(AB770)","v":2.2500323113911387},{"$f":"AB770*7808/AF770","v":0.07997148283808492},{"$f":"-LOG10(AD770)","v":1.0970648511825951},549]
["High","O94885","SAM and SH3 domain-containing protein 1 [OS=Homo sapiens]",7,6,7,6,1247,136.6,6.09,16.32,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","SASH1","ENSG00000111961","","","",236.4,280,210.6,327.3,265,292.2,0.8219332956472585,-0.2829067787708638,0.12494389999452117,0.9032849421256666,0.3511742156793453,0.4544773788686279,2778]
["High","O94887-1","FERM, RhoGEF and pleckstrin domain-containing protein 2 [OS=Homo sapiens]",6,4,6,4,1054,119.8,8.79,7.26,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity","FARP2","ENSG00000006607","","RAC1 GTPase cycle; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Rap1 signaling pathway; Adherens junction",162.4,153.5,167.1,142.8,148.5,133.5,1.1370056497175143,0.18523942291898207,0.03054167421247774,1.5151071597710388,0.17970564600680194,0.745438277976839,1327]
["High","O94888","UBX domain-containing protein 7 [OS=Homo sapiens]",41,15,50,15,489,54.8,5.16,88.4,"","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","UBXN7","ENSG00000163960","3q29 copy number variation syndrome","Neddylation","",1851.5,1979.1,1756.8,2011.9,1839.6,1967.7,0.9601663458894693,-0.05864372488674134,0.40236349644904845,0.395381426584967,0.6293377764972297,0.20111619860069915,4992]
["High","O94889","Kelch-like protein 18 [OS=Homo sapiens]",8,4,7,3,574,63.6,5.6,13.5,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","","","KLHL18","ENSG00000114648","","","",59.1,81.3,64.2,53.9,53,57.9,1.241504854368932,0.3120899025621102,0.12607241608528927,0.8993799241515797,0.35307511649710854,0.4521328889189162,2788]
["High","O94898","Leucine-rich repeats and immunoglobulin-like domains protein 2 [OS=Homo sapiens]",2,1,1,1,1065,118.9,5.55,3.51,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","LRIG2","ENSG00000198799","","","Axon guidance",56.9,53.2,59.4,47.7,51.9,60.7,1.0573923892701185,0.08051084786915812,0.508843041142839,0.2934161604487903,0.7014559437223317,0.15399960047186753,5664]
["High","O94901-1","SUN domain-containing protein 1 [OS=Homo sapiens]",28,15,51,14,812,90,7.08,133.9,"","","","","","","","",1902.1,1836.5,1997.1,1698.3,1756.3,1761.3,1.0996568185739757,0.13705335703184787,0.027033287395070132,1.5681011385140984,0.17077338833390582,0.7675798046082599,1236]
["High","O94903","Pyridoxal phosphate homeostasis protein [OS=Homo sapiens]",42,11,47,11,275,30.3,7.5,93.29,"","cytosol;other cell component","other molecular function","PLPBP","ENSG00000147471","","","",2458.3,2524,2396.3,2115.7,2138,2148,1.1526000906009342,0.20489203824128846,1.0271841724033032E-3,2.9883516811471704,0.038745188493357445,1.4117822219454528,207]
["High","O94905-1","Erlin-2 [OS=Homo sapiens]",52,18,80,15,339,37.8,5.62,160.07,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ERLIN2","ENSG00000147475; ENSGGOG00000012855; ENSPPAG00000034728; ENSPTRG00000020158","","ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions","",3370.7,3047.2,3475.7,3332.9,3695.8,3558.8,0.9344604486422667,-0.09779449218519946,0.23780728405304274,0.6237748470445185,0.48531084001206426,0.31398000807716014,3826]
["High","O94906-1","Pre-mRNA-processing factor 6 [OS=Homo sapiens]",48,43,144,43,941,106.9,8.25,301.32,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PRPF6","ENSG00000101161; ENSGGOG00000016876; ENSPPAG00000008686; ENSPTRG00000013765","mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",6111.4,5179.8,6025.7,5843.1,5738.8,5869.5,0.992292881946434,-0.011162090235008922,0.8884156075554261,0.05138382043462021,0.9381591917490895,0.027723462013072797,7394]
["High","O94913","Pre-mRNA cleavage complex 2 protein Pcf11 [OS=Homo sapiens]",10,12,21,12,1555,172.9,8.48,42.05,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCF11","ENSG00000165494","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",835,814.9,807,858.9,815.9,786.3,0.9982934460200723,-0.002464140156489145,0.9537091019860477,0.02058407253652845,0.9745531564333282,0.011194467561170606,7641]
["High","O94915-1","protein furry homolog-like [OS=Homo sapiens]",4,9,9,9,3013,339.4,5.58,17.4,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","","FRYL","ENSG00000075539","","","",363.9,337.6,347.6,361.3,360.6,395,0.9392962664517861,-0.09034782015379665,0.17428751005125523,0.7587337345777612,0.41262488734996994,0.3844445812276257,3298]
["High","O94916","nuclear factor of activated T-cells 5 [OS=Homo sapiens]",2,4,5,4,1531,165.7,5.24,8.46,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFAT5","ENSG00000102908","Cancer immunotherapy by PD-1 blockade","","",368,328.4,365.7,384.6,382,405.2,0.9063833418672128,-0.14180674832117232,0.06869371270617702,1.1630830105673466,0.2626643040204849,0.5805989436596027,2042]
["High","O94919","endonuclease domain-containing 1 protein [OS=Homo sapiens]",21,6,10,6,500,55,5.71,10.9,"other metabolic processes","non-structural extracellular;cytosol","nucleic acid binding activity;other molecular function","ENDOD1","ENSG00000149218","","Platelet degranulation","",141.8,192.3,162.6,138.4,131.8,140.9,1.2082218438336174,0.27288537487330106,0.12805822081342288,0.8925925363731695,0.3551966565226309,0.44953113090189906,2815]
["High","O94921-1","Cyclin-dependent kinase 14 [OS=Homo sapiens]",4,2,3,1,469,53,8.92,4.72,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CDK14","ENSCATG00000032271; ENSCSAG00000012501; ENSG00000058091; ENSGGOG00000003585; ENSMLEG00000038830; ENSMNEG00000032203; ENSPANG00000022338","","","Transcriptional misregulation in cancer",18.4,14.5,22.4,26.2,16.7,21.9,0.8533950617283952,-0.2287143326499175,0.42517389287985224,0.3714334104853183,0.6470001472628896,0.1890956204820677,5131]
["High","O94923","D-glucuronyl C5-epimerase [OS=Homo sapiens]",2,1,2,1,617,70.1,8.97,0,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GLCE","ENSG00000138604","","HS-GAG biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",37.2,36.8,44.8,24.2,29,24.9,1.5211267605633805,0.6051403826587867,0.010669740533117839,1.9718461416256976,0.11182460950682428,0.9514626097153549,745]
["High","O94925-1","Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",27,17,56,1,669,73.4,7.77,116.85,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","GLS","ENSG00000115419; ENSGGOG00000007590; ENSPTRG00000012747","Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling","Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer",68.5,77.4,65.6,40.8,38.3,39.9,1.777310924369748,0.8296960898120063,1.0474314093011556E-3,2.979874407060802,0.03821656282160478,1.4177483757513574,214]
["High","O94925-3","Isoform 3 of Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",36,19,69,3,598,65.4,7.88,154.85,"","","","GLS","","","","",3066.4,3095.4,3004.2,2717.2,2686.9,2851.2,1.1103170084672878,0.15097164166418564,6.058513992149378E-3,2.2176338847692554,0.0824126781371121,1.0840059725085935,574]
["High","O94927","HAUS augmin-like complex subunit 5 [OS=Homo sapiens]",8,4,6,4,633,71.6,8.51,17.88,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","","HAUS5","ENSG00000249115","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",193.3,178.7,228.6,208.5,209.5,215.6,0.9479166666666666,-0.07716786052245997,0.5034155950190929,0.29807333482295534,0.6976693230225555,0.15635037281407452,5634]
["High","O94941-1","RING finger protein 37 [OS=Homo sapiens]",3,1,4,1,541,58.9,7.56,12.27,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","UBOX5","ENSG00000185019","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",90.9,96,81,68.9,62.4,73.4,1.3087445041524182,0.3881834788189684,0.01794539911012112,1.7460468784064842,0.14297722066512827,0.8447331494403437,980]
["High","O94952-1","Isoform 2 of F-box only protein 21 [OS=Homo sapiens]",12,6,7,6,621,71.4,6.01,18.46,"","","","FBXO21","","","","",369.2,261.7,395.7,276.4,355.3,303,1.0983203166791484,0.13529886663017965,0.5506758436609097,0.25910397417219233,0.7299960929209479,0.13667946430065853,5890]
["High","O94953","lysine-specific demethylase 4B [OS=Homo sapiens]",17,12,19,12,1096,121.8,7.09,55.62,"cell organization and biogenesis;protein metabolism;other metabolic processes","nucleus","other molecular function","KDM4B","ENSG00000127663","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Estrogen-dependent gene expression; HDMs demethylate histones","",1032.9,1225.9,961.1,957.2,877,965.8,1.1499642857142856,0.2015890562801022,0.17086550845084575,0.7673455967367008,0.4088623628514262,0.38842286586594027,3263]
["High","O94964-2","Isoform 2 of Protein SOGA1 [OS=Homo sapiens]",11,17,21,14,1661,183.7,6.52,48.57,"","","","SOGA1","","","","",789.9,687.1,787.8,917.5,873.1,877.1,0.8489710237283055,-0.23621278096402493,0.021718522620856346,1.6631697204935012,0.15486595856040763,0.810044035011003,1095]
["High","O94966-6","Isoform 6 of Ubiquitin carboxyl-terminal hydrolase 19 [OS=Homo sapiens]",18,15,26,15,1384,151.8,6.42,56.32,"","","","USP19","","","","",756.7,619.2,804.7,770.9,721.1,705.1,0.9924901005871377,-0.010875382460552481,0.9302266655277082,0.031411215323797925,0.962779666548296,0.01647309039443448,7544]
["High","O94967-1","WD repeat-containing protein 47 [OS=Homo sapiens]",3,3,4,3,919,101.9,5.94,7.7,"","cytoskeleton;other cell component","","WDR47","ENSG00000085433","","","",272.5,285.3,271.6,196.9,226.1,212.3,1.3055249488430662,0.3846300281051732,2.4517306976862994E-3,2.6105272351862165,0.05377279013352423,1.2694374285004564,356]
["High","O94973","AP-2 complex subunit alpha-2 [OS=Homo sapiens]",28,21,51,12,939,103.9,6.96,100.25,"transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","AP2A2","ENSG00000183020","Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission","Neutrophil degranulation; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; Potential therapeutics for SARS; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease",945.9,775.8,996.5,891.6,963.9,937.4,0.9732536073615238,-0.039112307960130044,0.7400631017687556,0.1307312484020004,0.8513942387815594,0.0698692929348317,6787]
["High","O94979","Protein transport protein Sec31A [OS=Homo sapiens]",21,23,58,23,1220,132.9,6.89,119.61,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC31A","ENSG00000138674","Sterol regulatory element-binding proteins (SREBP) signaling","COPII-mediated vesicle transport; Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; XBP1(S) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum",2458.2,1924.8,2530.7,2404.2,2639.6,2585.2,0.9062393498492596,-0.14203595936615704,0.30709124887537886,0.5127325593930917,0.5503255614457099,0.2593803146702102,4357]
["Low","O94983","Calmodulin-binding transcription activator 2 [OS=Homo sapiens]",1,1,1,1,1202,131.4,7.3,0,"stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CAMTA2","ENSG00000108509","","","",35.1,37.6,30.9,27.3,30.1,25.8,1.2451923076923075,0.3163685695454615,0.043077516850002336,1.3657493390189763,0.20660273437642399,0.6848639349135234,1628]
["High","O94985-1","Calsyntenin-1 [OS=Homo sapiens]",1,1,2,1,981,109.7,4.91,2.37,"cell adhesion;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CLSTN1","ENSG00000171603","Splicing factor NOVA regulated synaptic proteins","","",36.4,38,39.3,42.7,42.5,41.3,0.8988142292490119,-0.15390513068942457,0.010728509638415226,1.9694606042938176,0.11213949565829462,0.9502414014505811,747]
["High","O94986-1","Isoform 1 of Centrosomal protein of 152 kDa [OS=Homo sapiens]",5,4,4,4,1275,147.3,5.43,4.51,"","","","CEP152","","","","",56.1,14.8,39.8,38.7,39.1,40.5,0.9357565511411664,-0.09579485155823637,0.843408352499182,0.07396210236509297,0.9133609453971724,0.039357562425886616,7210]
["High","O94992","Protein HEXIM1 [OS=Homo sapiens]",13,4,5,4,359,40.6,4.89,3.94,"stress response;developmental processes;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","HEXIM1","ENSG00000186834","Initiation of transcription and translation elongation at the HIV-1 LTR","","",212.8,180.9,248.2,400.8,219.9,171.1,0.810684516291993,-0.3027875063774381,0.5287112151927078,0.2767814771026496,0.7153313408810713,0.14549274675267695,5771]
["High","O95049-1","Tight junction protein ZO-3 [OS=Homo sapiens]",3,2,2,2,919,101.3,6.76,5.46,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","TJP3","ENSG00000105289","1q21.1 copy number variation syndrome","","Tight junction",87.4,90.7,76.4,89.8,80.4,89.3,0.9807321772639693,-0.02806888228218529,0.7685747780866093,0.11431387165092866,0.8687075661986459,0.06112639588771444,6908]
["High","O95057","GTP-binding protein Di-Ras1 [OS=Homo sapiens]",11,2,2,2,198,22.3,8.72,5.66,"signal transduction","plasma membrane;other membranes","other molecular function","DIRAS1","ENSG00000176490","","","",73.3,65.9,78.3,103.7,92.6,92.4,0.7533772081745755,-0.40855570661252916,0.010224076284182875,1.9903759188026464,0.10995810967892547,0.9587727348441047,726]
["High","O95059","Ribonuclease P protein subunit p14 [OS=Homo sapiens]",16,1,2,1,124,13.7,7.75,3.51,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP14","ENSG00000163684","","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","",5.9,4.6,6.3,10.9,18,14.8,0.38443935926773454,-1.3791720467218382,0.013291113483056465,1.8764386338586039,0.12458224979076217,0.9045438306067559,833]
["High","O95067","G2/mitotic-specific cyclin-B2 [OS=Homo sapiens]",26,8,14,8,398,45.3,8.9,33.23,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","CCNB2","ENSG00000157456","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response","Resolution of Sister Chromatid Cohesion; Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint","FoxO signaling pathway; Cell cycle; Oocyte meiosis; p53 signaling pathway; Cellular senescence; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection",822.9,602.8,831.4,657.5,732.3,703.8,1.0780951471150173,0.10848450852967399,0.5228853208870108,0.2815935500755921,0.7110220455391466,0.148116933577444,5742]
["High","O95071","E3 ubiquitin-protein ligase UBR5 [OS=Homo sapiens]",18,35,63,35,2799,309.2,5.85,149.28,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBR5","ENSG00000104517","Mesodermal commitment pathway","","Ubiquitin mediated proteolysis",2173.7,1960.7,2135.4,2257.1,2340.5,2335.7,0.904302424530887,-0.14512276316927722,0.03556438826539501,1.4489846570982328,0.19071891729134904,0.7196062274166157,1456]
["High","O95104","Splicing factor, arginine/serine-rich 15 [OS=Homo sapiens]",20,22,77,19,1147,125.8,9.55,162.91,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SCAF4","ENSG00000156304","","","",3499.1,3011.1,3359.5,3268.7,3307.3,3292.8,1.0000911964980546,0.000131562736550504,0.9984540785980968,0.000671904624089351,0.999093867191329,0.000393706880989092,7803]
["High","O95125","Zinc finger protein 202 [OS=Homo sapiens]",3,2,4,1,648,74.7,5.97,8.5,"other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF202","ENSG00000166261","","Generic Transcription Pathway","",81.4,81.6,80.4,84.8,93.5,89.5,0.9088872292755789,-0.1378267926105821,0.03289164008698129,1.4829144706046917,0.18516072516160773,0.7324511270193413,1387]
["High","O95139","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [OS=Homo sapiens]",20,2,4,2,128,15.5,9.63,9.65,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB6","ENSG00000165264","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",42.1,41.5,44.1,53.6,40.1,58.7,0.8379265091863516,-0.2551043777905984,0.21573130145440916,0.6660868365262637,0.4583482997975583,0.33880437528784196,3675]
["High","O95140","Mitofusin-2 [OS=Homo sapiens]",17,11,15,11,757,86.3,6.98,31.41,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion","other molecular function","MFN2","ENSG00000116688","Intracellular trafficking proteins involved in CMT neuropathy","Factors involved in megakaryocyte development and platelet production; PINK1-PRKN Mediated Mitophagy; RHOT2 GTPase cycle","Mitophagy; NOD-like receptor signaling pathway; Parkinson disease; Pathways of neurodegeneration",534.3,452.4,582.8,492.6,553.4,520.6,1.0018511426018128,0.00266816543547946,0.9827041556447365,7.577207406038523E-3,0.9903141516874163,0.004227014794476353,7748]
["High","O95149","Snurportin-1 [OS=Homo sapiens]",8,3,5,3,360,41.1,6.64,11.4,"transport","cytosol;nucleus","nucleic acid binding activity;other molecular function","SNUPN","ENSG00000169371","","snRNP Assembly","Nucleocytoplasmic transport",397.5,371.4,391.5,419.4,466.9,440.7,0.8744536548605879,-0.19354617005955815,0.024775032794623945,1.6059857619682254,0.16338129734833087,0.786797659696491,1184]
["High","O95155","Ubiquitin conjugation factor E4 B [OS=Homo sapiens]",26,26,68,24,1302,146.1,6.55,144.91,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","UBE4B","ENSG00000130939","","","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",2616.6,2073.1,2572,2469,2533.5,2471.8,0.9715558647632554,-0.041631141279807486,0.7069803983918668,0.1505926272048838,0.8320926968109278,0.079828289729712,6634]
["High","O95159","Zinc finger protein-like 1 [OS=Homo sapiens]",19,4,10,4,310,34.1,8.07,28.64,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","ZFPL1","ENSG00000162300","","","",657.2,953.1,701.3,750.2,733.5,744.8,1.0372896567197667,0.052818814075586064,0.7790399741825369,0.10844025719074347,0.8749631930979932,0.05801021597271809,6952]
["High","O95163","Elongator complex protein 1 [OS=Homo sapiens]",27,25,68,25,1332,150.2,5.94,159.43,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","ELP1","ENSG00000070061","","HATs acetylate histones","",2144.5,1978.6,2188.7,2154.8,2329.8,2274.4,0.9338363663263797,-0.09875832243798478,0.14395862078527819,0.8417623228152668,0.3739284468035436,0.4272114944075207,3006]
["High","O95166","Gamma-aminobutyric acid receptor-associated protein [OS=Homo sapiens]",12,2,4,1,117,13.9,8.79,3.78,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAP","ENSG00000170296","","Macroautophagy; TBC/RABGAPs","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse",187.4,105.7,190.6,273.4,210.9,213.7,0.6929799426934098,-0.5291144986511519,0.10685358710637782,0.9712108938615713,0.3260307964543173,0.4867413750901214,2559]
["High","O95169","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [OS=Homo sapiens]",18,3,8,3,186,21.8,6.8,10.96,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;ER/Golgi","transporter activity","NDUFB8","ENSG00000166136","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Mitochondrial protein import; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",349.6,375.1,396.4,413.8,405.8,419.7,0.9046235778261923,-0.14461049647537566,0.049243836536902424,1.3076481189840357,0.22406519561779378,0.6496255978380869,1716]
["Low","O95183","vesicle-associated membrane protein 5 [OS=Homo sapiens]",6,1,1,1,116,12.8,7.85,2.25,"transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP5","ENSG00000168899","","","SNARE interactions in vesicular transport",114.3,103.5,114.7,116.2,112.7,125.5,0.9382054176072235,-0.09202426327910392,0.2401408430811218,0.6195339689882072,0.48752462370707206,0.3120034442320328,3846]
["High","O95197","Reticulon-3 [OS=Homo sapiens]",4,4,12,3,1032,112.5,4.96,24.88,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","RTN3","ENSG00000133318","Alzheimer's disease and miRNA effects; Alzheimer's disease","Synaptic adhesion-like molecules","Alzheimer disease",793.8,877.4,853.2,715.8,819.4,833.5,1.0657322582007007,0.09184503820692164,0.3097246022458197,0.5090242961116122,0.5527610729909395,0.25746254881130876,4375]
["High","O95202-1","mitochondrial proton/calcium exchanger protein [OS=Homo sapiens]",41,30,98,30,739,83.3,6.7,215.37,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;translation activity;other molecular function","LETM1","ENSG00000168924","","RHOG GTPase cycle; Mitochondrial calcium ion transport","",4564.1,3348.9,4344.6,4553.5,4254,4415.7,0.9269768286042712,-0.1093948182539415,0.4488445794213538,0.34790401530978826,0.6594991486868518,0.1807857607254116,5314]
["High","O95208-1","epsin-2 [OS=Homo sapiens]",7,4,5,4,641,68.4,7.52,11.18,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","EPN2","ENSG00000072134","","Cargo recognition for clathrin-mediated endocytosis","Endocytosis",256.9,233,221.5,215.4,215.3,201.5,1.1252768111357165,0.17027993915735185,0.08155671874508094,1.0885402554241963,0.2850469382102023,0.5450836195451513,2234]
["High","O95210","Starch-binding domain-containing protein 1 [OS=Homo sapiens]",4,2,2,2,358,39,5.73,4.4,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STBD1","ENSG00000118804","Exercise-induced circadian regulation","Neutrophil degranulation; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","",137.9,132.8,154.1,159.3,159.7,147,0.9115879828326181,-0.13354618873748883,0.14727149908860776,0.8318812924389953,0.3782552187117925,0.42221507138911374,3040]
["High","O95218-1","Zinc finger Ran-binding domain-containing protein 2 [OS=Homo sapiens]",42,19,63,19,330,37.4,10.01,123.1,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRANB2","ENSANAG00000018241; ENSCANG00000036472; ENSCATG00000025001; ENSG00000132485; ENSGGOG00000023501; ENSMFAG00000003326; ENSMLEG00000036639; ENSMNEG00000042080; ENSNLEG00000009455; ENSPANG00000013398; ENSPPAG00000037049; ENSPTRG00000000856; ENSSBOG00000013268","","","",3006.9,2941.4,2895,3516.6,3316.7,3410,0.8633252955590484,-0.2120238345982247,2.1407039108515893E-3,2.669443397523769,0.05111503405482939,1.2914513455254195,327]
["High","O95219","sorting nexin-4 [OS=Homo sapiens]",26,9,22,9,450,51.9,5.99,41.35,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX4","ENSG00000114520","","","Endocytosis",767.2,683.8,776.8,788.6,781,754.3,0.9586471018546411,-0.06092826828050268,0.36407452184911443,0.4388097121879953,0.5978325692109118,0.22342042880279261,4755]
["High","O95229","ZW10 interactor [OS=Homo sapiens]",12,3,4,3,277,31.3,5.15,8.19,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","ZWINT","ENSG00000122952","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",129.8,176.3,147.9,169.8,138.3,148.9,0.9934354485776805,-0.009501867767154734,0.954287462998093,0.020320781702171553,0.9747614483371415,0.011101655426511422,7644]
["High","O95232-1","Luc7-like protein 3 [OS=Homo sapiens]",50,23,92,23,432,51.4,9.79,185.6,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","LUC7L3","ENSCANG00000028098; ENSCATG00000034891; ENSG00000108848; ENSGGOG00000024399; ENSMLEG00000034172; ENSMMUG00000010117; ENSPPAG00000025115; ENSPTRG00000009409; ENSRROG00000039925","","","",5760.1,5801.6,5539.9,5538.8,5307.7,5487.4,1.0470004101898505,0.06626200748242449,0.07549037716669788,1.122108404791366,0.27607909363820937,0.5589664794937733,2135]
["High","O95235","kinesin-like protein KIF20A [OS=Homo sapiens]",20,15,33,15,890,100.2,6.92,63.4,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF20A","ENSG00000112984","","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Mitotic Telophase/Cytokinesis","",1152.1,856.8,1120.5,971.8,978.6,949,1.0793267572601226,0.11013169495905892,0.4606803412053975,0.33660032017228364,0.6677171160445041,0.17540749105960318,5387]
["High","O95237","lecithin retinol acyltransferase [OS=Homo sapiens]",23,4,9,4,230,25.7,7.46,16.73,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LRAT","ENSG00000121207","Vitamin A and carotenoid metabolism","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events","Retinol metabolism; Metabolic pathways; Vitamin digestion and absorption",403.8,465,403.8,293.6,299.7,306.4,1.4144714904968323,0.5002630986618148,3.8932038712222285E-3,2.409692853454058,0.06637147560371869,1.1780185267992915,458]
["High","O95239-1","Chromosome-associated kinesin KIF4A [OS=Homo sapiens]",48,55,162,55,1232,139.8,6.27,329.66,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","KIF4A","ENSG00000090889; ENSGGOG00000006631; ENSPTRG00000021996","Retinoblastoma gene in cancer","MHC class II antigen presentation; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",7452.8,6620.6,7132.5,6658,6389.5,6713.3,1.073129630379337,0.1018243592346498,0.14002593127575189,0.8537915302708965,0.36911629689435205,0.4328367797974507,2962]
["High","O95243-2","Isoform 2 of Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",9,5,6,5,574,65.3,8.84,2.68,"","","","MBD4","","","","",218.6,172.5,212.2,212.8,211.7,205.5,0.9576190476190476,-0.062476246248133145,0.5749822533964588,0.24034555943372587,0.7471228880877934,0.12660795878832914,6009]
["High","O95248-1","Myotubularin-related protein 5 [OS=Homo sapiens]",4,6,7,6,1867,208.2,6.9,14.6,"","","","","","","","",275.8,273.7,275.4,252.5,268.1,233.1,1.0944672946795806,0.13022884395827833,0.07940758517750064,1.1001380108802925,0.28208117609914696,0.5496258943091289,2198]
["High","O95249-1","Golgi SNAP receptor complex member 1 [OS=Homo sapiens]",27,8,14,8,250,28.6,9.42,28.62,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","GOSR1","ENSG00000108587","","Intra-Golgi traffic; COPI-mediated anterograde transport","SNARE interactions in vesicular transport",626.1,491,601.5,700,635.7,618.8,0.8793041698644155,-0.1855657845278691,0.17921380369633533,0.7466285424514097,0.41895250876077433,0.37783520460433884,3340]
["High","O95251-1","Histone acetyltransferase KAT7 [OS=Homo sapiens]",17,11,25,11,611,70.6,8.85,39.46,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KAT7","ENSAMEG00000012243; ENSANAG00000032052; ENSCANG00000040077; ENSCATG00000030056; ENSCJAG00000007037; ENSDLEG00000005028; ENSECAG00000010150; ENSG00000136504; ENSGGOG00000007469; ENSMLEG00000043692; ENSMNEG00000044419; ENSPANG00000022824; ENSPCTG00005022544; ENSPPAG00000041097; ENSPPYG00000008925; ENSPTRG00000009383; ENSRFEG00010021504","Androgen receptor signaling pathway; Androgen receptor signaling pathway","HATs acetylate histones","",901.9,939.7,937.7,976.4,1062.2,1064.2,0.895739332216063,-0.1588491380875534,0.026531819087655645,1.5762329726845588,0.1691105660705431,0.7718292567264745,1225]
["Low","O95259","Potassium voltage-gated channel subfamily H member 1 [OS=Homo sapiens]",1,1,1,1,989,111.4,7.58,1.63,"transport;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","KCNH1","ENSG00000143473","","Voltage gated Potassium channels","",65.9,42.8,75.3,43.8,67.7,58,1.0855457227138643,0.11842049292066896,0.705206774296294,0.15168352447060496,0.8312582267067427,0.08026404358879329,6624]
["High","O95260-2","Isoform ATE1-2 of Arginyl-tRNA--protein transferase 1 [OS=Homo sapiens]",22,7,9,7,518,59,7.02,16.14,"","","","ATE1","","","","",206.3,248.3,194.5,242.3,241.5,231.2,0.9078321678321678,-0.1395024857151854,0.25902099084079794,0.5866650396371487,0.5058619050737745,0.2959680247606114,3998]
["High","O95271","Tankyrase-1 [OS=Homo sapiens]",1,2,3,2,1327,142,7.05,4.3,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","TNKS","ENSG00000173273","NAD+ biosynthetic pathways; Regulation of Wnt / B-catenin signaling by small molecule compounds","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; XAV939 stabilizes AXIN","",79.4,63.6,94.2,77.1,92.4,77.3,{"$f":"AVERAGE(T834:V834)/AVERAGE(W834:Y834)","v":0.9611021069692058},{"$f":"LOG(Z834,2)","v":-0.05723838460341424},{"$f":"TTEST(T834:V834,W834:Y834,2,2)","v":0.7690809127656134},{"$f":"-LOG10(AB834)","v":0.11402796693579949},{"$f":"AB834*7808/AF834","v":0.8689022958868339},{"$f":"-LOG10(AD834)","v":0.06102905524613298},6911]
["High","O95273-1","Cyclin-D1-binding protein 1 [OS=Homo sapiens]",9,4,10,4,360,40.2,4.82,21.8,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","","CCNDBP1","ENSG00000166946","","","",755.2,645.1,759.2,670.2,635.1,635.8,1.1125135232600072,0.15382287299730157,0.13639017388404762,0.8652169169350722,0.36595686518441367,0.4365701012623441,2910]
["High","O95292","Vesicle-associated membrane protein-associated protein B/C [OS=Homo sapiens]",48,11,35,10,243,27.2,7.3,61.69,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAPB","ENSG00000124164","Ciliary landscape","RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle; Sphingolipid de novo biosynthesis","Cholesterol metabolism; Amyotrophic lateral sclerosis; Pathways of neurodegeneration",1669.3,2036.1,1834.1,2107.3,2035.8,1891.1,0.9180173013821218,-0.12340675128860978,0.2532729580821176,0.5964111772945488,0.5001404291110708,0.30090803761356694,3954]
["Medium","O95294-1","RasGAP-activating-like protein 1 [OS=Homo sapiens]",1,1,1,1,804,90,6.51,0,"signal transduction;other biological processes","cytosol","enzyme regulator activity;other molecular function","RASAL1","ENSG00000111344","Ras signaling","Regulation of RAS by GAPs","Ras signaling pathway",13.5,15.6,11.4,15.3,15.1,16.3,0.8672376873661669,-0.20550064193767503,0.17845872818969108,0.748462206397469,0.41793813728407553,0.3788879972308201,3334]
["High","O95295","SNARE-associated protein Snapin [OS=Homo sapiens]",14,2,4,2,136,14.9,9.31,7.34,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SNAPIN","ENSG00000143553","","Golgi Associated Vesicle Biogenesis","",64.3,82.2,103.6,86.7,72.1,77.8,1.0570583262890954,0.08005498384118132,0.7294279843255533,0.13701757910143578,0.8452617544692669,0.0730087810879018,6738]
["High","O95297-1","Myelin protein zero-like protein 1 [OS=Homo sapiens]",13,3,6,3,269,29.1,8.72,11.85,"cell-cell signaling;signal transduction","plasma membrane;other membranes","other molecular function","MPZL1","ENSG00000197965","","","Cell adhesion molecules",157.2,186.4,172.4,224.5,192.4,215.4,0.8160683219990511,-0.29323815386337926,0.038300066349698014,1.4168004736741249,0.1955833342435854,0.7086681544278097,1529]
["High","O95298-1","NADH dehydrogenase [ubiquinone] 1 subunit C2 [OS=Homo sapiens]",24,4,14,4,119,14.2,8.98,25.51,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","NDUFC2","ENSG00000151366; ENSGGOG00000041901","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Neutrophil degranulation; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",763.5,885.6,899.4,826.7,979.9,968.8,0.9182460185919148,-0.12304735927500098,0.3128496588755085,0.5046643142314977,0.5559240183204301,0.2549845621573539,4394]
["High","O95299","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [OS=Homo sapiens]",22,7,18,7,355,40.7,8.48,37.43,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity","NDUFA10","ENSG00000130414","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",783.6,618.8,869.8,883.9,964.7,927.4,0.8185158501440921,-0.2889177408600479,0.09537902217534833,1.0205471342614232,0.3088840336562089,0.5102045399802414,2411]
["High","O95302","Peptidyl-prolyl cis-trans isomerase FKBP9 [OS=Homo sapiens]",7,5,8,4,570,63,5.08,9.64,"protein metabolism;other metabolic processes;other biological processes","ER/Golgi","other molecular function","FKBP9","ENSG00000122642","","Association of TriC/CCT with target proteins during biosynthesis","",293.7,370,277.7,293.1,258,268.5,1.1486090775988287,0.1998878686780071,0.25154737369477687,0.5993802126090356,0.49862449703194156,0.302226388759542,3939]
["High","O95336","6-phosphogluconolactonase [OS=Homo sapiens]",52,10,57,10,258,27.5,6.05,133.7,"other metabolic processes","cytosol;other cell component","other molecular function","PGLS","ENSG00000130313","Pentose phosphate metabolism","Pentose phosphate pathway","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism",2244.5,1962.7,2143.7,2114.8,2231.7,2194.6,0.9709223219336197,-0.04257221658986762,0.5172010384811556,0.28634061177659587,0.7078537613428332,0.1500564558721939,5705]
["High","O95340","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [OS=Homo sapiens]",16,9,11,8,614,69.5,8.03,20.58,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS2","ENSG00000198682","RANKL/RANK signaling pathway; Proteoglycan biosynthesis; Sulfation biotransformation reaction","Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Defective PAPSS2 causes SEMD-PA","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways",463.8,460.1,501.1,503.3,510.2,512.7,0.9336915214257633,-0.0989821124243157,0.06543165388351797,1.1842121021163128,0.2555729632428756,0.5924850915757943,1999]
["High","O95347-1","structural maintenance of chromosomes protein 2 [OS=Homo sapiens]",51,64,194,64,1197,135.6,8.43,396.49,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC2; SMC2L1","ENSG00000136824","Retinoblastoma gene in cancer","Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes","",8873,8234.9,8737.6,9143.2,9029.4,9191.8,0.9444935755945681,-0.08238711139111166,0.0645492773750325,1.1901086152688627,0.25352150791964473,0.5959851906715218,1988]
["High","O95352","Ubiquitin-like modifier-activating enzyme ATG7 [OS=Homo sapiens]",6,4,5,4,703,77.9,6.24,8.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","other molecular function","ATG7","ENSG00000197548","Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy","Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Macroautophagy","Autophagy; Autophagy; Ferroptosis; Neutrophil extracellular trap formation",361.6,282.7,337,342.9,338.6,327.7,0.9723543400713435,-0.04044594617236619,0.7152566671896242,0.14553808527360027,0.8361617094500055,0.07770972407969914,6679]
["High","O95359-3","Isoform 3 of Transforming acidic coiled-coil-containing protein 2 [OS=Homo sapiens]",8,15,28,12,2871,300.9,4.78,64.6,"","","","TACC2","","","","",523.2,531.6,512.3,559.7,498.1,494.1,1.0097944455183967,0.01406164682617246,0.8288066570104622,0.08154676931300854,0.904573997475215,0.04355590046732391,7154]
["High","O95363","phenylalanine--tRNA ligase, mitochondrial [OS=Homo sapiens]",8,4,5,4,451,52.3,7.46,10.62,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","FARS2","ENSG00000145982","","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",226.9,146.7,224.4,196.3,228.2,197.8,0.9609513096577215,-0.05746476180190652,0.788947593667408,0.10295184411245681,0.8817782438240941,0.05464062075544936,6986]
["High","O95365","Zinc finger and BTB domain-containing protein 7A [OS=Homo sapiens]",4,1,2,1,584,61.4,5.19,7.63,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB7A","ENSG00000178951","IL-18 signaling pathway","","",12,20.6,16.3,13.4,13.8,14.8,1.1642857142857144,0.2194451372861112,0.41257320494614835,0.38449898121480475,0.6377690723063802,0.19533654506851889,5051]
["High","O95372","acyl-protein thioesterase 2 [OS=Homo sapiens]",29,5,19,5,231,24.7,7.23,45.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;other cell component","other molecular function","LYPLA2","ENSG00000011009","","L1CAM interactions","Glycerophospholipid metabolism",720,711.7,628.5,679,649.8,646.8,1.0428224336910306,0.06049352426024465,0.4140030383961975,0.38299647155093625,0.6385886455546247,0.19477880771453626,5062]
["High","O95373","Importin-7 [OS=Homo sapiens]",43,36,155,35,1038,119.4,4.82,339.8,"stress response;transport;signal transduction;other biological processes","cytosol;nucleus","transporter activity;enzyme regulator activity;other molecular function","IPO7","ENSG00000205339","","","Nucleocytoplasmic transport",5305.9,5046.2,5808.8,4995.4,5451,5335,1.0240472961841154,0.03428234853570629,0.6547952645710606,0.1838944700329952,0.7992248594295516,0.09733101609192243,6397]
["High","O95376","E3 ubiquitin-protein ligase ARIH2 [OS=Homo sapiens]",31,11,24,11,493,57.8,5.63,55.14,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","ARIH2","ENSG00000177479","Modulators of TCR signaling and T cell activation","Antigen processing: Ubiquitination & Proteasome degradation","",499.6,714.7,498.6,561.3,489.7,563.2,1.0611448395490026,0.08562158842761784,0.686757922810659,0.16319632162257686,0.8194079861408351,0.08649980762720805,6544]
["High","O95379","Tumor necrosis factor alpha-induced protein 8 [OS=Homo sapiens]",19,3,6,3,198,23,7.93,13.26,"other biological processes","nucleus;other cell component","enzyme regulator activity","TNFAIP8","ENSG00000145779","","PI Metabolism","",97.9,82.5,81,86.2,85.2,89.5,1.0019164430816405,0.002762196977981196,0.9775010688637003,0.00988275904580082,0.9871092014598774,0.005634799743680814,7732]
["High","O95391","Pre-mRNA-splicing factor SLU7 [OS=Homo sapiens]",11,4,5,4,586,68.3,7.14,8.18,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLU7","ENSG00000164609","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","Spliceosome",81.9,98.2,88,69.6,76,70.5,1.2406293382693199,0.3110721471230541,0.028298864255773163,1.548230994063993,0.17370875165807928,0.7601783007177526,1272]
["High","O95394","phosphoacetylglucosamine mutase [OS=Homo sapiens]",32,16,28,16,542,59.8,6.25,48.67,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PGM3","ENSG00000013375","Glucuronidation","Synthesis of UDP-N-acetyl-glucosamine","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",1454.8,1134.3,1537.4,1649.7,1996,1772.8,0.7615576266494417,-0.39297488609888964,0.05392390432728888,1.2682186705081562,0.23261759391573014,0.6333574407187053,1810]
["High","O95396","Adenylyltransferase and sulfurtransferase MOCS3 [OS=Homo sapiens]",15,7,12,7,460,49.6,6.21,29.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","MOCS3","ENSG00000124217","","Molybdenum cofactor biosynthesis","Sulfur relay system",361,355,356,371.7,343.1,355.2,1.0018691588785045,0.00269410916926285,0.9412093344303412,0.026313774365240083,0.9681152000042292,0.014072961132357254,7591]
["High","O95400","CD2 antigen cytoplasmic tail-binding protein 2 [OS=Homo sapiens]",40,7,25,7,341,37.6,4.61,49.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","CD2BP2","ENSG00000169217","mRNA processing; Ciliary landscape","mRNA Splicing - Major Pathway","",728.3,720.9,674,733.5,641,631.4,1.0584774914003687,0.08199059065836603,0.3470139221594379,0.45965310101393997,0.5852018799613155,0.23269428737325779,4630]
["High","O95405-1","Zinc finger FYVE domain-containing protein 9 [OS=Homo sapiens]",2,1,1,1,1425,156.3,5.01,0,"transport;signal transduction","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ZFYVE9","ENSG00000157077","TGF-beta signaling pathway; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling","","Endocytosis; TGF-beta signaling pathway",13.2,24.9,14.8,29.5,27.6,29,0.6144018583042972,-0.7027455152828186,0.04050645909771136,1.3924757193327453,0.20106448355685333,0.6966646372973968,1573]
["High","O95409","Zinc finger protein ZIC 2 [OS=Homo sapiens]",6,3,6,2,532,55,8.41,13.67,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZIC2","ENSG00000043355","Mesodermal commitment pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Ciliopathies","","",122.8,154,143.2,156.5,165.6,135.8,0.9172308364271674,-0.12464323712006228,0.3763349824698974,0.4244254096697865,0.6079916290347526,0.2161024001500315,4833]
["High","O95425","Supervillin [OS=Homo sapiens]",11,16,21,16,2214,247.6,6.98,37.41,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SVIL","ENSG00000197321","","","",555.5,511.6,550.5,607.3,565.4,576.8,0.9246070305801657,-0.11308776222419727,0.0782052033308281,1.10676435048634,0.2804897692269664,0.552082974868799,2177]
["High","O95427","GPI ethanolamine phosphate transferase 1 [OS=Homo sapiens]",2,2,2,2,931,105.7,8.65,4.32,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","PIGN","ENSG00000197563","","Synthesis of glycosylphosphatidylinositol (GPI)","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways",128.7,113.7,113.4,135.7,122.3,133.3,0.9092767697418859,-0.13720859963363463,0.14378350724380004,0.8422909270532373,0.3737222451929397,0.42745105072673256,3004]
["High","O95433","activator of 90 kDa heat shock protein ATPase homolog 1 [OS=Homo sapiens]",71,19,96,19,338,38.3,5.53,234.42,"other biological processes","cytosol;ER/Golgi","other molecular function","AHSA1","ENSG00000100591","T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection","","",4429.7,4566.1,4409.8,4538.1,4497.1,4653.8,0.9792972459639125,-0.0301812675514284,0.23668530136203855,0.6258287118029382,0.4837797992237689,0.3153522700560115,3820]
["Medium","O95452","Gap junction beta-6 protein [OS=Homo sapiens]",2,1,1,1,261,30.4,8.51,1.99,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","transporter activity;cytoskeletal activity","GJB6","ENSG00000121742","Calcium regulation in cardiac cells","Gap junction assembly","",82.5,43.5,84.9,77.9,83.8,76.6,0.8850188837599665,-0.17621985639657936,0.538637071853396,0.2687037594516082,0.7213856358544282,0.1418325095519869,5830]
["High","O95453","poly(A)-specific ribonuclease PARN [OS=Homo sapiens]",16,9,20,9,639,73.4,6.2,38.49,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARN","ENSG00000140694; ENSG00000274829","Lung fibrosis","Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA","RNA degradation",846.1,707.6,881.9,892.4,937.2,943.7,0.8782317095157394,-0.1873264694012493,0.11262846836994235,0.9483518217999268,0.3348831230131416,0.47510673889475197,2626]
["High","O95456","Proteasome assembly chaperone 1 [OS=Homo sapiens]",46,10,26,10,288,32.8,7.17,55.54,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","PSMG1","ENSG00000183527","","","",970.6,757.5,999.9,1062.8,1329.7,1216.8,0.7558252292688332,-0.40387541866373566,0.053967337888426836,1.2678690043709753,0.23241973206444388,0.6337270038078485,1813]
["Medium","O95460","matrilin-4 [OS=Homo sapiens]",2,1,1,1,622,68.4,6.1,0,"","non-structural extracellular;extracellular matrix","other molecular function","MATN4","ENSG00000124159","","ECM proteoglycans","",66.2,73.6,89.1,77.7,72.4,71.8,1.031545741324921,0.04480779535867501,0.7557130689809658,0.12164306721289815,0.8597708935747312,0.06561726144493417,6863]
["High","O95470","sphingosine-1-phosphate lyase 1 [OS=Homo sapiens]",13,7,15,7,568,63.5,9.16,27.09,"other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","SGPL1","ENSG00000166224","Sphingolipid pathway; Kennedy pathway from sphingolipids; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",685.8,702,764.4,736.2,740.7,747.2,0.9676723168922259,-0.04740950485517362,0.37757405354449913,0.42299785756680747,0.6086082184301093,0.21566218737918671,4844]
["High","O95478","Ribosome biogenesis protein NSA2 homolog [OS=Homo sapiens]",24,5,21,5,260,30,10.27,29.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","NSA2","ENSG00000164346","","","",847,823.4,856.7,1005.1,1046.5,1039.8,0.8174613443747172,-0.29077758396770736,3.142630948075699E-4,3.5027066169540695,0.023822973245218503,1.623004037000606,103]
["High","O95479","GDH/6PGL endoplasmic bifunctional protein [OS=Homo sapiens]",11,8,14,8,791,88.8,7.3,27.85,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","H6PD","ENSG00000049239","Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism","","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism",448,365.4,480.5,419.4,442.5,430.9,1.0008508663366338,1.227018703862093E-3,0.9921211107583594,3.4353091728837556E-3,0.9959477542814695,1.7634433256893092E-3,7778]
["High","O95486-1","Protein transport protein Sec24A [OS=Homo sapiens]",8,9,15,9,1093,119.7,7.66,32.26,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi","other molecular function","SEC24A","ENSG00000113615","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",559.2,487.2,613.2,497.4,547,565.2,1.0310636182902584,0.04413335206612316,0.7100931263927117,0.14868469124389536,0.834247236062939,0.0787052235279522,6646]
["High","O95487-1","Protein transport protein Sec24B [OS=Homo sapiens]",8,9,13,9,1268,137.3,6.67,27.89,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SEC24B","ENSG00000138802","Sterol regulatory element-binding proteins (SREBP) signaling","COPII-mediated vesicle transport; MHC class II antigen presentation; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",416.4,431.8,431.5,429.1,424.3,434.8,0.9934016457071883,-0.009550958086408368,0.657257174543728,0.18226466448710751,0.7997294715345844,0.09705689911966255,6417]
["High","O95490-1","Adhesion G protein-coupled receptor L2 [OS=Homo sapiens]",16,16,33,16,1459,163.2,6.43,61.6,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ADGRL2","ENSG00000117114","GPCRs, other; GPCRs, class B secretin-like","","",922.3,937.8,975.8,1017.3,929.9,936.5,0.9834240732392412,-0.024114423562690515,0.6474768296241148,0.1887757684767333,0.794390176886406,0.09996613479264184,6364]
["High","O95502","neuronal pentraxin receptor [OS=Homo sapiens]",2,1,2,1,500,52.8,6.21,4.73,"other biological processes","other membranes;other cell component","other molecular function","NPTXR","ENSG00000221890","","","",63.8,67.4,72.9,56.2,38.7,53.2,1.37812288993923,0.46270454174387116,0.03612658947151423,1.4421730360410174,0.19215014345611928,0.7163592869624337,1468]
["High","O95528","Solute carrier family 2, facilitated glucose transporter member 10 [OS=Homo sapiens]",4,2,2,2,541,56.9,8.59,2.24,"transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC2A10","ENSG00000197496","Nuclear receptors meta-pathway; NRF2 pathway","Cellular hexose transport; Defective SLC2A10 causes arterial tortuosity syndrome (ATS)","",21.4,18.4,31.1,19.9,20.8,21,1.1491085899513778,0.2005151380900984,0.4700390148988815,0.3278660925917874,0.6742723917564701,0.17116462225022575,5443]
["High","O95544","NAD kinase [OS=Homo sapiens]",4,1,2,1,446,49.2,6.47,2.77,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NADK","ENSG00000008130","NAD+ metabolism","Nicotinate metabolism","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors",22.2,24.3,35,28.8,45.5,43.1,0.6942078364565588,-0.5265604439916123,0.1416538227932799,0.8487717007367338,0.37140129226659824,0.43015658949425567,2978]
["High","O95551-1","Tyrosyl-DNA phosphodiesterase 2 [OS=Homo sapiens]",23,6,14,6,362,40.9,5.1,33.83,"DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TDP2","ENSG00000111802","Oxidative damage response","Nonhomologous End-Joining (NHEJ)","",446.2,1255.9,401.3,513.2,530.2,495.5,1.3668204561699915,0.4508237447690191,0.5354326396802808,0.2712951579885127,0.7191911320529214,0.14315567628626547,5813]
["High","O95562","Vesicle transport protein SFT2B [OS=Homo sapiens]",17,2,3,2,160,17.8,9.13,9.05,"transport","other membranes","","SFT2D2","ENSG00000213064","TYROBP causal network in microglia","","",78.1,78.9,77.8,109.4,96.1,94.4,0.7829276425475159,-0.3530491137586879,0.010299114847118873,1.9872000989385867,0.11015820373466323,0.9579831544004072,730]
["Medium","O95563","Mitochondrial pyruvate carrier 2 [OS=Homo sapiens]",8,1,1,1,127,14.3,10.43,2,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MPC2","ENSG00000143158","Glycolysis and gluconeogenesis","Pyruvate metabolism","Diabetic cardiomyopathy",31.2,18.4,28.5,22.6,26.8,25.9,1.037184594953519,0.052672683470050795,0.8310594635104029,0.08036790070382632,0.9060195882559657,0.042862412721075015,7162]
["Medium","O95568","histidine protein methyltransferase 1 homolog [OS=Homo sapiens]",3,1,1,1,372,42.1,6.76,2.2,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","METTL18","ENSG00000171806","","","",47.5,47.7,59.4,49.5,51.7,51.6,1.0117801047120418,0.016895775889098623,0.8879857093531298,0.051594023409483096,0.937832059871397,0.02787492494836507,7393]
["High","O95571","Persulfide dioxygenase ETHE1, mitochondrial [OS=Homo sapiens]",12,2,4,2,254,27.9,6.83,12.38,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","ETHE1","ENSG00000105755","","Sulfide oxidation to sulfate","Sulfur metabolism; Metabolic pathways",105.4,124,126.6,101.4,81.5,101,1.2539626629094753,0.3264943921293687,0.06221808075678394,1.2060833897170902,0.24849042176417854,0.6046903467903404,1955]
["High","O95573","long-chain-fatty-acid--CoA ligase 3 [OS=Homo sapiens]",34,19,75,16,720,80.4,8.38,200.86,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL3","ENSG00000123983","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Ciliary landscape; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway",3902.7,3934.1,3940.9,3942.2,4325.7,4345,0.9337820802511713,-0.0988421920866896,0.10203209033511508,0.9912632158497573,0.31828468291513323,0.4971842607993452,2503]
["High","O95602","DNA-directed RNA polymerase I subunit RPA1 [OS=Homo sapiens]",31,42,105,41,1720,194.7,7.03,243.35,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR1A","ENSG00000068654","Pyrimidine metabolism; Eukaryotic transcription initiation","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase",3796.9,3838.2,3806.4,3870.1,3882.4,3900.6,0.9818417416824707,-0.026437592638296644,0.00998147683014619,2.0008051970159793,0.10992294935089061,0.9589116275404104,709]
["High","O95613","Pericentrin [OS=Homo sapiens]",12,29,38,29,3336,377.8,5.55,73.09,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton","other molecular function","PCNT","ENSG00000160299","","Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy","",1164.5,1084.9,1178.3,1280.9,1223.6,1264.8,0.9093730931472687,-0.1370557771445641,0.02791683712211632,1.5541337872745935,0.1727216040011761,0.7626533375240737,1262]
["High","O95619","YEATS domain-containing protein 4 [OS=Homo sapiens]",30,7,12,7,227,26.5,8.41,24.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus","cytoskeletal activity;other molecular function","YEATS4","ENSG00000127337","","HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors","",580.9,596.1,578.9,731.2,729.4,697.6,0.8135946622185155,-0.29761788080519713,3.8794292926554077E-4,3.4112321592719694,0.026805826475268517,1.571770798096754,113]
["High","O95625","Zinc finger and BTB domain-containing protein 11 [OS=Homo sapiens]",6,6,6,6,1053,119.3,8.66,10.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB11","ENSG00000066422","","","",263.4,224.3,255.4,236.1,244.6,245.5,1.0232718259432663,0.033189439167311964,0.670633384661872,0.17351483084524683,0.8091957143316174,0.0919464260088189,6471]
["High","O95628-1","CCR4-NOT transcription complex subunit 4 [OS=Homo sapiens]",19,8,15,8,575,63.5,7.03,22.75,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CNOT4","ENSG00000080802","","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",304.6,304.8,318.9,279.2,289.4,273.7,1.1021013890537814,0.14025695236332453,0.012220981282787197,1.9128939210501146,0.11972574887829666,0.9218124377875915,797]
["High","O95630","STAM-binding protein [OS=Homo sapiens]",17,8,15,8,424,48,6.29,30.37,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","STAMBP","ENSG00000124356","EGF/EGFR signaling pathway","Metalloprotease DUBs","Endocytosis",852.5,849.3,878,836.1,903.9,829,1.0042039704165044,0.006052334249939744,0.894719644364588,0.048313027230877666,0.9404915163164651,0.02664511763998506,7428]
["High","O95639","Cleavage and polyadenylation specificity factor subunit 4 [OS=Homo sapiens]",13,3,11,3,269,30.2,8.31,18.7,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CPSF4","ENSG00000160917","mRNA processing","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA surveillance pathway; Influenza A",496.5,440.4,497.6,541.9,515.5,518.7,0.9101579848994353,-0.13581110534710544,0.08411705596333482,1.0751159357153006,0.2881904225369541,0.5403204562370407,2279]
["High","O95671-1","N-acetylserotonin O-methyltransferase-like protein [OS=Homo sapiens]",40,20,61,20,621,68.8,6.07,143.5,"other metabolic processes","cytosol","other molecular function","ASMTL","ENSG00000169093","","","Pyrimidine metabolism; Metabolic pathways",2615.1,2089.6,2548.4,2394.9,2546.6,2453.5,0.9808113590263693,-0.02795240754288752,0.7957617647070718,0.09921693195974786,0.886096386028639,0.05251903472286977,7012]
["High","O95674-1","phosphatidate cytidylyltransferase 2 [OS=Homo sapiens]",28,8,30,8,445,51.4,7.09,76.88,"cell organization and biogenesis;other metabolic processes","other membranes;mitochondrion;ER/Golgi","other molecular function","CDS2","ENSG00000101290","","Synthesis of PG","Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system",844.8,865.7,869.1,844.7,902.7,884.3,0.9802029106661094,-0.028847664118751223,0.4061274217149998,0.3913376859656424,0.6325639155696626,0.19889558592006074,5013]
["High","O95684","FGFR1 oncogene partner [OS=Homo sapiens]",29,6,8,6,399,43,4.81,15.09,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","CEP43","ENSG00000213066","Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",141.6,94.9,141.9,113.4,148.7,145.5,0.9283611383709518,-0.1072419628264188,0.6398692573913474,0.19390875506926739,0.789897100665872,0.10242948025848748,6325]
["High","O95696-2","Isoform 2 of Bromodomain-containing protein 1 [OS=Homo sapiens]",10,9,13,9,1189,133.2,8.59,26.54,"","","","BRD1","","","","",539.6,498.2,514.2,537.7,530.2,550.8,0.9587940940260703,-0.0607070725769354,0.17424131909675392,0.7588488497423818,0.4126406489255246,0.3844279922268994,3297]
["High","O95707","Ribonuclease P protein subunit p29 [OS=Homo sapiens]",6,1,2,1,220,25.4,10.07,3.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP4","ENSG00000105171","","tRNA processing in the nucleus","Ribosome biogenesis in eukaryotes",41.9,42.6,41.9,42.4,42.4,38.1,1.0284784377542717,0.04051154780444121,0.46678153676461276,0.33088633051832883,0.6723169597967342,0.17242593314028773,5421]
["High","O95714","E3 ubiquitin-protein ligase HERC2 [OS=Homo sapiens]",3,14,19,14,4834,526.9,6.28,37.23,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HERC2","ENSG00000128731","Prader-Willi and Angelman syndrome","SUMOylation of DNA damage response and repair proteins; Antigen processing: Ubiquitination & Proteasome degradation; Nonhomologous End-Joining (NHEJ); Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint","Ubiquitin mediated proteolysis",389,341.8,397.3,380.7,406.5,386.1,0.9614761783005197,-0.056676981340337725,0.47184987502130804,0.3261961556468356,0.6756287959226799,0.17029184867502142,5453]
["High","O95716","ras-related protein Rab-3D [OS=Homo sapiens]",41,8,19,5,219,24.3,4.93,39.34,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3D","ENSG00000105514","","Neutrophil degranulation; RAB geranylgeranylation","Pancreatic secretion",508.7,423.1,584.5,551.1,666.8,576.6,0.8449707439398162,-0.24302670414772032,0.1872337792615023,0.7276157964982514,0.4272125506936908,0.3693559970446975,3422]
["High","O95747","Serine/threonine-protein kinase OSR1 [OS=Homo sapiens]",37,16,61,14,527,58,6.43,137.72,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol","kinase activity;other molecular function","OXSR1","ENSG00000172939","","","",2106.9,1727.2,2120,2098.1,2092.5,2054.3,0.9534340021457508,-0.06879501798792505,0.4958794137759699,0.3046239208862991,0.6938757101725399,0.15871831516524246,5580]
["High","O95749","geranylgeranyl pyrophosphate synthase [OS=Homo sapiens]",17,5,9,5,300,34.8,6.14,16.5,"other metabolic processes","cytosol","other molecular function","GGPS1","ENSG00000152904","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Terpenoid backbone biosynthesis; Metabolic pathways",534.4,469,492.7,506.3,467.2,486.3,1.0248664200575421,0.03543588272668509,0.6146931545924368,0.2113416232859828,0.7713796449787441,0.11273182540003206,6222]
["High","O95754-1","Semaphorin-4F [OS=Homo sapiens]",2,1,2,1,770,83.5,6.95,5.43,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","SEMA4F","ENSG00000135622","","RND3 GTPase cycle","Axon guidance",34.2,23.8,26.9,22.2,23.3,22.8,{"$f":"AVERAGE(T898:V898)/AVERAGE(W898:Y898)","v":1.2430453879941437},{"$f":"LOG(Z898,2)","v":0.3138789752629483},{"$f":"TTEST(T898:V898,W898:Y898,2,2)","v":0.14873462211624897},{"$f":"-LOG10(AB898)","v":0.8275879256014019},{"$f":"AB898*7808/AF898","v":0.37988875678235917},{"$f":"-LOG10(AD898)","v":0.42034355966885534},3057]
["High","O95757","Heat shock 70 kDa protein 4L [OS=Homo sapiens]",31,19,58,14,839,94.5,5.88,120.14,"stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","HSPA4L","ENSG00000164070","","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",970.3,879.4,962.2,944.1,954.7,936.1,0.9918868390419413,-0.011752557002389379,0.8080302338983334,0.09257238901556167,0.8922500447289191,0.04951342160091248,7071]
["High","O95758-1","Isoform 1 of Polypyrimidine tract-binding protein 3 [OS=Homo sapiens]",9,6,44,2,521,56.5,9.22,71.01,"","","","PTBP3","","","","",154.1,137.4,162.7,168.6,175.9,151.6,0.9155412215279177,-0.12730325118579042,0.24826099139630808,0.6050915146469076,0.4969038248711545,0.3037276603000635,3901]
["High","O95772-1","STARD3 N-terminal-like protein [OS=Homo sapiens]",12,3,5,3,234,26.6,4.81,9.62,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STARD3NL","ENSCANG00000042172; ENSCATG00000036966; ENSCSAG00000015104; ENSG00000010270; ENSGGOG00000013471; ENSMFAG00000043802; ENSMLEG00000030425; ENSMMUG00000023659; ENSMNEG00000034363; ENSPANG00000016262; ENSPPAG00000039214; ENSPTRG00000019094; ENSRBIG00000036179; ENSRROG00000026971","","Pregnenolone biosynthesis","",346.7,303.6,363.4,382.6,378.2,401.1,0.8724502969274464,-0.1968551508645454,0.0613201567961212,1.212396743321851,0.24679782694026509,0.6076586685934416,1940]
["High","O95777","U6 snRNA-associated Sm-like protein LSm8 [OS=Homo sapiens]",52,3,17,3,96,10.4,4.48,40.09,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","LSM8","ENSG00000128534","","mRNA Splicing - Major Pathway","RNA degradation; Spliceosome",247.4,199.1,288.1,297.2,326,295.6,0.7995211144971701,-0.3227919606462664,0.0897794072444105,1.0468232662915886,0.29957162895912703,0.5234993190430961,2340]
["High","O95782-2","Isoform B of AP-2 complex subunit alpha-1 [OS=Homo sapiens]",40,31,81,22,955,105.3,7.66,182.32,"","","","AP2A1","","","","",3105.4,2885.3,3286,2880.4,3086.6,2867.6,1.050041880786906,0.07044687074722261,0.33907388374538033,0.4697056592990509,0.5796997775966564,0.23679686624741608,4567]
["High","O95785-3","Isoform 3 of Protein Wiz [OS=Homo sapiens]",19,12,21,3,965,102.9,9.52,51.56,"","","","WIZ","","","","",476.5,465.8,458,482.2,513.4,505.1,0.933097887652429,-0.09989965837309485,0.035870370584962244,1.4452641365057226,0.19170147400916168,0.717374547781384,1461]
["High","O95785-4","Isoform 4 of Protein Wiz [OS=Homo sapiens]",19,10,20,1,835,89.3,9.48,51.01,"","","","WIZ","","","","",18.2,19.3,16.7,19.5,11.7,18.6,1.0883534136546187,0.1221471092857909,0.5996151997532806,0.2221273666754789,0.7638759144515606,0.11697718336895355,6129]
["High","O95786","Probable ATP-dependent RNA helicase DDX58 [OS=Homo sapiens]",1,1,1,1,925,106.5,6.4,3.27,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","DDX58","ENSG00000107201","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Pathways of nucleic acid metabolism and innate immune sensing; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation","ISG15 antiviral mechanism; Ub-specific processing proteases; OAS antiviral response; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation","NF-kappa B signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease",40.1,38.3,35.8,44.6,47.3,56.9,0.76747311827957,-0.38181187574518843,0.042773653123870756,1.3688236568325682,0.2065409298646771,0.684993872080334,1617]
["High","O95789","Zinc finger MYM-type protein 6 [OS=Homo sapiens]",3,3,4,3,1325,148,8.22,0,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZMYM6","ENSG00000163867","","","",31.4,24,28.3,23.5,27.7,28.9,1.0449438202247192,0.06342538014163379,0.679573361481039,0.16776365332937973,0.8145699733564558,0.0890716028995986,6514]
["High","O95793","double-stranded RNA-binding protein Staufen homolog 1 [OS=Homo sapiens]",36,18,38,18,577,63.1,9.44,75.33,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","STAU1","ENSG00000124214","","","",1994.4,2107.3,2048.8,2063.9,1908.4,1873.9,1.0520509048612774,0.07320451300867867,0.20414391629233827,0.6900635579895054,0.44711239787112966,0.34958328751875434,3565]
["High","O95801","Tetratricopeptide repeat protein 4 [OS=Homo sapiens]",51,15,50,15,387,44.7,5.6,111.91,"stress response","nucleus;other cell component","other molecular function","TTC4","ENSG00000243725","","","",2399.5,2146.9,2414.1,2433.2,2322.8,2305.4,0.9857110488005212,-0.020763297733424065,0.7425299660502789,0.12928601497011136,0.8532264863753609,0.06893567137998907,6795]
["Medium","O95807","transmembrane protein 50A [OS=Homo sapiens]",6,1,1,1,157,17.4,5.87,2.4,"transport","other membranes;ER/Golgi;other cell component","","TMEM50A","ENSG00000183726","","","",51.4,32.1,60.2,54.7,59.5,62.8,0.811864406779661,-0.3006892985130234,0.26754273553677,0.5726068367253324,0.5133874856404768,0.28955472191998227,4069]
["High","O95816","BAG family molecular chaperone regulator 2 [OS=Homo sapiens]",37,8,19,8,211,23.8,6.7,30.16,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","BAG2","ENSG00000112208","Malignant pleural mesothelioma","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",589.2,585.3,711.6,868.7,766.6,726.4,0.7986196383960704,-0.3244195459964561,0.055536830787554746,1.2554189069182704,0.23631148489876155,0.6265151708477432,1835]
["High","O95817","BAG family molecular chaperone regulator 3 [OS=Homo sapiens]",2,1,1,1,575,61.6,6.95,2.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BAG3","ENSG00000151929","","Regulation of HSF1-mediated heat shock response","",11.7,12.8,16.5,34.1,14.5,13.4,0.6612903225806451,-0.5966443057687916,0.3664226681551313,0.4360176672362554,0.6004256438521018,0.2215407675519652,4765]
["High","O95819","Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",18,19,46,1,1239,142,7.46,103.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","cytoskeletal activity;kinase activity;other molecular function","MAP4K4","ENSG00000071054","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma","Oxidative Stress Induced Senescence","MAPK signaling pathway",37.3,39.3,31.6,47.6,34.1,38.5,0.9001663893510814,-0.1517363968843704,0.43322806997766056,0.3632834120618026,0.6512600636090824,0.18624555269645107,5194]
["High","O95819-3","Isoform 3 of Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",17,19,47,1,1320,150.9,7.42,106.24,"","","","MAP4K4","","","","",2257,2091.4,2254.2,2326.2,2372.1,2328.5,0.9396311265440883,-0.08983358953320789,0.06733269777138824,1.1717739846148458,0.26013543008362167,0.5848004934715145,2021]
["High","O95822","Malonyl-CoA decarboxylase, mitochondrial [OS=Homo sapiens]",14,5,7,5,493,55,8.95,19.9,"other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","MLYCD","ENSG00000103150","","","beta-Alanine metabolism; Propanoate metabolism; Metabolic pathways; Peroxisome; AMPK signaling pathway; Alcoholic liver disease",285.7,205.2,306.1,268.5,294.8,300.6,0.9225604815372151,-0.1162845999164423,0.5284705248403475,0.2769792302225252,0.7155016226726953,0.14538937697478707,5767]
["High","O95825-1","Quinone oxidoreductase-like protein 1 [OS=Homo sapiens]",22,6,16,6,349,38.7,5.78,20.08,"other metabolic processes","","other molecular function","CRYZL1","ENSG00000205758","","","",347.7,310.1,395.1,356.1,408.9,398.9,0.9046309820431309,-0.14459868826740324,0.27727117133811785,0.5570952828910528,0.524450897724812,0.28029516685157235,4128]
["High","O95831-1","Apoptosis-inducing factor 1, mitochondrial [OS=Homo sapiens]",29,16,46,16,613,66.9,8.95,115.94,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","AIFM1","ENSG00000156709","Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70","","Apoptosis; Necroptosis",1814.2,1784.8,1893.1,2075.2,2134.8,2172.2,0.8605339851461878,-0.21669592501156482,0.002300013579486487,2.63826959986126,0.05220495938555376,1.2822882377741545,344]
["High","O95834","echinoderm microtubule-associated protein-like 2 [OS=Homo sapiens]",6,4,5,4,649,70.6,6.32,10.72,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","EML2","ENSG00000125746","","","",300.3,288.8,277.8,322.4,367.8,324.1,0.8546781031253081,-0.2265469339145279,0.03878304771511137,1.4113580654520788,0.1974041959319358,0.7046436204064056,1534]
["Medium","O95857","Tetraspanin-13 [OS=Homo sapiens]",4,1,1,1,204,22.1,7.93,1.89,"other biological processes","plasma membrane;other membranes","other molecular function","TSPAN13","ENSG00000106537","","","",90.6,107.2,75.9,98.2,93.9,89.4,0.9722912966252223,-0.04053948760263515,0.7956101758208612,0.09929967090382702,0.8863067845354949,0.05241592622873599,7009]
["High","O95861-1","3'(2'),5'-bisphosphate nucleotidase 1 [OS=Homo sapiens]",47,11,21,11,308,33.4,5.69,35.66,"other metabolic processes;developmental processes","cytosol","other molecular function","BPNT1; HEL20","ENSG00000162813; ENSPTRG00000001996","","Cytosolic sulfonation of small molecules","Sulfur metabolism; Metabolic pathways",822.3,668.6,801,845.5,916.7,844.7,0.8791668264989068,-0.1857911446198253,0.12209126216990583,0.9133154165398294,0.34791553832942507,0.458526174701582,2740]
["High","O95863","Zinc finger protein SNAI1 [OS=Homo sapiens]",4,1,1,1,264,29.1,8.65,2.92,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SNAI1","ENSG00000124216","Neural crest differentiation; Mesodermal commitment pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Epithelial to mesenchymal transition in colorectal cancer; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; CCL18 signaling pathway","Regulation of PTEN gene transcription","Adherens junction",13.6,47.6,20.1,22.3,15,18.6,1.45438282647585,0.540407069231838,0.47039779237210255,0.3275347251182779,0.6742915298038143,0.17115229573277457,5447]
["High","O95864","fatty acid desaturase 2 [OS=Homo sapiens]",16,7,10,7,444,52.2,8.82,19.47,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","FADS2","ENSG00000134824","PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis","alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","alpha-Linolenic acid metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway",378.7,367,417.4,530.9,549.1,546.5,0.7150937596065171,-0.4837956814561574,6.8449094999910776E-4,3.164632289518934,0.032588447180445325,1.4869363329079963,164]
["High","O95865","N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [OS=Homo sapiens]",48,10,40,9,285,29.6,6.01,100.42,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion","other molecular function","DDAH2","ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076","Nitric oxide metabolism in cystic fibrosis","eNOS activation","",1316.5,1358.3,1327.6,1307.1,1364.5,1344.3,0.9966383625090268,-0.004857987716869867,0.8404255136495291,0.07550077174798417,0.9117746853655028,0.04011246977684182,7197]
["High","O95873","Uncharacterized protein C6orf47 [OS=Homo sapiens]",4,1,1,1,294,31.7,6.37,2.78,"","","","C6orf47","ENSG00000203623; ENSG00000204439; ENSG00000226103; ENSG00000226531; ENSG00000228177; ENSG00000228435; ENSG00000235360","","","",53.9,27,42.6,46.3,48.5,51.7,0.8430034129692832,-0.24638962283757043,0.38971218901553945,0.40925601058040817,0.6179676628418628,0.2090342501810514,4924]
["High","O95881","Thioredoxin domain-containing protein 12 [OS=Homo sapiens]",31,5,18,5,172,19.2,5.4,40.09,"other biological processes","ER/Golgi","other molecular function","TXNDC12","ENSG00000117862","","","Glutathione metabolism; Metabolic pathways",914.1,1087.1,1036.7,1008.3,921.9,909.8,1.0696830985915493,0.09718345101242322,0.3333434298011875,0.4771081003980524,0.5740506175314671,0.24104981152991556,4534]
["High","O95900","Mitochondrial mRNA pseudouridine synthase TRUB2 [OS=Homo sapiens]",8,3,6,2,331,36.7,8.98,11.66,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","TRUB2","ENSG00000167112","","","",221.1,177.5,211.2,188,196.3,164.8,1.1105445274084866,0.15126723906548406,0.2802183079129983,0.5525034937260234,0.5267078835302578,0.2784301812664683,4154]
["High","O95905","Protein ecdysoneless homolog [OS=Homo sapiens]",21,9,9,9,644,72.7,4.87,11.41,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ECD","ENSG00000122882","","","",253.1,258.9,277.6,300.7,276.7,301.8,0.8980891719745223,-0.1550693964928334,0.05369213581648329,1.2700893199171148,0.23213078430515036,0.6342672612359666,1806]
["High","O95983-1","methyl-CpG-binding domain protein 3 [OS=Homo sapiens]",29,8,27,8,291,32.8,5.34,30.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MBD3","ENSG00000071655; ENSPTRG00000010209","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; Regulation of TP53 Activity through Acetylation","",802.6,785.9,911.5,939.1,798.9,792.5,0.9879470460383324,-0.017494379459272454,0.8776215257158826,0.05669273321709756,0.9311684838686793,0.030971731484510306,7359]
["High","O95985","DNA topoisomerase 3-beta-1 [OS=Homo sapiens]",13,7,11,7,862,96.6,8.12,19.99,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP3B","ENSG00000100038","","","Homologous recombination; Fanconi anemia pathway",315.5,296.5,312.4,284.9,276,287.3,1.0898373025229897,0.12411277687119614,0.02035200694318591,1.6913927578699852,0.15177504318280383,0.8187996348901923,1047]
["High","O95989","Diphosphoinositol polyphosphate phosphohydrolase 1 [OS=Homo sapiens]",25,3,10,3,172,19.5,6.34,26.94,"cell-cell signaling;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT3","ENSG00000272325","","Synthesis of pyrophosphates in the cytosol","",460.9,555.4,486.6,477.8,547.6,502.2,0.9838308457711442,-0.023517806706136894,0.8248087198039122,0.08364675637790484,0.9031140771601384,0.044257388167112145,7131]
["High","O95995","Growth arrest-specific protein 8 [OS=Homo sapiens]",4,2,2,2,478,56.3,7.94,2.7,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","GAS8","ENSG00000141013","Ciliopathies","Activation of SMO","",39.8,29.1,39,34.2,35.9,35.3,1.023719165085389,0.03381999785080225,0.8223619114725933,0.08493701267314531,0.9013197367740046,0.045121118805715836,7124]
["High","O95997","Securin [OS=Homo sapiens]",7,1,1,1,202,22,6.6,2.33,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PTTG1","ENSG00000164611","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition","APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids","Cell cycle; Oocyte meiosis; Human T-cell leukemia virus 1 infection",29.7,22.6,19.3,27.3,22,20.5,1.0257879656160458,0.03673255105460412,0.8789477520493627,0.05603694025166398,0.9321956055421656,0.030492948703676498,7362]
["Medium","O95999","B-cell lymphoma/leukemia 10 [OS=Homo sapiens]",3,1,1,1,233,26.2,5.74,2.26,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BCL10","ENSG00000142867","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling","NF-kappa B signaling pathway; C-type lectin receptor signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway; Shigellosis; Tuberculosis",103.2,56.6,95.9,97.6,61.8,53.3,1.2021626704278328,0.26563212728097674,0.5100129836869138,0.2924187676828352,0.7022009128244442,0.15353861031019853,5671]
["High","O96000","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [OS=Homo sapiens]",19,3,3,3,172,20.8,8.48,6.91,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB10","ENSG00000140990","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Modulators of TCR signaling and T cell activation; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",34.7,47.5,57.9,69.6,47.9,55.8,0.8084246970571262,-0.30681469872935196,0.29677228351355694,0.5275766616113204,0.5412749333505846,0.26658208478699436,4281]
["High","O96005-1","Cleft lip and palate transmembrane protein 1 [OS=Homo sapiens]",26,10,31,10,669,76,6.3,69.79,"developmental processes;other biological processes","plasma membrane;other membranes;other cell component","","CLPTM1","ENSG00000104853","","","",989.6,883.6,1013.8,903.8,979.8,1029.2,0.9911425432573469,-0.012835538321170731,0.8814361805790304,0.05480912684251481,0.9339467631918944,0.029677878706670636,7369]
["High","O96006","zinc finger BED domain-containing protein 1 [OS=Homo sapiens]",10,7,11,7,694,78.1,6.1,24.05,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED1","ENSG00000214717","","SUMOylation of chromatin organization proteins","",506.8,483.3,467.1,613.2,618.8,574,0.8068660022148394,-0.30959899262543855,0.003085139261101138,2.510725227428883,0.06067699584553573,1.2169759295333629,397]
["High","O96007","molybdopterin synthase catalytic subunit [OS=Homo sapiens]",23,3,4,3,188,20.9,5.44,8.19,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","MOCS2","ENSG00000164172","","Molybdenum cofactor biosynthesis","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system",275.1,253.7,265.2,253.5,239,276,1.033181522446324,0.04709374745218663,0.5311260434165282,0.27480240271420525,0.7167355940194008,0.14464102736753393,5786]
["High","O96008","Mitochondrial import receptor subunit TOM40 homolog [OS=Homo sapiens]",45,12,98,12,361,37.9,7.25,220.56,"cell organization and biogenesis;transport","other membranes;cytosol;mitochondrion;other cell component","transporter activity","TOMM40","ENSG00000130204","IL-18 signaling pathway","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",2313.8,2511,2561.5,2268.4,2941.6,2735.4,0.9296322400382611,-0.10526799200467671,0.4309764747816691,0.3655464355268553,0.6501283452657017,0.1870008985288639,5176]
["High","O96011-1","Peroxisomal membrane protein 11B [OS=Homo sapiens]",7,2,3,2,259,28.4,9.85,7.3,"cell organization and biogenesis;signal transduction","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PEX11B","ENSG00000131779; ENSPPAG00000024465; ENSPTRG00000001203","","Class I peroxisomal membrane protein import","Peroxisome",185.7,186.1,209.8,224.3,225.4,229.3,0.8565537555228275,-0.22338430521250005,0.01609016707216531,1.7934394463830856,0.13626033025972534,0.8656305627780795,922]
["High","O96013-1","serine/threonine-protein kinase PAK 4 [OS=Homo sapiens]",12,6,13,6,591,64,9.73,26.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","PAK4","ENSG00000130669","Integrin-mediated cell adhesion; Focal adhesion; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle","ErbB signaling pathway; Ras signaling pathway; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Regulation of actin cytoskeleton; Human immunodeficiency virus 1 infection; MicroRNAs in cancer; Renal cell carcinoma",439.5,499.5,386.4,456.8,399.4,449.1,1.0153987589059985,0.022046401814745157,0.8661587331870938,0.06240251141205976,0.9261801408826114,0.033304535367133,7302]
["High","O96017-1","Serine/threonine-protein kinase Chk2 [OS=Homo sapiens]",26,11,24,11,543,60.9,5.91,43.01,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","CHEK2","ENSG00000183765","miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection",676.5,641.1,688.1,900.1,968.6,920.3,0.7191466475439225,-0.4756421015362918,4.5702053671935791E-4,3.3400642839925165,0.0268301981255996,1.5713761203009668,133]
["High","O96018","amyloid-beta A4 precursor protein-binding family A member 3 [OS=Homo sapiens]",3,2,2,2,575,61.4,4.94,2.99,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","APBA3","ENSG00000011132","","Neurexins and neuroligins","",98,72.1,113.7,90.7,101.6,124.8,0.8949858088930938,-0.16006328804328768,0.5199443997819863,0.2840430951323197,0.709122423318384,0.14927878148560986,5725]
["High","O96019-1","Actin-like protein 6A [OS=Homo sapiens]",47,18,54,18,429,47.4,5.6,115.33,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","ACTL6A","ENSCANG00000034249; ENSCATG00000017467; ENSCCAG00000029449; ENSCJAG00000013036; ENSCSAG00000013017; ENSG00000136518; ENSGGOG00000015710; ENSMFAG00000030153; ENSMMUG00000009742; ENSPANG00000024431; ENSPPAG00000031814; ENSPTRG00000023973; ENSRBIG00000036584; ENSRROG00000035215","Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; UCH proteinases; HATs acetylate histones; DNA Damage Recognition in GG-NER","Thermogenesis; Hepatocellular carcinoma",3219.2,2919.6,3150.8,3284.3,3099.5,3214.4,0.9678481381925776,-0.047147398073370865,0.38452277942873636,0.41507792715731895,0.6147325679319356,0.21131377777152838,4884]
["High","O96028-1","Histone-lysine N-methyltransferase NSD2 [OS=Homo sapiens]",17,19,38,19,1365,152.2,8.69,80.41,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD2","ENSG00000109685","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Lysine degradation; Metabolic pathways; Transcriptional misregulation in cancer",1544.1,1695.9,1488.7,1828.4,1795.9,1872.4,0.860279804246184,-0.2171221251371701,0.017665213346679923,1.752881113127165,0.14278466440049362,0.845318434884023,966]
["High","P00167-1","Cytochrome b5 [OS=Homo sapiens]",39,4,9,4,134,15.3,4.96,29.2,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","CYB5A","ENSG00000166347; ENSPTRG00000010111","Oxidation by cytochrome P450","Vitamin C (ascorbate) metabolism","",282.7,366.4,347.4,387.6,324.3,333.1,0.9535885167464114,-0.06856123212918717,0.641512564994626,0.192794832890939,0.7899274731868853,0.1024127814192651,6341]
["High","P00338-1","L-lactate dehydrogenase A chain [OS=Homo sapiens]",72,24,204,21,332,36.7,8.27,395.17,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HEL-S-133P; LDHA","ENSG00000134333; ENSG00000288299","Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glycolysis and gluconeogenesis","Pyruvate metabolism","Glycolysis / Gluconeogenesis; Cysteine and methionine metabolism; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer",6199,4564.5,6527.5,6096.8,6986.4,6686,0.8746433846589645,-0.19323318314789364,0.279454498828219,0.5536888944555065,0.5262857517729701,0.27877838755471307,4146]
["High","P00367","Glutamate dehydrogenase 1, mitochondrial [OS=Homo sapiens]",48,24,107,10,558,61.4,7.8,248.82,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","GLUD1","ENSG00000148672","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension","Transcriptional activation of mitochondrial biogenesis; Glutamate and glutamine metabolism","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Nitrogen metabolism; Metabolic pathways; Carbon metabolism; Necroptosis; Proximal tubule bicarbonate reclamation",4224.3,4757.3,4398.7,4488.7,4522.5,4612.7,0.9821196573668332,-0.02602928768639152,0.640938774229322,0.19318345454408867,0.7900931400667108,0.1023217089213464,6334]
["High","P00374","dihydrofolate reductase [OS=Homo sapiens]",38,6,19,6,187,21.4,7.42,30.46,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;mitochondrion","nucleic acid binding activity;other molecular function","DHFR","ENSG00000228716","Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Ethanol effects on histone modifications; Nucleotide metabolism","G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","One carbon pool by folate; Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance",573.8,564.9,567.9,640.1,602.8,606.7,0.9226859861591694,-0.11608834982286288,0.01707189422785469,1.767718288664764,0.14046085366816588,0.8524446964334214,949]
["High","P00387","NADH-cytochrome b5 reductase 3 [OS=Homo sapiens]",46,13,43,13,301,34.2,7.59,99.19,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CYB5R3","ENSG00000100243","Oxidation by cytochrome P450","Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism","Amino sugar and nucleotide sugar metabolism",1556.5,1077.7,1722.2,1539.7,1684.5,1618.8,0.8995250877555234,-0.15276457608347763,0.4580721070678933,0.33906615248347927,0.6659145432854424,0.17658150020034358,5371]
["High","P00390","Glutathione reductase, mitochondrial [OS=Homo sapiens]",48,18,57,17,522,56.2,8.5,129.23,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","other molecular function","GSR","ENSG00000104687","Glutathione metabolism; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II","","Glutathione metabolism; Metabolic pathways; Thyroid hormone synthesis; Diabetic cardiomyopathy",1890.7,2159.9,1968.1,1934.1,2045.8,2084.6,0.9924478522549264,-0.010936796429980652,0.8760620789840884,0.05746511802715023,0.9302723667493217,0.03138987934025518,7353]
["High","P00403","Cytochrome c oxidase subunit 2 [OS=Homo sapiens]",28,5,19,5,227,25.5,4.82,32.11,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO2","ENSG00000198712","Electron transport chain: OXPHOS system in mitochondria; Endothelin pathways; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly; CCL18 signaling pathway","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",852.4,859.8,876.3,882.4,893.4,906.6,0.9649940351923652,-0.051408070045494414,0.03456944955738519,1.4613075355890197,0.18835887100074217,0.7250139213277288,1433]
["High","P00441","Superoxide dismutase [Cu-Zn] [OS=Homo sapiens]",92,14,102,14,154,15.9,6.13,283.23,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SOD1","ENSG00000142168","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species","Peroxisome; Longevity regulating pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis",4198.9,4378.5,3819.4,3800.6,3553.4,3814.9,1.1099392061886129,0.15048065915906428,0.09183733392770246,1.03698073249503,0.3029429249292357,0.5186391857654773,2367]
["High","P00488","Coagulation factor XIII A chain [OS=Homo sapiens]",7,4,7,4,732,83.2,6.09,10.39,"protein metabolism;other metabolic processes;stress response","non-structural extracellular;other cell component","other molecular function","F13A1","ENSG00000124491","Complement system","Platelet degranulation ; Interleukin-4 and Interleukin-13 signaling; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades; Coronavirus disease",265.8,236.8,231.7,233.4,236,253.1,1.0163321799307958,0.023372012359468168,0.7648844445607668,0.11640417122585342,0.8664177779095411,0.06227264506140478,6893]
["High","P00491","purine nucleoside phosphorylase [OS=Homo sapiens]",83,19,70,19,289,32.1,6.95,202.75,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PNP","ENSG00000198805","VEGFA-VEGFR2 signaling pathway","Neutrophil degranulation; Purine catabolism; Purine salvage","Purine metabolism; Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways",2712.5,2254.3,2869.1,2672.4,3209.9,2899,0.8923394030496624,-0.16433554845908965,0.26184898722988875,0.5819491015078508,0.507450209057079,0.29460656423759324,4029]
["High","P00492","Hypoxanthine-guanine phosphoribosyltransferase [OS=Homo sapiens]",42,6,24,6,218,24.6,6.68,36.92,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HPRT1","ENSG00000165704","Mesodermal commitment pathway; Nucleotide metabolism","Purine salvage","Purine metabolism; Drug metabolism; Metabolic pathways",266.6,250.1,270.1,318.7,290.7,303.5,0.8618687698543105,-0.21445987695722174,0.014479403061264752,1.8392493423199934,0.12891126465490899,0.8897091310273985,877]
["High","P00505","Aspartate aminotransferase, mitochondrial [OS=Homo sapiens]",53,20,119,20,430,47.5,9.01,261.14,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","other molecular function","GOT2","ENSG00000125166","Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis","Glyoxylate metabolism and glycine degradation; Gluconeogenesis; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Cysteine and methionine metabolism; Arginine and proline metabolism; Tyrosine metabolism; Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Fat digestion and absorption",5320.2,4819.5,5419.7,5472.1,5644.8,5794.4,0.9200593685878672,-0.12020113806135153,0.0959115816590038,1.0181289470848276,0.3097095242322174,0.5090454389509453,2418]
["High","P00519-2","Isoform IB of Tyrosine-protein kinase ABL1 [OS=Homo sapiens]",12,9,13,9,1149,124.9,8.84,29.2,"","","","ABL1","","","","",531.8,534.7,464.2,516,521.1,498.5,0.9968090648606409,-4.6109067722084444E-3,0.9490649577482136,0.02270406172849752,0.9717150786910638,0.012461058007513917,7626]
["High","P00533-1","epidermal growth factor receptor [OS=Homo sapiens]",12,9,10,9,1210,134.2,6.68,20.89,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function","EGFR","ENSG00000146648","Androgen receptor signaling pathway; Glioblastoma signaling pathways; AGE/RAGE pathway; Gastric cancer network 2; Spinal cord injury; Aryl hydrocarbon receptor pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Bladder cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; ERK pathway in Huntington's disease; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Extracellular vesicles in the crosstalk of cardiac cells; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Regulatory circuits of the STAT3 signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway","Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF/MAP kinase cascade; Cargo recognition for clathrin-mediated endocytosis; HCMV Early Events; NOTCH3 Activation and Transmission of Signal to the Nucleus; Signaling by ERBB4; SHC1 events in ERBB2 signaling; GRB2 events in ERBB2 signaling; PI3K events in ERBB2 signaling; ERBB2 Regulates Cell Motility; ERBB2 Activates PTK6 Signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Signal transduction by L1; GRB2 events in EGFR signaling; GAB1 signalosome; SHC1 events in EGFR signaling; EGFR downregulation; EGFR interacts with phospholipase C-gamma; Inhibition of Signaling by Overexpressed EGFR; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PLCG1 events in ERBB2 signaling; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; PTK6 promotes HIF1A stabilization; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors; Signaling by ERBB2 ECD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Calcium signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; Endocytosis; PI3K-Akt signaling pathway; Focal adhesion; Adherens junction; Gap junction; JAK-STAT signaling pathway; Regulation of actin cytoskeleton; GnRH signaling pathway; Estrogen signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Epithelial cell signaling in Helicobacter pylori infection; Shigellosis; Hepatitis C; Human cytomegalovirus infection; Human papillomavirus infection; Coronavirus disease; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer",207.1,234.1,249.3,258.4,259.9,286.3,0.8581904051702709,-0.22063032348021697,0.06789024496165924,1.1681926243009373,0.2612553142733541,0.5829348666756479,2029]
["High","P00558","phosphoglycerate kinase 1 [OS=Homo sapiens]",78,30,422,25,417,44.6,8.1,981.27,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol","kinase activity;other molecular function","PGK1","ENSG00000102144","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glycolysis and gluconeogenesis","Gluconeogenesis; Glycolysis; Manipulation of host energy metabolism","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway",20300.9,19941.7,19805.2,19444.8,19104.5,19412.6,1.035987433124173,0.05100650275477841,0.01923402901508351,1.7159297331437613,0.14810581711022885,0.829427883482443,1014]
["High","P00568","Adenylate kinase isoenzyme 1 [OS=Homo sapiens]",48,9,23,9,194,21.6,8.63,54.93,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK1","ENSG00000106992","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors",1266.4,1243.9,1260.2,1275.1,1262,1287.3,0.9859062859533522,-0.020477575277912833,0.14431925547389873,0.8406757202706164,0.3743670254950835,0.42670241120582436,3010]
["High","P00734","Prothrombin [OS=Homo sapiens]",5,2,5,2,622,70,5.9,5.85,"protein metabolism;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","F2","ENSG00000180210","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; IL1 and megakaryocytes in obesity; Regulation of actin cytoskeleton; Complement and coagulation cascades","Cell surface interactions at the vascular wall; Regulation of Complement cascade; G alpha (q) signalling events; Peptide ligand-binding receptors; Thrombin signalling through proteinase activated receptors (PARs); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Defective F8 cleavage by thrombin; Gamma-carboxylation of protein precursors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Platelet Aggregation (Plug Formation); Defective factor XII causes hereditary angioedema","Phospholipase D signaling pathway; Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Platelet activation; Regulation of actin cytoskeleton; Pathogenic Escherichia coli infection; Coronavirus disease; Pathways in cancer",85.7,73.3,88.3,64.7,62.4,62.2,1.306391970417327,0.3855878286862327,0.01465817859398789,1.8339199912040514,0.12991039552991765,0.8863560949574637,881]
["High","P00747","Plasminogen [OS=Homo sapiens]",5,4,13,4,810,90.5,7.24,18.2,"cell organization and biogenesis;protein metabolism;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLG","ENSG00000122194","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; Complement system; Fibrin complement receptor 3 signaling pathway; Complement and coagulation cascades","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by PDGF; Platelet degranulation ; Activation of Matrix Metalloproteinases; Dissolution of Fibrin Clot","Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Staphylococcus aureus infection; Influenza A",693.4,396.7,699.7,611,672.5,643.3,{"$f":"AVERAGE(T962:V962)/AVERAGE(W962:Y962)","v":0.928897654141582},{"$f":"LOG(Z962,2)","v":-0.1064084455306085},{"$f":"TTEST(T962:V962,W962:Y962,2,2)","v":0.676169055305094},{"$f":"-LOG10(AB962)","v":0.16994470848559412},{"$f":"AB962*7808/AF962","v":0.8131107321457222},{"$f":"-LOG10(AD962)","v":0.08985030669971467},6493]
["High","P00750-1","Tissue-type plasminogen activator [OS=Homo sapiens]",5,2,2,2,562,62.9,7.8,5.04,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;other molecular function","PLAT","ENSG00000104368","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; NOTCH1 regulation of endothelial cell calcification; Fibrin complement receptor 3 signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Complement and coagulation cascades","Signaling by PDGF; Dissolution of Fibrin Clot","Apelin signaling pathway; Complement and coagulation cascades; Transcriptional misregulation in cancer; Prostate cancer; Fluid shear stress and atherosclerosis",70.3,79.7,78,72.1,62.5,67.9,1.125925925925926,0.1711119163927547,0.10140055518973512,0.993959667140964,0.31720173674737656,0.49866444349271494,2496]
["High","P00813","adenosine deaminase [OS=Homo sapiens]",25,6,9,6,363,40.7,5.95,14.19,"cell adhesion;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ADA","ENSG00000196839","","Purine salvage","Purine metabolism; Metabolic pathways; Primary immunodeficiency",431.5,322.9,441.2,430.3,445,414,0.9273249049872023,-0.10885319326561686,0.46768913280096697,0.33004272121701467,0.672631561781166,0.17222275821405908,5429]
["High","P00846","ATP synthase subunit A [OS=Homo sapiens]",4,1,5,1,226,24.8,10.1,12.85,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ATP6","ENSG00000198899","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",282.3,225.8,317.2,262,308.2,326.8,0.9200668896321069,-0.12018934476925697,0.5073892268334004,0.29465875819524423,0.7006889075194889,0.1544747576901096,5654]
["High","P00918","Carbonic anhydrase 2 [OS=Homo sapiens]",13,3,4,3,260,29.2,7.4,8.46,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CA2","ENSG00000104267","Proximal tubule transport","Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Nitrogen metabolism; Metabolic pathways; Proximal tubule bicarbonate reclamation; Collecting duct acid secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion",193.8,187.7,205.3,173.1,164.2,169.9,1.1569400630914828,0.21031412553398282,0.01009712717791423,1.9958021735690936,0.11026345315406197,0.9575684107115388,715]
["High","P00966","Argininosuccinate synthase [OS=Homo sapiens]",19,8,18,8,412,46.5,8.02,33.05,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASS1","ENSG00000130707","Alanine and aspartate metabolism; Amino acid metabolism","Urea cycle","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids; Fluid shear stress and atherosclerosis",952.2,732.7,949.5,883.6,910.6,900.2,0.9777315914489311,-0.03248962647104861,0.7980596286327442,0.09796465824990992,0.8875159635898684,0.051823826625949504,7021]
["High","P01023","alpha-2-macroglobulin [OS=Homo sapiens]",5,8,58,8,1474,163.2,6.46,101.45,"other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","A2M","ENSG00000175899","Complement system; Complement and coagulation cascades","Degradation of the extracellular matrix; Platelet degranulation ; HDL assembly; Intrinsic Pathway of Fibrin Clot Formation","Complement and coagulation cascades",2583.2,1860,2008.6,1617.2,1657.5,2054,1.2107643515303919,0.2759181037109721,0.2245831168986082,0.6486228950619454,0.4683613719936786,0.3294189304693776,3744]
["High","P01024","Complement C3 [OS=Homo sapiens]",1,2,4,2,1663,187,6.4,5.7,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","C3","ENSG00000125730","Allograft rejection; Complement system; TYROBP causal network in microglia; Cells and molecules involved in local acute inflammatory response ; 16p11.2 distal deletion syndrome; Complement system in neuronal development and plasticity; Acquired partial lipodystrophy / Barraquer-Simons syndrome; Complement activation; Complement and coagulation cascades","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; G alpha (i) signalling events; Neutrophil degranulation; Peptide ligand-binding receptors; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Purinergic signaling in leishmaniasis infection; Alternative complement activation; Activation of C3 and C5","Neuroactive ligand-receptor interaction; Phagosome; Complement and coagulation cascades; Neutrophil extracellular trap formation; Alcoholic liver disease; Shigellosis; Pertussis; Legionellosis; Leishmaniasis; Chagas disease; Staphylococcus aureus infection; Tuberculosis; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Coronavirus disease; Viral carcinogenesis; Systemic lupus erythematosus",75.7,37.8,68.5,36.4,48,56.1,1.2953736654804269,0.37336831997777,0.3456304642551158,0.46138798530540914,0.5845099988962409,0.23320805519791488,4617]
["High","P01033","Metalloproteinase inhibitor 1 [OS=Homo sapiens]",10,2,2,2,207,23.2,8.1,4.81,"stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","TIMP1","ENSG00000102265","Matrix metalloproteinases; Mammary gland development pathway - Puberty (Stage 2 of 4); IL1 and megakaryocytes in obesity; Lung fibrosis; IL-6 signaling pathway; IL-18 signaling pathway; Burn wound healing; CCL18 signaling pathway","Interleukin-4 and Interleukin-13 signaling; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-10 signaling; Activation of Matrix Metalloproteinases","HIF-1 signaling pathway",112.4,108.1,142.1,117.3,126.9,114.7,1.0103092783505156,0.0147970019280808,0.9184485531097459,0.036945165679687364,0.9552745840789791,0.019871776887437537,7507]
["High","P01034","Cystatin-C [OS=Homo sapiens]",12,1,1,1,146,15.8,8.75,0,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CST3","ENSG00000101439","","Neutrophil degranulation; Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Salivary secretion",28.8,34.4,44.1,33,36.3,23.5,1.1562500000000002,0.20945336562895006,0.4579819986419799,0.3391515919614085,0.6660315599546618,0.17650519126601089,5369]
["High","P01111","GTPase NRas [OS=Homo sapiens]",69,10,37,3,189,21.2,5.17,55.68,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","NRAS","ENSG00000213281","Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling","Neutrophil degranulation; FCERI mediated MAPK activation; Regulation of RAS by GAPs; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",1096.9,1079.3,1286.7,1239.3,1346.8,1281.1,0.8954540752999587,-0.15930865154935517,0.140226583118349,0.8531696482292526,0.36914671644911295,0.43280099026298047,2966]
["High","P01112","GTPase HRas [OS=Homo sapiens]",55,8,36,1,189,21.3,5.31,57.96,"stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","HRAS","ENSG00000174775; ENSG00000276536","Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; Pathways affected in adenoid cystic carcinoma; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; IL-2 signaling pathway; Malignant pleural mesothelioma; Alzheimer's disease; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling","Regulation of RAS by GAPs; EPHB-mediated forward signaling; FCERI mediated MAPK activation; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Focal adhesion; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Salmonella infection; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",65.1,60.3,95.1,70.2,66.2,48.9,1.1899622234214786,0.2509157744176171,0.40782270287293115,0.3895286013680944,0.633561413456396,0.1982112809660162,5026]
["High","P01116-2","Isoform 2B of GTPase KRas [OS=Homo sapiens]",62,9,38,3,188,21.4,8.12,58.59,"","","","KRAS","","","","",429.6,496.2,427.3,524.9,520,465.6,0.8957960940086064,-0.1587577193464634,0.15017304387148236,0.82340801638979,0.3809457851034874,0.4191368272266145,3078]
["High","P01130","Low-density lipoprotein receptor [OS=Homo sapiens]",10,8,10,8,860,95.3,5.05,17.03,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LDLR","ENSG00000130164","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M signaling pathway; PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Lipid particles composition; Wnt signaling pathway and pluripotency; Statin inhibition of cholesterol production; Bile acids synthesis and enterohepatic circulation ; Metabolic pathway of LDL, HDL and TG, including diseases; Orexin receptor pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; DNA damage response (only ATM dependent)","Cargo recognition for clathrin-mediated endocytosis; Retinoid metabolism and transport; LDL clearance; Chylomicron clearance","Endocytosis; Ovarian steroidogenesis; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Cushing syndrome; Bile secretion; Cholesterol metabolism; Toxoplasmosis; Hepatitis C; Lipid and atherosclerosis",402.9,379.1,443,666.7,667.6,713.6,0.5981737389520972,-0.7413635202963913,3.4746763192611274E-4,3.4590856455504313,0.025594596887538568,1.5918517061565662,106]
["Medium","P01350","Gastrin [OS=Homo sapiens]",16,1,1,1,101,11.4,5.19,0,"signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","GAST","ENSG00000184502","Gastrin signaling pathway","Gastrin-CREB signalling pathway via PKC and MAPK","Gastric acid secretion",20.9,12.6,25.7,19.7,17.9,19.8,1.0313588850174218,0.04454643895326224,0.8844725061020076,0.05331566262284721,0.9358939324629998,0.028773368309162987,7379]
["Low","P01563","Interferon alpha-2 [OS=Homo sapiens]",10,1,1,1,188,21.5,6.76,0,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","IFNA2","ENSG00000188379","PI3K-Akt signaling pathway; Overview of interferons-mediated signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; SARS coronavirus and innate immunity; Overview of proinflammatory and profibrotic mediators; Type II interferon signaling (IFNG); Toll-like receptor signaling pathway","Factors involved in megakaryocyte development and platelet production; Regulation of IFNA signaling; TRAF6 mediated IRF7 activation","Cytokine-cytokine receptor interaction; PI3K-Akt signaling pathway; Necroptosis; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Alcoholic liver disease; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Autoimmune thyroid disease; Lipid and atherosclerosis",78.9,134.8,44.4,65.2,35.5,56.5,1.6418575063613234,0.7153289238353637,0.29257519262558307,0.5337625003657207,0.5370068415657152,0.2700201812737955,4254]
["High","P01834","immunoglobulin kappa constant [OS=Homo sapiens]",19,1,1,1,107,11.8,6.52,2.75,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGKC","","","FCERI mediated NF-kB activation; Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers","",14.6,11,18.7,20.9,10,15.3,0.9588744588744588,-0.0605861528610394,0.877430947852088,0.05678705166761768,0.9312193612653396,0.03094800305148132,7357]
["Medium","P01854","immunoglobulin heavy constant epsilon [OS=Homo sapiens]",4,1,1,1,428,47,8.06,0,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHE","ENSG00000211891; ENSG00000276192","","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; Interleukin-4 and Interleukin-13 signaling","",42.8,39.6,41.8,44.1,40.9,46.7,0.9430523917995444,-0.08459017203603304,0.2639122889412959,0.5785403866077884,0.5092998398550762,0.2930264603839389,4046]
["High","P02042","Hemoglobin subunit delta [OS=Homo sapiens]",13,2,12,2,147,16,8.05,25.21,"other metabolic processes;transport;other biological processes","cytosol;other cell component","other molecular function","HBD","ENSG00000223609","VEGFA-VEGFR2 signaling pathway","Factors involved in megakaryocyte development and platelet production","",470.8,405.8,457.4,306.1,312.5,383,1.3318690095846646,0.41345219913932907,0.024792967119824403,1.6056714955534201,0.16322385098784903,0.7872163799230285,1186]
["High","P02452","Collagen alpha-1(I) chain [OS=Homo sapiens]",9,11,16,11,1464,138.9,5.8,18.87,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi;other cell component","extracellular structural activity;other molecular function","COL1A1","ENSG00000108821","Focal adhesion; Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miR-509-3p alteration of YAP1/ECM axis; PI3K-Akt signaling pathway; Inflammatory response pathway; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Angiotensin II receptor type 1 pathway; Burn wound healing; CCL18 signaling pathway; NRP1-triggered signaling pathways in pancreatic cancer","GPVI-mediated activation cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Collagen degradation; Integrin cell surface interactions; ECM proteoglycans; Collagen chain trimerization; Syndecan interactions; MET activates PTK2 signaling; RUNX2 regulates osteoblast differentiation; Anchoring fibril formation; Crosslinking of collagen fibrils; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); Scavenging by Class A Receptors; GP1b-IX-V activation signalling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Platelet activation; Relaxin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Protein digestion and absorption; Amoebiasis; Human papillomavirus infection; Proteoglycans in cancer; Diabetic cardiomyopathy",622.9,368.2,353.6,282.2,258.2,439,1.372983459260772,0.45731424501436524,0.30748757997295845,0.5121724215410648,0.5509093676982239,0.2589198427926663,4358]
["High","P02458-1","Isoform 1 of Collagen alpha-1(II) chain [OS=Homo sapiens]",3,4,4,4,1418,134.3,8.56,4.78,"","","","COL2A1","","","","",220.3,106.1,104.8,99.2,55.2,112.1,1.6180112570356473,0.6942216451059673,0.2610606450302637,0.5832585932648096,0.5068029628036547,0.2951608548668973,4022]
["High","P02462","Collagen alpha-1(IV) chain [OS=Homo sapiens]",2,3,6,3,1669,160.5,8.28,20.23,"","","","","","","","",136.7,150.1,142.6,123.4,129.2,146.8,1.0751126690035053,0.10448785841480074,0.28114333470538105,0.55107220820646,0.5276844128316382,0.2776257341745673,4160]
["High","P02533","Keratin, type I cytoskeletal 14 [OS=Homo sapiens]",39,20,65,5,472,51.5,5.16,146.33,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KRT14","ENSG00000186847","Corticotropin-releasing hormone signaling pathway","Formation of the cornified envelope; Type I hemidesmosome assembly","Estrogen signaling pathway; Staphylococcus aureus infection",1493.8,1253.3,1335.9,1423.9,1319.6,1787.3,0.901165357111327,-0.15013624079508575,0.3992071020367708,0.3988017410621625,0.6265344829553983,0.20305502148527135,4975]
["High","P02538","Keratin, type II cytoskeletal 6A [OS=Homo sapiens]",34,21,119,2,564,60,8,216.7,"cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6A","ENSG00000205420","Ectoderm differentiation; Ectoderm differentiation","Formation of the cornified envelope","",746.8,545.4,488.7,506,488.1,854.8,0.9632213748715451,-0.05406068754990282,0.8815396322920197,0.05475815789805369,0.9339296402898357,0.0296858410984698,7370]
["High","P02545","Prelamin-A/C [OS=Homo sapiens]",65,49,228,46,664,74.1,7.02,519.2,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LMNA","ENSG00000160789","Arrhythmogenic right ventricular cardiomyopathy; Adipogenesis; Fas ligand pathway and stress induction of heat shock proteins; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome","XBP1(S) activates chaperone genes; Signaling by BRAF and RAF1 fusions","Apoptosis; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy",10844.5,13044.4,10424.9,6639,6383.9,6641.5,1.7449706067817987,0.8032027351127025,0.003934208222117864,2.4051426583150777,0.0663462155470762,1.1781838446743953,463]
["High","P02647","Apolipoprotein A-I [OS=Homo sapiens]",8,2,10,1,267,30.8,5.76,21.78,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","APOA1","ENSG00000118137","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5","PPARA activates gene expression; Platelet degranulation ; Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging of heme from plasma; Scavenging by Class B Receptors; Heme signaling; Retinoid metabolism and transport; HDL clearance; Defective ABCA1 causes TGD; HDL assembly; Scavenging by Class A Receptors; ABC transporters in lipid homeostasis; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","PPAR signaling pathway; Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; African trypanosomiasis; Lipid and atherosclerosis",226.7,53.9,218.5,86.1,92.6,104.5,1.7623587570621468,0.8175076384184948,0.2720249339310943,0.565391286508482,0.5181680127187079,0.2855294001663484,4099]
["High","P02649","Apolipoprotein E [OS=Homo sapiens]",64,18,94,18,317,36.1,5.73,206.13,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","APOE","ENSG00000130203","Vitamin B12 metabolism; Alzheimer's disease and miRNA effects; Apoptosis-related network due to altered Notch3 in ovarian cancer; ApoE and miR-146 in inflammation and atherosclerosis; Statin inhibition of cholesterol production; Familial hyperlipidemia type 3; Alzheimer's disease","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Retinoid metabolism and transport; Nuclear signaling by ERBB4; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors","Cholesterol metabolism; Alzheimer disease",3671.7,4379.7,3731.1,3357.4,3328.3,3418.9,1.1660530847336856,0.2216334689318359,0.0704703550208139,1.151993540576067,0.2660698897497655,0.5750042703393365,2068]
["High","P02671-1","Fibrinogen alpha chain [OS=Homo sapiens]",2,3,10,3,866,94.9,6.01,16.25,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGA","ENSG00000171560","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway","Regulation of TLR by endogenous ligand; Platelet degranulation ; Integrin cell surface interactions; Amyloid fiber formation; ER-Phagosome pathway; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease",346,157,178.9,154.5,125.1,251,1.2851488880512625,0.3619355093103079,0.5154340014025967,0.2878269359316751,0.7066740444164135,0.15078085968815885,5695]
["High","P02675","Fibrinogen beta chain [OS=Homo sapiens]",11,7,61,7,491,55.9,8.27,96.62,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGB","ENSG00000171564","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway; Complement and coagulation cascades","Platelet degranulation ; Common Pathway of Fibrin Clot Formation; ER-Phagosome pathway; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease",1559.3,832.5,810.7,754.9,658,1084,1.2825904121110177,0.35906052759195517,0.4447451812722025,0.3518887487150423,0.6560684631349627,0.18305083804767472,5293]
["High","P02679","Fibrinogen gamma chain [OS=Homo sapiens]",7,3,26,3,453,51.5,5.62,46.62,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGG","ENSG00000171557","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway","ER-Phagosome pathway; Platelet degranulation ; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Staphylococcus aureus infection; Coronavirus disease",596.2,379,374.9,347.7,368.9,457.6,1.149804121955374,0.20138810781910527,0.5065987951617897,0.29533584742191876,0.699844903153442,0.15499819593980435,5652]
["High","P02748","complement component C9 [OS=Homo sapiens]",4,2,4,2,559,63.1,5.59,2.69,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes","","C9","ENSG00000113600","Allograft rejection; Complement system; Complement system in neuronal development and plasticity; Complement activation; Complement and coagulation cascades","Regulation of Complement cascade; Terminal pathway of complement","Complement and coagulation cascades; Prion disease; Amoebiasis; Coronavirus disease; Systemic lupus erythematosus",149.2,94.7,120.5,90.6,102.4,93.5,1.2719022687609074,0.3469878201577834,0.18284040119861358,0.7379278344284689,0.42187288787197835,0.3748183841368195,3384]
["Medium","P02749","Beta-2-glycoprotein 1 [OS=Homo sapiens]",3,1,1,1,345,38.3,7.97,1.61,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;other cell component","enzyme regulator activity;other molecular function","APOH","ENSG00000091583","","Platelet degranulation","Cholesterol metabolism",82.9,73.6,73.3,45.4,39.5,51,1.6909492273730684,0.7578333418787221,2.393101962069078E-3,2.621038797157308,0.053693506091480915,1.2700782364452536,348]
["High","P02751","fibronectin [OS=Homo sapiens]",30,55,452,55,2386,262.5,5.71,976.91,"","","","","","","","",11357.9,8164.8,7477.8,6481.7,6159.6,9166.5,1.238112051651244,0.3081418872874266,0.3208545525541307,0.4936917941938575,0.5629735609758769,0.24951200051615374,4450]
["Medium","P02753","Retinol-binding protein 4 [OS=Homo sapiens]",4,1,1,1,201,23,6.07,1.6,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other cell component","transporter activity;other molecular function","RBP4","ENSG00000138207","Sterol regulatory element-binding proteins (SREBP) signaling; Vitamin A and carotenoid metabolism","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events; Retinoid metabolism disease events","",51.8,39.5,62.4,48.5,41.8,34.8,1.228617106314948,0.2970353755249515,0.2838485703614944,0.5469132888110456,0.5302128319097006,0.2755497659274454,4180]
["Medium","P02760","Protein AMBP [OS=Homo sapiens]",2,1,3,1,352,39,6.25,0,"cell adhesion;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","AMBP","ENSG00000106927","","Scavenging of heme from plasma","",157.5,80.5,179.8,104.8,102.7,104.9,1.3373879641485278,0.4194180389251292,0.30780009913636097,0.5117312446268026,0.5509635887337705,0.2588771012108486,4362]
["High","P02765","Alpha-2-HS-glycoprotein [OS=Homo sapiens]",7,4,33,4,367,39.3,5.72,45.09,"","","","","","","","",2113.7,2270.4,2182.8,1270.7,1377.5,1374,1.6326637163741236,0.7072276661719965,1.2120432846303562E-4,3.916481870317878,0.015772723277323035,1.8020933160428863,60]
["High","P02768-1","Serum albumin [OS=Homo sapiens]",8,6,55,6,609,69.3,6.28,93.09,"stress response;other biological processes","non-structural extracellular;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","ALB","ENSG00000163631","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; VEGFA-VEGFR2 signaling pathway","Cytoprotection by HMOX1; Scavenging of heme from plasma; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Recycling of bile acids and salts; Heme degradation; HDL remodeling; Heme biosynthesis","Thyroid hormone synthesis",3092.1,3182.5,3072.8,2162.9,2159.5,2182.2,1.4370445530855092,0.5231047907577538,1.0501693072563013E-5,4.978740678758932,0.007454292682779273,2.127593559258522,11]
["High","P02771","Alpha-fetoprotein [OS=Homo sapiens]",3,2,3,2,609,68.6,5.68,8.34,"other metabolic processes;developmental processes;signal transduction","non-structural extracellular;ER/Golgi;other cell component","other molecular function","AFP","ENSG00000081051","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Hippo signaling pathway",171,163.6,187.7,110.5,131.4,122.1,1.43489010989011,0.5209402532861986,0.004846946911624037,2.3145317370577234,0.07449795568102457,1.127855644683007,508]
["High","P02774","vitamin D-binding protein [OS=Homo sapiens]",10,4,11,4,474,52.9,5.54,34.45,"transport","non-structural extracellular","transporter activity;cytoskeletal activity;other molecular function","HEL-S-51","","","","",349.8,355.2,340.5,242.8,250.6,256.7,1.3938141581122518,0.4790382146903671,7.467237815206937E-5,4.126840017121267,0.011898814869619544,1.9244962924911448,49]
["High","P02792","Ferritin light chain [OS=Homo sapiens]",40,6,15,6,175,20,5.78,39.57,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTL","ENSG00000087086","Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Ferroptosis; Necroptosis; Mineral absorption",740.9,979.3,831.5,377.4,411.5,408.8,2.1305001252400433,1.0911921363240102,3.0310344663438482E-3,2.5184091251771354,0.06021963642038872,1.2202618708939268,393]
["High","P03905","NADH-ubiquinone oxidoreductase chain 4 [OS=Homo sapiens]",6,2,2,2,459,51.5,9.35,2.5,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-ND4","ENSG00000198886","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",73.5,46.9,86.3,90.2,113.9,101.8,0.6757110166721149,-0.5655217181327554,0.07009313509639654,1.1543245146402927,0.2651585265662133,0.576494402936831,2064]
["High","P04062","glucosylceramidase [OS=Homo sapiens]",6,3,3,3,536,59.7,7.61,8.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GBA","ENSG00000177628","Sphingolipid pathway","Glycosphingolipid metabolism; Association of TriC/CCT with target proteins during biosynthesis","Other glycan degradation; Sphingolipid metabolism; Metabolic pathways; Lysosome",176.3,195.3,202,169.7,186,196.1,1.0395070677781808,0.0558995673486322,0.5407909258873612,0.26697060417830903,0.721917515699866,0.14151242088299593,5849]
["Medium","P04150","Glucocorticoid receptor [OS=Homo sapiens]",1,1,1,1,777,85.6,6.38,2.62,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","NR3C1","ENSG00000113580","Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling","Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression","Neuroactive ligand-receptor interaction",41,32.8,34.3,45.1,41.8,43.6,0.8283524904214559,-0.27168328372259676,0.050315950238308774,1.298294321059074,0.22630584070317677,0.6453042372409117,1736]
["Medium","P04437","T-cell receptor alpha chain V region CTL-L17 [OS=Homo sapiens]",5,1,1,1,139,15.4,8.43,2.06,"","","","","","","","",79.2,40.9,90.4,85.5,96.3,69.5,0.8376442499005173,-0.255590437926897,0.4657787976851463,0.331820284495879,0.6718641884954041,0.17271850692830498,5413]
["High","P04733","Metallothionein-1F [OS=Homo sapiens]",33,2,13,1,61,6.1,7.83,22.3,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1F","ENSG00000198417","Copper homeostasis; Zinc homeostasis","Metallothioneins bind metals","Mineral absorption",702.4,908.5,697.2,628.3,656.6,661.2,1.1860130517445149,0.24611988642985122,0.16139776135789324,0.7921024933850541,0.3972867971886603,0.40089586737198496,3172]
["High","P04920-1","Anion exchange protein 2 [OS=Homo sapiens]",8,5,9,5,1241,136.9,6.29,19.31,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC4A2","ENSG00000164889","Proximal tubule transport","Bicarbonate transporters","Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion",122.9,131.8,119.9,131,112.3,143.3,0.9689601655457838,-0.04549073796819028,0.7010608286207785,0.15424429816995514,0.8292505605015965,0.08131422626290491,6601]
["High","P05067-8","Isoform APP751 of Amyloid-beta A4 protein [OS=Homo sapiens]",40,20,50,1,751,84.8,4.79,114.1,"","","","APP","","","","",20.9,17.7,21.5,23.1,22.9,22.4,0.8786549707602338,-0.18663133417471262,0.08203085401071132,1.0860227670518723,0.28593611969447946,0.5437309807273998,2240]
["High","P05141","ADP/ATP translocase 2 [OS=Homo sapiens]",51,18,174,5,298,32.8,9.69,350.99,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","transporter activity;other molecular function","SLC25A5","ENSG00000005022","Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization","Calcium signaling pathway; cGMP-PKG signaling pathway; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Influenza A; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy",9425.2,8400.7,9730.5,8418.5,10021.8,9584,0.9833037756518451,-0.024290912376922245,0.8152362315798425,0.08871652720387302,0.8969091864415119,0.04725152777412456,7097]
["High","P05387","60S acidic ribosomal protein P2 [OS=Homo sapiens]",70,5,26,5,115,11.7,4.54,87.36,"protein metabolism;other metabolic processes","cytosol;translational apparatus","other molecular function","RPLP2","ENSG00000177600","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",648.6,966.2,896.2,990.4,747.2,608.9,1.0701044108246325,0.09775156824323686,0.728696805711891,0.13745313422810934,0.8449160467773158,0.07318644162154375,6734]
["High","P05423","DNA-directed RNA polymerase III subunit RPC4 [OS=Homo sapiens]",29,9,25,9,398,44.4,6.98,52.77,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3D","ENSG00000168495","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",1038.1,977.9,1172.8,1237.3,1295.4,1232.7,0.8468688585542042,-0.23978951583964025,0.03456810545211373,1.4613244218530042,0.188483077772419,0.7247276351662055,1432]
["High","P05937","Calbindin [OS=Homo sapiens]",15,2,4,2,261,30,4.83,6.53,"developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CALB1","ENSG00000104327","","Amyloid fiber formation","Endocrine and other factor-regulated calcium reabsorption",89.9,94.1,98.1,84.9,78.4,79.4,1.1623403378656778,0.21703255743443775,0.013482795718731778,1.8702200455360005,0.12473183527471293,0.9040226875030202,844]
["High","P06280","alpha-galactosidase A [OS=Homo sapiens]",25,8,30,8,429,48.7,5.6,70.75,"other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","GLA","ENSG00000102393","Degradation pathway of sphingolipids, including diseases; Ciliary landscape","Neutrophil degranulation; Glycosphingolipid metabolism","Galactose metabolism; Glycerolipid metabolism; Sphingolipid metabolism; Glycosphingolipid biosynthesis; Metabolic pathways; Lysosome",989.1,918.1,1025.8,982.8,958.3,966.8,1.0086316585852335,0.012399413936642246,0.8090697187471567,0.09201405297046254,0.892892772293682,0.049200692508154946,7075]
["High","P06733-1","alpha-enolase [OS=Homo sapiens]",81,35,836,30,434,47.1,7.39,1693.12,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","ENO1; HEL-S-17; LOC117800423","ENSAMEG00000029491; ENSG00000074800; ENSGGOG00000010357; ENSPPAG00000003541; ENSPPYG00000001920; ENSPTRG00000000109","Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis","Gluconeogenesis; Glycolysis; Manipulation of host energy metabolism","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway",30945.7,35786.3,30765.3,29514.5,29461,29842.7,1.0977175849093994,0.13450693297875335,0.15417044339021402,0.8119988785736535,0.3855742543212015,0.41389197264141675,3122]
["High","P06748","Nucleophosmin [OS=Homo sapiens]",63,19,563,19,294,32.6,4.78,1527.79,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","cytosol;cytoskeleton;translational apparatus;nucleus;other cell component","enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function","NPM1","ENSG00000181163","","TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Nuclear events stimulated by ALK signaling in cancer; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation","",17174.7,21379.1,17857.1,18037,16185.3,16103.7,1.1209096689583915,0.1646700199839305,0.23378558233967456,0.6311822754812462,0.4798627305226548,0.31888297908798713,3804]
["High","P07093-1","Glia-derived nexin [OS=Homo sapiens]",14,4,10,4,398,44,9.29,19.88,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SERPINE2","ENSG00000135919","","Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Dissolution of Fibrin Clot","",336.1,217.5,360.9,247.7,237.6,267.6,1.2146367379466063,0.28052491076680863,0.29848400022439886,0.5250789435982196,0.5418653972918174,0.26610858149367594,4301]
["High","P07355","Annexin A2 [OS=Homo sapiens]",69,30,235,30,339,38.6,7.75,501.76,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","ANXA2","ENSG00000182718","Gastrin signaling pathway; CCL18 signaling pathway; Prostaglandin synthesis and regulation","Smooth Muscle Contraction; Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Dissolution of Fibrin Clot","Salmonella infection",9423.1,12216.6,9693.4,8459.8,9124.8,8751.9,1.189721489188009,0.2506238817731087,0.14122622456011144,0.8500846508462397,0.37090291334186015,0.43073975539254206,2973]
["High","P07384","Calpain-1 catalytic subunit [OS=Homo sapiens]",54,34,124,33,714,81.8,5.67,250.54,"protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","CAPN1","ENSG00000014216","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease","Degradation of the extracellular matrix; Neutrophil degranulation; Formation of the cornified envelope; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Protein processing in endoplasmic reticulum; Apoptosis; Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis",4834.1,3907.9,4763.2,5104.8,5487,5287.8,0.8504748230434017,-0.23365956706226607,0.06723967343700048,1.1723744044659559,0.2600333681010895,0.5849709187509596,2019]
["High","P07741-1","Adenine phosphoribosyltransferase [OS=Homo sapiens]",83,12,86,12,180,19.6,6.02,171.04,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","APRT","ENSG00000198931; ENSPPAG00000005769; ENSPTRG00000008466","","Neutrophil degranulation; Purine salvage","Purine metabolism; Metabolic pathways",3278.2,3513.1,3332.5,3094.6,3223.5,3149.4,1.0693213625561129,0.09669549056270065,0.052612052221320746,1.2789147574879138,0.23052463734235262,0.6372826525301345,1782]
["High","P07951-1","Tropomyosin beta chain [OS=Homo sapiens]",58,26,115,6,284,32.8,4.7,216.72,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","TPM2","ENSANAG00000037556; ENSCANG00000042880; ENSCATG00000041575; ENSCCAG00000023807; ENSG00000198467; ENSMFAG00000002090; ENSMLEG00000037634; ENSMMUG00000016321; ENSMNEG00000031621; ENSNLEG00000004274; ENSPANG00000025431; ENSPPAG00000030835; ENSPTRG00000024321; ENSRBIG00000029128; ENSRROG00000041510; ENSSBOG00000021703","Striated muscle contraction pathway","Striated Muscle Contraction; Smooth Muscle Contraction","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Hypertrophic cardiomyopathy; Dilated cardiomyopathy",1014.2,1363,1473.6,1440.2,1306.6,1380.8,0.9329392382982846,-0.10014497250305797,0.5558369701821341,0.25505257052712066,0.7335995711937293,0.1345409311933401,5916]
["High","P08069","Insulin-like growth factor 1 receptor [OS=Homo sapiens]",9,10,16,9,1367,154.7,5.8,22.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;transporter activity;kinase activity;other molecular function","IGF1R","ENSG00000140443","MicroRNAs in cardiomyocyte hypertrophy; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Apoptosis; Focal adhesion; MECP2 and associated Rett syndrome; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Ebola virus infection in host; Ras signaling; Breast cancer pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Head and neck squamous cell carcinoma; Endochondral ossification; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Malignant pleural mesothelioma","Extra-nuclear estrogen signaling; IRS-related events triggered by IGF1R; Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R); SHC-related events triggered by IGF1R","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Oocyte meiosis; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Long-term depression; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Pathways in cancer; Transcriptional misregulation in cancer; Proteoglycans in cancer; Glioma; Prostate cancer; Melanoma; Breast cancer; Hepatocellular carcinoma",384.7,353.2,356.3,396.1,400.3,414.3,0.9037746758073842,-0.14596496230748077,0.027371237170928608,1.5627055721783136,0.17152056166180624,0.7656838098428291,1246]
["High","P08195","4F2 cell-surface antigen heavy chain [OS=Homo sapiens]",37,19,75,19,630,68,5.01,176.48,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","transporter activity;nucleic acid binding activity;other molecular function","SLC3A2","ENSG00000168003","mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; Proximal tubule transport; Malignant pleural mesothelioma","Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)","mTOR signaling pathway; Ferroptosis; Protein digestion and absorption",3304.5,2948.2,3396.5,3082.2,3158.6,3177.6,1.024505223817209,0.034927340479924254,0.6113405385589032,0.21371680478489857,0.7698946653335349,0.11356868962451706,6200]
["Medium","P08247","Synaptophysin [OS=Homo sapiens]",5,2,2,2,313,33.8,4.81,2.16,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SYP","ENSG00000102003","Synaptic vesicle pathway","Sensory processing of sound by inner hair cells of the cochlea","",97.9,87.9,93.4,78.9,80.6,77,1.1805496828752644,0.23945875798289484,0.009792444467837344,2.0091088826220873,0.10860711137055964,0.964141737105564,704]
["High","P08473","Neprilysin [OS=Homo sapiens]",11,6,8,6,750,85.5,5.73,9.23,"protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","MME","ENSG00000196549","Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Alzheimer's disease","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","Renin-angiotensin system; Hematopoietic cell lineage; Protein digestion and absorption; Alzheimer disease",142.1,128,147.8,163.9,174.4,152.4,0.8516405135520684,-0.23168351274581833,0.04870027928105948,1.3124685482335126,0.22236946235468563,0.6529248539670309,1710]
["High","P08621-1","U1 small nuclear ribonucleoprotein 70 kDa [OS=Homo sapiens]",50,20,154,20,437,51.5,9.94,380.18,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","SNRNP70; SNRP70","ENSCATG00000016149; ENSG00000104852; ENSGGOG00000008245; ENSMLEG00000030967; ENSPANG00000004068; ENSPPAG00000035067; ENSPTRG00000011277; ENSRROG00000033636","mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway","Spliceosome",7078.9,8579.6,6989.6,6971.2,6801.5,7071.6,1.0865368470037369,0.1197371005092371,0.31333983891447675,0.5039843841774254,0.5557831581654327,0.2550946177361191,4402]
["High","P08962","CD63 antigen [OS=Homo sapiens]",13,4,35,4,238,25.6,7.81,62.36,"cell adhesion;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","","CD63","ENSG00000135404","Extracellular vesicles in the crosstalk of cardiac cells","Neutrophil degranulation; Platelet degranulation","Lysosome; Proteoglycans in cancer",2003.1,2392.2,2321.6,1857.6,1789.7,1866.2,1.2182642604516187,0.28482711016611506,0.030351454155872152,1.5178204967883173,0.1795334500371589,0.7458546233355318,1320]
["High","P09001","39S ribosomal protein L3, mitochondrial [OS=Homo sapiens]",30,7,22,7,348,38.6,9.48,40.19,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL3","ENSG00000114686","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",863,854.1,877.2,930.7,902.5,949.9,0.9321619776508212,-0.10134742750860952,0.014759873950557806,1.8309173513755073,0.13036775543660106,0.8848298117299449,884]
["Medium","P09382","Galectin-1 [OS=Homo sapiens]",6,1,1,1,135,14.7,5.5,2.09,"stress response;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LGALS1","ENSG00000100097","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",64.8,49,53.1,63.4,52.3,39.8,1.0733118971061093,0.10206937434463383,0.6708082955209209,0.1734015753493686,0.8092817013948317,0.09190027929494907,6472]
["High","P09496-2","Isoform Non-brain of Clathrin light chain A [OS=Homo sapiens]",24,5,11,5,218,23.6,4.53,24.57,"","","","CLTA","","","","",421.9,444,466.2,770.5,422.4,359.8,0.8579249050041861,-0.2210767221269173,0.5974800055835731,0.22367662361834473,0.7625243353377801,0.11774629160836919,6118]
["High","P09525","annexin A4 [OS=Homo sapiens]",44,13,29,12,319,35.9,6.13,41.2,"signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","enzyme regulator activity;other molecular function","ANXA4","ENSG00000196975","Prostaglandin synthesis and regulation","","",595.2,454.5,609.7,616.9,647.6,634,0.8740584672109559,-0.19419830768543525,0.18814981528830244,0.7254962037023968,0.42792710683689644,0.3686302024695115,3433]
["High","P09884","DNA polymerase alpha catalytic subunit [OS=Homo sapiens]",26,30,71,30,1462,165.8,5.85,155.47,"cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLA1","ENSG00000101868","Retinoblastoma gene in cancer; Pyrimidine metabolism; Nucleotide metabolism; DNA replication","Defective pyroptosis; Activation of the pre-replicative complex; G1/S-Specific Transcription; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate","DNA replication",3331,3141.5,3333.9,3465,3334.6,3398.4,0.9616003137870169,-0.05649072806153833,0.15231630724798267,0.8172535978544574,0.3835168419839564,0.4162155594331483,3101]
["Medium","P09958","Furin [OS=Homo sapiens]",1,1,1,1,794,86.6,6.47,2.67,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","FURIN","ENSG00000140564","SARS-CoV-2 altering angiogenesis via NRP1","Potential therapeutics for SARS; Formation of the cornified envelope; Amyloid fiber formation; Collagen degradation; Signaling by PDGF; Signaling by NODAL; Pre-NOTCH Processing in Golgi; Uptake and function of anthrax toxins; Attachment and Entry; Assembly of active LPL and LIPC lipase complexes; Activation of Matrix Metalloproteinases; TGF-beta receptor signaling activates SMADs; Removal of aminoterminal propeptides from gamma-carboxylated proteins; NGF processing; Synthesis and processing of ENV and VPU; Elastic fibre formation; CD163 mediating an anti-inflammatory response","",61.2,47.7,66.9,81.9,73.3,73.4,0.7690288713910761,-0.37889033307107417,0.050618813061228486,1.295688042642846,0.22727526876484877,0.6434478199869231,1739]
["High","P0CG38","POTE ankyrin domain family member I [OS=Homo sapiens]",11,10,241,1,1075,121.2,6.21,501.86,"","","","POTEI","ENSG00000196834","","","",936.5,1039.3,979.2,780.5,753.4,819.7,1.2555234534330386,0.3282889786974269,0.004837712429077989,2.3153599512235146,0.07450267977562315,1.1278281058982154,507]
["High","P10070-1","Isoform 1 of Zinc finger protein GLI2 [OS=Homo sapiens]",5,4,5,2,1258,133.2,7.14,12.6,"","","","GLI2","","","","",106,60,109.4,116.4,109.3,122.1,0.7918343875790684,-0.33672937317162305,0.21408324770279774,0.6694173154934306,0.4562123357160056,0.340832975830608,3664]
["High","P10109","Adrenodoxin, mitochondrial [OS=Homo sapiens]",16,2,10,2,184,19.4,5.83,18.72,"other metabolic processes;other biological processes","mitochondrion","other molecular function","FDX1","ENSG00000137714","","Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin","",163.4,183.6,179,155.6,118,132.1,1.2965245255114617,0.3746494969733919,0.033092660594687635,1.48026831488485,0.18562319965755825,0.7313677455007578,1392]
["High","P10398-1","serine/threonine-protein kinase A-Raf [OS=Homo sapiens]",21,10,14,7,606,67.5,9.01,21.9,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","ARAF","ENSG00000078061; ENSGGOG00000008695; ENSPPAG00000015632; ENSPTRG00000021846","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Common pathways underlying drug addiction; Bladder cancer; MAPK signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Alzheimer's disease; ErbB signaling pathway","Signaling by BRAF and RAF1 fusions; RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; FoxO signaling pathway; Vascular smooth muscle contraction; Natural killer cell mediated cytotoxicity; Long-term potentiation; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Parathyroid hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Pathways in cancer; Proteoglycans in cancer; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer",820.3,1025.9,878.5,874,986.1,919.6,0.9802136921250494,-0.028831795698412162,0.8044375119696846,0.0945076858853497,0.8901712150594242,0.05052645335047764,7056]
["High","P10620","Microsomal glutathione S-transferase 1 [OS=Homo sapiens]",23,3,16,3,155,17.6,9.39,26.69,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGST1","ENSG00000008394","Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Oxidative stress response; Metapathway biotransformation Phase I and II","Neutrophil degranulation; Aflatoxin activation and detoxification; Glutathione conjugation","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",779.5,842,795.7,719,951.3,847.2,0.9601588877855014,-0.05865493108183811,0.6566901884310643,0.18263947243188192,0.7995379683876112,0.09716090769048563,6413]
["High","P10809","60 kDa heat shock protein, mitochondrial [OS=Homo sapiens]",83,51,1952,51,573,61,5.87,4312.07,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","HSPD1","ENSG00000144381","Apoptosis-related network due to altered Notch3 in ovarian cancer; Sudden infant death syndrome (SIDS) susceptibility pathways","Mitochondrial protein import; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation","RNA degradation; Type I diabetes mellitus; Legionellosis; Tuberculosis; Lipid and atherosclerosis",44654.6,42573.9,43775.7,43167.6,42084,43298.2,1.0190929896429244,0.02728569976263929,0.31656253113949967,0.4995404902391131,0.5590862345933529,0.25252120048635174,4421]
["High","P11137","microtubule-associated protein 2 [OS=Homo sapiens]",8,10,19,3,1827,199.4,4.91,47.97,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAP2","ENSG00000078018","Melatonin metabolism and effects; MAPK cascade; Sudden infant death syndrome (SIDS) susceptibility pathways","","",724.1,767.9,644.4,589.8,485,510.4,1.347716376482463,0.43051691692415095,0.018641276396345725,1.7295243541649095,0.14584277164595935,0.8361150907936451,998]
["High","P11177","Pyruvate dehydrogenase E1 component subunit beta, mitochondrial [OS=Homo sapiens]",48,13,113,13,359,39.2,6.65,231.16,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","PDHB","ENSG00000168291","Metabolic reprogramming in colon cancer; Orexin receptor pathway","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Glycolysis / Gluconeogenesis; Citrate cycle (TCA cycle); Pyruvate metabolism; Metabolic pathways; Carbon metabolism; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer; Diabetic cardiomyopathy",4898.7,4862.7,5111.3,4988.3,5217.8,5191.9,0.9658851798934925,-0.050076396761874385,0.17460435889310746,0.7579449185938268,0.4131244952234494,0.38391905381307895,3300]
["High","P11233","Ras-related protein Ral-A [OS=Homo sapiens]",42,9,54,5,206,23.6,7.11,136.81,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","RALA","ENSG00000006451","RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; p38MAPK events","Ras signaling pathway; Rap1 signaling pathway; Phospholipase D signaling pathway; Salmonella infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer",2015.6,1851.5,2036.7,1882.5,1974.8,1892.3,1.0268192569917907,0.038182257615417096,0.47613370323270143,0.32227107580352743,0.67877523367554,0.1682740120736772,5477]
["High","P11441","Ubiquitin-like protein 4A [OS=Homo sapiens]",29,4,8,4,157,17.8,8.66,12.29,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;cytosol;nucleus;other cell component","other molecular function","UBL4A","ENSG00000102178","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",124.1,185.4,176.1,217.1,168.5,170.4,0.8733812949640287,-0.19531646135518782,0.39806981418469717,0.4000407539156663,0.6255039462978699,0.20376994600256368,4969]
["High","P11717","Cation-independent mannose-6-phosphate receptor [OS=Homo sapiens]",25,50,104,50,2491,274.2,5.94,235.02,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","IGF2R","ENSG00000197081","","Retrograde transport at the Trans-Golgi-Network; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis","Lysosome; Endocytosis",3871.6,4138.5,3993.6,4083,4154.2,4149.4,0.9690875623657824,-0.04530106796362354,0.18799159478886382,0.725861567855569,0.42769183336580674,0.3688690423736014,3432]
["High","P12036","Neurofilament heavy polypeptide [OS=Homo sapiens]",4,4,11,2,1026,112.4,6.18,23.38,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","NEFH","ENSG00000100285","Amyotrophic lateral sclerosis (ALS); Physico-chemical features and toxicity-associated pathways","","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",36.2,34.7,40.9,22.3,36.1,28.3,1.2895040369088813,0.3668162896213552,0.13065735537697565,0.8838661365702833,0.3575789101939803,0.4466281035687243,2853]
["High","P12259","Coagulation factor V [OS=Homo sapiens]",0,1,2,1,2224,251.5,6.05,4.92,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","F5","ENSG00000198734","Blood clotting cascade; Complement and coagulation cascades","COPII-mediated vesicle transport; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Platelet degranulation ; Cargo concentration in the ER; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",99.9,133.3,121.8,76.1,78.2,97.1,1.4120922832140015,0.49783437485889886,0.043555816991690914,1.360953835634756,0.20774820957307433,0.6824627103880618,1637]
["High","P12277","Creatine kinase B-type [OS=Homo sapiens]",77,19,172,18,381,42.6,5.59,440.14,"other metabolic processes;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","kinase activity;other molecular function","CKB","ENSG00000166165","","RND3 GTPase cycle; Creatine metabolism","Arginine and proline metabolism; Metabolic pathways",4465.6,5393.7,4519.3,4093.3,3876.7,3861.7,1.2152606979554923,0.281265834245321,0.05197212069127324,1.284229561689224,0.22939418787872326,0.6394175899403118,1769]
["High","P12955","xaa-Pro dipeptidase [OS=Homo sapiens]",33,15,47,15,493,54.5,6,105.32,"protein metabolism;other metabolic processes","","other molecular function","PEPD","ENSG00000124299","","","",1574.5,1583.6,1595.7,1510.9,1519.6,1505.4,1.0480389779316124,0.0676923735766363,6.0470075187659723E-4,3.2184594913979376,0.030659113445795267,1.5134404075757653,154]
["Medium","P13056-1","Nuclear receptor subfamily 2 group C member 1 [OS=Homo sapiens]",1,1,1,1,603,67.3,6.32,1.83,"signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NR2C1","ENSG00000120798","","Nuclear Receptor transcription pathway; SUMOylation of intracellular receptors","",25.2,28,19.2,36,28.8,27.8,0.7818574514038878,-0.35502249617703074,0.13979339632644175,0.8545133436598981,0.3691264249296102,0.43282486352738025,2957]
["High","P13533","myosin-6 [OS=Homo sapiens]",3,5,14,3,1939,223.6,5.73,30.89,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYH6","ENSG00000197616","Cardiac progenitor differentiation; Striated muscle contraction pathway; Acute viral myocarditis; IL-18 signaling pathway","Striated Muscle Contraction","cGMP-PKG signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Thyroid hormone signaling pathway; Hypertrophic cardiomyopathy; Dilated cardiomyopathy; Viral myocarditis",86.6,110.3,112.7,119.6,91.3,109,0.9678024382619568,-0.04721552097126363,0.7842474526407663,0.10554688328479858,0.8786632386596505,0.056177543146061035,6969]
["Medium","P13682","Zinc finger protein 35 [OS=Homo sapiens]",2,1,1,1,527,59.1,8.09,0,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF35","ENSG00000169981; ENSG00000281306","","","",43.3,46.1,44.8,29.8,42.9,42.2,1.167972149695387,0.22400587355406987,0.21161802215303016,0.6744473489793891,0.45330960685071586,0.3436050769747471,3645]
["Medium","P13726-1","tissue factor [OS=Homo sapiens]",5,2,4,1,295,33,7.03,7.18,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","F3","ENSG00000117525","Blood clotting cascade; VEGFA-VEGFR2 signaling pathway; Macrophage markers; STING pathway in Kawasaki-like disease and COVID-19; Complement and coagulation cascades","NGF-stimulated transcription; Extrinsic Pathway of Fibrin Clot Formation","Complement and coagulation cascades; AGE-RAGE signaling pathway in diabetic complications",171.9,167.1,158.5,159.9,165.1,169.8,1.005456750202102,0.007851025342003878,0.8618616720506108,0.06456243241873175,0.9233556442605886,0.03463099172503816,7288]
["High","P13984","General transcription factor IIF subunit 2 [OS=Homo sapiens]",58,13,28,13,249,28.4,9.23,46.49,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","GTF2F2","ENSG00000188342","Eukaryotic transcription initiation","Estrogen-dependent gene expression; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","Basal transcription factors",1461,1477.6,1368.1,1467.3,1285.8,1438.4,1.0274841942025528,0.039116201088483786,0.5908827300763833,0.2284987031023008,0.7583189277508877,0.12014810382462617,6084]
["Medium","P14415","sodium/potassium-transporting ATPase subunit beta-2 [OS=Homo sapiens]",3,1,1,1,290,33.3,8.31,2.01,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ATP1B2","ENSG00000129244","Calcium regulation in cardiac cells","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS; Basigin interactions","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption",28.9,34.3,39.7,30.3,32.2,32.2,1.0865892291446675,0.11980665142558367,0.43868786513566926,0.3578443787646626,0.65367840667544,0.18463586108975386,5240]
["High","P14550","alcohol dehydrogenase [NADP(+)] [OS=Homo sapiens]",66,20,102,19,325,36.6,6.79,241.94,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","AKR1A1","ENSG00000117448","Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II","Glutathione conjugation; Formation of xylulose-5-phosphate","Glycolysis / Gluconeogenesis; Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Glycerolipid metabolism; Pyruvate metabolism; Metabolic pathways; Biosynthesis of cofactors; Chemical carcinogenesis",4464.7,4091.1,4443,4178,4172.4,4018.9,1.050892128091323,0.07161458723083938,0.18664582027304305,0.7289817311739379,0.4268689410345402,0.36970544329401733,3414]
["High","P14859-1","POU domain, class 2, transcription factor 1 [OS=Homo sapiens]",15,8,23,8,743,76.4,6.81,50.59,"other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","POU2F1","ENSG00000143190","Integrated cancer pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling","Herpes simplex virus 1 infection; Lipid and atherosclerosis",605.6,521.3,591.4,647.5,615.5,644.7,0.9007181422655556,-0.1508523743893801,0.08714281927504566,1.0597683937256144,0.294550273982492,0.5308405689591232,2310]
["High","P14868","Aspartate--tRNA ligase, cytoplasmic [OS=Homo sapiens]",65,29,143,29,501,57.1,6.55,308.42,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","DARS1","ENSG00000115866","Alanine and aspartate metabolism","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",6725.6,6000.2,6618.1,6693.7,7382.6,7153.3,0.9111759053397145,-0.1341984972119542,0.10709658092315583,0.970224393873177,0.3263895799562844,0.48626371462320916,2562]
["High","P15260","Interferon gamma receptor 1 [OS=Homo sapiens]",4,2,3,2,489,54.4,4.91,3.74,"stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","IFNGR1","ENSG00000027697","Immune response to tuberculosis; Selective expression of chemokine receptors during T-cell polarization; Overview of interferons-mediated signaling pathway; Neuroinflammation and glutamatergic signaling; Type II interferon signaling (IFNG)","Potential therapeutics for SARS; Regulation of IFNG signaling","Cytokine-cytokine receptor interaction; HIF-1 signaling pathway; Necroptosis; Osteoclast differentiation; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Th1 and Th2 cell differentiation; Th17 cell differentiation; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Inflammatory bowel disease",96.5,91.9,97.3,87.7,66,80.8,1.2183368869936033,0.2849131135336329,0.061418094339727045,1.2117036628291322,0.24693742564602922,0.6074130837424829,1942]
["High","P15559-1","NAD(P)H dehydrogenase [quinone] 1 [OS=Homo sapiens]",31,7,15,7,274,30.8,8.88,40.65,"cell-cell signaling;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","NQO1","ENSG00000181019; ENSGGOG00000003294; ENSPTRG00000008284","Dopamine metabolism; Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Interactions between LOXL4 and oxidative stress pathway; Benzene metabolism; Oxidative stress response; NRF2-ARE regulation; Male infertility; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Estrogen metabolism","Regulation of ornithine decarboxylase (ODC)","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Pathways in cancer; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",887.8,754.1,907.4,857.9,982.1,871.1,0.9403194275386376,-0.08877716975270958,0.4349379416234079,0.36157270519062845,0.6521980887642729,0.1856204782076854,5207]
["High","P16050","arachidonate 15-lipoxygenase [OS=Homo sapiens]",3,2,2,2,662,74.8,6.58,4.95,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","ALOX15","ENSG00000161905","Eicosanoid synthesis; Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence","Interleukin-4 and Interleukin-13 signaling; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of E-series 18(R)-resolvins; Biosynthesis of DPAn-3-derived protectins and resolvins; Biosynthesis of DPAn-6 SPMs","Arachidonic acid metabolism; Linoleic acid metabolism; Metabolic pathways; Ferroptosis; Necroptosis; Serotonergic synapse",143.8,130.2,167.4,133.3,129.9,110.6,1.1808453718566074,0.2398200605344555,0.1571741947687526,0.8036187559396532,0.3907087273971412,0.40814688767952245,3141]
["High","P16083","Ribosyldihydronicotinamide dehydrogenase [quinone] [OS=Homo sapiens]",55,9,27,9,231,25.9,6.29,54.3,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","NQO2","ENSG00000124588","Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling","Phase I - Functionalization of compounds","",1075.3,1180.3,1019,1133.6,1107.4,1125.1,0.9728172068565997,-0.039759347985856744,0.5588397437039221,0.25271271519650645,0.7359454745893445,0.13315436088283483,5929]
["High","P16383-1","GC-rich sequence DNA-binding factor 2 [OS=Homo sapiens]",19,11,17,11,781,89.3,5.99,39.09,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity","GCFC2","ENSG00000005436","","mRNA Splicing - Major Pathway","",589,606.8,570.4,706.2,596.4,648.3,0.905325747091086,-0.14349111025477584,0.13913518279468734,0.8565630370708058,0.36876018576405933,0.43325597491878254,2946]
["High","P16435","NADPH--cytochrome P450 reductase [OS=Homo sapiens]",55,33,95,33,677,76.6,5.58,193.45,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","POR","ENSG00000127948","Oxidation by cytochrome P450; Ferroptosis","Cytochrome P450 - arranged by substrate type","",4003.3,4065.7,4276.7,3688.7,4023.7,3925.7,1.0608003024548682,0.08515309190370801,0.14229868568074294,0.8467991111893408,0.37184341961018774,0.4296398996740665,2988]
["High","P16989-1","Y-box-binding protein 3 [OS=Homo sapiens]",66,17,93,12,372,40.1,9.77,253.02,"stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CSDA; YBX3","ENSG00000060138","RalA downstream regulated genes; Apoptosis-related network due to altered Notch3 in ovarian cancer","","Tight junction",2291.5,2269.4,2147.6,2427.9,2222.2,2254.6,0.9715845728272045,-0.04158851236766648,0.4487882708269863,0.3479585019784588,0.6595405267489383,0.18075851322956055,5313]
["High","P17081","Rho-related GTP-binding protein RhoQ [OS=Homo sapiens]",9,2,16,1,205,22.6,6.32,40.42,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","other molecular function","RHOQ","ENSG00000119729","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling","RHOQ GTPase cycle; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases regulate CFTR trafficking","Insulin signaling pathway",32.4,32.5,38.6,44.2,28.6,40.6,0.9126984126984126,-0.13178987255554148,0.5559721991236843,0.2549469243694528,0.7336540359570267,0.13450868898782933,5917]
["High","P17096-2","Isoform HMG-Y of High mobility group protein HMG-I/HMG-Y [OS=Homo sapiens]",49,5,11,1,96,10.7,10.32,23.63,"","","","HMGA1","","","","",759.1,591.5,708.5,646.9,577,463.2,1.2204967103313378,0.2874684065528553,0.16461774004006274,0.7835233648323732,0.400665621643644,0.3972179197858637,3208]
["High","P17600-2","Isoform IB of Synapsin-1 [OS=Homo sapiens]",24,11,19,11,669,70,9.88,29.56,"","","","SYN1","","","","",458.8,498.3,424.6,369.8,372.7,368.1,1.244102287052044,0.31510510520821194,0.013312307267480531,1.8757466667871852,0.12448203011315927,0.9048933376121518,835]
["High","P17844","probable ATP-dependent RNA helicase DDX5 [OS=Homo sapiens]",56,38,292,29,614,69.1,8.92,601.5,"RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX5","ENSG00000108654","Ciliary landscape","Estrogen-dependent gene expression; mRNA Splicing - Major Pathway; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome; SUMOylation of transcription cofactors","Spliceosome; Transcriptional misregulation in cancer; Proteoglycans in cancer",13302.4,13863.1,13447.2,13380.2,14092.3,14029.1,0.978581548663184,-0.03123601414285464,0.3540277980610114,0.4509626360800658,0.5905253251998243,0.22876147254887252,4681]
["High","P17858-1","ATP-dependent 6-phosphofructokinase, liver type [OS=Homo sapiens]",44,26,65,22,780,85,7.5,161.78,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;other cell component","kinase activity;other molecular function","PFKL","ENSG00000141959; ENSPTRG00000022972","Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Insulin signaling; Glycolysis and gluconeogenesis","Neutrophil degranulation; Glycolysis","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Galactose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway; AMPK signaling pathway; Thyroid hormone signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer",3007,2758.7,3097,2956.6,3303.1,3017.5,0.955320570861898,-0.06594316447480023,0.4007971363425349,0.3970753901225425,0.6275163506241251,0.20237495368227015,4987]
["High","P18085","ADP-ribosylation factor 4 [OS=Homo sapiens]",79,10,76,6,180,20.5,7.14,177.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARF4","ENSG00000168374","VEGFA-VEGFR2 signaling pathway","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; VxPx cargo-targeting to cilium","Endocytosis",1784.1,1376.3,1715.3,1607.9,1892.5,1693.3,0.9387719737374126,-0.09115332285328767,0.523059068492763,0.2814492639588878,0.7110106557784632,0.1481238905344964,5744]
["High","P18583-5","Isoform D of Protein SON [OS=Homo sapiens]",23,38,165,8,2459,266.9,5.73,368.2,"","","","SON","","","","",5493.8,4893.7,5180.1,5832.7,5505.7,5583.1,0.9199893626451555,-0.12031091474793303,0.08637869063166755,1.0635933834761966,0.2926007880486161,0.5337245085432283,2305]
["High","P18669","Phosphoglycerate mutase 1 [OS=Homo sapiens]",81,19,241,19,254,28.8,7.18,546.26,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","PGAM1","ENSG00000171314","Cori cycle; Metabolic reprogramming in colon cancer; Glycolysis and gluconeogenesis","Neutrophil degranulation; Glycolysis; Gluconeogenesis","Glycolysis / Gluconeogenesis; Glycine, serine and threonine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Glucagon signaling pathway; Central carbon metabolism in cancer",9549,12810,9220,9879.3,9036.1,9443.6,1.1135442011354422,0.15515882574426176,0.41134659890796604,0.3857920891724438,0.6368816665225855,0.19594125267294182,5043]
["High","P19012","Keratin, type I cytoskeletal 15 [OS=Homo sapiens]",12,8,31,1,456,49.2,4.77,73.53,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","KRT15","ENSG00000171346","","Formation of the cornified envelope","Estrogen signaling pathway; Staphylococcus aureus infection",29.7,31.7,33.8,32.5,37.6,33,0.9233753637245392,-0.11501085406016498,0.26009955449552014,0.5848603916730353,0.5067009285182189,0.29524829987358914,4008]
["High","P19086","guanine nucleotide-binding protein G(z) subunit alpha [OS=Homo sapiens]",4,1,1,1,355,40.9,7.61,3.2,"signal transduction","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus","signal transduction activity or receptor binding;other molecular function","GNAZ","ENSG00000128266","Corticotropin-releasing hormone signaling pathway; G protein signaling pathways; Purinergic signaling; Calcium regulation in cardiac cells","G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; ADORA2B mediated anti-inflammatory cytokines production","Long-term depression",25.3,33.5,29,20.7,29.7,29.8,{"$f":"AVERAGE(T1474:V1474)/AVERAGE(W1474:Y1474)","v":1.0947630922693266},{"$f":"LOG(Z1474,2)","v":0.13061870308043771},{"$f":"TTEST(T1474:V1474,W1474:Y1474,2,2)","v":0.5451791421998264},{"$f":"-LOG10(AB1474)","v":0.2634607680259174},{"$f":"AB1474*7808/AF1474","v":0.7256663386117022},{"$f":"-LOG10(AD1474)","v":0.1392630220118153},5866]
["High","P19367-1","Hexokinase-1 [OS=Homo sapiens]",46,39,161,36,917,102.4,6.8,376.43,"other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion","kinase activity;other molecular function","HK1","ENSG00000156515","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Glycolysis and gluconeogenesis; Glucuronidation","Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)","Glycolysis / Gluconeogenesis; Fructose and mannose metabolism; Galactose metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Neomycin, kanamycin and gentamicin biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of nucleotide sugars; HIF-1 signaling pathway; Insulin signaling pathway; Type II diabetes mellitus; Carbohydrate digestion and absorption; Shigellosis; Central carbon metabolism in cancer",7573.1,6623.3,7987,7989.1,8780.4,8633.2,0.873269376877261,-0.19550134511195674,0.08501275837301435,1.07051589222453,0.2899867266826108,0.5376218802404374,2289]
["High","P19793","retinoic acid receptor RXR-alpha [OS=Homo sapiens]",11,4,5,4,462,50.8,7.8,7.86,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RXRA","ENSG00000186350","Vitamin D metabolism; Energy metabolism; Nuclear receptors; Adipogenesis; Liver X receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Vitamin D receptor pathway; PPAR-alpha pathway; Farnesoid X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Prion disease pathway; PI3K/AKT/mTOR - VitD3 signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Vitamins A and D - action mechanisms; Nonalcoholic fatty liver disease; Vitamin D in inflammatory diseases; Small cell lung cancer; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Vitamin A and carotenoid metabolism","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Regulation of pyruvate dehydrogenase (PDH) complex; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; SUMOylation of intracellular receptors; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Endogenous sterols; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Signaling by Retinoic Acid; Nuclear Receptor transcription pathway; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Recycling of bile acids and salts; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; Transcriptional regulation of granulopoiesis; RORA activates gene expression; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis","PPAR signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation; Thyroid hormone signaling pathway; Adipocytokine signaling pathway; Parathyroid hormone synthesis, secretion and action; Non-alcoholic fatty liver disease; Bile secretion; Hepatitis C; Pathways in cancer; Transcriptional misregulation in cancer; Chemical carcinogenesis; Thyroid cancer; Small cell lung cancer; Non-small cell lung cancer; Gastric cancer; Lipid and atherosclerosis",127.2,150.9,157.9,166.2,179,182.2,0.826697004171407,-0.27456943620027136,0.044007773344077655,1.3564706048259203,0.20901015466578973,0.6798326133713165,1644]
["High","P20073-1","Annexin A7 [OS=Homo sapiens]",36,16,55,16,488,52.7,5.68,88.88,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ANXA7","ENSG00000138279","","","Amyotrophic lateral sclerosis",1836.6,1453.3,1882.5,1712.9,1877,1756.7,0.9674185463659147,-0.04778789895426545,0.7086016692228495,0.14959782895257517,0.8331217939003176,0.07929150453278384,6641]
["High","P20337","Ras-related protein Rab-3B [OS=Homo sapiens]",48,8,31,6,219,24.7,5.02,55.97,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3B","ENSG00000169213","Intracellular trafficking proteins involved in CMT neuropathy","RAB geranylgeranylation","",731,683.2,841.9,818.4,927.2,886.7,0.8570831592143752,-0.2224929050586471,0.09154436015705743,1.0383684064482135,0.3027439068641696,0.5189245888683051,2361]
["High","P20340-2","Isoform 2 of Ras-related protein Rab-6A [OS=Homo sapiens]",53,14,46,10,208,23.5,5.54,85.21,"","","","RAB6A","","","","",3110.4,3291.1,3572.2,3454.7,4103,3765.6,0.8808121307392723,-0.1830937567334042,0.12262778544822174,0.9114111146492778,0.3480471642238151,0.4583619003803259,2751]
["High","P20936-1","ras GTPase-activating protein 1 [OS=Homo sapiens]",10,8,17,8,1047,116.3,6.54,37.16,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RASA1","ENSG00000145715","PDGF pathway; T cell receptor and co-stimulatory signaling; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; EPO receptor signaling","Regulation of RAS by GAPs; VEGFR2 mediated cell proliferation; EPHB-mediated forward signaling; Downstream signal transduction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases","MAPK signaling pathway; Ras signaling pathway; Axon guidance",611.8,596.7,598.9,553.1,540.2,550.5,1.099525489718944,0.13688104981803417,8.8766083672419185E-4,3.051752940612859,0.0362872032101701,1.4402465032019514,191]
["High","P21283","V-type proton ATPase subunit C 1 [OS=Homo sapiens]",37,14,26,14,382,43.9,7.46,50.96,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity","ATP6V1C1","ENSG00000155097","Proximal tubule transport","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",1853.7,1683.5,1774.7,1677,1686.1,1693.7,1.0504469229552285,0.07100326727149016,0.16037325542411632,0.7948680549431291,0.39601340238820376,0.40229011588068386,3162]
["High","P21709","Ephrin type-A receptor 1 [OS=Homo sapiens]",13,9,18,9,976,108.1,6.64,29.06,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","EPHA1","ENSG00000146904; ENSG00000284816","","EPHA-mediated growth cone collapse; EPH-ephrin mediated repulsion of cells; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","Axon guidance",1198.2,1132.2,1161,1169.3,1204.4,1237.1,0.9669325357261549,-0.04851286058201381,0.21935007361582923,0.6588622155059335,0.46213852530825544,0.33522782583017685,3706]
["High","P21926","CD9 antigen [OS=Homo sapiens]",30,8,35,8,228,25.4,7.15,61.17,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","CD9","ENSG00000010278","Vitamin D receptor pathway","Platelet degranulation ; Uptake and function of diphtheria toxin; Acrosome Reaction and Sperm:Oocyte Membrane Binding","Hematopoietic cell lineage",1447,2015.7,1417.2,1847.8,1773.9,1827.6,0.8955095149835759,-0.15921933364576127,0.38762750107147453,0.41158541856684294,0.6165401361511659,0.21003864600807692,4909]
["High","P22087","rRNA 2'-O-methyltransferase fibrillarin [OS=Homo sapiens]",53,19,122,16,321,33.8,10.18,265.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","FBL","ENSG00000105202; ENSG00000280548","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",5417.3,6834.3,5383.4,5179.4,5688.8,5685.7,1.065307873069186,0.09127042834972282,0.5166007163460766,0.2868449959464172,0.7079007359126301,0.15002763619123985,5698]
["High","P22307-1","Non-specific lipid-transfer protein [OS=Homo sapiens]",30,13,48,13,547,59,6.89,87.75,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","SCP2","ENSG00000116171","PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; DNA damage response (only ATM dependent)","TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism","Primary bile acid biosynthesis; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome",1669.8,1925.2,1710.3,2093,1924.5,1869.9,0.9011278323198697,-0.1501963162932023,0.13513476870216412,0.8692328973672209,0.36383871518155086,0.43909109060754153,2900]
["High","P22626","heterogeneous nuclear ribonucleoproteins A2/B1 [OS=Homo sapiens]",91,30,462,27,353,37.4,8.95,1127.2,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPA2B1","ENSG00000122566","mRNA processing","mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Processing of Capped Intron-Containing Pre-mRNA","Amyotrophic lateral sclerosis",20311.6,23645.5,20530.5,22637.4,22507.7,23059.2,0.9455063683668038,-0.0808409195465242,0.3189693087160867,0.496251102825225,0.5614320023568992,0.2507028356437121,4436]
["High","P23142","Fibulin-1 [OS=Homo sapiens]",15,8,12,8,703,77.2,5.22,29.01,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;extracellular matrix","signal transduction activity or receptor binding;enzyme regulator activity;extracellular structural activity;other molecular function","FBLN1","ENSG00000077942","","Molecules associated with elastic fibres","",275,260.9,252.6,237.6,250.1,258.9,1.0561210822394858,0.07877524637480292,0.19550386930946545,0.7088446428557332,0.4367651535245511,0.3597520182787981,3495]
["High","P23368-1","NAD-dependent malic enzyme, mitochondrial [OS=Homo sapiens]",41,14,61,14,584,65.4,7.61,109.36,"other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","ME2","ENSG00000082212","TCA cycle in senescence","Citric acid cycle (TCA cycle)","Pyruvate metabolism; Carbon metabolism",1412.8,1324.4,1514.2,1553.6,1693.5,1631.1,0.8715099831905211,-0.19841090429777333,0.03744177928311961,1.4266435211924886,0.19386300573116574,0.7125050580676084,1508]
["High","P23458","Tyrosine-protein kinase JAK1 [OS=Homo sapiens]",4,4,6,4,1154,133.2,7.55,12.61,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK1","ENSG00000162434","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-17 signaling pathway; Type III interferon signaling; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Overview of interferons-mediated signaling pathway; Measles virus infection; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; TGF-beta receptor signaling in skeletal dysplasias; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; IL-2 signaling pathway; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; Malignant pleural mesothelioma; TGF-beta receptor signaling; Interferon type I signaling pathways; Type II interferon signaling (IFNG)","Potential therapeutics for SARS; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Interleukin-4 and Interleukin-13 signaling; Interleukin-6 signaling; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; IL-6-type cytokine receptor ligand interactions; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-27 signaling; ISG15 antiviral mechanism; Interleukin-10 signaling; Interleukin-7 signaling; Regulation of IFNA signaling; Interleukin-2 signaling; Other interleukin signaling; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling","EGFR tyrosine kinase inhibitor resistance; PI3K-Akt signaling pathway; Necroptosis; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; NOD-like receptor signaling pathway; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Pancreatic cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer",172.1,170,162.5,146.6,144.7,162,1.113170086035738,0.15467404509031535,0.051050767461997146,1.2919977246445522,0.22829575735582688,0.6415021593554676,1746]
["High","P23511","Nuclear transcription factor Y subunit alpha [OS=Homo sapiens]",5,1,7,1,347,36.9,8.94,6.86,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFYA","ENSG00000001167","Sterol regulatory element-binding proteins (SREBP) signaling; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways","ATF4 activates genes in response to endoplasmic reticulum  stress; PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF6 (ATF6-alpha) activates chaperone genes","Antigen processing and presentation; Spinocerebellar ataxia; Tuberculosis",101,122.2,95.6,98.9,93.4,93.2,1.1166374781085813,0.15916088374026643,0.25351806578468833,0.5959910872535445,0.5001185087536247,0.3009270724652865,3958]
["High","P24385","G1/S-specific cyclin-D1 [OS=Homo sapiens]",16,3,3,2,295,33.7,5.02,9.57,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCND1","ENSG00000110092","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Leptin signaling pathway; IL-7 signaling pathway; Glioblastoma signaling pathways; Spinal cord injury; Retinoblastoma gene in cancer; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Mammary gland development pathway - Puberty (Stage 2 of 4); Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Bladder cancer; Mesodermal commitment pathway; Vitamin D receptor pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; Focal adhesion; Copper homeostasis; Photodynamic therapy-induced NF-kB survival signaling; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; Non-small cell lung cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Wnt signaling; Acute viral myocarditis; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; G1 to S cell cycle control; Hippo-Merlin signaling dysregulation; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Melanoma; FGF23 signaling in hypophosphatemic rickets and related disorders; EGFR tyrosine kinase inhibitor resistance; Influence of laminopathies on Wnt signaling; Development of ureteric collection system; Malignant pleural mesothelioma; Notch signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)","Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Cyclin D associated events in G1; Interleukin-4 and Interleukin-13 signaling; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Transcriptional Regulation by VENTX; RMTs methylate histone arginines; Transcriptional regulation by RUNX2; RUNX3 regulates WNT signaling; RUNX3 regulates p14-ARF; PTK6 Regulates Cell Cycle; Regulation of RUNX1 Expression and Activity","Endocrine resistance; FoxO signaling pathway; Cell cycle; p53 signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Cellular senescence; Wnt signaling pathway; Hedgehog signaling pathway; Apelin signaling pathway; Hippo signaling pathway; Focal adhesion; Tight junction; JAK-STAT signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Alcoholic liver disease; Hepatitis C; Measles; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Viral myocarditis",59.6,30.5,73,47.3,48.7,46.1,1.1477832512315271,0.19885022746910405,0.6072151348095423,0.21665741220751553,0.7686666297978122,0.11426197259178071,6168]
["Low","P24864-1","G1/S-specific cyclin-E1 [OS=Homo sapiens]",2,1,1,1,410,47,6.04,0,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNE1","ENSG00000105173","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; ATM signaling pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Malignant pleural mesothelioma; ID signaling pathway; DNA damage response","CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; G1/S-Specific Transcription; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); RHOBTB3 ATPase cycle; DNA Damage/Telomere Stress Induced Senescence; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle","Cell cycle; Oocyte meiosis; p53 signaling pathway; PI3K-Akt signaling pathway; Cellular senescence; Cushing syndrome; Hepatitis B; Measles; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Prostate cancer; Small cell lung cancer; Gastric cancer",22.1,16.4,25.3,26.3,29.2,30.4,0.7427240977881256,-0.4291017073735944,0.06238125539353847,1.2049458895179535,0.2488875023570508,0.6039969105173193,1957]
["High","P25205","DNA replication licensing factor mcm3 [OS=Homo sapiens]",65,46,326,46,808,90.9,5.77,658.4,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3","ENSG00000112118","Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Unwinding of DNA","DNA replication; Cell cycle",11157.1,9607,11276.4,12050.6,12015.6,12105.2,0.885796513267388,-0.17495277648751145,0.06277750288949151,1.2021959632916477,0.24995754337641493,0.6021337523007964,1961]
["High","P25490","Transcriptional repressor protein YY1 [OS=Homo sapiens]",28,9,22,9,414,44.7,6.25,49.12,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","YY1","ENSG00000100811","Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Malignant pleural mesothelioma","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; UCH proteinases; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors","",1081.3,1169,990,1069.5,991.2,1014.3,1.0537560975609757,0.07554097934816836,0.38585918080616405,0.4135711620564472,0.615357124945778,0.2108727665353165,4896]
["High","P25788-1","Proteasome subunit alpha type-3 [OS=Homo sapiens]",40,13,55,13,255,28.4,5.33,117.92,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMA3","ENSCANG00000039836; ENSCATG00000039369; ENSCJAG00000018732; ENSCSAG00000014435; ENSG00000100567; ENSGGOG00000015814; ENSMFAG00000002833; ENSMLEG00000041984; ENSMMUG00000003509; ENSMNEG00000035144; ENSNLEG00000013092; ENSPANG00000007163; ENSPPAG00000035468; ENSPPYG00000005855; ENSPTRG00000006390; ENSRROG00000040700; ENSSBOG00000021565","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",3793.1,2803.7,3917.3,3829.2,4265.8,4061.2,0.864916668037709,-0.20936695450804785,0.21737922346849511,0.6627819669846623,0.46009676791596904,0.33715081755283033,3689]
["High","P26358-1","DNA (cytosine-5)-methyltransferase 1 [OS=Homo sapiens]",46,63,199,1,1616,183.1,7.75,415.46,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT1","ENSG00000130816","Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency","NoRC negatively regulates rRNA expression; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer",300,346.3,289.3,303.6,264.5,270.6,1.1155359484917131,0.15773700562604007,0.20390686149296,0.6905681599089987,0.44684388844710404,0.3498441776013788,3563]
["High","P26572","alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [OS=Homo sapiens]",5,2,2,2,445,50.8,9.16,6.61,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MGAT1","ENSG00000131446","","Maturation of spike protein; Maturation of spike protein; N-glycan trimming and elongation in the cis-Golgi","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways",193.7,153.9,216.2,165.9,213.8,199.8,0.9729076790336496,-0.03962518332341247,0.8319325496583068,0.07991188344325467,0.9065916744915644,0.042588273517982556,7165]
["High","P26641","elongation factor 1-gamma [OS=Homo sapiens]",72,29,252,29,437,50.1,6.67,477.94,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","EEF1G","ENSG00000254772","Translation factors","Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation","Legionellosis",9880.3,11303.2,9963.2,9422.1,9798.8,9524,1.0835556916183393,0.11577330567596641,0.16692024378367437,0.7774909896814691,0.40325286617046086,0.39442253712538233,3232]
["High","P27348","14-3-3 protein theta [OS=Homo sapiens]",69,21,560,15,245,27.7,4.78,1098.18,"transport;signal transduction;other biological processes","cytosol;other cell component","other molecular function","YWHAQ","ENSG00000134308","Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria","Cell cycle; Oocyte meiosis; PI3K-Akt signaling pathway; Hippo signaling pathway; Hepatitis C; Hepatitis B; Viral carcinogenesis",13884.7,12949.7,15148,14735.5,15148.2,13963.2,0.9574770394258203,-0.06269020367606173,0.43991185995869425,0.35663432935029177,0.653506811749902,0.1847498812433807,5256]
["High","P27635","60S ribosomal protein L10 [OS=Homo sapiens]",46,11,154,11,214,24.6,10.08,304.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPL10","ENSG00000147403","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",3850.3,4031.7,4189.6,4232.8,3773.5,3761,1.02585979791456,0.036833574342057904,0.6100187897441037,0.21465678768349003,0.7700932433826939,0.11345668698999409,6185]
["High","P27816-5","Isoform 5 of Microtubule-associated protein 4 [OS=Homo sapiens]",42,29,83,1,809,85.2,7.71,105.85,"","","","MAP4","","","","",116.1,110.8,121.8,115,140.4,126.1,0.9140235910878113,-0.1296966929451883,0.24392441587418337,0.6127447263417934,0.4925166379999027,0.3075790937562235,3867]
["High","P28070","Proteasome subunit beta type-4 [OS=Homo sapiens]",48,8,60,8,264,29.2,5.97,122.95,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","other molecular function","PSMB4","ENSG00000159377","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of RUNX2 expression and activity; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint; UCH proteinases; Regulation of RUNX3 expression and activity; Regulation of ornithine decarboxylase (ODC); ROS sensing by NFE2L2; Regulation of PTEN stability and activity; Regulation of RAS by GAPs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",1074.3,976,1140.8,1109.3,1254.4,1162.5,0.9049685213544327,-0.14406048487460438,0.15553537861601174,0.8081708092730245,0.38774592472344177,0.4114527580002949,3132]
["Low","P28332-1","Alcohol dehydrogenase 6 [OS=Homo sapiens]",3,1,1,1,368,39.1,7.77,0,"","","","","","","","",83.7,68.8,89.8,76.6,95.3,93.8,0.9119307489649982,-0.13300382303916014,0.4183747968687041,0.3784344854948114,0.6414039689673752,0.19286835701235414,5093]
["High","P28799","Granulins [OS=Homo sapiens]",4,2,3,2,593,63.5,6.83,6.9,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GRN","ENSG00000030582","IL-18 signaling pathway","Neutrophil degranulation","",290.5,250.6,265.2,240.5,215.6,254.8,1.1341960894640595,0.1816700872299783,0.12351640047769458,0.9082753730596078,0.34879423324768144,0.4574307040416895,2765]
["High","P29084","transcription initiation factor iie subunit beta [OS=Homo sapiens]",41,10,40,9,291,33,9.66,62.58,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","GTF2E2","ENSG00000197265","Eukaryotic transcription initiation","RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors; Viral carcinogenesis",1268.7,1373.8,1307.7,1255.1,1085.8,1199.6,1.1157181189097587,0.1579725828856043,0.07990781825927051,1.0974107268093138,0.28231685292687064,0.5492631958357892,2210]
["High","P29353","SHC-transforming protein 1 [OS=Homo sapiens]",31,12,25,12,583,62.8,6.44,61.33,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","signal transduction activity or receptor binding;other molecular function","SHC1","ENSG00000160691","IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; IL-4 signaling pathway; p38 MAPK signaling pathway; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; EGF/EGFR signaling pathway; Fragile X syndrome; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Malignant pleural mesothelioma; EPO receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)","Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Interleukin receptor SHC signaling; RET signaling; RAF/MAP kinase cascade; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; Signaling by CSF3 (G-CSF); XBP1(S) activates chaperone genes; SHC1 events in EGFR signaling; Integrin signaling; Erythropoietin activates RAS; Signalling to RAS; Signal attenuation; Interleukin-2 signaling; Interleukin-15 signaling","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; ErbB signaling pathway; Ras signaling pathway; Chemokine signaling pathway; Phospholipase D signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Insulin signaling pathway; Estrogen signaling pathway; Prolactin signaling pathway; Relaxin signaling pathway; Growth hormone synthesis, secretion and action; Alcoholism; Bacterial invasion of epithelial cells; MicroRNAs in cancer; Glioma; Chronic myeloid leukemia; Breast cancer; Hepatocellular carcinoma; Gastric cancer",1180,1148.8,1176.9,1116.7,1218.1,1155,1.0045561350220644,6.5581847333773735E-3,0.8732891328305075,0.0588419441483049,0.9297302357704667,0.031643045114253414,7334]
["High","P29401","Transketolase [OS=Homo sapiens]",70,36,535,36,623,67.8,7.66,1322.77,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","TKT","ENSG00000163931","Pentose phosphate metabolism; VEGFA-VEGFR2 signaling pathway; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways","Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",22693.1,26289,22651.1,23548.3,25163.1,25030.1,0.9714095861895947,-0.04184837146586539,0.6206182792310447,0.2071754371755291,0.7758225302971496,0.11023761241107356,6246]
["High","P30043","flavin reductase (NADPH) [OS=Homo sapiens]",35,5,13,5,206,22.1,7.65,29.56,"other metabolic processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","BLVRB","ENSG00000090013","Nuclear receptors meta-pathway; NRF2 pathway; IL-10 anti-inflammatory signaling pathway","Cytoprotection by HMOX1; Heme degradation","Riboflavin metabolism; Porphyrin metabolism; Metabolic pathways",340.4,357.6,357.1,376,310.5,337.2,1.0306730487447493,0.04358675194771047,0.6256762016638481,0.20365036361386119,0.7795244586869835,0.10817025365519681,6267]
["High","P30047","GTP cyclohydrolase 1 feedback regulatory protein [OS=Homo sapiens]",19,1,1,1,84,9.7,6.54,2.46,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","GCHFR","ENSG00000137880","","Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","",15.1,14.5,13.5,15.5,8,15.2,1.1136950904392764,0.15535430294468772,0.5883020044243165,0.23039967191012778,0.7567482785082477,0.12104855832674993,6070]
["High","P30153","serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [OS=Homo sapiens]",60,32,294,24,589,65.3,5.11,599.14,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP2R1A","ENSG00000105568","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Cyclin A/B1/B2 associated events during G2/M transition; Regulation of TP53 Degradation; Regulation of PLK1 Activity at G2/M Transition; Cyclin D associated events in G1; Spry regulation of FGF signaling; Negative regulation of MAPK pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; TGF-beta signaling pathway; Hippo signaling pathway; Tight junction; Dopaminergic synapse; Long-term depression; Chagas disease; Hepatitis C; Human papillomavirus infection",10538.4,10177.3,10319.7,10158.3,9932.1,10020.4,1.0307065903263943,0.04363370135245858,0.06771772727623787,1.1692976259906251,0.2608485518366381,0.5836115700249983,2027]
["High","P30291-1","Wee1-like protein kinase [OS=Homo sapiens]",10,6,9,6,646,71.6,6.77,14.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","WEE1","ENSG00000166483","Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control","Factors involved in megakaryocyte development and platelet production; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin A:Cdk2-associated events at S phase entry; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Polo-like kinase mediated events; G2/M DNA replication checkpoint; Cyclin E associated events during G1/S transition","Cell cycle; Human immunodeficiency virus 1 infection",259.7,305.2,280,241.2,256.2,272,1.0981284117494152,0.13504676851601077,0.18824802780432248,0.7252695650246676,0.4279011939144541,0.3686565017616014,3435]
["High","P30566","adenylosuccinate lyase [OS=Homo sapiens]",32,16,44,16,484,54.9,7.11,87.55,"other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","ADSL","ENSG00000239900","Nucleotide metabolism","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of cofactors",2614.8,2730.7,2641.2,2867.9,2791.9,2843.1,0.9392913006150843,-0.0903554473606506,0.014422664051310492,1.8409545124375133,0.12855269510574466,0.8909188139469586,876]
["High","P30825","High affinity cationic amino acid transporter 1 [OS=Homo sapiens]",8,4,7,3,629,67.6,5.43,7.41,"transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC7A1","ENSG00000139514","VEGFA-VEGFR2 signaling pathway","Amino acid transport across the plasma membrane","MicroRNAs in cancer",355.5,374.7,347.4,425.9,405.8,422.5,0.8591931111465476,-0.21894566878302618,0.004480522120922607,2.3486713741663467,0.07053209016162039,1.1516132459979087,496]
["High","P31040","Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [OS=Homo sapiens]",34,15,42,15,664,72.6,7.39,113.53,"other metabolic processes;developmental processes","other membranes;mitochondrion;nucleus","other molecular function","SDHA","ENSG00000073578","Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)","Respiratory electron transport; Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Oxidative phosphorylation; Metabolic pathways; Carbon metabolism; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",1617.6,1530.9,1571.3,1464.3,1460,1546.5,1.0556947302496198,0.07819271838521968,0.09234248707109834,1.034598432722841,0.30371109479828806,0.517539342682778,2374]
["High","P31350-1","ribonucleoside-diphosphate reductase subunit M2 [OS=Homo sapiens]",40,12,34,11,389,44.8,5.38,64.89,"cell organization and biogenesis;other metabolic processes;developmental processes","cytosol","other molecular function","RRM2","ENSG00000171848","Fluoropyrimidine activity; Retinoblastoma gene in cancer; Hepatitis C and hepatocellular carcinoma; Pyrimidine metabolism; Nucleotide metabolism; Orexin receptor pathway","G1/S-Specific Transcription; Transcriptional Regulation by E2F6; Interconversion of nucleotide di- and triphosphates","Purine metabolism; Pyrimidine metabolism; Glutathione metabolism; Drug metabolism; Metabolic pathways; p53 signaling pathway",968.3,802.6,1004.5,835.3,916.2,845.7,1.0686123517634376,0.09573859804056346,0.4263210782715325,0.3702631943275116,0.6477359367861696,0.18860200735404914,5139]
["High","P31689-1","DnaJ homolog subfamily A member 1 [OS=Homo sapiens]",65,20,120,20,397,44.8,7.08,309.2,"stress response;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","Dnaja1; DNAJA1; LOC109263810; LOC111146318; LOC112809310","ENSCAFG00000001474; ENSCAFG00000001818; ENSCATG00000033398; ENSCJAG00000008022; ENSCPOG00000000462; ENSECAG00000010324; ENSFCAG00000008729; ENSG00000086061; ENSGGOG00000007030; ENSLCNG00005016649; ENSMFAG00000032081; ENSMLEG00000042863; ENSMMUG00000007740; ENSMNEG00000030895; ENSNLEG00000005268; ENSOCUG00000004833; ENSPANG00000025299; ENSPPAG00000027533; ENSPPYG00000019141; ENSPTRG00000020852; ENSRROG00000029815; ENSSSCG00000011000; ENSSSCG00070018491; ENSSSUG00005020902; ENSSTOG00000005200","VEGFA-VEGFR2 signaling pathway; Exercise-induced circadian regulation","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","Protein processing in endoplasmic reticulum",4472.6,4661.2,4446,4434.8,4219.3,4385.9,1.0413957055214722,0.05851836250754693,0.12824001871083623,0.8919764272882509,0.3550702362036203,0.4496857309489765,2820]
["High","P31947-1","14-3-3 protein sigma [OS=Homo sapiens]",38,8,125,4,248,27.8,4.74,270.24,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","enzyme regulator activity;other molecular function","SFN","ENSG00000175793; ENSGGOG00000011493; ENSNLEG00000018582; ENSPPAG00000013397; ENSPTRG00000030723","miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; DNA damage response; Calcium regulation in cardiac cells","TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","Cell cycle; p53 signaling pathway; Aldosterone-regulated sodium reabsorption",301,268.7,289.9,310.7,313.3,327,0.9038906414300737,-0.14577985832014217,0.047016549285555015,1.3277492484827838,0.2179959719843311,0.661551530987779,1684]
["High","P32322","Pyrroline-5-carboxylate reductase 1, mitochondrial [OS=Homo sapiens]",39,9,34,8,319,33.3,7.61,98.14,"other metabolic processes;stress response;other biological processes","mitochondrion","other molecular function","PYCR1","ENSG00000183010","Amino acid metabolism; Metabolic reprogramming in colon cancer","Glutamate and glutamine metabolism","Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids",1466.4,1205.6,1499.7,1488.3,1632.5,1603.7,0.8829929093025717,-0.17952624224022354,0.1477990861929371,0.8303282510737491,0.3788625295451257,0.4215183454151375,3046]
["High","P32519-1","ETS-related transcription factor Elf-1 [OS=Homo sapiens]",9,4,4,4,619,67.5,5.21,8.15,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ELF1","ENSG00000120690; ENSGGOG00000010760","","RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX1 regulates transcription of genes involved in BCR signaling","",113.7,116.8,121.1,86.8,91.6,97.1,1.276225045372051,0.35188275168488425,0.002295054779688693,2.6392069440122996,0.052397040116401505,1.2806932454097992,342]
["High","P33897","ATP-binding cassette sub-family D member 1 [OS=Homo sapiens]",9,6,10,6,745,82.9,8.95,17.78,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ABCD1","ENSG00000101986","Vitamin D receptor pathway","Class I peroxisomal membrane protein import; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids; Linoleic acid (LA) metabolism; ABC transporters in lipid homeostasis; Defective ABCD1 causes ALD","ABC transporters; Peroxisome",467.7,713.1,489.5,445.7,452.7,420.7,1.2662421347888713,0.3405533078131207,0.21259615453471462,0.6724445953134646,0.45403467576779316,0.342910977716623,3656]
["Low","P34741","syndecan-2 [OS=Homo sapiens]",5,1,1,1,201,22.1,4.86,0,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SDC2","ENSG00000169439","miRNA targets in ECM and membrane receptors","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cell surface interactions at the vascular wall; Syndecan interactions; EPHB-mediated forward signaling; A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Cell adhesion molecules; Malaria; Proteoglycans in cancer; Fluid shear stress and atherosclerosis",126.1,128.7,159.4,164.3,151.4,182.9,0.8307260328920978,-0.267555329270989,0.11615672468456249,0.9349556424383644,0.3387940628827284,0.4700642089666616,2677]
["High","P34897-1","Serine hydroxymethyltransferase, mitochondrial [OS=Homo sapiens]",66,29,163,27,504,56,8.53,376.49,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","HEL-S-51e; SHMT2","ENSG00000182199","Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling","RHOG GTPase cycle; Metabolism of folate and pterines","Glycine, serine and threonine metabolism; Glyoxylate and dicarboxylate metabolism; One carbon pool by folate; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors; Antifolate resistance",6194.9,6547.5,6097.9,6007.4,6144,6190,1.0272007589387941,0.03871817349655912,0.3217229059410985,0.49251801721528643,0.5636106012089066,0.24902084664282745,4457]
["High","P35222","Catenin beta-1 [OS=Homo sapiens]",38,22,85,20,781,85.4,5.86,241.42,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CTNNB1","ENSG00000168036","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Heart development; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Gastric cancer network 2; Brain-derived neurotrophic factor (BDNF) signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Endoderm differentiation; Ectoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Focal adhesion; Ectoderm differentiation; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; OSX and miRNAs in tooth development; Wnt signaling pathway and pluripotency; PTF1A related regulatory pathway; Wnt signaling in kidney disease; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Genes controlling nephrogenesis; GDNF/RET signaling axis; Mammalian disorder of sexual development; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; 1q21.1 copy number variation syndrome; 7q11.23 copy number variation syndrome; Development of ureteric collection system; Malignant pleural mesothelioma; Alzheimer's disease; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response (only ATM dependent)","Deactivation of the beta-catenin transactivating complex; InlA-mediated entry of Listeria monocytogenes into host cells; RHO GTPases activate IQGAPs; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Myogenesis; Transcriptional Regulation by VENTX; Ca2+ pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; Apoptotic cleavage of cell adhesion  proteins; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production","Rap1 signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Leukocyte transendothelial migration; Melanogenesis; Thyroid hormone signaling pathway; Cushing syndrome; Alcoholic liver disease; Alzheimer disease; Pathways of neurodegeneration; Bacterial invasion of epithelial cells; Salmonella infection; Hepatitis C; Human cytomegalovirus infection; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Proteoglycans in cancer; Colorectal cancer; Endometrial cancer; Prostate cancer; Thyroid cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Arrhythmogenic right ventricular cardiomyopathy; Fluid shear stress and atherosclerosis",3423.4,3122.7,3475.1,3738.8,3778,3777.2,0.8873029927395077,-0.17250126039466343,0.01853701587309231,1.7319601781828522,0.14561068404135288,0.83680675792153,994]
["High","P35249","replication factor C subunit 4 [OS=Homo sapiens]",61,19,43,19,363,39.7,8.02,86.27,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC4","ENSG00000163918","Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","Activation of ATR in response to replication stress; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",1930.9,2114.5,1765.2,2032.2,1909.8,1940.2,0.9878276835197716,-0.017668694588653343,0.8349949960691267,0.0783161271344551,0.9084075420520749,0.04171926870813575,7177]
["High","P35250-1","Replication factor C subunit 2 [OS=Homo sapiens]",57,17,59,17,354,39.1,6.44,147.72,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC2","ENSG00000049541","DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Dual Incision in GG-NER; Termination of translesion DNA synthesis; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",2019.1,1616.3,2032,1995.2,2178.1,2034.7,0.9129188144329896,-0.13144152736434048,0.28846550758484757,0.5399061088899455,0.5325936824834452,0.2736039893782105,4229]
["High","P35555","Fibrillin-1 [OS=Homo sapiens]",3,8,10,5,2871,312,4.93,18.2,"","extracellular matrix","extracellular structural activity;other molecular function","","","","","",105.9,107.8,94.7,85.7,78.5,79.1,1.2675709001233046,0.3420664449766052,0.009851432634830687,2.0065006080649255,0.10879771713261387,0.9633802172031894,707]
["High","P35610","sterol O-acyltransferase 1 [OS=Homo sapiens]",13,6,13,6,550,64.7,8.94,16.73,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","other molecular function","SOAT1","ENSG00000057252","Statin inhibition of cholesterol production; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","LDL clearance","Steroid biosynthesis; Cholesterol metabolism",330,454.8,373.8,295.8,287.5,312.2,1.2938023450586265,0.37161723279848297,0.07824791288313378,1.1065272376208308,0.28051409724128035,0.5520453083819516,2178]
["High","P35611-4","Isoform 4 of Alpha-adducin [OS=Homo sapiens]",43,22,80,2,662,73.3,6.16,141.49,"","","","ADD1","","","","",47.9,41.9,47.9,53,39.1,43,1.0192450037009622,0.02750088480927948,0.8596474353144333,0.06567962816556759,0.9217422651654896,0.03539049810485716,7282]
["High","P35813","Protein phosphatase 1A [OS=Homo sapiens]",36,12,35,11,382,42.4,5.36,68.31,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","PPM1A","ENSG00000100614","TGF-beta signaling pathway; MAPK signaling pathway","Downregulation of SMAD2/3:SMAD4 transcriptional activity; Energy dependent regulation of mTOR by LKB1-AMPK","MAPK signaling pathway",1374.2,1520.6,1337.9,1368,1452.5,1480.3,0.984165736607143,-0.02302680447846607,0.7454856955206671,0.12756068543170046,0.8538583410041616,0.06861417477152125,6817]
["High","P36405","ADP-ribosylation factor-like protein 3 [OS=Homo sapiens]",59,9,46,9,182,20.4,7.24,88.28,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","ARL3","ENSG00000138175","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","Trafficking of myristoylated proteins to the cilium","",1199.9,1470.1,1396.6,1294.9,1306.8,1231.3,1.0609444299504305,0.08534909288370102,0.40636953572888584,0.39107885722204877,0.6326886011906562,0.19880998991985027,5015]
["High","P36543","V-type proton ATPase subunit E 1 [OS=Homo sapiens]",54,13,38,13,226,26.1,8,79.95,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V1E1","ENSG00000131100","VEGFA-VEGFR2 signaling pathway; Proximal tubule transport","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",1736.3,1805.9,1901.5,1878.1,1810.7,1831.6,0.9861060792696181,-0.020185243614431303,0.6478749257252387,0.18850882794152418,0.7946288752847415,0.09983565756787309,6366]
["High","P36915-1","Guanine nucleotide-binding protein-like 1 [OS=Homo sapiens]",26,13,33,13,607,68.6,5.8,68.26,"stress response;signal transduction;other biological processes","non-structural extracellular","other molecular function","GNL1","ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986","","","",918.9,1036.4,898.9,870.1,877.6,903.9,{"$f":"AVERAGE(T1858:V1858)/AVERAGE(W1858:Y1858)","v":1.076406697842812},{"$f":"LOG(Z1858,2)","v":0.10622327315762167},{"$f":"TTEST(T1858:V1858,W1858:Y1858,2,2)","v":0.2004153788603009},{"$f":"-LOG10(AB1858)","v":0.6980689559689359},{"$f":"AB1858*7808/AF1858","v":0.4417965212143505},{"$f":"-LOG10(AD1858)","v":0.35477770816435644},3542]
["High","P36955","Pigment epithelium-derived factor [OS=Homo sapiens]",5,2,4,2,418,46.3,6.38,8.18,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other cell component","enzyme regulator activity","SERPINF1","ENSG00000132386","lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Type I collagen synthesis in the context of osteogenesis imperfecta; GPR143 in melanocytes and retinal pigment epithelium cells; Malignant pleural mesothelioma","","Wnt signaling pathway",92.3,68.3,95.1,72.6,92.8,85.1,1.0207584830339322,0.029641557159078246,0.8750431509391281,0.057970530117484174,0.9307092933568605,0.031185949530300364,7341]
["High","P37837","Transaldolase [OS=Homo sapiens]",44,17,161,17,337,37.5,6.81,329.5,"other metabolic processes","cytosol;other cell component","other molecular function","TALDO1","ENSG00000177156","Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of  Fru(6)P, E4P to SH7P, GA3P","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",9139,8420.7,9032.4,9028.6,9062,8986.8,0.982077304320208,-0.02609150398295846,0.511655060684838,0.2910227259899058,0.7039652359166899,0.1524487871964307,5675]
["High","P38159-2","Isoform 2 of RNA-binding motif protein, X chromosome [OS=Homo sapiens]",67,34,266,11,378,40.8,10.04,391.98,"","","","RBMX","","","","",13830.6,15819.9,13266.4,16167.5,15243.1,16476.9,0.8962025580788305,-0.15810325042955292,0.12584400313097704,0.9001674751428616,0.35256188605908456,0.4527646391975304,2787]
["High","P39023","60S ribosomal protein L3 [OS=Homo sapiens]",47,22,295,22,403,46.1,10.18,487.69,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","other molecular function","RPL3","ENSG00000100316","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",11975.1,11303.7,12107.8,11173.9,12157.3,11959.9,1.0027060647018655,0.00389875336220989,0.9388780314571089,0.027390822755877238,0.9668635807988798,0.014634798187657618,7582]
["High","P40123","Adenylyl cyclase-associated protein 2 [OS=Homo sapiens]",32,14,33,13,477,52.8,6.37,71.97,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","cytoskeletal activity;other molecular function","CAP2","ENSG00000112186","Ectoderm differentiation; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway","Role of ABL in ROBO-SLIT signaling","",1322.4,1374.2,1294.9,1442.4,1503.2,1469.9,0.903974634809195,-0.14564580316326106,0.008343550808160806,2.0786490850690957,0.09991785998484597,1.0003568761423807,652]
["High","P40429","60S ribosomal protein L13a [OS=Homo sapiens]",42,12,97,12,203,23.6,10.93,170.49,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","RPL13A","ENSG00000142541","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",4931.2,4407.4,5272.1,4908,5689,5216,0.9239676215771832,-0.11408579845001579,0.30242446281384167,0.5193830821014969,0.5454678229730829,0.2632308632560181,4329]
["High","P40937-1","Replication factor C subunit 5 [OS=Homo sapiens]",68,20,58,20,340,38.5,7.2,116.44,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC5","ENSG00000111445","Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","HDR through Homologous Recombination (HRR); Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Termination of translesion DNA synthesis; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",2583.7,1996.6,2659.7,2662.9,3022,2883.7,0.8449454986812316,-0.2430698083069089,0.13155887595794394,0.8808798457955536,0.3591649312865826,0.4447060742659612,2860]
["Medium","P41217","OX-2 membrane glycoprotein [OS=Homo sapiens]",4,1,1,1,278,31.2,8.51,2.55,"cell adhesion;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CD200","ENSG00000091972","Vitamin D receptor pathway","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","",146.2,116.4,131.6,151.9,170.2,138.5,0.855840208423795,-0.2245866347493598,0.15348680992732083,0.8139289401992431,0.38448027331168466,0.41512593781744755,3117]
["High","P41225","Transcription factor SOX-3 [OS=Homo sapiens]",29,7,13,7,446,45.2,9.77,44.52,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SOX3","ENSG00000134595","","Deactivation of the beta-catenin transactivating complex","",470.4,378,479.4,228.8,249,232.7,1.8688247712878252,0.9021313023920249,3.3664789880818863E-3,2.4728240918416824,0.06199402815788531,1.2076501437757794,424]
["High","P41273","Tumor necrosis factor ligand superfamily member 9 [OS=Homo sapiens]",11,2,2,2,254,26.6,7.02,0,"cell-cell signaling;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding","TNFSF9","ENSG00000125657","Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling","TNFs bind their physiological receptors","Cytokine-cytokine receptor interaction",17.7,22.9,18.5,19.7,15.6,18.9,{"$f":"AVERAGE(T1922:V1922)/AVERAGE(W1922:Y1922)","v":1.0904059040590406},{"$f":"LOG(Z1922,2)","v":0.12486527882366089},{"$f":"TTEST(T1922:V1922,W1922:Y1922,2,2)","v":0.46948672231459654},{"$f":"-LOG10(AB1922)","v":0.32837668562799455},{"$f":"AB1922*7808/AF1922","v":0.6736038823653748},{"$f":"-LOG10(AD1922)","v":0.17159541841309803},5442]
["High","P42167","Lamina-associated polypeptide 2, isoforms beta/gamma [OS=Homo sapiens]",52,19,144,6,454,50.6,9.38,338.34,"","other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","TMPO","ENSG00000120802","Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RHOC GTPase cycle; RHOJ GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle","",2683.7,3406.2,2794.8,3044.2,2987.5,3001.7,0.9835388668718313,-0.02394602973963037,0.8366144874004147,0.07747461914388926,0.9092825609162636,0.04130113814450182,7184]
["High","P42285","Superkiller viralicidic activity 2-like 2 [OS=Homo sapiens]",36,35,115,34,1042,117.7,6.52,206.2,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus","other molecular function","MTREX","ENSG00000039123","","mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol","RNA degradation",4201.6,3888.4,4281.4,4808.7,5147.4,5068.4,0.8234150886884756,-0.28030820928794636,0.004960012251194883,2.304517250804205,0.07505382879327452,1.124627147772781,516]
["High","P42575-1","caspase-2 [OS=Homo sapiens]",3,2,2,2,452,50.7,6.81,6.43,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","CASP2","ENSG00000106144; ENSPPAG00000028627; ENSPTRG00000019805; ENSPTRG00000047033","Apoptosis modulation and signaling; Parkinson's disease pathway; Apoptosis; Apoptosis modulation by HSP70; Acute viral myocarditis; Apoptosis modulation by HSP70","TP53 Regulates Transcription of Caspase Activators and Caspases; NOD1/2 Signaling Pathway; NADE modulates death signalling","Apoptosis",93.3,92.2,85.3,102.3,105.8,102.7,0.8712998712998712,-0.19875876483271354,0.008210601979678161,2.0856250003874663,0.0990855954518193,1.0039894763975312,647]
["High","P42695","condensin-2 complex subunit D3 [OS=Homo sapiens]",14,15,27,15,1498,168.8,7.5,41.1,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","other molecular function","NCAPD3","ENSG00000151503","","Condensation of Prophase Chromosomes","",1129,865,1048.6,1131.8,1106.4,1126.5,0.9042708116622581,-0.1451731982060136,0.24324881084538658,0.6139492741615594,0.49178837780444806,0.30822173894629995,3862]
["High","P42858","huntingtin [OS=Homo sapiens]",13,33,62,33,3142,347.4,6.2,114.75,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","HTT","ENSG00000197386","Mesodermal commitment pathway; Mesodermal commitment pathway; ERK pathway in Huntington's disease; Rett syndrome causing genes","Regulation of MECP2 expression and activity","Huntington disease; Pathways of neurodegeneration",2373.6,2259.8,2387.9,2503.4,2535.7,2555.3,0.9245365005793741,-0.11319781672317007,0.011547210694292688,1.937522909830167,0.11588768779053639,0.9359627021612206,778]
["High","P43155","Carnitine O-acetyltransferase [OS=Homo sapiens]",8,4,5,4,626,70.8,8.44,10.23,"other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","CRAT","ENSG00000095321","Fatty acid beta-oxidation","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","",211.7,217,214,227.3,234.4,238.1,0.9184052586453273,-0.12279719220323075,0.005669247266641038,2.2464746006566094,0.08019109177161816,1.0958738737271727,552]
["High","P43304","Glycerol-3-phosphate dehydrogenase, mitochondrial [OS=Homo sapiens]",44,25,80,25,727,80.8,7.69,158.64,"other metabolic processes","other membranes;mitochondrion;other cell component","other molecular function","GPD2","ENSG00000115159","Fatty acid beta-oxidation","Triglyceride catabolism; Synthesis of PA","Glycerophospholipid metabolism",3085.2,2696.9,3318.3,3310.2,3733,3494.6,0.8635958169636928,-0.21157183955421582,0.09359442172486734,1.0287500346625542,0.3056400020191402,0.5147898061196937,2391]
["High","P45880","Voltage-dependent anion-selective channel protein 2 [OS=Homo sapiens]",68,16,150,15,294,31.5,7.56,373.23,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","VDAC2","ENSG00000165637","Alzheimer's disease and miRNA effects; Ferroptosis; Alzheimer's disease","Ub-specific processing proteases; Mitochondrial calcium ion transport","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy",5971.7,5439.1,6364.7,5318.8,6225.2,5881.1,1.02010892333473,0.028723205887928274,0.7718573326938228,0.1124629656612378,0.8704017986241145,0.06028022020595866,6924]
["High","P45984-1","Mitogen-activated protein kinase 9 [OS=Homo sapiens]",10,5,14,4,424,48.1,5.63,22.71,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","MAPK9","ENSG00000050748; ENSGGOG00000016519; ENSOCUG00000015542; ENSPPAG00000038007; ENSPTRG00000017633","IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Wnt signaling pathway and pluripotency; Splicing factor NOVA regulated synaptic proteins; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; CCL18 signaling pathway; Familial partial lipodystrophy (FPLD); Alzheimer's disease; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway; MAPK signaling pathway; Wnt signaling pathway","Oxidative Stress Induced Senescence; FCERI mediated MAPK activation; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors","Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; cAMP signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Mitophagy; Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Apoptosis; Necroptosis; Wnt signaling pathway; Osteoclast differentiation; Focal adhesion; Tight junction; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; Insulin signaling pathway; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Adipocytokine signaling pathway; Relaxin signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Measles; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Choline metabolism in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",404.2,223.3,383.7,360.7,346.6,333.8,0.9712803765248296,-0.04204028077352045,0.8712838352451141,0.059840343269919834,0.92911556754901,0.03193026315679666,7322]
["High","P46087-2","Isoform 2 of Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase [OS=Homo sapiens]",44,30,141,30,808,88.9,9.23,295.98,"","","","NOP2","","","","",6241.8,6431,5782.7,5515.3,5272.3,5603.1,1.1259738754293593,0.17117335474874656,0.03352592694035898,1.4746192057353418,0.18657907166808477,0.7291370721050662,1403]
["High","P46736","Lys-63-specific deubiquitinase BRCC36 [OS=Homo sapiens]",27,8,23,8,316,36,5.92,53.29,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","BRCC3","ENSG00000185515","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","Homologous recombination; NOD-like receptor signaling pathway",832.7,620.5,724.3,743,742.3,745.2,0.9762385115444968,-0.03469442928734782,0.7874028062990517,0.10380304172000708,0.8810606350792485,0.0549942021734637,6978]
["High","P46777","60S ribosomal protein L5 [OS=Homo sapiens]",64,20,329,20,297,34.3,9.72,573.24,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL5","ENSG00000122406","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",16140.2,17703.2,15976.1,15888.1,16224.6,16035.1,1.0347201741304897,0.049240663398652844,0.3752166592209766,0.4257178876513761,0.6066870315173711,0.21703528839308706,4829]
["High","P46934-4","Isoform 4 of E3 ubiquitin-protein ligase NEDD4 [OS=Homo sapiens]",6,5,7,3,900,104.2,5.97,7.19,"","","","NEDD4","","","","",14.7,11.9,11.8,16.3,8.2,11.8,1.0578512396694217,0.08113676272540583,0.7956173030919389,0.09929578040477381,0.8861882885223764,0.05247399371279709,7010]
["High","P47895","Aldehyde dehydrogenase family 1 member A3 [OS=Homo sapiens]",20,11,19,8,512,56.1,7.25,35.56,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","ALDH1A3","ENSG00000184254","Ethanol effects on histone modifications; Vitamin A and carotenoid metabolism","RA biosynthesis pathway","Retinol metabolism; Metabolic pathways",565.8,565.3,589.1,608.3,593,576.1,0.9678181613592888,-0.04719208287130414,0.19226111193790998,0.7161085502841013,0.4326152051905479,0.36389822041633957,3470]
["High","P47897","glutamine--tRNA ligase [OS=Homo sapiens]",51,38,153,37,775,87.7,7.15,333.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;mitochondrion;other cell component","enzyme regulator activity;other molecular function","QARS1","ENSG00000172053","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis; Metabolic pathways",6655.8,7537.7,6621.7,5576.2,5933.5,5954,1.1919123667951237,0.25327816815101983,0.026083949238259428,1.5836266536403667,0.16776233579269326,0.7753055357209702,1214]
["High","P48200","iron-responsive element-binding protein 2 [OS=Homo sapiens]",4,4,4,4,963,105,7.05,6.34,"","","","","","","","",164.7,204.5,145,130.6,118.2,135.5,1.338017174082748,0.42009663377085343,0.07650965185609522,1.1162837742132818,0.27824283264666577,0.5555760139908953,2147]
["High","P48444","Coatomer subunit delta [OS=Homo sapiens]",49,22,104,22,511,57.2,6.21,174.94,"transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","","ARCN1","ENSG00000095139","miR-517 relationship with ARCN1 and USP1","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",4631.5,3882.8,4833.1,4587.6,5061.1,4815.7,0.9227759188075549,-0.11594773962051372,0.30900155747900193,0.510039331569238,0.5522280065909927,0.25788157162017106,4369]
["High","P48553","Trafficking protein particle complex subunit 10 [OS=Homo sapiens]",3,3,4,3,1259,142.1,6.04,10.65,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC10","ENSG00000160218","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",104.2,109.7,125.8,111,125,114,0.9705714285714285,-0.04309370384049035,0.6807840548247284,0.16699062475473997,0.8151452078011775,0.08876502030356417,6521]
["High","P48681","Nestin [OS=Homo sapiens]",55,73,259,73,1621,177.3,4.36,559.8,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;other molecular function","NES","ENSG00000132688","","","",12197.3,10560.5,10927.3,12483.3,9682.2,10028.2,1.0463258339364534,0.06533218791713126,0.6488650237748526,0.1878456352894971,0.7950938646632217,0.09958159775995558,6372]
["High","P49023","Paxillin [OS=Homo sapiens]",32,12,31,12,591,64.5,6.19,52.07,"cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PXN","ENSG00000089159","Integrin-mediated cell adhesion; Prolactin signaling pathway; Oncostatin M signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; 3q29 copy number variation syndrome; Regulation of actin cytoskeleton","VEGFA-VEGFR2 Pathway; GAB1 signalosome; Smooth Muscle Contraction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","Chemokine signaling pathway; VEGF signaling pathway; Focal adhesion; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Human papillomavirus infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis; Proteoglycans in cancer",1290.7,1336.9,1209.4,1176.3,1054.9,1102.7,1.150904346261136,0.20276793346213023,0.030887880297005597,1.5102118944470309,0.18024855706952145,0.7441282032201997,1338]
["High","P49069","calcium signal-modulating cyclophilin ligand [OS=Homo sapiens]",22,5,9,5,296,32.9,8.05,27.55,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","CAMLG","ENSG00000164615","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",331.3,377.1,350.6,303.7,297.4,302,1.17262761598937,0.2297449384645969,0.017906719109045528,1.7469839788278392,0.14296080041250253,0.8447830289568051,978]
["High","P49327","Fatty acid synthase [OS=Homo sapiens]",60,115,750,114,2511,273.3,6.44,1825.21,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","FASN","ENSG00000169710","AMP-activated protein kinase (AMPK) signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway","ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism","Fatty acid biosynthesis; Metabolic pathways; Fatty acid metabolism; AMPK signaling pathway; Insulin signaling pathway; Alcoholic liver disease",31152.7,30897.8,31933.2,28370.4,30789.1,29945.9,1.054747523719101,0.07689770047751386,0.10361737669040627,0.9845674070624336,0.32041365433611574,0.4942889848584784,2525]
["High","P49406","39S ribosomal protein L19, mitochondrial [OS=Homo sapiens]",35,10,18,9,292,33.5,9.5,36.57,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPL19","ENSG00000115364","Cytoplasmic ribosomal proteins","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",829.8,725.3,919.1,861.4,1063.3,958.5,0.8581437291897891,-0.22070879212363345,0.16697976562210162,0.7773361528708832,0.403271886785453,0.39440205282380386,3233]
["High","P49441","Inositol polyphosphate 1-phosphatase [OS=Homo sapiens]",14,3,4,3,399,44,5.26,7.09,"other metabolic processes;signal transduction","cytosol","other molecular function","INPP1","ENSG00000151689","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",33.2,30.2,28.4,31.9,36.1,34.2,0.898238747553816,-0.15482913752381336,0.134735618935025,0.8705175782782553,0.36326509414526076,0.4397763311447292,2896]
["High","P49591","Serine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",47,24,116,24,514,58.7,6.43,211.34,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SARS1","ENSG00000031698","VEGFA-VEGFR2 signaling pathway","Cytosolic tRNA aminoacylation; Selenocysteine synthesis","Aminoacyl-tRNA biosynthesis",4137.8,3465.2,4052.7,4079.7,4143.2,4083.8,0.9471019850975485,-0.07840830966630849,0.36478756928525763,0.437959969364456,0.5983742312981705,0.22302711742631376,4760]
["High","P49736","DNA replication licensing factor mcm2 [OS=Homo sapiens]",58,46,213,46,904,101.8,5.52,476.82,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM2","ENSG00000073111","Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","DNA replication; Cell cycle",7618,7609.1,7800.2,7822.6,8441.5,8269.4,0.9386063953369882,-0.09140780446629124,0.06138132385753169,1.2119637490449477,0.2469167319317916,0.6074494797746752,1941]
["High","P49756-1","RNA-binding protein 25 [OS=Homo sapiens]",39,36,103,36,843,100.1,6.32,213.46,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RBM25","ENSG00000119707; ENSGGOG00000002415; ENSPPAG00000039402; ENSPTRG00000006509","","","Spliceosome",5437.3,5961.4,5017.3,5236.7,5087.4,5218.9,1.0561667631731328,0.07883764663581776,0.3529301463196987,0.4523112438187743,0.5899547382710785,0.22918130644792165,4671]
["High","P49773","Histidine triad nucleotide-binding protein 1 [OS=Homo sapiens]",40,5,14,5,126,13.8,6.95,36.19,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","HINT1","ENSG00000169567","","","",1015,1150.1,987.8,1045.1,977,953.3,1.0596558445923236,0.08359578184528396,0.3596345974868153,0.44413853502877365,0.5951731532804269,0.2253566669197149,4718]
["High","P49840","Glycogen synthase kinase-3 alpha [OS=Homo sapiens]",30,8,17,6,483,50.9,8.75,34.2,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","GSK3A","ENSG00000105723","IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation","XBP1(S) activates chaperone genes; Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein","Chemokine signaling pathway; Dopaminergic synapse; Non-alcoholic fatty liver disease; Shigellosis",279,246.5,286.9,281.8,313.8,288.2,0.9192124915139174,-0.12152969146085218,0.2055341927500677,0.6871159183747533,0.44814604216490606,0.3485804347280208,3581]
["High","P49915","GMP synthase [glutamine-hydrolyzing] [OS=Homo sapiens]",73,43,195,43,693,76.7,6.87,428.98,"other metabolic processes","cytosol","other molecular function","GMPS","ENSG00000163655","","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Drug metabolism; Metabolic pathways",7897.1,7492.7,8019.6,8352.5,9077.2,8701.7,0.8958341305861913,-0.15869646208354263,0.026031515237559665,1.584500551823209,0.1678398604251576,0.7751048903076257,1211]
["High","P50148","Guanine nucleotide-binding protein G(Q) subunit alpha [OS=Homo sapiens]",12,5,10,4,359,42.1,5.68,22.41,"cell-cell signaling;stress response;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","GNAQ","ENSG00000156052","Thyroid stimulating hormone (TSH) signaling pathway; Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Circadian rhythm genes; Cell-type dependent selectivity of CCK2R signaling; Hippo signaling regulation pathways; Gastrin signaling pathway; PKC-gamma calcium signaling pathway in ataxia; GPR143 in melanocytes and retinal pigment epithelium cells; Airway smooth muscle cell contraction; Prostaglandin and leukotriene metabolism in senescence ; Alzheimer's disease; Calcium regulation in cardiac cells; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 2 and STAT3 signaling","G alpha (q) signalling events; Thrombin signalling through proteinase activated receptors (PARs); G-protein activation; ADP signalling through P2Y purinoceptor 1; Thromboxane signalling through TP receptor; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Apelin signaling pathway; Gap junction; Platelet activation; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Yersinia infection; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",243.2,236.6,297,277.3,326,283.7,0.87576099210823,-0.19139090376923396,0.20788724608692163,0.6821721538815032,0.44988459463599895,0.34689887809277187,3608]
["High","P50395-1","Rab GDP dissociation inhibitor beta [OS=Homo sapiens]",74,32,218,24,445,50.6,6.47,449.1,"transport;signal transduction","non-structural extracellular;other membranes;cytosol;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","GDI2","ENSG00000057608; ENSNLEG00000035201","","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs","",9167.7,8874.5,9551.1,9106.4,10169.9,9595.9,0.9557047956165449,-0.06536303700469083,0.3070648954502667,0.5127698305242795,0.5504046610825717,0.25931789694938145,4356]
["High","P50479-1","PDZ and LIM domain protein 4 [OS=Homo sapiens]",3,1,1,1,330,35.4,7.91,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","PDLIM4","ENSG00000131435; ENSPTRG00000017214","","","",114.5,109.5,103.5,101.4,102.6,110.7,1.0406736574515414,0.05751772801375153,0.37898906218437683,0.4213733238090137,0.6095049634470885,0.21502275339440194,4855]
["High","P50552","Vasodilator-stimulated phosphoprotein [OS=Homo sapiens]",57,16,65,16,380,39.8,8.94,143.39,"cell organization and biogenesis;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","VASP","ENSG00000125753","Integrin-mediated cell adhesion; Focal adhesion","Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions","Rap1 signaling pathway; cGMP-PKG signaling pathway; Focal adhesion; Tight junction; Platelet activation; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration",2320.7,2598.2,2224.5,2182.5,2102.9,2065.9,1.1247146253522902,0.16955899182792392,0.08735546766697522,1.0587099068999275,0.2947586393879613,0.5305334568570229,2314]
["High","P50851-1","Lipopolysaccharide-responsive and beige-like anchor protein [OS=Homo sapiens]",19,35,60,1,2863,318.9,5.6,118.25,"other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","LRBA","ENSG00000198589","","","",2225.8,2161.8,2167.3,2142.3,2141.1,2116.9,1.0241551177288566,0.034434241343747306,0.07996804660357036,1.0970835124565608,0.2821466370902293,0.5495251217251833,2213]
["High","P50991","T-complex protein 1 subunit delta [OS=Homo sapiens]",71,31,355,31,539,57.9,7.83,816.82,"transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CCT4","ENSG00000115484","16p11.2 proximal deletion syndrome","Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; Folding of actin by CCT/TriC","",12730.8,11333.6,12965.7,12586.8,13789.3,13242.7,0.9346598079699537,-0.0974867380816503,0.23432572704958268,0.6301800268008666,0.48021398341289806,0.31856519781785053,3810]
["High","P51148","Ras-related protein Rab-5C [OS=Homo sapiens]",74,11,46,9,216,23.5,8.41,119.88,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","RAB5C","ENSG00000108774","Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells","Clathrin-mediated endocytosis; Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Golgi Associated Vesicle Biogenesis; TBC/RABGAPs","Ras signaling pathway; Endocytosis; Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection; Amoebiasis; Tuberculosis",1249.7,1356,1423.9,1207,1423,1317.7,1.0207462573143857,0.02962427776255012,0.7511706899660993,0.1242613662082996,0.8573513736669058,0.06684115197421384,6841]
["High","P51511","Matrix metalloproteinase-15 [OS=Homo sapiens]",7,3,4,3,669,75.8,7.46,11.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes","enzyme regulator activity;other molecular function","MMP15","ENSG00000102996","Matrix metalloproteinases; Epithelial to mesenchymal transition in colorectal cancer","Collagen degradation; Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action",199.8,156.3,198,216.2,221.6,220.2,0.8420972644376901,-0.24794121691900933,0.07263038299073625,1.138881665733623,0.269405240091054,0.5695939612466746,2105]
["Medium","P51512-1","Matrix metalloproteinase-16 [OS=Homo sapiens]",1,1,1,1,607,69.5,8.54,2,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","MMP16","ENSCANG00000029811; ENSCATG00000039014; ENSCSAG00000012941; ENSG00000156103; ENSGGOG00000027756; ENSMFAG00000040046; ENSMMUG00000013193; ENSMNEG00000003965; ENSPANG00000010068; ENSRBIG00000031261; ENSRROG00000034264","Matrix metalloproteinases","Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action; MicroRNAs in cancer",86.6,92.3,77.8,80,68,78.3,1.134334953601414,0.18184671130852584,0.14696011354499347,0.8328005211555343,0.37832659629387044,0.4221331268075624,3033]
["High","P51648","Fatty aldehyde dehydrogenase [OS=Homo sapiens]",24,11,36,11,485,54.8,7.88,85.84,"other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ALDH3A2","ENSG00000072210","Fragile X syndrome; Tryptophan metabolism; Fluoroacetic acid toxicity","RND2 GTPase cycle; RND1 GTPase cycle","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease",1551.3,1251.9,1519.5,1524.5,1652.8,1604,0.904084663166921,-0.1454702144904536,0.20847111965162599,0.6809541010963679,0.4505238035538045,0.3462822580057548,3613]
["High","P51688","N-sulphoglucosamine sulphohydrolase [OS=Homo sapiens]",12,4,8,4,502,56.7,6.95,19.39,"protein metabolism;other metabolic processes","other cytoplasmic organelle","other molecular function","SGSH","ENSG00000181523","Glycosaminoglycan degradation","HS-GAG degradation; MPS IIIA - Sanfilippo syndrome A","Glycosaminoglycan degradation; Metabolic pathways; Lysosome",176.2,197.5,183.4,157.6,160,161.1,1.1637768957593482,0.2188145099368106,0.014590242343888785,1.835937494416382,0.12960251674753542,0.8873865648315185,879]
["High","P51797-1","Chloride transport protein 6 [OS=Homo sapiens]",4,2,2,2,869,97.2,6.81,5.36,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","CLCN6","ENSG00000011021","","Signaling by BRAF and RAF1 fusions; Stimuli-sensing channels","",23.6,31.3,25.5,31.1,30.3,24.9,0.9316338354577056,-0.1021650580000265,0.5511338110776016,0.25874294496436256,0.7301073628934364,0.13661327181963348,5894]
["Medium","P51825","AF4/FMR2 family member 1 [OS=Homo sapiens]",1,1,1,1,1210,131.3,9.2,2.1,"other biological processes","nucleus","","AFF1","ENSG00000172493","","","Transcriptional misregulation in cancer",69,53,64.9,66.1,77.4,89.2,0.8031800601633005,-0.3162046416601904,0.13668025679660076,0.8642942139145251,0.3654792620095407,0.437137260704308,2920]
["High","P51948-1","CDK-activating kinase assembly factor MAT1 [OS=Homo sapiens]",28,6,12,6,309,35.8,6.09,32.73,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","enzyme regulator activity;kinase activity;other molecular function","MNAT1","ENSCANG00000033478; ENSCATG00000030975; ENSCSAG00000014164; ENSG00000020426; ENSMFAG00000000901; ENSMMUG00000001642; ENSNLEG00000013781; ENSPPAG00000033622; ENSPTRG00000006412; ENSRROG00000035712","Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; Eukaryotic transcription initiation; G1 to S cell cycle control","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin D associated events in G1; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Basal transcription factors; Nucleotide excision repair",399.6,342.4,423.5,419.6,413.7,413.9,0.9344932649134061,-0.09774382868155598,0.3223091578238859,0.49172735463077116,0.5640049090741599,0.24871711591995466,4462]
["High","P51991-1","Heterogeneous nuclear ribonucleoprotein A3 [OS=Homo sapiens]",52,24,241,22,378,39.6,9.01,505.27,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","transporter activity;nucleic acid binding activity","HNRNPA3; HNRPA3","ENSG00000170144; ENSGGOG00000006130; ENSHGLG00000005451; ENSPPAG00000023768; ENSPTRG00000012676; ENSSTOG00000025125","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Spliceosome; Amyotrophic lateral sclerosis",10144.4,14037.3,10465.5,11188.2,11300.1,11533.5,1.0183823313287361,0.026279294181506867,0.8758069341550214,0.05759162062671941,0.9306342599186727,0.031220963601854758,7348]
["High","P52306-1","Rap1 GTPase-GDP dissociation stimulator 1 [OS=Homo sapiens]",27,11,23,11,607,66.3,5.31,47.1,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;ER/Golgi","enzyme regulator activity","RAP1GDS1","ENSG00000138698","","RHOT2 GTPase cycle; RHOT1 GTPase cycle","",974.1,854.5,1064.9,1022.7,990.1,1008.9,0.9575735513121751,-0.06254479005553154,0.5263833708220444,0.2786978391401103,0.7137897463318033,0.1464296950235381,5758]
["High","P52597","Heterogeneous nuclear ribonucleoprotein F [OS=Homo sapiens]",66,18,246,16,415,45.6,5.58,405.27,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPF","ENSG00000169813","MECP2 and associated Rett syndrome","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",6139.9,6672.4,5968.3,5880.9,5800.1,5808.3,1.0738337154717457,0.1027706074410384,0.11402899524121525,0.9429847024168492,0.3362305116478129,0.4733628785258761,2648]
["High","P52739","Zinc finger protein 131 [OS=Homo sapiens]",23,9,13,9,623,71.4,5.19,20.41,"other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","ZNF131","ENSG00000172262","","SUMOylation of transcription cofactors","",282.5,229.9,269.2,258,288.5,255.2,0.9749282774105025,-0.03663200692790995,0.7428582643470547,0.12909404072645997,0.8533525567194061,0.06887150599008625,6797]
["High","P52789","Hexokinase-2 [OS=Homo sapiens]",46,37,122,34,917,102.3,6.05,291.02,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component","kinase activity;other molecular function","HK2","ENSG00000159399","Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis","Glycolysis","Glycolysis / Gluconeogenesis; Fructose and mannose metabolism; Galactose metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Neomycin, kanamycin and gentamicin biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of nucleotide sugars; HIF-1 signaling pathway; Insulin signaling pathway; Type II diabetes mellitus; Carbohydrate digestion and absorption; Shigellosis; Central carbon metabolism in cancer",4622.8,5114.3,4680.9,4419.6,4448.5,4637.6,{"$f":"AVERAGE(T2242:V2242)/AVERAGE(W2242:Y2242)","v":1.067549256980386},{"$f":"LOG(Z2242,2)","v":0.09430263767890792},{"$f":"TTEST(T2242:V2242,W2242:Y2242,2,2)","v":0.14717370371595603},{"$f":"-LOG10(AB2242)","v":0.8321697807000064},{"$f":"AB2242*7808/AF2242","v":0.3783774378051316},{"$f":"-LOG10(AD2242)","v":0.42207476795963617},3037]
["High","P52907","F-actin-capping protein subunit alpha-1 [OS=Homo sapiens]",67,13,143,11,286,32.9,5.69,385.37,"cell organization and biogenesis","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity","CAPZA1","ENSG00000116489","","MHC class II antigen presentation; Advanced glycosylation endproduct receptor signaling; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production","Endocytosis",4625.5,5424,4882.6,4934.7,4950,5110.2,0.9958119093825234,-6.0548255123570776E-3,0.9352053818129394,0.02909300261082598,0.9660118562237638,0.015017543293659504,7559]
["High","P53367","Arfaptin-1 [OS=Homo sapiens]",54,16,45,1,373,41.7,6.7,91.35,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","ARFIP1","ENSG00000164144","","","",1591.6,1256,1584.6,1469.7,1349.3,1384.4,1.0544321263738878,0.07646623207298968,0.5479257226791727,0.26127831088961795,0.7278332838855021,0.13796808796757626,5878]
["High","P53611","Geranylgeranyl transferase type-2 subunit beta [OS=Homo sapiens]",20,7,20,7,331,36.9,5.03,29.64,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RABGGTB","ENSG00000137955","","RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain","",621.5,502.8,619.8,506.2,584.6,537.4,1.071182901363469,0.0992048371014023,0.44289895333345425,0.35369534604633707,0.6548295829630014,0.1838717088761965,5281]
["High","P53667-1","LIM domain kinase 1 [OS=Homo sapiens]",8,3,6,3,647,72.5,6.98,12.9,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","LIMK1","ENSG00000106683; ENSPTRG00000019286; ENSPTRG00000045946","Microtubule cytoskeleton regulation; VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; G13 signaling pathway","Regulation of actin dynamics for phagocytic cup formation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Axon guidance; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Human immunodeficiency virus 1 infection",238.5,123.5,219.2,197.9,209.7,212.2,0.9377218457566958,-0.09276805195337429,0.7376594602522341,0.13214408352350687,0.8503831486268187,0.07038535447123273,6773]
["High","P53778","Mitogen-activated protein kinase 12 [OS=Homo sapiens]",10,3,3,3,367,41.9,6.39,4.87,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","MAPK12","ENSG00000188130","Integrin-mediated cell adhesion; Parkinson's disease pathway; S1P receptor signal transduction; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway","p38MAPK events; Negative regulation of MAPK pathway; VEGFA-VEGFR2 Pathway; Myogenesis; NOD1/2 Signaling Pathway; DSCAM interactions; Activation of PPARGC1A (PGC-1alpha) by phosphorylation","Endocrine resistance; MAPK signaling pathway; Rap1 signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; VEGF signaling pathway; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Leukocyte transendothelial migration; Thermogenesis; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Relaxin signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Proteoglycans in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",65.9,85.1,60.2,65.3,61.3,65.2,1.1011470281543272,0.1390071143403223,0.4453253740079218,0.35132255868042717,0.656428265103616,0.18281272695738945,5297]
["High","P53985","Monocarboxylate transporter 1 [OS=Homo sapiens]",15,13,93,13,500,53.9,8.66,223.41,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;other molecular function","SLC16A1","ENSG00000155380; ENSG00000281917","Photodynamic therapy-induced HIF-1 survival signaling; Fragile X syndrome","Basigin interactions; Pyruvate metabolism; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)","",6085.7,8920.2,6712,6582.2,6018.1,6510.3,1.1364321371385515,0.18451153515720367,0.3781591872856691,0.422325344060676,0.6090484600508466,0.21534815056027043,4848]
["High","P54252","Ataxin-3 [OS=Homo sapiens]",12,3,5,3,364,41.8,4.91,7.43,"","","","","","","","",133.2,103.4,135.7,162.5,166.1,150.9,0.7764337851929091,-0.36506519905398077,0.034509970910818664,1.4620554067843248,0.1882975911052915,0.7251552358854658,1431]
["High","P54578","Ubiquitin carboxyl-terminal hydrolase 14 [OS=Homo sapiens]",51,21,101,21,494,56,5.3,239.24,"protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","USP14","ENSG00000101557","","Ub-specific processing proteases","",4350.9,3374.1,4118.3,3930.9,3761.5,3838.1,1.0271280516889987,0.03861605314638174,0.7445828894054334,0.12808694813667668,0.8539517039479471,0.06856669055457275,6808]
["High","P54687","Branched-chain-amino-acid aminotransferase, cytosolic [OS=Homo sapiens]",47,16,148,2,386,42.9,5.3,289.85,"cell cycle OR cell proliferation;other metabolic processes","cytosol;mitochondrion","other molecular function","BCAT1","ENSG00000060982","Amino acid metabolism; One-carbon metabolism and related pathways","Branched-chain amino acid catabolism","Cysteine and methionine metabolism; Valine, leucine and isoleucine degradation; Valine, leucine and isoleucine biosynthesis; Pantothenate and CoA biosynthesis; Metabolic pathways; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors",5967.6,6448.8,5903.4,6000.2,5954,6058.4,1.0170547283568172,0.0243973136148753,0.5893202678475815,0.22964862243276443,0.7573095212893214,0.12072658296487773,6076]
["High","P54764","Ephrin type-A receptor 4 [OS=Homo sapiens]",5,3,3,3,986,109.8,6.61,10.23,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","EPHA4","ENSG00000116106","Spinal cord injury; Gene regulatory network modelling somitogenesis ; Fragile X syndrome; Somitogenesis in the context of spondylocostal dysostosis","EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse","Axon guidance",101.5,132.8,105.6,106.2,126.4,119.7,0.9648027249503264,-0.05169411295329198,0.7369809680329522,0.13254372731732914,0.8502286345155572,0.07046427268966084,6768]
["High","P54920","alpha-soluble nsf attachment protein [OS=Homo sapiens]",59,15,77,15,295,33.2,5.36,211.67,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","NAPA","ENSG00000105402","Synaptic vesicle pathway; VEGFA-VEGFR2 signaling pathway","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network; COPI-dependent Golgi-to-ER retrograde traffic; Intra-Golgi traffic","Synaptic vesicle cycle",2676.8,2058.7,2697.2,2551.9,2687,2673.1,0.9394211324570272,-0.09015604722732372,0.49655478938334885,0.30403282488448474,0.6941987100277865,0.1585161976774772,5585]
["High","P55061","Bax inhibitor 1 [OS=Homo sapiens]",3,1,2,1,237,26.5,8.54,4.76,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","TMBIM6","ENSG00000139644","","","Pathogenic Escherichia coli infection",189.5,131.9,217.7,98.8,115.5,100.9,1.710342639593908,0.7742853747747213,0.044383252577381335,1.3527808741488985,0.21015429722510215,0.677461725134782,1649]
["High","P55145","Mesencephalic astrocyte-derived neurotrophic factor [OS=Homo sapiens]",19,4,7,4,182,20.7,8.69,13.77,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","MANF","ENSG00000145050","Orexin receptor pathway","Platelet degranulation","",233.6,224.9,306.5,353.3,278.9,272.8,0.8453038674033149,-0.24245804439055368,0.27122821857685925,0.5666651284676545,0.5176607016983908,0.28595480330739287,4091]
["High","P55265-1","Double-stranded RNA-specific adenosine deaminase [OS=Homo sapiens]",49,54,263,54,1226,136,8.65,499.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ADAR","ENSG00000160710","Measles virus infection; Cytosolic DNA-sensing pathway","Interferon alpha/beta signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins","Cytosolic DNA-sensing pathway; Measles; Influenza A; Coronavirus disease",12902.9,13123,13031.7,13820.6,14198.2,14318.5,0.9225340302759034,-0.11632596484737456,2.5729037945033373E-3,2.58957645253721,0.05503899404789605,1.2593295123350492,365]
["High","P55786","puromycin-sensitive aminopeptidase [OS=Homo sapiens]",50,37,153,37,919,103.2,5.72,323.71,"protein metabolism;other metabolic processes;stress response","cytosol;nucleus;other cell component","other molecular function","NPEPPS","ENSG00000141279","","Antigen processing: Ubiquitination & Proteasome degradation","",6427.9,6348.6,6467.8,6799.8,7042.9,6932.3,0.9263200962695547,-0.11041728206902528,2.8930101556242337E-3,2.5386500418017843,0.05882453983102608,1.2304414615106796,384]
["High","P55854","Small ubiquitin-related modifier 3 [OS=Homo sapiens]",20,2,6,1,103,11.6,5.49,17.4,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SUMO3","ENSG00000184900","Exercise-induced circadian regulation","SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; SUMOylation of immune response proteins; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed","Nucleocytoplasmic transport; Fluid shear stress and atherosclerosis",480,422.6,409.5,415.1,349.9,413.1,1.113742466683643,0.1554156734397622,0.21625961704324378,0.6650245704021331,0.45884649181349113,0.33833258441701547,3680]
["High","P56270-2","Isoform 2 of Myc-associated zinc finger protein [OS=Homo sapiens]",14,7,19,5,493,51,9.1,47.84,"","","","MAZ","","","","",650.1,806.2,658.6,764.4,772.1,862.9,0.8814286905059597,-0.18208423778073557,0.1875838661584814,0.7268045174476754,0.427386876850138,0.36917881721890683,3427]
["High","P56747","Claudin-6 [OS=Homo sapiens]",25,5,20,5,220,23.3,8,42.93,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CLDN6","ENSG00000184697","Epithelial to mesenchymal transition in colorectal cancer","Tight junction interactions","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Pathogenic Escherichia coli infection; Hepatitis C",798.3,778,893.8,664.2,636.2,692.3,1.2395744467305665,0.3098449198342242,0.015357773355640623,1.8136717458576725,0.1332372159564911,0.875374450638362,900]
["High","P57060","RWD domain-containing protein 2B [OS=Homo sapiens]",5,1,1,1,319,36.3,5.87,4.78,"","","","RWDD2B","ENSG00000156253","","","",69,49.8,72.7,53.4,59.8,66.5,{"$f":"AVERAGE(T2370:V2370)/AVERAGE(W2370:Y2370)","v":1.065664997217585},{"$f":"LOG(Z2370,2)","v":0.09175398330237763},{"$f":"TTEST(T2370:V2370,W2370:Y2370,2,2)","v":0.6503882561690426},{"$f":"-LOG10(AB2370)","v":0.18682730924521196},{"$f":"AB2370*7808/AF2370","v":0.7958363115762239},{"$f":"-LOG10(AD2370)","v":0.09917624920896798},6381]
["High","P57081-1","tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 [OS=Homo sapiens]",10,2,2,2,412,45.5,7.11,3.57,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","","WDR4","ENSG00000160193","","tRNA modification in the nucleus and cytosol","",17.5,24.2,17.2,23.2,20.8,22.7,0.8830584707646177,-0.1794191273541242,0.3394318343154364,0.46924742890348176,0.5799308013861986,0.23662382431469656,4570]
["High","P57772","selenocysteine-specific elongation factor [OS=Homo sapiens]",9,5,17,5,596,65.3,8.35,38.67,"protein metabolism;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EEFSEC","ENSG00000132394; ENSG00000284869","","Selenocysteine synthesis","",1681.1,1494,1677.1,1401.3,1404.4,1386.9,1.1573248103801934,0.21079382257894516,0.023812795387542766,1.6231896197095788,0.16014668939356927,0.7954820347895171,1161]
["High","P58107","epiplakin [OS=Homo sapiens]",32,43,92,40,5090,555.3,5.6,194.31,"","","","","","","","",2907.8,2855,2922.6,2157.3,2117.2,2129.1,1.3563308139171715,0.43970909985322587,5.6319884865608091E-6,5.249338241690557,0.0109936415257667,1.958858428359884,4]
["High","P60033","CD81 antigen [OS=Homo sapiens]",18,2,18,2,236,25.8,5.29,45.32,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","CD81","ENSG00000110651","B cell receptor signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; IL-18 signaling pathway; 16p11.2 distal deletion syndrome","Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","B cell receptor signaling pathway; Malaria; Hepatitis C",540.2,668.2,585.9,429.5,414.1,447.5,1.389745178529936,0.4748203769249625,0.012281054121438428,1.9107643547358744,0.12001310460599655,0.9207713293912303,799]
["High","P60660","Myosin light polypeptide 6 [OS=Homo sapiens]",39,6,24,5,151,16.9,4.65,59.47,"developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL6","ENSG00000092841","Ciliary landscape","Smooth Muscle Contraction; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; RHO GTPases activate PKNs","Vascular smooth muscle contraction; Tight junction; Oxytocin signaling pathway",739.5,1985.7,753.7,827.5,755.1,729,1.5049749091538327,0.5897394346653198,0.40061164853318876,0.39727642693426224,0.6276034814901962,0.20231465592674008,4984]
["High","P60763","Ras-related C3 botulinum toxin substrate 3 [OS=Homo sapiens]",26,5,33,1,192,21.4,8.15,80.24,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","RAC3","ENSG00000169750","Integrin-mediated cell adhesion; RalA downstream regulated genes; Focal adhesion; MAPK signaling pathway; Microglia pathogen phagocytosis pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Regulation of actin cytoskeleton","RAC3 GTPase cycle; PCP/CE pathway","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Wnt signaling pathway; Axon guidance; VEGF signaling pathway; Focal adhesion; Adherens junction; Natural killer cell mediated cytotoxicity; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Regulation of actin cytoskeleton; Yersinia infection; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer; Choline metabolism in cancer; Viral myocarditis; Fluid shear stress and atherosclerosis",57.1,152,55.3,60.2,61,77.4,1.3313192346424974,0.41285655397931764,0.5358693686312318,0.27094106739123797,0.719282797021258,0.1431003265309704,5817]
["High","P61006","Ras-related protein Rab-8A [OS=Homo sapiens]",31,6,18,3,207,23.7,9.07,30.45,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB8A","ENSG00000167461","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape; Joubert syndrome","Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB geranylgeranylation; Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs; VxPx cargo-targeting to cilium","Autophagy; Endocytosis; AMPK signaling pathway; Tight junction; Pancreatic secretion; Amyotrophic lateral sclerosis; Pathways of neurodegeneration",229,216.6,196.7,225.7,213.7,248.2,0.9341186736474696,-0.0983222483713952,0.33568666054924023,0.4740659163181495,0.5764331307606043,0.23925106586462228,4547]
["High","P61088","ubiquitin-conjugating enzyme E2 N [OS=Homo sapiens]",48,6,56,6,152,17.1,6.57,137.06,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2N","ENSG00000177889","IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway; 3q29 copy number variation syndrome","ISG15 antiviral mechanism; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Nonhomologous End-Joining (NHEJ); Aggrephagy; E3 ubiquitin ligases ubiquitinate target proteins; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; Formation of Incision Complex in GG-NER; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Ubiquitin mediated proteolysis; Shigellosis",2823.7,3136.7,3138.5,3086.5,3127,2980.8,0.9896240061777406,-0.015047597429279216,0.7929659614259766,0.10074545465231487,0.8842442483310519,0.053427756422693304,7002]
["High","P61158","actin-related protein 3 [OS=Homo sapiens]",58,22,178,18,418,47.3,5.88,454.13,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ACTR3","ENSG00000115091","Physico-chemical features and toxicity-associated pathways","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Clathrin-mediated endocytosis","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",7961.1,8301.7,7934.6,8384.7,8381.1,8435.3,0.960172373428144,-0.05863466825515093,0.04880902761557301,1.3114998443696515,0.22260565865794046,0.6524638000521505,1712]
["High","P61289-1","Proteasome activator complex subunit 3 [OS=Homo sapiens]",54,15,134,15,254,29.5,5.95,309.53,"cell cycle OR cell proliferation;protein metabolism;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","HEL-S-283; LOC101359250; LOC103001388; LOC111151323; LOC111166421; Psme3; PSME3","ENSBTAG00000019918; ENSCAFG00000014716; ENSCATG00000043580; ENSCCAG00000025926; ENSCGRG00001014333; ENSCGRG00015000348; ENSECAG00000012620; ENSG00000131467; ENSGGOG00000010707; ENSLAFG00000013446; ENSMLUG00000004084; ENSMMUG00000012685; ENSMNEG00000003232; ENSMPUG00000010027; ENSMUSG00000078652; ENSNVIG00000013505; ENSOARG00000003731; ENSOGAG00000009420; ENSPPAG00000043945; ENSPTRG00000009225; ENSPTRG00000049975; ENSRBIG00000001980; ENSRNOG00000051344; ENSSBOG00000024784; ENSSSCG00000017385; ENSSSCG00005010026; ENSSSCG00015075406; ENSSSCG00025054060; ENSSSCG00030072129; ENSSSCG00035013193; ENSSSCG00040025703; ENSSSCG00045007466; ENSSSCG00050060716; ENSSSCG00055025037; ENSSSCG00060042579; ENSSSCG00065003129; ENSSSCG00070012475; ENSSSUG00005017981; ENSSTOG00000028833; ENSTSYG00000002969; ENSUAMG00000013177; ENSUMAG00000025062","Proteasome degradation; Proteasome degradation; Proteasome degradation; Proteasome degradation","Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Hedgehog ligand biogenesis; Hedgehog 'on' state; Regulation of expression of SLITs and ROBOs; ER-Phagosome pathway; Degradation of beta-catenin by the destruction complex; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Downstream TCR signaling; FCERI mediated NF-kB activation; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; FCERI mediated NF-kB activation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; UCH proteinases; ABC-family proteins mediated transport; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Hedgehog ligand biogenesis; Degradation of beta-catenin by the destruction complex; Downstream TCR signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of RUNX3 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Regulation of RAS by GAPs; Autodegradation of the E3 ubiquitin ligase COP1; Neddylation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Separation of Sister Chromatids; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX3 expression and activity; Regulation of PTEN stability and activity; Antigen processing: Ubiquitination & Proteasome degradation","Proteasome; Antigen processing and presentation; Hepatitis C",3426.2,2670.5,3510.6,3287.3,3481.8,3373.2,0.9472506236258047,-0.0781819103496735,0.5491719983383185,0.26029161505724924,0.7286210642354445,0.13749827757806735,5885]
["High","P61326","Protein mago nashi homolog [OS=Homo sapiens]",42,10,73,10,146,17.2,6.11,194.65,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","","MAGOH","ENSG00000162385","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",3464.6,2840.5,3724.7,3706.2,4617.5,4110.7,0.8066171266808209,-0.3100440564691745,0.09742285657196918,1.0113391404668228,0.3114978149524715,0.5065449954170511,2442]
["High","P61803","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [OS=Homo sapiens]",19,2,9,2,113,12.5,7.08,17.53,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity","DAD1","ENSG00000129562","","Asparagine N-linked glycosylation; Maturation of spike protein","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum",333.5,289.1,385.1,349.6,386.5,366.2,0.9141794429828541,-0.1294507172494413,0.34850066197232404,0.45779639262865623,0.5864424932499798,0.23177456852490172,4640]
["High","P61966","AP-1 complex subunit sigma-1A [OS=Homo sapiens]",16,2,4,2,158,18.7,5.73,11.33,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","AP1S1","ENSG00000106367","","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","Lysosome; Human immunodeficiency virus 1 infection",97.5,82.4,83.4,82.2,84.4,99,0.991340361445783,-0.012547625300862147,0.9201110952860574,0.03615973226659814,0.95598502089069,0.019548912530889723,7515]
["High","P61978-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein K [OS=Homo sapiens]",65,30,512,1,440,48.5,5.54,787.75,"","","","HNRNPK","","","","",21952.1,24539.1,21834.5,24622.1,23389.7,23848.8,0.9508089272842141,-0.07277264586847768,0.2839564611764633,0.5467482448838158,0.5301607003505082,0.2755924687068334,4182]
["High","P62191","26S proteasome regulatory subunit 4 [OS=Homo sapiens]",64,24,191,22,440,49.2,6.21,407.77,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMC1","ENSG00000100764","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; N-glycan trimming in the ER and Calnexin/Calreticulin cycle","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human papillomavirus infection; Epstein-Barr virus infection; Viral carcinogenesis",6416.2,5743.2,6514.5,6483.3,6297.4,6270.1,0.9802160539189956,-0.028828319574444296,0.6435884494977944,0.19139175879983353,0.7919840210683654,0.1012835805719217,6345]
["High","P62263","40S ribosomal protein S14 [OS=Homo sapiens]",38,7,101,7,151,16.3,10.05,285.12,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","RPS14","ENSG00000164587","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); rRNA modification in the nucleus and cytosol","Ribosome; Coronavirus disease",3567.5,4613.7,3732,3388.7,3818.8,3816.2,1.0806897865507952,0.11195245495729383,0.45042352085058784,0.34637893896287064,0.660204026807094,0.1803218310890649,5327]
["High","P62306","Small nuclear ribonucleoprotein F [OS=Homo sapiens]",15,1,10,1,86,9.7,4.67,8.85,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","SNRPF","ENSG00000139343","mRNA processing","snRNP Assembly; mRNA Splicing - Major Pathway; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","Spliceosome",177.4,214.6,209.2,239.8,273.2,236.3,0.8023488589350061,-0.31769844221764243,0.04042149730446232,1.3933876032645098,0.20102614710397565,0.6967474510151083,1570]
["High","P62316","Small nuclear ribonucleoprotein Sm D2 [OS=Homo sapiens]",56,6,37,6,118,13.5,9.91,74.8,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","SNRPD2","ENSG00000125743","mRNA processing","mRNA Splicing - Major Pathway; snRNP Assembly; mRNA Splicing - Minor Pathway","Spliceosome",1473.3,1683.4,1531.5,1944.8,1532.4,1478,0.9461172102034227,-0.07990917125466238,0.6079649772982779,0.21612143816837137,0.7684945026299099,0.11435923484742982,6177]
["High","P62487","DNA-directed RNA polymerase II subunit rpb7 [OS=Homo sapiens]",51,6,18,6,172,19.3,5.54,34.5,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR2G","ENSG00000168002","Pyrimidine metabolism; Eukaryotic transcription initiation","Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; mRNA Splicing - Major Pathway; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Inhibition of DNA recombination at telomere; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","RNA polymerase; Huntington disease",349.4,387.9,377,426.7,455.7,441.3,0.8418070559794515,-0.24843849256893025,0.00793505352548191,2.100450139388902,0.09695915168538773,1.0134111928886667,639]
["High","P62699","Protein yippee-like 5 [OS=Homo sapiens]",23,2,4,2,121,13.8,7.31,8.83,"cell cycle OR cell proliferation","non-structural extracellular;cytoskeleton;nucleus;other cell component","other molecular function","YPEL5","ENSG00000119801","Ciliary landscape","Neutrophil degranulation","",83.9,84.3,95.6,87.2,81.6,81.5,1.0539352776667996,0.07578627356321252,0.3516597978565723,0.453877277878713,0.5894718122937133,0.22953695741873956,4658]
["High","P62820","Ras-related protein Rab-1A [OS=Homo sapiens]",78,14,103,5,205,22.7,6.21,234.8,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB1A","ENSG00000138069","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization","Autophagy; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Legionellosis",4405.3,3908.5,5161.1,4801.1,5890.9,5316.3,0.8417445949913483,-0.24854554263511006,0.154217414962619,0.8118665809211549,0.3855682279949181,0.4138987604927182,3123]
["High","P62851","40S ribosomal protein S25 [OS=Homo sapiens]",37,5,10,5,125,13.7,10.11,15.49,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","other molecular function","RPS25","ENSG00000118181; ENSG00000280831","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",884.5,846.3,1039.5,1333.7,940.5,800.8,0.9009105691056911,-0.15054419407753122,0.582632289289259,0.2346054505844828,0.7526791718680566,0.12339010159283521,6044]
["High","P62873","Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [OS=Homo sapiens]",52,11,53,6,340,37.4,6,145.37,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","cytoskeletal activity;other molecular function","GNB1","ENSG00000078369","Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells; Estrogen signaling pathway","G alpha (q) signalling events; Thrombin signalling through proteinase activated receptors (PARs); G alpha (i) signalling events; Inactivation, recovery and regulation of the phototransduction cascade; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (12/13) signalling events; Olfactory Signaling Pathway; G alpha (z) signalling events; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Sensory perception of sweet, bitter, and umami (glutamate) taste; Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation; Activation of the phototransduction cascade","Ras signaling pathway; Chemokine signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Olfactory transduction; Phototransduction; Relaxin signaling pathway; Morphine addiction; Alcoholism; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",2189.9,2068.4,2308.6,2189.9,2401.3,2411,0.9378338236554224,-0.09259578304980752,0.2206302262066799,0.6563349897402151,0.4638343581641779,0.3336370844853413,3714]
["High","P62913","60S ribosomal protein L11 [OS=Homo sapiens]",33,6,50,6,178,20.2,9.6,106.77,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL11","ENSG00000142676","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",2356.3,2115.1,2538.4,2436.9,2728,2464.3,0.9188119330991453,-0.12215850100221406,0.2504718339877271,0.6012411042536464,0.4976295368387209,0.3030938499704377,3930]
["High","P62979","Ubiquitin-40S ribosomal protein S27a [OS=Homo sapiens]",63,11,613,11,156,18,9.64,1106.78,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle","other molecular function","RPS27A","ENSG00000143947","Cytoplasmic ribosomal proteins","Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Glycogen synthesis; Cargo recognition for clathrin-mediated endocytosis; InlA-mediated entry of Listeria monocytogenes into host cells; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Stimuli-sensing channels; Negative regulation of MAPK pathway; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oncogene Induced Senescence; ISG15 antiviral mechanism; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Orc1 removal from chromatin; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Regulation of PLK1 Activity at G2/M Transition; Peroxisomal protein import; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of PTEN stability and activity; Downregulation of ERBB4 signaling; Regulation of PTEN localization; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Oxidative Stress Induced Senescence; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Regulation of TP53 Degradation; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; ER Quality Control Compartment (ERQC); Deactivation of the beta-catenin transactivating complex; Circadian Clock; Regulation of signaling by CBL; Metalloprotease DUBs; Regulation of necroptotic cell death; Cyclin D associated events in G1; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Inactivation of CSF3 (G-CSF) signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Regulation of BACH1 activity; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Negative regulators of DDX58/IFIH1 signaling; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Formation of TC-NER Pre-Incision Complex; Modulation by Mtb of host immune system; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Formation of Incision Complex in GG-NER; Iron uptake and transport; Myoclonic epilepsy of Lafora; DNA Damage Recognition in GG-NER; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Ribosome; Ubiquitin mediated proteolysis; Mitophagy; Parkinson disease; Pathways of neurodegeneration; Shigellosis; Kaposi sarcoma-associated herpesvirus infection; Coronavirus disease",20532.3,20227.7,19756,19506.8,17752.8,18028.3,1.0945613778059937,0.13035285627634174,0.041721070901148696,1.3796445525827419,0.2043651954806581,0.6895930649842001,1594]
["High","P63096-1","Guanine nucleotide-binding protein G(i) subunit alpha-1 [OS=Homo sapiens]",30,9,17,4,354,40.3,5.97,37.11,"cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","Gnai1; GNAI1; LOC101343271; LOC111155312","ENSANAG00000026023; ENSBTAG00000002714; ENSCANG00000034777; ENSCCAG00000031786; ENSCGRG00001015780; ENSCGRG00015010768; ENSCHIG00000023476; ENSCSAG00000011871; ENSFCAG00000007172; ENSG00000127955; ENSGGOG00000008064; ENSLAFG00000022531; ENSLCNG00005007413; ENSMMUG00000023470; ENSMNEG00000038772; ENSMPUG00000018288; ENSMUSG00000057614; ENSPCTG00005000350; ENSPTRG00000019343; ENSSSCG00000015407; ENSSSCG00070000597; ENSSSUG00005001506; ENSTSYG00000026142; ENSTTRG00000006465; ENSVVUG00000019537","Calcium regulation in cardiac cell; G protein signaling pathways; S1P receptor signal transduction; Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Chemokine signaling pathway; G protein signaling pathways; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Common pathways underlying drug addiction; Nicotine activity on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone; G protein signaling pathways; Cell-type dependent selectivity of CCK2R signaling; Chemokine signaling pathway; Purinergic signaling; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Calcium regulation in cardiac cells; Signal transduction of S1P receptor; Serotonin HTR1 group and FOS pathway; Calcium regulation in cardiac cells; G protein signaling pathways","G alpha (i) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Extra-nuclear estrogen signaling; G alpha (i) signalling events; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Adenylate cyclase inhibitory pathway; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion; Adenylate cyclase inhibitory pathway; G alpha (i) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12","Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Axon guidance; Apelin signaling pathway; Gap junction; Platelet activation; Leukocyte transendothelial migration; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Long-term depression; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Gastric acid secretion; Parkinson disease; Cocaine addiction; Morphine addiction; Alcoholism; Pertussis; Chagas disease; Toxoplasmosis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Chemical carcinogenesis",245.4,199.3,267.7,199.5,270.9,230.6,1.016262482168331,0.023273072203633477,0.9015963657844877,0.0449878475419455,0.9449213992007087,0.024604315631602917,7450]
["High","P63167","Dynein light chain 1, cytoplasmic [OS=Homo sapiens]",45,3,7,2,89,10.4,7.4,14.67,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","DYNLL1","ENSG00000088986","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome","Neutrophil degranulation; MHC class II antigen presentation; COPI-mediated anterograde transport; HCMV Early Events; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria","Vasopressin-regulated water reabsorption; Salmonella infection",180.9,205.2,191.6,238.6,180.9,199.3,0.9335811247575956,-0.09915270210890978,0.49817085773553704,0.30262168164661674,0.6944684979823377,0.15834744965672204,5601]
["High","P63279","SUMO-conjugating enzyme ubc9 [OS=Homo sapiens]",6,1,9,1,158,18,8.66,16.67,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2I","ENSG00000103275","Androgen receptor signaling pathway; TGF-beta signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of RNA binding proteins; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Processing of DNA double-strand break ends; Formation of Incision Complex in GG-NER; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)","Nucleocytoplasmic transport; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; MicroRNAs in cancer",421.8,331.6,474.2,678.8,418,440,0.7988027069234774,-0.32408887319904217,0.33134937938247316,0.4797138385058692,0.5723840606677766,0.24231246865861594,4520]
["High","P68133","Actin, alpha skeletal muscle [OS=Homo sapiens]",40,17,1318,3,377,42,5.39,2621.67,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTA1","ENSG00000143632","Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Malignant pleural mesothelioma","Striated Muscle Contraction","",21458.1,20040.3,19777.9,14796.9,14007.9,14323.1,1.4208041662125908,0.506707717209885,4.462108569415036E-4,3.350459866924386,0.027007863341079533,1.5685097725649995,129]
["High","P68431","Histone H3.1 [OS=Homo sapiens]",57,8,86,1,136,15.4,11.12,147.96,"cell organization and biogenesis","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","H3C1; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8","ENSG00000197153; ENSG00000197409; ENSG00000273983; ENSG00000274750; ENSG00000275379; ENSG00000275714; ENSG00000277775; ENSG00000278828; ENSG00000286522; ENSG00000287080","Histone modifications; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma","Estrogen-dependent gene expression; Transcriptional regulation by small RNAs; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; HATs acetylate histones; Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Amyloid fiber formation; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Transcriptional regulation of granulopoiesis; B-WICH complex positively regulates rRNA expression; SIRT1 negatively regulates rRNA expression; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Late Events; HCMV Early Events; Formation of the beta-catenin:TCF transactivating complex; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Meiotic recombination; Assembly of the ORC complex at the origin of replication; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Interleukin-7 signaling; RMTs methylate histone arginines; PKMTs methylate histone lysines","Neutrophil extracellular trap formation; Alcoholism; Shigellosis; Transcriptional misregulation in cancer; Systemic lupus erythematosus",2766.1,3959.2,4179.2,3966,4248.3,3727.4,0.9131446946414666,-0.13108461068904692,0.4976729312140036,0.3030559802004979,0.6942701888366875,0.15847148244859235,5597]
["High","P78324","tyrosine-protein phosphatase non-receptor type substrate 1 [OS=Homo sapiens]",12,4,5,4,504,54.9,6.98,7.62,"cell adhesion;stress response;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","SIRPA","ENSG00000198053","Prolactin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Male infertility","Neutrophil degranulation; Cell surface interactions at the vascular wall; Signal regulatory protein family interactions","Osteoclast differentiation",136.3,132.9,133.1,207.2,153.8,195.9,0.7223918118154069,-0.4691465546713812,0.03403656658352692,1.4680542555508274,0.1876818586752671,0.7265777042459421,1416]
["High","P78362-1","SRSF protein kinase 2 [OS=Homo sapiens]",22,15,40,11,688,77.5,4.97,74.58,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","SRPK2","ENSG00000135250","mRNA processing","Maturation of nucleoprotein","",1403,1020.3,1304.9,1317.1,1231.3,1294.2,0.9702284911258003,-0.04360354944824291,0.7619810479363052,0.11805583033893076,0.863880938331156,0.06354610866561547,6887]
["High","P78368","casein kinase I isoform gamma-2 [OS=Homo sapiens]",10,4,6,1,415,47.4,9.06,10.9,"cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK1G2","ENSG00000133275","Hedgehog signaling pathway","Disassembly of the destruction complex and recruitment of AXIN to the membrane; Sphingolipid de novo biosynthesis","Hedgehog signaling pathway",335.2,310.8,348.3,357.3,384.8,374.1,0.8907901809711521,-0.16684243925638223,0.040372878869011086,1.393910281247406,0.20091232518115903,0.6969934201757073,1569]
["High","P78536-1","Disintegrin and metalloproteinase domain-containing protein 17 [OS=Homo sapiens]",15,11,15,11,824,93,5.76,25,"cell adhesion;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM17","ENSG00000151694; ENSPPAG00000038185","Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Notch signaling; Copper homeostasis; Ebola virus infection in host; Soluble ACE2-mediated cell entry of SARS-CoV-2; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Notch signaling pathway","Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; Release of Hh-Np from the secreting cell; Growth hormone receptor signaling; Nuclear signaling by ERBB4; TNF signaling; CD163 mediating an anti-inflammatory response; Regulated proteolysis of p75NTR","Notch signaling pathway; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Coronavirus disease",475.7,511.2,476.5,510.4,533.3,502,0.9467555153005113,-0.0789361743694076,0.1410256651568135,0.8507018432192859,0.3708751746528797,0.43077223615669513,2969]
["High","P78563-1","Double-stranded RNA-specific editase 1 [OS=Homo sapiens]",1,1,2,1,741,80.7,9.01,3.57,"cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ADARB1","ENSG00000197381","","C6 deamination of adenosine; Formation of editosomes by ADAR proteins","",86.6,82.2,101.8,74.2,63,67.1,1.3245227606461087,0.4054726352433099,0.031080724998981738,1.5075088592602859,0.18083330908498466,0.7427215704346238,1342]
["High","P81605","Dermcidin [OS=Homo sapiens]",16,2,3,2,110,11.3,6.54,2.57,"protein metabolism;stress response;other biological processes","non-structural extracellular","other molecular function","DCD","ENSG00000161634","","Antimicrobial peptides","",53.3,59.3,58.6,49.6,51.9,62.3,1.045177045177045,0.0637473447601381,0.600325225074174,0.22161340763470644,0.764032495090326,0.11688817003909412,6135]
["High","P82912-1","28S ribosomal protein S11, mitochondrial [OS=Homo sapiens]",29,3,6,3,194,20.6,10.81,19.37,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS11","ENSG00000181991","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",260.3,294.9,260.1,290.9,300.4,291.8,0.9232250028309368,-0.11524579922745953,0.1317233689921816,0.88033717018604,0.3593627061813256,0.4444669949511621,2862]
["Medium","P83369","U7 snRNA-associated Sm-like protein LSm11 [OS=Homo sapiens]",3,1,1,1,360,39.5,10.99,2.63,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","LSM11","ENSG00000155858","","RNA Polymerase II Transcription Termination; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","",27.8,42.9,16.4,27.7,24.4,27,1.1011378002528445,0.13899502412607273,0.7478017154774688,0.12621354289730605,0.8552564515084335,0.06790364109034806,6827]
["High","P84022","Mothers against decapentaplegic homolog 3 [OS=Homo sapiens]",10,4,8,1,425,48.1,7.15,23.23,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","SMAD3","ENSG00000166949","Androgen receptor signaling pathway; Cell cycle; AGE/RAGE pathway; Adipogenesis; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Ovarian infertility; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularisation processes; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; TGF-beta receptor signaling; DNA damage response (only ATM dependent)","Ub-specific processing proteases; Interleukin-37 signaling; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX3 regulates BCL2L11 (BIM) transcription; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates CDKN1A transcription; NOTCH4 Intracellular Domain Regulates Transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer","FoxO signaling pathway; Cell cycle; Endocytosis; Cellular senescence; Wnt signaling pathway; TGF-beta signaling pathway; Apelin signaling pathway; Hippo signaling pathway; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Th17 cell differentiation; AGE-RAGE signaling pathway in diabetic complications; Hepatitis B; Human T-cell leukemia virus 1 infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer; Chronic myeloid leukemia; Hepatocellular carcinoma; Gastric cancer; Inflammatory bowel disease; Diabetic cardiomyopathy",197.7,179.2,185.4,232.6,217.6,240.5,0.8141016360214274,-0.2967191767708337,0.007741833392073308,2.111156179139742,0.0961021226157526,1.0172670199263756,629]
["High","P84103","Serine/arginine-rich splicing factor 3 [OS=Homo sapiens]",43,9,79,8,164,19.3,11.65,141.64,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SRSF3","ENSG00000112081","mRNA processing","mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection",3160.7,4102.3,3066.7,3026.4,2950.1,3123.2,1.1351692912953175,0.18290746711927625,0.2874395718936276,0.5414534426318708,0.5324622010309477,0.2737112169339965,4215]
["High","P86397","Hydroxyacyl-thioester dehydratase type 2, mitochondrial [OS=Homo sapiens]",17,1,2,1,168,18.5,8.92,5.04,"other metabolic processes","mitochondrion;nucleus","other molecular function","HTD2","ENSG00000255154","Mitochondrial fatty acid synthesis pathway","Fatty acyl-CoA biosynthesis","Fatty acid biosynthesis; Metabolic pathways; Fatty acid metabolism",33.8,31,28.6,29.7,28.1,31.8,1.0424107142857144,0.05992381765205798,0.5301893249779549,0.2755690207557744,0.7163381639432207,0.144881910563522,5779]
["High","P98171-1","Rho GTPase-activating protein 4 [OS=Homo sapiens]",7,5,7,5,946,105,6.34,7.93,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","ARHGAP4","ENSG00000089820","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle","",385.3,392.8,370.3,432.1,412.3,407.8,0.9171058936272161,-0.12483977067380954,0.02559806113876885,1.591792927993699,0.16655805114292263,0.7784343693826885,1200]
["High","P98198-1","Phospholipid-transporting ATPase ID [OS=Homo sapiens]",4,3,6,3,1209,137.4,7.01,5.74,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi","transporter activity;other molecular function","ATP8B2","ENSG00000143515; ENSPPAG00000034141; ENSPTRG00000001382","Mesodermal commitment pathway; Complement system in neuronal development and plasticity","Ion transport by P-type ATPases","",154,129.6,171.4,162.2,171.7,174.8,0.8944367996854727,-0.1609485488892079,0.23155057407683588,0.63535413793464,0.47703083968124926,0.32145354324407693,3790]
["High","Q00341-1","Vigilin [OS=Homo sapiens]",48,53,183,52,1268,141.4,6.87,403.1,"other metabolic processes;transport","non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","HDLBP","ENSG00000115677","","HDL clearance","",6785.8,6447,6816.5,6906.4,7166.8,6984.7,0.9521034861026028,-0.07080970331535245,0.0760374898422009,1.1189722285461354,0.277430243312105,0.5568461972366908,2140]
["High","Q00688","peptidyl-prolyl cis-trans isomerase FKBP3 [OS=Homo sapiens]",54,10,29,10,224,25.2,9.28,56.54,"protein metabolism;other metabolic processes","nucleus","other molecular function","FKBP3","ENSG00000100442","","","",1451.7,1582.2,1353.1,1648.9,1416.5,1349.8,0.99361297336474,-0.009244084285102894,0.9373345590228018,0.02810537047377012,0.9664212646045209,0.014833522639747505,7573]
["High","Q01081","Splicing factor U2AF 35 kDa subunit [OS=Homo sapiens]",47,8,66,8,240,27.9,8.81,83.97,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","U2AF1","ENSG00000160201","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","Spliceosome; Shigellosis",2382.9,2483.4,2331.2,2320.7,2166.2,2260.8,1.0666597507298783,0.0931000503726812,0.07724161897473286,1.1121486320388858,0.2801219512098068,0.5526528572037376,2153]
["High","Q01082-1","Spectrin beta chain, non-erythrocytic 1 [OS=Homo sapiens]",69,146,748,14,2364,274.4,5.57,1717.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SPTBN1","ENSG00000115306; ENSPPAG00000020369; ENSPTRG00000011924","TGF-beta signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways","RHOV GTPase cycle; RHOU GTPase cycle; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Signaling by FLT3 fusion proteins; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Nephrin family interactions; Interaction between L1 and Ankyrins","",29999,29226.1,28939.5,30518,30612.4,30555.3,0.9615959740722927,-0.056497238977715816,0.020916431141605196,1.679512414820472,0.1526313031342555,0.8163563878470463,1070]
["High","Q01518-1","adenylyl cyclase-associated protein 1 [OS=Homo sapiens]",52,23,219,1,475,51.9,8.06,510.69,"cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CAP1","ENSG00000131236","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity","Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling","",212,209.8,209.5,196.5,199.9,201.9,1.055156276115661,0.07745668810803251,0.0033571943697341,2.47402351390263,0.0624118419973425,1.204732999641895,420]
["High","Q01780","exosome component 10 [OS=Homo sapiens]",34,27,72,27,885,100.8,8.46,142.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","EXOSC10","ENSG00000171824","","Major pathway of rRNA processing in the nucleolus and cytosol","RNA degradation",2866.2,2895.3,2786.1,3218.3,3295.4,3227.2,0.87749591926824,-0.18853567860425224,6.1599147204934545E-4,3.210425300282893,0.03103007363716961,1.508217193794549,155]
["High","Q01844","RNA-binding protein EWS [OS=Homo sapiens]",7,4,36,4,656,68.4,9.33,89.93,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","EWSR1","ENSG00000182944","VEGFA-VEGFR2 signaling pathway","","Transcriptional misregulation in cancer",1387.8,1168.6,1338.8,1561.1,1298.1,1445.3,0.9049134626553607,-0.14414826177147982,0.24815879352041284,0.605270330945287,0.49695405483646665,0.3036837614746373,3899]
["High","Q01970-1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [OS=Homo sapiens]",34,32,82,32,1234,138.7,5.9,165.67,"other metabolic processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","other molecular function","PLCB3","ENSG00000149782","Alzheimer's disease and miRNA effects; S1P receptor signal transduction; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; GPR40 pathway; MAPK cascade; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; Calcium regulation in cardiac cells","G alpha (q) signalling events; Synthesis of IP3 and IP4 in the cytosol; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Inositol phosphate metabolism; Metabolic pathways; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Apelin signaling pathway; Gap junction; Platelet activation; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Pathways in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis",3088.4,3632.8,3035.3,3190.4,2968.5,3310.1,1.0303622346604708,0.043151621171409166,0.6796310210905481,0.16772680640543713,0.8142640805086695,0.08923472274240121,6517]
["High","Q02127","Dihydroorotate dehydrogenase (Quinone), mitochondrial [OS=Homo sapiens]",17,5,9,5,395,42.8,9.67,20.63,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","DHODH","ENSG00000102967","Pyrimidine metabolism","Pyrimidine biosynthesis","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",260.2,375.7,289.1,315.7,282.7,325.3,1.0014073833495722,2.028997525063231E-3,0.9912216201466582,3.8292338636408295E-3,0.9955567803068056,0.001933965500253045,7774]
["High","Q02318","Sterol 26-hydroxylase, mitochondrial [OS=Homo sapiens]",10,5,7,5,531,60.2,8.9,11.54,"other metabolic processes","other membranes;mitochondrion","other molecular function","CYP27A1","ENSG00000135929","Vitamin D metabolism; PPAR signaling pathway; Oxidation by cytochrome P450; Vitamin D-sensitive calcium signaling in depression; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Metapathway biotransformation Phase I and II","Endogenous sterols; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol; Defective CYP27A1 causes CTX","Primary bile acid biosynthesis; Metabolic pathways; PPAR signaling pathway; Cholesterol metabolism",285,321,311,415.5,473,409,0.7067437379576108,-0.5007408996501888,0.005272254412435635,2.2780036410447297,0.07708944279456449,1.113005093414651,534]
["High","Q02880","DNA topoisomerase 2-beta [OS=Homo sapiens]",39,55,218,39,1626,183.2,8,460.98,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP2B","ENSG00000077097","","SUMOylation of DNA replication proteins","Platinum drug resistance",5256.5,4510.6,5236.4,5935.7,6314.1,6231.4,0.8118249897192825,-0.300759344911883,0.01285685370087777,1.8908652979380143,0.12182805060249227,0.9142527049764947,824]
["High","Q03013-1","glutathione S-transferase mu 4 [OS=Homo sapiens]",46,9,31,2,218,25.5,5.9,59.38,"other metabolic processes","non-structural extracellular;cytosol;other cell component","other molecular function","GSTM4","ENSG00000168765","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II","Glutathione conjugation; Biosynthesis of maresin conjugates in tissue regeneration (MCTR)","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",54.9,49,62.9,64.7,60.9,64.6,0.8769716088328076,-0.18939795741589985,0.13807423481413952,0.8598873548898558,0.36744499844199097,0.43480765973848423,2934]
["High","Q03135","Caveolin-1 [OS=Homo sapiens]",27,4,6,4,178,20.5,6.02,10.73,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","CAV1","ENSG00000105974","Androgen receptor signaling pathway; Integrin-mediated cell adhesion; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host; Acute viral myocarditis; EGF/EGFR signaling pathway; Congenital generalized lipodystrophy (CGL)","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RND1 GTPase cycle; RHOH GTPase cycle; Basigin interactions; Triglyceride catabolism; RHOD GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; NOSTRIN mediated eNOS trafficking; RND3 GTPase cycle; Disassembly of the destruction complex and recruitment of AXIN to the membrane; FOXO-mediated transcription of cell cycle genes; VEGFR2 mediated vascular permeability; eNOS activation","Endocytosis; Focal adhesion; Prion disease; Bacterial invasion of epithelial cells; Proteoglycans in cancer; Viral myocarditis; Fluid shear stress and atherosclerosis",421.4,476.4,432.9,431,405,409.1,1.0687494980322865,0.09592374239713101,0.1996450552508199,0.6997414418126295,0.4410946778150543,0.35546818232473937,3534]
["High","Q03426","mevalonate kinase [OS=Homo sapiens]",15,4,12,4,396,42.4,6.46,11.91,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","MVK","ENSG00000110921","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Terpenoid backbone biosynthesis; Metabolic pathways; Peroxisome",275.6,260.2,298.5,292.5,291.9,287,0.9574248336011016,-0.0627688678473247,0.3338336724784229,0.4764698598855757,0.5745147266280638,0.24069883449295706,4537]
["High","Q04726","Transducin-like enhancer protein 3 [OS=Homo sapiens]",20,13,23,10,772,83.4,7.2,57.7,"cell-cell signaling;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","TLE3","ENSG00000140332","White fat cell differentiation","Estrogen-dependent gene expression; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes","Wnt signaling pathway; Notch signaling pathway",880.7,846.7,898.8,895.4,944,917.8,0.9524880313361381,-0.0702271306178707,0.10310707053193924,0.9867115521004111,0.31934153380142066,0.4957445931182216,2521]
["High","Q04727-1","Transducin-like enhancer protein 4 [OS=Homo sapiens]",16,10,20,2,773,83.7,7.5,44.85,"cell-cell signaling;signal transduction;other biological processes","nucleus;other cell component","other molecular function","TLE4","ENSG00000106829","","Formation of the beta-catenin:TCF transactivating complex; NOTCH1 Intracellular Domain Regulates Transcription; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes","Wnt signaling pathway; Notch signaling pathway",145.6,138.6,140.8,162.4,138.8,155.2,0.9312007011393513,-0.10283595037625548,0.224020969184441,0.6497113282066209,0.4679389318866012,0.3298108205907988,3738]
["High","Q05086","Ubiquitin-protein ligase E3A [OS=Homo sapiens]",27,22,39,22,875,100.6,5.22,96.32,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE3A","ENSG00000114062","Androgen receptor signaling pathway; MECP2 and associated Rett syndrome; Prader-Willi and Angelman syndrome; Synaptic signaling pathways associated with autism spectrum disorder","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis; Human papillomavirus infection; Viral carcinogenesis",1531.1,1014.9,1483.3,1375.7,1394.9,1382.5,0.9701909417061954,-0.04365938517173912,0.814582772105606,0.08906477919795758,0.8965692535382819,0.04741615867524614,7094]
["High","Q05519","serine/arginine-rich splicing factor 11 [OS=Homo sapiens]",28,15,76,15,484,53.5,10.52,131.75,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","SRSF11","ENSG00000116754","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",4485.9,4780.9,4274.2,4439.4,4453.4,4532.7,1.008603031544449,0.012358466703303414,0.8098172486742271,0.09161297722893015,0.8934651798287927,0.048922368175552594,7077]
["High","Q05932-1","Folylpolyglutamate synthase, mitochondrial [OS=Homo sapiens]",13,5,5,5,587,64.6,7.94,9.7,"cell cycle OR cell proliferation;other metabolic processes;developmental processes","other membranes;cytosol;mitochondrion;other cell component","other molecular function","FPGS","ENSG00000136877","Fluoropyrimidine activity","","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance",194.6,174.1,188.6,93.2,81.9,90.4,2.0990583804143124,1.0697422923865894,1.5287317119839458E-4,3.8156687253322494,0.0172990394306821,1.7619780114108694,69]
["High","Q06203","amidophosphoribosyltransferase [OS=Homo sapiens]",43,16,53,16,517,57.4,6.76,119.08,"cell cycle OR cell proliferation;other metabolic processes;transport;developmental processes;other biological processes","cytosol","other molecular function","PPAT","ENSG00000128059","Fluoropyrimidine activity; Metabolic reprogramming in colon cancer","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Alanine, aspartate and glutamate metabolism; Metabolic pathways",1725.4,1621.7,1864.2,1677.8,1750.9,1759,1.0045492221986623,6.54825683586317E-3,0.9213498109857163,0.03557544891600412,0.9570173372590758,0.019080194503463856,7517]
["High","Q06546","GA-binding protein alpha chain [OS=Homo sapiens]",27,8,23,8,454,51.3,4.97,65,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GABPA","ENSG00000154727","Energy metabolism; Allograft rejection; Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression; Malignant pleural mesothelioma","Transcriptional activation of mitochondrial biogenesis","",705.8,633.1,728.2,780,731.6,743.2,0.9167553663296081,-0.12539128894965315,0.12393511766733148,0.9068056165605648,0.3495973261367501,0.4564318976866495,2768]
["High","Q06787","synaptic functional regulator FMR1 [OS=Homo sapiens]",16,10,25,2,632,71.1,7.42,45.38,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","FMR1","ENSG00000102081","Serotonin and anxiety; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome","","",868.4,780.3,853.1,889,881.5,868.1,0.9481543242628666,-0.07680619955206057,0.17698534799823804,0.752062685880588,0.4159848275647931,0.38092250933732824,3322]
["High","Q07065","Cytoskeleton-associated protein 4 [OS=Homo sapiens]",67,40,173,40,602,66,5.92,454.28,"","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","","CKAP4","ENSG00000136026","","Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RND2 GTPase cycle; RND3 GTPase cycle; Surfactant metabolism","Protein processing in endoplasmic reticulum",8104.7,8379.2,8135.7,8886.8,8626.8,8541.2,0.9449160999124924,-0.08174185826661695,0.024156961176421823,1.6169576986650027,0.16066231078833185,0.794085990917963,1174]
["High","Q07820","Induced myeloid leukemia cell differentiation protein Mcl-1 [OS=Homo sapiens]",49,10,31,10,350,37.3,5.66,88.8,"stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","transporter activity;other molecular function","MCL1","ENSG00000143384","Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-Akt signaling pathway; MicroRNA network associated with chronic lymphocytic leukemia; Host-pathogen interaction of human coronaviruses - apoptosis; Malignant pleural mesothelioma","Interleukin-4 and Interleukin-13 signaling","PI3K-Akt signaling pathway; Apoptosis; JAK-STAT signaling pathway; MicroRNAs in cancer",1164.9,1028.2,1134,829.5,792,816.9,1.3644603018372705,0.4483304208666182,0.002293027835828179,2.639590673192782,0.05250428546083994,1.2798052475266444,341]
["High","Q07954","prolow-density lipoprotein receptor-related protein 1 [OS=Homo sapiens]",19,65,111,65,4544,504.3,5.39,219.85,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","LRP1","ENSG00000123384","Alzheimer's disease and miRNA effects; Regulation of Wnt / B-catenin signaling by small molecule compounds; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Alzheimer's disease","Retinoid metabolism and transport; Scavenging of heme from plasma","Cholesterol metabolism; Alzheimer disease; Malaria",3404.3,3325.5,3567.2,3980.1,3983.7,4102.8,0.8533472560621883,-0.22879515211148727,1.9600099009269554E-3,2.70774173481338,0.04984937233367318,1.3023403056319311,307]
["High","Q08345-1","Epithelial discoidin domain-containing receptor 1 [OS=Homo sapiens]",1,1,1,1,913,101.1,6.83,3.57,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","DDR1","ENSG00000137332; ENSG00000204580; ENSG00000215522; ENSG00000230456; ENSG00000234078; ENSPPAG00000026163; ENSPTRG00000017942","Interactions between LOXL4 and oxidative stress pathway","Non-integrin membrane-ECM interactions","",63.6,95.8,65.7,99.3,65.5,79.6,0.9210310965630116,-0.11867822836457358,0.6759265333374295,0.17010050509392755,0.8131948185360014,0.0898053972356614,6490]
["High","Q08623","Pseudouridine-5'-phosphatase [OS=Homo sapiens]",12,2,7,2,228,25.2,5.31,11.08,"other metabolic processes","cytosol","other molecular function","PUDP","ENSG00000130021","","Pyrimidine salvage","",159.9,156.4,169.3,156.9,154.9,165.3,1.0178159714944457,0.025476735271377268,0.6011237227450246,0.22103613269688804,0.7644257373278749,0.11666469917942032,6140]
["High","Q08AD1","Calmodulin-regulated spectrin-associated protein 2 [OS=Homo sapiens]",15,15,19,15,1489,168,6.8,35.55,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi","cytoskeletal activity;other molecular function","CAMSAP2","ENSG00000118200","","","",541.1,539.9,498.8,546.3,501.6,495.8,1.0233853728055968,0.03334951824206958,0.6000334497564852,0.22182453855012443,0.7639101868088434,0.11695769857898201,6133]
["High","Q09028","Histone-binding protein RBBP4 [OS=Homo sapiens]",38,15,119,8,425,47.6,4.89,322.27,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBBP4","ENSG00000162521","Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Malignant pleural mesothelioma","RNA Polymerase I Transcription Initiation; HCMV Early Events; Transcriptional Regulation by E2F6; G1/S-Specific Transcription; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1","Cellular senescence",2457.4,2465.2,2343,2451.7,2466.7,2544.6,0.9735495109205414,-0.03867374424872576,0.2494739738405127,0.6029747550787428,0.4970382209101105,0.30361021389820997,3919]
["Medium","Q09328","Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A [OS=Homo sapiens]",1,1,1,1,741,84.5,8.12,2.01,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","MGAT5","ENSG00000152127","","N-Glycan antennae elongation; Maturation of spike protein","N-Glycan biosynthesis; Metabolic pathways",64.6,69.2,60.3,53.9,60.8,56.3,1.1350877192982456,0.1828037929404035,0.07811404745027975,1.1072708588044742,0.280549439968622,0.5519905938961145,2174]
["High","Q0VG06","Fanconi anemia core complex-associated protein 100 [OS=Homo sapiens]",8,4,5,4,881,93.4,5.29,13.18,"DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","nucleic acid binding activity","FAAP100","ENSG00000185504","DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",148.1,142.7,161.8,151.4,132.7,140.6,1.065693430656934,0.09179247591948995,0.3019371924842424,0.5200833874876485,0.5449666201842267,0.26363009793208575,4326]
["High","Q10589","bone marrow stromal antigen 2 [OS=Homo sapiens]",22,4,16,4,180,19.8,5.6,37.57,"stress response;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","BST2","ENSG00000130303","Ebola virus infection in host; Host-pathogen interaction of human coronaviruses - MAPK signaling","Neutrophil degranulation; Interferon alpha/beta signaling","Herpes simplex virus 1 infection; Human immunodeficiency virus 1 infection",520.5,594.6,609.3,853.7,835.5,819.3,0.6874227626071358,-0.5407304704731665,8.6410950300616651E-4,3.0634312187040518,0.035698238092445225,1.4473532182186604,189]
["High","Q12767","Transmembrane protein 94 [OS=Homo sapiens]",2,2,2,2,1356,151.1,6.44,7.02,"","other membranes","","TMEM94","ENSG00000177728","","","",44.3,74.1,54.9,48.9,50,43.9,1.2135854341736692,0.2792756751310696,0.31804168439786734,0.4975159551175764,0.5604309347277247,0.25147790049055296,4431]
["High","Q12797","Aspartyl/Asparaginyl beta-hydroxylase [OS=Homo sapiens]",32,18,71,18,758,85.8,5.01,161.12,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","ASPH","ENSG00000198363","","Stimuli-sensing channels; Ion homeostasis","Calcium signaling pathway; Cardiac muscle contraction",2561,2354.9,2586.3,2415.3,2360.7,2398.9,1.045617360520704,0.06435499969778687,0.21967724794496704,0.6582149207928685,0.46232882802002767,0.3350490257492789,3710]
["High","Q12824-1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [OS=Homo sapiens]",43,14,64,14,385,44.1,6.23,125.24,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101347788; LOC111142756; Smarcb1; SMARCB1","ENSCAFG00000014105; ENSCATG00000029590; ENSCCAG00000036123; ENSCHIG00000019816; ENSCSAG00000011285; ENSDLEG00000015913; ENSECAG00000007797; ENSG00000099956; ENSG00000275837; ENSHGLG00000019077; ENSMFAG00000040790; ENSMLUG00000004975; ENSMMUG00000009098; ENSMNEG00000033936; ENSMUSG00000000902; ENSPANG00000026464; ENSPPAG00000028391; ENSRBIG00000027964; ENSRFEG00010017090; ENSRROG00000030710; ENSSBOG00000031674; ENSSSCG00000010070; ENSSSCG00070020965; ENSSSUG00005014167; ENSSTOG00000012408; ENSTSYG00000008262; ENSUAMG00000010813","TNF-alpha NF-kB signaling pathway; Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation","RMTs methylate histone arginines; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",1432.7,1384.3,1478.6,1584.6,1512.9,1572.4,0.9198483907578322,-0.12053199885468967,0.023693009178462492,1.6253797773267493,0.16016884473197848,0.795421956896277,1155]
["High","Q12851","Mitogen-activated protein kinase kinase kinase kinase 2 [OS=Homo sapiens]",8,5,7,5,820,91.5,6.34,12.27,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","kinase activity;other molecular function","MAP4K2","ENSG00000168067","TNF-alpha signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma","","MAPK signaling pathway",95.7,112.1,89.8,105.5,116.1,107.3,0.9048342961386441,-0.14427448172737073,0.23301651637736015,0.6326132947794323,0.47916590989581986,0.31951408726059405,3797]
["High","Q12887","Protoheme IX farnesyltransferase, mitochondrial [OS=Homo sapiens]",4,1,1,1,443,48.9,9.19,2.28,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","COX10","ENSG00000006695","Mitochondrial complex IV assembly","Heme biosynthesis","Oxidative phosphorylation; Porphyrin metabolism; Metabolic pathways; Biosynthesis of cofactors; Thermogenesis",18.6,14.4,27.3,18,19.1,20.7,1.0432525951557092,0.06108850939940583,0.8403952633769375,0.07551640402317208,0.9118685681555208,0.04006775403805048,7196]
["High","Q12906-7","Isoform 7 of Interleukin enhancer-binding factor 3 [OS=Homo sapiens]",68,50,542,3,898,95.7,8.81,1315.87,"","","","ILF3","","","","",23763.6,24075.6,23119.2,24101.6,23152.1,23981,0.9961212723574326,-5.606701612001312E-3,0.8333981145540992,0.07914748640775077,0.9075554363233481,0.04212683741691551,7170]
["High","Q12959","Disks large homolog 1 [OS=Homo sapiens]",24,18,28,16,904,100.4,5.76,72.85,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","DLG1","ENSG00000075711","Brain-derived neurotrophic factor (BDNF) signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Disruption of postsynaptic signaling by CNV; 3q29 copy number variation syndrome","Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; NrCAM interactions; Activation of Ca-permeable Kainate Receptor","Hippo signaling pathway; Tight junction; T cell receptor signaling pathway; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Viral carcinogenesis",1313.8,1295.6,1270,1442.2,1413.4,1433.8,0.9044155359723969,-0.14494232009356256,0.000871610692564429,3.0596774506455557,0.035818612039700326,1.4458912469397494,190]
["High","Q12974","Protein tyrosine phosphatase type IVA 2 [OS=Homo sapiens]",19,3,6,2,167,19.1,8.37,8.28,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PTP4A2","ENSG00000184007","","RAB geranylgeranylation","",217.5,171.4,211.8,219.8,234.3,230.5,0.8774466841951505,-0.188616628483368,0.13854821974835776,0.8583990502385294,0.3682043906722864,0.43391103703413164,2938]
["High","Q12999","Tetraspanin-31 [OS=Homo sapiens]",3,1,2,1,210,23,7.97,5.24,"other biological processes","plasma membrane;other membranes","","TSPAN31","ENSG00000135452","","","",99.8,78.1,125.2,104.1,108,123.8,0.9023518904435843,-0.1482379434501696,0.5033308137878877,0.29814648138825983,0.6976756602264915,0.15634642796497528,5633]
["High","Q13045-1","protein flightless-1 homolog [OS=Homo sapiens]",36,36,80,36,1269,144.7,6.05,191.17,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLII","ENSG00000177731; ENSG00000284571","VEGFA-VEGFR2 signaling pathway","","",3706.2,3315.1,3725.6,3680,3707.7,3631,0.9753328432573715,-0.03603345615624387,0.5405763066034701,0.26714299329669033,0.7221248591890325,0.14138770413591384,5845]
["High","Q13111-1","Chromatin assembly factor 1 subunit A [OS=Homo sapiens]",25,17,31,17,956,106.9,5.94,52.65,"","","","","","","","",1314,1334.6,1195.2,1497.2,1402.2,1501.9,0.8733328789221365,-0.19539643961906122,0.026631317577195453,1.574607346428122,0.16933007137031117,0.7712659085746355,1228]
["High","Q13123","Protein Red [OS=Homo sapiens]",31,14,58,14,557,65.6,6.64,127.66,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","IK","ENSG00000113141","","","",3154.6,2991.4,2866.6,3251.5,3080.8,2900.9,0.976107958237664,-0.034887375172246035,0.604916601951428,0.2183044961060532,0.7673743018743705,0.11499274871475292,6155]
["High","Q13136","Liprin-alpha-1 [OS=Homo sapiens]",23,27,39,22,1202,135.7,6.29,100.62,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;other cell component","","PPFIA1","ENSG00000131626","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",2193.5,2067.3,2052.2,2109.1,1934.8,2052.2,1.0355801249979497,0.05043918220654491,0.34834498378180445,0.45799043898779496,0.5864332974058493,0.23178137863112816,4638]
["High","Q13158","FAS-associated death domain protein [OS=Homo sapiens]",48,7,28,7,208,23.3,5.69,60.07,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","FADD","ENSG00000168040","TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor (RLR) pathway; VEGFA-VEGFR2 signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Alzheimer's disease; Toll-like receptor signaling pathway","Regulation of TNFR1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL  signaling; TLR3-mediated TICAM1-dependent programmed cell death; TNFR1-induced proapoptotic signaling; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis","Platinum drug resistance; Apoptosis; Apoptosis; Necroptosis; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Alcoholic liver disease; Alzheimer disease; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Salmonella infection; Chagas disease; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",818.8,679.2,833,874.7,886.1,856.1,0.8907485956666283,-0.16690979104620346,0.12845634136808226,0.8912444515129538,0.35503968615999515,0.44972309900977575,2825]
["High","Q13206","probable ATP-dependent RNA helicase DDX10 [OS=Homo sapiens]",22,18,36,18,875,100.8,8.63,70.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX10","ENSG00000178105","","","",1571.8,1665.3,1579.9,1569.5,1632.9,1658.6,0.9909483645340466,-0.013118210201604164,0.7320872889284182,0.13543713364127136,0.846584353073621,0.07232976260023465,6752]
["High","Q13257-1","Mitotic spindle assembly checkpoint protein MAD2A [OS=Homo sapiens]",35,8,25,8,205,23.5,5.08,53.29,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD2L1","ENSANAG00000022503; ENSCANG00000042550; ENSCATG00000040684; ENSCCAG00000030445; ENSG00000164109; ENSGGOG00000002516; ENSMLEG00000036707; ENSMMUG00000054168; ENSMNEG00000040691; ENSPANG00000019721; ENSPPAG00000028274; ENSPTRG00000016401; ENSRBIG00000035049; ENSRROG00000029952; ENSSBOG00000031396","Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; Cell cycle","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection",1195.6,934.6,1196.6,1371.3,1604.7,1469.5,0.7483522663367449,-0.4182105557040373,0.0277999552040551,1.5559559038893827,0.17268261752845046,0.7627513769167049,1257]
["High","Q13283","Ras GTPase-activating protein-binding protein 1 [OS=Homo sapiens]",45,15,98,14,466,52.1,5.52,224.81,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","G3BP1","ENSG00000145907","","","",4596.4,6162.7,4488.4,4686.6,4104.8,4375.9,1.1579822742703512,0.21161316954650486,0.28811960153078997,0.5404271945239012,0.5323326665292021,0.2738168825815604,4226]
["High","Q13362","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [OS=Homo sapiens]",13,7,13,4,524,61,6.87,26.83,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","PPP2R5C","ENSG00000078304","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)","Platelet sensitization by LDL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF activation; Negative regulation of MAPK pathway; CTLA4 inhibitory signaling","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; Dopaminergic synapse; Human papillomavirus infection",385,382.3,388.9,413,424.2,421.6,0.9184938036224972,-0.12265810628154716,9.2215407025413368E-4,3.035196512491723,0.03692399477202193,1.4326913191956054,195]
["High","Q13367","AP-3 complex subunit beta-2 [OS=Homo sapiens]",23,20,42,15,1082,119,5.59,85.06,"transport","other membranes;ER/Golgi;other cell component","","AP3B2","ENSG00000103723","","","Lysosome",1134.3,1066.7,1094.8,942.7,991.9,977.3,1.1318383186235794,0.1786678861032137,0.006356671069954005,2.1967702608363107,0.08383933735506903,1.076552162900595,592]
["High","Q13418","Integrin-linked protein kinase [OS=Homo sapiens]",24,12,25,12,452,51.4,8.07,41.21,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ILK","ENSG00000166333","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; PPAR signaling pathway; Eukaryotic transcription initiation; Endometrial cancer; Acute viral myocarditis; Genes controlling nephrogenesis; Development of ureteric collection system","Localization of the PINCH-ILK-PARVIN complex to focal adhesions","PPAR signaling pathway; Axon guidance; Focal adhesion; Bacterial invasion of epithelial cells; Shigellosis; Endometrial cancer",1284.5,1224.7,1280,1250.4,1184.9,1204,1.041189239688951,0.0582323072046387,0.14170861300167367,0.8486037526782867,0.37142022501412153,0.43013445123469496,2979]
["High","Q13435","Splicing factor 3b subunit 2 [OS=Homo sapiens]",49,43,282,43,895,100.2,5.67,582.83,"RNA metabolism OR transcription;other metabolic processes","nucleus","","SF3B2","ENSG00000087365","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",11663.2,12619.4,10577.6,12136,11089.1,11247.6,1.0112407789352154,0.016126547406709674,0.8573165525954426,0.06685879107384461,0.9212672230477864,0.035614379941905076,7266]
["High","Q13438-1","Protein os-9 [OS=Homo sapiens]",35,22,48,22,667,75.5,4.87,78.4,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;ER/Golgi","other molecular function","OS9","ENSG00000135506","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",1569.3,1183,1489.8,1343.4,1285,1272,1.087606399343657,0.12115654514228207,0.39558099716316825,0.40276457912085706,0.6241051577793529,0.2047422282733779,4949]
["High","Q13464","Rho-associated protein kinase 1 [OS=Homo sapiens]",27,35,47,31,1354,158.1,5.9,89.19,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function","ROCK1","ENSG00000067900","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; G13 signaling pathway","Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse; EPHB-mediated forward signaling; RND3 GTPase cycle; RHOBTB1 GTPase cycle; Potential therapeutics for SARS; VEGFA-VEGFR2 Pathway; Apoptotic cleavage of cellular proteins; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; RHOH GTPase cycle","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; TGF-beta signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer",2254.8,2079.1,2091.4,2247.5,2174.3,2067.3,0.9901681280917229,-0.014254582856568762,0.7963418760867645,0.09890044605294636,0.8859842360338356,0.05257400527369828,7018]
["High","Q13492-1","Phosphatidylinositol-binding clathrin assembly protein [OS=Homo sapiens]",18,10,25,9,652,70.7,7.9,40.14,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PICALM","ENSG00000073921","","Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; RND3 GTPase cycle","",890.2,771.5,876.3,862,890.6,867.9,0.9685174585002863,-0.04615003979680971,0.5141727917626502,0.2888909084399083,0.7056883737181882,0.15138703754904445,5689]
["High","Q13501-1","sequestosome-1 [OS=Homo sapiens]",58,14,59,14,440,47.7,5.22,141.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","SQSTM1","ENSG00000161011","IL-1 signaling pathway; RANKL/RANK signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Interleukin-1 induced activation of NF-kB; Clear cell renal cell carcinoma pathways; CAMKK2 pathway; 7q11.23 copy number variation syndrome","Interleukin-1 signaling; Signaling by ALK fusions and activated point mutants; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; PINK1-PRKN Mediated Mitophagy; NRIF signals cell death from the nucleus; Pexophagy","Mitophagy; Autophagy; Necroptosis; Cellular senescence; Osteoclast differentiation; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Shigellosis; Fluid shear stress and atherosclerosis",2287.3,2874.1,2343,1414.1,1411,1386.8,1.781713715900188,0.8332655445864378,0.004226281827499774,2.3740415456067185,0.06846225831767269,1.1645487791869324,482]
["High","Q13555-8","Isoform 8 of Calcium/calmodulin-dependent protein kinase type II subunit gamma [OS=Homo sapiens]",22,9,21,7,556,62.1,7.42,36.99,"protein metabolism;other metabolic processes;other biological processes","other cell component","kinase activity;other molecular function","CAMK2G; LOC111145432","ENSCATG00000041481; ENSECAG00000000031; ENSFCAG00000018407; ENSG00000148660; ENSLCNG00005022562; ENSMPUG00000003376; ENSPANG00000022457; ENSPTRG00000002643","Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway; Calcium regulation in cardiac cells","","ErbB signaling pathway; Calcium signaling pathway; cAMP signaling pathway; HIF-1 signaling pathway; Oocyte meiosis; Necroptosis; Adrenergic signaling in cardiomyocytes; Wnt signaling pathway; Axon guidance; Circadian entrainment; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Dopaminergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Melanogenesis; Oxytocin signaling pathway; Glucagon signaling pathway; Aldosterone synthesis and secretion; Cushing syndrome; Gastric acid secretion; Parkinson disease; Pathways of neurodegeneration; Amphetamine addiction; Tuberculosis; Pathways in cancer; Proteoglycans in cancer; Glioma; Diabetic cardiomyopathy; Lipid and atherosclerosis",854.6,783.4,811.5,761.5,799.2,791.3,1.041454081632653,0.05859923144648658,0.24174854007157384,0.6166361399575727,0.4893887998130279,0.31034597416497917,3857]
["High","Q13573","SNW domain-containing protein 1 [OS=Homo sapiens]",19,10,17,10,536,61.5,9.52,28.8,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SNW1","ENSG00000100603","TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; mRNA Splicing - Major Pathway; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling","Spliceosome; Notch signaling pathway; Epstein-Barr virus infection; Viral carcinogenesis",592.3,524.6,523.9,1244.7,647.7,493.2,0.6877934272300471,-0.53995276580359,0.34161165590593645,0.4664673194547287,0.5818725587507748,0.2351721237554269,4584]
["High","Q13574","Diacylglycerol kinase zeta [OS=Homo sapiens]",13,10,17,10,1117,124.1,9.04,42.38,"","","","","","","","",589.3,592.2,662.9,626.5,626,621.7,0.9840998826165832,-0.02312334350725457,0.7014928766580226,0.15397673467670556,0.8291335726530186,0.08137549937346557,6606]
["High","Q13615","myotubularin-related protein 3 [OS=Homo sapiens]",4,4,4,4,1198,133.5,5.8,7.86,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;other cell component","other molecular function","MTMR3","ENSG00000100330","","Synthesis of PIPs at the plasma membrane; Macroautophagy","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Autophagy",223,236.4,170.3,180,157.3,185.4,1.2047063325043046,0.2686815080534179,0.17926378885796754,0.7465074287167414,0.4189439279865341,0.3778440996962372,3341]
["High","Q13636","ras-related protein rab-31 [OS=Homo sapiens]",17,3,4,3,194,21.6,7.06,11.98,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB31","ENSG00000168461","","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","Endocytosis",263.4,306.8,283.6,280.2,280.9,245.1,1.0590424212354257,0.08276037939655935,0.40923916248726533,0.3880228127939659,0.6352563381114449,0.19705099319125785,5030]
["High","Q13637","Ras-related protein Rab-32 [OS=Homo sapiens]",9,2,2,2,225,25,6.54,5.58,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB32","ENSG00000118508","","RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","",158.2,182.1,172.8,183.5,180.6,177.7,0.9470284237726097,-0.0785203680105987,0.2521386036907384,0.5983606565592859,0.49954281086457386,0.30142728676625363,3941]
["High","Q13794","phorbol-12-myristate-13-acetate-induced protein 1 [OS=Homo sapiens]",41,2,3,2,54,6,10.29,7.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus","","PMAIP1","ENSG00000141682","miRNA regulation of DNA damage response; TP53 network; Apoptosis modulation and signaling; Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; miRNA regulation of p53 pathway in prostate cancer; Chromosomal and microsatellite instability in colorectal cancer ; Unfolded protein response; p53 transcriptional gene network; DNA damage response; DNA damage response (only ATM dependent)","TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation of NOXA and translocation to mitochondria","Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Pathways in cancer; Viral carcinogenesis; Colorectal cancer",98.1,128.3,110.1,82.4,74.5,78.4,1.4300892477688059,0.516105184273382,0.02049140219753991,1.6884283224275856,0.1522329860688788,0.8174912337971925,1051]
["High","Q13838-1","spliceosome RNA helicase DDX39B [OS=Homo sapiens]",60,24,220,12,428,49,5.67,471.31,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BAT1; DDX39B; LOC101341139","ENSANAG00000030372; ENSCANG00000041217; ENSCCAG00000027897; ENSCJAG00000003152; ENSECAG00000007750; ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439; ENSGGOG00000005989; ENSMFAG00000034233; ENSMICG00000017349; ENSMLEG00000043791; ENSMMUG00000008839; ENSMNEG00000041059; ENSMODG00000015791; ENSOANG00000008361; ENSPANG00000018609; ENSPCOG00000018656; ENSPCTG00005013682; ENSPPAG00000043072; ENSPPYG00000016433; ENSPTRG00000032509; ENSRROG00000039517; ENSSHAG00000003209; ENSSSCG00000001400; ENSSSCG00005031872; ENSSSCG00015055352; ENSSSCG00025077755; ENSSSCG00030066086; ENSSSCG00035021438; ENSSSCG00040071129; ENSSSCG00045038130; ENSSSCG00050005792; ENSSSCG00055028973; ENSSSCG00060042375; ENSSSCG00065025136; ENSSSCG00070024145; ENSVURG00010001931","","Transport of Mature mRNA derived from an Intron-Containing Transcript; RHOBTB2 GTPase cycle; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",8959.2,7493.4,9119.7,8848.6,9755.1,9439.4,0.9118927650652033,-0.1330639156780081,0.22971951827202539,0.6388021031170618,0.4745105816581942,0.3237540982956517,3780]
["High","Q13884","Beta-1-syntrophin [OS=Homo sapiens]",2,1,1,1,538,58,8.63,2.76,"other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SNTB1","ENSG00000172164","IL-18 signaling pathway","","",42.9,40.7,43.6,42.1,41.1,45.3,0.9898832684824902,-0.014669688796885204,0.7922092310697059,0.10116010136712333,0.8839053552718296,0.05359423485537559,6998]
["High","Q13952-1","Nuclear transcription factor Y subunit gamma [OS=Homo sapiens]",11,5,13,5,458,50.3,6.1,18.92,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFYC","ENSG00000066136","","PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum  stress; ATF6 (ATF6-alpha) activates chaperone genes","Antigen processing and presentation; Tuberculosis",556.8,544.8,556.2,590.7,533,542.5,0.9949585884047534,-7.291615006354152E-3,0.8856995915619696,0.05271355559591017,0.9368114888805011,0.02834779179691311,7382]
["High","Q14011","Cold-inducible RNA-binding protein [OS=Homo sapiens]",46,7,37,2,172,18.6,9.51,75.64,"cell organization and biogenesis;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CIRBP","ENSG00000099622","","","",2009.2,1974.1,1798.8,1402.9,1329.4,1408,1.3965413134313938,0.4818582530313836,1.4335073058961126E-3,2.8436000893221136,0.04304932709398787,1.3660336326342961,260]
["High","Q14108-1","Lysosome membrane protein 2 [OS=Homo sapiens]",13,6,21,6,478,54.3,5.14,38.78,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCARB2","ENSG00000138760","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome","Cargo recognition for clathrin-mediated endocytosis","Lysosome",861.5,865.1,1026.4,870.5,874.9,869.5,1.0528127270641325,0.07424883449860299,0.44510863455179495,0.35153398086502646,0.6564805853004184,0.18277811317172044,5294]
["High","Q14119","Vascular endothelial zinc finger 1 [OS=Homo sapiens]",11,5,10,3,521,56.9,9.52,26.17,"stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","VEZF1","ENSG00000136451","","","",86.4,101.1,85.6,75.8,81.5,81.3,1.1445934618608549,0.19483527107005816,0.09907745366577005,1.0040251635023851,0.31370509254758006,0.5034784311034626,2466]
["High","Q14155-1","Isoform 1 of Rho guanine nucleotide exchange factor 7 [OS=Homo sapiens]",24,15,41,12,646,73.1,7.21,77.89,"","","","ARHGEF7","","","","",1959.2,1773.6,1883.2,2139,2017.5,2096.7,0.8981001727115716,-0.1550517249607822,0.030238839987457827,1.5194348731149097,0.17927476281098764,0.7464808434180581,1317]
["High","Q14165","Malectin [OS=Homo sapiens]",41,13,56,13,292,32.2,5.41,127.57,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","MLEC","ENSG00000110917","","Neutrophil degranulation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle","",2857.5,2706.5,3197.9,2892.1,3176.5,2971.8,0.9691938409804874,-0.045142858087311014,0.6104001155237243,0.21438539285902253,0.7697035048464534,0.11367653587522328,6192]
["High","Q14185","Dedicator of cytokinesis protein 1 [OS=Homo sapiens]",9,13,21,13,1865,215.2,7.56,36.41,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DOCK1","ENSG00000150760","Integrin-mediated cell adhesion; Focal adhesion; Hepatocyte growth factor receptor signaling; Regulation of actin cytoskeleton","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; DCC mediated attractive signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases","Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection",717.6,608.8,689.2,627.6,666.2,651.1,1.036351483366754,0.05151338266793292,0.5316429192949463,0.2743799659148618,0.7166899022539609,0.14466871444531684,5792]
["High","Q14197","Peptidyl-tRNA hydrolase ICT1, mitochondrial [OS=Homo sapiens]",17,3,3,3,206,23.6,10.07,2.99,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL58","ENSG00000167862","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",17.2,32.7,21.9,32.2,24.7,23.3,0.8952618453865338,-0.15961839263186883,0.6287605652812814,0.20151470427429138,0.7811237062396572,0.10728018163763253,6285]
["High","Q14247-1","Src substrate cortactin [OS=Homo sapiens]",52,29,112,29,550,61.5,5.4,244.18,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CTTN","ENSG00000085733; ENSG00000288401","Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma","Clathrin-mediated endocytosis; RHO GTPases activate PAKs","Tight junction; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Proteoglycans in cancer",5978.3,6834.3,5629.3,6743.4,5974.3,6198.9,0.9749056384339682,-0.03666550838556019,0.7282989973970935,0.13769028791090815,0.8449566971287527,0.07316554747624965,6730]
["High","Q14315","Filamin-C [OS=Homo sapiens]",65,139,716,120,2725,290.8,5.97,1666.9,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","FLNC","ENSG00000128591","Focal adhesion; MAPK signaling pathway; Ebola virus infection in host","Cell-extracellular matrix interactions","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer",41975.7,56663.4,41897.2,16614.4,16484.9,16742.9,2.8196247356657604,1.4955031668725056,3.5298562622526493E-3,2.452242978969537,0.06335889125441077,1.198192431265539,435]
["High","Q14332","Frizzled-2 [OS=Homo sapiens]",2,2,2,1,565,63.5,8.1,3.91,"cell-cell signaling;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","FZD2","ENSG00000180340","MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Asymmetric localization of PCP proteins; Ca2+ pathway; Class B/2 (Secretin family receptors); Disassembly of the destruction complex and recruitment of AXIN to the membrane","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",92.6,107.1,66.1,81.8,63.2,80.2,1.1802841918294846,0.2391342771959446,0.36957989283815657,0.4322916647976477,0.6028159187968093,0.21981528762096092,4787]
["High","Q14457","Beclin-1 [OS=Homo sapiens]",18,9,12,9,450,51.9,4.89,21.14,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BECN1","ENSG00000126581","Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; Malignant pleural mesothelioma; Alzheimer's disease","Ub-specific processing proteases; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Autophagy; Mitophagy; Autophagy; Apoptosis; Apelin signaling pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Kaposi sarcoma-associated herpesvirus infection",508.1,461,480.6,485.1,478.1,462.6,1.0167625192874175,0.02398275465810094,0.6277173149978845,0.20223589157500058,0.7806971639859003,0.10751739828038884,6278]
["High","Q14527","Helicase-like transcription factor [OS=Homo sapiens]",31,25,42,25,1009,113.9,8.6,87.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HLTF","ENSG00000071794","Retinoblastoma gene in cancer","E3 ubiquitin ligases ubiquitinate target proteins","",1946.2,1617.6,1986.9,2397.4,2379.6,2500.9,0.7626787947072645,-0.3908525068326853,0.009408462924590301,2.0264813221513336,0.10585198633314276,0.9753009879475533,694]
["High","Q14596-1","Next to BRCA1 gene 1 protein [OS=Homo sapiens]",7,4,6,4,966,107.3,5.12,13.95,"other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NBR1","ENSG00000188554","","Pexophagy","Mitophagy",167.8,145.7,183,197,178.4,181,0.8923436376707404,-0.16432870212650294,0.17960854844286744,0.7456729969937932,0.4193730700484178,0.37739946110213657,3344]
["High","Q14657","EKC/KEOPS complex subunit LAGE3 [OS=Homo sapiens]",21,2,5,2,143,14.8,8.63,9.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","LAGE3","ENSG00000196976","","tRNA modification in the nucleus and cytosol","",68.3,137.5,125,138.8,92.7,104.1,0.9856972586412395,-0.020783481268548697,0.9528074142967218,0.020994872037846904,0.9742692890032483,0.011320987100840667,7636]
["High","Q14671-3","Isoform 3 of Pumilio homolog 1 [OS=Homo sapiens]",21,22,57,1,1188,126.6,6.84,117.66,"","","","PUM1","","","","",10.5,5.8,14.6,11.2,18.2,9.1,0.8025974025974025,-0.3172516076778893,0.5359317282426036,0.2708905310832943,0.7192428556408128,0.1431244433356993,5818]
["High","Q14681","BTB/POZ domain-containing protein KCTD2 [OS=Homo sapiens]",24,3,6,2,263,28.5,5.29,11.77,"cell organization and biogenesis;protein metabolism;other metabolic processes","other cell component","other molecular function","KCTD2","ENSG00000180901","","","",20.9,47.5,25.6,24.8,15.2,19.8,1.57190635451505,0.6525152723668945,0.25805512537468633,0.5882875107469505,0.504986069906153,0.29672060177506343,3990]
["High","Q14691","DNA replication complex GINS protein PSF1 [OS=Homo sapiens]",40,6,16,6,196,23,7.39,36.45,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;developmental processes","nucleus;other cell component","","GINS1","ENSG00000101003","","Unwinding of DNA","",496,575.7,591.5,612.4,603.1,569.7,0.9316603181716333,-0.10212404839348539,0.27613655552506056,0.5588760967583072,0.5231919984323399,0.2813389066242601,4121]
["High","Q14697-2","Isoform 2 of Neutral alpha-glucosidase AB [OS=Homo sapiens]",61,47,354,1,966,109.4,6.24,762.7,"","","","GANAB","","","","",779.2,740.3,728,766.9,703,740.2,1.0169223112076373,0.02420946728130875,0.6324219900047077,0.1989930375828626,0.7838017298344059,0.10579378237780895,6300]
["High","Q14739","Lamin-B receptor [OS=Homo sapiens]",24,17,59,17,615,70.7,9.36,103.64,"other metabolic processes;developmental processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","LBR","ENSG00000143815","Gastric cancer network 2; ATM signaling in development and disease ; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias","RHOC GTPase cycle; RHOA GTPase cycle; RHOD GTPase cycle; Regulation of MECP2 expression and activity; CDC42 GTPase cycle; RAC1 GTPase cycle; Cholesterol biosynthesis; Initiation of Nuclear Envelope (NE) Reformation; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","Steroid biosynthesis; Metabolic pathways",3261.5,3500.6,3366.3,3558.2,3516.3,3486.3,0.9590561321112039,-0.06031283840458284,0.11686577903170824,0.9323126415622431,0.33984655593280366,0.4687171269391822,2685]
["High","Q14790-4","Isoform 4 of Caspase-8 [OS=Homo sapiens]",20,6,8,6,496,57.7,5.43,17.84,"","","","CASP8","","","","",309.5,289.3,285.8,324.8,318.5,326.5,0.912146834398845,-0.13266201149767667,0.021733456169272095,1.662871204379477,0.15468990498603147,0.8105380272955529,1097]
["High","Q14894","Ketimine reductase mu-crystallin [OS=Homo sapiens]",26,6,9,6,314,33.8,5.14,14.17,"other metabolic processes;transport;other biological processes","cytosol;other cytoplasmic organelle;other cell component","other molecular function","CRYM","ENSG00000103316","","Lysine catabolism","",339.4,367.8,378.9,304.7,341.1,345.9,1.0951900776444488,0.13118128103825868,0.1472010791696967,0.8320890060601618,0.37832324758294666,0.42213697092829394,3038]
["High","Q14974","Importin subunit beta-1 [OS=Homo sapiens]",54,37,300,37,876,97.1,4.78,636.72,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","KPNB1","ENSG00000108424","Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome","Neutrophil degranulation; Assembly of the ORC complex at the origin of replication; Apoptosis induced DNA fragmentation; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Regulation of cholesterol biosynthesis by SREBP (SREBF); Initiation of Nuclear Envelope (NE) Reformation; Postmitotic nuclear pore complex (NPC) reformation; Inhibition of nitric oxide production","Nucleocytoplasmic transport; Chemical carcinogenesis",10733.5,9707.2,10715.5,10389.1,10714.7,10753.1,0.978004765058747,-0.03208660055865013,0.5499967925946015,0.2596398431648969,0.7295913959528796,0.1369202962698536,5886]
["High","Q14BN4","Sarcolemmal membrane-associated protein [OS=Homo sapiens]",22,18,27,18,828,95.1,5.47,58.18,"other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","SLMAP","ENSG00000163681","","","",972,788.9,982.4,1016.9,995.4,1015,0.906187031348066,-0.14211925063031294,0.2085954068841972,0.6806952586458703,0.45041840070570016,0.34638387579056057,3616]
["High","Q15006","ER membrane protein complex subunit 2 [OS=Homo sapiens]",34,9,37,9,297,34.8,6.57,77.06,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC2","ENSG00000104412","","","",811.8,802.7,896.7,829.8,855.8,843.3,0.993000909486338,-0.010133055773361979,0.857688796091723,0.06667026303336776,0.9211601265315232,0.035664869233770144,7270]
["High","Q15007","Pre-mRNA-splicing regulator WTAP [OS=Homo sapiens]",32,10,23,10,396,44.2,5.19,66.49,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","WTAP","ENSG00000146457","","Processing of Capped Intron-Containing Pre-mRNA","",902.6,731.4,885.5,826.8,816.9,835.4,1.016296236537453,0.023320989403266598,0.8176601869047265,0.08742714817981392,0.8985630878750323,0.04645142578466712,7105]
["High","Q15022","Polycomb protein suz12 [OS=Homo sapiens]",13,7,11,7,739,83,8.81,21.89,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","SUZ12","ENSG00000178691","Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma","HCMV Early Events; Defective pyroptosis; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines","",318.1,248.5,327.8,382.3,412.4,392.3,0.753496208930076,-0.4083278416860787,0.02118446329216961,1.6739825343630983,0.1532977658806861,0.8144641743873736,1079]
["Medium","Q15035","Translocating chain-associated membrane protein 2 [OS=Homo sapiens]",2,1,1,1,370,43.3,9.22,1.96,"cell organization and biogenesis;other metabolic processes;transport","other membranes;ER/Golgi","","TRAM2","ENSG00000065308","","","",53.4,100.6,46,54.5,56,60.8,1.1675423234092237,0.22347484857808825,0.6078356929555604,0.21621380113250532,0.7684554874671333,0.11438128380154967,6176]
["High","Q15047","Histone-lysine N-methyltransferase SETDB1 [OS=Homo sapiens]",16,19,52,19,1291,143.1,6.02,98.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETDB1","ENSG00000143379","Histone modifications; Malignant pleural mesothelioma","PKMTs methylate histone lysines","Lysine degradation; Metabolic pathways; Signaling pathways regulating pluripotency of stem cells",1910.7,1722.3,1883.7,2292.7,2356.4,2292.2,0.7947646694423234,-0.3314003546013335,1.6160865487344857E-3,2.791535384507416,0.04571885424825675,1.3399046619139983,276]
["High","Q15054","DNA polymerase delta subunit 3 [OS=Homo sapiens]",23,11,24,11,466,51.4,9.35,42.02,"DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","POLD3","ENSG00000077514","Homologous recombination; Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Dual Incision in GG-NER; Termination of translesion DNA synthesis; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)","DNA replication; Base excision repair; Nucleotide excision repair; Mismatch repair; Homologous recombination",978.5,1003.4,971.1,1108.4,1118.9,1090.8,0.8899671498749283,-0.16817601002989271,6.7351371983804533E-4,3.1716535530378525,0.03266332375463017,1.4859396244110668,161]
["High","Q15070-1","Mitochondrial inner membrane protein OXA1L [OS=Homo sapiens]",11,5,7,5,435,48.5,9.45,14.77,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;other cell component","translation activity;other molecular function","OXA1L","ENSG00000155463","","Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination","Protein export",460,424.3,517.1,611.4,585.6,572.7,0.7918856303328249,-0.3366360136561587,0.013842343840524221,1.8587903671897816,0.1259685556023463,0.8997378503798517,858]
["Medium","Q15121","Astrocytic phosphoprotein PEA-15 [OS=Homo sapiens]",8,1,1,1,130,15,5.02,2.31,"transport;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus","","PEA15","ENSG00000162734","Apoptosis modulation and signaling","RAF/MAP kinase cascade; RAF-independent MAPK1/3 activation","",83.1,104.9,100.9,104.5,87.7,95.5,1.0041710114702815,0.00600498282532848,0.9637579668819279,0.016032018841315172,0.9803311888241393,0.008627180246113714,7676]
["High","Q15149-3","Isoform 3 of Plectin [OS=Homo sapiens]",41,185,463,1,4570,517.7,5.74,980.82,"","","","PLEC","","","","",12.9,10.4,14.1,14,14.6,13.8,0.8820754716981132,-0.18102599467556257,0.2096360763402949,0.6785339773786476,0.45154165077655795,0.3453021836270247,3625]
["High","Q15172-1","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [OS=Homo sapiens]",5,2,2,2,486,56.2,6.71,3.11,"protein metabolism;other metabolic processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP2R5A","ENSG00000066027; ENSGGOG00000014986; ENSNLEG00000002787; ENSPPAG00000015631; ENSPPYG00000000237; ENSPTRG00000001958","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; Glycogen metabolism","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Separation of Sister Chromatids; RAF activation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; Dopaminergic synapse; Human papillomavirus infection",61.3,39.2,59.2,64.7,81.3,66.5,0.7515294117647059,-0.41209852850119383,0.11580635847732755,0.9362675945308193,0.33840420920320863,0.47056424367569205,2672]
["High","Q15233","Non-POU domain-containing octamer-binding protein [OS=Homo sapiens]",58,27,490,25,471,54.2,8.95,715.13,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","NONO","ENSG00000147140","mRNA processing","","",12836.2,13570.7,12713,13086.9,13434.7,13453.3,0.9786115787656756,-0.031191742293195827,0.3858664103385517,0.4135630251070993,0.6152429920203005,0.210953324466682,4897]
["High","Q15283-1","ras GTPase-activating protein 2 [OS=Homo sapiens]",8,6,6,6,850,96.6,7.2,14.19,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;other molecular function","RASA2","ENSG00000155903","MAPK signaling pathway; Ebola virus infection in host; Ras signaling; Modulators of TCR signaling and T cell activation","Regulation of RAS by GAPs","MAPK signaling pathway; Ras signaling pathway; Viral carcinogenesis",350.8,294.3,382,358,383.1,339.9,0.9501387604070305,-0.07378987162023998,0.5634161155469516,0.24917073492742448,0.7391050117927752,0.13129385280661135,5952]
["High","Q15365","Poly(RC)-binding protein 1 [OS=Homo sapiens]",84,18,347,12,356,37.5,7.09,948.55,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCBP1","ENSG00000169564","Ferroptosis","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Spliceosome; Ferroptosis",9547.2,8181.5,9842.2,10058.1,9812.8,10007,0.9227857379534706,-0.11593238816035896,0.21108935659232692,0.675533663848915,0.45292269751934283,0.34397591477651507,3639]
["High","Q15366-1","Poly(rC)-binding protein 2 [OS=Homo sapiens]",65,16,384,1,365,38.6,6.79,990.65,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101348589; Pcbp2; PCBP2","ENSBIXG00000004442; ENSCAFG00000006821; ENSG00000197111; ENSRNOG00000036852","mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation","mRNA Splicing - Major Pathway; Negative regulators of DDX58/IFIH1 signaling; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway","Ferroptosis",326,309.7,358.4,319.2,315.2,316.4,1.0455405973916703,0.06424908155304723,0.3717515183393255,0.42974724901974287,0.6047158031653028,0.2184486817366947,4800]
["High","Q15390","Mitochondrial fission regulator 1 [OS=Homo sapiens]",9,3,6,3,333,37,9.01,10.91,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;mitochondrion","","MTFR1","ENSG00000066855","","","",267,287.9,265.7,299.5,283.8,282.1,0.9482320314305523,-0.0766879665293562,0.175325791421095,0.7561541920182934,0.4143292310580841,0.3826544260080026,3304]
["High","Q15427","Splicing factor 3b subunit 4 [OS=Homo sapiens]",27,8,35,8,424,44.4,8.56,70.93,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","SF3B4","ENSG00000143368","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",1021.4,1018.8,1029.1,1097.1,1064.2,1072.6,0.9491017038251027,-0.07536540306530094,0.006066471364698333,2.217063848042134,0.08237740594011232,1.0841918880731292,575]
["High","Q15438-1","Cytohesin-1 [OS=Homo sapiens]",14,3,3,2,398,46.4,5.54,9.12,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CYTH1","ENSCATG00000038229; ENSG00000108669; ENSMFAG00000037544; ENSMMUG00000013313; ENSPANG00000019854; ENSPTRG00000009717","","Intra-Golgi traffic","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection",23.7,27.7,15,19.7,23.9,17,1.0957095709570959,0.13186544787397406,0.6729577253464804,0.17201221694304386,0.8107474031021938,0.0911144337375595,6481]
["High","Q15542","Transcription initiation factor TFIID subunit 5 [OS=Homo sapiens]",24,11,28,11,800,86.8,5.64,63.38,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","TAF5","ENSG00000148835","Eukaryotic transcription initiation","Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors",597.9,508.1,598.2,631.1,647,632,0.8922045966179782,-0.16455351402438462,0.08707249715334635,1.060119000224452,0.29444004234444704,0.5310031284829931,2309]
["High","Q15560","transcription elongation factor A protein 2 [OS=Homo sapiens]",25,6,17,4,299,33.6,9.13,31.02,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","TCEA2","ENSG00000171703","","","",133.6,148.9,136.1,127.4,124,131.7,1.092665100495954,0.1278512858318291,0.08668917673079214,1.0620351214339645,0.293525191636611,0.5323546197340094,2306]
["Medium","Q15573-1","TATA box-binding protein-associated factor RNA polymerase I subunit A [OS=Homo sapiens]",2,1,1,1,450,52.6,9.1,2.59,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus","nucleic acid binding activity","TAF1A","ENSG00000143498","","RNA Polymerase I Transcription Initiation; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; SIRT1 negatively regulates rRNA expression; RNA Polymerase I Transcription Termination","",26,13.9,25.1,30,18.3,29,0.8408796895213455,-0.2500286960090304,0.4900426211251383,0.3097661458602941,0.6905347023542826,0.16081449136156256,5541]
["High","Q15637-5","Isoform 5 of Splicing factor 1 [OS=Homo sapiens]",25,13,62,13,673,71.7,9.58,126.09,"","","","SF1","","","","",2918.5,3465.7,2799.9,3328.5,2928.4,3061.9,0.9855453491865906,-0.021005837478230406,0.8585996604906612,0.06620928758621146,0.9213779754138376,0.03556217331902202,7276]
["High","Q15678","Tyrosine-protein phosphatase non-receptor type 14 [OS=Homo sapiens]",9,7,12,7,1187,135.2,8.31,17.6,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN14","ENSG00000152104","VEGFA-VEGFR2 signaling pathway","Interleukin-37 signaling","",241.2,163.3,241.7,218.8,241.1,215,0.9574751815083716,-0.06269300312793345,0.7436292916951106,0.128643511623373,0.8537358490744632,0.0686764818109174,6801]
["High","Q15723-1","Isoform 1 of ETS-related transcription factor Elf-2 [OS=Homo sapiens]",3,1,1,1,581,62.7,6.7,2.61,"","","","ELF2","","","","",29.8,38.8,39.6,38.2,33.8,27.8,1.0841683366733466,0.11658877848955454,0.5551616084737802,0.25558057462179706,0.7330799660008922,0.13484864896226728,5913]
["High","Q15751","Probable E3 ubiquitin-protein ligase HERC1 [OS=Homo sapiens]",3,10,12,10,4861,531.9,6.04,18.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","HERC1","ENSG00000103657","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",275.1,256.3,281.2,277.6,274.2,275.8,0.9818753020782991,-0.026388280628920964,0.5443865362805745,0.26409262426840574,0.7251057787920038,0.13959863371218706,5862]
["High","Q15800","Methylsterol monooxygenase 1 [OS=Homo sapiens]",9,2,7,2,293,35.2,7.23,14.11,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","MSMO1","ENSG00000052802","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Cholesterol biosynthesis","Steroid biosynthesis; Metabolic pathways",326.4,267.6,375,369.6,429,424.7,0.7921196762854574,-0.3362096805671854,0.08073879765974,1.0929177222730946,0.2835845848525641,0.5473173803134497,2223]
["High","Q15811-7","Isoform 7 of Intersectin-1 [OS=Homo sapiens]",33,30,62,29,1215,137,7.33,118.38,"","","","ITSN1","","","","",2140,2007.2,2057.2,2437.7,2291,2309.8,0.8814946366413299,-0.18197630323696545,0.009890097618716044,2.0047994217435203,0.10907045509454079,0.9622928747746539,708]
["High","Q15942","Zyxin [OS=Homo sapiens]",35,12,44,12,572,61.2,6.67,85.33,"cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","ZYX","ENSG00000159840; ENSG00000285443","Integrin-mediated cell adhesion; Focal adhesion","","Focal adhesion",959.9,1140.7,885.6,1042.3,771.7,700.1,1.1877809156358141,0.24826875779402752,0.2889532734367466,0.5391723812202204,0.5327384082630738,0.27348599122831063,4235]
["High","Q16143","Beta-synuclein [OS=Homo sapiens]",30,4,13,1,134,14.3,4.41,31.63,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","cytosol;other cell component","enzyme regulator activity;other molecular function","SNCB","ENSG00000074317","","MTF1 activates gene expression","",188.9,199.5,197.9,208.8,187.4,185.1,1.0086014106313435,0.012356148164587015,0.8495016728452734,0.07083576157803621,0.9167807963477395,0.0377344923744571,7235]
["High","Q16513","Serine/threonine-protein kinase N2 [OS=Homo sapiens]",18,14,30,10,984,112,6.3,68.68,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","PKN2","ENSG00000065243","PI3K-Akt signaling pathway","RAC1 GTPase cycle; RHO GTPases activate PKNs; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle","PI3K-Akt signaling pathway; NOD-like receptor signaling pathway; Yersinia infection",476.2,412.9,433.1,449.1,465.6,483.5,0.9456443999427835,-0.08063032029252223,0.29703538764462084,0.5271918074394584,0.5413754217388421,0.2665014649406409,4284]
["High","Q16539-2","Isoform CSBP1 of Mitogen-activated protein kinase 14 [OS=Homo sapiens]",28,8,23,1,360,41.5,5.88,39.57,"","","","MAPK14","","","","",24.2,23.3,18.1,17.4,19.8,21.7,1.1137521222410862,0.15542818078762252,0.38127977175045,0.41875623498384895,0.6118028067874053,0.2133885349200132,4866]
["High","Q16566","calcium/calmodulin-dependent protein kinase type IV [OS=Homo sapiens]",7,3,5,3,473,51.9,5.82,11.99,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","CAMK4","ENSG00000152495","Energy metabolism; Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway; Common pathways underlying drug addiction; Mitochondrial gene expression; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; CAMKK2 pathway; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells","Transcriptional activation of mitochondrial biogenesis; Regulation of MECP2 expression and activity; Negative regulation of NMDA receptor-mediated neuronal transmission; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; Loss of phosphorylation of MECP2 at T308","Calcium signaling pathway; cAMP signaling pathway; Longevity regulating pathway; Apelin signaling pathway; Osteoclast differentiation; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Oxytocin signaling pathway; Aldosterone synthesis and secretion; Amphetamine addiction; Alcoholism; Glioma",212.5,214.5,191.7,204.2,204.8,203.2,1.0106174452793204,0.015236989086645381,0.7815198502000998,0.1070599866494203,0.8766135598854158,0.057191815751573345,6961]
["High","Q16629","serine/arginine-rich splicing factor 7 [OS=Homo sapiens]",35,12,87,11,238,27.4,11.82,155.06,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","other molecular function","SRSF7","ENSG00000115875","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection",3811.3,6300.8,3584.5,3881,3677.7,3889.8,1.1963663362012493,0.25865922105402084,0.4390042418381417,0.357531283407086,0.6535262383741106,0.1847369712780273,5245]
["High","Q16658","Fascin [OS=Homo sapiens]",68,33,275,33,493,54.5,7.24,687.19,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","FSCN1","ENSG00000075618","VEGFA-VEGFR2 signaling pathway","Interleukin-4 and Interleukin-13 signaling","MicroRNAs in cancer",8765.4,8483.2,9164.8,7902.8,8825.2,8387.5,1.0516772510999182,0.07269202432741666,0.2621849896665833,0.5813921756954292,0.5075974211050539,0.2944805930444125,4033]
["High","Q16698","2,4-dienoyl-CoA reductase, mitochondrial [OS=Homo sapiens]",26,6,11,6,335,36,9.28,28.23,"other metabolic processes;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","DECR1","ENSG00000104325","Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway","mitochondrial fatty acid beta-oxidation of unsaturated fatty acids","",215.8,207.8,244.8,242.8,245.2,245.4,0.9113716934824109,-0.1338885326504777,0.12692471367420344,0.8964538076346336,0.3538122686069905,0.45122711179956637,2801]
["High","Q16774-1","guanylate kinase [OS=Homo sapiens]",21,4,11,4,197,21.7,6.55,26.05,"other metabolic processes;transport","cytosol;other cell component","kinase activity;other molecular function","GUK1","ENSG00000143774","","Interconversion of nucleotide di- and triphosphates; Abacavir metabolism","Purine metabolism; Metabolic pathways",683.2,642.6,735.6,663.7,643.8,613.6,1.0730310759460726,0.10169185844679268,0.20122877636587713,0.6963099136594425,0.4429642756878401,0.3536312974727498,3547]
["High","Q16799-1","Reticulon-1 [OS=Homo sapiens]",4,2,2,1,776,83.6,4.69,6.67,"developmental processes;other biological processes","other membranes;ER/Golgi","","RTN1","ENSG00000139970","","","",17.1,22.5,16.6,19.2,11,18.6,1.1516393442622952,0.20368898265803997,0.4895494503832,0.310203432678317,0.6902134540613987,0.1610165794292373,5538]
["Medium","Q16854","Deoxyguanosine kinase, mitochondrial [OS=Homo sapiens]",3,1,1,1,277,32,8.66,2.25,"protein metabolism;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","DGUOK","ENSG00000114956","","Purine salvage","Purine metabolism; Metabolic pathways",86.1,70.1,91.9,80.7,111.7,94.4,0.8650627615062761,-0.20912328880947387,0.30931722404588174,0.509595896033641,0.5522865047679498,0.25783556871986263,4373]
["High","Q1KMD3","heterogeneous nuclear ribonucleoprotein U-like protein 2 [OS=Homo sapiens]",55,37,154,37,747,85.1,4.91,356.2,"","nucleus","","HNRNPUL2","ENSG00000214753","","","",5941.8,5749.7,5774.9,5752.4,5765.3,6086.7,0.9921610506464293,-0.011353772551142984,0.7312321187120103,0.13594474086142513,0.846598514665388,0.07232249781947561,6744]
["High","Q2M1P5","Kinesin-like protein KIF7 [OS=Homo sapiens]",16,16,22,15,1343,150.5,6.79,36.2,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF7","ENSG00000166813","Hedgehog signaling pathway; Hedgehog signaling pathway; Ciliopathies","Hedgehog 'on' state; Hedgehog 'off' state","Hedgehog signaling pathway; Pathways in cancer; Basal cell carcinoma",771.6,727.8,782.6,743.2,633,700.9,1.0986471522796206,0.13572811659416678,0.13223701169755217,0.878646973546766,0.3596330851043147,0.44414036138463653,2871]
["High","Q2NKX8","Dna excision repair protein ercc-6-like [OS=Homo sapiens]",28,28,42,28,1250,141,5.31,93.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","ERCC6L","ENSG00000186871","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",1772,2089.2,1823.1,1774.6,1726.6,1788.9,1.0745165497816673,0.10368770343025314,0.2596107059191364,0.5856774019112139,0.5061274386558344,0.2957401176728349,4005]
["Low","Q2TAK8-1","PWWP domain-containing protein MUM1 [OS=Homo sapiens]",2,1,1,1,710,78.6,8.54,0,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","other molecular function","PWWP3A","ENSG00000160953","IL-18 signaling pathway","","",33.2,31.3,38.9,55.8,49.9,66.3,0.6011627906976744,-0.7341723792745256,0.012597151898220431,1.899727633827187,0.12038991679474312,0.9194098857009669,817]
["High","Q2TAZ0-1","Autophagy-related protein 2 homolog A [OS=Homo sapiens]",9,11,13,11,1938,212.7,5.88,25.74,"cell organization and biogenesis;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ATG2A","ENSG00000110046","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease","","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",275.9,254.4,266.8,260.8,234.5,235.3,1.0910210785655625,0.1256789748496445,0.1058453556516744,0.9753281934698041,0.3242214738831988,0.48915822428043626,2549]
["High","Q32P28-1","Prolyl 3-hydroxylase 1 [OS=Homo sapiens]",42,25,107,23,736,83.3,5.14,239.1,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","P3H1","ENSG00000117385","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",4403.5,4521.2,4298.9,4172.7,4011.6,4092.9,{"$f":"AVERAGE(T3522:V3522)/AVERAGE(W3522:Y3522)","v":1.0770859805167303},{"$f":"LOG(Z3522,2)","v":0.10713342046146387},{"$f":"TTEST(T3522:V3522,W3522:Y3522,2,2)","v":0.01641449545812676},{"$f":"-LOG10(AB3522)","v":1.784772461891023},{"$f":"AB3522*7808/AF3522","v":0.13736803916082932},{"$f":"-LOG10(AD3522)","v":0.8621143009788874},933]
["Low","Q3C1V8","Brain-specific homeobox protein homolog [OS=Homo sapiens]",6,1,1,1,233,25.9,7.5,0,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BSX","ENSG00000188909","","","",127.5,53,145.3,150.3,165.4,158.8,0.6866174920969441,-0.5424214833829542,0.15818356692228572,0.8008386356655619,0.3924681571430591,0.40619557392014677,3147]
["High","Q3KR37","GRAM domain-containing protein 1B [OS=Homo sapiens]",3,2,2,2,738,85.3,6.21,2.16,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","GRAMD1B","ENSG00000023171","Ectoderm differentiation","","",30.6,34.1,32.3,32.9,32.7,36.3,0.9519136408243378,-0.07109739909132344,0.3499190598466068,0.4560324011559446,0.587689399716564,0.23085214268039633,4649]
["High","Q3T8J9-1","GON-4-like protein [OS=Homo sapiens]",7,9,10,8,2241,248.5,5.01,14.2,"developmental processes;other biological processes","nucleus","other molecular function","GON4L","ENSG00000116580","","","",248.9,209.4,243.4,248.1,226.2,252,0.9661296984717059,-0.04971121764650889,0.6074800585408886,0.21646797387417385,0.7685036126194521,0.1143540866066491,6172]
["High","Q3YEC7-1","Rab-like protein 6 [OS=Homo sapiens]",24,15,40,15,729,79.5,5.22,51.27,"","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RABL6","ENSG00000196642","","","",1243.8,950.3,1209.8,1255.3,1166.6,1204.4,0.9386702699721479,-0.09130962861280952,0.48385924761191856,0.3152809542140974,0.6851601388019333,0.1642079113252169,5514]
["High","Q49A26-5","Isoform 5 of Putative oxidoreductase GLYR1 [OS=Homo sapiens]",39,11,34,2,472,51.5,8.27,60.96,"","","","","","","","",29.5,74.8,32,40.3,30.9,31.8,1.3233009708737866,0.404141224734629,0.500458770910934,0.3006316950146494,0.6960424088479824,0.15736429865443433,5614]
["High","Q4G0N4","NAD kinase 2, mitochondrial [OS=Homo sapiens]",6,2,4,2,442,49.4,8.18,10.44,"other metabolic processes","mitochondrion","kinase activity;other molecular function","NADK2","ENSG00000152620","","Nicotinate metabolism","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors",141,113.6,162,154.9,192.2,188.5,0.7778192681105303,-0.36249312128366373,0.09684799988189645,1.0139093439611337,0.3110609556058607,0.5071544981458341,2431]
["High","Q4G148-1","Glucoside xylosyltransferase 1 [OS=Homo sapiens]",13,5,12,5,440,50.5,8.65,15.35,"protein metabolism;other metabolic processes","other membranes","other molecular function","GXYLT1","ENSG00000151233","","","Other types of O-glycan biosynthesis",479.7,505,516.7,491,478,484.5,1.0329549363605093,0.0467773166353772,0.23887986495079924,0.6218204551445825,0.48648252100569656,0.3129327590279909,3834]
["High","Q4V328","GRIP1-associated protein 1 [OS=Homo sapiens]",57,35,105,35,841,95.9,5.11,236.5,"","","","","","","","",3631.6,2773.8,3441,3603.2,3139.5,3251.5,0.9852114226251225,-0.021494740224375707,0.8755510842215505,0.05771850983375337,0.9307423915046789,0.031170505301393262,7345]
["High","Q4ZIN3-1","Membralin [OS=Homo sapiens]",4,3,5,3,620,67.8,5.3,7.84,"stress response;other biological processes","other membranes;ER/Golgi","","TMEM259","ENSG00000182087","","","",307,240.2,312.8,268,235.4,243.5,1.151425893693935,0.20342156159479366,0.2100186947168043,0.6777420450233043,0.4516182782563503,0.3452284892775611,3631]
["High","Q53EP0","Fibronectin type III domain-containing protein 3B [OS=Homo sapiens]",6,5,8,5,1204,132.8,5.95,11.71,"","other membranes","","FNDC3B","ENSG00000075420","","","",108.3,147.7,122.3,131.4,125.6,112,{"$f":"AVERAGE(T3586:V3586)/AVERAGE(W3586:Y3586)","v":1.0252032520325205},{"$f":"LOG(Z3586,2)","v":0.03590996010161786},{"$f":"TTEST(T3586:V3586,W3586:Y3586,2,2)","v":0.8217028363920947},{"$f":"-LOG10(AB3586)","v":0.08528521390588305},{"$f":"AB3586*7808/AF3586","v":0.9009767935050521},{"$f":"-LOG10(AD3586)","v":0.04528639501704648},7121]
["High","Q53G59-1","Kelch-like protein 12 [OS=Homo sapiens]",20,8,12,7,568,63.2,5.44,18.03,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","KLHL12","ENSCANG00000030198; ENSCATG00000031800; ENSG00000117153; ENSGGOG00000009159; ENSMLEG00000023751; ENSMMUG00000017849; ENSMNEG00000042480; ENSPPAG00000041960; ENSPTRG00000001861; ENSRBIG00000033303; ENSRROG00000044766","","Degradation of DVL","",360.9,336.7,361.8,354.1,358.2,353,0.99446165399418,-0.008012352444742256,0.8258068248963316,0.08312153221141565,0.9034467827925678,0.044097424309708956,7137]
["Medium","Q53HI1","protein unc-50 homolog [OS=Homo sapiens]",2,1,2,1,259,30.4,9.47,4.67,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity","UNC50","ENSG00000115446","","","",155.5,163.8,177,227.7,240.7,231.9,0.7086962730258461,-0.49676063284267863,7.544623460701567E-4,3.1223624302449435,0.03328159320969369,1.477795891948115,177]
["High","Q53HV7-1","single-strand selective monofunctional uracil DNA glycosylase [OS=Homo sapiens]",8,2,3,2,270,29.8,6.62,7.09,"DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","nucleic acid binding activity;other molecular function","SMUG1","ENSG00000123415; ENSPPAG00000033677","Fluoropyrimidine activity; Base excision repair; DNA repair pathways, full network","Displacement of DNA glycosylase by APEX1; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine","Base excision repair",118.7,100.6,113.4,114.9,121.9,127.4,0.913509060955519,-0.1305090560939721,0.18028898296809842,0.7440308111719282,0.4205845171840193,0.3761467188710698,3347]
["High","Q587I9","vesicle transport protein SFT2C [OS=Homo sapiens]",27,4,12,4,215,21.8,9.89,39.1,"transport","other membranes","","SFT2D3","ENSG00000173349","","","",346.4,340.3,351.9,328.7,363.7,335,1.0109013042631885,0.015642151740835445,0.7572850959947479,0.12074059037059803,0.8608068175173957,0.0650943020883964,6869]
["High","Q587J7-1","Putative ATP-dependent RNA helicase TDRD12 [OS=Homo sapiens]",15,15,33,15,1177,132.5,6.74,54.58,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","other cell component","nucleic acid binding activity;other molecular function","TDRD12","ENSG00000173809","","PIWI-interacting RNA (piRNA) biogenesis","",965.2,802.5,1079.5,1250.8,1449.6,1321.7,0.7078889137515229,-0.49840511332753695,0.01685371703724258,1.7733043018705597,0.1395480621705091,0.8552761899492526,943]
["High","Q5BJF2","sigma intracellular receptor 2 [OS=Homo sapiens]",10,2,10,2,176,20.8,9.38,9.4,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","","TMEM97","ENSG00000109084","","","",353.5,334.1,365,359.7,398.9,376.4,0.9274008810572686,-0.10873499757286606,0.13113184045087736,0.8822918433735333,0.3582496186985481,0.44581426316984923,2858]
["High","Q5EBL4-1","RILP-like protein 1 [OS=Homo sapiens]",42,12,26,12,403,47.1,5.21,59.7,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RILPL1","ENSG00000188026; ENSGGOG00000014925","","","",876.1,808.7,952.4,1123.2,1098.7,1099.6,0.7939786241156104,-0.33282792794422955,0.005709779713691789,2.2433806467407638,0.08018338130306743,1.0959156336641858,556]
["High","Q5EBM0-1","UMP-CMP kinase 2, mitochondrial [OS=Homo sapiens]",3,1,1,1,449,49.4,7.01,3.06,"other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","kinase activity;other molecular function","CMPK2","ENSG00000134326","Pyrimidine metabolism","","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",86.4,76,83.7,82.1,101.3,92.4,0.8923132704858595,-0.16437779905582026,0.19469655856295473,0.710641724958282,0.43620967841020103,0.3603047027336748,3485]
["High","Q5HYJ3-1","Protein FAM76B [OS=Homo sapiens]",17,6,9,4,339,38.7,9.25,11.8,"","nucleus","","FAM76B","ENSG00000077458","","","",234.2,191.8,230.9,202,208,199.1,1.0784764406501395,0.10899466112659827,0.3145725718881118,0.5022791469286738,0.5572102180813014,0.25398092811376705,4408]
["High","Q5JPI3","Uncharacterized protein C3orf38 [OS=Homo sapiens]",19,5,10,5,329,37.5,6.47,16.16,"other biological processes","nucleus","","C3orf38","ENSG00000179021","","","",341.1,295.6,344.1,344,333.1,348.9,0.9559454191033139,-0.06499984680363483,0.4094731522679702,0.38777456815047556,0.6354932166385036,0.19688908081758832,5031]
["High","Q5JRA6-1","Transport and Golgi organization protein 1 homolog [OS=Homo sapiens]",41,65,167,64,1907,213.6,4.84,369.78,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MIA3","ENSG00000154305","Type I collagen synthesis in the context of osteogenesis imperfecta","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER","",8000.7,7106.1,7475.2,6796.2,6426.3,6964.8,1.1186240854398557,0.1617252988820017,0.058659537516763394,1.2316613654043826,0.24169586750970373,0.6167307750498384,1895]
["High","Q5JTV8-3","Isoform 3 of Torsin-1A-interacting protein 1 [OS=Homo sapiens]",28,14,38,1,584,66.3,8.18,78.04,"","","","TOR1AIP1","","","","",24.3,16.4,20.9,21.6,18.4,15.8,1.1039426523297493,0.14266522886571406,0.5329659874714391,0.27330050565409897,0.717482487961551,0.14418869455840094,5800]
["High","Q5M775-1","Cytospin-B [OS=Homo sapiens]",16,16,23,16,1068,118.5,6.7,44.06,"cell organization and biogenesis","other membranes;cytosol;cytoskeleton;nucleus;other cell component","","SPECC1","ENSG00000128487","","","",1180.7,1174.1,1088.8,1202,962.1,1054.1,1.0700391523211734,0.09766358524904276,0.37817897712390297,0.4223026171431433,0.6088291656460689,0.21550455108677158,4850]
["High","Q5PRF9","protein Smaug homolog 2 [OS=Homo sapiens]",30,11,26,11,694,75.4,6.83,54.45,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMD4B","ENSG00000179134","","","",707.7,559.7,729,679.6,704,697,0.9595309045467655,-0.05959882143352074,0.6290200475649375,0.2013355128884627,0.7809490429936446,0.10737730295837503,6289]
["High","Q5RI15-1","Cytochrome c oxidase protein 20 homolog [OS=Homo sapiens]",22,2,3,2,118,13.3,8.76,10.54,"cell organization and biogenesis","other membranes;mitochondrion","","COX20; FAM36A","ENSG00000203667","Mitochondrial complex IV assembly","TP53 Regulates Metabolic Genes; Respiratory electron transport; Cytoprotection by HMOX1","Thermogenesis",272,263.2,260.8,293,330.5,322.9,0.8410819949281488,-0.24968164290877715,0.013714000802198102,1.8628358294666627,0.12582716599713606,0.9002255848926152,851]
["Medium","Q5SNT2-1","Transmembrane protein 201 [OS=Homo sapiens]",2,1,1,1,666,72.2,9.22,1.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TMEM201","ENSG00000188807; ENSPTRG00000049393","","","",48.5,39.9,73.8,54,45.2,43.4,1.1374474053295933,0.185799837773385,0.5740578173084716,0.24104436461683812,0.7465428776723095,0.1269452435294355,6004]
["High","Q5SRD1","Putative mitochondrial import inner membrane translocase subunit Tim23B [OS=Homo sapiens]",14,2,8,2,257,28,9.39,24.02,"","","","","","","","",268.9,293.8,293,342.2,461.5,403.5,0.7088303512259775,-0.49648771528093644,0.029657664503666005,1.5278630519963199,0.17771837639648824,0.7502676630502692,1303]
["High","Q5SYC1-1","Clavesin-2 [OS=Homo sapiens]",6,1,1,1,327,38,6.2,3.32,"cell organization and biogenesis","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLVS2; LOC101343624","ENSAMEG00000028872; ENSCAFG00000001006; ENSCATG00000031634; ENSCSAG00000016282; ENSDLEG00000011174; ENSECAG00000006114; ENSFCAG00000010835; ENSG00000146352; ENSGGOG00000027351; ENSLAFG00000007550; ENSMFAG00000003285; ENSMLEG00000033559; ENSMMUG00000018176; ENSMNEG00000035011; ENSNLEG00000013863; ENSOARG00000008112; ENSPANG00000003404; ENSPCOG00000011744; ENSPPAG00000036654; ENSPPYG00000016981; ENSPTRG00000018566; ENSRBIG00000041651; ENSRROG00000010239; ENSSSUG00005005271; ENSSTOG00000001439; ENSTTRG00000010743; ENSUAMG00000008720; ENSUMAG00000001385; ENSVVUG00000000265","","Lysosome Vesicle Biogenesis; Lysosome Vesicle Biogenesis","",26.8,22.2,24.1,25.6,18.6,23.6,1.0781710914454274,0.10858613281609307,0.5144237895390465,0.2886789556619113,0.7057847388369136,0.1513277366116009,5691]
["High","Q5T0D9","Tumor protein p63-regulated gene 1-like protein [OS=Homo sapiens]",21,2,5,2,272,30.2,7.34,18.33,"other biological processes","other membranes;ER/Golgi;other cell component","","TPRG1L","ENSG00000158109","","","",74.9,78.5,93.8,87.6,82.9,84,0.9713163064833006,-0.04198691305868309,0.7042245670477325,0.15228882853143588,0.8307275146560955,0.08054140496100415,6619]
["High","Q5T160","probable arginine--tRNA ligase, mitochondrial [OS=Homo sapiens]",22,11,12,11,578,65.5,8.21,25.19,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","RARS2","ENSG00000146282","","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",479.8,346.7,485.2,425.8,484.1,475.5,0.9468023675472788,-0.07886478124782202,0.6411461931574988,0.19304293203734876,0.7898500277964264,0.10245536223299505,6338]
["High","Q5T2E6-1","UPF0668 protein C10orf76 [OS=Homo sapiens]",5,3,5,3,689,78.7,6.6,10.73,"other biological processes","other membranes;cytosol;ER/Golgi","","ARMH3","ENSG00000120029; ENSNLEG00000014964; ENSPTRG00000002879","","","",139.4,107.6,165.2,159.5,165.2,152.7,0.8634268956849602,-0.21185406154252026,0.27131611897928076,0.5665244038948585,0.5177019200855876,0.28592022427634556,4092]
["Medium","Q5T4F4-1","Protrudin [OS=Homo sapiens]",4,1,1,1,411,45.8,5.15,0,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ZFYVE27","ENSG00000155256","","","Endocytosis",29,34.6,27.4,25.9,38.2,31.4,0.9528795811518325,-0.06963418783705241,0.7374641921555103,0.13225906216581362,0.8502835812684916,0.07043620694407582,6772]
["High","Q5T5U3-3","Isoform 3 of Rho GTPase-activating protein 21 [OS=Homo sapiens]",6,5,7,1,1164,129.2,8.44,11.46,"","","","","","","","",19.5,22.8,23,26.5,32.9,31,0.7223451327433628,-0.46923978086875706,0.019369372805041085,1.7128844418374065,0.14798049203694794,0.829795532977465,1022]
["Medium","Q5T7M9-1","Protein FAM69A [OS=Homo sapiens]",3,1,1,1,428,49,7.17,0,"","other membranes;ER/Golgi","","DIPK1A","ENSG00000154511; ENSPCOG00000022059; ENSPTRG00000000964","","","",63,36.7,75,43,74.9,58.3,0.9914869466515324,-0.012334316003654082,0.9742977635572923,0.011308294346254074,0.9856591005254389,0.006273263922996533,7718]
["High","Q5T8A7","Protein phosphatase 1 regulatory subunit 26 [OS=Homo sapiens]",1,1,1,1,1209,127.3,8.59,3.09,"other biological processes","nucleus","enzyme regulator activity","PPP1R26","ENSG00000196422","","","",25.8,21.2,19.8,33.8,19.1,25.4,0.8531289910600256,-0.22916420481698835,0.4540261743141709,0.34291910962627653,0.6632434740963605,0.1783270145124379,5345]
["High","Q5TAX3","Terminal uridylyltransferase 4 [OS=Homo sapiens]",16,23,37,23,1644,185,7.97,69.36,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TUT4","ENSG00000134744","","Deadenylation of mRNA","",1557.5,1491.1,1521.6,1841.1,1759.3,1778.5,0.8496532748331443,-0.2350538662595145,9.9607897283722187E-4,3.001706227733154,0.038693455820462824,1.4123624804950077,201]
["High","Q5TC63","Growth hormone-regulated TBC protein 1 [OS=Homo sapiens]",11,3,6,3,336,38.5,8.78,2.46,"transport;other biological processes","","enzyme regulator activity","GRTP1","ENSG00000139835","","","",286.6,201.8,271.6,225.8,305.6,286,0.9297773427942255,-0.10504282480234862,0.6183558306607855,0.20876153976466633,0.7738615684884458,0.11133672073639417,6239]
["High","Q5TFE4","5'-nucleotidase domain-containing protein 1 [OS=Homo sapiens]",40,11,29,11,455,51.8,6.35,39.56,"other metabolic processes","","other molecular function","NT5DC1","ENSG00000178425","","","",1440,1478.8,1321.9,1319.2,1239.4,1276.4,1.1057887874837027,0.14507584818633212,0.06164096106547618,1.2101305986658306,0.24732406166456217,0.6067336299395283,1946]
["High","Q5U4P2","Aspartate beta-hydroxylase domain-containing protein 1 [OS=Homo sapiens]",3,1,1,1,390,41.1,8.56,2.56,"protein metabolism;other metabolic processes","other membranes","other molecular function","ASPHD1","ENSG00000174939","16p11.2 proximal deletion syndrome","","",49.8,45,58.8,63.8,69.5,54.6,0.817456093666844,-0.2907868506988994,0.12624196471321714,0.898796255124286,0.353169924930419,0.45201628695428153,2791]
["High","Q5VST6-1","Protein ABHD17B [OS=Homo sapiens]",6,2,5,2,288,32.2,6.29,9.62,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","Abhd17b; ABHD17B; FAM108B1; LOC111153563; LOC112838645","ENSAMEG00000007245; ENSBIXG00000020353; ENSBIXG00005014706; ENSBMUG00000011067; ENSBTAG00000006816; ENSCATG00000030905; ENSCHIG00000013948; ENSCSAG00000008296; ENSDLEG00000009276; ENSECAG00000020790; ENSG00000107362; ENSLCNG00005018778; ENSMFAG00000001017; ENSMMUG00000018880; ENSNLEG00000001017; ENSPANG00000025076; ENSPCOG00000021794; ENSPPAG00000033499; ENSPPYG00000019288; ENSRFEG00010009213; ENSRROG00000042653; ENSSBOG00000018778; ENSSSCG00070028547; ENSSSUG00005013616; ENSUAMG00000021312","","RAS processing; RAS processing","",88.9,91.6,100.2,73.3,74,81.2,1.2284463894967177,0.29683489856709233,0.014813666293656318,1.8293374428932807,0.13040034545757442,0.8847212580663718,887]
["High","Q5VT66-1","Mitochondrial amidoxime-reducing component 1 [OS=Homo sapiens]",31,8,27,7,337,37.5,8.88,56.93,"other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;other cell component","other molecular function","MTARC1","ENSG00000186205","","Phase I - Functionalization of compounds","",619,586.7,607.4,657.9,606.4,648.5,0.9478774571309075,-0.0772275372585498,0.1458263913974808,0.836163871072367,0.3765252857247124,0.42420585324290044,3024]
["High","Q5VTR2","E3 ubiquitin-protein ligase BRE1A [OS=Homo sapiens]",51,45,129,43,975,113.6,5.94,291.67,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNF20","ENSG00000155827","ATM signaling in development and disease","E3 ubiquitin ligases ubiquitinate target proteins; RHOBTB1 GTPase cycle","",5145.6,4920.5,5224.7,4686.5,4731.9,4688.4,1.0839311537698133,0.11627312636972846,0.01290003387090394,1.889409149396304,0.12179379016205315,0.9143748542902154,827]
["High","Q5VV42","threonylcarbamoyladenosine tRNA methylthiotransferase [OS=Homo sapiens]",23,8,16,8,579,65.1,7.46,36.1,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;ER/Golgi","other molecular function","CDKAL1","ENSG00000145996","Vitamin D receptor pathway","tRNA modification in the nucleus and cytosol","",249.4,234.8,232.5,231.5,229,241,1.0216678545972915,0.03092625067022687,0.47488078474478024,0.3234154030609441,0.6772363775867113,0.1692597219144646,5475]
["High","Q5VWN6-1","Protein FAM208B [OS=Homo sapiens]",7,12,15,12,2430,268.7,5.9,32.35,"","cytosol;nucleus","","TASOR2","ENSG00000108021","","","",550.5,441.3,538.4,586.1,565.5,566.6,0.8905831684320802,-0.16717774904976765,0.1496492449374103,0.8249254700723261,0.380730304487227,0.4193825538455133,3069]
["Low","Q5VYS4-1","Mesenteric estrogen-dependent adipogenesis protein [OS=Homo sapiens]",3,1,1,1,303,34.2,6.3,0,"other biological processes","other cell component","","MEDAG","ENSG00000102802","","","",98.5,131.9,103.1,96,88.3,75,1.286155032780563,0.36306455521865283,0.11081794497358091,0.9553899077306099,0.33253901397145263,0.478157395297542,2602]
["High","Q5VZL5","Zinc finger MYM-type protein 4 [OS=Homo sapiens]",17,22,51,21,1548,172.7,6.84,94.29,"cell organization and biogenesis;developmental processes;other biological processes","","nucleic acid binding activity;other molecular function","ZMYM4","ENSG00000146463","","","",1974.2,1751.3,1934.6,2135,2278,2168.1,0.8600537903997811,-0.21750120168170595,0.019367105624730003,1.7129352788747223,0.14810809081086374,0.829421216302997,1021]
["High","Q5XUX0-1","F-box only protein 31 [OS=Homo sapiens]",3,1,1,1,539,60.6,7.02,3.8,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","FBXO31","ENSG00000103264","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",34.8,19.8,21.6,15.5,18.6,14.6,1.5646817248459954,0.6458692254109795,0.1336069591165505,0.8741709203993594,0.3617209212142948,0.4416263717881155,2884]
["High","Q63HQ0","AP-1 complex-associated regulatory protein [OS=Homo sapiens]",7,3,5,3,302,34.3,4.87,9.71,"transport;other biological processes","cytosol;ER/Golgi;other cytoplasmic organelle","cytoskeletal activity;other molecular function","AP1AR","ENSG00000138660","","","",241.5,257.8,254.7,214.3,203.2,210.9,1.1998726925525143,0.26288134286183024,2.1902658175351804E-3,2.659503174619621,0.051510829829261105,1.288101453665022,332]
["High","Q66K64","DDB1- and CUL4-associated factor 15 [OS=Homo sapiens]",12,5,8,5,600,66.4,6.58,21.51,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","DCAF15","ENSG00000132017; ENSG00000288453","","","",290.3,302.9,305.1,352.8,360.3,356.6,0.8397681592969992,-0.2519370069944643,3.5979011438065764E-4,3.4439507735333,0.02601149271374236,1.5848347243616143,108]
["High","Q676U5","Autophagy-related protein 16-1 [OS=Homo sapiens]",21,11,18,11,607,68.2,6.64,40.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","ATG16L1","ENSG00000085978; ENSG00000281089","Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy","Macroautophagy","Autophagy; Autophagy; NOD-like receptor signaling pathway; Shigellosis",669.4,619.3,643.9,732.3,638.1,672.9,0.9458229334899426,-0.08035797145590103,0.3007052728490263,0.5218589565048742,0.5445052807062146,0.2639979040249212,4312]
["High","Q68CP9-1","AT-rich interactive domain-containing protein 2 [OS=Homo sapiens]",10,15,23,15,1835,197.3,7.42,48.14,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;nucleus","nucleic acid binding activity;other molecular function","ARID2","ENSG00000189079","","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Hepatocellular carcinoma",785.2,771.3,908.7,982,1070.8,1038.3,0.7975154475752966,-0.32641563127702067,0.014760338437640737,1.8309036845241717,0.13022454522158067,0.8853071505633618,885]
["High","Q68D06","Schlafen family member 13 [OS=Homo sapiens]",3,2,2,2,897,102,6.96,6.51,"RNA metabolism OR transcription;other metabolic processes;stress response","other cell component","nucleic acid binding activity;other molecular function","SLFN13","ENSG00000154760","","","",55.8,47.9,52.3,57.1,69.3,71.1,0.7898734177215191,-0.34030662420221675,0.04924783769276864,1.3076128331605692,0.22395289266461127,0.6498433236628504,1717]
["High","Q68E01-2","Isoform 2 of Integrator complex subunit 3 [OS=Homo sapiens]",12,10,34,10,1042,117.9,5.8,83.06,"","","","INTS3","","","","",927.6,965.6,964.6,1028.4,1036.5,1046.6,0.9184637634581391,-0.12270529168955821,3.3740314125138E-3,2.4718508784102307,0.06169657440025234,1.2097389487766192,427]
["High","Q69YN2-1","CWF19-like protein 1 [OS=Homo sapiens]",18,6,14,6,538,60.6,7.24,36.93,"RNA metabolism OR transcription;other metabolic processes","nucleus","enzyme regulator activity","CWF19L1","ENSG00000095485","","","",311.9,239.7,302.6,340,320.1,336.9,0.8567703109327983,-0.22301960664341666,0.11282544203985241,0.9475929562780793,0.33508598381406146,0.47484373772580657,2629]
["High","Q6AI39","BRD4-interacting chromatin-remodeling complex-associated protein-like [OS=Homo sapiens]",2,2,2,2,1079,115,6.87,2.43,"other biological processes","nucleus","","BICRAL","ENSG00000112624","","","",56.7,58.5,66.6,86.5,76.6,92.2,0.7121034077555816,-0.48984133821301196,0.011073924087260925,1.955698457941359,0.1146753306012378,0.9405299991524976,754]
["High","Q6DD88","Atlastin-3 [OS=Homo sapiens]",24,9,18,9,541,60.5,5.66,40.43,"cell organization and biogenesis;other biological processes","other membranes;ER/Golgi","other molecular function","ATL3","ENSG00000184743","","","",887.9,734.9,881.3,844.8,854.4,883,0.9697544729300597,-0.044308569777355464,0.6381266720724278,0.1950931025931049,0.7883691543578347,0.10327037621685456,6320]
["High","Q6F5E8","capping protein, Arp2/3 and myosin-I linker protein 2 [OS=Homo sapiens]",9,9,10,9,1435,154.6,6.76,20.36,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","CARMIL2","ENSG00000159753","","","",266.8,226.6,262.1,312.6,247.3,256.1,0.9258578431372547,-0.11113739680666677,0.4493393125462715,0.34742558346566976,0.6596054431963316,0.1807157691276146,5319]
["High","Q6I9Y2","THO complex subunit 7 homolog [OS=Homo sapiens]",19,3,3,3,204,23.7,5.67,5.61,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","THOC7","ENSG00000163634","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Nucleocytoplasmic transport",127.9,156.2,159.8,190.5,182.9,168.2,0.8196085672082719,-0.28699303024990325,0.0536283721412352,1.270605385599091,0.23211215614122196,0.6343021141463787,1804]
["High","Q6IBS0","Twinfilin-2 [OS=Homo sapiens]",44,13,48,10,349,39.5,6.84,110.24,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","TWF2","ENSG00000247596","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",1725,1514.3,1864.5,1661.8,1841.9,1711.5,{"$f":"AVERAGE(T3906:V3906)/AVERAGE(W3906:Y3906)","v":0.9786393618653169},{"$f":"LOG(Z3906,2)","v":-0.031150784295175694},{"$f":"TTEST(T3906:V3906,W3906:Y3906,2,2)","v":0.7631155828556218},{"$f":"-LOG10(AB3906)","v":0.11740967804152369},{"$f":"AB3906*7808/AF3906","v":0.8647904892506089},{"$f":"-LOG10(AD3906)","v":0.06308909529051407},6890]
["Medium","Q6IQ26","DENN domain-containing protein 5A [OS=Homo sapiens]",2,1,1,1,1287,147,6.65,0,"transport;other biological processes","other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","DENND5A","ENSG00000184014","","RAB GEFs exchange GTP for GDP on RABs","",11.1,13.2,8.1,10.1,13.1,16.5,0.8161209068010075,-0.29314519425833324,0.36223216988634505,0.4410129825594742,0.5969414906020646,0.22406823428758507,4738]
["Medium","Q6IQ55","tau-tubulin kinase 2 [OS=Homo sapiens]",1,1,1,1,1244,137.3,7.01,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","TTBK2","ENSG00000128881","Genes related to primary cilium development (based on CRISPR); Ciliopathies","Anchoring of the basal body to the plasma membrane","",73.5,61.1,79.7,75.8,74,76.2,0.9482300884955753,-0.07669092262600233,0.5180995089617336,0.285586819323206,0.7085866116610994,0.1496070576712535,5709]
["High","Q6N075","Molybdate-anion transporter [OS=Homo sapiens]",3,1,4,1,450,49.7,7.8,0,"transport","plasma membrane;other membranes","transporter activity","MFSD5","ENSG00000182544","","","",86.6,100.4,87.6,89.5,104.6,101,0.9305320230430363,-0.10387229528490648,0.34324492414990126,0.4643958763198687,0.5833818824036633,0.23404706252024055,4594]
["Medium","Q6NT16","MFS-type transporter SLC18B1 [OS=Homo sapiens]",2,1,1,1,456,48.8,5.22,0,"transport","other membranes","transporter activity","SLC18B1","ENSG00000146409","","","",15.1,10.7,18.2,15.7,16.9,11.6,0.995475113122172,-0.006542845866771941,0.9815077689433016,0.008106258472683193,0.9898750529461765,4.419620796984102E-3,7742]
["High","Q6NUQ4","Transmembrane protein 214 [OS=Homo sapiens]",15,8,20,8,689,77.1,9.14,37.79,"other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi","","TMEM214","ENSG00000119777","","","",855.9,915.5,908.9,829.5,840.5,895.7,1.0446661729742373,0.06304199729502823,0.24199864693587733,0.6161870622423989,0.4897681273393806,0.3100094808916292,3858]
["High","Q6NW29","RWD domain-containing protein 4 [OS=Homo sapiens]",11,2,5,2,188,21.2,5.31,10.8,"","","","RWDD4","ENSG00000182552","","","",186.6,148.7,193.5,199.4,176.3,182,0.948180025103102,-0.07676709413294619,0.569442983405267,0.24454975399418652,0.7423961954296752,0.12936426241975993,5989]
["High","Q6NYC1","Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 [OS=Homo sapiens]",15,5,11,5,403,46.4,8.69,32.12,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","JMJD6","ENSG00000070495","","HDMs demethylate histones","",313.4,299.2,337,348.1,391.9,359,0.8640582347588717,-0.21079954619468683,0.04410644191315262,1.355497975543075,0.20935142763397913,0.6791240731704328,1645]
["High","Q6P1A2","Lysophospholipid acyltransferase 5 [OS=Homo sapiens]",10,4,10,4,487,56,8.69,17.01,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","LPCAT3","ENSG00000111684","Ferroptosis","Acyl chain remodelling of PC; Acyl chain remodelling of PS; Acyl chain remodelling of PE","Glycerophospholipid metabolism; Ferroptosis",316.6,188.9,335,275.9,366.4,339.2,0.8563423331635253,-0.2237404482300036,0.42682213994701557,0.36975306111393413,0.6476150930249315,0.18868303832962655,5146]
["High","Q6P1M0","Long-chain fatty acid transport protein 4 [OS=Homo sapiens]",16,7,9,7,643,72,8.47,24.82,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","SLC27A4","ENSG00000167114","PPAR signaling pathway; Fatty acid transporters","Transport of fatty acids; Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)","PPAR signaling pathway; Insulin resistance; Fat digestion and absorption",217.2,232.1,205.3,206,227.2,233.2,0.9822929171668666,-0.025774798320784414,0.7457831588418575,0.12738742803375097,0.8540737612550929,0.06850462026798793,6818]
["High","Q6P1R4","tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like [OS=Homo sapiens]",16,5,5,5,473,53.2,8.29,5.5,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","DUS1L","ENSG00000169718","","","",133.6,353.9,114.2,125.4,131.7,127.4,1.5648894668400524,0.6460607585806654,0.3997277351683745,0.39823571710719563,0.6270994888878176,0.20266355319258333,4977]
["High","Q6P4A8","Phospholipase B-like 1 [OS=Homo sapiens]",10,4,14,4,553,63.2,9.06,29.02,"other metabolic processes","non-structural extracellular;cytosol;other cytoplasmic organelle","other molecular function","PLBD1","ENSG00000121316","","Acyl chain remodelling of PC; Acyl chain remodelling of PE; Acyl chain remodelling of PI; Hydrolysis of LPC","",530,541.9,519.1,519.8,510.4,542.8,1.0114431023521935,0.01641516491536136,0.6339855227444244,0.19792065925390817,0.7846186339496697,0.10534138200125628,6309]
["High","Q6P4E1","Protein CASC4 [OS=Homo sapiens]",15,6,10,6,433,48.8,5.82,17.92,"","","","","","","","",263.3,208.2,291.1,258.9,269,275.2,0.9495704146432575,-0.07465310863581863,0.6153783821361201,0.21085776431848904,0.7721154439528886,0.11231776064432417,6223]
["High","Q6P9B6","TLD domain-containing protein 1 [OS=Homo sapiens]",12,4,7,4,456,51,6.24,17.31,"signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","","MEAK7","ENSG00000140950","","","",362.2,247.1,343.8,376.7,339.3,361.9,0.8842193153353742,-0.17752384528867168,0.32740520659930117,0.48491441845075295,0.5678320420096277,0.24578010445661871,4502]
["High","Q6PCT2-1","F-box/LRR-repeat protein 19 [OS=Homo sapiens]",2,2,3,2,694,75.7,9.17,1.75,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","FBXL19","ENSG00000099364; ENSGGOG00000003625; ENSPTRG00000008021","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",189.5,177.9,170.3,226.8,197.7,210.3,0.8470384373030877,-0.23950065655971395,0.03282707570707011,1.4837678032544654,0.18533174773738495,0.7320501787051407,1383]
["High","Q6PD74","Alpha- and gamma-adaptin-binding protein p34 [OS=Homo sapiens]",18,4,21,4,315,34.6,4.64,69.18,"transport","cytosol;nucleus;other cell component","","AAGAB","ENSG00000103591","","","",810.4,786.3,851.6,748.7,774.5,705.7,1.0984342052133338,0.13544845678419376,0.05744909574867944,1.240716802736347,0.2398730158319193,0.6200186046142107,1870]
["High","Q6PIW4","Fidgetin-like protein 1 [OS=Homo sapiens]",16,7,9,6,674,74,7.85,16.75,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","FIGNL1","ENSG00000132436","","","",154.9,161.6,152.5,155.2,195.5,167.6,0.9048813428516305,-0.1441994709819602,0.2500176728900506,0.6020292914585473,0.49710669465890384,0.3035503880703302,3927]
["High","Q6PJW8","Consortin [OS=Homo sapiens]",8,4,6,4,725,79.5,4.53,11.79,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","CNST","ENSG00000162852","","","",283,297.6,289.6,288.7,252.8,273.5,1.0677300613496932,0.09454695753472708,0.1765936490869036,0.7530249191962123,0.4155645605999226,0.38136149622591886,3318]
["High","Q6PL24","Protein TMED8 [OS=Homo sapiens]",13,3,5,3,325,35.7,4.74,10.14,"","","","TMED8","ENSG00000100580","","","",80.5,104,88.9,80.1,76.8,73.4,1.187147199305254,0.24749883181321447,0.11459483375959799,0.9408349610795653,0.33662771331638114,0.4728501330276431,2658]
["High","Q6RFH5-1","WD repeat-containing protein 74 [OS=Homo sapiens]",48,12,22,12,385,42.4,8.32,50.14,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","","WDR74","ENSG00000133316","","","",702.1,771.4,696.7,802.2,763.2,791.4,{"$f":"AVERAGE(T4034:V4034)/AVERAGE(W4034:Y4034)","v":0.9208248472505091},{"$f":"LOG(Z4034,2)","v":-0.11900133165891902},{"$f":"TTEST(T4034:V4034,W4034:Y4034,2,2)","v":0.08038891803864719},{"$f":"-LOG10(AB4034)","v":1.0948038165050813},{"$f":"AB4034*7808/AF4034","v":0.28260993788642824},{"$f":"-LOG10(AD4034)","v":0.54881257039492},2221]
["High","Q6UB35-1","Monofunctional C1-tetrahydrofolate synthase, mitochondrial [OS=Homo sapiens]",22,20,54,19,978,105.7,8.06,110.51,"other metabolic processes;developmental processes","cytosol;mitochondrion","other molecular function","MTHFD1L","ENSG00000120254","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism","Metabolism of folate and pterines","One carbon pool by folate; Metabolic pathways; Biosynthesis of cofactors",1908,1895.1,1906.3,2031.4,2071.1,2039.1,0.9296274586426989,-0.10527541226519324,3.5616762081593843E-4,3.4483455647721004,0.025990250311503243,1.5851895377986747,107]
["High","Q6ULP2","Aftiphilin [OS=Homo sapiens]",9,6,9,6,937,102.1,4.54,14.03,"","","","","","","","",237.8,244.1,238.7,237.4,221,212.9,1.0734395948160285,0.10224100935105516,0.09266910724072976,1.0330650208819014,0.303634238076214,0.5176492585697221,2383]
["High","Q6UW68","Transmembrane protein 205 [OS=Homo sapiens]",9,1,5,1,189,21.2,8.62,8.89,"","other membranes","","TMEM205","ENSG00000105518","","","",66,74.5,80,72,72.3,61.3,1.0724708171206223,0.10093839125100447,0.4134565158308699,0.38357015945545986,0.6382499951774283,0.19500917980521038,5058]
["High","Q6UWZ7","BRCA1-A complex subunit Abraxas 1 [OS=Homo sapiens]",9,4,5,4,409,46.6,7.05,6.94,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","cytoskeletal activity;other molecular function","ABRAXAS1","ENSG00000163322","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Homologous recombination",354.4,344,310.8,396.3,349.7,374.8,0.9004282655246254,-0.15131674945451745,0.11925596506498876,0.9235198887656829,0.34385176337792916,0.46362874412015426,2708]
["Medium","Q6UX68","XK-related protein 5 [OS=Homo sapiens]",1,1,1,1,686,74.9,6.68,0,"","","","","","","","",12.4,12.2,20.2,16.8,22.1,20,0.760611205432937,-0.3947689017728569,0.19836043784892418,0.7025449417442983,0.4397496589223169,0.356794488716921,3522]
["High","Q6V1X1","Dipeptidyl peptidase 8 [OS=Homo sapiens]",6,5,5,4,898,103.3,5.8,13.75,"protein metabolism;other biological processes","cytosol;other cell component","other molecular function","DPP8","ENSG00000074603","","","",280.4,214.4,254.9,264.1,260.7,255.7,0.9605381165919281,-0.05808523005741141,0.6241501811394027,0.20471089911142654,0.7782441096033944,0.10888415773368762,6262]
["High","Q6VEQ5","WAS protein family homolog 2 [OS=Homo sapiens]",11,4,8,4,465,50.3,5.71,11.75,"cell organization and biogenesis;transport","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity","WASH2P","","","","",281.9,297.6,275.1,332.4,297.9,287.6,0.9310382394596363,-0.10308767173718736,0.23474886824164576,0.6293964928535146,0.4805766028397404,0.3182373769048661,3814]
["High","Q6XZF7","Dynamin-binding protein [OS=Homo sapiens]",5,5,5,5,1577,177.2,5.39,9.6,"signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity","DNMBP","ENSG00000107554","","CDC42 GTPase cycle","",77.4,52.1,77.1,58.5,57.1,62.4,1.1606741573033705,0.2149630130112991,0.3264406746629613,0.4861957332481043,0.5667887008602183,0.2465788161574108,4497]
["High","Q6Y7W6-1","GRB10-interacting GYF protein 2 [OS=Homo sapiens]",34,41,102,40,1299,150,5.54,190.35,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GIGYF2","ENSG00000204120","VEGFA-VEGFR2 signaling pathway","","",4361.8,4119.6,3993.5,4138.3,3581,3682.8,1.0940879311705738,0.12972869129851866,0.15227165211645932,0.8173809402312779,0.3835280837823595,0.4162028294069153,3100]
["High","Q6ZN17-1","Protein lin-28 homolog B [OS=Homo sapiens]",44,9,24,7,250,27.1,8.91,34.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","LIN28B","ENSG00000187772","Cardiac progenitor differentiation; Hippo-Merlin signaling dysregulation; Malignant pleural mesothelioma; CCL18 signaling pathway","","",535.9,625.1,559.5,650.3,559.4,555.2,0.9748427672955976,-0.03675855001011763,0.7358921138218373,0.13318585116011966,0.8497257652648484,0.07072121293123444,6762]
["High","Q6ZPD9-1","probable C-mannosyltransferase DPY19L3 [OS=Homo sapiens]",7,3,4,3,716,83.1,8.72,8.3,"protein metabolism;other metabolic processes","other membranes;nucleus","other molecular function","DPY19L3","ENSG00000178904; ENSPPAG00000028384","","","",22.2,26.7,23.6,23.2,21.1,17.7,1.1693548387096775,0.22571277962805936,0.16807442405729628,0.7744983682729513,0.4050386120491881,0.39250357382092793,3240]
["High","Q6ZRS2","Helicase SRCAP [OS=Homo sapiens]",5,14,28,13,3230,343.3,5.96,54.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","SRCAP","ENSG00000080603","Pathways affected in adenoid cystic carcinoma","","",731.9,672.4,667.3,768.7,716.3,751.4,0.9263101412985154,-0.11043278649841379,0.10064861373745489,0.9971922023979781,0.31573498435598546,0.500677294347936,2489]
["High","Q6ZTU2","EP400 N-terminal-like protein [OS=Homo sapiens]",5,1,1,1,488,51.7,7.27,0,"","","","EP400P1","","","","",20.1,28.3,19.3,19.4,15,14.8,1.3760162601626014,0.46049751823575663,0.1301092327611635,0.885691884107484,0.35670396397442583,0.44769206441366727,2848]
["High","Q6ZV29-1","Patatin-like phospholipase domain-containing protein 7 [OS=Homo sapiens]",1,2,4,1,1317,145.6,7.74,0,"","","","","","","","",25.2,25.5,24.5,24.9,30,22.4,0.9728331177231565,-0.039735752247210064,0.7718259304749842,0.11248063484336658,0.8704921082115666,0.060235161796167454,6923]
["High","Q6ZW49","PAX-interacting protein 1 [OS=Homo sapiens]",4,4,7,4,1069,121.3,6.7,24.58,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","","PAXIP1","ENSG00000157212","16p11.2 proximal deletion syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nonhomologous End-Joining (NHEJ)","",97.9,122.5,100.5,114,113.2,113.7,0.9413317688471692,-0.08722480985813891,0.4412288027482201,0.35533614522022744,0.6538459844103439,0.18452453913438036,5269]
["Medium","Q70CQ4-1","Ubiquitin carboxyl-terminal hydrolase 31 [OS=Homo sapiens]",1,2,2,2,1352,146.6,9.22,2.03,"protein metabolism;other metabolic processes","nucleus","other molecular function","USP31","ENSG00000103404","","","",70.3,70.6,62.9,52.4,57.8,54.6,1.2366504854368932,0.3064378089825954,0.011851052177905188,1.926243089757458,0.11727885349186781,0.930780288308243,789]
["High","Q70UQ0","Inhibitor of nuclear factor kappa-B kinase-interacting protein [OS=Homo sapiens]",20,8,17,5,350,39.3,9.17,28.46,"other biological processes","other membranes;ER/Golgi","","IKBIP","ENSG00000166130","","","",726.4,639.3,734.4,754.5,775.8,817.2,0.8946112886048988,-0.1606671318594568,0.08136394502317129,1.089568002314197,0.2850110734593636,0.5451382661357992,2229]
["High","Q712K3","Ubiquitin-conjugating enzyme E2 R2 [OS=Homo sapiens]",8,3,8,3,238,27.1,4.42,16.66,"protein metabolism;other metabolic processes","cytosol","other molecular function","UBE2R2","ENSG00000107341","","Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes","Ubiquitin mediated proteolysis",404.6,309.3,452.5,560,518.8,506.6,0.7357133846347924,-0.44278425672990107,0.036285830239729935,1.4402629355724257,0.19247266474987185,0.7156309409152704,1472]
["High","Q71UM5","40S ribosomal protein S27-like [OS=Homo sapiens]",39,3,17,1,84,9.5,9.45,25.77,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;translational apparatus;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPS27L","ENSG00000185088","","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",177.9,678.8,182.8,213.7,186.1,213.2,1.695758564437194,0.7619307791675883,0.4410664541587813,0.35549597175625797,0.6537294749566751,0.18460193338736874,5268]
["High","Q76NI1-1","Protein very KIND [OS=Homo sapiens]",3,4,4,4,1749,191.3,6.16,8.25,"developmental processes;signal transduction;other biological processes","other cell component","enzyme regulator activity","KNDC1","ENSG00000171798","","","",177.4,152.2,187.7,203.9,192.9,184.7,0.8895958727429061,-0.16877800015682598,0.14708248037207333,0.8324390548786341,0.378516811715606,0.42191482667071034,3034]
["High","Q7KZF4","staphylococcal nuclease domain-containing protein 1 [OS=Homo sapiens]",55,49,244,49,910,101.9,7.17,624.26,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SND1","ENSG00000197157","VEGFA-VEGFR2 signaling pathway","Signaling by BRAF and RAF1 fusions","Viral carcinogenesis",9548.8,9880.5,9449,8292.7,8623.4,8547.3,1.1341101345460545,0.18156074861185648,0.002280659625599311,2.6419395256634073,0.052529175093449613,1.279599419207854,339]
["High","Q7L190","Developmental pluripotency-associated protein 4 [OS=Homo sapiens]",54,15,66,15,304,33.5,9.52,153.1,"developmental processes","nucleus","other molecular function","DPPA4","ENSG00000121570","","POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","",3084.1,3208.3,3254.6,4729.3,4706.9,4642.2,0.6781310376179112,-0.5603640176094922,1.2230780842742615E-5,4.912545815664521,0.007958161401677861,2.0991872570535106,12]
["Low","Q7L211","Protein Abhd13 [OS=Homo sapiens]",2,1,1,1,337,38.5,8.57,1.73,"protein metabolism;other metabolic processes","other membranes;other cell component","other molecular function","ABHD13","ENSG00000139826","","","",46.4,45.6,36.6,49.1,46.5,37.5,0.966190833959429,-0.04961992858394453,0.7662551927932252,0.11562656931685414,0.8674670937116866,0.06174699064716019,6897]
["High","Q7L3B6","Hsp90 co-chaperone Cdc37-like 1 [OS=Homo sapiens]",15,5,10,5,337,38.8,5.34,21.18,"other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","CDC37L1","ENSG00000106993","","Platelet degranulation","",536,360.7,582.7,481.2,445.6,451.5,1.073351229775811,0.10212224248851656,0.6483638006589185,0.18818124060474267,0.7947291295988753,0.09978086828145771,6370]
["High","Q7L5N7","Lysophosphatidylcholine acyltransferase 2 [OS=Homo sapiens]",6,3,4,3,544,60.2,6.55,8.36,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","LPCAT2","ENSG00000087253","","Acyl chain remodelling of PC","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways",126.4,119.3,125.8,107.3,120,121.2,1.0659971305595408,0.09220355467017304,0.19955139625064838,0.6999452291336261,0.4412623341617283,0.3553031420380878,3531]
["High","Q7L7L0","Histone H2A type 3 [OS=Homo sapiens]",35,6,156,1,130,14.1,11.05,351.11,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","H2AW","ENSG00000181218; ENSG00000284841","","HATs acetylate histones; HCMV Early Events; HCMV Late Events; Ub-specific processing proteases; UCH proteinases; RMTs methylate histone arginines; HDACs deacetylate histones; Metalloprotease DUBs","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus",49.1,678.1,3.2,31.1,21.5,32,8.63356973995272,3.1099571968642725,0.37881760602964265,0.4215698448117531,0.6096059084664983,0.21495083234765305,4852]
["High","Q7LGA3-1","Heparan sulfate 2-O-sulfotransferase 1 [OS=Homo sapiens]",18,5,8,5,356,41.9,8.69,17.7,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","HS2ST1","ENSG00000153936; ENSGGOG00000040966; ENSPPAG00000039539; ENSPTRG00000000927","Metapathway biotransformation Phase I and II","HS-GAG biosynthesis","Glycosaminoglycan biosynthesis",414.4,389.8,430.2,410.1,395.9,382,1.0390572390572392,0.05527513088260703,0.33974038547551155,0.46885282479124124,0.580204052885563,0.23641924185585,4572]
["High","Q7RTS7","Keratin, type II cytoskeletal 74 [OS=Homo sapiens]",5,3,14,1,529,57.8,7.71,19.02,"cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","KRT74","ENSG00000170484","","Formation of the cornified envelope","",123.9,126.7,137.9,136.9,105,139.4,1.018882769472856,0.02698806756895723,0.8496453839255105,0.0707622977433017,0.916682486899321,0.03778106571071983,7237]
["High","Q7Z2W9","39S ribosomal protein L21, mitochondrial [OS=Homo sapiens]",42,6,14,6,205,22.8,9.89,31.77,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL21","ENSG00000197345","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",337.6,313.8,358.9,361.5,394.8,381.2,0.8881758241758242,-0.17108279268426352,0.059175701100403204,1.2278565879450116,0.24279762175089237,0.6147555715733968,1903]
["Low","Q7Z3D4","LysM and putative peptidoglycan-binding domain-containing protein 3 [OS=Homo sapiens]",4,1,1,1,306,34.5,5.97,0,"cell organization and biogenesis","plasma membrane;other membranes;ER/Golgi","","LYSMD3","ENSG00000176018","","","",33.9,34.7,26.6,31.8,29.4,37.3,0.9664974619289338,-0.04916215103579538,0.7677257719387799,0.11479388023080422,0.8683764779513246,0.06129194896047465,6903]
["High","Q7Z3E2","Coiled-coil domain-containing protein 186 [OS=Homo sapiens]",7,5,7,5,898,103.6,6.27,13.45,"cell-cell signaling;transport;other biological processes","ER/Golgi","other molecular function","CCDC186","ENSG00000165813","","","",234.5,208.7,236.1,234.4,210.7,221.2,1.019510730901996,0.027876960580226384,0.7189514672117956,0.14330042565816212,0.8394755579467176,0.07599194419942686,6687]
["High","Q7Z408","CUB and sushi domain-containing protein 2 [OS=Homo sapiens]",0,1,1,1,3487,379.8,6.09,2.32,"","plasma membrane;other membranes","","CSMD2","ENSG00000121904","","","",22.9,20.6,35.5,34.9,34.1,31,0.7899999999999999,-0.34007544159762193,0.21704274453108233,0.6634547275068347,0.45950915111135865,0.337705835229791,3688]
["High","Q7Z4H8","KDEL motif-containing protein 2 [OS=Homo sapiens]",19,9,16,9,507,58.5,8.24,29.07,"protein metabolism;other metabolic processes","ER/Golgi;other cell component","other molecular function","POGLUT3","ENSG00000178202","","","",913.9,832.4,894.2,960.6,989.2,964.4,0.9060805709971861,-0.1422887507860776,0.025111049310378084,1.60013513913154,0.1646239068139648,0.7835070959556821,1191]
["High","Q7Z4L5","Tetratricopeptide repeat protein 21B [OS=Homo sapiens]",7,7,7,7,1316,150.8,6.96,16,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","TTC21B","ENSG00000123607","Nephrotic syndrome; Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",228.5,330.5,220.1,201.8,243.8,232.9,1.148268238761975,0.19945969909334707,0.4234205285093347,0.37322809009978786,0.6457163059767355,0.18995824641698322,5120]
["High","Q7Z4W1","L-xylulose reductase [OS=Homo sapiens]",58,10,24,10,244,25.9,8.1,64.3,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","DCXR","ENSG00000169738","","Formation of xylulose-5-phosphate; Essential pentosuria","Pentose and glucuronate interconversions; Metabolic pathways",720.5,520.5,738.6,408.9,468.6,442.5,1.4996969696969698,0.5846710177338249,0.03786503834941635,1.4217615989890722,0.19489137734491946,0.7102073751171672,1517]
["High","Q7Z624","Calmodulin-lysine N-methyltransferase [OS=Homo sapiens]",7,2,4,2,323,36.1,6.83,7.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","CAMKMT","ENSG00000143919","","Inactivation, recovery and regulation of the phototransduction cascade; Protein methylation","Lysine degradation; Metabolic pathways",157.3,151.1,179,158.1,195.6,156.2,0.9558737007256325,-0.06510808690521863,0.6510292217868274,0.18639951745953726,0.7962462662455433,0.0989525911435749,6384]
["High","Q7Z628","Neuroepithelial cell-transforming gene 1 protein [OS=Homo sapiens]",10,4,5,4,596,67.7,9.23,11.26,"stress response;signal transduction;other biological processes","cytosol;nucleus","enzyme regulator activity","NET1","ENSG00000173848","Apoptosis-related network due to altered Notch3 in ovarian cancer","RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events","",183.4,128,182.6,154.6,186.4,149.8,1.006519967400163,0.009375792809135041,0.9630404581035739,0.01635546743201277,0.9802398509806681,0.008667645519375234,7671]
["High","Q7Z6M1-1","Rab9 effector protein with Kelch motifs [OS=Homo sapiens]",20,6,9,6,372,40.5,6.25,17.75,"transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","RABEPK","ENSG00000136933","","Retrograde transport at the Trans-Golgi-Network","",530.8,504,494.4,502.2,527.2,513,0.9914419087136929,-0.012399851395313017,0.7534477533065627,0.12294685779839624,0.8581940273986348,0.06641451226529228,6855]
["High","Q7Z739","YTH domain-containing family protein 3 [OS=Homo sapiens]",19,10,30,6,585,63.8,9.04,50.5,"cell organization and biogenesis;other biological processes","cytosol;other cell component","translation activity;nucleic acid binding activity","YTHDF3","ENSG00000185728","","","",801.9,865.6,770,777.5,728.7,763.9,1.0737412448790804,0.10264636789828745,0.15258042814633355,0.8165011707925335,0.3836869510359331,0.4160229706464972,3105]
["High","Q7Z7H5","Transmembrane emp24 domain-containing protein 4 [OS=Homo sapiens]",34,7,49,5,227,25.9,8.28,112.09,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED4","ENSG00000158604","","","",740.4,552.9,752.3,756.4,803,753.8,0.8843160989106001,-0.1773659415418396,0.2510419956183414,0.6002536213886361,0.49838187179964644,0.30243776313974746,3933]
["High","Q86SQ9","Dehydrodolichyl diphosphate synthase complex subunit DHDDS [OS=Homo sapiens]",17,4,7,4,333,38.6,8.28,10.61,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DHDDS","ENSG00000117682","","Synthesis of Dolichyl-phosphate; Defective DHDDS causes retinitis pigmentosa 59","Terpenoid backbone biosynthesis",99.8,88.8,92.5,95.7,85.9,95.8,1.0133381398702233,0.019115666056739936,0.8021610530948269,0.09573842791485053,0.8892905725634542,0.05095631164854641,7043]
["High","Q86TB9","Protein PAT1 homolog 1 [OS=Homo sapiens]",18,8,9,8,770,86.8,6.67,25.84,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","PATL1","ENSG00000166889","","mRNA decay by 5' to 3' exoribonuclease","RNA degradation",323.8,261,332.1,320.7,284.6,300.5,1.0122543607860455,0.017571858149812148,0.8884272241975649,0.05137814177414554,0.9380445931757385,0.027776515448421437,7395]
["High","Q86TM6","E3 ubiquitin-protein ligase synoviolin [OS=Homo sapiens]",8,4,9,4,617,67.6,6.95,9.07,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","SYVN1","ENSG00000162298","","Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; XBP1(S) activates chaperone genes; ER Quality Control Compartment (ERQC)","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",304.7,282.1,286.9,265.5,247.9,268.9,1.1168349737952192,0.15941602550233233,0.03232749181779724,1.490427989540821,0.1835731317188079,0.736190883048467,1375]
["High","Q86U42-1","polyadenylate-binding protein 2 [OS=Homo sapiens]",69,14,44,14,306,32.7,5.06,93.31,"RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BCL2L2; BCL2L2-PABPN1; LOC101332651; LOC102975296; LOC106988220; LOC109255027; LOC110585402; LOC111164107; LOC112822568; LOC116541350; PABPN1","ENSCATG00000038536; ENSCCAG00000033954; ENSCJAG00000007960; ENSDLEG00000019901; ENSFCAG00000031922; ENSG00000100836; ENSGGOG00000022683; ENSMMUG00000014747; ENSMNEG00000045065; ENSOGAG00000008710; ENSPANG00000021100; ENSPTRG00000006167; ENSSSCG00000002023","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA surveillance pathway; Influenza A",1935.4,1877.4,1880.7,2419.8,2286.8,2371.9,0.8043370770643498,-0.3141278702280774,4.3434881699491891E-4,3.3621613570064763,0.0269158378023518,1.5699920974654036,126]
["High","Q86U90","YrdC domain-containing protein, mitochondrial [OS=Homo sapiens]",11,2,4,2,279,29.3,8.57,12.78,"other biological processes","other membranes;mitochondrion;other cell component","nucleic acid binding activity;other molecular function","YRDC","ENSG00000196449","","","",281.1,291.8,291.3,300.9,293.6,284.5,0.9831626848691695,-0.02449793444103278,0.4491878254064254,0.34757202318186514,0.6595070591901786,0.18078055151877795,5318]
["High","Q86UK7-1","E3 ubiquitin-protein ligase ZNF598 [OS=Homo sapiens]",16,12,23,12,904,98.6,8.4,54.84,"protein metabolism;other metabolic processes","","translation activity;other molecular function","ZNF598","","","","",726.2,684.6,743.2,710.9,632.1,664,1.0732436472346787,0.10197763318159053,0.16354232696945614,0.7863698271611131,0.399667758678408,0.3983008849968967,3195]
["High","Q86UV5","Ubiquitin carboxyl-terminal hydrolase 48 [OS=Homo sapiens]",22,15,29,15,1035,119,6.05,61.63,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","USP48","ENSG00000090686","","Ub-specific processing proteases","",1241.3,1148.7,1288.1,1417,1478,1527.5,0.83167891464104,-0.26590143871159416,0.00879891401126131,2.055570926488579,0.10223500089275045,0.990400394883769,672]
["High","Q86V21-1","acetoacetyl-CoA synthetase [OS=Homo sapiens]",19,14,38,14,672,75.1,6.24,75.73,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol","other molecular function","AACS","ENSG00000081760","","Synthesis of Ketone Bodies","Valine, leucine and isoleucine degradation; Butanoate metabolism; Metabolic pathways",1571.3,1260,1622,1380.7,1572.8,1473.1,1.0060317173451407,0.008675789969702011,0.9470912210719401,0.02360818900070994,0.97122251827288,0.012681256820422962,7614]
["Medium","Q86VI4-1","Lysosomal-associated transmembrane protein 4B [OS=Homo sapiens]",2,1,5,1,370,41.1,8.97,1.63,"","","","","","","","",56,62.4,70,76,61.6,70.6,0.9048991354466861,-0.14417110368663355,0.3210201722040565,0.4934676766242465,0.5631376105525214,0.24938546624813368,4451]
["High","Q86VP3-1","Phosphofurin acidic cluster sorting protein 2 [OS=Homo sapiens]",3,2,3,2,889,97.6,6.6,3.91,"cell organization and biogenesis;other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","PACS2","ENSG00000179364","","","",175.9,142.2,179.4,153.2,171.2,157.5,1.0323718613820296,0.04596272457838457,0.7104854693272475,0.14844479972880648,0.8343315603108962,0.07866132802156175,6649]
["High","Q86W42","THO complex subunit 6 homolog [OS=Homo sapiens]",34,8,18,8,341,37.5,7.43,38.82,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity","THOC6","ENSG00000131652","","mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","Nucleocytoplasmic transport",544.4,570.3,556.2,550.4,573.4,574,0.9841559665449404,-0.023041126548142388,0.45264526032152985,0.3442420227959329,0.6624656405980328,0.1788366418977862,5335]
["High","Q86WA8","Lon protease homolog 2, peroxisomal [OS=Homo sapiens]",4,3,5,3,852,94.6,7.3,4.92,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","LONP2","ENSG00000102910","IL-18 signaling pathway","Peroxisomal protein import; Association of TriC/CCT with target proteins during biosynthesis","",234.2,195.6,227.3,193.3,181.2,184.4,1.1757022723206298,0.2335227671234409,0.05789901836159222,1.237328799377187,0.24072179732018747,0.6184845826486437,1878]
["High","Q86WP2-1","Vasculin [OS=Homo sapiens]",2,1,1,1,473,53.3,7.05,2.89,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","GPBP1","ENSG00000062194; ENSGGOG00000008390","","","",66.7,52.6,75.1,110.9,60.9,85.7,0.7549514563106796,-0.40554421335216223,0.25534540694498425,0.5928719496603644,0.50245386527884,0.29890380848387005,3968]
["High","Q86X10-1","Ral GTPase-activating protein subunit beta [OS=Homo sapiens]",12,12,19,12,1494,166.7,6.79,32.52,"other biological processes","","enzyme regulator activity;other molecular function","RALGAPB","ENSG00000170471","","Translocation of SLC2A4 (GLUT4) to the plasma membrane","",361,326.5,375.7,370.4,327.4,349.8,1.0148911798396336,0.021325044925578504,0.7994298152098288,0.09721965850318447,0.8882806314441929,0.05144980738176785,7027]
["High","Q86X76","Deaminated glutathione amidase [OS=Homo sapiens]",37,9,18,9,327,35.9,7.74,42,"other metabolic processes","mitochondrion;other cell component","other molecular function","NIT1","ENSG00000158793","","","",959.1,907.8,974.5,983.4,1049.6,1021.3,0.9302949939429657,-0.10423983155340026,0.06328241828984638,1.1987169329574656,0.25018183392765597,0.6017442282613092,1975]
["High","Q86XP3-1","ATP-dependent RNA helicase DDX42 [OS=Homo sapiens]",43,29,100,29,938,102.9,7.02,237.53,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX42","ENSG00000198231","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",3644.2,3344.4,3680.8,3631.7,3675.6,3742.4,0.9655827760029686,-0.05052815325665586,0.31834616590551384,0.4971003763203392,0.5607143838010946,0.25125830296103824,4433]
["High","Q86Y37","CDK2-associated and cullin domain-containing protein 1 [OS=Homo sapiens]",20,6,10,6,369,41,5.19,30.34,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","","other molecular function","CACUL1","ENSG00000151893","","","",228.2,289.1,238.5,237.3,232.2,268.4,1.0242580295432984,0.034579202690696934,0.7992789584813651,0.0973016199535779,0.8882394118733987,0.05146996075094922,7026]
["High","Q86Y91","Kinesin-like protein KIF18B [OS=Homo sapiens]",2,2,2,2,864,94.2,8.79,4.48,"","","","","","","","",228.7,228.2,203.1,182.2,169.1,175.3,1.2533232054690469,0.32575850308711546,0.008633710233039216,2.0638025313461736,0.10152411069212378,0.9934308060555558,664]
["Low","Q86YF9","Zinc finger protein DZIP1 [OS=Homo sapiens]",1,1,1,1,867,98.6,6.15,0,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DZIP1","ENSG00000134874","","Hedgehog 'on' state","",72.5,28.7,74.8,64.3,56.6,67.4,0.9346787041954326,-0.09745757108956893,0.8024448849403599,0.09558478694585354,0.8891002783616192,0.051049253784486395,7047]
["High","Q86YS3","rab11 family-interacting protein 4 [OS=Homo sapiens]",3,2,2,1,637,71.9,4.87,2.45,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB11FIP4","ENSG00000131242","","","Endocytosis",19.4,13.2,24.6,13.4,20.9,13.9,1.1867219917012448,0.24698200054842784,0.5038173589851614,0.2977268729998961,0.6978545217236367,0.15623510316144879,5637]
["High","Q86YZ3","Hornerin [OS=Homo sapiens]",7,5,10,5,2850,282.2,10.04,25.5,"cell organization and biogenesis;developmental processes","non-structural extracellular;plasma membrane;other cytoplasmic organelle;other cell component","other molecular function","HRNR","ENSG00000197915","","Neutrophil degranulation","",353.7,522.8,358.9,404.9,300.6,498.3,1.0262502076756936,0.03738251395208182,0.9011664277165292,0.045194995964009256,0.9447244183150725,0.024694859278660084,7448]
["High","Q8IUD2-1","ELKS/Rab6-interacting/CAST family member 1 [OS=Homo sapiens]",41,43,115,37,1116,128,5.97,231.63,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","ERC1","ENSG00000082805","","","NF-kappa B signaling pathway",4832.1,3804.2,4388.9,4746.3,4404.1,4335.1,0.9658670423788511,-0.05010348812703633,0.6601952405054345,0.18032761092009264,0.801929750757068,0.09586367435276417,6428]
["Low","Q8IUM7","Neuronal pas domain-containing protein 4 [OS=Homo sapiens]",2,1,1,1,802,87.1,4.64,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NPAS4","ENSG00000174576","Orexin receptor pathway","","",20.9,27.2,21.6,26.7,17.4,19.7,1.092476489028213,0.12760223210355356,0.5975469407779221,0.22362797268930948,0.7623605414369308,0.11783959017623524,6120]
["High","Q8IV08","Phospholipase D3 [OS=Homo sapiens]",12,5,19,5,490,54.7,6.47,34.28,"DNA metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","PLD3","ENSG00000105223","","Role of phospholipids in phagocytosis; Synthesis of PG","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways",553.8,452.1,600.6,480.3,546.2,514.8,1.0423019528969053,0.05977328418153467,0.6728439918511846,0.17208562126241855,0.8107354766009335,0.09112082247437653,6480]
["High","Q8IVD9","NudC domain-containing protein 3 [OS=Homo sapiens]",56,15,49,15,361,40.8,5.25,78.44,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","other molecular function","NUDCD3","ENSG00000015676","","","",1169.2,1052,1163.3,1055.4,1010.5,1009.6,1.1004714680539749,0.13812174093083474,0.06594603486424487,1.180811312147151,0.2568112918803112,0.5903858844447167,2005]
["High","Q8IVL5","Prolyl 3-hydroxylase 2 [OS=Homo sapiens]",8,5,9,4,708,80.9,5.71,16.09,"protein metabolism;other metabolic processes;other biological processes","extracellular matrix;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","P3H2","ENSG00000090530","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",120.2,126.6,122.7,123.7,137,138.5,0.9256012024048097,-0.11153735630374711,0.12196180374354985,0.9137761612984759,0.3481819976707997,0.4581936873092901,2735]
["Medium","Q8IVV7","Glucose-induced degradation protein 4 homolog [OS=Homo sapiens]",4,1,1,1,300,33.5,9.16,2.55,"protein metabolism;other metabolic processes","other cell component","other molecular function","GID4","ENSG00000141034","Ciliary landscape","","",34.4,17.7,30.7,29.1,39.1,41.4,0.7554744525547445,-0.40454512546120147,0.2301782045428292,0.6379358018830921,0.4750809994899314,0.3232323385172007,3783]
["Medium","Q8IWB1","Inositol 1,4,5-trisphosphate receptor-interacting protein [OS=Homo sapiens]",1,1,1,1,547,62,5.88,2.41,"other biological processes","plasma membrane;other membranes;nucleus","enzyme regulator activity","ITPRIP","ENSG00000148841","","","",80.2,84,84.8,83.1,68.2,91.6,{"$f":"AVERAGE(T4482:V4482)/AVERAGE(W4482:Y4482)","v":1.0251132153149445},{"$f":"LOG(Z4482,2)","v":0.03578325231957835},{"$f":"TTEST(T4482:V4482,W4482:Y4482,2,2)","v":0.7854261417263603},{"$f":"-LOG10(AB4482)","v":0.10489464798721199},{"$f":"AB4482*7808/AF4482","v":0.8796051799482819},{"$f":"-LOG10(AD4482)","v":0.05571222176653212},6972]
["Medium","Q8IWE2","Protein Noxp20 [OS=Homo sapiens]",4,1,1,1,563,60.7,4.68,0,"","cytosol;ER/Golgi;nucleus","","FAM114A1","ENSG00000197712","","","",21.5,20.1,21.6,26.3,33.9,29.3,0.7061452513966481,-0.5019631239745158,0.01792059095993819,1.7466476728877103,0.1429254077785469,0.8448905600322126,979]
["High","Q8IWR0","Zinc finger CCCH domain-containing protein 7A [OS=Homo sapiens]",19,17,27,17,971,110.5,7.3,67.19,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZC3H7A","ENSG00000122299","","","",1206.1,1137.5,1238.8,1347.5,1298.3,1384.9,0.8887786240603367,-0.17010397587975012,0.018567639332323096,1.731243308436626,0.1455583613521875,0.8369628422016894,996]
["Low","Q8IWV2","Contactin-4 [OS=Homo sapiens]",1,1,2,1,1026,113.4,7.47,4.22,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","other molecular function","CNTN4","ENSG00000144619","","Post-translational modification: synthesis of GPI-anchored proteins","",182.9,118.2,183.5,180,196.6,173.2,0.8814114223353947,-0.18211250206160678,0.3936048720417761,0.4049395345095894,0.6221187937048963,0.20612667877460092,4940]
["High","Q8IWZ6-1","Bardet-Biedl syndrome 7 protein [OS=Homo sapiens]",2,1,1,1,715,80.3,6.05,2.13,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BBS7","ENSG00000138686; ENSGGOG00000002169","Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","BBSome-mediated cargo-targeting to cilium","",29.3,30.5,36.3,35.3,27.4,37.7,0.9571713147410358,-0.0631509331770217,0.7243974576673663,0.14002308254761403,0.8434380181131518,0.0739468269817799,6706]
["Medium","Q8IX21","SMC5-SMC6 complex localization factor protein 2 [OS=Homo sapiens]",1,1,1,1,1173,131.8,8.97,2.07,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","SLF2","ENSG00000119906","","","",61.4,56.5,76.7,73.5,93.5,64.2,0.841695501730104,-0.24862968771956695,0.31268678933826877,0.5048904668181095,0.5557610860808565,0.2551118654247944,4393]
["High","Q8IXI1","Mitochondrial Rho GTPase 2 [OS=Homo sapiens]",27,10,32,9,618,68.1,5.86,88.53,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion","other molecular function","RHOT2","ENSG00000140983","","RHOT2 GTPase cycle","Mitophagy",988.1,957.5,988.6,965.8,941.3,985.4,1.0144165946413137,0.020650251547079782,0.4440603636650309,0.35255798973958974,0.6558016492333196,0.18322749548606582,5287]
["Medium","Q8IXQ4","GPALPP motifs-containing protein 1 [OS=Homo sapiens]",2,1,2,1,340,38.1,5.41,2.83,"","","","GPALPP1","ENSG00000133114","","","",173.3,143.7,132.5,237,157.6,103.5,0.9024292310780968,-0.14811429527077755,0.7104920219627509,0.14844079435439558,0.834213790599272,0.07872263499886475,6650]
["High","Q8IXU6-1","Solute carrier family 35 member f2 [OS=Homo sapiens]",10,2,5,2,374,41.2,6.21,10.53,"transport","other membranes","transporter activity","SLC35F2","ENSG00000110660","","","",172.4,161.5,177.6,197.6,187.2,176.1,0.9119272597610982,-0.133009343049094,0.10275801214833252,0.9881843057424018,0.31863961828998427,0.4967002268556102,2518]
["Medium","Q8IY26","Phospholipid phosphatase 6 [OS=Homo sapiens]",3,1,2,1,295,32.2,9.99,1.67,"other metabolic processes","plasma membrane;other membranes","other molecular function","PLPP6","ENSG00000205808","","Cholesterol biosynthesis","",29,34.2,22.9,31.4,28.7,31.1,0.9440789473684211,-0.08302058676789759,0.6409839475693146,0.19315284656443052,0.790024098282748,0.10235966112525528,6335]
["High","Q8IY67-2","Isoform 2 of Ribonucleoprotein PTB-binding 1 [OS=Homo sapiens]",24,11,49,11,739,77.8,8.84,96.33,"","","","RAVER1","","","","",1498.5,1531.5,1505,1538,1517.6,1585.7,0.9770969340486502,-0.03342640133828245,0.19138789766841363,0.7180855281161361,0.4315208504172606,0.36499821500696156,3463]
["High","Q8IYB7","DIS3-like exonuclease 2 [OS=Homo sapiens]",20,15,30,15,885,99.2,6.1,63.11,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","other cell component","nucleic acid binding activity;other molecular function","DIS3L2","ENSG00000144535","","","",1748.6,1620.1,1700.6,1630.2,1574,1626.4,1.0494141514511652,0.06958415010647113,0.1286471485432158,0.8905998354596267,0.35468818355417686,0.4501532798187228,2832]
["High","Q8IYS1","Peptidase M20 domain-containing protein 2 [OS=Homo sapiens]",6,2,2,2,436,47.7,5.85,0,"protein metabolism;other biological processes","nucleus","other molecular function","PM20D2","ENSG00000146281","","","",37,47.7,42.2,37.3,43.1,43.6,1.0233870967741936,0.033351948566868427,0.8063861789763864,0.09345692440763752,0.8914431948814421,0.049906326000169456,7063]
["High","Q8IYS2-1","Uncharacterized protein KIAA2013 [OS=Homo sapiens]",10,5,6,5,634,69.1,8.19,19.27,"","other membranes","","KIAA2013","ENSG00000116685","","","",207,206.7,192.8,172.1,161.6,162.7,1.2217969379532634,0.28900452987751585,3.0884264121530548E-3,2.51026274212509,0.06058902870877148,1.2176060095401422,398]
["High","Q8IZ40","REST corepressor 2 [OS=Homo sapiens]",37,15,40,15,523,58,9.01,101.75,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","RCOR2","ENSG00000167771","","","",1362.3,1163.6,1301.4,1526.5,1500.2,1435.3,0.8577543702375616,-0.22136352358971845,0.03082222396340935,1.5111360281682036,0.17999994368459254,0.7447276307715525,1337]
["Medium","Q8IZE3","Protein-associating with the carboxyl-terminal domain of ezrin [OS=Homo sapiens]",1,1,1,1,742,82.8,5.05,2.05,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","SCYL3","ENSG00000000457","","","",150.8,89.8,142.7,124.2,128.2,132.2,0.9966198647945919,-0.004884764539379177,0.983132432472849,0.007387976757628346,0.9903622800603799,0.004205908987924486,7751]
["High","Q8IZQ5","Selenoprotein H [OS=Homo sapiens]",34,4,10,4,122,13.4,9.74,17.95,"","ER/Golgi","","SELENOH","ENSG00000211450","Selenium micronutrient network","","",376.7,382.4,414.8,422.3,346.6,368.4,1.0321814824584539,0.045696653730149556,0.6565198411852273,0.18275214423246358,0.7998294460874169,0.09700261115789495,6409]
["High","Q8IZT6-1","Abnormal spindle-like microcephaly-associated protein [OS=Homo sapiens]",3,9,12,9,3477,409.5,10.45,16.43,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","ASPM","ENSG00000066279","","","",385.8,246.9,385.9,274.1,273.4,294.6,1.209595059969125,0.27452415266385327,0.2774188815900734,0.5568639834526636,0.5244761809819112,0.28027423045042926,4130]
["Medium","Q8N0Z8","tRNA pseudouridine synthase-like 1 [OS=Homo sapiens]",4,1,1,1,303,33.2,9.85,2.27,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","PUSL1","ENSG00000169972","","","",90.7,95.7,85.1,92.4,78.3,77.2,1.0951996772892296,0.13119392660500181,0.24462442547559182,0.6115001813158462,0.4927831563760116,0.30734414503593843,3876]
["Medium","Q8N118","Cytochrome P450 4X1 [OS=Homo sapiens]",1,1,1,1,509,58.8,8.48,0,"","other membranes;ER/Golgi","other molecular function","CYP4X1","ENSG00000186377","Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II","","Serotonergic synapse",17.4,13.6,23.9,25.4,23.9,28.8,0.7029449423815621,-0.5085163991367806,0.08144640221034688,1.0891280953297333,0.285044154396409,0.5450878609549357,2231]
["High","Q8N1G1","RNA exonuclease 1 homolog [OS=Homo sapiens]",6,6,6,6,1221,131.4,8.95,10.33,"other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","REXO1","ENSG00000079313","","","Ribosome biogenesis in eukaryotes",357.5,325.9,371.9,321.6,303.7,325.8,1.1095573546419935,0.1499842444785272,0.08404818992867163,1.0754716351389007,0.2880808897994153,0.5404855502233468,2278]
["High","Q8N257","Histone H2B type 3-B [OS=Homo sapiens]",58,9,328,1,126,13.9,10.32,686.55,"cell organization and biogenesis","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","H2BU1","ENSG00000196890; ENSG00000285449","","Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Assembly of the ORC complex at the origin of replication; HATs acetylate histones; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Amyloid fiber formation; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Meiotic synapsis; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; HCMV Early Events; HCMV Late Events; HDACs deacetylate histones","Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis; Systemic lupus erythematosus",716.6,648.2,780.1,789.6,788.5,748.9,0.9217447357112163,-0.11756082309635135,0.20711301296544998,0.6837926134119888,0.4495797623670374,0.34719324657186457,3597]
["High","Q8N2F6-1","Armadillo repeat-containing protein 10 [OS=Homo sapiens]",17,4,6,4,343,37.5,6.61,13.58,"other biological processes","other membranes;mitochondrion;ER/Golgi","other molecular function","ARMC10","ENSG00000170632","","","",311.3,226.5,325.4,278.3,306.4,278.9,0.9995368226030568,-6.6837853448864525E-4,0.9968989173792522,0.001348875640178114,0.99843339493294,6.8090142712656885E-4,7796]
["High","Q8N339","Metallothionein-1M [OS=Homo sapiens]",36,2,12,1,61,6.1,7.69,19.87,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1M","ENSG00000205364","Zinc homeostasis","Metallothioneins bind metals","Mineral absorption",17.9,22.1,19.9,10.7,12.8,16.8,1.4863523573200994,0.5717761642608185,0.03906534849867234,1.4082082970327552,0.19819508841951503,0.7029071122055984,1539]
["High","Q8N3P4-1","Vacuolar protein sorting-associated protein 8 homolog [OS=Homo sapiens]",4,4,5,3,1428,161.7,5.64,6.06,"cell organization and biogenesis;transport","other cytoplasmic organelle","other molecular function","VPS8","ENSG00000156931","","","",14.5,14,15.8,17,15.7,17.2,0.8877755511022042,-0.1717331167822426,0.059002845171998136,1.2291270457696106,0.24247063952787443,0.6153408420638042,1900]
["High","Q8N3X1","Formin-binding protein 4 [OS=Homo sapiens]",13,10,17,10,1017,110.2,4.74,30.6,"","nucleus","","FNBP4","ENSG00000109920; ENSG00000285182","","","",562.2,527.3,526.8,678.2,642.6,689.9,0.8038494056796139,-0.3150028447630045,0.002041712421908497,2.690005428935476,0.05076971525561002,1.2943952723500554,314]
["High","Q8N488","RING1 and YY1-binding protein [OS=Homo sapiens]",41,8,28,8,228,24.8,9.63,46.92,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RYBP","ENSG00000163602","","Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",666.2,1063.9,643.5,602.2,531.6,574.6,1.3893701709201594,0.4744310288381254,0.18349377900411826,0.7363786550630174,0.4227558059793908,0.3739104192417602,3389]
["High","Q8N4C6","ninein [OS=Homo sapiens]",3,6,8,5,2090,243.1,5.03,7.68,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","NIN","ENSG00000100503","","","",88.5,69.9,94.9,97.9,89,88,0.9214259730811205,-0.1180598298004521,0.4259287996473072,0.37066299363124866,0.6476440248580672,0.1886636369059102,5135]
["High","Q8N4V1","Membrane magnesium transporter 1 [OS=Homo sapiens]",25,2,6,2,131,14.7,9.16,13.27,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity","MMGT1","ENSG00000169446","","Miscellaneous transport and binding events","",375,234.2,423.6,371.6,479.1,434,0.8039230948859657,-0.3148705983753996,0.2646592000304977,0.5773130045518673,0.5099849540567931,0.2924426365814748,4052]
["High","Q8N5A5-1","Zinc finger CCCH-type with G patch domain-containing protein [OS=Homo sapiens]",24,8,18,8,531,57.3,5.43,53.91,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZGPAT","ENSG00000197114","","","",757,688.8,805.8,710.7,775.6,706.9,1.0266277585263541,0.037913174571017894,0.6566242940081898,0.18268305313497973,0.7998319013441414,0.09700127799516171,6410]
["High","Q8N5D0-1","WD and tetratricopeptide repeats protein 1 [OS=Homo sapiens]",4,2,2,2,677,75.9,7.27,4.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","WDTC1","ENSCATG00000044454; ENSCSAG00000000989; ENSG00000142784; ENSMFAG00000040733; ENSMNEG00000041566; ENSPANG00000008666; ENSPPAG00000030849; ENSPPYG00000001668","","Neddylation","",58.9,57.1,67,56.3,67.2,78.1,0.9077380952380952,-0.1396519903285117,0.4252581646359807,0.3713473395088935,0.6470022894539629,0.189094182553149,5132]
["High","Q8N5N7","39S ribosomal protein L50, mitochondrial [OS=Homo sapiens]",21,2,2,2,158,18.3,7.88,4.88,"","other membranes;mitochondrion;translational apparatus","","MRPL50","ENSG00000136897","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",28.2,31.4,31.3,34.9,25.9,20.6,1.1167076167076164,0.1592514999278597,0.5026965525181059,0.29869409314371115,0.696920220536465,0.15681693461913154,5632]
["High","Q8N653","Leucine-zipper-like transcriptional regulator 1 [OS=Homo sapiens]",1,1,1,1,840,94.7,6.57,2.7,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LZTR1","ENSG00000099949","22q11.2 copy number variation syndrome","","",29.7,24.6,28.4,28.8,26.1,33.9,0.9313063063063061,-0.10267234717883164,0.5009381811328103,0.3002158654489405,0.6959653591254418,0.1574123763593662,5620]
["High","Q8N6G5-1","chondroitin sulfate N-acetylgalactosaminyltransferase 2 [OS=Homo sapiens]",4,2,2,2,542,62.5,5.73,4.97,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CSGALNACT2","ENSG00000169826; ENSPPAG00000040591; ENSPTRG00000002443","","Chondroitin sulfate biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",80,48,69.1,59.1,65,70.9,1.0107692307692309,0.015453652406512872,0.9475081050170263,0.023417066374016412,0.971139837749139,0.01271823004030845,7618]
["High","Q8N720-1","zinc finger protein 655 [OS=Homo sapiens]",13,6,6,6,491,57.4,7.14,15.03,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF655","ENSG00000197343; ENSPPAG00000041610; ENSPTRG00000048790","Retinoblastoma gene in cancer","Generic Transcription Pathway","",279.1,280.9,298.6,428.1,373.7,403.3,0.7124719940253921,-0.4890947893187991,0.002403231013037099,2.6192044801885865,0.05345990811907029,1.2719717919957751,351]
["High","Q8N8A6","ATP-dependent RNA helicase DDX51 [OS=Homo sapiens]",22,9,22,9,666,72.4,8.16,67.05,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DDX51","ENSG00000185163; ENSG00000288503","","","",483.6,600.9,483.3,477.6,513.7,495.3,1.0546212834656263,0.07672501736278715,0.5406499289404687,0.26708384975447574,0.7219761664387173,0.14147713893312414,5847]
["Low","Q8N8K9","Uncharacterized protein KIAA1958 [OS=Homo sapiens]",1,1,1,1,716,79.2,6.83,2.28,"","","","KIAA1958","ENSG00000165185","","","",79,21.8,60.5,63.5,56.4,57,0.9118145845110233,-0.1331876095348156,0.7750111506687818,0.1106920489271301,0.8716921729216146,0.05963685360388786,6942]
["High","Q8N983","39S ribosomal protein L43, mitochondrial [OS=Homo sapiens]",10,2,5,2,215,23.4,8.65,3.24,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL43","ENSG00000055950","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",138.5,111.4,158.8,156.8,149.8,133.1,0.9294973845803957,-0.1054772891919886,0.5396078491065337,0.267921741730187,0.7215718591922958,0.14172041232283888,5839]
["High","Q8N9N8","probable RNA-binding protein EIF1AD [OS=Homo sapiens]",27,4,8,4,165,19,5.21,14.52,"protein metabolism;other metabolic processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity","EIF1AD","ENSG00000175376","","","",147.1,184.5,143.4,172,141.2,133.1,1.0643065202778401,0.08991370685381758,0.6172442417286086,0.20954295291025526,0.7729660047180394,0.11183960606618126,6235]
["Medium","Q8N9V7","Testis- and ovary-specific PAZ domain-containing protein 1 [OS=Homo sapiens]",1,1,6,1,1692,190.8,7.87,1.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol","","TOPAZ1","ENSG00000173769","","","",178.5,41.6,238.9,217.6,333.9,242.4,0.5781584582441114,-0.7904631426588309,0.17722170880227742,0.7514830802166248,0.4161645420535886,0.3807349251971128,3325]
["High","Q8NB49-1","Phospholipid-transporting ATPase IG [OS=Homo sapiens]",18,14,19,14,1132,129.4,6.67,40.15,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","ATP11C","ENSG00000101974","Complement system in neuronal development and plasticity","Ion transport by P-type ATPases","",588.5,488.4,645.3,642.1,697.6,686.1,0.8501332806792378,-0.23423905563529954,0.10720133296400007,0.969799814500425,0.3264539811945837,0.48617803068856935,2564]
["High","Q8NB90-1","Spermatogenesis-associated protein 5 [OS=Homo sapiens]",19,11,21,10,893,97.8,5.66,36.87,"developmental processes;other biological processes","cytoskeleton;mitochondrion;other cell component","other molecular function","SPATA5","ENSG00000145375","","","Ribosome biogenesis in eukaryotes",670.4,579.1,656.2,614.9,598.4,608.2,1.0462256382102664,0.06519402942562189,0.3844689253805373,0.41513875620359597,0.6147723467891123,0.21128567582908403,4883]
["High","Q8NBJ7-1","Sulfatase-modifying factor 2 [OS=Homo sapiens]",25,7,25,7,301,33.8,8,50.27,"","ER/Golgi","other molecular function","SUMF2","ENSG00000129103","","Glycosphingolipid metabolism; The activation of arylsulfatases","",884.1,984.5,955.2,961.7,921.2,888,1.0190912699844816,0.027283265299027207,0.6554959382634558,0.18342999504213997,0.799705044681416,0.09707016436739174,6400]
["High","Q8NBN3-1","Transmembrane protein 87A [OS=Homo sapiens]",14,5,10,5,555,63.4,6.74,24.09,"transport","other membranes;cytosol;ER/Golgi","","TMEM87A","ENSG00000103978","","RHOA GTPase cycle","",206.7,153.8,187.8,228.6,225.7,230.9,0.8002043199065966,-0.32155967778719996,0.042615800111454966,1.3704293532678977,0.206033540105412,0.686062075276384,1615]
["High","Q8NBT2","kinetochore protein SPC24 [OS=Homo sapiens]",49,8,16,8,197,22.5,4.7,36.98,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","","SPC24","ENSG00000161888","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",464,606.4,495.8,590.9,533.3,533.5,0.9448030403571215,-0.08191448758128858,0.5535179214634542,0.25686831323749915,0.7317758094796225,0.13562195120792342,5906]
["High","Q8NC54","Keratinocyte-associated transmembrane protein 2 [OS=Homo sapiens]",5,1,1,1,265,29.2,5.08,2.85,"","other membranes","","KCT2","ENSG00000113583","","","",23.8,23,24.3,31.9,30.9,37.9,0.7060575968222443,-0.5021422183873693,0.01126641061171665,1.9482144246652788,0.11544374548068714,0.9376295913462439,762]
["High","Q8NC96","adaptin ear-binding coat-associated protein 1 [OS=Homo sapiens]",27,6,17,6,275,29.7,6.8,34.83,"transport","plasma membrane;other membranes;cytosol","","NECAP1","ENSG00000089818","","Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",686.8,610,699,911.2,894.2,878.3,0.7436747773596155,-0.42725625268008843,1.4640444558651452E-3,2.8344457356794104,0.04346486354142606,1.3618616795105327,263]
["High","Q8NCH0","Carbohydrate sulfotransferase 14 [OS=Homo sapiens]",12,4,7,4,376,43,9.48,6.95,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST14","ENSG00000169105","Proteoglycan biosynthesis; Metapathway biotransformation Phase I and II","Dermatan sulfate biosynthesis; Defective CHST14 causes EDS, musculocontractural type","Glycosaminoglycan biosynthesis",39.4,38,36.4,48,45.2,47,0.8116975748930102,-0.3009857917040409,1.7979119432932488E-3,2.7452315826129836,0.04840722914908168,1.3150897758533042,290]
["High","Q8ND30","Liprin-beta-2 [OS=Homo sapiens]",13,8,17,6,876,98.5,6.27,36.09,"cell organization and biogenesis","cytosol;other cell component","other molecular function","PPFIBP2","ENSG00000166387","Ectoderm differentiation","Receptor-type tyrosine-protein phosphatases","",91.8,95.9,98.1,106,89.2,94.8,0.9855172413793102,-0.021046983806480585,0.8037242823579056,0.09489291043940558,0.8900126502128105,0.05060382045781265,7051]
["High","Q8ND76","cyclin-Y [OS=Homo sapiens]",7,2,3,1,341,39.3,7.2,7.6,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","enzyme regulator activity;other molecular function","CCNY","ENSG00000108100","","","",76.9,71.9,91.4,67.6,67.7,71.2,1.1631961259079906,0.21809436939882673,0.1328463316448365,0.8766504334885638,0.3602862651903033,0.4433522937080104,2879]
["High","Q8NDX6","Zinc finger protein 740 [OS=Homo sapiens]",14,3,3,3,193,21.8,9.19,4.23,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF740","ENSG00000139651","","Generic Transcription Pathway","",159.7,218.1,159.2,208,217.9,205.1,0.8510301109350238,-0.23271791699713637,0.19102772892143763,0.7189035874983343,0.43145632265507233,0.3650631623821057,3457]
["High","Q8NE62","Choline dehydrogenase, mitochondrial [OS=Homo sapiens]",5,4,6,4,594,65.3,8.28,8.09,"other metabolic processes","other membranes;mitochondrion","other molecular function","CHDH","ENSG00000016391","Methionine de novo and salvage pathway; One-carbon metabolism and related pathways","Choline catabolism","Glycine, serine and threonine metabolism; Metabolic pathways",320.2,272.7,323.2,344.8,368.3,343.6,0.8669442604334247,-0.20598885551331222,0.06188470405531341,1.2084166815981097,0.2479198405663864,0.6056887160570957,1949]
["Medium","Q8NEE8","Tetratricopeptide repeat protein 16 [OS=Homo sapiens]",1,1,2,1,873,98.2,9.01,0,"","","","TTC16","ENSG00000167094","","","",108.8,121.5,92.2,114.6,99.5,97.3,1.035645472061657,0.05053021611894181,0.7320666870246552,0.13544935543388137,0.846685926868391,0.07227765876406624,6751]
["High","Q8NEN9","PDZ domain-containing protein 8 [OS=Homo sapiens]",9,7,10,7,1154,128.5,6.09,18.93,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PDZD8","ENSG00000165650","","","",219.7,194.2,235.3,171.7,191.7,175.9,1.2037826812534769,0.26757496603741154,0.05264663112561401,1.2786294142290484,0.2304175425049295,0.6374844596105171,1784]
["High","Q8NEY1","neuron navigator 1 [OS=Homo sapiens]",17,24,41,24,1877,202.3,8.07,87.32,"cell organization and biogenesis;developmental processes","cytoskeleton;other cell component","","NAV1","ENSG00000134369","","","",1488.7,1354.5,1548.8,2029.8,1783.8,1879.4,0.7714737396803091,-0.3743110453859477,9.139981529465345E-3,2.0390546819094273,0.1046407269531751,0.9802992519072707,682]
["High","Q8NF99-1","Zinc finger protein 397 [OS=Homo sapiens]",11,4,7,2,534,61.1,7.27,9.32,"other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF397","ENSG00000186812","","","",51.7,61.8,61,49.7,48.6,51.5,1.1648865153538048,0.22018941263826325,0.06986085880170789,1.155766079869997,0.26505033310191217,0.5766716456377755,2058]
["High","Q8NFH3","Nucleoporin Nup43 [OS=Homo sapiens]",20,5,11,5,380,42.1,5.63,29.01,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;nucleus;other cell component","","NUP43","ENSG00000120253","","Separation of Sister Chromatids; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Transport of Ribonucleoproteins into the Host Nucleus; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transport of Mature mRNA derived from an Intron-Containing Transcript; tRNA processing in the nucleus; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis",301.3,204,303,264.5,251.8,237.5,1.0723003449190767,0.10070905265801132,0.6178058394656321,0.2091479910884433,0.7735452204213686,0.111514292946612,6236]
["High","Q8NFP7","Diphosphoinositol polyphosphate phosphohydrolase 3-alpha [OS=Homo sapiens]",27,4,6,1,164,18.5,5.68,15.96,"other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT10","ENSG00000122824","","Synthesis of pyrophosphates in the cytosol","",36.4,43.4,54.8,57.4,62.3,59.4,0.7515354550530431,-0.41208692737564395,0.0555805166397763,1.2550774206251967,0.23598296570058366,0.6271193452046389,1839]
["High","Q8NFY9","Kelch repeat and BTB domain-containing protein 8 [OS=Homo sapiens]",5,3,4,3,601,68.8,6.29,7.76,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","","KBTBD8","ENSG00000163376","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",216.3,210.1,219,183.9,199.4,193,1.1199028283879924,0.1633735581002588,0.011516883847584664,1.9386650131757324,0.11588122304373849,0.9359869297752854,776]
["High","Q8NG48-1","protein Lines homolog 1 [OS=Homo sapiens]",2,2,7,1,757,85.8,6.52,9.69,"other biological processes","","","LINS1","ENSG00000140471","","","",87,104.5,101.9,93.4,65.3,84.2,1.2079044874433924,0.272506381037525,0.16450343178228144,0.7838250376011692,0.4007621826383942,0.39711326679737,3205]
["High","Q8NHP6-1","motile sperm domain-containing protein 2 [OS=Homo sapiens]",20,7,12,7,518,59.7,5.96,23.2,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","MOSPD2","ENSG00000130150","","Neutrophil degranulation; RHOD GTPase cycle","",484.3,422.2,505.4,507.4,459.3,461.2,0.9887947335247567,-0.016257035643811014,0.865368952170283,0.06279869053665545,0.9260965979366186,0.03334371119837983,7296]
["High","Q8NI36","WD repeat-containing protein 36 [OS=Homo sapiens]",15,13,37,13,951,105.3,7.53,67.35,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","WDR36","ENSG00000134987","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1395.7,1351.4,1455.1,1453,1615.3,1614,0.8974649210857913,-0.15607254499301954,0.06042699008666826,1.2187690377440383,0.24509814992036663,0.6106599669299225,1925]
["Medium","Q8TAD4-1","Zinc transporter 5 [OS=Homo sapiens]",1,1,1,1,765,84,7.31,2.25,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A5","ENSG00000145740","Zinc homeostasis","Insulin processing; Zinc efflux and compartmentalization by the SLC30 family","",54.9,63.6,67,50.5,69.4,57.8,1.043894203714125,0.06197550547948757,0.7128015203637788,0.14703138264557075,0.8352925515534121,0.07816139125507174,6663]
["High","Q8TAD7","Overexpressed in colon carcinoma 1 protein [OS=Homo sapiens]",19,1,1,1,63,6.4,6.57,2.01,"","","","OCC1","ENSG00000235162","","","",16.4,9,14.5,15.8,15,13.5,0.9006772009029346,-0.15091795233267247,0.5614380442505256,0.25069816197542755,0.7378738006241549,0.13201790969347912,5941]
["High","Q8TB52","F-box only protein 30 [OS=Homo sapiens]",5,3,4,3,745,82.3,5.4,12.41,"protein metabolism;other metabolic processes","cytosol","other molecular function","FBXO30","ENSG00000118496","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",145.9,132.3,127.7,163.7,138,148.4,0.9017996000888693,-0.14912122468785788,0.1864225659652464,0.7295015185860472,0.4268584736236492,0.36971609291990953,3410]
["Medium","Q8TBC5","Zinc finger and SCAN domain-containing protein 18 [OS=Homo sapiens]",1,1,1,1,510,54.8,4.82,2.35,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZSCAN18","ENSG00000121413","","","",161.9,162.6,144.9,135.2,141.5,126.2,1.165053363117399,0.22039603637457184,0.03843382286046983,1.4152864158313765,0.19613809731669832,0.7074380419903399,1530]
["Medium","Q8TBF5-1","Phosphatidylinositol-glycan biosynthesis class X protein [OS=Homo sapiens]",7,1,1,1,258,28.8,6.33,0,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","","PIGX","ENSG00000163964","3q29 copy number variation syndrome","Synthesis of glycosylphosphatidylinositol (GPI)","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways",75.4,84.3,66.7,64.6,39,60.4,1.3804878048780487,0.4651781433264362,0.0917078664460428,1.0375934101578774,0.3027716791588593,0.5188847505730724,2365]
["High","Q8TC12","Retinol dehydrogenase 11 [OS=Homo sapiens]",17,5,11,5,318,35.4,8.82,21.05,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","RDH11","ENSG00000072042","","RA biosynthesis pathway; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision)","Retinol metabolism; Metabolic pathways; Biosynthesis of cofactors",490.9,390.5,572.7,470.2,571,534,0.9231208735398678,-0.11540852801399763,0.5402271861902348,0.26742356432606296,0.7219055056945668,0.14151964597769506,5843]
["High","Q8TCA0-1","Leucine-rich repeat-containing protein 20 [OS=Homo sapiens]",6,1,1,1,184,20.5,6.55,3.47,"","","","LRRC20","ENSG00000172731; ENSPTRG00000002588","","","",25.9,18.1,24,25.8,32.7,22.4,0.8405438813349815,-0.2506049562922758,0.3247750144626476,0.48841738921653227,0.5657838716921804,0.2473494367569393,4482]
["High","Q8TCG2","Phosphatidylinositol 4-kinase type 2-beta [OS=Homo sapiens]",17,8,10,7,481,54.7,5.97,18.49,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","kinase activity;other molecular function","PI4K2B","ENSG00000038210","","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane; Synthesis of PIPs at the early endosome membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",241.7,194.2,272.5,268.1,268.1,290.2,0.8572120038722167,-0.22227604211314544,0.17566885479312994,0.7553052299132054,0.41463797407036235,0.38233092613507896,3308]
["High","Q8TCZ2","CD99 antigen-like protein 2 [OS=Homo sapiens]",8,2,3,2,262,28,5.14,6.32,"cell adhesion","plasma membrane;other membranes","","CD99L2","ENSG00000102181","","Cell surface interactions at the vascular wall","Cell adhesion molecules; Leukocyte transendothelial migration",141.4,123.7,146.2,185.2,174.1,209.7,0.7228471001757469,-0.4682375806935622,0.013808801836261148,1.8598440027012164,0.12580994718497907,0.9002850199657793,857]
["Medium","Q8TD31-1","Coiled-coil alpha-helical rod protein 1 [OS=Homo sapiens]",1,1,1,1,782,88.6,5.95,1.83,"transport;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CCHCR1","ENSG00000204536; ENSG00000206355; ENSG00000206457; ENSG00000234114","","","",38.6,31,46.8,76.4,70.9,71.6,0.531749657377798,-0.9111808962726625,2.1882372571385266E-3,2.659905591899903,0.05161859970917709,1.2871937810169864,331]
["High","Q8TD55","pleckstrin homology domain-containing family O member 2 [OS=Homo sapiens]",19,7,12,7,490,53.3,5.43,28.78,"","non-structural extracellular;other cell component","","PLEKHO2","ENSG00000241839","","Neutrophil degranulation","",426.2,588.3,483.3,524.8,384.4,415.1,1.131012610435702,0.1776150150144063,0.4159000298211386,0.3810110484949955,0.6398714153386109,0.19390729042161062,5075]
["High","Q8TDJ6-1","DmX-like protein 2 [OS=Homo sapiens]",2,4,5,3,3036,339.4,6.38,7.05,"other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","DMXL2","ENSG00000104093","","","Lysosome",30.7,17.4,33.2,43.9,33,36.9,0.7144112478031633,-0.48517330023155436,0.13764456158932747,0.8612409431402782,0.3669268476918638,0.43542051016324146,2929]
["High","Q8TDY2-1","RB1-inducible coiled-coil protein 1 [OS=Homo sapiens]",17,23,35,23,1594,183,5.41,54.38,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RB1CC1","ENSG00000023287","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Malignant pleural mesothelioma; Alzheimer's disease","Macroautophagy","Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",1364.3,1085.6,1349.4,1308.3,1293.6,1268.5,0.9816298057048367,-0.026749039967913286,0.8079192165577559,0.09263206194465066,0.8922536411432755,0.04951167108291467,7070]
["High","Q8TE77","Protein phosphatase Slingshot homolog 3 [OS=Homo sapiens]",14,6,9,6,659,73,5.3,13.74,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SSH3","ENSG00000172830","Regulation of actin cytoskeleton","","Axon guidance; Regulation of actin cytoskeleton",278,254.8,260.9,322.9,317.1,280.7,0.8620614749647006,-0.21413734104359375,0.04699986084946299,1.3279034278600237,0.21817771314661535,0.6611896146632817,1682]
["High","Q8TEH3","DENN domain-containing protein 1A [OS=Homo sapiens]",16,11,18,11,1009,110.5,6.96,32.4,"transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DENND1A","ENSG00000119522","","RAB GEFs exchange GTP for GDP on RABs","",612.1,567,716.5,658.8,624.2,639,0.9862643080124871,-0.019953770028511748,0.8557350640245635,0.06766067228745273,0.920074274291351,0.03617711220569087,7262]
["High","Q8TEU7","Rap guanine nucleotide exchange factor 6 [OS=Homo sapiens]",6,6,7,5,1601,179.3,6.4,13.78,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","RAPGEF6","ENSG00000158987","","","Rap1 signaling pathway; Tight junction",112.5,97.6,112.5,125.3,116.8,117.8,0.8963601000277857,-0.1578496637690846,0.09237727236343238,1.0344348653737183,0.3036975758373389,0.5175586746759684,2375]
["High","Q8TF09","Dynein light chain roadblock-type 2 [OS=Homo sapiens]",13,1,2,1,96,10.8,7.5,4.85,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DYNLRB2","ENSG00000168589","Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome","Intraflagellar transport","Salmonella infection",89.3,105.4,85.7,112.1,92.8,84.3,0.9695712309820194,-0.044581202940494634,0.788230618989504,0.10334669887931644,0.8813553878089714,0.054848936261697546,6983]
["High","Q8TF46","DIS3-like exonuclease 1 [OS=Homo sapiens]",4,3,3,3,1054,120.7,6.54,4.64,"RNA metabolism OR transcription;other metabolic processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","DIS3L","ENSG00000166938","","","RNA degradation",102.9,125.2,123.5,108.8,104.1,119.6,1.0574436090225565,0.08058072986748994,0.49595797823331156,0.30455511906325133,0.6938612961916676,0.15872733692127639,5581]
["Medium","Q8WTW4","GATOR complex protein NPRL2 [OS=Homo sapiens]",2,1,1,1,380,43.6,6.52,0,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;kinase activity","NPRL2","ENSG00000114388","22q11.2 copy number variation syndrome","Amino acids regulate mTORC1","mTOR signaling pathway",25.4,16.2,28.1,32.8,27.7,29.3,0.7761692650334074,-0.3655567888727241,0.16127862108920782,0.7924231983788403,0.3971187238929469,0.4010796357472937,3171]
["High","Q8WU90","Zinc finger CCCH domain-containing protein 15 [OS=Homo sapiens]",50,22,60,22,426,48.6,5.31,136.13,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","other molecular function","ZC3H15","ENSG00000065548","VEGFA-VEGFR2 signaling pathway","","",3260.2,3072.3,3138.5,3689.5,3288.6,3055.7,0.9439095856006697,-0.08327942031358895,0.3863003695432144,0.41307487639956986,0.6155578133455956,0.21073115176944807,4900]
["High","Q8WUD6-1","Cholinephosphotransferase 1 [OS=Homo sapiens]",4,1,1,1,406,45.1,6.92,2.1,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","CHPT1","ENSG00000111666","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids","Synthesis of PC","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways; Choline metabolism in cancer",9.7,12.7,11.3,13.7,11.3,17.3,0.7966903073286052,-0.3279090719380912,0.21492379687971594,0.6677154957166715,0.4575040910678359,0.33960501805601967,3668]
["High","Q8WUI4","histone deacetylase 7 [OS=Homo sapiens]",4,3,4,3,952,102.9,7.58,9.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","HDAC7","ENSG00000061273","MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling pathway; Ethanol effects on histone modifications; Gastrin signaling pathway","Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway","Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis",124.8,136,133.2,135.7,137.9,141.2,0.9498553519768563,-0.07422026446948705,0.13623022919409225,0.8657265127205893,0.3656533618245006,0.43693042930901316,2909]
["High","Q8WUN7","Ubiquitin domain-containing protein 2 [OS=Homo sapiens]",12,2,2,2,234,26.2,5.67,5.68,"","other cell component","","UBTD2","ENSG00000168246","","","",39.3,32.3,48.9,48.2,46.4,44.3,0.867530597552196,-0.20501345286406836,0.2823746117205304,0.5491743532481969,0.5293591760657627,0.2762495543323678,4165]
["High","Q8WUY8","N-acetyltransferase 14 [OS=Homo sapiens]",11,1,2,1,206,21.6,10.74,7.22,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus","nucleic acid binding activity;other molecular function","NAT14","ENSG00000090971","Metapathway biotransformation Phase I and II","","",12,12.7,8.9,14.7,17.3,16.1,0.6985446985446986,-0.5175756609912816,0.025326336044849615,1.596427634946919,0.1654795245507831,0.7812557355724401,1195]
["High","Q8WV74","Nucleoside diphosphate-linked moiety X motif 8 [OS=Homo sapiens]",6,1,1,1,236,25.4,8.41,4.51,"other metabolic processes","mitochondrion","other molecular function","NUDT8","ENSG00000167799","","","",29.4,42.2,32.5,37,39.9,46.3,0.8449675324675323,-0.24303218739548454,0.24986042508657977,0.6023025254964772,0.49717385297553895,0.3034917195457527,3924]
["High","Q8WVD3-1","E3 ubiquitin-protein ligase RNF138 [OS=Homo sapiens]",8,2,2,2,245,28.2,6.93,2.4,"cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction","other cell component","nucleic acid binding activity;other molecular function","RNF138","ENSG00000134758; ENSGGOG00000027857; ENSPPYG00000009094; ENSPTRG00000009956","","Antigen processing: Ubiquitination & Proteasome degradation","",92.8,112.8,89.9,109.8,93.4,108.9,0.9468119192566484,-0.0788502268543156,0.5700036723854829,0.24412234627204743,0.742631182043359,0.12922681930989693,5993]
["Medium","Q8WVL7","ankyrin repeat domain-containing protein 49 [OS=Homo sapiens]",5,1,1,1,239,27.3,5.15,2.54,"other biological processes","nucleus","","ANKRD49","ENSG00000168876","","","",22.6,16.2,26.2,22,20.6,28.8,0.9103641456582633,-0.13548435611328288,0.6106630250743748,0.21419837522650984,0.7697863900194895,0.11362977158864243,6194]
["High","Q8WVQ1","Soluble calcium-activated nucleotidase 1 [OS=Homo sapiens]",9,3,5,3,401,44.8,6.09,12.48,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","CANT1","ENSG00000171302","Proteoglycan biosynthesis","Neutrophil degranulation","Purine metabolism; Pyrimidine metabolism; Metabolic pathways",244.1,218.3,244.7,193.6,224.7,224.9,1.099347014925373,0.13664685279239489,0.19133193262471787,0.7182125417062664,0.43176870807335177,0.36474883584040757,3460]
["Medium","Q8WW35","Tctex1 domain-containing protein 2 [OS=Homo sapiens]",13,1,1,1,142,16.1,4.93,0,"cell organization and biogenesis;transport;other biological processes","cytoskeleton;other cell component","other molecular function","DYNLT2B","ENSG00000213123","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 3q29 copy number variation syndrome","Intraflagellar transport","",32.6,27.8,31.3,31.5,36.2,29.7,0.9414784394250513,-0.08700003848728788,0.4745977530973798,0.32367432220742665,0.6772038114371969,0.16928060626085106,5472]
["High","Q8WWM7-1","ataxin-2-like protein [OS=Homo sapiens]",30,26,79,25,1075,113.3,8.59,155.2,"cell organization and biogenesis;other biological processes","other membranes;cytosol;nucleus;other cell component","","ATXN2L","ENSG00000168488","16p11.2 distal deletion syndrome","","Amyotrophic lateral sclerosis; Spinocerebellar ataxia; Pathways of neurodegeneration",3705,3912.4,3655,4245.8,3577,3617.5,0.9853238114385113,-0.021330172972696692,0.8200175753209262,0.08617683934421222,0.9000136671500973,0.045750895535338315,7114]
["High","Q8WX77","Insulin-like growth factor-binding protein-like 1 [OS=Homo sapiens]",3,1,4,1,278,29,7.93,5.24,"other biological processes","non-structural extracellular","other molecular function","IGFBPL1","ENSG00000137142","","","",222.9,212.7,188.3,246.3,226.6,220.3,0.9000288517022504,-0.15195684506661747,0.14808561135937776,0.8294871373653544,0.37947241663735526,0.42081978692939265,3047]
["High","Q8WXE1","ATR-interacting protein [OS=Homo sapiens]",8,3,17,3,791,85.8,6.32,5.94,"DNA metabolism;other metabolic processes;stress response;signal transduction","nucleus","other molecular function","ATRIP","ENSG00000164053","miRNA regulation of DNA damage response; ATR signaling; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Fanconi Anemia Pathway; Activation of ATR in response to replication stress; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA)","Fanconi anemia pathway",507.9,396.1,500.1,509.2,423.9,495.2,0.9830567807883498,-0.024653346687757847,0.8655014596127192,0.06273219537817122,0.9258577060770121,0.03345575437001672,7299]
["High","Q8WXF7","Atlastin-1 [OS=Homo sapiens]",9,4,5,3,558,63.5,6.18,6.09,"cell organization and biogenesis;developmental processes","other membranes;ER/Golgi;other cell component","other molecular function","ATL1","ENSG00000198513","","","",108.6,120.8,97.1,113.4,91.3,109.3,1.039808917197452,0.056318432654803526,0.6877942302141196,0.16254147171941374,0.8201431505057798,0.08611033780068214,6548]
["High","Q8WXW3","Progesterone-induced-blocking factor 1 [OS=Homo sapiens]",11,8,9,8,757,89.8,6.02,21.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding","PIBF1","ENSG00000083535","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","","",322.3,314.9,370.1,416.7,382.2,409.1,0.8338576158940398,-0.2621270354145391,0.029686847985704187,1.52743591136606,0.17775683211071955,0.7501736981033261,1304]
["High","Q8WY22","BRI3-binding protein [OS=Homo sapiens]",10,2,3,2,251,27.8,9.44,9.3,"","other membranes;mitochondrion","","BRI3BP","ENSG00000184992","","","",149,150.9,169.8,139.8,138.7,142.1,1.1167379933428434,0.15929074352600808,0.07139969712270423,1.1463036304957757,0.2672525575906398,0.5730781299276524,2086]
["High","Q8WYL5-1","Protein phosphatase Slingshot homolog 1 [OS=Homo sapiens]",3,2,2,2,1049,115.4,6.25,0,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SSH1","ENSG00000084112","Regulation of actin cytoskeleton","","Axon guidance; Regulation of actin cytoskeleton",43.6,40.3,31.7,40.7,37.2,36.7,1.0087260034904015,0.012534353743774145,0.9336820071843333,0.029801010322255687,0.9653322447160055,0.015323186953632856,7552]
["High","Q8WZA9","Immunity-related GTPase family Q protein [OS=Homo sapiens]",29,10,21,10,623,62.7,4.88,52.89,"","","other molecular function","IRGQ","ENSG00000167378","","","",369.4,388,359.8,361.6,339.8,330.9,1.082243533856437,0.1140251808218123,0.08313747758417034,1.080203156253838,0.2879935337077205,0.5406172633052903,2254]
["High","Q92503-1","SEC14-like protein 1 [OS=Homo sapiens]",12,6,8,6,715,81.2,6.43,13.9,"stress response;transport;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding","SEC14L1","ENSG00000129657","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","",346.2,259.1,336,389.2,420.5,402.8,0.7763298969072164,-0.3652582472512391,0.035423012113884905,1.4507145123492196,0.1903529790675935,0.7204403219886056,1453]
["High","Q92530","proteasome inhibitor PI31 subunit [OS=Homo sapiens]",9,1,7,1,271,29.8,5.74,13.62,"protein metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMF1","ENSG00000125818","","Regulation of expression of SLITs and ROBOs; Neddylation; Ub-specific processing proteases; Separation of Sister Chromatids; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; ER-Phagosome pathway; Downstream TCR signaling; UCH proteinases; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome",29.3,24,24.9,24.4,24,19.5,1.1516936671575844,0.2037570330626201,0.204812835140001,0.6886428306268159,0.44744785024429995,0.3492575741378059,3574]
["High","Q92542-1","Nicastrin [OS=Homo sapiens]",19,10,31,10,709,78.4,5.99,46.36,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","NCSTN","ENSG00000162736; ENSGGOG00000003518","Alzheimer's disease and miRNA effects; Notch signaling; Inclusion body myositis; Alzheimer's disease; Notch signaling pathway","Neutrophil degranulation; Amyloid fiber formation; Degradation of the extracellular matrix; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; Nuclear signaling by ERBB4; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3","Notch signaling pathway; Alzheimer disease",1060.9,928.2,1090.6,1053.5,1139.7,1078.8,0.9412286063569681,-0.08738292644778786,0.31692930769718475,0.4990375980371072,0.5591016797333074,0.2525092029697109,4426]
["High","Q92574-1","Hamartin [OS=Homo sapiens]",21,18,32,18,1164,129.7,6.47,43.57,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TSC1","ENSG00000165699","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Glioblastoma signaling pathways; Nanoparticle triggered autophagic cell death; Wnt signaling pathway; BDNF-TrkB signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; CAMKK2 pathway; Malignant pleural mesothelioma","TP53 Regulates Metabolic Genes; Macroautophagy; TBC/RABGAPs; Energy dependent regulation of mTOR by LKB1-AMPK; Inhibition of TSC complex formation by PKB","Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Cellular senescence; Thermogenesis; Insulin signaling pathway; Human cytomegalovirus infection; Human papillomavirus infection; Herpes simplex virus 1 infection; Choline metabolism in cancer",1173.8,1202.6,1220,1176.2,1158.6,1158.5,1.029513640397332,0.04196294488344479,0.0795657847856281,1.0992736492636985,0.2822579044098974,0.549353887158411,2201]
["High","Q92581-1","Sodium/hydrogen exchanger 6 [OS=Homo sapiens]",2,1,1,1,669,74.1,6.48,3.74,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","SLC9A6","ENSG00000198689","","Sodium/Proton exchangers; Defective SLC9A6 causes  X-linked, syndromic mental retardation,, Christianson type (MRXSCH)","Cardiac muscle contraction",57.5,21.8,50.7,52.6,55.2,47.4,0.8376288659793814,-0.255616934271311,0.49430016065232485,0.3060092483893004,0.692658947303186,0.15948055148259088,5572]
["High","Q92613","protein jade-3 [OS=Homo sapiens]",4,3,7,3,823,93.7,7.18,2.9,"protein metabolism;other metabolic processes","nucleus","other molecular function","JADE3","ENSG00000102221","","HATs acetylate histones","",96.6,78.6,99.6,104.6,113.3,110,0.8380603842634948,-0.25487389757496093,0.06552768682351098,1.1835751626941926,0.2555645248341527,0.592499431178857,2002]
["High","Q92618","Zinc finger protein 516 [OS=Homo sapiens]",9,10,12,10,1163,124.2,8.72,24.97,"stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF516","ENSG00000101493","Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects","","Thermogenesis",608.6,653.4,575.9,642.1,618.4,656.4,0.9587876258542438,-0.060716805251502505,0.3524222823842388,0.4529366405250646,0.5901164874235763,0.22906225132092134,4663]
["High","Q92665","28S ribosomal protein S31, mitochondrial [OS=Homo sapiens]",26,8,14,8,395,45.3,9.29,34.3,"","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS31","ENSG00000102738","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",443.1,481.5,488.3,606.4,502.7,563.2,0.8448842910960953,-0.24317432046560525,0.05978496725750168,1.2234080042699298,0.24388768252172055,0.6128101330521191,1914]
["High","Q92729-1","Receptor-type tyrosine-protein phosphatase U [OS=Homo sapiens]",1,1,1,1,1446,162.3,6.92,2.6,"cell adhesion;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PTPRU","ENSG00000060656","EPO receptor signaling","Signaling by SCF-KIT","",43.7,33.3,38.4,42.7,47.5,47.2,0.8398835516739447,-0.2517387801726177,0.0958507670710798,1.0184044072157132,0.30964120367852344,0.5091412529647282,2417]
["High","Q92738-1","USP6 N-terminal-like protein [OS=Homo sapiens]",4,2,2,2,828,94,9.07,7.22,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","USP6NL","ENSG00000148429","EGF/EGFR signaling pathway","Retrograde transport at the Trans-Golgi-Network","",104.9,100.8,107.1,101.5,120.4,117.2,{"$f":"AVERAGE(T5186:V5186)/AVERAGE(W5186:Y5186)","v":0.92244175759363},{"$f":"LOG(Z5186,2)","v":-0.1164702717180789},{"$f":"TTEST(T5186:V5186,W5186:Y5186,2,2)","v":0.2255975138906164},{"$f":"-LOG10(AB5186)","v":0.6466656906352197},{"$f":"AB5186*7808/AF5186","v":0.46959887722152305},{"$f":"-LOG10(AD5186)","v":0.32827295012730706},3751]
["High","Q92793-1","CREB-binding protein [OS=Homo sapiens]",10,18,33,12,2442,265.2,8.53,61.8,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CREBBP","ENSG00000005339","Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL-6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RORA activates gene expression; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; SUMOylation of transcription cofactors; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; Formation of the beta-catenin:TCF transactivating complex; Estrogen-dependent gene expression; HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production","cAMP signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Cell cycle; Wnt signaling pathway; Notch signaling pathway; TGF-beta signaling pathway; Adherens junction; JAK-STAT signaling pathway; Long-term potentiation; Melanogenesis; Thyroid hormone signaling pathway; Glucagon signaling pathway; Growth hormone synthesis, secretion and action; Huntington disease; Tuberculosis; Hepatitis B; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Renal cell carcinoma; Prostate cancer",1103.9,938.7,1042.8,1195.9,1197.2,1255.1,0.8457321418781865,-0.2417272858841048,0.022638532214040608,1.6451517343745412,0.15712147513531471,0.8037644521632872,1125]
["High","Q92802-1","NEDD4-binding protein 2-like 2 [OS=Homo sapiens]",4,3,3,3,583,67.4,6.39,2.14,"developmental processes;other biological processes","nucleus;other cell component","other molecular function","N4BP2L2","ENSG00000244754","","","",175.7,171.7,193.1,273.1,266,268.9,0.6689356435643564,-0.5800606750171445,2.0502699177130649E-4,3.6881889603799687,0.020790269503251444,1.6821398808938153,77]
["High","Q92834","X-linked retinitis pigmentosa GTPase regulator [OS=Homo sapiens]",3,2,2,1,1020,113.3,4.86,2.16,"cell organization and biogenesis;transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity","RPGR","ENSG00000156313","Ciliary landscape","","",12.4,21.1,22.2,22.3,24,18.2,0.8635658914728682,-0.21162183297058473,0.4545543490829592,0.3424141826385259,0.6632704835805916,0.1783093289541453,5351]
["High","Q92882","osteoclast-stimulating factor 1 [OS=Homo sapiens]",21,3,6,3,214,23.8,5.68,13.39,"signal transduction;other biological processes","other cell component","other molecular function","OSTF1","ENSG00000134996","","Neutrophil degranulation","",153.9,164.9,188.2,145.3,131.7,140.7,1.213789801292794,0.27951860372791015,0.052013096909733,1.2838872871448608,0.22931578806956252,0.6395660436763002,1771]
["High","Q92888-1","Rho guanine nucleotide exchange factor 1 [OS=Homo sapiens]",18,13,24,13,912,102.4,5.66,48.85,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","ARHGEF1","ENSG00000076928","G protein signaling pathways; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway","G alpha (12/13) signalling events; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK","Vascular smooth muscle contraction; Platelet activation; Regulation of actin cytoskeleton; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis",832.2,808.5,855.1,884,874.6,878.6,0.9463825269224937,-0.07950465746808957,0.02644072971563694,1.577726563289977,0.16866766145399772,0.772968176440884,1224]
["High","Q92922","SWI/SNF complex subunit SMARCC1 [OS=Homo sapiens]",47,52,215,42,1105,122.8,5.76,457.93,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","SMARCC1","ENSG00000173473","Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",10735,10730.4,10124.6,10931.7,10419,10833.6,0.9815344748837166,-0.026889153869069586,0.4829744142015483,0.3160758755950782,0.6849008765139283,0.16437227799375426,5506]
["High","Q92993-1","Histone acetyltransferase KAT5 [OS=Homo sapiens]",7,4,4,4,513,58.5,8.48,8.03,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","HTATIP; KAT5","ENSANAG00000035412; ENSCANG00000040731; ENSCCAG00000033565; ENSG00000172977; ENSGGOG00000003283; ENSMLEG00000035009; ENSMNEG00000035393; ENSPANG00000021813; ENSPPAG00000042045; ENSPPYG00000003052; ENSPTRG00000003890; ENSRBIG00000038205; ENSRROG00000042827; ENSSBOG00000020725","Androgen receptor signaling pathway; ATM signaling in development and disease ; Joubert syndrome; Gastrin signaling pathway; Androgen receptor signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex; Estrogen-dependent gene expression; DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; HDR through Single Strand Annealing (SSA); Sensing of DNA Double Strand Breaks","Spinocerebellar ataxia; Human T-cell leukemia virus 1 infection",102.5,95.7,98.5,117.4,109.6,105.9,0.8912586362270952,-0.16608394365999615,0.037048270818072666,1.4312320573660124,0.19349357762375344,0.7133334453678255,1495]
["High","Q92995","Ubiquitin carboxyl-terminal hydrolase 13 [OS=Homo sapiens]",22,14,33,13,863,97.3,5.53,55.16,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","USP13","ENSG00000058056","","Ub-specific processing proteases; Regulation of PTEN stability and activity","",686.3,664.2,733.5,784.4,796.4,836.4,0.8621545589938773,-0.21398156953380074,0.012570178465699645,1.90065855635395,0.12057488140071601,0.9187431565845158,814]
["High","Q93073-1","Selenocysteine insertion sequence-binding protein 2-like [OS=Homo sapiens]",2,2,2,2,1101,121.7,6.04,5.06,"protein metabolism;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","KIAA0256; SECISBP2L","ENSG00000138593; ENSGGOG00000007289","Thyroid hormones production and peripheral downstream signaling effects","","",67.5,93.6,69.2,81.9,77.4,68,1.0131984161900571,0.018916726974997713,0.9201701981371355,0.03613183648546018,0.9559192265905739,0.019578803255312804,7516]
["High","Q969E2-1","Secretory carrier-associated membrane protein 4 [OS=Homo sapiens]",12,3,7,3,229,25.7,8.82,13.33,"transport","other membranes;ER/Golgi;other cytoplasmic organelle","","SCAMP4","ENSG00000227500; ENSPPAG00000030995; ENSPTRG00000042465","","","",299.6,325.3,316.7,298.2,269.2,299.2,1.086545118855297,0.11974808376657607,0.1140553504443833,0.942884336744476,0.3361812669949961,0.4734264903830716,2649]
["High","Q969E8","pre-rRNA-processing protein TSR2 homolog [OS=Homo sapiens]",11,2,3,2,191,20.9,4.39,4.37,"RNA metabolism OR transcription;other metabolic processes","","","TSR2","ENSG00000158526","","","",86.4,93.7,80.6,73.6,70.5,73.7,1.196969696969697,0.25938662881864955,0.022040248336533185,1.6567835164183282,0.1551760676390001,0.8091752579088528,1109]
["High","Q969M3","Protein YIPF5 [OS=Homo sapiens]",5,1,2,1,257,28,4.36,5.15,"transport;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","","YIPF5","ENSG00000145817","","","",178.6,173.4,177.1,168.8,156.5,169.3,1.0697533360291145,0.09727817801740145,0.06149891254073505,1.211132563602365,0.2470079779413885,0.6072890195339854,1944]
["High","Q969S9","Ribosome-releasing factor 2, mitochondrial [OS=Homo sapiens]",5,5,5,4,779,86.5,6.51,9.43,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","other molecular function","GFM2","ENSG00000164347","","Mitochondrial translation termination","",299.1,263.6,286.6,323.7,298.6,310.4,0.9105821807655196,-0.1351388674353169,0.09334190938150964,1.0299233195278705,0.30519833687220577,0.5154178373265664,2388]
["High","Q969V3","Nicalin [OS=Homo sapiens]",19,9,35,9,563,62.9,6.89,107.04,"protein metabolism;other biological processes","other membranes;ER/Golgi;other cell component","translation activity;other molecular function","NCLN","ENSG00000125912","","","",864,765.4,882.9,860.9,869.7,899.1,0.9553561242727309,-0.0658894738324935,0.36370352206448786,0.4392524932654265,0.5976003998904716,0.22358912057992822,4752]
["High","Q969Z3-1","Mitochondrial amidoxime reducing component 2 [OS=Homo sapiens]",7,2,7,1,335,38,9.16,17.82,"other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;other cytoplasmic organelle","other molecular function","MTARC2","ENSG00000117791","","Phase I - Functionalization of compounds","",109.6,131.4,94.2,88.5,94.3,98.1,1.1933072267710931,0.2549655245729535,0.17974151010509246,0.745351613888542,0.4195580600599587,0.3772079313337485,3345]
["High","Q96A54","adiponectin receptor protein 1 [OS=Homo sapiens]",8,2,2,2,375,42.6,7.02,4.36,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","ADIPOR1","ENSG00000159346","AMP-activated protein kinase (AMPK) signaling; Leptin and adiponectin; Nonalcoholic fatty liver disease","AMPK inhibits chREBP transcriptional activation activity","AMPK signaling pathway; Longevity regulating pathway; Adipocytokine signaling pathway; Non-alcoholic fatty liver disease; Alcoholic liver disease",42.5,46.9,37.9,33,32.3,34.3,1.2781124497991971,0.3540147718332774,0.025663767587898394,1.5906795863662504,0.16670773488045812,0.7780442493743358,1202]
["Medium","Q96A83","Collagen alpha-1(XXVI) chain [OS=Homo sapiens]",2,1,2,1,441,45.4,7.31,3.96,"other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","COL26A1","ENSG00000160963","","Collagen degradation; Collagen chain trimerization","Protein digestion and absorption",112.4,102.8,101.9,96.3,83.8,80.8,1.2154082023763897,0.2814409332863874,0.03223809394546186,1.4916306434624451,0.18359958973462157,0.7361282935933223,1371]
["Medium","Q96AG3","Solute carrier family 25 member 46 [OS=Homo sapiens]",3,1,1,1,418,46.1,7.43,2.43,"cell organization and biogenesis","other membranes;mitochondrion","","SLC25A46","ENSG00000164209","","","",86.1,132.5,88.1,97.6,111.2,97.9,0.9999999999999999,-1.6017132519074588E-16,1,0,1,0,7808]
["Medium","Q96AN5-1","Transmembrane protein 143 [OS=Homo sapiens]",3,1,1,1,459,51.7,9.67,0,"","other membranes;mitochondrion","","TMEM143","ENSG00000161558","","","",28.1,19.9,19.6,17.9,22.6,21.1,1.0974025974025972,0.13409289558728266,0.555246477126206,0.2555141882400967,0.7330680577276659,0.13485570377156017,5914]
["Medium","Q96AY2","crossover junction endonuclease EME1 [OS=Homo sapiens]",4,1,1,1,570,63.2,7.05,0,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EME1","ENSG00000154920","","Fanconi Anemia Pathway; Resolution of D-loop Structures through Holliday Junction Intermediates","Homologous recombination; Fanconi anemia pathway",10.7,18.7,15.7,17.3,22.3,18.2,0.7802768166089965,-0.3579420592452979,0.20444552256057952,0.6894223962298516,0.4475219064067858,0.34918570090957013,3567]
["High","Q96B01","RAD51-associated protein 1 [OS=Homo sapiens]",13,4,8,4,352,38.4,9.11,14.53,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity","RAD51AP1","ENSG00000111247","","Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function","",460.4,356.4,437.6,793.7,739.3,709.5,0.5593756967670012,-0.8381105205787776,0.001191344605436685,2.9239625973817724,0.03908411209768755,1.4079997497796493,238]
["High","Q96BD8","Spindle and kinetochore-associated protein 1 [OS=Homo sapiens]",13,3,3,3,255,29.5,7.12,7.08,"cell cycle OR cell proliferation;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity","SKA1","ENSG00000154839; ENSG00000262634","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",143.9,111.1,196.9,201.7,169.8,174.6,0.8275041201245192,-0.2731615998032605,0.30787743451794153,0.5116221409879104,0.55097570678801,0.258867549316095,4363]
["High","Q96BN8","Ubiquitin thioesterase otulin [OS=Homo sapiens]",33,12,29,12,352,40.2,5.47,26.38,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","OTULIN","ENSG00000154124","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TNFR1 signaling","",1193.2,858.1,1167.4,1230,1167.7,1127.1,0.9131581933726738,-0.131063283939033,0.41282997606911925,0.3842287756038246,0.6380396779785596,0.1951523128284823,5052]
["High","Q96BR6-1","Zinc finger protein 669 [OS=Homo sapiens]",11,4,7,2,464,52.6,8.72,18.07,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF669","ENSG00000188295","","Generic Transcription Pathway","Herpes simplex virus 1 infection",234.3,235.1,231.5,141.4,125.3,170.4,1.6035232212308395,0.6812452461475066,2.6682180839569043E-3,2.5737786767088804,0.05645920541879541,1.2482652382093054,369]
["High","Q96BY7","autophagy-related protein 2 homolog B [OS=Homo sapiens]",2,4,6,4,2078,232.6,5.76,9.7,"cell organization and biogenesis;other metabolic processes;transport","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","ATG2B","ENSG00000066739","Alzheimer's disease and miRNA effects; Alzheimer's disease","","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",286.8,297.8,285.9,337.8,309,310.5,0.9093283192311712,-0.13712681146200445,0.045864624542834666,1.338522157364986,0.2141812131761083,0.669218625809348,1672]
["High","Q96C36","Pyrroline-5-carboxylate reductase 2 [OS=Homo sapiens]",25,7,29,6,320,33.6,7.77,64.53,"other metabolic processes;stress response","mitochondrion","other molecular function","PYCR2","ENSG00000143811","Metabolic reprogramming in colon cancer","Glutamate and glutamine metabolism","Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids",1315.4,1148.7,1307.6,1252.2,1351.1,1367.5,0.949858970484537,-0.07421476848198548,0.3660754237021724,0.4364294262913705,0.6001085257750497,0.2217702031443256,4763]
["High","Q96C92-4","Isoform 4 of Serologically defined colon cancer antigen 3 [OS=Homo sapiens]",15,4,5,4,362,40,4.88,9.17,"","","","ENTR1","","","","",107,83,116.5,101.7,104.3,105.1,0.9852137576342013,-0.021491320956237944,0.8857939514789714,0.05266728956071465,0.9367843929497236,0.028360353324544185,7383]
["Medium","Q96CN4","EVI5-like protein [OS=Homo sapiens]",1,1,1,1,794,91.3,5.34,1.95,"transport;other biological processes","","enzyme regulator activity;other molecular function","EVI5L","ENSG00000142459","","","",34.4,26,41.6,30.2,27.2,29.6,1.1724137931034482,0.22948184612276717,0.3381710673932664,0.4708635517026595,0.5791708037303409,0.23719333924598635,4559]
["High","Q96CS7-1","Pleckstrin homology domain-containing family B member 2 [OS=Homo sapiens]",14,3,5,3,222,24.7,5.39,7.1,"other biological processes","other membranes;other cytoplasmic organelle","other molecular function","PLEKHB2","ENSG00000115762","","","",402.7,379.7,399.5,413.4,427.2,403.3,0.950156765013265,-0.07376253360277803,0.10728147792206101,0.9694752522241809,0.3265706743140165,0.4860228170133806,2565]
["High","Q96CW6","Probable RNA polymerase II nuclear localization protein SLC7A6OS [OS=Homo sapiens]",42,7,10,7,309,35,4.6,22.52,"transport;developmental processes;other biological processes","nucleus;other cell component","","SLC7A6OS","ENSG00000103061","","","",335.7,382.2,331.6,312.9,349.2,337.2,1.0502351646152308,0.07071240678400954,0.4375661749074334,0.35895625755860183,0.653128788697618,0.18500117292740245,5231]
["High","Q96D71","RalBP1-associated Eps domain-containing protein 1 [OS=Homo sapiens]",12,8,9,8,796,86.6,5.69,18.76,"transport","plasma membrane;other membranes;cytosol","other molecular function","REPS1","ENSG00000135597","","Cargo recognition for clathrin-mediated endocytosis","",427.8,372.4,415.2,461.1,468.4,414.2,0.9045173773907866,-0.14477987503179401,0.14758139982994498,0.8309683746284338,0.37867747941906355,0.42173052232796543,3043]
["High","Q96DE0","U8 snoRNA-decapping enzyme [OS=Homo sapiens]",25,5,13,4,195,21.3,6.89,32.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT16","ENSG00000198585","","Phosphate bond hydrolysis by NUDT proteins","Purine metabolism; Metabolic pathways; RNA degradation",485.1,491.9,501.9,520.1,482,515.3,0.9746276525635956,-0.03707693899943445,0.377314593839472,0.42329639675665276,0.6085668970664321,0.215691674738907,4841]
["High","Q96DM3","Uncharacterized protein C18orf8 [OS=Homo sapiens]",6,3,4,3,657,74.9,7.83,7.57,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle","","RMC1","ENSG00000141452","","","",70.4,67.6,80.8,81.5,78.9,68,0.9579684763572679,-0.06194991257028631,0.6083701284166229,0.21583211839010497,0.7688821564708629,0.11414021769690143,6178]
["High","Q96DU9-1","Polyadenylate-binding protein 5 [OS=Homo sapiens]",5,2,14,1,382,43.3,9.51,32.73,"","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity","PABPC5","ENSANAG00000005063; ENSCCAG00000032154; ENSG00000174740; ENSGGOG00000007622; ENSNLEG00000035086; ENSPPYG00000020526; ENSPTRG00000022078","","","mRNA surveillance pathway; RNA degradation",80.9,77.6,84.5,78.3,70,79.9,1.064855390008764,0.09065752220446135,0.24880117402669305,0.6041475746560122,0.4970930314228299,0.30356232504411235,3908]
["High","Q96DZ1","Endoplasmic reticulum lectin 1 [OS=Homo sapiens]",10,4,8,4,483,54.8,6.28,15.24,"protein metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi","other molecular function","ERLEC1","ENSG00000068912","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis","Protein processing in endoplasmic reticulum",154.8,157.4,159.3,147.6,168.4,161.7,0.9870211429767639,-0.018847105908806228,0.7581214938174361,0.12026119032258999,0.8611307279206489,0.06493091346516111,6874]
["High","Q96E52-1","Metalloendopeptidase OMA1, mitochondrial [OS=Homo sapiens]",6,3,4,3,524,60.1,9.25,7.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion","other molecular function","OMA1","ENSG00000162600","","Regulation of Apoptosis","Spinocerebellar ataxia",135.6,97.4,150.9,181.1,184.7,213.5,0.6626963576730537,-0.593580104824857,0.026259966173914,1.580705837671214,0.1683397503168477,0.7738133213094353,1218]
["High","Q96ED9-1","Protein Hook homolog 2 [OS=Homo sapiens]",13,8,8,8,719,83.2,5.47,19.23,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","HOOK2","ENSG00000095066","","","",293.3,303.6,284.5,311.8,295.8,306.8,0.9639107611548556,-0.053028506937042176,0.2046188267143655,0.6890544099102585,0.44739955166221385,0.349304455444405,3571]
["High","Q96EK5","KIF1-binding protein [OS=Homo sapiens]",16,8,19,8,621,71.8,5.49,37.08,"transport;developmental processes;other biological processes","cytoskeleton;mitochondrion","cytoskeletal activity","KIFBP","ENSG00000198954","","","",799.6,756,784.3,766.6,773.7,827.3,0.9883003885791516,-0.016978487038234985,0.7089239184542255,0.1494003706962845,0.8331243159678797,0.07929018981700599,6644]
["High","Q96EP0-1","E3 ubiquitin-protein ligase RNF31 [OS=Homo sapiens]",18,12,18,12,1072,119.6,6.57,29.82,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RNF31","ENSG00000092098; ENSG00000285152","","Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway","Necroptosis; NOD-like receptor signaling pathway; Shigellosis",561.6,585.2,577.1,507.3,481,486.9,1.1685873101952278,0.22476552811301517,1.4199913838850975E-3,2.8477142907877253,0.04280808002075228,1.3684742502103417,259]
["High","Q96ES7","SAGA-associated factor 29 [OS=Homo sapiens]",29,5,6,5,293,33.2,8.1,10.71,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SGF29","ENSG00000176476","","HATs acetylate histones","",114.2,122.4,130,107.8,98.7,110.1,1.1579279848389132,0.2115455304027043,0.043920538006394,1.3573323486176854,0.20884991519727425,0.6801656967424718,1642]
["High","Q96EX3","Wd repeat-containing protein 34 [OS=Homo sapiens]",8,3,3,3,536,57.8,6.64,3.04,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","DYNC2I2","ENSG00000119333","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 3q29 copy number variation syndrome","Intraflagellar transport","",73.8,66.2,73.8,73.5,76,73.3,0.9596050269299821,-0.05948737961954114,0.3253432003340548,0.48765826558068026,0.5663945837699665,0.24688090830215573,4485]
["High","Q96F44-1","E3 ubiquitin-protein ligase TRIM11 [OS=Homo sapiens]",17,6,10,6,468,52.7,5.69,23.99,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM11","ENSG00000154370; ENSPPAG00000018913; ENSPTRG00000002071","","Antigen processing: Ubiquitination & Proteasome degradation","",493.2,421.4,469.7,412.1,380.6,375,1.1854928491907168,0.24548696061139694,0.04002539729158144,1.397664348585797,0.2004607453833662,0.6979706591160032,1559]
["High","Q96F46","Interleukin-17 receptor A [OS=Homo sapiens]",4,2,2,2,866,96.1,5.21,2.5,"stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","IL17RA","ENSG00000177663","IL-17 signaling pathway","Interleukin-17 signaling","Cytokine-cytokine receptor interaction; IL-17 signaling pathway; Alcoholic liver disease",15.1,16.9,13.5,14.6,8.2,13.1,1.267409470752089,0.34188270126300724,0.2139271061154468,0.6697341836821807,0.4562531670443618,0.34079410790507647,3661]
["High","Q96FL9","Polypeptide N-acetylgalactosaminyltransferase 14 [OS=Homo sapiens]",8,3,5,3,552,64.3,7.72,6.62,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT14","ENSG00000158089","","O-linked glycosylation of mucins","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways",110.9,81,124.1,127.1,128,119.5,0.8435664709022956,-0.2454263411785804,0.20825780321601525,0.6813987170272182,0.45043682202511,0.3463661142742407,3610]
["High","Q96FW1","Ubiquitin thioesterase otub1 [OS=Homo sapiens]",50,10,66,10,271,31.3,4.94,168.33,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","OTUB1","ENSG00000167770","","Ub-specific processing proteases; Ovarian tumor domain proteases","",2005,1787.2,2463.3,2256.9,2628.6,2393,0.859449062306794,-0.2185159580753165,0.20731176115023958,0.6833760589396174,0.4495113110416747,0.34725937565226733,3601]
["High","Q96G21","U3 small nucleolar ribonucleoprotein protein IMP4 [OS=Homo sapiens]",34,8,17,8,291,33.7,9.47,36.47,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","IMP4","ENSG00000136718","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",401.7,360.6,459.6,414.3,441.9,444.2,0.9396339587819132,-0.08982924096578483,0.43624205917229586,0.36027246533715584,0.6526495493422659,0.18531995753398087,5219]
["High","Q96G97-4","Isoform 3 of Seipin [OS=Homo sapiens]",15,6,13,6,462,51.1,5.27,25.3,"","","","BSCL2","","","","",1028.9,734.1,1106.8,1091.8,1123.7,1127.9,0.858347789675181,-0.2203657702694994,0.23858907413169808,0.6223494481466424,0.48601708604756033,0.31334846274235906,3833]
["High","Q96GM5","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [OS=Homo sapiens]",57,22,71,21,515,58.2,9.25,144.54,"cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SMARCD1","ENSG00000066117","Tumor suppressor activity of SMARCB1; Thermogenesis","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Thermogenesis; Hepatocellular carcinoma",2156.4,1891.4,2064.4,2191.5,2277.6,2230.2,{"$f":"AVERAGE(T5506:V5506)/AVERAGE(W5506:Y5506)","v":0.912363978326094},{"$f":"LOG(Z5506,2)","v":-0.1323186071546655},{"$f":"TTEST(T5506:V5506,W5506:Y5506,2,2)","v":0.0744314285169359},{"$f":"-LOG10(AB5506)","v":1.1282436457794696},{"$f":"AB5506*7808/AF5506","v":0.273616098804254},{"$f":"-LOG10(AD5506)","v":0.5628583535302656},2124]
["High","Q96GQ5-1","RUS1 family protein C16orf58 [OS=Homo sapiens]",5,2,5,2,468,51,6.93,16.07,"","other membranes","","C16orf58; RUSF1","ENSG00000140688","","","",173.9,167.2,192.1,164.1,151.3,149,1.1481481481481484,0.19930880822340696,0.059629001240193526,1.224542464836808,0.24363330281707538,0.6132633472331854,1911]
["Medium","Q96GX2","Ataxin-7-like protein 3B [OS=Homo sapiens]",10,1,1,1,97,10.8,4.36,2.57,"other biological processes","other cell component","","ATXN7L3B","ENSG00000253719","","","",109.3,107.6,105.1,126.8,125.6,107.1,0.8956884561891516,-0.1589310823246808,0.12646337903629035,0.8980352182431114,0.35315667507702253,0.45203258065811974,2796]
["High","Q96H22","Centromere protein N [OS=Homo sapiens]",9,2,3,2,339,39.5,9.13,6.1,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","","CENPN","ENSG00000166451","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere","",107.7,52,93.6,97.5,97.4,87.5,0.8969546742209631,-0.15689301155867943,0.5997429803069336,0.2220348265311273,0.7639140603974777,0.1169554963909069,6130]
["High","Q96HB5-1","Coiled-coil domain-containing protein 120 [OS=Homo sapiens]",1,1,1,1,630,67.5,9.38,2.12,"cell organization and biogenesis;other biological processes","cytoskeleton;other cytoplasmic organelle;other cell component","","CCDC120","ENSG00000147144","","","",25,20.3,28.6,26.2,23.8,29,0.9354430379746838,-0.09627828891831401,0.5809415460132973,0.23586756385924182,0.751738745653269,0.12393306503957602,6034]
["High","Q96HP0","Dedicator of cytokinesis protein 6 [OS=Homo sapiens]",14,23,38,20,2047,229.4,6.74,59.64,"signal transduction","cytosol;other cell component","enzyme regulator activity","DOCK6","ENSG00000130158","","CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production","",910.9,749.8,872,783.6,768.7,798.6,1.0773320855842443,0.10746302646279772,0.28631729629849,0.5431524156525258,0.5317710393669387,0.2742753183500949,4204]
["High","Q96I27","Zinc finger protein 625 [OS=Homo sapiens]",21,2,3,1,306,34.7,8.98,9.54,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF625","ENSG00000257591","","Generic Transcription Pathway","",32.2,33.2,40.6,28.9,25.3,26.8,1.308641975308642,0.3880704516785745,0.04295804320563485,1.3669555095326633,0.20679186273094755,0.6844665547491652,1622]
["High","Q96II8-1","Leucine-rich repeat and calponin homology domain-containing protein 3 [OS=Homo sapiens]",19,11,15,11,777,86,6.71,30.21,"cell organization and biogenesis","cytosol;other cell component","","LRCH3","ENSG00000186001","","","",500.5,563.9,504.3,566.5,479.8,549.4,0.9830795262267343,-0.024619966773003606,0.8016672528547883,0.09600585644868065,0.8892481759184809,0.050977016993293406,7039]
["High","Q96IY1","Kinetochore-associated protein NSL1 homolog [OS=Homo sapiens]",22,5,8,5,281,32.1,6.79,9.22,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","","NSL1","ENSG00000117697","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",269.2,407.2,280.3,263.6,235.8,254.9,1.2683282513588758,0.34292817238687384,0.2083548849269402,0.6811963129559475,0.4503972706283359,0.3464042499387802,3612]
["High","Q96JA1","Leucine-rich repeats and immunoglobulin-like domains protein 1 [OS=Homo sapiens]",2,2,2,2,1093,119,7.09,2.24,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","","LRIG1","ENSG00000144749","","Signaling by EGFR; Negative regulation of MET activity","",68.5,76.9,78.1,90.1,77.5,87.6,0.8757836990595612,-0.19135349769418913,0.09700188931709322,1.0132198068471838,0.31091574375528075,0.5073572861493861,2436]
["High","Q96JC9","ELL-associated factor 1 [OS=Homo sapiens]",18,3,4,3,268,29,5.4,9.02,"other biological processes","non-structural extracellular;nucleus;other cell component","other molecular function","EAF1","ENSG00000144597","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",107.3,151.7,84.4,87,66.3,84.5,1.4440706476030276,0.5301413242564782,0.16591791225865057,0.7801067256383282,0.4023251735762558,0.3954227926755237,3220]
["High","Q96JJ7-1","Protein disulfide-isomerase TMX3 [OS=Homo sapiens]",24,9,19,9,454,51.8,4.91,47.36,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TMX3","ENSG00000166479; ENSGGOG00000005485","","Platelet degranulation","",664.5,470.4,651.3,617.6,656.6,617.3,0.9443298969072165,-0.08263714897754612,0.6123574481590806,0.21299499542604086,0.7700574899703818,0.11347685061338872,6209]
["High","Q96JM7","Lethal(3)malignant brain tumor-like protein 3 [OS=Homo sapiens]",11,7,9,6,780,88.3,6.46,13.67,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","other molecular function","L3MBTL3","ENSG00000198945","","","",304.3,345.9,319.9,390.7,390.6,411,0.8136375073387571,-0.29754190831194205,0.00597236782710201,2.2238534527284273,0.08181096139300438,1.0871885037422835,570]
["High","Q96JP5-1","E3 ubiquitin-protein ligase ZFP91 [OS=Homo sapiens]",13,5,6,5,570,63.4,7.36,12.7,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","other molecular function","ZFP91","ENSG00000186660","","","",210.9,325.1,221.4,217.4,242.3,225.8,1.1048869438366156,0.1438987552178311,0.5541794371935969,0.2563495927346437,0.7324023435354781,0.13525027471592016,5908]
["High","Q96K31-1","Uncharacterized protein C8orf76 [OS=Homo sapiens]",4,2,2,2,380,43.2,5.43,4.94,"","","","C8orf76","ENSG00000189376","","","",132,121.3,135.7,137.8,158.5,147.4,0.8767185034933512,-0.18981439794666985,0.06880991719341009,1.162348964787915,0.2625942489961613,0.580714789505421,2046]
["High","Q96KM6","zinc finger protein 512B [OS=Homo sapiens]",7,5,7,5,892,97.2,9.83,9.47,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512B","ENSG00000196700","","RHOV GTPase cycle","",172.9,157.9,165.2,183.5,179.3,185.1,0.9052746851615259,-0.14357248303174194,0.02065604841815033,1.6849527570823573,0.1522969084503473,0.8173089125312069,1059]
["High","Q96KR1","Zinc finger RNA-binding protein [OS=Homo sapiens]",34,26,83,26,1074,116.9,9.04,188.67,"","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZFR","ENSG00000056097","Exercise-induced circadian regulation","","",3170.1,3169.5,3000.3,3220.7,3190.7,3241.6,0.9675644877240238,-0.047570275470964124,0.14844751965283595,0.8284270544511346,0.37965222189628006,0.42061405409116104,3053]
["High","Q96L73-1","Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [OS=Homo sapiens]",4,8,9,8,2696,296.5,8.03,12.95,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD1","ENSG00000165671","Histone modifications; Pathways affected in adenoid cystic carcinoma","PKMTs methylate histone lysines","Lysine degradation; Metabolic pathways",337.8,267.1,309.4,401.4,397.5,405.9,0.7588811420982737,-0.39805415013353945,0.00943561996005055,2.025229559581351,0.10570060351230229,0.9759225330207252,697]
["High","Q96LR4","Protein FAM19A4 [OS=Homo sapiens]",8,1,1,1,140,15.7,8.9,4.32,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","TAFA4","ENSG00000163377","","","",75,73.3,84.6,70.6,71.9,70.8,1.0918893577121425,0.12682667387029456,0.1387722054187923,0.8576975096881793,0.3682982256661897,0.4338003734210552,2942]
["High","Q96LR5","Ubiquitin-conjugating enzyme E2 E2 [OS=Homo sapiens]",34,6,26,3,201,22.2,7.71,57.57,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","UBE2E2","ENSG00000182247","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",873.4,803.6,855,968.6,1052.3,1051.1,0.82421875,-0.27890081129281485,0.006568988848539587,2.1825014753862884,0.08577034269129949,1.066662854716064,598]
["High","Q96ME7","Zinc finger protein 512 [OS=Homo sapiens]",20,13,35,13,567,64.6,9.76,77.31,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512","ENSG00000243943","","","",894.5,918,879.2,1019.9,1016.9,1040.7,0.8746385052802599,-0.19324123154249523,6.8580617148139317E-4,3.163798611043392,0.0322576782344983,1.491366894424812,166]
["High","Q96MR9","Zinc finger protein 560 [OS=Homo sapiens]",2,2,4,1,790,91.1,8.69,5.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF560","ENSG00000198028","","Generic Transcription Pathway","Herpes simplex virus 1 infection",76,119.4,62.9,68.8,67.4,59.9,1.31718510963794,0.3974581079258515,0.29679559159179664,0.5275425540721728,0.5411910273584185,0.2666494123719569,4282]
["High","Q96MW5","Conserved oligomeric Golgi complex subunit 8 [OS=Homo sapiens]",11,6,10,6,612,68.4,5.2,24.18,"transport","other membranes;ER/Golgi","","COG8","ENSG00000213380","","COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",769.4,685.5,727.4,832,825.4,839.6,0.8739687625150181,-0.19434637920044004,0.012946757887467145,1.88783897350295,0.12194003086289924,0.913853699394588,829]
["High","Q96N21-1","AP-4 complex accessory subunit tepsin [OS=Homo sapiens]",4,1,3,1,525,55.1,7.03,2.75,"","other membranes;cytosol;ER/Golgi;nucleus;other cell component","","TEPSIN","ENSG00000167302","","","",31.3,28.6,31.6,35.5,37.2,30.9,0.8832046332046333,-0.179180354515149,0.12848734605428364,0.8911396412774439,0.3547486555841042,0.45007924174367037,2828]
["High","Q96N67","Dedicator of cytokinesis protein 7 [OS=Homo sapiens]",22,37,86,34,2140,242.4,6.8,150.9,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other cell component","enzyme regulator activity;other molecular function","DOCK7","ENSG00000116641","","CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production; MET activates RAP1 and RAC1","",2885.3,2558,2775.8,2905.6,2914.1,2922.7,0.9401422950219621,-0.08904896279276761,0.14437880688535776,0.8404965514217391,0.37427281678647856,0.42681171429176656,3012]
["High","Q96NT0","Coiled-coil domain-containing protein 115 [OS=Homo sapiens]",7,1,1,1,180,19.7,6.95,3.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","CCDC115","ENSG00000136710","","RHOA GTPase cycle","",38.4,32.8,38.3,41.2,36,40.1,0.9335038363171353,-0.0992721435399731,0.3456929564252482,0.4613094692189792,0.584362546821463,0.23331762680689053,4619]
["High","Q96P70","Importin-9 [OS=Homo sapiens]",29,23,79,23,1041,115.9,4.81,153.34,"transport","cytosol;nucleus;other cell component","other molecular function","IPO9","ENSG00000198700","","","Nucleocytoplasmic transport",2846.5,2293.3,2917.2,2852.7,3128.2,3065.9,0.8905911482513154,-0.16716482224577098,0.19825367881932296,0.702778745114478,0.4396378086399527,0.3569049655260269,3521]
["High","Q96PK6-1","RNA-binding protein 14 [OS=Homo sapiens]",46,28,138,28,669,69.4,9.67,261.35,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RBM14","ENSCATG00000036313; ENSG00000239306; ENSGGOG00000014455; ENSMFAG00000003827; ENSMLEG00000024601; ENSMMUG00000020363; ENSPANG00000004924; ENSPPYG00000003015; ENSRBIG00000043267; ENSRROG00000044302","Ciliary landscape","RUNX2 regulates bone development","",5192.1,5100.6,5215.8,4797.6,4783.3,4859.1,1.0739958448753462,0.10298841176901607,1.0718711260560149E-3,2.9698574278962946,0.03856760254490951,1.4137773570861887,217]
["High","Q96PV7-1","Protein FAM193B [OS=Homo sapiens]",8,6,7,6,902,96.5,7.9,7.56,"","nucleus;other cell component","","FAM193B","ENSG00000146067","","","",283.3,237.8,289.9,291.9,254.3,242.4,1.0284047679431905,0.04040820399681888,0.7530254374716437,0.12319035292682326,0.8583390679968751,0.06634111976061344,6850]
["High","Q96Q05","Trafficking protein particle complex subunit 9 [OS=Homo sapiens]",5,5,5,5,1148,128.4,6.62,2.54,"developmental processes;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC9","ENSG00000167632","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",132.3,90.4,128,128.1,128.5,113.9,0.9465587044534415,-0.0792361119403834,0.6651262513617937,0.17709591098921232,0.8052885363053008,0.09404848326791876,6449]
["High","Q96QC0","Serine/threonine-protein phosphatase 1 regulatory subunit 10 [OS=Homo sapiens]",27,22,38,22,940,99,9.17,64.22,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","PPP1R10","ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104","","","",2443.3,2967,2397,2230.5,1991,2143.6,{"$f":"AVERAGE(T5698:V5698)/AVERAGE(W5698:Y5698)","v":1.2265793153289029},{"$f":"LOG(Z5698,2)","v":0.29464052711355276},{"$f":"TTEST(T5698:V5698,W5698:Y5698,2,2)","v":0.06997324885075076},{"$f":"-LOG10(AB5698)","v":1.1550679613715844},{"$f":"AB5698*7808/AF5698","v":0.26534780331552305},{"$f":"-LOG10(AD5698)","v":0.5761845033309804},2059]
["High","Q96QU8","Exportin-6 [OS=Homo sapiens]",6,6,11,6,1125,128.8,6.35,18.38,"transport","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","XPO6","ENSG00000169180","","","Nucleocytoplasmic transport",419.2,388.7,392.5,416.2,380.9,703.9,0.7997335109926716,-0.3224087529097623,0.3846520689774525,0.4149319272244809,0.6146875469864816,0.21134558520326344,4886]
["High","Q96RL1","BRCA1-A complex subunit RAP80 [OS=Homo sapiens]",13,8,8,8,719,79.7,5.45,16.69,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","UIMC1","ENSG00000087206","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","Homologous recombination",493.1,414.8,442.8,590,531.6,583.3,0.7922458795237258,-0.3359798437271816,0.015944108122280386,1.797399769202794,0.13605638931012595,0.8662810586106071,915]
["High","Q96RQ1","Endoplasmic reticulum-Golgi intermediate compartment protein 2 [OS=Homo sapiens]",13,4,9,4,377,42.5,6.77,16.2,"transport","other membranes;ER/Golgi;nucleus;other cell component","","ERGIC2","ENSG00000087502","","","",388.3,387.2,417.1,408.2,435.1,410.7,0.9510366826156299,-0.07242710626523122,0.19097826241550303,0.7190160623347175,0.4314694076794698,0.36504999148293776,3456]
["High","Q96RS6","NudC domain-containing protein 1 [OS=Homo sapiens]",29,12,33,12,583,66.7,5.11,51.84,"other biological processes","cytosol;nucleus","","NUDCD1","ENSG00000120526","","","",768.1,558.5,878.7,813.7,963.3,862.5,0.8354991475658269,-0.2592897385376814,0.2353442249539667,0.6282964542573063,0.48166912409975676,0.3172511918895702,3815]
["High","Q96RW7-1","Hemicentin-1 [OS=Homo sapiens]",1,3,3,3,5635,613,6.49,4.34,"cell adhesion;cell cycle OR cell proliferation;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","HMCN1","ENSG00000143341","","","",90.9,69.2,76.3,86,75.9,89.4,0.9407083167528851,-0.0881806357031228,0.547361091186269,0.2617260773746971,0.7272069763454805,0.13834196343046043,5877]
["High","Q96S55-1","ATPase WRNIP1 [OS=Homo sapiens]",12,7,15,7,665,72.1,6.1,31.84,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","WRNIP1","ENSG00000124535; ENSPTRG00000017666","","","",503.7,592.5,462.8,514.3,494.3,502.7,1.0315622311916892,0.04483085750503762,0.7023765876881304,0.15342997319437116,0.8294247423879192,0.08122301343514565,6612]
["High","Q96S99","Pleckstrin homology domain-containing family F member 1 [OS=Homo sapiens]",7,2,2,2,279,31.2,8.24,1.73,"cell organization and biogenesis;other biological processes","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PLEKHF1","ENSG00000166289","","","",75.3,75.3,74.1,84.5,80.6,83.3,0.9045893719806762,-0.14466504904057434,0.002936773711305198,2.532129516098114,0.05909878643781182,1.2284214370336857,388]
["High","Q96SB8","structural maintenance of chromosomes protein 6 [OS=Homo sapiens]",26,27,50,27,1091,126.2,6.99,113.81,"cell organization and biogenesis;DNA metabolism;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC6","ENSG00000163029","","SUMOylation of DNA damage response and repair proteins","",2827.9,1929.4,2747.2,2683.5,2764.6,2607.1,0.9316342238553976,-0.10216445654129234,0.5618662661313782,0.25036704171322494,0.7381880878266535,0.131832967312799,5943]
["High","Q96SQ9","Cytochrome P450 2S1 [OS=Homo sapiens]",24,13,55,13,504,55.8,8.62,158.41,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","CYP2S1","ENSG00000167600","Vitamin D receptor pathway; Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II","CYP2E1 reactions; Miscellaneous substrates","Retinol metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways",2146.6,2321,2284,2306.2,2330.7,2372.7,0.9631933348550559,-0.05410268597582234,0.20259998064896542,0.6933606004567252,0.44497908548723547,0.3516604008638749,3555]
["High","Q96ST8","Centrosomal protein of 89 kDa [OS=Homo sapiens]",3,3,3,3,783,89.5,6.8,5.59,"cell-cell signaling;cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","","CEP89","ENSG00000121289","","Anchoring of the basal body to the plasma membrane","",244.3,198.4,216.9,197.5,157.1,173.5,1.24900587010036,0.3207802573660288,0.06907875609284186,1.1606554914126082,0.2625934408826238,0.580716126015232,2054]
["High","Q96T21","selenocysteine insertion sequence-binding protein 2 [OS=Homo sapiens]",13,7,9,7,854,95.4,8.12,24.57,"protein metabolism;other metabolic processes;developmental processes;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","SECISBP2","ENSG00000187742","","Selenocysteine synthesis","",358.8,348,366.3,487.6,408.9,432,0.8077531050056455,-0.30801370366148734,0.023705779555029283,1.6251457585107765,0.15997815623653297,0.7959393128038906,1157]
["High","Q96T51","RUN and FYVE domain-containing protein 1 [OS=Homo sapiens]",25,16,34,14,708,79.8,5.74,68.63,"transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RUFY1","ENSG00000176783; ENSG00000284260","","Synthesis of PIPs at the plasma membrane","Endocytosis",1725.2,1497.4,1681,1614.5,1533.5,1519.5,1.0505838243170864,0.07119127681526229,0.35761375524947203,0.44658578485919376,0.5939689855324138,0.22623623138881094,4701]
["High","Q96TC7","Regulator of microtubule dynamics protein 3 [OS=Homo sapiens]",20,10,27,10,470,52.1,5.1,37.86,"other biological processes","non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component","cytoskeletal activity","RMDN3","ENSG00000137824","","","",1213.9,865.4,1177.1,1138.7,1091.4,1129.3,0.969339763052926,-0.044925661903326405,0.7734826417023039,0.11154942817986103,0.8709767041262747,0.059993460841603494,6934]
["High","Q99460","26S proteasome non-ATPase regulatory subunit 1 [OS=Homo sapiens]",51,38,225,38,953,105.8,5.39,535.16,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","PSMD1","ENSG00000173692","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Neutrophil degranulation","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",9179.1,8445.4,9263.9,9072.2,9569.7,9314.8,0.9617873354151243,-0.056210165610831385,0.296574235889205,0.5278665798658029,0.5412930420343414,0.2665675554426767,4278]
["High","Q99487","Platelet-activating factor acetylhydrolase 2, cytoplasmic [OS=Homo sapiens]",12,3,4,3,392,44,6.89,9.99,"other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PAFAH2","ENSG00000158006","","Platelet homeostasis","Ether lipid metabolism; Metabolic pathways",55.6,67.3,70.8,74.9,65.2,67.7,0.9321462945139557,-0.10137170030095809,0.4362059242197573,0.36030844045727545,0.652720555060917,0.185272710562842,5218]
["High","Q99538","Legumain [OS=Homo sapiens]",17,5,17,5,433,49.4,6.55,39.85,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","LGMN","ENSG00000100600","","MHC class II antigen presentation; Trafficking and processing of endosomal TLR; Vitamin D (calciferol) metabolism","Lysosome; Antigen processing and presentation",620.8,627,596.6,502,488.4,525.9,1.2163819824572975,0.2825963518562082,0.001594579498538928,2.7973538239179727,0.045274460816698,1.3441467130896,275]
["High","Q99570","Phosphoinositide 3-kinase regulatory subunit 4 [OS=Homo sapiens]",15,14,32,14,1358,153,7.17,45.52,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIK3R4","ENSG00000196455","Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Ciliopathies; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; DNA damage response (only ATM dependent)","PI3K Cascade; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade","Autophagy; Autophagy; Apelin signaling pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis",886.1,734.4,901.7,805,914.7,861.7,0.9770667079879134,-0.033471031160469275,0.7663782597417685,0.11555682361649307,0.8674806396149215,0.06174020898922961,6898]
["High","Q99611","Selenide, water dikinase 2 [OS=Homo sapiens]",9,2,5,2,448,47.3,5.88,5.26,"other metabolic processes","cytosol;other cell component","kinase activity;other molecular function","SEPHS2","ENSG00000179918","Selenium micronutrient network","Selenocysteine synthesis","Selenocompound metabolism; Metabolic pathways",15.4,22.6,14.9,23.6,12.9,21.7,0.90893470790378,-0.1377514307942583,0.6907982645758508,0.16064876213827667,0.8224691750241298,0.0848803698129877,6558]
["High","Q99614","tetratricopeptide repeat protein 1 [OS=Homo sapiens]",48,11,22,11,292,33.5,4.84,48.22,"other biological processes","cytosol","other molecular function","TTC1","ENSG00000113312","","","",1083.2,1217.3,1086.6,1591.2,1078.1,998.6,0.9234439324954332,-0.11490372519706876,0.6495629442740787,0.18737875833017334,0.7955745049242363,0.09931914277753069,6375]
["High","Q99666","RANBP2-like and GRIP domain-containing protein 5/6 [OS=Homo sapiens]",22,37,115,1,1765,198.8,6.42,239.39,"transport;other biological processes","nucleus;other cell component","","RGPD5; RGPD6","ENSG00000015568; ENSG00000183054","","","",132.2,123.9,162.5,201.9,210.3,204.7,0.6785540606257091,-0.559464334674815,0.005279550956397304,2.277403014104821,0.07705183900476664,1.113216991467414,535]
["High","Q99707","methionine synthase [OS=Homo sapiens]",7,7,10,7,1265,140.4,5.58,16.9,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol","other molecular function","MTR","ENSG00000116984","Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Vitamin B12 disorders; Male infertility","RHOH GTPase cycle; Cobalamin (Cbl, vitamin B12) transport and metabolism; Methylation; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG","Cysteine and methionine metabolism; Selenocompound metabolism; One carbon pool by folate; Metabolic pathways; Biosynthesis of amino acids",233.2,205.4,244.6,244.8,222.1,236.3,0.9715585893060297,-0.041627095522913535,0.6447624170596591,0.1906002853147799,0.7926790981580567,0.10090259339521894,6351]
["High","Q99732","Lipopolysaccharide-induced tumor necrosis factor-alpha factor [OS=Homo sapiens]",4,1,2,1,161,17.1,6.44,4.15,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","LITAF","ENSG00000189067","Intracellular trafficking proteins involved in CMT neuropathy","","Lysosome",239.4,184.3,191.6,237.1,248.2,243.2,0.8446122168840083,-0.2436389797508666,0.09830701798666348,1.0074154774467254,0.3125330604396859,0.5051040352572201,2456]
["High","Q99807-1","5-demethoxyubiquinone hydroxylase, mitochondrial [OS=Homo sapiens]",13,2,2,2,217,24.3,8.59,3.09,"other metabolic processes;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","COQ7","ENSG00000167186","","Ubiquinol biosynthesis","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",40.4,46.1,47.4,44.5,49.4,51.6,0.920274914089347,-0.11986319247133576,0.2674768164104816,0.5727138545449227,0.5133871638478467,0.2895549941369943,4068]
["High","Q99816","tumor susceptibility gene 101 protein [OS=Homo sapiens]",22,10,28,10,390,43.9,6.46,63.9,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TSG101","ENSG00000074319","Ebola virus infection in host; 7q11.23 copy number variation syndrome","HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy","Endocytosis",1485.8,1695.6,1471.6,1607.9,1565.3,1549.7,0.985199771326939,-0.021511801911967634,0.7700241715250533,0.11349564184675744,0.8693390299692909,0.06081082179000701,6916]
["High","Q99933","BAG family molecular chaperone regulator 1 [OS=Homo sapiens]",26,7,13,7,345,38.8,7.81,33.93,"signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","other molecular function","BAG1","ENSG00000107262","Androgen receptor signaling pathway","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",492.4,460.9,477.8,486.5,506.4,456.2,0.9875784969981368,-0.018032670528863683,0.7448004965385878,0.1279600424940918,0.8539504077787509,0.06856734974824158,6810]
["High","Q9BPU6","Dihydropyrimidinase-related protein 5 [OS=Homo sapiens]",35,14,40,14,564,61.4,7.2,122.07,"cell organization and biogenesis;developmental processes;signal transduction","cytosol;other cell component","cytoskeletal activity;other molecular function","DPYSL5","ENSG00000157851","","CRMPs in Sema3A signaling","Axon guidance",1603.1,1580.5,1629.9,1667.9,1640,1677.6,0.9654999498545783,-0.05065191064106185,0.03444923183099922,1.4628204577992499,0.1882292527196934,0.7253128819315847,1429]
["High","Q9BPX5","actin-related protein 2/3 complex subunit 5-like protein [OS=Homo sapiens]",50,6,10,6,153,16.9,6.6,27.79,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity","ARPC5L","ENSG00000136950","Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling pathway","","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",165.8,100.1,169.2,204.1,149.2,162,0.8443625072773142,-0.24406557561249947,0.3928685626195241,0.40575272208438135,0.6213323348051942,0.20667604464527708,4937]
["High","Q9BQ69","O-acetyl-ADP-ribose deacetylase MACROD1 [OS=Homo sapiens]",9,3,4,3,325,35.5,9.51,2.4,"protein metabolism;other metabolic processes;stress response","nucleus","other molecular function","MACROD1","ENSG00000133315","","","",125.6,125.6,127.8,132.5,135.3,125,0.9648676171079429,-0.051597081256239144,0.2193069235845363,0.6589476573006137,0.4621723237106773,0.3351960649573253,3705]
["High","Q9BQB6-1","vitamin K epoxide reductase complex subunit 1 [OS=Homo sapiens]",12,2,4,2,163,18.2,9.36,8.05,"protein metabolism;other metabolic processes;stress response;developmental processes","other membranes;ER/Golgi","other molecular function","VKORC1","ENSG00000167397; ENSPPAG00000037377; ENSPPYG00000007306; ENSPTRG00000008031","","Metabolism of vitamin K","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",363.1,312.8,343.1,341.8,346.4,369.5,0.9634111751914533,-0.05377643616925689,0.488968321164292,0.310719276641615,0.6897677780760239,0.16129709719772126,5535]
["High","Q9BQE5","apolipoprotein L2 [OS=Homo sapiens]",18,6,7,6,337,37.1,6.74,19.08,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","APOL2","ENSG00000128335","","","",524.6,511.4,545.6,578.6,581.7,625.4,0.8857030856246847,-0.17510494993086895,0.019782359373391352,1.7037219128531875,0.1492373545772364,0.8261224579874888,1035]
["High","Q9BQP7","mitochondrial genome maintenance exonuclease 1 [OS=Homo sapiens]",24,7,16,7,344,39.4,7.68,32.53,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","mitochondrion","other molecular function","MGME1","ENSG00000125871","","","",861.4,632.4,933.4,1015.8,1006.9,1030.5,0.7949692126293725,-0.3310291057444528,0.08359110580897904,1.0778399295415086,0.2884133248592613,0.5399846788376019,2263]
["High","Q9BQS8","fyve and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",4,5,5,5,1478,166.9,4.92,8.18,"transport;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FYCO1","ENSG00000163820","","","Salmonella infection",125,133.7,127.9,149.1,130.8,127,0.9501105922831163,-0.07383264286247461,0.4055882799992921,0.39191460299714337,0.6321024531406133,0.19921252420575367,5010]
["High","Q9BRG1","Vacuolar protein-sorting-associated protein 25 [OS=Homo sapiens]",30,3,5,3,176,20.7,6.34,5.87,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS25","ENSG00000131475","","HCMV Late Events; Endosomal Sorting Complex Required For Transport (ESCRT)","Endocytosis",88.5,84.7,116.6,107.6,116.6,113.4,0.8584123222748813,-0.22025730915025618,0.20024128526036059,0.698446375846442,0.44178693283777776,0.3547871338253215,3539]
["High","Q9BRP8","Partner of Y14 and mago [OS=Homo sapiens]",27,4,5,4,204,22.6,9.45,10.55,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity","PYM1","ENSG00000170473","","","Nucleocytoplasmic transport; mRNA surveillance pathway",59.2,83.3,111.7,108.5,88.7,74.9,0.9342153619992649,-0.09817292624471984,0.7573785682011308,0.12068698841994122,0.8607877526221877,0.06510392082085627,6870]
["High","Q9BRS8","La-related protein 6 [OS=Homo sapiens]",15,5,7,5,491,54.7,8.25,9.61,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity","LARP6","ENSG00000166173","","","",199.9,191.6,191.8,197.6,172,175.9,1.0692942254812097,0.09665887760279503,0.20885793815314316,0.6801490136687164,0.450486956104901,0.34631777954324666,3620]
["High","Q9BRT9","DNA replication complex GINS protein SLD5 [OS=Homo sapiens]",34,6,14,6,223,26,4.98,27.89,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes","nucleus;other cell component","","GINS4","ENSG00000147536","","Unwinding of DNA","",546.3,559.2,623.7,643.9,573.8,574.3,0.9649553571428572,-0.05146589604906268,0.5647796592866599,0.24812095292409397,0.7400234233445612,0.13075453369024534,5959]
["High","Q9BS26","Endoplasmic reticulum resident protein 44 [OS=Homo sapiens]",47,18,54,18,406,46.9,5.26,119.58,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","ERP44","ENSG00000023318","","Neutrophil degranulation","",2416,2097.5,2358.6,2296.8,2288.6,2267,1.002874905142724,4.141660799970681E-3,0.9500021528959655,0.022275410511385423,0.9722921496672826,0.012203220748121302,7629]
["High","Q9BSD7","Cancer-related nucleoside-triphosphatase [OS=Homo sapiens]",72,11,29,11,190,20.7,9.54,77.55,"","","other molecular function","NTPCR","ENSG00000135778","","","Purine metabolism; Thiamine metabolism; Metabolic pathways",1277.5,1107.4,1350.3,1405.6,1486.1,1396.2,0.8711024044404021,-0.1990857667703052,0.0760131792999693,1.1191111024424858,0.2774712033539786,0.5567820823553784,2139]
["High","Q9BSJ2-1","Gamma-tubulin complex component 2 [OS=Homo sapiens]",12,10,14,10,902,102.5,6.84,32.13,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","TUBGCP2","ENSG00000130640","15q11.2 copy number variation syndrome","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","",537.7,417.6,537.8,542.8,557.7,571.1,0.8932160804020102,-0.16291887092423335,0.21919653839991385,0.6591663086077714,0.46206440924042314,0.3352974819590327,3704]
["High","Q9BSQ5-1","Cerebral cavernous malformations 2 protein [OS=Homo sapiens]",16,5,5,5,444,48.8,5.54,5.73,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","mitochondrion;other cell component","","CCM2","ENSG00000136280","","","",264,220.6,279.3,193.3,210.8,221.1,1.2218490083173386,0.28906601313465835,0.07535247814144064,1.1229024603306967,0.27583316893031806,0.5593535111214902,2133]
["High","Q9BSY9","Desumoylating isopeptidase 2 [OS=Homo sapiens]",35,3,17,3,194,21.4,4.92,29.12,"protein metabolism;other metabolic processes","other cell component","other molecular function","DESI2","ENSG00000121644","","","",696,309.7,669.8,596.3,566.1,578.6,0.9623779437105111,-0.0553245164466302,0.8697614614007995,0.06059983956763957,0.9281259383104336,0.0323930899423972,7317]
["High","Q9BT67","NEDD4 family-interacting protein 1 [OS=Homo sapiens]",13,2,3,2,221,24.9,4.68,7.2,"protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","NDFIP1","ENSG00000131507","","","",98.4,105.4,96.1,117,128.2,136.6,0.7854897852278679,-0.3483355805351975,0.012509495926574883,1.902760189964261,0.1202883549195772,0.9197764145468008,812]
["High","Q9BTC0","Death-inducer obliterator 1 [OS=Homo sapiens]",27,44,105,44,2240,243.7,7.88,264.18,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytoskeleton;nucleus;other cell component","other molecular function","DIDO1","ENSG00000101191","","","",4420.9,4587.3,4172.8,4512.4,4161.4,4443.5,1.0048561822936124,6.989033803208939E-3,0.9016531525815864,0.04496049448582995,0.944727296746783,0.024693536051399543,7452]
["High","Q9BTE7","DCN1-like protein 5 [OS=Homo sapiens]",30,6,13,6,237,27.5,5.58,16.27,"protein metabolism;other metabolic processes;stress response;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","DCUN1D5","ENSG00000137692","","Neddylation","",508.5,515.8,455.3,563.1,429.2,465.7,1.0148148148148148,0.021216485909695854,0.8787142985694565,0.056152306636988045,0.9320746153009531,0.030549319709992025,7361]
["High","Q9BTV4","Transmembrane protein 43 [OS=Homo sapiens]",30,13,47,13,400,44.8,8.13,116.42,"cell organization and biogenesis","other membranes;ER/Golgi;nucleus","other molecular function","TMEM43","ENSG00000170876","Envelope proteins and their potential roles in EDMD physiopathology","","",2261.8,1980.4,2425.8,2088.6,2123.6,2194.3,1.0408179193007103,0.057717705623119016,0.5500509370134936,0.25959709116107604,0.7295392757264071,0.1369513223146096,5887]
["High","Q9BTZ2","dehydrogenase/reductase sdr family member 4 [OS=Homo sapiens]",11,2,2,2,278,29.5,8.56,7.68,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","DHRS4","ENSG00000157326; ENSG00000284807","","Peroxisomal protein import; RA biosynthesis pathway","Retinol metabolism; Metabolic pathways; Peroxisome",121.6,97.7,117.2,119,124,123.9,0.917143635868084,-0.12478039975086332,0.24945645117240073,0.6030052603263318,0.4971301609887966,0.303529887326414,3918]
["High","Q9BUB7","Transmembrane protein 70, mitochondrial [OS=Homo sapiens]",10,2,2,2,260,29,8.91,5.65,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","TMEM70","ENSG00000175606","","","",79.8,41.5,87.2,94.4,117.3,105.1,0.6581439393939396,-0.6035249517475832,0.0820755370041911,1.0857862670854452,0.28596420924976534,0.5436883189618711,2241]
["High","Q9BUI4","DNA-directed RNA polymerase III subunit RPC3 [OS=Homo sapiens]",37,14,21,14,534,60.6,7.31,42.06,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3C","ENSG00000186141","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",771.3,629,813.1,837,860.4,806.7,0.8839103869653767,-0.17802798187021387,0.16923923677091152,0.771498941902129,0.406715900494699,0.3907088485884764,3249]
["High","Q9BUP0","EF-hand domain-containing protein D1 [OS=Homo sapiens]",18,4,11,2,239,26.9,5.39,17.37,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","EFHD1","ENSG00000115468","","","",168.8,115.2,174.8,190.7,195.4,217.7,0.7598542563762836,-0.39620536549780005,0.0797748878420594,1.0981337977218408,0.2823582612288304,0.5491995011673771,2206]
["High","Q9BV23","Monoacylglycerol lipase ABHD6 [OS=Homo sapiens]",8,2,2,2,337,38.3,8.41,2.68,"other metabolic processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ABHD6","ENSG00000163686","","Arachidonate production from DAG","Retrograde endocannabinoid signaling",38.9,36.6,35.4,42.2,27.6,44.7,0.9685589519650655,-0.046088232822596394,0.8359300924990323,0.07783004039755803,0.9089182791021369,0.04147516246609239,7181]
["High","Q9BV68-2","Isoform 2 of E3 ubiquitin-protein ligase RNF126 [OS=Homo sapiens]",28,4,9,4,311,33.8,5.47,16.16,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","RNF126","ENSG00000070423; ENSPTRG00000010160","","Antigen processing: Ubiquitination & Proteasome degradation","",231.7,289.2,221.8,233.6,205.6,211.7,1.1410354893224768,0.19034366408347397,0.24834755561145394,0.6049401102396519,0.4968223710515584,0.3037988568622652,3903]
["High","Q9BVA0","Katanin p80 WD40 repeat-containing subunit B1 [OS=Homo sapiens]",25,13,22,13,655,72.3,7.56,54.32,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KATNB1","ENSG00000140854","Genes related to primary cilium development (based on CRISPR)","","",992.8,897.9,862.4,948.5,898.3,962.5,0.9799950165521659,-0.029153682000084755,0.6891135298586912,0.16170922318749278,0.8213400154383546,0.08547701796079724,6551]
["High","Q9BVG3","E3 ubiquitin-protein ligase TRIM62 [OS=Homo sapiens]",5,2,4,2,475,54.2,6.62,8.74,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","TRIM62","ENSG00000116525","","Interferon gamma signaling","",106.3,103.3,112.9,98.1,109.6,107.4,1.023484608060933,0.03348940618043918,0.6145205283390978,0.21146360472955222,0.7712869772177585,0.1127840014135864,6221]
["High","Q9BVJ6-1","U3 small nucleolar RNA-associated protein 14 homolog A [OS=Homo sapiens]",26,19,39,19,771,87.9,7.87,77.94,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","UTP14A","ENSG00000156697","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1618.7,1798.6,1502.2,1548.9,1342.5,1494.5,1.1216626006064891,0.16563877431162513,0.16882138017822465,0.7725725535312292,0.4062118140004863,0.39124745000898187,3245]
["High","Q9BVM4","gamma-glutamylaminecyclotransferase [OS=Homo sapiens]",8,1,2,1,153,17.3,6.87,3.18,"other metabolic processes","cytosol","other molecular function","GGACT","ENSG00000134864","","","",76.5,63.7,99.9,86.5,83.7,93.9,0.9091253313138961,-0.1374488979366768,0.5083004594343246,0.29387949775410976,0.7012031779616972,0.1541561242837458,5660]
["High","Q9BVV7","Mitochondrial import inner membrane translocase subunit TIM21 [OS=Homo sapiens]",12,3,4,3,248,28.2,9.7,0,"cell organization and biogenesis;transport","other membranes;mitochondrion","","TIMM21","ENSG00000075336","","Mitochondrial protein import","",66.7,79.6,76.2,73.2,70.2,74.6,1.0206422018348624,0.029477201076833805,0.7312983870135594,0.1359053844752234,0.8464242226210899,0.07241191666977065,6746]
["High","Q9BW71-1","HIRA-interacting protein 3 [OS=Homo sapiens]",11,6,8,6,556,61.9,8.54,20.65,"cell organization and biogenesis","nucleus","","HIRIP3","ENSG00000149929","22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome","","",419.9,398.1,379.2,436.3,388.2,417.6,0.963851541743821,-0.05311714395471017,0.4589652247890133,0.33822021915637623,0.6664683792361197,0.17622045097486008,5377]
["High","Q9BWE0","Replication initiator 1 [OS=Homo sapiens]",22,8,13,8,567,63.5,9.98,42.77,"other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","REPIN1","ENSG00000214022","","","",678.2,655.1,679.7,703.8,648.8,744.6,0.9598512302117111,-0.05911727870765266,0.386095839883857,0.41330487779894615,0.6154831191941926,0.21078385392900603,4898]
["High","Q9BWS9-1","Chitinase domain-containing protein 1 [OS=Homo sapiens]",24,7,12,7,393,44.9,8.63,16.38,"other metabolic processes;stress response;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle","other molecular function","CHID1","ENSG00000177830","","Platelet degranulation","",300.1,261.9,299.9,296.6,264.8,291.3,1.0107892576521638,0.015482236971202134,0.8578983119265132,0.06656418672753887,0.9210050899934298,0.03573796964033775,7273]
["High","Q9BX66-12","Isoform 12 of Sorbin and SH3 domain-containing protein 1 [OS=Homo sapiens]",5,5,7,5,1294,143.7,8.6,11.95,"","","","SORBS1","","","","",343.6,298.6,335.9,284,283.6,287.5,1.143842825400538,0.19388882607294236,0.04243479512982852,1.3722778902046546,0.20541282106243092,0.6873724529349807,1613]
["High","Q9BXA9","sal-like protein 3 [OS=Homo sapiens]",7,7,7,6,1300,135.3,6.99,16.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SALL3","ENSG00000256463; ENSG00000277015","","","",329.1,390.8,294.4,332.5,296.8,307.6,1.0826128722382324,0.11451744687280396,0.4397729524859174,0.3567714847236029,0.6535491459859237,0.18472174851501902,5254]
["High","Q9BXF6","Rab11 family-interacting protein 5 [OS=Homo sapiens]",10,5,7,5,653,70.4,9.23,14.76,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB11FIP5","ENSG00000135631","","","Endocytosis",256.2,282.3,263.9,312.1,284.7,299.2,0.8955357142857141,-0.1591771263327861,0.0479254714045306,1.319433606621428,0.21986021194275848,0.6578533577113618,1702]
["High","Q9BXP5","serrate RNA effector molecule homolog [OS=Homo sapiens]",42,40,132,40,876,100.6,5.96,233.1,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SRRT","ENSG00000087087","","mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes","",6694.2,6914.8,6146.5,6492.4,6135.2,6577.3,1.0286697665699902,0.04077990876534028,0.5274733330835366,0.2777994916462246,0.7148952933025957,0.14575756221411584,5761]
["Medium","Q9BXT8","Ring finger protein 17 [OS=Homo sapiens]",1,1,4,1,1623,184.5,5.4,0,"other biological processes","nucleus;other cell component","other molecular function","RNF17","ENSG00000132972","","","",138.4,62,148.5,147.1,222.9,154.2,0.6655856543304082,-0.5873037561340432,0.18433414185493846,0.7343942185196575,0.42369178086645853,0.37294996073105,3397]
["High","Q9BY11","Protein kinase C and casein kinase substrate in neurons protein 1 [OS=Homo sapiens]",7,3,3,1,444,50.9,5.24,7.13,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","PACSIN1","ENSG00000124507","","Clathrin-mediated endocytosis","",18.5,26.3,22.8,32,22.7,23.5,0.8644501278772377,-0.21014536102516818,0.3975890040975454,0.4005656351544907,0.6255037162993421,0.2037701056931786,4963]
["High","Q9BY77","Polymerase delta-interacting protein 3 [OS=Homo sapiens]",38,14,32,1,421,46.1,9.99,82.46,"other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","POLDIP3","ENSG00000100227","","mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",851,831.9,936.5,1146,1147.9,1095.8,0.7727527509809129,-0.37192120983562543,2.1306738353720996E-3,2.671483027216618,0.05134660897094245,1.2894882327645947,324]
["High","Q9BYD2","39S ribosomal protein L9, mitochondrial [OS=Homo sapiens]",24,6,14,6,267,30.2,10.08,27.86,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL9","ENSG00000143436","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",431.6,463.4,534.6,542.6,530,480.2,0.9206594538897475,-0.1192604836721733,0.3166779090866902,0.49938223121720116,0.5589107400879016,0.2526575448552076,4424]
["High","Q9BYG3","MKI67 FHA domain-interacting nucleolar phosphoprotein [OS=Homo sapiens]",41,10,39,10,293,34.2,9.88,97.72,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","NIFK","ENSG00000155438","","","",1886.8,1585.7,1917.4,1861.9,1969.3,1880.2,{"$f":"AVERAGE(T6146:V6146)/AVERAGE(W6146:Y6146)","v":0.9437090730819063},{"$f":"LOG(Z6146,2)","v":-0.08358592122277796},{"$f":"TTEST(T6146:V6146,W6146:Y6146,2,2)","v":0.38864876880827953},{"$f":"-LOG10(AB6146)","v":0.4104427037480663},{"$f":"AB6146*7808/AF6146","v":0.6169078241217821},{"$f":"-LOG10(AD6146)","v":0.20977972164876227},4919]
["High","Q9BYK8-1","Helicase with zinc finger domain 2 [OS=Homo sapiens]",12,22,34,22,2649,294.5,7.49,66.93,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HELZ2","ENSG00000130589","","PPARA activates gene expression; Heme signaling; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); Transcriptional activation of mitochondrial biogenesis; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RORA activates gene expression","",839.4,745.4,850,626.5,632,662.8,1.2672669546661117,0.341720465761354,0.008187410489768584,2.086853434971101,0.09895867043980357,1.0045461483075495,646]
["High","Q9BYV8","centrosomal protein of 41 kDa [OS=Homo sapiens]",14,3,6,3,373,41.3,8.32,12.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","cytosol;cytoskeleton;other cell component","","CEP41","ENSG00000106477","Joubert syndrome; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",85.8,102.1,94.6,117.1,125.3,105.8,0.8113153360137852,-0.30166533546118857,0.040888507861571555,1.388398737802469,0.20218965762074143,0.6942410631521277,1579]
["High","Q9BZ29-4","Isoform 4 of Dedicator of cytokinesis protein 9 [OS=Homo sapiens]",1,2,2,2,2093,238.7,7.62,3.24,"","","","DOCK9","","","","",55.9,55.3,52.7,50.4,56.4,63.7,0.961290322580645,-0.05695588481207631,0.6088971206304439,0.21545607964438737,0.7691746833655566,0.11397501857757741,6181]
["High","Q9BZE2","tRNA pseudouridine(38/39) synthase [OS=Homo sapiens]",9,4,5,4,481,55.6,7.49,12.14,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PUS3","ENSG00000110060","","tRNA modification in the nucleus and cytosol","",314,235.3,254.8,286,286,257,0.9699638118214716,-0.043997171793378184,0.7616706689393647,0.11823276826515293,0.8636544558638629,0.06365998197517225,6886]
["High","Q9BZH6","WD repeat-containing protein 11 [OS=Homo sapiens]",13,13,29,13,1224,136.6,6.92,55.92,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","WDR11","ENSG00000120008","","RHOH GTPase cycle","",982.5,579.4,1093.2,977.3,1293.3,1011.6,0.8089391261958444,-0.30589695297335723,0.32273428808859944,0.4911548916255012,0.5639904479399697,0.24872825141043725,4468]
["High","Q9BZK7","F-box-like/WD repeat-containing protein TBL1XR1 [OS=Homo sapiens]",27,9,24,6,514,55.6,5.55,55.77,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1XR1","ENSG00000177565","Rett syndrome causing genes","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Heme signaling; HCMV Early Events; HDACs deacetylate histones; Transcriptional activation of mitochondrial biogenesis; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity","Wnt signaling pathway",692,606.7,720.7,777.6,771.4,785.7,0.8649505289758856,-0.20931047501912758,0.03810967776422566,1.4189647233823937,0.19550615241989092,0.7088395711583123,1522]
["High","Q9BZV1","UBX domain-containing protein 6 [OS=Homo sapiens]",18,4,8,4,441,49.7,6.89,16.25,"protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","","UBXN6","ENSG00000167671","","","Protein processing in endoplasmic reticulum",125,105,103.5,130.9,132.6,130.3,0.8468765871000508,-0.23977634982960638,0.044736707098314274,1.349335985855438,0.21093249337176198,0.6758565136456638,1656]
["High","Q9C0B7","Transport and Golgi organization protein 6 homolog [OS=Homo sapiens]",13,9,13,9,1094,120.7,6.11,31.53,"transport","other membranes","","TANGO6","ENSG00000103047","","","",447.2,459.8,425.4,494,436.9,456.8,0.9601498883043886,-0.05866845339338897,0.39844218186356345,0.3996346903767506,0.6259630897365601,0.20345127445144723,4970]
["High","Q9C0C2","182 kDa tankyrase-1-binding protein [OS=Homo sapiens]",59,72,216,72,1729,181.7,4.86,497.34,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TNKS1BP1","ENSG00000149115","Ciliary landscape","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",8989.7,8583.5,8055.7,8873.8,7626.8,7865.2,1.0518390530990158,0.07291396788135872,0.41931499013834894,0.3774596116770405,0.6420889278290309,0.19240481898587866,5099]
["High","Q9C0H2-1","Protein tweety homolog 3 [OS=Homo sapiens]",7,4,14,4,523,57.5,5.39,35.23,"transport","plasma membrane;other membranes","transporter activity","TTYH3","ENSG00000136295","","Stimuli-sensing channels","",473.3,513.3,486.9,393.7,371.3,407.6,1.2566092444141226,0.3295360986148896,0.003155943647795194,2.5008707601109337,0.061297532343245954,1.2125570085367685,402]
["High","Q9C0J8","pre-mRNA 3' end processing protein WDR33 [OS=Homo sapiens]",18,19,34,19,1336,145.8,9.17,53.9,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","WDR33","ENSG00000136709","","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",1701.3,1714.7,1320.8,1813.7,1478,1626,0.9632145108485675,-0.05407096839234754,0.7279427571417603,0.13790277073489945,0.8451713082175262,0.07305525475070969,6725]
["High","Q9GZP9","Derlin-2 [OS=Homo sapiens]",16,2,5,2,239,27.5,7.28,13.02,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","DERL2","ENSG00000072849","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",85.5,80.7,71,72.2,69.8,72.5,1.1058275058275058,0.14512636215909563,0.15689658516184346,0.804386508685256,0.3903915031687934,0.40849964327753846,3138]
["High","Q9GZT4","serine racemase [OS=Homo sapiens]",9,2,4,2,340,36.5,6.54,5.29,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","SRR","ENSG00000167720","Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; D-Amino acid metabolism; Metabolic pathways",67.5,63.8,56,54,52.4,62.1,1.111572700296736,0.15260230817382464,0.23857048845532303,0.6223832802536736,0.4861060474580277,0.313268976001545,3832]
["High","Q9GZU8","Protein FAM192A [OS=Homo sapiens]",27,6,10,6,254,28.9,5.45,17.06,"other biological processes","nucleus","","PSME3IP1","ENSG00000172775","","","",570.5,541.5,548.5,792,523,505.7,0.912011863568957,-0.13287550361052447,0.5969449451997462,0.2240657209619197,0.7622152301095041,0.11792237767558864,6115]
["High","Q9GZY8-1","Mitochondrial fission factor [OS=Homo sapiens]",28,5,10,5,342,38.4,8.95,19.97,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","C2orf33; MFF","ENSG00000168958","","","",82.6,60.9,89.5,111.9,106.1,93.2,0.7487146529562982,-0.41751210544454925,0.06354715348043048,1.1969038983818683,0.25084740868311484,0.6005903809843934,1978]
["High","Q9H019-1","Mitochondrial fission regulator 1-like [OS=Homo sapiens]",25,5,12,5,292,31.9,6.1,27.63,"cell organization and biogenesis;other metabolic processes","mitochondrion","","FAM54B; MTFR1L","ENSG00000117640; ENSPPAG00000030443","","","",303.3,348.5,312.6,317.7,261.9,252.2,1.1594133205097379,0.21339496595616989,0.14712302777658526,0.8323193459428134,0.378496408856533,0.42193823669545444,3035]
["High","Q9H089","Large subunit GTPase 1 homolog [OS=Homo sapiens]",24,14,30,14,658,75.2,6.38,64.71,"transport","cytosol;ER/Golgi;nucleus","other molecular function","LSG1","ENSG00000041802","","","Ribosome biogenesis in eukaryotes",1213.3,1263.6,1190.6,1234,1249.4,1300.5,0.9692380876873066,-0.0450769960845544,0.25850214100996155,0.5875358555682538,0.505607394039524,0.29618658352495186,3992]
["High","Q9H0A8-1","COMM domain-containing protein 4 [OS=Homo sapiens]",37,6,8,6,199,21.8,7.31,22.09,"","plasma membrane;other membranes;cytosol;nucleus;other cell component","","COMMD4","ENSG00000140365; ENSGGOG00000014844","","Neddylation","",231.1,154.4,264,258.3,386.3,323.5,0.6709017663464518,-0.5758265528728548,0.09700722683214805,1.0131959105130117,0.3108052634819089,0.5075116350391006,2437]
["High","Q9H0G5","Nuclear speckle splicing regulatory protein 1 [OS=Homo sapiens]",20,9,13,9,558,66.4,8.84,21.21,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","NSRP1","ENSG00000126653","","","",622.3,670.3,589.2,708.2,700.9,697.8,0.8931605676586456,-0.16300853618006947,0.03418029797821738,1.466224155490898,0.18754727098659266,0.7268892509165469,1423]
["High","Q9H0Q0","Protein FAM49A [OS=Homo sapiens]",18,4,5,4,323,37.3,6.01,9.92,"cell organization and biogenesis","other membranes","other molecular function","CYRIA","ENSG00000197872","","","",100.7,120.8,107.3,91.7,88.4,84,1.2449829609996212,0.31612599751458986,0.0269899925018525,1.5687972360957447,0.17063794449754197,0.7679243890327939,1235]
["High","Q9H0R8-1","Gamma-aminobutyric acid receptor-associated protein-like 1 [OS=Homo sapiens]",13,2,4,1,117,14,8.73,6.43,"cell organization and biogenesis;other metabolic processes;stress response","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","gabarapl1; Gabarapl1; GABARAPL1; gabarapl1.L; GBRL1; LOC101346525; LOC110090845; LOC111142199; LOC113417224; LOC113444478; LOC113982994","ENSACUG00000002920; ENSAMEG00000026339; ENSANAG00000017627; ENSBIXG00000025666; ENSBIXG00005000420; ENSBMUG00000009257; ENSBTAG00000011765; ENSCAFG00000013479; ENSCANG00000037817; ENSCATG00000043779; ENSCCAG00000031173; ENSCGRG00001022681; ENSCGRG00015025519; ENSCHIG00000025179; ENSCJAG00000048408; ENSCPOG00000006718; ENSCPRG00005001116; ENSCSAG00000009078; ENSFCAG00000022695; ENSG00000139112; ENSGAGG00000013450; ENSGALG00000014723; ENSGGOG00000022360; ENSLCNG00005007852; ENSLSDG00000014620; ENSMFAG00000037621; ENSMGAG00000014228; ENSMLEG00000037692; ENSMMUG00000002197; ENSMNEG00000040661; ENSMODG00000018255; ENSMUSG00000030161; ENSNLEG00000029077; ENSNVIG00000010216; ENSOGAG00000000859; ENSPANG00000015789; ENSPCLG00000013759; ENSPPAG00000035460; ENSPSIG00000008179; ENSPTRG00000052409; ENSPTXG00000014934; ENSRBIG00000038034; ENSRFEG00010012750; ENSRNOG00000053362; ENSRROG00000036376; ENSSBOG00000023150; ENSSHBG00005010614; ENSSTOG00000002246; ENSTGUG00000029032; ENSTMTG00000017402; ENSTSYG00000033601; ENSTTRG00000009099; ENSUAMG00000018185; ENSUMAG00000016270; ENSVVUG00000005149; ENSXETG00000016242","Senescence and autophagy in cancer","Macroautophagy; Macroautophagy; Macroautophagy; Macroautophagy; Macroautophagy","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse",96.3,60.8,99.9,114.5,118,103.9,0.7639714625445899,-0.3884093461739035,0.11499063524356434,0.939337526843338,0.33715616972653034,0.47216888862364387,2663]
["High","Q9H0W5","Coiled-coil domain-containing protein 8 [OS=Homo sapiens]",16,5,6,5,538,59.3,8.63,10.27,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","CCDC8","ENSG00000169515","","Neddylation","",235.5,214.5,226.1,241.5,229.5,219.6,0.9790037648421662,-0.03061368704135501,0.6110236558778748,0.21394197565212553,0.7699923668648234,0.11351358008065855,6196]
["High","Q9H0W9","Ester hydrolase C11orf54 [OS=Homo sapiens]",23,6,12,6,315,35.1,6.7,21.13,"","nucleus","other molecular function","C11orf54","ENSG00000182919","","","",381.6,392.9,446.2,460.7,448.2,438.5,0.9059670476473207,-0.14246951819241394,0.11377366980362716,0.9439582333897669,0.3362395207519761,0.47335124200963985,2642]
["High","Q9H1C4","Protein unc-93 homolog B1 [OS=Homo sapiens]",4,2,2,2,597,66.6,6.96,3.23,"stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding","UNC93B1","ENSG00000110057","","Trafficking and processing of endosomal TLR; UNC93B1 deficiency - HSE","",42.2,37.9,40.7,46.4,38.9,42.1,0.9481946624803766,-0.07674482293122165,0.4305412670729474,0.3659852153993404,0.6498484850774353,0.18718788914978762,5173]
["High","Q9H1K0","Rabenosyn-5 [OS=Homo sapiens]",8,6,8,6,784,88.8,5.5,18.35,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RBSN","ENSG00000131381","","Factors involved in megakaryocyte development and platelet production; Toll Like Receptor 9 (TLR9) Cascade","Endocytosis",407.8,281.9,407.7,419.2,415.6,401.2,0.8878640776699029,-0.17158926232186422,0.3362078644716255,0.4733921318939226,0.5769474738009783,0.23886372389239968,4550]
["Low","Q9H211","DNA replication factor Cdt1 [OS=Homo sapiens]",1,1,1,1,546,60.4,9.77,1.75,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CDT1","ENSG00000167513","Retinoblastoma gene in cancer; DNA replication","Orc1 removal from chromatin; Activation of the pre-replicative complex; CDT1 association with the CDC6:ORC:origin complex; G1/S-Specific Transcription","",18,22,16.4,43.1,27.9,33.6,0.5391969407265774,-0.8911157838481479,0.0274640383791813,1.5612356026840026,0.17141423794136498,0.7659531077187871,1251]
["High","Q9H2D6","TRIO and F-actin-binding protein [OS=Homo sapiens]",9,16,28,16,2365,261.2,8.48,54.26,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TRIOBP","ENSG00000100106","","","",983.7,901.8,1121.2,989.8,1023.3,1009.7,0.9946738123594018,-0.007704600833324479,0.93792143909446,0.02783353688386313,0.9663883077922333,0.014848333164202109,7578]
["High","Q9H2H8-1","peptidyl-prolyl cis-trans isomerase-like 3 [OS=Homo sapiens]",37,7,28,7,161,18.1,6.79,42.36,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","CLK1; LOC111141199; PPIL3","ENSAMEG00000005917; ENSCAFG00000011929; ENSECAG00000019985; ENSFCAG00000005373; ENSG00000240344; ENSGGOG00000022268; ENSOCUG00000010661; ENSPPAG00000039183; ENSPPYG00000013062; ENSPTRG00000012793; ENSRFEG00010017851; ENSSSCG00000016096; ENSSSCG00070023158; ENSSSUG00005004462; ENSSTOG00000028255; ENSUMAG00000021460","mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","",1011.5,969.1,949.6,1111.6,1092.1,1148.1,0.874216838713527,-0.19393692804891224,0.004617025348863144,2.3356377410344846,0.07195555673437812,1.142935662243095,501]
["High","Q9H2S1-1","Small conductance calcium-activated potassium channel protein 2 [OS=Homo sapiens]",2,1,1,1,579,63.7,9.52,2.44,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;cytoskeletal activity;other molecular function","KCNN2","ENSG00000080709","Brain-derived neurotrophic factor (BDNF) signaling pathway","Ca2+ activated K+ channels; Acetylcholine inhibits contraction of outer hair cells","Serotonergic synapse; Insulin secretion; GnRH secretion; Bile secretion",20.3,13.2,17,19.9,16.1,22.6,0.8617747440273036,-0.2146172767830911,0.3873707802347781,0.41187314164838806,0.6163829329678312,0.21014939497066815,4907]
["High","Q9H329","Band 4.1-like protein 4B [OS=Homo sapiens]",4,4,14,1,900,99.7,9.04,16,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","EPB41L4B","ENSG00000095203","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","Tight junction",161.4,155.6,166.7,250.9,225.5,226.4,0.6882470119521912,-0.5390016535625136,1.2103936028626905E-3,2.917073380299456,0.0393781385464662,1.4047448173524266,240]
["High","Q9H3C7","Gametogenetin-binding protein 2 [OS=Homo sapiens]",4,2,2,2,697,79,6.38,3.02,"developmental processes;other biological processes","nucleus;other cell component","","GGNBP2","ENSG00000275099; ENSG00000278311","","","",147.9,163.4,142.5,163.5,157.4,148.5,0.9667660843630167,-0.048761232850832746,0.532908027403348,0.27334773776111393,0.7175281734722092,0.14416104185069398,5799]
["High","Q9H3K6-1","bola-like protein 2 [OS=Homo sapiens]",29,2,4,2,86,10.1,6.52,6.85,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","BOLA2; BOLA2B","ENSG00000169627; ENSG00000183336","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",116.5,125.2,129.8,153.3,128.1,119.7,0.9262029419097483,-0.11059975538855027,0.4135130874831529,0.3835107406899852,0.638211145892164,0.19503561543991718,5059]
["High","Q9H3P2-1","Negative elongation factor A [OS=Homo sapiens]",39,14,43,14,528,57.2,9.03,96.4,"developmental processes;other biological processes","cytosol;nucleus","other molecular function","NELFA","ENSG00000185049","Initiation of transcription and translation elongation at the HIV-1 LTR","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1516.8,1614.3,1479.2,1693.2,1513.6,1581.3,0.962866272634239,-0.05459265113238886,0.4203010742922212,0.3764394999336842,0.643094412712848,0.19172526360728023,5103]
["High","Q9H3Z4","DnaJ homolog subfamily C member 5 [OS=Homo sapiens]",20,4,12,4,198,22.1,5.07,29.22,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","DNAJC5","ENSG00000101152","","Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; GABA synthesis, release, reuptake and degradation","Protein processing in endoplasmic reticulum",569.6,926.8,621.7,555.3,576.7,558.6,1.2528688039749203,0.32523534860664294,0.2707374280043405,0.5674517011850386,0.5173562990352155,0.286210258822832,4086]
["High","Q9H479","fructosamine-3-kinase [OS=Homo sapiens]",15,5,7,5,309,35.1,7.55,16.94,"protein metabolism;other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","FN3K","ENSG00000167363","","Gamma carboxylation, hypusine formation and arylsulfatase activation","",239.1,211.4,247.9,281.6,240.7,268.6,0.8830446326969275,-0.1794417354471552,0.13194856041622963,0.8795953436530883,0.35960012556018184,0.4441801652978617,2865]
["High","Q9H4B6","Protein salvador homolog 1 [OS=Homo sapiens]",20,6,10,6,383,44.6,9.09,16.57,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SAV1","ENSG00000151748","Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma","Signaling by Hippo","Hippo signaling pathway; Hippo signaling pathway",309.5,315.6,314.2,288.7,263.1,264.1,1.151244025003064,0.20319366869809347,0.008658969093339032,2.062533810491311,0.10166801606134009,0.9928156511357802,665]
["High","Q9H4G0-1","Band 4.1-like protein 1 [OS=Homo sapiens]",19,13,26,12,881,98.4,5.62,53.71,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","EPB41L1","ENSG00000088367","Splicing factor NOVA regulated synaptic proteins","Trafficking of AMPA receptors; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Neurexins and neuroligins","",672.2,542,637.8,680.7,656.8,679.9,0.9180132844254982,-0.12341306408475282,0.23757036321364033,0.6242077383355209,0.48508090898852085,0.31418581728094797,3824]
["High","Q9H4M3-2","Isoform 2 of F-box only protein 44 [OS=Homo sapiens]",13,2,2,2,224,25.7,7.88,5.88,"","","","FBXO44","","","","",44.6,46.6,56.1,55.3,45.5,55.2,0.9442307692307692,-0.08278859871376149,0.5791661168474951,0.23719685374564725,0.7506854316642166,0.12454201227965606,6024]
["High","Q9H501","ESF1 homolog [OS=Homo sapiens]",25,19,44,19,851,98.7,5.11,98.45,"RNA metabolism OR transcription;other metabolic processes","nucleus","","ESF1","ENSG00000089048","","","",2486.2,2189.9,2404.2,2699.4,2509.8,2605.6,0.9060116701643034,-0.1423984614152641,0.07799297826947364,1.107944495208116,0.2802435224703406,0.5524644168700052,2173]
["High","Q9H5L6","DNA transposase THAP9 [OS=Homo sapiens]",2,2,2,2,903,103.3,9.13,3.01,"DNA metabolism;other metabolic processes","","nucleic acid binding activity;other molecular function","THAP9","ENSG00000168152","","","",50.5,73.9,62.5,43.6,42.7,54,1.3321454027084818,0.41375156012525893,0.11273574896917878,0.9479383455494993,0.3349470045476971,0.475023901778607,2628]
["High","Q9H6A9-1","Pecanex-like protein 3 [OS=Homo sapiens]",3,3,4,3,2034,221.9,6.64,8.04,"","other membranes","","PCNX3","ENSG00000197136","","","",263,214.8,288.6,234.1,237.6,240,1.076858226780947,0.10682832510637542,0.44810659829950855,0.34861866112161727,0.6589107946370175,0.18117337754445093,5310]
["High","Q9H6E4","Coiled-coil domain-containing protein 134 [OS=Homo sapiens]",20,4,12,4,229,26.5,8.85,30.41,"developmental processes","non-structural extracellular;ER/Golgi;nucleus","","CCDC134","ENSG00000100147","","","",400.1,362.4,437.1,411.5,453.8,418.7,0.9342679127725856,-0.09809177514092537,0.3270227618544359,0.48542201797046275,0.5674208276798746,0.24609472708717103,4500]
["High","Q9H6S0","Probable ATP-dependent RNA helicase YTHDC2 [OS=Homo sapiens]",7,6,9,6,1430,160.1,8.4,14.29,"cell cycle OR cell proliferation;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","YTHDC2","ENSG00000047188","","","",286.2,253.8,281.1,291.2,313.2,289.3,0.9187646861362873,-0.12223268888457381,0.12826946324150748,0.8918767226133859,0.3550258663557924,0.4497400041101168,2821]
["High","Q9H6S3","epidermal growth factor receptor kinase substrate 8-like protein 2 [OS=Homo sapiens]",6,4,4,4,715,80.6,6.84,8.54,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","cytoskeletal activity","EPS8L2","ENSG00000177106","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",209.7,214.4,213.7,252.3,211.3,236.5,0.9110127124696471,-0.13445690903900992,0.15933778522495756,0.7976812237668144,0.3943294538942848,0.40414078268833215,3155]
["High","Q9H6Z4-2","Isoform 2 of Ran-binding protein 3 [OS=Homo sapiens]",36,14,47,14,562,59.7,4.81,105.84,"","","","RANBP3","","","","",1656.1,1299.2,1756.1,1847.5,1762.9,1672.9,0.8917532602729353,-0.1652835096553283,0.2659515241511684,0.5751975164223809,0.5115914019641101,0.2910767630810309,4059]
["High","Q9H7H0","Methyltransferase-like protein 17, mitochondrial [OS=Homo sapiens]",5,2,2,2,456,50.7,9.33,5.01,"protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus","other molecular function","METTL17","ENSG00000165792","","","",52.5,54.2,59.2,64.9,67.5,66.1,0.8357682619647355,-0.25882512107445693,0.007168814278348468,2.144552670685692,0.09161064138354312,1.0380540762696109,611]
["High","Q9H7L9","Sin3 histone deacetylase corepressor complex component SDS3 [OS=Homo sapiens]",16,5,8,5,328,38.1,5.66,18.91,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","SUDS3","ENSG00000111707","","Ub-specific processing proteases; NoRC negatively regulates rRNA expression; HDACs deacetylate histones; Potential therapeutics for SARS","",175.9,172.6,184.4,268.5,218.9,202.2,0.7727668213457077,-0.37189494132906353,0.06109302601054801,1.2140083632108256,0.24651904242395806,0.6081495279071205,1935]
["Medium","Q9H816","5' exonuclease Apollo [OS=Homo sapiens]",2,1,1,1,532,60,8.41,0,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DCLRE1B","ENSG00000118655","","Fanconi Anemia Pathway","",75.4,86.7,68.8,80.2,80.1,84.7,0.9424489795918368,-0.08551357611581756,0.4364914133161876,0.36002429534003194,0.6527724487977002,0.18523818389211216,5221]
["High","Q9H8E8-1","Cysteine-rich protein 2-binding protein [OS=Homo sapiens]",9,6,6,6,782,88.8,6.57,14.23,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","KAT14","ENSG00000149474","","HATs acetylate histones","",233.1,226.8,246.4,241.2,283.6,247.6,0.9144225789746245,-0.129067067786689,0.20088136200874587,0.6970603556969791,0.4424489914144676,0.3541367905574291,3545]
["High","Q9H8G2-1","Caspase activity and apoptosis inhibitor 1 [OS=Homo sapiens]",25,6,14,6,361,38.3,4.72,35.38,"other biological processes","","","CAAP1","ENSG00000120159","Acute viral myocarditis","","",344.3,330.5,327.9,362.4,370.2,383.9,0.8980743394536497,-0.1550932237270147,0.009369680568397137,2.028275214848315,0.10587332254420381,0.9752134575638779,691]
["Medium","Q9H8M1","Coenzyme Q-binding protein COQ10 homolog B, mitochondrial [OS=Homo sapiens]",3,1,1,1,238,27.1,9.6,2.33,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ10B","ENSG00000115520","","Respiratory electron transport","",113.1,109.7,117.5,97.4,96.3,95.5,1.1766943291839558,0.2347395990138907,1.84439828288569E-3,2.7341452907757793,0.0489832033767737,1.3099528165293013,294]
["High","Q9H900-1","Protein zwilch homolog [OS=Homo sapiens]",25,11,21,11,591,67.2,6.27,32.56,"cell cycle OR cell proliferation;signal transduction;other biological processes","cytosol;other cell component","","ZWILCH","ENSG00000174442","","RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",799.1,662,770.8,789.5,839.8,784.8,0.9245267387432169,-0.11321304968255684,0.25149626951644954,0.5994684525183382,0.4986497898386079,0.3022043596618023,3938]
["High","Q9H920","RING finger protein 121 [OS=Homo sapiens]",5,1,1,1,327,37.9,7.06,3.13,"protein metabolism;other metabolic processes;stress response;signal transduction","other membranes;ER/Golgi","other molecular function","RNF121","ENSG00000137522","","","",21.2,25.8,19.3,15.6,19.6,23.4,1.1313993174061432,0.17810820569033967,0.43558919294113285,0.3609229037194165,0.6521726593450365,0.18563741182333074,5215]
["High","Q9H9B1","histone-lysine N-methyltransferase EHMT1 [OS=Homo sapiens]",28,24,47,23,1298,141.4,5.76,99.5,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","EHMT1","ENSG00000181090","Histone modifications; MTHFR deficiency","Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; Senescence-Associated Secretory Phenotype (SASP); Regulation of TP53 Activity through Methylation; Transcriptional Regulation by VENTX","Lysine degradation; Metabolic pathways; Longevity regulating pathway",1461.6,1591.6,1493.8,1577.5,1467.8,1601.3,0.9785649722377652,-0.03126045250400199,0.5898030792056078,0.22929296444187874,0.7578052398284328,0.12044239613055968,6077]
["High","Q9H9C1-1","Spermatogenesis-defective protein 39 homolog [OS=Homo sapiens]",31,13,18,13,493,57,7.4,40.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","C14orf133; VIPAS39","ENSG00000151445; ENSPTRG00000006581","","","",731.2,569.3,693.6,748.3,721.8,696.6,0.9203396870817372,-0.11976165282812751,0.3235686144370263,0.49003361078615604,0.5644378332270557,0.24838388398383307,4476]
["High","Q9H9J4-2","Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 42 [OS=Homo sapiens]",10,10,15,10,1316,144.2,8.47,24.71,"","","","USP42","","","","",567.2,559,535.7,544.3,498.7,527.3,1.0583328026491754,0.0817933677473372,0.13452239137080416,0.8712054209447253,0.3630663089606771,0.44001404993407284,2893]
["High","Q9H9Z2","Protein lin-28 homolog A [OS=Homo sapiens]",66,13,106,11,209,22.7,8.07,240.43,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","LIN28A","ENSG00000131914","Cardiac progenitor differentiation; CCL18 signaling pathway","Transcriptional regulation of pluripotent stem cells","",3982.2,4700.4,4016.4,4075.2,4508.2,4277.4,0.9874191341129632,-0.018265493131806594,0.8488042811867464,0.07119243861297044,0.9165348952435508,0.03785099548821246,7231]
["Medium","Q9HAB3","Solute carrier family 52, riboflavin transporter, member 2 [OS=Homo sapiens]",2,1,1,1,445,45.7,7.15,1.63,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC52A2","ENSG00000185803; ENSG00000285112","","Vitamin B2 (riboflavin) metabolism","",48.3,53.9,44.9,47.8,38.5,40.9,1.1564465408805031,0.20969857597047475,0.15816475016789902,0.8008903003159844,0.39254620766400367,0.4061092139446171,3146]
["High","Q9HAS0","Protein Njmu-R1 [OS=Homo sapiens]",26,6,7,6,396,44.6,5.03,15.59,"cell organization and biogenesis;transport","ER/Golgi;other cell component","","C17orf75","ENSG00000108666","","","",190.5,140.8,212.1,216.6,208.5,210.5,0.8549402139710509,-0.22610455912654429,0.22161444829985252,0.654401928905932,0.46490209895895984,0.33263849304204474,3722]
["High","Q9HAV7","GrpE protein homolog 1, mitochondrial [OS=Homo sapiens]",41,10,16,10,217,24.3,8.12,27.2,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","GRPEL1","ENSG00000109519","","Mitochondrial protein import","",666.3,993.6,871.4,1081.8,757.8,729.9,0.985133294415256,-0.02160915186007806,0.9355266394842134,0.02894384128393731,0.9659603281000712,0.015040709651818746,7562]
["High","Q9HB09-1","Bcl-2-like protein 12 [OS=Homo sapiens]",17,5,8,5,334,36.8,9.22,16.21,"other biological processes","nucleus","","BCL2L12","ENSG00000126453","Regulation of apoptosis by parathyroid hormone-related protein","","",406.6,428,414.4,297,290.4,283.3,1.4344780062019065,0.5205258484922953,6.9516155233196065E-5,4.157914255650033,0.01206182533468433,1.9185869647667408,45]
["High","Q9HBE1-1","POZ-, AT hook-, and zinc finger-containing protein 1 [OS=Homo sapiens]",5,3,8,2,687,74,8.35,21.19,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PATZ1; ZNF278","ENSANAG00000029603; ENSCCAG00000028772; ENSCJAG00000010978; ENSG00000100105; ENSSBOG00000003894","Androgen receptor signaling pathway","","",118.1,129.7,108.9,135.7,139.9,127.1,0.8857710454432578,-0.17499425647894243,0.09691695753523512,1.013600227906368,0.3107710901170907,0.5075593887983858,2435]
["High","Q9HBL8","NmrA-like family domain-containing protein 1 [OS=Homo sapiens]",10,3,7,3,299,33.3,7.52,12.91,"","cytosol;nucleus;other cell component","other molecular function","NMRAL1","ENSG00000153406; ENSG00000274684","","Urea cycle","",302.4,247.4,287.3,316.3,321.8,302.9,0.8895855472901167,-0.16879474547505668,0.1164709748354717,0.9337822895678701,0.3392037939259093,0.4695392988921143,2681]
["High","Q9HC07","Transmembrane protein 165 [OS=Homo sapiens]",22,4,12,4,324,34.9,7.02,39.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","TMEM165","ENSG00000134851","IL-18 signaling pathway","","",356.2,414,395.2,402.2,407.6,429.2,0.9405972558514932,-0.08835097168064195,0.2643762653098439,0.5777775367342418,0.5098172090736629,0.2925855088440199,4049]
["Low","Q9HC96","Calpain-10 [OS=Homo sapiens]",1,1,1,1,672,74.9,7.74,1.79,"cell organization and biogenesis;protein metabolism;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","CAPN10","ENSG00000142330","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",46.6,59,48.5,54.7,54,55.1,0.9407814407814408,-0.08806849512622335,0.4503624927599834,0.3464377857092248,0.6602385173619885,0.1802991431535118,5326]
["High","Q9HCE3","Zinc finger protein 532 [OS=Homo sapiens]",16,15,26,14,1301,141.6,8.65,48.84,"","nucleus","nucleic acid binding activity;other molecular function","ZNF532","ENSG00000074657","","","",776.7,717.6,764.7,983,960.3,959,0.7783482065947697,-0.361512382423691,4.0018303198975451E-4,3.3977413296664336,0.026257387510722718,1.580748486400329,119]
["High","Q9HCJ3","Ribonucleoprotein PTB-binding 2 [OS=Homo sapiens]",3,2,3,2,691,74.3,7.47,2.09,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RAVER2","ENSG00000162437","","","",102.1,91.2,128.3,130.8,201,199.4,0.6054216867469879,-0.7239877401679962,0.05262416424913535,1.2788147883509724,0.23044838724467123,0.6374263268676916,1783]
["High","Q9HCP0-1","Casein kinase I isoform gamma-1 [OS=Homo sapiens]",11,4,5,2,422,48.5,9.01,8.29,"cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK1G1","ENSG00000169118; ENSMFAG00000002355; ENSMMUG00000021124; ENSMNEG00000044820; ENSPPYG00000006548; ENSRROG00000038647","Wnt signaling pathway; Hedgehog signaling pathway","","Hedgehog signaling pathway",31.2,40.7,35.6,29.5,36.8,32.2,{"$f":"AVERAGE(T6594:V6594)/AVERAGE(W6594:Y6594)","v":1.0913705583756346},{"$f":"LOG(Z6594,2)","v":0.1261410301330841},{"$f":"TTEST(T6594:V6594,W6594:Y6594,2,2)","v":0.43665697741615284},{"$f":"-LOG10(AB6594)","v":0.35985959578462734},{"$f":"AB6594*7808/AF6594","v":0.6528949980209348},{"$f":"-LOG10(AD6594)","v":0.18515665861291758},5222]
["High","Q9HD20","manganese-transporting ATPase 13A1 [OS=Homo sapiens]",16,17,38,17,1204,132.9,8.13,79.63,"transport;other biological processes","other membranes;ER/Golgi","transporter activity;other molecular function","ATP13A1","ENSG00000105726","","Ion transport by P-type ATPases","",1403.3,1495.2,1485.6,1321.7,1324.2,1410.3,1.080839209111977,0.11215191671680744,0.05687716478295164,1.2450620604816662,0.2391474973749523,0.6213341595628112,1857]
["High","Q9HD42-1","Charged multivesicular body protein 1a [OS=Homo sapiens]",16,5,10,5,196,21.7,8.06,18.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CHMP1A","ENSG00000131165; ENSPPAG00000031215; ENSPPYG00000007667","","HCMV Late Events","Endocytosis; Necroptosis",530.1,579.9,524.5,603.8,538.7,552.3,0.9644205805994809,-0.052265656709261685,0.490638072639993,0.3092387543442463,0.6905014547896656,0.16083540208685818,5548]
["High","Q9NNW7-1","thioredoxin reductase 2, mitochondrial [OS=Homo sapiens]",19,6,8,5,524,56.5,7.5,22.01,"stress response;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","TXNRD2","ENSG00000184470","Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Oxidative stress response; 22q11.2 copy number variation syndrome","Detoxification of Reactive Oxygen Species","Selenocompound metabolism; Pathways in cancer; Hepatocellular carcinoma",240.5,259.1,253.6,239.6,239.7,254.4,1.026577620280769,0.03784271479234647,0.4287500831809965,0.36779578269251006,0.6482727826253333,0.1882422116282573,5164]
["High","Q9NP73-1","Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 [OS=Homo sapiens]",8,6,6,6,1137,126,6.74,8.65,"protein metabolism","other membranes;ER/Golgi","other molecular function","ALG13","ENSG00000101901","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG14 causes ALG14-CMS","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways",72.4,56.4,79.2,87,131.7,104.5,0.6435643564356435,-0.6358436697233405,0.05879168888028293,1.2306840638651395,0.24211260905973053,0.6159825922085516,1896]
["Medium","Q9NP87","DNA-directed DNA/RNA polymerase mu [OS=Homo sapiens]",2,1,1,1,494,54.8,8.41,2.27,"DNA metabolism;other metabolic processes;stress response","nucleus","nucleic acid binding activity;other molecular function","POLM","ENSG00000122678","Non-homologous end joining; DNA repair pathways, full network","Nonhomologous End-Joining (NHEJ)","Non-homologous end-joining",25.5,16.6,33.5,20.1,34.3,24,0.9642857142857142,-0.05246741989413571,0.8921515946098293,0.049561343932482016,0.9396896871325439,0.027015539395588418,7413]
["Medium","Q9NPE2-2","Neugrin [OS=Homo sapiens]",3,1,1,1,291,32.4,9.1,2.4,"developmental processes;other biological processes","non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus","nucleic acid binding activity","NGRN","ENSG00000182768","","","",38.6,27.3,43.3,35,29.9,27.4,1.1830985915492955,0.24257030327407794,0.3435458104627685,0.46401534330702177,0.583512222774265,0.23395004239869607,4597]
["High","Q9NPH2","Inositol-3-phosphate synthase 1 [OS=Homo sapiens]",24,12,52,12,558,61,5.76,130.48,"other metabolic processes","cytosol;other cell component","other molecular function","ISYNA1","ENSG00000105655","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways",1721.2,2005.7,1687.3,1564.4,1532.6,1571.4,1.1597549481621112,0.21382000154339506,0.0707987485618426,1.149974418828445,0.2664080138654781,0.5744527152179212,2075]
["High","Q9NPJ8","NTF2-related export protein 2 [OS=Homo sapiens]",21,3,6,1,142,16.2,5.48,4.31,"transport","cytosol;nucleus;other cell component","","NXT2","ENSG00000101888","","","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; mRNA surveillance pathway; Amyotrophic lateral sclerosis; Influenza A",128,130.3,136.3,112.9,116.2,101.7,1.1928657799274487,0.2544317215522841,0.013458787337963553,1.8709940690983953,0.12465742768068734,0.9042818390645023,843]
["High","Q9NQ66-1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [OS=Homo sapiens]",4,3,3,3,1216,138.5,6.23,2.5,"cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PLCB1","ENSG00000182621; ENSPPAG00000023075; ENSPTRG00000013241","AMP-activated protein kinase (AMPK) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; S1P receptor signal transduction; Cell-type dependent selectivity of CCK2R signaling; Chemokine signaling pathway; GPR40 pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; Fragile X syndrome; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; Alzheimer's disease","Ca2+ pathway; Synthesis of IP3 and IP4 in the cytosol; G alpha (q) signalling events; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Inositol phosphate metabolism; Metabolic pathways; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Apelin signaling pathway; Gap junction; Platelet activation; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Pathways in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis",10.1,5.4,13,13.1,12.1,12.8,0.75,-0.4150374992788438,0.22932402696786355,0.63955044054743,0.47419544559456533,0.32404262151482605,3776]
["High","Q9NQC3","Reticulon-4 [OS=Homo sapiens]",46,30,150,22,1192,129.9,4.5,322.61,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","RTN4","ENSG00000115310","Alzheimer's disease and miRNA effects; Spinal cord injury; 22q11.2 copy number variation syndrome; Alzheimer's disease","Axonal growth inhibition (RHOA activation)","Alzheimer disease",3207.8,3331.7,3242.4,3013.1,2776.6,2854.9,1.1315618999143975,0.1783155066171095,0.008558526332060147,2.067601008798507,0.10109678305707356,0.9952626636255121,661]
["High","Q9NQG6","Mitochondrial dynamics protein MID51 [OS=Homo sapiens]",8,4,5,4,463,51.3,7.64,8.82,"cell organization and biogenesis;stress response;other biological processes","other membranes;mitochondrion","other molecular function","MIEF1","ENSG00000100335","","","",235.9,217.2,215.1,242.6,213.9,227.6,0.976757783949715,-0.03392724734925516,0.6433809410545915,0.19153180839739795,0.7918534659133434,0.10135517804830996,6344]
["High","Q9NQT5","exosome complex component RRP40 [OS=Homo sapiens]",36,5,15,5,275,29.6,8.1,39.12,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","EXOSC3","ENSG00000107371","","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","RNA degradation",442.4,332.4,450.4,473.8,501,448.6,0.860755936490094,-0.21632386903084744,0.1821054965017052,0.7396769456694677,0.4214225597763231,0.37528221926393884,3374]
["High","Q9NQY0-1","Bridging integrator 3 [OS=Homo sapiens]",16,3,3,3,253,29.6,7.47,8.77,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","other molecular function","BIN3","ENSG00000147439; ENSGGOG00000002428; ENSPPAG00000028325; ENSPTRG00000020066","","","",191.4,343.4,212.6,187.7,189.7,196.4,1.3025444405716278,0.38133259561208016,0.2909593416878878,0.5361676945682783,0.5354255337966127,0.2713009216762588,4243]
["High","Q9NR19-1","Acetyl-coenzyme A synthetase, cytoplasmic [OS=Homo sapiens]",5,4,9,3,701,78.5,6.46,19.43,"other metabolic processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","ACSS2","ENSG00000131069","Fatty acid beta-oxidation; Fatty acid biosynthesis; Lipid metabolism pathway; Ethanol effects on histone modifications; Fluoroacetic acid toxicity; Amino acid conjugation of benzoic acid","Transcriptional activation of mitochondrial biogenesis; Ethanol oxidation","Glycolysis / Gluconeogenesis; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism",356,349.5,336.2,395.1,384.7,408.8,0.8764092209321892,-0.19032343150496026,0.005745939546576155,2.240638947562049,0.0802581323428741,1.095510950789837,559]
["High","Q9NR45","sialic acid synthase [OS=Homo sapiens]",49,13,69,13,359,40.3,6.74,117.51,"other metabolic processes","cytosol;other cell component","other molecular function","NANS","ENSG00000095380","","Sialic acid metabolism","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",1956.6,1933.9,1910.9,1803.6,1802.8,1853.1,1.062624782489239,0.08763226478735249,0.005815549255385259,2.2354092616202945,0.08094083526924795,1.0918323182178205,561]
["High","Q9NRF8","CTP synthase 2 [OS=Homo sapiens]",37,19,50,15,586,65.6,6.9,98.28,"other metabolic processes","cytosol;other cell component","other molecular function","CTPS2","ENSG00000047230","Pyrimidine metabolism","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",1810.7,1453,1860,1878,2064.6,2035,0.8571500267665951,-0.22238035387620356,0.11312648958097025,0.9464356892228808,0.3353423047259741,0.4745116551900104,2634]
["High","Q9NRG9-1","Aladin [OS=Homo sapiens]",37,14,30,14,546,59.5,7.5,74.13,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus","","AAAS","ENSG00000094914","","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; RHOA GTPase cycle; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; Regulation of HSF1-mediated heat shock response; Vpr-mediated nuclear import of PICs; Viral Messenger RNA Synthesis; tRNA processing in the nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Ribonucleoproteins into the Host Nucleus; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)","Nucleocytoplasmic transport",1112,1066.8,1116.3,1093.8,1229.3,1172.7,0.9425882487556497,-0.08530039949593367,0.18942105103321857,0.7225717579645531,0.4293177261153471,0.36722117954956235,3445]
["High","Q9NRN9","Methyltransferase-like protein 5 [OS=Homo sapiens]",16,2,7,2,209,23.7,6.68,4.94,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","METTL5","ENSG00000138382","","","",24,15.6,33,30.6,50.4,42.7,0.5869037995149555,-0.7688040469806191,0.08980995292254702,1.0466755312634526,0.2995455414007891,0.5235371403014414,2341]
["High","Q9NRV9","Heme-binding protein 1 [OS=Homo sapiens]",66,11,41,11,189,21.1,5.8,79.41,"other biological processes","non-structural extracellular;other cell component","other molecular function","HEBP1","ENSG00000013583","","G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands","",1939.4,2027.1,2023.1,1773.3,1827.1,1773.1,1.1146552526286406,0.15659757361716667,0.003694067585113179,2.432495163153166,0.0643823207691154,1.1912333724926747,448]
["High","Q9NRX2","39S ribosomal protein L17, mitochondrial [OS=Homo sapiens]",9,2,3,2,175,20,10.11,7.03,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL17","ENSG00000158042","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",178.4,221.8,258,301.9,240,240.9,0.8408277976494635,-0.2501177295024548,0.24888941455506441,0.6039935738537762,0.49714212045176337,0.30351943962738787,3909]
["High","Q9NS69","Mitochondrial import receptor subunit TOM22 homolog [OS=Homo sapiens]",51,4,34,4,142,15.5,4.34,103.23,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity","TOMM22","ENSG00000100216","","PINK1-PRKN Mediated Mitophagy; Mitochondrial protein import","",1039.4,1255.6,1036.9,991.5,1037.9,1031,1.0887138936086787,0.12262487370316097,0.28798256874973843,0.540633798785586,0.5324574702339469,0.2737150755518583,4223]
["High","Q9NS91","E3 ubiquitin-protein ligase RAD18 [OS=Homo sapiens]",16,6,13,6,495,56.2,7.58,36.28,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD18","ENSG00000070950","SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Recognition of DNA damage by PCNA-containing replication complex; E3 ubiquitin ligases ubiquitinate target proteins","",754.8,734.2,779.2,777.2,848.4,820.3,0.9273478065333826,-0.10881756439492785,0.07256459335873533,1.1392752341175738,0.26928913733127635,0.5697811649406399,2104]
["High","Q9NSG2-1","Uncharacterized protein C1orf112 [OS=Homo sapiens]",3,2,4,2,853,96.5,6,2.5,"","","","C1orf112","ENSG00000000460","","","",86,79,85.8,83.5,83.5,99.5,0.9410881801125704,-0.08759818484449913,0.41853729313591254,0.3782658387900782,0.6415271269739311,0.19278497475903913,5094]
["High","Q9NSV4-3","Protein diaphanous homolog 3 [OS=Homo sapiens]",9,8,12,8,1193,136.8,7.03,20.5,"cell organization and biogenesis","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","DIAPH3","ENSG00000139734","Regulation of actin cytoskeleton","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; RHOC GTPase cycle; RHO GTPases Activate Formins; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","Regulation of actin cytoskeleton",372.3,251.4,390.8,282.5,299.9,297,1.1536274732772345,0.2061774274313741,0.36433522177244754,0.4384988417089499,0.5978834408573498,0.22338347475156195,4758]
["High","Q9NTK5-1","obg-like ATPase 1 [OS=Homo sapiens]",71,23,115,10,396,44.7,7.81,241.2,"other metabolic processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","translation activity;other molecular function","LOC111144733; Ola1; OLA1","ENSCCAG00000017844; ENSFCAG00000036661; ENSG00000138430; ENSLCNG00005010543; ENSMMUG00000007092; ENSMNEG00000040767; ENSMPUG00000013906; ENSNVIG00000008347; ENSPTRG00000012650; ENSRROG00000038551","","Platelet degranulation","",6605.8,5156.2,6546.4,6522.4,6300.6,6383.2,0.9532546781768387,-0.0690663887723585,0.5652233695287581,0.2477798902637345,0.7402321484871759,0.1306320573017111,5962]
["High","Q9NTX7","E3 ubiquitin-protein ligase rnf146 [OS=Homo sapiens]",11,3,3,3,359,38.9,5.33,7.74,"cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RNF146","ENSG00000118518","","Ub-specific processing proteases; Degradation of AXIN; Regulation of PTEN stability and activity","",195.3,171.9,203.8,151.9,167.6,155,1.2033719704952583,0.2670826583417336,0.03945398384103871,1.4039091376300732,0.19926048242615152,0.7005788225537439,1546]
["High","Q9NUI1","Peroxisomal 2,4-dienoyl-CoA reductase [OS=Homo sapiens]",12,3,4,3,292,30.8,9.22,10.7,"other metabolic processes","other membranes;cytosol;other cytoplasmic organelle","other molecular function","DECR2","ENSG00000242612; ENSG00000274296","","Peroxisomal protein import; Beta-oxidation of very long chain fatty acids","Peroxisome",196.6,163.1,203.9,161.7,178.7,183.2,1.0763941940412531,0.10620651436439618,0.399855017936847,0.398097449481384,0.6271731579049621,0.20261253709532304,4978]
["High","Q9NUQ3-1","Gamma-taxilin [OS=Homo sapiens]",35,16,29,16,528,60.5,7.52,53.28,"cell cycle OR cell proliferation;other biological processes","other membranes;cytosol;nucleus","other molecular function","TXLNG","ENSG00000086712","","","",803,783.2,946.5,954.4,869.7,834.6,0.9526084176477225,-0.07004479787032131,0.5386675108082309,0.2686792177011395,0.7211789993811157,0.14195692835242235,5832]
["High","Q9NUQ6","SPATS2-like protein [OS=Homo sapiens]",4,3,4,3,558,61.7,9.64,2.15,"","cytosol;nucleus;other cell component","","SPATS2L","ENSG00000196141","","","",215,197.3,219.9,300.5,317.1,308.9,0.6823529411764707,-0.5514099410101293,3.0328779571673779E-4,3.5181450653224253,0.02344624860352761,1.6299266344464327,101]
["High","Q9NUY8","TBC1 domain family member 23 [OS=Homo sapiens]",14,7,14,7,699,78.3,5.41,30.47,"cell organization and biogenesis;transport;developmental processes","cytosol;ER/Golgi;other cell component","","TBC1D23","ENSG00000036054","","","",237,204.8,238.3,267,301,279.7,0.8022885454759939,-0.3178068952899907,0.019435263884905612,1.7114095583010278,0.14790501014945712,0.8300171144181898,1026]
["High","Q9NVA2-1","Septin-11 [OS=Homo sapiens]",40,17,85,7,429,49.4,6.81,191.24,"cell cycle OR cell proliferation;other biological processes","cytoskeleton;other cell component","other molecular function","Sept11; SEPT11; SEPTIN11","ENSANAG00000029750; ENSBTAG00000021372; ENSCATG00000027299; ENSCCAG00000022420; ENSCHIG00000021075; ENSCSAG00000004591; ENSFCAG00000027412; ENSG00000138758; ENSLCNG00005000771; ENSMFAG00000042066; ENSMMUG00000019901; ENSMNEG00000044831; ENSNLEG00000032040; ENSPCTG00005005661; ENSPPAG00000041700; ENSPTRG00000016192; ENSRBIG00000024343; ENSRROG00000038768; ENSSBOG00000020488; ENSSSUG00005020042; ENSUAMG00000017287","22q11.2 copy number variation syndrome","","Bacterial invasion of epithelial cells; Shigellosis",5154.7,4918.2,5031.2,5311.2,5342.6,5431.1,0.9390235562546239,-0.09076674524531109,0.013290674848557522,1.8764529667198924,0.12472787165569367,0.904036488351981,832]
["High","Q9NVF7-1","F-box only protein 28 [OS=Homo sapiens]",24,8,10,8,368,41.1,9.55,27.6,"protein metabolism;other metabolic processes","other cell component","other molecular function","FBXO28","ENSG00000143756; ENSGGOG00000010974; ENSPPAG00000034613; ENSPTRG00000002021","","","",400,410.5,404.1,396.3,359.6,395.8,1.0546149170791002,0.07671630828196693,0.16955501603228149,0.7706893577412903,0.4069737366062262,0.3904336163645085,3253]
["High","Q9NVI1-3","Fanconi anemia group I protein [OS=Homo sapiens]",30,35,82,35,1328,149.2,6.74,164.89,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","FANCI","ENSG00000140525","Gastric cancer network 2; DNA repair pathways, full network","TP53 Regulates Transcription of DNA Repair Genes; Fanconi Anemia Pathway","Fanconi anemia pathway",3577.3,3385.3,3682.7,3704.2,3794.7,3855.3,0.9375649539377497,-0.09300945188187006,0.07248188761286466,1.1397705050501117,0.2691101181556097,0.5700699730777974,2103]
["High","Q9NVM4","Protein arginine N-methyltransferase 7 [OS=Homo sapiens]",15,7,9,7,692,78.4,5.57,20.75,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","PRMT7","ENSG00000132600","Nitric oxide metabolism in cystic fibrosis","RMTs methylate histone arginines","",263.5,215.1,242.6,224.8,213.2,218.3,1.0988877037939968,0.13604396366917068,0.20772571759154854,0.6825097320798437,0.44978436022041346,0.34699564980759146,3606]
["High","Q9NVN3-1","Isoform 1 of Synembryn-B [OS=Homo sapiens]",12,4,7,4,536,60.8,5.88,11.38,"","","","RIC8B","","","","",254.5,138.2,262,201.6,168.2,171.9,1.2086025475355366,0.2733398881174665,0.4148531516069605,0.3821056062588862,0.6388902184905617,0.19457376093358672,5070]
["High","Q9NVS2","39S ribosomal protein S18a, mitochondrial [OS=Homo sapiens]",17,3,3,3,196,22.2,10.33,4.29,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS18A","ENSG00000096080","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",185.7,209.4,196.7,243.4,199.6,189.6,0.9355042680999051,-0.09618385932347238,0.48933220798297294,0.3103961979148431,0.6900317644809558,0.16113091676814112,5537]
["High","Q9NVX7-1","Kelch repeat and BTB domain-containing protein 4 [OS=Homo sapiens]",3,1,1,1,518,58.1,5.67,3.94,"","","","KBTBD4","ENSG00000123444; ENSG00000284900","","","",15.2,18.5,23.3,24.8,21.8,18.2,0.8796296296296298,-0.1850318938325205,0.43896942885279544,0.35756572427461336,0.6537236888198792,0.1846057773297013,5243]
["High","Q9NVZ3","Adaptin ear-binding coat-associated protein 2 [OS=Homo sapiens]",28,6,14,6,263,28.3,8.38,33.44,"transport","plasma membrane;other membranes","","NECAP2","ENSG00000157191","","Cargo recognition for clathrin-mediated endocytosis","",727,636.3,679.3,630.4,689.2,610,1.0585613598673302,0.08210489807541053,0.3467147372379292,0.4600276981039562,0.5852029114469848,0.2326935218799214,4626]
["High","Q9NW82","WD repeat-containing protein 70 [OS=Homo sapiens]",19,11,15,11,654,73.2,6.33,24.47,"other biological processes","nucleus;other cell component","other molecular function","WDR70","ENSG00000082068","","","",693.6,662.9,664.2,653.7,622.2,608.8,1.0721600254682444,0.10052025161608924,0.052932694937445596,1.2762759944147917,0.23012164926034256,0.6380425220874418,1796]
["High","Q9NWM8","Peptidyl-prolyl cis-trans isomerase FKBP14 [OS=Homo sapiens]",7,1,2,1,211,24.2,6.07,2.62,"protein metabolism;other metabolic processes","ER/Golgi","other molecular function","FKBP14","ENSG00000106080","","XBP1(S) activates chaperone genes","",45.3,38.1,37.6,33.6,32.9,28.1,1.2790697674418605,0.35509495882256176,0.043891424901664255,1.357620319886741,0.20883866278622457,0.6801890962811988,1641]
["High","Q9NWQ9","Uncharacterized protein C14orf119 [OS=Homo sapiens]",14,2,2,2,140,16,4.94,1.73,"","cytosol;mitochondrion","","C14orf119","ENSG00000179933","","","",101,135.9,99.8,91.1,90.4,85.2,1.26246719160105,0.33624589627671997,0.12337069700134674,0.9087879816468085,0.34850882857688686,0.45778621569033395,2764]
["High","Q9NWX5","Ankyrin repeat and SOCS box protein 6 [OS=Homo sapiens]",7,2,2,2,421,47.1,6.01,7.64,"protein metabolism;other metabolic processes;signal transduction","cytosol","","ASB6","ENSG00000148331","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",99.2,96.5,124.2,87.3,91.2,80.4,1.2356122054847432,0.30522602721556263,0.0957091482970164,1.0190465484820275,0.30969624115337924,0.5090640657321779,2413]
["High","Q9NWZ5-1","Uridine-cytidine kinase-like 1 [OS=Homo sapiens]",11,6,9,6,548,61.1,7.36,8.55,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","UCKL1","ENSG00000198276; ENSPPAG00000038781","Pyrimidine metabolism","Pyrimidine salvage","Pyrimidine metabolism; Drug metabolism; Metabolic pathways",321.5,394.1,297.9,292.2,312.6,299.1,1.1212523509237746,0.16511101003864176,0.2841108660142319,0.5465121560701708,0.5300687316222515,0.27566781374081417,4185]
["High","Q9NX24","H/ACA ribonucleoprotein complex subunit 2 [OS=Homo sapiens]",18,2,4,2,153,17.2,8.22,11.53,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","NHP2","ENSG00000145912","","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","Ribosome biogenesis in eukaryotes",67.1,97.2,71.6,100.2,77.5,79.5,0.9171850699844479,-0.12471522408848469,0.5814801992920253,0.2354650693871629,0.7519372964677267,0.12381837341560645,6038]
["High","Q9NX61","Transmembrane protein 161A [OS=Homo sapiens]",3,1,2,1,479,53.6,8.44,7.7,"stress response;other biological processes","other membranes","","TMEM161A","ENSG00000064545","","","",36.1,30.9,49,41.4,53.7,56.6,0.7646671061305208,-0.3870962802320989,0.16984415440877343,0.7699493958160345,0.40691720086643235,0.39049395162254324,3259]
["Medium","Q9NX76","CKLF-like MARVEL transmembrane domain-containing protein 6 [OS=Homo sapiens]",5,1,4,1,183,20.4,5.29,5.8,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","","CMTM6","ENSG00000091317","","Neutrophil degranulation","",62.6,76.1,52,47.5,50.5,49.8,1.2902571041948576,0.3676585741666049,0.11177605271860881,0.9516512312096075,0.33374662318428205,0.47658311975426515,2615]
["High","Q9NXF1","Testis-expressed protein 10 [OS=Homo sapiens]",15,13,34,13,929,105.6,9.36,68.49,"","mitochondrion;nucleus","","TEX10","ENSG00000136891","","Major pathway of rRNA processing in the nucleolus and cytosol","",1101.7,1368.9,1106.9,1151.1,1066.3,1164.5,1.0578373103876522,0.08111776587850995,0.5236545345068786,0.28095513140677697,0.7114485132120599,0.14785652388183912,5747]
["High","Q9NXN4-1","Ganglioside-induced differentiation-associated protein 2 [OS=Homo sapiens]",9,3,3,3,497,56.2,5.74,4.92,"other biological processes","","","GDAP2","ENSG00000196505","","","",35.8,34.9,40.9,31.1,29,30.5,1.2317880794701985,0.3007540717829523,0.023719430476474006,1.6248957429592954,0.15993204936123406,0.7960644976920773,1158]
["High","Q9NXS2","Glutaminyl-peptide cyclotransferase-like protein [OS=Homo sapiens]",2,2,3,2,382,42.9,9.82,6.22,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","QPCTL","ENSG00000011478","","","",218.8,189.1,216.6,178.5,169.9,204.1,1.130316742081448,0.17672710732916344,0.16227710594573766,0.7897427461180931,0.39882267649490705,0.3992201562866051,3177]
["High","Q9NY27","Serine/threonine-protein phosphatase 4 regulatory subunit 2 [OS=Homo sapiens]",60,17,47,17,417,46.9,4.54,107.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP4R2","ENSG00000163605","16p11.2 proximal deletion syndrome","Processing of DNA double-strand break ends","",1588.3,1645.5,1560.9,1770.6,1549,1720.9,0.9512349965281223,-0.07212630117806586,0.31637782143484855,0.49979396880920246,0.5590129055811943,0.25257816571286035,4419]
["High","Q9NYF3","protein FAM53C [OS=Homo sapiens]",3,1,2,1,392,43.1,8.65,4.74,"transport","nucleus","","FAM53C","ENSG00000120709","","","",38.8,32.8,30.2,30.8,23.1,21.3,1.353723404255319,0.43693299439805783,0.0837199190639383,1.0771712001864564,0.28847534335888364,0.5398913010551994,2266]
["Medium","Q9NYG2-1","Palmitoyltransferase ZDHHC3 [OS=Homo sapiens]",3,1,2,1,299,34.1,8.18,0,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","ZDHHC3","ENSCCAG00000029642; ENSG00000163812","","","",39.1,43.8,43.8,38.3,35.5,46.2,1.0558333333333334,0.0783821186449287,0.5651134498022081,0.24786435629196085,0.7402123496151051,0.130643673462803,5961]
["High","Q9NYP3-1","Protein downstream neighbor of son [OS=Homo sapiens]",11,4,5,4,566,62.7,8.66,3.66,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction","nucleus;other cell component","","DONSON","ENSG00000159147","","","",159.4,193.1,153.9,171.4,175.1,189.3,0.9451287793952967,-0.0814171764140378,0.5054932227159099,0.2962846627372998,0.6994313455548156,0.15525490834870573,5643]
["High","Q9NYU1","UDP-glucose:glycoprotein glucosyltransferase 2 [OS=Homo sapiens]",5,7,9,6,1516,174.6,6.89,9.87,"protein metabolism;other metabolic processes;stress response","ER/Golgi;other cell component","other molecular function","UGGT2","ENSG00000102595","","ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",151.8,146.4,152.1,143.7,138.2,155.5,1.0294924554183815,0.04193325729375159,0.4726542449299846,0.3254564373336538,0.6761605614535214,0.16995016400889612,5458]
["High","Q9NYZ3","G2 and S phase-expressed protein 1 [OS=Homo sapiens]",9,5,8,5,720,76.6,9.39,10.13,"cell cycle OR cell proliferation;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","GTSE1","ENSG00000075218","","The role of GTSE1 in G2/M progression after G2 checkpoint; G2/M Checkpoints","p53 signaling pathway",246.9,347.3,217,161,120,127.3,1.9867744305657609,0.99042808477819,0.03150984697093158,1.5015537059926576,0.18183953078273007,0.7403116979316451,1353]
["High","Q9NZ53-1","Podocalyxin-like protein 2 [OS=Homo sapiens]",2,1,2,1,605,65,4.34,2.38,"cell adhesion","plasma membrane;other membranes;ER/Golgi","other molecular function","PODXL2","ENSG00000114631","","Cytosolic sulfonation of small molecules","",20.2,19.6,19.3,19.8,21.4,21.1,0.9486356340288923,-0.07607403284646969,0.12839543926417865,0.8914504025722939,0.35524861437799676,0.4494676073319876,2822]
["High","Q9NZ72","Stathmin-3 [OS=Homo sapiens]",13,3,3,2,180,21,7.49,5.11,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","STMN3","ENSG00000197457","","","",80.4,89.7,103.9,99.4,113.9,93.2,0.8939641109298531,-0.16171118073025498,0.3034372493672641,0.5179311071297892,0.546789301421555,0.26217999150552856,4333]
["High","Q9NZI7","Upstream-binding protein 1 [OS=Homo sapiens]",16,6,15,5,540,60.5,6.35,38.79,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBP1","ENSG00000153560","","","",504.1,373.7,508.7,396.2,476.4,406.4,1.0840500390930414,0.11643135215784163,0.5204782482029867,0.2835974157842025,0.7094787293940155,0.14906062042536622,5728]
["High","Q9NZJ5","Eukaryotic translation initiation factor 2-alpha kinase 3 [OS=Homo sapiens]",14,10,17,10,1116,125.1,5.43,43.91,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","EIF2AK3","ENSG00000172071","Translation factors; Alzheimer's disease and miRNA effects; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; 7q11.23 copy number variation syndrome; Alzheimer's disease","Signaling by ALK fusions and activated point mutants; ALK mutants bind TKIs; PERK regulates gene expression","Mitophagy; Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Hepatitis C; Measles; Herpes simplex virus 1 infection; Lipid and atherosclerosis",616.3,662.8,641.1,552,588.1,584.2,1.1136113205358695,0.15524578224571042,0.020816741146419796,1.681587258154203,0.15261700926877536,0.8163970612703243,1065]
["High","Q9NZM5","ribosome biogenesis protein NOP53 [OS=Homo sapiens]",15,5,9,5,478,54.4,10.32,18.47,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP53","ENSG00000105373","","","",259.8,289.4,261.6,482.2,288,403.3,0.6909245845760547,-0.5333998479436334,0.10205481568347861,0.9911664973132579,0.3182284348468854,0.4972610171930146,2504]
["High","Q9NZV5-1","Selenoprotein N [OS=Homo sapiens]",5,3,7,3,590,65.8,5.48,12.9,"cell organization and biogenesis;stress response;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SELENON","ENSG00000162430","Selenium micronutrient network","","",518.8,483.1,515.3,455.3,475,464.1,1.0880665519219734,0.12176680216855214,0.0322654481399685,1.4912622985294628,0.18348770508148143,0.7363930311075826,1373]
["High","Q9P000-1","COMM domain-containing protein 9 [OS=Homo sapiens]",34,4,5,4,198,21.8,5.88,11.85,"transport;other biological processes","non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component","","COMMD9","ENSG00000110442","","Neddylation; Neutrophil degranulation","",292.5,229.6,277,318.6,346.4,345.2,0.7910314789150663,-0.33819298733086606,0.028476491769832833,1.5455135156970876,0.17425113459157898,0.7588243854235956,1276]
["High","Q9P0J0","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [OS=Homo sapiens]",43,5,31,5,144,16.7,8.43,47.91,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;mitochondrion;nucleus;other cell component","transporter activity;other molecular function","NDUFA13","ENSG00000186010","Nucleotide-binding oligomerization domain (NOD) pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",758.7,746.7,795.1,770.7,876.5,817.1,0.9335308201111877,-0.09923044170467779,0.18255756392030992,0.7386001681878334,0.42196846035813496,0.3747200087641878,3378]
["High","Q9P0N9","TBC1 domain family member 7 [OS=Homo sapiens]",29,6,8,6,293,34,7.94,12.97,"other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","TBC1D7","ENSG00000145979","Fragile X syndrome","TBC/RABGAPs","mTOR signaling pathway",196.7,187.7,192.4,212.3,220.6,209.6,0.8977431906614786,-0.1556252897277804,0.006497695376092094,2.1872406530377213,0.08512417029618635,1.0699471081193226,596]
["High","Q9P0S3","ORM1-like protein 1 [OS=Homo sapiens]",20,2,5,2,153,17.4,9.64,11.03,"other metabolic processes;other biological processes","other membranes;ER/Golgi","","ORMDL1","ENSG00000128699","","Sphingolipid de novo biosynthesis","",178.8,153.8,207.2,156.3,167.4,160.5,1.11482858323007,0.15682189746791472,0.3048538785531352,0.5159082752246129,0.5476988227664242,0.26145819255048325,4346]
["High","Q9P1F3","Costars family protein ABRACL [OS=Homo sapiens]",16,1,3,1,81,9.1,6.29,3.27,"other biological processes","","","ABRACL","ENSG00000146386","","","",19.7,22.8,17,33.6,23.4,25.3,0.7229647630619683,-0.46800276222632,0.09911709275745474,1.003851444907938,0.31357628049035924,0.5036567956105068,2468]
["High","Q9P1U1-1","Actin-related protein 3B [OS=Homo sapiens]",25,8,34,4,418,47.6,5.88,59.14,"","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTR3B","ENSCANG00000039781; ENSCATG00000043872; ENSCCAG00000019061; ENSCJAG00000019650; ENSCSAG00000006554; ENSG00000133627; ENSMFAG00000034566; ENSMMUG00000018920; ENSMNEG00000033219; ENSPANG00000006816; ENSPPYG00000018206; ENSPTRG00000019897; ENSRROG00000045018","","","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",362.4,320.3,370,366.9,355.7,356.8,0.9752640355753198,-0.036135238849315285,0.6046823995270507,0.21847267220689678,0.7672018484737102,0.11509035945970097,6154]
["High","Q9P219","Protein Daple [OS=Homo sapiens]",7,12,13,12,2028,228.1,6.23,29.23,"cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","CCDC88C","ENSG00000015133","Ectoderm differentiation; Ectoderm differentiation","Negative regulation of TCF-dependent signaling by DVL-interacting proteins","",700.4,841.3,743,760.2,734.4,758.8,1.0138901215940357,0.019901311492355765,0.8183783319895785,0.08704587785642397,0.8990992002497016,0.046192388640216096,7107]
["High","Q9P275","Ubiquitin carboxyl-terminal hydrolase 36 [OS=Homo sapiens]",15,14,22,14,1121,122.6,9.67,34.03,"","","","","","","","",1093.4,1067.3,1052.9,1006.6,962.2,923.9,1.1109344211290488,0.15177365641710908,0.015993222928081537,1.796064009121852,0.13602950394603555,0.866366885664459,918]
["High","Q9P2D3-1","HEAT repeat-containing protein 5B [OS=Homo sapiens]",7,9,13,9,2071,224.2,7.17,17.02,"transport;other biological processes","cytosol;other cell component","","HEATR5B","ENSG00000008869","","","",319.7,277.1,321.7,314,337.3,323.9,0.9418580803937654,-0.0864184046215002,0.30386405442269876,0.5173206717173043,0.5469272791453278,0.26207041473684334,4338]
["High","Q9P2E5-1","Chondroitin sulfate glucuronyltransferase [OS=Homo sapiens]",8,6,8,6,772,85.9,7.83,9.18,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHPF2","ENSG00000033100; ENSGGOG00000001088","","Chondroitin sulfate biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",535.5,572.8,562.5,513.3,499.6,500.1,1.1042961004626568,0.14312706105869302,0.011817169590316347,1.9274865317886136,0.11724073718067349,0.9309214594890428,787]
["High","Q9P2J5","Leucine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",48,52,268,52,1176,134.4,7.3,493.34,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","LARS1","ENSG00000133706","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",9165.1,8937.1,9273.5,9479,10019.8,9960.1,0.9292845286144426,-0.10580770584352431,0.024665841514607104,1.607904063298697,0.16279872404569085,0.788349003267992,1183]
["High","Q9P2L0-1","WD repeat-containing protein 35 [OS=Homo sapiens]",7,5,9,5,1181,133.5,6.38,22.32,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","","WDR35","ENSG00000118965","Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",210.4,213.2,244.4,219,213.9,243.4,0.9877273399378974,-0.017815251061503196,0.8550052963714561,0.06803119500542601,0.9200498007260651,0.03618866439882947,7256]
["High","Q9P2R3","Rabankyrin-5 [OS=Homo sapiens]",16,15,25,14,1169,128.3,6.1,57.1,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ANKFY1","ENSG00000185722","","RHOD GTPase cycle","",993.9,810,1042.7,849.8,905.7,827.2,1.1021798892631745,0.1403597086349147,0.30362235463609616,0.5176662560384422,0.5468704371392478,0.26211555319203583,4335]
["Medium","Q9P2Z0","THAP domain-containing protein 10 [OS=Homo sapiens]",4,1,2,1,257,28.3,8.6,5.18,"","","nucleic acid binding activity;other molecular function","THAP10","ENSG00000129028","","","",136.2,94.7,144.9,128.1,125.5,111.5,1.0293070391673513,0.04167339798517086,0.8377369187058304,0.07689234496476409,0.9097426788950103,0.04108143068901132,7190]
["High","Q9UBB6","Neurochondrin [OS=Homo sapiens]",37,21,61,21,729,78.8,5.48,142.15,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","NCDN","ENSG00000020129","Splicing factor NOVA regulated synaptic proteins","","",1755.3,1655.3,1782.3,1543,1578.3,1610.8,1.097377485682889,0.13405988220815473,0.023865735359526186,1.622225179455532,0.15981446113823367,0.7963839252198918,1166]
["High","Q9UBF8-2","Isoform 2 of Phosphatidylinositol 4-kinase beta [OS=Homo sapiens]",5,3,3,3,801,89.8,6.44,4.63,"","","","PI4KB","","","","",79.6,77.3,66.9,70.1,59.8,81.5,1.0586565752128667,0.0822346595937111,0.605545404418896,0.2178532874519103,0.7679224488716486,0.11468263638475659,6157]
["High","Q9UBM7","7-dehydrocholesterol reductase [OS=Homo sapiens]",21,10,65,10,475,54.5,8.7,99.19,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","DHCR7","ENSG00000172893","Vitamin D metabolism; Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol","Steroid biosynthesis; Metabolic pathways",2128.2,2256.5,2233.1,2208.4,2286.8,2263.9,{"$f":"AVERAGE(T7106:V7106)/AVERAGE(W7106:Y7106)","v":0.9790948499060524},{"$f":"LOG(Z7106,2)","v":-0.030479467069926876},{"$f":"TTEST(T7106:V7106,W7106:Y7106,2,2)","v":0.3619221533688123},{"$f":"-LOG10(AB7106)","v":0.44138483277638235},{"$f":"AB7106*7808/AF7106","v":0.5970606747313937},{"$f":"-LOG10(AD7106)","v":0.22398153258574097},4733]
["High","Q9UBP6","tRNA (guanine-N(7)-)-methyltransferase [OS=Homo sapiens]",26,6,13,6,276,31.5,7.64,38.11,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","METTL1","ENSG00000037897","","tRNA modification in the nucleus and cytosol","",601,728.3,659.4,681.9,677.4,688.5,0.9711397597421623,-0.0422491615728764,0.6219991805514087,0.20621018746711672,0.7765541416286216,0.10982825971539574,6254]
["High","Q9UBQ6","Exostosin-like 2 [OS=Homo sapiens]",14,3,5,3,330,37.4,8.95,5.45,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EXTL2","ENSG00000162694","","XBP1(S) activates chaperone genes","Glycosaminoglycan biosynthesis; Metabolic pathways",259.3,215.3,267.7,230.4,290.9,256.2,0.9547266881028937,-0.06684030640139252,0.6491964930176268,0.18762383491359164,0.7953752106514405,0.09942794873482215,6373]
["High","Q9UBU8-2","Isoform 2 of Mortality factor 4-like protein 1 [OS=Homo sapiens]",38,11,34,9,323,37.2,9.19,90.42,"","","","MORF4L1","","","","",1032.6,1147,1095.8,1198.4,1120.3,1180.8,0.9359622803257608,-0.0954777051251441,0.14012706347275664,0.8534779790482927,0.36900914387699285,0.4329628720899387,2965]
["High","Q9UBV8","Peflin [OS=Homo sapiens]",7,2,12,2,284,30.4,6.54,19.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PEF1","ENSG00000162517","","","",336.3,248.6,424.8,445.8,433.2,405.9,0.7858199081640594,-0.3477293770198275,0.15375345018845246,0.8131751299851019,0.3850246757765994,0.41451143617928937,3118]
["High","Q9UDT6-2","Isoform 2 of CAP-Gly domain-containing linker protein 2 [OS=Homo sapiens]",26,25,49,1,1011,111.7,6.83,119.09,"","","","CLIP2","","","","",126.3,74.5,135.3,106.3,118,118.6,0.9801691455234763,-0.02889736162763244,0.9124583139064064,0.0397869673689774,0.9514522589451417,0.02161299844039081,7488]
["High","Q9UDY2","Tight junction protein ZO-2 [OS=Homo sapiens]",33,31,97,1,1190,133.9,7.4,182.97,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","TJP2","ENSG00000119139","1q21.1 copy number variation syndrome","Signaling by Hippo; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Apoptotic cleavage of cell adhesion  proteins","Tight junction; Vibrio cholerae infection",3897.8,3603.7,3885.2,4749.9,4445.8,4686,0.8202669701837672,-0.28583455847929107,3.3690615659746743E-3,2.4724910526820527,0.061895606369718255,1.2083401780737288,425]
["High","Q9UEG4","zinc finger protein 629 [OS=Homo sapiens]",13,7,11,5,869,96.6,7.93,17.83,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF629","ENSG00000102870","","","",210,299.5,229.7,219.9,205.6,224.5,1.1372307692307693,0.18552503861287842,0.34418014057267493,0.46321419237140393,0.5835740581088916,0.23390402224563622,4605]
["High","Q9UG63","ATP-binding cassette sub-family F member 2 [OS=Homo sapiens]",23,15,41,15,623,71.2,7.37,64.83,"transport","","transporter activity;other molecular function","ABCF2","ENSG00000033050","VEGFA-VEGFR2 signaling pathway","","Pathogenic Escherichia coli infection",2569.6,2008.4,2513.6,2501.3,2367.3,2433.1,0.9712258789049125,-0.04212123129380365,0.7208536847825011,0.14215287722238795,0.8410677780606348,0.0751690048541095,6692]
["High","Q9UGN5-1","Poly [ADP-ribose] polymerase 2 [OS=Homo sapiens]",3,2,4,2,583,66.2,8.88,5.13,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP2","ENSG00000129484","NAD+ biosynthetic pathways; Base excision repair; Peroxiredoxin 2 induced ovarian failure; DNA repair pathways, full network","Dual Incision in GG-NER; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; HDR through MMEJ (alt-NHEJ); POLB-Dependent Long Patch Base Excision Repair","Base excision repair; Apoptosis",188.4,124.8,185.6,224.5,232.9,226.5,0.7293463956718818,-0.4553239241963195,0.04189821651209907,1.3778044633210333,0.20484738542671851,0.6885695748008809,1597]
["High","Q9UGU0","Transcription factor 20 [OS=Homo sapiens]",7,12,14,12,1960,211.6,9.04,29.68,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","TCF20","ENSG00000100207; ENSG00000262024; ENSG00000276461; ENSG00000280467; ENSG00000281897; ENSG00000282892; ENSG00000283026; ENSG00000283681","Matrix metalloproteinases","","",867.8,893.7,892.1,933.9,802.7,833.8,{"$f":"AVERAGE(T7170:V7170)/AVERAGE(W7170:Y7170)","v":1.0323685029567384},{"$f":"LOG(Z7170,2)","v":0.045958031316610345},{"$f":"TTEST(T7170:V7170,W7170:Y7170,2,2)","v":0.5307093603321025},{"$f":"-LOG10(AB7170)","v":0.27514325247852583},{"$f":"AB7170*7808/AF7170","v":0.7165448185151402},{"$f":"-LOG10(AD7170)","v":0.1447566401234851},5783]
["High","Q9UGY1","Nucleolar protein 12 [OS=Homo sapiens]",21,3,5,2,213,24.6,10.23,11.14,"","nucleus","nucleic acid binding activity;other molecular function","NOL12","ENSG00000273899","","Major pathway of rRNA processing in the nucleolus and cytosol","",88,43,87.2,88.3,66.4,73.3,0.9570175438596491,-0.06338272272849685,0.8501511904217106,0.0705038327245937,0.9168481346426404,0.03770259426310522,7240]
["High","Q9UHB7-1","AF4/FMR2 family member 4 [OS=Homo sapiens]",12,10,14,10,1163,127.4,9.31,27.56,"other biological processes","nucleus;other cell component","","AFF4","ENSG00000072364","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",376.4,403.1,379.5,391.7,341,365.7,1.0551711580480698,0.07747703574673336,0.29780084404199175,0.5260740756830365,0.541885106101112,0.2660927855570731,4291]
["High","Q9UHD2","Serine/threonine-protein kinase TBK1 [OS=Homo sapiens]",24,14,25,14,729,83.6,6.79,68.53,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;kinase activity;other molecular function","TBK1","ENSG00000183735","TNF-alpha signaling pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Toll-like receptor signaling pathway","Negative regulators of DDX58/IFIH1 signaling; Potential therapeutics for SARS; Interleukin-37 signaling; IRF3-mediated induction of type I IFN; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; TICAM1-dependent activation of IRF3/IRF7; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Regulation of innate immune responses to cytosolic DNA; STAT6-mediated induction of chemokines; IRF3 mediated activation of type 1 IFN","Ras signaling pathway; Mitophagy; Autophagy; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; IL-17 signaling pathway; Alcoholic liver disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Shigellosis; Yersinia infection; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis",1178.4,1098.5,1191.7,1145.1,1165.1,1113.1,1.0132328454999564,0.018965750098156865,0.669246589446852,0.17441383334713592,0.80839687042095,0.09237537645503023,6464]
["High","Q9UHI8","a disintegrin and metalloproteinase with thrombospondin motifs 1 [OS=Homo sapiens]",9,6,8,6,967,105.3,6.83,17.04,"cell organization and biogenesis;protein metabolism;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","other molecular function","ADAMTS1","ENSG00000154734","VEGFA-VEGFR2 signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Malignant pleural mesothelioma","Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins; Degradation of the extracellular matrix","",451.3,595.9,459.4,208.8,225.6,223.5,2.290013679890561,1.1953562165979064,3.8991862729428526E-3,2.4090260170872506,0.06632864143603005,1.1782988979658762,459]
["High","Q9UHL0-1","ATP-dependent RNA helicase DDX25 [OS=Homo sapiens]",8,2,10,1,483,54.7,6.28,20.64,"other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX25","ENSG00000109832","","","",13.6,16.2,24.2,21.5,27.2,24,0.7427785419532325,-0.4289959568687635,0.15759570899815797,0.8024556116167173,0.3912582816717385,0.4075364567393696,3145]
["High","Q9UHQ4","B-cell receptor-associated protein 29 [OS=Homo sapiens]",27,8,13,8,241,28.3,9.54,25.33,"transport;other biological processes","other membranes;ER/Golgi","","BCAP29","ENSG00000075790; ENSG00000283852","","","",929,1084,924.6,875.3,877.5,891.1,1.111085895835697,0.1519703529160309,0.13647496287915095,0.8649470151489995,0.3656817124778348,0.4368967579243354,2914]
["High","Q9UHV7","mediator of RNA polymerase II transcription subunit 13 [OS=Homo sapiens]",0,1,1,1,2174,239.1,5.64,2.62,"other biological processes","nucleus","other molecular function","MED13","ENSG00000108510","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",53.6,70.7,65.8,70,59.8,53.1,1.0393657736468016,0.055703456899835684,0.7513453931046772,0.12416037213542094,0.8574254354518152,0.06680363732582931,6842]
["High","Q9UI10-1","translation initiation factor eIF-2B subunit delta [OS=Homo sapiens]",34,13,32,1,523,57.5,9.38,82.69,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF2B4","ENSG00000115211","Translation factors","Recycling of eIF2:GDP","Herpes simplex virus 1 infection",16,13.8,17.3,16,15.7,18.6,0.9363817097415508,-0.0948313401927438,0.4812564728466024,0.31762341623116885,0.6835820520258816,0.16520934853826402,5497]
["High","Q9UI95","Mitotic spindle assembly checkpoint protein MAD2B [OS=Homo sapiens]",16,3,5,3,211,24.3,6.52,2.43,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD2L2","ENSG00000116670","Cell cycle","Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Bacterial invasion of epithelial cells",114.5,64.5,122.7,143.7,195.3,154.1,0.6118434394646116,-0.7087655563544168,0.05690116923782788,1.2448788093813887,0.23911966060762113,0.6213847143803763,1858]
["High","Q9UIF8-1","Bromodomain adjacent to zinc finger domain protein 2B [OS=Homo sapiens]",1,2,2,2,2168,240.3,6.54,6.12,"cell organization and biogenesis;other biological processes","nucleus","nucleic acid binding activity;other molecular function","BAZ2B","ENSG00000123636","","","",73.6,101.5,88.2,80.9,84.4,87.4,1.0419469726948951,0.05928185710128773,0.6912971901154848,0.16033520837117549,0.8225614843678308,0.08483162976256896,6562]
["High","Q9UIJ7-1","GTP:AMP phosphotransferase AK3, mitochondrial [OS=Homo sapiens]",65,13,42,13,227,25.6,9.16,65.5,"other metabolic processes;stress response","mitochondrion;other cell component","kinase activity;other molecular function","AK3","ENSG00000147853; ENSGGOG00000028122","","Factors involved in megakaryocyte development and platelet production","Purine metabolism; Biosynthesis of cofactors",1964.4,1659.6,1929.2,1848.2,1934.9,1893.2,0.9783133379137817,-0.03163148384657045,0.7011180929707725,0.1542088253913488,0.8291926794783083,0.08134454072700618,6602]
["High","Q9UIW2","Plexin-A1 [OS=Homo sapiens]",10,16,21,13,1896,210.9,6.92,39.52,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","PLXNA1","ENSG00000114554","","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Sema3A PAK dependent Axon repulsion; RHOD GTPase cycle; RND1 GTPase cycle; CRMPs in Sema3A signaling; Other semaphorin interactions","Axon guidance",660.9,662.3,711.1,709.3,633.2,713.2,0.9895899207082746,-0.015097288811400053,0.828381539005898,0.08176958819143612,0.9044893101046079,0.04359656157367034,7151]
["Medium","Q9UJ99","Cadherin-22 [OS=Homo sapiens]",2,1,4,1,828,89,4.81,0,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CDH22","ENSG00000149654","Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Malignant pleural mesothelioma","","",27.3,31.1,39.4,34.4,34.2,25.6,1.0382165605095544,0.05410740533945085,0.8071468853655122,0.0930474247587938,0.8919053044061589,0.049681253198985094,7066]
["High","Q9UJQ4","Sal-like protein 4 [OS=Homo sapiens]",19,14,33,13,1053,112.2,7.47,77.44,"cell cycle OR cell proliferation;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SALL4","ENSG00000101115","Vitamin D receptor pathway; Wnt/beta-catenin signaling pathway in leukemia","Regulation of PTEN gene transcription; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","",1633.1,1583,1514.3,2486.9,2293.8,2439.5,0.6551619068723857,-0.6100766181952963,2.5191185066460734E-4,3.598751401548387,0.021854752555436157,1.6604541063290765,90]
["High","Q9UJU6-2","Isoform 2 of Drebrin-like protein [OS=Homo sapiens]",47,15,51,1,431,48.3,5.05,132.53,"","","","DBNL","","","","",121.1,116.5,90.9,96.5,94.1,123.9,1.0445151033386328,0.06283335344304053,0.7452411827214134,0.12770315359534978,0.8540794297209446,0.068501737876112,6813]
["High","Q9UJX4","Anaphase-promoting complex subunit 5 [OS=Homo sapiens]",21,11,18,11,755,85,6.87,38.35,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ANAPC5","ENSG00000089053","Cell cycle","Separation of Sister Chromatids; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of APC/C activators between G1/S and early anaphase; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; IL-17 signaling pathway; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection",367.5,369.5,410.3,335.2,353.3,360.2,1.0940211690664632,0.1296406542289419,0.10620200061799218,0.9738673020005889,0.32454998858132406,0.488718401812685,2555]
["High","Q9UJZ1","Stomatin-like protein 2, mitochondrial [OS=Homo sapiens]",67,18,146,18,356,38.5,7.39,292.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","signal transduction activity or receptor binding;other molecular function","STOML2","ENSG00000165283","","Processing of SMDT1","",3204,3234.8,3232.8,3096.2,3146.5,3094,1.0358692043227264,0.05084185033371857,0.004891871003554087,2.3105250036356053,0.07474702308366009,1.1264060991116829,511]
["High","Q9UK58","Cyclin-L1 [OS=Homo sapiens]",9,3,4,3,526,59.6,10.7,9.86,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","enzyme regulator activity","CCNL1","ENSG00000163660","","","",154.1,155.7,171.4,203.9,185.9,182.8,0.840377226685295,-0.25089102782327666,0.023838579318117257,1.622719630336458,0.16004439150116898,0.7957595404062711,1163]
["High","Q9UKA9-1","Polypyrimidine tract-binding protein 2 [OS=Homo sapiens]",27,8,38,1,531,57.5,8.66,69.19,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","LOC101350812; PTBP2","ENSANAG00000033752; ENSCSAG00000001494; ENSG00000117569; ENSMMUG00000016130; ENSPANG00000001229; ENSPPYG00000001132","Genes targeted by miRNAs in adipocytes; mRNA processing","","",419,373,421.9,570.5,622.8,588.8,0.6811626732506595,-0.5539287153489186,1.0071004352163097E-3,2.9969272163528484,0.03873615861166969,1.411883449607426,203]
["High","Q9UKF6","Cleavage and polyadenylation specificity factor subunit 3 [OS=Homo sapiens]",21,11,23,11,684,77.4,5.6,59.14,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","CPSF3","ENSG00000119203","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript","mRNA surveillance pathway",528.5,353.3,514.9,503.5,569.5,556.7,0.8570289010247284,-0.2225842386685935,0.26375734525804356,0.5787954370568383,0.5092525597860544,0.2930667793171664,4044]
["High","Q9UKK3","Poly [ADP-ribose] polymerase 4 [OS=Homo sapiens]",3,3,3,3,1724,192.5,5.66,3.75,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP4","ENSG00000102699","NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome","Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein","Base excision repair; Apoptosis",44,32.3,66.7,44.9,54.9,42.5,1.004919184820801,0.007079485139269196,0.9837806386636551,0.007101728843447463,0.9907596061764244,4.031708154319481E-3,7753]
["High","Q9UKM9-2","Isoform 1 of RNA-binding protein Raly [OS=Homo sapiens]",55,14,62,14,290,30.3,9.63,140.27,"","","","RALY","","","","",2761.5,2393.6,2790.1,2984.4,3262.8,3063.6,0.8533316148988271,-0.228821595784283,0.040288114598104295,1.3948230562353185,0.20087458415197848,0.6970750092986078,1566]
["High","Q9UKU7","Isobutyryl-CoA dehydrogenase, mitochondrial [OS=Homo sapiens]",9,4,5,4,415,45,7.85,8.28,"other metabolic processes","mitochondrion","other molecular function","ACAD8","ENSG00000151498","","Branched-chain amino acid catabolism","Valine, leucine and isoleucine degradation; Metabolic pathways",288.3,268.7,262,270.5,325.3,310.2,0.9039735099337748,-0.14564759840522654,0.185278926690632,0.7321739737864554,0.4247380679977847,0.3718788127544023,3406]
["High","Q9UKW4","Guanine nucleotide exchange factor VAV3 [OS=Homo sapiens]",4,4,6,3,847,97.7,7.05,14.63,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;cytosol","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","VAV3","ENSG00000134215","Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mesodermal commitment pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; T-cell receptor (TCR) signaling pathway","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOG GTPase cycle; RAC2 GTPase cycle; FCERI mediated Ca+2 mobilization; FCERI mediated MAPK activation; DAP12 signaling; EPH-ephrin mediated repulsion of cells; GPVI-mediated activation cascade; VEGFR2 mediated vascular permeability","Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Yersinia infection; Proteoglycans in cancer; Lipid and atherosclerosis",152,135.4,147.1,173.4,154,155.4,0.8999585749792877,-0.15206949905325867,0.11296278828561818,0.9470645963727167,0.3353663311536527,0.4744805402038392,2630]
["High","Q9UL15-1","BAG family molecular chaperone regulator 5 [OS=Homo sapiens]",27,9,18,9,447,51.2,6.05,33.98,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","BAG5","ENSG00000166170","","Regulation of HSF1-mediated heat shock response","",534.2,621,479.7,468.1,467.7,497.3,1.1408136208219943,0.19006311215305824,0.18694561556458503,0.7282847158985589,0.42705423239563484,0.36951696962464153,3418]
["High","Q9UL63-1","muskelin [OS=Homo sapiens]",21,11,18,11,735,84.7,6.34,26.5,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","MKLN1","ENSG00000128585","Ciliary landscape","","",625.1,644.1,622.6,647.2,669.9,593.8,0.9900047098225968,-0.014492706239012994,0.8003149025814005,0.09673909607791491,0.8885054399766209,0.051339908832685716,7033]
["High","Q9ULD9","zinc finger protein 608 [OS=Homo sapiens]",2,3,6,2,1512,162.1,8.79,11.89,"other biological processes","nucleus","other molecular function","ZNF608","ENSG00000168916","","","",257.8,151.2,174.1,231.7,146.9,186.2,1.032400849858357,0.04600323415197153,0.8878962809312665,0.051637763106586694,0.9379913626723487,0.027801160726487945,7391]
["High","Q9ULH1-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",3,3,5,3,1129,125.4,7.31,9.77,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ASAP1","ENSG00000153317","EGF/EGFR signaling pathway; CCL18 signaling pathway","VxPx cargo-targeting to cilium","Endocytosis; Fc gamma R-mediated phagocytosis",92.1,43.8,97.8,60.1,55.7,54.6,1.3714788732394363,0.4557323985569868,0.2874636398016667,0.5414170797817568,0.5323804790254776,0.2737778773276117,4216]
["High","Q9ULJ7-1","Ankyrin repeat domain-containing protein 50 [OS=Homo sapiens]",5,5,7,5,1429,155.8,6.6,20.17,"transport","other cytoplasmic organelle","","ANKRD50","ENSG00000151458","","","",248.4,225.1,267.5,250,249.1,231.2,1.014651513076818,0.0209843119584976,0.807500493462338,0.0928572036000732,0.8920435558791646,0.04961393977616424,7068]
["High","Q9ULT8","E3 ubiquitin-protein ligase hectd1 [OS=Homo sapiens]",16,39,61,39,2610,289.2,5.35,119.59,"protein metabolism;other metabolic processes;developmental processes;other biological processes","","other molecular function","HECTD1","ENSG00000092148","","Antigen processing: Ubiquitination & Proteasome degradation","",2593,2992.4,2651.4,3027.1,3051.4,3065.9,0.9007479987752067,-0.15080455352010633,0.07283281395935655,1.1376729103750947,0.269515929570927,0.5694155610141518,2110]
["High","Q9ULV0","unconventional myosin-Vb [OS=Homo sapiens]",3,6,6,2,1848,213.5,7.2,9.72,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5B","ENSG00000167306","","Vasopressin regulates renal water homeostasis via Aquaporins","Pathogenic Escherichia coli infection",77.8,75.7,92.7,82.1,83.1,77.7,1.0135858377933307,0.019468271848592435,0.8539094923850321,0.06858815863276267,0.9191239752608671,0.036625905218542844,7254]
["High","Q9ULZ3","apoptosis-associated speck-like protein containing a CARD [OS=Homo sapiens]",50,10,31,10,195,21.6,6.34,70.96,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PYCARD","ENSG00000103490","Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling","Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; CLEC7A/inflammasome pathway","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Lipid and atherosclerosis",1313.5,1103.7,1319.4,1406.9,1586.6,1556.9,0.8211585794655415,-0.2842672374198448,0.03957303556176475,1.4026006346680238,0.1997325544061145,0.6995511437087559,1547]
["High","Q9UM47","Neurogenic locus notch homolog protein 3 [OS=Homo sapiens]",4,8,13,6,2321,243.5,5.39,17.82,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","NOTCH3","ENSG00000074181","Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; OSX and miRNAs in tooth development; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Neovascularisation processes; Osteoblast differentiation and related diseases; Notch signaling pathway","Pre-NOTCH Transcription and Translation; Pre-NOTCH Processing in Golgi; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Pre-NOTCH Processing in the Endoplasmic Reticulum; Defective LFNG causes SCDO3; Noncanonical activation of NOTCH3","Endocrine resistance; Notch signaling pathway; Apelin signaling pathway; Th1 and Th2 cell differentiation; Thyroid hormone signaling pathway; Human papillomavirus infection; Pathways in cancer; MicroRNAs in cancer; Breast cancer",309.7,324.6,318.5,352.3,331.8,343.6,0.9271188089909506,-0.1091738648187327,0.02733235819218197,1.5633228964570056,0.17182854489899904,0.7649046876389316,1242]
["Medium","Q9UN36-1","Protein NDRG2 [OS=Homo sapiens]",4,2,2,1,371,40.8,5.21,3.96,"cell-cell signaling;signal transduction;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","NDRG2","ENSG00000165795","","","",68.7,71,58.7,69,65.9,64.5,0.9949849548645936,-0.00725338401132098,0.9376334280618323,0.027966917789291206,0.9663465953414448,0.014867079125872816,7576]
["Low","Q9UNA0","A disintegrin and metalloproteinase with thrombospondin motifs 5 [OS=Homo sapiens]",1,1,1,1,930,101.7,8.85,0,"cell organization and biogenesis;protein metabolism;stress response;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi","signal transduction activity or receptor binding;other molecular function","ADAMTS5","ENSG00000154736","Vitamin D receptor pathway; Endochondral ossification; IL-18 signaling pathway; Endochondral ossification with skeletal dysplasias","Degradation of the extracellular matrix; Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins","",351.4,62.3,356,263,408,316.8,0.7792063170682325,-0.3599227214120897,0.5303482566339347,0.27543885442710253,0.7164289252245263,0.14482688818899622,5780]
["High","Q9UNE7-1","E3 ubiquitin-protein ligase CHIP [OS=Homo sapiens]",29,8,13,8,303,34.8,5.87,33.16,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","STUB1","ENSCATG00000030791; ENSCSAG00000012299; ENSG00000103266; ENSGGOG00000043504; ENSMFAG00000031388; ENSMNEG00000033024; ENSPPAG00000028029; ENSPPYG00000006921; ENSPTRG00000007553; ENSRBIG00000029383; ENSRROG00000037882","Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway; Androgen receptor signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Downregulation of TGF-beta receptor signaling","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",387.2,451.8,513,513.9,456.7,471,0.9378468368479468,-0.09257576464399184,0.49858232611093994,0.30226312055453913,0.6946700218190969,0.15822144250964074,5604]
["High","Q9UNL2","Translocon-associated protein subunit gamma [OS=Homo sapiens]",15,4,14,4,185,21.1,9.61,35.32,"transport","other membranes;ER/Golgi","","SSR3","ENSG00000114850","VEGFA-VEGFR2 signaling pathway","SRP-dependent cotranslational protein targeting to membrane","Protein processing in endoplasmic reticulum",504.7,501.1,572.7,554.9,559.8,517.4,0.9671588750689296,-0.04817519438170161,0.542406295385231,0.26567527851562256,0.7235790798509967,0.14051399797116765,5853]
["High","Q9UNN8","Endothelial protein C receptor [OS=Homo sapiens]",5,1,3,1,238,26.7,7.18,4.91,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","PROCR","ENSG00000101000","","Cell surface interactions at the vascular wall; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",19.5,22.4,21.6,37.7,41.4,38.3,0.540885860306644,-0.8866039114505239,2.3478926480494921E-4,3.6293217640792617,0.021567465642318158,1.6662008851349188,85]
["High","Q9UNY4-1","transcription termination factor 2 [OS=Homo sapiens]",27,25,46,25,1162,129.5,8.37,93.56,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","TTF2","ENSG00000116830","Thyroid stimulating hormone (TSH) signaling pathway; Thyroid hormones production and peripheral downstream signaling effects","","Thyroid hormone synthesis",1707.4,1932.6,1668,1700.7,1670.2,1683.4,1.0501948835644896,0.07065707214222648,0.36532307759292054,0.43732289237967176,0.5991267779553715,0.222481269195547,4761]
["High","Q9UPN9-1","E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",34,27,62,2,1127,122.5,6.67,131.34,"protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TRIM33","ENSG00000197323","Ectoderm differentiation","Downregulation of SMAD2/3:SMAD4 transcriptional activity","",2673.5,2449.6,2546.2,2825.6,2766.3,2800.2,0.913871379035045,-0.12993696449009248,0.022919083299087466,1.6398027569537568,0.15766713867777526,0.802258813824263,1135]
["High","Q9UPN9-2","Isoform Beta of E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",33,26,63,1,1110,120.5,6.67,137.02,"","","","TRIM33","","","","",179.7,169.3,153.3,179.3,181.5,154.5,0.9747719774888416,-0.03686331748119927,0.7270418137382875,0.1384406112130382,0.8448790715387035,0.07320544764413774,6719]
["High","Q9UPT8","Zinc finger CCCH domain-containing protein 4 [OS=Homo sapiens]",18,15,42,14,1303,140.2,6.27,67.32,"other biological processes","cytosol;nucleus","other molecular function","ZC3H4","ENSG00000130749","","","",1237.9,1084.4,894.7,1307.1,1024,1127.4,0.9301720399016915,-0.10443052043166022,0.5670041612150116,0.24641375383004563,0.7413209127204974,0.12999374822439808,5972]
["High","Q9UPX8","SH3 and multiple ankyrin repeat domains protein 2 [OS=Homo sapiens]",5,7,7,7,1470,158.7,6.9,10.03,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","SHANK2","ENSG00000162105","","Neurexins and neuroligins","Glutamatergic synapse",360.7,261.7,314.3,375.1,311.3,312.2,0.9380132185059081,-0.09231984150859579,0.5927691251092899,0.22711442504199242,0.7592423439720039,0.11961957871490113,6096]
["High","Q9UPY8","Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",10,3,7,1,281,32,5.54,11.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAPRE3","ENSG00000084764","","","",109.9,101.7,121.5,118.7,134.9,131.4,0.8651948051948052,-0.20890309179527494,0.084117371811746,1.075114305000067,0.2880651048711021,0.5405093473418855,2280]
["High","Q9UQB3-1","Catenin delta-2 [OS=Homo sapiens]",3,3,3,3,1225,132.6,7.74,2.46,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","CTNND2","ENSG00000169862; ENSPTRG00000016731","Ectoderm differentiation; Ectoderm differentiation","","Wnt signaling pathway",49.7,59.2,58.4,44.2,48.1,48.6,1.1873669268985096,0.24776583372871616,0.05813696806492831,1.235547621120904,0.24106927596970806,0.6178581364789334,1883]
["High","Q9Y217-1","Myotubularin-related protein 6 [OS=Homo sapiens]",8,4,6,4,621,71.9,7.66,13.34,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","MTMR6","ENSG00000139505; ENSPPAG00000035079","","Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",195.2,185,182.6,231.8,215.4,233.3,0.8270389419544452,-0.27397283315482446,0.004755840507395639,2.322772718376188,0.0736777830987007,1.1326634501630777,504]
["High","Q9Y230","RuvB-like 2 [OS=Homo sapiens]",62,26,112,26,463,51.1,5.64,212.05,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","RUVBL2","ENSG00000183207","","HATs acetylate histones; Telomere Extension By Telomerase","",5236,4359.5,5343,4957.2,5298.5,4988.3,0.9799593282602992,-0.029206221307274124,0.7730651902083355,0.11178388182035633,0.8706321945978197,0.06016527736049266,6933]
["High","Q9Y250","Leucine zipper putative tumor suppressor 1 [OS=Homo sapiens]",17,8,9,8,596,66.6,7.09,14.92,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;other cell component","cytoskeletal activity","LZTS1","ENSG00000061337","","","",328.1,336,420.3,454.7,340.2,348.4,0.94848246304557,-0.07630699569561229,0.6989470946841438,0.15555569600867614,0.8275024890513716,0.0822306912324248,6595]
["High","Q9Y277","Voltage-dependent anion-selective channel protein 3 [OS=Homo sapiens]",51,12,51,10,283,30.6,8.66,130.66,"transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","VDAC3","ENSG00000078668","Alzheimer's disease and miRNA effects; Ferroptosis; Hepatitis B infection; Alzheimer's disease","Ub-specific processing proteases; Mitochondrial calcium ion transport","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Hepatitis B; Human T-cell leukemia virus 1 infection; Viral carcinogenesis; Chemical carcinogenesis; Diabetic cardiomyopathy",1780.8,1384.5,1909.2,1689.9,2199.8,2002.9,0.8611648508298544,-0.21563865899615267,0.27676224575755076,0.5578931540182658,0.523996026885295,0.28067200597110925,4124]
["High","Q9Y282-1","Endoplasmic reticulum-Golgi intermediate compartment protein 3 [OS=Homo sapiens]",24,10,20,10,383,43.2,6.06,39.07,"transport","other membranes;ER/Golgi;other cell component","","ERGIC3","ENSCANG00000036642; ENSCATG00000041920; ENSG00000125991; ENSGGOG00000027615; ENSMFAG00000037850; ENSMLEG00000032774; ENSMNEG00000030061; ENSPANG00000011730; ENSPPAG00000037078; ENSPTRG00000013442; ENSRROG00000033106","","","",662.1,1072.4,678.1,732.2,745.9,739.5,1.0879329004329004,0.12158957938430287,0.6535506680959201,0.1847207370483121,0.7985795956952965,0.09768179054807685,6390]
["High","Q9Y2B1","UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase [OS=Homo sapiens]",5,2,2,2,443,51.1,8.32,4.19,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus","other molecular function","RXYLT1","ENSG00000118600","","","Mannose type O-glycan biosynthesis; Metabolic pathways",153.1,149,158,131.7,123.3,139.8,1.1654002026342454,0.22082546664684746,0.015990761568497908,1.7961308522562571,0.1361568880336223,0.8659603832676429,917]
["High","Q9Y2F5","Little elongation complex subunit 1 [OS=Homo sapiens]",4,7,7,7,2266,247.7,5.48,11.53,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","ICE1","ENSG00000164151","","RNA polymerase II transcribes snRNA genes","",197.6,290.7,180.5,175.2,191.7,180.7,1.2213294375456538,0.2884524008229833,0.3076009267013036,0.5120123604809568,0.5509860141509013,0.25885942484000524,4359]
["High","Q9Y2G8","DnaJ homolog subfamily C member 16 [OS=Homo sapiens]",16,8,14,8,782,90.5,7.12,37.2,"","other membranes","","DNAJC16","ENSG00000116138","","","",477.9,374.3,518.5,470.6,453.3,486.1,0.9721276595744681,-0.04078231424391361,0.780559322227566,0.1075940851229475,0.8759136516172514,0.057538704875882224,6958]
["Medium","Q9Y2I8","WD repeat-containing protein 37 [OS=Homo sapiens]",1,1,1,1,494,54.6,7.23,2.3,"","nucleus;other cell component","","WDR37","ENSG00000047056","","","",85.7,78.2,91.8,123.8,92.6,99.7,0.8089212274596648,-0.30592887466284946,0.1203873522672627,0.9194191370737217,0.3457096162202233,0.4612885400025864,2719]
["High","Q9Y2J4","Angiomotin-like protein 2 [OS=Homo sapiens]",6,4,4,4,779,85.7,7.3,6.13,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","AMOTL2","ENSG00000114019","","Signaling by Hippo","Tight junction",201.4,232.3,187.5,164.7,135.5,160.4,1.3486756404689537,0.43154341859445583,0.029050070147692782,1.5368528145741973,0.17610477306924321,0.7542288729393553,1288]
["High","Q9Y2R0","Cytochrome c oxidase assembly factor 3 homolog, mitochondrial [OS=Homo sapiens]",26,3,6,3,106,11.7,9.6,12.73,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion","","COA3","ENSG00000183978","Mitochondrial complex IV assembly","","Thermogenesis",121.6,149.7,170.5,201.8,219.1,201.9,0.7093770070648683,-0.4953755257237624,0.016878710641501114,1.7726607320390566,0.1396069625941109,0.8550929216784902,944]
["High","Q9Y2R9","28S ribosomal protein S7, mitochondrial [OS=Homo sapiens]",17,3,5,3,242,28.1,9.99,8.48,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS7","ENSG00000125445","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",196.3,215.4,274.3,291,239.7,233.2,0.8980233014792511,-0.15517521507414808,0.4320428339990132,0.3644731938165183,0.6506056794338082,0.18668214988294266,5185]
["High","Q9Y2V7-1","Conserved oligomeric Golgi complex subunit 6 [OS=Homo sapiens]",10,7,11,7,657,73.2,5.76,22.47,"other metabolic processes;transport","other membranes;ER/Golgi","","COG6","ENSG00000133103","","COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",482.7,338.5,505.1,453.7,555.3,503.2,0.877066525591853,-0.18924181949048266,0.35918992614298056,0.44467585207674176,0.5951941730314925,0.22534132919715155,4712]
["High","Q9Y2Y0","ADP-ribosylation factor-like protein 2-binding protein [OS=Homo sapiens]",34,5,13,5,163,18.8,4.35,32,"signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","ARL2BP","ENSG00000102931","Ciliopathies","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane","",423.3,269.6,449.8,415.8,399.3,366.9,0.9667512690355331,-0.04878334178039842,0.8323246685311603,0.079707233508112,0.906892410255554,0.042444232679568344,7166]
["Low","Q9Y2Z2","Protein MTO1 homolog, mitochondrial [OS=Homo sapiens]",1,1,1,1,717,79.9,8.31,0,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","MTO1","ENSG00000135297","","tRNA modification in the mitochondrion","",7.7,9.3,16.1,18.4,15.4,18.1,0.6377649325626203,-0.6489033215506633,0.08459813646655065,1.0726392035237156,0.28907757091064656,0.5389856032709492,2285]
["High","Q9Y2Z4","Tyrosine--tRNA ligase, mitochondrial [OS=Homo sapiens]",45,17,69,17,477,53.2,8.98,146.02,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","YARS2","ENSG00000139131","Orexin receptor pathway","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",2319.4,2286.3,2348.6,2482.8,2645.9,2555.6,0.9050011061515036,-0.14400853933426686,0.00852611414505634,2.0692488574458334,0.10101957396752641,0.9955944673812078,659]
["Medium","Q9Y2Z9-1","Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [OS=Homo sapiens]",2,1,1,1,468,50.8,7.3,0,"other metabolic processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","COQ6","ENSG00000119723","Nephrotic syndrome","Ubiquinol biosynthesis","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",31.7,27.3,33,41.1,45.2,42.8,0.7126258714175058,-0.4887832343628155,0.00412111657825273,2.3849850999680684,0.06817304712499432,1.1663872939435207,472]
["High","Q9Y303","N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",16,5,6,5,409,43.7,6.7,13.48,"other metabolic processes","cytosol","other molecular function","AMDHD2","ENSG00000162066","","Synthesis of UDP-N-acetyl-glucosamine","Amino sugar and nucleotide sugar metabolism; Metabolic pathways",163.7,159.4,179.7,208.8,215.4,176.8,0.8366056572379367,-0.2573803411780402,0.07134244276129262,1.1466520245240512,0.2672945264300253,0.5730099344929027,2084]
["High","Q9Y305-1","Acyl-coenzyme A thioesterase 9, mitochondrial [OS=Homo sapiens]",31,12,33,12,439,49.9,8.6,73.44,"other metabolic processes","mitochondrion","other molecular function","ACOT9","ENSG00000123130","VEGFA-VEGFR2 signaling pathway","Mitochondrial Fatty Acid Beta-Oxidation","",1110.5,1066.1,1119.8,1140.4,1213.4,1196.2,0.9285633802816902,-0.10692770836975678,0.03742611970672421,1.4268251976601978,0.1939105127207051,0.7123986453161942,1507]
["High","Q9Y312","Protein AAR2 homolog [OS=Homo sapiens]",29,8,27,8,384,43.4,5.96,31.97,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","","AAR2","ENSG00000131043","Ciliary landscape","","",493.6,516,459.7,418.8,379.8,402.4,1.2233971690258119,0.290892842756762,0.010853413020782519,1.9644336698330507,0.11299126515502655,0.9469551285661153,750]
["High","Q9Y314","nitric oxide synthase-interacting protein [OS=Homo sapiens]",47,9,14,9,301,33.2,8.82,34.49,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","NOSIP","ENSG00000142546","","NOSIP mediated eNOS trafficking","",516.9,442,535.4,493.9,478.2,470.3,1.035981697171381,0.05099851496140196,0.5876675582822184,0.23086828350357297,0.7563059658921314,0.12130247378898582,6067]
["High","Q9Y315","deoxyribose-phosphate aldolase [OS=Homo sapiens]",31,9,19,9,318,35.2,8.94,32.66,"other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","DERA","ENSG00000023697","Pentose phosphate pathway in senescent cells","Neutrophil degranulation; Pentose phosphate pathway","Pentose phosphate pathway; Metabolic pathways",663,551.5,738.2,704.3,767.4,756.5,0.8763575980612154,-0.19040841264354058,0.18623393332049568,0.7299411841970097,0.42667680497841265,0.36990096563303676,3408]
["High","Q9Y316-1","Protein MEMO1 [OS=Homo sapiens]",21,5,11,5,297,33.7,7.14,22.28,"other biological processes","","other molecular function","LOC111154137; LOC114499315; MEMO1","ENSANAG00000021250; ENSCANG00000020056; ENSCATG00000030724; ENSCCAG00000037443; ENSCHIG00000006439; ENSCJAG00000003208; ENSDLEG00000015222; ENSECAG00000019946; ENSFCAG00000001385; ENSG00000162959; ENSHGLG00000018935; ENSMMUG00000003908; ENSMNEG00000040106; ENSMODG00000047380; ENSPANG00000022798; ENSPCOG00000018130; ENSPCTG00005009736; ENSPTRG00000050445; ENSRFEG00010015180; ENSSSCG00000008515; ENSSSCG00070008027; ENSVURG00010020209; ENSVVUG00000007616","","ERBB2 Regulates Cell Motility; ERBB2 Regulates Cell Motility","",539.3,479.5,520.9,587.9,533.6,570,0.9102571681939104,-0.13565389807822867,0.10096703596407895,0.9958203929067635,0.3166066734166781,0.4994799353438645,2490]
["High","Q9Y320","Thioredoxin-related transmembrane protein 2 [OS=Homo sapiens]",29,7,29,7,296,34,8.69,56.44,"developmental processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","TMX2","ENSG00000213593","","","",1278.6,1362.8,1330.5,1353.1,1503.5,1405.1,0.9319989675481615,-0.10159973819876435,0.12810120316939436,0.8924467911969619,0.35506361176664225,0.4496938335240998,2817]
["High","Q9Y324","rRNA-processing protein FCF1 homolog [OS=Homo sapiens]",10,2,3,2,198,23.4,9.7,7.51,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","FCF1","ENSG00000119616","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",116.6,114.1,128.2,112.3,112.1,111.1,1.0697466467958272,0.0972691567285317,0.14809177735861004,0.829469054557251,0.3793637131286179,0.4209442125661784,3048]
["High","Q9Y333","U6 snRNA-associated Sm-like protein LSm2 [OS=Homo sapiens]",67,5,22,5,95,10.8,6.52,32.21,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM2","ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",523.1,435.1,631,605.4,915.7,753.1,0.6987951807228916,-0.5170584362193527,0.09756557884947895,1.0107033744686753,0.3114440064009532,0.5066200225103066,2446]
["High","Q9Y365","START domain-containing protein 10 [OS=Homo sapiens]",4,1,1,1,291,33,7.12,3.13,"transport","other membranes;cytosol;cytoskeleton;other cell component","other molecular function","STARD10","ENSG00000214530","","Synthesis of PC","",9.5,12.4,12.5,15.4,14.9,14.1,0.7747747747747749,-0.3681511116480079,0.03410942316740967,1.4671256249880649,0.18742179879742063,0.7271798982568992,1421]
["High","Q9Y366","Intraflagellar transport protein 52 homolog [OS=Homo sapiens]",9,2,4,2,437,49.7,5.26,10.33,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","IFT52","ENSG00000101052","Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",33.9,32.6,34.4,38.8,39.6,38.4,0.8638698630136985,-0.2111140997736602,1.1748246555154437E-3,2.9300269477110814,0.039034174086232276,1.4085550053241824,235]
["High","Q9Y371","Endophilin-B1 [OS=Homo sapiens]",36,11,39,10,365,40.8,6.04,80.37,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GLB1","ENSG00000097033","Nanoparticle triggered autophagic cell death","","Autophagy; Endocytosis",1846.5,1772.3,1861.6,2033.9,1987.2,2004.3,0.9095495734723005,-0.13677582319686826,0.004125378850858671,2.384536162197139,0.06795560773735126,1.1677746992125886,474]
["High","Q9Y375","Complex I intermediate-associated protein 30, mitochondrial [OS=Homo sapiens]",33,9,17,9,327,37.7,7.64,48.38,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion","other molecular function","NDUFAF1","ENSG00000137806","Mitochondrial immune response to SARS-CoV-2","Complex I biogenesis","Thermogenesis",729.8,636.8,716.9,641,628.4,629.4,1.097271961238677,0.1339211451604789,0.10408591559061219,0.9826080331705989,0.32122641459743084,0.4931887496877813,2530]
["High","Q9Y376","Calcium-binding protein 39 [OS=Homo sapiens]",36,13,28,12,341,39.8,6.89,47.44,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CAB39","ENSG00000135932","AMP-activated protein kinase (AMPK) signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias","Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK","mTOR signaling pathway; AMPK signaling pathway",1659.9,1483.2,1736.9,1482.3,1566.7,1514.2,1.0694249649368865,0.0968352608937231,0.25241311235647906,0.597888088111941,0.49945301096791395,0.301505364369478,3946]
["High","Q9Y383","Putative RNA-binding protein Luc7-like 2 [OS=Homo sapiens]",41,19,111,13,392,46.5,10.01,244.56,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","LUC7L2","ENSG00000146963","","","",5299.6,5480,5089.2,5251.5,4803.1,5112.2,1.0462853073819132,0.06527630800890333,0.2500837544541413,0.6019145193053881,0.497111495615564,0.3035461937616648,3928]
["High","Q9Y388","RNA-binding motif protein, X-linked 2 [OS=Homo sapiens]",10,4,10,4,322,37.3,9.83,19.58,"RNA metabolism OR transcription;other metabolic processes","nucleus","","RBMX2","ENSG00000134597","","","",463.2,456,466.6,593.6,600.6,585.1,0.7788456134434891,-0.3605907162712521,1.7851512289360088E-5,4.74832498677286,0.007743589330851309,2.111057687217531,18]
["High","Q9Y394","Dehydrogenase/reductase SDR family member 7 [OS=Homo sapiens]",9,2,3,2,339,38.3,8.32,2.66,"","","other molecular function","DHRS7","ENSG00000100612","","","",104,156.6,122.2,117.6,101.1,133.2,1.0878090366581417,0.1214253157363611,0.5976563587948969,0.22354845543706853,0.7622510371562486,0.11790197603974902,6122]
["High","Q9Y399","28S ribosomal protein S2, mitochondrial [OS=Homo sapiens]",18,6,9,6,296,33.2,9.26,9.57,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS2","ENSG00000122140","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",354,273.3,338.1,353,377.8,342,0.8998881431767339,-0.15218241045987124,0.25337139082476134,0.5962424246079793,0.5002082982451925,0.3008491077830393,3955]
["High","Q9Y3A3","MOB-like protein phocein [OS=Homo sapiens]",46,7,35,7,225,26,5.78,49.95,"","other membranes;ER/Golgi;other cell component","other molecular function","MOB4","ENSG00000115540","","","",646.3,605.9,724.6,772.4,925.9,797.8,0.7919554505027843,-0.33650881754508605,0.04246033143711803,1.3720166201382331,0.20540908789406295,0.6873803458656493,1614]
["High","Q9Y3A4","Ribosomal RNA-processing protein 7 homolog A [OS=Homo sapiens]",29,7,16,7,280,32.3,9.58,27.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","","RRP7A","ENSG00000189306","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",660.6,841.7,746.3,866.3,783.4,707.9,0.9537665422463523,-0.06829192043973395,0.6286723591350484,0.20157563387442826,0.7811384118597164,0.10727200558372853,6284]
["High","Q9Y3A5","Ribosome maturation protein SBDS [OS=Homo sapiens]",61,20,70,20,250,28.7,8.75,104.87,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity","SBDS","ENSG00000126524","","","Ribosome biogenesis in eukaryotes",3359.7,3235,3954.2,3269.7,3450.3,3262.6,1.0567287079518362,0.07960504376992418,0.4583194300426381,0.33883173083849955,0.6660260766374313,0.17650876674855806,5373]
["High","Q9Y3A6-1","Transmembrane emp24 domain-containing protein 5 [OS=Homo sapiens]",12,3,5,3,229,26,4.84,9.42,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED5","ENSG00000117500","","WNT ligand biogenesis and trafficking","",231.9,174.5,225.2,200.8,214,228.5,0.9818125291465879,-0.026480517486401678,0.8535078328359229,0.06879248891150937,0.9188183039821985,0.03677036171462027,7253]
["High","Q9Y3B2","Exosome complex component csl4 [OS=Homo sapiens]",24,3,8,3,195,21.4,8.24,24.08,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EXOSC1","ENSG00000171311","","Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","RNA degradation",184.5,175.1,242.2,226.1,336.5,297.7,0.6995234220620714,-0.5155557310969289,0.08905610687035413,1.050336294177604,0.2980497567268432,0.5257112283127211,2333]
["High","Q9Y3B3-1","Transmembrane emp24 domain-containing protein 7 [OS=Homo sapiens]",25,5,15,5,224,25.2,6.89,25.06,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED7","ENSG00000134970; ENSPTRG00000017152","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",591.2,428,668.8,587.8,822.7,773.1,0.7730353544605238,-0.37139369815187023,0.17632177244278485,0.7536940571394932,0.41530027126191976,0.3816377852216498,3315]
["High","Q9Y3B4","Splicing factor 3B subunit 6 [OS=Homo sapiens]",34,4,4,4,125,14.6,9.38,8.97,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","SF3B6","ENSG00000115128","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",194.7,267.8,195.2,302.4,227.9,210.3,0.8880637321091008,-0.17126487923720313,0.49922760494964585,0.30170140820976815,0.695072956392089,0.157969608509735,5608]
["High","Q9Y3B6","ER membrane protein complex subunit 9 [OS=Homo sapiens]",8,1,1,1,208,23,5.91,3.52,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC9","ENSG00000100908; ENSG00000285377","","","",22.5,15.8,18.8,24.6,17.1,18.3,0.9516666666666665,-0.07147175513303827,0.7654661481867788,0.11607401068846483,0.8669509261738277,0.06200548510175829,6894]
["High","Q9Y3B7-1","39S ribosomal protein L11, mitochondrial [OS=Homo sapiens]",43,9,19,9,192,20.7,9.91,33.13,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL11","ENSG00000174547; ENSPPAG00000028194; ENSPTRG00000003924","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",944,836.2,933.4,899.6,984.1,988.8,0.9446823324630113,-0.08209881785763888,0.30357242424442904,0.5177376812034252,0.5469066655515694,0.26208678352858894,4334]
["High","Q9Y3B8-1","Oligoribonuclease, mitochondrial [OS=Homo sapiens]",34,6,27,6,237,26.8,6.87,49.9,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","REXO2","ENSG00000076043; ENSPPAG00000039849; ENSPTRG00000004306","","","Ribosome biogenesis in eukaryotes",716.4,803,924.2,1286.3,1023.5,1028.2,0.7320551228280407,-0.4499758091697158,0.04778947098963697,1.3206677769191124,0.2198822566217357,0.6578098145781529,1697]
["High","Q9Y3B9","RRP15-like protein [OS=Homo sapiens]",18,5,23,5,282,31.5,5.52,39.06,"RNA metabolism OR transcription;other metabolic processes","other cell component","","RRP15","ENSG00000067533","","","",1038.9,1018,980.1,1208.6,1025.6,1004.2,0.9378087944664034,-0.09263428663948765,0.37372376282366027,0.42744928712470526,0.6060301433285855,0.2175057739266232,4815]
["High","Q9Y3C0","WASH complex subunit 3 [OS=Homo sapiens]",17,2,2,2,194,21.2,4.46,0,"cell organization and biogenesis;transport","other cytoplasmic organelle;other cell component","","WASHC3","ENSG00000120860","","","Endocytosis",25,20.9,23.4,24,18.1,23.1,1.0628834355828218,0.08798338790613584,0.5662282724452516,0.24700844959398904,0.7408026727970048,0.130297459399966,5968]
["High","Q9Y3C1","nucleolar protein 16 [OS=Homo sapiens]",17,3,6,3,178,21.2,9.94,8.83,"other biological processes","nucleus;other cell component","","NOP16","ENSG00000048162","","","",270.5,297.9,269.7,410.1,273.7,258.7,0.889230769230769,-0.16937022541513833,0.5171586563725018,0.2863762015545458,0.7080439749178492,0.14993976848101595,5703]
["High","Q9Y3C4","EKC/KEOPS complex subunit TPRKB [OS=Homo sapiens]",14,2,9,2,175,19.6,6.79,12.12,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","TPRKB","ENSG00000144034","","tRNA modification in the nucleus and cytosol","",215.2,247.5,234.1,229,231.6,235.3,1.001293289265699,1.8646165255183354E-3,0.9764342635101558,0.010356989402014698,0.9866699533437683,0.005828096988407986,7727]
["High","Q9Y3C5","Ring finger protein 11 [OS=Homo sapiens]",8,1,2,1,154,17.4,4.78,3.26,"protein metabolism;other metabolic processes","nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","RNF11","ENSG00000123091","","","",48.5,62.3,66.6,56.6,52.1,50.1,1.1171284634760703,0.1597950971581058,0.34442561560109114,0.4629045566942511,0.5836100708796267,0.2338772224507713,4608]
["High","Q9Y3C6","Peptidyl-prolyl cis-trans isomerase-like 1 [OS=Homo sapiens]",40,6,42,6,166,18.2,7.99,66.58,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","PPIL1","ENSG00000137168","","mRNA Splicing - Major Pathway","Spliceosome",2091.6,2423,2267.8,2439.8,2294.7,2322.2,0.9611291396828547,-0.057197806798851406,0.4352868597890891,0.3612244428982519,0.6522202650610647,0.18560571140637752,5211]
["High","Q9Y3C8","ubiquitin-fold modifier-conjugating enzyme 1 [OS=Homo sapiens]",26,5,12,5,167,19.4,7.4,25.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes","","other molecular function","UFC1","ENSG00000143222","","","",426.1,438,506.7,535.4,529.7,482,0.8860448581216471,-0.1745483544011987,0.12437736368685662,0.9052586527675891,0.35033854822041,0.4555120740487228,2772]
["High","Q9Y3D0","Mitotic spindle-associated MMXD complex subunit MIP18 [OS=Homo sapiens]",26,2,2,2,163,17.7,5.19,7.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CIAO2B","ENSG00000166595","","Cytosolic iron-sulfur cluster assembly","",40.2,59.9,49.6,62.7,38.3,34.6,1.1039823008849559,0.14271704292207296,0.6773523812328863,0.16918533809397351,0.8135313632773998,0.08962569947481853,6501]
["High","Q9Y3D2","Methionine-R-sulfoxide reductase B2, mitochondrial [OS=Homo sapiens]",21,2,3,2,182,19.5,8.63,5.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","MSRB2","ENSG00000148450","Sulindac metabolic pathway; Methionine de novo and salvage pathway","Protein repair","",34.8,34.7,38.5,31.4,25.4,36.3,1.1600429645542427,0.21417823949203715,0.21685316003998423,0.6638342448182938,0.4594815396451009,0.33773193235472865,3685]
["High","Q9Y3D3","28S ribosomal protein S16, mitochondrial [OS=Homo sapiens]",23,2,4,2,137,15.3,9.5,7.77,"protein metabolism;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","other molecular function","MRPS16","ENSG00000182180","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",73,99.1,79.5,93.9,83.2,79.8,0.9793694044375242,-0.0300749680215279,0.8526733584749124,0.0692173062064358,0.9185531985336806,0.03689568621655704,7248]
["High","Q9Y3D6","mitochondrial fission 1 protein [OS=Homo sapiens]",12,2,9,2,152,16.9,8.79,17.75,"cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FIS1","ENSG00000214253","CAMKK2 pathway","Class I peroxisomal membrane protein import","Mitophagy",322.8,226.4,312.5,266,300.8,312.1,0.9804300830583685,-0.02851334302321241,0.8726545839826163,0.05915762565924621,0.9294348645118358,0.03178104050669705,7331]
["High","Q9Y3D8","Adenylate kinase isoenzyme 6 [OS=Homo sapiens]",56,5,10,5,172,20,4.58,15.84,"other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AK6","ENSG00000085231; ENSG00000279247","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Metabolic pathways; Biosynthesis of cofactors; Ribosome biogenesis in eukaryotes",168.7,155,223.9,268.6,292.7,259.7,0.6669914738124239,-0.5842597754072677,0.0172543024016835,1.763102594716384,0.14106973104957568,0.850566161641495,955]
["High","Q9Y3D9","28S ribosomal protein S23, mitochondrial [OS=Homo sapiens]",11,2,3,2,190,21.8,8.9,7.9,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS23","ENSG00000181610","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",195.8,195.9,199.8,243,214.6,198,0.9022269676632092,-0.14843768587230818,0.1809371191832093,0.7424723286473499,0.4212155714318718,0.3754955822587814,3354]
["High","Q9Y3E0","vesicle transport protein GOT1B [OS=Homo sapiens]",17,3,44,3,138,15.4,10.36,91.96,"transport","other membranes;ER/Golgi;other cell component","","GOLT1B","ENSG00000111711","","","",2268.5,2271.7,2366,2581.7,2585.7,2482.8,0.9027476405845599,-0.14760535032702016,0.005917410789755938,2.2278682807260903,0.0813435624056591,1.0896768117784739,568]
["High","Q9Y3E1","Hepatoma-derived growth factor-related protein 3 [OS=Homo sapiens]",30,5,21,4,203,22.6,7.99,36.17,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","HDGFL3","ENSG00000166503","","","",691.6,590.2,634.1,706.2,749.3,733.1,0.8753997989582382,-0.19198604223549498,0.04657158401634722,1.331878990371765,0.2167049630510364,0.6641311422058112,1678]
["High","Q9Y3E5","Peptidyl-tRNA hydrolase 2, mitochondrial [OS=Homo sapiens]",21,2,5,2,179,19.2,8.73,12.87,"other biological processes","cytosol;mitochondrion","other molecular function","PTRH2","ENSG00000141378","Apoptosis modulation and signaling","Ub-specific processing proteases","",137.7,96.3,160.2,142.9,143.2,139,0.9273112208892025,-0.10887448259568902,0.612226677712246,0.21308774999058616,0.7702652110179209,0.11335971658009768,6206]
["High","Q9Y3E7","Charged multivesicular body protein 3 [OS=Homo sapiens]",9,2,4,2,222,25.1,5.12,5.58,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","CHMP3","ENSG00000115561","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Endocytosis; Necroptosis",75.8,43,81.7,68.2,74.9,74.1,0.9231123388581951,-0.11542186646207908,0.6723982037453099,0.17237345541183788,0.8104484678671472,0.0912745944273606,6478]
["High","Q9Y3F4","Serine-threonine kinase receptor-associated protein [OS=Homo sapiens]",68,21,239,21,350,38.4,5.12,565.03,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","STRAP","ENSG00000023734","TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer","Downregulation of TGF-beta receptor signaling","",8767.3,10621.1,8683.7,8540.5,8463,8673.1,1.093295062430384,0.12868281332196826,0.27718083870635774,0.5572367954589419,0.5245341707753857,0.2802262144374392,4126]
["High","Q9Y3I0","tRNA-splicing ligase RtcB homolog [OS=Homo sapiens]",56,25,115,25,505,55.2,7.23,254.71,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","RTCB","ENSG00000100220","Unfolded protein response","tRNA processing in the nucleus","",5727.7,4809.2,5847.3,5732.9,5701.4,5797.7,0.9508008356545962,-0.07278492362824736,0.4389738888735019,0.35756131177475625,0.6536056682540624,0.18468419013416745,5244]
["High","Q9Y3L3-1","SH3 domain-binding protein 1 [OS=Homo sapiens]",15,8,16,8,701,75.7,6.77,35.16,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SH3BP1","ENSG00000100092","","RAC1 GTPase cycle","",596.2,499.9,599.1,662.6,614.5,642.8,0.8829626543049117,-0.17957567580014988,0.1022098737118243,0.9905071483164296,0.3180768010928354,0.4974680049724048,2509]
["High","Q9Y3M8-4","Isoform 4 of StAR-related lipid transfer protein 13 [OS=Homo sapiens]",3,3,3,2,1078,120.6,6.95,8.94,"","","","STARD13","","","","",120.5,112.9,132,106.2,97.6,128.3,1.100271002710027,0.13785891112478016,0.3580312217613133,0.44607909948065716,0.5941568075477862,0.2260989225852975,4705]
["High","Q9Y3P9","Rab GTPase-activating protein 1 [OS=Homo sapiens]",26,22,38,20,1069,121.7,5.25,80,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity;other molecular function","RABGAP1","ENSG00000011454","","TBC/RABGAPs","",1501.3,1263.7,1390.7,1221.1,1181,1205,1.1520889357101274,0.20425209017908494,0.05840370479074833,1.2335596029022293,0.2414061021737231,0.6172517561654275,1889]
["High","Q9Y3Q3","Transmembrane emp24 domain-containing protein 3 [OS=Homo sapiens]",9,2,7,2,217,24.8,5.6,19.2,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED3","ENSG00000166557","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",418.7,310.5,400,420.9,499.5,430.6,0.8358253145817913,-0.2587266407633539,0.14984803132603086,0.8243489583563595,0.38073980754755904,0.4193717139541023,3073]
["High","Q9Y3Q4","Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [OS=Homo sapiens]",2,2,2,2,1203,129,8.91,2.14,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","HCN4","ENSG00000138622","Genes targeted by miRNAs in adipocytes","HCN channels","cAMP signaling pathway; Taste transduction",59.6,51.8,51.6,43.1,39.3,44.6,1.2834645669291338,0.36004346745891164,0.0174135462033618,1.7591127774338664,0.14148279787289172,0.8492963604437764,961]
["High","Q9Y3R0","Glutamate receptor-interacting protein 1 [OS=Homo sapiens]",4,3,4,3,1128,122.3,6.47,2.15,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","GRIP1","ENSG00000155974","Brain-derived neurotrophic factor (BDNF) signaling pathway; Fragile X syndrome; 7q11.23 copy number variation syndrome; Development of ureteric collection system","Trafficking of GluR2-containing AMPA receptors","",16.8,25,14.2,17.5,15.4,18,1.100196463654224,0.1377611708692713,0.6385749940262258,0.19478809201181765,0.7887982207493704,0.10303407768094489,6321]
["High","Q9Y3R5-1","Protein dopey-2 [OS=Homo sapiens]",3,5,5,5,2298,258.1,6.29,4.3,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","DOP1B","ENSG00000142197","","","",106.4,86.4,114.9,87.1,106.9,88,1.0911347517730499,0.12582928104738916,0.4655468497070385,0.33203660781811467,0.671653695955757,0.17285459108506462,5412]
["High","Q9Y3S1-1","Serine/threonine-protein kinase WNK2 [OS=Homo sapiens]",12,25,42,17,2297,242.5,6.13,74.88,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","WNK2","ENSG00000165238","","Stimuli-sensing channels","",1788.4,1603.9,1772.5,1733.5,1775,1722.4,0.9873635512053377,-0.01834670630610358,0.7368748006723082,0.13260629503927956,0.8502317782842296,0.07046266686411322,6767]
["High","Q9Y3S2","zinc finger protein 330 [OS=Homo sapiens]",24,7,19,7,320,36.2,6.16,30.55,"","nucleus;other cell component","other molecular function","ZNF330","ENSG00000109445","","","",679,865.2,691.7,686,648.6,631.6,{"$f":"AVERAGE(T7618:V7618)/AVERAGE(W7618:Y7618)","v":1.1371681415929205},{"$f":"LOG(Z7618,2)","v":0.18544558677869052},{"$f":"TTEST(T7618:V7618,W7618:Y7618,2,2)","v":0.22172459375416115},{"$f":"-LOG10(AB7618)","v":0.6541861321478772},{"$f":"AB7618*7808/AF7618","v":0.4648833587627525},{"$f":"-LOG10(AD7618)","v":0.3326559997985468},3724]
["High","Q9Y3T6","R3H and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",10,4,5,4,440,49.1,5.63,11.19,"","","nucleic acid binding activity","R3HCC1","ENSG00000104679","","","",198.1,209.7,185.8,195.5,242.6,179.7,0.9608287471673681,-0.057648779006834384,0.7088704262735197,0.1494331418227923,0.8331868565924494,0.07925758960570643,6643]
["High","Q9Y3T9","Nucleolar complex protein 2 homolog [OS=Homo sapiens]",27,18,61,18,749,84.9,5.62,100.48,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","other molecular function","NOC2L","ENSG00000188976","","Regulation of TP53 Activity through Phosphorylation","",2440.5,1886.9,2606,2497.6,2806.9,2703.2,0.8658416274335952,-0.20782493161091342,0.20325178417563333,0.6919656334129526,0.44578368843914185,0.3508758267271924,3560]
["High","Q9Y3U8","60S ribosomal protein L36 [OS=Homo sapiens]",21,2,9,2,105,12.2,11.59,23.05,"protein metabolism;other metabolic processes","cytosol;translational apparatus;nucleus","other molecular function","RPL36","ENSG00000130255","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",420.5,440.7,494.6,454.2,397.3,369.8,1.1101285515434376,0.15072674858956203,0.24903996379758564,0.6037309554580096,0.4973156105707286,0.3033679081952409,3910]
["High","Q9Y3X0","coiled-coil domain-containing protein 9 [OS=Homo sapiens]",11,5,7,5,531,59.7,5.4,15.69,"","","","CCDC9","ENSG00000105321","IL-18 signaling pathway","","",283.9,278.2,245.6,375.9,273.4,202.5,0.948227283399859,-0.07669519047587779,0.7903744598622239,0.10216710197320363,0.8828674939347989,0.054104473060249604,6990]
["High","Q9Y3Z3","deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [OS=Homo sapiens]",40,24,80,24,626,72.2,7.14,136.63,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMHD1","ENSG00000101347","","Interferon alpha/beta signaling; Nucleotide catabolism","Human immunodeficiency virus 1 infection",3085.3,2704.7,2997.9,2893.3,2852.4,2808.5,1.0273199130251804,0.038885514728087905,0.5441674604719102,0.26426743124424673,0.7253088991745774,0.13947699393119123,5858]
["High","Q9Y426","C2 domain-containing protein 2 [OS=Homo sapiens]",10,4,6,4,696,75.5,6.92,13.35,"","other membranes","","C2CD2","ENSG00000157617","","","",120,76.9,136.4,135.8,158.7,137.3,0.7718851320055582,-0.373541925912257,0.16281755477017293,0.7882987718743303,0.39927118958715774,0.3987320262813263,3184]
["Low","Q9Y448","Small kinetochore-associated protein [OS=Homo sapiens]",2,1,1,1,316,35.4,6.3,1.83,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KNSTRN","ENSG00000128944","Leukocyte-intrinsic Hippo pathway functions","","",60.5,45.1,77.6,120.7,78.4,68.1,0.68562874251497,-0.5445005043771085,0.20729270534004143,0.6834159805221953,0.4495948453597343,0.34717867663084717,3600]
["High","Q9Y450-1","HBS1-like protein [OS=Homo sapiens]",28,15,37,15,684,75.4,6.61,87.73,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol","nucleic acid binding activity;other molecular function","HBS1L","ENSG00000112339","","mRNA decay by 3' to 5' exoribonuclease","mRNA surveillance pathway; Legionellosis",1382.8,1301.8,1352.8,1412.7,1355.3,1368.1,0.9761369405962138,-0.03484453966018395,0.32511317056374134,0.4879654365718641,0.5662466285437636,0.2469943707790206,4483]
["Medium","Q9Y458-1","T-box transcription factor TBX22 [OS=Homo sapiens]",2,1,2,1,520,57.9,7.33,2.14,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TBX22","ENSG00000122145; ENSG00000277800","","","",55.9,40.5,58.6,71.9,45.8,53.6,0.9048453006421482,-0.14425693592239922,0.600607757764728,0.22140906252555873,0.7642674987984023,0.11675460880784784,6136]
["High","Q9Y462","Zinc finger protein 711 [OS=Homo sapiens]",4,2,2,2,761,86.2,6.87,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF711","ENSG00000147180","","Generic Transcription Pathway","",44.4,37.1,43.6,41.9,37.1,41.2,1.0407653910149748,0.05764489345463401,0.5850354763333512,0.23281779766369914,0.7547846991425655,0.12217691235621281,6052]
["High","Q9Y467","sal-like protein 2 [OS=Homo sapiens]",24,14,35,13,1007,105.2,6.3,102.72,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SALL2","ENSG00000165821","","","",1429.9,1563.6,1426.8,1683.9,1577.8,1593,0.9105197025562857,-0.1352378591539969,0.060815329836865745,1.2159869334841114,0.24590683343668965,0.6092294026048707,1931]
["High","Q9Y467-3","Isoform 2 of Sal-like protein 2 [OS=Homo sapiens]",13,1,3,1,198,20.9,4.77,9.61,"","","","SALL2","","","","",65.6,92.9,60.1,87,60.7,70,1.0041341295360589,0.005951993483698071,0.98233212814746,0.007741651688769074,0.9903226929083754,4.223269125358484E-3,7745]
["High","Q9Y478","5'-AMP-activated protein kinase subunit beta-1 [OS=Homo sapiens]",11,2,2,2,270,30.4,6.4,5.7,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","PRKAB1","ENSG00000111725","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma","Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy",134.1,91.8,121.5,126,117.5,125.9,0.940443963183541,-0.08858611227204527,0.5987867933410747,0.2227277868900178,0.7629450526121264,0.11750673885592994,6128]
["High","Q9Y483","Metal-response element-binding transcription factor 2 [OS=Homo sapiens]",9,4,4,4,593,67.1,8.72,8.81,"","","","","","","","",157.6,148.4,175.6,213,210.3,221.6,0.7467824468909908,-0.42124007744769165,0.003305656212740174,2.480742314912622,0.06249531164425007,1.2041525619103874,413]
["High","Q9Y484-1","WD repeat domain phosphoinositide-interacting protein 4 [OS=Homo sapiens]",3,1,1,1,360,39.8,7.14,2.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;other cell component","other molecular function","WDR45","ENSCANG00000035794; ENSCSAG00000012964; ENSG00000196998; ENSGGOG00000000589; ENSMFAG00000032970; ENSMLEG00000042347; ENSMMUG00000010620","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway","Macroautophagy","",97.2,93.3,85.2,94.7,82.7,91.3,1.026051358392259,0.037102945997024614,0.6664904599206561,0.17620606265442584,0.8063150776356497,0.09349521906367662,6454]
["High","Q9Y485","DmX-like protein 1 [OS=Homo sapiens]",5,10,10,9,3027,337.6,6.34,18.22,"other biological processes","other cell component","","DMXL1","ENSG00000172869","","","Lysosome",321.5,247.2,320.8,364.7,410.9,380.2,0.7695968160581416,-0.3778252644210805,0.03437222365723998,1.4637923709517955,0.18807170449595637,0.7256765394078071,1427]
["High","Q9Y487","V-type proton ATPase 116 kDa subunit a isoform 2 [OS=Homo sapiens]",20,13,19,12,856,98,6.61,26.08,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V0A2","ENSG00000185344","","Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; ROS and RNS production in phagocytes","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Human papillomavirus infection; Rheumatoid arthritis",495.7,417.6,530.4,519.2,554.5,495.3,0.920140216698534,-0.12007437010712325,0.3280957517320089,0.48399939293394895,0.5687770047787579,0.2450579701186033,4504]
["High","Q9Y490","Talin-1 [OS=Homo sapiens]",61,118,456,100,2541,269.6,6.07,1103.31,"cell adhesion;cell organization and biogenesis;signal transduction","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN1","ENSG00000137076","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion","Signaling by BRAF and RAF1 fusions; p130Cas linkage to MAPK signaling for integrins; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Platelet degranulation ; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection",18658.2,17722.5,18198.1,18608.7,18607.5,18838.2,0.9736755723011931,-0.038486947015540056,0.15472013688431224,0.8104531590310117,0.38645387997207614,0.4129023280555444,3126]
["High","Q9Y496","kinesin-like protein KIF3A [OS=Homo sapiens]",11,7,8,7,699,80,6.54,14.44,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3A","ENSG00000131437","Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO","Hedgehog signaling pathway",358.7,310.4,366.9,346.4,326.4,315.2,1.048582995951417,0.06844105610187626,0.46537328332474903,0.3321985528019452,0.6715273694695325,0.17293628207589154,5411]
["High","Q9Y4A5","Transformation/transcription domain-associated protein [OS=Homo sapiens]",15,43,73,43,3859,437.3,8.19,147.48,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus","other molecular function","TRRAP","ENSG00000196367","Rett syndrome causing genes","Ub-specific processing proteases; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex","Human T-cell leukemia virus 1 infection",2361.1,2029.2,2407.6,2393.3,2543,2515,0.912310603518849,-0.13240300967828134,0.16327673635608006,0.7870756890655702,0.39964412459820475,0.39832656746411593,3190]
["High","Q9Y4A8","nuclear factor erythroid 2-related factor 3 [OS=Homo sapiens]",2,1,1,1,694,76.1,5.44,3.21,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFE2L3","ENSG00000050344","","","",26.5,24.9,33.3,41.2,41,44.2,0.6700949367088607,-0.5775625888449045,0.007445609238011554,2.128099760251458,0.09346513975947622,1.0293503402836413,622]
["High","Q9Y4B4","Helicase ARIP4 [OS=Homo sapiens]",11,12,19,12,1467,162.7,6.09,39.73,"cell organization and biogenesis","nucleus","nucleic acid binding activity;other molecular function","RAD54L2","ENSG00000164080","","","",816.1,755.6,861.7,869.2,745.7,782,1.0152280028369978,0.021803768417834466,0.811730833764507,0.09058795695337027,0.894565187019516,0.04838800687821407,7085]
["High","Q9Y4B5","Microtubule cross-linking factor 1 [OS=Homo sapiens]",4,6,8,3,1905,209.4,6.43,15.27,"cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MTCL1","ENSG00000168502","","","",67.9,55.1,70,73.5,69.3,67.8,0.916429249762583,-0.12590458887027428,0.302301081224654,0.5195602995007764,0.5453712666825551,0.263307746940654,4328]
["High","Q9Y4B6","DDB1- and CUL4-associated factor 1 [OS=Homo sapiens]",14,17,28,17,1507,168.9,5.06,41.4,"protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","DCAF1","ENSG00000145041","Hippo-Merlin signaling dysregulation","Antigen processing: Ubiquitination & Proteasome degradation","Human immunodeficiency virus 1 infection",818.1,773,842.4,900.9,898,923.8,0.8937819076651853,-0.16200525353986664,0.011689266932968,1.9322127238210085,0.11656423526515215,0.9334346812203166,783]
["High","Q9Y4C1","Lysine-specific demethylase 3A [OS=Homo sapiens]",18,18,28,17,1321,147.2,8.07,66.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3A","ENSG00000115548","Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; HDMs demethylate histones","Thermogenesis",761.6,626.6,742.4,598.2,525.1,631.9,1.2138787602552414,0.27962433533893477,0.07624746982363191,1.1177745632581149,0.277936622027506,0.5560542250953162,2142]
["High","Q9Y4C2-1","TRPM8 channel-associated factor 1 [OS=Homo sapiens]",17,10,38,10,921,102.1,6.54,88.55,"other biological processes","plasma membrane;other membranes","other molecular function","TCAF1","ENSG00000198420","","","",1467.4,1418.5,1342.5,637.2,642.7,658.5,2.1813867106892277,1.125245549959701,3.2238620188978364E-5,4.491623554247108,0.00968150563213627,2.0140570975592906,26]
["Medium","Q9Y4C4","Malignant fibrous histiocytoma-amplified sequence 1 [OS=Homo sapiens]",1,1,1,1,1052,116.9,7.88,0,"stress response;developmental processes;other biological processes","other cell component","other molecular function","MFHAS1","ENSG00000147324","","","",22.2,30.5,21.4,15.7,25.4,19.6,1.2207578253706757,0.28777702605015204,0.33199473173473165,0.47886880785225455,0.5727385915565145,0.24204355281232895,4526]
["High","Q9Y4C5-1","Carbohydrate sulfotransferase 2 [OS=Homo sapiens]",4,2,2,2,530,57.8,9.98,2.4,"other metabolic processes;stress response;developmental processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","CHST2; HEL-S-75","ENSG00000175040; ENSPTRG00000043559","Metapathway biotransformation Phase I and II","Keratan sulfate biosynthesis","Glycosaminoglycan biosynthesis",136.2,129.2,127.2,136.4,128.2,139.9,0.9705809641532754,-0.04307952985116916,0.41944676519668733,0.3773231505644643,0.6419130424648637,0.19252380017960014,5102]
["High","Q9Y4C8","Probable RNA-binding protein 19 [OS=Homo sapiens]",28,23,42,23,960,107.3,6.54,86.59,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","RBM19","ENSG00000122965","","","",2033.3,1704.6,1947.1,2064.6,2186.4,2178.4,0.8842193672815505,-0.17752376053312816,0.079242736005763,1.101040538033893,0.281623706296312,0.550330790295768,2197]
["High","Q9Y4D1","Disheveled-associated activator of morphogenesis 1 [OS=Homo sapiens]",9,10,10,10,1078,123.4,7.23,14.3,"cell-cell signaling;cell organization and biogenesis;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","DAAM1","ENSG00000100592","Physico-chemical features and toxicity-associated pathways; Wnt signaling","RHO GTPases Activate Formins; RHOA GTPase cycle; PCP/CE pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle","Wnt signaling pathway",396.1,337.8,412.4,327.9,312.6,333.4,1.1770202279494817,0.23513911435396095,0.07066663654411541,1.1507855789144097,0.26616743759597356,0.5748450763496352,2073]
["High","Q9Y4D8-1","Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",3,8,10,7,3996,439.1,6.19,14.21,"protein metabolism;other metabolic processes;other biological processes","other membranes","other molecular function","HECTD4","","","","",121,129.9,124.9,118.8,132,135.7,0.9723156532988356,-0.04050334739215434,0.5679850077198447,0.24566312758206812,0.7416098562335364,0.12982450691184358,5980]
["High","Q9Y4E1","WASH complex subunit 2C [OS=Homo sapiens]",28,24,45,6,1318,144.6,4.79,72.31,"","","","","","","","",110.9,109,97.5,125.7,105.3,112.2,0.9248251748251749,-0.11274742466436356,0.304550053226279,0.5163413202608124,0.5475309269147562,0.261591344964406,4343]
["High","Q9Y4E5","E3 SUMO-protein ligase ZNF451 [OS=Homo sapiens]",14,13,18,13,1061,121.4,6.77,38.79,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","ZNF451","ENSG00000112200","","","",782.9,644.8,758.6,740.6,751.9,750.1,0.974895210915901,-0.036680939426745114,0.6830646246404748,0.16553820583963083,0.8166235781951963,0.08797808494175222,6531]
["High","Q9Y4E8","ubiquitin carboxyl-terminal hydrolase 15 [OS=Homo sapiens]",31,25,59,23,981,112.3,5.22,110.07,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","USP15","ENSG00000135655","","Ub-specific processing proteases; UCH proteinases; Downregulation of TGF-beta receptor signaling","Mitophagy",2410.6,2334.9,2389.1,2225,2109.2,2134.7,1.102907758660669,0.14131213663414396,0.006015376744176876,2.2207371675272474,0.08225579968219447,1.0848334711144598,571]
["High","Q9Y4F1","FERM, RhoGEF and pleckstrin domain-containing protein 1 [OS=Homo sapiens]",13,10,15,10,1045,118.6,8.15,31.63,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","FARP1","ENSG00000152767","","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOA GTPase cycle; RHOF GTPase cycle","",664,587.6,723.2,667.1,706.6,707.8,0.9487388902233965,-0.07591700828648398,0.4393769247281696,0.3571627551678394,0.6535825925466847,0.18469952327734462,5249]
["High","Q9Y4F5","Centrosomal protein of 170 kDa protein B [OS=Homo sapiens]",8,11,13,9,1589,171.6,6.84,26.46,"","cytoskeleton;other cell component","","CEP170B","ENSG00000099814","","","",426.4,439.1,420.2,407.6,340.8,384.2,1.1351757019247748,0.18291561441262122,0.06616759502607851,1.1793546502420695,0.25716106618398255,0.5897947823316834,2009]
["High","Q9Y4G6","Talin-2 [OS=Homo sapiens]",34,72,166,53,2542,271.4,5.57,360.2,"cell adhesion;cell organization and biogenesis","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN2","ENSG00000171914","Focal adhesion","","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection",3974.1,3659,3989.4,3531,3380.1,3381.7,1.1291873931291778,0.17528492694705047,0.020242799353930013,1.6937294295842695,0.1513944227542965,0.8198901235918775,1044]
["High","Q9Y4G8","rap guanine nucleotide exchange factor 2 [OS=Homo sapiens]",4,4,6,3,1499,167.3,6.67,7.87,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RAPGEF2","ENSG00000109756","MAPK signaling pathway","RAF/MAP kinase cascade","MAPK signaling pathway; Rap1 signaling pathway; Tight junction",31.7,18.8,49.7,27,26.6,31.8,1.1733021077283372,0.230574533574718,0.6170776825741056,0.20966016013265965,0.7730053819250147,0.11181748236602283,6233]
["High","Q9Y4H2","Insulin receptor substrate 2 [OS=Homo sapiens]",6,7,8,7,1338,137.2,8.65,17,"other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","IRS2","ENSG00000185950","Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Nonalcoholic fatty liver disease; Insulin signaling; FOXA2 pathway; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways","PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF/MAP kinase cascade; Growth hormone receptor signaling; Interleukin-7 signaling; Signaling by Leptin; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); PI3K Cascade; PI3K/AKT activation; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; SOS-mediated signalling; IRS activation; Signal attenuation","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Alzheimer disease; MicroRNAs in cancer",503.4,565.8,454.2,369.9,342.7,333.3,1.4565446027344873,0.5425498807838577,0.009539909187558026,2.0204557594185624,0.1062590740890914,0.9736339727265857,701]
["High","Q9Y4I1-1","Unconventional myosin-Va [OS=Homo sapiens]",10,15,19,11,1855,215.3,8.48,27.22,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5A","ENSG00000197535","Joubert syndrome","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing","Pathogenic Escherichia coli infection",716.2,615.2,736.1,763.3,789.8,742.2,0.900753714111445,-0.15079539950466575,0.12963056026928743,0.8872926019241789,0.35576640231374207,0.44883506799663353,2845]
["High","Q9Y4I5","Tesmin [OS=Homo sapiens]",10,3,3,3,508,55,5.71,5.92,"other biological processes","nucleus;other cell component","other molecular function","TESMIN","ENSG00000132749","","","",46.3,59.5,50.7,72,52.6,59.8,0.8486984815618221,-0.23667599860935729,0.2469233463444569,0.6074378460371633,0.49587898360532906,0.30462429763276494,3888]
["High","Q9Y4K0","Lysyl oxidase homolog 2 [OS=Homo sapiens]",8,5,7,5,774,86.7,6.38,16.64,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","LOXL2","ENSG00000134013","Canonical and non-canonical TGF-B signaling","Crosslinking of collagen fibrils; Elastic fibre formation","",292.8,300.7,273.3,255.5,238.1,227.5,1.2020524199140201,0.26549981144094775,0.013558396421371513,1.8677916723075862,0.12483957459677922,0.9036477199056647,848]
["High","Q9Y4K3","TNF receptor-associated factor 6 [OS=Homo sapiens]",19,6,9,6,522,59.5,6.44,15.13,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TRAF6","ENSG00000175104","IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; T-cell receptor (TCR) signaling pathway; Toll-like receptor signaling pathway","Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; TRAF6 mediated NF-kB activation; Ovarian tumor domain proteases; TRAF6 mediated IRF7 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PIP3 activates AKT signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","MAPK signaling pathway; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; Autophagy; Endocytosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; Neurotrophin signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",102.7,117.6,108.5,109.7,98,103.3,1.057234726688103,0.08029571866371821,0.3413535411082419,0.4667955875368023,0.5816866977243895,0.23531086773154555,4582]
["High","Q9Y4K4","mitogen-activated protein kinase kinase kinase kinase 5 [OS=Homo sapiens]",12,7,15,7,846,95,7.64,13.31,"","","","","","","","",374.9,456.7,392,404.2,376.7,426.2,1.01366912434761,0.019586813523066484,0.8575209033171654,0.06675528459755296,0.9211065088871133,0.03569014879608622,7269]
["High","Q9Y4L1","Hypoxia up-regulated protein 1 [OS=Homo sapiens]",61,48,364,48,999,111.3,5.22,807.97,"stress response;transport;other biological processes","non-structural extracellular;ER/Golgi;other cell component","other molecular function","HYOU1","ENSG00000149428; ENSG00000280682","VEGFA-VEGFR2 signaling pathway","XBP1(S) activates chaperone genes; Scavenging by Class F Receptors","Protein processing in endoplasmic reticulum",14932,12242.1,13732,13883.8,12869.7,13655.9,1.0122916945067235,0.017625066298419534,0.8527454407083219,0.06918059391471411,0.9183774346276659,0.03697879582707241,7250]
["High","Q9Y4L5","E3 ubiquitin-protein ligase RNF115 [OS=Homo sapiens]",11,2,2,2,304,33.7,5.69,6.65,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","RNF115","ENSG00000265491","","Antigen processing: Ubiquitination & Proteasome degradation","",51.8,56,65.1,66.8,61.9,69.2,0.8736735725113695,-0.1948337434052302,0.13602900970440235,0.8663684636074621,0.36523882660659335,0.43742306113582696,2908]
["High","Q9Y4P1-1","Cysteine protease ATG4B [OS=Homo sapiens]",27,7,28,7,393,44.3,5.07,63.67,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol","other molecular function","ATG4B","ENSG00000168397","","Macroautophagy","Autophagy; Autophagy",482.7,389.9,561.4,531.7,520.4,508.7,0.9187596104561764,-0.12224065901975918,0.44557838102210245,0.35107588881855933,0.656677236508225,0.18264803812113617,5298]
["High","Q9Y4P3","Transducin beta-like protein 2 [OS=Homo sapiens]",25,12,21,12,447,49.8,9.44,35.73,"stress response;signal transduction","other membranes;ER/Golgi","other molecular function","TBL2","ENSG00000106638","7q11.23 copy number variation syndrome","","",865.8,719.5,852.6,924.1,965.3,907.2,0.8717371093470642,-0.19803496931648737,0.07430566632148389,1.1289780670157066,0.2734112359274959,0.5631836419223931,2122]
["High","Q9Y4P8-1","WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",23,6,9,1,454,49.4,6.46,22.96,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","WIPI2","ENSG00000157954","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease","Macroautophagy","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis",363.6,275.9,380.3,308.3,393.9,358.8,0.9611687087653157,-0.05713841317356791,0.7533973507613465,0.12297591127869137,0.8583870589150143,0.06631683843745066,6853]
["High","Q9Y4P8-6","Isoform 6 of WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",24,6,9,1,443,48.2,6.3,21.67,"","","","WIPI2","","","","",38.3,21.5,26.2,23.6,25,23.5,1.1927877947295424,0.25433740034863794,0.4088913737878112,0.3883920514800741,0.6349689432249861,0.19724751583535882,5028]
["High","Q9Y4R8","telomere length regulation protein TEL2 homolog [OS=Homo sapiens]",23,15,27,15,837,91.7,5.76,55.26,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TELO2","ENSG00000100726","Fragile X syndrome; Malignant pleural mesothelioma","","Fanconi anemia pathway; mTOR signaling pathway",631.4,832.2,711.8,716.4,715.8,763.1,0.9909351797020909,-0.013137405771124887,0.9178590629625754,0.03722399949228617,0.9549158645718573,0.020034891412939928,7505]
["Low","Q9Y4U1","Methylmalonic aciduria and homocystinuria type C protein [OS=Homo sapiens]",3,1,1,1,282,31.7,7.81,0,"other metabolic processes","cytosol;other cell component","other molecular function","MMACHC","ENSG00000132763","","Cobalamin (Cbl, vitamin B12) transport and metabolism; Defective MMADHC causes MMAHCD; Defective MMACHC causes MAHCC","Vitamin digestion and absorption",22.8,20.8,28.9,25.4,32.7,26.6,0.8559622195985832,-0.22438097442990185,0.28818406391701856,0.5403300385957868,0.5323258034218313,0.27382248176617024,4227]
["High","Q9Y4W2","Ribosomal biogenesis protein LAS1L [OS=Homo sapiens]",44,25,55,25,734,83,4.73,103.69,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LAS1L","ENSG00000001497","","Major pathway of rRNA processing in the nucleolus and cytosol","",2342.1,2212,2410,2581.5,2608.2,2526.7,0.902506350111451,-0.1479910119268118,0.016264598775761387,1.7887566456696813,0.13669966333815384,0.8642325550046875,929]
["High","Q9Y4W6","AFG3-like protein 2 [OS=Homo sapiens]",29,22,59,21,797,88.5,8.66,131.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","AFG3L2","ENSG00000141385","Ciliary landscape","Processing of SMDT1","Spinocerebellar ataxia",2851.6,2828.5,3109.9,2966.1,3029.5,3013.7,0.9756584862308948,-0.03555185124056391,0.4721868000511582,0.32588615775934765,0.6758633427680005,0.17014110802507298,5455]
["High","Q9Y4X0","AMME syndrome candidate gene 1 protein [OS=Homo sapiens]",10,3,4,2,333,35.4,8.63,6.99,"","mitochondrion;nucleus","","AMMECR1","ENSG00000101935","","","",138.7,109.7,118.7,132,161.2,138.8,0.8497685185185184,-0.23485819795128368,0.15339666250338452,0.814184089357908,0.38462464381066996,0.4149628929313741,3114]
["High","Q9Y4X5","E3 ubiquitin-protein ligase ARIH1 [OS=Homo sapiens]",37,15,42,15,557,64.1,5.08,85.92,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ARIH1","ENSG00000166233","","ISG15 antiviral mechanism","",1490.5,1685.3,1475.6,1428.7,1398.7,1422.7,1.0944213077339355,0.13016822402689912,0.1212518351360036,0.9163116796666579,0.3471706376024628,0.45945701294965247,2727]
["High","Q9Y4Y9","U6 snRNA-associated Sm-like protein LSm5 [OS=Homo sapiens]",32,2,2,2,91,9.9,4.54,0,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM5","ENSG00000106355","","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",108.5,94.4,103.9,124.7,116.7,117.9,0.8538825494016142,-0.2278904524992308,0.02246307375667625,1.6485308168979447,0.15659971418940014,0.8052090349094909,1120]
["Low","Q9Y4Z0","U6 snRNA-associated Sm-like protein LSm4 [OS=Homo sapiens]",5,1,1,1,139,15.3,9.99,2.19,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM4","ENSG00000130520","Ciliary landscape","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",113.3,110.8,115.9,149.4,113.4,115.5,0.8987575997885275,-0.15399603002431206,0.3386423407924942,0.4702587425562821,0.579215640067425,0.2371597197679644,4565]
["High","Q9Y508-1","E3 ubiquitin-protein ligase RNF114 [OS=Homo sapiens]",27,5,13,5,228,25.7,7.25,31.58,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","RNF114","ENSG00000124226; ENSPPAG00000043607; ENSPTRG00000013613","","Antigen processing: Ubiquitination & Proteasome degradation","",497,516.8,447.4,498.8,443.6,454.7,1.0458807529883327,0.06471837082053371,0.46761537743991993,0.3301112155865578,0.6726493859710565,0.1722112499156219,5428]
["High","Q9Y512","sorting and assembly machinery component 50 homolog [OS=Homo sapiens]",33,13,45,13,469,51.9,6.9,78.11,"cell organization and biogenesis;transport","other membranes;mitochondrion","","SAMM50","ENSG00000100347","","RAC2 GTPase cycle; Mitochondrial protein import; Cristae formation","",1200.4,882,1288.4,1199.6,1360,1327.4,0.867198353485979,-0.2055660773790049,0.2647724422191587,0.577127218684611,0.5100772832092748,0.2923640177676687,4053]
["High","Q9Y520","Protein Prrc2c [OS=Homo sapiens]",27,63,184,62,2896,316.7,9.13,350.47,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;other cell component","other molecular function","PRRC2C","ENSG00000117523","VEGFA-VEGFR2 signaling pathway","","",9979.7,9022.2,8856.8,10781.8,8622.3,9147.1,0.9757453276920061,-0.03542344548007744,0.7702164345951491,0.11338721879841254,0.8694303775218916,0.06076518981845815,6917]
["High","Q9Y530","O-acetyl-ADP-ribose deacetylase 1 [OS=Homo sapiens]",14,2,3,2,152,17,8.31,5.34,"protein metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","OARD1","ENSG00000124596","","","",97,132.9,128,140.1,130.6,140.8,0.8697448359659782,-0.20133588689260373,0.20179284024123315,0.6950942469142035,0.4435806578275756,0.3530273993621315,3552]
["High","Q9Y535","DNA-directed RNA polymerase III subunit RPC8 [OS=Homo sapiens]",27,3,4,3,204,22.9,4.58,7.21,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR3H","ENSG00000100413","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",114.9,100.4,92,114.3,113.2,109.1,0.9129530600118836,-0.13138740973698668,0.22835330001927215,0.64139270785902,0.473316317109232,0.3248485234036522,3767]
["High","Q9Y546","Leucine-rich repeat-containing protein 42 [OS=Homo sapiens]",7,3,3,3,428,48.5,7.46,8.42,"","","","LRRC42","ENSG00000116212","","","",163,179.4,182,273.3,275.9,285.6,{"$f":"AVERAGE(T7682:V7682)/AVERAGE(W7682:Y7682)","v":0.6281744130330617},{"$f":"LOG(Z7682,2)","v":-0.6707629149380809},{"$f":"TTEST(T7682:V7682,W7682:Y7682,2,2)","v":1.2383189641193223E-4},{"$f":"-LOG10(AB7682)","v":3.9071674760630906},{"$f":"AB7682*7808/AF7682","v":0.01559482979329624},{"$f":"-LOG10(AD7682)","v":1.807019360902709},62]
["High","Q9Y547","Intraflagellar transport protein 25 homolog [OS=Homo sapiens]",42,4,11,4,144,16.3,5.03,29.53,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","HSPB11","ENSG00000081870","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis","Intraflagellar transport","",175.3,160,205,219.1,238.6,225.9,0.790374488004681,-0.3393917150487073,0.029414368566933507,1.531440470099579,0.17707585949931906,0.7518406415250237,1297]
["High","Q9Y548","Protein YIPF1 [OS=Homo sapiens]",6,2,4,2,306,34.3,5.31,12.28,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","YIPF1","ENSG00000058799","","","",263.7,165.5,279.1,247.6,253.3,268,0.9211861100273117,-0.11843543706293506,0.6055745732696782,0.2178323681851589,0.7678347301217356,0.11473224809370274,6158]
["High","Q9Y570","Protein phosphatase methylesterase 1 [OS=Homo sapiens]",41,14,44,14,386,42.3,5.97,87.1,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","nucleus","enzyme regulator activity;other molecular function","PPME1","ENSG00000214517","","Cyclin A/B1/B2 associated events during G2/M transition","",1689,1392.5,1773.3,1649.5,1713.7,1695.1,0.9597690923828165,-0.05924074045380449,0.5932806447703434,0.2267398198852854,0.7595237373941369,0.11945864858435105,6099]
["High","Q9Y573-1","actin-binding protein IPP [OS=Homo sapiens]",3,2,2,2,584,65.2,5.73,2.39,"","cytoskeleton;other cell component","cytoskeletal activity","IPP","ENSG00000197429; ENSPPAG00000037424","","","",111.2,90.4,110.3,116,122.5,120.1,0.8697713329615171,-0.20129193549422267,0.09178047379116827,1.037249704711104,0.3028833217926635,0.5187246403443802,2366]
["High","Q9Y575","Ankyrin repeat and SOCS box protein 3 [OS=Homo sapiens]",2,1,3,1,518,57.7,6.27,5.21,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","","ASB3","ENSG00000115239","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",24.1,22.1,24.1,27.5,27.2,38.4,0.7551020408163267,-0.4052564784862581,0.11223612668279222,0.9498673294112334,0.3343531770847927,0.47579454569919855,2621]
["High","Q9Y576","Ankyrin repeat and SOCS box protein 1 [OS=Homo sapiens]",3,1,1,1,335,37,8.21,2.49,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","","ASB1","ENSG00000065802","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",44,30.5,58.2,47.8,74.7,63.4,0.7138246369015598,-0.48635839954928856,0.18757283579719755,0.7268300557095024,0.42748648625350805,0.3690776096803587,3426]
["High","Q9Y580","RNA-binding protein 7 [OS=Homo sapiens]",6,2,4,2,266,30.5,9.57,11.13,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RBM7","ENSG00000076053","","","",394,297,399.6,558.4,461.2,491.5,0.7217258950433458,-0.4704770762600693,0.03329863222522796,1.4775736052094681,0.18651055983829262,0.7292965743128234,1394]
["High","Q9Y587-1","AP-4 complex subunit sigma-1 [OS=Homo sapiens]",7,1,3,1,144,17,5.19,5.1,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","AP4S1","ENSCANG00000008358; ENSCATG00000035780; ENSG00000100478; ENSGGOG00000003198; ENSMMUG00000003123; ENSPANG00000017427; ENSPCOG00000016646; ENSPPAG00000041450; ENSPTRG00000006239; ENSRROG00000019504","","Lysosome Vesicle Biogenesis","Lysosome",68,54.8,65.8,67.1,83.9,66.4,0.8675252989880404,-0.20502226435221269,0.24370808169063052,0.6131300687822465,0.4924618793582927,0.30762738186706684,3864]
["High","Q9Y592","Centrosomal protein of 83 kDa [OS=Homo sapiens]",2,2,4,2,693,82,6.28,6.88,"","","","","","","","",49.9,33.6,50.7,52.9,53.6,45.4,0.8834759710335746,-0.17873719830190016,0.3923118838590184,0.40636853608095347,0.6207033817976121,0.20711588842797357,4935]
["High","Q9Y597","BTB/POZ domain-containing protein KCTD3 [OS=Homo sapiens]",9,6,8,6,815,88.9,7.03,12.51,"cell organization and biogenesis","plasma membrane;other membranes","","KCTD3","ENSG00000136636","","CDC42 GTPase cycle","",281.7,260.1,259.8,301.3,265.5,252.1,0.9788740994016364,-0.030804779337475156,0.7425267873565675,0.12928787414368884,0.8533484185575625,0.06887361201906256,6794]
["High","Q9Y5A7","NEDD8 ultimate buster 1 [OS=Homo sapiens]",24,16,25,16,615,70.5,5.96,60.75,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","","NUB1","ENSG00000013374","","","",1447,1183,1436.2,1196,1184,1180.8,1.1419343967647717,0.19147977138312716,0.12291636164167791,0.9103903034622606,0.34835969208646866,0.457972101991429,2755]
["High","Q9Y5A9-1","YTH domain-containing family protein 2 [OS=Homo sapiens]",18,10,41,7,579,62.3,8.79,79.38,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity","YTHDF2","ENSCSAG00000001018; ENSG00000198492; ENSMFAG00000026128; ENSMMUG00000011391; ENSMNEG00000041161; ENSNLEG00000009856; ENSPTRG00000000439; ENSRBIG00000043898; ENSRROG00000038863","","","",1654.4,1617.4,1625.8,2101.9,2112.3,2144.3,0.7702445545333018,-0.37661151713662283,8.7903264346251487E-6,5.055994996812004,0.007626096533505907,2.117697701592693,9]
["High","Q9Y5B0","RNA polymerase II subunit A C-terminal domain phosphatase [OS=Homo sapiens]",25,19,43,19,961,104.3,5.27,78.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CTDP1","ENSG00000060069","","TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1843.6,1833,1817.4,1681.5,1655.2,1709.4,1.0887616178831174,0.12268811351799287,1.0134587105719915E-3,2.994193940247756,0.03841303695216558,1.415521355958274,206]
["High","Q9Y5B6","PAX3- and PAX7-binding protein 1 [OS=Homo sapiens]",15,12,23,12,917,104.7,5.68,46.07,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity","PAXBP1","ENSG00000159086; ENSG00000263141","","","",1058.1,1087.6,1083.3,1193.4,1133.5,1173.7,0.9224133005770437,-0.11651477905921545,0.01039128959213669,1.9833305517696131,0.11038801242912011,0.9570780861951725,735]
["High","Q9Y5B8","Nucleoside diphosphate kinase 7 [OS=Homo sapiens]",15,4,8,4,376,42.5,6.47,11.18,"other metabolic processes","cytosol;cytoskeleton","kinase activity;other molecular function","NME7","ENSG00000143156","Pyrimidine metabolism; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",186.1,173.1,220.5,210.4,220.5,224.9,0.8839585239402258,-0.17794941611854878,0.1611951945717748,0.7926479091938852,0.39716379905850985,0.40103034372555024,3169]
["High","Q9Y5B9","FACT complex subunit SPT16 [OS=Homo sapiens]",44,50,246,50,1047,119.8,5.66,516.81,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","SUPT16H","ENSG00000092201","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation","",11916.6,9974.6,12002.2,11567.9,12787.2,12232.8,0.9263554344469075,-0.11036224575815286,0.2972230465633184,0.5269175185749243,0.5415910262698693,0.2663285401755058,4285]
["Medium","Q9Y5E1","Protocadherin beta-9 [OS=Homo sapiens]",1,1,1,1,797,87,5.02,2.2,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;other cell component","other molecular function","PCDHB9","ENSG00000177839","","","",67.3,76.5,80.4,79.9,97.1,85.3,0.8547464735036218,-0.22643152945955755,0.11792094192679364,0.9284090604214634,0.34164256570107787,0.46642802528558547,2695]
["Low","Q9Y5F9-1","Protocadherin gamma-B6 [OS=Homo sapiens]",1,1,1,1,930,101,5.26,0,"cell adhesion","plasma membrane;other membranes","other molecular function","PCDHGB6","ENSG00000253305","","","",96.2,100.5,97.6,91.1,89.9,101.3,1.0425079702444204,0.06005841349070142,0.3554758563272188,0.4491898909115325,0.592055351152501,0.2276376892629313,4688]
["High","Q9Y5J1","U3 small nucleolar RNA-associated protein 18 homolog [OS=Homo sapiens]",25,11,31,11,556,62,8.76,68.25,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","UTP18","ENSG00000011260","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1424,1399.6,1311.7,1768.2,1663.6,1761.5,0.7962759709625864,-0.32865957248809263,1.8300477662007374E-3,2.737537574571936,0.04876796231568381,1.31186539026741,293]
["High","Q9Y5K3","Choline-phosphate cytidylyltransferase B [OS=Homo sapiens]",26,8,15,5,369,41.9,6.4,29.65,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PCYT1B","ENSG00000102230","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways","Synthesis of PC","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer",224.2,239.5,208.6,263.8,235.4,233.1,0.9180663662433428,-0.1233296462707607,0.20722718951082747,0.6835532630203108,0.44957763148111723,0.3471953050145867,3599]
["High","Q9Y5K5-1","Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",58,14,68,1,329,37.6,5.33,154.39,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UCHL5","ENSCANG00000036448; ENSCATG00000035323; ENSG00000116750; ENSGGOG00000004347; ENSMFAG00000038349; ENSMLEG00000030039; ENSMNEG00000039813; ENSPPAG00000029294; ENSPTRG00000001793","TGF-beta signaling pathway","UCH proteinases; Downregulation of TGF-beta receptor signaling","",28.8,31.8,25.4,27.8,24.5,24.5,1.1197916666666667,0.1632303488683042,0.22713666826626003,0.6437127489145654,0.47179651657966437,0.32624526996974246,3759]
["High","Q9Y5K5-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",58,14,68,1,328,37.5,5.4,158.34,"","","","UCHL5","","","","",2664.2,2401.3,2768.9,2561.5,2820.3,2630,0.9778576599515715,-0.0323036176722241,0.6817524686604,0.16637328078105448,0.8154294232996941,0.08861362186822379,6528]
["High","Q9Y5K6","CD2-associated protein [OS=Homo sapiens]",40,21,42,21,639,71.4,6.4,76.66,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CD2AP","ENSG00000198087","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis","Nephrin family interactions","Bacterial invasion of epithelial cells",2031.2,1833.2,1987.4,2280.5,2116.2,2175.8,0.8903461392164321,-0.16756177426010227,0.03537248561912626,1.451334421306483,0.19021237445877262,0.7207612330119224,1452]
["High","Q9Y5K8","V-type proton ATPase subunit D [OS=Homo sapiens]",47,12,31,12,247,28.2,9.36,54.53,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol","transporter activity","ATP6V1D","ENSG00000100554","Proximal tubule transport","Amino acids regulate mTORC1; Neutrophil degranulation; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",882,581.4,829.6,727.5,756.9,763.2,1.0201993237230822,0.028851049503953972,0.8790878709186631,0.05596771201637508,0.9322175874144943,0.03048270783444132,7363]
["High","Q9Y5L0-2","transportin-3 [OS=Homo sapiens]",34,23,66,23,923,104.1,5.57,160,"transport","other membranes;nucleus;other cell component","other molecular function","TNPO3","ENSCANG00000033070; ENSCATG00000030018; ENSG00000064419; ENSGGOG00000008339; ENSMLEG00000037881; ENSMMUG00000004311; ENSMNEG00000045277; ENSPPAG00000034975; ENSPPYG00000017990; ENSPTRG00000019676","","","Nucleocytoplasmic transport",2490.7,2389.9,2473.1,2543.6,2540.7,2587.5,0.9585364581975548,-0.061094788648074584,0.03741277659647344,1.426980059356481,0.19397009273921956,0.7122652265625273,1506]
["High","Q9Y5M8","signal recognition particle receptor subunit beta [OS=Homo sapiens]",30,7,22,7,271,29.7,9.04,48.58,"transport","other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SRPRB","ENSG00000144867","","SRP-dependent cotranslational protein targeting to membrane; XBP1(S) activates chaperone genes","Protein export",941.1,943.8,1009.4,908.9,1032.3,994.4,0.985931325793705,-0.020440934478195415,0.7637437299365344,0.11705234213746388,0.8653767295522363,0.06279478739351699,6891]
["Low","Q9Y5N1","histamine H3 receptor [OS=Homo sapiens]",2,1,1,1,445,48.6,9.29,2.08,"cell-cell signaling;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","HRH3","ENSG00000101180","GPCRs, class A rhodopsin-like; Monoamine transport","Histamine receptors","Neuroactive ligand-receptor interaction",94.9,99.9,106.8,90.6,84.3,108.4,1.064595834804095,0.09030582689056618,0.488169258194497,0.3114295731713198,0.6890140216888345,0.1617719399499574,5532]
["High","Q9Y5N5","HemK methyltransferase family member 2 [OS=Homo sapiens]",24,5,9,5,214,22.9,5.11,15.88,"protein metabolism;DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","N6AMT1","ENSG00000156239","","Eukaryotic Translation Termination; Methylation","",435.9,432.1,483.1,427.1,470.6,431,1.0168585835779331,0.024119054852312426,0.745855541457184,0.12734527926080697,0.8540313928285221,0.06852616504680485,6819]
["High","Q9Y5N6","Origin recognition complex subunit 6 [OS=Homo sapiens]",41,8,12,8,252,28.1,8.66,17.75,"DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC6","ENSG00000091651","Cell cycle; G1 to S cell cycle control; DNA replication","Assembly of the ORC complex at the origin of replication; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDT1 association with the CDC6:ORC:origin complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle",603.8,522.2,607.3,528.6,532.4,510.3,1.103099344491822,0.14156272506498713,0.13230471684427095,0.8784246723436968,0.35956673481380697,0.44422049367700894,2873]
["High","Q9Y5P4-1","Collagen type IV alpha-3-binding protein [OS=Homo sapiens]",24,14,39,14,624,70.8,5.48,67.26,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus","transporter activity;kinase activity;other molecular function","CERT1","ENSG00000113163; ENSPTRG00000016996","Sphingolipid pathway","","",1360.4,1226.8,1337.7,1320.5,1208.4,1291.2,1.0274338368105547,0.03904549232188011,0.5472671760363479,0.2618005991693542,0.7274535428144032,0.13819473669750024,5874]
["High","Q9Y5P6","Mannose-1-phosphate guanyltransferase beta [OS=Homo sapiens]",20,5,17,5,360,39.8,6.61,37.01,"other metabolic processes","other cell component","other molecular function","GMPPB","ENSG00000173540","","Synthesis of GDP-mannose","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",362.8,372.7,381.5,353.3,330.4,344.5,1.0863645205212993,0.11950826862035026,0.02607907781180752,1.5837077698543924,0.16786928240279728,0.7750287660623302,1213]
["High","Q9Y5Q0","fatty acid desaturase 3 [OS=Homo sapiens]",16,5,7,4,445,51.1,7.77,15.7,"other metabolic processes","other membranes;ER/Golgi","other molecular function","FADS3","ENSG00000221968","","","",122.2,115.5,128.1,146.8,142.1,137.4,0.8580811634998827,-0.22081398021522,0.011316007469089881,1.9463067745604472,0.11534645733505716,0.9379957395344157,766]
["High","Q9Y5Q8-1","general transcription factor 3C polypeptide 5 [OS=Homo sapiens]",30,13,22,13,519,59.5,6.9,44.41,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity","GTF3C5","ENSG00000148308","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",984.5,916.9,950,1020.8,1073.9,1013,0.9175274318627926,-0.12417680317587533,0.03532227988025179,1.4519512726069905,0.1905987293054637,0.7198799990673926,1447]
["High","Q9Y5Q9","General transcription factor 3C polypeptide 3 [OS=Homo sapiens]",24,14,47,14,886,101.2,5.07,80.98,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","nucleic acid binding activity","GTF3C3","ENSG00000119041","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1354.1,1755.4,1332.8,1504,1574.9,1528.6,0.964145415084102,-0.052677340756416995,0.712241096422784,0.14737297107918104,0.835262613527951,0.07817695724119421,6658]
["Medium","Q9Y5R2","Matrix metalloproteinase-24 [OS=Homo sapiens]",2,1,1,1,645,73.2,9.23,0,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","MMP24","ENSG00000125966","Matrix metalloproteinases","Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action",25.9,10.6,37.4,29,51.9,42,0.6013018714401953,-0.7338386462265106,0.18486945920700973,0.7331348292053623,0.4244224456008033,0.3722016564794491,3401]
["High","Q9Y5S2","Serine/threonine-protein kinase MRCK beta [OS=Homo sapiens]",16,25,42,23,1711,194.2,6.37,97.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPB","ENSG00000198752","VEGFA-VEGFR2 signaling pathway","CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle","",1812.7,1546.2,1944.3,1840.5,1934.7,1872.1,0.9390682272944594,-0.09069811527927991,0.39445091699970003,0.40400702997642374,0.6230776370490912,0.20545783577856508,4943]
["High","Q9Y5S9","RNA-binding protein 8A [OS=Homo sapiens]",48,8,62,2,174,19.9,5.72,123.74,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","RBM8A","ENSG00000265241","","mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",1899.9,1866.4,1895.8,2680.6,1785.4,1554.8,0.9404231995748074,-0.08861796519174664,0.7453314769764589,0.1276505371777513,0.8539322336364183,0.06857659268980822,6815]
["High","Q9Y5S9-2","Isoform 2 of RNA-binding protein 8A [OS=Homo sapiens]",47,7,53,1,173,19.7,5.92,108.93,"","","","RBM8A","","","","",136.7,160.8,138.3,202.2,142.5,124.9,0.928023850085179,-0.10776621199414518,0.6713670045379836,0.1730400066971895,0.8094554619259691,0.09180704211989024,6476]
["High","Q9Y5T5-1","ubiquitin carboxyl-terminal hydrolase 16 [OS=Homo sapiens]",12,6,11,6,823,93.5,6.93,26.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","USP16","ENSG00000156256","","Ub-specific processing proteases","",186.8,196.5,186.9,199.1,200.8,192.6,0.9623628691983124,-0.05534711473503093,0.14206154423176642,0.8475234687876447,0.3717213597056408,0.42978248292964055,2984]
["High","Q9Y5U2-1","Protein TSSC4 [OS=Homo sapiens]",7,3,5,3,329,34.3,5.19,2.98,"","","","TSSC4","ENSG00000184281","","","",61.8,42.4,47.2,59.9,57.3,52.9,0.8900646678424456,-0.16801793567765333,0.3702795463975708,0.4314702769648787,0.6032010636912649,0.21953790129803122,4793]
["High","Q9Y5U9","immediate early response 3-interacting protein 1 [OS=Homo sapiens]",24,1,4,1,82,9,8.22,14.62,"transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","","IER3IP1","ENSG00000134049","","","",205.9,158.7,190.4,186.7,197.1,190.4,0.9665621734587253,-0.0490655590823509,0.6759724765611725,0.170070986781666,0.8131248031104044,0.0898427912541544,6491]
["High","Q9Y5V3","Melanoma-associated antigen D1 [OS=Homo sapiens]",15,10,29,7,778,86.1,5.83,61.46,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","MAGED1","ENSG00000179222","","NRAGE signals death through JNK; Caspase activation via Dependence Receptors in the absence of ligand","Neurotrophin signaling pathway",774,633.1,692.4,725.7,748.1,750.2,0.9440197841726619,-0.0831109998884904,0.37482532980805927,0.42617106820004824,0.6066824575334425,0.21703856267350774,4824]
["High","Q9Y5W7","Sorting nexin-14 [OS=Homo sapiens]",3,4,4,4,946,110.1,6.7,1.82,"cell organization and biogenesis;other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX14","ENSG00000135317","","","",105.3,99.7,126.2,128.2,137.6,114.3,0.8713496448303079,-0.19867635236264033,0.1964596385656797,0.7067266592767016,0.43777307589064696,0.3587509521141094,3504]
["High","Q9Y5W8","Sorting nexin-13 [OS=Homo sapiens]",3,3,3,3,968,112.1,6.58,7.79,"transport;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","SNX13","ENSG00000071189","","","",45.3,39.7,47.3,49.9,48.3,51.4,0.8843582887700535,-0.17729711360895986,0.07772550889164037,1.1094364258224638,0.28018502928251526,0.5525550734531299,2166]
["High","Q9Y5X1","Sorting nexin-9 [OS=Homo sapiens]",29,10,25,10,595,66.6,5.58,34.17,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","SNX9","ENSG00000130340","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","Salmonella infection",530.8,456.2,554.6,604.6,594.2,658.8,0.8298880275624462,-0.2690114005698454,0.042195606024015245,1.374732771286626,0.20501760537368452,0.6882088433913351,1607]
["High","Q9Y5X2","Sorting nexin-8 [OS=Homo sapiens]",13,6,12,6,465,52.5,7.39,32.15,"transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX8","ENSG00000106266","","","",350.5,280.9,391.6,383,411.7,396.1,0.8590863285186428,-0.21912498160534544,0.16887028625948086,0.7724467604277533,0.4062043114953871,0.39125547125933097,3246]
["High","Q9Y5X3","sorting nexin-5 [OS=Homo sapiens]",38,14,50,13,404,46.8,6.76,106.93,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","SNX5","ENSG00000089006","","Golgi Associated Vesicle Biogenesis","Endocytosis",1958.4,1329.4,1963.5,1809.2,1862.5,1835.6,0.9535162420786957,-0.06867058144968237,0.7067011451085017,0.1507642049723858,0.8320148584148344,0.0798689178559675,6632]
["High","Q9Y5Y0","Feline leukemia virus subgroup C receptor-related protein 1 [OS=Homo sapiens]",17,6,22,6,555,59.8,5.97,57.32,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion","transporter activity;other molecular function","FLVCR1","ENSG00000162769","","","",578.7,665.8,657.3,687.3,662.2,697.7,0.9289761625635014,-0.10628651721661851,0.17758340177844273,0.7505976289453744,0.41651282700092546,0.3803716194434064,3329]
["High","Q9Y5Y2","Cytosolic Fe-S cluster assembly factor NUBP2 [OS=Homo sapiens]",24,5,9,5,271,28.8,5.83,21.95,"cell organization and biogenesis;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NUBP2","ENSG00000095906","","Cytosolic iron-sulfur cluster assembly","",363.8,381.6,350.9,325.1,319.8,366.9,1.083514528562957,0.11571849828179716,0.17985178314207445,0.7450852520076918,0.4196899948515593,0.37707138397543205,3346]
["High","Q9Y5Z4-1","Heme-binding protein 2 [OS=Homo sapiens]",10,2,2,2,205,22.9,4.63,3.08,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","HEBP2","ENSG00000051620","","Neutrophil degranulation","",117.3,103.2,112.7,107.3,117.3,112.7,0.9878446486806997,-0.017643917652578958,0.8003833647297258,0.09670194637411093,0.888455119677239,0.05136450569639931,7034]
["Medium","Q9Y5Z6","Beta-1,3-galactosyltransferase 1 [OS=Homo sapiens]",3,1,1,1,326,38,9.29,2.12,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B3GALT1","ENSG00000172318","Ganglio sphingolipid metabolism; Metabolism of spingolipids in ER and Golgi apparatus","Lewis blood group biosynthesis","Glycosphingolipid biosynthesis; Metabolic pathways",24.3,32.7,36.4,18.2,27.2,22,1.3857566765578635,0.47067395852780347,0.12202144199745951,0.9135638470059885,0.3479705694361446,0.4584574861453242,2738]
["High","Q9Y5Z9-1","UbiA prenyltransferase domain-containing protein 1 [OS=Homo sapiens]",6,1,1,1,338,36.8,8.15,3.75,"other metabolic processes;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","UBIAD1","ENSG00000120942; ENSGGOG00000001270","7q11.23 copy number variation syndrome","Metabolism of vitamin K","",30.7,39.5,29.1,27.2,29.2,24.8,1.2229064039408868,0.29031399034319777,0.1574744695199856,0.802789845971778,0.3913305722508108,0.40745622201709714,3142]
["High","Q9Y605","MORF4 family-associated protein 1 [OS=Homo sapiens]",19,1,2,1,127,14.6,4.7,9.33,"","nucleus;other cell component","","MRFAP1","ENSG00000179010","","","",28,54.3,39,35.1,28.3,30.3,1.294557097118463,0.3724585974613232,0.30829525192153745,0.5110331638241076,0.5513443259283931,0.25857709053859257,4366]
["High","Q9Y606","tRNA pseudouridine synthase A [OS=Homo sapiens]",52,20,47,20,427,47.4,8.41,88.3,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","PUS1","ENSG00000177192","","","",1769,1682.8,1800,1641,1708,1671.4,1.0460919448649513,0.06500966092620417,0.1264450176576573,0.8980982785885859,0.3533581595815992,0.45178487570811365,2794]
["High","Q9Y608","Leucine-rich repeat flightless-interacting protein 2 [OS=Homo sapiens]",4,3,9,1,721,82.1,6.95,14.51,"cell-cell signaling;signal transduction;other biological processes","","other molecular function","LRRFIP2","ENSG00000093167","VEGFA-VEGFR2 signaling pathway","","",56.3,41.5,48.3,61.3,55.7,46.2,0.895220588235294,-0.15968487916799737,0.4058757369453412,0.3916069098201963,0.6324242175352672,0.19899150790403758,5011]
["High","Q9Y613","FH1/FH2 domain-containing protein 1 [OS=Homo sapiens]",28,19,40,19,1164,126.5,6.39,72.26,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FHOD1","ENSG00000135723","VEGFA-VEGFR2 signaling pathway","","Salmonella infection",571,569.1,555.7,597.5,559.5,549.2,0.9939045832844918,-0.008820737898338767,0.833525492037155,0.07908111343432979,0.9075675696313076,0.042121031277412214,7171]
["High","Q9Y617-1","phosphoserine aminotransferase [OS=Homo sapiens]",68,22,169,21,370,40.4,7.66,380.51,"other metabolic processes","cytosol;other cell component","other molecular function","PSAT1","ENSG00000135069; ENSGGOG00000015480; ENSPPAG00000036829; ENSPTRG00000021045","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Vitamin B6 metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors",8200.8,7125.4,8668.6,8565.1,9706.1,9361,0.8683637205868515,-0.2036286421065539,0.09977032817294273,1.0009985992614459,0.31449605263396724,0.5023848011886474,2477]
["High","Q9Y618-1","Nuclear receptor corepressor 2 [OS=Homo sapiens]",6,14,22,13,2525,274.6,7.59,28.1,"","","","","","","","",1070.8,888,994.2,1058.1,993.8,996.3,0.9687684535135491,-0.045776208282625123,0.6075100404193391,0.21644654001330219,0.768417041243188,0.11440301232177635,6173]
["High","Q9Y619","mitochondrial ornithine transporter 1 [OS=Homo sapiens]",5,2,3,2,301,32.7,9.13,6.35,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A15","ENSG00000102743","","Urea cycle","",199.6,186.3,203,229.2,238.8,242.1,0.8293198141106886,-0.2699995332684438,0.003216957215386267,2.492554715052403,0.061866999846640326,1.2085409439709613,406]
["High","Q9Y620-1","DNA repair and recombination protein RAD54B [OS=Homo sapiens]",2,2,3,2,910,102.9,8.12,4.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RAD54B","ENSG00000197275","Homologous recombination; DNA repair pathways, full network","","Homologous recombination",95,82.4,97.3,65.4,68,64.1,1.390886075949367,0.4760042571240285,0.005716055724323273,2.2429035460377955,0.08012740232588171,1.0962189365528892,557]
["High","Q9Y624","Junctional adhesion molecule A [OS=Homo sapiens]",51,12,53,12,299,32.6,7.9,98.69,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","F11R","ENSG00000158769","1q21.1 copy number variation syndrome","Integrin cell surface interactions; Tight junction interactions; Cell surface interactions at the vascular wall; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Epithelial cell signaling in Helicobacter pylori infection",2268.3,2353.1,2287.1,2514.6,2428,2476.9,0.9311274344632389,-0.10294946578562249,0.009015691881779635,2.0450009390570534,0.10367381769209924,0.9843309086789195,679]
["High","Q9Y625","Glypican-6 [OS=Homo sapiens]",9,3,3,2,555,62.7,5.41,9.71,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC6","ENSG00000183098","miR-509-3p alteration of YAP1/ECM axis","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","",14.9,12.4,14.3,16.3,14.6,12.4,0.9607390300230948,-0.05778349658563258,0.6977485793610837,0.156301039076193,0.8267103046511899,0.08264664901156747,6590]
["High","Q9Y639-1","Isoform 1 of Neuroplastin [OS=Homo sapiens]",33,8,26,8,282,31.3,6.87,63.74,"","","","NPTN","","","","",1331.3,1675.6,1482.1,1379,1220,1300.5,1.151173227336838,0.20310494503873147,0.1477607062359851,0.8304410418121418,0.37888853671283146,0.42148853412240056,3045]
["Medium","Q9Y646","Carboxypeptidase Q [OS=Homo sapiens]",1,1,1,1,472,51.9,6.18,2.19,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CPQ","ENSG00000104324","","","",29.4,20.5,34,38.3,33.6,44.3,{"$f":"AVERAGE(T7746:V7746)/AVERAGE(W7746:Y7746)","v":0.7220309810671257},{"$f":"LOG(Z7746,2)","v":-0.46986735296470555},{"$f":"TTEST(T7746:V7746,W7746:Y7746,2,2)","v":0.09897672287139266},{"$f":"-LOG10(AB7746)","v":1.004466929817974},{"$f":"AB7746*7808/AF7746","v":0.3136405244236338},{"$f":"-LOG10(AD7746)","v":0.5035678286517267},2464]
["High","Q9Y657","Spindlin-1 [OS=Homo sapiens]",47,10,30,9,262,29.6,6.96,54.87,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes","other membranes;cytosol;nucleus","other molecular function","SPIN1","ENSG00000106723","","","",848.2,941.2,811.4,998.3,1032.7,1008.6,0.8556388998552442,-0.22492602174330115,0.02154881043177142,1.6665766993861701,0.15450239839418844,0.8110647744833097,1089]
["High","Q9Y664","KICSTOR complex protein kaptin [OS=Homo sapiens]",11,4,6,4,436,48.1,5.26,6.99,"cell organization and biogenesis;stress response;other biological processes","other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity","KPTN","ENSG00000118162","","Amino acids regulate mTORC1","",70.2,99.8,77.7,59.1,76.4,80.7,1.1456984273820536,0.1962273455117128,0.3965169997397408,0.40173818858622906,0.624950491313665,0.20415438617741183,4954]
["High","Q9Y666","Solute carrier family 12 member 7 [OS=Homo sapiens]",14,11,16,11,1083,119,6.71,33.91,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC12A7","ENSG00000113504","","Cation-coupled Chloride cotransporters","Collecting duct acid secretion",526.5,618.3,500.7,511.7,480.6,491.9,1.1086780757310337,0.14884051431042258,0.21805535024445924,0.6614332529339653,0.46065372692335976,0.3366254108233989,3696]
["High","Q9Y672","Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",6,3,9,3,507,58.1,8.46,18.36,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG6","ENSG00000088035","GPCRs, other","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG6 causes CDG-1c","N-Glycan biosynthesis; Metabolic pathways",366,279.3,397.6,391.7,400.8,428.1,0.8544158610519419,-0.2269896659698238,0.184804248627853,0.733288048622286,0.4243975215547871,0.37222716100590575,3400]
["High","Q9Y673","dolichyl-phosphate beta-glucosyltransferase [OS=Homo sapiens]",17,4,5,4,324,36.9,9.28,10.28,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ALG5","ENSG00000120697","","Synthesis of dolichyl-phosphate-glucose","N-Glycan biosynthesis; Metabolic pathways",122.9,125,151.9,129.2,128.2,124.9,1.0457755689249282,0.06457327190997904,0.5695272384777337,0.24448550031589303,0.7423820831442646,0.12937251804656896,5990]
["High","Q9Y676","28S ribosomal protein S18b, mitochondrial [OS=Homo sapiens]",7,1,1,1,258,29.4,9.38,3.86,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPS18B","ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Viral carcinogenesis",20.4,25.7,25,39.2,24,23.9,0.8163030998851895,-0.29282315897944927,0.3751050571377473,0.42584708068475385,0.6067578798698012,0.21698457484481048,4827]
["High","Q9Y678","Coatomer subunit gamma-1 [OS=Homo sapiens]",57,37,115,33,874,97.7,5.47,252.96,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","COPG1","ENSG00000181789","VEGFA-VEGFR2 signaling pathway","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",3828.6,3391.9,3943.8,3756.8,4107.5,3986.9,0.9420396246793572,-0.08614035020205855,0.3098945264363261,0.5087860944915756,0.5529379484494593,0.25732360315831465,4376]
["High","Q9Y679-1","Ancient ubiquitous protein 1 [OS=Homo sapiens]",11,6,16,6,476,53,8.09,37.45,"","","","","","","","",678.8,612.3,724.5,734.7,740.9,681.9,0.9342294322132098,-0.09815119798392696,0.276498281768465,0.5583075631686604,0.5236232316391402,0.2809810933113835,4123]
["High","Q9Y692-1","Glucocorticoid modulatory element-binding protein 1 [OS=Homo sapiens]",17,8,12,7,573,62.6,4.83,30.46,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GMEB1","ENSG00000162419; ENSGGOG00000009221; ENSPPAG00000038756","","","",613,496.6,563.2,760.2,691.1,769.5,0.7532420749279538,-0.4088145059886818,0.011982304736942147,1.92145963952036,0.11842763972916999,0.926546926152166,790]
["High","Q9Y696","Chloride intracellular channel protein 4 [OS=Homo sapiens]",74,15,177,14,253,28.8,5.59,365.42,"transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","transporter activity","CLIC4","ENSG00000169504","","","",6060.1,5840,6198.5,6314.1,5928.9,5654.4,1.011241856359024,0.016128084521499685,0.7736573183712724,0.11145136192117684,0.8710477782037339,0.05995802267184512,6935]
["High","Q9Y697","Cysteine desulfurase, mitochondrial [OS=Homo sapiens]",32,10,16,10,457,50.2,8.31,38.46,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","NFS1","ENSG00000244005","","","Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system",449.3,477.5,468.4,447.5,415.2,444.5,1.0673194614443082,0.09399205663124263,0.09100499315065447,1.0409347786867502,0.30159889071320467,0.5205702601431788,2356]
["Low","Q9Y6A1","Protein O-mannosyl-transferase 1 [OS=Homo sapiens]",1,1,1,1,747,84.8,8.4,1.87,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","POMT1","ENSG00000130714","","O-linked glycosylation; Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2; Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1","Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Metabolic pathways",28.7,22.2,23,22.4,22.7,17.9,1.1730158730158733,0.23022253575887247,0.23011863902268148,0.6380482031616056,0.4750836418532779,0.3232299230119911,3782]
["High","Q9Y6A4","Cilia- and flagella-associated protein 20 [OS=Homo sapiens]",54,8,19,8,193,22.8,9.76,32.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","","CFAP20","ENSG00000070761","","","",650.2,512.4,699.6,596,825.6,675.5,0.8879881741452481,-0.1713876313926237,0.42179376391613693,0.3748998454519875,0.6444942678389818,0.19078094092806488,5110]
["High","Q9Y6A5","Transforming acidic coiled-coil-containing protein 3 [OS=Homo sapiens]",48,33,102,33,838,90.3,5.05,203.73,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","","TACC3","ENSG00000013810","","Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus","",5684.3,5655,5233.2,3591.5,2988.7,3141.8,1.7046389631763013,0.76946621362477,6.0052030685646971E-4,3.2214723021551697,0.031052069906856397,1.507909444789704,151]
["High","Q9Y6A9","Signal peptidase complex subunit 1 [OS=Homo sapiens]",17,2,5,2,102,11.8,9.31,8.44,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","translation activity;other molecular function","SPCS1","ENSG00000114902","","","Protein export",325.2,308.3,319.9,295.5,299,283.6,1.0857533310556886,0.1186963789397688,0.021281602025385482,1.671995682551945,0.15357370481904792,0.8136831386638603,1082]
["High","Q9Y6B6","GTP-binding protein SAR1b [OS=Homo sapiens]",31,6,24,2,198,22.4,6.11,44.54,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SAR1B","ENSG00000152700","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Chylomicron assembly","Protein processing in endoplasmic reticulum; Legionellosis",143.1,130.6,129.4,120.6,125.7,116.2,1.112,0.15315678806142052,0.05892332818822244,1.229712730720139,0.2423990234423819,0.6154691341527775,1898]
["High","Q9Y6B7","AP-4 complex subunit beta-1 [OS=Homo sapiens]",5,2,3,2,739,83.2,5.86,0,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","AP4B1","ENSG00000134262","","Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis","Lysosome",41.7,25.1,43.6,35.5,46,33.9,0.9566724436741768,-0.06390305186731338,0.8233735707806856,0.08440307740207748,0.9017956011580296,0.044891887456431835,7129]
["High","Q9Y6C9","Mitochondrial carrier homolog 2 [OS=Homo sapiens]",23,7,23,7,303,33.3,7.97,72.58,"other biological processes","other membranes;mitochondrion","","MTCH2","ENSG00000109919; ENSG00000285121","","","",1351.6,2114,1499,1456.3,1567.1,1589.3,1.0762893749864506,0.10606601816435123,0.6466966000807612,0.18929942229093136,0.7938071142006892,0.10028501320882836,6361]
["High","Q9Y6D0","selenoprotein K [OS=Homo sapiens]",10,1,2,1,94,10.6,10.86,2.47,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","SELENOK","ENSG00000113811","Selenium micronutrient network","","",72.7,103.5,100.5,66.2,69.5,64.6,1.381427858212681,0.46616022279724706,0.062001483264643026,1.2075979207284508,0.24813305039996553,0.6053153854643335,1951]
["High","Q9Y6D5","Brefeldin A-inhibited guanine nucleotide-exchange protein 2 [OS=Homo sapiens]",16,27,51,17,1785,201.9,6.33,82.37,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARFGEF2","ENSG00000124198","","Association of TriC/CCT with target proteins during biosynthesis","Endocytosis",765.5,760.7,811.9,844.8,866,873.1,0.9048724795851232,-0.1442136021753609,0.011234560685236403,1.9494439055063522,0.1155723976684135,0.9371458767431972,759]
["High","Q9Y6D6","Brefeldin A-inhibited guanine nucleotide-exchange protein 1 [OS=Homo sapiens]",29,38,88,28,1849,208.6,5.85,167.77,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","ARFGEF1","ENSG00000066777","","","Endocytosis",3581.5,3140.9,3634.8,4155.9,4418.1,4217.3,0.8097065974529564,-0.30452886229921367,0.009837274523107285,2.0071252088379645,0.10879524005158879,0.9633901052311329,706]
["High","Q9Y6D9","mitotic spindle assembly checkpoint protein MAD1 [OS=Homo sapiens]",40,31,76,31,718,83,5.92,179.87,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD1L1","ENSG00000002822","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; CCL18 signaling pathway","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Viral carcinogenesis",3215.4,3073.1,3133.1,2919.3,2905.5,2905,1.0792458017365807,0.1100234807302488,5.139758207239279E-3,2.289057311302723,0.07629511802685227,1.1175032507978266,526]
["High","Q9Y6E0","Serine/threonine-protein kinase 24 [OS=Homo sapiens]",38,13,53,8,443,49.3,5.69,111.9,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","STK24","ENSG00000102572","","Apoptotic cleavage of cellular proteins","",1227,1901,1190.9,1252.4,1170.4,1198.4,1.1926709378106701,0.2541960531979321,0.3731665033782996,0.4280973468410197,0.6056296109702273,0.21779289908494842,4811]
["High","Q9Y6E2","Basic leucine zipper and W2 domain-containing protein 2 [OS=Homo sapiens]",48,20,81,16,419,48.1,6.68,148.74,"developmental processes;other biological processes","other cell component","","BZW2","ENSG00000136261","","","",2331.8,2031,2328.5,2277.8,2426.4,2377.9,0.9448186272433317,-0.08189068691915141,0.2976604110593112,0.5262789228332538,0.542008509690089,0.26599389485933206,4288]
["High","Q9Y6G5","COMM domain-containing protein 10 [OS=Homo sapiens]",12,2,3,2,202,23,6.54,2.65,"","nucleus;other cell component","","COMMD10","ENSG00000145781","","Neddylation","",15.5,19.3,20,27.2,23.8,23,0.7405405405405404,-0.4333493775557857,0.028111737197255696,1.5511123158343796,0.17324107658735002,0.7613491260591855,1267]
["High","Q9Y6G9","Cytoplasmic dynein 1 light intermediate chain 1 [OS=Homo sapiens]",59,24,78,24,523,56.5,6.42,187.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","DYNC1LI1","ENSG00000144635","Ciliary landscape; Intraflagellar transport proteins binding to dynein","Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MHC class II antigen presentation; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection",3442.8,3040.8,3376,3394.5,3507.3,3516.2,0.9464004607410251,-0.0794773188548107,0.22661546871695099,0.6447104486247622,0.47108987746058395,0.3268962275602001,3756]
["High","Q9Y6H1","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 [OS=Homo sapiens]",34,3,6,3,151,15.5,9.22,12.94,"cell organization and biogenesis;stress response;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","CHCHD2","ENSG00000106153","","Mitochondrial protein import","",172.4,195,203.2,244.9,210,214.9,0.8518960883845923,-0.23125062912499628,0.08147719910613828,1.0889639089018226,0.2850241803856307,0.5451182945087283,2232]
["High","Q9Y6I3","epsin-1 [OS=Homo sapiens]",18,8,17,1,576,60.3,4.83,58.15,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","EPN1","ENSG00000063245","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway","Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation","Endocytosis",200.2,173.8,189,193.3,170.3,159,1.077305778798316,0.10742779764757103,0.3475320192091976,0.4590051763249207,0.5854433669871445,0.23251511014680118,4635]
["High","Q9Y6I3-1","Isoform 2 of Epsin-1 [OS=Homo sapiens]",16,8,17,1,662,69,5.05,58.01,"","","","EPN1","","","","",672.1,599.9,682.7,635.2,573,563.9,1.1030415890751089,0.1414871873221097,0.15093125946930822,0.8212208039017934,0.38212427818948075,0.41779536862207733,3084]
["High","Q9Y6I4-1","Ubiquitin carboxyl-terminal hydrolase 3 [OS=Homo sapiens]",21,8,11,8,520,58.9,8.18,20.69,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","USP3","ENSG00000140455","","Ub-specific processing proteases","",488.1,440.9,504.6,522.9,506,536.8,0.9156287922335057,-0.12716526528407102,0.10475801309176355,0.9798127472787478,0.32215461450196525,0.4919356434938346,2539]
["High","Q9Y6I9","Testis-expressed protein 264 [OS=Homo sapiens]",15,3,6,3,313,34.2,4.86,12.37,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TEX264","ENSG00000164081","","Platelet degranulation","",259.9,267.7,255.1,274.8,255.9,222,1.0398565165404543,0.05638447340827941,0.5629625683853936,0.24952048060887727,0.7387582746139753,0.13149764167879147,5950]
["High","Q9Y6J0","Calcineurin-binding protein cabin-1 [OS=Homo sapiens]",7,11,17,11,2220,246.2,6.02,37.06,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity","CABIN1","ENSG00000099991","","Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",709.5,705.8,678.3,679.6,656.9,670,1.043408921006728,0.061304673380677105,0.07025009906864019,1.153353058968314,0.2654950501103304,0.5759435714932805,2066]
["High","Q9Y6J9","TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L [OS=Homo sapiens]",15,7,13,7,622,67.8,8.97,17.17,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF6L","ENSG00000162227","","HATs acetylate histones","Basal transcription factors",581,560.1,566.2,613.2,611.7,637.8,0.9165727170236754,-0.12567875222603603,0.007834432069813572,2.1059924807379358,0.09648461451278292,1.0155419339610332,634]
["High","Q9Y6K1","DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",44,31,99,4,912,101.8,6.57,170.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT3A","ENSG00000119772","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency","RMTs methylate histone arginines; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer",2894.3,2255.9,2851.1,3055.6,3133.7,3100.2,0.8613273050217989,-0.21536652787847108,0.10695956593218708,0.9707803682146439,0.32609929355662504,0.4866501420244381,2561]
["High","Q9Y6K1-2","Isoform 2 of DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",49,28,94,1,723,81.6,6.81,160.75,"","","","DNMT3A","","","","",34.5,32.9,31.1,40.9,45.7,42.9,0.7606177606177608,-0.39475646823017735,0.003730665354302838,2.428213706010856,0.06473118908088124,1.1888864151275644,450]
["Medium","Q9Y6K5","2'-5'-oligoadenylate synthase 3 [OS=Homo sapiens]",1,1,1,1,1087,121.1,8.4,2.19,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS3","ENSG00000111331","Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction","Interferon gamma signaling; OAS antiviral response; Interferon alpha/beta signaling","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease",18.2,12.9,16.5,20.3,21.8,25.2,0.7072808320950966,-0.4996449313023735,0.036890827915947555,1.4330815980859426,0.19305870265932876,0.7143106165639572,1492]
["High","Q9Y6K8","Adenylate kinase isoenzyme 5 [OS=Homo sapiens]",8,3,3,3,562,63.3,5.07,8.18,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK5","ENSG00000154027","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors",71.7,49.1,70.8,87.3,68.3,89.5,0.7817217462260303,-0.35527292313065917,0.1489094645424981,0.8270776980305545,0.3798383205317952,0.42040122296925375,3061]
["High","Q9Y6K9","NF-kappa-B essential modulator [OS=Homo sapiens]",10,4,4,4,419,48.2,5.71,10.06,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IKBKG","ENSG00000269335","Nucleotide-binding oligomerization domain (NOD) pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","Downstream TCR signaling; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; TICAM1, RIP1-mediated IKK complex recruitment; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Ovarian tumor domain proteases; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Primary immunodeficiency; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",178.3,291.8,247.1,307,220.2,234.6,0.9414544499868732,-0.0870367996949652,0.7444431497311832,0.12816846204981572,0.853916866916568,0.06858440799577872,6807]
["High","Q9Y6M1","Insulin-like growth factor 2 mRNA-binding protein 2 [OS=Homo sapiens]",42,22,106,19,599,66.1,8.46,221.34,"transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP2","ENSG00000073792","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",3051.2,3210.8,2977.8,3260.3,3145.4,3144,0.9675487188079205,-0.04759378803548612,0.26027622498948494,0.5845655008398457,0.5066658600642978,0.2952783581628571,4011]
["High","Q9Y6M4-4","Isoform 4 of Casein kinase I isoform gamma-3 [OS=Homo sapiens]",13,4,6,1,424,49,9.11,8.8,"","","","CSNK1G3","","","","",12.6,16.2,11.4,16.2,11.2,11.4,1.0360824742268042,0.05113884899180106,0.8409429116108078,0.0752334857882288,0.9120825467227653,0.03996585469363475,7199]
["High","Q9Y6M5","zinc transporter 1 [OS=Homo sapiens]",31,10,20,10,507,55.3,6.48,52.13,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A1","ENSG00000170385","Zinc homeostasis","Zinc efflux and compartmentalization by the SLC30 family","Mineral absorption",637.5,631.9,652.8,489.9,507.5,489.5,1.2927567422153472,0.3704508290412061,7.2866287635698059E-5,4.137473356184015,0.01210510582679852,1.9170314094610972,47]
["High","Q9Y6M7-7","Isoform 7 of Sodium bicarbonate cotransporter 3 [OS=Homo sapiens]",12,16,29,16,1259,140.7,6.62,38.28,"","","","SLC4A7","","","","",873.5,793,977.4,970,1099.4,1050.4,0.8474581703955382,-0.23878593472361348,0.07220121043710195,1.1414555215197302,0.268450976710901,0.5711350115950139,2100]
["Medium","Q9Y6N6","Laminin subunit gamma-3 [OS=Homo sapiens]",1,1,1,1,1575,171.1,6.58,0,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes","other molecular function","LAMC3","ENSG00000050555","Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Small cell lung cancer; Malignant pleural mesothelioma","Non-integrin membrane-ECM interactions; Laminin interactions; MET activates PTK2 signaling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer",26.8,11.5,33,24.7,36.7,29.6,0.7835164835164835,-0.35196446864217057,0.4178813140228521,0.3789470483304147,0.6407732325000843,0.19329563865339708,5092]
["High","Q9Y6N7","Roundabout homolog 1 [OS=Homo sapiens]",9,12,16,12,1651,180.8,6.04,30.93,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ROBO1","ENSG00000169855","Development of ureteric collection system","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; SLIT2:ROBO1 increases RHOA activity","Axon guidance",612.4,579.2,633.8,580.1,538.4,510.4,1.120633556387746,0.1643145985636271,0.06363856916481311,1.1962795934945303,0.2509545192115458,0.600404979097426,1980]
["High","Q9Y6P5","Sestrin-1 [OS=Homo sapiens]",5,2,2,2,492,56.5,6.09,4.43,"other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","SESN1","ENSG00000080546","miRNA regulation of DNA damage response; Mesodermal commitment pathway; Head and neck squamous cell carcinoma; p53 transcriptional gene network; DNA damage response","Amino acids regulate mTORC1","p53 signaling pathway; Longevity regulating pathway",59.8,83.1,71.8,62.1,61.9,63.1,1.1475146980224478,0.198512632617989,0.24383929620460607,0.6128963038464691,0.49247212228804044,0.3076183488803679,3866]
["High","Q9Y6Q1","Calpain-6 [OS=Homo sapiens]",5,3,3,3,641,74.5,7.05,6.71,"cell organization and biogenesis;protein metabolism;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CAPN6","ENSG00000077274","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",106.4,88.2,108.4,121.4,139.5,135.2,0.7649583438525625,-0.38654690754430643,0.021197270946886768,1.6737200489297401,0.1532484181048999,0.8146039997580544,1080]
["High","Q9Y6Q2-3","Isoform 3 of Stonin-1 [OS=Homo sapiens]",11,8,10,7,1135,127.2,5.31,16.27,"","","","STON1","","","","",408.1,343.8,403.2,503.6,496.4,487,0.7767989240080699,-0.36438689249443923,0.006451875429206724,2.1903140264241796,0.08466595521217832,1.0722911874940937,595]
["High","Q9Y6Q3-1","zinc finger protein 37 homolog [OS=Homo sapiens]",15,7,7,6,630,71.2,9.09,11.29,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZFP37","ENSG00000136866","","Generic Transcription Pathway","Herpes simplex virus 1 infection",177.1,215.7,189.3,224.1,222.8,215.8,0.878376339218349,-0.18708890182851495,0.08290696567546217,1.081408979373385,0.28770559466400386,0.541051692826112,2250]
["High","Q9Y6Q9-1","Nuclear receptor coactivator 3 [OS=Homo sapiens]",4,4,4,4,1424,155.2,7.47,2.79,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NCOA3","ENSG00000124151","Androgen receptor signaling pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway","Estrogen-dependent gene expression; MAPK6/MAPK4 signaling; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Endocrine resistance; Estrogen signaling pathway; Thyroid hormone signaling pathway; Pathways in cancer; Breast cancer",149,155.2,156.3,113.1,100.5,114.5,1.4035355074672355,0.489065562460278,9.0794009590057935E-4,3.0419428044283046,0.03673158688493121,1.434960308777443,193]
["High","Q9Y6R0","Numb-like protein [OS=Homo sapiens]",10,5,9,3,609,64.9,8.85,22.59,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction","other cell component","","NUMBL","ENSG00000105245","Notch signaling; Notch signaling pathway","","Notch signaling pathway",111.2,113.4,106.4,104.5,103.1,93.1,1.100764881942135,0.13850634912057708,0.07132533219339947,1.1467561969660232,0.2674871247675615,0.5726971174819051,2082]
["High","Q9Y6R4-1","Mitogen-activated protein kinase kinase kinase 4 [OS=Homo sapiens]",6,9,15,9,1608,181.6,6.32,20.28,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","kinase activity;other molecular function","MAP3K4","ENSG00000085511","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)","","MAPK signaling pathway; GnRH signaling pathway",471.1,412.4,489.4,436.8,422.2,450.3,1.048575574734591,0.06843084556952847,0.4374360939051035,0.3590853851367627,0.6531843605299384,0.1849642223077829,5229]
["Medium","Q9Y6V0-1","Protein piccolo [OS=Homo sapiens]",0,1,4,1,5065,552.9,6.51,8.88,"","","","","","","","",92.3,85.1,85.1,76,66.6,85,1.1533391915641478,0.20581686513426561,0.11668116266933143,0.9329992520018033,0.3396892312163086,0.46891822085874807,2682]
["High","Q9Y6V7","Probable ATP-dependent RNA helicase ddx49 [OS=Homo sapiens]",14,4,9,4,483,54.2,9.06,20.08,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX49","ENSG00000105671","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",238.7,201.9,260.7,255.4,298.1,279.8,0.8415936637465499,-0.24880425208680723,0.10593753044025285,0.9749501553259619,0.3242494071648351,0.48912080927711643,2551]
["High","Q9Y6W3","Calpain-7 [OS=Homo sapiens]",18,11,17,11,813,92.6,7.65,31.21,"protein metabolism;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CAPN7","ENSG00000131375","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",466.6,465.6,535.9,519.5,526,485.8,0.9587278782733624,-0.06080671069266857,0.4694791816517751,0.32838366110652784,0.673716862771009,0.17152258235379705,5441]
["High","Q9Y6W5","Wiskott-Aldrich syndrome protein family member 2 [OS=Homo sapiens]",17,10,22,10,498,54.3,5.53,38.22,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","WASF2","ENSG00000158195","Regulation of actin cytoskeleton","RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs","Adherens junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Choline metabolism in cancer",1029.4,959.4,975.7,1081.8,1048,977.5,0.9540437035368325,-0.06787273910553245,0.2709466860505526,0.5671161564757641,0.5175028680730711,0.286087238943785,4088]
["High","Q9Y6X2","E3 SUMO-protein ligase PIAS3 [OS=Homo sapiens]",3,2,2,2,628,68,7.69,5.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","PIAS3","ENSG00000131788","Androgen receptor signaling pathway; Prolactin signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; EGF/EGFR signaling pathway; Regulatory circuits of the STAT3 signaling pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Interferon type I signaling pathways","SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMOylation of immune response proteins; SUMOylation of DNA replication proteins","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway",56.6,41.9,53.8,46.9,54.5,55,0.9737851662404093,-0.03832457082005986,0.8061423741466877,0.09358824994950317,0.8914260950768074,0.04991465678564715,7061]
["High","Q9Y6X3-1","MAU2 chromatid cohesion factor homolog [OS=Homo sapiens]",5,2,2,2,613,69,7.25,5.55,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MAU2","ENSANAG00000026794; ENSCANG00000033671; ENSCATG00000015302; ENSCCAG00000031923; ENSCSAG00000005122; ENSG00000129933; ENSGGOG00000002989; ENSMFAG00000041829; ENSMNEG00000034232; ENSPPAG00000032359; ENSPTRG00000010738; ENSRBIG00000036077; ENSRROG00000032649; ENSSBOG00000034577","Cohesin complex - Cornelia de Lange syndrome","Cohesin Loading onto Chromatin","",66.8,105.2,109.2,117.6,90.3,96.8,0.9228749589760421,-0.11579290561395017,0.6465855849271962,0.18937398184070056,0.7940453361295293,0.1001547007608193,6358]
["High","Q9Y6X4-1","Soluble lamin-associated protein of 75 kDa [OS=Homo sapiens]",13,6,9,6,670,74.9,4.6,21.39,"","other membranes;nucleus","","FAM169A","ENSG00000198780","","RHOF GTPase cycle","",335,343.7,344,419.5,423.6,400.4,0.8224366706875754,-0.2820235022431664,0.000680650543391781,3.167075804430447,0.032604413759527766,1.486723604175769,163]
["High","Q9Y6X5","Bis(5'-adenosyl)-triphosphatase ENPP4 [OS=Homo sapiens]",5,2,2,2,453,51.6,6.15,2.38,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes","other molecular function","ENPP4","ENSG00000001561","","Neutrophil degranulation","Purine metabolism; Metabolic pathways",12,11.3,12.8,12.6,11.3,16.5,0.8935643564356436,-0.16235645586462372,0.4266213783154757,0.3699573855208766,0.6475621543326661,0.18871854077840683,5144]
["High","Q9Y6X8","Zinc fingers and homeoboxes protein 2 [OS=Homo sapiens]",2,2,2,2,837,92.3,6.86,3.13,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZHX2","ENSG00000178764","","","",47.6,56.6,52.7,55.2,62.4,55.6,0.905889145496536,-0.14259357775862705,0.19549182235444632,0.7088714049209004,0.4368632366753053,0.35965450090917717,3494]
["High","Q9Y6X9-1","MORC family CW-type zinc finger protein 2 [OS=Homo sapiens]",23,18,39,18,1032,117.8,8.38,66.76,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","MORC2","ENSG00000133422","","Fatty acyl-CoA biosynthesis","",1965.5,1818.8,1771.2,1677,1681.6,1743.3,1.0889080538622866,0.12288213969562174,0.07208124015333664,1.1421777499546653,0.2682604018671365,0.571443429153569,2098]
["High","Q9Y6Y0","influenza virus NS1A-binding protein [OS=Homo sapiens]",10,5,7,5,642,71.7,5.53,11.53,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","IVNS1ABP","ENSG00000116679","","","",230.6,211.9,289.1,522.2,624.7,581.2,0.4233551299114634,-1.2400597241827773,9.174881196026282E-4,3.0373995506447304,0.03692653215390372,1.432661475916321,194]
["High","Q9Y6Y8","SEC23-interacting protein [OS=Homo sapiens]",14,16,38,16,1000,111,5.54,49.87,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC23IP","ENSG00000107651","","COPII-mediated vesicle transport","",1229.9,926.9,1196.1,1283.9,1198.4,1250.3,0.8982746610941436,-0.15477145658885488,0.2703867306604955,0.5680146253869435,0.5170657832469138,0.28645420065130517,4083]

{"sheet":"F-P","index":3,"n_rows":7809,"n_cols":32,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["Protein FDR Confidence: Combined","Accession","Description","Coverage [%]","# Peptides","# PSMs","# Unique Peptides","# AAs","MW [kDa]","calc. pI","Score Sequest HT: Sequest HT","Biological Process","Cellular Component","Molecular Function","Gene Symbol","Ensembl Gene ID","WikiPathways","Reactome Pathways","KEGG Pathways","Abundances (Normalized): F19: 130N, Sample, F-P","Abundances (Normalized): F19: 131N, Sample, F-P","Abundances (Normalized): F19: 132N, Sample, F-P","Abundances (Normalized): F19: 126, Sample, DMSO","Abundances (Normalized): F19: 127C, Sample, DMSO","Abundances (Normalized): F19: 128C, Sample, DMSO","Ratio","log2(Ratio)","P-Value","− log10(P-Value)","q-Value","− log10(q-Value)","Rank (P-Value)"]
["Medium","A0A0B4J2F0","Protein PIGBOS1 [OS=Homo sapiens]",19,1,1,1,54,6.3,8.5,0,"stress response;other biological processes","other membranes;mitochondrion","","PIGBOS1","ENSG00000225973","","","",46.2,47.3,57.4,51.5,54.7,56.6,{"$f":"AVERAGE(T2:V2)/AVERAGE(W2:Y2)","v":0.9269041769041769},{"$f":"LOG(Z2,2)","v":-0.10950789373956374},{"$f":"TTEST(T2:V2,W2:Y2,2,2)","v":0.36246194184678737},{"$f":"-LOG10(AB2)","v":0.44073758719957157},{"$f":"AB2*7808/AF2","v":0.5639902036547859},{"$f":"-LOG10(AD2)","v":0.2487284395195279},5018]
["High","A0AV96","RNA-binding protein 47 [OS=Homo sapiens]",13,6,11,6,593,64.1,7.68,29.14,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","RBM47","ENSG00000163694","TYROBP causal network in microglia","","",245.3,256.8,252.7,338,389.1,365.5,0.6908292147171884,-0.533599000097549,1.7472040929311149E-3,2.757656361613111,0.027339017149511313,1.5632171025778654,499]
["High","A0AVF1","intraflagellar transport protein 56 [OS=Homo sapiens]",10,4,5,4,554,64.1,6.93,8.28,"cell organization and biogenesis;transport;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","TTC26","ENSG00000105948","Ciliary landscape; Genes related to primary cilium development (based on CRISPR)","Intraflagellar transport","",171.7,178.3,140.8,164.5,182.6,155.9,0.9757455268389662,-0.03542315102998444,0.7856276110781917,0.10478326156507788,0.8822350621743882,0.05441568629205818,6953]
["High","A0AVT1-1","Ubiquitin-like modifier-activating enzyme 6 [OS=Homo sapiens]",33,26,66,26,1052,117.9,6.14,133.34,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBA6; UBE1L2","ENSG00000033178","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",2027.3,2007.6,2098.9,2226.3,2165.4,2198.9,0.9306891633538674,-0.10362868582101749,0.009775933502218894,2.0098417612461215,0.06441391458677224,1.191020306933609,1185]
["High","A0FGR8-2","Isoform 2 of Extended synaptotagmin-2 [OS=Homo sapiens]",17,12,21,12,893,98.8,8.68,40.11,"","","","ESYT2","","","","",679,705.6,707.8,655.7,659.6,616.4,1.0831909716829733,0.1152876193186756,0.03214572651687482,1.4928767544193917,0.12760235518238872,0.894141309680093,1967]
["High","A0JLT2","Mediator of RNA polymerase II transcription subunit 19 [OS=Homo sapiens]",11,1,1,1,244,26.3,9.82,3.66,"other biological processes","nucleus","other molecular function","MED19","ENSG00000156603","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",29.9,27.5,40.9,28.4,27.5,26.2,1.197320341047503,0.25980919456277585,0.2654473618801153,0.5760215864900942,0.46460726329521185,0.3329140050730755,4461]
["High","A0JNW5-1","UHRF1-binding protein 1-like [OS=Homo sapiens]",16,14,18,14,1464,164.1,6.32,42.2,"","cytosol;other cytoplasmic organelle","other molecular function","UHRF1BP1L","ENSG00000111647","","RND2 GTPase cycle","",591.8,576.8,649.8,616.9,586.5,595.9,1.0106152392597119,0.01523383990587694,0.8039380126197242,0.09477743609611795,0.8931627778222547,0.04906938426073994,7028]
["High","A0MZ66","Shootin-1 [OS=Homo sapiens]",29,17,34,17,631,71.6,5.33,61.53,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SHTN1","ENSG00000187164","","Recycling pathway of L1","",1249,1167.8,1236.8,1363.7,1291.1,1246.9,0.936412333085578,-0.09478415919413188,0.12293415692043844,0.9103274328087568,0.2907815502074472,0.536433152480433,3301]
["Medium","A0PJW6","Transmembrane protein 223 [OS=Homo sapiens]",4,1,1,1,202,22,11.02,0,"developmental processes","other membranes","","TMEM223","ENSG00000168569","","","",74,59.5,69.5,72.8,60.3,73.5,0.9825750242013555,-0.02536052679252068,0.8527359063777571,0.06918544967834948,0.9216724746674319,0.03542338232516344,7224]
["Medium","A0PJZ3","Glucoside xylosyltransferase 2 [OS=Homo sapiens]",2,1,1,1,443,51,9.77,0,"protein metabolism;other metabolic processes","other membranes","other molecular function","GXYLT2","ENSG00000172986","Vitamin D receptor pathway","","Other types of O-glycan biosynthesis",26.7,35.5,35.2,23.5,27.1,26.6,1.261658031088083,0.3353209248142618,0.09533612691593688,1.020742495509495,0.24879160393035932,0.6041642800432834,2992]
["High","A0PK00","Transmembrane protein 120B [OS=Homo sapiens]",9,2,3,2,339,40.2,8.9,8.9,"cell organization and biogenesis;transport;other biological processes","other membranes;nucleus","","TMEM120B","ENSG00000188735","","","",125.8,137.8,129.9,105,131.5,116.9,1.113469156762875,0.1550615958432319,0.18815800164690508,0.7254773080525667,0.37815641617993173,0.4223285265308644,3885]
["Medium","A1A5C7-1","Solute carrier family 22 member 23 [OS=Homo sapiens]",1,1,1,1,686,73.7,7.74,2.24,"transport","other membranes","transporter activity","SLC22A23","ENSG00000137266","","","",83.3,84.7,96.3,128.9,96.6,105.7,0.7980072463768118,-0.32552624785775514,0.10001797080445454,0.9999219607998263,0.25604600525940363,0.5916819954879767,3050]
["High","A1L020","RNA-binding protein MEX3A [OS=Homo sapiens]",22,8,18,8,520,54.1,7.27,58.94,"","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MEX3A","ENSG00000254726","","","",500.2,449.6,496.3,630.8,595.1,607.7,0.7886671029668411,-0.3425116289268988,2.6060419329187036E-3,2.584018600485028,0.031208551245750366,1.5057263915583126,652]
["High","A1L0T0","Acetolactate synthase-like protein [OS=Homo sapiens]",22,11,18,11,632,67.8,8.15,54.07,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ILVBL","ENSG00000105135","","","",722.1,810.5,785.5,718.7,838.7,802.7,0.9822041438922077,-0.025905185650691716,0.7674259452155787,0.11496352221682295,0.8713191479196217,0.05982274190021007,6877]
["High","A1L170","Uncharacterized protein C1orf226 [OS=Homo sapiens]",8,1,1,1,272,29,5.27,3.81,"","","","C1orf226","ENSG00000239887","","","",40,35.7,43.5,37.7,32.4,29.6,1.1955867602808428,0.25771882606396596,0.11820092969935064,0.9273791075350517,0.28327589290746774,0.5477903828489069,3258]
["High","A1X283","SH3 and PX domain-containing protein 2B [OS=Homo sapiens]",22,17,37,17,911,101.5,8.69,68.96,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytoskeleton;other cell component","enzyme regulator activity;other molecular function","SH3PXD2B","ENSG00000174705","","","",1814.4,1658.3,1883.1,1822.6,1692.6,1699.3,1.027097516540416,0.038573163107315234,0.5822230701808575,0.23491058994197378,0.7468371499872081,0.1267740870363468,6087]
["High","A2AJT9-1","BCLAF1 and THRAP3 family member 3 [OS=Homo sapiens]",9,6,7,6,711,83.8,9.7,7.11,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","BCLAF3","ENSG00000173681","","","",310.5,329.3,303.8,357.1,344.1,359.4,0.8896850839147652,-0.16863332990128338,0.012302375848608587,1.910011009023918,0.07277041714086048,1.1380451355711325,1320]
["High","A2RRP1-1","neuroblastoma-amplified sequence [OS=Homo sapiens]",8,15,28,15,2371,268.4,5.96,49.89,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","NBAS","ENSG00000151779","","COPI-dependent Golgi-to-ER retrograde traffic","",1071.8,1117.3,1119.9,1131.1,1232.1,1154.8,0.9405912450255827,-0.0883601911594223,0.11177758385115819,0.9516452821905937,0.27350654174548517,0.5630322817254688,3191]
["High","A2RTX5","Probable threonine--tRNA ligase 2, cytoplasmic [OS=Homo sapiens]",7,4,5,4,802,92.6,6.05,12.01,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","TARS3","ENSG00000185418","","","Aminoacyl-tRNA biosynthesis",114.6,117.2,117.2,135.7,126.2,131.5,0.8871377732587697,-0.17276992118151555,6.812783683589764E-3,2.1666754003626343,0.052305029499969395,1.2814565486267437,1017]
["High","A2RU67","Protein FAM234B [OS=Homo sapiens]",2,1,2,1,622,67,5.02,6.52,"","other membranes;cytoskeleton;ER/Golgi","","FAM234B","ENSG00000084444","","","",79.7,69.5,75.8,84.8,85.6,90.6,0.8620689655172413,-0.2141248053528475,0.02613944540634519,1.5827036309681395,0.11382977676115072,0.9437441158716869,1793]
["Medium","A2RUB1","Meiosis-specific coiled-coil domain-containing protein MEIOC [OS=Homo sapiens]",1,1,1,1,952,107.5,7.12,1.86,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","MEIOC","ENSG00000180336","","","",9.3,18.4,14.5,34.2,28.7,27.7,0.46578366445916114,-1.10226805133905,0.008294163062279265,2.0812274307091654,0.058554091492112575,1.2324427530192092,1106]
["High","A2RUC4","tRNA wybutosine-synthesizing protein 5 [OS=Homo sapiens]",18,5,6,5,315,36.5,7.55,9.39,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TYW5","ENSG00000162971","","Synthesis of wybutosine at G37 of tRNA(Phe)","",169.6,194.7,179.8,180.7,191.2,169.2,1.0055442616891517,0.007976587077399015,0.9225991126303817,0.034986967438476096,0.9590805314096685,0.01814492476004863,7511]
["High","A2VDJ0","Transmembrane protein 131-like [OS=Homo sapiens]",1,1,1,1,1609,179.2,6.86,2.49,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","TMEM131L","ENSG00000121210","","","",47.2,64.1,49.7,50.6,64.3,55.7,0.9437280187573269,-0.08355695831631109,0.6537002664376164,0.18462133802266542,0.7985124656359368,0.09771829966996505,6392]
["High","A3KMH1","von Willebrand factor A domain-containing protein 8 [OS=Homo sapiens]",12,16,18,16,1905,214.7,7.4,32.67,"","mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","VWA8","ENSG00000102763","","","",451.2,502.5,446.1,498.2,526.8,507.2,0.9135883043989037,-0.13038391320335924,0.09073812336984373,1.0422102069803982,0.240980703153653,0.61801773273392,2940]
["High","A3KN83-1","protein strawberry notch homolog 1 [OS=Homo sapiens]",21,17,54,17,1393,154.2,7.88,87.98,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SBNO1","ENSG00000139697","","","",1028.1,1074.2,1066,951.9,922.4,922.1,1.1329924188242027,0.18013820770624922,0.002007871062888077,2.6972641792133323,0.028925197894889496,1.538723661093084,542]
["High","A4D1E9-1","GTP-binding protein 10 [OS=Homo sapiens]",13,5,13,5,387,42.9,9.03,25.82,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","GTPBP10","ENSG00000105793","","","",919.4,886.1,885.9,844.2,903.5,917.3,1.009906191369606,0.014221289480731755,0.7429443540099732,0.12904371336112314,0.8573617375273235,0.06683590215444951,6766]
["Medium","A4D1F6","Leucine-rich repeat and death domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,860,98,7.46,0,"signal transduction;other biological processes","","","LRRD1","ENSG00000240720","","","",22.5,18.1,9.5,17.4,16.8,18.8,0.9452830188679244,-0.08118175625535327,0.8147409470474015,0.08898045647705756,0.8994058128864854,0.04604430990086929,7073]
["High","A4D1P6-1","WD repeat-containing protein 91 [OS=Homo sapiens]",3,1,1,1,747,83.3,6.58,4.28,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle","enzyme regulator activity","WDR91","ENSG00000105875","","CDC42 GTPase cycle","",28,20.9,33.1,29,30.9,35.5,0.859538784067086,-0.21836535650006553,0.32982096103801595,0.48172174719401567,0.531964896464538,0.27411702517626996,4841]
["High","A4D1S0-1","killer cell lectin-like receptor subfamily G member 2 [OS=Homo sapiens]",21,8,17,8,409,42.8,5.87,31.59,"","other membranes","other molecular function","KLRG2","ENSG00000188883","","","",706.1,665,732.4,739.8,625.8,634.6,1.0516448355164485,0.07264755581560814,0.45377340856046,0.34316095766621507,0.645954926898828,0.18979778491830962,5485]
["High","A5A3E0","POTE ankyrin domain family member F [OS=Homo sapiens]",11,10,366,1,1075,121.4,6.2,713.12,"","other cell component","","POTEF","ENSG00000196604","","","",33.4,44.3,36.2,28.7,33.4,31.7,1.2142857142857142,0.2801079191927352,0.13177400899171518,0.8801702412184725,0.3028823851066565,0.5187259834298651,3397]
["High","A5LHX3","proteasome subunit beta type-11 [OS=Homo sapiens]",5,1,1,1,300,32.5,6.46,2.96,"protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","other molecular function","PSMB11","ENSG00000222028","","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling","Proteasome",35,42.8,34.8,37,30,28.3,1.1815320041972717,0.24065870817028756,0.19844878447481942,0.7023515568600944,0.38961229800839575,0.40936734318743945,3977]
["High","A5PLN9-1","Trafficking protein particle complex subunit 13 [OS=Homo sapiens]",16,4,6,4,417,46.5,5.6,10.22,"","cytosol;ER/Golgi","","C5orf44; TRAPPC13","ENSG00000113597","","RAB GEFs exchange GTP for GDP on RABs","",140.9,126,131.8,145.9,151.6,136.6,0.9184519695922598,-0.12272381725555015,0.12780026397317434,0.893468249135564,0.2975147468999837,0.5264915027469954,3354]
["High","A5YKK6","CCR4-NOT transcription complex subunit 1 [OS=Homo sapiens]",22,46,128,46,2376,266.8,7.11,215.71,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","CNOT1","ENSG00000125107","Ciliary landscape","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",4282.7,4405.5,4282.6,4511.5,4713.7,4706.3,0.9310411657036214,-0.1030831373680578,0.014685934249621531,1.8330984205031513,0.08046861376915432,1.094373480189045,1425]
["High","A6H8Y1","Transcription factor TFIIIB component B'' homolog [OS=Homo sapiens]",1,3,4,3,2624,293.7,5.11,5.2,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","BDP1","ENSG00000145734; ENSG00000273873","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter","",280.5,303.1,258.4,330,343.8,316.3,0.8504191495808505,-0.2337540113129403,0.03112680733154649,1.5068654225040872,0.1254066623553741,0.9016793905601983,1938]
["Medium","A6NCS6","Uncharacterized protein C2orf72 [OS=Homo sapiens]",5,2,2,2,295,30.5,8.34,2.29,"","","","C2orf72","ENSG00000204128","","","",127.5,129.8,133.6,133.6,127.6,129.3,1.0010243277848911,1.4770362599489883E-3,0.9603428048556413,0.017573713124856376,0.9809467059540615,0.008354586849196278,7644]
["High","A6ND36-1","Protein FAM83G [OS=Homo sapiens]",4,3,4,3,823,90.8,6.39,4.73,"signal transduction","cytosol;nucleus","other molecular function","FAM83G","ENSG00000188522","","","",119.6,137.4,110,124.5,118.9,103.5,1.0579417699625253,0.08126022244419295,0.5467900772561486,0.2621793752892951,0.7220255239668542,0.1414474496297653,5913]
["High","A6NDB9","Paralemmin-3 [OS=Homo sapiens]",9,6,8,6,673,71.7,4.53,23.73,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PALM3","ENSG00000187867; ENSG00000288318","","","",307.9,299.8,340.5,368.5,301.4,306.7,0.9709195166905592,-0.04257638491106803,0.7228327171968294,0.14096219842367277,0.8464123959017462,0.0724179849210051,6668]
["High","A6NDG6","glycerol-3-phosphate phosphatase [OS=Homo sapiens]",46,10,23,10,321,34,6.14,47.54,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","PGP","ENSG00000184207","","Glycolysis","Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism",974.1,991.7,952.4,1068.3,979.5,1018.4,0.9517317852716719,-0.07137304086913644,0.15400867981941624,0.812454801946339,0.3355189096065854,0.4742829982777912,3584]
["High","A6NDU8","UPF0600 protein C5orf51 [OS=Homo sapiens]",45,9,22,9,294,33.6,5.26,31.35,"","cytosol;nucleus","","C5orf51","ENSG00000205765","","","",659.9,673.6,575.7,624.8,622.6,610.4,1.0276671331682634,0.039373043624406266,0.6091558369732937,0.21527158999462934,0.7672671035792026,0.11505342168756746,6199]
["High","A6NED2","RCC1 domain-containing protein 1 [OS=Homo sapiens]",8,2,3,2,376,40.1,5.27,11.52,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;other cell component","","RCCD1","ENSG00000166965","","","",142.6,142.5,169.8,157.9,145.6,173,0.954669464847849,-0.06692677950564983,0.5824553819258422,0.2347373374703002,0.7470124214975322,0.12667217657418123,6088]
["High","A6NFI3","Zinc finger protein 316 [OS=Homo sapiens]",2,2,4,2,1004,108.4,5.31,7.23,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF316","ENSG00000205903","","","Herpes simplex virus 1 infection",269.3,278.3,288.7,385.8,341.7,377.7,0.7566956207021353,-0.40221499918179443,0.003628989966199585,2.4402142325793212,0.03656148858849853,1.4369761304269963,775]
["High","A6NGB9","WAS/WASL-interacting protein family member 3 [OS=Homo sapiens]",4,1,1,1,483,49.4,10.15,2.69,"other biological processes","cytosol;cytoskeleton","cytoskeletal activity","WIPF3","ENSG00000122574","","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs","Endocytosis; Pathogenic Escherichia coli infection; Yersinia infection",27.1,21.4,23.3,15.5,22.9,23.3,1.1636952998379255,0.21871335467363356,0.330144337613865,0.481296147017781,0.5319370590361242,0.274139752160633,4846]
["High","A6NHQ2","rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 [OS=Homo sapiens]",10,4,13,1,334,34.8,10.35,37.65,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","FBLL1","ENSG00000188573","","","",13.8,30.8,25.7,24.6,22.7,26.4,0.9538670284938944,-0.0681399300225341,0.8365546661839265,0.07750567401264173,0.913285631091177,0.039393375141867595,7152]
["High","A6NHR9-1","structural maintenance of chromosomes flexible hinge domain-containing protein 1 [OS=Homo sapiens]",19,31,63,31,2005,226.2,7.3,124.61,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMCHD1","ENSG00000101596","","","",2602.8,2627.2,2754,2816.1,2908,2852.8,0.9308724597465283,-0.10334457940812432,0.021507486677019235,1.6674103374542801,0.09989914097213932,1.0004382462351158,1681]
["Medium","A6NHX0","Cytosolic arginine sensor for mTORC1 subunit 2 [OS=Homo sapiens]",6,1,2,1,329,36,5.16,0,"other biological processes","cytosol","other molecular function","CASTOR2","ENSG00000274070","","Amino acids regulate mTORC1","mTOR signaling pathway",23.2,13.9,14.3,15.8,14.1,21,1.0098231827111988,0.014102703118183275,0.9660218150295291,0.015013066089711568,0.9831462893314081,0.007381855593683359,7672]
["Medium","A6NHY2","ankyrin repeat and death domain-containing protein 1B [OS=Homo sapiens]",1,1,1,1,528,59.1,8.35,2.29,"signal transduction","","","ANKDD1B","ENSG00000189045","","","",203.4,250.6,154,230.6,219.8,166.3,0.9858926544511106,-0.020497522647070072,0.9365880492910028,0.028451388044526897,0.9679522817821509,0.014146052060935678,7555]
["High","A6NI28","Rho GTPase-activating protein 42 [OS=Homo sapiens]",2,2,3,1,874,98.5,7.99,7.83,"signal transduction;other biological processes","","enzyme regulator activity","ARHGAP42","ENSG00000165895","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",59.5,58.9,56,68.6,60.9,74.4,0.8553212358999509,-0.22546173523967025,0.07244387870985104,1.139998305221735,0.2108243775499504,0.6760791732350386,2683]
["High","A6NIH7","Protein unc-119 homolog B [OS=Homo sapiens]",69,10,32,9,251,28.1,5.68,106.26,"cell organization and biogenesis;transport;developmental processes","cytosol;other cell component","other molecular function","UNC119B","ENSG00000175970","","Trafficking of myristoylated proteins to the cilium","",951.3,920.3,971,873.3,874.4,864,1.0884098479917295,0.12222191534278236,0.00703070816098034,2.1530009289038334,0.05298819432522635,1.2758208796544122,1036]
["High","A6NJ78","Probable methyltransferase-like protein 15 [OS=Homo sapiens]",7,2,3,2,407,46.1,8.62,8.59,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","METTL15","ENSG00000169519","","","",38.5,39.6,46.1,41.9,38.9,39.7,1.0307053941908715,0.04363202710315761,0.6520892660582029,0.18569294858882784,0.7976677094442188,0.09817798835999766,6383]
["High","A6NK58","Putative lipoyltransferase 2, mitochondrial [OS=Homo sapiens]",10,2,2,2,231,25.2,8.27,0,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","LIPT2","ENSG00000175536","","Glyoxylate metabolism and glycine degradation","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors",35.6,25.2,29.9,38.3,35.6,38.1,0.8098214285714285,-0.3043242764164442,0.08586732135266582,1.0661720847884923,0.2330385975396645,0.632572142020183,2877]
["High","A6NKD9","Coiled-coil domain-containing protein 85C [OS=Homo sapiens]",8,3,3,3,419,45.2,6.96,1.63,"developmental processes","other cell component","","CCDC85C","ENSG00000205476","","","",52.7,41.1,40.4,36.1,30.1,29.8,1.397916666666667,0.4832783605916653,0.04691925021600842,1.3286489366599175,0.16195645697904232,0.7906017325907186,2262]
["High","A6NKF1","SAC3 domain-containing protein 1 [OS=Homo sapiens]",7,2,5,2,404,43.5,8.69,17.18,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","","SAC3D1","","","","",151.1,157.8,152.1,162.5,160.7,152.5,0.9690981711162497,-0.04528527464575417,0.2579710816075132,0.5884289754406057,0.4560195166836004,0.34101657004036146,4417]
["Medium","A6NMB9","Putative fidgetin-like protein 2 [OS=Homo sapiens]",1,1,1,1,653,66.6,6.73,1.79,"cell organization and biogenesis","nucleus","other molecular function","FIGNL2","ENSG00000261308","","","",34.2,29.2,32.1,34.6,36.3,30.8,0.9390363815142576,-0.09074704093438905,0.39644572789548,0.4018162577505975,0.5958514424269312,0.2248620049851583,5195]
["High","A6ZKI3","Retrotransposon Gag-like protein 8B [OS=Homo sapiens]",29,3,6,3,113,13.2,5.07,9.43,"","","","RTL8C","ENSG00000134590","","","",76.5,86.6,67.2,66.4,76.8,65.7,1.1024413595021543,0.1407019187257375,0.3440110405631828,0.4634276191182245,0.5462758195479624,0.2625880227497506,4917]
["High","A7E2V4","Zinc finger SWIM domain-containing protein 8 [OS=Homo sapiens]",2,2,2,2,1837,197.2,6.8,3.1,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","ZSWIM8","ENSG00000214655","","Regulation of expression of SLITs and ROBOs","",49.6,52.2,58,55.7,57.9,55.5,0.945002956830278,-0.08160925148200636,0.29889995177477874,0.5244741550308069,0.5002809910948494,0.30078599845469023,4665]
["High","A8CG34-1","Nuclear envelope pore membrane protein POM 121C [OS=Homo sapiens]",5,6,12,1,1229,125,10.37,18.15,"","","","","","","","",129.2,97.2,113.8,106.6,91.1,101.4,1.1374122367101303,0.18575523054403273,0.2543081320983361,0.5946397520186857,0.4527218183820812,0.3441685747015544,4386]
["Low","A8K2U0","Alpha-2-macroglobulin-like protein 1 [OS=Homo sapiens]",0,1,1,1,1454,161,5.73,0,"other biological processes","non-structural extracellular","enzyme regulator activity;other molecular function","A2ML1","ENSG00000166535","","","",79.6,88,79.4,59.4,81.7,72.8,1.1547452080411407,0.20757455930699567,0.1938175611867504,0.7126068754742404,0.38546294389866204,0.4140173660795924,3926]
["High","A8MQ14","Zinc finger protein 850 [OS=Homo sapiens]",8,4,5,4,1090,125.4,8.7,12.46,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF850","ENSG00000267041","","","Herpes simplex virus 1 infection",330.3,374.1,341.7,385.4,376.8,402.6,0.8980940934065934,-0.15506149070083558,0.05935960429457156,1.226509002831065,0.18749182456796712,0.7270176645892078,2472]
["Medium","A8MW92","PHD finger protein 20-like protein 1 [OS=Homo sapiens]",1,1,1,1,1017,114.9,6.83,2.1,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF20L1","ENSG00000129292","","","",94.5,93.6,81.9,111.4,100,86.7,0.9057363300905735,-0.14283696805297574,0.3176073922146004,0.49810939805649934,0.5182609233880042,0.2854515355107262,4785]
["High","A9UHW6","MIF4G domain-containing protein [OS=Homo sapiens]",18,4,5,4,222,25.4,5.33,10.69,"other biological processes","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","MIF4GD","ENSG00000125457","","","",111.7,108.9,122.9,138.3,125.2,140.4,0.850458034166873,-0.23368804699762402,0.03458576202540583,1.4611026511033292,0.13415083452278623,0.8724066213333483,2013]
["Medium","B0YJ81","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 [OS=Homo sapiens]",4,1,1,1,288,32.4,9.04,2.63,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","HACD1","ENSG00000165996","","Synthesis of very long-chain fatty acyl-CoAs","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism",35,44.4,34.4,31,33.8,37.3,1.1145935357492656,0.1565176914287806,0.3531172227251514,0.4520810999047941,0.5550914586345846,0.2556354552413821,4967]
["High","B2RTY4","unconventional myosin-IXa [OS=Homo sapiens]",4,9,9,8,2548,292.5,8.88,12.24,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","MYO9A","ENSG00000066933","","RHOA GTPase cycle; RHOB GTPase cycle; RHOV GTPase cycle","",296,319.9,333.3,299.2,278.4,285.3,1.10001158882837,0.13751872289279765,0.08293002642161389,1.081288196250872,0.22807948090875704,0.6419137841180937,2839]
["High","L0R6Q1","SLC35A4 upstream open reading frame protein [OS=Homo sapiens]",22,1,1,1,103,11.1,8.1,3.21,"stress response","other membranes","","SLC35A4","ENSG00000176087","","","",13.4,18.1,13.6,16.7,21.4,17.9,0.805357142857143,-0.31229939368958526,0.15617785158276445,0.8063805557174407,0.33873240698839585,0.4701432518260925,3600]
["High","O00115","Deoxyribonuclease-2-alpha [OS=Homo sapiens]",4,2,5,2,360,39.6,8.05,8.52,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","other cytoplasmic organelle","nucleic acid binding activity;other molecular function","DNASE2","ENSG00000105612","","Lysosome Vesicle Biogenesis","Lysosome",496.8,514.3,506.8,638,611.3,621.6,0.8113207547169811,-0.30165569986110136,2.2289556898922217E-4,3.6518985649098807,0.01200254208736446,1.9207267624862205,145]
["High","O00116","Alkyldihydroxyacetonephosphate synthase, peroxisomal [OS=Homo sapiens]",39,18,47,18,658,72.9,7.34,100.26,"other metabolic processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","AGPS","ENSG00000018510","Triacylglyceride synthesis","Plasmalogen biosynthesis; TYSND1 cleaves peroxisomal proteins","Ether lipid metabolism; Metabolic pathways; Peroxisome",1338.6,1365.9,1331.8,1369.3,1490.7,1442.4,{"$f":"AVERAGE(T66:V66)/AVERAGE(W66:Y66)","v":0.9381507995537376},{"$f":"LOG(Z66,2)","v":-0.09210825286936271},{"$f":"TTEST(T66:V66,W66:Y66,2,2)","v":0.0734992192930557},{"$f":"-LOG10(AB66)","v":1.1337172739568746},{"$f":"AB66*7808/AF66","v":0.21247016077015138},{"$f":"-LOG10(AD66)","v":0.6727020534856902},2701]
["High","O00139-2","Isoform 2 of Kinesin-like protein KIF2A [OS=Homo sapiens]",40,19,66,16,660,75,6.4,111.99,"","","","KIF2A","","","","",1861.9,1814.8,1946.9,1959.8,1793.9,1872.5,0.9995378763641536,-6.6685757490723768E-4,0.9894418230929245,0.004609736225135476,0.9954338042403755,1.9876150027059326E-3,7761]
["High","O00148","ATP-dependent RNA helicase DDX39A [OS=Homo sapiens]",49,19,142,7,427,49.1,5.68,236.83,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","other molecular function","DDX39A","ENSG00000123136","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",1678.6,1831.3,1632.5,1771.5,2006.7,1870.1,0.9104332276968292,-0.13537488285067842,0.13710283266894385,0.8629535721996731,0.3103795063726047,0.5081069619084284,3449]
["High","O00151","PDZ and LIM domain protein 1 [OS=Homo sapiens]",33,10,31,9,329,36,7.02,72.73,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PDLIM1","ENSG00000107438","","","",1256.7,1280.6,1331.1,1644.4,1293.6,1403.2,0.8910900211922971,-0.1663569094169884,0.210958666903759,0.6758026276124728,0.40460949918559325,0.39296392533323693,4071]
["High","O00154","cytosolic acyl coenzyme A thioester hydrolase [OS=Homo sapiens]",47,16,63,16,380,41.8,8.54,116.69,"other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","ACOT7","ENSG00000097021","","Mitochondrial Fatty Acid Beta-Oxidation","Fatty acid elongation; Biosynthesis of unsaturated fatty acids",2237.9,2388.9,2163.3,2074.2,2321.5,2140.6,1.0388293071003474,0.05495862052664459,0.4423135790899875,0.3542697275231713,0.6375455834474104,0.19548875845173863,5417]
["High","O00159-3","Isoform 3 of Unconventional myosin-Ic [OS=Homo sapiens]",19,17,24,17,1044,119.6,9.45,43.63,"","","","MYO1C","","","","",1243.3,1334.6,1300,1322.1,1346.8,1310.5,0.9744936422576268,-0.03727532173186631,0.30355612560764017,0.5177609988616818,0.504183413900118,0.29741144539129893,4701]
["High","O00161","Synaptosomal-associated protein 23 [OS=Homo sapiens]",67,13,35,13,211,23.3,5.01,82.87,"cell-cell signaling;cell organization and biogenesis;stress response;transport","plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP23","ENSG00000092531","Insulin signaling","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding","SNARE interactions in vesicular transport; Platelet activation",1388.7,1470.1,1413,1392.4,1305.7,1306.3,1.0667765457996203,0.09325801118769082,0.07661627257110858,1.1156789805332654,0.21745541847881342,0.6626297662643136,2751]
["High","O00165","HCLS1-associated protein X-1 [OS=Homo sapiens]",28,6,14,6,279,31.6,4.92,39.84,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HAX1","ENSG00000143575","","","",464.8,517,560.1,746.6,682.2,698.6,0.7247814233336467,-0.46438211633527665,4.396134020514625E-3,2.3569290761478316,0.04091181696326364,1.3881512323178964,839]
["High","O00170","AH receptor-interacting protein [OS=Homo sapiens]",32,8,21,8,330,37.6,6.29,43.43,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","AIP","ENSG00000110711","Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway","Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Cushing syndrome; Chemical carcinogenesis",685.6,687.6,655.2,851.4,767.7,742,0.8590911016051841,-0.2191169660090953,0.032885625822201905,1.4829938889866379,0.12935565058929596,0.8882145954271363,1985]
["High","O00178","GTP-binding protein 1 [OS=Homo sapiens]",29,15,40,15,669,72.4,8.34,104.63,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;other cytoplasmic organelle","nucleic acid binding activity;other molecular function","GTPBP1","ENSG00000100226","","","",1298.7,1320.8,1326.1,1233.9,1408.1,1317.5,0.9964894557393611,-0.005073555485865258,0.9319740217519761,0.030596193190018044,0.9650998888381206,0.015427734401156693,7540]
["High","O00180","potassium channel subfamily K member 1 [OS=Homo sapiens]",12,2,2,2,336,38.1,6.37,7.92,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","KCNK1","ENSG00000135750","","Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK); Phase 4 - resting membrane potential","",38.4,30.3,32.6,43.4,43.1,32.7,0.8498322147651008,-0.2347500616610231,0.23429670105520456,0.6302338263138659,0.4303431291082186,0.36618512662235336,4251]
["High","O00186","syntaxin-binding protein 3 [OS=Homo sapiens]",23,13,30,13,592,67.7,7.8,52.2,"cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STXBP3","ENSG00000116266","Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation","",1064.2,1056.8,1102.1,1077.7,1072.8,1093.8,0.9934654625034675,-9.458281354110953E-3,0.6701019589303309,0.17385911247538263,0.8103075879399138,0.09135009422258678,6457]
["High","O00189","AP-4 complex subunit mu-1 [OS=Homo sapiens]",8,3,4,3,453,49.9,7.2,3.41,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","AP4M1","ENSG00000221838","","Lysosome Vesicle Biogenesis","Lysosome",281.8,305.1,278.7,264.4,294.3,262.5,1.0540672187043352,0.07596687171821334,0.3264431772608529,0.48619240382143347,0.5276067745917491,0.2776896366493178,4831]
["High","O00192","armadillo repeat protein deleted in velo-cardio-facial syndrome [OS=Homo sapiens]",19,13,19,13,962,104.6,6.81,45.39,"cell adhesion;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","ARVCF","ENSG00000099889","22q11.2 copy number variation syndrome","","",811.7,769.3,782,684.6,618.1,656.2,1.2062892439634487,0.2705758780495151,0.004241579339681689,2.372472405011795,0.040046253306208736,1.3974381099057063,827]
["High","O00193","Small acidic protein [OS=Homo sapiens]",31,7,43,7,183,20.3,4.72,97.37,"","","","SMAP","ENSG00000110696","","","",1422.7,1451.1,1493,1795.8,1630.7,1591.8,0.870175158918359,-0.20062226235370062,0.02989709537035009,1.5243710031774187,0.12299079064894283,0.9101274066100571,1898]
["High","O00203-1","AP-3 complex subunit beta-1 [OS=Homo sapiens]",23,23,56,18,1094,121.2,6.04,99.11,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","AP3B1","ENSG00000132842","","Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions","Lysosome",2559.5,2708.3,2572.5,2462.5,2727,2615,1.0045870971875202,0.006602650415908701,0.9011576047618521,0.04519924798580037,0.9485358018307551,0.022946272319756295,7418]
["High","O00213","amyloid-beta A4 precursor protein-binding family B member 1 [OS=Homo sapiens]",9,5,6,5,710,77.2,5.06,9.96,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","APBB1","ENSG00000166313","Alzheimer's disease and miRNA effects; Alzheimer's disease","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks","Alzheimer disease",217.2,201.7,232.5,331.8,276.1,281.6,0.7323215289488475,-0.44945088575861913,0.016089622808948642,1.7934541370017998,0.08442726807276277,1.0735172635530243,1488]
["High","O00214-1","Galectin-8 [OS=Homo sapiens]",7,2,2,2,317,35.8,8.25,3.31,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","LGALS8","ENSG00000116977","","","",38.6,46.6,32,29.3,48.8,38.4,1.0060085836909871,0.008642614880605273,0.9751453823049593,0.01093063145431644,0.9871561188949983,0.00561415815820408,7713]
["High","O00217","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [OS=Homo sapiens]",16,3,5,3,210,23.7,6.34,9.73,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS8","ENSG00000110717","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",141.2,134.8,112.3,141.8,118.3,103,1.0694023684935279,0.09680477710827025,0.5881623168974583,0.23050280384756236,0.7510010417555772,0.12435946056123122,6115]
["High","O00220","Tumor necrosis factor receptor superfamily member 10A [OS=Homo sapiens]",7,3,5,3,468,50.1,7.03,2.26,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TNFRSF10A","ENSG00000104689","Apoptosis modulation and signaling","Cell surface interactions at the vascular wall; Regulation by c-FLIP; RIPK1-mediated regulated necrosis; CASP8 activity is inhibited; TP53 Regulates Transcription of Death Receptors and Ligands; Dimerization of procaspase-8; TRAIL  signaling","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; p53 signaling pathway; Apoptosis; Necroptosis; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Salmonella infection; Influenza A; Lipid and atherosclerosis",152.6,165.2,152,167.5,164.6,155.6,0.9632971088784087,-0.05394725902367107,0.3466642140214737,0.4600909880383092,0.5484810907962849,0.2608383403853294,4935]
["High","O00221","NF-kappa-B inhibitor epsilon [OS=Homo sapiens]",9,3,8,3,500,52.8,6.68,10.8,"other biological processes","cytosol;nucleus;other cell component","","NFKBIE","ENSG00000146232","TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19","Activation of NF-kappaB in B cells","Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Epstein-Barr virus infection; PD-L1 expression and PD-1 checkpoint pathway in cancer",165.4,183.1,136.3,164.8,125.5,143.7,1.1170506912442397,0.15969465614110936,0.3941168669756159,0.4043749782841419,0.593722650462205,0.22641638246503773,5183]
["High","O00231","26S proteasome non-ATPase regulatory subunit 11 [OS=Homo sapiens]",60,23,74,23,422,47.4,6.48,164.89,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD11","ENSG00000108671","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling pathway","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",3656.3,3667.6,3489.1,3495.4,3543,3551.2,1.0210961698270002,0.03011874985787487,0.28425526194551304,0.5462914871934417,0.4844935789719637,0.31471197431088993,4581]
["High","O00232-1","26s proteasome non-atpase regulatory subunit 12 [OS=Homo sapiens]",51,20,144,20,456,52.9,7.65,244.33,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","","PSMD12","ENSCANG00000030312; ENSCATG00000032968; ENSCSAG00000004164; ENSG00000197170; ENSMFAG00000032701; ENSMLEG00000034943; ENSMMUG00000002132; ENSMNEG00000032475; ENSNLEG00000001265; ENSPANG00000020562; ENSPPYG00000008565; ENSRROG00000042400","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease","Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",4491.9,4648.7,4265.7,3854.9,4510.4,4193.6,1.0674740622188248,0.09420101526694229,0.2675545243797982,0.5725877006547168,0.46714349873825234,0.3305496908744482,4472]
["High","O00233-1","26S proteasome non-ATPase regulatory subunit 9 [OS=Homo sapiens]",33,7,19,7,223,24.7,6.95,43.16,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMD9","ENSG00000110801","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",677.1,688.3,652.5,734.2,585.2,563.8,1.0715271877655055,0.09966845585380185,0.45725585234248506,0.3398407273522948,0.6489010714449516,0.18782150874732412,5502]
["Medium","O00244","Copper transport protein ATOX1 [OS=Homo sapiens]",12,1,3,1,68,7.4,7.24,6.45,"stress response;transport;other biological processes","cytosol","other molecular function","ATOX1","ENSG00000177556","Copper homeostasis","Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface","Mineral absorption",174.3,195.2,159.1,163.2,177.2,150.1,1.0776758409785934,0.10792328853496888,0.3861040375078389,0.4132956569146533,0.5865175729301957,0.23171897125129368,5140]
["High","O00255-2","Isoform 2 of Menin [OS=Homo sapiens]",26,12,20,12,610,67.5,6.55,48.24,"","","","MEN1","","","","",729,741.4,771.2,651.7,655.2,683.1,1.1264321608040202,0.17176043011244468,0.006311609284743048,2.199859893628184,0.05003151806626774,1.30075631946716,985]
["High","O00258-1","Tail-anchored protein insertion receptor WRB [OS=Homo sapiens]",13,2,2,2,174,19.8,9.67,2.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus","","GET1; WRB","ENSANAG00000014374; ENSCANG00000035340; ENSCATG00000041953; ENSCCAG00000026562; ENSCSAG00000008355; ENSG00000182093; ENSMLEG00000038301; ENSMNEG00000036276; ENSNLEG00000033928; ENSPANG00000032093; ENSPPAG00000034665; ENSPPYG00000011427; ENSPTRG00000013915; ENSSBOG00000020756","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",22,21.7,22.8,21.8,22.1,26.9,0.9392655367231637,-0.09039501969444572,0.44278392584909243,0.35380815347025957,0.6376349858040785,0.19542786205609092,5422]
["High","O00264","Membrane-associated progesterone receptor component 1 [OS=Homo sapiens]",69,19,142,17,195,21.7,4.7,283.11,"other metabolic processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PGRMC1","ENSG00000101856","","Neutrophil degranulation","",5670.3,5779.2,5408.7,5674.1,5034.1,5108.3,1.0658616002276105,0.09202011949672025,0.2057428761929456,0.6866751932172959,0.39862044102097255,0.39944043469976986,4030]
["High","O00267","Transcription elongation factor Spt5 [OS=Homo sapiens]",34,28,82,28,1087,120.9,5.06,189.56,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SUPT5H","ENSG00000196235","Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","",3043.5,3162.5,3060.1,3172.1,3275.1,3277.1,0.9528809271618525,-0.06963214992938001,0.03982217333083333,1.3998750416508583,0.1464585630556508,0.8342852311582217,2123]
["High","O00268","Transcription initiation factor TFIID subunit 4 [OS=Homo sapiens]",10,7,11,7,1085,110,9.94,32.34,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","TAF4","ENSG00000130699","","RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors; Huntington disease",338.8,325.1,337.1,348.2,320.8,347.9,0.9843642442718066,-0.022735840127258745,0.6260021077604792,0.2034242045096914,0.7810521664100065,0.10731995866123054,6258]
["High","O00273-1","DNA fragmentation factor subunit alpha [OS=Homo sapiens]",56,13,36,4,331,36.5,4.79,78.92,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DFFA","ENSG00000160049","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis","Apoptosis induced DNA fragmentation","Apoptosis",794.9,742.3,847.6,744.4,711.5,761.7,1.0753968253968251,0.10486911785395474,0.17426303271950713,0.7587947321595918,0.3612014227432736,0.442250547704224,3767]
["High","O00291","Huntingtin-interacting protein 1 [OS=Homo sapiens]",38,32,79,31,1037,116.1,5.3,156.45,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HIP1","ENSG00000127946","","Clathrin-mediated endocytosis; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","Huntington disease; Pathways of neurodegeneration",3607.2,3555.2,3648.9,3797.6,3702.9,3812.3,0.9556696838978856,-0.0654160412724943,0.018693422533705806,1.7283111774106437,0.0920291570890132,1.036074555733593,1586]
["High","O00299","chloride intracellular channel protein 1 [OS=Homo sapiens]",87,18,146,17,241,26.9,5.17,373.46,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion;nucleus;other cell component","transporter activity","CLIC1","ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685","VEGFA-VEGFR2 signaling pathway","","",5863,6098.9,5648.4,5656.5,5913.6,5562.1,1.0279065152169597,0.03970906203597187,0.3944935775858201,0.4039600627758363,0.5941755119193833,0.22608525097973786,5184]
["Medium","O00300","Tumor necrosis factor receptor superfamily member 11B [OS=Homo sapiens]",2,1,1,1,401,46,8.29,2.13,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","TNFRSF11B","ENSG00000164761","Osteoclast signaling; RANKL/RANK signaling pathway; Ectoderm differentiation; Vitamin D receptor pathway; Osteoblast signaling; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Overlap between signal transduction pathways contributing to LMNA laminopathies; Monoamine transport","TNFs bind their physiological receptors","Cytokine-cytokine receptor interaction; Osteoclast differentiation",76.4,99.3,85.5,103.7,118.2,107.3,0.7934386391251519,-0.3338094388751949,0.04646122379458906,1.3329093550128124,0.16073072015425402,0.7939011094319391,2257]
["High","O00303","Eukaryotic translation initiation factor 3 subunit F [OS=Homo sapiens]",42,11,55,11,357,37.5,5.45,110.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3F","ENSG00000175390","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",2171.7,2138.7,2126.9,2060.7,2239.1,2138.9,0.9997825648034541,-3.1372678863067754E-4,0.9934387015135998,2.8589251477205316E-3,0.9975269266227093,1.0753724073033022E-3,7776]
["High","O00308","NEDD4-like E3 ubiquitin-protein ligase WWP2 [OS=Homo sapiens]",14,10,14,9,870,98.9,7.12,23.19,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","WWP2","ENSG00000198373","","RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle","Ubiquitin mediated proteolysis",404.3,408.4,426.6,474.3,481.6,440.9,0.8872422680412372,-0.17259999805216344,0.021271195654435613,1.6722080977075486,0.09915551980288553,1.0036831044217773,1675]
["High","O00311-1","Cell division cycle 7-related protein kinase [OS=Homo sapiens]",5,2,5,2,574,63.8,8.73,10.07,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CDC7","ENSG00000097046","Cell cycle; Retinoblastoma gene in cancer; DNA replication","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Transcriptional Regulation by E2F6","Cell cycle",38.9,49.4,43.6,46.7,52.5,46.3,0.9065292096219931,-0.14157458854410152,0.2807138061329343,0.5517362272661637,0.48097726536887225,0.317875451189977,4557]
["High","O00330-1","Pyruvate dehydrogenase protein X component, mitochondrial [OS=Homo sapiens]",24,11,21,11,501,54.1,8.66,44.04,"other metabolic processes","mitochondrion;other cell component","other molecular function","PDHX","ENSG00000110435","Amino acid metabolism","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Metabolic pathways",863.7,824.3,869,868.8,867.3,901.7,0.9693684130714989,-0.04488302192250978,0.20937297634106355,0.6790793731983349,0.4027554075563006,0.39495861985698494,4059]
["Low","O00339-1","Matrilin-2 [OS=Homo sapiens]",1,1,2,1,956,106.8,6.27,3.59,"","non-structural extracellular;extracellular matrix","extracellular structural activity;other molecular function","MATN2","ENSG00000132561","","","",141.6,173.4,158.1,164.7,171.6,148.3,0.9762690879075527,-0.03464924393967984,0.7554532939096451,0.12179238086080929,0.8648943282766142,0.06303695085865282,6820]
["High","O00391","Sulfhydryl oxidase 1 [OS=Homo sapiens]",3,2,2,2,747,82.5,8.92,3.63,"cell organization and biogenesis;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","QSOX1","ENSG00000116260","","Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",166.6,171.1,173.7,134.4,154.5,138.7,1.195977549111319,0.2581903075211582,0.01236252221121688,1.9078929151156732,0.07279530424221825,1.1378966345257921,1326]
["High","O00399","Dynactin subunit 6 [OS=Homo sapiens]",22,4,8,4,190,20.7,6.32,12.06,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","DCTN6","ENSG00000104671","","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","Vasopressin-regulated water reabsorption; Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection",420.2,419.9,397.8,470.6,444.7,457.9,0.9014710166035537,-0.1496469868953061,0.012825210135843437,1.8919355104196849,0.07417721536345596,1.1297294742560557,1350]
["High","O00400","Acetyl-coenzyme A transporter 1 [OS=Homo sapiens]",12,6,10,6,549,60.9,7.33,16.81,"transport;signal transduction","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC33A1","ENSG00000169359","Ganglio sphingolipid metabolism","Transport of vitamins, nucleosides, and related molecules; Defective SLC33A1 causes spastic paraplegia 42 (SPG42)","Glycosphingolipid biosynthesis; Metabolic pathways",383,423.4,360.1,382.2,399.6,376.2,1.0073402417962003,0.01055105399496258,0.8930800212649386,0.049109625952661995,0.9435952376233614,0.025214259688852315,7390]
["High","O00401","Neural Wiskott-Aldrich syndrome protein [OS=Homo sapiens]",30,10,24,10,505,54.8,7.93,39.06,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity","WASL","ENSG00000106299","Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 signaling pathway","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle; RHOV GTPase cycle; NOSTRIN mediated eNOS trafficking; Nephrin family interactions; EPHB-mediated forward signaling; DCC mediated attractive signaling","Endocytosis; Adherens junction; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",805.4,712.4,738.9,892.9,804.1,819,0.8969395866454689,-0.1569172791766989,0.09084519857138146,1.041698021455106,0.24110105725538628,0.6178008851879819,2942]
["High","O00410","Importin-5 [OS=Homo sapiens]",64,47,286,44,1097,123.6,4.94,616.8,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","IPO5","ENSG00000065150","","vRNP Assembly","Nucleocytoplasmic transport",8459.9,8616.5,8485.3,8759.2,8957.6,8917.8,0.9597178106673275,-0.05931782759258542,0.009980084968031199,2.0008657612186407,0.0653729055624057,1.1846022119642228,1192]
["High","O00411","DNA-directed RNA polymerase, mitochondrial [OS=Homo sapiens]",17,16,27,16,1230,138.5,8.98,50.34,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","POLRMT","ENSG00000099821","Mitochondrial gene expression","Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis","",639.9,612.5,638.5,582.7,660.3,615.7,1.01732393608436,0.024779135015729082,0.6801388383945195,0.16740242465562194,0.8167523916001859,0.08790958515709439,6502]
["High","O00418","Eukaryotic elongation factor 2 kinase [OS=Homo sapiens]",10,7,10,7,725,82.1,5.33,18.04,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;kinase activity;other molecular function","EEF2K","ENSG00000103319","Translation factors; AMP-activated protein kinase (AMPK) signaling; BDNF-TrkB signaling","mTORC1-mediated signalling","AMPK signaling pathway; Oxytocin signaling pathway",347.2,330.4,335.3,368.9,357.8,368.5,0.9248539079620159,-0.11270260266857106,0.011292944892624456,1.9471927911269056,0.07025921412080618,1.153296712285327,1255]
["High","O00422","Histone deacetylase complex subunit SAP18 [OS=Homo sapiens]",60,10,53,10,153,17.6,9.35,91.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SAP18","ENSG00000150459","Hedgehog signaling pathway","Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression","Nucleocytoplasmic transport; mRNA surveillance pathway",3744,3592.1,4055.8,3877.3,3810.1,3792.1,0.9923690056187118,-0.011051418240719686,0.843796684850571,0.07376218522805576,0.9175995146675847,0.03734682481172072,7180]
["High","O00423-1","Echinoderm microtubule-associated protein-like 1 [OS=Homo sapiens]",5,4,7,4,815,89.8,7.06,15.94,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","EML1","ENSG00000066629","","","",184.8,190,174.8,184.5,206.8,199.1,0.9308943089430896,-0.10331071724229575,0.16090239381531557,0.7934374946638744,0.3446710263127528,0.46259522265923236,3645]
["High","O00425","Insulin-like growth factor 2 mRNA-binding protein 3 [OS=Homo sapiens]",56,30,200,24,579,63.7,8.87,408.36,"protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP3","ENSG00000136231","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",7907.5,8014,7809.8,8854.6,9176.2,9095.9,0.8748318077761024,-0.19292241898397733,0.000562526037300824,3.249857370826613,0.01709028521106939,1.7672506894992723,257]
["High","O00429","Dynamin-1-like protein [OS=Homo sapiens]",73,46,289,1,736,81.8,6.81,653.37,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","DNM1L","ENSG00000087470","Synaptic vesicle pathway; CAMKK2 pathway","Apoptotic execution phase","Necroptosis; NOD-like receptor signaling pathway; TNF signaling pathway",89.3,82.5,93.6,88.2,97.8,104.9,0.912341010656583,-0.13235492573011304,0.21785195705703514,0.6618385342581633,0.4120610660613688,0.38503841821868284,4128]
["High","O00429-6","Isoform 6 of Dynamin-1-like protein [OS=Homo sapiens]",71,46,287,0,749,83.3,7.08,646.88,"","","","DNM1L","","","","",10449.8,10407.7,10213.6,10282.3,10316.3,10517.7,0.998547385132551,-2.0972038493781934E-3,0.8911741654254128,0.05003741190981175,0.942729695656635,0.02561281257839349,7381]
["High","O00429-8","Isoform 8 of Dynamin-1-like protein [OS=Homo sapiens]",72,46,285,1,738,82,6.96,642.25,"","","","DNM1L","","","","",216.5,204.2,221,172.6,214.5,194.9,1.102577319587629,0.14087983009055435,0.2034731111601383,0.6914929743814703,0.3957942331685002,0.40253053787430165,4014]
["High","O00442","RNA 3'-terminal phosphate cyclase [OS=Homo sapiens]",44,14,50,14,366,39.3,7.85,106.23,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RTCA","ENSG00000137996","","","",1617.5,1731.8,1618.1,1698.9,1737.8,1758,0.9562438639382448,-0.06454950970505535,0.1438999845917393,0.8419392525659866,0.3206538469441497,0.4939635454033942,3504]
["High","O00443","phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [OS=Homo sapiens]",15,23,41,23,1686,190.6,8.02,76.67,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2A","ENSG00000011405","Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection",1747.1,1719.5,1753.4,2047.1,1971.5,1967.8,0.8719764800213818,-0.19763887343348546,7.8502718565355556E-4,3.1051153032867327,0.018918186004885686,1.7231205088347095,324]
["High","O00458","Interferon-related developmental regulator 1 [OS=Homo sapiens]",11,3,3,3,451,50.2,7.18,9.27,"other biological processes","nucleus","","IFRD1","ENSG00000006652","Hypertrophy model","","",20.5,31,18.1,39.4,32.3,33.3,0.6628571428571429,-0.5932301167047566,0.060110753365615784,1.2210478290022784,0.18871924498541537,0.7241838096135789,2487]
["High","O00459","Phosphatidylinositol 3-kinase regulatory subunit beta [OS=Homo sapiens]",16,7,14,7,728,81.5,6.43,30.92,"other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R2","ENSG00000105647","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway","Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOU GTPase cycle; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",389,383.9,395.4,396.6,400.4,406.5,0.9707519734108849,-0.042825359941656364,0.05608926130790301,1.2511202795842444,0.18067035985647964,0.7431130904198576,2424]
["High","O00461","Golgi integral membrane protein 4 [OS=Homo sapiens]",32,17,34,17,696,81.8,4.77,79.63,"","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","GOLIM4","ENSG00000173905","","Intra-Golgi traffic","",1251.2,1112.7,1256.2,1261.9,1231.9,1193.5,0.9817752827271987,-0.026535249160967136,0.6832979293395883,0.16538989535773616,0.8185317938452755,0.08696444682822613,6518]
["High","O00462","Beta-mannosidase [OS=Homo sapiens]",8,7,11,6,879,100.8,5.52,16.56,"protein metabolism;other metabolic processes","plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","MANBA","ENSG00000109323","","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","Other glycan degradation; Lysosome",311.4,329.9,308.9,260.6,279.6,292.4,1.1412442949795818,0.19060764827062535,0.026085185805302738,1.583606065442266,0.11378387193732054,0.9439192917635237,1790]
["High","O00463","TNF receptor-associated factor 5 [OS=Homo sapiens]",4,2,4,2,557,64.4,7.43,1.67,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","signal transduction activity or receptor binding;other molecular function","TRAF5","ENSG00000082512","RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Small cell lung cancer; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling","","NF-kappa B signaling pathway; Necroptosis; NOD-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Shigellosis; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Small cell lung cancer",27.8,37.3,25.6,30.9,29.2,26.8,1.0437284234752588,0.061746373714122164,0.7545017432882495,0.12233975244294078,0.8648193792710881,0.06307458707486878,6812]
["High","O00468","Agrin [OS=Homo sapiens]",18,26,37,26,2067,217.1,6.39,78.62,"","","","","","","","",1303.4,1266.4,1360.2,1385.7,1285.8,1387.8,0.9681472175005542,-0.04670165295666498,0.37610523514496225,0.4246906214333693,0.5779629356449253,0.23810001168502953,5081]
["High","O00469-1","procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [OS=Homo sapiens]",13,7,15,7,737,84.6,6.71,30.91,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","PLOD2","ENSG00000152952","Clear cell renal cell carcinoma pathways; Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","Lysine degradation; Metabolic pathways",734,732.7,717.4,638.9,696.8,662.7,1.0929243394715773,0.12819353015224122,0.024636349512050192,1.608423643269962,0.10917174630538473,0.9618897426873556,1762]
["High","O00471","Exocyst complex component 5 [OS=Homo sapiens]",20,15,29,15,708,81.8,6.71,45.03,"cell organization and biogenesis;transport;other biological processes","cytosol;other cell component","other molecular function","EXOC5","ENSG00000070367","Ciliary landscape","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium","Salmonella infection",1279.3,1248.3,1270.8,1355.9,1351.7,1366,0.932443047918303,-0.10091248425945155,8.3832562331219581E-4,3.076587259484813,0.019539243184542164,1.709092261863023,335]
["High","O00483","Cytochrome c oxidase subunit NDUFA4 [OS=Homo sapiens]",56,5,13,5,81,9.4,9.38,22.67,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NDUFA4","ENSG00000189043","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; Oxidative phosphorylation","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",571.2,590.4,548.9,518.8,593.4,600.4,0.9987737942309938,-1.7701264736317134E-3,0.9817308094290391,8.007579429106253E-3,0.9908679110679858,0.003984235845416084,7736]
["High","O00487","26S proteasome non-ATPase regulatory subunit 14 [OS=Homo sapiens]",41,12,33,12,310,34.6,6.52,69.71,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMD14","ENSG00000115233","Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Metalloprotease DUBs","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",1813.8,1849,1718.7,1671.6,1828.8,1808.4,1.013694243520193,0.0196225637060806,0.7194420553960026,0.14300417884364192,0.8442145429113298,0.07354717071781018,6654]
["High","O00499","Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",35,15,33,1,593,64.7,5.06,96.43,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","BIN1","ENSG00000136717","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway","Clathrin-mediated endocytosis","Endocytosis; Fc gamma R-mediated phagocytosis",1552.2,1487.2,1586,1855.3,1753.5,1732.3,{"$f":"AVERAGE(T130:V130)/AVERAGE(W130:Y130)","v":0.8660013854823911},{"$f":"LOG(Z130,2)","v":-0.20755876182107114},{"$f":"TTEST(T130:V130,W130:Y130,2,2)","v":0.00752034196287002},{"$f":"-LOG10(AB130)","v":2.1237624108430846},{"$f":"AB130*7808/AF130","v":0.05529080042004624},{"$f":"-LOG10(AD130)","v":1.2573471229298996},1062]
["High","O00499-2","Isoform IIB of Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",39,15,35,1,518,56.5,5.12,96.18,"","","","BIN1","","","","",257.7,221.6,244.9,283.5,265.6,281.5,0.8718998314471466,-0.1977656949486175,0.0416238538815361,1.3806577116784708,0.1503928973193123,0.8227726739030768,2161]
["High","O00505","Importin subunit alpha-4 [OS=Homo sapiens]",34,14,51,10,521,57.8,4.94,112.11,"cell organization and biogenesis;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","KPNA3","ENSG00000102753","","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis",1009.9,1025.4,1092.8,1120.9,1134.3,1132.4,0.9233970952887,-0.11497690074913969,0.02845738980210069,1.5458049372289346,0.11939564727286522,0.9230115057010663,1861]
["High","O00506","serine/threonine-protein kinase 25 [OS=Homo sapiens]",19,6,24,2,426,48.1,6.74,36.62,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","kinase activity;other molecular function","STK25","ENSG00000115694","","","",51.5,61.8,56.4,58.1,53.1,60.4,0.9889277389277389,-0.016062987956882293,0.8714736145001859,0.05974575743573479,0.9310982460341339,0.031004491457599617,7308]
["High","O00507-1","Probable ubiquitin carboxyl-terminal hydrolase FAF-Y [OS=Homo sapiens]",14,31,68,5,2555,290.9,5.86,132.56,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","USP9Y","ENSG00000114374","","","",49.5,66.1,63.7,78.7,83.5,81.3,0.7363449691991787,-0.4415462841013296,0.01625497053805877,1.7890138133207365,0.08500924980653911,1.0705338163871265,1493]
["High","O00515","Ladinin-1 [OS=Homo sapiens]",14,6,8,6,517,57.1,9.67,18.53,"","extracellular matrix;cytoskeleton","other molecular function","LAD1","ENSG00000159166","","","",415.4,357.7,392.1,511.1,401.9,409.8,0.880858784396734,-0.1830173440507666,0.24869572506417675,0.6043316799371216,0.4469082212430592,0.3497816560631714,4345]
["High","O00522","Krev interaction trapped protein 1 [OS=Homo sapiens]",1,1,1,1,736,84.3,8.41,3.49,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","KRIT1","ENSG00000001631","","","Rap1 signaling pathway",82.3,75.9,79.7,94.1,96.4,104.6,0.8061674008810572,-0.31084864900687265,0.006657950953485208,2.176659408444775,0.05167522966681163,1.286717584506048,1006]
["High","O00534","von Willebrand factor A domain-containing protein 5A [OS=Homo sapiens]",10,6,8,6,786,86.4,6.58,19.04,"","nucleus","","VWA5A","ENSG00000110002","","","",297.4,319,335.9,247.7,275.1,271.1,1.1995213502960071,0.26245883640754347,0.019768177816307398,1.7040333610755352,0.09533658578735527,1.0207404051702735,1619]
["High","O00541-1","Pescadillo homolog [OS=Homo sapiens]",35,19,77,19,588,68,7.33,173.63,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PES1","ENSG00000100029","","Major pathway of rRNA processing in the nucleolus and cytosol","",4459.8,4428.6,4386,4460.2,4686.2,4639.3,0.9629108423946553,-0.054525872301301986,0.07735451972970007,1.1115143059294155,0.21859720957274634,0.6603553861872914,2763]
["Medium","O00559","Receptor-binding cancer antigen expressed on SiSo cells [OS=Homo sapiens]",8,1,1,1,213,24.4,6.29,2.55,"other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","EBAG9","ENSG00000147654","","Estrogen-dependent gene expression","Estrogen signaling pathway",22.9,17.3,23.4,23.7,20.2,21.4,0.9739663093415007,-0.038056226262075436,0.8101620896454681,0.09142808285446052,0.8970144066863038,0.04720058182310956,7052]
["High","O00560-1","Syntenin-1 [OS=Homo sapiens]",40,7,14,7,298,32.4,7.53,38.76,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SDCBP","ENSG00000137575; ENSPPAG00000038846; ENSPTRG00000020277","Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling pathway","Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death","",556.4,559.7,535.5,389.1,386.7,419,1.382323401406093,0.4670951808653865,2.9120406161286573E-4,3.535802571928527,0.013534055434959854,1.8685720489957547,168]
["High","O00562","Membrane-associated phosphatidylinositol transfer protein 1 [OS=Homo sapiens]",8,7,7,6,1244,134.8,5.95,14.49,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","PITPNM1","ENSG00000110697","","Synthesis of PI","",365.9,384.9,373.8,390.7,389.6,367.5,0.9797874194110472,-0.029459327526464556,0.4547855290579456,0.3421933626964127,0.6466882919112072,0.1893050017471542,5491]
["High","O00566","U3 small nucleolar ribonucleoprotein protein Mpp10 [OS=Homo sapiens]",24,16,43,16,681,78.8,4.86,96.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","MPHOSPH10","ENSG00000124383","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1141.8,1089.5,1182.5,1363.4,1325.9,1368.7,0.8412518482010842,-0.24939032561004232,2.0413047381555105E-3,2.690092156371551,0.029138039114292916,1.5355396780463466,547]
["High","O00567","Nucleolar protein 56 [OS=Homo sapiens]",61,28,124,28,594,66,9.19,275.69,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP56","ENSG00000101361","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","Ribosome biogenesis in eukaryotes; Spinocerebellar ataxia",4764.5,4903.4,4893.8,4958,5241.8,5392.4,0.9339092623234696,-0.09864570893008252,0.06367443949051217,1.1960348693286036,0.19558222798659286,0.7086706108879576,2542]
["High","O00571","ATP-dependent RNA helicase DDX3X [OS=Homo sapiens]",66,41,252,13,662,73.2,7.18,546.44,"cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","DDX3X","ENSG00000215301","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Hepatitis B infection","Neutrophil degranulation","RIG-I-like receptor signaling pathway; Hepatitis B; Viral carcinogenesis",13800.7,14006.1,13637.8,14661.8,14809,15023.9,0.9314502626155476,-0.10244936038890325,2.4540100014006434E-3,2.6101236716235787,0.030904693695058424,1.5099755564631971,620]
["High","O00592","Podocalyxin [OS=Homo sapiens]",22,10,69,10,558,58.6,5.49,125.4,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","","PODXL","ENSG00000128567","Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Malignant pleural mesothelioma","","Salmonella infection",3261,3238.6,3354.7,3975.4,3680.7,3931,0.8504543846173761,-0.23369423801240244,0.004204235049028693,2.376313011568024,0.03983818842574762,1.3997004186065043,824]
["High","O00622","Protein CYR61 [OS=Homo sapiens]",23,8,17,8,381,42,8.21,29.16,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi","signal transduction activity or receptor binding;other molecular function","CCN1","ENSG00000142871","Oncostatin M signaling pathway; VEGFA-VEGFR2 signaling pathway; Hypertrophy model","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",1086.6,1167.3,1057.5,403,410.3,441.8,2.638355509521154,1.3996389759868733,3.9790247958153877E-5,4.4002233544821,7.0609603649378514E-3,2.1511362263096525,44]
["High","O00625","Pirin [OS=Homo sapiens]",27,8,29,8,290,32.1,6.92,33.91,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PIR","ENSG00000087842","","Digestion","",1675.8,1718.2,1703.7,1883.2,1843.9,1873.2,0.9102548077781547,-0.13565763917979812,6.1417702935296367E-4,3.211706430504162,0.017630493548485077,1.7537355298797253,272]
["High","O00629","Importin subunit alpha-3 [OS=Homo sapiens]",43,16,92,12,521,57.9,4.96,245.96,"transport","other membranes;cytosol;nucleus","other molecular function","KPNA4","ENSG00000186432","Leptin signaling pathway","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis",3738.5,3583,3644.2,3567.3,3593.8,3562.5,1.0225763736058786,0.03220859838235902,0.15603163578768656,0.8067873384718456,0.33869752911600126,0.4701879716317213,3597]
["Low","O00635","E3 ubiquitin-protein ligase TRIM38 [OS=Homo sapiens]",2,1,2,1,465,53.4,7.02,0,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM38","ENSG00000112343","","Interferon gamma signaling","",77.3,74,76.6,84.8,86,81.6,0.902931854199683,-0.1473109857172519,0.00781298122479264,2.1071832193329105,0.056747681305284584,1.2460518789258994,1075]
["High","O00743","Serine/threonine-protein phosphatase 6 catalytic subunit [OS=Homo sapiens]",31,8,22,8,305,35.1,5.69,47.21,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","cytosol;mitochondrion;nucleus","other molecular function","PPP6C","ENSG00000119414","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",939.9,968,946,910,1014.3,973.4,0.9848845636194224,-0.021973455854692795,0.6672898206012678,0.17568550019106602,0.808660394110616,0.09223382687877696,6443]
["High","O00746","Nucleoside diphosphate kinase, mitochondrial [OS=Homo sapiens]",34,6,16,6,187,20.6,10.29,30.44,"other metabolic processes;transport","other membranes;mitochondrion","kinase activity;other molecular function","NME4","ENSG00000103202","Pyrimidine metabolism","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",1032.9,1077.1,957.4,909.8,1007.6,992.8,1.0540169060545668,0.0758980074736833,0.32136553890274977,0.4930006959198697,0.5223193438286158,0.28206388999210275,4804]
["High","O00750","Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [OS=Homo sapiens]",2,3,4,3,1634,184.7,7.3,10.18,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2B","ENSG00000133056","Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)","Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection",114.2,110.3,97.8,102.4,120.3,115.9,0.9518606024808033,-0.07117778483609662,0.4987236110391868,0.3021400705197634,0.684966394897796,0.16433073488488162,5685]
["High","O00754","Lysosomal alpha-mannosidase [OS=Homo sapiens]",9,8,12,8,1011,113.7,7.28,23.14,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MAN2B1","ENSG00000104774","","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","Other glycan degradation; Lysosome",672.8,668.3,670.5,626.3,597.1,558.6,1.1288439955106622,0.1748461216695,0.01761156871481208,1.754201958408438,0.08940905625829175,1.0486184892152148,1538]
["High","O00762","Ubiquitin-conjugating enzyme E2 C [OS=Homo sapiens]",23,4,9,4,179,19.6,7.37,12.57,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","UBE2C","ENSG00000175063","Gastric cancer network 1; Gastric cancer network 2","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Ubiquitin mediated proteolysis",575.3,622.3,541.4,512.3,437.1,381.8,1.3063401442307692,0.38553059405285733,0.0378576191974349,1.4218467015694791,0.14238549648052584,0.8465342460872639,2076]
["High","O00763","Acetyl-CoA carboxylase 2 [OS=Homo sapiens]",3,6,16,1,2458,276.4,6.49,36.48,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","ACACB","ENSG00000076555","AMP-activated protein kinase (AMPK) signaling; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; IL-18 signaling pathway; 7q11.23 copy number variation syndrome","ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP)","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; AMPK signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Glucagon signaling pathway; Insulin resistance; Alcoholic liver disease",47.3,47.8,54.8,47.5,52.8,48.9,1.0046916890080428,6.7528476926217405E-3,0.9396129661096385,0.027050998843117843,0.9695385277367593,0.01343492815204961,7567]
["High","O00764-1","Pyridoxal kinase [OS=Homo sapiens]",40,11,42,11,312,35.1,6.13,76.73,"other metabolic processes","non-structural extracellular;nucleus;other cell component","kinase activity;other molecular function","HEL-S-1a; PDXK","ENSG00000160209","","Neutrophil degranulation; Vitamins B6 activation to pyridoxal phosphate","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors",986,1033.6,986.9,992.4,961.7,949.1,1.0355814273904658,0.05044099660409593,0.16521631965660813,0.781947056369418,0.34969070856025924,0.45631590693758595,3689]
["High","O00767","acyl-CoA desaturase [OS=Homo sapiens]",11,3,19,3,359,41.5,9,30.34,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","SCD","ENSG00000099194","Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Adipogenesis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; AMPK signaling pathway; Alcoholic liver disease",907,848.9,975.6,987.5,814.8,1002.5,0.9738662293211636,-0.03820447817418142,0.7463111376889282,0.12708007707081553,0.8597222430031206,0.06564183691353956,6778]
["High","O14494","Phospholipid phosphatase 1 [OS=Homo sapiens]",11,2,2,2,284,32.1,7.97,6.23,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","PLPP1","ENSG00000067113","Androgen receptor signaling pathway; Androgen receptor signaling pathway; Sphingolipid pathway; Triacylglyceride synthesis; Androgen receptor signaling pathway","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",119.1,122.1,125.3,115.4,125.2,117.1,1.0246016214705058,0.035063080025948504,0.45076526398999606,0.34604955810664123,0.6435500422808355,0.1914176768226446,5469]
["High","O14495","Phospholipid phosphatase 3 [OS=Homo sapiens]",10,3,5,3,311,35.1,9.14,8.06,"cell adhesion;cell-cell signaling;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","PLPP3","ENSG00000162407","Triacylglyceride synthesis; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",211.4,215.9,201.5,257.7,268.4,268.4,0.7914411579609818,-0.33744600197727487,5.7288980387177767E-4,3.241928907130085,0.017337688328026513,1.7610088084346798,258]
["High","O14497","AT-rich interactive domain-containing protein 1A [OS=Homo sapiens]",28,46,118,45,2285,241.9,6.7,267.26,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ARID1A","ENSG00000117713","Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",5023.6,4657.1,5028.1,5431.1,5127.7,5232.3,0.931461392809874,-0.10243212127172653,0.07620480811900607,1.1180176261187194,0.2167603430940617,0.6640201702461948,2745]
["High","O14524-1","Nuclear envelope integral membrane protein 1 [OS=Homo sapiens]",9,5,9,5,444,50.6,6.93,16.27,"cell organization and biogenesis","other membranes;nucleus","","NEMP1","ENSG00000166881","","","",390.3,354.3,376.1,427.9,421.3,427.6,0.8777412280701753,-0.18813242164848498,0.00822940107099485,2.0846317712308786,0.05836072984770915,1.233879285543995,1101]
["High","O14530","Thioredoxin domain-containing protein 9 [OS=Homo sapiens]",36,7,21,7,226,26.5,5.88,38,"","cytosol;cytoskeleton;nucleus;other cell component","","TXNDC9","ENSG00000115514","","","",766.1,795.6,795.9,715.7,637.5,653.4,1.174922754908801,0.23256591017473155,0.010577879151466345,1.9756013989497736,0.067587627180564,1.1701328001976736,1222]
["High","O14531","dihydropyrimidinase-related protein 4 [OS=Homo sapiens]",21,10,33,10,572,61.8,7.09,65.86,"cell organization and biogenesis;developmental processes;other biological processes","cytosol","cytoskeletal activity;other molecular function","DPYSL4","ENSG00000151640","","CRMPs in Sema3A signaling","",953.8,975.8,886.2,915.3,907.5,949.5,1.0156909425386862,0.022461481346205927,0.6529181377480215,0.1851412667386711,0.7980564839600113,0.09796636954648104,6388]
["High","O14545","TRAF-type zinc finger domain-containing protein 1 [OS=Homo sapiens]",6,3,6,3,582,64.8,5.29,11.48,"other biological processes","","other molecular function","TRAFD1","ENSG00000135148","","","",382.8,344,331.4,331.1,285.1,294.4,1.162090929057764,0.21672295838813985,0.07807745410298589,1.1074743562923248,0.21984448670613554,0.6578844212115511,2773]
["High","O14548","Cytochrome c oxidase subunit 7A-related protein, mitochondrial [OS=Homo sapiens]",11,1,1,1,114,12.6,9.42,3.4,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity","COX7A2L","ENSG00000115944","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",113.7,98.9,108.6,107.9,95.5,109.9,1.025215448451963,0.03592712314626089,0.6953955239209202,0.1577681090837371,0.8261789791196812,0.08292585918812583,6572]
["High","O14561","Acyl carrier protein, mitochondrial [OS=Homo sapiens]",13,2,5,2,156,17.4,4.93,6.75,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","NDUFAB1","ENSG00000004779","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",261.5,303.2,263.7,298.8,264.3,225.9,1.0499366286438532,0.07030225331969124,0.6276159551911735,0.20230602435309608,0.7823156733928293,0.10661796874434769,6264]
["High","O14562","Ubiquitin domain-containing protein UBFD1 [OS=Homo sapiens]",33,7,35,7,309,33.4,5.77,62.32,"","","","UBFD1","ENSG00000103353","","","",1480,1439.4,1337.5,1501.6,1249,1250.2,1.0640121975604877,0.08951468961650892,0.4155646618703073,0.3813613903911868,0.6134862695941311,0.2121951527515359,5289]
["High","O14578-4","Isoform 4 of Citron Rho-interacting kinase [OS=Homo sapiens]",19,36,55,36,2069,236.5,6.67,103.88,"","","","CIT","","","","",2465.2,2313,2521.7,2334.2,2420.4,2341.1,1.0287779923051987,0.04093168586971864,0.37463085289697234,0.42639645896521217,0.5762643221866746,0.23937826772924392,5076]
["High","O14579-1","coatomer subunit epsilon [OS=Homo sapiens]",34,12,29,12,308,34.5,5.12,61.56,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","COPE","ENSG00000105669; ENSPTRG00000010723","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",981.6,1053,1042.4,1006.3,1058.7,1036.1,0.9922285640579149,-0.011255605071067912,0.7803042943443295,0.10773600297179829,0.8787849315217835,0.056117398511934605,6933]
["High","O14617-5","Isoform 5 of AP-3 complex subunit delta-1 [OS=Homo sapiens]",39,34,102,4,1215,136.6,7.64,215.34,"","","","AP3D1","","","","",3659.9,3576.5,3642,3435.4,3664.9,3599.9,1.0166538943197323,0.023828617314370963,0.460609551946201,0.33666706004414393,0.6515288734775249,0.18606633311470747,5520]
["High","O14618","copper chaperone for superoxide dismutase [OS=Homo sapiens]",37,9,26,9,274,29,5.58,58.72,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CCS","ENSG00000173992","Amyotrophic lateral sclerosis (ALS); Copper homeostasis","Detoxification of Reactive Oxygen Species","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",1364.1,1354.4,1330.6,1418.4,1392,1396.4,0.9625130740705525,-0.05512195754971115,0.015057429186912294,1.8222491705817918,0.08153148896769154,1.0886746263065668,1442]
["High","O14628-1","Zinc finger protein 195 [OS=Homo sapiens]",17,8,12,3,629,72.3,8.09,18.84,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF195","ENSG00000005801","","Generic Transcription Pathway","Herpes simplex virus 1 infection",231.1,210.7,227.4,200.6,216.7,219,1.0517051705170515,0.07273032378664115,0.26827106242748905,0.5714261708086487,0.46787144414425613,0.3298734605334583,4477]
["High","O14639-1","Actin-binding LIM protein 1 [OS=Homo sapiens]",8,5,5,5,778,87.6,8.59,7.43,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ABLIM1","ENSG00000099204","Male infertility","DCC mediated attractive signaling","Axon guidance",193.5,130.8,156.9,213.4,149.2,144,0.9498618239242006,-0.07421043453642444,0.7833059735612758,0.10606856147627827,0.8806411866906323,0.05520100689127729,6945]
["High","O14641","Segment polarity protein dishevelled homolog DVL-2 [OS=Homo sapiens]",18,12,21,10,736,78.9,6.02,43.31,"cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","DVL2","ENSG00000004975","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)","RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; Degradation of DVL; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",1162.6,1163.9,1256.3,1051.7,1136.3,1099.4,1.089858246638681,0.12414050181824776,0.06737227446891303,1.1715187907410687,0.2013175350376092,0.6961183958097591,2613]
["High","O14646","Chromodomain-helicase-DNA-binding protein 1 [OS=Homo sapiens]",21,35,65,30,1710,196.6,7.14,121.56,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD1","ENSG00000153922","","Estrogen-dependent gene expression","",2517.8,2285.6,2687.9,2951.3,2811.6,3032.3,0.8517486810987811,-0.23150028652373428,0.031010728245146058,1.508488034822501,0.12519739717585338,0.9024046999108484,1934]
["High","O14647","Chromodomain-helicase-DNA-binding protein 2 [OS=Homo sapiens]",13,23,44,18,1828,211.2,8.1,79.25,"cell organization and biogenesis;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CHD2","ENSG00000173575","Prion disease pathway; Male infertility","","",1424.9,1275.8,1386.2,1670.5,1573.7,1733.9,0.8209758743295634,-0.2845882681297223,0.010007929449507205,1.9996557648451834,0.06544548839342734,1.1841202869798981,1194]
["High","O14653-1","Golgi SNAP receptor complex member 2 [OS=Homo sapiens]",24,4,4,4,212,24.8,8.06,11.17,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","GOSR2","ENSG00000108433","","COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER","SNARE interactions in vesicular transport",230.2,232.4,243.9,224.8,270.8,251.3,0.9459097603427499,-0.08022553766072757,0.3902822051986071,0.40862124979543835,0.5897664908439567,0.22931990668246466,5167]
["High","O14656","Torsin-1A [OS=Homo sapiens]",19,5,10,5,332,37.8,6.99,14.35,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TOR1A","ENSG00000136827","","Cargo recognition for clathrin-mediated endocytosis","",299.1,314.2,290.5,299.3,303.9,308.5,0.9913348689261817,-0.012555618572447266,0.7405393300696772,0.13045187113515103,0.8564851265270389,0.0672801744653359,6751]
["Low","O14657","Torsin-1B [OS=Homo sapiens]",2,1,2,1,336,38,8.54,4.48,"cell organization and biogenesis;stress response;other biological processes","other membranes;ER/Golgi;nucleus","cytoskeletal activity;other molecular function","TOR1B","ENSG00000136816","","Cargo recognition for clathrin-mediated endocytosis","",179.9,180.2,170.6,146.2,131.4,150.4,1.2399532710280374,0.31028575212310533,6.461026647798399E-3,2.1896984677560027,0.05080331930111772,1.2941079115927487,993]
["High","O14662-2","Isoform A of Syntaxin-16 [OS=Homo sapiens]",27,6,11,6,304,34.8,6.2,24.64,"","","","STX16","","","","",606.6,559.8,600.7,508,468.4,478.1,1.2149192162255074,0.28086038771951344,0.005318274643970002,2.2742292387831657,0.045482024556536445,1.3421602116588294,913]
["Medium","O14668-1","Transmembrane gamma-carboxyglutamic acid protein 1 [OS=Homo sapiens]",3,1,2,1,218,24.9,5.19,4.45,"","non-structural extracellular;plasma membrane;other membranes","other molecular function","PRRG1","ENSG00000130962; ENSNLEG00000000909","","","",93.8,108.1,109.4,84.7,84.7,83.4,1.2314082278481011,0.3003091132920765,0.017729517598893012,1.7513030809241241,0.08954209146970027,1.0479727658477949,1546]
["High","O14672","Disintegrin and metalloproteinase domain-containing protein 10 [OS=Homo sapiens]",28,17,39,17,748,84.1,7.77,86.88,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM10","ENSG00000137845","Alzheimer's disease and miRNA effects; Copper homeostasis; Canonical and non-canonical Notch signaling; VEGFA-VEGFR2 signaling pathway; 3q29 copy number variation syndrome; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Hypertrophy model","Amyloid fiber formation; Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus","Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection",1258.1,1276.1,1185.3,1402.5,1461.3,1422.4,0.8677849843684381,-0.20459047204753839,4.454317053909221E-3,2.35121887354746,0.04120771037550142,1.3850215155144796,844]
["High","O14681","Etoposide-induced protein 2.4 homolog [OS=Homo sapiens]",8,3,3,3,340,38.9,9.72,7.6,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EI24","ENSG00000149547","miRNA regulation of p53 pathway in prostate cancer","","p53 signaling pathway",281.8,272.9,254.5,250.2,254.4,259.3,1.0593009556224637,0.08311252842396037,0.14874495176155328,0.827557764821628,0.3279866092499881,0.48414388692110366,3541]
["High","O14682","Ectoderm-neural cortex protein 1 [OS=Homo sapiens]",3,2,4,2,589,66.1,6.84,7.6,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity","ENC1","ENSG00000171617","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","",311.3,354.3,298.2,226.9,189.6,188,1.594375516956162,0.6729914616035032,0.004819549961907989,2.316993513251816,0.043154869383689884,1.3649701935257474,872]
["High","O14683","Tumor protein p53-inducible protein 11 [OS=Homo sapiens]",18,3,12,3,189,21,9.55,34.84,"other biological processes","other membranes","","TP53I11","ENSG00000175274","","","",369.2,412.5,388.8,363.4,387.5,368.9,1.0452759421325237,0.06388384928638265,0.3081960994040485,0.5111728621069496,0.5086440803523168,0.29358600549687947,4731]
["High","O14686-1","Histone-lysine N-methyltransferase 2D [OS=Homo sapiens]",5,20,31,20,5537,593,5.58,54.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KMT2D","ENSG00000167548","Histone modifications; 16p11.2 proximal deletion syndrome","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Lysine degradation; Metabolic pathways; Cushing syndrome",923,806.9,924.5,1043.9,1007.9,1040.7,0.8583346806790624,-0.22038780379523099,0.02284957541810033,1.6411218654098552,0.10421114770124262,0.9820858210923542,1712]
["High","O14717-1","tRNA (cytosine(38)-C(5))-methyltransferase [OS=Homo sapiens]",7,2,2,2,391,44.6,6.09,4.6,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT2; TRDMT1","ENSG00000107614","","tRNA modification in the nucleus and cytosol","",12.7,19.4,13,14.5,12.1,16.5,1.0464037122969836,0.06543956416628259,0.8050507435309474,0.09417674455022355,0.8936360826684159,0.04883930387251194,7034]
["High","O14727","apoptotic protease-activating factor 1 [OS=Homo sapiens]",4,5,6,5,1248,141.7,6.4,12.17,"stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;other cell component","enzyme regulator activity;other molecular function","APAF1","ENSG00000120868","miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkinson's disease pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; p53 transcriptional gene network; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response","Neutrophil degranulation; Transcriptional Regulation by E2F6; Formation of apoptosome; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of the apoptosome activity","Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Legionellosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Small cell lung cancer; Lipid and atherosclerosis",258.9,254.3,246.2,274.7,288.6,287.1,0.8929915333960491,-0.16328159791201527,0.006229732619060759,2.2055305929168223,0.049837860952486074,1.3024406059248788,976]
["High","O14730","serine/threonine-protein kinase RIO3 [OS=Homo sapiens]",8,4,5,4,519,59.1,5.76,6.55,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;other cell component","kinase activity;other molecular function","RIOK3","ENSG00000101782","","Major pathway of rRNA processing in the nucleolus and cytosol","",134.1,131.4,138,156.3,170.7,169.8,0.8121980676328503,-0.30009650005533867,3.491936679596205E-3,2.456933640095703,0.03601722799773734,1.4434897149371404,757]
["High","O14732-1","inositol monophosphatase 2 [OS=Homo sapiens]",17,4,6,4,288,31.3,6.61,13.79,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA2","ENSG00000141401","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",461.8,457.8,427.1,423.4,430.8,440.3,1.0403244495944381,0.05703353684922772,0.2207504355741927,0.6560984308204653,0.41532997613573414,0.38160672287392255,4150]
["High","O14733","dual specificity mitogen-activated protein kinase kinase 7 [OS=Homo sapiens]",15,5,15,5,419,47.5,9.16,22,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAP2K7","ENSG00000076984","MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; MAPK signaling pathway; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; Alzheimer's disease; ErbB signaling pathway; Toll-like receptor signaling pathway","FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Uptake and function of anthrax toxins","MAPK signaling pathway; ErbB signaling pathway; Protein processing in endoplasmic reticulum; Osteoclast differentiation; Tight junction; Toll-like receptor signaling pathway; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Relaxin signaling pathway; Alcoholic liver disease; Alzheimer disease; Huntington disease; Pathways of neurodegeneration; Salmonella infection; Yersinia infection; Hepatitis B; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Chemical carcinogenesis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",721.2,698.3,899.3,719.2,743.3,785.6,1.031448778968907,0.044672179767939274,0.7406699028217916,0.13037530257938207,0.85650927150956,0.06726793153834526,6752]
["High","O14734","Acyl-coenzyme A thioesterase 8 [OS=Homo sapiens]",22,4,5,4,319,35.9,7.56,17.22,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOT8","ENSG00000101473","","Peroxisomal protein import; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids","Primary bile acid biosynthesis; Metabolic pathways; Peroxisome",74.3,88.8,85.9,69.5,96.1,78.4,1.0204918032786885,0.029264594505194617,0.8618739557767296,0.06455624265925287,0.9261645811594694,0.033311831527313374,7266]
["High","O14735","CDP-diacylglycerol--inositol 3-phosphatidyltransferase [OS=Homo sapiens]",19,4,6,4,213,23.5,8.03,11.57,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","CDIPT","ENSG00000103502","Glycerolipids and glycerophospholipids; 16p11.2 proximal deletion syndrome","Synthesis of PI","Inositol phosphate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system",490.2,490.5,508.5,483.9,454.7,449.6,1.0727560870191617,0.10132208723166683,0.051814143432691556,1.2855516770044662,0.17303885026623425,0.7618563791716519,2338]
["High","O14744","Protein arginine N-methyltransferase 5 [OS=Homo sapiens]",39,22,81,22,637,72.6,6.29,162.25,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","PRMT5","ENSG00000100462","Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis","RMTs methylate histone arginines; snRNP Assembly; Regulation of TP53 Activity through Methylation","",3417.4,3566,3467.6,3411.4,3594.4,3567.6,{"$f":"AVERAGE(T194:V194)/AVERAGE(W194:Y194)","v":0.9884237804301359},{"$f":"LOG(Z194,2)","v":-0.016798374087198812},{"$f":"TTEST(T194:V194,W194:Y194,2,2)","v":0.6004307653512511},{"$f":"-LOG10(AB194)","v":0.22153706313101604},{"$f":"AB194*7808/AF194","v":0.7599551654826663},{"$f":"-LOG10(AD194)","v":0.11921202871635996},6169]
["High","O14745","Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [OS=Homo sapiens]",44,13,23,13,358,38.8,5.77,51.87,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function","SLC9A3R1","ENSG00000109062","","","Tight junction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human papillomavirus infection",1110.7,988.2,887.5,1068.7,764.2,723.6,1.1681595931938198,0.22423738772876428,0.3208789618078603,0.49365875616804145,0.5221806864934917,0.2821791951412179,4798]
["High","O14757","Serine/threonine-protein kinase Chk1 [OS=Homo sapiens]",22,9,14,9,476,54.4,8.25,28.33,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CHEK1","ENSG00000149554","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; DNA damage response","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis",635.4,656,610.3,791,950.8,885.6,0.7237953870746745,-0.4663461817965544,0.007411304317331158,2.1301053536979837,0.054902717371652456,1.2604061599158758,1054]
["High","O14763","Tumor necrosis factor receptor superfamily member 10B [OS=Homo sapiens]",11,3,7,3,440,47.8,5.55,2.63,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TNFRSF10B","ENSG00000120889","miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer; miRNA regulation of p53 pathway in prostate cancer; Unfolded protein response; DNA damage response","Cell surface interactions at the vascular wall; Regulation by c-FLIP; RIPK1-mediated regulated necrosis; CASP8 activity is inhibited; TP53 Regulates Transcription of Death Receptors and Ligands; Dimerization of procaspase-8; TRAIL  signaling","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; p53 signaling pathway; Apoptosis; Necroptosis; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Salmonella infection; Influenza A; Lipid and atherosclerosis",50.5,38.1,48.3,45.2,53.9,50.2,0.916945746818486,-0.12509171887664222,0.4175231010164642,0.3793194905601995,0.6148661585697006,0.2112194092986387,5302]
["High","O14772","fucose-1-phosphate guanylyltransferase [OS=Homo sapiens]",7,4,5,3,594,66.6,6.48,10.02,"","","other molecular function","FPGT","ENSG00000254685","","","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",127.7,113.3,127.8,127.6,134.8,121.8,0.9599167100468506,-0.05901886323618907,0.4481456750909657,0.3485807904563706,0.6415697526788157,0.19275611940334622,5454]
["High","O14773","Tripeptidyl-peptidase 1 [OS=Homo sapiens]",20,7,15,7,563,61.2,6.48,42.56,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TPP1","ENSG00000166340","VEGFA-VEGFR2 signaling pathway","XBP1(S) activates chaperone genes","Lysosome",1058.2,1108.1,1076.3,1006.9,1079.6,1056.7,1.0316238228556887,0.04491699417513014,0.27070842521793415,0.5674982275367807,0.47033631154909433,0.32759149096125534,4494]
["High","O14775","Guanine nucleotide-binding protein subunit beta-5 [OS=Homo sapiens]",8,2,2,2,395,43.5,6.46,6.36,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","GNB5","ENSG00000069966","Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells","G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits","Ras signaling pathway; Chemokine signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Relaxin signaling pathway; Morphine addiction; Alcoholism; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",37.2,30.6,33.8,34.8,42,35.7,0.9031111111111111,-0.14702459933223358,0.28692954353304595,0.5422247325737721,0.48777397690094115,0.3117813733330602,4593]
["High","O14776-1","Transcription elongation regulator 1 [OS=Homo sapiens]",26,34,100,34,1098,123.8,8.65,216.66,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","TCERG1","ENSG00000113649; ENSGGOG00000003329; ENSPTRG00000017375","","","Spliceosome",6651.7,5914.5,6637,8191.5,7588,7916,0.8104154797324387,-0.3032663635914313,0.00748158928609415,2.126006136779198,0.05516170835299634,1.2583622922280477,1059]
["High","O14777","Kinetochore protein NDC80 homolog [OS=Homo sapiens]",36,20,40,20,642,73.9,5.6,78.95,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NDC80","ENSG00000080986","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",2104.5,2099.1,2244.4,2582.1,2464.5,2445.5,0.860639874000614,-0.2165184120606831,0.005528032971927707,2.257429375278656,0.046064974861058205,1.336629161507799,937]
["High","O14782","Kinesin-like protein KIF3C [OS=Homo sapiens]",6,5,5,2,793,89.4,8.22,13.05,"transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3C","ENSG00000084731","","Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",64.4,50.4,51.5,64.6,71,64.1,0.8327491236855284,-0.2640461641567033,0.09054634638949516,1.0431290690925397,0.2408810468855803,0.6181973700175376,2935]
["High","O14787-2","Isoform 2 of Transportin-2 [OS=Homo sapiens]",34,24,72,12,887,100.3,4.98,136.86,"","","","TNPO2","","","","",1248,1201.1,1274,1127,1119.9,1157.6,1.09358202379204,0.12906143335358505,0.011905520397595015,1.9242516165661645,0.07194915113345347,1.1429743255665943,1292]
["High","O14795","Protein unc-13 homolog B [OS=Homo sapiens]",9,12,19,11,1591,180.6,5.99,27.15,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","UNC13B","ENSG00000198722","Synaptic vesicle pathway; 16p11.2 proximal deletion syndrome; Monoamine transport","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle","Synaptic vesicle cycle",609.4,550.9,564.8,613.9,585.2,597,0.9604699070207673,-0.05818768211267267,0.2918949881328321,0.5347733618291881,0.4927818523980872,0.3073452942456041,4625]
["Medium","O14798","Tumor necrosis factor receptor superfamily member 10C [OS=Homo sapiens]",4,1,1,1,259,27.4,4.82,2.91,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TNFRSF10C","ENSG00000173535","Apoptosis modulation and signaling; VEGFA-VEGFR2 signaling pathway","TP53 Regulates Transcription of Death Receptors and Ligands","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor",82.1,84.5,77.2,85.1,67.6,81.5,1.0409906063193852,0.05795705011899707,0.6076220087921247,0.21636650386148207,0.7659529616804827,0.11579790022361462,6194]
["High","O14802","DNA-directed RNA polymerase III subunit RPC1 [OS=Homo sapiens]",28,29,60,28,1390,155.5,8.48,110.91,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3A","ENSG00000148606","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",2090.4,2210,2093.5,2155.8,2243.5,2177,0.9722640390493134,-0.04057993321904072,0.268917847058717,0.5703803743407926,0.4682672947891308,0.3295061736050927,4484]
["High","O14818-1","Proteasome subunit alpha type-7 [OS=Homo sapiens]",66,16,112,16,248,27.9,8.46,245.84,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","HEL-S-276; PSMA7","ENSG00000101182","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",4730.2,4907.5,4921.9,4898.8,5158.8,4812.4,0.9791257565568258,-0.030433926877307414,0.4406207559336833,0.35593504877592214,0.6361625115255546,0.19643192705086626,5408]
["Low","O14827","Ras-specific guanine nucleotide-releasing factor 2 [OS=Homo sapiens]",1,1,1,1,1237,140.7,7.53,0,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","RASGRF2","ENSG00000113319","MAPK signaling pathway; Ras signaling","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor","MAPK signaling pathway; Ras signaling pathway",77.9,103.6,92.8,93.3,103.9,93.2,0.9445592286501379,-0.08228683114747322,0.5509758297586531,0.2588674523872012,0.7259566788315159,0.1390892948725981,5926]
["High","O14828","Secretory carrier-associated membrane protein 3 [OS=Homo sapiens]",41,9,31,9,347,38.3,7.64,88.4,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCAMP3","ENSG00000116521; ENSG00000263290","","","",669.8,659.3,737.3,671.9,644.6,688.5,1.0306234413965085,0.04351731188835488,0.4993455683267757,0.3015988001178156,0.6849771956246424,0.16432388687142688,5692]
["High","O14832","Phytanoyl-CoA dioxygenase, peroxisomal [OS=Homo sapiens]",10,4,8,4,338,38.5,8.47,16,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","PHYH","ENSG00000107537","","TYSND1 cleaves peroxisomal proteins; Alpha-oxidation of phytanate","Peroxisome",642.6,601,659.8,713.8,677.9,671.2,0.9226816617383296,-0.11609511142454967,0.07215241595810429,1.141749122370811,0.21013281007119666,0.6775061316950551,2681]
["High","O14841","5-oxoprolinase [OS=Homo sapiens]",10,9,11,9,1288,137.4,6.58,25.59,"other metabolic processes","cytosol","other molecular function","OPLAH","ENSG00000178814","Glutathione metabolism","Glutathione synthesis and recycling; Defective OPLAH causes OPLAHD","Glutathione metabolism; Metabolic pathways",142.5,160.3,157.9,134.7,151.1,147.1,1.0642180642180645,0.08979379739185708,0.28135345024277403,0.5507477547157452,0.4812284204809594,0.31764873192742754,4565]
["High","O14867","Transcription regulator protein BACH1 [OS=Homo sapiens]",29,17,28,17,736,81.9,5.05,55.25,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH1","ENSG00000156273","Integrated cancer pathway; Ferroptosis","Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity","",1156.9,1193.7,1220.7,1001.9,905.7,922.1,1.2620772520055132,0.33580022068037585,2.1189867467084197E-3,2.673871759593783,0.029597582322539073,1.5287437628215712,559]
["Medium","O14874","[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial [OS=Homo sapiens]",4,1,1,1,412,46.3,8.82,2.17,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","BCKDK","ENSG00000103507","Thiamine metabolic pathways","Branched-chain amino acid catabolism","",21.8,15.2,12.3,12.9,15.3,16.6,1.1004464285714284,0.13808891432030718,0.6446750333628903,0.1906591485924994,0.792696481968102,0.10089306922583965,6350]
["High","O14880","Microsomal glutathione S-transferase 3 [OS=Homo sapiens]",28,3,20,3,152,16.5,9.38,43.62,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","MGST3","ENSG00000143198","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II","Aflatoxin activation and detoxification; Glutathione conjugation","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",495,548.9,502,440.3,514.9,481.5,1.0760075172269785,0.10568815691702783,0.25501815271161166,0.5934289044998028,0.4534688536488872,0.3434525369455552,4391]
["High","O14893","Gem-associated protein 2 [OS=Homo sapiens]",29,7,13,7,280,31.6,5.58,27.35,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","GEMIN2","ENSG00000092208","","snRNP Assembly","",380.7,390.7,397.5,444.1,422.3,454.6,0.8848599545798639,-0.1764789547434673,0.00902112838012921,2.0447391366693473,0.06151700470921298,1.2110048186866187,1145]
["Medium","O14896-1","Interferon regulatory factor 6 [OS=Homo sapiens]",3,1,1,1,467,53.1,5.33,0,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IRF6","ENSCANG00000037044; ENSCATG00000039683; ENSG00000117595; ENSGGOG00000006214; ENSMFAG00000033961; ENSMMUG00000022065; ENSMNEG00000040867; ENSNLEG00000001962; ENSPPAG00000032756; ENSPPYG00000000253; ENSPTRG00000001941","Apoptosis; Primary focal segmental glomerulosclerosis (FSGS); Hypothetical craniofacial development pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway","Interferon gamma signaling; Interferon alpha/beta signaling","",9.5,11.6,10.9,14,8.8,13.1,0.8913649025069638,-0.16591193893568904,0.4916334729016004,0.3083585558068051,0.6789306962178451,0.16817455530167047,5654]
["High","O14907","Tax1-binding protein 3 [OS=Homo sapiens]",26,3,6,3,124,13.7,8.48,13.43,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TAX1BP3","ENSG00000213977","","RHO GTPases Activate Rhotekin and Rhophilins","",342.9,304.3,285.7,190.8,192.8,205.6,1.5833333333333335,0.6629650127224295,2.7973503482365855E-3,2.5532531379268733,0.032406100176604245,1.4893732298035578,674]
["High","O14908-1","PDZ domain-containing protein GIPC1 [OS=Homo sapiens]",32,8,18,8,333,36,6.28,43.29,"cell-cell signaling;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GIPC1","ENSG00000123159","VEGFA-VEGFR2 signaling pathway","","",1280.3,1254.6,1315.8,1317.1,1243,1299,0.9978233266823872,-3.1436984457833793E-3,0.9264638352452745,0.03317152881131087,0.961945428935519,0.01684956474431774,7520]
["High","O14910","Protein lin-7 homolog A [OS=Homo sapiens]",15,4,11,2,233,26,8.72,19.9,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","LIN7A","ENSG00000111052","","Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle","",451.8,455.4,421.4,500.7,440.3,421.6,0.9750477029208865,-0.036455292349330586,0.6875326508056979,0.16270667243874037,0.8220911083446998,0.08508004905517887,6530]
["High","O14920-1","Inhibitor of nuclear factor kappa-B kinase subunit beta [OS=Homo sapiens]",15,6,9,6,756,86.5,5.78,13.02,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","IKBKB","ENSG00000104365","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",132.3,155.8,156.6,170.1,187.2,181.4,0.8255058474104328,-0.276649660487587,0.029203626320128444,1.5345632172831776,0.12115935935577199,0.9166430317157803,1882]
["High","O14924","Regulator of G-protein signaling 12 [OS=Homo sapiens]",4,5,5,4,1447,156.3,7.44,4.95,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","RGS12","ENSG00000159788","","G alpha (i) signalling events","",24,15.2,8.1,18.9,19.1,15,0.8924528301886793,-0.16415217611116628,0.7117807293856437,0.1476537741781532,0.8385008954500763,0.07649646926681697,6628]
["High","O14929","histone acetyltransferase type B catalytic subunit [OS=Homo sapiens]",35,10,88,10,419,49.5,5.69,190.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","HAT1","ENSG00000128708","Ethanol effects on histone modifications","HATs acetylate histones","Neutrophil extracellular trap formation; Alcoholism",3037.8,3164.7,3031.8,2873.4,3083.5,2958.7,1.0357463322715241,0.050670711533096574,0.22872835513752315,0.6406799931701476,0.4242068876279764,0.3724222843471805,4210]
["Medium","O14933","Ubiquitin/ISG15-conjugating enzyme E2 L6 [OS=Homo sapiens]",5,1,2,1,153,17.8,7.88,4.52,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UBE2L6","ENSG00000156587","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome","Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration",103.9,105.1,101.3,140.9,104.2,100.4,0.8981186685962373,-0.1550220137469018,0.41654566736246307,0.3803373784197487,0.614237690418529,0.21166353820461717,5295]
["High","O14936","peripheral plasma membrane protein CASK [OS=Homo sapiens]",29,23,54,23,926,105.1,6.43,119,"cell adhesion;protein metabolism;other metabolic processes;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CASK","ENSG00000147044","Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions","",3240.7,3357.6,3285.3,3035,3239,3119,1.0522303843287553,0.07345061521909112,0.07479832145594044,1.126108147999204,0.21416402417601135,0.6692534812821984,2727]
["High","O14939-1","Phospholipase D2 [OS=Homo sapiens]",5,5,6,5,933,105.9,7.64,8.76,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","PLD2","ENSG00000129219","Ras signaling; EGF/EGFR signaling pathway","Role of phospholipids in phagocytosis; RAC1 GTPase cycle; RAC2 GTPase cycle; Synthesis of PG; Synthesis of PA","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways; Ras signaling pathway; cAMP signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Endocytosis; Fc gamma R-mediated phagocytosis; Glutamatergic synapse; GnRH signaling pathway; Parathyroid hormone synthesis, secretion and action; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Choline metabolism in cancer",349.5,351.8,359.9,312.2,324.9,313.7,1.1161127471602859,0.15848277228626084,1.9549607663412855E-3,2.7088619539368914,0.028855073088077044,1.5397778213134417,529]
["High","O14949","Cytochrome b-c1 complex subunit 8 [OS=Homo sapiens]",29,3,6,3,82,9.9,10.08,11.63,"other metabolic processes;transport;developmental processes","other membranes;mitochondrion","","UQCRQ","ENSG00000164405","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly","Respiratory electron transport","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",545.5,568.9,444,497.1,553.4,533.5,0.9838383838383838,-0.023506752884629795,0.8479437426399501,0.07163296032760816,0.9192925218734699,0.036546272704239297,7202]
["High","O14950","Myosin regulatory light chain 12B [OS=Homo sapiens]",40,6,23,6,172,19.8,4.84,56.04,"other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL12B","ENSG00000118680","Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion","RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Salmonella infection",624.4,615.1,610.4,599.7,449.7,473.8,1.214482668067227,0.2803419013596311,0.08003311077226388,1.0967303023741564,0.2236573117071712,0.650416899493684,2794]
["High","O14964","Hepatocyte growth factor-regulated tyrosine kinase substrate [OS=Homo sapiens]",24,16,34,16,777,86.1,6.16,73.13,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","HGS","ENSG00000185359","TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway","Lysosome Vesicle Biogenesis; Ub-specific processing proteases; Cargo recognition for clathrin-mediated endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle","Endocytosis; Phagosome",1671.2,1602.8,1734.3,1599.1,1499.7,1559.4,1.0751577862693744,0.10454840006022746,0.07074856406315495,1.150282370302283,0.2077490741651425,0.6824609029752147,2659]
["High","O14965","Aurora kinase A [OS=Homo sapiens]",16,5,11,5,403,45.8,9.39,24.71,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AURKA","ENSG00000087586","Gastric cancer network 1; EGF/EGFR signaling pathway","Regulation of TP53 Activity through Phosphorylation; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA","Oocyte meiosis; Progesterone-mediated oocyte maturation",261.1,268.2,263.9,250.8,257.3,258.9,1.0341590612777054,0.04845809983855218,0.0536270151696761,1.270616374795532,0.1757849430918686,0.7550183272836553,2382]
["High","O14966-1","Ras-related protein Rab-7L1 [OS=Homo sapiens]",23,4,5,4,203,23.1,7.18,10.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB29; RAB7L1","ENSG00000117280; ENSNLEG00000029152; ENSPPAG00000013675; ENSPPYG00000000298; ENSPTRG00000001905","","RAB geranylgeranylation","",399.1,423.3,428.7,455.2,493.6,480.5,0.8753235849716645,-0.1921116515025613,0.014846996458283997,1.8283613950690938,0.08095345554907922,1.0917646083822952,1432]
["High","O14967","calmegin [OS=Homo sapiens]",28,13,34,12,610,70,4.69,44.08,"cell organization and biogenesis;stress response;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","CLGN","ENSG00000153132","","","",1193.1,1174.1,1202.2,1226.7,1270.6,1217.4,0.9608851320429644,-0.05756411897361367,0.057830013074847135,1.2378467095063082,0.18385046501970945,0.7355352673168029,2456]
["High","O14972","Down syndrome critical region protein 3 [OS=Homo sapiens]",8,2,3,2,297,33,7.68,5.94,"transport","other cytoplasmic organelle","","VPS26C","ENSG00000157538","","","",79.2,73.5,74.8,76.3,77.2,79.5,0.9763948497854076,-0.03446340956822184,0.40479971170346696,0.3927598054707228,0.602607464057325,0.21996549334166413,5245]
["High","O14974","Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",49,45,141,44,1030,115.2,5.4,267.69,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12A","ENSG00000058272","Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton","Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","cGMP-PKG signaling pathway; cAMP signaling pathway; Vascular smooth muscle contraction; Focal adhesion; Platelet activation; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer",7156.1,6751.3,7268.3,6996.8,6526,6694.9,1.047384222735524,0.06679077803752473,0.20097871626901379,0.6968499321135644,0.39250670751087036,0.40615291723702707,3998]
["Medium","O14975","very long-chain acyl-CoA synthetase [OS=Homo sapiens]",2,1,1,1,620,70.3,8.51,0,"other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC27A2","ENSG00000140284","PPAR signaling pathway","Peroxisomal protein import; Neutrophil degranulation; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Alpha-oxidation of phytanate; Synthesis of bile acids and bile salts via 24-hydroxycholesterol","PPAR signaling pathway; Peroxisome; Insulin resistance",18.7,19.5,15.3,19.3,27.1,21,0.7937685459940652,-0.3332096998933493,0.16075053310256704,0.7938475781355023,0.34453476872490896,0.46276694471878294,3643]
["High","O14976","Cyclin-G-associated kinase [OS=Homo sapiens]",20,15,36,15,1311,143.1,5.73,66.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","GAK","ENSG00000178950","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","",1027,983.4,1003.3,1031.2,1100.1,1056.3,0.9454448487890573,-0.08093479186745824,0.07116558032262724,1.1477300048221708,0.20858140058523778,0.680724420661799,2664]
["High","O14979-1","Heterogeneous nuclear ribonucleoprotein D-like [OS=Homo sapiens]",29,14,153,12,420,46.4,9.57,280.03,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPDL; HNRPDL","ENSG00000152795; ENSPPAG00000043177; ENSPTRG00000016217","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",4401.5,4570.3,4349.2,5138.9,5004.2,5184.7,0.8690744920993227,-0.2024482529727547,1.469005296720696E-3,2.832976638292505,0.02571747389415963,1.5897716923460115,446]
["High","O14980","Exportin-1 [OS=Homo sapiens]",44,39,187,39,1071,123.3,6.06,400.66,"transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPO1","ENSG00000082898","eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MAPK6/MAPK4 signaling; Deactivation of the beta-catenin transactivating complex; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Heme signaling; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Influenza A; Human T-cell leukemia virus 1 infection",8146.2,8195.1,7867.4,8362.6,9213.2,8926.3,0.9134634613860786,-0.13058107280129252,0.04722286524679563,1.3258476656452403,0.16257325037344808,0.7889509112074737,2268]
["High","O14981","TATA-binding protein-associated factor 172 [OS=Homo sapiens]",10,13,29,13,1849,206.8,6.52,67.1,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BTAF1","ENSG00000095564","","","",883.2,855.2,890.8,869.1,845.2,868.7,1.0178861788617886,0.02557624670601603,0.31453900930596657,0.5023254854310115,0.5156247290911163,0.2876662622839666,4763]
["High","O14994","Synapsin-3 [OS=Homo sapiens]",5,2,2,2,580,63.3,9.39,2.45,"cell-cell signaling;transport;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","SYN3","ENSG00000185666","Synaptic vesicle pathway","Serotonin Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle","",85.4,79.7,86.1,132.8,147.2,123.7,0.6222442407728511,-0.6844471225888831,0.002051879428545323,2.687848162593306,0.029235537551244306,1.5340889164190399,548]
["High","O15013","rho guanine nucleotide exchange factor 10 [OS=Homo sapiens]",12,11,18,11,1369,151.5,5.68,26.01,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity","ARHGEF10","ENSG00000104728; ENSG00000274726","","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events","",694.1,683.7,655.8,626.4,654.6,680.4,1.0368104415213621,0.052152152516536494,0.28121729042021476,0.550957980582378,0.48110092103440777,0.3177638116699196,4564]
["High","O15014","zinc finger protein 609 [OS=Homo sapiens]",10,15,23,14,1411,151.1,8.03,37.1,"developmental processes;other biological processes","nucleus","other molecular function","ZNF609","ENSG00000180357","","","",1117.3,940,1168.4,1305.5,1080.6,1149.2,0.9124261024524085,-0.1322203753964679,0.3429485438363032,0.4647710368212426,0.5454761112800683,0.2632242642624766,4909]
["High","O15015","Zinc finger protein 646 [OS=Homo sapiens]",6,10,10,9,1829,200.6,7.33,23.91,"","","","","","","","",476.6,476,482,517.1,493.9,510.6,0.9428233438485805,-0.08494061542777927,0.015531542001141567,1.8087854245456148,0.08300498285072783,1.0808958358212761,1461]
["High","O15020","Spectrin beta chain, non-erythrocytic 2 [OS=Homo sapiens]",26,51,98,39,2390,271.2,6.11,197.61,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTBN2","ENSG00000173898","","MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","Spinocerebellar ataxia; Pathways of neurodegeneration",1891.3,1968.4,1906.3,1769.7,1840,1770.8,1.0716476163925286,0.0998305908162259,0.017863097389951815,1.7480432339842438,0.08992589582252983,1.0461152271392133,1551]
["High","O15027-5","Isoform 5 of Protein transport protein Sec16A [OS=Homo sapiens]",16,27,61,27,2201,235.6,5.67,122.53,"","","","","","","","",2441.3,2270.6,2486,2402.1,2268.4,2306.2,1.0317055341350494,0.045031260428533317,0.39111894508323514,0.4076911471114424,0.5904595365835074,0.22880985866116338,5172]
["High","O15031","Plexin-B2 [OS=Homo sapiens]",15,19,27,19,1838,205,6.24,58.63,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PLXNB2","ENSG00000196576","","","Axon guidance",866.1,855.2,894,884.6,871.9,852.3,1.0024915670039867,0.003590100727378089,0.8913529547196081,0.04995029154763018,0.9426633984086008,0.02564335531145974,7383]
["High","O15037","protein KHNYN [OS=Homo sapiens]",8,3,4,3,678,74.5,7.02,11.83,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHNYN","ENSG00000100441","","","",161.5,160.5,164.1,161.1,161.8,161.5,1.0035094962840627,0.005054269094252778,0.6311668808072377,0.19985579791654975,0.7851124749630256,0.1050681219086251,6277]
["Medium","O15040","Tectonin beta-propeller repeat-containing protein 2 [OS=Homo sapiens]",1,1,1,1,1411,153.8,5.55,2.2,"other metabolic processes;transport","other cell component","","TECPR2","ENSG00000196663","","","",19.5,21.1,13.9,23.7,18.5,17.7,0.9098497495826378,-0.13629977312449693,0.5660309672140513,0.24715980817164845,0.7354917277429377,0.13342220752625172,6009]
["High","O15042","U2 snRNP-associated SURP motif-containing protein [OS=Homo sapiens]",34,28,87,28,1029,118.2,8.47,154.17,"RNA metabolism OR transcription;other metabolic processes","nucleus","","U2SURP","ENSG00000163714","","mRNA Splicing - Major Pathway","Spliceosome",3852.7,3577.9,3981.6,4470.7,4276.8,4403.2,0.8678017139772028,-0.20456265929277984,0.011755671078886615,1.9297525738943333,0.07159772214036403,1.1451007944184965,1282]
["High","O15047","Histone-lysine N-methyltransferase SETD1A [OS=Homo sapiens]",11,13,20,12,1707,185.9,5.14,42.36,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETD1A","ENSG00000099381","Histone modifications","PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Lysine degradation; Metabolic pathways",581.1,593.4,620.5,645.2,598,633.4,0.9565171054033892,-0.06413732635781128,0.2123161849021544,0.6730168982231793,0.40621533244695457,0.3912436883378148,4081]
["Low","O15050","TPR and ankyrin repeat-containing protein 1 [OS=Homo sapiens]",0,1,1,1,2925,336,6.76,0,"","","","TRANK1","ENSG00000168016","","","",44.2,46.4,55.6,55.3,47.1,43.3,1.0034317089910776,0.00494243388792481,0.9748692125981873,0.011053644872611165,0.987132513547743,0.005624543338859453,7711]
["High","O15054","Lysine-specific demethylase 6B [OS=Homo sapiens]",2,2,2,2,1643,176.5,8.54,2.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6B","ENSG00000132510","Pathways affected in adenoid cystic carcinoma; Vitamin D-sensitive calcium signaling in depression","Oxidative Stress Induced Senescence; HDMs demethylate histones","",51.3,49.9,55.1,58.3,61.6,53,0.9039907460960092,-0.14562009064261752,0.13369858633958198,0.873873184721296,0.30488275763418693,0.5158671360677762,3424]
["High","O15056","Synaptojanin-2 [OS=Homo sapiens]",3,5,5,5,1496,165.4,7.34,10.21,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ2","ENSG00000078269","","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",194.7,199.4,203.3,213.9,228,238.3,0.878271096736254,-0.18726176839705141,0.02117080720775211,1.6742625827368867,0.09886463078835435,1.0049590511812487,1672]
["High","O15061-1","Synemin [OS=Homo sapiens]",3,3,3,3,1565,172.7,5.16,2.25,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SYNM","ENSG00000182253","","","",16.8,27.7,22.2,24.1,26.1,20.7,0.9407616361071931,-0.08809886605493134,0.7110905086965733,0.14807511808060653,0.837814198265104,0.07685228401306855,6627]
["High","O15063","Uncharacterized protein KIAA0355 [OS=Homo sapiens]",4,3,3,3,1070,115.9,7.15,9.75,"signal transduction","cytosol;other cell component","other molecular function","GARRE1","ENSG00000166398","","RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",123.1,115.4,108.6,110.1,116.5,106,1.0435959110042092,0.06156319654137702,0.40396388579218806,0.3936574589048177,0.6019370267682069,0.22044894122990896,5240]
["High","O15066","Kinesin-like protein KIF3B [OS=Homo sapiens]",12,9,10,6,747,85.1,7.69,24.97,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3B","ENSG00000101350","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",550.5,451.9,532.2,577.9,605.5,615.9,0.8528872339243037,-0.22957308934930687,0.05250769935997884,1.2797770100343075,0.17394150046784676,0.759596787899996,2357]
["High","O15067","Phosphoribosylformylglycinamidine synthase [OS=Homo sapiens]",35,36,100,36,1338,144.6,5.76,222.91,"other metabolic processes;other biological processes","cytosol","other molecular function","PFAS","ENSG00000178921","","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Metabolic pathways",4392.5,4471.2,4499.7,4922.7,4720.6,4724.6,0.9300872082907037,-0.10456210009689935,0.010625848965572088,1.9736363613873946,0.06772786018219336,1.1692326454293103,1225]
["High","O15068","Guanine nucleotide exchange factor DBS [OS=Homo sapiens]",4,3,3,3,1137,128,6.43,6.81,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","MCF2L","ENSG00000126217","","CDC42 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RHOB GTPase cycle","",65.9,62.2,66.5,81,80.3,75.6,{"$f":"AVERAGE(T258:V258)/AVERAGE(W258:Y258)","v":0.8214436471084847},{"$f":"LOG(Z258,2)","v":-0.2837664884591195},{"$f":"TTEST(T258:V258,W258:Y258,2,2)","v":2.863463676007295E-3},{"$f":"-LOG10(AB258)","v":2.5431083216862027},{"$f":"AB258*7808/AF258","v":0.03283101965090302},{"$f":"-LOG10(AD258)","v":1.4837156289403526},681]
["High","O15069","NAC-alpha domain-containing protein 1 [OS=Homo sapiens]",1,1,2,1,1562,161,4.23,4.2,"transport","translational apparatus;nucleus;other cell component","other molecular function","NACAD","ENSG00000136274","","","",30.6,28.3,28.9,34.2,30.8,30.1,0.9232386961093587,-0.11522440132520503,0.16666086480098288,0.7781663689563002,0.35122484004482435,0.45441477661301183,3705]
["High","O15075-1","serine/threonine-protein kinase DCLK1 [OS=Homo sapiens]",11,4,8,4,740,82.2,8.66,21.01,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","DCLK1; LOC111158544","ENSCANG00000018654; ENSCCAG00000004898; ENSCJAG00000018203; ENSG00000133083; ENSMFAG00000030114; ENSMLEG00000042752; ENSMMUG00000016791; ENSMNEG00000028724; ENSNLEG00000001363; ENSPPAG00000038110; ENSPTRG00000005778; ENSRBIG00000027120; ENSRROG00000019788; ENSSBOG00000035278","Orexin receptor pathway","","",245.1,225.2,263.2,267.3,275.7,291.5,0.8789694427801078,-0.18611508368920893,0.0615574220374925,1.210719576272901,0.1914901797883432,0.7178534930953038,2510]
["High","O15078-1","Centrosomal protein of 290 kDa [OS=Homo sapiens]",3,6,7,6,2479,290.2,5.95,16.08,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CEP290","ENSG00000198707","Clear cell renal cell carcinoma pathways; Ciliary landscape; Joubert syndrome; Ciliopathies","Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",576.2,606.7,584.8,696.3,621.4,604,0.9198626216370923,-0.1205096792416655,0.15936778644853686,0.7975994594862535,0.34288886100583515,0.4648466230281746,3629]
["High","O15083","ERC protein 2 [OS=Homo sapiens]",6,7,14,1,957,110.5,6.99,27.61,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","ERC2","ENSG00000187672","Exercise-induced circadian regulation","","",36.4,116.2,66.6,66.6,48.7,79.4,1.125834617360041,0.17099491424023203,0.7594474630235363,0.11950226433991144,0.8671783842187439,0.06189155614185189,6838]
["High","O15084","serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A [OS=Homo sapiens]",12,9,11,9,1053,112.9,6.25,28.1,"","cytosol;nucleus","","ANKRD28","ENSG00000206560","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",322.1,329.6,345.7,318.3,346.7,327.2,1.0052408788550695,0.007541245772436016,0.8813542877174464,0.054849478340390966,0.9366563602147572,0.028419713526132137,7347]
["High","O15085-2","Isoform 2 of Rho guanine nucleotide exchange factor 11 [OS=Homo sapiens]",15,16,21,16,1562,172.1,5.54,39.81,"","","","ARHGEF11","","","","",522.7,465.3,534.5,554.2,551.1,549.1,0.9202732108317214,-0.11986586263387759,0.10942213284639407,0.9608948242469784,0.26994250024159394,0.568728733941717,3165]
["High","O15091","Mitochondrial ribonuclease P protein 3 [OS=Homo sapiens]",16,8,10,8,583,67.3,8.78,22.84,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","other molecular function","PRORP","ENSG00000100890","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",313.1,331.3,314.8,445.8,391.2,415,0.7661341853035144,-0.384330998405757,0.004403464563674838,2.3562054942367183,0.04093125156330135,1.3879449756399644,840]
["High","O15111","Inhibitor of nuclear factor kappa-B kinase subunit alpha [OS=Homo sapiens]",4,2,2,2,745,84.6,6.73,8.32,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CHUK","ENSG00000213341","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Constitutive Signaling by AKT1 E17K in Cancer; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; AKT phosphorylates targets in the cytosol","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",66.4,66.6,61.2,64.6,58,53.9,1.1002832861189802,0.13787501726064966,0.1749855123390222,0.7569979065804243,0.3624103130883516,0.4407994521275818,3770]
["High","O15116","U6 snRNA-associated Sm-like protein LSm1 [OS=Homo sapiens]",29,4,6,4,133,15.2,5.22,5.98,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM1","ENSG00000175324","","mRNA decay by 5' to 3' exoribonuclease","RNA degradation",341,382.3,342.9,369.8,338.9,323.4,1.0330394341633562,0.046895327180749916,0.5849805346762507,0.23285858489788808,0.74902066493148,0.12550620026861456,6098]
["High","O15118","Niemann-Pick C1 protein [OS=Homo sapiens]",5,7,10,7,1278,142.1,5.36,21.92,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","NPC1","ENSG00000141458","Irinotecan pathway; Irinotecan pathway; Irinotecan pathway; Ebola virus infection in host; Irinotecan pathway; Irinotecan pathway","LDL clearance","Lysosome; Cholesterol metabolism",517,539.5,498,456,446.7,449.4,1.1496930700391983,0.20124876079191137,0.005393453354927914,2.2681330728940403,0.0455265770759753,1.3417350009744378,925]
["High","O15120","1-acyl-sn-glycerol-3-phosphate acyltransferase beta [OS=Homo sapiens]",6,1,2,1,278,30.9,9.01,4.84,"other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","AGPAT2","ENSG00000169692","Adipogenesis; Triacylglyceride synthesis; Ciliary landscape; Congenital generalized lipodystrophy (CGL)","Neutrophil degranulation; Synthesis of PA","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fat digestion and absorption",17.2,16.6,17.8,18.7,16.6,18.2,0.9644859813084112,-0.052167825865255146,0.42983788809690227,0.36669530623359947,0.6255683560597601,0.20372522787693395,5365]
["High","O15121","Sphingolipid delta(4)-desaturase DES1 [OS=Homo sapiens]",6,3,5,3,323,37.8,7.46,14.01,"cell organization and biogenesis;other metabolic processes;developmental processes","plasma membrane;other membranes;mitochondrion;ER/Golgi","other molecular function","DEGS1","ENSG00000143753","Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence","Neutrophil degranulation; Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",114.8,115.4,121.9,118.4,103.4,121.9,1.0244399185336048,0.03483537549083395,0.6706756008120653,0.17348749301141317,0.8106246271115489,0.09118020634786186,6460]
["High","O15126-1","Secretory carrier-associated membrane protein 1 [OS=Homo sapiens]",6,2,5,2,338,37.9,7.42,13.7,"transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP1","ENSG00000085365","","Neutrophil degranulation","",283,302.6,308.4,318.7,286.6,308.3,0.9785464098073556,-0.03128781929216251,0.620256337863204,0.20742878935328846,0.7762400202012978,0.11000397032501633,6239]
["High","O15127","Secretory carrier-associated membrane protein 2 [OS=Homo sapiens]",17,4,13,4,329,36.6,6.1,33.7,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP2","ENSG00000140497","Serotonin transporter activity; Monoamine transport","","",588.2,566.2,597.2,602.3,551.6,594.7,1.0017156582408784,2.4730507870895126E-3,0.9589869264859479,0.018187313365012232,0.9800745971207173,0.008740867282066791,7640]
["High","O15143","Actin-related protein 2/3 complex subunit 1B [OS=Homo sapiens]",30,9,23,9,372,40.9,8.35,62.02,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ARPC1B","ENSG00000130429","Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",1641.6,1718.1,1571.2,1462.1,1745.6,1690.8,1.00661426967439,9.510954609044709E-3,0.9163911958521647,0.037919091908644134,0.9556808410863766,0.019687120378047686,7487]
["High","O15144","Actin-related protein 2/3 complex subunit 2 [OS=Homo sapiens]",59,17,56,17,300,34.3,7.36,116.07,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","ARPC2","ENSG00000163466","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",3075.7,3200.9,2975.9,2739,3446.9,3096,0.9968325450608172,-0.004576923965884186,0.9657445669659404,0.015137726406905102,0.983376836055042,0.007280025954294701,7668]
["High","O15145","Actin-related protein 2/3 complex subunit 3 [OS=Homo sapiens]",21,4,14,4,178,20.5,8.59,26.18,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC3","ENSG00000111229","Pathogenic Escherichia coli infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",564.6,607.8,486.5,472.6,494.8,488.7,1.1392761486161664,0.1881174836144252,0.13449835223286735,0.8712830362605081,0.30617000998082455,0.5140373516446431,3430]
["High","O15151","Protein Mdm4 [OS=Homo sapiens]",5,2,2,2,490,54.8,5,2.63,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","nucleus","other molecular function","MDM4","ENSG00000198625","Glioblastoma signaling pathways; Malignant pleural mesothelioma","Regulation of TP53 Activity through Methylation; Ub-specific processing proteases; Regulation of TP53 Degradation; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Oncogene Induced Senescence; Stabilization of p53","p53 signaling pathway; MicroRNAs in cancer",37.1,40.2,40.6,55.8,52,55.4,0.7224264705882354,-0.46907733899173276,7.6592365098858417E-4,3.115814519671485,0.01874712183987105,1.7270653980700306,319]
["High","O15155","BET1 homolog [OS=Homo sapiens]",25,2,3,2,118,13.3,9.06,9.82,"cell organization and biogenesis;transport","other membranes;ER/Golgi","other molecular function","BET1","ENSG00000105829","","COPI-mediated anterograde transport; COPII-mediated vesicle transport","SNARE interactions in vesicular transport",148.6,146.3,148.9,161,174.2,184,0.8547765793528502,-0.22638071580212768,0.02006212207557915,1.6976231312871382,0.09574880755875427,1.0188666259638068,1636]
["Medium","O15156","Zinc finger and BTB domain-containing protein 7B [OS=Homo sapiens]",1,1,1,1,539,58,5.86,2.12,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB7B","ENSG00000160685","Ectoderm differentiation; Ectoderm differentiation","","",55.3,53.8,55.8,91.2,72.1,89.8,0.6515211378901619,-0.6181161086732174,0.008902517646620011,2.050487156791917,0.06108159735044732,1.214089614192334,1138]
["High","O15160","DNA-directed RNA polymerases I and III subunit RPAC1 [OS=Homo sapiens]",34,9,31,9,346,39.2,5.5,53.07,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR1C","ENSG00000171453","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase; Cytosolic DNA-sensing pathway",790.8,875.9,808.1,833.5,853.4,833.6,0.9818686768498314,-0.026398015283089476,0.6001201127574002,0.2217618178045073,0.7599315342863738,0.11922553353636131,6166]
["High","O15162","phospholipid scramblase 1 [OS=Homo sapiens]",9,2,2,2,318,35,4.94,2.44,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;transporter activity;nucleic acid binding activity;other molecular function","PLSCR1","ENSG00000188313","EGF/EGFR signaling pathway; Complement system in neuronal development and plasticity","","",69.5,71.2,71.1,71.9,64,65.9,1.0495540138751238,0.06977641488597913,0.24424343005405483,0.6121771096138797,0.44236898674601255,0.3542153278091324,4311]
["High","O15164","Transcription intermediary factor 1-alpha [OS=Homo sapiens]",29,19,35,18,1050,116.8,7.11,75.15,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function","TRIM24","ENSG00000122779","","Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",765.5,733.1,807.7,956.8,880.8,847.9,0.8587972444609944,-0.21961053271819847,0.031174742501196097,1.5061971250433728,0.12540566174618192,0.9016828557731001,1941]
["Medium","O15169","Axin-1 [OS=Homo sapiens]",1,1,1,1,862,95.6,6.96,1.89,"cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","AXIN1","ENSG00000103126","Alzheimer's disease and miRNA effects; Neural crest differentiation; Mesodermal commitment pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Wnt signaling pathway; TGF-beta signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)","Ub-specific processing proteases; Degradation of AXIN; Estrogen-dependent gene expression; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling","Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Colorectal cancer; Endometrial cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",38.4,44.1,52.6,54.6,42.4,49.6,0.9215552523874488,-0.11785742880812734,0.5196571121668031,0.2842831244661272,0.7015011638655599,0.15397160409396618,5784]
["High","O15173","Membrane-associated progesterone receptor component 2 [OS=Homo sapiens]",52,12,38,10,223,23.8,4.88,90.01,"transport;developmental processes;signal transduction","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","PGRMC2","ENSG00000164040","Ciliary landscape","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","",641.7,617.8,652,687.5,654,686.9,0.942368369157957,-0.08563697934462423,0.0602285847549704,1.220197341716156,0.18893723976167492,0.7236824336661137,2489]
["High","O15182","Centrin-3 [OS=Homo sapiens]",34,5,6,5,167,19.5,4.74,10.29,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","CETN3","ENSG00000153140","Breast cancer pathway","","",329.4,373.8,294.9,402.5,312.1,315.7,0.9687469669028438,-0.04580820661036459,0.7880834481195499,0.10342779375531522,0.8834681353793892,0.053809109856662096,6965]
["High","O15194-1","CTD small phosphatase-like protein [OS=Homo sapiens]",11,3,4,2,276,31.1,5.54,2.79,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","CTDSPL","ENSG00000144677; ENSPTRG00000014749","","","",105.3,100.1,119,137.4,143.6,135.2,0.7794329649207112,-0.3595031455180616,0.007719678378946018,2.1124007930785953,0.05627941062820776,1.2496504592518156,1071]
["High","O15213","WD repeat-containing protein 46 [OS=Homo sapiens]",26,15,25,15,610,68,9.67,52.8,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","WDR46","ENSG00000204221; ENSG00000206284; ENSG00000226916; ENSG00000227057; ENSG00000236222","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",568.4,578.6,562.4,645.1,621.8,692.8,0.8722763688319641,-0.19714278927413598,0.017624583165588584,1.7538811456004197,0.08935892555643875,1.0488620617782474,1540]
["High","O15226","NF-kappa-B-repressing factor [OS=Homo sapiens]",36,22,44,22,690,77.6,8.79,73.45,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","NKRF","ENSG00000186416","Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway","","",2474.9,2259.1,2515.9,2342.8,2220.8,2300.2,1.0562516390337713,0.07895358009215597,0.21445567518770026,0.6686624564424426,0.4087063490030665,0.38858861573694947,4097]
["High","O15228","Dihydroxyacetone phosphate acyltransferase [OS=Homo sapiens]",26,16,30,16,680,77.1,6.57,55.14,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","other molecular function","GNPAT","ENSG00000116906","Triacylglyceride synthesis","Peroxisomal protein import; Plasmalogen biosynthesis; Synthesis of PA","Glycerophospholipid metabolism; Peroxisome",1065.5,1164.5,1082.7,1077.8,1096.5,1070,1.0210831304133403,0.030100326502568775,0.5096982863955389,0.2926868265058821,0.6929695664594059,0.1592858381284132,5743]
["High","O15230","Laminin subunit alpha-5 [OS=Homo sapiens]",11,31,40,31,3695,399.5,7.02,79.53,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;extracellular structural activity","LAMA5","ENSG00000130702","Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Malignant pleural mesothelioma","Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer",1547.5,1464.6,1582.1,1653.2,1575.2,1604.1,0.9506880496637351,-0.07295606929325144,0.12908043943691871,0.8891395647687207,0.2992458643478211,0.5239718429376972,3368]
["High","O15231-1","zinc finger protein 185 [OS=Homo sapiens]",4,3,4,2,689,73.5,7.01,8.4,"","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ZNF185","ENSG00000147394","","","",210.7,188.1,207.3,192.8,174.3,170.4,1.127627906976744,0.17329108784426978,0.08122717407287926,1.0902986557882262,0.22522080083843796,0.6473915015996653,2816]
["High","O15231-2","Isoform 2 of Zinc finger protein 185 [OS=Homo sapiens]",4,2,3,1,452,48.6,5.43,4.51,"","","","ZNF185","","","","",99.2,112.6,120.9,103.1,96.4,78.2,1.198055455527548,0.2606946890640205,0.13359681664540796,0.8742038901374526,0.30482873885661754,0.5159440906838987,3422]
["High","O15234","Protein CASC3 [OS=Homo sapiens]",10,6,6,6,703,76.2,6.48,15.76,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CASC3","ENSG00000108349","","Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Nucleocytoplasmic transport; mRNA surveillance pathway",406.9,362.1,447.2,497.8,446.1,499.7,0.842477140482128,-0.24729055370917766,0.06609371835240717,1.1798398145616122,0.1994048504233366,0.7002642818996396,2588]
["High","O15235","28S ribosomal protein S12, mitochondrial [OS=Homo sapiens]",24,2,3,2,138,15.2,10.29,10.61,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS12","ENSG00000128626; ENSG00000283018","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",65.6,57.3,53,56.7,64.5,60.5,0.9680792515134837,-0.046802936762154856,0.6783179970257756,0.16856666014963578,0.8163235081345954,0.08813769669410003,6488]
["High","O15240","Neurosecretory protein VGF [OS=Homo sapiens]",29,17,38,17,615,67.2,4.78,79.58,"cell-cell signaling;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;ER/Golgi;other cell component","signal transduction activity or receptor binding","VGF","ENSG00000128564","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; NGF-stimulated transcription","",2106.4,1513.3,1250.7,375.9,351.2,302,4.73267903993781,2.24265708493469,7.2782583940595455E-3,2.1379725300740233,0.05443356469426909,1.2641332240816312,1044]
["High","O15243","Leptin receptor gene-related protein [OS=Homo sapiens]",18,3,4,3,131,14.2,6.51,5.11,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding","LEPROT","ENSG00000213625","","","",246.8,276.8,272.9,345.3,314.5,301,0.8289966694421316,-0.27056178929296193,0.027455581452572892,1.5613693543960565,0.11695208946082332,0.9319920146996378,1833]
["High","O15254","Peroxisomal acyl-coenzyme A oxidase 3 [OS=Homo sapiens]",13,5,7,5,700,77.6,7.25,11.54,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOX3","ENSG00000087008","PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","Fatty acid degradation; beta-Alanine metabolism; alpha-Linolenic acid metabolism; Propanoate metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; PPAR signaling pathway; cAMP signaling pathway; Peroxisome; Alcoholic liver disease",41.7,54.5,57.2,49.8,44.2,51.7,1.0528483184625945,0.07429760543842104,0.6525660246967602,0.18537554113781934,0.7980008646565863,0.09799663807861805,6385]
["High","O15258","Protein RER1 [OS=Homo sapiens]",14,2,5,2,196,22.9,9.54,7.25,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","RER1","ENSG00000157916","","","",207.9,182,212.4,200.9,184.4,208.1,1.0149983147960904,0.02147733210272582,0.8136904576180475,0.08954077707078213,0.8992632828141139,0.046113138596724126,7065]
["High","O15260-1","surfeit locus protein 4 [OS=Homo sapiens]",17,4,16,4,269,30.4,7.78,29.12,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","SURF4","ENSG00000148248; ENSG00000280951; ENSGGOG00000014456; ENSNLEG00000013096; ENSPTRG00000021519","","COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation","",451.1,472.6,413.4,398.8,443.6,425.3,1.054744813441666,0.07689399332603837,0.3453661285358704,0.4617202577103262,0.5477592385959935,0.26141028882444645,4923]
["Medium","O15265","Ataxin-7 [OS=Homo sapiens]",2,1,1,1,892,95.4,9.85,2.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","","ATXN7","ENSG00000163635","","Ub-specific processing proteases; HATs acetylate histones","",18.7,21.6,15.5,18.6,16.3,22.1,0.9789473684210523,-0.030696797222916877,0.8776622781439197,0.056672567185160214,0.9346408984925975,0.029355218816703915,7332]
["High","O15269","serine palmitoyltransferase 1 [OS=Homo sapiens]",31,14,50,14,473,52.7,6.01,111.29,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC1","ENSG00000090054","Sphingolipid pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",1772.5,1853.8,1824.6,1506.4,1535.7,1534.4,1.1910630394406205,0.25224977280030714,3.4079760448318979E-4,3.4675034666148106,0.014540697791282765,1.8374147516866046,183]
["High","O15270","Serine palmitoyltransferase 2 [OS=Homo sapiens]",18,8,17,8,562,62.9,7.78,38.64,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC2","ENSG00000100596","Sphingolipid pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",568.4,608.3,585.8,434.3,453.8,448.8,1.318348417981898,0.39873170150397014,3.9388143077483768E-4,3.4046344931743966,0.015454403072813731,1.8109477649254677,199]
["High","O15287","Fanconi anemia group G protein [OS=Homo sapiens]",12,5,6,5,622,68.5,5.47,11.98,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus","nucleic acid binding activity","FANCG","ENSG00000221829","Retinoblastoma gene in cancer; DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",48.4,46.5,34.6,53.1,70.4,47.8,0.7559836544074722,-0.40357305351008294,0.15953544805277114,0.7971428036209175,0.3429660733469265,0.4647488388113296,3632]
["High","O15294","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit [OS=Homo sapiens]",11,12,27,12,1046,116.9,6.7,58.4,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","OGT","ENSG00000147162","Ectoderm differentiation; Ectoderm differentiation; Malignant pleural mesothelioma","UCH proteinases; Regulation of necroptotic cell death; HATs acetylate histones","Other types of O-glycan biosynthesis; Insulin resistance",986.9,1049.5,1027.2,1320.7,1282.9,1316.9,0.7814309399311312,-0.35580971625146657,1.9975431149736925E-4,3.699503838100036,0.011468247530672493,1.9405029418116184,136]
["High","O15305","Phosphomannomutase 2 [OS=Homo sapiens]",38,10,42,10,246,28.1,6.77,55.91,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PMM2","ENSG00000140650","Nephrotic syndrome","Defective PMM2 causes PMM2-CDG (CDG-1a); Synthesis of GDP-mannose","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",2160.8,2065.8,2218.7,2329.4,2112,2210.9,0.9688829427416084,-0.0456057204001632,0.42109077454572824,0.37562427320279784,0.6174416465076142,0.20940408065493782,5325]
["High","O15318","DNA-directed RNA polymerase III subunit RPC7 [OS=Homo sapiens]",14,3,3,3,223,25.9,4.63,5.5,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","POLR3G","ENSG00000113356","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",68.2,68.7,71.8,114,91.9,87.7,0.7108310626702996,-0.49242136768337796,0.02637299270826584,1.5788405853017677,0.11414652276393551,0.9425373138490551,1804]
["High","O15320","Endoplasmic reticulum export factor CTAGE5 [OS=Homo sapiens]",25,18,32,18,804,90.9,5.22,81.02,"","","","","","","","",1652.7,1536.1,1686.3,1908,1805.5,1803.5,0.8836505347108937,-0.17845216816785123,0.020010485450189762,1.6987423753427338,0.09573644019306475,1.0189227251019408,1632]
["High","O15321-1","Transmembrane 9 superfamily member 1 [OS=Homo sapiens]",5,3,3,3,606,68.8,7.17,4.2,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","TM9SF1","ENSCANG00000029500; ENSCCAG00000032112; ENSG00000100926; ENSG00000285465; ENSPPAG00000042444; ENSPTRG00000032568; ENSRBIG00000029944; ENSRROG00000042511","","","",123.1,113.5,131.6,130.8,131.9,136.4,0.9225757955399649,-0.11626065216136507,0.13449736082059513,0.8712862375373925,0.306257040911988,0.5139139179937013,3429]
["High","O15344-1","E3 ubiquitin-protein ligase Midline-1 [OS=Homo sapiens]",26,16,36,16,667,75.2,6.8,95.44,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","MID1","ENSCANG00000031338; ENSCCAG00000029160; ENSCJAG00000000987; ENSCSAG00000015273; ENSG00000101871; ENSMFAG00000037182; ENSMLEG00000034816; ENSMMUG00000020179; ENSMNEG00000026727; ENSPANG00000006683; ENSPPAG00000038224; ENSRBIG00000037000; ENSTSYG00000003295","","Interferon gamma signaling","Ubiquitin mediated proteolysis",1391.5,1451.5,1436.3,1609.7,1718.6,1674.8,0.855329695588735,-0.22544746610874278,2.6886288872182483E-3,2.5704691395231127,0.03175917451043885,1.4981307943501176,661]
["High","O15347","High mobility group protein B3 [OS=Homo sapiens]",13,2,5,2,200,23,8.37,4.96,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","HMGB3","ENSG00000029993","","","",156.8,164.8,120.4,213.3,158.7,108.8,0.9193011647254575,-0.12139052643239158,0.7161187490754454,0.1450149556362241,0.8418330612437634,0.0747740222399552,6642]
["High","O15355","Protein phosphatase 1G [OS=Homo sapiens]",56,25,161,25,546,59.2,4.36,383.7,"protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","PPM1G","ENSG00000115241","VEGFA-VEGFR2 signaling pathway; mRNA processing","","",5770.6,5610.5,6004.2,5994.7,5335.9,5694.1,1.0211809899733917,0.030238586290505517,0.6170989277444365,0.2096452082041178,0.774025450253584,0.11124475931325634,6225]
["High","O15357","Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [OS=Homo sapiens]",18,18,39,18,1258,138.5,6.54,88.27,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","INPPL1","ENSG00000165458","EGF/EGFR signaling pathway; Insulin signaling","Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; B cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway",1371.5,1372.6,1452.5,1608.1,1491.6,1618.7,0.8894116649711767,-0.16907676858144816,0.023426710432140035,1.6302886905523886,0.10554861803470825,0.9765474486076702,1733]
["High","O15360","Fanconi anemia group A protein [OS=Homo sapiens]",6,5,6,5,1455,162.7,6.6,5.61,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","","FANCA","ENSG00000187741","DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",26.9,28,26.4,27.2,24.6,31,0.9818840579710145,-0.026375415424297447,0.8071510172361862,0.09304520156488294,0.8945685085280541,0.048386394351622806,7045]
["High","O15371","Eukaryotic translation initiation factor 3 subunit D [OS=Homo sapiens]",51,21,82,21,548,63.9,6.05,173.31,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3D","ENSG00000100353","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",2592,2608.7,2566.6,2622.5,2659.1,2722.2,0.9704515355206277,-0.04327192853256998,0.06706255240555349,1.1735199213135143,0.20085324479576588,0.6971211478232078,2607]
["High","O15372","Eukaryotic translation initiation factor 3 subunit H [OS=Homo sapiens]",55,16,78,16,352,39.9,6.54,148.32,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3H","ENSG00000147677","Translation factors; VEGFA-VEGFR2 signaling pathway; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Measles",4058.5,4336.4,3869.7,4251.1,4263.7,4201.6,0.9644710767198261,-0.05219012058244355,0.33292849636138444,0.47764903066836484,0.5344378494222224,0.272102792274408,4864]
["High","O15379","Histone deacetylase 3 [OS=Homo sapiens]",9,4,8,4,428,48.8,5.16,16.06,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","HDAC3","ENSG00000171720","Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome","Cytoprotection by HMOX1; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling","Neutrophil extracellular trap formation; Thyroid hormone signaling pathway; Alcoholism; Viral carcinogenesis",355.3,414.3,357.9,360.3,390.1,389.1,0.9894690653795525,-0.015273491122553754,0.862006397718351,0.06448951087660305,0.9261794348954018,0.0333048664112277,7267]
["High","O15381-1","Nuclear valosin-containing protein-like [OS=Homo sapiens]",39,28,85,28,856,95,6.48,180.61,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","NVL","ENSG00000143748","","","Ribosome biogenesis in eukaryotes",2618.8,2518.9,2615.5,3063.6,2987.6,3018.3,0.8548652075638129,-0.22623113653759197,3.7389896938387884E-4,3.427245731934604,0.015126441206991326,1.8202632362837425,193]
["High","O15397-1","Importin-8 [OS=Homo sapiens]",19,15,32,14,1037,119.9,5.16,74.12,"transport;signal transduction","cytosol;nucleus","other molecular function","IPO8","ENSG00000133704","","Transcriptional regulation by small RNAs","Nucleocytoplasmic transport",799.7,810,814.7,853.8,936.5,945.8,0.8860787251927927,-0.174493211683098,0.024599624238310497,1.6090715267370532,0.10907090633317908,0.9622910780456948,1761]
["High","O15400","Syntaxin-7 [OS=Homo sapiens]",39,7,19,7,261,29.8,5.55,35.83,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STX7","ENSG00000079950","","","SNARE interactions in vesicular transport; Phagosome",374.4,346.5,398.1,327.9,356.8,332.5,1.1000786472670074,0.13760666917365,0.12292610932473227,0.9103558638070828,0.29085062472954837,0.5363299990263348,3300]
["Low","O15417-1","Trinucleotide repeat-containing gene 18 protein [OS=Homo sapiens]",0,1,2,1,2968,314.3,8.7,2.13,"","other membranes;cytosol;mitochondrion;nucleus","other molecular function","TNRC18","ENSG00000182095","","","",135.9,175.3,126.7,124.7,151.4,140.9,1.0501199040767386,0.07055406612062506,0.6997655978518854,0.15504741228229943,0.828974326813461,0.08145891926383678,6591]
["Medium","O15427","Monocarboxylate transporter 4 [OS=Homo sapiens]",2,1,1,1,465,49.4,7.96,2.4,"transport","plasma membrane;other membranes;nucleus;other cell component","transporter activity","SLC16A3","ENSG00000141526","Metabolic reprogramming in colon cancer","Pyruvate metabolism; Basigin interactions; Proton-coupled monocarboxylate transport","Central carbon metabolism in cancer",142.8,144.6,117.6,67.5,49.2,51.2,2.4121500893388923,1.2703196777223194,1.6480545211943402E-3,2.7830284250040846,0.026808353544761267,1.5717298577210366,480]
["Medium","O15431","High affinity copper uptake protein 1 [OS=Homo sapiens]",6,1,2,1,190,21.1,7.42,5.3,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","SLC31A1","ENSG00000136868","Copper homeostasis","Metal ion SLC transporters","Platinum drug resistance; Mineral absorption",84.6,81.4,85.7,78.9,85.4,87.7,0.9988095238095237,-1.7185172262995478E-3,0.9744413055777228,0.011244315018806563,0.9869552100078947,0.00570255603127052,7709]
["High","O15439-1","multidrug resistance-associated protein 4 [OS=Homo sapiens]",10,9,10,9,1325,149.4,8.19,16.16,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","ABCC4","ENSG00000125257","Fluoropyrimidine activity; Drug induction of bile acid pathway; Ectoderm differentiation; Pregnane X receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; TYROBP causal network in microglia; Aspirin and miRNAs; Proximal tubule transport; FOXA2 pathway; Prostaglandin synthesis and regulation","ABC-family proteins mediated transport; Platelet degranulation","Antifolate resistance; ABC transporters; cAMP signaling pathway; Bile secretion",217.2,229.3,228.3,245.1,251.4,260.2,{"$f":"AVERAGE(T322:V322)/AVERAGE(W322:Y322)","v":0.8917668825161885},{"$f":"LOG(Z322,2)","v":-0.16526147150468895},{"$f":"TTEST(T322:V322,W322:Y322,2,2)","v":9.535392612574212E-3},{"$f":"-LOG10(AB322)","v":2.020661420503224},{"$f":"AB322*7808/AF322","v":0.06379806813965676},{"$f":"-LOG10(AD322)","v":1.1951924718899585},1167]
["High","O15440","Multidrug resistance-associated protein 5 [OS=Homo sapiens]",9,8,12,8,1437,160.6,8.66,25.56,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","ABCC5","ENSG00000114770","Fluoropyrimidine activity; Nuclear receptors meta-pathway; NRF2 pathway","ABC-family proteins mediated transport; Hyaluronan biosynthesis and export","Antifolate resistance; ABC transporters",199.6,220.8,198,175.9,168,162.2,1.2218929065402095,0.28911784491612563,0.01097292061959585,1.9596777625660824,0.06931760857427541,1.1591564286602438,1236]
["High","O15446-1","DNA-directed RNA polymerase I subunit RPA34 [OS=Homo sapiens]",10,3,3,3,510,55,8.51,5.83,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytosol;mitochondrion;nucleus;other cell component","other molecular function","POLR1G","ENSG00000117877","","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase",124.7,64.5,71.6,198,68.1,54.9,0.8124610591900311,-0.2996294277785881,0.705675012136815,0.15139526060643446,0.8336980624548724,0.07899120781822912,6609]
["High","O15460-1","Prolyl 4-hydroxylase subunit alpha-2 [OS=Homo sapiens]",13,6,8,6,535,60.9,5.71,16.6,"protein metabolism;other metabolic processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","P4HA2","ENSG00000072682","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","Arginine and proline metabolism; Metabolic pathways",514,524.1,526.8,580.7,593.9,579.3,0.8922401505216945,-0.16449602449923717,4.8554883350144184E-4,3.313767084903903,0.01627109567373072,1.7885832012712866,233]
["High","O15484","calpain-5 [OS=Homo sapiens]",28,13,18,13,640,73.1,7.64,34.33,"protein metabolism;signal transduction","other cell component","other molecular function","CAPN5","ENSG00000149260","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",941.5,983.9,914.8,695.3,734.1,730.9,1.3147248067398045,0.39476085160865443,6.6274984005213074E-4,3.1786503684073706,0.01809353409484978,1.742476596877778,286]
["High","O15488-1","Glycogenin-2 [OS=Homo sapiens]",10,4,10,4,501,55.1,5.1,27.53,"other metabolic processes","cytosol;other cell component","other molecular function","GYG2","ENSG00000056998","Glycogen synthesis and degradation","Glycogen synthesis; Glycogen storage disease type 0 (liver GYS2); Glycogen storage disease type IV (GBE1); Glycogen breakdown (glycogenolysis)","Starch and sucrose metabolism; Metabolic pathways",762,795.5,777.9,776,774.1,814.3,0.9877347318558621,-0.017804454313195356,0.5846379846153944,0.23311297144017554,0.7487048358007217,0.12568936180346013,6097]
["High","O15498","Synaptobrevin homolog YKT6 [OS=Homo sapiens]",34,7,37,7,198,22.4,6.92,81.66,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","YKT6","ENSG00000106636","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport","SNARE interactions in vesicular transport",1871.7,1982.2,1922.7,1650.7,1675.7,1691.6,1.1511757672379435,0.20310812813802512,1.7603029836637466E-3,2.754412574908305,0.027488891392893067,1.560842774585688,500]
["High","O15504","nucleoporin-like protein 2 [OS=Homo sapiens]",17,7,10,7,423,44.8,9.19,20.54,"transport","other membranes;cytosol;nucleus","other molecular function","NUP42","ENSG00000136243","","HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus","Nucleocytoplasmic transport",349.6,331.6,334.8,377.7,322.1,364.1,0.9549769715198796,-0.06646215071765578,0.4162966284506805,0.3805971064113113,0.6142184570942769,0.21167713726813922,5292]
["High","O15511-1","Actin-related protein 2/3 complex subunit 5 [OS=Homo sapiens]",40,4,5,4,151,16.3,5.67,16.5,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","Arpc5; ARPC5","ENSDLEG00000020693; ENSG00000162704; ENSGGOG00000007894; ENSPCTG00005002795; ENSPPAG00000038421; ENSPPYG00000000425; ENSPTRG00000001767; ENSRNOG00000028062; ENSSBOG00000027275; ENSSSCG00000015560; ENSSSCG00070012419; ENSSTOG00000001001","Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton","Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Neutrophil degranulation; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",81.5,90.7,85.9,111.9,95,93.3,0.8597601598934046,-0.21799383552671822,0.09715481501109113,1.0125356708137832,0.2516870589272062,0.5991391141337609,3014]
["High","O15514","DNA-directed RNA polymerase II subunit RPB4 [OS=Homo sapiens]",11,1,3,1,142,16.3,4.79,2.94,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","POLR2D","ENSG00000144231","Pyrimidine metabolism","Estrogen-dependent gene expression; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; mRNA Splicing - Major Pathway; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere","RNA polymerase; Huntington disease",23.1,31,20.4,38.3,23.7,18.6,0.924317617866005,-0.11353941317844343,0.7768251660391721,0.10967671346191277,0.8762569916835966,0.05736850376138625,6922]
["High","O15523","atp-dependent rna helicase ddx3y [OS=Homo sapiens]",60,37,183,9,660,73.1,7.55,381.16,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX3Y","ENSG00000067048","Novel intracellular components of RIG-I-like receptor (RLR) pathway","","",809.2,864.2,814.4,756,809,772,1.0645271715875055,0.09021277441609482,0.09950507136472467,1.002154784484532,0.2551512634534549,0.5932022767947909,3045]
["Medium","O15525","transcription factor MafG [OS=Homo sapiens]",6,1,2,1,162,17.8,10.04,2.33,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","MAFG","ENSG00000197063","Quercetin and Nf-kB / AP-1 induced apoptosis; Nuclear receptors meta-pathway; NRF2 pathway; Ethanol metabolism production of ROS by CYP2E1","Factors involved in megakaryocyte development and platelet production","",133.2,151,123.4,146.3,129.3,129.7,1.0056748087836171,0.00816387611897322,0.941580271123697,0.02614264981614658,0.97041430265758,0.013042811152728203,7576]
["Medium","O15527-1","N-glycosylase/DNA lyase [OS=Homo sapiens]",3,1,1,1,345,38.8,8.6,2.96,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","OGG1","ENSG00000114026","Base excision repair; DNA repair pathways, full network","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Defective OGG1 Substrate Binding; Defective OGG1 Substrate Processing","Base excision repair",142.5,131.7,115.6,131.1,147.9,144.9,0.9195564991743335,-0.12098987579720574,0.2919368209438069,0.5347111255525155,0.49274593556620067,0.3073769493284808,4626]
["High","O15530-1","3-phosphoinositide-dependent protein kinase 1 [OS=Homo sapiens]",10,5,8,5,556,63.1,7.36,12.47,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function","PDPK1","ENSG00000140992","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; Serotonin HTR1 group and FOS pathway","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of TP53 Degradation; PIP3 activates AKT signaling; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ","Platinum drug resistance; PPAR signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Thyroid hormone signaling pathway; Insulin resistance; Aldosterone-regulated sodium reabsorption; Toxoplasmosis; Proteoglycans in cancer; Chemical carcinogenesis; Endometrial cancer; Prostate cancer; Non-small cell lung cancer; Choline metabolism in cancer; Lipid and atherosclerosis",393.9,349.7,402,304.7,285.9,297.7,1.2896543960373748,0.3669845013655464,0.007490325820199785,2.1254992905999686,0.05517402264539615,1.2582653512061033,1060]
["High","O15540","Fatty acid-binding protein, brain [OS=Homo sapiens]",22,2,4,2,132,14.9,5.59,9.22,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus","other molecular function","FABP7","ENSG00000164434","PPAR signaling pathway; Fatty acid transporters","Triglyceride catabolism; NOTCH3 Intracellular Domain Regulates Transcription","PPAR signaling pathway",198.7,172.5,187.6,155.7,150.9,137.6,1.2579918955425482,0.3311226278624822,0.01489543391289024,1.826946841006906,0.08116088485125401,1.090653226745615,1433]
["High","O15541","RING finger protein 113A [OS=Homo sapiens]",22,5,10,5,343,38.8,5.69,21.61,"protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","RNF113A","ENSG00000125352","","","",431.5,399.5,446.9,456,382.5,435.2,1.0032974797833085,0.004749431450163916,0.9595601811124865,0.01792778225685829,0.9805321154464461,0.008538177281500433,7641]
["High","O15550","Lysine-specific demethylase 6A [OS=Homo sapiens]",8,9,11,9,1401,154.1,7.44,21.8,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6A","ENSG00000147050","Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Malignant pleural mesothelioma","Activation of anterior HOX genes in hindbrain development during early embryogenesis; HDMs demethylate histones","Transcriptional misregulation in cancer",254.5,243.2,245.9,308.3,259.4,276.1,0.8812514813936951,-0.18237431729986953,0.08625236464904998,1.0642289897044657,0.2335964145611454,0.6315338274340381,2883]
["Medium","O15554","intermediate conductance calcium-activated potassium channel protein 4 [OS=Homo sapiens]",3,1,1,1,427,47.7,9.83,0,"cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","KCNN4","ENSG00000104783","","Ca2+ activated K+ channels","Insulin secretion; GnRH secretion; Salivary secretion; Protein digestion and absorption",213.7,261.2,128.3,159.3,259.8,202.1,0.9710238248551192,-0.042421401118636834,0.9076548256105451,0.04207927904867766,0.9510156841609146,0.0218123206142473,7452]
["High","O43143","Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [OS=Homo sapiens]",51,42,253,42,795,90.9,7.46,499.59,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","DHX15","ENSG00000109606","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",9571.5,10134.4,9421.8,10102.2,10994.8,10322.3,0.9270639384072847,-0.10925925178404618,0.09131579287792833,1.039454105635479,0.24177474085821105,0.6165890735286416,2949]
["High","O43148-1","mRNA cap guanine-N7 methyltransferase [OS=Homo sapiens]",32,18,46,17,476,54.8,6.61,90.23,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNMT","ENSG00000101654","mRNA processing","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA surveillance pathway",2549.6,2481.3,2590.7,2722.4,2573.6,2665.3,0.9573310891437328,-0.06291013354313316,0.10318211830400623,0.9863955604102054,0.2603056477278451,0.5845164091077069,3095]
["High","O43149","Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",2,5,6,3,2961,330.9,5.95,4.67,"","","other molecular function","ZZEF1","ENSG00000074755","","","",199.3,203.6,191.2,222.7,222,204.4,0.9152672931751654,-0.1277349676387672,0.05894985778649111,1.2295172382807946,0.1866506446054025,0.7289705058818722,2466]
["High","O43149-3","Isoform 3 of Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",2,3,3,1,1085,119.9,5.67,5.48,"","","","ZZEF1","","","","",64.6,83.9,64.1,80.3,81.9,74,0.9000846740050803,-0.15186736786605282,0.32093443338581057,0.49358368450251794,0.522162128751075,0.2821946297763039,4799]
["High","O43150-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [OS=Homo sapiens]",7,6,8,6,1006,111.6,6.68,19.9,"other biological processes","plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","ASAP2","ENSG00000151693","Vitamin D receptor pathway","","Endocytosis; Fc gamma R-mediated phagocytosis",338.5,318.6,334.9,331.3,374.3,336.5,0.9519239996161599,-0.07108169966688299,0.3242267513433098,0.48915115518311875,0.5255475346665067,0.2793879968389174,4817]
["High","O43156","TELO2-interacting protein 1 homolog [OS=Homo sapiens]",10,9,12,9,1089,122,5.97,23.39,"other biological processes","nucleus;other cell component","","TTI1","ENSG00000101407","Fragile X syndrome; Malignant pleural mesothelioma","","mTOR signaling pathway",379.7,441.8,383.7,397.8,488.1,427.9,0.9173390165930887,-0.12447309261581117,0.3378217008425677,0.4713124558500662,0.5392990881575891,0.2681703140127132,4891]
["High","O43157","Plexin-B1 [OS=Homo sapiens]",8,11,15,11,2135,232.2,5.49,34.98,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PLXNB1","ENSG00000164050","","RHOD GTPase cycle; G alpha (12/13) signalling events; Sema4D induced cell migration and growth-cone collapse; Sema4D mediated inhibition of cell attachment and migration","Axon guidance",382.4,377.6,383.9,337.7,384.5,365.3,1.0518620689655174,0.0729455359364561,0.2423208898698134,0.615609144821949,0.4400096530473263,0.3565377957429,4300]
["High","O43159","ribosomal rna-processing protein 8 [OS=Homo sapiens]",22,8,17,8,456,50.7,9.42,31.67,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RRP8","ENSG00000132275","","SIRT1 negatively regulates rRNA expression","",695.5,721.9,715.5,774.5,689.5,706.5,0.9826768025800507,-0.02521109539615335,0.668421550857695,0.17494955628359074,0.8094037638177547,0.09183478042198956,6448]
["High","O43164","E3 ubiquitin-protein ligase Praja-2 [OS=Homo sapiens]",19,8,12,7,708,78.2,4.39,16.29,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","PJA2","ENSG00000198961","","Antigen processing: Ubiquitination & Proteasome degradation","",137.5,148.9,140.7,228.4,183.8,181.4,0.7195080862533692,-0.4749171939786618,0.02390102461279174,1.6215834808868663,0.10682266753101197,0.971336581211162,1747]
["High","O43166-1","Signal-induced proliferation-associated 1-like protein 1 [OS=Homo sapiens]",3,5,5,5,1804,199.9,8.19,7.08,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","SIPA1L1","ENSG00000197555","","Neurexins and neuroligins","Rap1 signaling pathway",453.9,426.4,432.8,450.3,470,465.8,0.947334247168314,-0.0780545544607736,0.07634596368458607,1.1172139186055796,0.21700374388396362,0.6635327733675062,2747]
["High","O43167-1","Zinc finger and BTB domain-containing protein 24 [OS=Homo sapiens]",6,4,5,4,697,78.2,7.61,11.48,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB24","ENSG00000112365","","","",138.4,124,143.4,142.6,148.8,138.4,0.944160074453234,-0.0828966176711246,0.28919856123299514,0.5388038719934309,0.4902436747953161,0.30958800096300787,4606]
["High","O43169","Cytochrome b5 type B [OS=Homo sapiens]",64,6,33,6,146,16.3,4.97,87.14,"","other membranes","other molecular function","","","","","",958.1,1052.5,1015.2,929.5,1100.5,933.6,1.0209879875826697,0.029965892310855995,0.7573435476251749,0.12070707031184012,0.8655354830001998,0.0627151233341534,6832]
["High","O43172-2","Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",37,16,46,16,521,58.3,7.42,115.97,"","","","PRPF4","","","","",1891.1,1908.3,1962.2,1906.1,1836.5,1918.3,1.017788690844212,0.025438066015470228,0.3702666573482969,0.4314853945711777,0.5725969618885922,0.24215096060802854,5049]
["High","O43175","D-3-phosphoglycerate dehydrogenase [OS=Homo sapiens]",65,24,440,24,533,56.6,6.71,1021.72,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PHGDH","ENSG00000092621","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",13385.1,13507.8,13809,13721.8,13612.2,13820.3,0.9890072240324826,-0.015947035947693408,0.3406402125001401,0.4677040849815821,0.5425782903307005,0.26553758723900583,4902]
["High","O43181","NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [OS=Homo sapiens]",17,3,8,3,175,20.1,10.3,11.75,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity","NDUFS4","ENSG00000164258","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",249.2,283,272,313.4,312,305.9,0.8635241060882637,-0.21169164238091942,0.014295280085567538,1.8448073311472095,0.07927382592905635,1.1008701812946675,1408]
["High","O43237","Cytoplasmic dynein 1 light intermediate chain 2 [OS=Homo sapiens]",24,9,23,9,492,54.1,6.38,49.13,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYNC1LI2","ENSG00000135720","Intraflagellar transport proteins binding to dynein","COPI-mediated anterograde transport; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection",568.1,569.5,558.6,507.4,515.4,489.9,1.121306273550605,0.16518038963522028,0.001783427776539998,2.7487444735895763,0.027574265503414463,1.5594960470496024,505]
["High","O43242","26S proteasome non-ATPase regulatory subunit 3 [OS=Homo sapiens]",52,26,184,26,534,60.9,8.44,350.11,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity","PSMD3","ENSG00000108344","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Ub-specific processing proteases; Degradation of beta-catenin by the destruction complex; Degradation of AXIN; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",6231.3,6289.6,6147,5895.7,6381,6194.2,1.0106654250740355,0.01530548045213068,0.6787308684575821,0.16830239878858647,0.8164428625661379,0.08807420326107487,6491]
["High","O43251-8","Isoform 8 of RNA binding protein fox-1 homolog 2 [OS=Homo sapiens]",13,4,13,4,451,47.3,6.62,36.56,"","","","RBFOX2","","","","",189.4,209.5,206.4,273.5,256.7,255,0.770886398369842,-0.3754098217559734,2.2202552981149164E-3,2.6535970849242276,0.02999265288526171,1.5229851186861212,578]
["High","O43252","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [OS=Homo sapiens]",51,23,86,22,624,70.8,6.86,180.9,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS1","ENSG00000138801","Sulfation biotransformation reaction","Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways",3413.4,3514.9,3472.1,3298.2,3419.5,3388.1,1.0291515763225079,0.04145548204162276,0.10365727154390891,0.9844002268009392,0.260746126357874,0.5837821347284546,3104]
["High","O43257","zinc finger HIT domain-containing protein 1 [OS=Homo sapiens]",15,1,1,1,154,17.5,9.41,2.48,"cell organization and biogenesis","nucleus","other molecular function","ZNHIT1","ENSG00000106400","","","",15.1,12.5,16,14.8,13.8,12.8,1.0531400966183573,0.07469736727760085,0.5734396501090666,0.24151228134378255,0.7409261605248374,0.13022507093360355,6043]
["High","O43264","Centromere/kinetochore protein zw10 homolog [OS=Homo sapiens]",29,17,52,17,779,88.8,6.27,88.63,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity","ZW10","ENSG00000086827","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",1403.3,1493.3,1391.5,1522.7,1573.8,1587.2,0.9155368618826997,-0.12731012106053047,0.02490015393049165,1.6037979681268948,0.10978001235984122,0.9594767246583341,1771]
["High","O43272","Proline dehydrogenase 1, mitochondrial [OS=Homo sapiens]",23,8,13,8,600,68,7.87,30.11,"other metabolic processes;stress response;signal transduction;other biological processes","other membranes;mitochondrion;nucleus;other cell component","other molecular function","PRODH","ENSG00000100033","22q11.2 copy number variation syndrome","Proline catabolism","Arginine and proline metabolism; Metabolic pathways",314.9,336.8,290,235.7,307.2,256.7,1.1777138569284644,0.235989057558644,0.13286469263388637,0.8765904128231737,0.30449296157481204,0.5164227417324158,3407]
["High","O43278","Kunitz-type protease inhibitor 1 [OS=Homo sapiens]",4,2,2,2,529,58.4,6.29,5.43,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","enzyme regulator activity","SPINT1","ENSG00000166145","","MET Receptor Activation; Signaling by MST1","Transcriptional misregulation in cancer; Prostate cancer",78.7,101.7,102.4,120.6,108.3,122.3,0.8052391799544419,-0.3125107247259593,0.06344560851629323,1.1975984328780938,0.1953404224350227,0.7092078774291535,2536]
["High","O43286","Beta-1,4-galactosyltransferase 5 [OS=Homo sapiens]",8,2,2,2,388,45.1,8.15,3.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","B4GALT5","ENSG00000158470","","N-Glycan antennae elongation; Keratan sulfate biosynthesis; O-linked glycosylation of mucins","Mucin type O-glycan biosynthesis; Metabolic pathways",31,35.8,35.5,65.1,81.1,80.9,0.45046235138705415,-1.150521560961559,1.6637487664588175E-3,2.7789122535129573,0.026895549417205893,1.570319579605834,483]
["High","O43290","U4/U6.U5 tri-snRNP-associated protein 1 [OS=Homo sapiens]",48,33,95,33,800,90.2,6.13,228.79,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","SART1","ENSG00000175467","","mRNA Splicing - Major Pathway","Spliceosome",3726.9,3491.8,3638,3804.8,3481.3,3661.3,0.9917149277454007,-0.012002622897434981,0.8072383923332628,0.09299819119386807,0.8945383717482424,0.048401025380456375,7046]
["High","O43291","Kunitz-type protease inhibitor 2 [OS=Homo sapiens]",20,4,7,4,252,28.2,8.29,13.65,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity","SPINT2","ENSG00000167642","","MET Receptor Activation; Signaling by MST1","",312.6,321.5,303.8,344.4,360.5,342.7,0.8952844597174496,-0.1595819505884834,0.00870993149879534,2.059985260585009,0.060290022289533715,1.2197545555736968,1128]
["High","O43293-1","Death-associated protein kinase 3 [OS=Homo sapiens]",26,8,16,8,454,52.5,6.89,29.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","DAPK3","ENSG00000167657; ENSPTRG00000010286","Bladder cancer","Caspase activation via Dependence Receptors in the absence of ligand","Autophagy; Pathways in cancer; Bladder cancer",437.8,422.8,444.1,419.8,395.1,385.5,1.0868877040986338,0.1202028905869361,0.04436804548675946,1.3529297025210254,0.15604761223451255,0.8067428723130287,2220]
["High","O43295","SLIT-ROBO Rho GTPase-activating protein 3 [OS=Homo sapiens]",2,2,2,2,1099,124.4,6.68,6.04,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity","SRGAP3","ENSG00000196220","","CDC42 GTPase cycle; RAC1 GTPase cycle; Inactivation of CDC42 and RAC1","Axon guidance",56.3,50.3,49.4,63.1,69.8,61,0.8045384218669417,-0.3137667743571818,0.021046612413744458,1.6768177966649738,0.09840236510569865,1.0069944631539216,1670]
["High","O43296","Zinc finger protein 264 [OS=Homo sapiens]",3,1,1,1,627,70.5,7.49,4.98,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF264","ENSG00000083844","","Generic Transcription Pathway","",29.3,26.1,24.1,16.3,8.2,20.5,1.7666666666666666,0.8210298589546806,0.04248242828010375,1.371790667102928,0.15187857143363098,0.8185034964769923,2184]
["High","O43298","Zinc finger and BTB domain-containing protein 43 [OS=Homo sapiens]",4,2,2,2,467,52.6,5.76,2.27,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB43","ENSG00000169155","","","",107.1,123.2,110.2,119.2,88.7,117.7,1.0457616707616706,0.06455409863318624,0.6772801438005442,0.16923165666037882,0.815954846905516,0.08833387345489443,6481]
["High","O43301","Heat shock 70 kDa protein 12A [OS=Homo sapiens]",8,4,7,4,675,74.9,6.77,0,"","nucleus;other cell component","other molecular function","HSPA12A","ENSG00000165868","","Regulation of HSF1-mediated heat shock response","",338.7,389.7,258.1,253.4,327.5,283.3,1.141518167090951,0.19095382002118727,0.4060445615976072,0.3914263019056593,0.60376993657477,0.2191285155340809,5251]
["High","O43303","centriolar coiled-coil protein of 110 kDa [OS=Homo sapiens]",6,4,4,4,1012,113.4,8.65,8.68,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cell component","","CCP110","ENSG00000103540","Joubert syndrome","Ub-specific processing proteases; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; RHOV GTPase cycle","",175,160.7,176.7,181.1,169.7,163.8,0.9957248348231637,-6.180981392153357E-3,0.9235437067137625,0.03454254674734534,0.959679167157447,0.017873932816075792,7514]
["High","O43310","CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",10,4,4,4,598,67.5,6.54,5.41,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","CTIF","ENSG00000134030; ENSG00000282825","","","",80,79.2,86.4,97.1,85.8,75.9,0.9489953632148378,-0.07552705662232802,0.537624495522572,0.2695209519558541,0.7141497211705073,0.14621072903381246,5878]
["High","O43314-1","inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 [OS=Homo sapiens]",12,12,15,12,1243,140.3,8.22,33.34,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","PPIP5K2","ENSG00000145725","","Synthesis of pyrophosphates in the cytosol","Phosphatidylinositol signaling system",658.1,672.6,657.4,722.5,718.4,706.1,0.9259897531439217,-0.11093186594854848,1.6241850348142882E-3,2.7893644954020114,0.026642094016449503,1.574431643463869,476]
["High","O43318","mitogen-activated protein kinase kinase kinase 7 [OS=Homo sapiens]",5,4,5,4,606,67.2,7.11,2.45,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","signal transduction activity or receptor binding;kinase activity;other molecular function","MAP3K7","ENSG00000135341","IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL-6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway","Downstream TCR signaling; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway","MAPK signaling pathway; NF-kappa B signaling pathway; Autophagy; AMPK signaling pathway; Wnt signaling pathway; Osteoclast differentiation; Adherens junction; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; T cell receptor signaling pathway; TNF signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Leishmaniasis; Toxoplasmosis; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",360.4,337,374.1,348.8,298.1,347.2,1.0778593702846795,0.10816896006842795,0.26361859670100823,0.579023956142707,0.46233917408838104,0.3350393071467422,4452]
["Low","O43323","desert hedgehog protein [OS=Homo sapiens]",2,1,1,1,396,43.6,9.28,0,"cell-cell signaling;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","DHH","ENSG00000139549","Hedgehog signaling pathway; Hedgehog signaling pathway; Somatic sex determination; Mammalian disorder of sexual development","Release of Hh-Np from the secreting cell; Activation of SMO; Class B/2 (Secretin family receptors); Ligand-receptor interactions; HHAT G278V doesn't palmitoylate Hh-Np; Transcriptional regulation of testis differentiation","Hedgehog signaling pathway",26.1,22.9,27.9,51.5,36.8,40.4,0.5975135975135976,-0.7429565502588752,0.02072707576875359,1.6834619650106168,0.0977276615956691,1.0099824928008427,1656]
["High","O43324-1","Eukaryotic translation elongation factor 1 epsilon-1 [OS=Homo sapiens]",43,6,18,6,174,19.8,8.54,38.05,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EEF1E1","ENSANAG00000036153; ENSG00000124802; ENSPTRG00000017709","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","",762.7,802,733.6,853.7,813.5,818.1,0.9247575745382851,-0.11285288261020088,0.057102824185363554,1.2433424119329959,0.18280395704769112,0.738014407588091,2439]
["High","O43347","RNA-binding protein Musashi homolog 1 [OS=Homo sapiens]",25,7,21,6,362,39.1,7.85,39.55,"developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MSI1","ENSG00000135097","","Regulation of expression of SLITs and ROBOs","mRNA surveillance pathway",877.6,904.2,869.2,971.5,1065.2,1009.4,0.8702931617478086,-0.20042663443551648,0.010720129279815648,1.9697999772204866,0.06810640310561479,1.1668120554483052,1229]
["Medium","O43353-1","Receptor-interacting serine/threonine-protein kinase 2 [OS=Homo sapiens]",1,1,1,1,540,61.2,7.09,2.02,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","RIPK2","ENSG00000104312","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor (TCR) signaling pathway","Downstream TCR signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases","NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Shigellosis; Salmonella infection; Tuberculosis",36.9,39.5,36.5,48.8,48.9,40.7,0.8157514450867053,-0.2937984568637237,0.041697696925014294,1.3798879316060844,0.15052039648197485,0.8224046463865403,2163]
["High","O43379-1","Wd repeat-containing protein 62 [OS=Homo sapiens]",4,5,6,1,1518,165.8,5.91,8.62,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;nucleus","","WDR62","ENSG00000075702","","","",164.9,164.7,193.8,185.9,166.1,167,1.0084778420038538,0.012179385802791995,0.9056809052334006,0.0430247885332541,0.9508614371470205,0.021882765362102586,7437]
["High","O43390-1","heterogeneous nuclear ribonucleoprotein r [OS=Homo sapiens]",58,28,215,20,633,70.9,8.13,525.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","Hnrnpr; HNRNPR; LOC111154612","ENSAMEG00000009537; ENSCAFG00000013308; ENSCANG00000026442; ENSCATG00000035305; ENSFCAG00000019123; ENSG00000125944; ENSG00000282958; ENSGGOG00000013250; ENSLCNG00005013650; ENSMFAG00000039737; ENSMMUG00000010970; ENSMPUG00000015898; ENSNLEG00000008411; ENSRROG00000036942; ENSSSUG00005005658; ENSUAMG00000027050; ENSUMAG00000013292","mRNA Processing; mRNA processing","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","",4560.6,4472.1,4531.1,4761.6,4992.2,4991.2,0.9198914886402172,-0.12046440549337016,0.00827129226111807,2.082426633370142,0.05855145056646408,1.232462341151697,1103]
["High","O43395","U4/U6 small nuclear ribonucleoprotein Prp3 [OS=Homo sapiens]",42,25,86,25,683,77.5,9.5,169.89,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","PRPF3","ENSG00000117360","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",3620.1,3373.8,3712.2,3873.6,3555.1,3684.2,0.963393893583133,-0.05380231537315451,0.37818362144757545,0.4222972837114084,0.579559905056461,0.23690166739521823,5095]
["High","O43396","Thioredoxin-like protein 1 [OS=Homo sapiens]",52,12,49,12,289,32.2,4.96,135.55,"","cytosol;nucleus;other cell component","other molecular function","TXNL1","ENSG00000091164","","RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle","",1908.9,1917.9,2025.9,2071.4,1957.1,2049.9,0.962868518031061,-0.05458928678245274,0.21719033087199405,0.6631595130721866,0.4118072130763792,0.38530605069556373,4118]
["High","O43399","Tumor protein D54 [OS=Homo sapiens]",60,9,25,9,206,22.2,5.36,49.43,"other metabolic processes;other biological processes","other cell component","other molecular function","TPD52L2","ENSG00000101150","","","",959.7,952.2,947.3,993.1,939.7,867.2,1.0211428571428571,0.03018471232179939,0.6189496874446405,0.20834465203516192,0.7752260442040028,0.11057164531734756,6234]
["High","O43402","ER membrane protein complex subunit 8 [OS=Homo sapiens]",42,7,21,7,210,23.8,6.4,44.2,"cell organization and biogenesis","other membranes;cytosol;ER/Golgi;other cell component","","EMC8","ENSG00000131148","","","",606,616.3,578.5,585.8,572.6,592.9,1.0282647176383257,0.040211721400045655,0.2654099251802305,0.5760828404376387,0.46464589592090577,0.33287789449114513,4460]
["High","O43414-1","ERI1 exoribonuclease 3 [OS=Homo sapiens]",3,1,4,1,337,37.2,8.07,8.71,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","ERI3","ENSG00000117419; ENSMFAG00000044436; ENSMLEG00000012810; ENSMMUG00000011651; ENSMNEG00000035539; ENSNLEG00000014004; ENSPANG00000013867; ENSPPAG00000042776; ENSPTRG00000000655; ENSRBIG00000044795; ENSRROG00000036414","","","",239,220,257.9,266.2,249,263.1,0.9211101117820891,-0.118554464926384,0.16747334930293986,0.7760542941289355,0.3521766526682883,0.45323943869645894,3713]
["High","O43422-1","52 kDa repressor of the inhibitor of the protein kinase [OS=Homo sapiens]",10,4,6,4,761,87.6,5.86,13.15,"other metabolic processes;signal transduction;other biological processes","","nucleic acid binding activity;kinase activity;other molecular function","THAP12","ENSG00000137492; ENSPTRG00000004091","","","",89.7,100.4,86.9,73.1,74.9,76.1,{"$f":"AVERAGE(T386:V386)/AVERAGE(W386:Y386)","v":1.2360553324408745},{"$f":"LOG(Z386,2)","v":0.3057433274261573},{"$f":"TTEST(T386:V386,W386:Y386,2,2)","v":0.013767327552174581},{"$f":"-LOG10(AB386)","v":1.8611503547310484},{"$f":"AB386*7808/AF386","v":0.07733474354487707},{"$f":"-LOG10(AD386)","v":1.111625350326508},1390]
["High","O43426","Synaptojanin-1 [OS=Homo sapiens]",6,7,8,7,1573,173,7.42,17.28,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ1","ENSG00000159082","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway","Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Clathrin-mediated endocytosis; Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",249.6,219.9,255.8,187.9,200.1,207.7,1.217559174080913,0.2839918898259168,0.02584649577302024,1.5875983295372382,0.11312188284514688,0.946453374918707,1784]
["High","O43427","Acidic fibroblast growth factor intracellular-binding protein [OS=Homo sapiens]",23,8,15,8,364,41.9,6.48,25.79,"signal transduction","other membranes;mitochondrion;nucleus;other cell component","other molecular function","FIBP","ENSG00000172500","Modulators of TCR signaling and T cell activation","","",773.6,821.6,756.6,770.4,804.5,753.4,1.010093201047975,0.014488416230734706,0.7659708358042071,0.11578776573348465,0.8702998087833599,0.06033111189803513,6872]
["High","O43432","Eukaryotic translation initiation factor 4 gamma 3 [OS=Homo sapiens]",23,32,66,25,1585,176.5,5.38,113.78,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","nucleic acid binding activity","EIF4G3","ENSG00000075151","Translation factors; Translation inhibitors in chronically activated PDGFRA cells","ISG15 antiviral mechanism","Viral myocarditis",1571.6,1457.2,1623.8,1667.7,1591.8,1654.6,0.9467857796951629,-0.07889005729533219,0.18491561471298262,0.7330264144365071,0.37424082936209646,0.42684883308573746,3858]
["High","O43439","Protein CBFA2T2 [OS=Homo sapiens]",3,2,4,2,604,67.1,8.05,10.01,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","other molecular function","CBFA2T2","ENSG00000078699","","","",216.3,209.8,245.9,241.9,222.5,215.1,0.9889624724061811,-0.0160123179886309,0.8639320752764288,0.06352040160937159,0.9273551888587237,0.03275389366942928,7274]
["High","O43447","peptidyl-prolyl cis-trans isomerase H [OS=Homo sapiens]",52,9,51,8,177,19.2,8.07,58.75,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PPIH","ENSG00000171960","","mRNA Splicing - Major Pathway","Spliceosome",1779.9,1846.2,1769.6,1774.6,1707.3,1749.7,1.031367076993654,0.044557898084240447,0.15257831627041282,0.8165071819331325,0.3339869619959023,0.4762704866128511,3567]
["Medium","O43462","Membrane-bound transcription factor site-2 protease [OS=Homo sapiens]",2,1,1,1,519,57.4,7.49,2.45,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MBTPS2","ENSG00000012174","Sterol regulatory element-binding proteins (SREBP) signaling; Type I collagen synthesis in the context of osteogenesis imperfecta; Unfolded protein response","Regulation of cholesterol biosynthesis by SREBP (SREBF); ATF6 (ATF6-alpha) activates chaperones; CREB3 factors activate genes; Assembly of active LPL and LIPC lipase complexes","Protein processing in endoplasmic reticulum",32.9,30.7,34,35.7,37.9,41.9,0.845021645021645,-0.24293979874053365,0.044136988310799534,1.355197304265082,0.15565564802652337,0.8078351161491507,2214]
["High","O43463","Histone-lysine N-methyltransferase SUV39H1 [OS=Homo sapiens]",3,1,2,1,412,47.9,8.03,7.6,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SUV39H1","ENSG00000101945","Histone modifications; Retinoblastoma gene in cancer; Interactions between LOXL4 and oxidative stress pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","PKMTs methylate histone lysines; SIRT1 negatively regulates rRNA expression","Lysine degradation; Metabolic pathways",101.3,81.3,101.6,93,117.7,107.9,0.8920276208411801,-0.1648397122825295,0.30833841778602916,0.5109723604729223,0.5086639269117507,0.2935690602822808,4733]
["High","O43464","Serine protease HTRA2, mitochondrial [OS=Homo sapiens]",22,6,12,6,458,48.8,10.07,17.97,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HTRA2","ENSG00000115317","Apoptosis modulation and signaling; Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity","","Apoptosis; Apoptosis; Parkinson disease; Pathways of neurodegeneration",38.9,39.5,33.4,35.2,37.2,31.8,1.0729366602687143,0.10156491056468221,0.3682910259848955,0.4338088633137617,0.5705587958115207,0.24369959510065153,5040]
["High","O43482","Protein Mis18-beta [OS=Homo sapiens]",10,2,2,2,229,24.7,7.37,2.03,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","other molecular function","OIP5","ENSG00000104147","","Deposition of new CENPA-containing nucleosomes at the centromere","",64.8,75.4,67,100.2,88.1,100.1,0.7184466019417476,-0.4770471615542686,0.006291189015722669,2.2012672664519064,0.04992032910036849,1.3017225602246127,984]
["High","O43488","aflatoxin B1 aldehyde reductase member 2 [OS=Homo sapiens]",18,6,11,6,359,39.6,7.17,9.95,"other metabolic processes","cytosol;ER/Golgi","other molecular function","AKR7A2","ENSG00000053371","Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II","Aflatoxin activation and detoxification","Metabolism of xenobiotics by cytochrome P450",467.9,484.2,479.9,448.9,478.2,440.2,1.0473195348497037,0.06670167246183649,0.15919945844250902,0.798058413959091,0.34271556975988704,0.46506616488089,3627]
["High","O43490-1","Prominin-1 [OS=Homo sapiens]",6,4,4,4,865,97.1,7.27,8.05,"developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","PROM1","ENSG00000007062","Extracellular vesicle-mediated signaling in recipient cells","","Transcriptional misregulation in cancer",47.9,45.8,49.3,55.4,57.4,54,0.857314148681055,-0.22210414177891205,4.9958966815491284E-3,2.3013865517024388,0.04397740844367034,1.35677036687553,887]
["High","O43491-1","band 4.1-like protein 2 [OS=Homo sapiens]",54,50,238,7,1005,112.5,5.44,509.23,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","EPB41L2","ENSG00000079819","Splicing factor NOVA regulated synaptic proteins","Neurexins and neuroligins","",8858.3,8983.3,8905.7,10077.3,9320.1,9736.8,0.9180722312608549,-0.12332042972066917,0.023074468489358214,1.636868293976908,0.104747354630761,0.9798569362258216,1720]
["High","O43491-4","Isoform 4 of Band 4.1-like protein 2 [OS=Homo sapiens]",54,44,189,1,852,95.5,5.77,395.37,"","","","EPB41L2","","","","",9.2,16.8,12.5,26.8,18.9,20.7,0.5798192771084337,-0.7863247957646611,0.045814701274282034,1.3389951408211964,0.159768283854218,0.7965094297415913,2239]
["High","O43493-1","Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",26,11,21,11,480,51.1,5.73,42.75,"","","","","","","","",1046.7,973.7,1004.8,1079.1,988.1,1048.1,0.9710782268160371,-0.04234057587139109,0.4278232285115407,0.36873563925837255,0.6241486861394077,0.20471193935950383,5352]
["High","O43502","DNA repair protein RAD51 homolog 3 [OS=Homo sapiens]",5,2,2,2,376,42.2,6.74,5.99,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD51C","ENSG00000108384","DNA repair pathways, full network","Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination","Homologous recombination; Fanconi anemia pathway",43.7,37.4,38.4,48.2,49.7,47.2,0.8235699517574087,-0.28003690119863356,0.014951314022851608,1.825320636918447,0.08135181873897238,1.0896327333298228,1435]
["High","O43504","Ragulator complex protein LAMTOR5 [OS=Homo sapiens]",11,1,3,1,91,9.6,4.87,9.14,"cell organization and biogenesis;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","LAMTOR5","ENSG00000134248","","Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","mTOR signaling pathway",76.7,79.3,76.1,106.1,69.6,79.5,0.9094827586206896,-0.13688180642038705,0.5204265699135973,0.28364053902764197,0.7018118580112898,0.15377929809644275,5790]
["High","O43505","beta-1,4-glucuronyltransferase 1 [OS=Homo sapiens]",11,4,6,4,415,47.1,7.2,12.9,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B4GAT1","ENSG00000174684","","Keratan sulfate biosynthesis; Defective LARGE causes MDDGA6 and MDDGB6; O-linked glycosylation","Mannose type O-glycan biosynthesis; Metabolic pathways",352.5,312.7,333.1,494.9,464.1,520.2,0.6748918334234723,-0.5672717984842617,1.2842699256233941E-3,2.8913436874131193,0.023989424830783403,1.6199801645295189,418]
["High","O43524","Forkhead box protein O3 [OS=Homo sapiens]",2,1,1,1,673,71.2,5.16,2.2,"RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXO3","ENSG00000118689","IL-5 signaling pathway; Energy metabolism; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Kit receptor signaling pathway; Copper homeostasis; NAD metabolism, sirtuins and aging; Imatinib and chronic myeloid leukemia; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Non-small cell lung cancer; Leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; DNA damage response (only ATM dependent)","MAPK6/MAPK4 signaling; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by NODAL; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; FoxO signaling pathway; Mitophagy; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Neurotrophin signaling pathway; Prolactin signaling pathway; Alcoholic liver disease; Shigellosis; Chemical carcinogenesis; Endometrial cancer; Non-small cell lung cancer",28.4,25.5,24.3,32.5,23.2,27.1,0.9444444444444443,-0.08246216019197317,0.6315810263551374,0.19957092532783052,0.7852523334046039,0.10499076440639127,6280]
["Medium","O43529","Carbohydrate sulfotransferase 10 [OS=Homo sapiens]",2,1,1,1,356,42.2,8.03,2.54,"cell adhesion;protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST10","ENSG00000115526","Metapathway biotransformation Phase I and II","Reactions specific to the complex N-glycan synthesis pathway","Mannose type O-glycan biosynthesis; Metabolic pathways",72.3,58,53.1,57.8,76.4,63.4,0.9281376518218625,-0.10758930798962307,0.5845541725863872,0.2331752351177979,0.7487203050450314,0.12568038879070656,6096]
["High","O43542","DNA repair protein XRCC3 [OS=Homo sapiens]",6,2,2,2,346,37.8,8.48,5,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","XRCC3","ENSG00000126215","Fluoropyrimidine activity; Male infertility","Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange","Homologous recombination",79.6,71.5,80.3,90.5,82.5,89,0.8832061068702289,-0.17917794731732284,0.052667989474988214,1.2784532598954894,0.17417690038996525,0.7590094423155811,2361]
["High","O43567","E3 ubiquitin-protein ligase RNF13 [OS=Homo sapiens]",6,1,2,1,381,42.8,4.98,2.91,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RNF13","ENSG00000082996","","","",58,46.4,64.3,49.5,59,74.2,0.9233716475095785,-0.11501666033992301,0.6277830708633048,0.20219039989717635,0.7823990769833493,0.10657167056870977,6265]
["High","O43572","A-kinase anchor protein 10, mitochondrial [OS=Homo sapiens]",7,3,5,3,662,73.8,6.39,5.68,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","AKAP10","ENSG00000108599","G protein signaling pathways","Factors involved in megakaryocyte development and platelet production","",39.9,40.8,31.9,42.5,38.6,40.2,0.9282769991755977,-0.1073727230402807,0.395070218302546,0.40332570763659614,0.5946998774833775,0.22570215097154578,5187]
["High","O43583","density-regulated protein [OS=Homo sapiens]",22,5,19,5,198,22.1,5.3,47.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","","nucleic acid binding activity","DENR","ENSG00000139726","","","",841,786,801.3,1191.7,808.9,788.1,0.8707641553411986,-0.19964607410429658,0.41497283325942746,0.3819803340149224,0.6131922562622274,0.21240333829877656,5284]
["High","O43592","Exportin-T [OS=Homo sapiens]",26,19,39,19,962,109.9,5.39,77.6,"transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPOT","ENSG00000184575","","tRNA processing in the nucleus","Nucleocytoplasmic transport",1385.4,1362.2,1353.6,1335.5,1581.2,1433.6,0.9427395811783099,-0.08506879358347641,0.31323561218906915,0.5041288682680457,0.5142438309445442,0.2888309095560643,4756]
["Medium","O43593-1","lysine-specific demethylase hairless [OS=Homo sapiens]",2,1,1,1,1189,127.4,7.08,0,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HR","ENSG00000168453","","","",32.9,27.1,31.6,35.2,37.2,39.2,0.8207885304659497,-0.2849175237322439,0.033837971078601974,1.4705956851065267,0.13197146762323886,0.8795199535911911,2002]
["High","O43597","Protein sprouty homolog 2 [OS=Homo sapiens]",6,2,3,2,315,34.7,8.35,9.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","SPRY2","ENSG00000136158","Glioblastoma signaling pathways; Ectoderm differentiation; EGF/EGFR signaling pathway","EGFR downregulation; Spry regulation of FGF signaling","MicroRNAs in cancer",119.2,123.6,128.1,249.2,229.2,249,0.5098982678031344,-0.9717186579526073,7.5247053085962431E-5,4.123510503754929,0.00851491290572746,2.069819789833548,69]
["High","O43598-1","2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [OS=Homo sapiens]",32,5,17,5,174,19.1,5.05,19.41,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","C6orf108; DNPH1","ENSG00000112667","","Purine catabolism","",766.1,813.8,772.2,825.4,796.7,732.7,0.9988534058094106,-1.6551348180937678E-3,0.9783901568868021,0.009487925177872683,0.9889023100287573,0.004846608616109574,7725]
["High","O43602","Neuronal migration protein doublecortin [OS=Homo sapiens]",10,2,2,2,365,40.5,9.28,2.77,"cell organization and biogenesis;developmental processes;signal transduction","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DCX","ENSG00000077279","","Neurofascin interactions","",115,122.5,103.9,117,118.4,104.7,1.0038224051749485,0.005504052319896081,0.9531922628913609,0.02081949150101706,0.9768375362456683,0.010177660415392911,7619]
["High","O43615","Mitochondrial import inner membrane translocase subunit TIM44 [OS=Homo sapiens]",52,24,96,24,452,51.3,8.32,201.09,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus","other molecular function","TIMM44","ENSG00000104980","","Mitochondrial protein import","",3654.4,3548.7,3805,3735.9,3845,3829.1,0.9647765118317265,-0.05173331065555959,0.17673722286238513,0.7526719735193996,0.36449134604054495,0.43831277848854217,3786]
["High","O43617-1","Trafficking protein particle complex subunit 3 [OS=Homo sapiens]",42,9,25,9,180,20.3,4.96,40.56,"transport","other membranes;cytosol;ER/Golgi;other cell component","","TRAPPC3","ENSCANG00000028241; ENSCATG00000041647; ENSCSAG00000001096; ENSG00000054116; ENSGGOG00000004752; ENSMMUG00000022499; ENSMNEG00000014589; ENSPPAG00000041117; ENSPPYG00000001546; ENSRBIG00000043692; ENSRROG00000034420","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",1599.9,1769.1,1631.3,1695.5,1830.3,1640.2,0.9679248935346496,-0.047032989462844677,0.511431943151486,0.2912121501830066,0.6941179579570316,0.15856671954987048,5753]
["High","O43633","charged multivesicular body protein 2a [OS=Homo sapiens]",14,3,5,3,222,25.1,5.97,7.85,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","CHMP2A","ENSG00000130724","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Endocytosis; Necroptosis",207.6,213.6,241.7,233.3,197.3,196.6,1.0569196428571428,0.0798656934107808,0.499380464678219,0.30156845086812,0.6849047370819487,0.16436983002103225,5693]
["High","O43639","Cytoplasmic protein NCK2 [OS=Homo sapiens]",23,8,13,7,380,42.9,6.95,29.84,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NCK2","ENSG00000071051","Pathogenic Escherichia coli infection; Brain-derived neurotrophic factor (BDNF) signaling pathway; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; ErbB signaling pathway","RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Ephrin signaling; Activation of RAC1; Regulation of cortical dendrite branching","ErbB signaling pathway; Axon guidance; T cell receptor signaling pathway; Pathogenic Escherichia coli infection",413,415.8,430.2,453.9,401.6,426.9,0.9817529631940112,-0.026568047548169254,0.651670523844996,0.1859719224307846,0.7974053361826875,0.0983208623945406,6381]
["High","O43657","Tetraspanin-6 [OS=Homo sapiens]",20,6,20,6,245,27.5,8.1,46.7,"other biological processes","plasma membrane;other membranes","","TSPAN6","ENSG00000000003","","","",630.2,667.4,816.1,580.6,513.2,596.7,1.2503401360544215,0.32232061156530745,0.08621454789404798,1.0644194448827011,0.23357501386423546,0.6315736167020364,2882]
["High","O43660-1","Pleiotropic regulator 1 [OS=Homo sapiens]",37,13,32,13,514,57.2,9.17,67.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","","PLRG1","ENSG00000171566","","mRNA Splicing - Major Pathway","Spliceosome",1174.8,1181.5,1144.9,1135.3,1258.5,1225.6,0.9673426534784773,-0.047901081183069454,0.36408383980784165,0.4387985971935898,0.5656121411101528,0.24748127679151155,5026]
["High","O43663-1","Protein regulator of cytokinesis 1 [OS=Homo sapiens]",24,12,21,12,620,71.6,6.68,31.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","PRC1","ENSG00000198901","","RHO GTPases activate CIT","",517.9,518,511.8,534.7,603.1,591.2,0.8951417004048582,-0.15981201665581432,0.04635111772981754,1.3339397886383813,0.16049202981570526,0.7945465301937252,2255]
["High","O43670-1","BUB3-interacting and GLEBS motif-containing protein ZNF207 [OS=Homo sapiens]",16,8,37,8,478,50.7,9.1,88.14,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","LOC111151255; Znf207; ZNF207","ENSAMEG00000005671; ENSANAG00000033773; ENSCANG00000036057; ENSCJAG00000014376; ENSECAG00000017464; ENSG00000010244; ENSGGOG00000024003; ENSMFAG00000001904; ENSMLEG00000018149; ENSMMUG00000016875; ENSMNEG00000041308; ENSNLEG00000005954; ENSOCUG00000008195; ENSPCOG00000020744; ENSPPAG00000032098; ENSPTRG00000008989; ENSRROG00000037743; ENSSBOG00000026038; ENSSTOG00000000712","","","",1199.3,1130,1200.4,1204.6,1095.8,1188.3,1.011752228623843,0.01685602688826092,0.7562427689800506,0.12133876494387319,0.8652906711893662,0.06283797844470441,6824]
["High","O43674-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [OS=Homo sapiens]",21,4,13,4,189,21.7,9.63,29.64,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB5","ENSG00000136521; ENSGGOG00000005222; ENSPTRG00000015649","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",700.3,787.5,706.3,731.5,768.9,754.3,0.9731228101299508,-0.03930620726546538,0.5395916024367536,0.2679348177913826,0.7157885205277221,0.14521527089633934,5886]
["High","O43676","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [OS=Homo sapiens]",11,1,3,1,98,11.4,9.2,6.82,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB3","ENSG00000119013","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",138.5,166.1,143.4,162,139.2,155,0.9820254274441036,-0.026167714367170726,0.8135400070442513,0.08962108512253507,0.8993516034265205,0.04607048671506701,7063]
["High","O43678","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [OS=Homo sapiens]",37,3,4,3,99,10.9,9.57,6.95,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;mitochondrion","transporter activity","NDUFA2","ENSG00000131495","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",139.3,138,123.1,230.4,135.1,159.3,0.7629573170731708,-0.39032574578209,0.22686912487036842,0.6442246042067751,0.42276709474650037,0.37389882251443496,4190]
["High","O43681","ATPase ASNA1 [OS=Homo sapiens]",44,10,49,10,348,38.8,4.91,98.01,"cell organization and biogenesis;transport","ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","GET3","ENSG00000198356","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",1552.7,1570.2,1550.1,1451.1,1552,1506.5,1.0362338123115131,0.051349564610950145,0.14209179512391076,0.8474309990274064,0.3179858802887633,0.49759216381688187,3489]
["High","O43683","Mitotic checkpoint serine/threonine-protein kinase BUB1 [OS=Homo sapiens]",18,14,36,14,1085,122.3,6.47,103.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","BUB1","ENSG00000169679","Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation",1317.3,1394.2,1326.9,903.3,942.2,936.9,1.4514088556641749,0.5374539776759619,1.0223713535247423E-4,3.990391327789377,0.009071222191274077,2.0423341952809104,88]
["High","O43684","Mitotic checkpoint protein BUB3 [OS=Homo sapiens]",55,13,61,13,328,37.1,6.84,138.72,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","BUB3","ENSG00000154473","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Human T-cell leukemia virus 1 infection",2169.4,2222,2117.2,2190.7,2426.3,2438,0.9225513819985827,-0.11629882979542039,0.10172497842265754,0.9925723935948222,0.2584668504796974,0.587595149192565,3073]
["High","O43687-1","A-kinase anchor protein 7 isoforms alpha and beta [OS=Homo sapiens]",12,1,1,1,104,11.5,4.94,2.61,"transport;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","AKAP7","ENSG00000118507; ENSGGOG00000008778; ENSPPAG00000039914; ENSPTRG00000018599","G protein signaling pathways","","",64.8,49.3,72.9,59.4,64.4,51.7,1.0655270655270657,0.09156723958307615,0.6507669336030175,0.18657452229722532,0.7964244855129091,0.09885539635975228,6380]
["High","O43688","Phospholipid phosphatase 2 [OS=Homo sapiens]",7,2,6,2,288,32.6,8.35,5.2,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","PLPP2","ENSG00000141934","Triacylglyceride synthesis","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",355.2,387.3,355.7,377.2,370.8,404.1,0.9532158666782398,-0.06912512889474544,0.2894139072142096,0.5384806035512191,0.4902893876173896,0.30954750701710404,4609]
["High","O43707","Alpha-actinin-4 [OS=Homo sapiens]",70,61,472,40,911,104.8,5.44,1101.64,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","ACTN4","ENSG00000130402; ENSG00000282844","Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome","Platelet degranulation ; Nephrin family interactions","Focal adhesion; Adherens junction; Tight junction; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Amoebiasis; Viral carcinogenesis; Systemic lupus erythematosus",19645.3,19294.8,19742.3,19050.5,18446.7,18438.8,1.0490989702517162,0.06915078578566411,0.01990436926866548,1.701051579822066,0.09587496313987666,1.0182947900119457,1621]
["Low","O43708","maleylacetoacetate isomerase [OS=Homo sapiens]",5,1,1,1,216,24.2,8.54,0,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","GSTZ1","ENSG00000100577","Metapathway biotransformation Phase I and II","Regulation of pyruvate dehydrogenase (PDH) complex; Glutathione conjugation; Tyrosine catabolism","Tyrosine metabolism; Metabolic pathways",24.2,16.7,16.1,18,15.7,13.5,1.2076271186440677,0.2721750596902626,0.32468863026668066,0.4885329189468191,0.5260777806852548,0.2789500405893921,4819]
["High","O43709-1","Probable 18S rRNA (guanine-N(7))-methyltransferase [OS=Homo sapiens]",16,5,9,5,281,31.9,8.73,28.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","BUD23","ENSG00000071462; ENSGGOG00000001453","7q11.23 copy number variation syndrome","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",466.1,497.7,481.9,503.9,510.6,470.3,0.9736664870689653,-0.03850040866642706,0.4463548955886886,0.3503196975530673,0.6401798355540927,0.19369800942572898,5444]
["High","O43719","HIV Tat-specific factor 1 [OS=Homo sapiens]",50,32,81,32,755,85.8,4.4,178.62,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","HTATSF1","ENSG00000102241","","","",3357.7,3253.3,3452.4,3608.1,3296.5,3527.1,0.9646941533978162,-0.05185647200378964,0.32548624458383146,0.4874673604830962,0.5267143207690271,0.2784248735042722,4825]
["High","O43739","cytohesin-3 [OS=Homo sapiens]",17,4,10,2,400,46.3,5.47,24.52,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","CYTH3","ENSG00000008256","Insulin signaling","Intra-Golgi traffic","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection",209.5,202.9,194,186.2,185.7,192,1.075367973044866,0.1048304105577203,0.04517262484390815,1.345124673173278,0.15823591511046875,0.8006949369948803,2229]
["High","O43741","5'-AMP-activated protein kinase subunit beta-2 [OS=Homo sapiens]",22,4,6,4,272,30.3,6.46,9.93,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PRKAB2","ENSG00000131791","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Caloric restriction and aging; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Carnitine metabolism; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy",361.6,321.8,376.6,380.5,382.8,400.6,0.9107311624710025,-0.1349028452604825,0.11955911418645937,0.9224173113088846,0.28521770961438275,0.5448235119582535,3273]
["High","O43747-1","AP-1 complex subunit gamma-1 [OS=Homo sapiens]",23,16,55,16,822,91.3,6.8,113.33,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","AP1G1","ENSCANG00000031796; ENSCCAG00000037984; ENSCJAG00000015028; ENSG00000166747; ENSGGOG00000004800; ENSMFAG00000037769; ENSMLEG00000040277; ENSMMUG00000010878; ENSMNEG00000034875; ENSPANG00000016832; ENSPPAG00000031149; ENSPTRG00000008327; ENSRBIG00000018408; ENSRROG00000025423; ENSSBOG00000025975","","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","Lysosome; Human immunodeficiency virus 1 infection",2278.2,2513,2228.6,2055.6,2407.8,2208.9,1.0520809915621299,0.0732457708159419,0.4376563085173033,0.3588668070925084,0.6335225170380245,0.19823794455074537,5394]
["High","O43752","Syntaxin-6 [OS=Homo sapiens]",31,4,20,4,255,29.2,4.93,32.58,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STX6","ENSG00000135823","","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","SNARE interactions in vesicular transport",197.1,208.6,249.1,203.3,192.4,178.3,1.1407665505226479,0.19000358491110303,0.19555427397542072,0.7087326877984934,0.3874366331388188,0.41179931800546105,3941]
["High","O43760","Synaptogyrin-2 [OS=Homo sapiens]",32,3,6,3,224,24.8,4.94,14.02,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","SYNGR2","ENSG00000108639","","","",182.2,196.7,170.4,183.6,176.8,173.7,1.0284590900580417,0.04048440762635891,0.5677452179094611,0.24584651513425895,0.7368608147335558,0.13261453805920942,6016]
["High","O43765","Small glutamine-rich tetratricopeptide repeat-containing protein alpha [OS=Homo sapiens]",38,11,72,11,313,34,4.87,137.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","SGTA","ENSG00000104969","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",3805.6,3784.5,3791.1,3594,3650.2,3444.9,1.064748201438849,0.09051229290544241,0.0200002507644934,1.6989645590883686,0.09580488218967145,1.018612358833691,1630]
["High","O43766-1","Lipoyl synthase, mitochondrial [OS=Homo sapiens]",2,1,1,1,372,41.9,8.59,2.72,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","LIAS","ENSG00000121897","","Glyoxylate metabolism and glycine degradation","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors",65.5,77.3,79.1,87.9,85.8,79,0.8781163434903048,-0.18751599674776365,0.11133806732229345,0.953356321726298,0.27294431072290964,0.5639259537390319,3185]
["Medium","O43768","alpha-endosulfine [OS=Homo sapiens]",12,2,2,2,121,13.4,7.24,2.11,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ENSA","ENSG00000143420","","MASTL Facilitates Mitotic Progression","",140.3,159.7,146,202.2,114.5,107.3,1.0518867924528301,0.07297944535710546,0.8248548273844716,0.08362247958782824,0.9062145057292746,0.04276899037162031,7107]
["High","O43776","Asparagine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",42,23,123,23,548,62.9,6.25,267.5,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","NARS1","ENSG00000134440","Photodynamic therapy-induced unfolded protein response","Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",5151.9,5076.7,5180.9,5124,5367,5246.1,0.9791829498446345,-0.030349657760341812,0.2276893022696725,0.6426573737519683,0.4234869157030974,0.3731600033397145,4198]
["High","O43791","Speckle-type POZ protein [OS=Homo sapiens]",7,2,2,2,374,42.1,5.8,2.04,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SPOP","ENSG00000121067","mRNA processing; Hedgehog signaling pathway","Hedgehog 'on' state","Hedgehog signaling pathway",17.6,24.5,19.5,27.7,27,17.9,0.8484848484848486,-0.2370391973008491,0.38560195789178087,0.4138607696358098,0.586096960720075,0.23203053070151158,5137]
["High","O43795","Unconventional myosin-Ib [OS=Homo sapiens]",20,21,52,21,1136,131.9,9.38,118.64,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1B","ENSG00000128641","","","Pathogenic Escherichia coli infection",2518.9,2542.7,2452.6,2328.3,2467.2,2427.8,1.040272451649523,0.05696142564187535,0.12084083489695922,0.917786282820391,0.28766013380349315,0.5411203218734347,3280]
["High","O43808","peroxisomal membrane protein PMP34 [OS=Homo sapiens]",3,1,2,1,307,34.5,10.08,5.73,"other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","SLC25A17","ENSG00000100372","","Class I peroxisomal membrane protein import; Alpha-oxidation of phytanate","Peroxisome",108.9,96,72.4,89.1,97.2,97.9,0.9757213230119632,-0.035458938203301954,0.845330020765554,0.07297370736256152,0.9187551227919607,0.03680022636317405,7184]
["High","O43809","Cleavage and polyadenylation specificity factor subunit 5 [OS=Homo sapiens]",65,13,76,13,227,26.2,8.82,166.08,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT21","ENSG00000167005","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",3934.9,4064,4027.4,3657.9,4132.9,3847,1.0333825980855489,0.047374494442407246,0.41729215622537685,0.37955977857621764,0.6148739678821934,0.21121389343191177,5299]
["High","O43813","LanC-like protein 1 [OS=Homo sapiens]",22,7,17,7,399,45.3,7.75,32.8,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LANCL1","ENSG00000115365","","","Glutathione metabolism; Metabolic pathways",690,703.7,708.2,678.4,721.1,760.4,0.9731469049493031,-0.039270486135836634,0.47084467044482037,0.3271223410550549,0.6612149616606399,0.17965732797847692,5560]
["High","O43815","striatin [OS=Homo sapiens]",33,19,37,19,780,86.1,5.27,61.18,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STRN","ENSG00000115808","","PIP3 activates AKT signaling; Extra-nuclear estrogen signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins","",1474.8,1459.4,1520.3,1679.3,1549.4,1603.6,0.9218177679365934,-0.11744651915577617,0.03964402647024802,1.401822242556977,0.1462166077844575,0.8350032959177537,2117]
["High","O43818","U3 small nucleolar RNA-interacting protein 2 [OS=Homo sapiens]",28,11,31,11,475,51.8,7.85,70.76,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RRP9","ENSG00000114767","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1661.5,1772,1606.5,1594.1,1833.6,1732.1,{"$f":"AVERAGE(T450:V450)/AVERAGE(W450:Y450)","v":0.9767820458157294},{"$f":"LOG(Z450,2)","v":-0.03389141242718183},{"$f":"TTEST(T450:V450,W450:Y450,2,2)","v":0.662109125003066},{"$f":"-LOG10(AB450)","v":0.1790704267521658},{"$f":"AB450*7808/AF450","v":0.8051312954405762},{"$f":"-LOG10(AD450)","v":0.09413329201002497},6421]
["High","O43819","Protein SCO2 homolog, mitochondrial [OS=Homo sapiens]",30,5,9,5,266,29.8,8.85,18.75,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO2","ENSG00000284194","","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Central carbon metabolism in cancer",174.6,184.9,166.7,156.1,173.1,160.3,1.0749744637385088,0.10430238867483203,0.17098790548740356,0.7670346075367545,0.356971541723435,0.4473664050785993,3740]
["High","O43822","Protein C21orf2 [OS=Homo sapiens]",7,2,2,2,256,28.3,7.34,2.19,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","","CFAP410","ENSG00000160226","Ciliopathies","","",69,39.3,57.9,58.4,55.4,41.4,1.070876288659794,0.0987918245832171,0.7355675983118316,0.13337740964644484,0.8530093283259738,0.06904621945575484,6733]
["High","O43823","A-kinase anchor protein 8 [OS=Homo sapiens]",39,16,37,16,692,76.1,5.15,103.33,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","mitochondrion;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","AKAP8","ENSG00000105127","G protein signaling pathways","","",1387.2,1238.5,1330.7,1584.8,1430.7,1430.2,0.8899385923476618,-0.16822230439480612,0.0724035999984297,1.1402398395958966,0.2107857228887916,0.6761588084528414,2682]
["High","O43824","Putative GTP-binding protein 6 [OS=Homo sapiens]",8,4,6,4,516,56.8,9.42,7.75,"","","","","","","","",209.2,212.9,199.3,183.3,174.6,215.9,1.0829557337051239,0.11497427335317652,0.295947399962983,0.5287854711565283,0.4976862586497892,0.303044350164067,4643]
["High","O43829","Zinc finger and BTB domain-containing protein 14 [OS=Homo sapiens]",15,3,3,3,449,50.9,6.04,3.57,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB14","ENSG00000198081","","","",17.7,21.1,16.2,21.6,26.1,26.2,0.7442489851150201,-0.4261427457341293,0.03983779091190622,1.3997047521100077,0.14644702045205452,0.8343194598608038,2124]
["High","O43837-1","isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [OS=Homo sapiens]",17,5,13,5,385,42.2,8.46,27.69,"other metabolic processes","mitochondrion","other molecular function","IDH3B","ENSG00000101365","TCA cycle (aka Krebs or citric acid cycle)","Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids",295.3,329.7,290.4,324.4,294.1,319.8,0.9755941596504316,-0.03564697335492576,0.6491866268641947,0.1876304351472633,0.7951135972636285,0.0995708195946207,6375]
["High","O43847-1","Nardilysin [OS=Homo sapiens]",36,39,93,39,1150,131.5,5,209.19,"","","","","","","","",4105.1,4390.5,4015,3793.3,3967,3930.7,1.070105209135232,0.09775264451047014,0.09402667195609744,1.026748935333362,0.24661076742801777,0.6079879653214514,2977]
["High","O43852","Calumenin [OS=Homo sapiens]",73,26,176,7,315,37.1,4.64,391.11,"","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","CALU","ENSG00000128595","NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling pathway","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",9248.9,8133.9,8319.3,10551.8,8076.1,7597.3,0.9800535362933361,-0.029067535011243182,0.8672087999293361,0.061876323816111224,0.929466892223508,0.03176607526348481,7285]
["High","O43852-4","Isoform 4 of Calumenin [OS=Homo sapiens]",63,21,133,2,323,38.1,4.58,265.73,"","","","CALU","","","","",450,418.5,376.6,547.2,412.9,369.4,0.9365174877773598,-0.09462216043600519,0.6507017005388053,0.18661805828281197,0.7965943677966434,0.09876276853111696,6378]
["High","O43861-1","Probable phospholipid-transporting ATPase IIB [OS=Homo sapiens]",2,2,2,2,1147,129.2,7.61,2.23,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP9B","ENSG00000166377","","Ion transport by P-type ATPases","",92.2,94.9,98.4,96,92.7,93.8,1.0106194690265486,0.01523987806029269,0.6496907253152893,0.18729333297780765,0.79548144633241,0.09936994530642732,6377]
["High","O43865","S-adenosylhomocysteine hydrolase-like protein 1 [OS=Homo sapiens]",45,23,64,12,530,58.9,6.89,117.82,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","AHCYL1","ENSG00000168710","Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways","Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation","Cysteine and methionine metabolism; Metabolic pathways",2187,2151.7,2145.2,1993.9,2040.8,2104.2,1.0561989933049893,0.07888167144663243,0.029007665550374755,1.5374872205039465,0.12086011345641734,0.9177170023970704,1874]
["High","O43896","Kinesin-like protein KIF1C [OS=Homo sapiens]",8,8,13,3,1103,122.9,6.9,28.39,"transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1C","ENSG00000129250","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",70.5,78.5,81,81.3,81.6,97.8,0.882240122746452,-0.1807567217038185,0.1798340364011743,0.7451281078070154,0.36805875654531295,0.43408284543927933,3815]
["High","O43909","exostosin-like 3 [OS=Homo sapiens]",9,8,9,8,919,104.7,6.51,23.42,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","EXTL3","ENSG00000012232","Proteoglycan biosynthesis","XBP1(S) activates chaperone genes","Glycosaminoglycan biosynthesis; Metabolic pathways",495.3,490.6,540.7,497.7,551.4,500,0.9854754373507199,-0.02110818186712925,0.7676351059419493,0.1148451720707004,0.8713032282591568,0.05983067686166629,6879]
["High","O43913","Origin recognition complex subunit 5 [OS=Homo sapiens]",12,7,17,7,435,50.3,7.74,26.53,"DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC5","ENSG00000164815","Cell cycle; G1 to S cell cycle control; DNA replication","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle",1235.1,1222.9,1208.8,1236.4,1337.1,1322,0.9412912334745219,-0.08728693613730973,0.07741461809531,1.111177024346867,0.21868789366431998,0.6601752583903924,2764]
["High","O43924","Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [OS=Homo sapiens]",29,3,5,3,150,17.4,5.67,9.61,"other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PDE6D","ENSG00000156973","Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies","ARL13B-mediated ciliary trafficking of INPP5E; RAS processing","Purine metabolism; Metabolic pathways",168.1,177,137.9,132.5,183.4,157.9,1.0194174757281556,0.02774499048290456,0.8787504081329311,0.05613446026533303,0.9351619444871101,0.029113174681471617,7337]
["High","O43929","origin recognition complex subunit 4 [OS=Homo sapiens]",22,8,13,8,436,50.3,8,29.82,"DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC4","ENSG00000115947","Cell cycle; G1 to S cell cycle control; DNA replication","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle",498,543.5,505,508.4,598.9,555.5,0.9300577339427472,-0.10460781964774556,0.26202159959719756,0.5816629063931474,0.46078032649885553,0.3365060718491319,4440]
["High","O43933","Peroxisome biogenesis factor 1 [OS=Homo sapiens]",7,10,13,10,1283,142.8,6.33,32.41,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","PEX1","ENSG00000127980","","Peroxisomal protein import","Peroxisome",553.6,574.5,543.8,566.5,598.5,566,0.9658578856152512,-0.05011716545473951,0.23365174112101822,0.6314309783613321,0.42956270183021195,0.3669734346933761,4247]
["High","O60216","Double-strand-break repair protein rad21 homolog [OS=Homo sapiens]",50,23,72,23,631,71.6,4.65,170.12,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RAD21","ENSG00000164754","Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin","Cell cycle",1609.9,1552.5,1571.7,1829.1,1786.6,1720.3,0.8872001499250376,-0.17266848559142525,0.005014538202133404,2.299769055764147,0.04404219829275323,1.3561310120757253,889]
["High","O60231","Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [OS=Homo sapiens]",23,22,50,22,1041,119.2,6.8,112.69,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DHX16","ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",1936.7,1880.6,1925.8,2100.8,1996.7,2018.3,0.9390594852676674,-0.090711545759663,0.026192014764688864,1.5818310931161177,0.11393161631347669,0.9433557413718202,1795]
["High","O60232","Sjoegren syndrome/scleroderma autoantigen 1 [OS=Homo sapiens]",19,2,2,2,199,21.5,5.24,7.53,"cell cycle OR cell proliferation;other biological processes","","","ZNRD2","ENSG00000173465","","","",87.3,91.9,95.1,109.5,73.5,69,1.0884920634920634,0.12233088846099836,0.598449179402063,0.2229727241921889,0.7584306432026146,0.12008412832696305,6161]
["High","O60244","Mediator of RNA polymerase II transcription subunit 14 [OS=Homo sapiens]",5,6,8,6,1454,160.5,8.73,11.51,"other biological processes","nucleus","other molecular function","MED14","ENSG00000180182","Vitamin D in inflammatory diseases","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",263.7,281.7,248.5,279.2,301.5,308.1,0.893226822682268,-0.16290152042909095,0.0714542695859068,1.1459718158275278,0.2088005003468414,0.6802684649724005,2672]
["High","O60256-1","Phosphoribosyl pyrophosphate synthase-associated protein 2 [OS=Homo sapiens]",37,11,32,10,369,40.9,7.44,86.18,"other metabolic processes;other biological processes","other cell component","enzyme regulator activity;other molecular function","PRPSAP2","ENSG00000141127","","","",964.6,985.8,916.7,933.7,1001.1,895.3,1.01307374297728,0.01873919364097007,0.7560371123213796,0.12145688534431283,0.8651821446585566,0.06289245196558364,6823]
["High","O60264","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 [OS=Homo sapiens]",51,55,207,40,1052,121.8,8.09,440.83,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCA5","ENSG00000153147","","Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression","",9178.9,8607.8,9113.7,9522.2,9921.9,9937.6,0.9155494746730107,-0.12729024607192885,0.021567822238965407,1.666193704565887,0.1001198311782651,0.9994798913691451,1682]
["High","O60268-1","Uncharacterized protein KIAA0513 [OS=Homo sapiens]",6,2,2,2,411,46.6,5.06,5.53,"","other cell component","","KIAA0513","ENSG00000135709","","","",173.7,181.9,183,142.8,130.2,152.6,1.2655075187969924,0.3397160790004822,6.1153903052000155E-3,2.213575819578597,0.049378456569805294,1.3064624890029635,967]
["High","O60271-2","Isoform 2 of C-Jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",27,31,84,27,1311,145,5.19,198.73,"","","","SPAG9","","","","",4354.5,4151.4,4182.6,3546.6,3551.8,3381.1,1.2107924996421586,0.2759516434077489,9.5238144144216036E-4,3.0211890760535822,0.020656095263278856,1.684951772162234,360]
["High","O60281-1","zinc finger protein 292 [OS=Homo sapiens]",7,12,13,12,2723,304.6,7.39,11.68,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF292","ENSG00000188994","","","",237.9,209.8,192.1,204.6,200.9,200.2,1.0562984976060756,0.07901758106304439,0.4442026280095039,0.352418876389414,0.638500390187446,0.19483883300322383,5432]
["High","O60282-1","kinesin heavy chain isoform 5C [OS=Homo sapiens]",46,39,132,24,957,109.4,6.19,281.38,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF5C","ENSG00000168280; ENSPPAG00000031052; ENSPTRG00000012521","Alzheimer's disease and miRNA effects; Alzheimer's disease","Insulin processing","Endocytosis; Dopaminergic synapse; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Salmonella infection; Non-small cell lung cancer",3720.3,3379.1,3805.2,3605.2,3293.6,3436.1,1.0551239005699136,0.07741242096301966,0.2965397585236224,0.52791707042843,0.49782464729143056,0.30292360528131107,4651]
["High","O60287","nucleolar pre-ribosomal-associated protein 1 [OS=Homo sapiens]",15,23,35,23,2271,254.2,6.47,67.46,"RNA metabolism OR transcription;other metabolic processes","nucleus","","URB1","ENSG00000142207","","","",1147.7,1191.5,1110,944,960.7,974.5,1.1979716587941096,0.2605937777420234,0.001644035591771785,2.784088784641,0.02679880981326534,1.5718844933969276,479]
["Low","O60290-1","Zinc finger protein 862 [OS=Homo sapiens]",1,1,2,1,1169,131.6,7.23,0,"other biological processes","nucleus","other molecular function","ZNF862","ENSG00000106479","","","",12.7,19.3,12.7,12.9,11.6,16.5,1.0902439024390245,0.12465092167787183,0.6650895389083311,0.17711988306363302,0.8069959782123154,0.0931286296454031,6435]
["High","O60291-1","E3 ubiquitin-protein ligase MGRN1 [OS=Homo sapiens]",22,7,9,7,552,60.7,5.15,21.71,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGRN1","ENSG00000102858","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis; Hedgehog signaling pathway",187.4,200.2,193.7,166.8,210.7,213.2,0.9840866768241069,-0.023142703390824044,0.8497955765939387,0.07068553385587537,0.9206610048626992,0.0359002512566822,7207]
["High","O60293","Zinc finger C3H1 domain-containing protein [OS=Homo sapiens]",11,16,21,16,1989,226.2,8.13,32.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","ZFC3H1","ENSG00000133858","","","",506.4,452.6,494.3,687.2,655.2,659.3,0.72603287205875,-0.4618932253405411,6.7225992353429985E-4,3.1724627782390926,0.018100018906744186,1.7423209714794132,290]
["High","O60294","tRNA wybutosine-synthesizing protein 4 [OS=Homo sapiens]",3,2,3,2,686,75.6,6.73,3.23,"RNA metabolism OR transcription;other metabolic processes","other cell component","other molecular function","LCMT2","ENSG00000168806","","Synthesis of wybutosine at G37 of tRNA(Phe)","",74.4,86.4,78.7,77.9,90.5,80.4,0.9626205787781349,-0.05496082950706018,0.5839398713063588,0.23363187018943604,0.7485474495419553,0.12578066503222193,6091]
["High","O60299-1","Leucine zipper putative tumor suppressor 3 [OS=Homo sapiens]",4,2,2,2,673,71.7,7.64,6.26,"other biological processes","cytoskeleton;other cell component","","LZTS3","ENSG00000088899; ENSGGOG00000008647; ENSPTRG00000013192","","","",27.9,33.7,25.2,28,22.7,22.6,1.1841746248294678,0.24388184431066726,0.21745444525395716,0.6626317099598696,0.41200783997643714,0.38509451982582255,4121]
["High","O60306","Intron-binding protein aquarius [OS=Homo sapiens]",15,18,39,17,1485,171.2,6.37,84.98,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","AQR","ENSG00000021776","","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","Spliceosome",1538.8,1587.4,1447.9,1522.1,1745.8,1568.6,0.9457458906233847,-0.08047549227794419,0.3328606466663123,0.4777375474264983,0.5345487308043124,0.2720126972751798,4862]
["High","O60307","Microtubule-associated serine/threonine-protein kinase 3 [OS=Homo sapiens]",4,5,9,3,1309,143,8.06,4.49,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","","kinase activity;other molecular function","MAST3","ENSG00000099308","","","",307.6,253.8,273.1,343.5,317.8,310.8,0.8584507766690671,-0.22019268202438264,0.06937509903988445,1.158796383870066,0.2051821110997795,0.6878605060812615,2640]
["High","O60313-2","Isoform 2 of Dynamin-like 120 kDa protein, mitochondrial [OS=Homo sapiens]",36,30,78,30,997,115.8,7.87,168.46,"","","","OPA1","","","","",3461.4,3409.9,3379.7,3953.8,4293.4,4203.4,0.8233338152378199,-0.2804506144889245,0.002160784035136088,2.665388637575657,0.029808130293891472,1.525665264105293,566]
["High","O60318","Germinal-center associated nuclear protein [OS=Homo sapiens]",13,16,20,16,1980,218.3,6.39,57.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3AP","ENSG00000160294","","","",829.4,812.9,775.2,831,810.1,877.9,0.959706232631997,-0.05933523237003747,0.25796864826559773,0.588433071992607,0.45611847954207135,0.3409223320551141,4416]
["High","O60331","Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [OS=Homo sapiens]",6,4,4,4,668,73.2,5.29,9.33,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIP5K1C","ENSG00000186111","B cell receptor signaling pathway; Focal adhesion; Regulation of actin cytoskeleton","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer",210.4,246.9,225.7,185.1,183.5,192.6,1.2170349251603705,0.28337056955755346,0.020681329521780718,1.6844215455871367,0.09774807560899748,1.009891783912865,1652]
["High","O60333","Kinesin-like protein KIF1B [OS=Homo sapiens]",14,21,40,2,1816,204.3,5.6,93.91,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1B","ENSG00000054523","Intracellular trafficking proteins involved in CMT neuropathy","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",546.7,542.3,544.9,618.4,614.4,596.1,0.8933785335447537,-0.1626565054808034,7.4096070614254855E-4,3.1302048224632433,0.018783835044029282,1.726215734305052,308]
["High","O60333-3","Isoform 3 of Kinesin-like protein KIF1B [OS=Homo sapiens]",21,19,33,4,1153,130.3,8.43,68.92,"","","","KIF1B","","","","",215.1,203.6,209.5,263.3,233.3,229.8,0.8648127753303965,-0.2095402596389504,0.0424341484237171,1.3722845089012907,0.15184501874078055,0.8185994504949785,2182]
["High","O60337","E3 ubiquitin-protein ligase MARCH6 [OS=Homo sapiens]",2,2,2,2,910,102.5,6.28,2.75,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","MARCHF6","ENSG00000145495","","ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",118.6,131.8,145.9,146.6,134,151.4,0.9173611111111111,-0.12443834508284714,0.2758302016445475,0.5593581830859712,0.4760570765783879,0.32234097468075346,4524]
["High","O60341","Lysine-specific histone demethylase 1A [OS=Homo sapiens]",59,30,92,30,852,92.8,6.52,245.15,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM1A","ENSG00000004487","Androgen receptor signaling pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects","Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Thermogenesis",3273.1,3347.8,3287.1,3322.6,3201.8,3453.3,0.9930144221614199,-0.010113423830929905,0.7755165579183693,0.11040892520587335,0.8757930697464025,0.05759849575362598,6914]
["High","O60343-1","TBC1 domain family member 4 [OS=Homo sapiens]",13,14,26,14,1298,146.5,7.01,51.72,"transport;other biological processes","cytosol;other cell component","enzyme regulator activity","TBC1D4","ENSG00000136111","Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane","Thyroid hormone signaling pathway; Insulin resistance; Diabetic cardiomyopathy",593,635,640.3,691.9,672.4,683.8,0.9122113178067478,-0.13256002506181458,0.01999957422472602,1.6989792500270349,0.09586045153263399,1.0183605296769087,1629]
["High","O60344-1","Endothelin-converting enzyme 2 [OS=Homo sapiens]",5,3,8,3,883,99.7,5.1,11.83,"protein metabolism;other metabolic processes;developmental processes","plasma membrane;other membranes;ER/Golgi","other molecular function","EEF1AKMT4-ECE2","ENSG00000284917","","","",187.3,220.7,207.7,189.7,184.9,179,1.1121748554913296,0.15338362557836313,0.11231139038963113,0.9495761962540474,0.27421117453478416,0.561914851005628,3198]
["High","O60353-1","Frizzled-6 [OS=Homo sapiens]",7,4,5,4,706,79.2,7.96,6.4,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","FZD6","ENSG00000164930","Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","Class B/2 (Secretin family receptors); Ca2+ pathway; PCP/CE pathway; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",204.3,186.3,205.7,171.1,179.8,189.8,1.1028296652487515,0.1412099803421707,0.08821926476214663,1.0544365660438186,0.23719559891971104,0.6248933734132394,2904]
["High","O60427","Fatty acid desaturase 1 [OS=Homo sapiens]",4,2,4,2,444,51.9,8.87,7.33,"cell-cell signaling;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","FADS1","ENSG00000149485","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection","PPARA activates gene expression; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism",367.5,405.6,346.7,405.9,428.4,423.4,0.8903554106702711,-0.1675467511019809,0.06831615642320701,1.1654765757374979,0.20328222155198183,0.6919006017824851,2624]
["High","O60437","periplakin [OS=Homo sapiens]",29,51,83,51,1756,204.6,5.6,173.43,"cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PPL","ENSG00000118898","","Formation of the cornified envelope; Butyrophilin (BTN) family interactions","",4582.2,3931.9,4353.6,3553.2,3262.4,3223,1.281822166437551,0.3581961235832374,0.012210383559999467,1.913270693518271,0.07261132889297474,1.138995614949115,1313]
["High","O60443","Non-syndromic hearing impairment protein 5 [OS=Homo sapiens]",9,4,7,4,496,54.5,5.17,20.01,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","transporter activity;other molecular function","GSDME","ENSG00000105928","","Regulation of TLR by endogenous ligand; Release of apoptotic factors from the mitochondria; Pyroptosis; Defective pyroptosis","",273,290.6,287.1,244.5,300.8,270.2,1.0431637032495402,0.060965577161596125,0.5312028073652101,0.2747396384216698,0.7099677370605205,0.1487613864005653,5842]
["High","O60447","Ecotropic viral integration site 5 protein homolog [OS=Homo sapiens]",4,3,3,3,810,92.9,6.1,9.69,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","EVI5","ENSG00000067208","","","",211.3,213.4,201.4,233.7,214.6,196.4,0.9711493718008378,-0.04223488226794814,0.6150288002705837,0.21110454681688784,0.7727944757825422,0.1119359910772081,6214]
["High","O60462-1","Neuropilin-2 [OS=Homo sapiens]",3,2,2,2,931,104.8,5.17,3.8,"","","","","","","","",22,20.4,15.6,23.5,21.7,17.6,0.9235668789808916,-0.11471165887669268,0.5711946164250741,0.24321589448801198,0.7403531814487015,0.13056105302202078,6024]
["High","O60476","mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [OS=Homo sapiens]",11,5,7,5,641,73,7.61,10.76,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","MAN1A2","ENSG00000198162","","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum",165.3,179,161.1,155.9,164.9,170.7,1.0282807731434385,0.04023424771683215,0.5392385727693134,0.2682190494443593,0.7155633542118965,0.1453519088412164,5884]
["High","O60481","Zinc finger protein ZIC 3 [OS=Homo sapiens]",5,3,5,2,467,50.5,8.65,8.13,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZIC3","ENSG00000156925","Mesodermal commitment pathway","POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","Signaling pathways regulating pluripotency of stem cells",348.1,365.5,369.3,359.3,358,364.6,1.000924299842869,1.332866910112166E-3,0.9634214537994454,0.016183686895391913,0.9822923362844176,0.007759244248425316,7658]
["High","O60488-1","Long-chain-fatty-acid--CoA ligase 4 [OS=Homo sapiens]",30,16,48,13,711,79.1,8.38,113.55,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL4","ENSG00000068366","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway",1989.3,2052.5,1913.3,1842.1,2124.2,2078.5,0.9851607993647434,-0.021568872335967132,0.7715469875642579,0.11263762006294323,0.8734578626796761,0.05875804139324929,6897]
["Medium","O60493-1","sorting nexin-3 [OS=Homo sapiens]",9,1,1,1,162,18.8,8.66,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","LOC111158258; Snx3; SNX3; Snx3_1","ENSAMEG00000008145; ENSANAG00000028701; ENSBIXG00000016466; ENSBIXG00005007963; ENSBMUG00000010256; ENSBTAG00000018801; ENSCANG00000036155; ENSCATG00000029122; ENSCCAG00000022069; ENSCGRG00015001325; ENSCHIG00000003391; ENSCJAG00000005955; ENSCSAG00000015156; ENSDLEG00000017815; ENSFCAG00000024997; ENSG00000112335; ENSLCNG00005012116; ENSMFAG00000039300; ENSMMNG00015010894; ENSMMUG00000020366; ENSMNEG00000027766; ENSMPUG00000009812; ENSMUSG00000019804; ENSNVIG00000004406; ENSOARG00000010805; ENSPANG00000017995; ENSPCOG00000020531; ENSPCTG00005013214; ENSPPAG00000032382; ENSPPYG00000016894; ENSPTRG00000018473; ENSPTRG00000046352; ENSRFEG00010011106; ENSRROG00000037899; ENSSBOG00000028606; ENSSSCG00000004385; ENSSSCG00070023370; ENSSSUG00005019212; ENSSTOG00000007274; ENSTSYG00000035289; ENSTTRG00000008868; ENSUAMG00000027552","","Ub-specific processing proteases; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking","Endocytosis",28,29,27.8,38.1,27.7,19.6,0.9929742388758781,-0.010171805057291377,0.972059928112412,0.012306959717509999,0.9856940154158069,0.006257880231356465,7700]
["Medium","O60499","Syntaxin-10 [OS=Homo sapiens]",4,1,1,1,249,28.1,4.89,2.33,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","STX10","ENSG00000104915","","Retrograde transport at the Trans-Golgi-Network","Salmonella infection",50.7,62.2,57.5,51,50.8,63.1,1.033353547604609,0.0473339367883713,0.7450785109854645,0.1277979620285512,0.8586823636567538,0.06616745691635914,6775]
["High","O60502","protein O-GlcNAcase [OS=Homo sapiens]",30,25,64,25,916,102.8,4.91,110.82,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","OGA","ENSG00000198408","","","Insulin resistance",2433,2321.3,2398.6,2684.2,2717.5,2570.9,0.8971853598575119,-0.1565220159626102,0.007818426959713092,2.106880616689102,0.05668178059558015,1.246556515328448,1077]
["High","O60504-1","Vinexin [OS=Homo sapiens]",10,5,5,5,671,75.3,9.45,8.12,"cell adhesion;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","SORBS3","ENSG00000120896","","Smooth Muscle Contraction","",149.5,137.8,125.3,144.8,147.3,165.1,0.9024496937882764,-0.14808158232799357,0.19149922118663856,0.7178329879357401,0.38250854925179684,0.4173588537093519,3909]
["High","O60506","Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",57,31,235,2,623,69.6,8.59,555.55,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","SYNCRIP","ENSG00000135316","","","",9121.8,8735.8,9181,9705.2,9694.4,9750,0.9275804813788183,-0.10845563250829073,0.007468633509142613,2.1267588511600324,0.055118232929475916,1.258704714200564,1058]
["High","O60506-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",55,29,216,1,562,62.6,7.56,498.21,"","","","SYNCRIP","","","","",107.8,86.2,98.8,124.2,127.7,113.8,0.8006562756357671,-0.3207450730573256,0.0320313629044683,1.494424582119902,0.12734260771796765,0.8950262609121974,1964]
["High","O60507","Protein-tyrosine sulfotransferase 1 [OS=Homo sapiens]",5,2,2,2,370,42.2,9.09,2.99,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","TPST1","ENSG00000169902","","Cytosolic sulfonation of small molecules; Gamma carboxylation, hypusine formation and arylsulfatase activation; Defective F8 sulfation at Y1699","",135.2,164.6,135.9,129.4,120.1,125.9,1.1606286627597229,0.21490646308429334,0.11632614393459868,0.9343226679841117,0.2801587081558749,0.5525958738379725,3242]
["High","O60508","pre-mRNA-processing factor 17 [OS=Homo sapiens]",25,12,18,12,579,65.5,7.06,29.06,"RNA metabolism OR transcription;other metabolic processes","nucleus","","CDC40","ENSG00000168438","mRNA processing","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","Spliceosome",658.7,664.1,628.7,741.2,640,684.3,0.94480755265069,-0.08190759741716852,0.29137678404839756,0.5355450543550991,0.4925459904416298,0.3075532119430105,4619]
["High","O60512","beta-1,4-galactosyltransferase 3 [OS=Homo sapiens]",5,2,4,2,393,43.9,9.25,8.84,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi","other molecular function","B4GALT3","ENSG00000158850","","N-Glycan antennae elongation; Keratan sulfate biosynthesis","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways",172,184.1,164.2,154.8,167.7,179.2,1.0370739485748455,0.05251876921239563,0.5339422437448318,0.2725057178393942,0.7120445839726126,0.1474928125891407,5855]
["High","O60513","Beta-1,4-galactosyltransferase 4 [OS=Homo sapiens]",6,2,2,2,344,40,9.07,5.73,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B4GALT4","ENSG00000121578","","N-Glycan antennae elongation; Keratan sulfate biosynthesis","Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways",114.9,137.3,108.8,100.9,115.5,106.9,1.116609959789669,0.1591253296484479,0.2625300943299989,0.5808209053920501,0.4615705869238081,0.3357618739070906,4441]
["High","O60518","ran-binding protein 6 [OS=Homo sapiens]",4,4,30,1,1105,124.6,5.01,33.4,"transport","nucleus;other cell component","other molecular function","RANBP6","ENSG00000137040","","","",33.4,36.1,45,31.5,34,41,{"$f":"AVERAGE(T514:V514)/AVERAGE(W514:Y514)","v":1.0751173708920188},{"$f":"LOG(Z514,2)","v":0.10449416787110566},{"$f":"TTEST(T514:V514,W514:Y514,2,2)","v":0.5863452664430657},{"$f":"-LOG10(AB514)","v":0.23184657655104896},{"$f":"AB514*7808/AF514","v":0.7496616735528832},{"$f":"-LOG10(AD514)","v":0.12513469188827914},6107]
["High","O60524","nuclear export mediator factor NEMF [OS=Homo sapiens]",16,16,29,16,1076,122.9,6.35,56.39,"protein metabolism;other metabolic processes;transport","nucleus;other cell component","translation activity;nucleic acid binding activity","NEMF","ENSG00000165525","","","",1173.7,1233.6,1236.3,1296.5,1315.3,1244.4,0.9448680047715369,-0.081815291651087,0.07383033448102935,1.131765164044875,0.21303298286322145,0.6715531516478437,2706]
["High","O60547-1","GDP-mannose 4,6 dehydratase [OS=Homo sapiens]",24,8,14,8,372,41.9,7.31,28.11,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","GMDS","ENSG00000112699; ENSPPAG00000026874; ENSPPYG00000016168; ENSPTRG00000017663","","GDP-fucose biosynthesis","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",1035.6,1126.2,993.3,990.5,1117.4,1050.1,0.9990816972767574,-1.3254394553733795E-3,0.9864920027039152,5.9064311372212484E-3,0.9937465562007703,0.002724363367517309,7751]
["High","O60551","Glycylpeptide N-tetradecanoyltransferase 2 [OS=Homo sapiens]",13,6,24,2,498,56.9,7.58,43.67,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NMT2","ENSG00000152465","","Membrane binding and targetting of GAG proteins; Inactivation, recovery and regulation of the phototransduction cascade","",136.4,106.3,114.1,116.3,107.7,115.2,1.0518867924528301,0.07297944535710546,0.5669742261599384,0.24643668306640767,0.7364722604985525,0.132843606376389,6011]
["High","O60563","Cyclin-T1 [OS=Homo sapiens]",17,10,15,10,726,80.6,8.78,34.59,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","CCNT1","ENSG00000129315","Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins","Transcriptional misregulation in cancer",1129.3,1116.3,1193.5,1003.2,929,1013.6,1.1674587548373954,0.22337158184701425,0.010046753247345351,1.9979742640719416,0.06548000780907555,1.1838912774665986,1198]
["High","O60566","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta [OS=Homo sapiens]",29,25,53,25,1050,119.5,5.27,104.76,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","BUB1B","ENSG00000156970","Regulation of sister chromatid separation at the metaphase-anaphase transition","Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Human T-cell leukemia virus 1 infection",2620.4,2673.5,2582.9,2305.4,2115.5,2134.9,1.201500960981116,0.26483780236052673,2.594112145381034E-3,2.5860112529753847,0.031305761408245925,1.5043757289854496,647]
["High","O60568","Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [OS=Homo sapiens]",29,18,53,18,738,84.7,6.05,89.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi","other molecular function","PLOD3","ENSG00000106397","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway","Collagen biosynthesis and modifying enzymes","Lysine degradation; Other types of O-glycan biosynthesis; Metabolic pathways",1613.4,1648.5,1651.9,1689,1710.3,1655.7,0.9720672601384768,-0.04087195337003385,0.07920081883606826,1.1012703283328837,0.22244604081727376,0.6527753195923247,2780]
["High","O60573","eukaryotic translation initiation factor 4E type 2 [OS=Homo sapiens]",42,10,20,10,245,28.3,8.88,48.7,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF4E2","ENSG00000135930","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance","ISG15 antiviral mechanism","EGFR tyrosine kinase inhibitor resistance; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Longevity regulating pathway; Insulin signaling pathway",1146.3,1151.7,1111.1,1109.4,1113.3,1111.1,1.0225868378427019,0.032223361705390884,0.12097859543602521,0.9172914619672425,0.2878125756137979,0.5408902340256816,3282]
["High","O60583-2","Isoform 2 of Cyclin-T2 [OS=Homo sapiens]",16,9,15,9,663,73.6,9.14,33.54,"","","","CCNT2","","","","",729.2,714.4,788.8,651.4,596.3,623.7,1.192903708453564,0.2544775929550378,0.012287524148433442,1.9105356156484277,0.07279285929512011,1.1379112212477833,1318]
["High","O60610-1","Protein diaphanous homolog 1 [OS=Homo sapiens]",38,45,105,44,1272,141.3,5.41,228.5,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH1","ENSG00000131504","Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway","RHOC GTPase cycle; RHOA GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility","Focal adhesion; Regulation of actin cytoskeleton; AGE-RAGE signaling pathway in diabetic complications; Shigellosis",5505.1,5381.3,5380.2,5340.7,5225.3,5411.3,1.0181069392200186,0.025889106187183195,0.23049999796834839,0.637329074102251,0.4259749074880152,0.3706159827293268,4225]
["High","O60613-1","selenoprotein F [OS=Homo sapiens]",15,2,6,2,162,17.8,5.03,5.79,"","","","","","","","",68.1,75.5,57.5,59,62.4,58.4,1.118464961067853,0.1615200607909043,0.256642314083719,0.5906717374465115,0.4550098066225427,0.3419792430875902,4404]
["High","O60636","tetraspanin-2 [OS=Homo sapiens]",5,1,1,1,221,24.1,7.77,0,"cell organization and biogenesis;stress response;developmental processes","plasma membrane;other membranes;nucleus;other cell component","","TSPAN2","ENSG00000134198","","","",19.4,20.1,23.5,24.7,18,24.5,0.9374999999999999,-0.09310940439148165,0.6107169361393124,0.2141600361694192,0.7688613088319497,0.11415199341209133,6202]
["High","O60637","Tetraspanin-3 [OS=Homo sapiens]",12,4,5,4,253,28,5.81,9.62,"","plasma membrane;other membranes","","TSPAN3","ENSG00000140391","","","",221.7,241.7,256.8,170.1,154.5,174.9,1.441841841841842,0.5279129215105,3.4626181330773905E-3,2.4605954009835354,0.03580943361995797,1.4460025479540881,755]
["High","O60645","exocyst complex component 3 [OS=Homo sapiens]",17,12,20,12,756,86.8,6.11,44.52,"","","","","","","","",814.2,829.9,844.5,820.4,829.9,838.2,1.0000401848503113,5.7973319446225943E-5,0.9975364963093072,1.0712060614766123E-3,0.9994565588583435,2.3607764202388367E-4,7793]
["High","O60664-1","Perilipin-3 [OS=Homo sapiens]",59,23,111,23,434,47,5.44,261.52,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","PLIN3","ENSG00000105355","","Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle; Lipophagy; Chaperone Mediated Autophagy","",4181.5,4183.8,4240.8,4218.7,3908.9,4018,1.0379149650902384,0.05368825056674256,0.17336090952234467,0.7610488231955107,0.360000527008103,0.4436968634645363,3760]
["High","O60671-1","Cell cycle checkpoint protein RAD1 [OS=Homo sapiens]",14,2,4,2,282,31.8,4.83,6.33,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD1","ENSCCAG00000029737; ENSG00000113456; ENSGGOG00000004219; ENSMFAG00000012657; ENSMMUG00000045918; ENSPANG00000024799; ENSPPAG00000028406; ENSPPYG00000015389; ENSPTRG00000016783","miRNA regulation of DNA damage response; ATR signaling; DNA damage response","Presynaptic phase of homologous DNA pairing and strand exchange; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","Cellular senescence",54,42.8,48.2,54,56.3,49.3,0.9085213032581455,-0.13840775132004873,0.2731680546493498,0.5635700901321604,0.4733457990905732,0.32482147286133706,4506]
["High","O60674","Tyrosine-protein kinase JAK2 [OS=Homo sapiens]",1,1,2,1,1132,130.6,7.21,2.52,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK2","ENSG00000096968","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Mesodermal commitment pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; IL-6 signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; Overview of interferons-mediated signaling pathway; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 distal deletion syndrome; CCL18 signaling pathway; EPO receptor signaling; Notch signaling pathway; Type II interferon signaling (IFNG); Serotonin receptor 2 and STAT3 signaling","Potential therapeutics for SARS; Signaling by BRAF and RAF1 fusions; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Signaling by SCF-KIT; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Interleukin-4 and Interleukin-13 signaling; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; RMTs methylate histone arginines; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; RAF activation; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; IL-6-type cytokine receptor ligand interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; PI3K-Akt signaling pathway; Necroptosis; Signaling pathways regulating pluripotency of stem cells; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Cholinergic synapse; Prolactin signaling pathway; Adipocytokine signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis B; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",21.9,23.4,32.6,27.6,30.6,25.2,0.9340527577937651,-0.09842405538299431,0.6455071396903738,0.19009894981741554,0.7929703817971112,0.10074303369412205,6356]
["High","O60678","protein arginine N-methyltransferase 3 [OS=Homo sapiens]",18,8,22,8,531,59.8,5.35,43.19,"","","","","","","","",707.1,755.2,713.8,737.2,737.3,734.9,0.9849280347605686,-0.02190977913761317,0.5020375231172186,0.29926382175191585,0.6866191943421339,0.16328406009996335,5709]
["High","O60684","Importin subunit alpha-7 [OS=Homo sapiens]",44,20,107,12,536,60,4.98,265.21,"transport;other biological processes","nucleus;other cell component","other molecular function","KPNA6","ENSG00000025800","","Assembly of the ORC complex at the origin of replication","Nucleocytoplasmic transport; Influenza A; Chemical carcinogenesis",5038.2,4976.1,5018.7,4905,5048.5,4890.7,1.012718772315113,0.018233599494141186,0.3056209409252854,0.5148168915337985,0.5056766914059395,0.2961270642181123,4719]
["High","O60701","UDP-glucose 6-dehydrogenase [OS=Homo sapiens]",53,21,75,21,494,55,7.12,177.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus","other molecular function","UGDH","ENSG00000109814","Glucuronidation","Formation of the active cofactor, UDP-glucuronate","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",3246.4,3361.5,3184.4,3076.6,3284.9,3283.3,1.0152932149966822,0.02189643552083097,0.6000128476642004,0.2218394502664725,0.7599189480230456,0.11923272653958758,6165]
["High","O60716-1","Catenin delta-1 [OS=Homo sapiens]",46,35,142,35,968,108.1,6.23,291.16,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","CTNND1","ENSG00000198561","VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency","VEGFR2 mediated vascular permeability; Adherens junctions interactions; InlA-mediated entry of Listeria monocytogenes into host cells","Rap1 signaling pathway; Adherens junction; Leukocyte transendothelial migration",5685.6,5650,5887.1,6556.4,6110.7,6218.4,0.9119536152074343,-0.13296764858071725,0.022407990378553087,1.6495970906599522,0.1029791576667113,0.9872506648703625,1699]
["High","O60725","protein-s-isoprenylcysteine O-methyltransferase [OS=Homo sapiens]",6,2,3,2,284,31.9,7.96,5.94,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ICMT","ENSG00000116237","Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome","RAS processing; Gamma carboxylation, hypusine formation and arylsulfatase activation","Terpenoid backbone biosynthesis",332.2,329.3,322.9,344.4,350.4,349.8,0.9423702852766609,-0.08563404591409751,0.003884107827350482,2.4107087220767784,0.03805158584184763,1.4196272388142555,797]
["Medium","O60729-1","Dual specificity protein phosphatase CDC14B [OS=Homo sapiens]",2,1,1,1,498,56.8,9.03,1.72,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CDC14B","ENSG00000081377; ENSPPYG00000019417; ENSPTRG00000021155","Cell cycle; Cell cycle","MAPK6/MAPK4 signaling","Cell cycle",65.9,57.2,55.6,82.5,87.8,66.2,0.7556025369978859,-0.4043005491852668,0.05641958952944199,1.2485700778004114,0.18136029437870854,0.7414577879469065,2429]
["High","O60749","Sorting nexin-2 [OS=Homo sapiens]",30,15,58,13,519,58.4,5.12,116.69,"cell organization and biogenesis;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX2","ENSG00000205302","","Golgi Associated Vesicle Biogenesis","Endocytosis",2893.2,2954.7,2873.3,2761.6,2871.4,2864.9,1.0262770802198191,0.03742029068360373,0.15989767879245795,0.7961578407874985,0.3434610938133457,0.46412245132391977,3635]
["High","O60762","Dolichol-phosphate mannosyltransferase subunit 1 [OS=Homo sapiens]",30,6,23,6,260,29.6,9.57,40.23,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DPM1","ENSG00000000419","VEGFA-VEGFR2 signaling pathway","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","N-Glycan biosynthesis; Metabolic pathways",802.3,872,838.2,879.8,909.8,925.2,0.9254825401502873,-0.1117223219456995,0.0491288142667207,1.3086637175186375,0.16634769375305952,0.7789832158186824,2306]
["High","O60763-1","General vesicular transport factor p115 [OS=Homo sapiens]",42,38,134,38,962,107.8,4.91,304.95,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","USO1","ENSG00000138768","","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization","",6007.4,5424,5855.7,6021.5,6021.1,5974.7,0.959472284970556,-0.05968696112227651,0.2376403907230324,0.6240797422374588,0.43433899128404424,0.3621711815993233,4272]
["High","O60784","Target of Myb protein 1 [OS=Homo sapiens]",25,10,19,10,492,53.8,4.7,26.27,"transport;signal transduction","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","TOM1","ENSG00000100284","","Neutrophil degranulation","",399,371.3,410,426.8,337.5,362.5,1.0474795882144126,0.06692213101888855,0.571633525092384,0.24288230868500418,0.7404304186996241,0.13051574766896296,6028]
["High","O60825-1","6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",41,17,41,1,505,58.4,8.38,68.77,"other metabolic processes;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PFKFB2","ENSG00000123836; ENSGGOG00000012227; ENSPPAG00000041619; ENSPTRG00000001925","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects","Regulation of glycolysis by fructose 2,6-bisphosphate metabolism","Fructose and mannose metabolism; Metabolic pathways; AMPK signaling pathway; Thyroid hormone signaling pathway",1281.6,1305.4,1190.6,1165.5,1261,1257.1,1.025518514496688,0.036353538167291644,0.5404542038305045,0.2672411007233314,0.7166892702969733,0.14466909739413847,5888]
["High","O60825-2","Isoform 2 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",45,17,40,1,471,54.4,7.56,67.1,"","","","PFKFB2","","","","",46.2,55,59.8,48.7,51.2,44.8,1.1126468555632343,0.15399576647025473,0.2840975172533538,0.5465325615881511,0.4844362119926155,0.3147634004572131,4579]
["High","O60826","Coiled-coil domain-containing protein 22 [OS=Homo sapiens]",16,8,11,8,627,70.7,6.74,31.95,"transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","CCDC22","ENSG00000101997","","Neddylation","",520.6,524.7,501.5,599.8,537.1,562.6,0.9101500441306267,-0.1358236923462269,0.05988896575669219,1.222653186832971,0.18862970739340565,0.7243899089421573,2479]
["High","O60828","Polyglutamine-binding protein 1 [OS=Homo sapiens]",42,9,24,9,265,30.5,6.33,63.4,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PQBP1","ENSG00000102103","","mRNA Splicing - Major Pathway","Spliceosome",1190.2,1166,1165,1277.1,982.8,902.9,1.1133173137726067,0.15486484313946622,0.3540928627276978,0.45088282700979576,0.5560653805667466,0.25487414232076755,4972]
["High","O60830-1","Mitochondrial import inner membrane translocase subunit Tim17-B [OS=Homo sapiens]",33,4,14,4,172,18.3,9.03,34.75,"cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity","TIMM17B","ENSG00000126768; ENSGGOG00000011427; ENSNLEG00000007902; ENSPPAG00000036547; ENSPPYG00000020323; ENSPTRG00000021872","","Mitochondrial protein import","",450.2,450.5,433.6,459.2,464.2,464.2,0.9615883539925052,-0.056508671528574535,0.03807281280048865,1.4193850365398537,0.14264516427361584,0.8457429465087053,2084]
["High","O60831","PRA1 family protein 2 [OS=Homo sapiens]",16,3,6,3,178,19.2,9.19,8.51,"transport","other membranes;other cytoplasmic organelle","","PRAF2","ENSG00000243279","","","",293.4,293.4,362.7,287.7,253.4,299.5,1.1295503211991436,0.1757485438848857,0.24883289916079318,0.6040922004304985,0.446948993937767,0.34974203596270015,4347]
["High","O60832-1","H/ACA ribonucleoprotein complex subunit 4 [OS=Homo sapiens]",45,21,88,21,514,57.6,9.42,241.12,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DKC1","ENSG00000130826; ENSGGOG00000001045; ENSPTRG00000022449","","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","Ribosome biogenesis in eukaryotes",3907,3917.8,3834.4,4060.1,4297.8,4232.3,0.9260535972422995,-0.11083240006494814,0.01477169570603741,1.830569647307952,0.08076848744589643,1.092758050089472,1428]
["High","O60841","Eukaryotic translation initiation factor 5B [OS=Homo sapiens]",39,50,196,49,1220,138.7,5.49,410.84,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","EIF5B","ENSG00000158417","Translation factors; Ciliary landscape","GTP hydrolysis and joining of the 60S ribosomal subunit","",9560.6,9242.6,9486.8,9088.2,8914,9221.6,1.0391642606836664,0.05542371905751531,0.053388491654149585,1.2725523487718553,0.1752237674802858,0.7564069861504861,2379]
["High","O60858","E3 ubiquitin-protein ligase TRIM13 [OS=Homo sapiens]",15,5,5,5,407,47,6.01,7.74,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","TRIM13","ENSG00000204977","","ER Quality Control Compartment (ERQC)","",80.3,77,54.7,65.2,58.5,61.8,1.1428571428571428,0.19264507794239583,0.3456093094987156,0.46141456767037803,0.5479223327037505,0.26128099784537323,4925]
["High","O60870","DNA/RNA-binding protein KIN17 [OS=Homo sapiens]",33,13,23,12,393,45.3,8.95,49.7,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","KIN","ENSG00000151657","","Protein methylation","",958.3,961.1,941.2,1150.4,1039.2,1125.1,0.863004193441337,-0.21256052523710342,0.011483408507461986,1.9399291854337193,0.07071171421629589,1.1505086343207978,1268]
["High","O60879","Protein diaphanous homolog 2 [OS=Homo sapiens]",11,11,15,11,1101,125.5,6.58,30.96,"cell organization and biogenesis;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH2","ENSG00000147202","","RHOF GTPase cycle","Regulation of actin cytoskeleton",683.6,698.9,676.1,807.1,752.3,750,0.891400363730839,-0.1658545452531844,0.013525275362952602,1.8688538842699352,0.07658110952424504,1.1158783457871495,1379]
["High","O60884","DnaJ homolog subfamily A member 2 [OS=Homo sapiens]",49,18,78,18,412,45.7,6.48,164.08,"stress response;other biological processes","other membranes;cytosol","other molecular function","DNAJA2","ENSG00000069345","","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","Protein processing in endoplasmic reticulum",3608.2,3506.3,3745.8,3983.3,3820.9,3987.9,0.9209809957513928,-0.11875670797150602,0.024675465299455204,1.6077346491920417,0.10922110717581987,0.9616934253292072,1764]
["High","O60885-1","Bromodomain-containing protein 4 [OS=Homo sapiens]",12,13,29,10,1362,152.1,9.19,40.31,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD4","ENSG00000141867; ENSPTRG00000010619","VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome","Potential therapeutics for SARS","",764.8,688.1,740.4,2378.7,2148.6,2261.3,0.3230857614235631,-1.630010923288281,2.6066214074444522E-5,4.5839220423252005,0.005814999985521795,2.2354502820168407,35]
["High","O60888-1","Protein CutA [OS=Homo sapiens]",25,3,30,3,179,19.1,5.5,46.54,"other biological processes","other membranes","other molecular function","CUTA","ENSG00000112514; ENSG00000226492","","","",690.5,733,716.2,643.8,637.9,642.1,1.1122258030980352,0.1534497124672232,0.004490563187999131,2.3476991881499165,0.04144481958853099,1.3825297465303046,846]
["High","O60890","Oligophrenin-1 [OS=Homo sapiens]",3,2,3,2,802,91.6,7.96,6.85,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","OPHN1","ENSG00000079482","","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle","",33.5,36.7,39.7,41.7,38.7,43.4,0.8877221324717285,-0.17181992826503373,0.10928747924845744,0.9614295910675227,0.2698661094155458,0.5688516520050775,3162]
["High","O60906","Sphingomyelin phosphodiesterase 2 [OS=Homo sapiens]",6,2,2,2,423,47.6,6.98,3.61,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SMPD2","ENSG00000135587","TNF-alpha signaling pathway; S1P receptor signal transduction","Glycosphingolipid metabolism; Ceramide signalling; TNFR1-mediated ceramide production","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",38.9,34.7,35.8,35.8,37.6,44.1,0.931063829787234,-0.10304801865980555,0.39210641536775953,0.40659605202260723,0.5912643667808934,0.22821829346282507,5178]
["High","O60907","F-box-like/WD repeat-containing protein TBL1X [OS=Homo sapiens]",10,4,9,1,577,62.5,6.55,17.27,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1X","ENSG00000101849","Ectoderm differentiation; Ectoderm differentiation; Rett syndrome causing genes","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression","Wnt signaling pathway",80,69.9,83,84.2,81.2,87.1,0.9223762376237624,-0.11657274831565324,0.20439732638219038,0.6895247892861288,0.3969985881572494,0.4012110377119634,4020]
["High","O60911","Cathepsin L2 [OS=Homo sapiens]",8,3,8,2,334,37.3,8.76,14.61,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","CTSV","ENSG00000136943","Endochondral ossification; Endochondral ossification with skeletal dysplasias","MHC class II antigen presentation; Assembly of collagen fibrils and other multimeric structures; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; Trafficking and processing of endosomal TLR; Endosomal/Vacuolar pathway; Activation of Matrix Metalloproteinases","Lysosome; Apoptosis",435.8,475.7,467.2,395.5,399.5,444.1,1.1126624162698733,0.15401594286064263,0.07793850885389458,1.1082479075338376,0.21977026981986597,0.6580310586207766,2769]
["High","O60921","checkpoint protein HUS1 [OS=Homo sapiens]",20,4,12,4,280,31.7,6.84,21.23,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","","HUS1","ENSG00000136273","ATR signaling","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","Cellular senescence",307.3,337.3,300.3,306.5,327.1,332.1,0.9784612198405301,-0.03141342242307354,0.6415287381990784,0.1927838840096656,0.7910701812789647,0.10178498554134847,6332]
["Medium","O60925","prefoldin subunit 1 [OS=Homo sapiens]",6,1,1,1,122,14.2,6.81,2.38,"other biological processes","other cell component","other molecular function","PFDN1","ENSG00000113068","Cellular proteostasis","Prefoldin mediated transfer of substrate  to CCT/TriC","",137.6,152.7,130,173.8,121.4,110.4,1.0362426035502956,0.05136180414863346,0.8242227766666784,0.0839553883021148,0.9056475429515094,0.04304078679678849,7106]
["High","O60927","Protein phosphatase 1 regulatory subunit 11 [OS=Homo sapiens]",12,1,4,1,126,13.9,7.01,8.42,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R11","ENSG00000204619; ENSG00000206501; ENSG00000227720; ENSG00000233314; ENSG00000234058; ENSG00000236560; ENSG00000237403; ENSG00000237829","","","",97,104.7,95.9,117.9,90.8,106.3,0.9447619047619048,-0.08197730216660971,0.5243047260441726,0.2804162275701698,0.7041230307796524,0.1523514503459434,5814]
["High","O60930","Ribonuclease H1 [OS=Homo sapiens]",12,4,7,4,286,32,9.16,13.39,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","RNASEH1","ENSG00000171865","","","DNA replication",365.8,376.8,370.7,321,318.2,345.7,1.1303685653365823,0.17679325112454508,0.010009971729725568,1.9995671490582962,0.06540406633112739,1.1843952496838175,1195]
["High","O60934","Nibrin [OS=Homo sapiens]",9,4,4,4,754,84.9,6.9,2.27,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NBN","ENSG00000104320","miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks","Homologous recombination; Cellular senescence",21.4,13.5,39.2,34.2,13.3,21.3,1.0770348837209303,0.10706497760373594,0.8648618281630459,0.06305327063867851,0.9279704760611601,0.03246584090149483,7277]
["High","O60942-1","mRNA-capping enzyme [OS=Homo sapiens]",19,9,15,9,597,68.5,8.13,31.54,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RNGTT","ENSG00000111880; ENSGGOG00000007863; ENSNLEG00000013064; ENSPPAG00000024828; ENSPTRG00000018413","mRNA processing; Ciliary landscape; mRNA Processing","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA surveillance pathway",648.8,657.2,689,574.6,544.2,567.9,1.1827829489535777,0.2421853507712232,2.5750074225060083E-3,2.589221514759196,0.031366081052928096,1.503539739619378,641]
["High","O75027-1","ATP-binding cassette sub-family B member 7, mitochondrial [OS=Homo sapiens]",22,13,31,13,752,82.6,9.33,70,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","ABCB7","ENSG00000131269","","Mitochondrial ABC transporters; Cytosolic iron-sulfur cluster assembly","ABC transporters",1823.5,1852.5,1930,1967.6,2065.8,2069.5,0.9185796916220158,-0.12252320673464458,0.02287949116431052,1.6405536384012795,0.10428667075944924,0.9817711967081545,1713]
["High","O75037","Kinesin-like protein KIF21B [OS=Homo sapiens]",4,6,6,4,1637,182.5,7.08,15.92,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF21B","ENSG00000116852","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",182.2,196.4,169.8,174.4,188.3,189.4,0.9932983155225504,-0.009701030012712998,0.8984612234952176,0.04650066177755098,0.9468464344784261,0.023720451901325962,7409]
["High","O75044","SLIT-ROBO Rho GTPase-activating protein 2 [OS=Homo sapiens]",28,29,63,26,1071,120.8,6.7,132.98,"","","","","","","","",2325.3,2346.6,2296.7,2382.8,2315.5,2307,0.9947611094457053,-0.007577988927406306,0.6846986597583142,0.16450052222781517,0.8197067058253478,0.08634151203911788,6522]
["High","O75052","Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein [OS=Homo sapiens]",18,7,19,6,506,56.1,6.3,27.08,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","NOS1AP","ENSG00000198929","Sudden infant death syndrome (SIDS) susceptibility pathways","","Circadian entrainment",257.8,277.5,286.5,239.4,258.3,227.8,1.132736044107512,0.1798117162135495,0.05918326765151199,1.2278010600634712,0.18716199020777868,0.727782345336768,2469]
["High","O75054","Immunoglobulin superfamily member 3 [OS=Homo sapiens]",10,10,13,10,1194,135.1,6.07,25.92,"developmental processes","other membranes","","IGSF3","ENSG00000143061","","","",432.1,470.6,472.4,586.8,569.3,551.9,0.8050936768149881,-0.31277143686061226,0.002581122280410305,2.5881914203110394,0.03129410367304916,1.5045374830122162,644]
["High","O75063","Glycosaminoglycan xylosylkinase [OS=Homo sapiens]",20,7,19,7,409,46.4,6.87,40.25,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;nucleus","kinase activity;other molecular function","FAM20B","ENSG00000116199","","","",538.4,601.5,578.8,617.4,629.2,647.6,0.9073487488121634,-0.1402709228807872,0.0458230608114691,1.3389159049079868,0.1597260976856923,0.7966241185835141,2240]
["High","O75064","DENN domain-containing protein 4B [OS=Homo sapiens]",1,1,1,1,1496,163.7,7.21,2.83,"other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","DENND4B","ENSG00000198837","","RAB GEFs exchange GTP for GDP on RABs","",18.1,15.3,17.6,14.1,19.9,24.7,0.8688245315161842,-0.20286325625119386,0.4653016505705285,0.3322654068855998,0.6556714108743343,0.18331375238686823,5541]
["High","O75083","WD repeat-containing protein 1 [OS=Homo sapiens]",52,22,173,22,606,66.2,6.65,467.8,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","WDR1","ENSG00000071127","Hypertrophy model","Platelet degranulation","",6087.7,6333.9,6024.5,5554.3,6032.3,5837.5,1.058654392479382,0.08223168504833547,0.11222548209100258,0.9499085203080204,0.27417289241756826,0.5619754862913388,3196]
["Medium","O75093-1","Slit homolog 1 protein [OS=Homo sapiens]",1,1,2,1,1534,167.8,6.57,0,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","SLIT1","ENSG00000187122","Spinal cord injury","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO","Axon guidance",39.5,47.9,40.3,34.4,36.8,32.3,1.2338164251207733,0.3031277573160366,0.05348749429110479,1.271747746861679,0.17547493925417906,0.7557848992595555,2380]
["High","O75096","Low-density lipoprotein receptor-related protein 4 [OS=Homo sapiens]",6,8,12,8,1905,211.9,5.27,18.09,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LRP4","ENSG00000134569","","ECM proteoglycans","",493.8,466.8,472.4,543.6,502.2,488.9,0.9337329771290808,-0.0989180584958717,0.13938702046824833,0.855777665272883,0.31418413851503546,0.5028157439595566,3464]
["High","O75113","NEDD4-binding protein 1 [OS=Homo sapiens]",27,15,22,15,896,100.3,5.36,44.29,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","N4BP1","ENSG00000102921","","","",482,542.2,491.3,523.6,506.1,496.5,0.9929891233128031,-0.010150179579452911,0.8692111322617163,0.06087472016919056,0.9303359178477699,0.03136021174002553,7295]
["High","O75116","Rho-associated protein kinase 2 [OS=Homo sapiens]",32,43,81,39,1388,160.8,6.02,164.08,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","ROCK2","ENSG00000134318","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; G13 signaling pathway","RHOA GTPase cycle; RHOB GTPase cycle; G alpha (12/13) signalling events; RHOC GTPase cycle; Potential therapeutics for SARS; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; Wnt signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis",3640,2944.2,3684.8,3749.1,3528.4,3583.2,0.9455191654313257,-0.08082139335695766,0.4722303541577099,0.3258461006551988,0.6626841490408697,0.17869341731657223,5564]
["High","O75122","CLIP-associating protein 2 [OS=Homo sapiens]",28,29,69,23,1294,141,8.47,123.98,"","","","","","","","",1639.1,1643,1686.8,2058.8,1866.5,1928.3,0.8488622386223862,-0.23639765628308868,0.007368552014374291,2.132617846462601,0.05479395631260425,1.2612673408739037,1050]
["High","O75127","pentatricopeptide repeat-containing protein 1, mitochondrial [OS=Homo sapiens]",16,10,20,10,700,78.8,8.59,39.44,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity","PTCD1","ENSG00000106246","","","",724.1,766,707.3,786.2,737.6,751.2,{"$f":"AVERAGE(T578:V578)/AVERAGE(W578:Y578)","v":0.9658901098901097},{"$f":"LOG(Z578,2)","v":-0.050069033087943145},{"$f":"TTEST(T578:V578,W578:Y578,2,2)","v":0.31764792707236594},{"$f":"-LOG10(AB578)","v":0.4980539744668284},{"$f":"AB578*7808/AF578","v":0.5182187661055231},{"$f":"-LOG10(AD578)","v":0.2854868640856115},4786]
["High","O75128","Protein cordon-bleu [OS=Homo sapiens]",5,5,6,5,1261,135.5,7.75,9.69,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity","COBL","ENSG00000106078","","","",280.9,267.2,285.3,310.5,306.5,298.5,0.9103222282905514,-0.135550785982151,0.013527852763917377,1.8687711322114826,0.0765401988265702,1.1161104139540836,1380]
["High","O75129","Astrotactin-2 [OS=Homo sapiens]",3,3,4,3,1339,148.1,5.97,2.75,"cell adhesion;transport;developmental processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","ASTN2","ENSG00000148219","","","",206.1,210,227.5,206.7,186.6,182.5,1.1177492184786386,0.16059653716001204,0.08583029033124108,1.066359418419469,0.233019091413884,0.6326084954716784,2876]
["High","O75131","Copine-3 [OS=Homo sapiens]",18,7,16,7,537,60.1,5.85,30.52,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CPNE3","ENSG00000085719","","Neutrophil degranulation; Glycerophospholipid biosynthesis","",533.9,532.9,537.2,548.5,553.1,520.2,0.9890245406338635,-0.015921775913568508,0.5977573027387706,0.22347510944928073,0.7579228677792011,0.12037498935782463,6158]
["High","O75132","Zinc finger BED domain-containing protein 4 [OS=Homo sapiens]",1,1,1,1,1171,130.2,6.83,2.39,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED4","ENSG00000100426","","","",16.1,26.7,21.2,17.4,14.9,18.5,1.2598425196850394,0.3332434081151965,0.2460944739283844,0.6088981383059521,0.4441760639003295,0.35244484875038934,4326]
["High","O75143-1","Autophagy-related protein 13 [OS=Homo sapiens]",22,7,15,7,517,56.5,5.12,28.19,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","ATG13","ENSG00000175224","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease","Macroautophagy","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",591.3,568.3,561.2,603.8,576.7,597.3,0.9679379007762403,-0.047013602259377583,0.19486263083096075,0.7102714383578111,0.38665499911769796,0.41267637039425914,3935]
["High","O75145-1","Liprin-alpha-3 [OS=Homo sapiens]",6,9,9,3,1194,133.4,5.68,19.15,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;other cell component","","PPFIA3","ENSG00000177380","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",330.3,330.3,321.1,382.2,373.2,331.5,0.9032109669702825,-0.14686509117505042,0.09231725787721222,1.034717103955262,0.24318932169543625,0.6140554986039172,2964]
["High","O75146","Huntingtin-interacting protein 1-related protein [OS=Homo sapiens]",20,19,30,18,1068,119.3,6.67,74.35,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","cytoskeletal activity;other molecular function","HIP1R","ENSG00000130787","","Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",1154.9,1110.2,1128.8,1139.8,1135.1,1112.6,1.0018892988929893,2.7231105680182188E-3,0.8968112414442705,0.047298956538622004,0.9458735881665357,0.024166901262188522,7403]
["High","O75147","Obscurin-like protein 1 [OS=Homo sapiens]",9,12,17,12,1896,206.8,5.63,32.06,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","OBSL1","ENSG00000124006","","Neddylation","",631.5,661.3,634,785.7,812.1,839.9,0.7904171965377199,-0.3393137599462908,0.000746475538398049,3.1269844193023957,0.01880155162519989,1.7258063084780328,310]
["High","O75150","E3 ubiquitin-protein ligase BRE1B [OS=Homo sapiens]",39,39,91,37,1001,113.6,6.23,233.37,"protein metabolism;other metabolic processes","nucleus","other molecular function","RNF40","","","","",3658.2,3483.5,3663.5,3661.4,3758,3668.7,0.974486160839098,-0.03728639768595595,0.2308604275836366,0.6366505043064472,0.42633827307782274,0.3702456782832005,4228]
["High","O75152","Zinc finger CCCH domain-containing protein 11A [OS=Homo sapiens]",36,27,85,27,810,89.1,8.37,174.52,"other metabolic processes;transport","nucleus","nucleic acid binding activity;other molecular function","ZC3H11A","ENSG00000058673","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",4273.6,4354.1,4316.7,4840.2,4608.1,4605.4,0.921067049958374,-0.11862191238021969,0.010397374618204815,1.9830763080825382,0.06698242658328646,1.1740391232541703,1212]
["High","O75153","Clustered mitochondria protein homolog [OS=Homo sapiens]",31,32,66,32,1309,146.6,6.13,126.38,"cell organization and biogenesis","other cell component","nucleic acid binding activity","CLUH","ENSG00000132361","Translation factors","","",2359.5,2254.3,2279,2184.4,2179.1,2222,1.0466631235289652,0.06579717462901709,0.041224568832748935,1.3848438779402574,0.14978196065430605,0.8245404887730654,2149]
["High","O75154","Rab11 family-interacting protein 3 [OS=Homo sapiens]",3,2,2,1,756,82.4,4.51,2.62,"cell cycle OR cell proliferation;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RAB11FIP3","ENSG00000090565; ENSG00000275338","","VxPx cargo-targeting to cilium","Endocytosis",29,30.8,30.9,29.9,32.4,27.8,1.0066592674805772,0.009575444714983965,0.8980692915260089,0.04669015357052195,0.9466889467038042,0.023792693563481238,7407]
["High","O75157","TSC22 domain family protein 2 [OS=Homo sapiens]",8,6,17,5,780,79.2,5.02,28.74,"stress response;other biological processes","","","TSC22D2","ENSG00000196428","","","",795,780.8,815.5,765.1,632.9,689.1,1.1457524795170333,0.19629540784450314,0.06262909926633511,1.203223834290602,0.1939738227177884,0.7122568753084126,2521]
["High","O75164-1","Lysine-specific demethylase 4A [OS=Homo sapiens]",16,13,28,13,1064,120.6,5.85,65.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","KDM4A","ENSG00000066135","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","",1159.3,1049.8,1227.3,1092.7,1154.5,1174.7,1.0042374119641135,6.1003774294151256E-3,0.936815450170982,0.028345955394413553,0.9679310619207393,0.014155572953553658,7557]
["High","O75165","DnaJ homolog subfamily C member 13 [OS=Homo sapiens]",14,25,39,25,2243,254.3,6.74,89.93,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","DNAJC13","ENSG00000138246","","Neutrophil degranulation","",1509.2,1578.5,1511.2,1419.7,1567.1,1480.7,1.0294124230553998,0.0418210983548422,0.4170815221244228,0.379779050185718,0.6146796007450912,0.2113511994882948,5298]
["High","O75167","Phosphatase and actin regulator 2 [OS=Homo sapiens]",4,2,3,2,634,69.7,8.16,6.72,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","enzyme regulator activity;cytoskeletal activity","PHACTR2","ENSG00000112419","","Platelet degranulation","",151,152.9,160.6,149.5,139.1,146.6,1.0673253676470587,0.09400004001967562,0.08400833434763344,1.0756776260615022,0.2301533595039726,0.6379826814113769,2850]
["High","O75170","Serine/threonine-protein phosphatase 6 regulatory subunit 2 [OS=Homo sapiens]",7,4,5,4,966,104.9,4.87,2.06,"other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP6R2","ENSG00000100239","","","",86.5,90.1,94.9,76,57.9,82.2,1.2563627950023135,0.3292531258322164,0.07412197604919148,1.1300530111580465,0.2133226645750413,0.6709630002610072,2713]
["High","O75175","CCR4-NOT transcription complex subunit 3 [OS=Homo sapiens]",16,9,19,9,753,81.8,6.2,32.73,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","","CNOT3","ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615","","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",834.9,769.6,770.2,909,850.1,873.3,0.9021045433824647,-0.14863346020967833,0.035873251000374425,1.4452292637604631,0.13757286041793884,0.8614672327665489,2036]
["High","O75177","Calcium-responsive transactivator [OS=Homo sapiens]",9,2,2,2,396,43,6.44,2.63,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SS18L1","ENSG00000184402","","","",77.6,88.4,78.3,96.3,79.9,100.5,0.8829056740151789,-0.1796687803426982,0.20740287718517422,0.6831852231785236,0.4006436578579516,0.3972417276991734,4042]
["High","O75179-1","Ankyrin repeat domain-containing protein 17 [OS=Homo sapiens]",18,36,76,24,2603,274.1,6.52,163.5,"stress response;developmental processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","ANKRD17","ENSG00000132466","","","",2464.8,2433.1,2515.5,2499.4,2503.4,2442,0.9957822909950569,-0.006097736162239582,0.7536162316155641,0.12284975614782723,0.8646929517199595,0.06313808102854533,6805]
["High","O75182-2","Isoform 2 of Paired amphipathic helix protein Sin3b [OS=Homo sapiens]",13,10,15,9,1130,129.3,6.98,26.54,"","","","SIN3B","","","","",277.9,301.2,295.8,314.8,309,297.4,0.9497394702561874,-0.07439628304143657,0.15085868582581805,0.8214296798699847,0.3316172913648613,0.4793628323179127,3552]
["High","O75190","DnaJ homolog subfamily B member 6 [OS=Homo sapiens]",36,12,36,11,326,36.1,9.16,88.88,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNAJB6","ENSG00000105993","","Regulation of HSF1-mediated heat shock response","",1549.3,1629.3,1640.1,1579.2,1543.3,1514.1,1.0392744683604365,0.05557671473323215,0.1512297806781966,0.8203626776796402,0.33205909098294684,0.4787846253191809,3556]
["High","O75191","xylulose kinase [OS=Homo sapiens]",7,3,3,3,536,58.3,5.86,8.4,"other metabolic processes","cytosol","kinase activity;other molecular function","XYLB","ENSG00000093217","","Formation of xylulose-5-phosphate","Pentose and glucuronate interconversions; Metabolic pathways",170.2,163.1,144.7,140.8,159.3,172.7,1.0109983079526226,0.01578058269057832,0.8918583500329484,0.049704117242817904,0.9429424505155398,0.025514812232150793,7385]
["High","O75208-1","Ubiquinone biosynthesis protein COQ9, mitochondrial [OS=Homo sapiens]",9,2,4,2,318,35.5,5.94,15.33,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ9","ENSG00000088682","","Ubiquinol biosynthesis","",104.3,85.6,98.6,112.3,106.3,101.8,0.9004369538077404,-0.15130282887586524,0.16746858194173994,0.7760666570997633,0.3522614999464185,0.45313481998795235,3712]
["High","O75223-1","gamma-glutamylcyclotransferase [OS=Homo sapiens]",59,10,47,10,188,21,5.14,103.14,"cell organization and biogenesis;signal transduction","cytosol","other molecular function","C7orf24; GGCT","ENSG00000006625; ENSGGOG00000024930; ENSPPAG00000031715; ENSPTRG00000019041","Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases","Glutathione synthesis and recycling","Glutathione metabolism; Metabolic pathways",1971.3,2044.2,2068.4,2039.2,2102.4,2148.6,0.9672029506216017,-0.04810944910030607,0.1857685935541307,0.7310277069142097,0.3752862040027561,0.42563740050991805,3865]
["High","O75251","NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [OS=Homo sapiens]",14,3,12,3,213,23.5,9.99,24.45,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cell component","transporter activity;other molecular function","NDUFS7","ENSG00000115286","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",372.4,441.1,431.7,423.7,442.5,449.1,0.9467041739527102,-0.07901441200848033,0.36358231412865266,0.4393972504862161,0.5651703580960621,0.24782062398712998,5023]
["High","O75290-1","Zinc finger protein 780A [OS=Homo sapiens]",3,1,1,1,641,74.5,8.65,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF780A","ENSG00000197782; ENSG00000280568","","","Herpes simplex virus 1 infection",259.2,224.8,212.4,260.7,255.7,282.2,0.8720260455797646,-0.19755686898194685,0.10313359286451003,0.9865998524718654,0.26026732161800076,0.5845803571765787,3094]
["High","O75306-1","NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [OS=Homo sapiens]",29,10,26,10,463,52.5,7.55,62.3,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS2","ENSG00000158864","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",1008.9,1078.4,922,962.7,1052.5,1022.3,0.9907160493827161,-0.013456471226961966,0.8662822109915098,0.06234060369813,0.9288562899507977,0.032051473637419545,7282]
["High","O75312","Zinc finger protein ZPR1 [OS=Homo sapiens]",28,12,22,12,459,50.9,4.73,52.98,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ZPR1","ENSG00000109917","","","",1548.4,1517.3,1586.8,1512.1,1445.2,1462.7,1.0526018099547512,0.07395978066771998,0.05238264431478869,1.2808125818494212,0.17389612534433252,0.7597100945948866,2352]
["High","O75323-1","Protein NipSnap homolog 2 [OS=Homo sapiens]",23,6,14,5,286,33.7,9.36,26.19,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;mitochondrion","","NIPSNAP2","ENSG00000146729","","RHOJ GTPase cycle; RHOH GTPase cycle","",431.8,420.9,473.2,449.4,451.3,436.4,0.9916236631515968,-0.012135395967637847,0.8331222460630581,0.07929126882687475,0.910939433869256,0.04051049724300812,7141]
["High","O75326-1","Semaphorin-7A [OS=Homo sapiens]",11,5,9,5,666,74.8,7.64,24.53,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding","SEMA7A","ENSG00000138623; ENSG00000288455","","Other semaphorin interactions","Axon guidance",273.9,287.1,261.7,191.6,190.9,203.9,1.4029672578444747,0.4884813400364985,7.414029224103979E-4,3.129945706431343,0.018734220123561122,1.727364381197542,309]
["High","O75330-1","Hyaluronan mediated motility receptor [OS=Homo sapiens]",38,27,58,26,724,84,5.83,119.76,"","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","HMMR","ENSG00000072571","","AURKA Activation by TPX2; Hyaluronan uptake and degradation","ECM-receptor interaction",2837.9,2379.5,2816.4,2147.1,1961.1,2005,1.3141726100896418,0.39415477898261625,0.01596170749278123,1.7969206521439542,0.08420879196191612,1.074642562880276,1480]
["High","O75340","programmed cell death protein 6 [OS=Homo sapiens]",41,6,10,1,191,21.9,5.4,17.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PDCD6","ENSG00000249915","Epithelial to mesenchymal transition in colorectal cancer","","",230.6,206.4,199.9,190.9,198.9,180.9,1.1159978973190816,0.15833430895008324,0.10801962996290816,0.9664973147917476,0.268006759056367,0.5718542530463324,3147]
["High","O75340-2","Isoform 2 of Programmed cell death protein 6 [OS=Homo sapiens]",40,6,9,1,189,21.7,5.4,15.25,"","","","PDCD6","","","","",506,554,468.9,531,558,546.5,0.9348211556099054,-0.09723771127139634,0.24117017192420442,0.6176764070201972,0.4385320685571002,0.35799864246179164,4294]
["High","O75347","Tubulin-specific chaperone A [OS=Homo sapiens]",44,5,7,5,108,12.8,5.29,8.45,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TBCA","ENSG00000171530","VEGFA-VEGFR2 signaling pathway","Post-chaperonin tubulin folding pathway","",336.1,387.9,334.7,353.2,305.9,257.8,1.1546515432435385,0.2074575333009571,0.22106327684117444,0.6554833966789223,0.41571822388629337,0.38120093686068834,4152]
["High","O75351","Vacuolar protein sorting-associated protein 4B [OS=Homo sapiens]",38,14,32,11,444,49.3,7.23,58.84,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS4B","ENSG00000119541","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)","Endocytosis; Necroptosis",1136.9,1138.2,1095.3,1263.6,1177.3,1179.1,0.9310497237569064,-0.10306987629567518,0.058853560219841304,1.2302272603130875,0.18649699602131528,0.72932815914684,2464]
["High","O75352","Mannose-P-dolichol utilization defect 1 protein [OS=Homo sapiens]",10,2,10,2,247,26.6,8.94,17.33,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","","MPDU1","ENSG00000129255","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective MPDU1 causes CDG-1f","",292.6,314.8,295.9,256,335.2,293.3,1.0212549462973433,0.030343065868013108,0.8061021231048331,0.09360993500459465,0.8940405365344513,0.048642789488071464,7040]
["High","O75362","zinc finger protein 217 [OS=Homo sapiens]",13,11,16,10,1048,115.2,8.48,31,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","ZNF217","ENSG00000171940","","Estrogen-dependent gene expression","",745.4,667.7,793.7,951.2,909.5,899.3,0.7995652173913044,-0.32271238141979985,0.009945296146922685,2.0023822801052154,0.06525451455056498,1.1853894368391107,1190]
["High","O75367-1","Core histone macro-H2A.1 [OS=Homo sapiens]",42,14,65,12,372,39.6,9.79,178.74,"cell organization and biogenesis;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","H2afy; H2AFY; LOC100466888; LOC101338325; LOC101381952; LOC101564704; LOC102987354; LOC103079324; LOC103663804; LOC106989149; LOC109250833; LOC110591142; LOC111141291; LOC111182462; LOC112404331; LOC112815157; LOC112861289; LOC112917035; LOC113261754; LOC113928700; LOC115516119; LOC116529369; MACROH2A1","ENSAMEG00000017887; ENSCAFG00000001076; ENSCANG00000022762; ENSCJAG00000005818; ENSFCAG00000013924; ENSG00000113648; ENSGGOG00000001707; ENSLCNG00005003680; ENSMLEG00000037795; ENSMNEG00000031666; ENSMPUG00000010011; ENSPCOG00000013464; ENSPCTG00005011747; ENSPPAG00000029258; ENSPTRG00000017256; ENSRBIG00000034425; ENSRROG00000045755; ENSSBOG00000034640; ENSSSUG00005001976; ENSVVUG00000017487","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma","","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus",4023.2,4248,4026.3,4091.9,4382.4,4364.6,0.9578312783805467,-0.06215654673493168,0.20673972242466623,0.6845760711596913,0.39985725853153187,0.39809501591137025,4037]
["High","O75368","SH3 domain-binding glutamic acid-rich-like protein [OS=Homo sapiens]",89,8,27,8,114,12.8,5.25,54.5,"","nucleus;other cell component","other molecular function","SH3BGRL","ENSG00000131171","","","",906.6,846.2,868.3,1126.6,918.7,945.1,0.8765048154093099,-0.19016607789222634,0.14309430367837653,0.8443776543624312,0.31967963465544036,0.49528502978549593,3495]
["High","O75369-1","Filamin-B [OS=Homo sapiens]",69,132,616,1,2602,278,5.73,1319.52,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLNB","ENSG00000136068","Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host","ISG15 antiviral mechanism","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer",16.5,15.3,17,18.2,9.1,15.3,1.1455399061032865,0.19602771733704819,0.4913137094439548,0.30864111729650223,0.6788493086778268,0.16822661993576513,5651]
["High","O75369-8","Isoform 8 of Filamin-B [OS=Homo sapiens]",68,132,613,1,2633,281.5,5.71,1316.89,"","","","FLNB","","","","",20349,20045.5,20763,20466.8,19360.4,20101.6,1.0205026631602836,0.029279947312445858,0.34874210706498493,0.45749561281343826,0.5507642338113679,0.25903427023556225,4944]
["High","O75376-1","Nuclear receptor corepressor 1 [OS=Homo sapiens]",5,12,14,11,2440,270,7.11,29.93,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NCOR1","ENSG00000141027","Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome causing genes; 22q11.2 copy number variation syndrome; Notch signaling pathway","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis","Endocrine resistance; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer",798,684,780.5,903.2,812,783.3,0.9055433259955973,-0.14314442587795792,0.19517046081663572,0.7095859124639103,0.3870690774844531,0.4122115225955045,3937]
["High","O75379-1","Vesicle-associated membrane protein 4 [OS=Homo sapiens]",33,3,6,3,141,16.4,7.34,9.78,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP4","ENSCATG00000035773; ENSG00000117533; ENSGGOG00000023200; ENSMFAG00000031870; ENSMLEG00000033096; ENSMMUG00000023203; ENSMNEG00000025169; ENSNLEG00000015204; ENSPANG00000022546; ENSPPAG00000028975; ENSPTRG00000001680; ENSRBIG00000031656; ENSRROG00000036404","","Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network","SNARE interactions in vesicular transport",121.5,102.1,118.1,156.9,107.5,137.8,0.8495773247140725,-0.23518283387608396,0.2651030063115021,0.576585347268441,0.46421266501013864,0.3332830149594129,4459]
["High","O75380","NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [OS=Homo sapiens]",39,3,4,3,124,13.7,8.28,14.64,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS6","ENSG00000145494","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",186.1,175.6,167.5,206,177.3,186.3,0.9290730337078652,-0.10613608468772094,0.25093465317869296,0.6004393600282149,0.4491741797384765,0.34758521661226094,4362]
["High","O75381-1","Peroxisomal membrane protein PEX14 [OS=Homo sapiens]",24,8,20,8,377,41.2,4.94,58.29,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PEX14","ENSG00000142655; ENSMFAG00000032533; ENSMMUG00000019979; ENSPANG00000017539; ENSPPAG00000038193; ENSPTRG00000000132","","Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Class I peroxisomal membrane protein import","Peroxisome",1187.3,1121.7,1153.7,1270.8,1236.6,1210,0.9314843707967936,-0.10239653222943894,0.0303851691366751,1.5173383418435615,0.12395370983237157,0.9067404706257509,1914]
["High","O75382-1","Tripartite motif-containing protein 3 [OS=Homo sapiens]",4,3,6,1,744,80.8,7.83,14.47,"protein metabolism;other metabolic processes;transport;developmental processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TRIM3","ENSG00000110171; ENSPTRG00000003290","","Interferon gamma signaling","",64.4,57.9,69.7,62.9,52.6,60.4,1.091529277998863,0.12635082813655757,0.3091925417133952,0.5097709906003589,0.509427171491494,0.2929178946411246,4739]
["High","O75385","Serine/threonine-protein kinase ULK1 [OS=Homo sapiens]",3,2,2,2,1050,112.6,8.79,3.78,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","ULK1","ENSG00000177169","Target of rapamycin (TOR) signaling; Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; p53 transcriptional gene network; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease","RAB GEFs exchange GTP for GDP on RABs; Macroautophagy; TBC/RABGAPs; Receptor Mediated Mitophagy","Mitophagy; Autophagy; mTOR signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",20.7,21.9,17.3,15.5,22.2,19.5,1.047202797202797,0.06654085601039607,0.7250141397179628,0.13965352344058496,0.846807838880756,0.07221513037995272,6685]
["Medium","O75386","Tubby-related protein 3 [OS=Homo sapiens]",2,1,2,1,442,49.6,7.74,3.95,"developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TULP3","ENSG00000078246","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Genes related to primary cilium development (based on CRISPR)","Hedgehog 'off' state","",119.2,134.7,122.4,152.7,141.8,143.6,0.8589363159096096,-0.2193769252550695,0.02383186292952859,1.6228420076580916,0.10657456228737641,0.9723464423690071,1746]
["High","O75390","citrate synthase, mitochondrial [OS=Homo sapiens]",39,16,87,16,466,51.7,8.32,160.5,"other metabolic processes","mitochondrion","other molecular function","CS","ENSG00000062485","TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)","Mitochondrial protein import; Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids",4892.6,5262.3,4961.8,4728.7,4911.8,5064.5,1.0279972798367902,0.03983644705011283,0.41009158842574905,0.38711913863191605,0.6075892072918878,0.2163899491858272,5270]
["High","O75391","Sperm-associated antigen 7 [OS=Homo sapiens]",20,3,4,3,227,26,7.91,9.82,"","nucleus","nucleic acid binding activity","SPAG7","ENSG00000091640","","","",82.1,84.9,73.4,102.5,73.7,72.7,0.9658497388509444,-0.050129334269849994,0.79813669390071,0.0979227222797821,0.8888676802134851,0.05116288473303601,7011]
["High","O75396","Vesicle-trafficking protein SEC22b [OS=Homo sapiens]",38,8,52,8,215,24.6,6.92,131.89,"","","","","","","","",1304.5,1348.8,1325,1394.1,1381.6,1388.4,0.9553805143968684,-0.06585264247601064,0.009614368772175644,2.01707922393304,0.06388850329629568,1.1945772858821597,1175]
["High","O75400","pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",34,34,103,1,957,108.7,7.56,201.48,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","PRPF40A","ENSG00000196504","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",163.9,169.3,190,187.9,188.6,185.7,0.9306296691568837,-0.1037209128822604,0.17957707588534308,0.7457491044834778,0.36782209037585484,0.43436219179113117,3812]
["High","O75400-3","Isoform 3 of Pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",34,34,102,1,939,106.8,7.43,195.17,"","","","PRPF40A","","","","",5293.8,4871.7,5613.6,5290.3,4792.3,5087.8,1.040124189210568,0.0567557941948795,0.4771341908644753,0.3213594613037168,0.6660940036241414,0.17646447597332962,5593]
["High","O75410-1","Transforming acidic coiled-coil-containing protein 1 [OS=Homo sapiens]",27,16,31,13,805,87.7,4.88,72.42,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TACC1","ENSG00000147526","","","",1538.8,1421,1556.3,1393.3,1338.3,1362.2,1.1031559919878842,0.1416368099275271,0.03612969475896868,1.4421357075450565,0.13828463562648405,0.8592260703123199,2040]
["High","O75414","Nucleoside diphosphate kinase 6 [OS=Homo sapiens]",10,2,4,2,186,21.1,8.32,11.3,"other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","NME6","ENSG00000172113","Pyrimidine metabolism","","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",101.1,110.9,103.3,126.7,112.8,118.1,0.8817114093959733,-0.181621566499983,0.04842234780632394,1.3149541571782275,0.16517330348264628,0.7820601451941351,2289]
["High","O75420","GRB10-interacting GYF protein 1 [OS=Homo sapiens]",20,17,26,17,1035,114.5,5.39,41.2,"signal transduction","cytosol;other cell component","","GIGYF1","ENSG00000146830","","","",730,674.2,776.7,971.6,836.5,850.3,0.820380680108336,-0.28563457800876313,0.03795478045581944,1.4207335163473556,0.14254493785427522,0.8460482010201893,2079]
["High","O75427","Leucine-rich repeat and calponin homology domain-containing protein 4 [OS=Homo sapiens]",33,15,22,15,683,73.4,8.22,37.93,"developmental processes","nucleus","","LRCH4","ENSG00000077454","","","",361.8,356.7,385.2,308.8,274,280.8,1.2780222325150536,0.35391293367162585,4.39407846180896E-3,2.3571321924709387,0.04094148523843002,1.38783640644258,838]
["High","O75431","Metaxin-2 [OS=Homo sapiens]",32,7,28,7,263,29.7,6.29,81.16,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus;other cell component","","MTX2","ENSG00000128654","","Mitochondrial protein import; Cristae formation","",947.7,941.8,968.9,948.4,965.7,1009.4,0.9777321703437661,-0.0324887722811382,0.33741227156782544,0.4718391263192879,0.5388658245861282,0.2685193589244882,4889]
["High","O75436-1","Vacuolar protein sorting-associated protein 26A [OS=Homo sapiens]",30,9,24,8,327,38.1,6.57,44.85,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26A","ENSANAG00000022406; ENSCATG00000037809; ENSCCAG00000021117; ENSCJAG00000012907; ENSCSAG00000007798; ENSG00000122958; ENSMFAG00000042937; ENSMMUG00000004101; ENSMNEG00000039163; ENSNLEG00000011548; ENSPANG00000022152; ENSPPAG00000041182; ENSPPYG00000002386; ENSPTRG00000002567; ENSRBIG00000023684; ENSRROG00000006745; ENSSBOG00000030031","","WNT ligand biogenesis and trafficking","Endocytosis",615.3,683.5,582,550.3,723.1,606.6,1.0004255319148936,6.1378220065924237E-4,0.9966103505334749,1.4746066730594721E-3,0.999041419561609,4.1650585394407242E-4,7789]
["Medium","O75438","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [OS=Homo sapiens]",19,1,1,1,58,7,8.92,2.39,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB1","ENSG00000183648","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",37.7,47.2,35.6,38.3,44.1,33.3,1.041486603284356,0.05864428200983384,0.7526948849677196,0.12338103525819695,0.8640167100599757,0.06347785819626488,6802]
["High","O75439","mitochondrial-processing peptidase subunit beta [OS=Homo sapiens]",36,14,45,13,489,54.3,6.83,111.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;mitochondrion","other molecular function","PMPCB","ENSG00000105819","","Mitochondrial protein import; Processing of SMDT1","",1940.4,1965.4,2001.5,1894.6,1923.5,1983.9,1.0181489141675286,0.02594858500810062,0.33065138603746963,0.4806296524635134,0.5323146437485696,0.2738315864071417,4850]
["High","O75448","Mediator of RNA polymerase II transcription subunit 24 [OS=Homo sapiens]",20,15,19,15,989,110.2,6.95,36.25,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED24","ENSG00000008838","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",779.8,780,751.5,838.1,795.1,801.8,0.949199178644764,-0.07521724273902275,0.0654593414996872,1.1840283678714398,0.19825699706344363,0.7027714762301887,2578]
["High","O75449-1","Katanin p60 ATPase-containing subunit A1 [OS=Homo sapiens]",31,13,18,12,491,55.9,6.9,33.94,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNA1","ENSG00000186625","","","",438.4,431.9,429.3,458.5,430.5,420.5,{"$f":"AVERAGE(T642:V642)/AVERAGE(W642:Y642)","v":0.9924398625429554},{"$f":"LOG(Z642,2)","v":-0.010948410908475183},{"$f":"TTEST(T642:V642,W642:Y642,2,2)","v":0.7917239525122277},{"$f":"-LOG10(AB642)","v":0.10142621588316161},{"$f":"AB642*7808/AF642","v":0.8848812798762488},{"$f":"-LOG10(AD642)","v":0.05311499252615417},6986]
["High","O75461-1","transcription factor E2F6 [OS=Homo sapiens]",15,3,5,3,281,31.8,5.5,8.22,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F6","ENSG00000169016; ENSPPAG00000036538; ENSPTRG00000011661","G1 to S cell cycle control; Cell cycle","Transcriptional Regulation by E2F6; G1/S-Specific Transcription","",89.1,85.6,72.8,98,101.7,96.7,0.8350202429149798,-0.2601169224514995,0.03453383003557554,1.4617552527807685,0.13401597659929115,0.8728434245060228,2012]
["High","O75475-1","PC4 and SFRS1-interacting protein [OS=Homo sapiens]",65,40,255,39,530,60.1,9.13,511.39,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSIP1","ENSG00000164985; ENSGGOG00000016152; ENSPTRG00000020786","MECP2 and associated Rett syndrome","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection","",13847.2,12467,14672,15015.9,13547.4,14612.1,0.9492952005076963,-0.07507130576169088,0.40147254994032616,0.39634414357829867,0.6000569812278076,0.22180750718668074,5224]
["High","O75477","erlin-1 [OS=Homo sapiens]",27,10,41,7,346,38.9,7.87,78.23,"","","","","","","","",436.4,467.5,422.8,478.6,504.7,460.3,0.9190218897201441,-0.12182887013627453,0.10246603429453639,0.9894200718087742,0.25916903005239394,0.5864168966322342,3087]
["High","O75478","Transcriptional adapter 2-alpha [OS=Homo sapiens]",5,2,3,2,443,51.5,6.89,4.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TADA2A","ENSG00000277104","","HATs acetylate histones","",42.3,49.6,37.1,50,63.1,47,0.8057464084946908,-0.3116022422056405,0.16607529202183707,0.7796949752352857,0.35074814176535135,0.45500462114975715,3697]
["High","O75487","Glypican-4 [OS=Homo sapiens]",8,3,5,2,556,62.4,6.68,10.26,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC4","ENSG00000076716","Wnt signaling","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Wnt signaling pathway",132.8,157.6,137.9,153,165.5,155.7,0.9032053985660058,-0.14687398559096576,0.14484877773067584,0.8390851651275476,0.3217579677158227,0.492470689824755,3515]
["High","O75489","NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [OS=Homo sapiens]",54,15,51,15,264,30.2,7.5,109.18,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS3","ENSG00000213619; ENSG00000285387","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","RHOG GTPase cycle; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",2069.7,2093.1,2121.9,2482.4,2378.3,2422.7,0.862879973638685,-0.21276820000113933,0.000591035467192573,3.228386456946407,0.01768124493425138,1.7524871596260523,261]
["High","O75494-1","Serine/arginine-rich splicing factor 10 [OS=Homo sapiens]",31,12,42,9,262,31.3,11.27,92.81,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Srsf10; SRSF10","ENSCATG00000031598; ENSCCAG00000022497; ENSCPOG00000034102; ENSG00000188529; ENSGGOG00000000392; ENSMLEG00000016013; ENSMNEG00000041500; ENSMUSG00000028676; ENSNLEG00000027520; ENSPANG00000021680; ENSPCOG00000022379; ENSPCTG00005007467; ENSPPAG00000032557; ENSPPYG00000001726; ENSPTRG00000044753; ENSRBIG00000028456; ENSRFEG00010001865; ENSRROG00000043248; ENSSBOG00000019550; ENSSSCG00070027414; ENSSTOG00000000956; ENSTSYG00000009439","mRNA processing; mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","Spliceosome",2334.6,2281.9,2346.5,2894.9,2512.4,2743.1,0.8543138987043581,-0.22716184132119366,0.024805909962428645,1.6054448369844598,0.10948815431692643,0.9606328652355475,1769]
["High","O75496","Geminin [OS=Homo sapiens]",13,2,2,2,209,23.6,4.96,2.77,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","GMNN","ENSG00000112312","DNA replication","CDT1 association with the CDC6:ORC:origin complex; Activation of the pre-replicative complex","",194.8,192.8,184,261.4,167.4,150.5,0.9867080959779044,-0.019304748575989936,0.9445172018153316,0.024790128175765404,0.9724143343584004,0.012148647847139874,7584]
["High","O75503","Ceroid-lipofuscinosis neuronal protein 5 [OS=Homo sapiens]",10,2,2,2,358,41.5,7.4,5.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLN5","ENSG00000102805","","","Lysosome",12,15.3,18.6,16.7,20.6,21.1,0.7859589041095892,-0.34747421546620894,0.1520849372395975,0.8179137971084992,0.333374281293312,0.47706790757708856,3562]
["High","O75506","Heat shock factor-binding protein 1 [OS=Homo sapiens]",42,3,4,3,76,8.5,4.36,11.36,"stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","HSBP1","ENSG00000230989","","HSF1 activation; Attenuation phase","",322.8,341.9,284.5,290,241.7,230.8,1.2448524590163936,0.3159747629689749,0.06619563877570268,1.179170622615272,0.19955812647130755,0.6999305820378885,2590]
["High","O75509","Tumor necrosis factor receptor superfamily member 21 [OS=Homo sapiens]",4,2,2,2,655,71.8,7.83,4.16,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","","TNFRSF21","ENSG00000146072","Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer","PPARA activates gene expression","Cytokine-cytokine receptor interaction",35.5,45.1,34.8,39.3,31.1,45.6,0.9948275862068965,-0.007481581369452083,0.9719901947277227,0.01233811614072376,0.9857513236048914,6.2326311110266885E-3,7699]
["High","O75521","Enoyl-CoA delta isomerase 2, mitochondrial [OS=Homo sapiens]",28,6,15,6,394,43.6,9,42.82,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ECI2","ENSG00000198721","","","Fatty acid degradation; Peroxisome",363.1,318.6,373.9,396.2,378.3,403.7,0.8959429638431504,-0.15852120233635653,0.09202573317676538,1.0360907138068047,0.24274896102844057,0.6148426202071078,2960]
["High","O75525-1","KH domain-containing, RNA-binding, signal transduction-associated protein 3 [OS=Homo sapiens]",10,4,18,2,346,38.8,7.61,29.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHDRBS3","ENSCCAG00000031191; ENSG00000131773; ENSGGOG00000000940; ENSRBIG00000036854; ENSRROG00000044792","","PTK6 Regulates Proteins Involved in RNA Processing","",95.6,107.9,91.8,95.1,93.8,80.3,1.0969539375928679,0.13350294652363728,0.2688472814168623,0.5704943507495353,0.46824884526050875,0.3295232849566918,4483]
["High","O75529-1","TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L [OS=Homo sapiens]",12,4,4,4,589,66.1,5.88,7.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","TAF5L","ENSG00000135801; ENSGGOG00000028544; ENSPPAG00000034307; ENSPTRG00000002091","","HATs acetylate histones","Basal transcription factors",135.2,123.5,131.1,112.8,121.6,117.1,1.1089615931721193,0.1492094012979921,0.040243812279739756,1.3953008854662357,0.14717737062304825,0.8321589601686428,2135]
["High","O75530","Polycomb protein EED [OS=Homo sapiens]",20,7,11,7,441,50.2,7.03,18.24,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","EED","ENSG00000074266","Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma","Transcriptional Regulation by E2F6; HCMV Early Events; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis","",503.7,507.6,472.8,551.3,597.6,603.7,0.8467990414241697,-0.2399084586705556,0.010789825148306318,1.9669855931058755,0.06843781864985843,1.1647038413785564,1231]
["High","O75531","Barrier-to-autointegration factor [OS=Homo sapiens]",25,3,5,3,89,10.1,6.09,2.34,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BANF1","ENSG00000175334","Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation","",108.9,178.6,149.9,172,118.7,131.5,1.0360018948365703,0.05102664170093732,0.8540419157251742,0.06852081394632598,0.9223180190846695,0.03511930658222138,7230]
["High","O75533-1","splicing factor 3B subunit 1 [OS=Homo sapiens]",49,55,274,55,1304,145.7,7.09,581.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101357717; LOC111145177; Sf3b1; SF3B1","ENSANAG00000021577; ENSCANG00000029415; ENSCATG00000035735; ENSCCAG00000020506; ENSCGRG00001016990; ENSCGRG00015028775; ENSCJAG00000003902; ENSCSAG00000011505; ENSDLEG00000016863; ENSFCAG00000005038; ENSG00000115524; ENSLAFG00000001956; ENSLCNG00005009987; ENSMMNG00015005194; ENSMMUG00000022430; ENSMNEG00000042333; ENSMPUG00000007799; ENSMUSG00000025982; ENSNLEG00000006861; ENSPANG00000013417; ENSPCTG00005000567; ENSPPAG00000035007; ENSRNOG00000013516; ENSRROG00000031308; ENSSBOG00000020080; ENSSSCG00000016075; ENSSSCG00070023758; ENSSSUG00005005995; ENSSTOG00000011034; ENSUMAG00000020945","mRNA processing; mRNA processing; mRNA processing","B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway","Spliceosome",13353.4,12256.1,13294,14551.2,14815.7,14641.3,0.8840057080271405,-0.17787240975497415,9.543710462762282E-3,2.0202827447706615,0.06374447501560983,1.1955574512738663,1169]
["High","O75534","cold shock domain-containing protein E1 [OS=Homo sapiens]",47,39,211,39,798,88.8,6.25,409.73,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity","CSDE1","ENSG00000009307","","","",9748.1,10056.5,9916.1,9453,10213.1,10086.7,0.9989211099459546,-1.5573495862702847E-3,0.9681008306631058,0.014079407236985827,0.9841077054833394,0.006957367689286552,7681]
["Low","O75541","zinc finger protein 821 [OS=Homo sapiens]",2,1,1,1,412,46.8,6.55,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF821","ENSG00000102984","","","",14.8,11.4,16.2,12.4,20,8.6,1.0341463414634147,0.04844035505775318,0.9042192985342996,0.04372622816047811,0.9500934306225018,0.02223368480734214,7431]
["High","O75553-5","Isoform DAB553 of Disabled homolog 1 [OS=Homo sapiens]",17,6,6,6,553,59.6,5.36,7.81,"","","","DAB1","","","","",189.5,203.8,190.1,177.7,186.1,200.5,1.0338472443735602,0.04802303665382646,0.4774285960761428,0.3210915720361399,0.6662667521291373,0.17635185824187333,5595]
["High","O75554","WW domain-binding protein 4 [OS=Homo sapiens]",18,5,7,5,376,42.5,5.57,13.15,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","WBP4","ENSG00000120688","","mRNA Splicing - Major Pathway","",375.1,341.5,387.5,364.8,311.3,339,1.0876760910255145,0.12124898724512295,0.224628825776104,0.6485345131136796,0.42019690264969334,0.3765471531844794,4174]
["High","O75569-1","Interferon-inducible double-stranded RNA-dependent protein kinase activator A [OS=Homo sapiens]",30,9,38,9,313,34.4,8.41,73.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function","PRKRA","ENSCATG00000032736; ENSG00000180228; ENSMNEG00000031681; ENSPANG00000001046; ENSPTRG00000012688","VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","",1870.7,2048.4,1977.5,1776.4,1676.3,1689.2,1.1467745385946833,0.1975817784293316,0.014136282868578844,1.849664773133877,0.07872760102558032,1.1038729821058815,1402]
["High","O75581","Low-density lipoprotein receptor-related protein 6 [OS=Homo sapiens]",11,13,17,13,1613,180.3,5.31,37.04,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","LRP6","ENSG00000070018; ENSG00000281324","MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Type I collagen synthesis in the context of osteogenesis imperfecta; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by WNT ligand antagonists; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","mTOR signaling pathway; Wnt signaling pathway; Parathyroid hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Pathways in cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer",647.6,661.8,665.5,713.9,704,699.9,0.932524317688167,-0.10078674748121784,2.2569700399627433E-3,2.646474205904612,0.03027907572513591,1.518857385895865,582]
["High","O75586","Mediator of RNA polymerase II transcription subunit 6 [OS=Homo sapiens]",9,2,3,2,246,28.4,8.62,2.57,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MED6","ENSG00000133997","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway","",123.7,111.6,93.7,102.4,113,114.9,0.9960641840750832,-0.005689385662921336,0.9659561776174712,0.015042575707297912,0.9833358324429224,7.298134997643476E-3,7670]
["High","O75592-1","E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",3,13,16,13,4640,509.8,7.03,32.47,"","","","","","","","",835.4,806.5,845.1,789.2,807.9,761.9,1.0542602797795675,0.07623108897744384,0.07335851018946979,1.1345494971725816,0.212299202208814,0.6730516378498317,2698]
["High","O75600-1","2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [OS=Homo sapiens]",3,1,1,1,419,45.3,8.05,2.88,"other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","GCAT","ENSG00000100116","","Threonine catabolism","Glycine, serine and threonine metabolism; Metabolic pathways",9.9,15.4,13.9,9.4,14.7,14.2,1.0234986945169715,0.03350926219025145,0.9048046453791456,0.04344517835520243,0.9501969967882137,0.022186346554540073,7435]
["High","O75607","Nucleoplasmin-3 [OS=Homo sapiens]",44,5,36,5,178,19.3,4.63,63.14,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NPM3","ENSG00000107833","","","",720.1,766.4,745,709.7,694.5,676.2,1.0726302634108826,0.10115286354301727,0.0380423495878926,1.419732667824417,0.14259945539235017,0.8458821331135276,2083]
["High","O75608","Acyl-protein thioesterase 1 [OS=Homo sapiens]",56,8,40,8,230,24.7,6.77,72.67,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LYPLA1","ENSG00000120992","","RAS processing; eNOS activation","Glycerophospholipid metabolism; Choline metabolism in cancer",1433.9,1457,1434.4,1503.3,1509.9,1596.5,0.9383040111070134,-0.09187266227868779,0.03765151452787148,1.4242175496659868,0.14195220928711758,0.847857843900804,2071]
["High","O75616-1","GTPase Era, mitochondrial [OS=Homo sapiens]",7,2,4,2,437,48.3,8.84,9.83,"cell organization and biogenesis","other membranes;cytosol;mitochondrion","translation activity;nucleic acid binding activity;other molecular function","ERAL1","ENSG00000132591","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",93.3,101.1,77.9,91.6,105.1,91.5,0.9448299791811241,-0.08187335313095168,0.5521971382016895,0.257905848450894,0.7263401710038395,0.13885993606322922,5936]
["High","O75643-1","U5 small nuclear ribonucleoprotein 200 kDa helicase [OS=Homo sapiens]",49,87,348,87,2136,244.4,6.06,756.77,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","SNRNP200","ENSCATG00000015790; ENSG00000144028; ENSGGOG00000005174; ENSMLEG00000019083; ENSPPAG00000041559; ENSPPYG00000012068; ENSPTRG00000012230; ENSRBIG00000044690; ENSRROG00000037952","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",14539.1,14880.6,13993.9,13589.5,14386.9,13993,1.0344107850005002,0.04880922220359698,0.2364249605848272,0.6263066746943121,0.43282675081977273,0.36368590553921853,4265]
["High","O75648-1","Mitochondrial tRNA-specific 2-thiouridylase 1 [OS=Homo sapiens]",14,4,4,4,421,47.7,8.03,6.21,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TRMU","ENSG00000100416","","tRNA modification in the mitochondrion","",112.5,104.3,105.8,106.5,122.2,118.7,0.9286125503742085,-0.10685131555474991,0.19954385311941286,0.69996164596784,0.3907796351031792,0.40806807697159914,3987]
["High","O75663","TIP41-like protein [OS=Homo sapiens]",31,8,25,8,272,31.4,5.91,37.38,"stress response;signal transduction;other biological processes","cytosol","","TIPRL","ENSG00000143155","Ciliary landscape","","",1291,1273.5,1299.7,1283.5,1322.7,1282.1,0.9938019185762416,-0.008969767813429378,0.6289413387327498,0.20138985924903158,0.7834674493977841,0.10597904238694868,6268]
["High","O75665","Oral-facial-digital syndrome 1 protein [OS=Homo sapiens]",9,7,7,7,1012,116.6,6.1,18.72,"cell organization and biogenesis;transport;developmental processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","OFD1","ENSG00000046651","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state","",144,171,171.3,184.3,192.5,178.4,0.875900576368876,-0.19116097633956336,0.08179589642482765,1.087268483672892,0.22623533803933912,0.6454395571611761,2823]
["High","O75674","TOM1-like protein 1 [OS=Homo sapiens]",11,4,5,4,476,53,5.24,16.3,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TOM1L1","ENSG00000141198","","","",138.7,164.8,156.6,169,187.8,190.9,0.8400584261457001,-0.2514384239252925,0.047175297835901936,1.3262853492853328,0.1624811316730138,0.7891970647532149,2267]
["High","O75676","Ribosomal protein S6 kinase alpha-4 [OS=Homo sapiens]",3,2,3,2,772,85.6,8.28,4.53,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","RPS6KA4","ENSG00000162302","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Interferon type I signaling pathways","Recycling pathway of L1","MAPK signaling pathway; TNF signaling pathway",60.3,60.6,74.1,86.2,75,77.4,0.8172673931265717,-0.29111991905825496,0.06282732825054627,1.2018514083839498,0.19427951642782781,0.7115729861799945,2525]
["High","O75683","Surfeit locus protein 6 [OS=Homo sapiens]",25,6,19,6,361,41.4,10.64,38.08,"other biological processes","nucleus;other cell component","nucleic acid binding activity","SURF6","ENSG00000148296; ENSG00000281309","","","",509.1,471.6,462.1,592,497.7,480.8,0.9186883158229864,-0.12235261475175656,0.31920174233689375,0.49593474675353433,0.5204274805108512,0.28363977913750665,4789]
["High","O75688","Protein phosphatase 1B [OS=Homo sapiens]",29,13,39,1,479,52.6,5.05,86.64,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus","other molecular function","PPM1B","ENSG00000138032","MAPK signaling pathway","ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","MAPK signaling pathway",1204.3,1229.1,1228.3,1252.6,1239.8,1228.1,0.9841956726246472,-0.022982921740470813,0.1432449253659771,0.8439207545235119,0.3198331075943807,0.49507658217412126,3497]
["High","O75688-2","Isoform Beta-2 of Protein phosphatase 1B [OS=Homo sapiens]",35,13,38,1,387,42.7,5.2,82.57,"","","","PPM1B","","","","",64.8,56.5,53.8,68.1,59.7,59.2,0.9363636363636363,-0.09485918634144135,0.4175058281316678,0.37933745764683047,0.6149567074235167,0.21115545721462162,5301]
["High","O75691","Small subunit processome component 20 homolog [OS=Homo sapiens]",20,40,75,40,2785,318.2,7.39,149.83,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","","UTP20","ENSG00000120800","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2436.7,2588.5,2345.8,2736.6,2798.4,2789,0.8855117731859683,-0.17541660665201367,0.012345668345637212,1.9084853941107147,0.07275092712659272,1.138161467724906,1325]
["High","O75694","nuclear pore complex protein nup155 [OS=Homo sapiens]",24,26,67,26,1391,155.1,6.16,169.68,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUP155","ENSG00000113569","","ISG15 antiviral mechanism; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis",3231.7,3370.9,3201.1,3211,3698.9,3316.9,0.9586283099307703,-0.0609565490535323,0.42012017689148395,0.3766264603277329,0.616829323273544,0.2098349886646457,5318]
["High","O75695","Protein XRP2 [OS=Homo sapiens]",23,7,16,7,350,39.6,5.12,27.49,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","RP2","ENSG00000102218","Joubert syndrome; Ciliopathies","Trafficking of myristoylated proteins to the cilium","",899,916.4,962.6,716.4,646.2,688.2,1.3545933294324166,0.43785979647145945,9.6056826013994623E-4,3.0174717677634875,0.02077594729964737,1.6824391650105102,361]
["High","O75717","WD repeat and HMG-box DNA-binding protein 1 [OS=Homo sapiens]",35,31,103,31,1129,125.9,5.62,237.63,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","WDHD1","ENSG00000198554","Mesodermal commitment pathway","","",3733.2,3832.6,3875.2,4326.9,4461.1,4327.5,0.8723266364225535,-0.1970596519604178,8.0869049032123721E-4,3.0922176638824523,0.01925077850130555,1.7155517029354959,328]
["High","O75718","Cartilage-associated protein [OS=Homo sapiens]",38,14,64,14,401,46.5,5.73,125.6,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cell component","","CRTAP","ENSG00000170275","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",3304.6,3289.4,3266.2,3270.6,3263.6,3253.1,1.0074484280649414,0.010705988153457547,0.118711393816226,0.9255075958386542,0.28371550747385754,0.5471169256554561,3267]
["High","O75746","Calcium-binding mitochondrial carrier protein Aralar1 [OS=Homo sapiens]",10,6,15,2,678,74.7,8.38,27.89,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A12","ENSG00000115840","","Mitochondrial protein import; Gluconeogenesis; Aspartate and asparagine metabolism","",214.4,220.5,241.4,243.7,246.4,247.4,0.9170169491525423,-0.12497969560101065,0.06873593097900946,1.1628161807479318,0.20390963111098248,0.6905622610312143,2632]
["High","O75781","Paralemmin-1 [OS=Homo sapiens]",17,5,6,5,387,42.1,5,11.9,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","signal transduction activity or receptor binding","PALM","ENSG00000099864","","","",316.2,309.1,297.8,306.3,261.3,253.1,1.1247715364932374,0.16963199109524635,0.12105599980810113,0.9170136810757968,0.28790899984820395,0.5407447591465016,3283]
["High","O75787","Renin receptor [OS=Homo sapiens]",25,8,15,8,350,39,6.1,37.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ATP6AP2","ENSG00000182220","ACE inhibitor pathway; Oxidative phosphorylation","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","Renin-angiotensin system",747.5,762.9,753.9,775.4,729.3,729.5,1.013472383851043,0.01930677728634379,0.5639385092800664,0.24876824803126163,0.7347291641012446,0.13387272106911113,5993]
["High","O75792","Ribonuclease H2 subunit A [OS=Homo sapiens]",21,7,11,7,299,33.4,5.25,31.7,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RNASEH2A","ENSG00000104889","","","DNA replication",371.8,357.2,380.8,416.9,400.5,405.1,0.9078118609406953,-0.13953475707582674,0.011211850407223882,1.9503227053953947,0.06997772020751725,1.1550402104301793,1251]
["High","O75794","Cell division cycle protein 123 homolog [OS=Homo sapiens]",35,9,16,9,336,39.1,4.81,39.97,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","other cell component","","CDC123","ENSG00000151465","","","",624,636.1,641.5,797.3,793.1,767.1,0.8066171792152704,-0.31004396250738653,1.4637417529461612E-4,3.8345355388265414,0.01058231074722558,1.9754194896548558,108]
["High","O75808-1","Calpain-15 [OS=Homo sapiens]",9,5,5,5,1086,117.2,6.71,12.48,"protein metabolism","other cell component","other molecular function","CAPN15","ENSG00000103326","","Degradation of the extracellular matrix","",222.3,183.7,231.3,177.9,177,183.1,1.1845724907063195,0.2443664879681571,0.08782115106842617,1.0564008749133702,0.23653244137367077,0.6261092856097322,2899]
["High","O75815-1","Breast cancer anti-estrogen resistance protein 3 [OS=Homo sapiens]",6,4,4,4,825,92.5,7.96,3.91,"developmental processes;signal transduction;other biological processes","other membranes;other cell component","enzyme regulator activity;other molecular function","BCAR3","ENSG00000137936","","","",136,140.4,114.4,155.1,133.1,131.3,0.9315852205005958,-0.10224034335880063,0.4371592392934194,0.3593603384313801,0.6330377114990762,0.19857041730000807,5392]
["High","O75817","Ribonuclease P protein subunit p20 [OS=Homo sapiens]",11,1,4,1,140,15.6,8.94,11.68,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP7","ENSG00000172336","","tRNA processing in the nucleus","Ribosome biogenesis in eukaryotes",102.2,92.9,99.3,96.7,90.7,88.7,1.066280333212604,0.09258678346894356,0.17003321477593944,0.7694662340046287,0.35573937325041133,0.4488680644204556,3732]
["High","O75818-1","Ribonuclease P protein subunit p40 [OS=Homo sapiens]",8,2,8,2,363,41.8,6.67,17.47,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP40","ENSG00000124787","","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","Ribosome biogenesis in eukaryotes",175.6,191.4,188.2,175.2,189.1,192.9,0.9964106245513282,-0.005187690022991808,0.9309171824515077,0.031088953609580843,0.9642612577051436,0.015805282064531564,7538]
["High","O75820-1","Zinc finger protein 189 [OS=Homo sapiens]",9,5,9,1,626,72.9,8.5,7.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF189","ENSG00000136870; ENSGGOG00000003650; ENSPPAG00000034345; ENSPPYG00000019452; ENSPTRG00000021200","","Generic Transcription Pathway","Herpes simplex virus 1 infection",119.9,140,130.4,129.5,142,160.4,0.9036814077332715,-0.1461138537680705,0.2642434133038557,0.577995829380768,0.4631229115772178,0.3343037330950262,4455]
["High","O75821","Eukaryotic translation initiation factor 3 subunit G [OS=Homo sapiens]",56,22,117,22,320,35.6,6.13,228.78,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3G","ENSG00000130811","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",4164.6,4007,4315.7,4463.7,4291.8,4530.1,0.9399123863431083,-0.08940181222398988,0.07978781454666165,1.0980634304441979,0.22329148959868605,0.65112782905916,2790]
["High","O75822","Eukaryotic translation initiation factor 3 subunit J [OS=Homo sapiens]",40,8,12,8,258,29,4.83,19.73,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3J","ENSG00000104131","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",964.1,741.3,535.5,1608.4,510.5,463.9,0.8676242837230912,-0.20485766207473846,0.786717340459036,0.10418127720766267,0.8833317506908474,0.053876158896266915,6954]
["High","O75828","Carbonyl reductase [NADPH] 3 [OS=Homo sapiens]",35,6,16,4,277,30.8,6.18,47,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CBR3","ENSG00000159231","Nuclear receptors meta-pathway; NRF2 pathway","Phase I - Functionalization of compounds","Arachidonic acid metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways",223.2,219.8,246,270.1,242.5,272.4,0.8777070063694267,-0.18818867107469817,0.06464365212930427,1.1894741154946276,0.19685555219407477,0.705852331682772,2564]
["High","O75832","26S proteasome non-ATPase regulatory subunit 10 [OS=Homo sapiens]",52,10,64,10,226,24.4,6.1,103.3,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PSMD10","ENSG00000101843","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway","Degradation of DVL; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","",2241.6,2258.9,2246.2,2173.9,2139.3,2187.8,1.0377941855099213,0.0535203579680031,0.005900938015926962,2.229078947211919,0.048346824793659725,1.31563204319161,953]
["High","O75844","caax prenyl protease 1 homolog [OS=Homo sapiens]",16,7,48,7,475,54.8,7.49,80.53,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZMPSTE24","ENSG00000084073","Adipogenesis; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy","","Terpenoid backbone biosynthesis",1804.3,1964.9,1824.5,1751,1859.6,1847.1,1.0249189218901735,0.035509787181011485,0.4990176056748701,0.3018841319065383,0.6852496421226496,0.1641511826023262,5686]
["High","O75864-1","Protein phosphatase 1 regulatory subunit 37 [OS=Homo sapiens]",9,4,5,4,691,74.7,5.06,9.53,"other biological processes","","enzyme regulator activity","PPP1R37","ENSG00000104866; ENSPPAG00000031033","","","",136.4,133.7,125.1,112.9,116.8,118.8,1.1340028694404591,0.18142429082889225,0.015188666480655286,1.8184803542159205,0.08201459742804736,1.0861088425157972,1446]
["Medium","O75865-1","Trafficking protein particle complex subunit 6A [OS=Homo sapiens]",6,1,1,1,159,17.6,5.26,0,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC6A","ENSG00000007255","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",18.3,22.5,12,16.5,13.5,18.3,1.093167701863354,0.1285147405226804,0.67813241193647,0.16868549763927684,0.8163518150477888,0.0881226373175954,6486]
["High","O75874","Isocitrate dehydrogenase [NADP] cytoplasmic [OS=Homo sapiens]",73,28,435,27,414,46.6,7.01,794.24,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","IDH1","ENSG00000138413","Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism","Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration","Citrate cycle (TCA cycle); Glutathione metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Peroxisome; Central carbon metabolism in cancer",14434.5,14297.4,14759.5,14493.7,14094.8,14528.3,1.0086880287962,0.012480040744921497,0.557270362847072,0.2539340532908911,0.730306645369241,0.13649474751128055,5958]
["High","O75879","Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial [OS=Homo sapiens]",13,5,11,5,557,61.8,8.63,16.71,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","other molecular function","GATB","ENSG00000059691","","","Aminoacyl-tRNA biosynthesis; Metabolic pathways",240.2,277.7,273.1,291.6,277.5,275.7,0.9363162878787881,-0.094932139998299,0.23483234572827574,0.6292420837284904,0.430820243290972,0.3657038983568468,4256]
["High","O75880","Protein SCO1 homolog, mitochondrial [OS=Homo sapiens]",8,3,5,3,301,33.8,8.88,9.23,"cell organization and biogenesis;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO1","ENSG00000133028","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","",343.9,375.2,353.3,364.3,351.6,337.1,1.018423551756885,0.026337688069481727,0.6228686505581765,0.20560352693965367,0.7781373477693188,0.10894373962509349,6250]
["High","O75882-1","Attractin [OS=Homo sapiens]",5,6,10,6,1429,158.4,7.31,11.5,"cell adhesion;stress response;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","ATRN","ENSG00000088812","","","",257.5,233.6,271.2,213.1,218.4,216.7,{"$f":"AVERAGE(T706:V706)/AVERAGE(W706:Y706)","v":1.1760259179265657},{"$f":"LOG(Z706,2)","v":0.23391985545667032},{"$f":"TTEST(T706:V706,W706:Y706,2,2)","v":0.02660046676193465},{"$f":"-LOG10(AB706)","v":1.5751107426789306},{"$f":"AB706*7808/AF706","v":0.11474941683822418},{"$f":"-LOG10(AD706)","v":0.9402495128894798},1810]
["High","O75884-1","Putative hydrolase RBBP9 [OS=Homo sapiens]",6,2,3,2,186,21,6.2,7.2,"other biological processes","nucleus","other molecular function","RBBP9","ENSG00000089050; ENSPPAG00000038694; ENSPTRG00000013289","","","",294.2,306.6,266.7,266.4,312.1,272.7,1.0191494360902256,0.02736560685179601,0.7839733167526953,0.10569871867305149,0.8811377079609969,0.054956212888771366,6947]
["High","O75886","Signal transducing adapter molecule 2 [OS=Homo sapiens]",17,8,16,7,525,58.1,5.07,18.11,"cell organization and biogenesis;other metabolic processes;transport;signal transduction","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STAM2","ENSG00000115145","EGF/EGFR signaling pathway","Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell","Endocytosis; JAK-STAT signaling pathway",491.7,526.8,507.2,439.2,430.8,462.1,1.1453344343517755,0.19576892262927414,0.009488765274600913,2.0227902964572935,0.06359508949706774,1.196576417160696,1165]
["High","O75907","Diacylglycerol O-acyltransferase 1 [OS=Homo sapiens]",10,4,6,4,488,55.2,9.32,20.93,"cell organization and biogenesis;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","DGAT1","ENSG00000185000; ENSG00000285482","Triacylglyceride synthesis; Statin inhibition of cholesterol production; Glycerolipids and glycerophospholipids; Congenital generalized lipodystrophy (CGL); Vitamin A and carotenoid metabolism","Neutrophil degranulation; Acyl chain remodeling of DAG and TAG; Triglyceride biosynthesis","Glycerolipid metabolism; Retinol metabolism; Metabolic pathways; Fat digestion and absorption",370.9,394.7,363.8,255,272.1,265.3,1.425290257445734,0.5112557510918025,4.4611795094578842E-4,3.350550301215118,0.01597838972928769,1.7964669901610875,218]
["High","O75909","Cyclin-K [OS=Homo sapiens]",18,7,20,7,580,64.2,8.41,44.16,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNK","ENSG00000090061","Male infertility","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes","",830.4,829.4,843.3,799.5,799.4,804.6,1.0414395672976908,0.058579125034349054,2.2819346922973963E-3,2.6416967890066414,0.030250163119623207,1.5192722791351074,589]
["High","O75915","PRA1 family protein 3 [OS=Homo sapiens]",20,3,9,3,188,21.6,9.77,6.29,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","ARL6IP5","ENSG00000144746","","Glutamate Neurotransmitter Release Cycle","",87.9,112.6,97.1,106.9,110.7,116.4,0.8910179640718564,-0.166473576253383,0.19102344447747657,0.7189133281325736,0.3817535332685275,0.4182169346987227,3907]
["High","O75923-1","dysferlin [OS=Homo sapiens]",16,24,35,24,2080,237.1,5.64,65.88,"cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYSF","ENSG00000135636","","Smooth Muscle Contraction","",869,874.9,838.9,884.2,916.2,875,0.9653883531434552,-0.050818673287711245,0.13893542496222644,0.8571870062128725,0.31334713983392953,0.5039742650936121,3462]
["High","O75925","E3 SUMO-protein ligase PIAS1 [OS=Homo sapiens]",11,5,9,4,651,71.8,7.3,16,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS1","ENSG00000033800","Androgen receptor signaling pathway; Interleukin-11 signaling pathway; Mesodermal commitment pathway; TGF-beta signaling pathway; Immune response to tuberculosis; Interferon type I signaling pathways","SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway; Hepatitis C",179,209.6,202.2,195.2,210,189.5,0.9934420716327558,-0.00949224961141493,0.9120837110077388,0.03996530031155781,0.953353362188544,0.020746097468321203,7470]
["High","O75928-1","E3 SUMO-protein ligase PIAS2 [OS=Homo sapiens]",10,4,7,3,621,68.2,7.52,10.59,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS2","ENSG00000078043; ENSPTRG00000009998","Androgen receptor signaling pathway; TGF-beta signaling pathway","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway",32.9,34.8,30.2,38.1,29.7,24.5,1.0606717226435536,0.08497821195792073,0.6783505802555688,0.16854579917129298,0.8162369133357191,0.08818376867141146,6489]
["High","O75934","Pre-mRNA-splicing factor spf27 [OS=Homo sapiens]",48,10,26,10,225,26.1,5.66,64.74,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","","BCAS2","ENSG00000116752","","mRNA Splicing - Major Pathway","Spliceosome",1282.9,1299.7,1226.4,1218.6,1133.7,1107.7,1.1008670520231216,0.13864025003925337,0.04426069018363209,1.3539818181402143,0.15581040079071204,0.8074035552947203,2218]
["High","O75935","Dynactin subunit 3 [OS=Homo sapiens]",24,4,11,4,186,21.1,5.47,18.4,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DCTN3","ENSG00000137100","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection",309.8,291.3,271.7,276.3,273.5,294.5,1.033755774013976,0.04789538755187312,0.49980258801098654,0.301201499398083,0.6851226487341613,0.1642316753682476,5696]
["High","O75937","DnaJ homolog subfamily C member 8 [OS=Homo sapiens]",16,4,8,4,253,29.8,9.06,12.9,"","non-structural extracellular;cytosol;nucleus","other molecular function","DNAJC8","ENSG00000126698; ENSG00000285317","mRNA processing","mRNA Splicing - Major Pathway","",715.3,614.7,458.7,1255.9,544.5,430.9,0.8016402993770447,-0.3189730585972376,0.6122151616340584,0.2130959192135733,0.7703748560900447,0.11329790038968657,6205]
["High","O75940","Survival of motor neuron-related-splicing factor 30 [OS=Homo sapiens]",37,7,16,7,238,26.7,7.24,32.33,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","SMNDC1","ENSG00000119953","","mRNA Splicing - Major Pathway","Spliceosome",785.9,697.9,770.7,941.3,822.8,778.3,0.8867605412208938,-0.17338351982363578,0.1600645368151903,0.7957048777714408,0.3433472262233533,0.46426645676186146,3640]
["High","O75943-1","cell cycle checkpoint protein RAD17 [OS=Homo sapiens]",9,6,8,6,681,77,7.06,13.11,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","RAD17","ENSG00000152942; ENSG00000276618","miRNA regulation of DNA damage response; Gastric cancer network 2; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","",240.9,215.9,226.7,233.2,233.8,221.1,0.9933149251562273,-0.009676905904762322,0.863037155662583,0.06397050654218295,0.9269042794241331,0.0329651127425854,7270]
["High","O75947-1","ATP synthase subunit d, mitochondrial [OS=Homo sapiens]",41,6,20,6,161,18.5,5.3,16.06,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5PD","ENSG00000167863; ENSGGOG00000013716; ENSPTRG00000009628","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",529.8,672.9,522.2,744.8,500.7,463.6,1.009244631677491,0.013275912929040188,0.9608772993728112,0.017332066657705293,0.9813642843038469,8.16975174740882E-3,7645]
["High","O75953","dnaJ homolog subfamily B member 5 [OS=Homo sapiens]",30,8,18,8,348,39.1,9.04,37.35,"stress response;other biological processes","cytosol","other molecular function","DNAJB5","ENSG00000137094","","","",416.6,446.3,401.3,373.6,392.9,329.2,1.1537829697910011,0.20637187402435042,0.07125632251019128,1.1471765950462358,0.20876899293042156,0.6803340037501916,2665]
["High","O75954","tetraspanin-9 [OS=Homo sapiens]",14,2,3,2,239,26.8,7.68,9.46,"","plasma membrane;other membranes","","TSPAN9","ENSG00000011105","","","",19.4,19,23.9,23.7,22.9,28.2,0.8328877005347594,-0.2638061068636348,0.1413654192092911,0.8496568146078304,0.3167234413733558,0.49931979238322327,3485]
["High","O75955","Flotillin-1 [OS=Homo sapiens]",34,13,37,12,427,47.3,7.49,78.73,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","FLOT1","ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules","Insulin signaling pathway",1020.3,1083.7,934.2,996.9,1135,988.9,0.973532427582671,-0.03869906012921415,0.6902507883380486,0.16099308867903764,0.8235755127358625,0.08429657468366882,6544]
["High","O75962-1","Triple functional domain protein [OS=Homo sapiens]",5,12,14,12,3097,346.7,6.37,23.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;kinase activity;other molecular function","TRIO","ENSG00000038382","Microtubule cytoskeleton regulation; Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; G alpha (q) signalling events; DCC mediated attractive signaling","",352,358.2,368.7,325.7,336.4,315,1.1041858561048001,0.1429830263854416,0.012522302201000247,1.9023158195859478,0.0732939547117016,1.1349318445078427,1334]
["High","O75964","ATP synthase subunit g, mitochondrial [OS=Homo sapiens]",39,4,21,4,103,11.4,9.64,39.98,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5MG","ENSG00000167283","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis",630,683.3,575.3,598.7,698.4,654.3,0.9678179768371427,-0.04719235793248934,0.6479501240231853,0.18845842267132248,0.7944715088525488,0.0999216727422997,6368]
["Low","O75969","A-kinase anchor protein 3 [OS=Homo sapiens]",1,1,1,1,853,94.7,6.18,0,"developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","AKAP3","ENSG00000111254","G protein signaling pathways","","",35.5,29.3,30.6,29.9,32.5,36.6,0.9636363636363636,-0.05343925896146044,0.6812511478956538,0.1666927529364707,0.8170827899799178,0.08773393684602725,6510]
["High","O75970","multiple PDZ domain protein [OS=Homo sapiens]",11,16,24,16,2070,221.5,5.06,47.36,"","plasma membrane;other membranes;other cell component","other molecular function","MPDZ","ENSG00000107186","","","Tight junction",1215,1191.4,1184.2,1440,1353.4,1394.2,0.8574362403285892,-0.2218986996156,1.7280922949956833E-3,2.7624330661760377,0.027148781970475447,1.5662496502507346,497]
["High","O75976","Carboxypeptidase D [OS=Homo sapiens]",15,16,26,16,1380,152.8,6.05,45.84,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","CPD","ENSG00000108582","","Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle; RND1 GTPase cycle","",696.5,680.8,749.8,747.8,742,716.9,0.9639280373408257,-0.05300264972549052,0.31166851129527645,0.5063070734418323,0.5125332216077335,0.29027797906575054,4748]
["High","O76003","glutaredoxin-3 [OS=Homo sapiens]",36,11,67,11,335,37.4,5.39,164.17,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","GLRX3","ENSG00000108010","","Iron uptake and transport","",3266.9,3371.2,3349.6,3385.1,3507.9,3459.3,0.9647807733547136,-0.05172693812842368,0.0638184260424272,1.1950539110406266,0.1957934265380242,0.7082018930547687,2545]
["High","O76021","Ribosomal L1 domain-containing protein 1 [OS=Homo sapiens]",48,24,127,24,490,54.9,10.13,233.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RSL1D1","ENSG00000171490","","","",5537,5522.6,5768.8,6517.9,6465,6718.9,0.8541554578769454,-0.22742942797208388,9.9557103327836878E-4,3.0019277479316386,0.021066175143191066,1.6764143094320634,369]
["High","O76024","Wolframin [OS=Homo sapiens]",18,14,33,14,890,100.2,8.05,64.28,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","WFS1","ENSG00000109501","CAMKK2 pathway","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes","Protein processing in endoplasmic reticulum",1314.7,1315.6,1379,1179.5,1300.2,1231.3,1.0803826461870116,0.11154237163388624,0.07202840752827284,1.1424961869077324,0.2098499276047591,0.6780911762778857,2680]
["High","O76031","ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial [OS=Homo sapiens]",39,20,48,20,633,69.2,7.58,90.67,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","CLPX","ENSG00000166855","","","",2314.4,2206.8,2340.7,2422.2,2394,2405.8,0.9501384657989477,-0.07379031895457017,0.04529421646986125,1.3439572486621993,0.15851960654266098,0.7999170142874017,2231]
["High","O76039-1","Cyclin-dependent kinase-like 5 [OS=Homo sapiens]",3,2,2,1,1030,115.5,9.54,2.72,"","","","CDKL5","","","","",14.3,12.2,14.2,22.2,23.9,26.5,0.5606060606060607,-0.8349407537295035,1.7244141800171822E-3,2.7633584145598014,0.027200456399139712,1.5654238088347348,495]
["High","O76041-2","Isoform 2 of Nebulette [OS=Homo sapiens]",10,3,3,2,270,31.2,8.31,7.4,"","","","NEBL","","","","",86,83.7,84,115.6,105.2,109.5,0.7680896155010596,-0.38065345022158603,1.1882156315752412E-3,2.925104738559049,0.023193969128348705,1.634624925228376,400]
["High","O76062","Delta(14)-sterol reductase [OS=Homo sapiens]",5,2,3,2,418,46.4,8.87,8.9,"other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","TM7SF2","ENSG00000149809","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Steroid biosynthesis; Metabolic pathways",221,247.5,209.5,207.7,215.2,209.1,1.0727848101265822,0.1013607149592409,0.25273648287116746,0.5973320625280367,0.4508490880187515,0.34596880448251544,4377]
["High","O76064","E3 ubiquitin-protein ligase RNF8 [OS=Homo sapiens]",11,4,5,4,485,55.5,7.33,9.64,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","RNF8","ENSG00000112130","ATM signaling in development and disease ; 3q29 copy number variation syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome","Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Nonhomologous End-Joining (NHEJ)","",126,131.7,145.9,146.8,132,120.6,1.0105157736604908,0.015091841662384808,0.8913242323714627,0.04996428618154172,0.9427607161143838,0.025598522382544665,7382]
["High","O76070","Gamma-synuclein [OS=Homo sapiens]",76,8,15,7,127,13.3,4.86,35.71,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","cytoskeleton;other cell component","other molecular function","SNCG","ENSG00000173267","","","",528.3,557.7,576.9,614.5,568.4,604.7,0.9302416648019692,-0.1043225363868792,0.10507514056468925,0.9785000203429578,0.26304158304876357,0.5799755904414662,3119]
["High","O76071","Probable cytosolic iron-sulfur protein assembly protein Ciao1 [OS=Homo sapiens]",33,8,19,8,339,37.8,4.97,62.4,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","","CIAO1","ENSG00000144021","","Cytosolic iron-sulfur cluster assembly","",645.3,647.6,693.7,635,610.1,632.8,1.0578838063794667,0.08118117644457291,0.10946385925019128,0.9607292444676171,0.2698749014921041,0.5688375031808937,3167]
["High","O76074","cGMP-specific 3',5'-cyclic phosphodiesterase [OS=Homo sapiens]",8,6,8,6,875,99.9,6.09,8.24,"other metabolic processes;signal transduction","cytosol","other molecular function","PDE5A","ENSG00000138735","Phosphodiesterases in neuronal function","cGMP effects; RHOBTB1 GTPase cycle","Purine metabolism; Metabolic pathways; cGMP-PKG signaling pathway",63.1,75,80,80.7,78.9,77.3,0.9206416209371041,-0.11928842859948097,0.28712745369953774,0.54192528043909,0.4878979670263309,0.3116709915025847,4595]
["High","O76075","DNA fragmentation factor subunit beta [OS=Homo sapiens]",12,3,4,3,338,39.1,9,5.11,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DFFB","ENSG00000169598","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis","Apoptosis induced DNA fragmentation","Apoptosis",143.8,135.9,127.8,159.7,151.1,155.6,0.8737135506003431,-0.19476772919469418,0.02005511426831246,1.697774859189381,0.0957739034905099,1.0187528115270506,1635]
["High","O76080","AN1-type zinc finger protein 5 [OS=Homo sapiens]",29,4,5,4,213,23.1,8.51,17.66,"developmental processes;signal transduction;other biological processes","other cell component","nucleic acid binding activity;other molecular function","ZFAND5","ENSG00000107372","","","",295.1,344.1,317.4,305.8,327.4,310.9,1.0132401228683403,0.018976111966725665,0.8025039298287869,0.0955528321956409,0.8922042836541604,0.04953569595329228,7023]
["High","O76094","Signal recognition particle subunit SRP72 [OS=Homo sapiens]",36,20,56,20,671,74.6,9.26,128.38,"transport","cytosol;ER/Golgi;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","SRP72","ENSG00000174780","","SRP-dependent cotranslational protein targeting to membrane","Protein export",2249.8,2448.6,2131.8,2171,2504.1,2328.6,0.9752273798135269,-0.036189464246410216,0.6870205071272748,0.16303029933158114,0.8216045519451313,0.085337163277409,6529]
["Medium","O76095-1","Protein JTB [OS=Homo sapiens]",9,1,2,1,146,16.3,8.28,2.18,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","other molecular function","JTB","ENSG00000143543; ENSGGOG00000005608; ENSPPAG00000028370; ENSPTRG00000001369","","","",37.9,49.3,39.8,45.2,36.3,43.3,1.017628205128205,0.02521056279727977,0.8769613603801562,0.0570195415750851,0.9341492908387803,0.02958371155757762,7330]
["High","O77932","Decapping and exoribonuclease protein [OS=Homo sapiens]",4,2,3,2,396,44.9,7.69,4.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","DXO","ENSG00000204348; ENSG00000206346; ENSG00000224313; ENSG00000225682; ENSG00000234798; ENSG00000236765","","","",68.9,86.2,76.9,87.4,81.7,103.5,0.851063829787234,-0.232660756790275,0.17509672174560711,0.7567219849338064,0.3623522935037637,0.44086898547616654,3773]
["High","O94760-1","N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [OS=Homo sapiens]",29,7,24,6,285,31.1,5.81,61.15,"other metabolic processes;signal transduction;other biological processes","cytosol","other molecular function","DDAH1","ENSG00000153904; ENSMFAG00000037521; ENSMMUG00000014573; ENSMNEG00000044101; ENSRBIG00000034663; ENSRROG00000009892","Mesodermal commitment pathway; Nitric oxide metabolism in cystic fibrosis","eNOS activation","",918.4,894.5,906.9,930.2,896.2,923,0.9892340146941151,-0.015616247408980018,0.4719195921564629,0.32613199216581623,0.6624861876227368,0.17882317203532158,5562]
["High","O94761","ATP-dependent DNA helicase Q4 [OS=Homo sapiens]",6,5,7,5,1208,133,8.09,14.84,"","","","","","","","",150.6,122.5,135.8,124.1,122,111.5,1.1434563758389262,0.19340132634304802,0.13033281273885036,0.8849462320432033,0.3005430011414482,0.5220933811574844,3386]
["High","O94762-1","ATP-dependent DNA helicase Q5 [OS=Homo sapiens]",9,8,9,8,991,108.8,8.56,13.93,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RECQL5","ENSG00000108469","","","",346,366.8,359.7,391.4,388.5,404.5,0.9055217831813577,-0.1431787479032835,0.00892591016369548,2.049347488502398,0.06118832884823029,1.213331407922863,1139]
["High","O94763-1","Unconventional prefoldin RPB5 interactor 1 [OS=Homo sapiens]",19,9,15,9,535,59.8,5.05,26.66,"other biological processes","cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","URI1","ENSG00000105176","","","",565.9,540,581.1,553.2,584.9,564.1,0.991070379508871,-0.012940582820586842,0.755304783188559,0.12187776499723278,0.865231770413185,0.06286754209724106,6816]
["High","O94766","Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 [OS=Homo sapiens]",26,8,12,8,335,37.1,8.27,26.73,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","B3GAT3","ENSG00000149541","Proteoglycan biosynthesis","A tetrasaccharide linker sequence is required for GAG synthesis; Defective B3GAT3 causes JDSSDHD","Glycosaminoglycan biosynthesis; Glycosaminoglycan biosynthesis; Metabolic pathways",506.3,505.6,522.1,443.8,464.7,448.4,1.1305180927113272,0.1769840810377283,2.0837767626995696E-3,2.681148809326815,0.029368463832415596,1.5321187693966096,554]
["High","O94768","Serine/threonine-protein kinase 17B [OS=Homo sapiens]",5,2,2,2,372,42.3,5.25,2.06,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus","kinase activity;other molecular function","STK17B","ENSG00000081320","","","",50.5,51.9,49.7,53.3,52,46.3,1.003298153034301,0.004750399553405331,0.9443538072559654,0.024865264440065045,0.9723743277139099,0.012166515767992157,7583]
["High","O94776","Metastasis-associated protein MTA2 [OS=Homo sapiens]",34,22,66,20,668,75,9.66,131.78,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MTA2","ENSG00000149480","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","",2224.7,2207.2,2297.2,2215.4,2237.8,2241.8,1.005093353248693,0.007329505398415824,0.7127459705221479,0.14706522927622645,0.8392581115724523,0.07610445252959987,6631]
["High","O94782","Ubiquitin carboxyl-terminal hydrolase 1 [OS=Homo sapiens]",11,7,7,7,785,88.2,5.45,13.61,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus","other molecular function","USP1","ENSG00000162607","miR-517 relationship with ARCN1 and USP1; DNA repair pathways, full network","Fanconi Anemia Pathway; Recognition of DNA damage by PCNA-containing replication complex","Fanconi anemia pathway",341,300,345.5,383.8,364.4,376.6,0.8770448079658604,-0.1892775434616146,0.04130937586690995,1.3839513666212024,0.14981124327395862,0.8244555917860541,2153]
["High","O94788-1","retinal dehydrogenase 2 [OS=Homo sapiens]",5,5,11,2,518,56.7,6.05,23.03,"cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","ALDH1A2","ENSG00000128918","Ethanol effects on histone modifications; Tryptophan metabolism; 22q11.2 copy number variation syndrome; Vitamin A and carotenoid metabolism","RA biosynthesis pathway","Retinol metabolism; Metabolic pathways",367.4,389.4,406.3,438.5,410,423.4,0.9144586838587938,-0.12901010581938344,0.060058425490929206,1.221426057577671,0.1886308070125403,0.7243873772246615,2486]
["High","O94804","Serine/threonine-protein kinase 10 [OS=Homo sapiens]",13,10,11,9,968,112.1,6.95,16.66,"cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","kinase activity;other molecular function","STK10","ENSG00000072786","","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation","Progesterone-mediated oocyte maturation",196.1,169.2,163.9,202.2,193.9,198.4,0.8901597981497056,-0.1678637483543415,0.10099819495359132,0.9956863878876543,0.2576262352818167,0.5890099128263535,3061]
["High","O94808","Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [OS=Homo sapiens]",42,25,94,18,682,76.9,7.37,224.33,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","GFPT2","ENSG00000131459","","Synthesis of UDP-N-acetyl-glucosamine","Alanine, aspartate and glutamate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars; Insulin resistance; Diabetic cardiomyopathy",2933.3,3077.5,2662.6,1625.7,1771.2,1741.6,1.6879244915831468,0.7552503672826029,0.000808250713283161,3.0924539034503327,0.01929914853001505,1.7144618514519832,327]
["High","O94819","Kelch repeat and BTB domain-containing protein 11 [OS=Homo sapiens]",6,2,3,2,623,65.7,6.07,7.41,"","","","KBTBD11","ENSG00000176595; ENSG00000273645","","","",33.3,39,39.2,39.9,43.3,37.7,0.9222497932175352,-0.11677053444145641,0.28304754690887085,0.5481406046675965,0.4833847870219737,0.3157070217322052,4572]
["High","O94822","E3 ubiquitin-protein ligase listerin [OS=Homo sapiens]",18,25,40,25,1766,200.4,6.25,71.97,"protein metabolism;other metabolic processes","cytosol;other cell component","translation activity;other molecular function","LTN1","ENSG00000198862","","Antigen processing: Ubiquitination & Proteasome degradation","",1757.8,1865.7,1914.5,1981.7,1911.7,1931.2,0.9507949043711155,-0.07279392347304468,0.1330605664795756,0.8759506319614403,0.30431660898433693,0.5166743440815197,3414]
["High","O94826","Mitochondrial import receptor subunit TOM70 [OS=Homo sapiens]",48,25,95,25,608,67.4,7.12,193.99,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TOMM70","ENSG00000154174","Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation","Mitochondrial protein import; Ub-specific processing proteases; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PINK1-PRKN Mediated Mitophagy","",3576.9,3510.2,3541.8,3497.8,3403.8,3516,1.0202829826447553,0.02896934929132758,0.15107237951194646,0.8208149302476136,0.33180679021920617,0.47911473065476334,3555]
["High","O94829","Importin-13 [OS=Homo sapiens]",10,7,10,7,963,108.1,5.3,17.08,"transport","nucleus;other cell component","other molecular function","IPO13","ENSG00000117408","","","Nucleocytoplasmic transport",278.7,333.8,314.8,302.5,317.1,307,1.0007554500323763,1.0894725461079687E-3,0.9895376473076208,0.004567678257046062,0.9954019518394619,0.002001512002406783,7762]
["High","O94830","Phospholipase DDHD2 [OS=Homo sapiens]",14,6,6,6,711,81,5.39,5.24,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","DDHD2","ENSG00000085788","","Synthesis of PA","",118.4,119.5,129.7,115.7,130.3,135.5,0.9635648754914811,-0.05354629043285821,0.5405244664444186,0.2671846432438471,0.7166607291557175,0.14468639290488036,5889]
["High","O94832","Unconventional myosin-Id [OS=Homo sapiens]",8,7,8,7,1006,116.1,9.39,14.9,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1D","ENSG00000176658","","","Pathogenic Escherichia coli infection",360.8,413.8,360.4,264.6,300.5,308.5,1.2992216117216118,0.3776475361457873,0.017399508309116483,1.7594630242262892,0.08873635589652612,1.051898410265915,1531]
["High","O94842","TOX high mobility group box family member 4 [OS=Homo sapiens]",9,4,7,4,621,66.2,5.06,12.49,"other biological processes","nucleus;other cell component","nucleic acid binding activity","TOX4","ENSG00000092203","","","",258.4,267.8,257.3,217.6,243,233.7,1.1284747227423306,0.17437410325929345,0.021660367065644937,1.664334187912299,0.10043001546826347,0.9981364704172943,1684]
["High","O94854","Uncharacterized protein KIAA0754 [OS=Homo sapiens]",9,7,11,7,1291,135.1,4.21,28.81,"","","","KIAA0754","","","","",179.1,180.5,197.4,197.7,163.4,179.6,1.0301461068984648,0.042848971145394515,0.6617708410922445,0.17929237261243475,0.8048452846181067,0.09428759602265262,6420]
["High","O94855","Protein transport protein Sec24D [OS=Homo sapiens]",18,15,33,15,1032,112.9,7.25,62.42,"cell organization and biogenesis;transport;developmental processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC24D","ENSG00000150961","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",1328,1347.9,1321.4,1348.2,1492.3,1417.2,0.9388402188975269,-0.09104844821038634,0.10983763801611234,0.9592488148790781,0.2705401506718628,0.5677682724381942,3170]
["Low","O94856","Neurofascin [OS=Homo sapiens]",1,1,2,1,1347,149.9,6.65,0,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","NFASC","ENSG00000163531","","Neutrophil degranulation; Neurofascin interactions; Interaction between L1 and Ankyrins","Cell adhesion molecules",101.3,105.7,99.7,105,100,106.8,0.9836433611289288,-0.02379276143076517,0.564776745128283,0.24812319380891834,0.7353304695617199,0.1335174379880623,5997]
["High","O94864-1","STAGA complex 65 subunit gamma [OS=Homo sapiens]",17,3,9,3,414,46.2,5.12,0,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SUPT7L","ENSG00000119760; ENSPTRG00000011777","","HATs acetylate histones","",64,59.2,49.4,55.7,54.3,53.9,1.0530811470408785,0.07461661007949608,0.5397654532278612,0.26779491517156057,0.7158975129612944,0.14514914632509412,5887]
["High","O94874-1","E3 UFM1-protein ligase 1 [OS=Homo sapiens]",16,11,28,11,794,89.5,6.79,48.52,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UFL1","ENSG00000014123","","Antigen processing: Ubiquitination & Proteasome degradation","",1342.7,1476.4,1442.7,1312.5,1415,1346.3,1.046148559084884,0.06508773708829596,0.2800724110422652,0.5527296699062627,0.4813571176354846,0.3175326020622535,4543]
["High","O94875-1","Sorbin and SH3 domain-containing protein 2 [OS=Homo sapiens]",1,1,1,1,1100,124,8.31,2.53,"cell organization and biogenesis;developmental processes;signal transduction","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SORBS2","ENSG00000154556","Extracellular vesicles in the crosstalk of cardiac cells","","",39.4,34.6,37.8,37.4,33,41.8,0.9964349376114082,-0.005152487765602714,0.9656027247235554,0.01520151742320177,0.9833606462294927,0.007287176020800808,7667]
["High","O94876","Transmembrane and coiled-coil domains protein 1 [OS=Homo sapiens]",15,7,9,6,653,72,6.55,15.21,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TMCC1","ENSG00000172765","","","",239.8,238.2,256.7,256.8,218,233.3,1.037565315633385,0.05320215821798932,0.5248119665133831,0.2799962709428386,0.704319669050618,0.15223018319524353,5818]
["High","O94880","PHD finger protein 14 [OS=Homo sapiens]",14,9,18,9,888,100,5.33,23.63,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF14","ENSG00000106443","","","",486,476.1,499.3,555.1,538.2,542.8,{"$f":"AVERAGE(T770:V770)/AVERAGE(W770:Y770)","v":0.8932216857160321},{"$f":"LOG(Z770,2)","v":-0.16290981742245964},{"$f":"TTEST(T770:V770,W770:Y770,2,2)","v":2.2768492730190185E-3},{"$f":"-LOG10(AB770)","v":2.6426657186438747},{"$f":"AB770*7808/AF770","v":0.0302340801424022},{"$f":"-LOG10(AD770)","v":1.5195032400613777},588]
["High","O94885","SAM and SH3 domain-containing protein 1 [OS=Homo sapiens]",7,6,7,6,1247,136.6,6.09,16.32,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","SASH1","ENSG00000111961","","","",245,213.1,241.6,327.3,265,292.2,0.7910684002261166,-0.33812565126306493,0.040764104550457696,1.3897220932164698,0.1485236249789891,0.828204459599663,2143]
["High","O94887-1","FERM, RhoGEF and pleckstrin domain-containing protein 2 [OS=Homo sapiens]",6,4,6,4,1054,119.8,8.79,7.26,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity","FARP2","ENSG00000006607","","RAC1 GTPase cycle; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Rap1 signaling pathway; Adherens junction",165.9,174.8,158.9,142.8,148.5,133.5,1.1760828625235404,0.23398971080380368,0.017121902119575903,1.766447990000672,0.08789468228116283,1.056037399395035,1521]
["High","O94888","UBX domain-containing protein 7 [OS=Homo sapiens]",41,15,50,15,489,54.8,5.16,88.4,"","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","UBXN7","ENSG00000163960","3q29 copy number variation syndrome","Neddylation","",1777.5,1807.8,1813.1,2011.9,1839.6,1967.7,0.9276876546604343,-0.10828895216805126,0.056722316479416314,1.2462460413354803,0.1818841261073029,0.7402052022274981,2435]
["High","O94889","Kelch-like protein 18 [OS=Homo sapiens]",8,4,7,3,574,63.6,5.6,13.5,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","","","KLHL18","ENSG00000114648","","","",67.7,49.4,59.7,53.9,53,57.9,1.0728155339805825,0.10140203220821314,0.5078178664154749,0.2942920235309178,0.6917379450404795,0.16005840059758925,5732]
["High","O94898","Leucine-rich repeats and immunoglobulin-like domains protein 2 [OS=Homo sapiens]",2,1,1,1,1065,118.9,5.55,3.51,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","LRIG2","ENSG00000198799","","","Axon guidance",47.7,66.1,61.6,47.7,51.9,60.7,1.0941983780411728,0.12987432229018503,0.49630179629464927,0.3042541529319487,0.6829616541185445,0.16560367973314677,5674]
["High","O94901-1","SUN domain-containing protein 1 [OS=Homo sapiens]",28,15,51,14,812,90,7.08,133.9,"","","","","","","","",1877.9,1912,1973.9,1698.3,1756.3,1761.3,1.1050441917981557,0.14410406555626531,0.006186781290974928,2.208535236461267,0.04959588123196328,1.3045543886812472,974]
["High","O94903","Pyridoxal phosphate homeostasis protein [OS=Homo sapiens]",42,11,47,11,275,30.3,7.5,93.29,"","cytosol;other cell component","other molecular function","PLPBP","ENSG00000147471","","","",2372.5,2347.7,2474,2115.7,2138,2148,1.1237952418888733,0.16837919710557034,2.6733832096158547E-3,2.57293878389477,0.031674925797694375,1.4992843938301446,659]
["High","O94905-1","Erlin-2 [OS=Homo sapiens]",52,18,80,15,339,37.8,5.62,160.07,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ERLIN2","ENSG00000147475; ENSGGOG00000012855; ENSPPAG00000034728; ENSPTRG00000020158","","ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions","",3355,3589.5,3418.9,3332.9,3695.8,3558.8,0.9788335301062574,-0.030864572863721684,0.5876108163188233,0.23091021862659836,0.7504195704640778,0.12469584835803303,6114]
["High","O94906-1","Pre-mRNA-processing factor 6 [OS=Homo sapiens]",48,43,144,43,941,106.9,8.25,301.32,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PRPF6","ENSG00000101161; ENSGGOG00000016876; ENSPPAG00000008686; ENSPTRG00000013765","mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",5927.2,5690.1,5796.5,5843.1,5738.8,5869.5,0.9978454450645791,-0.003111719110581255,0.882119445349794,0.0544726042740104,0.9369594108680712,0.028279222364976774,7351]
["High","O94913","Pre-mRNA cleavage complex 2 protein Pcf11 [OS=Homo sapiens]",10,12,21,12,1555,172.9,8.48,42.05,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCF11","ENSG00000165494","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",806.9,721.8,752.5,858.9,815.9,786.3,0.9269026045264313,-0.10951034109448637,0.13976321125319272,0.8546071293937596,0.31475949047156876,0.5020211663915208,3467]
["High","O94915-1","protein furry homolog-like [OS=Homo sapiens]",4,9,9,9,3013,339.4,5.58,17.4,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","","FRYL","ENSG00000075539","","","",374.4,405.7,401.1,361.3,360.6,395,1.0575700599874651,0.08075323956128498,0.22544986785587173,0.6469500149126669,0.4212281809568429,0.37548258139765744,4179]
["High","O94916","nuclear factor of activated T-cells 5 [OS=Homo sapiens]",2,4,5,4,1531,165.7,5.24,8.46,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFAT5","ENSG00000102908","Cancer immunotherapy by PD-1 blockade","","",369.9,380.6,356.2,384.6,382,405.2,0.9444444444444446,-0.08246216019197265,0.10012178217539873,0.9994714285199382,0.2559760560659834,0.5918006565817052,3054]
["High","O94919","endonuclease domain-containing 1 protein [OS=Homo sapiens]",21,6,10,6,500,55,5.71,10.9,"other metabolic processes","non-structural extracellular;cytosol","nucleic acid binding activity;other molecular function","ENDOD1","ENSG00000149218","","Platelet degranulation","",153.2,140.1,131.1,138.4,131.8,140.9,1.0323522257358306,0.04593528435082724,0.5591359355216781,0.2524825948505342,0.7317689213129839,0.13562603921794275,5966]
["High","O94921-1","Cyclin-dependent kinase 14 [OS=Homo sapiens]",4,2,3,1,469,53,8.92,4.72,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CDK14","ENSCATG00000032271; ENSCSAG00000012501; ENSG00000058091; ENSGGOG00000003585; ENSMLEG00000038830; ENSMNEG00000032203; ENSPANG00000022338","","","Transcriptional misregulation in cancer",22.5,17.2,10.8,26.2,16.7,21.9,0.779320987654321,-0.3597104252454676,0.3354166488380443,0.47441538442807796,0.5368866736628639,0.2701173757471543,4878]
["High","O94923","D-glucuronyl C5-epimerase [OS=Homo sapiens]",2,1,2,1,617,70.1,8.97,0,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GLCE","ENSG00000138604","","HS-GAG biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",41.4,37.9,42,24.2,29,24.9,1.553137003841229,0.6351850969785309,1.8582528087078079E-3,2.7308952020980626,0.028173277534738958,1.5501626264806183,515]
["High","O94925-1","Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",27,17,56,1,669,73.4,7.77,116.85,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","GLS","ENSG00000115419; ENSGGOG00000007590; ENSPTRG00000012747","Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling","Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer",52.6,62.9,72,40.8,38.3,39.9,1.5756302521008405,0.6559290220752999,0.015599734864432321,1.8068827829207,0.0831417950999915,1.080180602952193,1465]
["High","O94925-3","Isoform 3 of Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",36,19,69,3,598,65.4,7.88,154.85,"","","","GLS","","","","",2976.4,2943.2,3038.9,2717.2,2686.9,2851.2,1.0851816408852495,0.117936545408555,0.01536484014734502,1.8134719536950814,0.08267999439729146,1.082599561474182,1451]
["High","O94927","HAUS augmin-like complex subunit 5 [OS=Homo sapiens]",8,4,6,4,633,71.6,8.51,17.88,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","","HAUS5","ENSG00000249115","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",212.4,224.2,207.2,208.5,209.5,215.6,1.0160984848484846,0.023040241398068168,0.5697133140487032,0.24434363107813026,0.7389238465269559,0.1314003176773194,6020]
["High","O94941-1","RING finger protein 37 [OS=Homo sapiens]",3,1,4,1,541,58.9,7.56,12.27,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","UBOX5","ENSG00000185019","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",72.4,76,87.8,68.9,62.4,73.4,1.1538837322911577,0.20649786237374654,0.13620551550959653,0.865805305735398,0.30915484450550285,0.5098239436482928,3440]
["High","O94952-1","Isoform 2 of F-box only protein 21 [OS=Homo sapiens]",12,6,7,6,621,71.4,6.01,18.46,"","","","FBXO21","","","","",441.8,491.5,416.5,276.4,355.3,303,1.4440997111372633,0.5301703598129073,0.01237565045328803,1.9074319656590457,0.07276286049644047,1.138090236032409,1328]
["High","O94953","lysine-specific demethylase 4B [OS=Homo sapiens]",17,12,19,12,1096,121.8,7.09,55.62,"cell organization and biogenesis;protein metabolism;other metabolic processes","nucleus","other molecular function","KDM4B","ENSG00000127663","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Estrogen-dependent gene expression; HDMs demethylate histones","",1074.7,949.4,1101.3,957.2,877,965.8,1.1162142857142856,0.15861401575216721,0.1184406434370753,0.9264992419411966,0.28341542873327735,0.5475765110704361,3263]
["High","O94964-2","Isoform 2 of Protein SOGA1 [OS=Homo sapiens]",11,17,21,14,1661,183.7,6.52,48.57,"","","","SOGA1","","","","",761.9,740.2,802,917.5,873.1,877.1,0.863702815159126,-0.21139310292667252,6.2089119434654595E-3,2.2069844993967656,0.04972224046623416,1.3034493104366671,975]
["High","O94966-6","Isoform 6 of Ubiquitin carboxyl-terminal hydrolase 19 [OS=Homo sapiens]",18,15,26,15,1384,151.8,6.42,56.32,"","","","USP19","","","","",737.1,766.7,753.8,770.9,721.1,705.1,1.0275362978471623,0.039189358188373824,0.4030643230432775,0.3946256414181452,0.6012851039973081,0.22091955506337202,5234]
["High","O94967-1","WD repeat-containing protein 47 [OS=Homo sapiens]",3,3,4,3,919,101.9,5.94,7.7,"","cytoskeleton;other cell component","","WDR47","ENSG00000085433","","","",291.3,252.1,280.5,196.9,226.1,212.3,1.2968676215960964,0.37503122329526006,0.012049829768545546,1.919019088450402,0.07215112793926658,1.1417568751876679,1304]
["High","O94973","AP-2 complex subunit alpha-2 [OS=Homo sapiens]",28,21,51,12,939,103.9,6.96,100.25,"transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","AP2A2","ENSG00000183020","Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission","Neutrophil degranulation; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; Potential therapeutics for SARS; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease",955.9,1005.9,955.6,891.6,963.9,937.4,1.044577321064127,0.06291928664829631,0.19820645519942814,0.7028822054923219,0.38943029748292274,0.4095702636074829,3974]
["High","O94979","Protein transport protein Sec31A [OS=Homo sapiens]",21,23,58,23,1220,132.9,6.89,119.61,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC31A","ENSG00000138674","Sterol regulatory element-binding proteins (SREBP) signaling","COPII-mediated vesicle transport; Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; XBP1(S) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum",2549.3,2599.2,2507.8,2404.2,2639.6,2585.2,1.00357845064884,0.005153397904530513,0.9103495455621964,0.04079182024945743,0.9529439940675197,0.020932622742751667,7459]
["Low","O94983","Calmodulin-binding transcription activator 2 [OS=Homo sapiens]",1,1,1,1,1202,131.4,7.3,0,"stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CAMTA2","ENSG00000108509","","","",25.8,30.4,31.5,27.3,30.1,25.8,1.0540865384615385,0.07599331430364101,0.5243614691068975,0.2803692284408649,0.704078134271136,0.15237914284669676,5815]
["High","O94985-1","Calsyntenin-1 [OS=Homo sapiens]",1,1,2,1,981,109.7,4.91,2.37,"cell adhesion;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CLSTN1","ENSG00000171603","Splicing factor NOVA regulated synaptic proteins","","",43.4,41.9,44.6,42.7,42.5,41.3,1.0268774703557313,0.038264045866208705,0.27415163887976646,0.5620091535583167,0.4744184389125037,0.32383843987496713,4512]
["High","O94986-1","Isoform 1 of Centrosomal protein of 152 kDa [OS=Homo sapiens]",5,4,4,4,1275,147.3,5.43,4.51,"","","","CEP152","","","","",41.3,56.5,37.7,38.7,39.1,40.5,1.1453930684699913,0.19584277790144525,0.3778977870641694,0.4226256512653988,0.5795768849729,0.2368889436441017,5091]
["High","O94992","Protein HEXIM1 [OS=Homo sapiens]",13,4,5,4,359,40.6,4.89,3.94,"stress response;developmental processes;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","HEXIM1","ENSG00000186834","Initiation of transcription and translation elongation at the HIV-1 LTR","","",324,280.5,214,400.8,219.9,171.1,1.0337206365243747,0.04784634933141892,0.913374698380047,0.03935102306197522,0.9540641665486833,0.02042241539980705,7475]
["High","O95049-1","Tight junction protein ZO-3 [OS=Homo sapiens]",3,2,2,2,919,101.3,6.76,5.46,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","TJP3","ENSG00000105289","1q21.1 copy number variation syndrome","","Tight junction",74.9,77.6,69.2,89.8,80.4,89.3,0.8543352601156068,-0.22712576837793633,0.03273719616802588,1.484958519209311,0.12909698367674044,0.8890839048122068,1980]
["High","O95057","GTP-binding protein Di-Ras1 [OS=Homo sapiens]",11,2,2,2,198,22.3,8.72,5.66,"signal transduction","plasma membrane;other membranes","other molecular function","DIRAS1","ENSG00000176490","","","",72,84.7,76.6,103.7,92.6,92.4,0.8081052996189815,-0.30738480025178294,0.02473193510157893,1.606741901792406,0.10940903641537014,0.9609468068576119,1765]
["High","O95059","Ribonuclease P protein subunit p14 [OS=Homo sapiens]",16,1,2,1,124,13.7,7.75,3.51,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP14","ENSG00000163684","","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","",15.2,15.3,15.2,10.9,18,14.8,1.0457665903890159,0.06456088555747114,0.761680464271043,0.11822718313326366,0.868331298733874,0.06131454468452598,6849]
["High","O95067","G2/mitotic-specific cyclin-B2 [OS=Homo sapiens]",26,8,14,8,398,45.3,8.9,33.23,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","CCNB2","ENSG00000157456","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response","Resolution of Sister Chromatid Cohesion; Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint","FoxO signaling pathway; Cell cycle; Oocyte meiosis; p53 signaling pathway; Cellular senescence; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection",871.3,898.4,797.6,657.5,732.3,703.8,1.2262609858616735,0.2942660613596298,0.01318643588680897,1.8798725724489018,0.07553902524152929,1.12182862362494,1363]
["High","O95071","E3 ubiquitin-protein ligase UBR5 [OS=Homo sapiens]",18,35,63,35,2799,309.2,5.85,149.28,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBR5","ENSG00000104517","Mesodermal commitment pathway","","Ubiquitin mediated proteolysis",2172,2190.6,2183.9,2257.1,2340.5,2335.7,0.9442112702464915,-0.08281839161958829,0.009480376767538592,2.0231744026607217,0.06364813568438636,1.196214312730535,1163]
["High","O95104","Splicing factor, arginine/serine-rich 15 [OS=Homo sapiens]",20,22,77,19,1147,125.8,9.55,162.91,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SCAF4","ENSG00000156304","","","",3362.9,3277.7,3351.2,3268.7,3307.3,3292.8,1.0124635214007782,0.017869929288860636,0.22956545904886355,0.6390934563130889,0.42495189764189817,0.3716602270579211,4218]
["High","O95125","Zinc finger protein 202 [OS=Homo sapiens]",3,2,4,1,648,74.7,5.97,8.5,"other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF202","ENSG00000166261","","Generic Transcription Pathway","",83.4,68.4,82.5,84.8,93.5,89.5,0.874906646751307,-0.1927990064611749,0.11072036592051755,0.955772487582052,0.27185679783251604,0.5656598029078493,3180]
["High","O95139","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [OS=Homo sapiens]",20,2,4,2,128,15.5,9.63,9.65,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB6","ENSG00000165264","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",53.5,51.5,63,53.6,40.1,58.7,1.1023622047244093,0.14059833017280038,0.4739477572958455,0.3242695274579053,0.6637818993660918,0.17797459451946818,5575]
["High","O95140","Mitofusin-2 [OS=Homo sapiens]",17,11,15,11,757,86.3,6.98,31.41,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion","other molecular function","MFN2","ENSG00000116688","Intracellular trafficking proteins involved in CMT neuropathy","Factors involved in megakaryocyte development and platelet production; PINK1-PRKN Mediated Mitophagy; RHOT2 GTPase cycle","Mitophagy; NOD-like receptor signaling pathway; Parkinson disease; Pathways of neurodegeneration",545.5,625.4,525.3,492.6,553.4,520.6,1.0827269245499809,0.1146694255183335,0.28762035578031053,0.5411803808405284,0.4884166459183699,0.3112095431151532,4598]
["High","O95149","Snurportin-1 [OS=Homo sapiens]",8,3,5,3,360,41.1,6.64,11.4,"transport","cytosol;nucleus","nucleic acid binding activity;other molecular function","SNUPN","ENSG00000169371","","snRNP Assembly","Nucleocytoplasmic transport",398.6,422.8,379.2,419.4,466.9,440.7,0.9047475508666166,-0.14441279763065804,0.0867356737798462,1.0618022434784309,0.23433638092492703,0.6301602815763434,2890]
["High","O95155","Ubiquitin conjugation factor E4 B [OS=Homo sapiens]",26,26,68,24,1302,146.1,6.55,144.91,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","UBE4B","ENSG00000130939","","","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",2526.4,2409.5,2538.9,2469,2533.5,2471.8,1.0000668958966057,9.6507150358661939E-5,0.9972986399334376,1.1747732286459059E-3,0.9994747504300193,2.2817291897566023E-4,7791]
["High","O95159","Zinc finger protein-like 1 [OS=Homo sapiens]",19,4,10,4,310,34.1,8.07,28.64,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","ZFPL1","ENSG00000162300","","","",699.7,679.3,713,750.2,733.5,744.8,0.9387480367960511,-0.091190109365713,0.014268823278124487,1.84561184082292,0.07923966725149076,1.1010573568480897,1406]
["High","O95163","Elongator complex protein 1 [OS=Homo sapiens]",27,25,68,25,1332,150.2,5.94,159.43,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","ELP1","ENSG00000070061","","HATs acetylate histones","",2244.9,2177.2,2252.7,2154.8,2329.8,2274.4,0.9875425358780885,-0.01808520495961573,0.6478605101418444,0.1885184913467974,0.7946111943429974,0.09984532097314629,6366]
["High","O95166","Gamma-aminobutyric acid receptor-associated protein [OS=Homo sapiens]",12,2,4,1,117,13.9,8.79,3.78,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAP","ENSG00000170296","","Macroautophagy; TBC/RABGAPs","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse",214.5,250.3,165.5,273.4,210.9,213.7,0.9030085959885387,-0.14718837370281249,0.5187198763986404,0.2850671103159152,0.7007205527544262,0.1544551440778089,5780]
["High","O95169","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [OS=Homo sapiens]",18,3,8,3,186,21.8,6.8,10.96,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;ER/Golgi","transporter activity","NDUFB8","ENSG00000166136","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Mitochondrial protein import; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",402.3,411.3,405.3,413.8,405.8,419.7,0.9835390946502058,-0.02394569562503224,0.2310585043548009,0.6362780421792875,0.4266031690712427,0.3699759226675525,4229]
["Low","O95183","vesicle-associated membrane protein 5 [OS=Homo sapiens]",6,1,1,1,116,12.8,7.85,2.25,"transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP5","ENSG00000168899","","","SNARE interactions in vesicular transport",149.8,126.5,133.3,116.2,112.7,125.5,1.1557562076749437,0.20883711144498188,0.08038294857815569,1.0948360672191788,0.22415359374937127,0.6494542939027628,2800]
["High","O95197","Reticulon-3 [OS=Homo sapiens]",4,4,12,3,1032,112.5,4.96,24.88,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","RTN3","ENSG00000133318","Alzheimer's disease and miRNA effects; Alzheimer's disease","Synaptic adhesion-like molecules","Alzheimer disease",925.6,965.5,871.6,715.8,819.4,833.5,1.166335964875248,0.2219834189365039,0.04619751804681798,1.3353813562085006,0.1604582833227557,0.7946378584468887,2248]
["High","O95202-1","mitochondrial proton/calcium exchanger protein [OS=Homo sapiens]",41,30,98,30,739,83.3,6.7,215.37,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;translation activity;other molecular function","LETM1","ENSG00000168924","","RHOG GTPase cycle; Mitochondrial calcium ion transport","",4290.7,4250.1,4127.6,4553.5,4254,4415.7,0.9580434388045254,-0.06183702397067936,0.13652489090498696,0.864788161830552,0.3096097438821197,0.5091853798765901,3443]
["High","O95208-1","epsin-2 [OS=Homo sapiens]",7,4,5,4,641,68.4,7.52,11.18,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","EPN2","ENSG00000072134","","Cargo recognition for clathrin-mediated endocytosis","Endocytosis",231.8,250.5,231.5,215.4,215.3,201.5,1.129073078139829,0.17513886614452406,0.025162479375041534,1.5992465680818015,0.110873949751876,0.9551704809741982,1772]
["High","O95210","Starch-binding domain-containing protein 1 [OS=Homo sapiens]",4,2,2,2,358,39,5.73,4.4,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STBD1","ENSG00000118804","Exercise-induced circadian regulation","Neutrophil degranulation; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","",145,146.2,137.9,159.3,159.7,147,0.9208154506437768,-0.11901605379325703,0.06630903868324622,1.1784272682362016,0.19966871347427168,0.6996899803469177,2593]
["High","O95218-1","Zinc finger Ran-binding domain-containing protein 2 [OS=Homo sapiens]",42,19,63,19,330,37.4,10.01,123.1,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRANB2","ENSANAG00000018241; ENSCANG00000036472; ENSCATG00000025001; ENSG00000132485; ENSGGOG00000023501; ENSMFAG00000003326; ENSMLEG00000036639; ENSMNEG00000042080; ENSNLEG00000009455; ENSPANG00000013398; ENSPPAG00000037049; ENSPTRG00000000856; ENSSBOG00000013268","","","",2788.3,2739,2834.9,3516.6,3316.7,3410,0.8163580096258043,-0.29272611739494664,6.0990529819902255E-4,3.214737593944143,0.017703124789360477,1.7519500692879155,269]
["High","O95219","sorting nexin-4 [OS=Homo sapiens]",26,9,22,9,450,51.9,5.99,41.35,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX4","ENSG00000114520","","","Endocytosis",730.3,730.5,764.9,788.6,781,754.3,0.9577434485132752,-0.06228884302414908,0.10236954910739336,0.9898292095842015,0.25926092748314217,0.5862629296520745,3083]
["High","O95229","ZW10 interactor [OS=Homo sapiens]",12,3,4,3,277,31.3,5.15,8.19,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","ZWINT","ENSG00000122952","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",144.3,165.6,167.6,169.8,138.3,148.9,1.0448577680525162,0.06330656786504102,0.596075536739018,0.22469870148416696,0.756650591913226,0.12110462384927925,6151]
["High","O95232-1","Luc7-like protein 3 [OS=Homo sapiens]",50,23,92,23,432,51.4,9.79,185.6,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","LUC7L3","ENSCANG00000028098; ENSCATG00000034891; ENSG00000108848; ENSGGOG00000024399; ENSMLEG00000034172; ENSMMUG00000010117; ENSPPAG00000025115; ENSPTRG00000009409; ENSRROG00000039925","","","",5522.2,5033.3,5549.2,5538.8,5307.7,5487.4,0.9859678337690325,-0.02038751402339327,0.6957405831009833,0.15755266316130243,0.8260861424654011,0.08297466303466099,6576]
["High","O95235","kinesin-like protein KIF20A [OS=Homo sapiens]",20,15,33,15,890,100.2,6.92,63.4,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF20A","ENSG00000112984","","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Mitotic Telophase/Cytokinesis","",1129.9,1104,1112.3,971.8,978.6,949,1.1541008484514035,0.20676929608367767,2.2427137232267574E-4,3.649226159478862,0.011912318878200354,1.9240036895684027,147]
["High","O95237","lecithin retinol acyltransferase [OS=Homo sapiens]",23,4,9,4,230,25.7,7.46,16.73,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LRAT","ENSG00000121207","Vitamin A and carotenoid metabolism","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events","Retinol metabolism; Metabolic pathways; Vitamin digestion and absorption",412.9,441.3,453.5,293.6,299.7,306.4,1.4534844948316108,0.5395156814852575,4.1558921462239213E-4,3.381335731785601,0.015675944868462018,1.8047662725838831,207]
["High","O95239-1","Chromosome-associated kinesin KIF4A [OS=Homo sapiens]",48,55,162,55,1232,139.8,6.27,329.66,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","KIF4A","ENSG00000090889; ENSGGOG00000006631; ENSPTRG00000021996","Retinoblastoma gene in cancer","MHC class II antigen presentation; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",7154,6867.2,7212.1,6658,6389.5,6713.3,1.074516213918465,0.1036872524848933,0.02835847684139843,1.5473170991991354,0.11923693439829777,0.9235891982802804,1857]
["High","O95243-2","Isoform 2 of Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",9,5,6,5,574,65.3,8.84,2.68,"","","","MBD4","","","","",228.4,244.6,216.1,212.8,211.7,205.5,1.0938095238095238,0.12936152882443883,0.08281086398566337,1.0819126842353803,0.22799267489423822,0.6420791060877739,2836]
["High","O95248-1","Myotubularin-related protein 5 [OS=Homo sapiens]",4,6,7,6,1867,208.2,6.9,14.6,"","","","","","","","",252.5,254.6,274.9,252.5,268.1,233.1,1.03754809605944,0.05317821485778819,0.48883525917543313,0.3108374764294479,0.6771023068372861,0.1693457065910006,5637]
["High","O95249-1","Golgi SNAP receptor complex member 1 [OS=Homo sapiens]",27,8,14,8,250,28.6,9.42,28.62,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","GOSR1","ENSG00000108587","","Intra-Golgi traffic; COPI-mediated anterograde transport","SNARE interactions in vesicular transport",588.5,635,626.7,700,635.7,618.8,0.9466359682783321,-0.07911835528421152,0.2906943100439611,0.5365634688855551,0.4921381554256826,0.30791296284958114,4612]
["High","O95251-1","Histone acetyltransferase KAT7 [OS=Homo sapiens]",17,11,25,11,611,70.6,8.85,39.46,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KAT7","ENSAMEG00000012243; ENSANAG00000032052; ENSCANG00000040077; ENSCATG00000030056; ENSCJAG00000007037; ENSDLEG00000005028; ENSECAG00000010150; ENSG00000136504; ENSGGOG00000007469; ENSMLEG00000043692; ENSMNEG00000044419; ENSPANG00000022824; ENSPCTG00005022544; ENSPPAG00000041097; ENSPPYG00000008925; ENSPTRG00000009383; ENSRFEG00010021504","Androgen receptor signaling pathway; Androgen receptor signaling pathway","HATs acetylate histones","",934.9,880.8,970.2,976.4,1062.2,1064.2,0.8978664432125821,-0.15542723348974422,0.05323857354064114,1.2737735894056184,0.17502601356013728,0.7568973987078682,2375]
["Low","O95259","Potassium voltage-gated channel subfamily H member 1 [OS=Homo sapiens]",1,1,1,1,989,111.4,7.58,1.63,"transport;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","KCNH1","ENSG00000143473","","Voltage gated Potassium channels","",62.2,75.8,56.1,43.8,67.7,58,1.145132743362832,0.19551484468995767,0.4165657938846234,0.3803163948229014,0.6141513819205323,0.21172456659590957,5296]
["High","O95260-2","Isoform ATE1-2 of Arginyl-tRNA--protein transferase 1 [OS=Homo sapiens]",22,7,9,7,518,59,7.02,16.14,"","","","ATE1","","","","",212.7,193.3,213.5,242.3,241.5,231.2,0.8664335664335664,-0.2068389595251503,0.013271442424757586,1.8770818726842486,0.07574811582785616,1.1206281654097106,1368]
["High","O95271","Tankyrase-1 [OS=Homo sapiens]",1,2,3,2,1327,142,7.05,4.3,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","TNKS","ENSG00000173273","NAD+ biosynthetic pathways; Regulation of Wnt / B-catenin signaling by small molecule compounds","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; XAV939 stabilizes AXIN","",66.9,76.1,62.1,77.1,92.4,77.3,{"$f":"AVERAGE(T834:V834)/AVERAGE(W834:Y834)","v":0.8310372771474878},{"$f":"LOG(Z834,2)","v":-0.26701490266956607},{"$f":"TTEST(T834:V834,W834:Y834,2,2)","v":0.1000929235346954},{"$f":"-LOG10(AB834)","v":0.9995966256022907},{"$f":"AB834*7808/AF834","v":0.2559860946475276},{"$f":"-LOG10(AD834)","v":0.5917836252423171},3053]
["High","O95273-1","Cyclin-D1-binding protein 1 [OS=Homo sapiens]",9,4,10,4,360,40.2,4.82,21.8,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","","CCNDBP1","ENSG00000166946","","","",737,776.4,797.9,670.2,635.1,635.8,1.1907166039874297,0.2518300860209611,0.004386171101238259,2.357914430826702,0.0409166355537256,1.3881000841613267,837]
["High","O95292","Vesicle-associated membrane protein-associated protein B/C [OS=Homo sapiens]",48,11,35,10,243,27.2,7.3,61.69,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAPB","ENSG00000124164","Ciliary landscape","RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle; Sphingolipid de novo biosynthesis","Cholesterol metabolism; Amyotrophic lateral sclerosis; Pathways of neurodegeneration",1774.7,1820.1,1942.7,2107.3,2035.8,1891.1,0.9176858572801695,-0.12392772088563662,0.11044789825420177,0.9568425440323581,0.2712731014686403,0.5665932672884957,3179]
["Medium","O95294-1","RasGAP-activating-like protein 1 [OS=Homo sapiens]",1,1,1,1,804,90,6.51,0,"signal transduction;other biological processes","cytosol","enzyme regulator activity;other molecular function","RASAL1","ENSG00000111344","Ras signaling","Regulation of RAS by GAPs","Ras signaling pathway",12.1,11.3,15.9,15.3,15.1,16.3,0.8415417558886509,-0.24889323745105563,0.16789636127256216,0.7749587159904298,0.3524018249505821,0.45296185121369187,3720]
["High","O95295","SNARE-associated protein Snapin [OS=Homo sapiens]",14,2,4,2,136,14.9,9.31,7.34,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SNAPIN","ENSG00000143553","","Golgi Associated Vesicle Biogenesis","",91.7,110.7,90.2,86.7,72.1,77.8,1.2366863905325445,0.30647969579869855,0.07608640781158088,1.1186929193090258,0.21666034726215302,0.6642205651038842,2742]
["High","O95297-1","Myelin protein zero-like protein 1 [OS=Homo sapiens]",13,3,6,3,269,29.1,8.72,11.85,"cell-cell signaling;signal transduction","plasma membrane;other membranes","other molecular function","MPZL1","ENSG00000197965","","","Cell adhesion molecules",162.1,159.5,159.4,224.5,192.4,215.4,0.7607148505456272,-0.3945723255165913,0.006264738048889996,2.203097083696169,0.049862461453346676,1.3022262864174825,981]
["High","O95298-1","NADH dehydrogenase [ubiquinone] 1 subunit C2 [OS=Homo sapiens]",24,4,14,4,119,14.2,8.98,25.51,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","NDUFC2","ENSG00000151366; ENSGGOG00000041901","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Neutrophil degranulation; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",944,999.7,911.2,826.7,979.9,968.8,1.028644519708871,0.04074449995922881,0.6589267793620932,0.18116284198524027,0.8026365512104874,0.09548106684542225,6410]
["High","O95299","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [OS=Homo sapiens]",22,7,18,7,355,40.7,8.48,37.43,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity","NDUFA10","ENSG00000130414","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",888.5,897.3,850.9,883.9,964.7,927.4,0.9498198847262247,-0.07427413517919318,0.1646915945675735,0.7833285655301458,0.3495275809686366,0.45651854870263747,3679]
["High","O95302","Peptidyl-prolyl cis-trans isomerase FKBP9 [OS=Homo sapiens]",7,5,8,4,570,63,5.08,9.64,"protein metabolism;other metabolic processes;other biological processes","ER/Golgi","other molecular function","FKBP9","ENSG00000122642","","Association of TriC/CCT with target proteins during biosynthesis","",253.5,263,268.8,293.1,258,268.5,0.958150317227916,-0.06167608724799338,0.3695158739964735,0.43236690005401884,0.5717756528268857,0.24277434157693925,5046]
["High","O95336","6-phosphogluconolactonase [OS=Homo sapiens]",52,10,57,10,258,27.5,6.05,133.7,"other metabolic processes","cytosol;other cell component","other molecular function","PGLS","ENSG00000130313","Pentose phosphate metabolism","Pentose phosphate pathway","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism",2183.5,2234.2,2130.4,2114.8,2231.7,2194.6,1.0010701563957134,1.5430838017588843E-3,0.96171829820764,0.016952120737712097,0.9818379278772559,0.007960195347120363,7648]
["High","O95340","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [OS=Homo sapiens]",16,9,11,8,614,69.5,8.03,20.58,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS2","ENSG00000198682","RANKL/RANK signaling pathway; Proteoglycan biosynthesis; Sulfation biotransformation reaction","Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Defective PAPSS2 causes SEMD-PA","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways",517.3,497,507.4,503.3,510.2,512.7,0.9970515004586554,-4.260069163202279E-3,0.8288146412566505,0.08154258559014567,0.9087747112669466,0.04154376670130914,7121]
["High","O95347-1","structural maintenance of chromosomes protein 2 [OS=Homo sapiens]",51,64,194,64,1197,135.6,8.43,396.49,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC2; SMC2L1","ENSG00000136824","Retinoblastoma gene in cancer","Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes","",8397.2,7990.4,8298.6,9143.2,9029.4,9191.8,0.9021283126982502,-0.14859544751758538,2.4673779359978714E-3,2.6077643231705108,0.030824459078834205,1.5111045358559507,625]
["High","O95352","Ubiquitin-like modifier-activating enzyme ATG7 [OS=Homo sapiens]",6,4,5,4,703,77.9,6.24,8.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","other molecular function","ATG7","ENSG00000197548","Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy","Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Macroautophagy","Autophagy; Autophagy; Ferroptosis; Neutrophil extracellular trap formation",302.8,319.9,325.9,342.9,338.6,327.7,0.9399524375743161,-0.0893403378967737,0.07095782013353064,1.1489997347563812,0.20812872261555493,0.6816679812364022,2662]
["High","O95359-3","Isoform 3 of Transforming acidic coiled-coil-containing protein 2 [OS=Homo sapiens]",8,15,28,12,2871,300.9,4.78,64.6,"","","","TACC2","","","","",546.5,445.8,556.4,559.7,498.1,494.1,0.9979380114698109,-0.002977891872521565,0.9805950297991656,0.008510312330169583,0.9902335738065035,0.004262353028049591,7732]
["High","O95363","phenylalanine--tRNA ligase, mitochondrial [OS=Homo sapiens]",8,4,5,4,451,52.3,7.46,10.62,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","FARS2","ENSG00000145982","","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",196.9,220.3,199.7,196.3,228.2,197.8,0.9913225132572716,-0.012573599956849734,0.8945130808211247,0.048413304188955016,0.9442149702651537,0.024929118232227546,7397]
["High","O95365","Zinc finger and BTB domain-containing protein 7A [OS=Homo sapiens]",4,1,2,1,584,61.4,5.19,7.63,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB7A","ENSG00000178951","IL-18 signaling pathway","","",18.8,17.8,14.7,13.4,13.8,14.8,1.2214285714285713,0.28856949794093123,0.07599539362923492,1.1192127311670148,0.21663820133518302,0.6642649587623407,2739]
["High","O95372","acyl-protein thioesterase 2 [OS=Homo sapiens]",29,5,19,5,231,24.7,7.23,45.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;other cell component","other molecular function","LYPLA2","ENSG00000011009","","L1CAM interactions","Glycerophospholipid metabolism",654.5,645.7,691.2,679,649.8,646.8,1.0079975703583723,0.011492161421012163,0.7760969097367619,0.11008404583443436,0.8759416986447871,0.057524798854141614,6918]
["High","O95373","Importin-7 [OS=Homo sapiens]",43,36,155,35,1038,119.4,4.82,339.8,"stress response;transport;signal transduction;other biological processes","cytosol;nucleus","transporter activity;enzyme regulator activity;other molecular function","IPO7","ENSG00000205339","","","Nucleocytoplasmic transport",5680.6,5772.7,5679.1,4995.4,5451,5335,1.0856071071007642,0.11850207073442401,0.03249539702385322,1.4881781525201043,0.12853295844085408,0.8909854961950867,1974]
["High","O95376","E3 ubiquitin-protein ligase ARIH2 [OS=Homo sapiens]",31,11,24,11,493,57.8,5.63,55.14,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","ARIH2","ENSG00000177479","Modulators of TCR signaling and T cell activation","Antigen processing: Ubiquitination & Proteasome degradation","",493.3,516.6,488.1,561.3,489.7,563.2,0.9280138768430181,-0.10778171636326281,0.2066522367903832,0.6847598895815799,0.39978708247257483,0.3981712424878173,4036]
["High","O95379","Tumor necrosis factor alpha-induced protein 8 [OS=Homo sapiens]",19,3,6,3,198,23,7.93,13.26,"other biological processes","nucleus;other cell component","enzyme regulator activity","TNFAIP8","ENSG00000145779","","PI Metabolism","",75.7,85.5,84.5,86.2,85.2,89.5,0.9417401303181296,-0.08659908645528713,0.20754292899480892,0.6828920584832372,0.4007159222530831,0.3971634007435652,4044]
["High","O95391","Pre-mRNA-splicing factor SLU7 [OS=Homo sapiens]",11,4,5,4,586,68.3,7.14,8.18,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLU7","ENSG00000164609","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","Spliceosome",77.9,83,85.7,69.6,76,70.5,1.141138361869505,0.190473727543332,0.02866999490184403,1.542572384280624,0.11996533772432916,0.9209442190324698,1866]
["High","O95394","phosphoacetylglucosamine mutase [OS=Homo sapiens]",32,16,28,16,542,59.8,6.25,48.67,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PGM3","ENSG00000013375","Glucuronidation","Synthesis of UDP-N-acetyl-glucosamine","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",1677,1644.6,1559.4,1649.7,1996,1772.8,0.9008028052043924,-0.15071677474257233,0.17012127621149614,0.7692413679664108,0.35582826805769135,0.44875955323408,3733]
["High","O95396","Adenylyltransferase and sulfurtransferase MOCS3 [OS=Homo sapiens]",15,7,12,7,460,49.6,6.21,29.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","MOCS3","ENSG00000124217","","Molybdenum cofactor biosynthesis","Sulfur relay system",364.3,337.5,375,371.7,343.1,355.2,1.0063551401869157,9.139518434445229E-3,0.8783329718528918,0.05634081390619383,0.9348451259851935,0.02926033190952309,7336]
["High","O95400","CD2 antigen cytoplasmic tail-binding protein 2 [OS=Homo sapiens]",40,7,25,7,341,37.6,4.61,49.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","CD2BP2","ENSG00000169217","mRNA processing; Ciliary landscape","mRNA Splicing - Major Pathway","",765.1,711.4,739.7,733.5,641,631.4,1.1048407198763646,0.14383839748295796,0.12379040346548965,0.907313021580239,0.2914823492938912,0.5353877387998395,3316]
["High","O95405-1","Zinc finger FYVE domain-containing protein 9 [OS=Homo sapiens]",2,1,1,1,1425,156.3,5.01,0,"transport;signal transduction","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ZFYVE9","ENSG00000157077","TGF-beta signaling pathway; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling","","Endocytosis; TGF-beta signaling pathway",25.9,19.1,14.3,29.5,27.6,29,0.6887340301974448,-0.5379811328508404,0.05895184698215844,1.2295025837564428,0.18658128140927974,0.7291319285875435,2467]
["High","O95409","Zinc finger protein ZIC 2 [OS=Homo sapiens]",6,3,6,2,532,55,8.41,13.67,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZIC2","ENSG00000043355","Mesodermal commitment pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Ciliopathies","","",159.7,164.4,146.7,156.5,165.6,135.8,1.0281720899759772,0.04008175536489697,0.6973293456726675,0.1565620580196092,0.8274692296371106,0.08224814697492931,6580]
["High","O95425","Supervillin [OS=Homo sapiens]",11,16,21,16,2214,247.6,6.98,37.41,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SVIL","ENSG00000197321","","","",502.7,502.6,498.1,607.3,565.4,576.8,0.8593312374964277,-0.2187137556296576,2.8717928688742765E-3,2.5418468872531834,0.03287823859262515,1.4830914572510268,682]
["High","O95427","GPI ethanolamine phosphate transferase 1 [OS=Homo sapiens]",2,2,2,2,931,105.7,8.65,4.32,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","PIGN","ENSG00000197563","","Synthesis of glycosylphosphatidylinositol (GPI)","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways",108.3,112.8,105.5,135.7,122.3,133.3,0.8346537183746486,-0.26075031933909926,0.009683251141183909,2.013978804301242,0.06401932676576118,1.193688897256121,1181]
["High","O95433","activator of 90 kDa heat shock protein ATPase homolog 1 [OS=Homo sapiens]",71,19,96,19,338,38.3,5.53,234.42,"other biological processes","cytosol;ER/Golgi","other molecular function","AHSA1","ENSG00000100591","T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection","","",4390.4,4354.7,4427.7,4538.1,4497.1,4653.8,0.9622908904960187,-0.055455023304428516,0.02869061064595247,1.5422602082076335,0.11992306634025529,0.9210972754430727,1868]
["Medium","O95452","Gap junction beta-6 protein [OS=Homo sapiens]",2,1,1,1,261,30.4,8.51,1.99,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","transporter activity;cytoskeletal activity","GJB6","ENSG00000121742","Calcium regulation in cardiac cells","Gap junction assembly","",52.5,68.6,65.1,77.9,83.8,76.6,0.7813680234997903,-0.35592587863147707,0.031806603210742974,1.497482708937281,0.1267718008522109,0.8969773402733819,1959]
["High","O95453","poly(A)-specific ribonuclease PARN [OS=Homo sapiens]",16,9,20,9,639,73.4,6.2,38.49,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARN","ENSG00000140694; ENSG00000274829","Lung fibrosis","Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA","RNA degradation",858.5,844.3,917.1,892.4,937.2,943.7,0.9446868351783074,-0.08209194144074843,0.13653850154714559,0.864744867658188,0.30955070269457396,0.5092682057811698,3444]
["High","O95456","Proteasome assembly chaperone 1 [OS=Homo sapiens]",46,10,26,10,288,32.8,7.17,55.54,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","PSMG1","ENSG00000183527","","","",1087.7,1184.1,1079.7,1062.8,1329.7,1216.8,0.9285734075859584,-0.10691212918115209,0.3657259954108994,0.4368441693795648,0.5672603440938225,0.24621757593327329,5034]
["Medium","O95460","matrilin-4 [OS=Homo sapiens]",2,1,1,1,622,68.4,6.1,0,"","non-structural extracellular;extracellular matrix","other molecular function","MATN4","ENSG00000124159","","ECM proteoglycans","",64.7,70.4,79.6,77.7,72.4,71.8,0.967552951780081,-0.04758747633823826,0.6384448931888156,0.19487658253031212,0.7896368962487362,0.10257256719903059,6313]
["High","O95470","sphingosine-1-phosphate lyase 1 [OS=Homo sapiens]",13,7,15,7,568,63.5,9.16,27.09,"other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","SGPL1","ENSG00000166224","Sphingolipid pathway; Kennedy pathway from sphingolipids; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",756.7,776.7,765,736.2,740.7,747.2,1.0334067712782697,0.0474082419986695,0.020118559834688517,1.696403111003464,0.09590092502396089,1.0181772037692285,1638]
["High","O95478","Ribosome biogenesis protein NSA2 homolog [OS=Homo sapiens]",24,5,21,5,260,30,10.27,29.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","NSA2","ENSG00000164346","","","",838,869.5,844.3,1005.1,1046.5,1039.8,0.8254512518599989,-0.27674507753982786,3.599770337793369E-4,3.4437252059578984,0.014871432167984458,1.8276472054725073,189]
["High","O95479","GDH/6PGL endoplasmic bifunctional protein [OS=Homo sapiens]",11,8,14,8,791,88.8,7.3,27.85,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","H6PD","ENSG00000049239","Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism","","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism",448.1,432.5,457.3,419.4,442.5,430.9,1.0348855198019802,0.04947118400603104,0.20134846139106077,0.6960516847152294,0.39293396314456447,0.4056804314355912,4001]
["High","O95486-1","Protein transport protein Sec24A [OS=Homo sapiens]",8,9,15,9,1093,119.7,7.66,32.26,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi","other molecular function","SEC24A","ENSG00000113615","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",545.8,557.6,552.2,497.4,547,565.2,1.0285785288270377,0.04065194342476347,0.49693989582822495,0.3036961353886649,0.6834783700240938,0.1652752249554423,5677]
["High","O95487-1","Protein transport protein Sec24B [OS=Homo sapiens]",8,9,13,9,1268,137.3,6.67,27.89,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SEC24B","ENSG00000138802","Sterol regulatory element-binding proteins (SREBP) signaling","COPII-mediated vesicle transport; MHC class II antigen presentation; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",416.1,422.4,414.7,429.1,424.3,434.8,0.9728303058531284,-0.03973992220887567,0.03875066191485019,1.4117208747444643,0.143873118512197,0.84202034277215,2103]
["High","O95490-1","Adhesion G protein-coupled receptor L2 [OS=Homo sapiens]",16,16,33,16,1459,163.2,6.43,61.6,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ADGRL2","ENSG00000117114","GPCRs, other; GPCRs, class B secretin-like","","",879.8,873.7,919.5,1017.3,929.9,936.5,0.9269341471026806,-0.10946124689210181,0.09002925760693557,1.0456163310899693,0.23999605441958108,0.6197958981129326,2929]
["High","O95502","neuronal pentraxin receptor [OS=Homo sapiens]",2,1,2,1,500,52.8,6.21,4.73,"other biological processes","other membranes;other cell component","other molecular function","NPTXR","ENSG00000221890","","","",59.9,68,60.2,56.2,38.7,53.2,1.2700877785280216,0.34492820823434733,0.09108444662866978,1.0405557758263775,0.24157179323255898,0.6169537768332033,2944]
["High","O95528","Solute carrier family 2, facilitated glucose transporter member 10 [OS=Homo sapiens]",4,2,2,2,541,56.9,8.59,2.24,"transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC2A10","ENSG00000197496","Nuclear receptors meta-pathway; NRF2 pathway","Cellular hexose transport; Defective SLC2A10 causes arterial tortuosity syndrome (ATS)","",26.3,23.2,19.4,19.9,20.8,21,1.1166936790923827,0.15923349355487373,0.301285796542425,0.5210213417041613,0.501800234514346,0.2994691400555602,4688]
["High","O95544","NAD kinase [OS=Homo sapiens]",4,1,2,1,446,49.2,6.47,2.77,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NADK","ENSG00000008130","NAD+ metabolism","Nicotinate metabolism","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors",35.6,37.1,33.3,28.8,45.5,43.1,0.9028960817717206,-0.1473681436594906,0.5151707037691361,0.2880488419859054,0.6977368352175914,0.1563083489579878,5765]
["High","O95551-1","Tyrosyl-DNA phosphodiesterase 2 [OS=Homo sapiens]",23,6,14,6,362,40.9,5.1,33.83,"DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TDP2","ENSG00000111802","Oxidative damage response","Nonhomologous End-Joining (NHEJ)","",423.1,388.2,412,513.2,530.2,495.5,0.7949184482422509,-0.3311212349324218,1.8496769195839983E-3,2.732904122567375,0.028097815930178717,1.551327436904015,514]
["High","O95562","Vesicle transport protein SFT2B [OS=Homo sapiens]",17,2,3,2,160,17.8,9.13,9.05,"transport","other membranes","","SFT2D2","ENSG00000213064","TYROBP causal network in microglia","","",84.9,87.8,77.1,109.4,96.1,94.4,0.8329443147715906,-0.2637080452607828,0.043217537277022995,1.3643399847334925,0.1538024298354583,0.8130368033135495,2194]
["Medium","O95563","Mitochondrial pyruvate carrier 2 [OS=Homo sapiens]",8,1,1,1,127,14.3,10.43,2,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MPC2","ENSG00000143158","Glycolysis and gluconeogenesis","Pyruvate metabolism","Diabetic cardiomyopathy",35.1,30.9,28.1,22.6,26.8,25.9,1.2496679946879146,0.32154485805660804,0.05946058591512532,1.2257708156414733,0.18750737270811732,0.7269816513309182,2476]
["Medium","O95568","histidine protein methyltransferase 1 homolog [OS=Homo sapiens]",3,1,1,1,372,42.1,6.76,2.2,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","METTL18","ENSG00000171806","","","",52.4,53.3,43.7,49.5,51.7,51.6,0.9777486910994762,-0.032464395246512,0.7367177291697795,0.13269887868867972,0.8534557907058811,0.06881897056536414,6740]
["High","O95571","Persulfide dioxygenase ETHE1, mitochondrial [OS=Homo sapiens]",12,2,4,2,254,27.9,6.83,12.38,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","ETHE1","ENSG00000105755","","Sulfide oxidation to sulfate","Sulfur metabolism; Metabolic pathways",106.1,121.9,115.8,101.4,81.5,101,1.2109897851356113,0.2761866957536696,0.06748101526601535,1.1708183919822719,0.20148824749409097,0.6957502805269297,2615]
["High","O95573","long-chain-fatty-acid--CoA ligase 3 [OS=Homo sapiens]",34,19,75,16,720,80.4,8.38,200.86,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL3","ENSG00000123983","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Ciliary landscape; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway",4024.7,4014.8,3994,3942.2,4325.7,4345,0.954062903852405,-0.0678437048786674,0.21578261245230615,0.6659835532594467,0.4101340404156783,0.38707418352605183,4108]
["High","O95602","DNA-directed RNA polymerase I subunit RPA1 [OS=Homo sapiens]",31,42,105,41,1720,194.7,7.03,243.35,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR1A","ENSG00000068654","Pyrimidine metabolism; Eukaryotic transcription initiation","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase",3809.1,3878.3,3824.4,3870.1,3882.4,3900.6,0.9878744711707613,-0.01760036413518886,0.10752187026872805,0.9685031899717605,0.26719629632661634,0.5731695660170797,3142]
["High","O95613","Pericentrin [OS=Homo sapiens]",12,29,38,29,3336,377.8,5.55,73.09,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton","other molecular function","PCNT","ENSG00000160299","","Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy","",1167.9,1141.8,1148.9,1280.9,1223.6,1264.8,0.9175709017589472,-0.1241084539190831,0.005253195044466056,2.2795764740945144,0.04527256833023286,1.3441648671126918,906]
["High","O95619","YEATS domain-containing protein 4 [OS=Homo sapiens]",30,7,12,7,227,26.5,8.41,24.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus","cytoskeletal activity;other molecular function","YEATS4","ENSG00000127337","","HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors","",574.6,605.2,623.4,731.2,729.4,697.6,0.8355110740431843,-0.25926914468431467,2.736116545343995E-3,2.5628654077114987,0.03202938228792491,1.4944514369694124,667]
["High","O95625","Zinc finger and BTB domain-containing protein 11 [OS=Homo sapiens]",6,6,6,6,1053,119.3,8.66,10.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB11","ENSG00000066422","","","",260.7,246.9,251.8,236.1,244.6,245.5,1.0457174332139907,0.06449306881888202,0.09255510468100067,1.0335996236571152,0.2435693486178811,0.6133773653153217,2967]
["High","O95628-1","CCR4-NOT transcription complex subunit 4 [OS=Homo sapiens]",19,8,15,8,575,63.5,7.03,22.75,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CNOT4","ENSG00000080802","","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",373.4,328,334.1,279.2,289.4,273.7,1.229371957734774,0.2979214823430446,0.012572099979309337,1.9005921739247646,0.07347526694494558,1.1338588274056562,1336]
["High","O95630","STAM-binding protein [OS=Homo sapiens]",17,8,15,8,424,48,6.29,30.37,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","STAMBP","ENSG00000124356","EGF/EGFR signaling pathway","Metalloprotease DUBs","Endocytosis",840.6,859.9,906,836.1,903.9,829,1.0145971195017516,0.02090696969519547,0.7052787983427011,0.1516391714526756,0.833356061964257,0.07916940110636601,6608]
["High","O95639","Cleavage and polyadenylation specificity factor subunit 4 [OS=Homo sapiens]",13,3,11,3,269,30.2,8.31,18.7,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CPSF4","ENSG00000160917","mRNA processing","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA surveillance pathway; Influenza A",496.9,534.5,534.3,541.9,515.5,518.7,0.9934014339191675,-0.009551265661457392,0.8287341542154728,0.08158476242134503,0.9088140837239342,0.04152495139956599,7120]
["High","O95671-1","N-acetylserotonin O-methyltransferase-like protein [OS=Homo sapiens]",40,20,61,20,621,68.8,6.07,143.5,"other metabolic processes","cytosol","other molecular function","ASMTL","ENSG00000169093","","","Pyrimidine metabolism; Metabolic pathways",2451.2,2666.6,2442.3,2394.9,2546.6,2453.5,1.0223258958755916,0.03185517026353062,0.5552938340054765,0.2554771489158081,0.7286948329268504,0.13745430998572228,5950]
["High","O95674-1","phosphatidate cytidylyltransferase 2 [OS=Homo sapiens]",28,8,30,8,445,51.4,7.09,76.88,"cell organization and biogenesis;other metabolic processes","other membranes;mitochondrion;ER/Golgi","other molecular function","CDS2","ENSG00000101290","","Synthesis of PG","Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system",829.4,895.9,857.8,844.7,902.7,884.3,0.9815328494889236,-0.026891542935382498,0.5636578228295481,0.24898446118423426,0.734608626381758,0.13394397611596384,5991]
["High","O95684","FGFR1 oncogene partner [OS=Homo sapiens]",29,6,8,6,399,43,4.81,15.09,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","CEP43","ENSG00000213066","Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",141.8,164,121.9,113.4,148.7,145.5,1.0493130520117764,0.06944515571052,0.7068075679468362,0.15069880905215183,0.8345309981141534,0.07855752709749811,6613]
["High","O95696-2","Isoform 2 of Bromodomain-containing protein 1 [OS=Homo sapiens]",10,9,13,9,1189,133.2,8.59,26.54,"","","","BRD1","","","","",498.4,497,521.7,537.7,530.2,550.8,0.9372335825044787,-0.0935194458029854,0.027786714706543675,1.5561627979208066,0.11784827182438512,0.9286767817661858,1841]
["High","O95707","Ribonuclease P protein subunit p29 [OS=Homo sapiens]",6,1,2,1,220,25.4,10.07,3.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP4","ENSG00000105171","","tRNA processing in the nucleus","Ribosome biogenesis in eukaryotes",50,45.1,50,42.4,42.4,38.1,1.1806346623270951,0.2395626036940827,0.02714390930652191,1.5663276044292105,0.11638640519787098,0.9340977455654951,1821]
["High","O95714","E3 ubiquitin-protein ligase HERC2 [OS=Homo sapiens]",3,14,19,14,4834,526.9,6.28,37.23,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HERC2","ENSG00000128731","Prader-Willi and Angelman syndrome","SUMOylation of DNA damage response and repair proteins; Antigen processing: Ubiquitination & Proteasome degradation; Nonhomologous End-Joining (NHEJ); Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint","Ubiquitin mediated proteolysis",389.5,374.7,375.9,380.7,406.5,386.1,0.9717037415835674,-0.04141157086827666,0.2943690321301415,0.5311078800763979,0.49567250439338895,0.3048051713135669,4637]
["High","O95716","ras-related protein Rab-3D [OS=Homo sapiens]",41,8,19,5,219,24.3,4.93,39.34,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3D","ENSG00000105514","","Neutrophil degranulation; RAB geranylgeranylation","Pancreatic secretion",579.9,631,560.3,551.1,666.8,576.6,0.9870158818612427,-0.018854795921887595,0.8587688183178315,0.06612373307411355,0.924481860392338,0.03410160587722449,7253]
["High","O95747","Serine/threonine-protein kinase OSR1 [OS=Homo sapiens]",37,16,61,14,527,58,6.43,137.72,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol","kinase activity;other molecular function","OXSR1","ENSG00000172939","","","",2143.2,2238.1,2173.7,2098.1,2092.5,2054.3,1.049656519720091,0.06991731040069506,0.0294939351603623,1.5302672788413942,0.12197491829031187,0.9137294641448092,1888]
["High","O95749","geranylgeranyl pyrophosphate synthase [OS=Homo sapiens]",17,5,9,5,300,34.8,6.14,16.5,"other metabolic processes","cytosol","other molecular function","GGPS1","ENSG00000152904","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Terpenoid backbone biosynthesis; Metabolic pathways",515.6,505.1,485.2,506.3,467.2,486.3,1.0315796684477327,0.044855244235611706,0.3455544038501181,0.4614835678791588,0.5479465445291881,0.26126180747980204,4924]
["High","O95754-1","Semaphorin-4F [OS=Homo sapiens]",2,1,2,1,770,83.5,6.95,5.43,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","SEMA4F","ENSG00000135622","","RND3 GTPase cycle","Axon guidance",31.4,32.8,26.7,22.2,23.3,22.8,{"$f":"AVERAGE(T898:V898)/AVERAGE(W898:Y898)","v":1.3308931185944362},{"$f":"LOG(Z898,2)","v":0.41239471590401644},{"$f":"TTEST(T898:V898,W898:Y898,2,2)","v":0.015809543357719856},{"$f":"-LOG10(AB898)","v":1.8010806740327838},{"$f":"AB898*7808/AF898","v":0.08385931694094881},{"$f":"-LOG10(AD898)","v":1.0764486793756285},1472]
["High","O95757","Heat shock 70 kDa protein 4L [OS=Homo sapiens]",31,19,58,14,839,94.5,5.88,120.14,"stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","HSPA4L","ENSG00000164070","","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",913,969.5,951.4,944.1,954.7,936.1,0.9996472538713888,-5.0899486870371316E-4,0.9857208550038711,0.006246054932513043,0.993226020889176,2.9519111668573116E-3,7749]
["High","O95758-1","Isoform 1 of Polypyrimidine tract-binding protein 3 [OS=Homo sapiens]",9,6,44,2,521,56.5,9.22,71.01,"","","","PTBP3","","","","",141.9,158,139.3,168.6,175.9,151.6,0.8853053819794396,-0.17575290288747955,0.11032281389342624,0.9573346695769253,0.27113645920046336,0.5668120797454373,3177]
["High","O95772-1","STARD3 N-terminal-like protein [OS=Homo sapiens]",12,3,5,3,234,26.6,4.81,9.62,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STARD3NL","ENSCANG00000042172; ENSCATG00000036966; ENSCSAG00000015104; ENSG00000010270; ENSGGOG00000013471; ENSMFAG00000043802; ENSMLEG00000030425; ENSMMUG00000023659; ENSMNEG00000034363; ENSPANG00000016262; ENSPPAG00000039214; ENSPTRG00000019094; ENSRBIG00000036179; ENSRROG00000026971","","Pregnenolone biosynthesis","",347.3,392.9,376.1,382.6,378.2,401.1,0.9607539375161376,-0.05776111090257398,0.36964406400724675,0.4322162636030704,0.571860679962073,0.2427097636781209,5047]
["High","O95777","U6 snRNA-associated Sm-like protein LSm8 [OS=Homo sapiens]",52,3,17,3,96,10.4,4.48,40.09,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","LSM8","ENSG00000128534","","mRNA Splicing - Major Pathway","RNA degradation; Spliceosome",298.3,277.8,247.3,297.2,326,295.6,0.8961689159773617,-0.15815740805665465,0.14867506742170997,0.8277618558832001,0.327925120460088,0.4842253132503525,3540]
["High","O95782-2","Isoform B of AP-2 complex subunit alpha-1 [OS=Homo sapiens]",40,31,81,22,955,105.3,7.66,182.32,"","","","AP2A1","","","","",3216.4,3290.8,3255.3,2880.4,3086.6,2867.6,1.105030222081362,0.14408582721911725,0.014012944808618822,1.853470588501332,0.07832002366907356,1.1061271899568788,1397]
["High","O95785-3","Isoform 3 of Protein Wiz [OS=Homo sapiens]",19,12,21,3,965,102.9,9.52,51.56,"","","","WIZ","","","","",480.4,452.3,466.8,482.2,513.4,505.1,0.9325648030918905,-0.10072411445147286,0.05253024696569669,1.2795905574000674,0.17394239538089895,0.7595945535005024,2358]
["High","O95785-4","Isoform 4 of Protein Wiz [OS=Homo sapiens]",19,10,20,1,835,89.3,9.48,51.01,"","","","WIZ","","","","",15.9,10,13.2,19.5,11.7,18.6,0.785140562248996,-0.34897713476072867,0.2997213720428651,0.5232822879874512,0.5012260597367082,0.2999663572596217,4669]
["High","O95786","Probable ATP-dependent RNA helicase DDX58 [OS=Homo sapiens]",1,1,1,1,925,106.5,6.4,3.27,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","DDX58","ENSG00000107201","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Pathways of nucleic acid metabolism and innate immune sensing; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation","ISG15 antiviral mechanism; Ub-specific processing proteases; OAS antiviral response; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation","NF-kappa B signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease",43.6,35.1,39.3,44.6,47.3,56.9,0.7930107526881721,-0.3345876668588277,0.08307533791979711,1.0805278834960796,0.22831828175916083,0.6414593125603801,2841]
["High","O95789","Zinc finger MYM-type protein 6 [OS=Homo sapiens]",3,3,4,3,1325,148,8.22,0,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZMYM6","ENSG00000163867","","","",24.6,32.8,26.5,23.5,27.7,28.9,1.0474406991260925,0.06686856803111328,0.6917072389044978,0.16007767928759353,0.8245572704376058,0.08377917462074123,6550]
["High","O95793","double-stranded RNA-binding protein Staufen homolog 1 [OS=Homo sapiens]",36,18,38,18,577,63.1,9.44,75.33,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","STAU1","ENSG00000124214","","","",2256.4,2157.3,2107.7,2063.9,1908.4,1873.9,1.1154938250487496,0.157682527390925,0.036786373913908044,1.4343130190944702,0.13983836782852677,0.8543736536970941,2054]
["High","O95801","Tetratricopeptide repeat protein 4 [OS=Homo sapiens]",51,15,50,15,387,44.7,5.6,111.91,"stress response","nucleus;other cell component","other molecular function","TTC4","ENSG00000243725","","","",2367.8,2304.2,2336.5,2433.2,2322.8,2305.4,0.9925085677061206,-0.010848538693448281,0.7092528852888353,0.14919888878911242,0.8366590917563418,0.07745146521868075,6619]
["Medium","O95807","transmembrane protein 50A [OS=Homo sapiens]",6,1,1,1,157,17.4,5.87,2.4,"transport","other membranes;ER/Golgi;other cell component","","TMEM50A","ENSG00000183726","","","",61.1,61,54.8,54.7,59.5,62.8,0.9994350282485874,-8.1531227990159182E-4,0.992043046789829,3.469482505424548E-3,0.9974082036228412,1.1270640568179545E-3,7766]
["High","O95816","BAG family molecular chaperone regulator 2 [OS=Homo sapiens]",37,8,19,8,211,23.8,6.7,30.16,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","BAG2","ENSG00000112208","Malignant pleural mesothelioma","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",768,845.8,718.1,868.7,766.6,726.4,0.9873819706143878,-0.01831979287366395,0.8686215018560177,0.061169424315442825,0.9299597815016847,0.031535833219805604,7293]
["High","O95817","BAG family molecular chaperone regulator 3 [OS=Homo sapiens]",2,1,1,1,575,61.6,6.95,2.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BAG3","ENSG00000151929","","Regulation of HSF1-mediated heat shock response","",20.7,20.8,15.8,34.1,14.5,13.4,0.9241935483870967,-0.11373307651733286,0.8320795539001877,0.07983514946867018,0.9109474420713216,0.04050667931335178,7132]
["High","O95819","Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",18,19,46,1,1239,142,7.46,103.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","cytoskeletal activity;kinase activity;other molecular function","MAP4K4","ENSG00000071054","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma","Oxidative Stress Induced Senescence","MAPK signaling pathway",34.2,36.4,32,47.6,34.1,38.5,0.8535773710482527,-0.22840616510413175,0.23248928336950808,0.6335970611858682,0.4278284997758942,0.3687302882938487,4243]
["High","O95819-3","Isoform 3 of Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",17,19,47,1,1320,150.9,7.42,106.24,"","","","MAP4K4","","","","",2299.3,2199.3,2296.5,2326.2,2372.1,2328.5,0.9670262423862925,-0.04837305394754502,0.09920723403976735,1.0034566586018099,0.2547221582974362,0.5939332740873066,3041]
["High","O95822","Malonyl-CoA decarboxylase, mitochondrial [OS=Homo sapiens]",14,5,7,5,493,55,8.95,19.9,"other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","MLYCD","ENSG00000103150","","","beta-Alanine metabolism; Propanoate metabolism; Metabolic pathways; Peroxisome; AMPK signaling pathway; Alcoholic liver disease",305.5,328.2,278.5,268.5,294.8,300.6,1.0559092487556432,0.07848584606347811,0.4079859596694376,0.3893547823586677,0.6053885163624038,0.21796582144971655,5262]
["High","O95825-1","Quinone oxidoreductase-like protein 1 [OS=Homo sapiens]",22,6,16,6,349,38.7,5.78,20.08,"other metabolic processes","","other molecular function","CRYZL1","ENSG00000205758","","","",408.2,426.4,354.8,356.1,408.9,398.9,1.0219090987198212,0.03126687077779756,0.767849726225232,0.11472376624058274,0.8714201544137516,0.059772399817458625,6880]
["High","O95831-1","Apoptosis-inducing factor 1, mitochondrial [OS=Homo sapiens]",29,16,46,16,613,66.9,8.95,115.94,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","AIFM1","ENSG00000156709","Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70","","Apoptosis; Necroptosis",1869.8,1821.1,1869.5,2075.2,2134.8,2172.2,0.8712356240794709,-0.19886514906023742,1.0916995887619045E-3,2.961896853290758,0.02202581495879315,1.657068013651034,387]
["High","O95834","echinoderm microtubule-associated protein-like 2 [OS=Homo sapiens]",6,4,5,4,649,70.6,6.32,10.72,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","EML2","ENSG00000125746","","","",288.8,311.2,312.9,322.4,367.8,324.1,0.9000295770482105,-0.15195568237878154,0.11400330532132275,0.9430825568915839,0.27669810629433883,0.5579938131349182,3217]
["Medium","O95857","Tetraspanin-13 [OS=Homo sapiens]",4,1,1,1,204,22.1,7.93,1.89,"other biological processes","plasma membrane;other membranes","other molecular function","TSPAN13","ENSG00000106537","","","",91.4,81.1,85.4,98.2,93.9,89.4,0.9161634103019537,-0.12632314917837803,0.11529701209934952,0.9381819472202944,0.2787117865237526,0.554844664892762,3230]
["High","O95861-1","3'(2'),5'-bisphosphate nucleotidase 1 [OS=Homo sapiens]",47,11,21,11,308,33.4,5.69,35.66,"other metabolic processes;developmental processes","cytosol","other molecular function","BPNT1; HEL20","ENSG00000162813; ENSPTRG00000001996","","Cytosolic sulfonation of small molecules","Sulfur metabolism; Metabolic pathways",834.6,833.4,760.5,845.5,916.7,844.7,0.9315662280869998,-0.10226975617001474,0.1571144856176819,0.8037837720968322,0.33981991792323,0.46875116934385463,3610]
["High","O95863","Zinc finger protein SNAI1 [OS=Homo sapiens]",4,1,1,1,264,29.1,8.65,2.92,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SNAI1","ENSG00000124216","Neural crest differentiation; Mesodermal commitment pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Epithelial to mesenchymal transition in colorectal cancer; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; CCL18 signaling pathway","Regulation of PTEN gene transcription","Adherens junction",19.2,18.3,17.2,22.3,15,18.6,0.9785330948121647,-0.03130745005063342,0.863669222501974,0.063652556534847,0.9272005072590971,0.03282633944764582,7273]
["High","O95864","fatty acid desaturase 2 [OS=Homo sapiens]",16,7,10,7,444,52.2,8.82,19.47,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","FADS2","ENSG00000134824","PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis","alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","alpha-Linolenic acid metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway",434.9,399.8,397.4,530.9,549.1,546.5,0.7575161389486628,-0.4006514692282823,6.0265531846836963E-4,3.219931006411571,0.01768997265639485,1.7522728383840027,266]
["High","O95865","N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [OS=Homo sapiens]",48,10,40,9,285,29.6,6.01,100.42,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion","other molecular function","DDAH2","ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076","Nitric oxide metabolism in cystic fibrosis","eNOS activation","",1302.5,1323.5,1308.7,1307.1,1364.5,1344.3,0.9797803730172564,-0.0294697030770502,0.20560953399646162,0.6869567512231892,0.3985598911232305,0.3995064084461342,4028]
["High","O95873","Uncharacterized protein C6orf47 [OS=Homo sapiens]",4,1,1,1,294,31.7,6.37,2.78,"","","","C6orf47","ENSG00000203623; ENSG00000204439; ENSG00000226103; ENSG00000226531; ENSG00000228177; ENSG00000228435; ENSG00000235360","","","",42,50.4,35.6,46.3,48.5,51.7,0.8737201365187712,-0.19475685442224808,0.24793782334410092,0.6056572158032828,0.44636811728631315,0.35030683329340934,4337]
["High","O95881","Thioredoxin domain-containing protein 12 [OS=Homo sapiens]",31,5,18,5,172,19.2,5.4,40.09,"other biological processes","ER/Golgi","other molecular function","TXNDC12","ENSG00000117862","","","Glutathione metabolism; Metabolic pathways",1071.9,1085.7,1081.5,1008.3,921.9,909.8,1.1405281690140845,0.18970207908763312,0.013129284270113424,1.8817589483973918,0.07537753792723942,1.122758052108974,1360]
["High","O95900","Mitochondrial mRNA pseudouridine synthase TRUB2 [OS=Homo sapiens]",8,3,6,2,331,36.7,8.98,11.66,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","TRUB2","ENSG00000167112","","","",219,217.8,206.9,188,196.3,164.8,1.1722819158623203,0.2293195575654466,0.036325534614539565,1.4397879853317734,0.13889802853590838,0.8573039184240294,2042]
["High","O95905","Protein ecdysoneless homolog [OS=Homo sapiens]",21,9,9,9,644,72.7,4.87,11.41,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ECD","ENSG00000122882","","","",227.8,206.9,224.5,300.7,276.7,301.8,0.7497725204731575,-0.41547514376601263,2.1696610341797183E-3,2.6636081106141796,0.029772782697496027,1.5261805723506152,569]
["High","O95983-1","methyl-CpG-binding domain protein 3 [OS=Homo sapiens]",29,8,27,8,291,32.8,5.34,30.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MBD3","ENSG00000071655; ENSPTRG00000010209","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; Regulation of TP53 Activity through Acetylation","",920.5,876,874.7,939.1,798.9,792.5,1.0556016597510374,0.07806552416703143,0.40262169331967185,0.39510282896248394,0.6011991167412503,0.22098166613350417,5229]
["High","O95985","DNA topoisomerase 3-beta-1 [OS=Homo sapiens]",13,7,11,7,862,96.6,8.12,19.99,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP3B","ENSG00000100038","","","Homologous recombination; Fanconi anemia pathway",302.8,268.6,300.7,284.9,276,287.3,1.0281773166705968,0.0400890892609591,0.5295650521655163,0.27608068322181695,0.7087493876085621,0.14950730334889542,5834]
["High","O95989","Diphosphoinositol polyphosphate phosphohydrolase 1 [OS=Homo sapiens]",25,3,10,3,172,19.5,6.34,26.94,"cell-cell signaling;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT3","ENSG00000272325","","Synthesis of pyrophosphates in the cytosol","",485.5,554.2,498.7,477.8,547.6,502.2,1.007069913589945,0.010163842717383114,0.9082855983871898,0.041777571852088136,0.951421243923689,0.02162715561127361,7454]
["High","O95995","Growth arrest-specific protein 8 [OS=Homo sapiens]",4,2,2,2,478,56.3,7.94,2.7,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","GAS8","ENSG00000141013","Ciliopathies","Activation of SMO","",52.6,46.5,44.6,34.2,35.9,35.3,1.3633776091081593,0.4471851948201217,6.6001588373385675E-3,2.180445612738495,0.05153404020193953,1.2879058080798593,1000]
["High","O95997","Securin [OS=Homo sapiens]",7,1,1,1,202,22,6.6,2.33,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PTTG1","ENSG00000164611","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition","APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids","Cell cycle; Oocyte meiosis; Human T-cell leukemia virus 1 infection",24.5,28.5,29,27.3,22,20.5,1.174785100286533,0.23239687329579392,0.18001871353861765,0.7446823462071385,0.36824367705253513,0.43386470149760187,3817]
["Medium","O95999","B-cell lymphoma/leukemia 10 [OS=Homo sapiens]",3,1,1,1,233,26.2,5.74,2.26,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BCL10","ENSG00000142867","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling","NF-kappa B signaling pathway; C-type lectin receptor signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway; Shigellosis; Tuberculosis",105.9,98.2,74.3,97.6,61.8,53.3,1.3088857545839214,0.3883391778880565,0.25693409643789955,0.5901782588623107,0.4551137533999818,0.3418800400474039,4408]
["High","O96000","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [OS=Homo sapiens]",19,3,3,3,172,20.8,8.48,6.91,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB10","ENSG00000140990","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Modulators of TCR signaling and T cell activation; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",54.8,74.3,53.4,69.6,47.9,55.8,1.0530871321407962,0.0746248094945721,0.7570839993326008,0.12085593235886558,0.8656189583817466,0.06267324041863521,6829]
["High","O96005-1","Cleft lip and palate transmembrane protein 1 [OS=Homo sapiens]",26,10,31,10,669,76,6.3,69.79,"developmental processes;other biological processes","plasma membrane;other membranes;other cell component","","CLPTM1","ENSG00000104853","","","",1099.7,1105,1006.3,903.8,979.8,1029.2,1.1023757209557812,0.14061601916861693,0.11003907490319763,0.9584530693740053,0.27078004943087525,0.5673833368157821,3173]
["High","O96006","zinc finger BED domain-containing protein 1 [OS=Homo sapiens]",10,7,11,7,694,78.1,6.1,24.05,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED1","ENSG00000214717","","SUMOylation of chromatin organization proteins","",453.3,491.4,482.6,613.2,618.8,574,0.7903100775193799,-0.33950929029401994,0.002269165338873984,2.6441338588332,0.03018337813616366,1.520232155422179,587]
["High","O96007","molybdopterin synthase catalytic subunit [OS=Homo sapiens]",23,3,4,3,188,20.9,5.44,8.19,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","MOCS2","ENSG00000164172","","Molybdenum cofactor biosynthesis","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system",274.5,281.2,305.4,253.5,239,276,1.1204944697462589,0.16413552837589557,0.09673285515656233,1.0144259934481967,0.25109379423618305,0.6001640207091659,3008]
["High","O96008","Mitochondrial import receptor subunit TOM40 homolog [OS=Homo sapiens]",45,12,98,12,361,37.9,7.25,220.56,"cell organization and biogenesis;transport","other membranes;cytosol;mitochondrion;other cell component","transporter activity","TOMM40","ENSG00000130204","IL-18 signaling pathway","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",2867.8,3146.6,2683.2,2268.4,2941.6,2735.4,1.0946711304654262,0.13049750936094742,0.3558602900607776,0.44872047159059825,0.5579432017659741,0.2534100096916804,4980]
["High","O96011-1","Peroxisomal membrane protein 11B [OS=Homo sapiens]",7,2,3,2,259,28.4,9.85,7.3,"cell organization and biogenesis;signal transduction","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PEX11B","ENSG00000131779; ENSPPAG00000024465; ENSPTRG00000001203","","Class I peroxisomal membrane protein import","Peroxisome",216.9,238.3,218.7,224.3,225.4,229.3,0.9924889543446245,-0.01087704865283335,0.8205350448547035,0.08590286560175271,0.9033753003702094,0.0441317878719975,7092]
["High","O96013-1","serine/threonine-protein kinase PAK 4 [OS=Homo sapiens]",12,6,13,6,591,64,9.73,26.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","PAK4","ENSG00000130669","Integrin-mediated cell adhesion; Focal adhesion; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle","ErbB signaling pathway; Ras signaling pathway; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Regulation of actin cytoskeleton; Human immunodeficiency virus 1 infection; MicroRNAs in cancer; Renal cell carcinoma",422.7,346.1,411.4,456.8,399.4,449.1,0.9041599632268441,-0.1453500592619997,0.23548123963728287,0.6280436866095949,0.4313013181064754,0.3652192145980917,4263]
["High","O96017-1","Serine/threonine-protein kinase Chk2 [OS=Homo sapiens]",26,11,24,11,543,60.9,5.91,43.01,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","CHEK2","ENSG00000183765","miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection",685.8,710,731.2,900.1,968.6,920.3,0.7626389386877017,-0.39092790106763975,8.0068739991266116E-4,3.0965370057521766,0.01917720005680386,1.7172148011614803,326]
["High","O96018","amyloid-beta A4 precursor protein-binding family A member 3 [OS=Homo sapiens]",3,2,2,2,575,61.4,4.94,2.99,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","APBA3","ENSG00000011132","","Neurexins and neuroligins","",112.9,107.2,113.2,90.7,101.6,124.8,1.0510879848628194,0.07188344000640913,0.6259383057822732,0.20346846995043222,0.7810973775847833,0.10729482026931811,6257]
["High","O96019-1","Actin-like protein 6A [OS=Homo sapiens]",47,18,54,18,429,47.4,5.6,115.33,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","ACTL6A","ENSCANG00000034249; ENSCATG00000017467; ENSCCAG00000029449; ENSCJAG00000013036; ENSCSAG00000013017; ENSG00000136518; ENSGGOG00000015710; ENSMFAG00000030153; ENSMMUG00000009742; ENSPANG00000024431; ENSPPAG00000031814; ENSPTRG00000023973; ENSRBIG00000036584; ENSRROG00000035215","Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; UCH proteinases; HATs acetylate histones; DNA Damage Recognition in GG-NER","Thermogenesis; Hepatocellular carcinoma",3069.2,3079.9,3170.5,3284.3,3099.5,3214.4,0.9709737242399616,-0.04249583984188134,0.21284987564447128,0.6719265992192183,0.4069372744936415,0.39047252797545545,4084]
["High","O96028-1","Histone-lysine N-methyltransferase NSD2 [OS=Homo sapiens]",17,19,38,19,1365,152.2,8.69,80.41,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD2","ENSG00000109685","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Lysine degradation; Metabolic pathways; Transcriptional misregulation in cancer",1440.4,1493.6,1507,1828.4,1795.9,1872.4,0.8079393090399692,-0.30768117051871036,3.0541861675882528E-4,3.515104494099477,0.013784442541346288,1.860610792569637,173]
["High","P00167-1","Cytochrome b5 [OS=Homo sapiens]",39,4,9,4,134,15.3,4.96,29.2,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","CYB5A","ENSG00000166347; ENSPTRG00000010111","Oxidation by cytochrome P450","Vitamin C (ascorbate) metabolism","",332.1,361.8,343,387.6,324.3,333.1,0.9922488038277514,-0.011226176853799903,0.9066137897814672,0.042577679519056125,0.9509457913237098,0.021844239319150135,7444]
["High","P00338-1","L-lactate dehydrogenase A chain [OS=Homo sapiens]",72,24,204,21,332,36.7,8.27,395.17,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HEL-S-133P; LDHA","ENSG00000134333; ENSG00000288299","Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glycolysis and gluconeogenesis","Pyruvate metabolism","Glycolysis / Gluconeogenesis; Cysteine and methionine metabolism; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer",6811.3,7013.3,6646.8,6096.8,6986.4,6686,1.035519899641867,0.05035527817337704,0.45312348721982637,0.3437834260009111,0.6455004904602087,0.19010342341447595,5481]
["High","P00367","Glutamate dehydrogenase 1, mitochondrial [OS=Homo sapiens]",48,24,107,10,558,61.4,7.8,248.82,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","GLUD1","ENSG00000148672","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension","Transcriptional activation of mitochondrial biogenesis; Glutamate and glutamine metabolism","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Nitrogen metabolism; Metabolic pathways; Carbon metabolism; Necroptosis; Proximal tubule bicarbonate reclamation",4280.2,4228.7,4259.2,4488.7,4522.5,4612.7,0.9371839194356975,-0.09359589479365976,0.002027862428597021,2.6929615111373972,0.029052385032083558,1.5368182087554043,545]
["High","P00374","dihydrofolate reductase [OS=Homo sapiens]",38,6,19,6,187,21.4,7.42,30.46,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;mitochondrion","nucleic acid binding activity;other molecular function","DHFR","ENSG00000228716","Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Ethanol effects on histone modifications; Nucleotide metabolism","G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","One carbon pool by folate; Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance",548.7,551,565.9,640.1,602.8,606.7,0.9005190311418683,-0.1511713292012621,0.009202364054410012,2.0361005896221998,0.062048409790011555,1.2072693443549816,1158]
["High","P00387","NADH-cytochrome b5 reductase 3 [OS=Homo sapiens]",46,13,43,13,301,34.2,7.59,99.19,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CYB5R3","ENSG00000100243","Oxidation by cytochrome P450","Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism","Amino sugar and nucleotide sugar metabolism",1625.7,1838.3,1615.8,1539.7,1684.5,1618.8,1.0488953128226306,0.06887069392242579,0.3994605809984434,0.39852607066665874,0.5984244467451738,0.22299067304857045,5212]
["High","P00390","Glutathione reductase, mitochondrial [OS=Homo sapiens]",48,18,57,17,522,56.2,8.5,129.23,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","other molecular function","GSR","ENSG00000104687","Glutathione metabolism; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II","","Glutathione metabolism; Metabolic pathways; Thyroid hormone synthesis; Diabetic cardiomyopathy",1956,2017.7,2002.1,1934.1,2045.8,2084.6,0.9853738972710033,-0.021256839978142317,0.5770499782590603,0.23878657099998538,0.7425191546220737,0.12929233845604282,6068]
["High","P00403","Cytochrome c oxidase subunit 2 [OS=Homo sapiens]",28,5,19,5,227,25.5,4.82,32.11,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO2","ENSG00000198712","Electron transport chain: OXPHOS system in mitochondria; Endothelin pathways; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly; CCL18 signaling pathway","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",957,996.9,983.8,882.4,893.4,906.6,1.095175961825231,0.1311626861349258,3.3888095774234723E-3,2.4699528341716745,0.03546893455834112,1.4501518569857077,746]
["High","P00441","Superoxide dismutase [Cu-Zn] [OS=Homo sapiens]",92,14,102,14,154,15.9,6.13,283.23,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SOD1","ENSG00000142168","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species","Peroxisome; Longevity regulating pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis",3779,4108.7,3947,3800.6,3553.4,3814.9,1.0596119582053738,0.08353603038514235,0.15680274178257309,0.8046463477062256,0.3397102685455967,0.4688913253546156,3604]
["High","P00488","Coagulation factor XIII A chain [OS=Homo sapiens]",7,4,7,4,732,83.2,6.09,10.39,"protein metabolism;other metabolic processes;stress response","non-structural extracellular;other cell component","other molecular function","F13A1","ENSG00000124491","Complement system","Platelet degranulation ; Interleukin-4 and Interleukin-13 signaling; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades; Coronavirus disease",253.8,286.5,229.5,233.4,236,253.1,1.0654671280276815,0.09148608353543496,0.4217552396806127,0.3749395132433026,0.618067738631048,0.20896392474691183,5328]
["High","P00491","purine nucleoside phosphorylase [OS=Homo sapiens]",83,19,70,19,289,32.1,6.95,202.75,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PNP","ENSG00000198805","VEGFA-VEGFR2 signaling pathway","Neutrophil degranulation; Purine catabolism; Purine salvage","Purine metabolism; Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways",3132.5,3405.4,2950.1,2672.4,3209.9,2899,1.0804778335781717,0.11166947505269242,0.3132920438222249,0.5040506340617327,0.5142283536186529,0.288843980822999,4757]
["High","P00492","Hypoxanthine-guanine phosphoribosyltransferase [OS=Homo sapiens]",42,6,24,6,218,24.6,6.68,36.92,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HPRT1","ENSG00000165704","Mesodermal commitment pathway; Nucleotide metabolism","Purine salvage","Purine metabolism; Drug metabolism; Metabolic pathways",301.5,238,281.1,318.7,290.7,303.5,0.8988936356665572,-0.15377768034321684,0.2058554369589621,0.6864376581292433,0.3986406874443393,0.3994183769080768,4032]
["High","P00505","Aspartate aminotransferase, mitochondrial [OS=Homo sapiens]",53,20,119,20,430,47.5,9.01,261.14,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","other molecular function","GOT2","ENSG00000125166","Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis","Glyoxylate metabolism and glycine degradation; Gluconeogenesis; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Cysteine and methionine metabolism; Arginine and proline metabolism; Tyrosine metabolism; Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Fat digestion and absorption",5431.9,5580.4,5337.8,5472.1,5644.8,5794.4,0.9668150881363345,-0.04868810687942679,0.1847028707689563,0.7335263544275034,0.37400415325830155,0.4271235749996612,3856]
["High","P00519-2","Isoform IB of Tyrosine-protein kinase ABL1 [OS=Homo sapiens]",12,9,13,9,1149,124.9,8.84,29.2,"","","","ABL1","","","","",475.9,446.3,463.9,516,521.1,498.5,0.9026439176868977,-0.14777112102597245,0.01053252389115799,1.9774675470801735,0.06757431926225274,1.170218320651603,1217]
["High","P00533-1","epidermal growth factor receptor [OS=Homo sapiens]",12,9,10,9,1210,134.2,6.68,20.89,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function","EGFR","ENSG00000146648","Androgen receptor signaling pathway; Glioblastoma signaling pathways; AGE/RAGE pathway; Gastric cancer network 2; Spinal cord injury; Aryl hydrocarbon receptor pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Bladder cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; ERK pathway in Huntington's disease; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Extracellular vesicles in the crosstalk of cardiac cells; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Regulatory circuits of the STAT3 signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway","Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF/MAP kinase cascade; Cargo recognition for clathrin-mediated endocytosis; HCMV Early Events; NOTCH3 Activation and Transmission of Signal to the Nucleus; Signaling by ERBB4; SHC1 events in ERBB2 signaling; GRB2 events in ERBB2 signaling; PI3K events in ERBB2 signaling; ERBB2 Regulates Cell Motility; ERBB2 Activates PTK6 Signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Signal transduction by L1; GRB2 events in EGFR signaling; GAB1 signalosome; SHC1 events in EGFR signaling; EGFR downregulation; EGFR interacts with phospholipase C-gamma; Inhibition of Signaling by Overexpressed EGFR; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PLCG1 events in ERBB2 signaling; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; PTK6 promotes HIF1A stabilization; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors; Signaling by ERBB2 ECD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Calcium signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; Endocytosis; PI3K-Akt signaling pathway; Focal adhesion; Adherens junction; Gap junction; JAK-STAT signaling pathway; Regulation of actin cytoskeleton; GnRH signaling pathway; Estrogen signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Epithelial cell signaling in Helicobacter pylori infection; Shigellosis; Hepatitis C; Human cytomegalovirus infection; Human papillomavirus infection; Coronavirus disease; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer",242.2,231,223.9,258.4,259.9,286.3,0.8663932388764605,-0.20690611034077722,0.027042705692922414,1.5679498582659162,0.11614380970865688,0.9350039324932293,1818]
["High","P00558","phosphoglycerate kinase 1 [OS=Homo sapiens]",78,30,422,25,417,44.6,8.1,981.27,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol","kinase activity;other molecular function","PGK1","ENSG00000102144","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glycolysis and gluconeogenesis","Gluconeogenesis; Glycolysis; Manipulation of host energy metabolism","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway",19390.2,19398.6,20236.7,19444.8,19104.5,19412.6,1.0183499850764035,0.02623347001751668,0.3041462030947878,0.5169176008195839,0.5048413167015525,0.29684510922903057,4704]
["High","P00568","Adenylate kinase isoenzyme 1 [OS=Homo sapiens]",48,9,23,9,194,21.6,8.63,54.93,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK1","ENSG00000106992","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors",1250.1,1327,1268.9,1275.1,1262,1287.3,1.0056479447756512,0.008125337728250442,0.7814965660318259,0.10707292597071315,0.8796201798438081,0.0557048158116099,6937]
["High","P00734","Prothrombin [OS=Homo sapiens]",5,2,5,2,622,70,5.9,5.85,"protein metabolism;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","F2","ENSG00000180210","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; IL1 and megakaryocytes in obesity; Regulation of actin cytoskeleton; Complement and coagulation cascades","Cell surface interactions at the vascular wall; Regulation of Complement cascade; G alpha (q) signalling events; Peptide ligand-binding receptors; Thrombin signalling through proteinase activated receptors (PARs); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Defective F8 cleavage by thrombin; Gamma-carboxylation of protein precursors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Platelet Aggregation (Plug Formation); Defective factor XII causes hereditary angioedema","Phospholipase D signaling pathway; Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Platelet activation; Regulation of actin cytoskeleton; Pathogenic Escherichia coli infection; Coronavirus disease; Pathways in cancer",53.5,90.7,84.9,64.7,62.4,62.2,1.2102482831484416,0.2753030476009698,0.3159340883208006,0.500403512521824,0.5167183413508193,0.2867461225339243,4774]
["High","P00747","Plasminogen [OS=Homo sapiens]",5,4,13,4,810,90.5,7.24,18.2,"cell organization and biogenesis;protein metabolism;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLG","ENSG00000122194","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; Complement system; Fibrin complement receptor 3 signaling pathway; Complement and coagulation cascades","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by PDGF; Platelet degranulation ; Activation of Matrix Metalloproteinases; Dissolution of Fibrin Clot","Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Staphylococcus aureus infection; Influenza A",654.1,704.9,620,611,672.5,643.3,{"$f":"AVERAGE(T962:V962)/AVERAGE(W962:Y962)","v":1.027091550757733},{"$f":"LOG(Z962,2)","v":0.038564783347896994},{"$f":"TTEST(T962:V962,W962:Y962,2,2)","v":0.5976504565710185},{"$f":"-LOG10(AB962)","v":0.22355274438318415},{"$f":"AB962*7808/AF962","v":0.7580335875416686},{"$f":"-LOG10(AD962)","v":0.12031155088398987},6156]
["High","P00750-1","Tissue-type plasminogen activator [OS=Homo sapiens]",5,2,2,2,562,62.9,7.8,5.04,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;other molecular function","PLAT","ENSG00000104368","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; NOTCH1 regulation of endothelial cell calcification; Fibrin complement receptor 3 signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Complement and coagulation cascades","Signaling by PDGF; Dissolution of Fibrin Clot","Apelin signaling pathway; Complement and coagulation cascades; Transcriptional misregulation in cancer; Prostate cancer; Fluid shear stress and atherosclerosis",73.6,65.5,62.5,72.1,62.5,67.9,0.9955555555555556,-0.006426269159432832,0.9480350238164493,0.023175617968634515,0.9744941371720427,0.011220769374979046,7596]
["High","P00813","adenosine deaminase [OS=Homo sapiens]",25,6,9,6,363,40.7,5.95,14.19,"cell adhesion;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ADA","ENSG00000196839","","Purine salvage","Purine metabolism; Metabolic pathways; Primary immunodeficiency",419.9,438.8,425.9,430.3,445,414,0.9963546110292407,-0.005268793837045558,0.889105659722232,0.05104662518543696,0.9411790931549874,0.026327728572374517,7376]
["High","P00846","ATP synthase subunit A [OS=Homo sapiens]",4,1,5,1,226,24.8,10.1,12.85,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ATP6","ENSG00000198899","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",359.3,396.2,326.7,262,308.2,326.8,1.2064659977703456,0.27078725617582794,0.0907337742426298,1.0422310234481302,0.24105114300321653,0.6178908048621075,2939]
["High","P00918","Carbonic anhydrase 2 [OS=Homo sapiens]",13,3,4,3,260,29.2,7.4,8.46,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CA2","ENSG00000104267","Proximal tubule transport","Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Nitrogen metabolism; Metabolic pathways; Proximal tubule bicarbonate reclamation; Collecting duct acid secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion",186.5,187.8,209.7,173.1,164.2,169.9,1.1514195583596216,0.20341362362797255,0.03244317021782618,1.4888767148542836,0.12845652792129147,0.8912438208008406,1972]
["High","P00966","Argininosuccinate synthase [OS=Homo sapiens]",19,8,18,8,412,46.5,8.02,33.05,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASS1","ENSG00000130707","Alanine and aspartate metabolism; Amino acid metabolism","Urea cycle","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids; Fluid shear stress and atherosclerosis",878.3,951.8,892.5,883.6,910.6,900.2,1.0104661520190024,0.015020996005428717,0.7135193026948607,0.14659427350873114,0.8399153799851459,0.07576446614847208,6633]
["High","P01023","alpha-2-macroglobulin [OS=Homo sapiens]",5,8,58,8,1474,163.2,6.46,101.45,"other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","A2M","ENSG00000175899","Complement system; Complement and coagulation cascades","Degradation of the extracellular matrix; Platelet degranulation ; HDL assembly; Intrinsic Pathway of Fibrin Clot Formation","Complement and coagulation cascades",1683,2457.5,1888.5,1617.2,1657.5,2054,1.1314204214911705,0.17813511614925862,0.43656884616160374,0.35994725905941927,0.6325347097475973,0.1989156379968093,5389]
["High","P01024","Complement C3 [OS=Homo sapiens]",1,2,4,2,1663,187,6.4,5.7,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","C3","ENSG00000125730","Allograft rejection; Complement system; TYROBP causal network in microglia; Cells and molecules involved in local acute inflammatory response ; 16p11.2 distal deletion syndrome; Complement system in neuronal development and plasticity; Acquired partial lipodystrophy / Barraquer-Simons syndrome; Complement activation; Complement and coagulation cascades","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; G alpha (i) signalling events; Neutrophil degranulation; Peptide ligand-binding receptors; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Purinergic signaling in leishmaniasis infection; Alternative complement activation; Activation of C3 and C5","Neuroactive ligand-receptor interaction; Phagosome; Complement and coagulation cascades; Neutrophil extracellular trap formation; Alcoholic liver disease; Shigellosis; Pertussis; Legionellosis; Leishmaniasis; Chagas disease; Staphylococcus aureus infection; Tuberculosis; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Coronavirus disease; Viral carcinogenesis; Systemic lupus erythematosus",43.8,70.2,53.4,36.4,48,56.1,1.1914590747330962,0.25272939744205547,0.40326179048184435,0.39441292594434096,0.6014647679240193,0.2207898073005667,5235]
["High","P01033","Metalloproteinase inhibitor 1 [OS=Homo sapiens]",10,2,2,2,207,23.2,8.1,4.81,"stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","TIMP1","ENSG00000102265","Matrix metalloproteinases; Mammary gland development pathway - Puberty (Stage 2 of 4); IL1 and megakaryocytes in obesity; Lung fibrosis; IL-6 signaling pathway; IL-18 signaling pathway; Burn wound healing; CCL18 signaling pathway","Interleukin-4 and Interleukin-13 signaling; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-10 signaling; Activation of Matrix Metalloproteinases","HIF-1 signaling pathway",133.9,154.7,139.1,117.3,126.9,114.7,1.1916968514906663,0.25301728406025664,0.03433431610525952,1.4642715987625678,0.13337429858202307,0.8749278515244213,2010]
["High","P01034","Cystatin-C [OS=Homo sapiens]",12,1,1,1,146,15.8,8.75,0,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CST3","ENSG00000101439","","Neutrophil degranulation; Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Salivary secretion",32.3,31.8,34.4,33,36.3,23.5,1.0614224137931034,0.08599891921616647,0.6531279934525291,0.18500170172167718,0.7981880377018857,0.09789478519518169,6389]
["High","P01111","GTPase NRas [OS=Homo sapiens]",69,10,37,3,189,21.2,5.17,55.68,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","NRAS","ENSG00000213281","Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling","Neutrophil degranulation; FCERI mediated MAPK activation; Regulation of RAS by GAPs; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",1324.5,1373,1248.7,1239.3,1346.8,1281.1,1.020428216797683,0.029174697890000052,0.6111925384922781,0.21382195631621856,0.7693360213683229,0.11388393282254959,6203]
["High","P01112","GTPase HRas [OS=Homo sapiens]",55,8,36,1,189,21.3,5.31,57.96,"stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","HRAS","ENSG00000174775; ENSG00000276536","Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; Pathways affected in adenoid cystic carcinoma; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; IL-2 signaling pathway; Malignant pleural mesothelioma; Alzheimer's disease; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling","Regulation of RAS by GAPs; EPHB-mediated forward signaling; FCERI mediated MAPK activation; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Focal adhesion; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Salmonella infection; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",47.2,61.3,68.4,70.2,66.2,48.9,0.9546681057744199,-0.06692883333680738,0.7719783957354656,0.11239485347794338,0.8735662773771761,0.05870413955656331,6900]
["High","P01116-2","Isoform 2B of GTPase KRas [OS=Homo sapiens]",62,9,38,3,188,21.4,8.12,58.59,"","","","KRAS","","","","",441.9,412.3,461.9,524.9,520,465.6,0.8713008937437934,-0.19875707187491648,0.05313321273718008,1.2746339233741861,0.17490055862221843,0.7572088034077757,2372]
["High","P01130","Low-density lipoprotein receptor [OS=Homo sapiens]",10,8,10,8,860,95.3,5.05,17.03,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LDLR","ENSG00000130164","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M signaling pathway; PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Lipid particles composition; Wnt signaling pathway and pluripotency; Statin inhibition of cholesterol production; Bile acids synthesis and enterohepatic circulation ; Metabolic pathway of LDL, HDL and TG, including diseases; Orexin receptor pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; DNA damage response (only ATM dependent)","Cargo recognition for clathrin-mediated endocytosis; Retinoid metabolism and transport; LDL clearance; Chylomicron clearance","Endocytosis; Ovarian steroidogenesis; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Cushing syndrome; Bile secretion; Cholesterol metabolism; Toxoplasmosis; Hepatitis C; Lipid and atherosclerosis",393.4,385.6,391.3,666.7,667.6,713.6,0.5714634503637872,-0.8072668653279684,4.8344740787824261E-5,4.31565076400204,0.007259148770602535,2.139114302978204,52]
["Medium","P01350","Gastrin [OS=Homo sapiens]",16,1,1,1,101,11.4,5.19,0,"signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","GAST","ENSG00000184502","Gastrin signaling pathway","Gastrin-CREB signalling pathway via PKC and MAPK","Gastric acid secretion",21.6,22.7,19.1,19.7,17.9,19.8,1.104529616724739,0.1434321034637198,0.17957409752519873,0.7457563074969806,0.36791250419227284,0.43425545161051243,3811]
["Low","P01563","Interferon alpha-2 [OS=Homo sapiens]",10,1,1,1,188,21.5,6.76,0,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","IFNA2","ENSG00000188379","PI3K-Akt signaling pathway; Overview of interferons-mediated signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; SARS coronavirus and innate immunity; Overview of proinflammatory and profibrotic mediators; Type II interferon signaling (IFNG); Toll-like receptor signaling pathway","Factors involved in megakaryocyte development and platelet production; Regulation of IFNA signaling; TRAF6 mediated IRF7 activation","Cytokine-cytokine receptor interaction; PI3K-Akt signaling pathway; Necroptosis; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Alcoholic liver disease; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Autoimmune thyroid disease; Lipid and atherosclerosis",37.6,36.9,55.3,65.2,35.5,56.5,0.8256997455470739,-0.27631083425946773,0.4404441286978966,0.35610917496395117,0.6360251076147914,0.1965257398809404,5407]
["High","P01834","immunoglobulin kappa constant [OS=Homo sapiens]",19,1,1,1,107,11.8,6.52,2.75,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGKC","","","FCERI mediated NF-kB activation; Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers","",12.8,9.8,22.9,20.9,10,15.3,0.9848484848484848,-0.022026306329999072,0.9654309021893257,0.015278804092516586,0.9833139165528639,0.007307814352214531,7666]
["Medium","P01854","immunoglobulin heavy constant epsilon [OS=Homo sapiens]",4,1,1,1,428,47,8.06,0,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHE","ENSG00000211891; ENSG00000276192","","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; Interleukin-4 and Interleukin-13 signaling","",54.3,42.9,57.7,44.1,40.9,46.7,1.176157934700076,0.23408179853305408,0.18097410033242184,0.7423835736807873,0.3696169959182709,0.4322480670411801,3823]
["High","P02042","Hemoglobin subunit delta [OS=Homo sapiens]",13,2,12,2,147,16,8.05,25.21,"other metabolic processes;transport;other biological processes","cytosol;other cell component","other molecular function","HBD","ENSG00000223609","VEGFA-VEGFR2 signaling pathway","Factors involved in megakaryocyte development and platelet production","",473.6,476,472.2,306.1,312.5,383,1.4195287539936101,0.5054120726085122,0.004742855153277583,2.323960138492306,0.04276237071223022,1.3689382258510172,866]
["High","P02452","Collagen alpha-1(I) chain [OS=Homo sapiens]",9,11,16,11,1464,138.9,5.8,18.87,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi;other cell component","extracellular structural activity;other molecular function","COL1A1","ENSG00000108821","Focal adhesion; Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miR-509-3p alteration of YAP1/ECM axis; PI3K-Akt signaling pathway; Inflammatory response pathway; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Angiotensin II receptor type 1 pathway; Burn wound healing; CCL18 signaling pathway; NRP1-triggered signaling pathways in pancreatic cancer","GPVI-mediated activation cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Collagen degradation; Integrin cell surface interactions; ECM proteoglycans; Collagen chain trimerization; Syndecan interactions; MET activates PTK2 signaling; RUNX2 regulates osteoblast differentiation; Anchoring fibril formation; Crosslinking of collagen fibrils; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); Scavenging by Class A Receptors; GP1b-IX-V activation signalling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Platelet activation; Relaxin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Protein digestion and absorption; Amoebiasis; Human papillomavirus infection; Proteoglycans in cancer; Diabetic cardiomyopathy",227.1,505.3,351.4,282.2,258.2,439,1.1065958750255258,0.1461284510772631,0.7415154665892305,0.1298797859918989,0.8567257714011116,0.06715816877214097,6758]
["High","P02458-1","Isoform 1 of Collagen alpha-1(II) chain [OS=Homo sapiens]",3,4,4,4,1418,134.3,8.56,4.78,"","","","COL2A1","","","","",51.8,141.6,110.9,99.2,55.2,112.1,1.1418386491557222,0.19135880086805745,0.7094361670908136,0.149086674945576,0.8367488810642103,0.07740485972664056,6620]
["High","P02462","Collagen alpha-1(IV) chain [OS=Homo sapiens]",2,3,6,3,1669,160.5,8.28,20.23,"","","","","","","","",128.3,116.1,142.7,123.4,129.2,146.8,0.9692038057085629,-0.045128025151661345,0.7140651691038953,0.14626215056184172,0.8403045727751642,0.07556327310366062,6635]
["High","P02533","Keratin, type I cytoskeletal 14 [OS=Homo sapiens]",39,20,65,5,472,51.5,5.16,146.33,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KRT14","ENSG00000186847","Corticotropin-releasing hormone signaling pathway","Formation of the cornified envelope; Type I hemidesmosome assembly","Estrogen signaling pathway; Staphylococcus aureus infection",1361.6,1326.8,958.4,1423.9,1319.6,1787.3,0.8048909684823872,-0.31313472766414857,0.19899547942127985,0.701156789342518,0.39029306790287693,0.40860916226798055,3981]
["High","P02538","Keratin, type II cytoskeletal 6A [OS=Homo sapiens]",34,21,119,2,564,60,8,216.7,"cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6A","ENSG00000205420","Ectoderm differentiation; Ectoderm differentiation","Formation of the cornified envelope","",629.8,337.9,389.2,506,488.1,854.8,0.7338958299529449,-0.44635279513719867,0.3341835978314248,0.476014869661397,0.535791690321923,0.27100402621739594,4870]
["High","P02545","Prelamin-A/C [OS=Homo sapiens]",65,49,228,46,664,74.1,7.02,519.2,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LMNA","ENSG00000160789","Arrhythmogenic right ventricular cardiomyopathy; Adipogenesis; Fas ligand pathway and stress induction of heat shock proteins; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome","XBP1(S) activates chaperone genes; Signaling by BRAF and RAF1 fusions","Apoptosis; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy",10416.1,9844.2,10373,6639,6383.9,6641.5,1.5578049673521694,0.6395146234851926,5.5596433484711066E-5,4.2549530675472615,0.00789267186633862,2.10277595238287,55]
["High","P02647","Apolipoprotein A-I [OS=Homo sapiens]",8,2,10,1,267,30.8,5.76,21.78,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","APOA1","ENSG00000118137","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5","PPARA activates gene expression; Platelet degranulation ; Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging of heme from plasma; Scavenging by Class B Receptors; Heme signaling; Retinoid metabolism and transport; HDL clearance; Defective ABCA1 causes TGD; HDL assembly; Scavenging by Class A Receptors; ABC transporters in lipid homeostasis; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","PPAR signaling pathway; Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; African trypanosomiasis; Lipid and atherosclerosis",217.7,266.8,180.9,86.1,92.6,104.5,2.3495762711864407,1.232400600799869,0.007467923672454358,2.1268001295019214,0.055165135321214406,1.2583353121507124,1057]
["High","P02649","Apolipoprotein E [OS=Homo sapiens]",64,18,94,18,317,36.1,5.73,206.13,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","APOE","ENSG00000130203","Vitamin B12 metabolism; Alzheimer's disease and miRNA effects; Apoptosis-related network due to altered Notch3 in ovarian cancer; ApoE and miR-146 in inflammation and atherosclerosis; Statin inhibition of cholesterol production; Familial hyperlipidemia type 3; Alzheimer's disease","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Retinoid metabolism and transport; Nuclear signaling by ERBB4; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors","Cholesterol metabolism; Alzheimer disease",3608.5,3734.8,3768.8,3357.4,3328.3,3418.9,1.0997070641094153,0.1371192751688046,3.7882790738162394E-3,2.4215580350135224,0.03753665356390507,1.4255444478444423,788]
["High","P02671-1","Fibrinogen alpha chain [OS=Homo sapiens]",2,3,10,3,866,94.9,6.01,16.25,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGA","ENSG00000171560","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway","Regulation of TLR by endogenous ligand; Platelet degranulation ; Integrin cell surface interactions; Amyloid fiber formation; ER-Phagosome pathway; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease",89.4,315,173.1,154.5,125.1,251,1.0883905013192612,0.1221962709620864,0.84713812014831,0.07204577511448175,0.9190571685588446,0.03665747314333944,7197]
["High","P02675","Fibrinogen beta chain [OS=Homo sapiens]",11,7,61,7,491,55.9,8.27,96.62,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGB","ENSG00000171564","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway; Complement and coagulation cascades","Platelet degranulation ; Common Pathway of Fibrin Clot Formation; ER-Phagosome pathway; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease",452.2,1203.8,868.8,754.9,658,1084,1.0111738555809202,0.016031067489042244,0.9724109752260774,0.012150148087418175,0.9856659606082322,6.2702412899856026E-3,7703]
["High","P02679","Fibrinogen gamma chain [OS=Homo sapiens]",7,3,26,3,453,51.5,5.62,46.62,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGG","ENSG00000171557","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway","ER-Phagosome pathway; Platelet degranulation ; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Staphylococcus aureus infection; Coronavirus disease",306,520.2,375.5,347.7,368.9,457.6,1.0234202009879068,0.033398615671302624,0.9041867265742232,0.04374187268093546,0.9501870741711351,0.02219088178287538,7430]
["High","P02748","complement component C9 [OS=Homo sapiens]",4,2,4,2,559,63.1,5.59,2.69,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes","","C9","ENSG00000113600","Allograft rejection; Complement system; Complement system in neuronal development and plasticity; Complement activation; Complement and coagulation cascades","Regulation of Complement cascade; Terminal pathway of complement","Complement and coagulation cascades; Prion disease; Amoebiasis; Coronavirus disease; Systemic lupus erythematosus",110.4,127.8,106.3,90.6,102.4,93.5,1.2024432809773122,0.2659688439473863,0.061155857794490134,1.213561937875761,0.19054466786088547,0.7200031998752568,2506]
["Medium","P02749","Beta-2-glycoprotein 1 [OS=Homo sapiens]",3,1,1,1,345,38.3,7.97,1.61,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;other cell component","enzyme regulator activity;other molecular function","APOH","ENSG00000091583","","Platelet degranulation","Cholesterol metabolism",73.7,68.2,58.3,45.4,39.5,51,1.4731420161883737,0.5588965180686022,0.01862523318466326,1.7298982812546457,0.09180923024359262,1.037113653849485,1584]
["High","P02751","fibronectin [OS=Homo sapiens]",30,55,452,55,2386,262.5,5.71,976.91,"","","","","","","","",5080,11050.6,7686.7,6481.7,6159.6,9166.5,1.0921459294380909,0.1271656379525497,0.7513825423331879,0.1241388995793155,0.8631447536468341,0.06391636484294179,6797]
["Medium","P02753","Retinol-binding protein 4 [OS=Homo sapiens]",4,1,1,1,201,23,6.07,1.6,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other cell component","transporter activity;other molecular function","RBP4","ENSG00000138207","Sterol regulatory element-binding proteins (SREBP) signaling; Vitamin A and carotenoid metabolism","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events; Retinoid metabolism disease events","",60.3,45.1,47.9,48.5,41.8,34.8,1.2254196642685853,0.2932759074929579,0.19936466869721958,0.7003518046472335,0.39062467583134014,0.40824032572072916,3985]
["Medium","P02760","Protein AMBP [OS=Homo sapiens]",2,1,3,1,352,39,6.25,0,"cell adhesion;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","AMBP","ENSG00000106927","","Scavenging of heme from plasma","",135,143.6,138.2,104.8,102.7,104.9,1.3341869398207429,0.4159608241365292,1.829357566402931E-4,3.7377013989859638,0.011246947935806367,1.9489653152832855,127]
["High","P02765","Alpha-2-HS-glycoprotein [OS=Homo sapiens]",7,4,33,4,367,39.3,5.72,45.09,"","","","","","","","",2000.8,2034.8,1767.5,1270.7,1377.5,1374,1.442767639600219,0.528838969829573,2.8539755449390426E-3,2.544549752575097,0.03286702220484372,1.483239641783525,678]
["High","P02768-1","Serum albumin [OS=Homo sapiens]",8,6,55,6,609,69.3,6.28,93.09,"stress response;other biological processes","non-structural extracellular;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","ALB","ENSG00000163631","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; VEGFA-VEGFR2 signaling pathway","Cytoprotection by HMOX1; Scavenging of heme from plasma; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Recycling of bile acids and salts; Heme degradation; HDL remodeling; Heme biosynthesis","Thyroid hormone synthesis",2912.3,2701.4,2668.4,2162.9,2159.5,2182.2,1.2732681486947701,0.3485362810252294,1.5136952150922778E-3,2.819961561909122,0.026032890395243403,1.5844776101075906,454]
["High","P02771","Alpha-fetoprotein [OS=Homo sapiens]",3,2,3,2,609,68.6,5.68,8.34,"other metabolic processes;developmental processes;signal transduction","non-structural extracellular;ER/Golgi;other cell component","other molecular function","AFP","ENSG00000081051","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Hippo signaling pathway",180,150,126.5,110.5,131.4,122.1,1.254120879120879,0.32667640978552576,0.1371710889557194,0.8627374136298886,0.31044401813514694,0.5080167040445274,3450]
["High","P02774","vitamin D-binding protein [OS=Homo sapiens]",10,4,11,4,474,52.9,5.54,34.45,"transport","non-structural extracellular","transporter activity;cytoskeletal activity;other molecular function","HEL-S-51","","","","",356.3,316.1,304.6,242.8,250.6,256.7,1.3024930009332092,0.38127562006917326,0.009487119177237036,2.0228656437756665,0.06363868259095085,1.1962788194309006,1164]
["High","P02792","Ferritin light chain [OS=Homo sapiens]",40,6,15,6,175,20,5.78,39.57,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTL","ENSG00000087086","Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Ferroptosis; Necroptosis; Mineral absorption",906.4,955,873.2,377.4,411.5,408.8,2.2832094848459548,1.1910632331427646,4.0051868404362593E-5,4.397377219435481,0.006949444188916958,2.1580499285521895,45]
["High","P03905","NADH-ubiquinone oxidoreductase chain 4 [OS=Homo sapiens]",6,2,2,2,459,51.5,9.35,2.5,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-ND4","ENSG00000198886","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",103.8,97.8,106.5,90.2,113.9,101.8,1.0071918927754167,0.010338575481148578,0.9249097817082699,0.033900627495702745,0.9608429451274841,0.01734759426555537,7516]
["High","P04062","glucosylceramidase [OS=Homo sapiens]",6,3,3,3,536,59.7,7.61,8.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GBA","ENSG00000177628","Sphingolipid pathway","Glycosphingolipid metabolism; Association of TriC/CCT with target proteins during biosynthesis","Other glycan degradation; Sphingolipid metabolism; Metabolic pathways; Lysosome",158.8,174.9,191.7,169.7,186,196.1,0.9521565784704605,-0.07072925621964078,0.5113242730071148,0.2913035904480475,0.6943338997634004,0.15843163047904257,5750]
["Medium","P04150","Glucocorticoid receptor [OS=Homo sapiens]",1,1,1,1,777,85.6,6.38,2.62,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","NR3C1","ENSG00000113580","Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling","Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression","Neuroactive ligand-receptor interaction",29.5,37.5,35.6,45.1,41.8,43.6,0.786206896551724,-0.347019075850193,0.023085093638386355,1.6366683595121465,0.10473469560053496,0.9799094251810713,1721]
["Medium","P04437","T-cell receptor alpha chain V region CTL-L17 [OS=Homo sapiens]",5,1,1,1,139,15.4,8.43,2.06,"","","","","","","","",104.1,91.6,75.3,85.5,96.3,69.5,1.078392359729407,0.10888218036057828,0.5956824833506693,0.22498517058437856,0.7563975979837414,0.12124985897039149,6149]
["High","P04733","Metallothionein-1F [OS=Homo sapiens]",33,2,13,1,61,6.1,7.83,22.3,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1F","ENSG00000198417","Copper homeostasis; Zinc homeostasis","Metallothioneins bind metals","Mineral absorption",609.5,616.3,692.1,628.3,656.6,661.2,0.9855094804994605,-0.02105834497449299,0.757276064842199,0.12074576966585356,0.86571178832912,0.06262666868875075,6830]
["High","P04920-1","Anion exchange protein 2 [OS=Homo sapiens]",8,5,9,5,1241,136.9,6.29,19.31,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC4A2","ENSG00000164889","Proximal tubule transport","Bicarbonate transporters","Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion",135.7,128.4,135.4,131,112.3,143.3,1.0333678220382823,0.04735386560410311,0.6685854483507061,0.17484307998659124,0.8093511908096609,0.09186298996322365,6450]
["High","P05067-8","Isoform APP751 of Amyloid-beta A4 protein [OS=Homo sapiens]",40,20,50,1,751,84.8,4.79,114.1,"","","","APP","","","","",26.5,22.1,22.4,23.1,22.9,22.4,1.0380116959064327,0.05382269950614651,0.5783287242458871,0.23782523676145165,0.7434294828633332,0.1287602196850627,6074]
["High","P05141","ADP/ATP translocase 2 [OS=Homo sapiens]",51,18,174,5,298,32.8,9.69,350.99,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","transporter activity;other molecular function","SLC25A5","ENSG00000005022","Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization","Calcium signaling pathway; cGMP-PKG signaling pathway; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Influenza A; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy",10044.4,10927,9582,8418.5,10021.8,9584,1.0902466787752059,0.12465459553592491,0.2456047230955237,0.6097632857613243,0.4433946076138379,0.35320959290352194,4325]
["High","P05387","60S acidic ribosomal protein P2 [OS=Homo sapiens]",70,5,26,5,115,11.7,4.54,87.36,"protein metabolism;other metabolic processes","cytosol;translational apparatus","other molecular function","RPLP2","ENSG00000177600","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",960,963.2,918.8,990.4,747.2,608.9,1.211165565736203,0.2763960942145174,0.21571733680558666,0.6661149500461111,0.4101098041826201,0.38709984824112814,4107]
["High","P05423","DNA-directed RNA polymerase III subunit RPC4 [OS=Homo sapiens]",29,9,25,9,398,44.4,6.98,52.77,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3D","ENSG00000168495","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",1194.4,1155.1,1110.1,1237.3,1295.4,1232.7,0.9187868486747757,-0.12219788846263563,0.03218703177960017,1.492319071191898,0.12770139437760067,0.8938043606285854,1968]
["High","P05937","Calbindin [OS=Homo sapiens]",15,2,4,2,261,30,4.83,6.53,"developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CALB1","ENSG00000104327","","Amyloid fiber formation","Endocrine and other factor-regulated calcium reabsorption",111.1,113.1,103,84.9,78.4,79.4,1.3481664606510093,0.4309986397906149,1.5823050586631733E-3,2.8007097834666115,0.026342511509684557,1.5793428215230594,469]
["High","P06280","alpha-galactosidase A [OS=Homo sapiens]",25,8,30,8,429,48.7,5.6,70.75,"other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","GLA","ENSG00000102393","Degradation pathway of sphingolipids, including diseases; Ciliary landscape","Neutrophil degranulation; Glycosphingolipid metabolism","Galactose metabolism; Glycerolipid metabolism; Sphingolipid metabolism; Glycosphingolipid biosynthesis; Metabolic pathways; Lysosome",1002.8,1006.6,973.2,982.8,958.3,966.8,1.0256886412875275,0.03659285195608866,0.12294318341520483,0.9102955457152623,0.2907148322549725,0.5365328099834017,3302]
["High","P06733-1","alpha-enolase [OS=Homo sapiens]",81,35,836,30,434,47.1,7.39,1693.12,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","ENO1; HEL-S-17; LOC117800423","ENSAMEG00000029491; ENSG00000074800; ENSGGOG00000010357; ENSPPAG00000003541; ENSPPYG00000001920; ENSPTRG00000000109","Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis","Gluconeogenesis; Glycolysis; Manipulation of host energy metabolism","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway",30743.1,30641.7,31285.5,29514.5,29461,29842.7,1.0433706154819622,0.06125170833127123,5.2710328631283675E-3,2.2781042760956445,0.04537621234322634,1.3431717584971046,907]
["High","P06748","Nucleophosmin [OS=Homo sapiens]",63,19,563,19,294,32.6,4.78,1527.79,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","cytosol;cytoskeleton;translational apparatus;nucleus;other cell component","enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function","NPM1","ENSG00000181163","","TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Nuclear events stimulated by ALK signaling in cancer; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation","",18548.4,18224.7,18673.3,18037,16185.3,16103.7,1.1017446250447087,0.13978985832149016,0.05727457308787993,1.2420381392624233,0.1831285285299617,0.7372439942126515,2442]
["High","P07093-1","Glia-derived nexin [OS=Homo sapiens]",14,4,10,4,398,44,9.29,19.88,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SERPINE2","ENSG00000135919","","Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Dissolution of Fibrin Clot","",347.6,346.9,361.4,247.7,237.6,267.6,1.4024438836498871,0.4879430450588729,5.4029294533528677E-4,3.2673707030548425,0.017218805376236403,1.7639969827607394,245]
["High","P07355","Annexin A2 [OS=Homo sapiens]",69,30,235,30,339,38.6,7.75,501.76,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","ANXA2","ENSG00000182718","Gastrin signaling pathway; CCL18 signaling pathway; Prostaglandin synthesis and regulation","Smooth Muscle Contraction; Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Dissolution of Fibrin Clot","Salmonella infection",9928.9,9803.6,9985.6,8459.8,9124.8,8751.9,1.1283997493972242,0.17427825063252228,0.004860894718605432,2.3132837851430796,0.0434254759300586,1.3622554131188473,874]
["High","P07384","Calpain-1 catalytic subunit [OS=Homo sapiens]",54,34,124,33,714,81.8,5.67,250.54,"protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","CAPN1","ENSG00000014216","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease","Degradation of the extracellular matrix; Neutrophil degranulation; Formation of the cornified envelope; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Protein processing in endoplasmic reticulum; Apoptosis; Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis",4699.5,5099.3,4625.9,5104.8,5487,5287.8,0.9083793042645909,-0.1386332575952752,0.057736372387292456,1.2385505065944333,0.18370236169518317,0.7358852603267835,2454]
["High","P07741-1","Adenine phosphoribosyltransferase [OS=Homo sapiens]",83,12,86,12,180,19.6,6.02,171.04,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","APRT","ENSG00000198931; ENSPPAG00000005769; ENSPTRG00000008466","","Neutrophil degranulation; Purine salvage","Purine metabolism; Metabolic pathways",3326.4,3369.6,3359.3,3094.6,3223.5,3149.4,1.0620860839714812,0.08690070388744432,0.007742698593719909,2.111107646539391,0.05639458080201964,1.248762627237507,1072]
["High","P07951-1","Tropomyosin beta chain [OS=Homo sapiens]",58,26,115,6,284,32.8,4.7,216.72,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","TPM2","ENSANAG00000037556; ENSCANG00000042880; ENSCATG00000041575; ENSCCAG00000023807; ENSG00000198467; ENSMFAG00000002090; ENSMLEG00000037634; ENSMMUG00000016321; ENSMNEG00000031621; ENSNLEG00000004274; ENSPANG00000025431; ENSPPAG00000030835; ENSPTRG00000024321; ENSRBIG00000029128; ENSRROG00000041510; ENSSBOG00000021703","Striated muscle contraction pathway","Striated Muscle Contraction; Smooth Muscle Contraction","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Hypertrophic cardiomyopathy; Dilated cardiomyopathy",1660.4,1768.4,1517.2,1440.2,1306.6,1380.8,1.1982750266498692,0.2609590717712787,0.029612675105426103,1.5285223581950387,0.12233638477416243,0.9124443577096474,1890]
["High","P08069","Insulin-like growth factor 1 receptor [OS=Homo sapiens]",9,10,16,9,1367,154.7,5.8,22.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;transporter activity;kinase activity;other molecular function","IGF1R","ENSG00000140443","MicroRNAs in cardiomyocyte hypertrophy; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Apoptosis; Focal adhesion; MECP2 and associated Rett syndrome; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Ebola virus infection in host; Ras signaling; Breast cancer pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Head and neck squamous cell carcinoma; Endochondral ossification; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Malignant pleural mesothelioma","Extra-nuclear estrogen signaling; IRS-related events triggered by IGF1R; Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R); SHC-related events triggered by IGF1R","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Oocyte meiosis; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Long-term depression; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Pathways in cancer; Transcriptional misregulation in cancer; Proteoglycans in cancer; Glioma; Prostate cancer; Melanoma; Breast cancer; Hepatocellular carcinoma",392.5,344.4,406.4,396.1,400.3,414.3,0.9443297266044436,-0.08263740915673654,0.31501160849410403,0.5016734417277354,0.5160744102228209,0.28728767507953734,4766]
["High","P08195","4F2 cell-surface antigen heavy chain [OS=Homo sapiens]",37,19,75,19,630,68,5.01,176.48,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","transporter activity;nucleic acid binding activity;other molecular function","SLC3A2","ENSG00000168003","mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; Proximal tubule transport; Malignant pleural mesothelioma","Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)","mTOR signaling pathway; Ferroptosis; Protein digestion and absorption",3502.4,3499.4,3427.4,3082.2,3158.6,3177.6,1.1073218381041365,0.14707459588174895,9.0188965464561117E-4,3.0448465947308123,0.020119869781351232,1.6963748344224527,350]
["Medium","P08247","Synaptophysin [OS=Homo sapiens]",5,2,2,2,313,33.8,4.81,2.16,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SYP","ENSG00000102003","Synaptic vesicle pathway","Sensory processing of sound by inner hair cells of the cochlea","",106.7,99,113.2,78.9,80.6,77,1.3484143763213532,0.43126391402550346,0.002910577969793113,2.536020762159088,0.03307975660574181,1.4804376945600028,687]
["High","P08473","Neprilysin [OS=Homo sapiens]",11,6,8,6,750,85.5,5.73,9.23,"protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","MME","ENSG00000196549","Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Alzheimer's disease","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","Renin-angiotensin system; Hematopoietic cell lineage; Protein digestion and absorption; Alzheimer disease",153.7,152,147.8,163.9,174.4,152.4,0.9241899327491337,-0.11373872065234272,0.133053879837621,0.8759724569449702,0.3043904757609565,0.5165689405649736,3413]
["High","P08621-1","U1 small nuclear ribonucleoprotein 70 kDa [OS=Homo sapiens]",50,20,154,20,437,51.5,9.94,380.18,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","SNRNP70; SNRP70","ENSCATG00000016149; ENSG00000104852; ENSGGOG00000008245; ENSMLEG00000030967; ENSPANG00000004068; ENSPPAG00000035067; ENSPTRG00000011277; ENSRROG00000033636","mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway","Spliceosome",6948.1,6395.1,7137.8,6971.2,6801.5,7071.6,0.9825707747441745,-0.025366766198069803,0.6353381576025854,0.19699506070660844,0.7871660321423337,0.10393365488595385,6302]
["High","P08962","CD63 antigen [OS=Homo sapiens]",13,4,35,4,238,25.6,7.81,62.36,"cell adhesion;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","","CD63","ENSG00000135404","Extracellular vesicles in the crosstalk of cardiac cells","Neutrophil degranulation; Platelet degranulation","Lysosome; Proteoglycans in cancer",2122.7,2293.9,2295.9,1857.6,1789.7,1866.2,1.2174662192799492,0.28388174277709494,3.0329869336286285E-3,2.518129460663688,0.03359086805357778,1.4737787729964513,705]
["High","P09001","39S ribosomal protein L3, mitochondrial [OS=Homo sapiens]",30,7,22,7,348,38.6,9.48,40.19,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL3","ENSG00000114686","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",946.9,906.1,919.7,930.7,902.5,949.9,0.9962631597858502,-0.005401218888500621,0.8586526784035884,0.06618247104153467,0.924484295777057,0.03410046180637035,7252]
["Medium","P09382","Galectin-1 [OS=Homo sapiens]",6,1,1,1,135,14.7,5.5,2.09,"stress response;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LGALS1","ENSG00000100097","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",52.2,61.5,65.1,63.4,52.3,39.8,1.1498392282958199,0.20143215616535276,0.37713848741503386,0.4234991450829585,0.5788671731347719,0.23742107805567775,5087]
["High","P09496-2","Isoform Non-brain of Clathrin light chain A [OS=Homo sapiens]",24,5,11,5,218,23.6,4.53,24.57,"","","","CLTA","","","","",521.2,481.7,458.4,770.5,422.4,359.8,0.9411347974496039,-0.08752672189693857,0.8249756332717011,0.08355887871301096,0.9060922414665132,0.04282758828261299,7109]
["High","P09525","annexin A4 [OS=Homo sapiens]",44,13,29,12,319,35.9,6.13,41.2,"signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","enzyme regulator activity;other molecular function","ANXA4","ENSG00000196975","Prostaglandin synthesis and regulation","","",575.4,603.3,525.3,616.9,647.6,634,0.8975506979194098,-0.15593466339325135,0.057115472556540814,1.243246225630337,0.18276951218093063,0.7380962473104309,2440]
["High","P09884","DNA polymerase alpha catalytic subunit [OS=Homo sapiens]",26,30,71,30,1462,165.8,5.85,155.47,"cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLA1","ENSG00000101868","Retinoblastoma gene in cancer; Pyrimidine metabolism; Nucleotide metabolism; DNA replication","Defective pyroptosis; Activation of the pre-replicative complex; G1/S-Specific Transcription; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate","DNA replication",3309.1,3218,3339.1,3465,3334.6,3398.4,0.9674642086683664,-0.04771980513602932,0.1022900458595557,0.9901666266847452,0.2591436333781346,0.5864594564085104,3082]
["Medium","P09958","Furin [OS=Homo sapiens]",1,1,1,1,794,86.6,6.47,2.67,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","FURIN","ENSG00000140564","SARS-CoV-2 altering angiogenesis via NRP1","Potential therapeutics for SARS; Formation of the cornified envelope; Amyloid fiber formation; Collagen degradation; Signaling by PDGF; Signaling by NODAL; Pre-NOTCH Processing in Golgi; Uptake and function of anthrax toxins; Attachment and Entry; Assembly of active LPL and LIPC lipase complexes; Activation of Matrix Metalloproteinases; TGF-beta receptor signaling activates SMADs; Removal of aminoterminal propeptides from gamma-carboxylated proteins; NGF processing; Synthesis and processing of ENV and VPU; Elastic fibre formation; CD163 mediating an anti-inflammatory response","",72.6,64.7,66,81.9,73.3,73.4,0.8893263342082239,-0.16921518836974583,0.08807907410227991,1.0551272593676415,0.23690024477802327,0.6254344905406799,2903]
["High","P0CG38","POTE ankyrin domain family member I [OS=Homo sapiens]",11,10,241,1,1075,121.2,6.21,501.86,"","","","POTEI","ENSG00000196834","","","",928.2,953.7,984.4,780.5,753.4,819.7,1.217836505778382,0.28432046482476236,2.462681309783409E-3,2.6085917856263805,0.030864551632084843,1.5105400276269147,623]
["High","P10070-1","Isoform 1 of Zinc finger protein GLI2 [OS=Homo sapiens]",5,4,5,2,1258,133.2,7.14,12.6,"","","","GLI2","","","","",106.3,106.4,111.9,116.4,109.3,122.1,0.9332949971247845,-0.09959493275861553,0.13507813107136152,0.869414956853696,0.30704222631883277,0.5128018935906299,3435]
["High","P10109","Adrenodoxin, mitochondrial [OS=Homo sapiens]",16,2,10,2,184,19.4,5.83,18.72,"other metabolic processes;other biological processes","mitochondrion","other molecular function","FDX1","ENSG00000137714","","Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin","",168.2,175,165.6,155.6,118,132.1,1.2541286665023414,0.3266853680780823,0.038546356412020054,1.414016667287194,0.1435925338096625,0.8428681409402476,2096]
["High","P10398-1","serine/threonine-protein kinase A-Raf [OS=Homo sapiens]",21,10,14,7,606,67.5,9.01,21.9,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","ARAF","ENSG00000078061; ENSGGOG00000008695; ENSPPAG00000015632; ENSPTRG00000021846","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Common pathways underlying drug addiction; Bladder cancer; MAPK signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Alzheimer's disease; ErbB signaling pathway","Signaling by BRAF and RAF1 fusions; RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; FoxO signaling pathway; Vascular smooth muscle contraction; Natural killer cell mediated cytotoxicity; Long-term potentiation; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Parathyroid hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Pathways in cancer; Proteoglycans in cancer; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer",881.1,862.2,936.6,874,986.1,919.6,0.9640968449832718,-0.05275002025843731,0.44676187082475227,0.3499238991128768,0.6405282202349735,0.1934617314581872,5446]
["High","P10620","Microsomal glutathione S-transferase 1 [OS=Homo sapiens]",23,3,16,3,155,17.6,9.39,26.69,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGST1","ENSG00000008394","Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Oxidative stress response; Metapathway biotransformation Phase I and II","Neutrophil degranulation; Aflatoxin activation and detoxification; Glutathione conjugation","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",876.1,842.2,891.8,719,951.3,847.2,1.036782522343595,0.05211330317627076,0.6767264172128714,0.1695868697322205,0.8154135595058796,0.08862207094417847,6480]
["High","P10809","60 kDa heat shock protein, mitochondrial [OS=Homo sapiens]",83,51,1952,51,573,61,5.87,4312.07,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","HSPD1","ENSG00000144381","Apoptosis-related network due to altered Notch3 in ovarian cancer; Sudden infant death syndrome (SIDS) susceptibility pathways","Mitochondrial protein import; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation","RNA degradation; Type I diabetes mellitus; Legionellosis; Tuberculosis; Lipid and atherosclerosis",42005.4,41535.8,43163.7,43167.6,42084,43298.2,0.9856483635135955,-0.020855047367762603,0.37611131146285326,0.42468360507260905,0.57785854386107,0.23817846112832422,5082]
["High","P11137","microtubule-associated protein 2 [OS=Homo sapiens]",8,10,19,3,1827,199.4,4.91,47.97,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAP2","ENSG00000078018","Melatonin metabolism and effects; MAPK cascade; Sudden infant death syndrome (SIDS) susceptibility pathways","","",657.5,580.4,705.5,589.8,485,510.4,1.2259651778955338,0.2939180015483591,0.0684452896023537,1.1646564346022508,0.20358888427244867,0.691245937685591,2625]
["High","P11177","Pyruvate dehydrogenase E1 component subunit beta, mitochondrial [OS=Homo sapiens]",48,13,113,13,359,39.2,6.65,231.16,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","PDHB","ENSG00000168291","Metabolic reprogramming in colon cancer; Orexin receptor pathway","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Glycolysis / Gluconeogenesis; Citrate cycle (TCA cycle); Pyruvate metabolism; Metabolic pathways; Carbon metabolism; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer; Diabetic cardiomyopathy",5020.4,5019.6,5039.3,4988.3,5217.8,5191.9,0.9793025068190674,-0.030173517310847636,0.2185449512099132,0.6604592220592613,0.4126720626474008,0.3843949312891914,4135]
["High","P11233","Ras-related protein Ral-A [OS=Homo sapiens]",42,9,54,5,206,23.6,7.11,136.81,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","RALA","ENSG00000006451","RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; p38MAPK events","Ras signaling pathway; Rap1 signaling pathway; Phospholipase D signaling pathway; Salmonella infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer",2021,2037.7,2070.1,1882.5,1974.8,1892.3,1.0659524140809793,0.09214303518739411,0.017930489256929916,1.7464078599812667,0.08991731542588874,1.0461566678907517,1557]
["High","P11441","Ubiquitin-like protein 4A [OS=Homo sapiens]",29,4,8,4,157,17.8,8.66,12.29,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;cytosol;nucleus;other cell component","other molecular function","UBL4A","ENSG00000102178","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",203.4,208.1,162.9,217.1,168.5,170.4,1.033093525179856,0.04697086621218152,0.788753596559525,0.10305864744683377,0.883711878596179,0.05368930730809629,6969]
["High","P11717","Cation-independent mannose-6-phosphate receptor [OS=Homo sapiens]",25,50,104,50,2491,274.2,5.94,235.02,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","IGF2R","ENSG00000197081","","Retrograde transport at the Trans-Golgi-Network; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis","Lysosome; Endocytosis",3846.8,3817.6,4066.4,4083,4154.2,4149.4,0.947055689212536,-0.0784788326693723,0.055692429606486876,1.254203835411119,0.17983725821648036,0.7451203272772366,2418]
["High","P12036","Neurofilament heavy polypeptide [OS=Homo sapiens]",4,4,11,2,1026,112.4,6.18,23.38,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","NEFH","ENSG00000100285","Amyotrophic lateral sclerosis (ALS); Physico-chemical features and toxicity-associated pathways","","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",41.7,36.8,30.5,22.3,36.1,28.3,1.257208765859285,0.3302242364424538,0.22200869725299044,0.653630011607944,0.4167934378820268,0.38007912731424215,4159]
["High","P12259","Coagulation factor V [OS=Homo sapiens]",0,1,2,1,2224,251.5,6.05,4.92,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","F5","ENSG00000198734","Blood clotting cascade; Complement and coagulation cascades","COPII-mediated vesicle transport; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Platelet degranulation ; Cargo concentration in the ER; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",124.8,93.9,98,76.1,78.2,97.1,1.2597454256165472,0.3331322176076821,0.13802993727713164,0.8600267093654059,0.3117552069018929,0.5061862842491774,3457]
["High","P12277","Creatine kinase B-type [OS=Homo sapiens]",77,19,172,18,381,42.6,5.59,440.14,"other metabolic processes;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","kinase activity;other molecular function","CKB","ENSG00000166165","","RND3 GTPase cycle; Creatine metabolism","Arginine and proline metabolism; Metabolic pathways",4279.9,4317.2,4614.3,4093.3,3876.7,3861.7,1.1166104617257027,0.1591259781653785,0.02381965769373189,1.6230644839444062,0.10658102422501925,0.9723201105809695,1745]
["High","P12955","xaa-Pro dipeptidase [OS=Homo sapiens]",33,15,47,15,493,54.5,6,105.32,"protein metabolism;other metabolic processes","","other molecular function","PEPD","ENSG00000124299","","","",1642.2,1624.3,1717.4,1510.9,1519.6,1505.4,1.098767609515201,0.13588628705848382,0.006599092007686022,2.1805158164550056,0.051577287683696155,1.2875415000223525,999]
["Medium","P13056-1","Nuclear receptor subfamily 2 group C member 1 [OS=Homo sapiens]",1,1,1,1,603,67.3,6.32,1.83,"signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NR2C1","ENSG00000120798","","Nuclear Receptor transcription pathway; SUMOylation of intracellular receptors","",25.9,18.5,24.1,36,28.8,27.8,0.7397408207343413,-0.43490820541234715,0.0780825879039973,1.1074458012096982,0.21977968505926854,0.6580124532883289,2774]
["High","P13533","myosin-6 [OS=Homo sapiens]",3,5,14,3,1939,223.6,5.73,30.89,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYH6","ENSG00000197616","Cardiac progenitor differentiation; Striated muscle contraction pathway; Acute viral myocarditis; IL-18 signaling pathway","Striated Muscle Contraction","cGMP-PKG signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Thyroid hormone signaling pathway; Hypertrophic cardiomyopathy; Dilated cardiomyopathy; Viral myocarditis",128.4,120.9,114.7,119.6,91.3,109,1.137855579868709,0.18631745797038501,0.18364741503498797,0.7360151802723577,0.37283385766853516,0.4284846555161833,3846]
["Medium","P13682","Zinc finger protein 35 [OS=Homo sapiens]",2,1,1,1,527,59.1,8.09,0,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF35","ENSG00000169981; ENSG00000281306","","","",34.7,36,41.6,29.8,42.9,42.2,0.9773716275021758,-0.03302087024551216,0.8641638736670103,0.06340389330714577,0.9274764983631638,0.03269708630645525,7275]
["Medium","P13726-1","tissue factor [OS=Homo sapiens]",5,2,4,1,295,33,7.03,7.18,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","F3","ENSG00000117525","Blood clotting cascade; VEGFA-VEGFR2 signaling pathway; Macrophage markers; STING pathway in Kawasaki-like disease and COVID-19; Complement and coagulation cascades","NGF-stimulated transcription; Extrinsic Pathway of Fibrin Clot Formation","Complement and coagulation cascades; AGE-RAGE signaling pathway in diabetic complications",161.7,170,167.1,159.9,165.1,169.8,1.008084074373484,0.01161596485330003,0.7403623884954271,0.13055565216088477,0.8564073376847845,0.06731962033327427,6750]
["High","P13984","General transcription factor IIF subunit 2 [OS=Homo sapiens]",58,13,28,13,249,28.4,9.23,46.49,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","GTF2F2","ENSG00000188342","Eukaryotic transcription initiation","Estrogen-dependent gene expression; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","Basal transcription factors",1357.4,1351,1468.7,1467.3,1285.8,1438.4,0.996564475724681,-0.004964947325161668,0.9471498647877534,0.02358129839805721,0.9737124613907543,0.011569271938226952,7595]
["Medium","P14415","sodium/potassium-transporting ATPase subunit beta-2 [OS=Homo sapiens]",3,1,1,1,290,33.3,8.31,2.01,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ATP1B2","ENSG00000129244","Calcium regulation in cardiac cells","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS; Basigin interactions","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption",43.9,26.5,49.6,30.3,32.2,32.2,1.2671594508975712,0.34159807502749584,0.29329758300854725,0.5326915159160582,0.49418807253576535,0.30610774071137964,4634]
["High","P14550","alcohol dehydrogenase [NADP(+)] [OS=Homo sapiens]",66,20,102,19,325,36.6,6.79,241.94,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","AKR1A1","ENSG00000117448","Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II","Glutathione conjugation; Formation of xylulose-5-phosphate","Glycolysis / Gluconeogenesis; Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Glycerolipid metabolism; Pyruvate metabolism; Metabolic pathways; Biosynthesis of cofactors; Chemical carcinogenesis",4447,4521.7,4492.1,4178,4172.4,4018.9,1.0882426653084654,0.12200029647889102,2.9857752997901497E-3,2.5249428790400428,0.03349559416776076,1.4750123139919693,696]
["High","P14859-1","POU domain, class 2, transcription factor 1 [OS=Homo sapiens]",15,8,23,8,743,76.4,6.81,50.59,"other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","POU2F1","ENSG00000143190","Integrated cancer pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling","Herpes simplex virus 1 infection; Lipid and atherosclerosis",615.8,584.5,602.3,647.5,615.5,644.7,0.9449074802117734,-0.08175501885960784,0.06244378452706748,1.2045107835498148,0.19355342182903648,0.7131991463892923,2519]
["High","P14868","Aspartate--tRNA ligase, cytoplasmic [OS=Homo sapiens]",65,29,143,29,501,57.1,6.55,308.42,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","DARS1","ENSG00000115866","Alanine and aspartate metabolism","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",6834.3,6921.7,6714.3,6693.7,7382.6,7153.3,0.9642338998379621,-0.05254494303290889,0.2970544388289214,0.5271639536575903,0.49826016291648084,0.3025438343163164,4655]
["High","P15260","Interferon gamma receptor 1 [OS=Homo sapiens]",4,2,3,2,489,54.4,4.91,3.74,"stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","IFNGR1","ENSG00000027697","Immune response to tuberculosis; Selective expression of chemokine receptors during T-cell polarization; Overview of interferons-mediated signaling pathway; Neuroinflammation and glutamatergic signaling; Type II interferon signaling (IFNG)","Potential therapeutics for SARS; Regulation of IFNG signaling","Cytokine-cytokine receptor interaction; HIF-1 signaling pathway; Necroptosis; Osteoclast differentiation; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Th1 and Th2 cell differentiation; Th17 cell differentiation; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Inflammatory bowel disease",95,94.5,96.8,87.7,66,80.8,1.2208955223880598,0.2879397475966141,0.05514100758398527,1.2585253023548943,0.17872187099035158,0.7478222976946024,2409]
["High","P15559-1","NAD(P)H dehydrogenase [quinone] 1 [OS=Homo sapiens]",31,7,15,7,274,30.8,8.88,40.65,"cell-cell signaling;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","NQO1","ENSG00000181019; ENSGGOG00000003294; ENSPTRG00000008284","Dopamine metabolism; Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Interactions between LOXL4 and oxidative stress pathway; Benzene metabolism; Oxidative stress response; NRF2-ARE regulation; Male infertility; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Estrogen metabolism","Regulation of ornithine decarboxylase (ODC)","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Pathways in cancer; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",937.6,957.1,876.1,857.9,982.1,871.1,1.022020582051566,0.031424250409320724,0.6896947168420235,0.16134310075477906,0.8234153438994678,0.08438104442041097,6540]
["High","P16050","arachidonate 15-lipoxygenase [OS=Homo sapiens]",3,2,2,2,662,74.8,6.58,4.95,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","ALOX15","ENSG00000161905","Eicosanoid synthesis; Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence","Interleukin-4 and Interleukin-13 signaling; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of E-series 18(R)-resolvins; Biosynthesis of DPAn-3-derived protectins and resolvins; Biosynthesis of DPAn-6 SPMs","Arachidonic acid metabolism; Linoleic acid metabolism; Metabolic pathways; Ferroptosis; Necroptosis; Serotonergic synapse",148.3,131.1,132.5,133.3,129.9,110.6,1.1019261637239162,0.1400275571230983,0.2295585833275626,0.6391064640737144,0.42503993801792955,0.37157026042994246,4217]
["High","P16083","Ribosyldihydronicotinamide dehydrogenase [quinone] [OS=Homo sapiens]",55,9,27,9,231,25.9,6.29,54.3,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","NQO2","ENSG00000124588","Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling","Phase I - Functionalization of compounds","",977.9,1015.7,1078.6,1133.6,1107.4,1125.1,0.912688274263985,-0.13180589838631543,0.032091236175778144,1.4936135532697563,0.1274508504885431,0.8946572621072378,1966]
["High","P16383-1","GC-rich sequence DNA-binding factor 2 [OS=Homo sapiens]",19,11,17,11,781,89.3,5.99,39.09,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity","GCFC2","ENSG00000005436","","mRNA Splicing - Major Pathway","",551,504.7,532.1,706.2,596.4,648.3,0.8138807729765751,-0.2971106282014115,0.024582391043601683,1.609375877082642,0.10918049446441522,0.9618549431617598,1758]
["High","P16435","NADPH--cytochrome P450 reductase [OS=Homo sapiens]",55,33,95,33,677,76.6,5.58,193.45,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","POR","ENSG00000127948","Oxidation by cytochrome P450; Ferroptosis","Cytochrome P450 - arranged by substrate type","",4365.8,4435.4,4270.1,3688.7,4023.7,3925.7,1.1231472491214203,0.16754708326038448,0.012370076463649318,1.907627615840699,0.07278489602725989,1.1379587340464992,1327]
["High","P16989-1","Y-box-binding protein 3 [OS=Homo sapiens]",66,17,93,12,372,40.1,9.77,253.02,"stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CSDA; YBX3","ENSG00000060138","RalA downstream regulated genes; Apoptosis-related network due to altered Notch3 in ovarian cancer","","Tight junction",2162.5,2110.2,2134.5,2427.9,2222.2,2254.6,0.9279476298753021,-0.10788470790860721,0.06485606085986319,1.1880494324557738,0.19719475202251238,0.7051046471939542,2568]
["High","P17081","Rho-related GTP-binding protein RhoQ [OS=Homo sapiens]",9,2,16,1,205,22.6,6.32,40.42,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","other molecular function","RHOQ","ENSG00000119729","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling","RHOQ GTPase cycle; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases regulate CFTR trafficking","Insulin signaling pathway",32.1,46.1,35.9,44.2,28.6,40.6,1.0061728395061726,8.878151346452548E-3,0.9722375359159354,0.012227615799560429,0.9857460953683449,0.006234934532030816,7701]
["High","P17096-2","Isoform HMG-Y of High mobility group protein HMG-I/HMG-Y [OS=Homo sapiens]",49,5,11,1,96,10.7,10.32,23.63,"","","","HMGA1","","","","",612,767.6,597.8,646.9,577,463.2,1.1720704166913638,0.22905924788274074,0.273573921193264,0.562925304691945,0.47373368300665464,0.32446573533988016,4509]
["High","P17600-2","Isoform IB of Synapsin-1 [OS=Homo sapiens]",24,11,19,11,669,70,9.88,29.56,"","","","SYN1","","","","",428.4,412.2,438.9,369.8,372.7,368.1,1.152079956780119,0.20424084633507864,2.0313217548397753E-3,2.6922212802958523,0.029048645168111658,1.5368741183419543,546]
["High","P17844","probable ATP-dependent RNA helicase DDX5 [OS=Homo sapiens]",56,38,292,29,614,69.1,8.92,601.5,"RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX5","ENSG00000108654","Ciliary landscape","Estrogen-dependent gene expression; mRNA Splicing - Major Pathway; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome; SUMOylation of transcription cofactors","Spliceosome; Transcriptional misregulation in cancer; Proteoglycans in cancer",13007.5,13367.4,13044.2,13380.2,14092.3,14029.1,0.9498212117123197,-0.07427211960239587,0.05267731233688772,1.2783763913988515,0.1741339774455628,0.7591164800177121,2362]
["High","P17858-1","ATP-dependent 6-phosphofructokinase, liver type [OS=Homo sapiens]",44,26,65,22,780,85,7.5,161.78,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;other cell component","kinase activity;other molecular function","PFKL","ENSG00000141959; ENSPTRG00000022972","Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Insulin signaling; Glycolysis and gluconeogenesis","Neutrophil degranulation; Glycolysis","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Galactose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway; AMPK signaling pathway; Thyroid hormone signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer",3129.6,3260.1,3089.5,2956.6,3303.1,3017.5,1.0217738110636831,0.03107586381683062,0.6004912055803103,0.22149334862062664,0.759908481875375,0.11923870799523287,6170]
["High","P18085","ADP-ribosylation factor 4 [OS=Homo sapiens]",79,10,76,6,180,20.5,7.14,177.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARF4","ENSG00000168374","VEGFA-VEGFR2 signaling pathway","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; VxPx cargo-targeting to cilium","Endocytosis",1810.7,2181.8,1760.9,1607.9,1892.5,1693.3,1.1077651770414154,0.1476520927389039,0.30121067892723397,0.5211296350046816,0.5017821593906214,0.2994847838662563,4687]
["High","P18583-5","Isoform D of Protein SON [OS=Homo sapiens]",23,38,165,8,2459,266.9,5.73,368.2,"","","","SON","","","","",5114,4983.6,5239,5832.7,5505.7,5583.1,0.9063380905948054,-0.14187877680292416,0.012754535798956955,1.8943353429044505,0.07398767869112623,1.130840598133773,1346]
["High","P18669","Phosphoglycerate mutase 1 [OS=Homo sapiens]",81,19,241,19,254,28.8,7.18,546.26,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","PGAM1","ENSG00000171314","Cori cycle; Metabolic reprogramming in colon cancer; Glycolysis and gluconeogenesis","Neutrophil degranulation; Glycolysis; Gluconeogenesis","Glycolysis / Gluconeogenesis; Glycine, serine and threonine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Glucagon signaling pathway; Central carbon metabolism in cancer",9104.9,8908.8,9994.2,9879.3,9036.1,9443.6,0.9876194506153247,-0.01797284505111515,0.7910847023865933,0.10177701358237083,0.8842933938775263,0.05340361937393613,6985]
["High","P19012","Keratin, type I cytoskeletal 15 [OS=Homo sapiens]",12,8,31,1,456,49.2,4.77,73.53,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","KRT15","ENSG00000171346","","Formation of the cornified envelope","Estrogen signaling pathway; Staphylococcus aureus infection",31.6,40.8,33.6,32.5,37.6,33,1.0281280310378274,0.04001993208245315,0.7796949053735083,0.10807530350588813,0.8784787620716238,0.05626873345905946,6930]
["High","P19086","guanine nucleotide-binding protein G(z) subunit alpha [OS=Homo sapiens]",4,1,1,1,355,40.9,7.61,3.2,"signal transduction","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus","signal transduction activity or receptor binding;other molecular function","GNAZ","ENSG00000128266","Corticotropin-releasing hormone signaling pathway; G protein signaling pathways; Purinergic signaling; Calcium regulation in cardiac cells","G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; ADORA2B mediated anti-inflammatory cytokines production","Long-term depression",28.3,33.1,36.2,20.7,29.7,29.8,{"$f":"AVERAGE(T1474:V1474)/AVERAGE(W1474:Y1474)","v":1.2169576059850375},{"$f":"LOG(Z1474,2)","v":0.28327891110796616},{"$f":"TTEST(T1474:V1474,W1474:Y1474,2,2)","v":0.2009059352246121},{"$f":"-LOG10(AB1474)","v":0.6970072330017615},{"$f":"AB1474*7808/AF1474","v":0.3924627326078987},{"$f":"-LOG10(AD1474)","v":0.406201576603231},3997]
["High","P19367-1","Hexokinase-1 [OS=Homo sapiens]",46,39,161,36,917,102.4,6.8,376.43,"other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion","kinase activity;other molecular function","HK1","ENSG00000156515","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Glycolysis and gluconeogenesis; Glucuronidation","Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)","Glycolysis / Gluconeogenesis; Fructose and mannose metabolism; Galactose metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Neomycin, kanamycin and gentamicin biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of nucleotide sugars; HIF-1 signaling pathway; Insulin signaling pathway; Type II diabetes mellitus; Carbohydrate digestion and absorption; Shigellosis; Central carbon metabolism in cancer",8303.4,8614,7733.5,7989.1,8780.4,8633.2,0.9704047207580296,-0.04334152608842731,0.5183798877135413,0.2853518567217038,0.700624920073971,0.1545144196044811,5777]
["High","P19793","retinoic acid receptor RXR-alpha [OS=Homo sapiens]",11,4,5,4,462,50.8,7.8,7.86,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RXRA","ENSG00000186350","Vitamin D metabolism; Energy metabolism; Nuclear receptors; Adipogenesis; Liver X receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Vitamin D receptor pathway; PPAR-alpha pathway; Farnesoid X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Prion disease pathway; PI3K/AKT/mTOR - VitD3 signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Vitamins A and D - action mechanisms; Nonalcoholic fatty liver disease; Vitamin D in inflammatory diseases; Small cell lung cancer; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Vitamin A and carotenoid metabolism","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Regulation of pyruvate dehydrogenase (PDH) complex; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; SUMOylation of intracellular receptors; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Endogenous sterols; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Signaling by Retinoic Acid; Nuclear Receptor transcription pathway; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Recycling of bile acids and salts; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; Transcriptional regulation of granulopoiesis; RORA activates gene expression; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis","PPAR signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation; Thyroid hormone signaling pathway; Adipocytokine signaling pathway; Parathyroid hormone synthesis, secretion and action; Non-alcoholic fatty liver disease; Bile secretion; Hepatitis C; Pathways in cancer; Transcriptional misregulation in cancer; Chemical carcinogenesis; Thyroid cancer; Small cell lung cancer; Non-small cell lung cancer; Gastric cancer; Lipid and atherosclerosis",124.5,118.8,126.3,166.2,179,182.2,0.7007963594994313,-0.5129328144485025,0.000615668499264973,3.210653066556929,0.017608570118171827,1.7542759089390498,273]
["High","P20073-1","Annexin A7 [OS=Homo sapiens]",36,16,55,16,488,52.7,5.68,88.88,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ANXA7","ENSG00000138279","","","Amyotrophic lateral sclerosis",1883.9,1862.1,1775,1712.9,1877,1756.7,1.0326188605842965,0.04630785399918322,0.38223875198077156,0.41766528557439053,0.5830279694209541,0.23431061046600057,5119]
["High","P20337","Ras-related protein Rab-3B [OS=Homo sapiens]",48,8,31,6,219,24.7,5.02,55.97,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3B","ENSG00000169213","Intracellular trafficking proteins involved in CMT neuropathy","RAB geranylgeranylation","",773.8,877.4,811.9,818.4,927.2,886.7,0.9357216122782357,-0.09584871927122983,0.26781181693799694,0.572170264076286,0.4672792551177386,0.33042349906958135,4475]
["High","P20340-2","Isoform 2 of Ras-related protein Rab-6A [OS=Homo sapiens]",53,14,46,10,208,23.5,5.54,85.21,"","","","RAB6A","","","","",3738.3,3900.2,3563.6,3454.7,4103,3765.6,0.9892964065245998,-0.015525258275331319,0.857435683260272,0.06679844674028755,0.9241935139282446,0.03423708372367294,7244]
["High","P20936-1","ras GTPase-activating protein 1 [OS=Homo sapiens]",10,8,17,8,1047,116.3,6.54,37.16,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RASA1","ENSG00000145715","PDGF pathway; T cell receptor and co-stimulatory signaling; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; EPO receptor signaling","Regulation of RAS by GAPs; VEGFR2 mediated cell proliferation; EPHB-mediated forward signaling; Downstream signal transduction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases","MAPK signaling pathway; Ras signaling pathway; Axon guidance",553.8,610.6,598.4,553.1,540.2,550.5,1.0723932351867622,0.10083402373067522,0.08860183005825671,1.0525573077292663,0.2378147435870981,0.62376122431769,2909]
["High","P21283","V-type proton ATPase subunit C 1 [OS=Homo sapiens]",37,14,26,14,382,43.9,7.46,50.96,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity","ATP6V1C1","ENSG00000155097","Proximal tubule transport","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",1794.5,1821.8,1785.8,1677,1686.1,1693.7,1.0682842904603702,0.09529562629414459,6.3324097877266554E-4,3.198430988504897,0.017785415691571844,1.7499359797643381,278]
["High","P21709","Ephrin type-A receptor 1 [OS=Homo sapiens]",13,9,18,9,976,108.1,6.64,29.06,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","EPHA1","ENSG00000146904; ENSG00000284816","","EPHA-mediated growth cone collapse; EPH-ephrin mediated repulsion of cells; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","Axon guidance",1194.4,1186.5,1188.2,1169.3,1204.4,1237.1,0.9884513127284813,-0.016758188735653625,0.5198286301535028,0.2841398049133634,0.7014901389973297,0.1539784295666921,5786]
["High","P21926","CD9 antigen [OS=Homo sapiens]",30,8,35,8,228,25.4,7.15,61.17,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","CD9","ENSG00000010278","Vitamin D receptor pathway","Platelet degranulation ; Uptake and function of diphtheria toxin; Acrosome Reaction and Sperm:Oocyte Membrane Binding","Hematopoietic cell lineage",1507.8,1628.1,1578.8,1847.8,1773.9,1827.6,0.8651936946029766,-0.20890494368613502,0.004054144498125574,2.3921007762102984,0.03903176355285386,1.4085818257628189,811]
["High","P22087","rRNA 2'-O-methyltransferase fibrillarin [OS=Homo sapiens]",53,19,122,16,321,33.8,10.18,265.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","FBL","ENSG00000105202; ENSG00000280548","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",5479.6,5578.7,5603.5,5179.4,5688.8,5685.7,1.006518101474577,0.009373118282874187,0.8458707670446011,0.07269598382459301,0.9189590857220321,0.03670382402270548,7187]
["High","P22307-1","Non-specific lipid-transfer protein [OS=Homo sapiens]",30,13,48,13,547,59,6.89,87.75,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","SCP2","ENSG00000116171","PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; DNA damage response (only ATM dependent)","TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism","Primary bile acid biosynthesis; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome",1993.7,2099.9,1778.1,2093,1924.5,1869.9,0.9973332880388629,-0.00385239101643814,0.9661959818951745,0.014934772939730823,0.9831953898915057,0.007360166481828106,7673]
["High","P22626","heterogeneous nuclear ribonucleoproteins A2/B1 [OS=Homo sapiens]",91,30,462,27,353,37.4,8.95,1127.2,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPA2B1","ENSG00000122566","mRNA processing","mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Processing of Capped Intron-Containing Pre-mRNA","Amyotrophic lateral sclerosis",20566.6,19888.9,21960.7,22637.4,22507.7,23059.2,0.9151358492059883,-0.12794217178786613,0.03795911858003535,1.4206838805511506,0.14249269128505576,0.8462074108552767,2080]
["High","P23142","Fibulin-1 [OS=Homo sapiens]",15,8,12,8,703,77.2,5.22,29.01,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;extracellular matrix","signal transduction activity or receptor binding;enzyme regulator activity;extracellular structural activity;other molecular function","FBLN1","ENSG00000077942","","Molecules associated with elastic fibres","",203.2,269.3,254.5,237.6,250.1,258.9,0.973747656040718,-0.03838014449611299,0.7708292846349372,0.11304179438793067,0.8731517560466545,0.05891026822348201,6893]
["High","P23368-1","NAD-dependent malic enzyme, mitochondrial [OS=Homo sapiens]",41,14,61,14,584,65.4,7.61,109.36,"other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","ME2","ENSG00000082212","TCA cycle in senescence","Citric acid cycle (TCA cycle)","Pyruvate metabolism; Carbon metabolism",1505.7,1553,1489.3,1553.6,1693.5,1631.1,0.932311098355951,-0.10111665377954694,0.06969614106423275,1.1567912672521325,0.20574195441570106,0.6866771389647017,2645]
["High","P23458","Tyrosine-protein kinase JAK1 [OS=Homo sapiens]",4,4,6,4,1154,133.2,7.55,12.61,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK1","ENSG00000162434","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-17 signaling pathway; Type III interferon signaling; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Overview of interferons-mediated signaling pathway; Measles virus infection; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; TGF-beta receptor signaling in skeletal dysplasias; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; IL-2 signaling pathway; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; Malignant pleural mesothelioma; TGF-beta receptor signaling; Interferon type I signaling pathways; Type II interferon signaling (IFNG)","Potential therapeutics for SARS; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Interleukin-4 and Interleukin-13 signaling; Interleukin-6 signaling; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; IL-6-type cytokine receptor ligand interactions; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-27 signaling; ISG15 antiviral mechanism; Interleukin-10 signaling; Interleukin-7 signaling; Regulation of IFNA signaling; Interleukin-2 signaling; Other interleukin signaling; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling","EGFR tyrosine kinase inhibitor resistance; PI3K-Akt signaling pathway; Necroptosis; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; NOD-like receptor signaling pathway; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Pancreatic cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer",171.1,165.7,171.1,146.6,144.7,162,1.1204500330906684,0.16407831273081255,0.03429593351863751,1.4647573713599402,0.13329151264983657,0.8751975034495539,2009]
["High","P23511","Nuclear transcription factor Y subunit alpha [OS=Homo sapiens]",5,1,7,1,347,36.9,8.94,6.86,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFYA","ENSG00000001167","Sterol regulatory element-binding proteins (SREBP) signaling; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways","ATF4 activates genes in response to endoplasmic reticulum  stress; PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF6 (ATF6-alpha) activates chaperone genes","Antigen processing and presentation; Spinocerebellar ataxia; Tuberculosis",94.9,96.5,108,98.9,93.4,93.2,1.0486865148861646,0.06858347580821156,0.3641166483267738,0.4387594635786762,0.5655505848687985,0.247528544148116,5027]
["High","P24385","G1/S-specific cyclin-D1 [OS=Homo sapiens]",16,3,3,2,295,33.7,5.02,9.57,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCND1","ENSG00000110092","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Leptin signaling pathway; IL-7 signaling pathway; Glioblastoma signaling pathways; Spinal cord injury; Retinoblastoma gene in cancer; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Mammary gland development pathway - Puberty (Stage 2 of 4); Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Bladder cancer; Mesodermal commitment pathway; Vitamin D receptor pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; Focal adhesion; Copper homeostasis; Photodynamic therapy-induced NF-kB survival signaling; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; Non-small cell lung cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Wnt signaling; Acute viral myocarditis; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; G1 to S cell cycle control; Hippo-Merlin signaling dysregulation; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Melanoma; FGF23 signaling in hypophosphatemic rickets and related disorders; EGFR tyrosine kinase inhibitor resistance; Influence of laminopathies on Wnt signaling; Development of ureteric collection system; Malignant pleural mesothelioma; Notch signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)","Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Cyclin D associated events in G1; Interleukin-4 and Interleukin-13 signaling; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Transcriptional Regulation by VENTX; RMTs methylate histone arginines; Transcriptional regulation by RUNX2; RUNX3 regulates WNT signaling; RUNX3 regulates p14-ARF; PTK6 Regulates Cell Cycle; Regulation of RUNX1 Expression and Activity","Endocrine resistance; FoxO signaling pathway; Cell cycle; p53 signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Cellular senescence; Wnt signaling pathway; Hedgehog signaling pathway; Apelin signaling pathway; Hippo signaling pathway; Focal adhesion; Tight junction; JAK-STAT signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Alcoholic liver disease; Hepatitis C; Measles; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Viral myocarditis",59.9,62.3,61.6,47.3,48.7,46.1,1.2934553131597464,0.37123021204625384,1.7814048113141392E-4,3.7492373790527806,0.01112736701339264,1.9536075874022019,125]
["Low","P24864-1","G1/S-specific cyclin-E1 [OS=Homo sapiens]",2,1,1,1,410,47,6.04,0,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNE1","ENSG00000105173","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; ATM signaling pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Malignant pleural mesothelioma; ID signaling pathway; DNA damage response","CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; G1/S-Specific Transcription; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); RHOBTB3 ATPase cycle; DNA Damage/Telomere Stress Induced Senescence; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle","Cell cycle; Oocyte meiosis; p53 signaling pathway; PI3K-Akt signaling pathway; Cellular senescence; Cushing syndrome; Hepatitis B; Measles; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Prostate cancer; Small cell lung cancer; Gastric cancer",20.5,21.1,18.9,26.3,29.2,30.4,0.7043073341094296,-0.5057229889765067,3.6044401186249436E-3,2.443162185112475,0.036645141206020256,1.435983600485352,768]
["High","P25205","DNA replication licensing factor mcm3 [OS=Homo sapiens]",65,46,326,46,808,90.9,5.77,658.4,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3","ENSG00000112118","Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Unwinding of DNA","DNA replication; Cell cycle",10862.3,10650.6,11063.1,12050.6,12015.6,12105.2,0.9006010273309852,-0.15103997149977402,6.0042678856154412E-4,3.221539939571806,0.017691065528635988,1.7522460088499783,265]
["High","P25490","Transcriptional repressor protein YY1 [OS=Homo sapiens]",28,9,22,9,414,44.7,6.25,49.12,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","YY1","ENSG00000100811","Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Malignant pleural mesothelioma","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; UCH proteinases; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors","",949.6,918.5,932.1,1069.5,991.2,1014.3,0.9106341463414634,-0.13505653731602718,0.021257968066260534,1.672478249680265,0.09915305535326298,1.003693898678871,1674]
["High","P25788-1","Proteasome subunit alpha type-3 [OS=Homo sapiens]",40,13,55,13,255,28.4,5.33,117.92,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMA3","ENSCANG00000039836; ENSCATG00000039369; ENSCJAG00000018732; ENSCSAG00000014435; ENSG00000100567; ENSGGOG00000015814; ENSMFAG00000002833; ENSMLEG00000041984; ENSMMUG00000003509; ENSMNEG00000035144; ENSNLEG00000013092; ENSPANG00000007163; ENSPPAG00000035468; ENSPPYG00000005855; ENSPTRG00000006390; ENSRROG00000040700; ENSSBOG00000021565","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",3988.1,4147.5,3849.6,3829.2,4265.8,4061.2,0.9859331040950297,-0.02043833232516362,0.7278577956205164,0.1379534621841123,0.8482259206276108,0.07148846022630333,6700]
["High","P26358-1","DNA (cytosine-5)-methyltransferase 1 [OS=Homo sapiens]",46,63,199,1,1616,183.1,7.75,415.46,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT1","ENSG00000130816","Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency","NoRC negatively regulates rRNA expression; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer",301.6,245.6,301.8,303.6,264.5,270.6,1.0122809109335877,0.01760969771401373,0.8850849236054175,0.05301505689114775,0.9392148795203995,0.02723503572762055,7358]
["High","P26572","alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [OS=Homo sapiens]",5,2,2,2,445,50.8,9.16,6.61,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MGAT1","ENSG00000131446","","Maturation of spike protein; Maturation of spike protein; N-glycan trimming and elongation in the cis-Golgi","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways",216.2,204.1,201.6,165.9,213.8,199.8,1.0731665228645384,0.10187395593673677,0.397059258722997,0.40114467254203806,0.5961997484825309,0.22460821151820182,5200]
["High","P26641","elongation factor 1-gamma [OS=Homo sapiens]",72,29,252,29,437,50.1,6.67,477.94,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","EEF1G","ENSG00000254772","Translation factors","Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation","Legionellosis",9989.6,10260.4,9826.1,9422.1,9798.8,9524,1.0463108238330974,0.06531149153718883,0.05882579069372661,1.2304322266404324,0.18648468280008823,0.7293568338209002,2463]
["High","P27348","14-3-3 protein theta [OS=Homo sapiens]",69,21,560,15,245,27.7,4.78,1098.18,"transport;signal transduction;other biological processes","cytosol;other cell component","other molecular function","YWHAQ","ENSG00000134308","Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria","Cell cycle; Oocyte meiosis; PI3K-Akt signaling pathway; Hippo signaling pathway; Hepatitis C; Hepatitis B; Viral carcinogenesis",15400.8,15655.4,14951.8,14735.5,15148.2,13963.2,1.049287406863427,0.06940989589897098,0.14886111949114297,0.8272187192753728,0.32815009062305034,0.48392747147079335,3542]
["High","P27635","60S ribosomal protein L10 [OS=Homo sapiens]",46,11,154,11,214,24.6,10.08,304.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPL10","ENSG00000147403","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",4775.9,4649.4,4292.8,4232.8,3773.5,3761,1.1657814451913353,0.2212973447194172,0.037479021220986106,1.426211759403129,0.14157532544434423,0.8490124313717817,2067]
["High","P27816-5","Isoform 5 of Microtubule-associated protein 4 [OS=Homo sapiens]",42,29,83,1,809,85.2,7.71,105.85,"","","","MAP4","","","","",135.4,125.3,128.9,115,140.4,126.1,1.0212319790301443,0.030310620360449517,0.7504315071690176,0.1246889402174922,0.8624329125663364,0.06427467809286598,6794]
["High","P28070","Proteasome subunit beta type-4 [OS=Homo sapiens]",48,8,60,8,264,29.2,5.97,122.95,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","other molecular function","PSMB4","ENSG00000159377","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of RUNX2 expression and activity; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint; UCH proteinases; Regulation of RUNX3 expression and activity; Regulation of ornithine decarboxylase (ODC); ROS sensing by NFE2L2; Regulation of PTEN stability and activity; Regulation of RAS by GAPs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",1152.3,1169.5,1158.7,1109.3,1254.4,1162.5,0.9870398729510523,-0.0188197292058526,0.7391653832733702,0.13125838026926118,0.8554028920406811,0.06782928576592036,6747]
["Low","P28332-1","Alcohol dehydrogenase 6 [OS=Homo sapiens]",3,1,1,1,368,39.1,7.77,0,"","","","","","","","",80.4,101.1,88.2,76.6,95.3,93.8,1.015054572826496,0.02155729374509671,0.8830864468910715,0.0539967804879865,0.93747640752216,0.028039652892899995,7355]
["High","P28799","Granulins [OS=Homo sapiens]",4,2,3,2,593,63.5,6.83,6.9,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GRN","ENSG00000030582","IL-18 signaling pathway","Neutrophil degranulation","",312.1,278,290.1,240.5,215.6,254.8,1.2381488254325503,0.3081847368534155,0.020570023971516627,1.6867652021948565,0.09745797765145743,1.011182604897318,1648]
["High","P29084","transcription initiation factor iie subunit beta [OS=Homo sapiens]",41,10,40,9,291,33,9.66,62.58,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","GTF2E2","ENSG00000197265","Eukaryotic transcription initiation","RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors; Viral carcinogenesis",1214.9,1170.3,1252.1,1255.1,1085.8,1199.6,1.0273407710775315,0.038914805996396455,0.5899466581247479,0.2291872546788079,0.752663971672881,0.12339887216573368,6120]
["High","P29353","SHC-transforming protein 1 [OS=Homo sapiens]",31,12,25,12,583,62.8,6.44,61.33,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","signal transduction activity or receptor binding;other molecular function","SHC1","ENSG00000160691","IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; IL-4 signaling pathway; p38 MAPK signaling pathway; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; EGF/EGFR signaling pathway; Fragile X syndrome; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Malignant pleural mesothelioma; EPO receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)","Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Interleukin receptor SHC signaling; RET signaling; RAF/MAP kinase cascade; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; Signaling by CSF3 (G-CSF); XBP1(S) activates chaperone genes; SHC1 events in EGFR signaling; Integrin signaling; Erythropoietin activates RAS; Signalling to RAS; Signal attenuation; Interleukin-2 signaling; Interleukin-15 signaling","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; ErbB signaling pathway; Ras signaling pathway; Chemokine signaling pathway; Phospholipase D signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Insulin signaling pathway; Estrogen signaling pathway; Prolactin signaling pathway; Relaxin signaling pathway; Growth hormone synthesis, secretion and action; Alcoholism; Bacterial invasion of epithelial cells; MicroRNAs in cancer; Glioma; Chronic myeloid leukemia; Breast cancer; Hepatocellular carcinoma; Gastric cancer",1212.2,1209.1,1158.7,1116.7,1218.1,1155,1.02584675339561,0.03681522935720774,0.429860925115096,0.3666720309894566,0.6254852969248359,0.2037828946667414,5366]
["High","P29401","Transketolase [OS=Homo sapiens]",70,36,535,36,623,67.8,7.66,1322.77,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","TKT","ENSG00000163931","Pentose phosphate metabolism; VEGFA-VEGFR2 signaling pathway; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways","Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",23445.5,23953.5,23678.6,23548.3,25163.1,25030.1,0.9638751584928433,-0.053081794787534234,0.17415312304344194,0.759068733043975,0.36106945956537295,0.44240924406598564,3766]
["High","P30043","flavin reductase (NADPH) [OS=Homo sapiens]",35,5,13,5,206,22.1,7.65,29.56,"other metabolic processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","BLVRB","ENSG00000090013","Nuclear receptors meta-pathway; NRF2 pathway; IL-10 anti-inflammatory signaling pathway","Cytoprotection by HMOX1; Heme degradation","Riboflavin metabolism; Porphyrin metabolism; Metabolic pathways",317,330.1,303.3,376,310.5,337.2,0.9283969913060467,-0.10718624759798662,0.299787814251219,0.5231860242929779,0.5011225120260153,0.3000560869221252,4671]
["High","P30047","GTP cyclohydrolase 1 feedback regulatory protein [OS=Homo sapiens]",19,1,1,1,84,9.7,6.54,2.46,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","GCHFR","ENSG00000137880","","Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","",15.1,13.9,18.2,15.5,8,15.2,1.2196382428940569,0.28645329321743096,0.36358655692694103,0.43939218254682033,0.565064457899195,0.24790200861732462,5024]
["High","P30153","serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [OS=Homo sapiens]",60,32,294,24,589,65.3,5.11,599.14,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP2R1A","ENSG00000105568","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Cyclin A/B1/B2 associated events during G2/M transition; Regulation of TP53 Degradation; Regulation of PLK1 Activity at G2/M Transition; Cyclin D associated events in G1; Spry regulation of FGF signaling; Negative regulation of MAPK pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; TGF-beta signaling pathway; Hippo signaling pathway; Tight junction; Dopaminergic synapse; Long-term depression; Chagas disease; Hepatitis C; Human papillomavirus infection",10179.6,10084,10397.3,10158.3,9932.1,10020.4,1.0182691924492207,0.026119006671669318,0.18207838205811552,0.7397416143928567,0.370612097786696,0.43108040823284727,3836]
["High","P30291-1","Wee1-like protein kinase [OS=Homo sapiens]",10,6,9,6,646,71.6,6.77,14.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","WEE1","ENSG00000166483","Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control","Factors involved in megakaryocyte development and platelet production; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin A:Cdk2-associated events at S phase entry; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Polo-like kinase mediated events; G2/M DNA replication checkpoint; Cyclin E associated events during G1/S transition","Cell cycle; Human immunodeficiency virus 1 infection",258.2,240.8,279.1,241.2,256.2,272,1.0113075123472837,0.016221750041032375,0.8481520096081792,0.07152630456197782,0.9193906554242209,0.03649991468003214,7203]
["High","P30566","adenylosuccinate lyase [OS=Homo sapiens]",32,16,44,16,484,54.9,7.11,87.55,"other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","ADSL","ENSG00000239900","Nucleotide metabolism","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of cofactors",2475.6,2539.7,2499.3,2867.9,2791.9,2843.1,0.8837690670241917,-0.1782586589630551,3.502783418635914E-4,3.4555867148088195,0.01486398528951588,1.8278647331597204,184]
["High","P30825","High affinity cationic amino acid transporter 1 [OS=Homo sapiens]",8,4,7,3,629,67.6,5.43,7.41,"transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC7A1","ENSG00000139514","VEGFA-VEGFR2 signaling pathway","Amino acid transport across the plasma membrane","MicroRNAs in cancer",404.6,400.3,359.4,425.9,405.8,422.5,0.9283208419709778,-0.10730458573872462,0.12868179387864986,0.8904828934790473,0.2990319781561006,0.5242823662102559,3360]
["High","P31040","Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [OS=Homo sapiens]",34,15,42,15,664,72.6,7.39,113.53,"other metabolic processes;developmental processes","other membranes;mitochondrion;nucleus","other molecular function","SDHA","ENSG00000073578","Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)","Respiratory electron transport; Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Oxidative phosphorylation; Metabolic pathways; Carbon metabolism; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",1615.8,1591.5,1614.4,1464.3,1460,1546.5,1.0784870716650266,0.10900888233374409,0.01610061544125259,1.793157522873028,0.0843715472250337,1.0738039866266667,1490]
["High","P31350-1","ribonucleoside-diphosphate reductase subunit M2 [OS=Homo sapiens]",40,12,34,11,389,44.8,5.38,64.89,"cell organization and biogenesis;other metabolic processes;developmental processes","cytosol","other molecular function","RRM2","ENSG00000171848","Fluoropyrimidine activity; Retinoblastoma gene in cancer; Hepatitis C and hepatocellular carcinoma; Pyrimidine metabolism; Nucleotide metabolism; Orexin receptor pathway","G1/S-Specific Transcription; Transcriptional Regulation by E2F6; Interconversion of nucleotide di- and triphosphates","Purine metabolism; Pyrimidine metabolism; Glutathione metabolism; Drug metabolism; Metabolic pathways; p53 signaling pathway",988.4,1121.9,1011.4,835.3,916.2,845.7,1.2019482519636535,0.26537478436648343,0.02252734553010167,1.6472899795831777,0.10346677288178462,0.9851990963028163,1700]
["High","P31689-1","DnaJ homolog subfamily A member 1 [OS=Homo sapiens]",65,20,120,20,397,44.8,7.08,309.2,"stress response;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","Dnaja1; DNAJA1; LOC109263810; LOC111146318; LOC112809310","ENSCAFG00000001474; ENSCAFG00000001818; ENSCATG00000033398; ENSCJAG00000008022; ENSCPOG00000000462; ENSECAG00000010324; ENSFCAG00000008729; ENSG00000086061; ENSGGOG00000007030; ENSLCNG00005016649; ENSMFAG00000032081; ENSMLEG00000042863; ENSMMUG00000007740; ENSMNEG00000030895; ENSNLEG00000005268; ENSOCUG00000004833; ENSPANG00000025299; ENSPPAG00000027533; ENSPPYG00000019141; ENSPTRG00000020852; ENSRROG00000029815; ENSSSCG00000011000; ENSSSCG00070018491; ENSSSUG00005020902; ENSSTOG00000005200","VEGFA-VEGFR2 signaling pathway; Exercise-induced circadian regulation","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","Protein processing in endoplasmic reticulum",4267.3,4256.2,4328.9,4434.8,4219.3,4385.9,0.9856134969325152,-0.020906082539326454,0.4162726026582697,0.3806221716399562,0.6142990893131298,0.21162012851337764,5291]
["High","P31947-1","14-3-3 protein sigma [OS=Homo sapiens]",38,8,125,4,248,27.8,4.74,270.24,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","enzyme regulator activity;other molecular function","SFN","ENSG00000175793; ENSGGOG00000011493; ENSNLEG00000018582; ENSPPAG00000013397; ENSPTRG00000030723","miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; DNA damage response; Calcium regulation in cardiac cells","TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","Cell cycle; p53 signaling pathway; Aldosterone-regulated sodium reabsorption",306.5,339.1,308.5,310.7,313.3,327,1.0032597266035752,4.6951431148878515E-3,0.933857938202083,0.029719185169739835,0.9658978383205542,0.01506880588258843,7549]
["High","P32322","Pyrroline-5-carboxylate reductase 1, mitochondrial [OS=Homo sapiens]",39,9,34,8,319,33.3,7.61,98.14,"other metabolic processes;stress response;other biological processes","mitochondrion","other molecular function","PYCR1","ENSG00000183010","Amino acid metabolism; Metabolic reprogramming in colon cancer","Glutamate and glutamine metabolism","Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids",1452.6,1537.8,1487.5,1488.3,1632.5,1603.7,0.9478040004233252,-0.07733934467997047,0.17907361657983403,0.7469683952667299,0.3674656500014045,0.43478325171468607,3805]
["High","P32519-1","ETS-related transcription factor Elf-1 [OS=Homo sapiens]",9,4,4,4,619,67.5,5.21,8.15,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ELF1","ENSG00000120690; ENSGGOG00000010760","","RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX1 regulates transcription of genes involved in BCR signaling","",114.9,117,123.6,86.8,91.6,97.1,1.2903811252268602,0.3677972410482577,0.002546658722376829,2.5940292509214413,0.031215559347438433,1.5056288785981564,637]
["High","P33897","ATP-binding cassette sub-family D member 1 [OS=Homo sapiens]",9,6,10,6,745,82.9,8.95,17.78,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ABCD1","ENSG00000101986","Vitamin D receptor pathway","Class I peroxisomal membrane protein import; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids; Linoleic acid (LA) metabolism; ABC transporters in lipid homeostasis; Defective ABCD1 causes ALD","ABC transporters; Peroxisome",510.8,457.5,495,445.7,452.7,420.7,1.1093169585323326,0.1496716370680448,0.06062002597047335,1.2173838819104807,0.18940422680170305,0.7226103333782954,2499]
["Low","P34741","syndecan-2 [OS=Homo sapiens]",5,1,1,1,201,22.1,4.86,0,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SDC2","ENSG00000169439","miRNA targets in ECM and membrane receptors","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cell surface interactions at the vascular wall; Syndecan interactions; EPHB-mediated forward signaling; A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Cell adhesion molecules; Malaria; Proteoglycans in cancer; Fluid shear stress and atherosclerosis",126.9,144.8,149.1,164.3,151.4,182.9,0.8439630966706779,-0.2447481781991983,0.08513576186325544,1.0698879732006292,0.23202095240080228,0.6344727948454025,2865]
["High","P34897-1","Serine hydroxymethyltransferase, mitochondrial [OS=Homo sapiens]",66,29,163,27,504,56,8.53,376.49,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","HEL-S-51e; SHMT2","ENSG00000182199","Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling","RHOG GTPase cycle; Metabolism of folate and pterines","Glycine, serine and threonine metabolism; Glyoxylate and dicarboxylate metabolism; One carbon pool by folate; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors; Antifolate resistance",6064.5,5967.4,6184.6,6007.4,6144,6190,0.9931902690089088,-0.009857968412242298,0.6437764951420479,0.191264883842478,0.7922154253852025,0.1011567056145662,6345]
["High","P35222","Catenin beta-1 [OS=Homo sapiens]",38,22,85,20,781,85.4,5.86,241.42,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CTNNB1","ENSG00000168036","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Heart development; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Gastric cancer network 2; Brain-derived neurotrophic factor (BDNF) signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Endoderm differentiation; Ectoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Focal adhesion; Ectoderm differentiation; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; OSX and miRNAs in tooth development; Wnt signaling pathway and pluripotency; PTF1A related regulatory pathway; Wnt signaling in kidney disease; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Genes controlling nephrogenesis; GDNF/RET signaling axis; Mammalian disorder of sexual development; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; 1q21.1 copy number variation syndrome; 7q11.23 copy number variation syndrome; Development of ureteric collection system; Malignant pleural mesothelioma; Alzheimer's disease; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response (only ATM dependent)","Deactivation of the beta-catenin transactivating complex; InlA-mediated entry of Listeria monocytogenes into host cells; RHO GTPases activate IQGAPs; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Myogenesis; Transcriptional Regulation by VENTX; Ca2+ pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; Apoptotic cleavage of cell adhesion  proteins; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production","Rap1 signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Leukocyte transendothelial migration; Melanogenesis; Thyroid hormone signaling pathway; Cushing syndrome; Alcoholic liver disease; Alzheimer disease; Pathways of neurodegeneration; Bacterial invasion of epithelial cells; Salmonella infection; Hepatitis C; Human cytomegalovirus infection; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Proteoglycans in cancer; Colorectal cancer; Endometrial cancer; Prostate cancer; Thyroid cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Arrhythmogenic right ventricular cardiomyopathy; Fluid shear stress and atherosclerosis",3523.9,3473.2,3370.2,3738.8,3778,3777.2,0.9179475827873207,-0.12351632056402774,0.002780509638788252,2.5558755950789727,0.032355021251354206,1.4900583105893295,671]
["High","P35249","replication factor C subunit 4 [OS=Homo sapiens]",61,19,43,19,363,39.7,8.02,86.27,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC4","ENSG00000163918","Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","Activation of ATR in response to replication stress; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",1739.8,1795,1750.4,2032.2,1909.8,1940.2,0.8985073611913911,-0.15439777155190945,7.963100924427648E-3,2.0989177799858814,0.05741079595376831,1.2410064319525664,1083]
["High","P35250-1","Replication factor C subunit 2 [OS=Homo sapiens]",57,17,59,17,354,39.1,6.44,147.72,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC2","ENSG00000049541","DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Dual Incision in GG-NER; Termination of translesion DNA synthesis; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",1999.3,2097.7,2046.7,1995.2,2178.1,2034.7,0.9896423969072163,-0.015020787279647629,0.748561874099537,0.12577229623020741,0.8615523456617313,0.06471833082022939,6784]
["High","P35555","Fibrillin-1 [OS=Homo sapiens]",3,8,10,5,2871,312,4.93,18.2,"","extracellular matrix","extracellular structural activity;other molecular function","","","","","",89.4,89.9,80.2,85.7,78.5,79.1,1.0665844636251542,0.09299821830681414,0.23908028556242447,0.6214562341077591,0.43615394151201176,0.36036019846229567,4280]
["High","P35610","sterol O-acyltransferase 1 [OS=Homo sapiens]",13,6,13,6,550,64.7,8.94,16.73,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","other molecular function","SOAT1","ENSG00000057252","Statin inhibition of cholesterol production; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","LDL clearance","Steroid biosynthesis; Cholesterol metabolism",354.7,366,378.5,295.8,287.5,312.2,1.2274706867671692,0.2956885719447766,2.4523790046663083E-3,2.6104124106155093,0.03093404728341605,1.5095632549769917,619]
["High","P35611-4","Isoform 4 of Alpha-adducin [OS=Homo sapiens]",43,22,80,2,662,73.3,6.16,141.49,"","","","ADD1","","","","",42.8,43.3,39.1,53,39.1,43,0.9267209474463359,-0.10979311239306637,0.48996131897352857,0.30983820490913516,0.677580229993856,0.16903927406140026,5646]
["High","P35813","Protein phosphatase 1A [OS=Homo sapiens]",36,12,35,11,382,42.4,5.36,68.31,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","PPM1A","ENSG00000100614","TGF-beta signaling pathway; MAPK signaling pathway","Downregulation of SMAD2/3:SMAD4 transcriptional activity; Energy dependent regulation of mTOR by LKB1-AMPK","MAPK signaling pathway",1339.7,1382,1340.4,1368,1452.5,1480.3,0.9444986979166665,-0.0823792871678019,0.09506326337012294,1.021987281148873,0.24824547170365213,0.6051186648146674,2990]
["High","P36405","ADP-ribosylation factor-like protein 3 [OS=Homo sapiens]",59,9,46,9,182,20.4,7.24,88.28,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","ARL3","ENSG00000138175","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","Trafficking of myristoylated proteins to the cilium","",1500.7,1437.8,1424.5,1294.9,1306.8,1231.3,1.138272893295069,0.1868464755759817,0.005992908444967089,2.2223623570689592,0.04869160160073156,1.3125459400788693,961]
["High","P36543","V-type proton ATPase subunit E 1 [OS=Homo sapiens]",54,13,38,13,226,26.1,8,79.95,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V1E1","ENSG00000131100","VEGFA-VEGFR2 signaling pathway; Proximal tubule transport","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",1989.5,1949.2,1925.8,1878.1,1810.7,1831.6,1.0623324396782843,0.08723530477153196,0.013603842033540585,1.8663384196943258,0.07680318047569407,1.114620795145001,1383]
["High","P36915-1","Guanine nucleotide-binding protein-like 1 [OS=Homo sapiens]",26,13,33,13,607,68.6,5.8,68.26,"stress response;signal transduction;other biological processes","non-structural extracellular","other molecular function","GNL1","ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986","","","",921.1,937.6,960.4,870.1,877.6,903.9,{"$f":"AVERAGE(T1858:V1858)/AVERAGE(W1858:Y1858)","v":1.0631694071503996},{"$f":"LOG(Z1858,2)","v":0.08837149657077044},{"$f":"TTEST(T1858:V1858,W1858:Y1858,2,2)","v":0.021897300275344478},{"$f":"-LOG10(AB1858)","v":1.6596094261550876},{"$f":"AB1858*7808/AF1858","v":0.10128798610775455},{"$f":"-LOG10(AD1858)","v":0.9944420637860883},1688]
["High","P36955","Pigment epithelium-derived factor [OS=Homo sapiens]",5,2,4,2,418,46.3,6.38,8.18,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other cell component","enzyme regulator activity","SERPINF1","ENSG00000132386","lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Type I collagen synthesis in the context of osteogenesis imperfecta; GPR143 in melanocytes and retinal pigment epithelium cells; Malignant pleural mesothelioma","","Wnt signaling pathway",74.3,96.3,85.4,72.6,92.8,85.1,1.0219560878243514,0.031333206804791784,0.8426709197333939,0.0743419931645964,0.9167583309569931,0.037745134738277036,7177]
["High","P37837","Transaldolase [OS=Homo sapiens]",44,17,161,17,337,37.5,6.81,329.5,"other metabolic processes","cytosol;other cell component","other molecular function","TALDO1","ENSG00000177156","Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of  Fru(6)P, E4P to SH7P, GA3P","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",9181.6,9275,9072.9,9028.6,9062,8986.8,1.0166965809124953,0.023889190969971174,0.07289868450810633,1.137280308664538,0.21151725330334234,0.6746542017696571,2691]
["High","P38159-2","Isoform 2 of RNA-binding motif protein, X chromosome [OS=Homo sapiens]",67,34,266,11,378,40.8,10.04,391.98,"","","","RBMX","","","","",13090,12322.1,13686.9,16167.5,15243.1,16476.9,0.8164761158966327,-0.29251741115975,0.005660622159239512,2.247135832862051,0.046919466899513915,1.3286469309962927,942]
["High","P39023","60S ribosomal protein L3 [OS=Homo sapiens]",47,22,295,22,403,46.1,10.18,487.69,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","other molecular function","RPL3","ENSG00000100316","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",12272.1,12363.4,11892.5,11173.9,12157.3,11959.9,1.0350484966464635,0.04969836601660071,0.28357503885779023,0.5473319997351491,0.4839680663172953,0.31518329347898083,4575]
["High","P40123","Adenylyl cyclase-associated protein 2 [OS=Homo sapiens]",32,14,33,13,477,52.8,6.37,71.97,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","cytoskeletal activity;other molecular function","CAP2","ENSG00000112186","Ectoderm differentiation; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway","Role of ABL in ROBO-SLIT signaling","",1290.7,1336.1,1355.1,1442.4,1503.2,1469.9,0.9018004755973276,-0.14911982405395013,0.005098824876856422,2.292529903961332,0.04453201861129188,1.3513276180986142,894]
["High","P40429","60S ribosomal protein L13a [OS=Homo sapiens]",42,12,97,12,203,23.6,10.93,170.49,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","RPL13A","ENSG00000142541","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",5667.7,5853.9,5418.2,4908,5689,5216,1.0712578258394991,0.09930574366902059,0.22183968343069294,0.6539607631759633,0.41657629827485576,0.38030544351277834,4158]
["High","P40937-1","Replication factor C subunit 5 [OS=Homo sapiens]",68,20,58,20,340,38.5,7.2,116.44,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC5","ENSG00000111445","Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","HDR through Homologous Recombination (HRR); Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Termination of translesion DNA synthesis; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",2768.5,2913.1,2585.8,2662.9,3022,2883.7,0.9648483999719912,-0.05162581550158206,0.5159730810640297,0.28737295544702396,0.6982179925386385,0.15600896394411998,5770]
["Medium","P41217","OX-2 membrane glycoprotein [OS=Homo sapiens]",4,1,1,1,278,31.2,8.51,2.55,"cell adhesion;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CD200","ENSG00000091972","Vitamin D receptor pathway","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","",140.2,143,143.7,151.9,170.2,138.5,0.926834563612679,-0.10961624854520716,0.29135143869553026,0.5355828330192155,0.4928232307917461,0.3073088285082552,4616]
["High","P41225","Transcription factor SOX-3 [OS=Homo sapiens]",29,7,13,7,446,45.2,9.77,44.52,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SOX3","ENSG00000134595","","Deactivation of the beta-catenin transactivating complex","",411.2,494.6,444.5,228.8,249,232.7,1.9004926108374383,0.9263734159765649,1.0385664069110876E-3,2.9835657290441517,0.021452715622121088,1.6685177242227416,378]
["High","P41273","Tumor necrosis factor ligand superfamily member 9 [OS=Homo sapiens]",11,2,2,2,254,26.6,7.02,0,"cell-cell signaling;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding","TNFSF9","ENSG00000125657","Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling","TNFs bind their physiological receptors","Cytokine-cytokine receptor interaction",19.4,22.4,14.9,19.7,15.6,18.9,{"$f":"AVERAGE(T1922:V1922)/AVERAGE(W1922:Y1922)","v":1.0461254612546125},{"$f":"LOG(Z1922,2)","v":0.06505588358835718},{"$f":"TTEST(T1922:V1922,W1922:Y1922,2,2)","v":0.7570016958211297},{"$f":"-LOG10(AB1922)","v":0.12090314760041071},{"$f":"AB1922*7808/AF1922","v":0.8656516170139692},{"$f":"-LOG10(AD1922)","v":0.06265685538447127},6828]
["High","P42167","Lamina-associated polypeptide 2, isoforms beta/gamma [OS=Homo sapiens]",52,19,144,6,454,50.6,9.38,338.34,"","other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","TMPO","ENSG00000120802","Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RHOC GTPase cycle; RHOJ GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle","",2743.2,2765.5,2971.1,3044.2,2987.5,3001.7,0.9387163194367569,-0.09123885434115422,0.06845704339704038,1.1645818616117902,0.20354630420567071,0.6913367787066154,2626]
["High","P42285","Superkiller viralicidic activity 2-like 2 [OS=Homo sapiens]",36,35,115,34,1042,117.7,6.52,206.2,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus","other molecular function","MTREX","ENSG00000039123","","mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol","RNA degradation",4248.2,4388,4316.7,4808.7,5147.4,5068.4,0.8621185397184601,-0.21404184401128012,3.2853514131611426E-3,2.483418169898953,0.034900712699268296,1.4571657043245128,735]
["High","P42575-1","caspase-2 [OS=Homo sapiens]",3,2,2,2,452,50.7,6.81,6.43,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","CASP2","ENSG00000106144; ENSPPAG00000028627; ENSPTRG00000019805; ENSPTRG00000047033","Apoptosis modulation and signaling; Parkinson's disease pathway; Apoptosis; Apoptosis modulation by HSP70; Acute viral myocarditis; Apoptosis modulation by HSP70","TP53 Regulates Transcription of Caspase Activators and Caspases; NOD1/2 Signaling Pathway; NADE modulates death signalling","Apoptosis",90.6,97.6,92.6,102.3,105.8,102.7,0.9034749034749032,-0.14644356810314976,0.013240085101045606,1.87810922344649,0.07567978365224311,1.1210201181333685,1366]
["High","P42695","condensin-2 complex subunit D3 [OS=Homo sapiens]",14,15,27,15,1498,168.8,7.5,41.1,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","other molecular function","NCAPD3","ENSG00000151503","","Condensation of Prophase Chromosomes","",1036.9,1115.8,1056.7,1131.8,1106.4,1126.5,0.9538443249026659,-0.06817426892649765,0.10644865761489551,0.9728598109200635,0.2658832753221702,0.5753089799445962,3126]
["High","P42858","huntingtin [OS=Homo sapiens]",13,33,62,33,3142,347.4,6.2,114.75,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","HTT","ENSG00000197386","Mesodermal commitment pathway; Mesodermal commitment pathway; ERK pathway in Huntington's disease; Rett syndrome causing genes","Regulation of MECP2 expression and activity","Huntington disease; Pathways of neurodegeneration",2470.5,2440.3,2427,2503.4,2535.7,2555.3,0.9662119456441589,-0.04958840542201637,0.012585762585385551,1.9001204649315708,0.073445167613371,1.1340367737047397,1338]
["High","P43155","Carnitine O-acetyltransferase [OS=Homo sapiens]",8,4,5,4,626,70.8,8.44,10.23,"other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","CRAT","ENSG00000095321","Fatty acid beta-oxidation","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","",232.3,241.6,215.3,227.3,234.4,238.1,0.9848528150900258,-0.02201996301490123,0.6931366161357625,0.1591811581927667,0.8255049876125737,0.0832802984325928,6556]
["High","P43304","Glycerol-3-phosphate dehydrogenase, mitochondrial [OS=Homo sapiens]",44,25,80,25,727,80.8,7.69,158.64,"other metabolic processes","other membranes;mitochondrion;other cell component","other molecular function","GPD2","ENSG00000115159","Fatty acid beta-oxidation","Triglyceride catabolism; Synthesis of PA","Glycerophospholipid metabolism",3222.3,3480,3171.9,3310.2,3733,3494.6,0.9370267038660821,-0.09383793175615121,0.22717182791721827,0.6436455274447687,0.4230282929591319,0.37363058518970155,4193]
["High","P45880","Voltage-dependent anion-selective channel protein 2 [OS=Homo sapiens]",68,16,150,15,294,31.5,7.56,373.23,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","VDAC2","ENSG00000165637","Alzheimer's disease and miRNA effects; Ferroptosis; Alzheimer's disease","Ub-specific processing proteases; Mitochondrial calcium ion transport","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy",6586.9,6986.3,6316.1,5318.8,6225.2,5881.1,1.1414166920132456,0.1908255661720753,0.06653879668209578,1.1769250573753893,0.1999749516912255,0.699024399453763,2598]
["High","P45984-1","Mitogen-activated protein kinase 9 [OS=Homo sapiens]",10,5,14,4,424,48.1,5.63,22.71,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","MAPK9","ENSG00000050748; ENSGGOG00000016519; ENSOCUG00000015542; ENSPPAG00000038007; ENSPTRG00000017633","IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Wnt signaling pathway and pluripotency; Splicing factor NOVA regulated synaptic proteins; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; CCL18 signaling pathway; Familial partial lipodystrophy (FPLD); Alzheimer's disease; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway; MAPK signaling pathway; Wnt signaling pathway","Oxidative Stress Induced Senescence; FCERI mediated MAPK activation; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors","Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; cAMP signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Mitophagy; Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Apoptosis; Necroptosis; Wnt signaling pathway; Osteoclast differentiation; Focal adhesion; Tight junction; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; Insulin signaling pathway; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Adipocytokine signaling pathway; Relaxin signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Measles; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Choline metabolism in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",391.7,399.4,373.1,360.7,346.6,333.8,1.1182403227355682,0.1612302732972928,0.020370235815098826,1.6910039433806225,0.09674622946733066,1.0143659519260189,1644]
["High","P46087-2","Isoform 2 of Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase [OS=Homo sapiens]",44,30,141,30,808,88.9,9.23,295.98,"","","","NOP2","","","","",5852.2,5493.2,5810.5,5515.3,5272.3,5603.1,1.0466850104022405,0.06582734264839638,0.16527246003179294,0.7817995085137102,0.349619985892235,0.4564037490507319,3691]
["High","P46736","Lys-63-specific deubiquitinase BRCC36 [OS=Homo sapiens]",27,8,23,8,316,36,5.92,53.29,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","BRCC3","ENSG00000185515","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","Homologous recombination; NOD-like receptor signaling pathway",705.3,793.8,702.2,743,742.3,745.2,0.9869087648509304,-0.019011374522779474,0.7621837826289151,0.11794029616960153,0.8685246606489447,0.061217845804438974,6852]
["High","P46777","60S ribosomal protein L5 [OS=Homo sapiens]",64,20,329,20,297,34.3,9.72,573.24,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL5","ENSG00000122406","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",15965.7,16030.1,16443.8,15888.1,16224.6,16035.1,1.0060605053605771,0.008717072696846673,0.6151013465766262,0.2110533222200206,0.7727612733821877,0.11195465053904884,6215]
["High","P46934-4","Isoform 4 of E3 ubiquitin-protein ligase NEDD4 [OS=Homo sapiens]",6,5,7,3,900,104.2,5.97,7.19,"","","","NEDD4","","","","",10.7,15.9,15.1,16.3,8.2,11.8,1.1487603305785126,0.20007783544891314,0.5615149324273006,0.250638690008849,0.7336527095703418,0.13450947415755596,5976]
["High","P47895","Aldehyde dehydrogenase family 1 member A3 [OS=Homo sapiens]",20,11,19,8,512,56.1,7.25,35.56,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","ALDH1A3","ENSG00000184254","Ethanol effects on histone modifications; Vitamin A and carotenoid metabolism","RA biosynthesis pathway","Retinol metabolism; Metabolic pathways",549.4,573.5,547.9,608.3,593,576.1,0.9400247552604929,-0.08922934467019106,0.0463221143376486,1.3342116257871606,0.1606052703145472,0.7942402073078338,2252]
["High","P47897","glutamine--tRNA ligase [OS=Homo sapiens]",51,38,153,37,775,87.7,7.15,333.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;mitochondrion;other cell component","enzyme regulator activity;other molecular function","QARS1","ENSG00000172053","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis; Metabolic pathways",6555.5,6923.5,6759.1,5576.2,5933.5,5954,1.1588666777372492,0.21271460048502772,0.004697817321858117,2.3281038750959793,0.042552851101007164,1.3710713362620566,862]
["High","P48200","iron-responsive element-binding protein 2 [OS=Homo sapiens]",4,4,4,4,963,105,7.05,6.34,"","","","","","","","",166.1,164.4,154.5,130.6,118.2,135.5,1.2620348685922456,0.33575177089904956,5.944668407386086E-3,2.225872365243571,0.04855227084191481,1.3137904528610356,956]
["High","P48444","Coatomer subunit delta [OS=Homo sapiens]",49,22,104,22,511,57.2,6.21,174.94,"transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","","ARCN1","ENSG00000095139","miR-517 relationship with ARCN1 and USP1","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",4961.6,5251.9,4678.1,4587.6,5061.1,4815.7,1.0295345814551589,0.04199229005366301,0.5435829973425783,0.26473413596415474,0.7192503038893157,0.1431199459445185,5901]
["High","P48553","Trafficking protein particle complex subunit 10 [OS=Homo sapiens]",3,3,4,3,1259,142.1,6.04,10.65,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC10","ENSG00000160218","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",116.6,110.4,112,111,125,114,0.9685714285714285,-0.04606964869598498,0.47393793214575686,0.32427853067108814,0.6638872217786275,0.17790569038973816,5574]
["High","P48681","Nestin [OS=Homo sapiens]",55,73,259,73,1621,177.3,4.36,559.8,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;other molecular function","NES","ENSG00000132688","","","",11353.4,9520.3,11110.8,12483.3,9682.2,10028.2,0.9935018342097987,-0.00940546389662653,0.9503573874725986,0.022113045006403105,0.9757252441007298,0.010672458736784891,7605]
["High","P49023","Paxillin [OS=Homo sapiens]",32,12,31,12,591,64.5,6.19,52.07,"cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PXN","ENSG00000089159","Integrin-mediated cell adhesion; Prolactin signaling pathway; Oncostatin M signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; 3q29 copy number variation syndrome; Regulation of actin cytoskeleton","VEGFA-VEGFR2 Pathway; GAB1 signalosome; Smooth Muscle Contraction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","Chemokine signaling pathway; VEGF signaling pathway; Focal adhesion; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Human papillomavirus infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis; Proteoglycans in cancer",1137.4,1069.5,1207.1,1176.3,1054.9,1102.7,1.024025915594349,0.034252226887074765,0.6417942618125032,0.192604170185835,0.7911477101724069,0.1017424245630927,6334]
["High","P49069","calcium signal-modulating cyclophilin ligand [OS=Homo sapiens]",22,5,9,5,296,32.9,8.05,27.55,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","CAMLG","ENSG00000164615","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",331.3,304.9,337.5,303.7,297.4,302,1.0781751743992913,0.10859159618474118,0.08168314903051331,1.0878675277745606,0.22616383958519432,0.6455768314352863,2820]
["High","P49327","Fatty acid synthase [OS=Homo sapiens]",60,115,750,114,2511,273.3,6.44,1825.21,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","FASN","ENSG00000169710","AMP-activated protein kinase (AMPK) signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway","ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism","Fatty acid biosynthesis; Metabolic pathways; Fatty acid metabolism; AMPK signaling pathway; Insulin signaling pathway; Alcoholic liver disease",32212.6,33105,31472.7,28370.4,30789.1,29945.9,1.0862450536106678,0.11934960751368462,0.03961624447377097,1.4021266969353603,0.14618319321890536,0.835102555639873,2116]
["High","P49406","39S ribosomal protein L19, mitochondrial [OS=Homo sapiens]",35,10,18,9,292,33.5,9.5,36.57,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPL19","ENSG00000115364","Cytoplasmic ribosomal proteins","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",913.2,978.4,937.2,861.4,1063.3,958.5,0.9811320754716982,-0.02748073642210685,0.7821889780071617,0.10668830807756613,0.8800189539308241,0.055507973873785595,6940]
["High","P49441","Inositol polyphosphate 1-phosphatase [OS=Homo sapiens]",14,3,4,3,399,44,5.26,7.09,"other metabolic processes;signal transduction","cytosol","other molecular function","INPP1","ENSG00000151689","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",33.8,38.3,31,31.9,36.1,34.2,1.0088062622309197,0.012649136430487,0.9083963360427871,0.04172462614715991,0.9514096031954503,0.02163246927753786,7455]
["High","P49591","Serine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",47,24,116,24,514,58.7,6.43,211.34,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SARS1","ENSG00000031698","VEGFA-VEGFR2 signaling pathway","Cytosolic tRNA aminoacylation; Selenocysteine synthesis","Aminoacyl-tRNA biosynthesis",4045.6,4092.4,4059.7,4079.7,4143.2,4083.8,0.99114303590727,-0.012834821226107787,0.21617724573799585,0.6651900206994965,0.41068416903218286,0.3864920379169303,4110]
["High","P49736","DNA replication licensing factor mcm2 [OS=Homo sapiens]",58,46,213,46,904,101.8,5.52,476.82,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM2","ENSG00000073111","Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","DNA replication; Cell cycle",7637.5,7770.6,7641,7822.6,8441.5,8269.4,0.9394949762569548,-0.09004264771627936,0.059406061270838265,1.226169241177366,0.1874868740512147,0.7270291318118324,2474]
["High","P49756-1","RNA-binding protein 25 [OS=Homo sapiens]",39,36,103,36,843,100.1,6.32,213.46,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RBM25","ENSG00000119707; ENSGGOG00000002415; ENSPPAG00000039402; ENSPTRG00000006509","","","Spliceosome",5170.1,4716.5,5164.7,5236.7,5087.4,5218.9,0.9683651804670914,-0.04637688964239075,0.3568330035519547,0.4475349844594972,0.5584590282087918,0.2530086837400435,4989]
["High","P49773","Histidine triad nucleotide-binding protein 1 [OS=Homo sapiens]",40,5,14,5,126,13.8,6.95,36.19,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","HINT1","ENSG00000169567","","","",1017.5,1020.8,998.9,1045.1,977,953.3,1.020770316596088,0.02965828209721422,0.5076385774079042,0.2944453816152287,0.6917350806982402,0.16006019892398327,5730]
["High","P49840","Glycogen synthase kinase-3 alpha [OS=Homo sapiens]",30,8,17,6,483,50.9,8.75,34.2,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","GSK3A","ENSG00000105723","IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation","XBP1(S) activates chaperone genes; Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein","Chemokine signaling pathway; Dopaminergic synapse; Non-alcoholic fatty liver disease; Shigellosis",336.7,322.4,271.7,281.8,313.8,288.2,1.0531794523647884,0.07475127964834312,0.5159111363944762,0.28742509739812194,0.6983762401123561,0.15591054445085914,5768]
["High","P49915","GMP synthase [glutamine-hydrolyzing] [OS=Homo sapiens]",73,43,195,43,693,76.7,6.87,428.98,"other metabolic processes","cytosol","other molecular function","GMPS","ENSG00000163655","","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Drug metabolism; Metabolic pathways",8211.9,8228.2,8181.9,8352.5,9077.2,8701.7,0.9422380737350468,-0.0858364656209144,0.07440134773231372,1.1284191974190996,0.21357563349040642,0.6704482967946629,2720]
["High","P50148","Guanine nucleotide-binding protein G(Q) subunit alpha [OS=Homo sapiens]",12,5,10,4,359,42.1,5.68,22.41,"cell-cell signaling;stress response;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","GNAQ","ENSG00000156052","Thyroid stimulating hormone (TSH) signaling pathway; Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Circadian rhythm genes; Cell-type dependent selectivity of CCK2R signaling; Hippo signaling regulation pathways; Gastrin signaling pathway; PKC-gamma calcium signaling pathway in ataxia; GPR143 in melanocytes and retinal pigment epithelium cells; Airway smooth muscle cell contraction; Prostaglandin and leukotriene metabolism in senescence ; Alzheimer's disease; Calcium regulation in cardiac cells; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 2 and STAT3 signaling","G alpha (q) signalling events; Thrombin signalling through proteinase activated receptors (PARs); G-protein activation; ADP signalling through P2Y purinoceptor 1; Thromboxane signalling through TP receptor; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Apelin signaling pathway; Gap junction; Platelet activation; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Yersinia infection; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",293.4,332.2,285.2,277.3,326,283.7,1.0268320180383312,0.03820018694819596,0.7255297319129135,0.1393447856505891,0.8470299262523966,0.0721012454229137,6688]
["High","P50395-1","Rab GDP dissociation inhibitor beta [OS=Homo sapiens]",74,32,218,24,445,50.6,6.47,449.1,"transport;signal transduction","non-structural extracellular;other membranes;cytosol;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","GDI2","ENSG00000057608; ENSNLEG00000035201","","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs","",9746.5,10356.5,9886,9106.4,10169.9,9595.9,1.0386808071432037,0.0547523734902143,0.35769684469648966,0.4464848908181739,0.5592504932699621,0.2523936241748675,4994]
["High","P50479-1","PDZ and LIM domain protein 4 [OS=Homo sapiens]",3,1,1,1,330,35.4,7.91,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","PDLIM4","ENSG00000131435; ENSPTRG00000017214","","","",125.1,107.4,98,101.4,102.6,110.7,1.0502065459167462,0.07067309309663042,0.5675088213594329,0.24602738340717556,0.7369214829826131,0.1325787825940393,6013]
["High","P50552","Vasodilator-stimulated phosphoprotein [OS=Homo sapiens]",57,16,65,16,380,39.8,8.94,143.39,"cell organization and biogenesis;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","VASP","ENSG00000125753","Integrin-mediated cell adhesion; Focal adhesion","Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions","Rap1 signaling pathway; cGMP-PKG signaling pathway; Focal adhesion; Tight junction; Platelet activation; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration",2306.9,2109.3,2333.3,2182.5,2102.9,2065.9,1.0626958260513597,0.08772871535992491,0.1665667938998564,0.7784115735381255,0.35121618330274884,0.4544254809289327,3703]
["High","P50851-1","Lipopolysaccharide-responsive and beige-like anchor protein [OS=Homo sapiens]",19,35,60,1,2863,318.9,5.6,118.25,"other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","LRBA","ENSG00000198589","","","",2143,2284.5,2155.5,2142.3,2141.1,2116.9,1.0285455369279568,0.040605667898663746,0.2559305037009639,0.59187794858135,0.4543668424049854,0.34259336894748615,4398]
["High","P50991","T-complex protein 1 subunit delta [OS=Homo sapiens]",71,31,355,31,539,57.9,7.83,816.82,"transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CCT4","ENSG00000115484","16p11.2 proximal deletion syndrome","Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; Folding of actin by CCT/TriC","",12789.2,13603.8,12362.8,12586.8,13789.3,13242.7,0.9782174119357476,-0.03177295050424884,0.5982366291517495,0.22312699927617366,0.7582843507170227,0.12016790678196372,6160]
["High","P51148","Ras-related protein Rab-5C [OS=Homo sapiens]",74,11,46,9,216,23.5,8.41,119.88,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","RAB5C","ENSG00000108774","Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells","Clathrin-mediated endocytosis; Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Golgi Associated Vesicle Biogenesis; TBC/RABGAPs","Ras signaling pathway; Endocytosis; Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection; Amoebiasis; Tuberculosis",1407.6,1492.3,1420.8,1207,1423,1317.7,1.0944853965600223,0.13025270513467482,0.14008833222062775,0.8535980350440904,0.31503735540860067,0.5016379468899091,3472]
["High","P51511","Matrix metalloproteinase-15 [OS=Homo sapiens]",7,3,4,3,669,75.8,7.46,11.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes","enzyme regulator activity;other molecular function","MMP15","ENSG00000102996","Matrix metalloproteinases; Epithelial to mesenchymal transition in colorectal cancer","Collagen degradation; Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action",170.8,164,194.1,216.2,221.6,220.2,0.8037993920972644,-0.31509260858126614,0.009668456466454483,2.01464285390127,0.06397568482209881,1.1939850565487602,1180]
["Medium","P51512-1","Matrix metalloproteinase-16 [OS=Homo sapiens]",1,1,1,1,607,69.5,8.54,2,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","MMP16","ENSCANG00000029811; ENSCATG00000039014; ENSCSAG00000012941; ENSG00000156103; ENSGGOG00000027756; ENSMFAG00000040046; ENSMMUG00000013193; ENSMNEG00000003965; ENSPANG00000010068; ENSRBIG00000031261; ENSRROG00000034264","Matrix metalloproteinases","Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action; MicroRNAs in cancer",84.6,75.4,80.2,80,68,78.3,1.0614228899690674,0.08599956643874139,0.3703159590258121,0.43142757132215276,0.572559803578919,0.24217914478217872,5050]
["High","P51648","Fatty aldehyde dehydrogenase [OS=Homo sapiens]",24,11,36,11,485,54.8,7.88,85.84,"other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ALDH3A2","ENSG00000072210","Fragile X syndrome; Tryptophan metabolism; Fluoroacetic acid toxicity","RND2 GTPase cycle; RND1 GTPase cycle","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease",1446.8,1610.2,1502.8,1524.5,1652.8,1604,0.9536736870725535,-0.06843238271667146,0.291375664934758,0.5355467223871395,0.49265075613048737,0.3074608463096617,4618]
["High","P51688","N-sulphoglucosamine sulphohydrolase [OS=Homo sapiens]",12,4,8,4,502,56.7,6.95,19.39,"protein metabolism;other metabolic processes","other cytoplasmic organelle","other molecular function","SGSH","ENSG00000181523","Glycosaminoglycan degradation","HS-GAG degradation; MPS IIIA - Sanfilippo syndrome A","Glycosaminoglycan degradation; Metabolic pathways; Lysosome",178.4,193.2,190.5,157.6,160,161.1,1.1742218508460411,0.231705008855152,0.003985091666194984,2.399561684389627,0.03850940065550797,1.414433240505578,808]
["High","P51797-1","Chloride transport protein 6 [OS=Homo sapiens]",4,2,2,2,869,97.2,6.81,5.36,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","CLCN6","ENSG00000011021","","Signaling by BRAF and RAF1 fusions; Stimuli-sensing channels","",26.1,32.5,28.3,31.1,30.3,24.9,1.006952491309386,0.009995617635445247,0.9446046494808036,0.02474992109375969,0.9723761507114191,0.012165701557873597,7585]
["Medium","P51825","AF4/FMR2 family member 1 [OS=Homo sapiens]",1,1,1,1,1210,131.3,9.2,2.1,"other biological processes","nucleus","","AFF1","ENSG00000172493","","","Transcriptional misregulation in cancer",57.3,66.3,76.1,66.1,77.4,89.2,0.858186506231199,-0.22063687796137604,0.2699944113029903,0.5686452253424654,0.4696182587332921,0.32825502608548285,4489]
["High","P51948-1","CDK-activating kinase assembly factor MAT1 [OS=Homo sapiens]",28,6,12,6,309,35.8,6.09,32.73,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","enzyme regulator activity;kinase activity;other molecular function","MNAT1","ENSCANG00000033478; ENSCATG00000030975; ENSCSAG00000014164; ENSG00000020426; ENSMFAG00000000901; ENSMMUG00000001642; ENSNLEG00000013781; ENSPPAG00000033622; ENSPTRG00000006412; ENSRROG00000035712","Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; Eukaryotic transcription initiation; G1 to S cell cycle control","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin D associated events in G1; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Basal transcription factors; Nucleotide excision repair",443.1,477.6,450.8,419.6,413.7,413.9,1.0996632456703017,0.13706178903785524,0.017591300512309775,1.7547020522741226,0.08936426441126527,1.0488361151152323,1537]
["High","P51991-1","Heterogeneous nuclear ribonucleoprotein A3 [OS=Homo sapiens]",52,24,241,22,378,39.6,9.01,505.27,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","transporter activity;nucleic acid binding activity","HNRNPA3; HNRPA3","ENSG00000170144; ENSGGOG00000006130; ENSHGLG00000005451; ENSPPAG00000023768; ENSPTRG00000012676; ENSSTOG00000025125","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Spliceosome; Amyotrophic lateral sclerosis",10003.5,10315.2,11142.8,11188.2,11300.1,11533.5,0.924745310359828,-0.11287201582657529,0.07394062211066842,1.1311168997448726,0.21311494183835325,0.6713861001194056,2709]
["High","P52306-1","Rap1 GTPase-GDP dissociation stimulator 1 [OS=Homo sapiens]",27,11,23,11,607,66.3,5.31,47.1,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;ER/Golgi","enzyme regulator activity","RAP1GDS1","ENSG00000138698","","RHOT2 GTPase cycle; RHOT1 GTPase cycle","",1003.2,1081.6,999.3,1022.7,990.1,1008.9,1.0206506271304234,0.0294891103256701,0.50485690639072,0.29683169825964245,0.6886657451255663,0.1619915186887458,5724]
["High","P52597","Heterogeneous nuclear ribonucleoprotein F [OS=Homo sapiens]",66,18,246,16,415,45.6,5.58,405.27,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPF","ENSG00000169813","MECP2 and associated Rett syndrome","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",5851.2,5720.4,6117.5,5880.9,5800.1,5808.3,1.0114241278953415,0.01638810001026492,0.6073808902321518,0.21653887622625492,0.7662675700327422,0.11561955426043355,6189]
["High","P52739","Zinc finger protein 131 [OS=Homo sapiens]",23,9,13,9,623,71.4,5.19,20.41,"other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","ZNF131","ENSG00000172262","","SUMOylation of transcription cofactors","",310,276.7,288.8,258,288.5,255.2,1.0920543844330797,0.1270447044246252,0.16359653376753686,0.7862259022635909,0.3485298050905669,0.4577600765821022,3665]
["High","P52789","Hexokinase-2 [OS=Homo sapiens]",46,37,122,34,917,102.3,6.05,291.02,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component","kinase activity;other molecular function","HK2","ENSG00000159399","Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis","Glycolysis","Glycolysis / Gluconeogenesis; Fructose and mannose metabolism; Galactose metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Neomycin, kanamycin and gentamicin biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of nucleotide sugars; HIF-1 signaling pathway; Insulin signaling pathway; Type II diabetes mellitus; Carbohydrate digestion and absorption; Shigellosis; Central carbon metabolism in cancer",4571.1,4496.2,4530.9,4419.6,4448.5,4637.6,{"$f":"AVERAGE(T2242:V2242)/AVERAGE(W2242:Y2242)","v":1.0068489600687114},{"$f":"LOG(Z2242,2)","v":0.009847277283890133},{"$f":"TTEST(T2242:V2242,W2242:Y2242,2,2)","v":0.6893455547453722},{"$f":"-LOG10(AB2242)","v":0.1615630206196736},{"$f":"AB2242*7808/AF2242","v":0.823250243415703},{"$f":"-LOG10(AD2242)","v":0.08446813220538837},6538]
["High","P52907","F-actin-capping protein subunit alpha-1 [OS=Homo sapiens]",67,13,143,11,286,32.9,5.69,385.37,"cell organization and biogenesis","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity","CAPZA1","ENSG00000116489","","MHC class II antigen presentation; Advanced glycosylation endproduct receptor signaling; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production","Endocytosis",5028,4929.8,5080.3,4934.7,4950,5110.2,1.0028809795330411,0.004150399144306614,0.8499787010609621,0.0705919567887519,0.9206039253549718,0.03592717765367903,7209]
["High","P53367","Arfaptin-1 [OS=Homo sapiens]",54,16,45,1,373,41.7,6.7,91.35,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","ARFIP1","ENSG00000164144","","","",1570.2,1632.2,1578.3,1469.7,1349.3,1384.4,1.137341199980968,0.18566512465803764,0.00911812850181782,2.04009429157723,0.06174704886573594,1.2093837942132937,1153]
["High","P53611","Geranylgeranyl transferase type-2 subunit beta [OS=Homo sapiens]",20,7,20,7,331,36.9,5.03,29.64,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RABGGTB","ENSG00000137955","","RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain","",599.1,641.8,604.7,506.2,584.6,537.4,1.1335216803832455,0.1808119851521605,0.05183725236606794,1.2853580263095192,0.17296806259583694,0.7620340790610267,2340]
["High","P53667-1","LIM domain kinase 1 [OS=Homo sapiens]",8,3,6,3,647,72.5,6.98,12.9,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","LIMK1","ENSG00000106683; ENSPTRG00000019286; ENSPTRG00000045946","Microtubule cytoskeleton regulation; VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; G13 signaling pathway","Regulation of actin dynamics for phagocytic cup formation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Axon guidance; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Human immunodeficiency virus 1 infection",171.1,210.3,163.4,197.9,209.7,212.2,0.8789932236205228,-0.18607605157414447,0.17483078160228332,0.7573821008600665,0.36218592272502736,0.4410684336510361,3769]
["High","P53778","Mitogen-activated protein kinase 12 [OS=Homo sapiens]",10,3,3,3,367,41.9,6.39,4.87,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","MAPK12","ENSG00000188130","Integrin-mediated cell adhesion; Parkinson's disease pathway; S1P receptor signal transduction; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway","p38MAPK events; Negative regulation of MAPK pathway; VEGFA-VEGFR2 Pathway; Myogenesis; NOD1/2 Signaling Pathway; DSCAM interactions; Activation of PPARGC1A (PGC-1alpha) by phosphorylation","Endocrine resistance; MAPK signaling pathway; Rap1 signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; VEGF signaling pathway; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Leukocyte transendothelial migration; Thermogenesis; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Relaxin signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Proteoglycans in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",58,57.5,62.7,65.3,61.3,65.2,0.9290928050052137,-0.10610538349620888,0.09882882566971227,1.0051163650944028,0.25450378325498463,0.5943057573957833,3032]
["High","P53985","Monocarboxylate transporter 1 [OS=Homo sapiens]",15,13,93,13,500,53.9,8.66,223.41,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;other molecular function","SLC16A1","ENSG00000155380; ENSG00000281917","Photodynamic therapy-induced HIF-1 survival signaling; Fragile X syndrome","Basigin interactions; Pyruvate metabolism; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)","",6718.1,6829.7,6875,6582.2,6018.1,6510.3,1.0686634642554393,0.09580760152453101,0.07547181126845147,1.1222152271325658,0.21577587051778435,0.6659971226136637,2731]
["High","P54252","Ataxin-3 [OS=Homo sapiens]",12,3,5,3,364,41.8,4.91,7.43,"","","","","","","","",144.1,146.9,140.7,162.5,166.1,150.9,0.9003128258602711,-0.1515017224440392,0.031795982213425826,1.497627754631234,0.12685898268902854,0.8966787756305997,1957]
["High","P54578","Ubiquitin carboxyl-terminal hydrolase 14 [OS=Homo sapiens]",51,21,101,21,494,56,5.3,239.24,"protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","USP14","ENSG00000101557","","Ub-specific processing proteases","",4000.2,4062.6,3972.9,3930.9,3761.5,3838.1,1.0438142318199557,0.06186497754060374,0.03905164761854226,1.408360638187548,0.14444114855782947,0.8403090668365689,2111]
["High","P54687","Branched-chain-amino-acid aminotransferase, cytosolic [OS=Homo sapiens]",47,16,148,2,386,42.9,5.3,289.85,"cell cycle OR cell proliferation;other metabolic processes","cytosol;mitochondrion","other molecular function","BCAT1","ENSG00000060982","Amino acid metabolism; One-carbon metabolism and related pathways","Branched-chain amino acid catabolism","Cysteine and methionine metabolism; Valine, leucine and isoleucine degradation; Valine, leucine and isoleucine biosynthesis; Pantothenate and CoA biosynthesis; Metabolic pathways; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors",5810,5850.4,5905.6,6000.2,5954,6058.4,0.9752062445177264,-0.03622073092071271,0.022120701366927186,1.6552011072517272,0.10207945406203751,0.9910616612960965,1692]
["High","P54764","Ephrin type-A receptor 4 [OS=Homo sapiens]",5,3,3,3,986,109.8,6.61,10.23,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","EPHA4","ENSG00000116106","Spinal cord injury; Gene regulatory network modelling somitogenesis ; Fragile X syndrome; Somitogenesis in the context of spondylocostal dysostosis","EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse","Axon guidance",92.4,100.2,103.8,106.2,126.4,119.7,0.8413284132841329,-0.24925902718912982,0.05247740457055245,1.2800276524540588,0.17391492991802782,0.7596631339104873,2356]
["High","P54920","alpha-soluble nsf attachment protein [OS=Homo sapiens]",59,15,77,15,295,33.2,5.36,211.67,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","NAPA","ENSG00000105402","Synaptic vesicle pathway; VEGFA-VEGFR2 signaling pathway","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network; COPI-dependent Golgi-to-ER retrograde traffic; Intra-Golgi traffic","Synaptic vesicle cycle",2667.8,2792.5,2706.1,2551.9,2687,2673.1,1.032153690596562,0.045657808118396016,0.20828271781806387,0.681346763982292,0.4013503111360915,0.3964763960118994,4052]
["High","P55061","Bax inhibitor 1 [OS=Homo sapiens]",3,1,2,1,237,26.5,8.54,4.76,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","TMBIM6","ENSG00000139644","","","Pathogenic Escherichia coli infection",214.2,229.8,195.6,98.8,115.5,100.9,2.029187817258883,1.0209024040239558,6.424161510336509E-4,3.192183548961291,0.017978441961543894,1.7452479475762535,279]
["High","P55145","Mesencephalic astrocyte-derived neurotrophic factor [OS=Homo sapiens]",19,4,7,4,182,20.7,8.69,13.77,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","MANF","ENSG00000145050","Orexin receptor pathway","Platelet degranulation","",263.4,401.8,286.3,353.3,278.9,272.8,1.0513812154696132,0.07228586430345404,0.7722155433849496,0.11226146101503087,0.8734548692959129,0.05875952974470129,6903]
["High","P55265-1","Double-stranded RNA-specific adenosine deaminase [OS=Homo sapiens]",49,54,263,54,1226,136,8.65,499.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ADAR","ENSG00000160710","Measles virus infection; Cytosolic DNA-sensing pathway","Interferon alpha/beta signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins","Cytosolic DNA-sensing pathway; Measles; Influenza A; Coronavirus disease",12938.1,13034,13018.8,13820.6,14198.2,14318.5,0.9209585873449652,-0.11879181063950411,1.8775547435003043E-3,2.726407391499027,0.028355797750967845,1.547358129934334,517]
["High","P55786","puromycin-sensitive aminopeptidase [OS=Homo sapiens]",50,37,153,37,919,103.2,5.72,323.71,"protein metabolism;other metabolic processes;stress response","cytosol;nucleus;other cell component","other molecular function","NPEPPS","ENSG00000141279","","Antigen processing: Ubiquitination & Proteasome degradation","",6527.8,6553.3,6574.6,6799.8,7042.9,6932.3,0.9461227436823105,-0.07990073350602057,0.006455446099638615,2.19007374070706,0.05081060801005878,1.2940456082026035,992]
["High","P55854","Small ubiquitin-related modifier 3 [OS=Homo sapiens]",20,2,6,1,103,11.6,5.49,17.4,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SUMO3","ENSG00000184900","Exercise-induced circadian regulation","SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; SUMOylation of immune response proteins; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed","Nucleocytoplasmic transport; Fluid shear stress and atherosclerosis",437.7,462.1,438.8,415.1,349.9,413.1,1.1362363127069008,0.1842629155777435,0.07915843969201317,1.1015027748474906,0.2224070158745012,0.6528515169662271,2779]
["High","P56270-2","Isoform 2 of Myc-associated zinc finger protein [OS=Homo sapiens]",14,7,19,5,493,51,9.1,47.84,"","","","MAZ","","","","",577,598.2,672,764.4,772.1,862.9,0.769859131449529,-0.37733360875717037,0.012609362364527109,1.8993068744553852,0.07347306070315497,1.1338718681615574,1340]
["High","P56747","Claudin-6 [OS=Homo sapiens]",25,5,20,5,220,23.3,8,42.93,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CLDN6","ENSG00000184697","Epithelial to mesenchymal transition in colorectal cancer","Tight junction interactions","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Pathogenic Escherichia coli infection; Hepatitis C",895.8,892.2,922.7,664.2,636.2,692.3,1.3603151502985897,0.4439409258150377,2.2107862219863085E-4,3.65545325068243,0.012071201972915453,1.9182494834888562,143]
["High","P57060","RWD domain-containing protein 2B [OS=Homo sapiens]",5,1,1,1,319,36.3,5.87,4.78,"","","","RWDD2B","ENSG00000156253","","","",71.8,74.2,69.3,53.4,59.8,66.5,{"$f":"AVERAGE(T2370:V2370)/AVERAGE(W2370:Y2370)","v":1.19810795770729},{"$f":"LOG(Z2370,2)","v":0.2607579106572919},{"$f":"TTEST(T2370:V2370,W2370:Y2370,2,2)","v":0.04243820030002384},{"$f":"-LOG10(AB2370)","v":1.3722430417438676},{"$f":"AB2370*7808/AF2370","v":0.15178995324900876},{"$f":"-LOG10(AD2370)","v":0.8187569727943713},2183]
["High","P57081-1","tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 [OS=Homo sapiens]",10,2,2,2,412,45.5,7.11,3.57,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","","WDR4","ENSG00000160193","","tRNA modification in the nucleus and cytosol","",20.4,17.9,16,23.2,20.8,22.7,0.8140929535232383,-0.2967345633802236,0.0481292875914814,1.3175905666911913,0.16446104048765284,0.783936966438425,2285]
["High","P57772","selenocysteine-specific elongation factor [OS=Homo sapiens]",9,5,17,5,596,65.3,8.35,38.67,"protein metabolism;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EEFSEC","ENSG00000132394; ENSG00000284869","","Selenocysteine synthesis","",1679.3,1793.5,1711.1,1401.3,1404.4,1386.9,1.236440394981634,0.30619269347869754,6.6050151628016291E-4,3.180126181060276,0.018223306851998276,1.739372811925931,283]
["High","P58107","epiplakin [OS=Homo sapiens]",32,43,92,40,5090,555.3,5.6,194.31,"","","","","","","","",2848.1,2836.6,2795,2157.3,2117.2,2129.1,1.3242082578549568,0.40513003222616417,4.1939614879698059E-6,5.377375561862805,0.004093306412258531,2.3879257441961133,8]
["High","P60033","CD81 antigen [OS=Homo sapiens]",18,2,18,2,236,25.8,5.29,45.32,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","CD81","ENSG00000110651","B cell receptor signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; IL-18 signaling pathway; 16p11.2 distal deletion syndrome","Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","B cell receptor signaling pathway; Malaria; Hepatitis C",566.7,578.1,639.1,429.5,414.1,447.5,1.3816900317558671,0.46643399792143925,0.002559631216097812,2.59182260201273,0.03132539268854501,1.5041034760752567,638]
["High","P60660","Myosin light polypeptide 6 [OS=Homo sapiens]",39,6,24,5,151,16.9,4.65,59.47,"developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL6","ENSG00000092841","Ciliary landscape","Smooth Muscle Contraction; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; RHO GTPases activate PKNs","Vascular smooth muscle contraction; Tight junction; Oxytocin signaling pathway",760.2,809.3,805.3,827.5,755.1,729,1.0273403703062813,0.03891424319306554,0.5625087814301007,0.24987069331105782,0.7342140697770355,0.1341772973477218,5982]
["High","P60763","Ras-related C3 botulinum toxin substrate 3 [OS=Homo sapiens]",26,5,33,1,192,21.4,8.15,80.24,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","RAC3","ENSG00000169750","Integrin-mediated cell adhesion; RalA downstream regulated genes; Focal adhesion; MAPK signaling pathway; Microglia pathogen phagocytosis pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Regulation of actin cytoskeleton","RAC3 GTPase cycle; PCP/CE pathway","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Wnt signaling pathway; Axon guidance; VEGF signaling pathway; Focal adhesion; Adherens junction; Natural killer cell mediated cytotoxicity; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Regulation of actin cytoskeleton; Yersinia infection; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer; Choline metabolism in cancer; Viral myocarditis; Fluid shear stress and atherosclerosis",65.9,55.4,86.1,60.2,61,77.4,1.0443101711983889,0.06255027128485202,0.7958815842411187,0.09915154424258944,0.8872420630717668,0.051957876995362556,7004]
["High","P61006","Ras-related protein Rab-8A [OS=Homo sapiens]",31,6,18,3,207,23.7,9.07,30.45,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB8A","ENSG00000167461","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape; Joubert syndrome","Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB geranylgeranylation; Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs; VxPx cargo-targeting to cilium","Autophagy; Endocytosis; AMPK signaling pathway; Tight junction; Pancreatic secretion; Amyotrophic lateral sclerosis; Pathways of neurodegeneration",205.5,219.2,232.1,225.7,213.7,248.2,0.9552065154159396,-0.06611541770025611,0.4641205210167362,0.33336922889339476,0.6545977290640672,0.18402550568346077,5536]
["High","P61088","ubiquitin-conjugating enzyme E2 N [OS=Homo sapiens]",48,6,56,6,152,17.1,6.57,137.06,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2N","ENSG00000177889","IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway; 3q29 copy number variation syndrome","ISG15 antiviral mechanism; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Nonhomologous End-Joining (NHEJ); Aggrephagy; E3 ubiquitin ligases ubiquitinate target proteins; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; Formation of Incision Complex in GG-NER; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Ubiquitin mediated proteolysis; Shigellosis",3206.5,3317.8,3123.2,3086.5,3127,2980.8,1.049291408807631,0.06941539827516381,0.10132172171582819,0.9942974390420639,0.25794587647772627,0.5884714103659141,3067]
["High","P61158","actin-related protein 3 [OS=Homo sapiens]",58,22,178,18,418,47.3,5.88,454.13,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ACTR3","ENSG00000115091","Physico-chemical features and toxicity-associated pathways","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Clathrin-mediated endocytosis","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",7869.7,7856.2,8064.3,8384.7,8381.1,8435.3,0.9440143485800223,-0.0831193068384648,0.002484008887085997,2.6048468547090224,0.030982653978222786,1.5088813832608168,626]
["High","P61289-1","Proteasome activator complex subunit 3 [OS=Homo sapiens]",54,15,134,15,254,29.5,5.95,309.53,"cell cycle OR cell proliferation;protein metabolism;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","HEL-S-283; LOC101359250; LOC103001388; LOC111151323; LOC111166421; Psme3; PSME3","ENSBTAG00000019918; ENSCAFG00000014716; ENSCATG00000043580; ENSCCAG00000025926; ENSCGRG00001014333; ENSCGRG00015000348; ENSECAG00000012620; ENSG00000131467; ENSGGOG00000010707; ENSLAFG00000013446; ENSMLUG00000004084; ENSMMUG00000012685; ENSMNEG00000003232; ENSMPUG00000010027; ENSMUSG00000078652; ENSNVIG00000013505; ENSOARG00000003731; ENSOGAG00000009420; ENSPPAG00000043945; ENSPTRG00000009225; ENSPTRG00000049975; ENSRBIG00000001980; ENSRNOG00000051344; ENSSBOG00000024784; ENSSSCG00000017385; ENSSSCG00005010026; ENSSSCG00015075406; ENSSSCG00025054060; ENSSSCG00030072129; ENSSSCG00035013193; ENSSSCG00040025703; ENSSSCG00045007466; ENSSSCG00050060716; ENSSSCG00055025037; ENSSSCG00060042579; ENSSSCG00065003129; ENSSSCG00070012475; ENSSSUG00005017981; ENSSTOG00000028833; ENSTSYG00000002969; ENSUAMG00000013177; ENSUMAG00000025062","Proteasome degradation; Proteasome degradation; Proteasome degradation; Proteasome degradation","Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Hedgehog ligand biogenesis; Hedgehog 'on' state; Regulation of expression of SLITs and ROBOs; ER-Phagosome pathway; Degradation of beta-catenin by the destruction complex; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Downstream TCR signaling; FCERI mediated NF-kB activation; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; FCERI mediated NF-kB activation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; UCH proteinases; ABC-family proteins mediated transport; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Hedgehog ligand biogenesis; Degradation of beta-catenin by the destruction complex; Downstream TCR signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of RUNX3 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Regulation of RAS by GAPs; Autodegradation of the E3 ubiquitin ligase COP1; Neddylation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Separation of Sister Chromatids; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX3 expression and activity; Regulation of PTEN stability and activity; Antigen processing: Ubiquitination & Proteasome degradation","Proteasome; Antigen processing and presentation; Hepatitis C",3467.3,3706.5,3420.3,3287.3,3481.8,3373.2,1.044546108870769,0.0628761779684253,0.22469436231557346,0.6484078240915646,0.420118194674329,0.3766285094271349,4176]
["High","P61326","Protein mago nashi homolog [OS=Homo sapiens]",42,10,73,10,146,17.2,6.11,194.65,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","","MAGOH","ENSG00000162385","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",3976.5,4660.3,3667.8,3706.2,4617.5,4110.7,0.9895612172682234,-0.015139135348358776,0.9179133575215865,0.037198310221525054,0.9565017343558718,0.019314238160990715,7493]
["High","P61803","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [OS=Homo sapiens]",19,2,9,2,113,12.5,7.08,17.53,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity","DAD1","ENSG00000129562","","Asparagine N-linked glycosylation; Maturation of spike protein","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum",376.4,399.4,355.7,349.6,386.5,366.2,1.0264900662251657,0.03771966594915884,0.5875526483597326,0.23095321183466952,0.7504680317999006,0.12466780296581435,6113]
["High","P61966","AP-1 complex subunit sigma-1A [OS=Homo sapiens]",16,2,4,2,158,18.7,5.73,11.33,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","AP1S1","ENSG00000106367","","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","Lysosome; Human immunodeficiency virus 1 infection",92.4,84.1,91.6,82.2,84.4,99,1.0094126506024095,0.013516072635636207,0.8944589905050969,0.0484395663382182,0.9442855324315571,0.024896664166718267,7396]
["High","P61978-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein K [OS=Homo sapiens]",65,30,512,1,440,48.5,5.54,787.75,"","","","HNRNPK","","","","",21926.8,20930.2,22337.9,24622.1,23389.7,23848.8,0.907241242071455,-0.14044186997367644,0.01573282871665402,1.8031931854767074,0.0835659364759419,1.0779707155662481,1470]
["High","P62191","26S proteasome regulatory subunit 4 [OS=Homo sapiens]",64,24,191,22,440,49.2,6.21,407.77,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMC1","ENSG00000100764","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; N-glycan trimming in the ER and Calnexin/Calreticulin cycle","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human papillomavirus infection; Epstein-Barr virus infection; Viral carcinogenesis",6185.6,6075,6299,6483.3,6297.4,6270.1,0.9742163058769184,-0.03768596450011452,0.15346199413786454,0.8139991627269461,0.33488855512253946,0.47509969429966487,3578]
["High","P62263","40S ribosomal protein S14 [OS=Homo sapiens]",38,7,101,7,151,16.3,10.05,285.12,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","RPS14","ENSG00000164587","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); rRNA modification in the nucleus and cytosol","Ribosome; Coronavirus disease",3849.4,3901.9,3931.1,3388.7,3818.8,3816.2,1.0597530774603807,0.08372815590032937,0.20432531862208153,0.6896778151758136,0.3969574739490452,0.401256016709213,4019]
["High","P62306","Small nuclear ribonucleoprotein F [OS=Homo sapiens]",15,1,10,1,86,9.7,4.67,8.85,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","SNRPF","ENSG00000139343","mRNA processing","snRNP Assembly; mRNA Splicing - Major Pathway; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","Spliceosome",302,312,235,239.8,273.2,236.3,1.133057520352329,0.18022110230639393,0.28398892310459983,0.5466985991373507,0.48435681773715933,0.3148345828172395,4578]
["High","P62316","Small nuclear ribonucleoprotein Sm D2 [OS=Homo sapiens]",56,6,37,6,118,13.5,9.91,74.8,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","SNRPD2","ENSG00000125743","mRNA processing","mRNA Splicing - Major Pathway; snRNP Assembly; mRNA Splicing - Minor Pathway","Spliceosome",1563.8,1710.3,1517.4,1944.8,1532.4,1478,0.966963997416855,-0.04846591947179704,0.7478646328996232,0.12617700441490584,0.8608767586142206,0.06505901682129257,6783]
["High","P62487","DNA-directed RNA polymerase II subunit rpb7 [OS=Homo sapiens]",51,6,18,6,172,19.3,5.54,34.5,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR2G","ENSG00000168002","Pyrimidine metabolism; Eukaryotic transcription initiation","Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; mRNA Splicing - Major Pathway; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Inhibition of DNA recombination at telomere; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","RNA polymerase; Huntington disease",417.4,399.5,388.6,426.7,455.7,441.3,0.9107048424869683,-0.13494453951747726,0.02929082358383512,1.5332684168849282,0.12126338841070235,0.9162703006276023,1886]
["High","P62699","Protein yippee-like 5 [OS=Homo sapiens]",23,2,4,2,121,13.8,7.31,8.83,"cell cycle OR cell proliferation","non-structural extracellular;cytoskeleton;nucleus;other cell component","other molecular function","YPEL5","ENSG00000119801","Ciliary landscape","Neutrophil degranulation","",82.5,99.4,91.2,87.2,81.6,81.5,1.0910906911705953,0.12577102307695448,0.2198597124574173,0.6578543443563393,0.4140532163211564,0.38294383745554594,4146]
["High","P62820","Ras-related protein Rab-1A [OS=Homo sapiens]",78,14,103,5,205,22.7,6.21,234.8,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB1A","ENSG00000138069","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization","Autophagy; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Legionellosis",5520.4,6183.2,5369.8,4801.1,5890.9,5316.3,1.0665342353654041,0.09293027641375246,0.4268833095398477,0.3696908250893458,0.6231267303957994,0.20542361832572748,5349]
["High","P62851","40S ribosomal protein S25 [OS=Homo sapiens]",37,5,10,5,125,13.7,10.11,15.49,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","other molecular function","RPS25","ENSG00000118181; ENSG00000280831","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",1087.7,1154.1,1008.3,1333.7,940.5,800.8,1.0569430894308944,0.079897697622939,0.7413997320691528,0.12994757525399966,0.8567188261056601,0.0671616895203393,6757]
["High","P62873","Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [OS=Homo sapiens]",52,11,53,6,340,37.4,6,145.37,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","cytoskeletal activity;other molecular function","GNB1","ENSG00000078369","Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells; Estrogen signaling pathway","G alpha (q) signalling events; Thrombin signalling through proteinase activated receptors (PARs); G alpha (i) signalling events; Inactivation, recovery and regulation of the phototransduction cascade; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (12/13) signalling events; Olfactory Signaling Pathway; G alpha (z) signalling events; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Sensory perception of sweet, bitter, and umami (glutamate) taste; Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation; Activation of the phototransduction cascade","Ras signaling pathway; Chemokine signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Olfactory transduction; Phototransduction; Relaxin signaling pathway; Morphine addiction; Alcoholism; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",2356.5,2456.2,2337.3,2189.9,2401.3,2411,1.0211076518808373,0.030134972628544508,0.5759054621253157,0.23964880242228206,0.7417799155847022,0.1297249297952501,6062]
["High","P62913","60S ribosomal protein L11 [OS=Homo sapiens]",33,6,50,6,178,20.2,9.6,106.77,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL11","ENSG00000142676","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",2937.9,2987.7,2574.8,2436.9,2728,2464.3,1.1141928380433075,0.15599894759015434,0.1433922950796648,0.8434741840537454,0.31997914832295593,0.4948783218780164,3499]
["High","P62979","Ubiquitin-40S ribosomal protein S27a [OS=Homo sapiens]",63,11,613,11,156,18,9.64,1106.78,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle","other molecular function","RPS27A","ENSG00000143947","Cytoplasmic ribosomal proteins","Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Glycogen synthesis; Cargo recognition for clathrin-mediated endocytosis; InlA-mediated entry of Listeria monocytogenes into host cells; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Stimuli-sensing channels; Negative regulation of MAPK pathway; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oncogene Induced Senescence; ISG15 antiviral mechanism; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Orc1 removal from chromatin; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Regulation of PLK1 Activity at G2/M Transition; Peroxisomal protein import; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of PTEN stability and activity; Downregulation of ERBB4 signaling; Regulation of PTEN localization; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Oxidative Stress Induced Senescence; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Regulation of TP53 Degradation; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; ER Quality Control Compartment (ERQC); Deactivation of the beta-catenin transactivating complex; Circadian Clock; Regulation of signaling by CBL; Metalloprotease DUBs; Regulation of necroptotic cell death; Cyclin D associated events in G1; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Inactivation of CSF3 (G-CSF) signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Regulation of BACH1 activity; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Negative regulators of DDX58/IFIH1 signaling; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Formation of TC-NER Pre-Incision Complex; Modulation by Mtb of host immune system; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Formation of Incision Complex in GG-NER; Iron uptake and transport; Myoclonic epilepsy of Lafora; DNA Damage Recognition in GG-NER; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Ribosome; Ubiquitin mediated proteolysis; Mitophagy; Parkinson disease; Pathways of neurodegeneration; Shigellosis; Kaposi sarcoma-associated herpesvirus infection; Coronavirus disease",19412.2,19795.6,19598.4,19506.8,17752.8,18028.3,1.0636359854507045,0.08900449309520715,0.10245132832252898,0.9894824064242821,0.2592158041290688,0.5863385234927762,3086]
["High","P63096-1","Guanine nucleotide-binding protein G(i) subunit alpha-1 [OS=Homo sapiens]",30,9,17,4,354,40.3,5.97,37.11,"cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","Gnai1; GNAI1; LOC101343271; LOC111155312","ENSANAG00000026023; ENSBTAG00000002714; ENSCANG00000034777; ENSCCAG00000031786; ENSCGRG00001015780; ENSCGRG00015010768; ENSCHIG00000023476; ENSCSAG00000011871; ENSFCAG00000007172; ENSG00000127955; ENSGGOG00000008064; ENSLAFG00000022531; ENSLCNG00005007413; ENSMMUG00000023470; ENSMNEG00000038772; ENSMPUG00000018288; ENSMUSG00000057614; ENSPCTG00005000350; ENSPTRG00000019343; ENSSSCG00000015407; ENSSSCG00070000597; ENSSSUG00005001506; ENSTSYG00000026142; ENSTTRG00000006465; ENSVVUG00000019537","Calcium regulation in cardiac cell; G protein signaling pathways; S1P receptor signal transduction; Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Chemokine signaling pathway; G protein signaling pathways; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Common pathways underlying drug addiction; Nicotine activity on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone; G protein signaling pathways; Cell-type dependent selectivity of CCK2R signaling; Chemokine signaling pathway; Purinergic signaling; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Calcium regulation in cardiac cells; Signal transduction of S1P receptor; Serotonin HTR1 group and FOS pathway; Calcium regulation in cardiac cells; G protein signaling pathways","G alpha (i) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Extra-nuclear estrogen signaling; G alpha (i) signalling events; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Adenylate cyclase inhibitory pathway; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion; Adenylate cyclase inhibitory pathway; G alpha (i) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12","Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Axon guidance; Apelin signaling pathway; Gap junction; Platelet activation; Leukocyte transendothelial migration; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Long-term depression; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Gastric acid secretion; Parkinson disease; Cocaine addiction; Morphine addiction; Alcoholism; Pertussis; Chagas disease; Toxoplasmosis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Chemical carcinogenesis",246.8,261,247.3,199.5,270.9,230.6,1.0771754636233952,0.10725327298415019,0.4426096611518321,0.3539791106547234,0.6377368950495488,0.19535845700847887,5419]
["High","P63167","Dynein light chain 1, cytoplasmic [OS=Homo sapiens]",45,3,7,2,89,10.4,7.4,14.67,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","DYNLL1","ENSG00000088986","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome","Neutrophil degranulation; MHC class II antigen presentation; COPI-mediated anterograde transport; HCMV Early Events; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria","Vasopressin-regulated water reabsorption; Salmonella infection",206.5,229.6,222,238.6,180.9,199.3,1.0635100193923726,0.08883362508005964,0.5141764399257126,0.288887827041025,0.6971157567181739,0.15669510091229594,5759]
["High","P63279","SUMO-conjugating enzyme ubc9 [OS=Homo sapiens]",6,1,9,1,158,18,8.66,16.67,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2I","ENSG00000103275","Androgen receptor signaling pathway; TGF-beta signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of RNA binding proteins; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Processing of DNA double-strand break ends; Formation of Incision Complex in GG-NER; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)","Nucleocytoplasmic transport; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; MicroRNAs in cancer",574.7,589.5,529.2,678.8,418,440,1.1019000520562208,0.1399933700595036,0.574314279291027,0.240850385633853,0.7413202004801354,0.1299941654825683,6049]
["High","P68133","Actin, alpha skeletal muscle [OS=Homo sapiens]",40,17,1318,3,377,42,5.39,2621.67,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTA1","ENSG00000143632","Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Malignant pleural mesothelioma","Striated Muscle Contraction","",18415.5,18185.2,19605.2,14796.9,14007.9,14323.1,1.3032375793859658,0.38210011027448815,9.2546525683224524E-4,3.0336398805839697,0.02052850206064253,1.6876427394034654,352]
["High","P68431","Histone H3.1 [OS=Homo sapiens]",57,8,86,1,136,15.4,11.12,147.96,"cell organization and biogenesis","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","H3C1; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8","ENSG00000197153; ENSG00000197409; ENSG00000273983; ENSG00000274750; ENSG00000275379; ENSG00000275714; ENSG00000277775; ENSG00000278828; ENSG00000286522; ENSG00000287080","Histone modifications; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma","Estrogen-dependent gene expression; Transcriptional regulation by small RNAs; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; HATs acetylate histones; Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Amyloid fiber formation; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Transcriptional regulation of granulopoiesis; B-WICH complex positively regulates rRNA expression; SIRT1 negatively regulates rRNA expression; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Late Events; HCMV Early Events; Formation of the beta-catenin:TCF transactivating complex; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Meiotic recombination; Assembly of the ORC complex at the origin of replication; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Interleukin-7 signaling; RMTs methylate histone arginines; PKMTs methylate histone lysines","Neutrophil extracellular trap formation; Alcoholism; Shigellosis; Transcriptional misregulation in cancer; Systemic lupus erythematosus",5061.9,6260.1,4285.6,3966,4248.3,3727.4,1.306983092859476,0.3862404785430205,0.10867744631451563,0.9638605751174559,0.26912575351212753,0.5700447412067252,3153]
["High","P78324","tyrosine-protein phosphatase non-receptor type substrate 1 [OS=Homo sapiens]",12,4,5,4,504,54.9,6.98,7.62,"cell adhesion;stress response;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","SIRPA","ENSG00000198053","Prolactin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Male infertility","Neutrophil degranulation; Cell surface interactions at the vascular wall; Signal regulatory protein family interactions","Osteoclast differentiation",135.3,109.5,139.3,207.2,153.8,195.9,0.6897108996229125,-0.5359363287659467,0.037160654073033816,1.4299166504962262,0.14064487978780807,0.8518760738107423,2063]
["High","P78362-1","SRSF protein kinase 2 [OS=Homo sapiens]",22,15,40,11,688,77.5,4.97,74.58,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","SRPK2","ENSG00000135250","mRNA processing","Maturation of nucleoprotein","",1272.5,1290.6,1248.9,1317.1,1231.3,1294.2,0.9920366418570761,-0.011534685919156936,0.7371875451726744,0.1324220108220272,0.8537467150264375,0.0686709543483449,6742]
["High","P78368","casein kinase I isoform gamma-2 [OS=Homo sapiens]",10,4,6,1,415,47.4,9.06,10.9,"cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK1G2","ENSG00000133275","Hedgehog signaling pathway","Disassembly of the destruction complex and recruitment of AXIN to the membrane; Sphingolipid de novo biosynthesis","Hedgehog signaling pathway",342.9,359.2,340.9,357.3,384.8,374.1,0.93442035477513,-0.09785639364321796,0.06899979055584449,1.1611522275320063,0.20445934142695776,0.6893930424219364,2635]
["High","P78536-1","Disintegrin and metalloproteinase domain-containing protein 17 [OS=Homo sapiens]",15,11,15,11,824,93,5.76,25,"cell adhesion;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM17","ENSG00000151694; ENSPPAG00000038185","Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Notch signaling; Copper homeostasis; Ebola virus infection in host; Soluble ACE2-mediated cell entry of SARS-CoV-2; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Notch signaling pathway","Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; Release of Hh-Np from the secreting cell; Growth hormone receptor signaling; Nuclear signaling by ERBB4; TNF signaling; CD163 mediating an anti-inflammatory response; Regulated proteolysis of p75NTR","Notch signaling pathway; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Coronavirus disease",465.5,485.4,515.1,510.4,533.3,502,0.9484376010868865,-0.07637523486557336,0.19692178903705998,0.7057062273102424,0.38856844296218457,0.4105324729176347,3957]
["High","P78563-1","Double-stranded RNA-specific editase 1 [OS=Homo sapiens]",1,1,2,1,741,80.7,9.01,3.57,"cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ADARB1","ENSG00000197381","","C6 deamination of adenosine; Formation of editosomes by ADAR proteins","",72.7,92,92.1,74.2,63,67.1,1.2569750367107193,0.3299559983890755,0.07278753994390903,1.1379429585543355,0.21135184525178197,0.6749939561190016,2689]
["High","P81605","Dermcidin [OS=Homo sapiens]",16,2,3,2,110,11.3,6.54,2.57,"protein metabolism;stress response;other biological processes","non-structural extracellular","other molecular function","DCD","ENSG00000161634","","Antimicrobial peptides","",54.6,60.2,49,49.6,51.9,62.3,1,0,1,0,1.000769033581133,-3.3385868286282057E-4,7802]
["High","P82912-1","28S ribosomal protein S11, mitochondrial [OS=Homo sapiens]",29,3,6,3,194,20.6,10.81,19.37,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS11","ENSG00000181991","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",284.8,297.2,257.1,290.9,300.4,291.8,0.9501755180613748,-0.07373405970928955,0.2967538335977946,0.5276036619281682,0.49796989742780584,0.30279690980280016,4653]
["Medium","P83369","U7 snRNA-associated Sm-like protein LSm11 [OS=Homo sapiens]",3,1,1,1,360,39.5,10.99,2.63,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","LSM11","ENSG00000155858","","RNA Polymerase II Transcription Termination; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","",27,26.7,16.1,27.7,24.4,27,0.8824273072060684,-0.1804506582631393,0.4517842569162838,0.345068906778891,0.6444156883453314,0.19083389519436048,5474]
["High","P84022","Mothers against decapentaplegic homolog 3 [OS=Homo sapiens]",10,4,8,1,425,48.1,7.15,23.23,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","SMAD3","ENSG00000166949","Androgen receptor signaling pathway; Cell cycle; AGE/RAGE pathway; Adipogenesis; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Ovarian infertility; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularisation processes; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; TGF-beta receptor signaling; DNA damage response (only ATM dependent)","Ub-specific processing proteases; Interleukin-37 signaling; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX3 regulates BCL2L11 (BIM) transcription; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates CDKN1A transcription; NOTCH4 Intracellular Domain Regulates Transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer","FoxO signaling pathway; Cell cycle; Endocytosis; Cellular senescence; Wnt signaling pathway; TGF-beta signaling pathway; Apelin signaling pathway; Hippo signaling pathway; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Th17 cell differentiation; AGE-RAGE signaling pathway in diabetic complications; Hepatitis B; Human T-cell leukemia virus 1 infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer; Chronic myeloid leukemia; Hepatocellular carcinoma; Gastric cancer; Inflammatory bowel disease; Diabetic cardiomyopathy",189.5,189.4,189.7,232.6,217.6,240.5,0.823222817431591,-0.28064512463411034,3.743674296257422E-3,2.4267019423834966,0.03737929527516362,1.4273688907847093,782]
["High","P84103","Serine/arginine-rich splicing factor 3 [OS=Homo sapiens]",43,9,79,8,164,19.3,11.65,141.64,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SRSF3","ENSG00000112081","mRNA processing","mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection",2842.2,2836.9,3120.8,3026.4,2950.1,3123.2,0.967053858918426,-0.048331853757406756,0.400397198502384,0.3975089698520899,0.5991378547157176,0.22247323995765642,5218]
["High","P86397","Hydroxyacyl-thioester dehydratase type 2, mitochondrial [OS=Homo sapiens]",17,1,2,1,168,18.5,8.92,5.04,"other metabolic processes","mitochondrion;nucleus","other molecular function","HTD2","ENSG00000255154","Mitochondrial fatty acid synthesis pathway","Fatty acyl-CoA biosynthesis","Fatty acid biosynthesis; Metabolic pathways; Fatty acid metabolism",29.7,26.5,25.6,29.7,28.1,31.8,0.9129464285714287,-0.13139788911585507,0.18845310762834674,0.7247966965549709,0.378359954837267,0.42209483504379525,3889]
["High","P98171-1","Rho GTPase-activating protein 4 [OS=Homo sapiens]",7,5,7,5,946,105,6.34,7.93,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","ARHGAP4","ENSG00000089820","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle","",376.7,367.1,396.3,432.1,412.3,407.8,0.9104775594952882,-0.13530463529516615,0.030412750870471184,1.516944295612726,0.12387207031645227,0.907026603832153,1917]
["High","P98198-1","Phospholipid-transporting ATPase ID [OS=Homo sapiens]",4,3,6,3,1209,137.4,7.01,5.74,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi","transporter activity;other molecular function","ATP8B2","ENSG00000143515; ENSPPAG00000034141; ENSPTRG00000001382","Mesodermal commitment pathway; Complement system in neuronal development and plasticity","Ion transport by P-type ATPases","",184.4,174.7,152.1,162.2,171.7,174.8,1.0049144879103598,0.007072742084365659,0.9393576910515102,0.02716900446430433,0.969403231790932,0.0134955367623942,7566]
["High","Q00341-1","Vigilin [OS=Homo sapiens]",48,53,183,52,1268,141.4,6.87,403.1,"other metabolic processes;transport","non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","HDLBP","ENSG00000115677","","HDL clearance","",6932.5,6777.7,6713,6906.4,7166.8,6984.7,0.9698592927119988,-0.044152638753956315,0.10414610211648437,0.9823569797822974,0.26163859888208174,0.5822981852525386,3108]
["High","Q00688","peptidyl-prolyl cis-trans isomerase FKBP3 [OS=Homo sapiens]",54,10,29,10,224,25.2,9.28,56.54,"protein metabolism;other metabolic processes","nucleus","other molecular function","FKBP3","ENSG00000100442","","","",1317.4,1332.8,1381.5,1648.9,1416.5,1349.8,0.913140967566588,-0.1310904991790632,0.23993128548387585,0.619913119155401,0.43688980341840083,0.3596280911814792,4288]
["High","Q01081","Splicing factor U2AF 35 kDa subunit [OS=Homo sapiens]",47,8,66,8,240,27.9,8.81,83.97,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","U2AF1","ENSG00000160201","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","Spliceosome; Shigellosis",2192,2174.4,2371.6,2320.7,2166.2,2260.8,0.9985624731389956,-2.0754049563581315E-3,0.9686846259868239,0.013817592904933952,0.9843167048028528,6.865144435954598E-3,7684]
["High","Q01082-1","Spectrin beta chain, non-erythrocytic 1 [OS=Homo sapiens]",69,146,748,14,2364,274.4,5.57,1717.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SPTBN1","ENSG00000115306; ENSPPAG00000020369; ENSPTRG00000011924","TGF-beta signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways","RHOV GTPase cycle; RHOU GTPase cycle; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Signaling by FLT3 fusion proteins; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Nephrin family interactions; Interaction between L1 and Ankyrins","",29711,28417.7,30100.2,30518,30612.4,30555.3,0.9622972830005115,-0.055445439503948236,0.0864345069198749,1.0633128411662902,0.23392742808678796,0.6309188539994051,2885]
["High","Q01518-1","adenylyl cyclase-associated protein 1 [OS=Homo sapiens]",52,23,219,1,475,51.9,8.06,510.69,"cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CAP1","ENSG00000131236","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity","Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling","",202.1,179.3,217,196.5,199.9,201.9,1.0001671402306536,2.4111223268109887E-4,0.9977426979503362,9.8144194682564046E-4,0.9994066690950898,2.5775681305073572E-4,7795]
["High","Q01780","exosome component 10 [OS=Homo sapiens]",34,27,72,27,885,100.8,8.46,142.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","EXOSC10","ENSG00000171824","","Major pathway of rRNA processing in the nucleolus and cytosol","RNA degradation",2902.4,2723.3,2898.4,3218.3,3295.4,3227.2,0.8750834111837714,-0.1925075566099796,3.1502608616382297E-3,2.5016534823757026,0.03406819502447548,1.4676508752867061,722]
["High","Q01844","RNA-binding protein EWS [OS=Homo sapiens]",7,4,36,4,656,68.4,9.33,89.93,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","EWSR1","ENSG00000182944","VEGFA-VEGFR2 signaling pathway","","Transcriptional misregulation in cancer",1436.8,1178,1305.7,1561.1,1298.1,1445.3,0.9107910326402602,-0.1348080076608659,0.29626827599770683,0.528314849690231,0.4977970086055724,0.30294771751046407,4647]
["High","Q01970-1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [OS=Homo sapiens]",34,32,82,32,1234,138.7,5.9,165.67,"other metabolic processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","other molecular function","PLCB3","ENSG00000149782","Alzheimer's disease and miRNA effects; S1P receptor signal transduction; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; GPR40 pathway; MAPK cascade; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; Calcium regulation in cardiac cells","G alpha (q) signalling events; Synthesis of IP3 and IP4 in the cytosol; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Inositol phosphate metabolism; Metabolic pathways; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Apelin signaling pathway; Gap junction; Platelet activation; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Pathways in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis",3085.6,2856.8,3362.6,3190.4,2968.5,3310.1,0.9826803252719399,-0.025205923643857445,0.7730938072290946,0.11176780557693479,0.873562438038317,0.05870604829249781,6910]
["High","Q02127","Dihydroorotate dehydrogenase (Quinone), mitochondrial [OS=Homo sapiens]",17,5,9,5,395,42.8,9.67,20.63,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","DHODH","ENSG00000102967","Pyrimidine metabolism","Pyrimidine biosynthesis","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",295.1,282.6,332.5,315.7,282.7,325.3,0.9853848652159792,-0.021240781797783728,0.8311703183374468,0.08030997412800074,0.9104626607153177,0.040737860498183745,7128]
["High","Q02318","Sterol 26-hydroxylase, mitochondrial [OS=Homo sapiens]",10,5,7,5,531,60.2,8.9,11.54,"other metabolic processes","other membranes;mitochondrion","other molecular function","CYP27A1","ENSG00000135929","Vitamin D metabolism; PPAR signaling pathway; Oxidation by cytochrome P450; Vitamin D-sensitive calcium signaling in depression; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Metapathway biotransformation Phase I and II","Endogenous sterols; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol; Defective CYP27A1 causes CTX","Primary bile acid biosynthesis; Metabolic pathways; PPAR signaling pathway; Cholesterol metabolism",263.2,308.3,284.5,415.5,473,409,0.6597302504816955,-0.6000518368440964,3.6679646402791324E-3,2.4355748596447846,0.036764400399614205,1.4345725126587139,779]
["High","Q02880","DNA topoisomerase 2-beta [OS=Homo sapiens]",39,55,218,39,1626,183.2,8,460.98,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP2B","ENSG00000077097","","SUMOylation of DNA replication proteins","Platinum drug resistance",5241,5188.4,5268.9,5935.7,6314.1,6231.4,0.8494199510854274,-0.2354500999364789,1.3813810034148625E-3,2.8596865206542,0.025083309010844757,1.6006151715751513,430]
["High","Q03013-1","glutathione S-transferase mu 4 [OS=Homo sapiens]",46,9,31,2,218,25.5,5.9,59.38,"other metabolic processes","non-structural extracellular;cytosol;other cell component","other molecular function","GSTM4","ENSG00000168765","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II","Glutathione conjugation; Biosynthesis of maresin conjugates in tissue regeneration (MCTR)","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",48.9,60,62,64.7,60.9,64.6,0.8985278654048371,-0.15436484918442397,0.2056854051243633,0.6867965235645281,0.39860800278258346,0.3994539862942706,4029]
["High","Q03135","Caveolin-1 [OS=Homo sapiens]",27,4,6,4,178,20.5,6.02,10.73,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","CAV1","ENSG00000105974","Androgen receptor signaling pathway; Integrin-mediated cell adhesion; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host; Acute viral myocarditis; EGF/EGFR signaling pathway; Congenital generalized lipodystrophy (CGL)","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RND1 GTPase cycle; RHOH GTPase cycle; Basigin interactions; Triglyceride catabolism; RHOD GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; NOSTRIN mediated eNOS trafficking; RND3 GTPase cycle; Disassembly of the destruction complex and recruitment of AXIN to the membrane; FOXO-mediated transcription of cell cycle genes; VEGFR2 mediated vascular permeability; eNOS activation","Endocytosis; Focal adhesion; Prion disease; Bacterial invasion of epithelial cells; Proteoglycans in cancer; Viral myocarditis; Fluid shear stress and atherosclerosis",455.1,447.9,420.9,431,405,409.1,1.0632880893100958,0.08853253638811771,0.11689230417104664,0.9322140805068307,0.2812619756448481,0.5508889769845834,3245]
["High","Q03426","mevalonate kinase [OS=Homo sapiens]",15,4,12,4,396,42.4,6.46,11.91,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","MVK","ENSG00000110921","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Terpenoid backbone biosynthesis; Metabolic pathways; Peroxisome",263.9,273.6,297.8,292.5,291.9,287,0.9585724122102365,-0.0610406752102802,0.3046864717028128,0.5161468283347567,0.5048794505635743,0.2968123054551665,4712]
["High","Q04726","Transducin-like enhancer protein 3 [OS=Homo sapiens]",20,13,23,10,772,83.4,7.2,57.7,"cell-cell signaling;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","TLE3","ENSG00000140332","White fat cell differentiation","Estrogen-dependent gene expression; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes","Wnt signaling pathway; Notch signaling pathway",866.4,908.3,895.8,895.4,944,917.8,0.9685550558537647,-0.04609403619857709,0.19804063880306705,0.7032456814710343,0.38959468575821304,0.40938697571956223,3969]
["High","Q04727-1","Transducin-like enhancer protein 4 [OS=Homo sapiens]",16,10,20,2,773,83.7,7.5,44.85,"cell-cell signaling;signal transduction;other biological processes","nucleus;other cell component","other molecular function","TLE4","ENSG00000106829","","Formation of the beta-catenin:TCF transactivating complex; NOTCH1 Intracellular Domain Regulates Transcription; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes","Wnt signaling pathway; Notch signaling pathway",151.3,153.9,157.2,162.4,138.8,155.2,1.0131463628396145,0.018842606211997275,0.7946398545704088,0.09982965701794588,0.8866173170171123,0.052263790506198095,6998]
["High","Q05086","Ubiquitin-protein ligase E3A [OS=Homo sapiens]",27,22,39,22,875,100.6,5.22,96.32,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE3A","ENSG00000114062","Androgen receptor signaling pathway; MECP2 and associated Rett syndrome; Prader-Willi and Angelman syndrome; Synaptic signaling pathways associated with autism spectrum disorder","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis; Human papillomavirus infection; Viral carcinogenesis",1475.9,1517.4,1469.8,1375.7,1394.9,1382.5,1.0746430377308516,0.1038575219381865,0.002942952300244468,2.53121677694507,0.033302277623635954,1.47752606302369,690]
["High","Q05519","serine/arginine-rich splicing factor 11 [OS=Homo sapiens]",28,15,76,15,484,53.5,10.52,131.75,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","SRSF11","ENSG00000116754","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",4211.2,4197.1,4265.1,4439.4,4453.4,4532.7,0.9439797400469254,-0.08317219848614284,0.002161880616102562,2.6651682924361006,0.029718246215719724,1.5269768234884842,568]
["High","Q05932-1","Folylpolyglutamate synthase, mitochondrial [OS=Homo sapiens]",13,5,5,5,587,64.6,7.94,9.7,"cell cycle OR cell proliferation;other metabolic processes;developmental processes","other membranes;cytosol;mitochondrion;other cell component","other molecular function","FPGS","ENSG00000136877","Fluoropyrimidine activity","","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance",157.2,165.5,146.6,93.2,81.9,90.4,1.7676082862523537,0.8217985993367469,4.5651978073020278E-4,3.3405404000007484,0.015984333847270955,1.7963054583902738,223]
["High","Q06203","amidophosphoribosyltransferase [OS=Homo sapiens]",43,16,53,16,517,57.4,6.76,119.08,"cell cycle OR cell proliferation;other metabolic processes;transport;developmental processes;other biological processes","cytosol","other molecular function","PPAT","ENSG00000128059","Fluoropyrimidine activity; Metabolic reprogramming in colon cancer","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Alanine, aspartate and glutamate metabolism; Metabolic pathways",1821.8,1910.5,1835.2,1677.8,1750.9,1759,1.073211635214064,0.10193460076086337,0.028591447699363632,1.5437638540184606,0.11976503413982363,0.9216699573777878,1864]
["High","Q06546","GA-binding protein alpha chain [OS=Homo sapiens]",27,8,23,8,454,51.3,4.97,65,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GABPA","ENSG00000154727","Energy metabolism; Allograft rejection; Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression; Malignant pleural mesothelioma","Transcriptional activation of mitochondrial biogenesis","",726.4,675.3,699,780,731.6,743.2,0.9316569097037429,-0.10212932648531958,0.06859837252333542,1.1636861876827402,0.20365630899703535,0.6911021315138628,2630]
["High","Q06787","synaptic functional regulator FMR1 [OS=Homo sapiens]",16,10,25,2,632,71.1,7.42,45.38,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","FMR1","ENSG00000102081","Serotonin and anxiety; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome","","",842.5,789.6,862.9,889,881.5,868.1,0.9455772000303191,-0.08073284553916996,0.10244577377453161,0.9895059529705302,0.25928577038299605,0.5862213166811553,3085]
["High","Q07065","Cytoskeleton-associated protein 4 [OS=Homo sapiens]",67,40,173,40,602,66,5.92,454.28,"","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","","CKAP4","ENSG00000136026","","Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RND2 GTPase cycle; RND3 GTPase cycle; Surfactant metabolism","Protein processing in endoplasmic reticulum",7983.5,7651.2,8249.7,8886.8,8626.8,8541.2,0.9166986505365615,-0.12548054517603435,0.023105194913971037,1.6362903634488895,0.10476501851816833,0.9797837059078901,1722]
["High","Q07820","Induced myeloid leukemia cell differentiation protein Mcl-1 [OS=Homo sapiens]",49,10,31,10,350,37.3,5.66,88.8,"stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","transporter activity;other molecular function","MCL1","ENSG00000143384","Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-Akt signaling pathway; MicroRNA network associated with chronic lymphocytic leukemia; Host-pathogen interaction of human coronaviruses - apoptosis; Malignant pleural mesothelioma","Interleukin-4 and Interleukin-13 signaling","PI3K-Akt signaling pathway; Apoptosis; JAK-STAT signaling pathway; MicroRNAs in cancer",1019.9,1051,1026,829.5,792,816.9,1.2700541338582676,0.34488999068597137,1.1274605138314154E-4,3.947898659139949,9.26653862315336E-3,2.0330824597701618,95]
["High","Q07954","prolow-density lipoprotein receptor-related protein 1 [OS=Homo sapiens]",19,65,111,65,4544,504.3,5.39,219.85,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","LRP1","ENSG00000123384","Alzheimer's disease and miRNA effects; Regulation of Wnt / B-catenin signaling by small molecule compounds; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Alzheimer's disease","Retinoid metabolism and transport; Scavenging of heme from plasma","Cholesterol metabolism; Alzheimer disease; Malaria",3482.9,3401.1,3567.8,3980.1,3983.7,4102.8,0.8661760562213051,-0.20726780247290427,1.0162970725498134E-3,2.992979325407537,0.021217239418366157,1.673311122949382,374]
["High","Q08345-1","Epithelial discoidin domain-containing receptor 1 [OS=Homo sapiens]",1,1,1,1,913,101.1,6.83,3.57,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","DDR1","ENSG00000137332; ENSG00000204580; ENSG00000215522; ENSG00000230456; ENSG00000234078; ENSPPAG00000026163; ENSPTRG00000017942","Interactions between LOXL4 and oxidative stress pathway","Non-integrin membrane-ECM interactions","",55.4,45.4,64.5,99.3,65.5,79.6,0.6763502454991817,-0.5641575605264157,0.0790056801427361,1.102341683823902,0.2221376847513444,0.6533777589155242,2777]
["High","Q08623","Pseudouridine-5'-phosphatase [OS=Homo sapiens]",12,2,7,2,228,25.2,5.31,11.08,"other metabolic processes","cytosol","other molecular function","PUDP","ENSG00000130021","","Pyrimidine salvage","",160.9,168.9,167.2,156.9,154.9,165.3,1.0417103332634667,0.05895416546534353,0.1733475986686939,0.7610821701146443,0.3600686486845336,0.4436146911698214,3759]
["High","Q08AD1","Calmodulin-regulated spectrin-associated protein 2 [OS=Homo sapiens]",15,15,19,15,1489,168,6.8,35.55,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi","cytoskeletal activity;other molecular function","CAMSAP2","ENSG00000118200","","","",542.3,467.5,519.9,546.3,501.6,495.8,0.9909308803523998,-0.013143665175434126,0.8726131036757047,0.05917826967681459,0.9318056774480172,0.030674647743954193,7312]
["High","Q09028","Histone-binding protein RBBP4 [OS=Homo sapiens]",38,15,119,8,425,47.6,4.89,322.27,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBBP4","ENSG00000162521","Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Malignant pleural mesothelioma","RNA Polymerase I Transcription Initiation; HCMV Early Events; Transcriptional Regulation by E2F6; G1/S-Specific Transcription; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1","Cellular senescence",2359.1,2412.5,2461.4,2451.7,2466.7,2544.6,0.9691812943856358,-0.045161534462015235,0.13664198524922688,0.8644158368151905,0.309695390660657,0.5090652584001998,3445]
["Medium","Q09328","Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A [OS=Homo sapiens]",1,1,1,1,741,84.5,8.12,2.01,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","MGAT5","ENSG00000152127","","N-Glycan antennae elongation; Maturation of spike protein","N-Glycan biosynthesis; Metabolic pathways",56.6,65.3,76.6,53.9,60.8,56.3,1.1608187134502925,0.21514268225706012,0.2093072539040976,0.6792157201757371,0.40272820071049636,0.39498795821442884,4058]
["High","Q0VG06","Fanconi anemia core complex-associated protein 100 [OS=Homo sapiens]",8,4,5,4,881,93.4,5.29,13.18,"DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","nucleic acid binding activity","FAAP100","ENSG00000185504","DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",166.8,156.7,160,151.4,132.7,140.6,1.1384506710619258,0.18707178101680125,0.033839638175396654,1.470574289228426,0.13191207931777188,0.8797154338633667,2003]
["High","Q10589","bone marrow stromal antigen 2 [OS=Homo sapiens]",22,4,16,4,180,19.8,5.6,37.57,"stress response;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","BST2","ENSG00000130303","Ebola virus infection in host; Host-pathogen interaction of human coronaviruses - MAPK signaling","Neutrophil degranulation; Interferon alpha/beta signaling","Herpes simplex virus 1 infection; Human immunodeficiency virus 1 infection",589.8,615.8,589.3,853.7,835.5,819.3,0.7155272074945186,-0.48292146927554747,5.6428876436111141E-5,4.248498596946951,0.007729766091458873,2.1118336479608066,57]
["High","Q12767","Transmembrane protein 94 [OS=Homo sapiens]",2,2,2,2,1356,151.1,6.44,7.02,"","other membranes","","TMEM94","ENSG00000177728","","","",49.7,47.4,58.8,48.9,50,43.9,1.091736694677871,0.1266249486686849,0.33144584183709774,0.4795874250656123,0.5332637817976631,0.2730579117222625,4853]
["High","Q12797","Aspartyl/Asparaginyl beta-hydroxylase [OS=Homo sapiens]",32,18,71,18,758,85.8,5.01,161.12,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","ASPH","ENSG00000198363","","Stimuli-sensing channels; Ion homeostasis","Calcium signaling pathway; Cardiac muscle contraction",2569.8,2379.3,2553.5,2415.3,2360.7,2398.9,1.0456731104266264,0.0644319188192008,0.15834589541586708,0.8003931897681865,0.34182050080372967,0.4662018938711708,3617]
["High","Q12824-1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [OS=Homo sapiens]",43,14,64,14,385,44.1,6.23,125.24,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101347788; LOC111142756; Smarcb1; SMARCB1","ENSCAFG00000014105; ENSCATG00000029590; ENSCCAG00000036123; ENSCHIG00000019816; ENSCSAG00000011285; ENSDLEG00000015913; ENSECAG00000007797; ENSG00000099956; ENSG00000275837; ENSHGLG00000019077; ENSMFAG00000040790; ENSMLUG00000004975; ENSMMUG00000009098; ENSMNEG00000033936; ENSMUSG00000000902; ENSPANG00000026464; ENSPPAG00000028391; ENSRBIG00000027964; ENSRFEG00010017090; ENSRROG00000030710; ENSSBOG00000031674; ENSSSCG00000010070; ENSSSCG00070020965; ENSSSUG00005014167; ENSSTOG00000012408; ENSTSYG00000008262; ENSUAMG00000010813","TNF-alpha NF-kB signaling pathway; Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation","RMTs methylate histone arginines; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",1455.8,1445.8,1464.4,1584.6,1512.9,1572.4,0.9349236600355468,-0.09707952644804209,0.011292874333413543,1.9471955046415796,0.07031480286705977,1.1529532364776418,1254]
["High","Q12851","Mitogen-activated protein kinase kinase kinase kinase 2 [OS=Homo sapiens]",8,5,7,5,820,91.5,6.34,12.27,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","kinase activity;other molecular function","MAP4K2","ENSG00000168067","TNF-alpha signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma","","MAPK signaling pathway",106.4,86.7,101.6,105.5,116.1,107.3,0.8960170264518093,-0.1584019477114018,0.16772499878569141,0.7754022025963323,0.3523262820873496,0.4530549590334228,3717]
["High","Q12887","Protoheme IX farnesyltransferase, mitochondrial [OS=Homo sapiens]",4,1,1,1,443,48.9,9.19,2.28,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","COX10","ENSG00000006695","Mitochondrial complex IV assembly","Heme biosynthesis","Oxidative phosphorylation; Porphyrin metabolism; Metabolic pathways; Biosynthesis of cofactors; Thermogenesis",19,19.5,26,18,19.1,20.7,1.1159169550173011,0.1582296678099378,0.4024364644006486,0.39530267514271017,0.6010374739939297,0.22109844939258147,5228]
["High","Q12906-7","Isoform 7 of Interleukin enhancer-binding factor 3 [OS=Homo sapiens]",68,50,542,3,898,95.7,8.81,1315.87,"","","","ILF3","","","","",22485.6,21775.9,23031.1,24101.6,23152.1,23981,0.9446603972502167,-0.08213231715051288,0.049086029849017596,1.3090420928622537,0.1662749332152405,0.7791732179292852,2305]
["High","Q12959","Disks large homolog 1 [OS=Homo sapiens]",24,18,28,16,904,100.4,5.76,72.85,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","DLG1","ENSG00000075711","Brain-derived neurotrophic factor (BDNF) signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Disruption of postsynaptic signaling by CNV; 3q29 copy number variation syndrome","Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; NrCAM interactions; Activation of Ca-permeable Kainate Receptor","Hippo signaling pathway; Tight junction; T cell receptor signaling pathway; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Viral carcinogenesis",1310,1279.8,1326.3,1442.2,1413.4,1433.8,0.912971511167063,-0.13135825257409278,1.5032319417976761E-3,2.8229740045952045,0.025967334074239505,1.585572634747951,452]
["High","Q12974","Protein tyrosine phosphatase type IVA 2 [OS=Homo sapiens]",19,3,6,2,167,19.1,8.37,8.28,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PTP4A2","ENSG00000184007","","RAB geranylgeranylation","",245.9,241.1,234.7,219.8,234.3,230.5,1.0541922290388548,0.07613796241587462,0.08459902492156592,1.0726346425593662,0.23120377549443005,0.6360050782834739,2857]
["High","Q12999","Tetraspanin-31 [OS=Homo sapiens]",3,1,2,1,210,23,7.97,5.24,"other biological processes","plasma membrane;other membranes","","TSPAN31","ENSG00000135452","","","",110.5,92.5,110.7,104.1,108,123.8,0.9339089014587676,-0.09864626639089548,0.4343604310514228,0.3621497445580907,0.6306222100501133,0.20023073778673808,5378]
["High","Q13045-1","protein flightless-1 homolog [OS=Homo sapiens]",36,36,80,36,1269,144.7,6.05,191.17,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLII","ENSG00000177731; ENSG00000284571","VEGFA-VEGFR2 signaling pathway","","",3722.7,3684.3,3662.4,3680,3707.7,3631,1.0046012687522121,0.006623002162364803,0.5853522078790083,0.23258273919933375,0.7491280182132924,0.12544395953308585,6101]
["High","Q13111-1","Chromatin assembly factor 1 subunit A [OS=Homo sapiens]",25,17,31,17,956,106.9,5.94,52.65,"","","","","","","","",1291.7,1089.1,1231.8,1497.2,1402.2,1501.9,0.8208029445845545,-0.28489218834552127,0.01832134521322615,1.73704264217292,0.09100067647892479,1.0409553792176738,1572]
["High","Q13123","Protein Red [OS=Homo sapiens]",31,14,58,14,557,65.6,6.64,127.66,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","IK","ENSG00000113141","","","",2931.5,2791,2959.2,3251.5,3080.8,2900.9,0.9402698955941602,-0.08885316666474209,0.18160982207333395,0.7408606670655025,0.37004423036236733,0.4317463628133738,3832]
["High","Q13136","Liprin-alpha-1 [OS=Homo sapiens]",23,27,39,22,1202,135.7,6.29,100.62,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;other cell component","","PPFIA1","ENSG00000131626","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",2166,1898.1,1992.1,2109.1,1934.8,2052.2,0.9934548317776941,-0.009473719210776405,0.8940588438050829,0.048633896529769766,0.9441184003827545,0.024973538108222396,7394]
["High","Q13158","FAS-associated death domain protein [OS=Homo sapiens]",48,7,28,7,208,23.3,5.69,60.07,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","FADD","ENSG00000168040","TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor (RLR) pathway; VEGFA-VEGFR2 signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Alzheimer's disease; Toll-like receptor signaling pathway","Regulation of TNFR1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL  signaling; TLR3-mediated TICAM1-dependent programmed cell death; TNFR1-induced proapoptotic signaling; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis","Platinum drug resistance; Apoptosis; Apoptosis; Necroptosis; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Alcoholic liver disease; Alzheimer disease; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Salmonella infection; Chagas disease; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",821.2,929.7,792.7,874.7,886.1,856.1,0.9719897588750048,-0.04098698156873306,0.5973209222172207,0.22379227305746072,0.7577387101010655,0.12048052566616049,6155]
["High","Q13206","probable ATP-dependent RNA helicase DDX10 [OS=Homo sapiens]",22,18,36,18,875,100.8,8.63,70.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX10","ENSG00000178105","","","",1575,1556.8,1595.8,1569.5,1632.9,1658.6,0.972557087019132,-0.04014515919243979,0.19715644708496663,0.7051890167766801,0.38854051964649655,0.41056368332057297,3962]
["High","Q13257-1","Mitotic spindle assembly checkpoint protein MAD2A [OS=Homo sapiens]",35,8,25,8,205,23.5,5.08,53.29,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD2L1","ENSANAG00000022503; ENSCANG00000042550; ENSCATG00000040684; ENSCCAG00000030445; ENSG00000164109; ENSGGOG00000002516; ENSMLEG00000036707; ENSMMUG00000054168; ENSMNEG00000040691; ENSPANG00000019721; ENSPPAG00000028274; ENSPTRG00000016401; ENSRBIG00000035049; ENSRROG00000029952; ENSSBOG00000031396","Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; Cell cycle","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection",1241.1,1431.3,1224,1371.3,1604.7,1469.5,0.8764818355640536,-0.19020390237739881,0.12577246805370035,0.9004144167680624,0.29455051906517465,0.5308402076014136,3334]
["High","Q13283","Ras GTPase-activating protein-binding protein 1 [OS=Homo sapiens]",45,15,98,14,466,52.1,5.52,224.81,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","G3BP1","ENSG00000145907","","","",4706.2,4342.9,4707.1,4686.6,4104.8,4375.9,1.0447244309767376,0.06312244996975763,0.39718860680580037,0.401003217559177,0.596279300507535,0.22455026667537373,5201]
["High","Q13362","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [OS=Homo sapiens]",13,7,13,4,524,61,6.87,26.83,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","PPP2R5C","ENSG00000078304","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)","Platelet sensitization by LDL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF activation; Negative regulation of MAPK pathway; CTLA4 inhibitory signaling","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; Dopaminergic synapse; Human papillomavirus infection",368.7,433.1,414.3,413,424.2,421.6,0.9660788052113121,-0.04978721716132515,0.5041793859529291,0.29741491500608,0.6879819373506589,0.1624229638166885,5722]
["High","Q13367","AP-3 complex subunit beta-2 [OS=Homo sapiens]",23,20,42,15,1082,119,5.59,85.06,"transport","other membranes;ER/Golgi;other cell component","","AP3B2","ENSG00000103723","","","Lysosome",1173.9,1161.9,1205.3,942.7,991.9,977.3,1.2160788488615684,0.2822367741545504,4.2363794491997889E-4,3.373005147404677,0.015751262256834264,1.8026846374799605,210]
["High","Q13418","Integrin-linked protein kinase [OS=Homo sapiens]",24,12,25,12,452,51.4,8.07,41.21,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ILK","ENSG00000166333","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; PPAR signaling pathway; Eukaryotic transcription initiation; Endometrial cancer; Acute viral myocarditis; Genes controlling nephrogenesis; Development of ureteric collection system","Localization of the PINCH-ILK-PARVIN complex to focal adhesions","PPAR signaling pathway; Axon guidance; Focal adhesion; Bacterial invasion of epithelial cells; Shigellosis; Endometrial cancer",1152.5,1224.5,1234.4,1250.4,1184.9,1204,0.9923336905448848,-0.011102759816445453,0.7878064617485088,0.10358046134077414,0.8834112958972219,0.05383705185771892,6963]
["High","Q13435","Splicing factor 3b subunit 2 [OS=Homo sapiens]",49,43,282,43,895,100.2,5.67,582.83,"RNA metabolism OR transcription;other metabolic processes","nucleus","","SF3B2","ENSG00000087365","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",10928.3,9570.5,10823.6,12136,11089.1,11247.6,0.9086146428913315,-0.1382595393755108,0.12598685888018282,0.8996747518146118,0.29496413617285383,0.5302307854085442,3335]
["High","Q13438-1","Protein os-9 [OS=Homo sapiens]",35,22,48,22,667,75.5,4.87,78.4,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;ER/Golgi","other molecular function","OS9","ENSG00000135506","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",1438.8,1378.6,1423.1,1343.4,1285,1272,1.0871961850066658,0.12061229878083662,0.016259781948103742,1.788885282811464,0.08497749494698395,1.0706960756322086,1494]
["High","Q13464","Rho-associated protein kinase 1 [OS=Homo sapiens]",27,35,47,31,1354,158.1,5.9,89.19,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function","ROCK1","ENSG00000067900","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; G13 signaling pathway","Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse; EPHB-mediated forward signaling; RND3 GTPase cycle; RHOBTB1 GTPase cycle; Potential therapeutics for SARS; VEGFA-VEGFR2 Pathway; Apoptotic cleavage of cellular proteins; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; RHOH GTPase cycle","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; TGF-beta signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer",2208.8,2009.9,2066.7,2247.5,2174.3,2067.3,0.9686088979981817,-0.04601383875880245,0.4383801700485441,0.35814909921636934,0.634100105175812,0.1978421747782317,5398]
["High","Q13492-1","Phosphatidylinositol-binding clathrin assembly protein [OS=Homo sapiens]",18,10,25,9,652,70.7,7.9,40.14,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PICALM","ENSG00000073921","","Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; RND3 GTPase cycle","",873.1,879.4,796.8,862,890.6,867.9,0.972829612669338,-0.03974095019203683,0.443496492761537,0.3531098102862208,0.6380727133742549,0.19512982720706157,5427]
["High","Q13501-1","sequestosome-1 [OS=Homo sapiens]",58,14,59,14,440,47.7,5.22,141.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","SQSTM1","ENSG00000161011","IL-1 signaling pathway; RANKL/RANK signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Interleukin-1 induced activation of NF-kB; Clear cell renal cell carcinoma pathways; CAMKK2 pathway; 7q11.23 copy number variation syndrome","Interleukin-1 signaling; Signaling by ALK fusions and activated point mutants; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; PINK1-PRKN Mediated Mitophagy; NRIF signals cell death from the nucleus; Pexophagy","Mitophagy; Autophagy; Necroptosis; Cellular senescence; Osteoclast differentiation; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Shigellosis; Fluid shear stress and atherosclerosis",2170,2025.8,2073.1,1414.1,1411,1386.8,1.4883781666231393,0.5737411324914305,9.3008662688231941E-5,4.031476600021428,0.008645376646068036,2.063216081424674,84]
["High","Q13555-8","Isoform 8 of Calcium/calmodulin-dependent protein kinase type II subunit gamma [OS=Homo sapiens]",22,9,21,7,556,62.1,7.42,36.99,"protein metabolism;other metabolic processes;other biological processes","other cell component","kinase activity;other molecular function","CAMK2G; LOC111145432","ENSCATG00000041481; ENSECAG00000000031; ENSFCAG00000018407; ENSG00000148660; ENSLCNG00005022562; ENSMPUG00000003376; ENSPANG00000022457; ENSPTRG00000002643","Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway; Calcium regulation in cardiac cells","","ErbB signaling pathway; Calcium signaling pathway; cAMP signaling pathway; HIF-1 signaling pathway; Oocyte meiosis; Necroptosis; Adrenergic signaling in cardiomyocytes; Wnt signaling pathway; Axon guidance; Circadian entrainment; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Dopaminergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Melanogenesis; Oxytocin signaling pathway; Glucagon signaling pathway; Aldosterone synthesis and secretion; Cushing syndrome; Gastric acid secretion; Parkinson disease; Pathways of neurodegeneration; Amphetamine addiction; Tuberculosis; Pathways in cancer; Proteoglycans in cancer; Glioma; Diabetic cardiomyopathy; Lipid and atherosclerosis",841.2,837.5,847.6,761.5,799.2,791.3,1.074107142857143,0.10313791023111012,0.00803138782180603,2.0952094022588033,0.05742589387606363,1.2408922359688863,1092]
["High","Q13573","SNW domain-containing protein 1 [OS=Homo sapiens]",19,10,17,10,536,61.5,9.52,28.8,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SNW1","ENSG00000100603","TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; mRNA Splicing - Major Pathway; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling","Spliceosome; Notch signaling pathway; Epstein-Barr virus infection; Viral carcinogenesis",750.9,581.5,537.1,1244.7,647.7,493.2,0.7836602951039571,-0.35169969153791114,0.5101438888194122,0.2923073115361561,0.693454645526109,0.15898193811176464,5744]
["High","Q13574","Diacylglycerol kinase zeta [OS=Homo sapiens]",13,10,17,10,1117,124.1,9.04,42.38,"","","","","","","","",546,591.1,603.9,626.5,626,621.7,0.9289296766620425,-0.10635871138071874,0.06542405370194895,1.1842625503081647,0.19822701253582362,0.7028371642004341,2577]
["High","Q13615","myotubularin-related protein 3 [OS=Homo sapiens]",4,4,4,4,1198,133.5,5.8,7.86,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;other cell component","other molecular function","MTMR3","ENSG00000100330","","Synthesis of PIPs at the plasma membrane; Macroautophagy","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Autophagy",175.4,183.4,201.8,180,157.3,185.4,1.0725081308590012,0.1009885850726011,0.3383487583864349,0.4706354128761213,0.5398093799512227,0.2677595732332563,4894]
["High","Q13636","ras-related protein rab-31 [OS=Homo sapiens]",17,3,4,3,194,21.6,7.06,11.98,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB31","ENSG00000168461","","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","Endocytosis",288.6,282.5,321,280.2,280.9,245.1,1.1065492433639297,0.1460676550034909,0.16361414799413554,0.7861791448571334,0.348472249737646,0.4578318008246958,3666]
["High","Q13637","Ras-related protein Rab-32 [OS=Homo sapiens]",9,2,2,2,225,25,6.54,5.58,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB32","ENSG00000118508","","RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","",181.9,168.1,162.4,183.5,180.6,177.7,0.945736434108527,-0.080489917860368,0.17921941133479447,0.7466149534962718,0.36747509550999874,0.4347720885500731,3808]
["High","Q13794","phorbol-12-myristate-13-acetate-induced protein 1 [OS=Homo sapiens]",41,2,3,2,54,6,10.29,7.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus","","PMAIP1","ENSG00000141682","miRNA regulation of DNA damage response; TP53 network; Apoptosis modulation and signaling; Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; miRNA regulation of p53 pathway in prostate cancer; Chromosomal and microsatellite instability in colorectal cancer ; Unfolded protein response; p53 transcriptional gene network; DNA damage response; DNA damage response (only ATM dependent)","TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation of NOXA and translocation to mitochondria","Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Pathways in cancer; Viral carcinogenesis; Colorectal cancer",114.6,133,114.2,82.4,74.5,78.4,1.5376115597110072,0.6206910873969435,3.0930724834915416E-3,2.509609902560171,0.033636086282871805,1.4731945421438357,718]
["High","Q13838-1","spliceosome RNA helicase DDX39B [OS=Homo sapiens]",60,24,220,12,428,49,5.67,471.31,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BAT1; DDX39B; LOC101341139","ENSANAG00000030372; ENSCANG00000041217; ENSCCAG00000027897; ENSCJAG00000003152; ENSECAG00000007750; ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439; ENSGGOG00000005989; ENSMFAG00000034233; ENSMICG00000017349; ENSMLEG00000043791; ENSMMUG00000008839; ENSMNEG00000041059; ENSMODG00000015791; ENSOANG00000008361; ENSPANG00000018609; ENSPCOG00000018656; ENSPCTG00005013682; ENSPPAG00000043072; ENSPPYG00000016433; ENSPTRG00000032509; ENSRROG00000039517; ENSSHAG00000003209; ENSSSCG00000001400; ENSSSCG00005031872; ENSSSCG00015055352; ENSSSCG00025077755; ENSSSCG00030066086; ENSSSCG00035021438; ENSSSCG00040071129; ENSSSCG00045038130; ENSSSCG00050005792; ENSSSCG00055028973; ENSSSCG00060042375; ENSSSCG00065025136; ENSSSCG00070024145; ENSVURG00010001931","","Transport of Mature mRNA derived from an Intron-Containing Transcript; RHOBTB2 GTPase cycle; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",8965.3,9402.5,8898.8,8848.6,9755.1,9439.4,0.9723104792266192,-0.040511024557654735,0.4494912456447907,0.3472787622292699,0.6429066946317138,0.1918520518765958,5459]
["High","Q13884","Beta-1-syntrophin [OS=Homo sapiens]",2,1,1,1,538,58,8.63,2.76,"other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SNTB1","ENSG00000172164","IL-18 signaling pathway","","",45.1,40,35.1,42.1,41.1,45.3,0.9354085603112839,-0.09633146337005519,0.4297200664028696,0.3668143658307319,0.6255134747340801,0.20376333035165778,5364]
["High","Q13952-1","Nuclear transcription factor Y subunit gamma [OS=Homo sapiens]",11,5,13,5,458,50.3,6.1,18.92,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFYC","ENSG00000066136","","PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum  stress; ATF6 (ATF6-alpha) activates chaperone genes","Antigen processing and presentation; Tuberculosis",515.5,512.6,521,590.7,533,542.5,0.9297203216900732,-0.10513130468138641,0.09636845874159938,1.0160650868018462,0.2507313981520853,0.6007912775680634,3001]
["High","Q14011","Cold-inducible RNA-binding protein [OS=Homo sapiens]",46,7,37,2,172,18.6,9.51,75.64,"cell organization and biogenesis;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CIRBP","ENSG00000099622","","","",1844.8,1773.3,1897.3,1402.9,1329.4,1408,1.3321256913750208,0.4137302128658924,4.7968550014636962E-4,3.3190434091171643,0.016355390328134736,1.7863390867984168,229]
["High","Q14108-1","Lysosome membrane protein 2 [OS=Homo sapiens]",13,6,21,6,478,54.3,5.14,38.78,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCARB2","ENSG00000138760","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome","Cargo recognition for clathrin-mediated endocytosis","Lysosome",963.4,928,934.6,870.5,874.9,869.5,1.0807296646143256,0.11200569023698113,0.003060276426120239,2.5142393431535157,0.03360708626602929,1.4735691392246468,711]
["High","Q14119","Vascular endothelial zinc finger 1 [OS=Homo sapiens]",11,5,10,3,521,56.9,9.52,26.17,"stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","VEZF1","ENSG00000136451","","","",83.3,76,77.9,75.8,81.5,81.3,0.9941324392288349,-0.008490033149224373,0.8789481493109614,0.056036743961860855,0.9352449100327046,0.029074646723154584,7338]
["High","Q14155-1","Isoform 1 of Rho guanine nucleotide exchange factor 7 [OS=Homo sapiens]",24,15,41,12,646,73.1,7.21,77.89,"","","","ARHGEF7","","","","",1850,1768.8,1935.4,2139,2017.5,2096.7,0.8882172327768184,-0.17101553281395326,0.017640182075497796,1.7534969365525044,0.08937997511063386,1.0487597706122884,1541]
["High","Q14165","Malectin [OS=Homo sapiens]",41,13,56,13,292,32.2,5.41,127.57,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","MLEC","ENSG00000110917","","Neutrophil degranulation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle","",3149.2,3320.8,3185.2,2892.1,3176.5,2971.8,1.0680058404495374,0.09491953650537806,0.10854265288510297,0.9643995680589048,0.2688772315123363,0.570445972217787,3152]
["High","Q14185","Dedicator of cytokinesis protein 1 [OS=Homo sapiens]",9,13,21,13,1865,215.2,7.56,36.41,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DOCK1","ENSG00000150760","Integrin-mediated cell adhesion; Focal adhesion; Hepatocyte growth factor receptor signaling; Regulation of actin cytoskeleton","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; DCC mediated attractive signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases","Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection",657.1,691.4,679.7,627.6,666.2,651.1,1.042829965550928,0.06050394419112754,0.13942759260741558,0.8556512712070243,0.31418488977740283,0.5028147054962145,3465]
["High","Q14197","Peptidyl-tRNA hydrolase ICT1, mitochondrial [OS=Homo sapiens]",17,3,3,3,206,23.6,10.07,2.99,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL58","ENSG00000167862","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",33.1,22.5,27.2,32.2,24.7,23.3,1.0324189526184537,0.04602853104440475,0.8439564702756559,0.07367995290824111,0.9176454699780422,0.03732507497677554,7181]
["High","Q14247-1","Src substrate cortactin [OS=Homo sapiens]",52,29,112,29,550,61.5,5.4,244.18,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CTTN","ENSG00000085733; ENSG00000288401","Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma","Clathrin-mediated endocytosis; RHO GTPases activate PAKs","Tight junction; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Proteoglycans in cancer",5613,5541.9,5929.7,6743.4,5974.3,6198.9,0.9031538437139865,-0.146956336795113,0.07674942635397988,1.1149248618733445,0.21759604973561184,0.6623489931356139,2754]
["High","Q14315","Filamin-C [OS=Homo sapiens]",65,139,716,120,2725,290.8,5.97,1666.9,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","FLNC","ENSG00000128591","Focal adhesion; MAPK signaling pathway; Ebola virus infection in host","Cell-extracellular matrix interactions","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer",34256.9,35344.6,32926.3,16614.4,16484.9,16742.9,2.057048043625682,1.0405754892887564,1.5262733561965607E-5,4.816367677091502,0.005181366245731629,2.285555708450459,23]
["High","Q14332","Frizzled-2 [OS=Homo sapiens]",2,2,2,1,565,63.5,8.1,3.91,"cell-cell signaling;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","FZD2","ENSG00000180340","MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Asymmetric localization of PCP proteins; Ca2+ pathway; Class B/2 (Secretin family receptors); Disassembly of the destruction complex and recruitment of AXIN to the membrane","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",77.6,60.2,61.7,81.8,63.2,80.2,0.885879218472469,-0.17481808097052134,0.35246139392372555,0.45288844554945035,0.5545070650325306,0.25609291608813833,4963]
["High","Q14457","Beclin-1 [OS=Homo sapiens]",18,9,12,9,450,51.9,4.89,21.14,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BECN1","ENSG00000126581","Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; Malignant pleural mesothelioma; Alzheimer's disease","Ub-specific processing proteases; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Autophagy; Mitophagy; Autophagy; Apoptosis; Apelin signaling pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Kaposi sarcoma-associated herpesvirus infection",470.1,486.1,484.9,485.1,478.1,462.6,1.0107308177865055,0.015398823597846896,0.5768059197867024,0.23897029108074588,0.7423274471228897,0.12940448136615879,6067]
["High","Q14527","Helicase-like transcription factor [OS=Homo sapiens]",31,25,42,25,1009,113.9,8.6,87.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HLTF","ENSG00000071794","Retinoblastoma gene in cancer","E3 ubiquitin ligases ubiquitinate target proteins","",1827.4,1865.3,1785.9,2397.4,2379.6,2500.9,0.7527720908503827,-0.4097149539863532,1.7112945371653191E-4,3.766675236012992,0.010952285037858042,1.960495262029105,122]
["High","Q14596-1","Next to BRCA1 gene 1 protein [OS=Homo sapiens]",7,4,6,4,966,107.3,5.12,13.95,"other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NBR1","ENSG00000188554","","Pexophagy","Mitophagy",166.5,164.4,169.2,197,178.4,181,0.8988138030194104,-0.1539058148346663,0.03488828761716758,1.45732034601951,0.13498897409060676,0.8697017032617664,2018]
["High","Q14657","EKC/KEOPS complex subunit LAGE3 [OS=Homo sapiens]",21,2,5,2,143,14.8,8.63,9.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","LAGE3","ENSG00000196976","","tRNA modification in the nucleus and cytosol","",133.9,146.5,109,138.8,92.7,104.1,1.1603098927294395,0.2145101682804711,0.3684710541470716,0.43359662318608755,0.5707244576037165,0.24357351596560275,5041]
["High","Q14671-3","Isoform 3 of Pumilio homolog 1 [OS=Homo sapiens]",21,22,57,1,1188,126.6,6.84,117.66,"","","","PUM1","","","","",12.1,11.2,12.1,11.2,18.2,9.1,0.9194805194805193,-0.1211090854992665,0.7277889891459255,0.1379945192215324,0.848272343223076,0.07146469235399744,6699]
["High","Q14681","BTB/POZ domain-containing protein KCTD2 [OS=Homo sapiens]",24,3,6,2,263,28.5,5.29,11.77,"cell organization and biogenesis;protein metabolism;other metabolic processes","other cell component","other molecular function","KCTD2","ENSG00000180901","","","",21.4,26.8,24.6,24.8,15.2,19.8,1.2173913043478262,0.28379296600059134,0.24523739136966685,0.6104133121818303,0.4433465042404165,0.3532567115706934,4319]
["High","Q14691","DNA replication complex GINS protein PSF1 [OS=Homo sapiens]",40,6,16,6,196,23,7.39,36.45,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;developmental processes","nucleus;other cell component","","GINS1","ENSG00000101003","","Unwinding of DNA","",581.2,581.2,591.8,612.4,603.1,569.7,0.9826349988796773,-0.025272469872390516,0.4847796906792174,0.31445558275823354,0.6735159830646493,0.17165209366865924,5620]
["High","Q14697-2","Isoform 2 of Neutral alpha-glucosidase AB [OS=Homo sapiens]",61,47,354,1,966,109.4,6.24,762.7,"","","","GANAB","","","","",705.7,680.1,733.9,766.9,703,740.2,0.9590968734446403,-0.060251553074844734,0.2807062309990868,0.5517479469719534,0.4810698533013323,0.3177918577203807,4556]
["High","Q14739","Lamin-B receptor [OS=Homo sapiens]",24,17,59,17,615,70.7,9.36,103.64,"other metabolic processes;developmental processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","LBR","ENSG00000143815","Gastric cancer network 2; ATM signaling in development and disease ; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias","RHOC GTPase cycle; RHOA GTPase cycle; RHOD GTPase cycle; Regulation of MECP2 expression and activity; CDC42 GTPase cycle; RAC1 GTPase cycle; Cholesterol biosynthesis; Initiation of Nuclear Envelope (NE) Reformation; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","Steroid biosynthesis; Metabolic pathways",3363.2,3404.1,3435.1,3558.2,3516.3,3486.3,0.966063177032043,-0.049810555711946446,0.015420179318892425,1.8119105759119964,0.08280657504945808,1.0819351777763802,1454]
["High","Q14790-4","Isoform 4 of Caspase-8 [OS=Homo sapiens]",20,6,8,6,496,57.7,5.43,17.84,"","","","CASP8","","","","",255,276.4,290.5,324.8,318.5,326.5,0.8474943287275727,-0.23872438084956932,0.009663939048229103,2.0148458178683533,0.06400003060947652,1.193819818304807,1179]
["High","Q14894","Ketimine reductase mu-crystallin [OS=Homo sapiens]",26,6,9,6,314,33.8,5.14,14.17,"other metabolic processes;transport;other biological processes","cytosol;other cytoplasmic organelle;other cell component","other molecular function","CRYM","ENSG00000103316","","Lysine catabolism","",367.1,377.6,350.3,304.7,341.1,345.9,1.1041645658969446,0.1429552089910755,0.0868044922286946,1.0614577990210803,0.2344411882814415,0.6299660860331029,2891]
["High","Q14974","Importin subunit beta-1 [OS=Homo sapiens]",54,37,300,37,876,97.1,4.78,636.72,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","KPNB1","ENSG00000108424","Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome","Neutrophil degranulation; Assembly of the ORC complex at the origin of replication; Apoptosis induced DNA fragmentation; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Regulation of cholesterol biosynthesis by SREBP (SREBF); Initiation of Nuclear Envelope (NE) Reformation; Postmitotic nuclear pore complex (NPC) reformation; Inhibition of nitric oxide production","Nucleocytoplasmic transport; Chemical carcinogenesis",10476.8,10809.3,10566.5,10389.1,10714.7,10753.1,0.9998650213925396,-1.9474611118431529E-4,0.992941903234758,0.003076161215272647,0.9977979897628044,0.000957375357551493,7770]
["High","Q14BN4","Sarcolemmal membrane-associated protein [OS=Homo sapiens]",22,18,27,18,828,95.1,5.47,58.18,"other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","SLMAP","ENSG00000163681","","","",906.5,930.4,992.6,1016.9,995.4,1015,0.9346612492980543,-0.09748451331999701,0.06807275618136047,1.1670266649951777,0.20286720620765747,0.6927881516562877,2620]
["High","Q15006","ER membrane protein complex subunit 2 [OS=Homo sapiens]",34,9,37,9,297,34.8,6.57,77.06,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC2","ENSG00000104412","","","",828.7,866.7,879.4,829.8,855.8,843.3,1.018150183874412,0.02595038415423376,0.4185254027629716,0.3782781769897893,0.6154136242510889,0.210832893412623,5310]
["High","Q15007","Pre-mRNA-splicing regulator WTAP [OS=Homo sapiens]",32,10,23,10,396,44.2,5.19,66.49,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","WTAP","ENSG00000146457","","Processing of Capped Intron-Containing Pre-mRNA","",923.8,824,824.1,826.8,816.9,835.4,1.0374329393731596,0.05301808232881017,0.41031523987426094,0.3868823522254309,0.6078052348583247,0.21623556378175288,5271]
["High","Q15022","Polycomb protein suz12 [OS=Homo sapiens]",13,7,11,7,739,83,8.81,21.89,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","SUZ12","ENSG00000178691","Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma","HCMV Early Events; Defective pyroptosis; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines","",386.4,375.1,330.4,382.3,412.4,392.3,0.9198820556023589,-0.1204791997021263,0.1749966533183236,0.7569702567953209,0.3623372763483083,0.44088698454230574,3771]
["Medium","Q15035","Translocating chain-associated membrane protein 2 [OS=Homo sapiens]",2,1,1,1,370,43.3,9.22,1.96,"cell organization and biogenesis;other metabolic processes;transport","other membranes;ER/Golgi","","TRAM2","ENSG00000065308","","","",59.9,48.2,55.2,54.5,56,60.8,0.9532983070636311,-0.06900036052230403,0.5310977098602305,0.27482557129261026,0.7101919709862442,0.14862424188526216,5839]
["High","Q15047","Histone-lysine N-methyltransferase SETDB1 [OS=Homo sapiens]",16,19,52,19,1291,143.1,6.02,98.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETDB1","ENSG00000143379","Histone modifications; Malignant pleural mesothelioma","PKMTs methylate histone lysines","Lysine degradation; Metabolic pathways; Signaling pathways regulating pluripotency of stem cells",1990.4,1924.5,1887,2292.7,2356.4,2292.2,0.835852073819025,-0.2586804531207785,5.0699383554032688E-4,3.294997321154032,0.01670298678438343,1.7772058625055005,237]
["High","Q15054","DNA polymerase delta subunit 3 [OS=Homo sapiens]",23,11,24,11,466,51.4,9.35,42.02,"DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","POLD3","ENSG00000077514","Homologous recombination; Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Dual Incision in GG-NER; Termination of translesion DNA synthesis; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)","DNA replication; Base excision repair; Nucleotide excision repair; Mismatch repair; Homologous recombination",936.3,963.8,965.8,1108.4,1118.9,1090.8,0.8637171875470899,-0.21136909605768947,2.7643859083200761E-4,3.5584013295485435,0.013406413150411897,1.8726874009217578,161]
["High","Q15070-1","Mitochondrial inner membrane protein OXA1L [OS=Homo sapiens]",11,5,7,5,435,48.5,9.45,14.77,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;other cell component","translation activity;other molecular function","OXA1L","ENSG00000155463","","Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination","Protein export",519.6,519.3,469.9,611.4,585.6,572.7,0.8525738825789683,-0.2301032338746598,0.012289403539426374,1.9104691948858714,0.07274879669131246,1.1381741857736012,1319]
["Medium","Q15121","Astrocytic phosphoprotein PEA-15 [OS=Homo sapiens]",8,1,1,1,130,15,5.02,2.31,"transport;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus","","PEA15","ENSG00000162734","Apoptosis modulation and signaling","RAF/MAP kinase cascade; RAF-independent MAPK1/3 activation","",99.7,110.4,100.7,104.5,87.7,95.5,1.08029197080292,0.11142128266842338,0.2641444584922555,0.5781584959801813,0.46305341982656734,0.3343689040195653,4454]
["High","Q15149-3","Isoform 3 of Plectin [OS=Homo sapiens]",41,185,463,1,4570,517.7,5.74,980.82,"","","","PLEC","","","","",10.7,15.2,11.3,14,14.6,13.8,0.8773584905660377,-0.18876164345516794,0.29245729287918676,0.5339375443546941,0.4930914581733298,0.30707252068995206,4631]
["High","Q15172-1","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [OS=Homo sapiens]",5,2,2,2,486,56.2,6.71,3.11,"protein metabolism;other metabolic processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP2R5A","ENSG00000066027; ENSGGOG00000014986; ENSNLEG00000002787; ENSPPAG00000015631; ENSPPYG00000000237; ENSPTRG00000001958","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; Glycogen metabolism","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Separation of Sister Chromatids; RAF activation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; Dopaminergic synapse; Human papillomavirus infection",79.3,61.7,64.8,64.7,81.3,66.5,0.9684705882352943,-0.04621985901845767,0.7822439741264421,0.1066577736770898,0.8799540339978763,0.05554001342081378,6941]
["High","Q15233","Non-POU domain-containing octamer-binding protein [OS=Homo sapiens]",58,27,490,25,471,54.2,8.95,715.13,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","NONO","ENSG00000147140","mRNA processing","","",12882.6,12577.7,12657.5,13086.9,13434.7,13453.3,0.9535433484511533,-0.06862956938134646,0.014564536428316543,1.836703333887536,0.07991560114708052,1.097368429313185,1423]
["High","Q15283-1","ras GTPase-activating protein 2 [OS=Homo sapiens]",8,6,6,6,850,96.6,7.2,14.19,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;other molecular function","RASA2","ENSG00000155903","MAPK signaling pathway; Ebola virus infection in host; Ras signaling; Modulators of TCR signaling and T cell activation","Regulation of RAS by GAPs","MAPK signaling pathway; Ras signaling pathway; Viral carcinogenesis",352.5,351.3,347.1,358,383.1,339.9,0.9721554116558743,-0.04074112909879338,0.4714868810461068,0.32653038684722274,0.6619977642884377,0.17914347726548768,5561]
["High","Q15365","Poly(RC)-binding protein 1 [OS=Homo sapiens]",84,18,347,12,356,37.5,7.09,948.55,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCBP1","ENSG00000169564","Ferroptosis","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Spliceosome; Ferroptosis",9502.9,9638.2,9592.8,10058.1,9812.8,10007,0.9617108297437233,-0.05632492979910823,0.01077761869914424,1.9674771853518775,0.06841597301050262,1.1648424921326401,1230]
["High","Q15366-1","Poly(rC)-binding protein 2 [OS=Homo sapiens]",65,16,384,1,365,38.6,6.79,990.65,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101348589; Pcbp2; PCBP2","ENSBIXG00000004442; ENSCAFG00000006821; ENSG00000197111; ENSRNOG00000036852","mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation","mRNA Splicing - Major Pathway; Negative regulators of DDX58/IFIH1 signaling; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway","Ferroptosis",347.4,336,367.1,319.2,315.2,316.4,1.1048590660496425,0.14386235361797367,0.022203003239200703,1.6535882777116233,0.10233828175423794,0.9899618790476761,1694]
["High","Q15390","Mitochondrial fission regulator 1 [OS=Homo sapiens]",9,3,6,3,333,37,9.01,10.91,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;mitochondrion","","MTFR1","ENSG00000066855","","","",261.7,266.1,289.3,299.5,283.8,282.1,0.9441876588860642,-0.08285446873451724,0.18949293968779743,0.7224069667605639,0.37966663409862006,0.4205975678946188,3897]
["High","Q15427","Splicing factor 3b subunit 4 [OS=Homo sapiens]",27,8,35,8,424,44.4,8.56,70.93,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","SF3B4","ENSG00000143368","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",1054.3,1034.4,1110.8,1097.1,1064.2,1072.6,0.9893626890132657,-0.015428601485945506,0.6693219879317813,0.17436490773131513,0.809740638638263,0.09165406414056584,6454]
["High","Q15438-1","Cytohesin-1 [OS=Homo sapiens]",14,3,3,2,398,46.4,5.54,9.12,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CYTH1","ENSCATG00000038229; ENSG00000108669; ENSMFAG00000037544; ENSMMUG00000013313; ENSPANG00000019854; ENSPTRG00000009717","","Intra-Golgi traffic","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection",20.2,13.1,22.3,19.7,23.9,17,0.9174917491749174,-0.12423291074944366,0.6526222864376736,0.18533809954655214,0.7979446934709294,0.09802720909134284,6386]
["High","Q15542","Transcription initiation factor TFIID subunit 5 [OS=Homo sapiens]",24,11,28,11,800,86.8,5.64,63.38,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","TAF5","ENSG00000148835","Eukaryotic transcription initiation","Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors",600.9,576.5,588.6,631.1,647,632,0.9245589236165647,-0.11316282706916433,0.005319727893794553,2.2741105814729585,0.045444677674778854,1.3425169725481545,914]
["High","Q15560","transcription elongation factor A protein 2 [OS=Homo sapiens]",25,6,17,4,299,33.6,9.13,31.02,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","TCEA2","ENSG00000171703","","","",146.9,115.7,134.3,127.4,124,131.7,1.0360219263899766,0.05105453657595307,0.647892478697686,0.18849706169543826,0.7945255966187422,0.09989210690064465,6367]
["Medium","Q15573-1","TATA box-binding protein-associated factor RNA polymerase I subunit A [OS=Homo sapiens]",2,1,1,1,450,52.6,9.1,2.59,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus","nucleic acid binding activity","TAF1A","ENSG00000143498","","RNA Polymerase I Transcription Initiation; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; SIRT1 negatively regulates rRNA expression; RNA Polymerase I Transcription Termination","",21.1,25.7,18.3,30,18.3,29,0.8421733505821475,-0.2478108707592119,0.3999591364643667,0.3979843779585251,0.5985970744707255,0.22286541002226462,5217]
["High","Q15637-5","Isoform 5 of Splicing factor 1 [OS=Homo sapiens]",25,13,62,13,673,71.7,9.58,126.09,"","","","SF1","","","","",3043.2,2630.9,2917.1,3328.5,2928.4,3061.9,0.9219212774176934,-0.11728453027171902,0.2255749072457904,0.646709212537936,0.42136097506582093,0.37534568965433585,4180]
["High","Q15678","Tyrosine-protein phosphatase non-receptor type 14 [OS=Homo sapiens]",9,7,12,7,1187,135.2,8.31,17.6,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN14","ENSG00000152104","VEGFA-VEGFR2 signaling pathway","Interleukin-37 signaling","",227.2,255.6,241.8,218.8,241.1,215,1.0736405393391613,0.10251105205999018,0.22493276534907103,0.647947277450807,0.42046325876120344,0.3762719480572927,4177]
["High","Q15723-1","Isoform 1 of ETS-related transcription factor Elf-2 [OS=Homo sapiens]",3,1,1,1,581,62.7,6.7,2.61,"","","","ELF2","","","","",27.3,25.3,28.1,38.2,33.8,27.8,0.808617234468938,-0.30647114205948006,0.11144087721032452,0.9529554780081417,0.272939262628047,0.563933986073581,3188]
["High","Q15751","Probable E3 ubiquitin-protein ligase HERC1 [OS=Homo sapiens]",3,10,12,10,4861,531.9,6.04,18.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","HERC1","ENSG00000103657","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",276.8,273.1,299.2,277.6,274.2,275.8,1.0259787336877721,0.03700082731810525,0.4321070395577194,0.3644086584372787,0.6281682675231192,0.2019240061541431,5371]
["High","Q15800","Methylsterol monooxygenase 1 [OS=Homo sapiens]",9,2,7,2,293,35.2,7.23,14.11,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","MSMO1","ENSG00000052802","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Cholesterol biosynthesis","Steroid biosynthesis; Metabolic pathways",384.1,358.1,366.4,369.6,429,424.7,0.9062372271724025,-0.14203933858265444,0.1370850993401054,0.8630097489016498,0.31042936648710645,0.5080372013956896,3448]
["High","Q15811-7","Isoform 7 of Intersectin-1 [OS=Homo sapiens]",33,30,62,29,1215,137,7.33,118.38,"","","","ITSN1","","","","",2035.3,1973.3,2096.5,2437.7,2291,2309.8,0.8673865170135684,-0.205253077313328,5.9069534138779375E-3,2.228636454260812,0.048345379722808106,1.3156450243062716,954]
["High","Q15942","Zyxin [OS=Homo sapiens]",35,12,44,12,572,61.2,6.67,85.33,"cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","ZYX","ENSG00000159840; ENSG00000285443","Integrin-mediated cell adhesion; Focal adhesion","","Focal adhesion",1007.1,866.1,918.7,1042.3,771.7,700.1,1.1104967980589475,0.1512052331089933,0.45493837994686714,0.3420474232579079,0.6467878497132444,0.18923814716399,5492]
["High","Q16143","Beta-synuclein [OS=Homo sapiens]",30,4,13,1,134,14.3,4.41,31.63,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","cytosol;other cell component","enzyme regulator activity;other molecular function","SNCB","ENSG00000074317","","MTF1 activates gene expression","",208.9,183.7,199,208.8,187.4,185.1,1.0177189059005678,0.025339143867181883,0.760512735120613,0.11889350909776705,0.8676334651989693,0.06166370530819434,6844]
["High","Q16513","Serine/threonine-protein kinase N2 [OS=Homo sapiens]",18,14,30,10,984,112,6.3,68.68,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","PKN2","ENSG00000065243","PI3K-Akt signaling pathway","RAC1 GTPase cycle; RHO GTPases activate PKNs; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle","PI3K-Akt signaling pathway; NOD-like receptor signaling pathway; Yersinia infection",429,424,439,449.1,465.6,483.5,0.9240452009726792,-0.11396467005971753,0.03116054317551413,1.5063949805221801,0.1254778345097547,0.9014329849422501,1939]
["High","Q16539-2","Isoform CSBP1 of Mitogen-activated protein kinase 14 [OS=Homo sapiens]",28,8,23,1,360,41.5,5.88,39.57,"","","","MAPK14","","","","",20,17.1,23.2,17.4,19.8,21.7,1.023769100169779,0.03389036806962378,0.8392746469144411,0.07609589599980202,0.9143374414829015,0.038893495810707,7167]
["High","Q16566","calcium/calmodulin-dependent protein kinase type IV [OS=Homo sapiens]",7,3,5,3,473,51.9,5.82,11.99,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","CAMK4","ENSG00000152495","Energy metabolism; Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway; Common pathways underlying drug addiction; Mitochondrial gene expression; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; CAMKK2 pathway; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells","Transcriptional activation of mitochondrial biogenesis; Regulation of MECP2 expression and activity; Negative regulation of NMDA receptor-mediated neuronal transmission; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; Loss of phosphorylation of MECP2 at T308","Calcium signaling pathway; cAMP signaling pathway; Longevity regulating pathway; Apelin signaling pathway; Osteoclast differentiation; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Oxytocin signaling pathway; Aldosterone synthesis and secretion; Amphetamine addiction; Alcoholism; Glioma",205,191,186.9,204.2,204.8,203.2,0.9521398235870628,-0.0707546432204911,0.15038054154789368,0.8228083555335425,0.33093891443234325,0.4802521620345959,3548]
["High","Q16629","serine/arginine-rich splicing factor 7 [OS=Homo sapiens]",35,12,87,11,238,27.4,11.82,155.06,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","other molecular function","SRSF7","ENSG00000115875","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection",3487.3,3428.8,3581.2,3881,3677.7,3889.8,0.9169148796785606,-0.1251402851297779,0.018247913864393738,1.7387867777262995,0.09075140856890847,1.0421466254768978,1570]
["High","Q16658","Fascin [OS=Homo sapiens]",68,33,275,33,493,54.5,7.24,687.19,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","FSCN1","ENSG00000075618","VEGFA-VEGFR2 signaling pathway","Interleukin-4 and Interleukin-13 signaling","MicroRNAs in cancer",9331.9,9659.5,9167.2,7902.8,8825.2,8387.5,1.1211642212976052,0.1649976107922479,0.02867144648906452,1.542550396123204,0.11990715275126716,0.921154909413647,1867]
["High","Q16698","2,4-dienoyl-CoA reductase, mitochondrial [OS=Homo sapiens]",26,6,11,6,335,36,9.28,28.23,"other metabolic processes;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","DECR1","ENSG00000104325","Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway","mitochondrial fatty acid beta-oxidation of unsaturated fatty acids","",248.4,238.7,241,242.8,245.2,245.4,0.9927733842377966,-0.010463656839375933,0.5926932451591532,0.22717002232538658,0.7545652793417036,0.12230318235424419,6133]
["High","Q16774-1","guanylate kinase [OS=Homo sapiens]",21,4,11,4,197,21.7,6.55,26.05,"other metabolic processes;transport","cytosol;other cell component","kinase activity;other molecular function","GUK1","ENSG00000143774","","Interconversion of nucleotide di- and triphosphates; Abacavir metabolism","Purine metabolism; Metabolic pathways",776.8,748.7,758.4,663.7,643.8,613.6,1.1888501379418042,0.2495668657356953,1.9446477304357606E-3,2.711159058905819,0.02875721492280761,1.541253176780996,528]
["High","Q16799-1","Reticulon-1 [OS=Homo sapiens]",4,2,2,1,776,83.6,4.69,6.67,"developmental processes;other biological processes","other membranes;ER/Golgi","","RTN1","ENSG00000139970","","","",18.7,16.6,20.6,19.2,11,18.6,1.1454918032786885,0.1959671352803038,0.45748508188218173,0.339623063262849,0.6491083989344131,0.18768277141537013,5503]
["Medium","Q16854","Deoxyguanosine kinase, mitochondrial [OS=Homo sapiens]",3,1,1,1,277,32,8.66,2.25,"protein metabolism;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","DGUOK","ENSG00000114956","","Purine salvage","Purine metabolism; Metabolic pathways",83,108.5,76.8,80.7,111.7,94.4,0.9354951185495118,-0.09619796944138366,0.6649461611255943,0.17721351691137066,0.8069474084657509,0.09315476881868624,6434]
["High","Q1KMD3","heterogeneous nuclear ribonucleoprotein U-like protein 2 [OS=Homo sapiens]",55,37,154,37,747,85.1,4.91,356.2,"","nucleus","","HNRNPUL2","ENSG00000214753","","","",5731.8,5570.4,5693.9,5752.4,5765.3,6086.7,0.9654461384653834,-0.05073232036852606,0.16555748848693375,0.7810511704842464,0.3499385138348616,0.45600825692983366,3694]
["High","Q2M1P5","Kinesin-like protein KIF7 [OS=Homo sapiens]",16,16,22,15,1343,150.5,6.79,36.2,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF7","ENSG00000166813","Hedgehog signaling pathway; Hedgehog signaling pathway; Ciliopathies","Hedgehog 'on' state; Hedgehog 'off' state","Hedgehog signaling pathway; Pathways in cancer; Basal cell carcinoma",725.8,660.2,692.8,743.2,633,700.9,1.000818448798806,1.1802890860253467E-3,0.9885963425902069,0.00498100058759222,0.9949678065151245,2.1909711929944645E-3,7758]
["High","Q2NKX8","Dna excision repair protein ercc-6-like [OS=Homo sapiens]",28,28,42,28,1250,141,5.31,93.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","ERCC6L","ENSG00000186871","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",1826.5,1864.1,1938,1774.6,1726.6,1788.9,1.0639874482523959,0.08948113161839424,0.04048612839504324,1.392693751931549,0.14785579537347876,0.8301616481456727,2138]
["Low","Q2TAK8-1","PWWP domain-containing protein MUM1 [OS=Homo sapiens]",2,1,1,1,710,78.6,8.54,0,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","other molecular function","PWWP3A","ENSG00000160953","IL-18 signaling pathway","","",33.5,31.2,35.2,55.8,49.9,66.3,0.5808139534883722,-0.7838519817970417,0.008214028758298311,2.085443780962717,0.058304669586175646,1.2342966614623065,1100]
["High","Q2TAZ0-1","Autophagy-related protein 2 homolog A [OS=Homo sapiens]",9,11,13,11,1938,212.7,5.88,25.74,"cell organization and biogenesis;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ATG2A","ENSG00000110046","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease","","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",267.4,269.5,280.2,260.8,234.5,235.3,1.1183958390364082,0.16143089832535554,0.03861650759396911,1.4132270055760692,0.14357985299700515,0.8429064956513531,2100]
["High","Q32P28-1","Prolyl 3-hydroxylase 1 [OS=Homo sapiens]",42,25,107,23,736,83.3,5.14,239.1,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","P3H1","ENSG00000117385","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",4050.6,4091.2,4423,4172.7,4011.6,4092.9,{"$f":"AVERAGE(T3522:V3522)/AVERAGE(W3522:Y3522)","v":1.023425536767341},{"$f":"LOG(Z3522,2)","v":0.033406137393518574},{"$f":"TTEST(T3522:V3522,W3522:Y3522,2,2)","v":0.49166468286221565},{"$f":"-LOG10(AB3522)","v":0.30833098672493364},{"$f":"AB3522*7808/AF3522","v":0.6788537301128523},{"$f":"-LOG10(AD3522)","v":0.1682237913277723},5655]
["Low","Q3C1V8","Brain-specific homeobox protein homolog [OS=Homo sapiens]",6,1,1,1,233,25.9,7.5,0,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BSX","ENSG00000188909","","","",164.4,184.4,139.7,150.3,165.4,158.8,1.0295047418335088,0.04195047494727566,0.7495834678015325,0.1251800004577167,0.8619657903673587,0.06450997007958303,6790]
["High","Q3KR37","GRAM domain-containing protein 1B [OS=Homo sapiens]",3,2,2,2,738,85.3,6.21,2.16,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","GRAMD1B","ENSG00000023171","Ectoderm differentiation","","",30.8,32.3,38.8,32.9,32.7,36.3,1,0,1,0,1.000640779187492,-2.7819774310026068E-4,7803]
["High","Q3T8J9-1","GON-4-like protein [OS=Homo sapiens]",7,9,10,8,2241,248.5,5.01,14.2,"developmental processes;other biological processes","nucleus","other molecular function","GON4L","ENSG00000116580","","","",253.8,257.3,245.7,248.1,226.2,252,1.0419936665289824,0.05934650861930235,0.3090752947016622,0.5099357079860181,0.5093414734129545,0.2929909597141288,4738]
["High","Q3YEC7-1","Rab-like protein 6 [OS=Homo sapiens]",24,15,40,15,729,79.5,5.22,51.27,"","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RABL6","ENSG00000196642","","","",1179.3,1177.4,1189.8,1255.3,1166.6,1204.4,0.977994098668064,-0.032102335075912,0.36387735196330323,0.4390449744315028,0.5654038535581037,0.24764123586539394,5025]
["High","Q49A26-5","Isoform 5 of Putative oxidoreductase GLYR1 [OS=Homo sapiens]",39,11,34,2,472,51.5,8.27,60.96,"","","","","","","","",27,26.7,43.3,40.3,30.9,31.8,0.9417475728155342,-0.08658768499609033,0.7649275482937394,0.11637969800499771,0.8700006259399152,0.06048043491913619,6865]
["High","Q4G0N4","NAD kinase 2, mitochondrial [OS=Homo sapiens]",6,2,4,2,442,49.4,8.18,10.44,"other metabolic processes","mitochondrion","kinase activity;other molecular function","NADK2","ENSG00000152620","","Nicotinate metabolism","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors",160.7,179.9,152.5,154.9,192.2,188.5,0.9206497386109037,-0.11927570782319145,0.380228748820439,0.4199550495377563,0.5808699023263525,0.23592112583435787,5111]
["High","Q4G148-1","Glucoside xylosyltransferase 1 [OS=Homo sapiens]",13,5,12,5,440,50.5,8.65,15.35,"protein metabolism;other metabolic processes","other membranes","other molecular function","GXYLT1","ENSG00000151233","","","Other types of O-glycan biosynthesis",504,485.5,497.9,491,478,484.5,1.0233230134158926,0.03326160578427868,0.16258423295608262,0.7889215735770542,0.3470360007985493,0.45962547005881677,3658]
["High","Q4V328","GRIP1-associated protein 1 [OS=Homo sapiens]",57,35,105,35,841,95.9,5.11,236.5,"","","","","","","","",3558.5,3170.9,3418.2,3603.2,3139.5,3251.5,1.0153489023633706,0.02197556309047487,0.7903006977141918,0.10220763464524998,0.8840498349215486,0.05352325260977565,6980]
["High","Q4ZIN3-1","Membralin [OS=Homo sapiens]",4,3,5,3,620,67.8,5.3,7.84,"stress response;other biological processes","other membranes;ER/Golgi","","TMEM259","ENSG00000182087","","","",310,319.6,286,268,235.4,243.5,1.225866916588566,0.29380236467365756,0.015891361882489016,1.7988388823580443,0.08417893729882919,1.0747965612224417,1474]
["High","Q53EP0","Fibronectin type III domain-containing protein 3B [OS=Homo sapiens]",6,5,8,5,1204,132.8,5.95,11.71,"","other membranes","","FNDC3B","ENSG00000075420","","","",132.4,125.3,127.9,131.4,125.6,112,{"$f":"AVERAGE(T3586:V3586)/AVERAGE(W3586:Y3586)","v":1.0449864498644987},{"$f":"LOG(Z3586,2)","v":0.06348423528220334},{"$f":"TTEST(T3586:V3586,W3586:Y3586,2,2)","v":0.41648217113563457},{"$f":"-LOG10(AB3586)","v":0.3804035852371257},{"$f":"AB3586*7808/AF3586","v":0.6142600665332517},{"$f":"-LOG10(AD3586)","v":0.21164771754381975},5294]
["High","Q53G59-1","Kelch-like protein 12 [OS=Homo sapiens]",20,8,12,7,568,63.2,5.44,18.03,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","KLHL12","ENSCANG00000030198; ENSCATG00000031800; ENSG00000117153; ENSGGOG00000009159; ENSMLEG00000023751; ENSMMUG00000017849; ENSMNEG00000042480; ENSPPAG00000041960; ENSPTRG00000001861; ENSRBIG00000033303; ENSRROG00000044766","","Degradation of DVL","",366,381.3,340.6,354.1,358.2,353,1.0212146813104293,0.030286183654280645,0.5634007100731113,0.2491826099937675,0.7345187417349897,0.1339971184193409,5989]
["Medium","Q53HI1","protein unc-50 homolog [OS=Homo sapiens]",2,1,2,1,259,30.4,9.47,4.67,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity","UNC50","ENSG00000115446","","","",173.1,176,167.7,227.7,240.7,231.9,0.7379694416678566,-0.43836701744587414,1.7516705252038081E-4,3.7565475777010477,0.011119547529098646,1.95391288448181,123]
["High","Q53HV7-1","single-strand selective monofunctional uracil DNA glycosylase [OS=Homo sapiens]",8,2,3,2,270,29.8,6.62,7.09,"DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","nucleic acid binding activity;other molecular function","SMUG1","ENSG00000123415; ENSPPAG00000033677","Fluoropyrimidine activity; Base excision repair; DNA repair pathways, full network","Displacement of DNA glycosylase by APEX1; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine","Base excision repair",123.1,113.1,115.3,114.9,121.9,127.4,0.9651290499725425,-0.05120623301694079,0.4205669108930063,0.37616489946205406,0.617021127443178,0.20969996501878863,5322]
["High","Q587I9","vesicle transport protein SFT2C [OS=Homo sapiens]",27,4,12,4,215,21.8,9.89,39.1,"transport","other membranes","","SFT2D3","ENSG00000173349","","","",367.9,341.8,348.2,328.7,363.7,335,1.0296865875024335,0.04220528161988466,0.4881604849433983,0.31143737826906964,0.6768881311379957,0.16948310095144298,5631]
["High","Q587J7-1","Putative ATP-dependent RNA helicase TDRD12 [OS=Homo sapiens]",15,15,33,15,1177,132.5,6.74,54.58,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","other cell component","nucleic acid binding activity;other molecular function","TDRD12","ENSG00000173809","","PIWI-interacting RNA (piRNA) biogenesis","",1093.3,1122.9,1013.8,1250.8,1449.6,1321.7,0.8030630765023248,-0.3164147863686726,0.016672696676242448,1.7779941508082135,0.08626932779860905,1.0641435859251678,1509]
["High","Q5BJF2","sigma intracellular receptor 2 [OS=Homo sapiens]",10,2,10,2,176,20.8,9.38,9.4,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","","TMEM97","ENSG00000109084","","","",347.7,366.7,387.6,359.7,398.9,376.4,0.9709251101321585,-0.04256807360711979,0.5338812348185342,0.2725553437196986,0.7120848448006688,0.14746825715883635,5854]
["High","Q5EBL4-1","RILP-like protein 1 [OS=Homo sapiens]",42,12,26,12,403,47.1,5.21,59.7,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RILPL1","ENSG00000188026; ENSGGOG00000014925","","","",926.1,930.5,940.3,1123.2,1098.7,1099.6,0.8420593105524611,-0.24800624161187307,4.233288611891475E-5,4.373322121727016,0.006886149475343466,2.162023554443967,48]
["High","Q5EBM0-1","UMP-CMP kinase 2, mitochondrial [OS=Homo sapiens]",3,1,1,1,449,49.4,7.01,3.06,"other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","kinase activity;other molecular function","CMPK2","ENSG00000134326","Pyrimidine metabolism","","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",87.8,96.8,94.3,82.1,101.3,92.4,1.0112400290065264,0.016125477514331674,0.8749583875547386,0.05801260124636815,0.9331614656505121,0.03004320344116305,7321]
["High","Q5HYJ3-1","Protein FAM76B [OS=Homo sapiens]",17,6,9,4,339,38.7,9.25,11.8,"","nucleus","","FAM76B","ENSG00000077458","","","",238.7,212.7,243.7,202,208,199.1,1.1411919225086191,0.1905414405023019,0.04509531915861327,1.3458685350418997,0.15817801077738206,0.8008538903819539,2226]
["High","Q5JPI3","Uncharacterized protein C3orf38 [OS=Homo sapiens]",19,5,10,5,329,37.5,6.47,16.16,"other biological processes","nucleus","","C3orf38","ENSG00000179021","","","",350.3,334.4,359.6,344,333.1,348.9,1.0178362573099418,0.025505488950422657,0.5224860729782513,0.2819252813112728,0.7028896033449666,0.15311288041833568,5804]
["High","Q5JRA6-1","Transport and Golgi organization protein 1 homolog [OS=Homo sapiens]",41,65,167,64,1907,213.6,4.84,369.78,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MIA3","ENSG00000154305","Type I collagen synthesis in the context of osteogenesis imperfecta","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER","",7681,6472.8,7561.6,6796.2,6426.3,6964.8,1.0756961059676136,0.10527056085234993,0.28794865517872004,0.5406849454369916,0.48876154339901,0.3109029724599303,4600]
["High","Q5JTV8-3","Isoform 3 of Torsin-1A-interacting protein 1 [OS=Homo sapiens]",28,14,38,1,584,66.3,8.18,78.04,"","","","TOR1AIP1","","","","",19.3,20.9,22.2,21.6,18.4,15.8,1.1182795698924732,0.16128090703306094,0.3058230300685626,0.5145298130535545,0.5057966995923187,0.296024008826174,4721]
["High","Q5M775-1","Cytospin-B [OS=Homo sapiens]",16,16,23,16,1068,118.5,6.7,44.06,"cell organization and biogenesis","other membranes;cytosol;cytoskeleton;nucleus;other cell component","","SPECC1","ENSG00000128487","","","",1082.7,1027.4,1135.2,1202,962.1,1054.1,1.0084208563793424,0.01209786175007449,0.9116880250639849,0.04015374957989162,0.9533226328779422,0.0207600962495119,7467]
["High","Q5PRF9","protein Smaug homolog 2 [OS=Homo sapiens]",30,11,26,11,694,75.4,6.83,54.45,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMD4B","ENSG00000179134","","","",642.1,668.7,677,679.6,704,697,0.9553974814957225,-0.06582702113284233,0.07278178773059116,1.1379772810938964,0.21141376436028858,0.6748667408170486,2688]
["High","Q5RI15-1","Cytochrome c oxidase protein 20 homolog [OS=Homo sapiens]",22,2,3,2,118,13.3,8.76,10.54,"cell organization and biogenesis","other membranes;mitochondrion","","COX20; FAM36A","ENSG00000203667","Mitochondrial complex IV assembly","TP53 Regulates Metabolic Genes; Respiratory electron transport; Cytoprotection by HMOX1","Thermogenesis",306.7,299.8,281.6,293,330.5,322.9,0.9383981403212174,-0.09172794059171653,0.2283814837313432,0.6413391098801359,0.42396638729774794,0.3726685735718028,4206]
["Medium","Q5SNT2-1","Transmembrane protein 201 [OS=Homo sapiens]",2,1,1,1,666,72.2,9.22,1.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TMEM201","ENSG00000188807; ENSPTRG00000049393","","","",39.9,62.9,61.1,54,45.2,43.4,1.1493688639551192,0.2008418726555707,0.42909591999947866,0.3674456148780403,0.6253043940567244,0.20390851949159494,5358]
["High","Q5SRD1","Putative mitochondrial import inner membrane translocase subunit Tim23B [OS=Homo sapiens]",14,2,8,2,257,28,9.39,24.02,"","","","","","","","",334.9,371.7,318.1,342.2,461.5,403.5,0.848823724320742,-0.23646311525866803,0.18379717944743665,0.7356611575843645,0.37294396494947646,0.4283564162915044,3848]
["High","Q5SYC1-1","Clavesin-2 [OS=Homo sapiens]",6,1,1,1,327,38,6.2,3.32,"cell organization and biogenesis","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLVS2; LOC101343624","ENSAMEG00000028872; ENSCAFG00000001006; ENSCATG00000031634; ENSCSAG00000016282; ENSDLEG00000011174; ENSECAG00000006114; ENSFCAG00000010835; ENSG00000146352; ENSGGOG00000027351; ENSLAFG00000007550; ENSMFAG00000003285; ENSMLEG00000033559; ENSMMUG00000018176; ENSMNEG00000035011; ENSNLEG00000013863; ENSOARG00000008112; ENSPANG00000003404; ENSPCOG00000011744; ENSPPAG00000036654; ENSPPYG00000016981; ENSPTRG00000018566; ENSRBIG00000041651; ENSRROG00000010239; ENSSSUG00005005271; ENSSTOG00000001439; ENSTTRG00000010743; ENSUAMG00000008720; ENSUMAG00000001385; ENSVVUG00000000265","","Lysosome Vesicle Biogenesis; Lysosome Vesicle Biogenesis","",21.9,23.3,22.8,25.6,18.6,23.6,1.0029498525073746,4.2494730013577665E-3,0.976437530114945,0.01035553649718075,0.9878238190123725,0.005320506073923201,7718]
["High","Q5T0D9","Tumor protein p63-regulated gene 1-like protein [OS=Homo sapiens]",21,2,5,2,272,30.2,7.34,18.33,"other biological processes","other membranes;ER/Golgi;other cell component","","TPRG1L","ENSG00000158109","","","",90.2,74.4,74.8,87.6,82.9,84,0.9406679764243617,-0.08824250401955533,0.40337325759205134,0.3942928975590127,0.60151611827325,0.22075273077909546,5236]
["High","Q5T160","probable arginine--tRNA ligase, mitochondrial [OS=Homo sapiens]",22,11,12,11,578,65.5,8.21,25.19,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","RARS2","ENSG00000146282","","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",460.5,528.2,442.9,425.8,484.1,475.5,1.0333477695972282,0.047325869921112734,0.6527271183011136,0.18526834366394748,0.7979479160317983,0.09802545516329707,6387]
["High","Q5T2E6-1","UPF0668 protein C10orf76 [OS=Homo sapiens]",5,3,5,3,689,78.7,6.6,10.73,"other biological processes","other membranes;cytosol;ER/Golgi","","ARMH3","ENSG00000120029; ENSNLEG00000014964; ENSPTRG00000002879","","","",153.7,148.5,143.8,159.5,165.2,152.7,0.9342270632593213,-0.09815485627410961,0.0855699083432031,1.0676789331978336,0.23263573967400064,0.6333235641094609,2872]
["Medium","Q5T4F4-1","Protrudin [OS=Homo sapiens]",4,1,1,1,411,45.8,5.15,0,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ZFYVE27","ENSG00000155256","","","Endocytosis",32,47.3,25.3,25.9,38.2,31.4,1.0952879581151833,0.13131021332383044,0.703587363059539,0.1526819693891012,0.8322390744991487,0.07975189748205098,6601]
["High","Q5T5U3-3","Isoform 3 of Rho GTPase-activating protein 21 [OS=Homo sapiens]",6,5,7,1,1164,129.2,8.44,11.46,"","","","","","","","",24.5,22.1,28.9,26.5,32.9,31,0.8351769911504424,-0.25984612820274655,0.14527258153008507,0.8378163458797689,0.32224099903037057,0.49181920469926454,3520]
["Medium","Q5T7M9-1","Protein FAM69A [OS=Homo sapiens]",3,1,1,1,428,49,7.17,0,"","other membranes;ER/Golgi","","DIPK1A","ENSG00000154511; ENSPCOG00000022059; ENSPTRG00000000964","","","",68.4,71.3,69.7,43,74.9,58.3,1.1884222474460842,0.24904751801039499,0.2975790877792023,0.5263975918802181,0.4990329719458787,0.30187075886341475,4656]
["High","Q5T8A7","Protein phosphatase 1 regulatory subunit 26 [OS=Homo sapiens]",1,1,1,1,1209,127.3,8.59,3.09,"other biological processes","nucleus","enzyme regulator activity","PPP1R26","ENSG00000196422","","","",20.2,21.5,18.8,33.8,19.1,25.4,0.7726692209450832,-0.3720771651290835,0.2423527900443945,0.615551976172664,0.4399652603270477,0.35658161406812044,4301]
["High","Q5TAX3","Terminal uridylyltransferase 4 [OS=Homo sapiens]",16,23,37,23,1644,185,7.97,69.36,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TUT4","ENSG00000134744","","Deadenylation of mRNA","",1518.8,1446.1,1540.7,1841.1,1759.3,1778.5,0.8376433843350871,-0.2555919287120353,1.5268490155863582E-3,2.8162039065844837,0.025973065607185805,1.5854767874631095,459]
["High","Q5TC63","Growth hormone-regulated TBC protein 1 [OS=Homo sapiens]",11,3,6,3,336,38.5,8.78,2.46,"transport;other biological processes","","enzyme regulator activity","GRTP1","ENSG00000139835","","","",308.2,319.6,308.5,225.8,305.6,286,1.1454612184976753,0.19592861461970748,0.17823582004693023,0.7490050113797888,0.36622770603327137,0.4362488033379636,3800]
["High","Q5TFE4","5'-nucleotidase domain-containing protein 1 [OS=Homo sapiens]",40,11,29,11,455,51.8,6.35,39.56,"other metabolic processes","","other molecular function","NT5DC1","ENSG00000178425","","","",1306,1314.2,1470.5,1319.2,1239.4,1276.4,1.0666753585397653,0.09312116033316103,0.2173942714571821,0.662751904165611,0.41199380377128103,0.38510931554011024,4120]
["High","Q5U4P2","Aspartate beta-hydroxylase domain-containing protein 1 [OS=Homo sapiens]",3,1,1,1,390,41.1,8.56,2.56,"protein metabolism;other metabolic processes","other membranes","other molecular function","ASPHD1","ENSG00000174939","16p11.2 proximal deletion syndrome","","",49.8,49.7,49.4,63.8,69.5,54.6,0.7924427887174029,-0.33562131283795554,0.04018679663619246,1.3959166108438288,0.14724472460600221,0.8319602558993954,2131]
["High","Q5VST6-1","Protein ABHD17B [OS=Homo sapiens]",6,2,5,2,288,32.2,6.29,9.62,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","Abhd17b; ABHD17B; FAM108B1; LOC111153563; LOC112838645","ENSAMEG00000007245; ENSBIXG00000020353; ENSBIXG00005014706; ENSBMUG00000011067; ENSBTAG00000006816; ENSCATG00000030905; ENSCHIG00000013948; ENSCSAG00000008296; ENSDLEG00000009276; ENSECAG00000020790; ENSG00000107362; ENSLCNG00005018778; ENSMFAG00000001017; ENSMMUG00000018880; ENSNLEG00000001017; ENSPANG00000025076; ENSPCOG00000021794; ENSPPAG00000033499; ENSPPYG00000019288; ENSRFEG00010009213; ENSRROG00000042653; ENSSBOG00000018778; ENSSSCG00070028547; ENSSSUG00005013616; ENSUAMG00000021312","","RAS processing; RAS processing","",94.6,107.4,99.9,73.3,74,81.2,1.321225382932166,0.40187659156819283,0.005510641301011013,2.258797857176584,0.046067545265839394,1.336604928748042,934]
["High","Q5VT66-1","Mitochondrial amidoxime-reducing component 1 [OS=Homo sapiens]",31,8,27,7,337,37.5,8.88,56.93,"other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;other cell component","other molecular function","MTARC1","ENSG00000186205","","Phase I - Functionalization of compounds","",604.4,623.5,600.5,657.9,606.4,648.5,0.9558762024257633,-0.06510431110759302,0.18034006302913877,0.7439077828743482,0.36870783245130023,0.4333176365890306,3819]
["High","Q5VTR2","E3 ubiquitin-protein ligase BRE1A [OS=Homo sapiens]",51,45,129,43,975,113.6,5.94,291.67,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNF20","ENSG00000155827","ATM signaling in development and disease","E3 ubiquitin ligases ubiquitinate target proteins; RHOBTB1 GTPase cycle","",5295.3,4937.5,5290,4686.5,4731.9,4688.4,1.1003771230895738,0.13799805135681734,0.016736214995692066,1.7763427537710557,0.0864833664370375,1.0630674134514457,1511]
["High","Q5VV42","threonylcarbamoyladenosine tRNA methylthiotransferase [OS=Homo sapiens]",23,8,16,8,579,65.1,7.46,36.1,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;ER/Golgi","other molecular function","CDKAL1","ENSG00000145996","Vitamin D receptor pathway","tRNA modification in the nucleus and cytosol","",234.7,210.9,235.1,231.5,229,241,0.9703492516037063,-0.04342399411376794,0.4746582466306566,0.32361896936744244,0.6643003387152118,0.1776355261191762,5579]
["High","Q5VWN6-1","Protein FAM208B [OS=Homo sapiens]",7,12,15,12,2430,268.7,5.9,32.35,"","cytosol;nucleus","","TASOR2","ENSG00000108021","","","",508.2,516.9,495.3,586.1,565.5,566.6,0.8848795250843907,-0.1764470469173108,1.9845200111438333E-3,2.7023445174746175,0.028962864013104765,1.5381584948372107,535]
["Low","Q5VYS4-1","Mesenteric estrogen-dependent adipogenesis protein [OS=Homo sapiens]",3,1,1,1,303,34.2,6.3,0,"other biological processes","other cell component","","MEDAG","ENSG00000102802","","","",81.8,87.5,104.2,96,88.3,75,1.0547628229849595,0.07691862682662426,0.6303937002087427,0.20038813558552354,0.7844006392398188,0.1054620610799639,6275]
["High","Q5VZL5","Zinc finger MYM-type protein 4 [OS=Homo sapiens]",17,22,51,21,1548,172.7,6.84,94.29,"cell organization and biogenesis;developmental processes;other biological processes","","nucleic acid binding activity;other molecular function","ZMYM4","ENSG00000146463","","","",2018.2,1982.2,1987.6,2135,2278,2168.1,0.9098782878242238,-0.13625452242904262,0.011441162351921793,1.941529851645936,0.07061865268285009,1.1510805724991373,1265]
["High","Q5XUX0-1","F-box only protein 31 [OS=Homo sapiens]",3,1,1,1,539,60.6,7.02,3.8,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","FBXO31","ENSG00000103264","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",19.8,29,17,15.5,18.6,14.6,1.351129363449692,0.43416581165289925,0.210105990296417,0.6775615653208809,0.40356889845865285,0.39408231059233245,4065]
["High","Q63HQ0","AP-1 complex-associated regulatory protein [OS=Homo sapiens]",7,3,5,3,302,34.3,4.87,9.71,"transport;other biological processes","cytosol;ER/Golgi;other cytoplasmic organelle","cytoskeletal activity;other molecular function","AP1AR","ENSG00000138660","","","",255.8,237.3,242.6,214.3,203.2,210.9,1.1707511139401656,0.22743441072558637,0.005046099854071797,2.297044159755166,0.04417034491097824,1.3548692094726535,892]
["High","Q66K64","DDB1- and CUL4-associated factor 15 [OS=Homo sapiens]",12,5,8,5,600,66.4,6.58,21.51,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","DCAF15","ENSG00000132017; ENSG00000288453","","","",289.9,321.6,297.8,352.8,360.3,356.6,0.8500514162849396,-0.23437798801832999,0.005425028194663008,2.265598000381784,0.045595931263647756,1.3410739097167905,929]
["High","Q676U5","Autophagy-related protein 16-1 [OS=Homo sapiens]",21,11,18,11,607,68.2,6.64,40.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","ATG16L1","ENSG00000085978; ENSG00000281089","Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy","Macroautophagy","Autophagy; Autophagy; NOD-like receptor signaling pathway; Shigellosis",687.5,634.8,698.8,732.3,638.1,672.9,0.9891352224342973,-0.01576033285143533,0.837611955799388,0.07695713230743292,0.913418177497433,0.03933034995665313,7160]
["High","Q68CP9-1","AT-rich interactive domain-containing protein 2 [OS=Homo sapiens]",10,15,23,15,1835,197.3,7.42,48.14,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;nucleus","nucleic acid binding activity;other molecular function","ARID2","ENSG00000189079","","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Hepatocellular carcinoma",761.6,822.3,799,982,1070.8,1038.3,0.7708906214616156,-0.37540191836465203,1.6738452065202243E-3,2.776284707073021,0.026836516165318094,1.5712738636290198,487]
["High","Q68D06","Schlafen family member 13 [OS=Homo sapiens]",3,2,2,2,897,102,6.96,6.51,"RNA metabolism OR transcription;other metabolic processes;stress response","other cell component","nucleic acid binding activity;other molecular function","SLFN13","ENSG00000154760","","","",57.6,57.8,48.8,57.1,69.3,71.1,0.8313924050632912,-0.2663985261740228,0.10454731877522262,0.9806871006373862,0.26214048330023704,0.5814659042108523,3114]
["High","Q68E01-2","Isoform 2 of Integrator complex subunit 3 [OS=Homo sapiens]",12,10,34,10,1042,117.9,5.8,83.06,"","","","INTS3","","","","",871.2,909.2,991.2,1028.4,1036.5,1046.6,0.8907600835609835,-0.16689118487446838,0.03402089507083835,1.46825426452673,0.132420313416304,0.878045388552494,2006]
["High","Q69YN2-1","CWF19-like protein 1 [OS=Homo sapiens]",18,6,14,6,538,60.6,7.24,36.93,"RNA metabolism OR transcription;other metabolic processes","nucleus","enzyme regulator activity","CWF19L1","ENSG00000095485","","","",281.8,259.5,289.9,340,320.1,336.9,0.8337011033099299,-0.2623978503813464,0.007344869835506507,2.1340158962960754,0.05466991770794548,1.262251579830998,1049]
["High","Q6AI39","BRD4-interacting chromatin-remodeling complex-associated protein-like [OS=Homo sapiens]",2,2,2,2,1079,115,6.87,2.43,"other biological processes","nucleus","","BICRAL","ENSG00000112624","","","",68.5,56.6,93,86.5,76.6,92.2,0.8542890716803759,-0.22720376776636847,0.346939814070704,0.459745858592561,0.5485836509242724,0.26075713952983903,4938]
["High","Q6DD88","Atlastin-3 [OS=Homo sapiens]",24,9,18,9,541,60.5,5.66,40.43,"cell organization and biogenesis;other biological processes","other membranes;ER/Golgi","other molecular function","ATL3","ENSG00000184743","","","",828.7,894.2,838.3,844.8,854.4,883,0.9918673998915654,-0.01178083143810017,0.7799483035497221,0.10793418221610503,0.8786374771484966,0.05619027640456342,6931]
["High","Q6F5E8","capping protein, Arp2/3 and myosin-I linker protein 2 [OS=Homo sapiens]",9,9,10,9,1435,154.6,6.76,20.36,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","CARMIL2","ENSG00000159753","","","",243.2,235.3,249.6,312.6,247.3,256.1,0.8922794117647057,-0.1644325429865683,0.23305559070121465,0.6325404744453418,0.4287695693202366,0.3677760450160094,4244]
["High","Q6I9Y2","THO complex subunit 7 homolog [OS=Homo sapiens]",19,3,3,3,204,23.7,5.67,5.61,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","THOC7","ENSG00000163634","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Nucleocytoplasmic transport",201.5,184.3,155.8,190.5,182.9,168.2,1.0000000000000002,3.2034265038149176E-16,1,0,1.0005125576627372,-2.2254393615498815E-4,7804]
["High","Q6IBS0","Twinfilin-2 [OS=Homo sapiens]",44,13,48,10,349,39.5,6.84,110.24,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","TWF2","ENSG00000247596","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",1958.2,2032.6,1932.2,1661.8,1841.9,1711.5,{"$f":"AVERAGE(T3906:V3906)/AVERAGE(W3906:Y3906)","v":1.1357186685074399},{"$f":"LOG(Z3906,2)","v":0.18360550577992196},{"$f":"TTEST(T3906:V3906,W3906:Y3906,2,2)","v":0.018571920571495357},{"$f":"-LOG10(AB3906)","v":1.731143182395215},{"$f":"AB3906*7808/AF3906","v":0.0917201491601744},{"$f":"-LOG10(AD3906)","v":1.037535247668789},1581]
["Medium","Q6IQ26","DENN domain-containing protein 5A [OS=Homo sapiens]",2,1,1,1,1287,147,6.65,0,"transport;other biological processes","other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","DENND5A","ENSG00000184014","","RAB GEFs exchange GTP for GDP on RABs","",20.4,8.4,17,10.1,13.1,16.5,1.1536523929471032,0.20620859095398605,0.6396806467879746,0.19403678844193842,0.7901639756558307,0.10228277411106562,6321]
["Medium","Q6IQ55","tau-tubulin kinase 2 [OS=Homo sapiens]",1,1,1,1,1244,137.3,7.01,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","TTBK2","ENSG00000128881","Genes related to primary cilium development (based on CRISPR); Ciliopathies","Anchoring of the basal body to the plasma membrane","",70.7,84.7,70.3,75.8,74,76.2,0.9986725663716814,-1.9163541107139526E-3,0.9843203671629241,0.006863528553786809,0.9923271048170577,3.3451459903762254E-3,7745]
["High","Q6N075","Molybdate-anion transporter [OS=Homo sapiens]",3,1,4,1,450,49.7,7.8,0,"transport","plasma membrane;other membranes","transporter activity","MFSD5","ENSG00000182544","","","",96.8,90.9,104.3,89.5,104.6,101,0.9894950864113858,-0.01523555166462776,0.8712163558955337,0.05987397989082678,0.9310781969384515,0.031013843108089263,7306]
["Medium","Q6NT16","MFS-type transporter SLC18B1 [OS=Homo sapiens]",2,1,1,1,456,48.8,5.22,0,"transport","other membranes","transporter activity","SLC18B1","ENSG00000146409","","","",14.5,13.4,14.2,15.7,16.9,11.6,0.9524886877828054,-0.07022613632503558,0.691080658691243,0.16047126148220753,0.8241878391723271,0.08397379774556875,6547]
["High","Q6NUQ4","Transmembrane protein 214 [OS=Homo sapiens]",15,8,20,8,689,77.1,9.14,37.79,"other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi","","TMEM214","ENSG00000119777","","","",858.6,880.4,890.1,829.5,840.5,895.7,1.0247106052929027,0.035216527039247845,0.40076612736356043,0.3971089920328958,0.5994601384012797,0.22223969037652255,5220]
["High","Q6NW29","RWD domain-containing protein 4 [OS=Homo sapiens]",11,2,5,2,188,21.2,5.31,10.8,"","","","RWDD4","ENSG00000182552","","","",202.4,192.6,189,199.4,176.3,182,1.0471579702348932,0.06647909812674167,0.33570200468332884,0.4740460653045399,0.5370131638122171,0.2700150683024257,4881]
["High","Q6NYC1","Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 [OS=Homo sapiens]",15,5,11,5,403,46.4,8.69,32.12,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","JMJD6","ENSG00000070495","","HDMs demethylate histones","",331.6,343.6,328.6,348.1,391.9,359,0.9133757961783441,-0.13071953507708442,0.08511683431813981,1.0699845371135202,0.23205036395112977,0.6344177460907027,2864]
["High","Q6P1A2","Lysophospholipid acyltransferase 5 [OS=Homo sapiens]",10,4,10,4,487,56,8.69,17.01,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","LPCAT3","ENSG00000111684","Ferroptosis","Acyl chain remodelling of PC; Acyl chain remodelling of PS; Acyl chain remodelling of PE","Glycerophospholipid metabolism; Ferroptosis",375.6,349,331.7,275.9,366.4,339.2,1.0762098828323992,0.10595946023075366,0.4483436580698866,0.3483889690626887,0.6416179036308054,0.1927235260524758,5456]
["High","Q6P1M0","Long-chain fatty acid transport protein 4 [OS=Homo sapiens]",16,7,9,7,643,72,8.47,24.82,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","SLC27A4","ENSG00000167114","PPAR signaling pathway; Fatty acid transporters","Transport of fatty acids; Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)","PPAR signaling pathway; Insulin resistance; Fat digestion and absorption",218.8,206.9,247.2,206,227.2,233.2,1.0097539015606245,0.014003720441881218,0.8886392226905373,0.05127452181523213,0.9413234365442565,0.02626112835634009,7371]
["High","Q6P1R4","tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like [OS=Homo sapiens]",16,5,5,5,473,53.2,8.29,5.5,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","DUS1L","ENSG00000169718","","","",116,105.8,120.4,125.4,131.7,127.4,0.8899869960988298,-0.16814383835977523,0.04010843755903711,1.3967642558120479,0.14709566954483877,0.8324001125917351,2129]
["High","Q6P4A8","Phospholipase B-like 1 [OS=Homo sapiens]",10,4,14,4,553,63.2,9.06,29.02,"other metabolic processes","non-structural extracellular;cytosol;other cytoplasmic organelle","other molecular function","PLBD1","ENSG00000121316","","Acyl chain remodelling of PC; Acyl chain remodelling of PE; Acyl chain remodelling of PI; Hydrolysis of LPC","",546.8,528.5,515.4,519.8,510.4,542.8,1.0112523839796566,0.016143103744572066,0.6791256331430072,0.16804987706901073,0.8164146179492842,0.08808922781942198,6495]
["High","Q6P4E1","Protein CASC4 [OS=Homo sapiens]",15,6,10,6,433,48.8,5.82,17.92,"","","","","","","","",275.5,294,316.6,258.9,269,275.2,1.1033495206076454,0.14188988228934238,0.09670072369914241,1.014570275685685,0.2511773954234544,0.6000194472779388,3006]
["High","Q6P9B6","TLD domain-containing protein 1 [OS=Homo sapiens]",12,4,7,4,456,51,6.24,17.31,"signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","","MEAK7","ENSG00000140950","","","",333.7,382.4,353.8,376.7,339.3,361.9,0.9925781612394469,-0.010747382160602798,0.8883478184351401,0.0514169598390642,0.9412701542056688,0.026285711703220072,7369]
["High","Q6PCT2-1","F-box/LRR-repeat protein 19 [OS=Homo sapiens]",2,2,3,2,694,75.7,9.17,1.75,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","FBXL19","ENSG00000099364; ENSGGOG00000003625; ENSPTRG00000008021","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",171.4,175.6,197.2,226.8,197.7,210.3,0.8572778827977316,-0.22216517158550317,0.06001941594375375,1.2217082350630992,0.18858414474399568,0.7244948234738148,2485]
["High","Q6PD74","Alpha- and gamma-adaptin-binding protein p34 [OS=Homo sapiens]",18,4,21,4,315,34.6,4.64,69.18,"transport","cytosol;nucleus;other cell component","","AAGAB","ENSG00000103591","","","",831.1,811.3,877,748.7,774.5,705.7,1.1303333482883935,0.1767483027300004,0.025716740341223177,1.5897840801309613,0.11261711081563126,0.9483956186476806,1783]
["High","Q6PIW4","Fidgetin-like protein 1 [OS=Homo sapiens]",16,7,9,6,674,74,7.85,16.75,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","FIGNL1","ENSG00000132436","","","",138,163.1,137.2,155.2,195.5,167.6,0.8456492378931122,-0.2418687148600446,0.14262108888526193,0.8458162521186106,0.318987528506481,0.496226296274154,3491]
["High","Q6PJW8","Consortin [OS=Homo sapiens]",8,4,6,4,725,79.5,4.53,11.79,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","CNST","ENSG00000162852","","","",302.6,276.1,311.3,288.7,252.8,273.5,1.0920245398773005,0.12700527673532008,0.1673947950136498,0.7762580501181109,0.35229610767293196,0.4530921550745214,3710]
["High","Q6PL24","Protein TMED8 [OS=Homo sapiens]",13,3,5,3,325,35.7,4.74,10.14,"","","","TMED8","ENSG00000100580","","","",79.7,74.7,88.5,80.1,76.8,73.4,1.0547112462006079,0.07684807884301936,0.4009576507435223,0.3969014952592525,0.5995169163166262,0.22219855808754277,5222]
["High","Q6RFH5-1","WD repeat-containing protein 74 [OS=Homo sapiens]",48,12,22,12,385,42.4,8.32,50.14,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","","WDR74","ENSG00000133316","","","",666.2,663,701.7,802.2,763.2,791.4,{"$f":"AVERAGE(T4034:V4034)/AVERAGE(W4034:Y4034)","v":0.8617192803801765},{"$f":"LOG(Z4034,2)","v":-0.21471013133037037},{"$f":"TTEST(T4034:V4034,W4034:Y4034,2,2)","v":3.0773393552773923E-3},{"$f":"-LOG10(AB4034)","v":2.5118246090506027},{"$f":"AB4034*7808/AF4034","v":0.033652472949588064},{"$f":"-LOG10(AD4034)","v":1.4729830161681419},714]
["High","Q6UB35-1","Monofunctional C1-tetrahydrofolate synthase, mitochondrial [OS=Homo sapiens]",22,20,54,19,978,105.7,8.06,110.51,"other metabolic processes;developmental processes","cytosol;mitochondrion","other molecular function","MTHFD1L","ENSG00000120254","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism","Metabolism of folate and pterines","One carbon pool by folate; Metabolic pathways; Biosynthesis of cofactors",1902.1,1965.9,1969.4,2031.4,2071.1,2039.1,0.9504689331770222,-0.07328862286248389,0.015448245883926775,1.8111208266715186,0.08278648171702145,1.0820405737828733,1457]
["High","Q6ULP2","Aftiphilin [OS=Homo sapiens]",9,6,9,6,937,102.1,4.54,14.03,"","","","","","","","",238.1,240.6,266.9,237.4,221,212.9,1.110680768657828,0.15144421757854512,0.10161737023242268,0.9930320484369963,0.2584457416204418,0.5876306192555473,3070]
["High","Q6UW68","Transmembrane protein 205 [OS=Homo sapiens]",9,1,5,1,189,21.2,8.62,8.89,"","other membranes","","TMEM205","ENSG00000105518","","","",63.6,85.9,78.3,72,72.3,61.3,1.107976653696498,0.14792748251423354,0.37843472814155155,0.4220090161703795,0.5798309178432564,0.23669863083903817,5096]
["High","Q6UWZ7","BRCA1-A complex subunit Abraxas 1 [OS=Homo sapiens]",9,4,5,4,409,46.6,7.05,6.94,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","cytoskeletal activity;other molecular function","ABRAXAS1","ENSG00000163322","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Homologous recombination",331.9,290.7,334,396.3,349.7,374.8,0.8534975017844396,-0.22854116444451275,0.04843285053864957,1.3148599695911958,0.16513698559204185,0.7821556472724482,2290]
["Medium","Q6UX68","XK-related protein 5 [OS=Homo sapiens]",1,1,1,1,686,74.9,6.68,0,"","","","","","","","",23.6,16.5,14.3,16.8,22.1,20,0.9235993208828523,-0.11466098258012121,0.6637875368490718,0.1779709060830169,0.8060424708736473,0.0936420743486036,6430]
["High","Q6V1X1","Dipeptidyl peptidase 8 [OS=Homo sapiens]",6,5,5,4,898,103.3,5.8,13.75,"protein metabolism;other biological processes","cytosol;other cell component","other molecular function","DPP8","ENSG00000074603","","","",265.1,244.5,257.8,264.1,260.7,255.7,0.9832158872517618,-0.024419867262477878,0.5388137769062391,0.268561308350195,0.7151211915831914,0.14562035207900603,5883]
["High","Q6VEQ5","WAS protein family homolog 2 [OS=Homo sapiens]",11,4,8,4,465,50.3,5.71,11.75,"cell organization and biogenesis;transport","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity","WASH2P","","","","",263.4,265,271.2,332.4,297.9,287.6,0.8711188582634274,-0.19905851667367155,0.04560646847416523,1.3409735559450495,0.15925550350907072,0.7979055505007999,2236]
["High","Q6XZF7","Dynamin-binding protein [OS=Homo sapiens]",5,5,5,5,1577,177.2,5.39,9.6,"signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity","DNMBP","ENSG00000107554","","CDC42 GTPase cycle","",72.7,78.6,80,58.5,57.1,62.4,1.299438202247191,0.3778880247824305,2.923580693665035E-3,2.534084914712003,0.03313108571282525,1.4797643319609932,689]
["High","Q6Y7W6-1","GRB10-interacting GYF protein 2 [OS=Homo sapiens]",34,41,102,40,1299,150,5.54,190.35,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GIGYF2","ENSG00000204120","VEGFA-VEGFR2 signaling pathway","","",4064.5,3533.8,3960.7,4138.3,3581,3682.8,1.0137606230431235,0.019717032303297768,0.8355162362670058,0.07804510621026184,0.9125347283218326,0.039750598617744985,7149]
["High","Q6ZN17-1","Protein lin-28 homolog B [OS=Homo sapiens]",44,9,24,7,250,27.1,8.91,34.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","LIN28B","ENSG00000187772","Cardiac progenitor differentiation; Hippo-Merlin signaling dysregulation; Malignant pleural mesothelioma; CCL18 signaling pathway","","",537.3,497.5,542.7,650.3,559.4,555.2,0.8938183466485354,-0.16194643687718746,0.14128040511990766,0.8499180684303788,0.3167147295940968,0.49933173822997956,3483]
["High","Q6ZPD9-1","probable C-mannosyltransferase DPY19L3 [OS=Homo sapiens]",7,3,4,3,716,83.1,8.72,8.3,"protein metabolism;other metabolic processes","other membranes;nucleus","other molecular function","DPY19L3","ENSG00000178904; ENSPPAG00000028384","","","",19.6,25.3,27.4,23.2,21.1,17.7,1.1661290322580646,0.2217274316768804,0.2915088724315178,0.5353482224164269,0.4925559999881608,0.30754438627649644,4621]
["High","Q6ZRS2","Helicase SRCAP [OS=Homo sapiens]",5,14,28,13,3230,343.3,5.96,54.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","SRCAP","ENSG00000080603","Pathways affected in adenoid cystic carcinoma","","",671,616.5,681.8,768.7,716.3,751.4,0.8805669826506884,-0.18349534425227326,0.02482945084104587,1.6050328857350407,0.10953014246716732,0.9604663474382119,1770]
["High","Q6ZTU2","EP400 N-terminal-like protein [OS=Homo sapiens]",5,1,1,1,488,51.7,7.27,0,"","","","EP400P1","","","","",10.3,15.2,18.7,19.4,15,14.8,0.8983739837398373,-0.1546119459478084,0.5915105374806959,0.22803751421617555,0.7537970094090539,0.12274558988949412,6127]
["High","Q6ZV29-1","Patatin-like phospholipase domain-containing protein 7 [OS=Homo sapiens]",1,2,4,1,1317,145.6,7.74,0,"","","","","","","","",28.3,19.3,26.1,24.9,30,22.4,0.9534282018111255,-0.06880379482977764,0.749829437254167,0.12503751378630826,0.8619947358775818,0.06449538636356912,6792]
["High","Q6ZW49","PAX-interacting protein 1 [OS=Homo sapiens]",4,4,7,4,1069,121.3,6.7,24.58,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","","PAXIP1","ENSG00000157212","16p11.2 proximal deletion syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nonhomologous End-Joining (NHEJ)","",102,105.2,103.7,114,113.2,113.7,0.9119976532707539,-0.13289798279888218,4.6698788327236446E-4,3.330694387734142,0.01599228680960799,1.7960894300759602,228]
["Medium","Q70CQ4-1","Ubiquitin carboxyl-terminal hydrolase 31 [OS=Homo sapiens]",1,2,2,2,1352,146.6,9.22,2.03,"protein metabolism;other metabolic processes","nucleus","other molecular function","USP31","ENSG00000103404","","","",52.3,59.3,73.4,52.4,57.8,54.6,1.1225728155339807,0.16680902822045623,0.3521125273336572,0.4533185234810849,0.5541815386859898,0.2563479458586351,4961]
["High","Q70UQ0","Inhibitor of nuclear factor kappa-B kinase-interacting protein [OS=Homo sapiens]",20,8,17,5,350,39.3,9.17,28.46,"other biological processes","other membranes;ER/Golgi","","IKBIP","ENSG00000166130","","","",718.8,751.3,761.2,754.5,775.8,817.2,0.9505005324813632,-0.07324065979890383,0.1591800421582001,0.7981113846128484,0.3427682761089979,0.4649993797137028,3626]
["High","Q712K3","Ubiquitin-conjugating enzyme E2 R2 [OS=Homo sapiens]",8,3,8,3,238,27.1,4.42,16.66,"protein metabolism;other metabolic processes","cytosol","other molecular function","UBE2R2","ENSG00000107341","","Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes","Ubiquitin mediated proteolysis",442.6,471.5,410.8,560,518.8,506.6,0.835688154408982,-0.2589634085851328,0.021914340186201465,1.6592716008852504,0.1013067899193967,0.9943614457976236,1689]
["High","Q71UM5","40S ribosomal protein S27-like [OS=Homo sapiens]",39,3,17,1,84,9.5,9.45,25.77,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;translational apparatus;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPS27L","ENSG00000185088","","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",184,159.4,211,213.7,186.1,213.2,0.9044045676998368,-0.14495981644093026,0.32611798694343486,0.4866252471466588,0.5271903192659088,0.27803257323953556,4830]
["High","Q76NI1-1","Protein very KIND [OS=Homo sapiens]",3,4,4,4,1749,191.3,6.16,8.25,"developmental processes;signal transduction;other biological processes","other cell component","enzyme regulator activity","KNDC1","ENSG00000171798","","","",158.7,185,152.3,203.9,192.9,184.7,0.8529664660361135,-0.22943907108634323,0.06751161137485846,1.1706215260971278,0.20150254648887417,0.695719461090722,2616]
["High","Q7KZF4","staphylococcal nuclease domain-containing protein 1 [OS=Homo sapiens]",55,49,244,49,910,101.9,7.17,624.26,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SND1","ENSG00000197157","VEGFA-VEGFR2 signaling pathway","Signaling by BRAF and RAF1 fusions","Viral carcinogenesis",9429.6,9567,9431.7,8292.7,8623.4,8547.3,1.1164377105963856,0.15890276112854074,8.4466542756501711E-4,3.073315281270192,0.019454712856718744,1.710975174814639,339]
["High","Q7L190","Developmental pluripotency-associated protein 4 [OS=Homo sapiens]",54,15,66,15,304,33.5,9.52,153.1,"developmental processes","nucleus","other molecular function","DPPA4","ENSG00000121570","","POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","",3308.7,3310.9,3284.7,4729.3,4706.9,4642.2,0.7035103420843276,-0.5073564626635063,9.0375700314684462E-7,6.043948324368232,2.3521782268568544E-3,2.6285297744292597,3]
["Low","Q7L211","Protein Abhd13 [OS=Homo sapiens]",2,1,1,1,337,38.5,8.57,1.73,"protein metabolism;other metabolic processes","other membranes;other cell component","other molecular function","ABHD13","ENSG00000139826","","","",47.5,51.7,49.6,49.1,46.5,37.5,1.1179564237415478,0.16086395519613975,0.2319820640145839,0.6345455918358823,0.42749963555012305,0.36906425117823655,4237]
["High","Q7L3B6","Hsp90 co-chaperone Cdc37-like 1 [OS=Homo sapiens]",15,5,10,5,337,38.8,5.34,21.18,"other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","CDC37L1","ENSG00000106993","","Platelet degranulation","",600.4,627.6,571.9,481.2,445.6,451.5,1.3058840600740043,0.38502681619428414,1.9620544257075525E-3,2.707288949832406,0.028688616022330655,1.5422904022023274,534]
["High","Q7L5N7","Lysophosphatidylcholine acyltransferase 2 [OS=Homo sapiens]",6,3,4,3,544,60.2,6.55,8.36,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","LPCAT2","ENSG00000087253","","Acyl chain remodelling of PC","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways",144.1,116.6,129.5,107.3,120,121.2,1.1196556671449067,0.1630551218532409,0.2015023355668429,0.6957199156870724,0.3931359910309619,0.4054571953286295,4002]
["High","Q7L7L0","Histone H2A type 3 [OS=Homo sapiens]",35,6,156,1,130,14.1,11.05,351.11,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","H2AW","ENSG00000181218; ENSG00000284841","","HATs acetylate histones; HCMV Early Events; HCMV Late Events; Ub-specific processing proteases; UCH proteinases; RMTs methylate histone arginines; HDACs deacetylate histones; Metalloprotease DUBs","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus",9.5,11.6,20.7,31.1,21.5,32,0.49408983451536637,-1.0171547210390672,0.041222911019146144,1.3848613431023487,0.14984566538058336,0.8243558154712314,2148]
["High","Q7LGA3-1","Heparan sulfate 2-O-sulfotransferase 1 [OS=Homo sapiens]",18,5,8,5,356,41.9,8.69,17.7,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","HS2ST1","ENSG00000153936; ENSGGOG00000040966; ENSPPAG00000039539; ENSPTRG00000000927","Metapathway biotransformation Phase I and II","HS-GAG biosynthesis","Glycosaminoglycan biosynthesis",393.6,405.6,411.7,410.1,395.9,382,1.0192760942760943,0.027544891436053726,0.47528164555585306,0.32304895698175345,0.6648153150304731,0.17729898447573028,5582]
["High","Q7RTS7","Keratin, type II cytoskeletal 74 [OS=Homo sapiens]",5,3,14,1,529,57.8,7.71,19.02,"cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","KRT74","ENSG00000170484","","Formation of the cornified envelope","",149.9,153.6,101.3,136.9,105,139.4,1.061631261473905,0.08628275896819491,0.7174437405380685,0.1442121491331049,0.8430098910641443,0.07416732975322031,6645]
["High","Q7Z2W9","39S ribosomal protein L21, mitochondrial [OS=Homo sapiens]",42,6,14,6,205,22.8,9.89,31.77,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL21","ENSG00000197345","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",416.8,380.5,392.7,361.5,394.8,381.2,1.0461538461538462,0.06509502822188498,0.2909056235899077,0.536247883185877,0.49228242500866914,0.3077856687123163,4614]
["Low","Q7Z3D4","LysM and putative peptidoglycan-binding domain-containing protein 3 [OS=Homo sapiens]",4,1,1,1,306,34.5,5.97,0,"cell organization and biogenesis","plasma membrane;other membranes;ER/Golgi","","LYSMD3","ENSG00000176018","","","",31.1,27.9,35.2,31.8,29.4,37.3,0.9563451776649746,-0.06439666473095543,0.6728233278018897,0.17209895930288696,0.8122146789544148,0.09032916587861507,6468]
["High","Q7Z3E2","Coiled-coil domain-containing protein 186 [OS=Homo sapiens]",7,5,7,5,898,103.6,6.27,13.45,"cell-cell signaling;transport;other biological processes","ER/Golgi","other molecular function","CCDC186","ENSG00000165813","","","",234.6,206.4,208.3,234.4,210.7,221.2,0.974485967282005,-0.0372866842409602,0.6450404200499137,0.19041307039631933,0.7928960327061911,0.10078375515672378,6352]
["High","Q7Z408","CUB and sushi domain-containing protein 2 [OS=Homo sapiens]",0,1,1,1,3487,379.8,6.09,2.32,"","plasma membrane;other membranes","","CSMD2","ENSG00000121904","","","",32.1,24,27.2,34.9,34.1,31,0.833,-0.2636115992965395,0.10252481658432223,0.9891709989874468,0.25923373312512565,0.5863084859925098,3088]
["High","Q7Z4H8","KDEL motif-containing protein 2 [OS=Homo sapiens]",19,9,16,9,507,58.5,8.24,29.07,"protein metabolism;other metabolic processes","ER/Golgi;other cell component","other molecular function","POGLUT3","ENSG00000178202","","","",857.8,823,847.3,960.6,989.2,964.4,0.8675108091414452,-0.20504636117616784,7.0767192177681416E-4,3.1501680355086354,0.01841834121744455,1.7347494855696626,300]
["High","Q7Z4L5","Tetratricopeptide repeat protein 21B [OS=Homo sapiens]",7,7,7,7,1316,150.8,6.96,16,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","TTC21B","ENSG00000123607","Nephrotic syndrome; Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",218.8,228.7,229.3,201.8,243.8,232.9,0.9974944731024319,-0.003619247186266666,0.9674095713269142,0.014389620116986584,0.9837892593019727,0.007097923239737294,7678]
["High","Q7Z4W1","L-xylulose reductase [OS=Homo sapiens]",58,10,24,10,244,25.9,8.1,64.3,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","DCXR","ENSG00000169738","","Formation of xylulose-5-phosphate; Essential pentosuria","Pentose and glucuronate interconversions; Metabolic pathways",760.5,865,763.1,408.9,468.6,442.5,1.8095454545454543,0.8556273476793274,0.00075904344037625,3.119733368536885,0.0187550986786638,1.7268806464966533,316]
["High","Q7Z624","Calmodulin-lysine N-methyltransferase [OS=Homo sapiens]",7,2,4,2,323,36.1,6.83,7.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","CAMKMT","ENSG00000143919","","Inactivation, recovery and regulation of the phototransduction cascade; Protein methylation","Lysine degradation; Metabolic pathways",160,176,146.7,158.1,195.6,156.2,0.9466562070994313,-0.07908751118395677,0.5870293793248234,0.23134016287612863,0.750045065254168,0.12491264193731977,6111]
["High","Q7Z628","Neuroepithelial cell-transforming gene 1 protein [OS=Homo sapiens]",10,4,5,4,596,67.7,9.23,11.26,"stress response;signal transduction;other biological processes","cytosol;nucleus","enzyme regulator activity","NET1","ENSG00000173848","Apoptosis-related network due to altered Notch3 in ovarian cancer","RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events","",190.3,184.1,173.8,154.6,186.4,149.8,1.116951915240424,0.1595670791628703,0.19918720309504476,0.7007385665334557,0.3903749201220154,0.4085180916264814,3984]
["High","Q7Z6M1-1","Rab9 effector protein with Kelch motifs [OS=Homo sapiens]",20,6,9,6,372,40.5,6.25,17.75,"transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","RABEPK","ENSG00000136933","","Retrograde transport at the Trans-Golgi-Network","",514.7,535.6,517.3,502.2,527.2,513,1.016338174273859,0.023380521372248206,0.4388304366148827,0.35770325804474035,0.6343988241231261,0.19763763066729848,5401]
["High","Q7Z739","YTH domain-containing family protein 3 [OS=Homo sapiens]",19,10,30,6,585,63.8,9.04,50.5,"cell organization and biogenesis;other biological processes","cytosol;other cell component","translation activity;nucleic acid binding activity","YTHDF3","ENSG00000185728","","","",772.3,777.6,806,777.5,728.7,763.9,1.0377956918197437,0.05352245197099917,0.18559034609467365,0.7314446183480564,0.37512022322216204,0.4258295218342413,3863]
["High","Q7Z7H5","Transmembrane emp24 domain-containing protein 4 [OS=Homo sapiens]",34,7,49,5,227,25.9,8.28,112.09,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED4","ENSG00000158604","","","",752.3,777.1,777.8,756.4,803,753.8,0.9974061905585336,-3.7469375426661513E-3,0.9171114567220546,0.03757788123520947,0.956304254017869,0.019403912306622854,7488]
["High","Q86SQ9","Dehydrodolichyl diphosphate synthase complex subunit DHDDS [OS=Homo sapiens]",17,4,7,4,333,38.6,8.28,10.61,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DHDDS","ENSG00000117682","","Synthesis of Dolichyl-phosphate; Defective DHDDS causes retinitis pigmentosa 59","Terpenoid backbone biosynthesis",103,93.4,91.9,95.7,85.9,95.8,1.0392934390771449,0.05560304917130384,0.4897263529777027,0.31004652525509896,0.6776153400761833,0.1690167708665049,5643]
["High","Q86TB9","Protein PAT1 homolog 1 [OS=Homo sapiens]",18,8,9,8,770,86.8,6.67,25.84,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","PATL1","ENSG00000166889","","mRNA decay by 5' to 3' exoribonuclease","RNA degradation",289,293.6,295,320.7,284.6,300.5,0.9688672996246412,-0.045629013646918695,0.4253646058108347,0.3712386501656647,0.6221893672107526,0.20607741495851817,5338]
["High","Q86TM6","E3 ubiquitin-protein ligase synoviolin [OS=Homo sapiens]",8,4,9,4,617,67.6,6.95,9.07,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","SYVN1","ENSG00000162298","","Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; XBP1(S) activates chaperone genes; ER Quality Control Compartment (ERQC)","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",235.8,303.9,271.1,265.5,247.9,268.9,1.0364310366866933,0.051624123837456265,0.6702875070237662,0.1737388750135581,0.8102809807774526,0.09136435489807232,6459]
["High","Q86U42-1","polyadenylate-binding protein 2 [OS=Homo sapiens]",69,14,44,14,306,32.7,5.06,93.31,"RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BCL2L2; BCL2L2-PABPN1; LOC101332651; LOC102975296; LOC106988220; LOC109255027; LOC110585402; LOC111164107; LOC112822568; LOC116541350; PABPN1","ENSCATG00000038536; ENSCCAG00000033954; ENSCJAG00000007960; ENSDLEG00000019901; ENSFCAG00000031922; ENSG00000100836; ENSGGOG00000022683; ENSMMUG00000014747; ENSMNEG00000045065; ENSOGAG00000008710; ENSPANG00000021100; ENSPTRG00000006167; ENSSSCG00000002023","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA surveillance pathway; Influenza A",1894.4,1948.9,1883.2,2419.8,2286.8,2371.9,0.8089990817263544,-0.3057900297964934,5.0621408593146166E-4,3.2956657743156677,0.016747964334545985,1.776037972627139,236]
["High","Q86U90","YrdC domain-containing protein, mitochondrial [OS=Homo sapiens]",11,2,4,2,279,29.3,8.57,12.78,"other biological processes","other membranes;mitochondrion;other cell component","nucleic acid binding activity;other molecular function","YRDC","ENSG00000196449","","","",292.8,293.9,309.4,300.9,293.6,284.5,1.0194539249146757,0.027796573001180155,0.47039728241599055,0.3275351959352101,0.660943311337782,0.17983578806195386,5557]
["High","Q86UK7-1","E3 ubiquitin-protein ligase ZNF598 [OS=Homo sapiens]",16,12,23,12,904,98.6,8.4,54.84,"protein metabolism;other metabolic processes","","translation activity;other molecular function","ZNF598","","","","",724.7,748.5,757,710.9,632.1,664,1.1112107623318386,0.1521324773329345,0.04014441332048005,1.396374884579692,0.14715848789028554,0.8322146833597944,2130]
["High","Q86UV5","Ubiquitin carboxyl-terminal hydrolase 48 [OS=Homo sapiens]",22,15,29,15,1035,119,6.05,61.63,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","USP48","ENSG00000090686","","Ub-specific processing proteases","",1301.4,1266.2,1302.2,1417,1478,1527.5,0.8750254381006218,-0.19260313635592483,0.005675304856020871,2.2460108048429217,0.046941504571833645,1.3284429944823555,944]
["High","Q86V21-1","acetoacetyl-CoA synthetase [OS=Homo sapiens]",19,14,38,14,672,75.1,6.24,75.73,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol","other molecular function","AACS","ENSG00000081760","","Synthesis of Ketone Bodies","Valine, leucine and isoleucine degradation; Butanoate metabolism; Metabolic pathways",1634.4,1754.2,1611.3,1380.7,1572.8,1473.1,1.1295124926580218,0.17570022734552185,0.05452689070865849,1.2633892664168285,0.17761617131965185,0.7505174957918469,2397]
["Medium","Q86VI4-1","Lysosomal-associated transmembrane protein 4B [OS=Homo sapiens]",2,1,5,1,370,41.1,8.97,1.63,"","","","","","","","",55.6,64.4,69.5,76,61.6,70.6,0.910182516810759,-0.13577222024096283,0.3460469286476868,0.4608650010028554,0.5481709107082854,0.26108401449894414,4929]
["High","Q86VP3-1","Phosphofurin acidic cluster sorting protein 2 [OS=Homo sapiens]",3,2,3,2,889,97.6,6.6,3.91,"cell organization and biogenesis;other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","PACS2","ENSG00000179364","","","",186.2,160.6,171.7,153.2,171.2,157.5,1.0759493670886078,0.10561018796059908,0.2548706908728989,0.5936801038168129,0.4533098757028689,0.3436048194002988,4390]
["High","Q86W42","THO complex subunit 6 homolog [OS=Homo sapiens]",34,8,18,8,341,37.5,7.43,38.82,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity","THOC6","ENSG00000131652","","mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","Nucleocytoplasmic transport",552.2,559.8,555.6,550.4,573.4,574,0.9822122747084463,-0.025893242879133867,0.28047091155196147,0.55211217400692,0.4813004126148825,0.31758376600539695,4550]
["High","Q86WA8","Lon protease homolog 2, peroxisomal [OS=Homo sapiens]",4,3,5,3,852,94.6,7.3,4.92,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","LONP2","ENSG00000102910","IL-18 signaling pathway","Peroxisomal protein import; Association of TriC/CCT with target proteins during biosynthesis","",175.9,210,232.6,193.3,181.2,184.4,1.1066380390051889,0.1461834202009384,0.3042895793731677,0.5167129201302391,0.5046501775160777,0.29700956964300074,4708]
["High","Q86WP2-1","Vasculin [OS=Homo sapiens]",2,1,1,1,473,53.3,7.05,2.89,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","GPBP1","ENSG00000062194; ENSGGOG00000008390","","","",56.5,62.3,52.9,110.9,60.9,85.7,0.6667961165048544,-0.5846823929558089,0.1234203811919527,0.9086131165725322,0.29113786596579055,0.5359013056896155,3310]
["High","Q86X10-1","Ral GTPase-activating protein subunit beta [OS=Homo sapiens]",12,12,19,12,1494,166.7,6.79,32.52,"other biological processes","","enzyme regulator activity;other molecular function","RALGAPB","ENSG00000170471","","Translocation of SLC2A4 (GLUT4) to the plasma membrane","",372.5,349.6,368.5,370.4,327.4,349.8,1.0410462008400152,0.05803409576867697,0.3724296405903232,0.4289557620823384,0.5741225338063659,0.24099540712000225,5065]
["High","Q86X76","Deaminated glutathione amidase [OS=Homo sapiens]",37,9,18,9,327,35.9,7.74,42,"other metabolic processes","mitochondrion;other cell component","other molecular function","NIT1","ENSG00000158793","","","",1010.6,1078.4,1028.7,983.4,1049.6,1021.3,1.0207576204040205,0.029640337955473953,0.49098335623325734,0.30893322970710985,0.6786330404441978,0.1683649997848017,5649]
["High","Q86XP3-1","ATP-dependent RNA helicase DDX42 [OS=Homo sapiens]",43,29,100,29,938,102.9,7.02,237.53,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX42","ENSG00000198231","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",3614.2,3609.5,3655.1,3631.7,3675.6,3742.4,0.984533516747061,-0.02248777385785134,0.18178429568982,0.7404436381099083,0.37020651558323275,0.4315559419933167,3834]
["High","Q86Y37","CDK2-associated and cullin domain-containing protein 1 [OS=Homo sapiens]",20,6,10,6,369,41,5.19,30.34,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","","other molecular function","CACUL1","ENSG00000151893","","","",253.3,223.3,247.3,237.3,232.2,268.4,0.981027239463342,-0.02763489963235669,0.764618376865517,0.11655526834238897,0.8697756827747606,0.06059273852440262,6864]
["High","Q86Y91","Kinesin-like protein KIF18B [OS=Homo sapiens]",2,2,2,2,864,94.2,8.79,4.48,"","","","","","","","",201.2,182.8,199.4,182.2,169.1,175.3,1.1078617546524878,0.14777786485211503,0.0532321807767612,1.273825741606442,0.17507871419753643,0.7567666515663789,2374]
["Low","Q86YF9","Zinc finger protein DZIP1 [OS=Homo sapiens]",1,1,1,1,867,98.6,6.15,0,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DZIP1","ENSG00000134874","","Hedgehog 'on' state","",62.5,62.8,49.3,64.3,56.6,67.4,0.9272437599575144,-0.10897944098478853,0.4521331740371103,0.3447336266248557,0.6446778347117891,0.19065726142817266,5476]
["High","Q86YS3","rab11 family-interacting protein 4 [OS=Homo sapiens]",3,2,2,1,637,71.9,4.87,2.45,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB11FIP4","ENSG00000131242","","","Endocytosis",22.9,14.3,15.4,13.4,20.9,13.9,1.091286307053942,0.1260296530623409,0.7066998266061949,0.15076501524248984,0.8345299827799713,0.0785580554832643,6612]
["High","Q86YZ3","Hornerin [OS=Homo sapiens]",7,5,10,5,2850,282.2,10.04,25.5,"cell organization and biogenesis;developmental processes","non-structural extracellular;plasma membrane;other cytoplasmic organelle;other cell component","other molecular function","HRNR","ENSG00000197915","","Neutrophil degranulation","",336.8,327.7,234.3,404.9,300.6,498.3,0.7466356537630835,-0.42152369222142144,0.19736809262236318,0.7047230559120079,0.3887613691209414,0.41031689706661023,3964]
["High","Q8IUD2-1","ELKS/Rab6-interacting/CAST family member 1 [OS=Homo sapiens]",41,43,115,37,1116,128,5.97,231.63,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","ERC1","ENSG00000082805","","","NF-kappa B signaling pathway",4645.3,3993,4456.8,4746.3,4404.1,4335.1,0.9710503874531903,-0.04238193637700151,0.6044711001419134,0.21862445799415028,0.7639544107976788,0.11693255730094675,6178]
["Low","Q8IUM7","Neuronal pas domain-containing protein 4 [OS=Homo sapiens]",2,1,1,1,802,87.1,4.64,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NPAS4","ENSG00000174576","Orexin receptor pathway","","",24.6,23.6,25.1,26.7,17.4,19.7,1.1489028213166146,0.20025677436894274,0.3259876253215898,0.48679888568835694,0.5270887095694705,0.27811628643006797,4829]
["High","Q8IV08","Phospholipase D3 [OS=Homo sapiens]",12,5,19,5,490,54.7,6.47,34.28,"DNA metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","PLD3","ENSG00000105223","","Role of phospholipids in phagocytosis; Synthesis of PG","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways",597.7,671.9,582.3,480.3,546.2,514.8,1.201518198922987,0.26485850056690624,0.036798038567277286,1.434175329753394,0.1398146399675431,0.8544473513068465,2055]
["High","Q8IVD9","NudC domain-containing protein 3 [OS=Homo sapiens]",56,15,49,15,361,40.8,5.25,78.44,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","other molecular function","NUDCD3","ENSG00000015676","","","",1170.8,1211.4,1231.2,1055.4,1010.5,1009.6,1.1748983905056085,0.23253599266060077,1.5434137107148479E-3,2.8115176460704157,0.026140941981044538,1.5826787668014284,461]
["High","Q8IVL5","Prolyl 3-hydroxylase 2 [OS=Homo sapiens]",8,5,9,4,708,80.9,5.71,16.09,"protein metabolism;other metabolic processes;other biological processes","extracellular matrix;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","P3H2","ENSG00000090530","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",125.4,135.3,120.5,123.7,137,138.5,0.9549098196392787,-0.06656360142731846,0.40214683939130536,0.3956153402159699,0.6008347726688312,0.22124494094864136,5226]
["Medium","Q8IVV7","Glucose-induced degradation protein 4 homolog [OS=Homo sapiens]",4,1,1,1,300,33.5,9.16,2.55,"protein metabolism;other metabolic processes","other cell component","other molecular function","GID4","ENSG00000141034","Ciliary landscape","","",23,32.6,29.9,29.1,39.1,41.4,0.7801094890510949,-0.3582514731872665,0.1650448078424986,0.7823981336227979,0.3496120074970778,0.45641365984721743,3686]
["Medium","Q8IWB1","Inositol 1,4,5-trisphosphate receptor-interacting protein [OS=Homo sapiens]",1,1,1,1,547,62,5.88,2.41,"other biological processes","plasma membrane;other membranes;nucleus","enzyme regulator activity","ITPRIP","ENSG00000148841","","","",65.1,78.8,68.5,83.1,68.2,91.6,{"$f":"AVERAGE(T4482:V4482)/AVERAGE(W4482:Y4482)","v":0.8744339234252778},{"$f":"LOG(Z4482,2)","v":-0.1935787238317115},{"$f":"TTEST(T4482:V4482,W4482:Y4482,2,2)","v":0.27180874774111347},{"$f":"-LOG10(AB4482)","v":0.5657365702872623},{"$f":"AB4482*7808/AF4482","v":0.4716183783028031},{"$f":"-LOG10(AD4482)","v":0.3264092794039706},4500]
["Medium","Q8IWE2","Protein Noxp20 [OS=Homo sapiens]",4,1,1,1,563,60.7,4.68,0,"","cytosol;ER/Golgi;nucleus","","FAM114A1","ENSG00000197712","","","",18.5,28.5,19.4,26.3,33.9,29.3,0.7418994413407822,-0.43070444080469383,0.11846421387796938,0.9264128231774269,0.28329818743007196,0.5477562041298842,3265]
["High","Q8IWR0","Zinc finger CCCH domain-containing protein 7A [OS=Homo sapiens]",19,17,27,17,971,110.5,7.3,67.19,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZC3H7A","ENSG00000122299","","","",1200.4,1216,1188.5,1347.5,1298.3,1384.9,0.8943607810057806,-0.16107116955177647,0.005712754945406271,2.2431544050555745,0.04710157403773196,1.3269645794002125,947]
["Low","Q8IWV2","Contactin-4 [OS=Homo sapiens]",1,1,2,1,1026,113.4,7.47,4.22,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","other molecular function","CNTN4","ENSG00000144619","","Post-translational modification: synthesis of GPI-anchored proteins","",187.1,211.9,160.3,180,196.6,173.2,1.0172790105492906,0.024715423472627576,0.8566451656542438,0.06719903164700727,0.9235964448257851,0.0345177474693647,7242]
["High","Q8IWZ6-1","Bardet-Biedl syndrome 7 protein [OS=Homo sapiens]",2,1,1,1,715,80.3,6.05,2.13,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BBS7","ENSG00000138686; ENSGGOG00000002169","Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","BBSome-mediated cargo-targeting to cilium","",23.9,26.1,32.1,35.3,27.4,37.7,0.8177290836653385,-0.2903051421729675,0.19835322177018253,0.702560741065057,0.38962061775637363,0.40935806939891056,3975]
["Medium","Q8IX21","SMC5-SMC6 complex localization factor protein 2 [OS=Homo sapiens]",1,1,1,1,1173,131.8,8.97,2.07,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","SLF2","ENSG00000119906","","","",73.4,78.1,74.7,73.5,93.5,64.2,0.9783737024221453,-0.03154246851085843,0.8583235666826858,0.06634896304336314,0.9245124029050091,0.03408725813696263,7249]
["High","Q8IXI1","Mitochondrial Rho GTPase 2 [OS=Homo sapiens]",27,10,32,9,618,68.1,5.86,88.53,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion","other molecular function","RHOT2","ENSG00000140983","","RHOT2 GTPase cycle","Mitophagy",863.9,976,976.2,965.8,941.3,985.4,0.9735868625756269,-0.038618394198980006,0.5543694670684569,0.2562006973155249,0.7280936583465957,0.13781275161159995,5945]
["Medium","Q8IXQ4","GPALPP motifs-containing protein 1 [OS=Homo sapiens]",2,1,2,1,340,38.1,5.41,2.83,"","","","GPALPP1","ENSG00000133114","","","",176.5,133.7,129.2,237,157.6,103.5,0.8821521782774544,-0.18090054124931068,0.6625670382707689,0.17877017342416235,0.8054372465854216,0.09396829077962776,6423]
["High","Q8IXU6-1","Solute carrier family 35 member f2 [OS=Homo sapiens]",10,2,5,2,374,41.2,6.21,10.53,"transport","other membranes","transporter activity","SLC35F2","ENSG00000110660","","","",157.8,179.4,175.6,197.6,187.2,176.1,0.9142449634515958,-0.12934732106304375,0.15296936989391174,0.815395522239848,0.33428067174129944,0.4758887337836526,3573]
["Medium","Q8IY26","Phospholipid phosphatase 6 [OS=Homo sapiens]",3,1,2,1,295,32.2,9.99,1.67,"other metabolic processes","plasma membrane;other membranes","other molecular function","PLPP6","ENSG00000205808","","Cholesterol biosynthesis","",27.4,27.3,26.4,31.4,28.7,31.1,0.8892543859649124,-0.16933190994746855,0.02096490290753604,1.6785071445563335,0.0981967377936661,1.0079029397257036,1667]
["High","Q8IY67-2","Isoform 2 of Ribonucleoprotein PTB-binding 1 [OS=Homo sapiens]",24,11,49,11,739,77.8,8.84,96.33,"","","","RAVER1","","","","",1441.2,1389.3,1489.2,1538,1517.6,1585.7,0.9307090685799235,-0.10359783033783569,0.03820780760390983,1.4178478817787736,0.14294516615779967,0.8448305261855923,2087]
["High","Q8IYB7","DIS3-like exonuclease 2 [OS=Homo sapiens]",20,15,30,15,885,99.2,6.1,63.11,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","other cell component","nucleic acid binding activity;other molecular function","DIS3L2","ENSG00000144535","","","",1671.5,1563.4,1611.4,1630.2,1574,1626.4,1.0032501138574919,4.681319847416909E-3,0.8918902851996394,0.0496885665464921,0.9428485441157304,0.02555806520281664,7386]
["High","Q8IYS1","Peptidase M20 domain-containing protein 2 [OS=Homo sapiens]",6,2,2,2,436,47.7,5.85,0,"protein metabolism;other biological processes","nucleus","other molecular function","PM20D2","ENSG00000146281","","","",41.8,38.3,46.9,37.3,43.1,43.6,1.0241935483870968,0.03448837638529061,0.7711550550948828,0.11285829016991611,0.8732673923394989,0.058852756023149266,6895]
["High","Q8IYS2-1","Uncharacterized protein KIAA2013 [OS=Homo sapiens]",10,5,6,5,634,69.1,8.19,19.27,"","other membranes","","KIAA2013","ENSG00000116685","","","",190,209.6,202.6,172.1,161.6,162.7,1.2131345688960518,0.2787395925943211,0.006015599145198902,2.220721111051441,0.048825153976832666,1.3113563784306186,962]
["High","Q8IZ40","REST corepressor 2 [OS=Homo sapiens]",37,15,40,15,523,58,9.01,101.75,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","RCOR2","ENSG00000167771","","","",1306.2,1237.6,1323.9,1526.5,1500.2,1435.3,0.8668086060062753,-0.20621461775833655,6.3233994029443024E-3,2.1990493861107736,0.04997277584836955,1.3012665260397664,988]
["Medium","Q8IZE3","Protein-associating with the carboxyl-terminal domain of ezrin [OS=Homo sapiens]",1,1,1,1,742,82.8,5.05,2.05,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","SCYL3","ENSG00000000457","","","",162.4,143.9,133,124.2,128.2,132.2,1.1422256890275613,0.19184773675286457,0.10946278510250677,0.9607335061363008,0.26995749402412283,0.5687046120040026,3166]
["High","Q8IZQ5","Selenoprotein H [OS=Homo sapiens]",34,4,10,4,122,13.4,9.74,17.95,"","ER/Golgi","","SELENOH","ENSG00000211450","Selenium micronutrient network","","",439,430.1,408.5,422.3,346.6,368.4,1.123362349424074,0.1678233555194317,0.12605364827426271,0.8994445803528496,0.29503204008556455,0.5301308176599152,3336]
["High","Q8IZT6-1","Abnormal spindle-like microcephaly-associated protein [OS=Homo sapiens]",3,9,12,9,3477,409.5,10.45,16.43,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","ASPM","ENSG00000066279","","","",355.9,398.6,389.9,274.1,273.4,294.6,1.3589834936468355,0.44252793308950256,2.4115625616980773E-3,2.617701466958843,0.030767124970161094,1.5119130844457689,612]
["Medium","Q8N0Z8","tRNA pseudouridine synthase-like 1 [OS=Homo sapiens]",4,1,1,1,303,33.2,9.85,2.27,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","PUSL1","ENSG00000169972","","","",75.6,70.6,91.3,92.4,78.3,77.2,0.9580475998386447,-0.06183075798104949,0.6844474472634212,0.16465989192690275,0.8195316160455134,0.08643428747572691,6521]
["Medium","Q8N118","Cytochrome P450 4X1 [OS=Homo sapiens]",1,1,1,1,509,58.8,8.48,0,"","other membranes;ER/Golgi","other molecular function","CYP4X1","ENSG00000186377","Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II","","Serotonergic synapse",24.8,29.9,20.1,25.4,23.9,28.8,0.9577464788732396,-0.0622842782543424,0.7467945715653248,0.1267988475893134,0.8600253709118078,0.06548873679774132,6780]
["High","Q8N1G1","RNA exonuclease 1 homolog [OS=Homo sapiens]",6,6,6,6,1221,131.4,8.95,10.33,"other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","REXO1","ENSG00000079313","","","Ribosome biogenesis in eukaryotes",326.1,337.7,334.5,321.6,303.7,325.8,1.0496267479760277,0.0698763901988503,0.10746754574853243,0.9687226690539609,0.26714632193713506,0.5732508007938303,3141]
["High","Q8N257","Histone H2B type 3-B [OS=Homo sapiens]",58,9,328,1,126,13.9,10.32,686.55,"cell organization and biogenesis","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","H2BU1","ENSG00000196890; ENSG00000285449","","Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Assembly of the ORC complex at the origin of replication; HATs acetylate histones; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Amyloid fiber formation; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Meiotic synapsis; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; HCMV Early Events; HCMV Late Events; HDACs deacetylate histones","Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis; Systemic lupus erythematosus",814.1,882.3,786.7,789.6,788.5,748.9,1.0670820799312422,0.09367115250287468,0.17302627369941093,0.761887945100703,0.35959253261778024,0.44418933550545225,3757]
["High","Q8N2F6-1","Armadillo repeat-containing protein 10 [OS=Homo sapiens]",17,4,6,4,343,37.5,6.61,13.58,"other biological processes","other membranes;mitochondrion;ER/Golgi","other molecular function","ARMC10","ENSG00000170632","","","",300.7,342.6,295.3,278.3,306.4,278.9,1.0868457619268177,0.12014721700575752,0.22825251898714125,0.6415844209078855,0.4238277451252316,0.372810616383181,4205]
["High","Q8N339","Metallothionein-1M [OS=Homo sapiens]",36,2,12,1,61,6.1,7.69,19.87,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1M","ENSG00000205364","Zinc homeostasis","Metallothioneins bind metals","Mineral absorption",19.2,16.3,11.3,10.7,12.8,16.8,1.1612903225806452,0.21572869105543727,0.49924053747295527,0.30169015792891885,0.6851942549813386,0.16418628703805493,5689]
["High","Q8N3P4-1","Vacuolar protein sorting-associated protein 8 homolog [OS=Homo sapiens]",4,4,5,3,1428,161.7,5.64,6.06,"cell organization and biogenesis;transport","other cytoplasmic organelle","other molecular function","VPS8","ENSG00000156931","","","",15.2,20.2,14.5,17,15.7,17.2,0.9999999999999998,-3.2034265038149176E-16,1,0,1.0001280901754834,-5.5625293947690858E-5,7807]
["High","Q8N3X1","Formin-binding protein 4 [OS=Homo sapiens]",13,10,17,10,1017,110.2,4.74,30.6,"","nucleus","","FNBP4","ENSG00000109920; ENSG00000285182","","","",509.2,523.9,527,678.2,642.6,689.9,0.775898940667429,-0.36605933847040234,5.9548154903256369E-4,3.22513169056657,0.017678783022229114,1.7525476343976925,263]
["High","Q8N488","RING1 and YY1-binding protein [OS=Homo sapiens]",41,8,28,8,228,24.8,9.63,46.92,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RYBP","ENSG00000163602","","Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",596.4,603.5,749.3,602.2,531.6,574.6,1.1409505970498712,0.19023632455017384,0.21063382282734733,0.6764718900932807,0.40418503038484344,0.39341977528793054,4069]
["High","Q8N4C6","ninein [OS=Homo sapiens]",3,6,8,5,2090,243.1,5.03,7.68,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","NIN","ENSG00000100503","","","",80.5,89.6,92.9,97.9,89,88,0.9567115314659878,-0.06384410733328835,0.4604669759769726,0.33680151132002667,0.6514452162399351,0.18612210072665483,5519]
["High","Q8N4V1","Membrane magnesium transporter 1 [OS=Homo sapiens]",25,2,6,2,131,14.7,9.16,13.27,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity","MMGT1","ENSG00000169446","","Miscellaneous transport and binding events","",418.6,467.7,381.3,371.6,479.1,434,0.9866894994940452,-0.01933193930035698,0.8934849932737416,0.04891273738680572,0.9438953899988329,0.025076135006707048,7391]
["High","Q8N5A5-1","Zinc finger CCCH-type with G patch domain-containing protein [OS=Homo sapiens]",24,8,18,8,531,57.3,5.43,53.91,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZGPAT","ENSG00000197114","","","",866.2,890.1,857.2,710.7,775.6,706.9,1.1916377895312784,0.25294578055045575,4.5314108774071596E-3,2.3437665571762585,0.04167403548974688,1.3801344427615758,849]
["High","Q8N5D0-1","WD and tetratricopeptide repeats protein 1 [OS=Homo sapiens]",4,2,2,2,677,75.9,7.27,4.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","WDTC1","ENSCATG00000044454; ENSCSAG00000000989; ENSG00000142784; ENSMFAG00000040733; ENSMNEG00000041566; ENSPANG00000008666; ENSPPAG00000030849; ENSPPYG00000001668","","Neddylation","",57.4,68.3,52,56.3,67.2,78.1,0.8814484126984126,-0.18205195747123856,0.3708923849881765,0.43075208333778225,0.5728838263081468,0.24193343860616673,5055]
["High","Q8N5N7","39S ribosomal protein L50, mitochondrial [OS=Homo sapiens]",21,2,2,2,158,18.3,7.88,4.88,"","other membranes;mitochondrion;translational apparatus","","MRPL50","ENSG00000136897","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",27.1,36.2,27.4,34.9,25.9,20.6,1.1142506142506141,0.15607375626227524,0.5783349549178299,0.2378205578794359,0.7433151157199038,0.12882703549115035,6075]
["High","Q8N653","Leucine-zipper-like transcriptional regulator 1 [OS=Homo sapiens]",1,1,1,1,840,94.7,6.57,2.7,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LZTR1","ENSG00000099949","22q11.2 copy number variation syndrome","","",17.3,25.2,22.4,28.8,26.1,33.9,0.7308558558558559,-0.45234119835096737,0.07048236963478166,1.1519195032621552,0.20712319989024283,0.6837712530137973,2657]
["High","Q8N6G5-1","chondroitin sulfate N-acetylgalactosaminyltransferase 2 [OS=Homo sapiens]",4,2,2,2,542,62.5,5.73,4.97,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CSGALNACT2","ENSG00000169826; ENSPPAG00000040591; ENSPTRG00000002443","","Chondroitin sulfate biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",74.7,83.1,89.6,59.1,65,70.9,1.2687179487179487,0.3433713763393967,0.03359456114620378,1.4737310278299964,0.13115316671477956,0.8822212188353422,2000]
["High","Q8N720-1","zinc finger protein 655 [OS=Homo sapiens]",13,6,6,6,491,57.4,7.14,15.03,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF655","ENSG00000197343; ENSPPAG00000041610; ENSPTRG00000048790","Retinoblastoma gene in cancer","Generic Transcription Pathway","",293.8,308.2,272.3,428.1,373.7,403.3,0.7254999585096673,-0.46295256310106137,0.004276070684872372,2.368955124371515,0.040225975792148774,1.3954934120889535,830]
["High","Q8N8A6","ATP-dependent RNA helicase DDX51 [OS=Homo sapiens]",22,9,22,9,666,72.4,8.16,67.05,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DDX51","ENSG00000185163; ENSG00000288503","","","",453.1,445.7,497.4,477.6,513.7,495.3,0.9391900982106819,-0.09051089655188545,0.1918864595578121,0.7169556701149692,0.38298810742009126,0.41681471157189764,3912]
["Low","Q8N8K9","Uncharacterized protein KIAA1958 [OS=Homo sapiens]",1,1,1,1,716,79.2,6.83,2.28,"","","","KIAA1958","ENSG00000165185","","","",65.3,68.6,57.3,63.5,56.4,57,1.0808366308648953,0.11214847529029005,0.30471899762673227,0.5161004689566369,0.5048262112178072,0.2968581040576373,4713]
["High","Q8N983","39S ribosomal protein L43, mitochondrial [OS=Homo sapiens]",10,2,5,2,215,23.4,8.65,3.24,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL43","ENSG00000055950","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",143.8,161.5,128.3,156.8,149.8,133.1,0.9861269047077551,-0.020154775858775904,0.872532838501818,0.05921821902579464,0.9318474084286957,0.03065519827154599,7311]
["High","Q8N9N8","probable RNA-binding protein EIF1AD [OS=Homo sapiens]",27,4,8,4,165,19,5.21,14.52,"protein metabolism;other metabolic processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity","EIF1AD","ENSG00000175376","","","",156.8,142.7,143.2,172,141.2,133.1,0.991933676898947,-0.011684433153989282,0.9293653996428611,0.03181350037866676,0.9635486708818828,0.016126343321374876,7531]
["Medium","Q8N9V7","Testis- and ovary-specific PAZ domain-containing protein 1 [OS=Homo sapiens]",1,1,6,1,1692,190.8,7.87,1.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol","","TOPAZ1","ENSG00000173769","","","",289.9,312.1,222.8,217.6,333.9,242.4,1.0389217785615317,0.055087036408107054,0.8279328410947596,0.08200489017752888,0.9083180586297434,0.041762051345818875,7117]
["High","Q8NB49-1","Phospholipid-transporting ATPase IG [OS=Homo sapiens]",18,14,19,14,1132,129.4,6.67,40.15,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","ATP11C","ENSG00000101974","Complement system in neuronal development and plasticity","Ion transport by P-type ATPases","",620.7,626.3,611,642.1,697.6,686.1,0.917168526014414,-0.12474124731931355,0.032979827642491785,1.4817516183734385,0.12920546624815646,0.8887191124152908,1993]
["High","Q8NB90-1","Spermatogenesis-associated protein 5 [OS=Homo sapiens]",19,11,21,10,893,97.8,5.66,36.87,"developmental processes;other biological processes","cytoskeleton;mitochondrion;other cell component","other molecular function","SPATA5","ENSG00000145375","","","Ribosome biogenesis in eukaryotes",631.5,647.2,631.4,614.9,598.4,608.2,1.0486412297556957,0.06852117497484823,0.014200462736241494,1.8476975034675127,0.0789161658680239,1.102834023049976,1405]
["High","Q8NBJ7-1","Sulfatase-modifying factor 2 [OS=Homo sapiens]",25,7,25,7,301,33.8,8,50.27,"","ER/Golgi","other molecular function","SUMF2","ENSG00000129103","","Glycosphingolipid metabolism; The activation of arylsulfatases","",970.9,953.1,935.7,961.7,921.2,888,1.03204734923671,0.04550916159640013,0.2782037359614758,0.5556370422211856,0.47898892401040855,0.3196745289586644,4535]
["High","Q8NBN3-1","Transmembrane protein 87A [OS=Homo sapiens]",14,5,10,5,555,63.4,6.74,24.09,"transport","other membranes;cytosol;ER/Golgi","","TMEM87A","ENSG00000103978","","RHOA GTPase cycle","",218,199.2,206.1,228.6,225.7,230.9,0.9096614127262114,-0.13659843867311447,0.02227238111644286,1.6522333505253528,0.10253699985683128,0.9891193937874123,1696]
["High","Q8NBT2","kinetochore protein SPC24 [OS=Homo sapiens]",49,8,16,8,197,22.5,4.7,36.98,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","","SPC24","ENSG00000161888","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",524.5,496.5,527.4,590.9,533.3,533.5,0.9340652711588346,-0.09840472794280991,0.16617831856186627,0.7794256396564806,0.35077596954070067,0.4549701663132393,3699]
["High","Q8NC54","Keratinocyte-associated transmembrane protein 2 [OS=Homo sapiens]",5,1,1,1,265,29.2,5.08,2.85,"","other membranes","","KCT2","ENSG00000113583","","","",31.3,25.2,22,31.9,30.9,37.9,0.7795431976166833,-0.35929912422779514,0.10168787236862478,0.9927308393825657,0.258456675603588,0.5876122460834047,3072]
["High","Q8NC96","adaptin ear-binding coat-associated protein 1 [OS=Homo sapiens]",27,6,17,6,275,29.7,6.8,34.83,"transport","plasma membrane;other membranes;cytosol","","NECAP1","ENSG00000089818","","Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",714.8,741.1,691.4,911.2,894.2,878.3,0.8001266907627531,-0.32169964280717717,4.850661266329785E-4,3.314199052172581,0.016324984123923688,1.787147232404845,232]
["High","Q8NCH0","Carbohydrate sulfotransferase 14 [OS=Homo sapiens]",12,4,7,4,376,43,9.48,6.95,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST14","ENSG00000169105","Proteoglycan biosynthesis; Metapathway biotransformation Phase I and II","Dermatan sulfate biosynthesis; Defective CHST14 causes EDS, musculocontractural type","Glycosaminoglycan biosynthesis",33.3,33.2,40.2,48,45.2,47,0.7610556348074181,-0.39392617318619794,0.010464662326644579,1.9802747808982486,0.06724945139624763,1.1723112541739442,1215]
["High","Q8ND30","Liprin-beta-2 [OS=Homo sapiens]",13,8,17,6,876,98.5,6.27,36.09,"cell organization and biogenesis","cytosol;other cell component","other molecular function","PPFIBP2","ENSG00000166387","Ectoderm differentiation","Receptor-type tyrosine-protein phosphatases","",89,85.4,106.2,106,89.2,94.8,0.9675862068965518,-0.04753789128239751,0.7185234257339934,0.1435590681683609,0.8436437455836121,0.07384090881283009,6650]
["High","Q8ND76","cyclin-Y [OS=Homo sapiens]",7,2,3,1,341,39.3,7.2,7.6,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","enzyme regulator activity;other molecular function","CCNY","ENSG00000108100","","","",81.7,98.3,107.1,67.6,67.7,71.2,1.390314769975787,0.47541154890037407,0.023519988709578447,1.6285628910724703,0.10572485425698822,0.9758229048609336,1737]
["High","Q8NDX6","Zinc finger protein 740 [OS=Homo sapiens]",14,3,3,3,193,21.8,9.19,4.23,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF740","ENSG00000139651","","Generic Transcription Pathway","",146.4,165,171.3,208,217.9,205.1,0.7649762282091918,-0.3865131784253089,0.004202725557337083,2.3764689689823344,0.03987227357434744,1.399328999535969,823]
["High","Q8NE62","Choline dehydrogenase, mitochondrial [OS=Homo sapiens]",5,4,6,4,594,65.3,8.28,8.09,"other metabolic processes","other membranes;mitochondrion","other molecular function","CHDH","ENSG00000016391","Methionine de novo and salvage pathway; One-carbon metabolism and related pathways","Choline catabolism","Glycine, serine and threonine metabolism; Metabolic pathways",279.6,310,307.5,344.8,368.3,343.6,0.8489637550865904,-0.23622513295008143,0.013572617213576582,1.8673363990744043,0.07673786763476173,1.1149902729944001,1381]
["Medium","Q8NEE8","Tetratricopeptide repeat protein 16 [OS=Homo sapiens]",1,1,2,1,873,98.2,9.01,0,"","","","TTC16","ENSG00000167094","","","",114,100.8,95.7,114.6,99.5,97.3,0.9971098265895953,-0.004175675971193269,0.9707892785370065,0.012875028691491432,0.984917189035466,6.600283062612595E-3,7696]
["High","Q8NEN9","PDZ domain-containing protein 8 [OS=Homo sapiens]",9,7,10,7,1154,128.5,6.09,18.93,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PDZD8","ENSG00000165650","","","",204.3,190.5,220.8,171.7,191.7,175.9,1.1414796959020954,0.19090519781765028,0.07563149009056637,1.1212973430557558,0.21615324839939318,0.6652382334066154,2732]
["High","Q8NEY1","neuron navigator 1 [OS=Homo sapiens]",17,24,41,24,1877,202.3,8.07,87.32,"cell organization and biogenesis;developmental processes","cytoskeleton;other cell component","","NAV1","ENSG00000134369","","","",1491.5,1422.2,1532.3,2029.8,1783.8,1879.4,0.780959072545231,-0.35668115136415623,0.006101800005875448,2.214542031005002,0.04931972509925,1.3069793527618598,966]
["High","Q8NF99-1","Zinc finger protein 397 [OS=Homo sapiens]",11,4,7,2,534,61.1,7.27,9.32,"other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF397","ENSG00000186812","","","",42.6,59.6,44.6,49.7,48.6,51.5,0.9799732977303071,-0.029185655615538313,0.8628625659714138,0.0640583718321302,0.9268442585093959,0.03299323603066344,7269]
["High","Q8NFH3","Nucleoporin Nup43 [OS=Homo sapiens]",20,5,11,5,380,42.1,5.63,29.01,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;nucleus;other cell component","","NUP43","ENSG00000120253","","Separation of Sister Chromatids; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Transport of Ribonucleoproteins into the Host Nucleus; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transport of Mature mRNA derived from an Intron-Containing Transcript; tRNA processing in the nucleus; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis",276.4,266.5,238.7,264.5,251.8,237.5,1.0368798089678959,0.05224867230402846,0.5363672834207611,0.2705377204982173,0.7132077229137096,0.14678396274759598,5872]
["High","Q8NFP7","Diphosphoinositol polyphosphate phosphohydrolase 3-alpha [OS=Homo sapiens]",27,4,6,1,164,18.5,5.68,15.96,"other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT10","ENSG00000122824","","Synthesis of pyrophosphates in the cytosol","",47.2,54.8,53,57.4,62.3,59.4,0.8654383026242323,-0.2084971218243613,0.04085498385058292,1.3887549568358115,0.14871595053862538,0.8276424486979193,2145]
["High","Q8NFY9","Kelch repeat and BTB domain-containing protein 8 [OS=Homo sapiens]",5,3,4,3,601,68.8,6.29,7.76,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","","KBTBD8","ENSG00000163376","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",246,228.5,248.4,183.9,199.4,193,1.25438139857713,0.3269760707683209,3.1842565724253184E-3,2.4969919461167707,0.03429334526551295,1.4647901480291288,725]
["High","Q8NG48-1","protein Lines homolog 1 [OS=Homo sapiens]",2,2,7,1,757,85.8,6.52,9.69,"other biological processes","","","LINS1","ENSG00000140471","","","",89.8,102,101.5,93.4,65.3,84.2,1.207492795389049,0.2720145811210908,0.14126992230855756,0.8499502936779494,0.3167821807539395,0.4992392558006264,3482]
["High","Q8NHP6-1","motile sperm domain-containing protein 2 [OS=Homo sapiens]",20,7,12,7,518,59.7,5.96,23.2,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","MOSPD2","ENSG00000130150","","Neutrophil degranulation; RHOD GTPase cycle","",448.1,514.7,465.5,507.4,459.3,461.2,1.0002801316618812,4.0408796311786662E-4,0.9960626315844054,1.7133526442648587E-3,0.9988770905999278,4.8794736777256969E-4,7786]
["High","Q8NI36","WD repeat-containing protein 36 [OS=Homo sapiens]",15,13,37,13,951,105.3,7.53,67.35,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","WDR36","ENSG00000134987","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1412,1536.4,1480.9,1453,1615.3,1614,0.945966725754437,-0.08013865702388691,0.26296183517260086,0.580107278037503,0.46191361282962146,0.33543923868510006,4445]
["Medium","Q8TAD4-1","Zinc transporter 5 [OS=Homo sapiens]",1,1,1,1,765,84,7.31,2.25,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A5","ENSG00000145740","Zinc homeostasis","Insulin processing; Zinc efflux and compartmentalization by the SLC30 family","",62.3,62.6,55.5,50.5,69.4,57.8,1.015194147439505,0.021755657226703064,0.8874897450121233,0.05183665653808296,0.9404885897196877,0.02664646906824003,7368]
["High","Q8TAD7","Overexpressed in colon carcinoma 1 protein [OS=Homo sapiens]",19,1,1,1,63,6.4,6.57,2.01,"","","","OCC1","ENSG00000235162","","","",15.9,20.5,11.4,15.8,15,13.5,1.0790067720090293,0.10970391942573017,0.6892352950140279,0.16163249089123496,0.823244482709122,0.08447117119851759,6537]
["High","Q8TB52","F-box only protein 30 [OS=Homo sapiens]",5,3,4,3,745,82.3,5.4,12.41,"protein metabolism;other metabolic processes","cytosol","other molecular function","FBXO30","ENSG00000118496","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",143,145.9,139.2,163.7,138,148.4,0.9511219728949122,-0.07229772918863188,0.3954881739332422,0.4028664984427249,0.594984905986658,0.22549405163254735,5190]
["Medium","Q8TBC5","Zinc finger and SCAN domain-containing protein 18 [OS=Homo sapiens]",1,1,1,1,510,54.8,4.82,2.35,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZSCAN18","ENSG00000121413","","","",176.9,159.1,143.4,135.2,141.5,126.2,1.189873417721519,0.2508081035005346,0.07475296547970721,1.1263715740279192,0.2141126758861166,0.6693576208679385,2726]
["Medium","Q8TBF5-1","Phosphatidylinositol-glycan biosynthesis class X protein [OS=Homo sapiens]",7,1,1,1,258,28.8,6.33,0,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","","PIGX","ENSG00000163964","3q29 copy number variation syndrome","Synthesis of glycosylphosphatidylinositol (GPI)","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways",45.2,49.2,71.3,64.6,39,60.4,1.0103658536585365,0.014877787716005649,0.9625565486840182,0.016573746951909545,0.9821800224940949,0.0078089036485324,7652]
["High","Q8TC12","Retinol dehydrogenase 11 [OS=Homo sapiens]",17,5,11,5,318,35.4,8.82,21.05,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","RDH11","ENSG00000072042","","RA biosynthesis pathway; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision)","Retinol metabolism; Metabolic pathways; Biosynthesis of cofactors",614.3,639,542.2,470.2,571,534,1.1398552564753681,0.1888506366504667,0.15041207439361798,0.8227172991696483,0.3308218244691181,0.48040584756610694,3550]
["High","Q8TCA0-1","Leucine-rich repeat-containing protein 20 [OS=Homo sapiens]",6,1,1,1,184,20.5,6.55,3.47,"","","","LRRC20","ENSG00000172731; ENSPTRG00000002588","","","",25.6,29.5,40.5,25.8,32.7,22.4,1.1817058096415325,0.24087091555077067,0.41494481394027727,0.38200965893827904,0.6132669141104836,0.21235046496658297,5283]
["High","Q8TCG2","Phosphatidylinositol 4-kinase type 2-beta [OS=Homo sapiens]",17,8,10,7,481,54.7,5.97,18.49,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","kinase activity;other molecular function","PI4K2B","ENSG00000038210","","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane; Synthesis of PIPs at the early endosome membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",271.9,260.7,296,268.1,268.1,290.2,1.0026621490803485,3.8355661141474895E-3,0.9569147568604385,0.019126747984916155,0.9788537169613919,0.009282205707877815,7633]
["High","Q8TCZ2","CD99 antigen-like protein 2 [OS=Homo sapiens]",8,2,3,2,262,28,5.14,6.32,"cell adhesion","plasma membrane;other membranes","","CD99L2","ENSG00000102181","","Cell surface interactions at the vascular wall","Cell adhesion molecules; Leukocyte transendothelial migration",136,182.3,132.6,185.2,174.1,209.7,0.7924428822495606,-0.33562114255642356,0.10927456335059334,0.9614809202288997,0.26991957944999456,0.568765611409844,3161]
["Medium","Q8TD31-1","Coiled-coil alpha-helical rod protein 1 [OS=Homo sapiens]",1,1,1,1,782,88.6,5.95,1.83,"transport;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CCHCR1","ENSG00000204536; ENSG00000206355; ENSG00000206457; ENSG00000234114","","","",37.7,32.1,30.4,76.4,70.9,71.6,0.45774326176336233,-1.1273894459857374,1.4598675308290438E-4,3.835686550544378,0.010652939888516984,1.9725305235709523,107]
["High","Q8TD55","pleckstrin homology domain-containing family O member 2 [OS=Homo sapiens]",19,7,12,7,490,53.3,5.43,28.78,"","non-structural extracellular;other cell component","","PLEKHO2","ENSG00000241839","","Neutrophil degranulation","",503.3,475,460.4,524.8,384.4,415.1,1.0863852601374309,0.11953581062413755,0.4391888835944899,0.35734866094109247,0.6346819920610359,0.1974438238216528,5403]
["High","Q8TDJ6-1","DmX-like protein 2 [OS=Homo sapiens]",2,4,5,3,3036,339.4,6.38,7.05,"other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","DMXL2","ENSG00000104093","","","Lysosome",27.4,38.1,27.8,43.9,33,36.9,0.8198594024604569,-0.28655157145482335,0.22254833349407657,0.6525756534912607,0.4177061028658053,0.379129179459368,4160]
["High","Q8TDY2-1","RB1-inducible coiled-coil protein 1 [OS=Homo sapiens]",17,23,35,23,1594,183,5.41,54.38,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RB1CC1","ENSG00000023287","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Malignant pleural mesothelioma; Alzheimer's disease","Macroautophagy","Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",1299.8,1224.9,1308.6,1308.3,1293.6,1268.5,0.9904144274493594,-0.013895764323431833,0.691598342921408,0.16014605597207507,0.8245533457826163,0.08378124174224125,6549]
["High","Q8TE77","Protein phosphatase Slingshot homolog 3 [OS=Homo sapiens]",14,6,9,6,659,73,5.3,13.74,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SSH3","ENSG00000172830","Regulation of actin cytoskeleton","","Axon guidance; Regulation of actin cytoskeleton",271.7,275.7,287.1,322.9,317.1,280.7,0.9063755837949385,-0.14181909693768008,0.10919766198511661,0.9617866601462315,0.26981498252525016,0.5689339381059999,3160]
["High","Q8TEH3","DENN domain-containing protein 1A [OS=Homo sapiens]",16,11,18,11,1009,110.5,6.96,32.4,"transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DENND1A","ENSG00000119522","","RAB GEFs exchange GTP for GDP on RABs","",620.7,574,588.7,658.8,624.2,639,0.9278876170655568,-0.10797801380220126,0.05350603093416643,1.2715972637019124,0.17546202836370076,0.7558168544481568,2381]
["High","Q8TEU7","Rap guanine nucleotide exchange factor 6 [OS=Homo sapiens]",6,6,7,5,1601,179.3,6.4,13.78,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","RAPGEF6","ENSG00000158987","","","Rap1 signaling pathway; Tight junction",120.8,107.9,101.1,125.3,116.8,117.8,0.9163656571269797,-0.12600470348726048,0.19032109116090218,0.720513081039095,0.38054470673094093,0.41959431459377866,3905]
["High","Q8TF09","Dynein light chain roadblock-type 2 [OS=Homo sapiens]",13,1,2,1,96,10.8,7.5,4.85,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DYNLRB2","ENSG00000168589","Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome","Intraflagellar transport","Salmonella infection",93.3,75.5,80.4,112.1,92.8,84.3,0.8616874135546336,-0.21476348392711567,0.244833468282394,0.6111292152157851,0.4429239389130983,0.3536708465680228,4316]
["High","Q8TF46","DIS3-like exonuclease 1 [OS=Homo sapiens]",4,3,3,3,1054,120.7,6.54,4.64,"RNA metabolism OR transcription;other metabolic processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","DIS3L","ENSG00000166938","","","RNA degradation",107.3,103.7,105.3,108.8,104.1,119.6,0.9512781954887218,-0.07206078475852062,0.3150795759452861,0.5015797477042644,0.5160774761864472,0.28728509497267096,4767]
["Medium","Q8WTW4","GATOR complex protein NPRL2 [OS=Homo sapiens]",2,1,1,1,380,43.6,6.52,0,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;kinase activity","NPRL2","ENSG00000114388","22q11.2 copy number variation syndrome","Amino acids regulate mTORC1","mTOR signaling pathway",31,27.8,28.6,32.8,27.7,29.3,0.9732739420935413,-0.03908216524054837,0.6775074120395095,0.1690859491764344,0.8159768430054742,0.08832216612070283,6483]
["High","Q8WU90","Zinc finger CCCH domain-containing protein 15 [OS=Homo sapiens]",50,22,60,22,426,48.6,5.31,136.13,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","other molecular function","ZC3H15","ENSG00000065548","VEGFA-VEGFR2 signaling pathway","","",3334,3244.7,3167,3689.5,3288.6,3055.7,0.9712870497717716,-0.04203036867457386,0.6420009384511569,0.19246433709647212,0.7912775576048355,0.10167115165729686,6335]
["High","Q8WUD6-1","Cholinephosphotransferase 1 [OS=Homo sapiens]",4,1,1,1,406,45.1,6.92,2.1,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","CHPT1","ENSG00000111666","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids","Synthesis of PC","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways; Choline metabolism in cancer",12.6,8.6,11.6,13.7,11.3,17.3,0.7754137115839242,-0.3669618485018662,0.2091415768716681,0.6795596218403142,0.40250861035592417,0.39522482488600497,4057]
["High","Q8WUI4","histone deacetylase 7 [OS=Homo sapiens]",4,3,4,3,952,102.9,7.58,9.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","HDAC7","ENSG00000061273","MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling pathway; Ethanol effects on histone modifications; Gastrin signaling pathway","Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway","Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis",137.7,127.9,112.5,135.7,137.9,141.2,0.9115236258437801,-0.1336480448259914,0.17849217334407816,0.7483808223977267,0.36665795566181586,0.4357388873421951,3801]
["High","Q8WUN7","Ubiquitin domain-containing protein 2 [OS=Homo sapiens]",12,2,2,2,234,26.2,5.67,5.68,"","other cell component","","UBTD2","ENSG00000168246","","","",53.8,49.7,47.1,48.2,46.4,44.3,1.084233261339093,0.11667517069053583,0.15840781506567098,0.8002233962555367,0.341859651750348,0.46615215412069627,3618]
["High","Q8WUY8","N-acetyltransferase 14 [OS=Homo sapiens]",11,1,2,1,206,21.6,10.74,7.22,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus","nucleic acid binding activity;other molecular function","NAT14","ENSG00000090971","Metapathway biotransformation Phase I and II","","",11.6,14.6,11.6,14.7,17.3,16.1,0.7858627858627858,-0.34765065954896945,0.051641351342465176,1.2870024017097028,0.1728314064646241,0.7623773358448201,2333]
["High","Q8WV74","Nucleoside diphosphate-linked moiety X motif 8 [OS=Homo sapiens]",6,1,1,1,236,25.4,8.41,4.51,"other metabolic processes","mitochondrion","other molecular function","NUDT8","ENSG00000167799","","","",33.4,31.2,39,37,39.9,46.3,0.8409090909090908,-0.2499782530083476,0.1434935237869993,0.8431676992577816,0.32002211760322496,0.4948200053641788,3501]
["High","Q8WVD3-1","E3 ubiquitin-protein ligase RNF138 [OS=Homo sapiens]",8,2,2,2,245,28.2,6.93,2.4,"cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction","other cell component","nucleic acid binding activity;other molecular function","RNF138","ENSG00000134758; ENSGGOG00000027857; ENSPPYG00000009094; ENSPTRG00000009956","","Antigen processing: Ubiquitination & Proteasome degradation","",83,97.5,92.6,109.8,93.4,108.9,0.87504005126562,-0.19257904315392393,0.12918431190087595,0.8887902237137216,0.2993977759934816,0.5237514300362064,3369]
["Medium","Q8WVL7","ankyrin repeat domain-containing protein 49 [OS=Homo sapiens]",5,1,1,1,239,27.3,5.15,2.54,"other biological processes","nucleus","","ANKRD49","ENSG00000168876","","","",14.1,23.1,26.1,22,20.6,28.8,0.8865546218487396,-0.17371857460075826,0.5731402498517522,0.24173909132465154,0.7412753140371842,0.1300204625194891,6037]
["High","Q8WVQ1","Soluble calcium-activated nucleotidase 1 [OS=Homo sapiens]",9,3,5,3,401,44.8,6.09,12.48,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","CANT1","ENSG00000171302","Proteoglycan biosynthesis","Neutrophil degranulation","Purine metabolism; Pyrimidine metabolism; Metabolic pathways",237.2,245.5,245.7,193.6,224.7,224.9,1.1324626865671643,0.17946351579790984,0.057773565975140634,1.2382708255427093,0.1837458261237874,0.7357825173430611,2455]
["Medium","Q8WW35","Tctex1 domain-containing protein 2 [OS=Homo sapiens]",13,1,1,1,142,16.1,4.93,0,"cell organization and biogenesis;transport;other biological processes","cytoskeleton;other cell component","other molecular function","DYNLT2B","ENSG00000213123","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 3q29 copy number variation syndrome","Intraflagellar transport","",27.3,23.4,23.1,31.5,36.2,29.7,0.7577002053388091,-0.40030095602194593,0.02913552197186713,1.5355771969844718,0.1211988042388591,0.9165016649471827,1877]
["High","Q8WWM7-1","ataxin-2-like protein [OS=Homo sapiens]",30,26,79,25,1075,113.3,8.59,155.2,"cell organization and biogenesis;other biological processes","other membranes;cytosol;nucleus;other cell component","","ATXN2L","ENSG00000168488","16p11.2 distal deletion syndrome","","Amyotrophic lateral sclerosis; Spinocerebellar ataxia; Pathways of neurodegeneration",4037.6,3455.5,3768.6,4245.8,3577,3617.5,0.9843885212800365,-0.022700259916278925,0.8387181080707827,0.07638398038742567,0.914113761560116,0.038999752905784196,7164]
["High","Q8WX77","Insulin-like growth factor-binding protein-like 1 [OS=Homo sapiens]",3,1,4,1,278,29,7.93,5.24,"other biological processes","non-structural extracellular","other molecular function","IGFBPL1","ENSG00000137142","","","",196.4,190.9,203.3,246.3,226.6,220.3,0.8519907674552798,-0.23109029802621556,0.016530329048757987,1.7817185013809085,0.08587412455934955,1.0661376773091813,1503]
["High","Q8WXE1","ATR-interacting protein [OS=Homo sapiens]",8,3,17,3,791,85.8,6.32,5.94,"DNA metabolism;other metabolic processes;stress response;signal transduction","nucleus","other molecular function","ATRIP","ENSG00000164053","miRNA regulation of DNA damage response; ATR signaling; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Fanconi Anemia Pathway; Activation of ATR in response to replication stress; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA)","Fanconi anemia pathway",467.1,504.3,485.6,509.2,423.9,495.2,1.0200938178253869,0.028701842674380727,0.7540744527123406,0.12258577242488258,0.864710431308262,0.06312930194459018,6809]
["High","Q8WXF7","Atlastin-1 [OS=Homo sapiens]",9,4,5,3,558,63.5,6.18,6.09,"cell organization and biogenesis;developmental processes","other membranes;ER/Golgi;other cell component","other molecular function","ATL1","ENSG00000198513","","","",106.4,100.3,108.5,113.4,91.3,109.3,1.0038216560509554,5.5029756773869115E-3,0.9584701916278902,0.018421389111243223,0.9798029924365758,0.00886123848990689,7638]
["High","Q8WXW3","Progesterone-induced-blocking factor 1 [OS=Homo sapiens]",11,8,9,8,757,89.8,6.02,21.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding","PIBF1","ENSG00000083535","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","","",305.4,303.2,317.8,416.7,382.2,409.1,0.7668874172185429,-0.3829132962232049,1.1902351760210794E-3,2.924367218811516,0.02317545200591668,1.634971786773063,401]
["High","Q8WY22","BRI3-binding protein [OS=Homo sapiens]",10,2,3,2,251,27.8,9.44,9.3,"","other membranes;mitochondrion","","BRI3BP","ENSG00000184992","","","",154.6,150.5,160.1,139.8,138.7,142.1,1.10603899191631,0.14540224674143906,0.007336774064884317,2.134494854768054,0.054661767078832774,1.2623163327571263,1048]
["High","Q8WYL5-1","Protein phosphatase Slingshot homolog 1 [OS=Homo sapiens]",3,2,2,2,1049,115.4,6.25,0,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SSH1","ENSG00000084112","Regulation of actin cytoskeleton","","Axon guidance; Regulation of actin cytoskeleton",28,25.2,36.8,40.7,37.2,36.7,0.7853403141361256,-0.3486101375398679,0.09186800690202267,1.0368357056432853,0.24274294344872857,0.6148533862019241,2955]
["High","Q8WZA9","Immunity-related GTPase family Q protein [OS=Homo sapiens]",29,10,21,10,623,62.7,4.88,52.89,"","","other molecular function","IRGQ","ENSG00000167378","","","",362.7,357,361.1,361.6,339.8,330.9,1.0469824663373049,0.0662372818675469,0.15631721000927717,0.8059932049583919,0.33894050978962403,0.4698765216710418,3601]
["High","Q92503-1","SEC14-like protein 1 [OS=Homo sapiens]",12,6,8,6,715,81.2,6.43,13.9,"stress response;transport;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding","SEC14L1","ENSG00000129657","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","",370.3,390.5,357.1,389.2,420.5,402.8,0.921979381443299,-0.11719360738037787,0.07648694062543442,1.116412709924407,0.2172462831587457,0.6630476451092402,2749]
["High","Q92530","proteasome inhibitor PI31 subunit [OS=Homo sapiens]",9,1,7,1,271,29.8,5.74,13.62,"protein metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMF1","ENSG00000125818","","Regulation of expression of SLITs and ROBOs; Neddylation; Ub-specific processing proteases; Separation of Sister Chromatids; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; ER-Phagosome pathway; Downstream TCR signaling; UCH proteinases; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome",34.6,29.2,30.2,24.4,24,19.5,1.3843888070692192,0.4692491823202677,0.018967953273027,1.7219795288997295,0.0929703572854958,1.0316555000422256,1593]
["High","Q92542-1","Nicastrin [OS=Homo sapiens]",19,10,31,10,709,78.4,5.99,46.36,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","NCSTN","ENSG00000162736; ENSGGOG00000003518","Alzheimer's disease and miRNA effects; Notch signaling; Inclusion body myositis; Alzheimer's disease; Notch signaling pathway","Neutrophil degranulation; Amyloid fiber formation; Degradation of the extracellular matrix; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; Nuclear signaling by ERBB4; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3","Notch signaling pathway; Alzheimer disease",1115.1,1074.2,1101.6,1053.5,1139.7,1078.8,1.005776283618582,0.008309439927962597,0.8345669603565935,0.07853881255366713,0.9120082332350289,0.04000124102202081,7145]
["High","Q92574-1","Hamartin [OS=Homo sapiens]",21,18,32,18,1164,129.7,6.47,43.57,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TSC1","ENSG00000165699","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Glioblastoma signaling pathways; Nanoparticle triggered autophagic cell death; Wnt signaling pathway; BDNF-TrkB signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; CAMKK2 pathway; Malignant pleural mesothelioma","TP53 Regulates Metabolic Genes; Macroautophagy; TBC/RABGAPs; Energy dependent regulation of mTOR by LKB1-AMPK; Inhibition of TSC complex formation by PKB","Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Cellular senescence; Thermogenesis; Insulin signaling pathway; Human cytomegalovirus infection; Human papillomavirus infection; Herpes simplex virus 1 infection; Choline metabolism in cancer",1162.5,1183.9,1209.1,1176.2,1158.6,1158.5,1.0178055134113875,0.025461911469725235,0.2311323166555172,0.6361393277188829,0.42653772830212205,0.3700425483915422,4231]
["High","Q92581-1","Sodium/hydrogen exchanger 6 [OS=Homo sapiens]",2,1,1,1,669,74.1,6.48,3.74,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","SLC9A6","ENSG00000198689","","Sodium/Proton exchangers; Defective SLC9A6 causes  X-linked, syndromic mental retardation,, Christianson type (MRXSCH)","Cardiac muscle contraction",58.2,72.4,47.8,52.6,55.2,47.4,1.1494845360824741,0.20098705773317693,0.3601358417147564,0.44353365429009683,0.561938579558117,0.2503111506528438,5004]
["High","Q92613","protein jade-3 [OS=Homo sapiens]",4,3,7,3,823,93.7,7.18,2.9,"protein metabolism;other metabolic processes","nucleus","other molecular function","JADE3","ENSG00000102221","","HATs acetylate histones","",102.4,98.5,104.1,104.6,113.3,110,0.9301616346447088,-0.10444665905544978,0.06537903070667814,1.1845615224503812,0.19824445505155064,0.7027989511689555,2575]
["High","Q92618","Zinc finger protein 516 [OS=Homo sapiens]",9,10,12,10,1163,124.2,8.72,24.97,"stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF516","ENSG00000101493","Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects","","Thermogenesis",632,598,602.5,642.1,618.4,656.4,0.9559705774949137,-0.06496187872672725,0.1413167872807859,0.8498062444475415,0.3167053602435064,0.49934458612453175,3484]
["High","Q92665","28S ribosomal protein S31, mitochondrial [OS=Homo sapiens]",26,8,14,8,395,45.3,9.29,34.3,"","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS31","ENSG00000102738","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",503.8,499.5,448.7,606.4,502.7,563.2,0.8682652634096754,-0.2037922276308232,0.10312446656950722,0.9866382849052298,0.26032843031836805,0.5844784002497733,3093]
["High","Q92729-1","Receptor-type tyrosine-protein phosphatase U [OS=Homo sapiens]",1,1,1,1,1446,162.3,6.92,2.6,"cell adhesion;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PTPRU","ENSG00000060656","EPO receptor signaling","Signaling by SCF-KIT","",46.9,38.3,39.1,42.7,47.5,47.2,0.9046579330422123,-0.1445557077656155,0.2381732992151798,0.6231069273766651,0.43480409639282763,0.3617063729748407,4277]
["High","Q92738-1","USP6 N-terminal-like protein [OS=Homo sapiens]",4,2,2,2,828,94,9.07,7.22,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","USP6NL","ENSG00000148429","EGF/EGFR signaling pathway","Retrograde transport at the Trans-Golgi-Network","",119.8,105.6,114.7,101.5,120.4,117.2,{"$f":"AVERAGE(T5186:V5186)/AVERAGE(W5186:Y5186)","v":1.0029489826010025},{"$f":"LOG(Z5186,2)","v":0.004248221682410844},{"$f":"TTEST(T5186:V5186,W5186:Y5186,2,2)","v":0.9651301078024089},{"$f":"-LOG10(AB5186)","v":0.01541413609477541},{"$f":"AB5186*7808/AF5186","v":0.9832640764250011},{"$f":"-LOG10(AD5186)","v":0.007329827506628025},7664]
["High","Q92793-1","CREB-binding protein [OS=Homo sapiens]",10,18,33,12,2442,265.2,8.53,61.8,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CREBBP","ENSG00000005339","Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL-6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RORA activates gene expression; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; SUMOylation of transcription cofactors; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; Formation of the beta-catenin:TCF transactivating complex; Estrogen-dependent gene expression; HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production","cAMP signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Cell cycle; Wnt signaling pathway; Notch signaling pathway; TGF-beta signaling pathway; Adherens junction; JAK-STAT signaling pathway; Long-term potentiation; Melanogenesis; Thyroid hormone signaling pathway; Glucagon signaling pathway; Growth hormone synthesis, secretion and action; Huntington disease; Tuberculosis; Hepatitis B; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Renal cell carcinoma; Prostate cancer",1021.7,1018.8,1007.5,1195.9,1197.2,1255.1,0.8354805109369002,-0.25932191962617723,5.6074784070381657E-4,3.2512323900984907,0.017102809141466405,1.7669325507517046,256]
["High","Q92802-1","NEDD4-binding protein 2-like 2 [OS=Homo sapiens]",4,3,3,3,583,67.4,6.39,2.14,"developmental processes;other biological processes","nucleus;other cell component","other molecular function","N4BP2L2","ENSG00000244754","","","",173.6,174.9,158.2,273.1,266,268.9,0.6271039603960397,-0.673223464116615,6.288449267117327E-5,4.201456438460379,0.008049215061910179,2.0942464688125115,61]
["High","Q92834","X-linked retinitis pigmentosa GTPase regulator [OS=Homo sapiens]",3,2,2,1,1020,113.3,4.86,2.16,"cell organization and biogenesis;transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity","RPGR","ENSG00000156313","Ciliary landscape","","",25,23.4,25.1,22.3,24,18.2,1.1395348837209303,0.18844508941311033,0.1722824077345306,0.7637590673801037,0.35852373123433234,0.4454820924284951,3752]
["High","Q92882","osteoclast-stimulating factor 1 [OS=Homo sapiens]",21,3,6,3,214,23.8,5.68,13.39,"signal transduction;other biological processes","other cell component","other molecular function","OSTF1","ENSG00000134996","","Neutrophil degranulation","",189.8,186.5,178.4,145.3,131.7,140.7,1.3279865932487434,0.40924058196255964,9.5231813250224026E-4,3.021217946457764,0.020712256207736746,1.683772590377448,359]
["High","Q92888-1","Rho guanine nucleotide exchange factor 1 [OS=Homo sapiens]",18,13,24,13,912,102.4,5.66,48.85,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","ARHGEF1","ENSG00000076928","G protein signaling pathways; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway","G alpha (12/13) signalling events; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK","Vascular smooth muscle contraction; Platelet activation; Regulation of actin cytoskeleton; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis",824.3,773.2,831.3,884,874.6,878.6,0.9209767935689368,-0.11876329060638002,0.01990794210999,1.7009736308046697,0.09583305301775705,1.0184846760211717,1622]
["High","Q92922","SWI/SNF complex subunit SMARCC1 [OS=Homo sapiens]",47,52,215,42,1105,122.8,5.76,457.93,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","SMARCC1","ENSG00000173473","Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",10132.4,9246.6,10328.9,10931.7,10419,10833.6,0.9230556513579602,-0.11551046379008867,0.08837814248591608,1.0536551305921715,0.23745923486924733,0.6244109358955388,2906]
["High","Q92993-1","Histone acetyltransferase KAT5 [OS=Homo sapiens]",7,4,4,4,513,58.5,8.48,8.03,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","HTATIP; KAT5","ENSANAG00000035412; ENSCANG00000040731; ENSCCAG00000033565; ENSG00000172977; ENSGGOG00000003283; ENSMLEG00000035009; ENSMNEG00000035393; ENSPANG00000021813; ENSPPAG00000042045; ENSPPYG00000003052; ENSPTRG00000003890; ENSRBIG00000038205; ENSRROG00000042827; ENSSBOG00000020725","Androgen receptor signaling pathway; ATM signaling in development and disease ; Joubert syndrome; Gastrin signaling pathway; Androgen receptor signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex; Estrogen-dependent gene expression; DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; HDR through Single Strand Annealing (SSA); Sensing of DNA Double Strand Breaks","Spinocerebellar ataxia; Human T-cell leukemia virus 1 infection",97.8,95,87.9,117.4,109.6,105.9,0.8431961550015021,-0.2460598066277384,0.017925804906981604,1.7465213344711918,0.08995159685971231,1.0459911224662266,1556]
["High","Q92995","Ubiquitin carboxyl-terminal hydrolase 13 [OS=Homo sapiens]",22,14,33,13,863,97.3,5.53,55.16,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","USP13","ENSG00000058056","","Ub-specific processing proteases; Regulation of PTEN stability and activity","",683,720.4,713.4,784.4,796.4,836.4,0.8757239781565449,-0.1914518804209944,0.006771154475126247,2.1693372782230074,0.052087856297325846,1.2832635158136039,1015]
["High","Q93073-1","Selenocysteine insertion sequence-binding protein 2-like [OS=Homo sapiens]",2,2,2,2,1101,121.7,6.04,5.06,"protein metabolism;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","KIAA0256; SECISBP2L","ENSG00000138593; ENSGGOG00000007289","Thyroid hormones production and peripheral downstream signaling effects","","",85.6,75.5,72.6,81.9,77.4,68,1.0281566212054551,0.04006004996497731,0.7264078281451706,0.13881948428056645,0.8476748351752342,0.0717707095013619,6691]
["High","Q969E2-1","Secretory carrier-associated membrane protein 4 [OS=Homo sapiens]",12,3,7,3,229,25.7,8.82,13.33,"transport","other membranes;ER/Golgi;other cytoplasmic organelle","","SCAMP4","ENSG00000227500; ENSPPAG00000030995; ENSPTRG00000042465","","","",312.3,307.6,306.8,298.2,269.2,299.2,1.0693514885760447,0.09673613507692562,0.11530653968551449,0.9381460607123231,0.2786485490140815,0.5549432140713317,3231]
["High","Q969E8","pre-rRNA-processing protein TSR2 homolog [OS=Homo sapiens]",11,2,3,2,191,20.9,4.39,4.37,"RNA metabolism OR transcription;other metabolic processes","","","TSR2","ENSG00000158526","","","",71.8,88.2,92.6,73.6,70.5,73.7,1.1597796143250687,0.2138506850706452,0.1448561459990898,0.8390630736955287,0.321682817963849,0.4925721354386276,3516]
["High","Q969M3","Protein YIPF5 [OS=Homo sapiens]",5,1,2,1,257,28,4.36,5.15,"transport;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","","YIPF5","ENSG00000145817","","","",166.3,158.2,193,168.8,156.5,169.3,1.0463000404367164,0.06529662288411196,0.5369323437706706,0.27008043418531136,0.7138375174802308,0.14640063036963308,5873]
["High","Q969S9","Ribosome-releasing factor 2, mitochondrial [OS=Homo sapiens]",5,5,5,4,779,86.5,6.51,9.43,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","other molecular function","GFM2","ENSG00000164347","","Mitochondrial translation termination","",265.1,277.2,280.3,323.7,298.6,310.4,0.8819556127372146,-0.18122204556183816,0.01300828780518009,1.88577986298472,0.07479286537764812,1.1261398282705675,1358]
["High","Q969V3","Nicalin [OS=Homo sapiens]",19,9,35,9,563,62.9,6.89,107.04,"protein metabolism;other biological processes","other membranes;ER/Golgi;other cell component","translation activity;other molecular function","NCLN","ENSG00000125912","","","",819,885.6,838.5,860.9,869.7,899.1,0.9670684868996463,-0.04831003123308631,0.27590004069994895,0.5592482354549866,0.47607237962103893,0.3223270143375733,4525]
["High","Q969Z3-1","Mitochondrial amidoxime reducing component 2 [OS=Homo sapiens]",7,2,7,1,335,38,9.16,17.82,"other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;other cytoplasmic organelle","other molecular function","MTARC2","ENSG00000117791","","Phase I - Functionalization of compounds","",104.6,86.3,87.7,88.5,94.3,98.1,0.991812032751869,-0.01186136652514537,0.9119204913896538,0.04004302532948122,0.9534380284909504,0.020707529947886487,7468]
["High","Q96A54","adiponectin receptor protein 1 [OS=Homo sapiens]",8,2,2,2,375,42.6,7.02,4.36,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","ADIPOR1","ENSG00000159346","AMP-activated protein kinase (AMPK) signaling; Leptin and adiponectin; Nonalcoholic fatty liver disease","AMPK inhibits chREBP transcriptional activation activity","AMPK signaling pathway; Longevity regulating pathway; Adipocytokine signaling pathway; Non-alcoholic fatty liver disease; Alcoholic liver disease",36.4,33.1,38.2,33,32.3,34.3,1.0813253012048194,0.11280060247612675,0.1676396464298821,0.7756232638111895,0.3522417543930354,0.45315916447415827,3716]
["Medium","Q96A83","Collagen alpha-1(XXVI) chain [OS=Homo sapiens]",2,1,2,1,441,45.4,7.31,3.96,"other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","COL26A1","ENSG00000160963","","Collagen degradation; Collagen chain trimerization","Protein digestion and absorption",107.6,91.4,97.2,96.3,83.8,80.8,1.1353008815638177,0.18307469647139585,0.154230248350909,0.8118304420854004,0.33581421615278795,0.47390092265292905,3586]
["Medium","Q96AG3","Solute carrier family 25 member 46 [OS=Homo sapiens]",3,1,1,1,418,46.1,7.43,2.43,"cell organization and biogenesis","other membranes;mitochondrion","","SLC25A46","ENSG00000164209","","","",96.9,101,120,97.6,111.2,97.9,1.0365177698076293,0.05174484987095616,0.6800894342684451,0.1674339722124225,0.8168186898581786,0.08787433359326755,6501]
["Medium","Q96AN5-1","Transmembrane protein 143 [OS=Homo sapiens]",3,1,1,1,459,51.7,9.67,0,"","other membranes;mitochondrion","","TMEM143","ENSG00000161558","","","",18.4,24.3,22.2,17.9,22.6,21.1,1.0535714285714286,0.0752881273042372,0.6453835925087981,0.19018207979586918,0.7931929939097585,0.10062113047249555,6353]
["Medium","Q96AY2","crossover junction endonuclease EME1 [OS=Homo sapiens]",4,1,1,1,570,63.2,7.05,0,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EME1","ENSG00000154920","","Fanconi Anemia Pathway; Resolution of D-loop Structures through Holliday Junction Intermediates","Homologous recombination; Fanconi anemia pathway",14.2,17.4,14.4,17.3,22.3,18.2,0.795847750865052,-0.32943563155630345,0.10122188349806557,0.9947255857665509,0.25802822930228403,0.5883327779144881,3063]
["High","Q96B01","RAD51-associated protein 1 [OS=Homo sapiens]",13,4,8,4,352,38.4,9.11,14.53,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity","RAD51AP1","ENSG00000111247","","Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function","",403.2,441.6,412.7,793.7,739.3,709.5,0.5607580824972129,-0.8345495851137342,2.7090947127646474E-4,3.5671758113152947,0.013387728808396436,1.873293093611082,158]
["High","Q96BD8","Spindle and kinetochore-associated protein 1 [OS=Homo sapiens]",13,3,3,3,255,29.5,7.12,7.08,"cell cycle OR cell proliferation;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity","SKA1","ENSG00000154839; ENSG00000262634","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",204.4,185.6,162.3,201.7,169.8,174.6,1.0113532320087897,0.016286970596798966,0.9017054007377928,0.044935329123240636,0.9486008850661125,0.022916474477369476,7422]
["High","Q96BN8","Ubiquitin thioesterase otulin [OS=Homo sapiens]",33,12,29,12,352,40.2,5.47,26.38,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","OTULIN","ENSG00000154124","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TNFR1 signaling","",1108.8,1154.8,1119.9,1230,1167.7,1127.1,0.9599126191556968,-0.05902501160395353,0.2264118017114671,0.645100939300976,0.42241896003898094,0.3742565969716194,4185]
["High","Q96BR6-1","Zinc finger protein 669 [OS=Homo sapiens]",11,4,7,2,464,52.6,8.72,18.07,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF669","ENSG00000188295","","Generic Transcription Pathway","Herpes simplex virus 1 infection",219.3,203,221.7,141.4,125.3,170.4,1.4733470601692975,0.5590973102163105,0.008809412888498992,2.0550530345824614,0.06076315886342768,1.2163596567760786,1132]
["High","Q96BY7","autophagy-related protein 2 homolog B [OS=Homo sapiens]",2,4,6,4,2078,232.6,5.76,9.7,"cell organization and biogenesis;other metabolic processes;transport","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","ATG2B","ENSG00000066739","Alzheimer's disease and miRNA effects; Alzheimer's disease","","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",267.1,263,266.3,337.8,309,310.5,0.8319231171001777,-0.2654778882799653,0.004744189471894472,2.3238379745858144,0.04272506504792622,1.369317267403389,867]
["High","Q96C36","Pyrroline-5-carboxylate reductase 2 [OS=Homo sapiens]",25,7,29,6,320,33.6,7.77,64.53,"other metabolic processes;stress response","mitochondrion","other molecular function","PYCR2","ENSG00000143811","Metabolic reprogramming in colon cancer","Glutamate and glutamine metabolism","Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids",1323.3,1377.8,1273.8,1252.2,1351.1,1367.5,1.0010325375239244,1.4888682413432995E-3,0.9781454830593761,0.009596546244110047,0.9889110360905876,0.004842776423846213,7723]
["High","Q96C92-4","Isoform 4 of Serologically defined colon cancer antigen 3 [OS=Homo sapiens]",15,4,5,4,362,40,4.88,9.17,"","","","ENTR1","","","","",108.8,104.7,105.3,101.7,104.3,105.1,1.0247508839601414,0.035273234456089805,0.1925052743574163,0.7155573669713696,0.38373275011046887,0.41597113386060003,3917]
["Medium","Q96CN4","EVI5-like protein [OS=Homo sapiens]",1,1,1,1,794,91.3,5.34,1.95,"transport;other biological processes","","enzyme regulator activity;other molecular function","EVI5L","ENSG00000142459","","","",39.6,30.3,42.5,30.2,27.2,29.6,1.2919540229885058,0.36955472948483553,0.08934988463224768,1.0489060039150306,0.23883734995158842,0.6218977562299449,2921]
["High","Q96CS7-1","Pleckstrin homology domain-containing family B member 2 [OS=Homo sapiens]",14,3,5,3,222,24.7,5.39,7.1,"other biological processes","other membranes;other cytoplasmic organelle","other molecular function","PLEKHB2","ENSG00000115762","","","",366.5,403.7,382.6,413.4,427.2,403.3,0.9267626014952973,-0.10972826791153431,0.07671471071804878,1.115121348292458,0.21757662959917357,0.6623877550271529,2753]
["High","Q96CW6","Probable RNA polymerase II nuclear localization protein SLC7A6OS [OS=Homo sapiens]",42,7,10,7,309,35,4.6,22.52,"transport;developmental processes;other biological processes","nucleus;other cell component","","SLC7A6OS","ENSG00000103061","","","",314.3,317.9,357.8,312.9,349.2,337.2,0.990693485439808,-0.013489329541172879,0.868438217943476,0.061261072508336394,0.9298910594765031,0.03156792783263968,7292]
["High","Q96D71","RalBP1-associated Eps domain-containing protein 1 [OS=Homo sapiens]",12,8,9,8,796,86.6,5.69,18.76,"transport","plasma membrane;other membranes;cytosol","other molecular function","REPS1","ENSG00000135597","","Cargo recognition for clathrin-mediated endocytosis","",419.3,413.2,465.2,461.1,468.4,414.2,0.965766168043462,-0.050254169843177744,0.5515508220845173,0.2584144637606101,0.7261016386504656,0.13900258313530942,5931]
["High","Q96DE0","U8 snoRNA-decapping enzyme [OS=Homo sapiens]",25,5,13,4,195,21.3,6.89,32.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT16","ENSG00000198585","","Phosphate bond hydrolysis by NUDT proteins","Purine metabolism; Metabolic pathways; RNA degradation",479.8,507.1,506.9,520.1,482,515.3,0.9844470805324899,-0.02261443950236549,0.6282341775141043,0.20187844058631657,0.7827114182272421,0.10639833062765217,6267]
["High","Q96DM3","Uncharacterized protein C18orf8 [OS=Homo sapiens]",6,3,4,3,657,74.9,7.83,7.57,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle","","RMC1","ENSG00000141452","","","",80.9,78.4,87.5,81.5,78.9,68,1.0805604203152364,0.11177974378657503,0.282777574586435,0.5485550348310644,0.48324081907876654,0.315836388228134,4569]
["High","Q96DU9-1","Polyadenylate-binding protein 5 [OS=Homo sapiens]",5,2,14,1,382,43.3,9.51,32.73,"","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity","PABPC5","ENSANAG00000005063; ENSCCAG00000032154; ENSG00000174740; ENSGGOG00000007622; ENSNLEG00000035086; ENSPPYG00000020526; ENSPTRG00000022078","","","mRNA surveillance pathway; RNA degradation",87.5,101.5,82.9,78.3,70,79.9,1.1914986853637157,0.252777359736078,0.08447565842903457,1.0732684145162856,0.2311092995844085,0.6361825786362783,2854]
["High","Q96DZ1","Endoplasmic reticulum lectin 1 [OS=Homo sapiens]",10,4,8,4,483,54.8,6.28,15.24,"protein metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi","other molecular function","ERLEC1","ENSG00000068912","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis","Protein processing in endoplasmic reticulum",173.5,176.2,170.6,147.6,168.4,161.7,1.0891773079338496,0.1232388305054268,0.08862836625011268,1.0524272562818273,0.23780422119617864,0.6237804406090992,2910]
["High","Q96E52-1","Metalloendopeptidase OMA1, mitochondrial [OS=Homo sapiens]",6,3,4,3,524,60.1,9.25,7.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion","other molecular function","OMA1","ENSG00000162600","","Regulation of Apoptosis","Spinocerebellar ataxia",145.8,178.4,133.9,181.1,184.7,213.5,0.7907819782496117,-0.33864810215379865,0.0739062428110783,1.131318875490259,0.21309451398408397,0.6714277308447303,2708]
["High","Q96ED9-1","Protein Hook homolog 2 [OS=Homo sapiens]",13,8,8,8,719,83.2,5.47,19.23,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","HOOK2","ENSG00000095066","","","",298.2,269.7,319,311.8,295.8,306.8,0.969925634295713,-0.04405395701606471,0.575382765074897,0.24004315103966192,0.7419634400833686,0.12961749386009755,6055]
["High","Q96EK5","KIF1-binding protein [OS=Homo sapiens]",16,8,19,8,621,71.8,5.49,37.08,"transport;developmental processes;other biological processes","cytoskeleton;mitochondrion","cytoskeletal activity","KIFBP","ENSG00000198954","","","",878.5,802.7,842.3,766.6,773.7,827.3,1.0658472714985636,0.09200072474107363,0.148570475778006,0.8280674858691002,0.3279723706176621,0.4841627410252163,3537]
["High","Q96EP0-1","E3 ubiquitin-protein ligase RNF31 [OS=Homo sapiens]",18,12,18,12,1072,119.6,6.57,29.82,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RNF31","ENSG00000092098; ENSG00000285152","","Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway","Necroptosis; NOD-like receptor signaling pathway; Shigellosis",535.2,514.4,536.9,507.3,481,486.9,1.0754473969631237,0.10493696037566223,0.02611192212389781,1.583161158162595,0.11377337496841189,0.943959358830066,1792]
["High","Q96ES7","SAGA-associated factor 29 [OS=Homo sapiens]",29,5,6,5,293,33.2,8.1,10.71,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SGF29","ENSG00000176476","","HATs acetylate histones","",124.5,140.2,125.7,107.8,98.7,110.1,1.233101705622236,0.30229179742570483,0.015950470376071894,1.797226505163521,0.08420640479808611,1.074654874501778,1479]
["High","Q96EX3","Wd repeat-containing protein 34 [OS=Homo sapiens]",8,3,3,3,536,57.8,6.64,3.04,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","DYNC2I2","ENSG00000119333","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 3q29 copy number variation syndrome","Intraflagellar transport","",72.8,77,77.8,73.5,76,73.3,1.021543985637343,0.030751324966550215,0.4188974048305434,0.3778923301884722,0.6153811734556695,0.21085579438915228,5315]
["High","Q96F44-1","E3 ubiquitin-protein ligase TRIM11 [OS=Homo sapiens]",17,6,10,6,468,52.7,5.69,23.99,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM11","ENSG00000154370; ENSPPAG00000018913; ENSPTRG00000002071","","Antigen processing: Ubiquitination & Proteasome degradation","",430.1,465.5,462.6,412.1,380.6,375,1.163141217778539,0.21802626604632364,0.017214599972504702,1.7641030648415232,0.08819658568590336,1.0545482271864695,1524]
["High","Q96F46","Interleukin-17 receptor A [OS=Homo sapiens]",4,2,2,2,866,96.1,5.21,2.5,"stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","IL17RA","ENSG00000177663","IL-17 signaling pathway","Interleukin-17 signaling","Cytokine-cytokine receptor interaction; IL-17 signaling pathway; Alcoholic liver disease",15.8,11.8,13.1,14.6,8.2,13.1,1.1337047353760448,0.18104495044319593,0.5186042296672065,0.28516394550411966,0.7006855555012197,0.15447683531186732,5779]
["High","Q96FL9","Polypeptide N-acetylgalactosaminyltransferase 14 [OS=Homo sapiens]",8,3,5,3,552,64.3,7.72,6.62,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT14","ENSG00000158089","","O-linked glycosylation of mucins","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways",98.9,98,101,127.1,128,119.5,0.7952482648158035,-0.3305227759935155,8.4141705928730771E-4,3.074988687138088,0.019552929758676483,1.7087881598692969,336]
["High","Q96FW1","Ubiquitin thioesterase otub1 [OS=Homo sapiens]",50,10,66,10,271,31.3,4.94,168.33,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","OTUB1","ENSG00000167770","","Ub-specific processing proteases; Ovarian tumor domain proteases","",2576.6,2681.5,2503.5,2256.9,2628.6,2393,1.066373565982002,0.09271292344336242,0.25150857553197503,0.5994472024858958,0.4497890420874166,0.34699112920038083,4366]
["High","Q96G21","U3 small nucleolar ribonucleoprotein protein IMP4 [OS=Homo sapiens]",34,8,17,8,291,33.7,9.47,36.47,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","IMP4","ENSG00000136718","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",411.9,446.7,439,414.3,441.9,444.2,0.9978468163641955,-3.1097364730830676E-3,0.9509924307081228,0.021822939755305908,0.9758639635916708,0.01061071919722184,7609]
["High","Q96G97-4","Isoform 3 of Seipin [OS=Homo sapiens]",15,6,13,6,462,51.1,5.27,25.3,"","","","BSCL2","","","","",1060.9,1011.5,1025.2,1091.8,1123.7,1127.9,0.9264820242866545,-0.11016510970236636,0.011689609943760068,1.9321999800356655,0.07136237251046021,1.146530719855684,1279]
["High","Q96GM5","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [OS=Homo sapiens]",57,22,71,21,515,58.2,9.25,144.54,"cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SMARCD1","ENSG00000066117","Tumor suppressor activity of SMARCB1; Thermogenesis","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Thermogenesis; Hepatocellular carcinoma",2084.7,2035.8,2102,2191.5,2277.6,2230.2,{"$f":"AVERAGE(T5506:V5506)/AVERAGE(W5506:Y5506)","v":0.928828385055155},{"$f":"LOG(Z5506,2)","v":-0.10651603315700006},{"$f":"TTEST(T5506:V5506,W5506:Y5506,2,2)","v":0.007522175599247992},{"$f":"-LOG10(AB5506)","v":2.1236565325336296},{"$f":"AB5506*7808/AF5506","v":0.055252255013102845},{"$f":"-LOG10(AD5506)","v":1.2576499923982907},1063]
["High","Q96GQ5-1","RUS1 family protein C16orf58 [OS=Homo sapiens]",5,2,5,2,468,51,6.93,16.07,"","other membranes","","C16orf58; RUSF1","ENSG00000140688","","","",172.5,178.6,152.9,164.1,151.3,149,1.0852713178294575,0.11805576152171254,0.21904696736800472,0.6594627551060215,0.4130207006059842,0.3840281809497642,4141]
["Medium","Q96GX2","Ataxin-7-like protein 3B [OS=Homo sapiens]",10,1,1,1,97,10.8,4.36,2.57,"other biological processes","other cell component","","ATXN7L3B","ENSG00000253719","","","",104.7,115,108.8,126.8,125.6,107.1,0.913769123783032,-0.13009840011696822,0.21627964644120976,0.6649843490499784,0.410678861724943,0.3864976503785624,4112]
["High","Q96H22","Centromere protein N [OS=Homo sapiens]",9,2,3,2,339,39.5,9.13,6.1,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","","CENPN","ENSG00000166451","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere","",110.2,122.4,83.3,97.5,97.4,87.5,1.1186260623229465,0.16172784847569316,0.4053588776889989,0.3921603111402921,0.6032098564886037,0.21953157067999565,5247]
["High","Q96HB5-1","Coiled-coil domain-containing protein 120 [OS=Homo sapiens]",1,1,1,1,630,67.5,9.38,2.12,"cell organization and biogenesis;other biological processes","cytoskeleton;other cytoplasmic organelle;other cell component","","CCDC120","ENSG00000147144","","","",22.3,30.5,25.1,26.2,23.8,29,0.9860759493670888,-0.02022932500279587,0.9034043844377858,0.04411780603440321,0.9498763040250784,0.02233294626590787,7426]
["High","Q96HP0","Dedicator of cytokinesis protein 6 [OS=Homo sapiens]",14,23,38,20,2047,229.4,6.74,59.64,"signal transduction","cytosol;other cell component","enzyme regulator activity","DOCK6","ENSG00000130158","","CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production","",833.6,853.4,810,783.6,768.7,798.6,1.0621464120124209,0.08698264874581382,0.03295611464942857,1.4820639949657124,0.1293072076295167,0.8883772667167837,1990]
["High","Q96I27","Zinc finger protein 625 [OS=Homo sapiens]",21,2,3,1,306,34.7,8.98,9.54,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF625","ENSG00000257591","","Generic Transcription Pathway","",35.9,30,36.3,28.9,25.3,26.8,1.2617283950617286,0.3354013831656345,0.036654627152605576,1.4358711937377486,0.13954135973064083,0.8552970494474794,2051]
["High","Q96II8-1","Leucine-rich repeat and calponin homology domain-containing protein 3 [OS=Homo sapiens]",19,11,15,11,777,86,6.71,30.21,"cell organization and biogenesis","cytosol;other cell component","","LRCH3","ENSG00000186001","","","",511.8,457.4,491.9,566.5,479.8,549.4,0.9156483048192016,-0.12713452093558905,0.2202802595417666,0.6570244204897806,0.41464519443156067,0.38232336354814855,4148]
["High","Q96IY1","Kinetochore-associated protein NSL1 homolog [OS=Homo sapiens]",22,5,8,5,281,32.1,6.79,9.22,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","","NSL1","ENSG00000117697","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",293.9,269.9,265.4,263.6,235.8,254.9,1.09929736179239,0.13658169052287109,0.10739040053888067,0.9690345378107437,0.2671246407797325,0.5732860488521506,3139]
["High","Q96JA1","Leucine-rich repeats and immunoglobulin-like domains protein 1 [OS=Homo sapiens]",2,2,2,2,1093,119,7.09,2.24,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","","LRIG1","ENSG00000144749","","Signaling by EGFR; Negative regulation of MET activity","",68.2,90.3,76.8,90.1,77.5,87.6,0.9220219435736678,-0.11712700854057165,0.42623633984718623,0.3703495261790393,0.6225314892493136,0.2058386759409223,5346]
["High","Q96JC9","ELL-associated factor 1 [OS=Homo sapiens]",18,3,4,3,268,29,5.4,9.02,"other biological processes","non-structural extracellular;nucleus;other cell component","other molecular function","EAF1","ENSG00000144597","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",87.1,93.5,95.3,87,66.3,84.5,1.1602186711522287,0.21439674160761701,0.14304073905884446,0.8445402546419162,0.3196514283261183,0.495323350630193,3494]
["High","Q96JJ7-1","Protein disulfide-isomerase TMX3 [OS=Homo sapiens]",24,9,19,9,454,51.8,4.91,47.36,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TMX3","ENSG00000166479; ENSGGOG00000005485","","Platelet degranulation","",627.7,631.5,601.7,617.6,656.6,617.3,0.9838223632038066,-0.023530245643828048,0.5599237741383564,0.25187109214441633,0.7324317018717182,0.13523286637745527,5969]
["High","Q96JM7","Lethal(3)malignant brain tumor-like protein 3 [OS=Homo sapiens]",11,7,9,6,780,88.3,6.46,13.67,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","other molecular function","L3MBTL3","ENSG00000198945","","","",304.4,302.6,313.6,390.7,390.6,411,0.7721211104587772,-0.37310093683137985,2.8270779141215878E-4,3.548662222212008,0.013542223529730894,1.8683100219573305,163]
["High","Q96JP5-1","E3 ubiquitin-protein ligase ZFP91 [OS=Homo sapiens]",13,5,6,5,570,63.4,7.36,12.7,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","other molecular function","ZFP91","ENSG00000186660","","","",218.3,215.5,234.1,217.4,242.3,225.8,0.9743253099927061,-0.03752455178388967,0.5635298739477546,0.24908305610986406,0.7345644834364052,0.13397007384054005,5990]
["High","Q96K31-1","Uncharacterized protein C8orf76 [OS=Homo sapiens]",4,2,2,2,380,43.2,5.43,4.94,"","","","C8orf76","ENSG00000189376","","","",163.4,159.7,138.1,137.8,158.5,147.4,1.0394410637818345,0.055807959831547925,0.5873818904595446,0.2310794473173539,0.7503726768174287,0.12472298822635199,6112]
["High","Q96KM6","zinc finger protein 512B [OS=Homo sapiens]",7,5,7,5,892,97.2,9.83,9.47,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512B","ENSG00000196700","","RHOV GTPase cycle","",181.1,168.5,183.8,183.5,179.3,185.1,0.973535316663625,-0.038694778755053005,0.39033961758244456,0.40855736769321976,0.5897391126323002,0.22934006802161203,5168]
["High","Q96KR1","Zinc finger RNA-binding protein [OS=Homo sapiens]",34,26,83,26,1074,116.9,9.04,188.67,"","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZFR","ENSG00000056097","Exercise-induced circadian regulation","","",2980,2925.5,3115.1,3220.7,3190.7,3241.6,0.9344866880762458,-0.09775398220978489,0.022392828957064577,1.6498910371564353,0.10297008745392239,0.9872889184057339,1698]
["High","Q96L73-1","Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [OS=Homo sapiens]",4,8,9,8,2696,296.5,8.03,12.95,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD1","ENSG00000165671","Histone modifications; Pathways affected in adenoid cystic carcinoma","PKMTs methylate histone lysines","Lysine degradation; Metabolic pathways",290.2,307.3,307.6,401.4,397.5,405.9,0.7512450199203188,-0.4126445728040697,8.9106265082352536E-5,4.050091759542935,0.008484655094670838,2.0713658072680166,82]
["High","Q96LR4","Protein FAM19A4 [OS=Homo sapiens]",8,1,1,1,140,15.7,8.9,4.32,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","TAFA4","ENSG00000163377","","","",82.2,72.9,65.6,70.6,71.9,70.8,1.0346929207688702,0.049202663939042636,0.6358167990923449,0.19666800165445766,0.7875091318707217,0.10374440147732111,6304]
["High","Q96LR5","Ubiquitin-conjugating enzyme E2 E2 [OS=Homo sapiens]",34,6,26,3,201,22.2,7.71,57.57,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","UBE2E2","ENSG00000182247","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",875.6,873.3,876,968.6,1052.3,1051.1,0.8544596354166667,-0.22691575413827045,0.005778797146688183,2.238162550319946,0.0475456776831837,1.3228889580886032,949]
["High","Q96ME7","Zinc finger protein 512 [OS=Homo sapiens]",20,13,35,13,567,64.6,9.76,77.31,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512","ENSG00000243943","","","",864.6,830.3,861.8,1019.9,1016.9,1040.7,0.8307717303005686,-0.2674759702419738,1.9894105126776535E-4,3.7012755914381086,0.011592027823124715,1.9358405851442808,134]
["High","Q96MR9","Zinc finger protein 560 [OS=Homo sapiens]",2,2,4,1,790,91.1,8.69,5.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF560","ENSG00000198028","","Generic Transcription Pathway","Herpes simplex virus 1 infection",77,75,78.4,68.8,67.4,59.9,1.1749107598164203,0.2325511812501636,0.017586461534138582,1.7548215335264137,0.08939784613187113,1.0486729445632714,1536]
["High","Q96MW5","Conserved oligomeric Golgi complex subunit 8 [OS=Homo sapiens]",11,6,10,6,612,68.4,5.2,24.18,"transport","other membranes;ER/Golgi","","COG8","ENSG00000213380","","COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",686.8,753.5,702.4,832,825.4,839.6,0.8581097316780134,-0.2207659492309793,4.5495668715648495E-3,2.342029947132573,0.041644804376527955,1.3804391736414607,853]
["High","Q96N21-1","AP-4 complex accessory subunit tepsin [OS=Homo sapiens]",4,1,3,1,525,55.1,7.03,2.75,"","other membranes;cytosol;ER/Golgi;nucleus;other cell component","","TEPSIN","ENSG00000167302","","","",19.7,28.1,28.7,35.5,37.2,30.9,0.7384169884169884,-0.4374923501065397,0.05943537892528066,1.2259549641409389,0.18750361157518847,0.726990362751891,2475]
["High","Q96N67","Dedicator of cytokinesis protein 7 [OS=Homo sapiens]",22,37,86,34,2140,242.4,6.8,150.9,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other cell component","enzyme regulator activity;other molecular function","DOCK7","ENSG00000116641","","CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production; MET activates RAP1 and RAC1","",2714.8,2721.7,2683.2,2905.6,2914.1,2922.7,0.9287724194729137,-0.10660296385576763,8.5629982666274174E-5,4.067374143890658,8.683102657899594E-3,2.0613250644045045,77]
["High","Q96NT0","Coiled-coil domain-containing protein 115 [OS=Homo sapiens]",7,1,1,1,180,19.7,6.95,3.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","CCDC115","ENSG00000136710","","RHOA GTPase cycle","",43.4,38.1,40.7,41.2,36,40.1,1.041773231031543,0.059041271790221096,0.49924631536715447,0.30168513170837197,0.6850817628096207,0.16425759344480775,5690]
["High","Q96P70","Importin-9 [OS=Homo sapiens]",29,23,79,23,1041,115.9,4.81,153.34,"transport","cytosol;nucleus;other cell component","other molecular function","IPO9","ENSG00000198700","","","Nucleocytoplasmic transport",3032.4,3169,2862.9,2852.7,3128.2,3065.9,1.001934385639121,0.002788032871878666,0.9640497324745414,0.015900561551367605,0.9826762808304463,0.007589526525336158,7660]
["High","Q96PK6-1","RNA-binding protein 14 [OS=Homo sapiens]",46,28,138,28,669,69.4,9.67,261.35,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RBM14","ENSCATG00000036313; ENSG00000239306; ENSGGOG00000014455; ENSMFAG00000003827; ENSMLEG00000024601; ENSMMUG00000020363; ENSPANG00000004924; ENSPPYG00000003015; ENSRBIG00000043267; ENSRROG00000044302","Ciliary landscape","RUNX2 regulates bone development","",5135.5,5188.4,5215.9,4797.6,4783.3,4859.1,1.076163434903047,0.10589719389731203,3.7909370953251759E-4,3.421253421951782,0.015257544763040708,1.8165153472233728,194]
["High","Q96PV7-1","Protein FAM193B [OS=Homo sapiens]",8,6,7,6,902,96.5,7.9,7.56,"","nucleus;other cell component","","FAM193B","ENSG00000146067","","","",282.8,257.2,282.7,291.9,254.3,242.4,1.0432411869135176,0.061072733062493945,0.5443284215806764,0.2641389888256757,0.7198706496785097,0.14274553298202547,5904]
["High","Q96Q05","Trafficking protein particle complex subunit 9 [OS=Homo sapiens]",5,5,5,5,1148,128.4,6.62,2.54,"developmental processes;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC9","ENSG00000167632","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",119.3,153.5,128,128.1,128.5,113.9,1.0817813765182185,0.11340896600201204,0.42306192673617465,0.3735960570426012,0.6194013733275927,0.20802783606684236,5333]
["High","Q96QC0","Serine/threonine-protein phosphatase 1 regulatory subunit 10 [OS=Homo sapiens]",27,22,38,22,940,99,9.17,64.22,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","PPP1R10","ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104","","","",2382.1,2166.6,2423.4,2230.5,1991,2143.6,{"$f":"AVERAGE(T5698:V5698)/AVERAGE(W5698:Y5698)","v":1.0953637806161725},{"$f":"LOG(Z5698,2)","v":0.13141008200151616},{"$f":"TTEST(T5698:V5698,W5698:Y5698,2,2)","v":0.12895334742159706},{"$f":"-LOG10(AB5698)","v":0.8895673797931293},{"$f":"AB5698*7808/AF5698","v":0.2991288581900861},{"$f":"-LOG10(AD5698)","v":0.5241416867742988},3366]
["High","Q96QU8","Exportin-6 [OS=Homo sapiens]",6,6,11,6,1125,128.8,6.35,18.38,"transport","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","XPO6","ENSG00000169180","","","Nucleocytoplasmic transport",407.4,425.7,402.1,416.2,380.9,703.9,0.8229180546302465,-0.2811793192399704,0.4363013526122857,0.36021344062046556,0.632264469412904,0.1991012230127781,5388]
["High","Q96RL1","BRCA1-A complex subunit RAP80 [OS=Homo sapiens]",13,8,8,8,719,79.7,5.45,16.69,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","UIMC1","ENSG00000087206","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","Homologous recombination",451.8,477.5,504.4,590,531.6,583.3,0.8409290867499559,-0.24994394780486368,0.01938719520409895,1.7124850168878663,0.09431477891190318,1.0254202489701216,1605]
["High","Q96RQ1","Endoplasmic reticulum-Golgi intermediate compartment protein 2 [OS=Homo sapiens]",13,4,9,4,377,42.5,6.77,16.2,"transport","other membranes;ER/Golgi;nucleus;other cell component","","ERGIC2","ENSG00000087502","","","",392.1,443,380.9,408.2,435.1,410.7,0.9696969696969696,-0.04439411935845356,0.5780011421010517,0.2380713034346708,0.7431307290507182,0.12893477989859886,6073]
["High","Q96RS6","NudC domain-containing protein 1 [OS=Homo sapiens]",29,12,33,12,583,66.7,5.11,51.84,"other biological processes","cytosol;nucleus","","NUDCD1","ENSG00000120526","","","",924.4,1013.1,887,813.7,963.3,862.5,1.070089032013639,0.09773083466475607,0.3459708605346976,0.46096047820696623,0.5481616231848455,0.2610913727046999,4928]
["High","Q96RW7-1","Hemicentin-1 [OS=Homo sapiens]",1,3,3,3,5635,613,6.49,4.34,"cell adhesion;cell cycle OR cell proliferation;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","HMCN1","ENSG00000143341","","","",65.7,87,71.8,86,75.9,89.4,0.8933545563072025,-0.16269522625214625,0.30054129703678606,0.522095843651526,0.5017375341593384,0.2995234089013946,4677]
["High","Q96S55-1","ATPase WRNIP1 [OS=Homo sapiens]",12,7,15,7,665,72.1,6.1,31.84,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","WRNIP1","ENSG00000124535; ENSPTRG00000017666","","","",478.5,482.1,490.5,514.3,494.3,502.7,0.9601667438628995,-0.05864312691309059,0.041952117246778074,1.3772461162324396,0.15095029099670193,0.8211660454223337,2170]
["High","Q96S99","Pleckstrin homology domain-containing family F member 1 [OS=Homo sapiens]",7,2,2,2,279,31.2,8.24,1.73,"cell organization and biogenesis;other biological processes","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PLEKHF1","ENSG00000166289","","","",60.6,76.6,71.7,84.5,80.6,83.3,0.8409822866344605,-0.24985268115337322,0.053936674666790446,1.268115832417443,0.17650358583331927,0.7532464670931308,2386]
["High","Q96SB8","structural maintenance of chromosomes protein 6 [OS=Homo sapiens]",26,27,50,27,1091,126.2,6.99,113.81,"cell organization and biogenesis;DNA metabolism;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC6","ENSG00000163029","","SUMOylation of DNA damage response and repair proteins","",2575.7,2668.3,2560.8,2683.5,2764.6,2607.1,0.9689144900188696,-0.04555874634632971,0.2140252336114278,0.6695350202388796,0.40818491061016815,0.389143053906731,4094]
["High","Q96SQ9","Cytochrome P450 2S1 [OS=Homo sapiens]",24,13,55,13,504,55.8,8.62,158.41,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","CYP2S1","ENSG00000167600","Vitamin D receptor pathway; Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II","CYP2E1 reactions; Miscellaneous substrates","Retinol metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways",2164.2,2190.1,2165.7,2306.2,2330.7,2372.7,0.930152933120292,-0.10446015531714863,1.5195102646251423E-3,2.8182963618196415,0.026018281022353314,1.584721399825441,456]
["High","Q96ST8","Centrosomal protein of 89 kDa [OS=Homo sapiens]",3,3,3,3,783,89.5,6.8,5.59,"cell-cell signaling;cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","","CEP89","ENSG00000121289","","Anchoring of the basal body to the plasma membrane","",215.1,193.3,193.9,197.5,157.1,173.5,1.1405036924824843,0.18967111751155416,0.14640132945208684,0.8344549794860714,0.3241921668638384,0.48919748279073916,3526]
["High","Q96T21","selenocysteine insertion sequence-binding protein 2 [OS=Homo sapiens]",13,7,9,7,854,95.4,8.12,24.57,"protein metabolism;other metabolic processes;developmental processes;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","SECISBP2","ENSG00000187742","","Selenocysteine synthesis","",388.9,363.1,401.9,487.6,408.9,432,0.8685735792246897,-0.20328002616330376,0.0886894154458006,1.0521282075388765,0.23788627818646893,0.6236306083190518,2911]
["High","Q96T51","RUN and FYVE domain-containing protein 1 [OS=Homo sapiens]",25,16,34,14,708,79.8,5.74,68.63,"transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RUFY1","ENSG00000176783; ENSG00000284260","","Synthesis of PIPs at the plasma membrane","Endocytosis",1711.4,1634.8,1630.7,1614.5,1533.5,1519.5,1.0662881628280663,0.09259737703010737,0.05963300363595625,1.2245133152615246,0.18797516850607446,0.725899517188726,2477]
["High","Q96TC7","Regulator of microtubule dynamics protein 3 [OS=Homo sapiens]",20,10,27,10,470,52.1,5.1,37.86,"other biological processes","non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component","cytoskeletal activity","RMDN3","ENSG00000137824","","","",1081.2,1200.3,1167.9,1138.7,1091.4,1129.3,1.0267904983032683,0.03814185070051087,0.4780876133663528,0.3204925081685256,0.666948023077449,0.17590801041662008,5597]
["High","Q99460","26S proteasome non-ATPase regulatory subunit 1 [OS=Homo sapiens]",51,38,225,38,953,105.8,5.39,535.16,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","PSMD1","ENSG00000173692","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Neutrophil degranulation","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",9353.7,9541.2,9157.9,9072.2,9569.7,9314.8,1.0034374586413992,0.004950700487601228,0.8683499351310581,0.06130522382091317,0.9299240561655879,0.03155251739762213,7291]
["High","Q99487","Platelet-activating factor acetylhydrolase 2, cytoplasmic [OS=Homo sapiens]",12,3,4,3,392,44,6.89,9.99,"other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PAFAH2","ENSG00000158006","","Platelet homeostasis","Ether lipid metabolism; Metabolic pathways",65.2,62,62.6,74.9,65.2,67.7,0.9133782483156883,-0.13071566188310224,0.12225078329871587,0.9127483495358746,0.2895159587492792,0.5383274920203922,3297]
["High","Q99538","Legumain [OS=Homo sapiens]",17,5,17,5,433,49.4,6.55,39.85,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","LGMN","ENSG00000100600","","MHC class II antigen presentation; Trafficking and processing of endosomal TLR; Vitamin D (calciferol) metabolism","Lysosome; Antigen processing and presentation",591.6,598.1,582.7,502,488.4,525.9,1.1688979753346964,0.2251490129302262,1.9584836914926626E-3,2.7080800405185834,0.028852529553159832,1.539816105460737,530]
["High","Q99570","Phosphoinositide 3-kinase regulatory subunit 4 [OS=Homo sapiens]",15,14,32,14,1358,153,7.17,45.52,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIK3R4","ENSG00000196455","Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Ciliopathies; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; DNA damage response (only ATM dependent)","PI3K Cascade; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade","Autophagy; Autophagy; Apelin signaling pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis",908.3,962.7,889.1,805,914.7,861.7,1.069226001394592,0.09656682651978078,0.197549815609445,0.7043233713474447,0.388923086303214,0.41013627655809315,3966]
["High","Q99611","Selenide, water dikinase 2 [OS=Homo sapiens]",9,2,5,2,448,47.3,5.88,5.26,"other metabolic processes","cytosol;other cell component","kinase activity;other molecular function","SEPHS2","ENSG00000179918","Selenium micronutrient network","Selenocysteine synthesis","Selenocompound metabolism; Metabolic pathways",21,20.8,22.3,23.6,12.9,21.7,1.101374570446735,0.1393052037104567,0.586476592500853,0.23174931679752275,0.7497068163468664,0.12510854052327097,6108]
["High","Q99614","tetratricopeptide repeat protein 1 [OS=Homo sapiens]",48,11,22,11,292,33.5,4.84,48.22,"other biological processes","cytosol","other molecular function","TTC1","ENSG00000113312","","","",1413.9,1246,1173.8,1591.2,1078.1,998.6,1.0452029771804028,0.06378313918244059,0.7948496599399809,0.09971500723387845,0.8867246956438594,0.05221119608865807,6999]
["High","Q99666","RANBP2-like and GRIP domain-containing protein 5/6 [OS=Homo sapiens]",22,37,115,1,1765,198.8,6.42,239.39,"transport;other biological processes","nucleus;other cell component","","RGPD5; RGPD6","ENSG00000015568; ENSG00000183054","","","",144.9,149.8,135.3,201.9,210.3,204.7,0.6970335548711298,-0.5206999864537014,2.244512672369418E-4,3.648877938257617,0.011841320909365145,1.926599848993939,148]
["High","Q99707","methionine synthase [OS=Homo sapiens]",7,7,10,7,1265,140.4,5.58,16.9,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol","other molecular function","MTR","ENSG00000116984","Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Vitamin B12 disorders; Male infertility","RHOH GTPase cycle; Cobalamin (Cbl, vitamin B12) transport and metabolism; Methylation; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG","Cysteine and methionine metabolism; Selenocompound metabolism; One carbon pool by folate; Metabolic pathways; Biosynthesis of amino acids",230.8,227.4,223.8,244.8,222.1,236.3,0.9698521046643914,-0.04416333123186914,0.36508308326263156,0.4376082903477322,0.5664882182262773,0.2468091181263093,5032]
["High","Q99732","Lipopolysaccharide-induced tumor necrosis factor-alpha factor [OS=Homo sapiens]",4,1,2,1,161,17.1,6.44,4.15,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","LITAF","ENSG00000189067","Intracellular trafficking proteins involved in CMT neuropathy","","Lysosome",225.2,216.4,207.3,237.1,248.2,243.2,0.8907343857240907,-0.1669328062687399,0.012045221380674404,1.9191852136380942,0.07217888606316634,1.1415898246920435,1303]
["High","Q99807-1","5-demethoxyubiquinone hydroxylase, mitochondrial [OS=Homo sapiens]",13,2,2,2,217,24.3,8.59,3.09,"other metabolic processes;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","COQ7","ENSG00000167186","","Ubiquinol biosynthesis","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",46,37.3,39.6,44.5,49.4,51.6,0.8446735395189003,-0.24353423742298458,0.08733029540329573,1.058835070795331,0.2354540561149631,0.6280938236618047,2896]
["High","Q99816","tumor susceptibility gene 101 protein [OS=Homo sapiens]",22,10,28,10,390,43.9,6.46,63.9,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TSG101","ENSG00000074319","Ebola virus infection in host; 7q11.23 copy number variation syndrome","HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy","Endocytosis",1463.3,1483.2,1558,1607.9,1565.3,1549.7,0.953757225433526,-0.0683060133909088,0.0966458286729539,1.0148168857990354,0.25111834618250384,0.6001215574791583,3005]
["High","Q99933","BAG family molecular chaperone regulator 1 [OS=Homo sapiens]",26,7,13,7,345,38.8,7.81,33.93,"signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","other molecular function","BAG1","ENSG00000107262","Androgen receptor signaling pathway","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",456.4,510.2,531.7,486.5,506.4,456.2,1.0339521082050929,0.04816936277551885,0.57269160664817,0.24207918184755114,0.7409405243925288,0.13021665162228377,6035]
["High","Q9BPU6","Dihydropyrimidinase-related protein 5 [OS=Homo sapiens]",35,14,40,14,564,61.4,7.2,122.07,"cell organization and biogenesis;developmental processes;signal transduction","cytosol;other cell component","cytoskeletal activity;other molecular function","DPYSL5","ENSG00000157851","","CRMPs in Sema3A signaling","Axon guidance",1636.8,1672.6,1583.5,1667.9,1640,1677.6,0.981426135793802,-0.02704840338947535,0.3356911044434852,0.47406016706981446,0.5371057671095764,0.26994018441388967,4880]
["High","Q9BPX5","actin-related protein 2/3 complex subunit 5-like protein [OS=Homo sapiens]",50,6,10,6,153,16.9,6.6,27.79,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity","ARPC5L","ENSG00000136950","Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling pathway","","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",193.6,223.3,160.2,204.1,149.2,162,1.1199301377838153,0.16340873851819215,0.45018927159237,0.3466048588329452,0.6433158551598142,0.19157574484778597,5464]
["High","Q9BQ69","O-acetyl-ADP-ribose deacetylase MACROD1 [OS=Homo sapiens]",9,3,4,3,325,35.5,9.51,2.4,"protein metabolism;other metabolic processes;stress response","nucleus","other molecular function","MACROD1","ENSG00000133315","","","",124.5,149.6,141,132.5,135.3,125,1.0567718940936863,0.07966400228891467,0.4043561024286255,0.3932359982536748,0.6021767018429731,0.22027605130876268,5243]
["High","Q9BQB6-1","vitamin K epoxide reductase complex subunit 1 [OS=Homo sapiens]",12,2,4,2,163,18.2,9.36,8.05,"protein metabolism;other metabolic processes;stress response;developmental processes","other membranes;ER/Golgi","other molecular function","VKORC1","ENSG00000167397; ENSPPAG00000037377; ENSPPYG00000007306; ENSPTRG00000008031","","Metabolism of vitamin K","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",364,388.9,383.3,341.8,346.4,369.5,1.0742176420535123,0.10328632041925732,0.08366602456519992,1.077450866252894,0.22953770899686612,0.6391459573425241,2846]
["High","Q9BQE5","apolipoprotein L2 [OS=Homo sapiens]",18,6,7,6,337,37.1,6.74,19.08,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","APOL2","ENSG00000128335","","","",504.7,511.2,472.2,578.6,581.7,625.4,0.8333426667413337,-0.2630182476105563,0.006835482433975947,2.165230828423185,0.0524277473914383,1.2804388017652895,1018]
["High","Q9BQP7","mitochondrial genome maintenance exonuclease 1 [OS=Homo sapiens]",24,7,16,7,344,39.4,7.68,32.53,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","mitochondrion","other molecular function","MGME1","ENSG00000125871","","","",869.8,908.7,919.1,1015.8,1006.9,1030.5,0.8835320319664615,-0.17864565504940402,1.9916330438679917E-3,2.7007906768078658,0.02895841863411784,1.5382251578487858,537]
["High","Q9BQS8","fyve and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",4,5,5,5,1478,166.9,4.92,8.18,"transport;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FYCO1","ENSG00000163820","","","Salmonella infection",121.3,106.5,127,149.1,130.8,127,0.8719587122143033,-0.1976682707726465,0.13077868915350385,0.8834630200567002,0.30139315375164055,0.5208666170567341,3388]
["High","Q9BRG1","Vacuolar protein-sorting-associated protein 25 [OS=Homo sapiens]",30,3,5,3,176,20.7,6.34,5.87,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS25","ENSG00000131475","","HCMV Late Events; Endosomal Sorting Complex Required For Transport (ESCRT)","Endocytosis",108.1,87,100.1,107.6,116.6,113.4,0.8744075829383885,-0.19362218264678932,0.1022034460954093,0.9905344604147251,0.25900827884224464,0.5866863540730304,3081]
["High","Q9BRP8","Partner of Y14 and mago [OS=Homo sapiens]",27,4,5,4,204,22.6,9.45,10.55,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity","PYM1","ENSG00000170473","","","Nucleocytoplasmic transport; mRNA surveillance pathway",95.3,96.8,93,108.5,88.7,74.9,1.047776552737964,0.06733108268827422,0.6816164344348346,0.16645994685298113,0.8170189008392982,0.08776789642320003,6514]
["High","Q9BRS8","La-related protein 6 [OS=Homo sapiens]",15,5,7,5,491,54.7,8.25,9.61,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity","LARP6","ENSG00000166173","","","",168.6,209.2,205,197.6,172,175.9,1.0683776351970669,0.09542168085354295,0.45797068672814667,0.33916231893854665,0.6494433566969432,0.18745872133722266,5506]
["High","Q9BRT9","DNA replication complex GINS protein SLD5 [OS=Homo sapiens]",34,6,14,6,223,26,4.98,27.89,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes","nucleus;other cell component","","GINS4","ENSG00000147536","","Unwinding of DNA","",667.6,719.5,600,643.9,573.8,574.3,1.108872767857143,0.14909384006065005,0.1938883998056475,0.7124481736500216,0.3853093982393728,0.4141903978031922,3929]
["High","Q9BS26","Endoplasmic reticulum resident protein 44 [OS=Homo sapiens]",47,18,54,18,406,46.9,5.26,119.58,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","ERP44","ENSG00000023318","","Neutrophil degranulation","",2281.5,2290.7,2323.7,2296.8,2288.6,2267,1.0063481407973849,0.009129484183832269,0.4050473439427744,0.3924942113250762,0.6028611630776178,0.2197826929207755,5246]
["High","Q9BSD7","Cancer-related nucleoside-triphosphatase [OS=Homo sapiens]",72,11,29,11,190,20.7,9.54,77.55,"","","other molecular function","NTPCR","ENSG00000135778","","","Purine metabolism; Thiamine metabolism; Metabolic pathways",1350.7,1427.9,1351.7,1405.6,1486.1,1396.2,0.9632454115067982,-0.05402468637435568,0.2421879663459095,0.6158474395554893,0.43997292722867876,0.3565740460522783,4298]
["High","Q9BSJ2-1","Gamma-tubulin complex component 2 [OS=Homo sapiens]",12,10,14,10,902,102.5,6.84,32.13,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","TUBGCP2","ENSG00000130640","15q11.2 copy number variation syndrome","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","",498.6,564.9,502,542.8,557.7,571.1,0.9365278774826515,-0.09460615529637655,0.19978174530745912,0.6994441971632276,0.3909513452031681,0.4078772881913404,3990]
["High","Q9BSQ5-1","Cerebral cavernous malformations 2 protein [OS=Homo sapiens]",16,5,5,5,444,48.8,5.54,5.73,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","mitochondrion;other cell component","","CCM2","ENSG00000136280","","","",237.2,238,218.1,193.3,210.8,221.1,1.1089251439539347,0.1491619821891227,0.09444566938837531,1.024817950964492,0.2473773185456003,0.6066401223384872,2981]
["High","Q9BSY9","Desumoylating isopeptidase 2 [OS=Homo sapiens]",35,3,17,3,194,21.4,4.92,29.12,"protein metabolism;other metabolic processes","other cell component","other molecular function","DESI2","ENSG00000121644","","","",663.1,707.5,631.1,596.3,566.1,578.6,1.149741527857553,0.20130956691730134,0.0218090699262404,1.6613628550317714,0.1009396668548222,0.9959381329622611,1687]
["High","Q9BT67","NEDD4 family-interacting protein 1 [OS=Homo sapiens]",13,2,3,2,221,24.9,4.68,7.2,"protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","NDFIP1","ENSG00000131507","","","",89.3,95.3,103.3,117,128.2,136.6,0.7540597171293871,-0.40724931384050306,0.01093676738369095,1.9611110248840742,0.06920119913440757,1.1598863799226617,1234]
["High","Q9BTC0","Death-inducer obliterator 1 [OS=Homo sapiens]",27,44,105,44,2240,243.7,7.88,264.18,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytoskeleton;nucleus;other cell component","other molecular function","DIDO1","ENSG00000101191","","","",4156.9,3659.9,4188.1,4512.4,4161.4,4443.5,0.9151959625837633,-0.1278474072522998,0.140312639117342,0.852903206721561,0.3152693773318579,0.5013182109890583,3475]
["High","Q9BTE7","DCN1-like protein 5 [OS=Homo sapiens]",30,6,13,6,237,27.5,5.58,16.27,"protein metabolism;other metabolic processes;stress response;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","DCUN1D5","ENSG00000137692","","Neddylation","",472.6,453.7,469.9,563.1,429.2,465.7,0.9576131687242797,-0.06248510308779487,0.6369465080864276,0.19589703896506466,0.7884081063948679,0.10324891896329451,6308]
["High","Q9BTV4","Transmembrane protein 43 [OS=Homo sapiens]",30,13,47,13,400,44.8,8.13,116.42,"cell organization and biogenesis","other membranes;ER/Golgi;nucleus","other molecular function","TMEM43","ENSG00000170876","Envelope proteins and their potential roles in EDMD physiopathology","","",2268.8,2431.1,2406,2088.6,2123.6,2194.3,1.1091703738390697,0.1494809873336401,0.017035390519993473,1.7686479061974094,0.08762340525698883,1.0573798730982356,1518]
["High","Q9BTZ2","dehydrogenase/reductase sdr family member 4 [OS=Homo sapiens]",11,2,2,2,278,29.5,8.56,7.68,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","DHRS4","ENSG00000157326; ENSG00000284807","","Peroxisomal protein import; RA biosynthesis pathway","Retinol metabolism; Metabolic pathways; Peroxisome",117.7,122.5,122.5,119,124,123.9,0.9885527391659852,-0.01661015927826324,0.5753684970280266,0.2400539205851367,0.7420675957705372,0.12955653254705546,6054]
["High","Q9BUB7","Transmembrane protein 70, mitochondrial [OS=Homo sapiens]",10,2,2,2,260,29,8.91,5.65,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","TMEM70","ENSG00000175606","","","",86.9,115.3,82.3,94.4,117.3,105.1,0.8980429292929294,-0.15514368288566519,0.42934011538788436,0.36719853132567387,0.6253101326149229,0.2039045338923451,5361]
["High","Q9BUI4","DNA-directed RNA polymerase III subunit RPC3 [OS=Homo sapiens]",37,14,21,14,534,60.6,7.31,42.06,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3C","ENSG00000186141","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",796.1,812.7,771.3,837,860.4,806.7,0.9504812108142646,-0.07326998703826754,0.10331240362843472,0.9858475342015594,0.2604660147015881,0.5842489348997106,3097]
["High","Q9BUP0","EF-hand domain-containing protein D1 [OS=Homo sapiens]",18,4,11,2,239,26.9,5.39,17.37,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","EFHD1","ENSG00000115468","","","",174,190.8,158.5,190.7,195.4,217.7,0.8666777078502815,-0.20643249789891005,0.09841873906356917,1.006922203427542,0.25395026920302316,0.5952513224560746,3026]
["High","Q9BV23","Monoacylglycerol lipase ABHD6 [OS=Homo sapiens]",8,2,2,2,337,38.3,8.41,2.68,"other metabolic processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ABHD6","ENSG00000163686","","Arachidonate production from DAG","Retrograde endocannabinoid signaling",37.3,32.6,34.5,42.2,27.6,44.7,0.9117903930131004,-0.1332258864144219,0.5738324083433258,0.2412149277400445,0.7413109603482276,0.12999957874839688,6044]
["High","Q9BV68-2","Isoform 2 of E3 ubiquitin-protein ligase RNF126 [OS=Homo sapiens]",28,4,9,4,311,33.8,5.47,16.16,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","RNF126","ENSG00000070423; ENSPTRG00000010160","","Antigen processing: Ubiquitination & Proteasome degradation","",194.9,224,224,233.6,205.6,211.7,0.9877093255492394,-0.01784156349119161,0.8463024862101305,0.0724743832821797,0.9190444801569818,0.036663469006426884,7190]
["High","Q9BVA0","Katanin p80 WD40 repeat-containing subunit B1 [OS=Homo sapiens]",25,13,22,13,655,72.3,7.56,54.32,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KATNB1","ENSG00000140854","Genes related to primary cilium development (based on CRISPR)","","",888.3,871.6,882.3,948.5,898.3,962.5,0.9405189904958529,-0.0884710206576684,0.050221831930147835,1.2991074496747919,0.16924128774734326,0.771493678806132,2317]
["High","Q9BVG3","E3 ubiquitin-protein ligase TRIM62 [OS=Homo sapiens]",5,2,4,2,475,54.2,6.62,8.74,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","TRIM62","ENSG00000116525","","Interferon gamma signaling","",128,112.5,108.5,98.1,109.6,107.4,1.1075848936845445,0.14741728207947488,0.1774455481069513,0.750934892100207,0.3654694907990176,0.4371488718680062,3791]
["High","Q9BVJ6-1","U3 small nucleolar RNA-associated protein 14 homolog A [OS=Homo sapiens]",26,19,39,19,771,87.9,7.87,77.94,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","UTP14A","ENSG00000156697","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1614.8,1409.2,1612.2,1548.9,1342.5,1494.5,1.0570692446248204,0.08006988533437613,0.41547921701372464,0.3814506954947909,0.6134761207343348,0.21220233731373925,5288]
["High","Q9BVM4","gamma-glutamylaminecyclotransferase [OS=Homo sapiens]",8,1,2,1,153,17.3,6.87,3.18,"other metabolic processes","cytosol","other molecular function","GGACT","ENSG00000134864","","","",86.1,91.1,85.1,86.5,83.7,93.9,0.993184399848542,-9.866493902109013E-3,0.8744780078041136,0.058251108094301014,0.933031468288401,0.030103708586254312,7318]
["High","Q9BVV7","Mitochondrial import inner membrane translocase subunit TIM21 [OS=Homo sapiens]",12,3,4,3,248,28.2,9.7,0,"cell organization and biogenesis;transport","other membranes;mitochondrion","","TIMM21","ENSG00000075336","","Mitochondrial protein import","",67.3,70.8,75.5,73.2,70.2,74.6,0.9798165137614678,-0.029416487976734854,0.6167204016519261,0.20991168449359482,0.7740480463105995,0.11123208117762896,6221]
["High","Q9BW71-1","HIRA-interacting protein 3 [OS=Homo sapiens]",11,6,8,6,556,61.9,8.54,20.65,"cell organization and biogenesis","nucleus","","HIRIP3","ENSG00000149929","22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome","","",381.2,371.2,396,436.3,388.2,417.6,0.9245632396747445,-0.11315609224562927,0.11828342830002948,0.9270760964708434,0.28329969575663505,0.547753891880147,3260]
["High","Q9BWE0","Replication initiator 1 [OS=Homo sapiens]",22,8,13,8,567,63.5,9.98,42.77,"other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","REPIN1","ENSG00000214022","","","",690.1,647.2,684.1,703.8,648.8,744.6,0.9638565706656497,-0.05310961667344129,0.4584534737481499,0.3387047322288945,0.6498919250227949,0.18715885915514519,5508]
["High","Q9BWS9-1","Chitinase domain-containing protein 1 [OS=Homo sapiens]",24,7,12,7,393,44.9,8.63,16.38,"other metabolic processes;stress response;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle","other molecular function","CHID1","ENSG00000177830","","Platelet degranulation","",297.4,298.4,290.3,296.6,264.8,291.3,1.0391696962589418,0.055431265368798034,0.3347758298010053,0.4752459048095191,0.5363007138051393,0.2705916249995893,4874]
["High","Q9BX66-12","Isoform 12 of Sorbin and SH3 domain-containing protein 1 [OS=Homo sapiens]",5,5,7,5,1294,143.7,8.6,11.95,"","","","SORBS1","","","","",319.7,316,319.8,284,283.6,287.5,1.1174131680505204,0.16016272680895238,4.5064669366420413E-5,4.346163810947573,7.0372987682602115E-3,2.152594010624956,50]
["High","Q9BXA9","sal-like protein 3 [OS=Homo sapiens]",7,7,7,6,1300,135.3,6.99,16.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SALL3","ENSG00000256463; ENSG00000277015","","","",278.1,287.2,316.9,332.5,296.8,307.6,0.9416159675525669,-0.08678930964951195,0.31218701914317504,0.505585159030465,0.5129537553598297,0.28992178634496674,4752]
["High","Q9BXF6","Rab11 family-interacting protein 5 [OS=Homo sapiens]",10,5,7,5,653,70.4,9.23,14.76,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB11FIP5","ENSG00000135631","","","Endocytosis",270.7,264.7,277.8,312.1,284.7,299.2,0.9075892857142857,-0.13988851710023412,0.0346488034302954,1.4603117588182035,0.13432862819451166,0.8718314203771673,2014]
["High","Q9BXP5","serrate RNA effector molecule homolog [OS=Homo sapiens]",42,40,132,40,876,100.6,5.96,233.1,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SRRT","ENSG00000087087","","mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes","",6178.5,5327.2,6031.5,6492.4,6135.2,6577.3,0.9131627865805083,-0.13105602716627793,0.13317165797871386,0.8755881932824979,0.30448149502131705,0.516439096641414,3415]
["Medium","Q9BXT8","Ring finger protein 17 [OS=Homo sapiens]",1,1,4,1,1623,184.5,5.4,0,"other biological processes","nucleus;other cell component","other molecular function","RNF17","ENSG00000132972","","","",138.7,159.2,124.5,147.1,222.9,154.2,0.8057993132392215,-0.31150751896996437,0.2647255095664539,0.5772042070547281,0.4637596541832785,0.33370703648226896,4457]
["High","Q9BY11","Protein kinase C and casein kinase substrate in neurons protein 1 [OS=Homo sapiens]",7,3,3,1,444,50.9,5.24,7.13,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","PACSIN1","ENSG00000124507","","Clathrin-mediated endocytosis","",26.8,19,19.2,32,22.7,23.5,0.8312020460358057,-0.2667288893915353,0.3255813243119047,0.4873405146578414,0.5266498819613324,0.27847800881789797,4827]
["High","Q9BY77","Polymerase delta-interacting protein 3 [OS=Homo sapiens]",38,14,32,1,421,46.1,9.99,82.46,"other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","POLDIP3","ENSG00000100227","","mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",1093.3,1079.3,1017.6,1146,1147.9,1095.8,0.9411452340915125,-0.08751072333001665,0.0824096036246374,1.0840221747330523,0.22704805402299535,0.6438822159858585,2834]
["High","Q9BYD2","39S ribosomal protein L9, mitochondrial [OS=Homo sapiens]",24,6,14,6,267,30.2,10.08,27.86,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL9","ENSG00000143436","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",526.2,545.7,506.2,542.6,530,480.2,1.016293147861927,0.02331660483164727,0.723371820748822,0.1406384133676776,0.846408987922494,0.07241973355981347,6673]
["High","Q9BYG3","MKI67 FHA domain-interacting nucleolar phosphoprotein [OS=Homo sapiens]",41,10,39,10,293,34.2,9.88,97.72,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","NIFK","ENSG00000155438","","","",1930.5,1967.3,1909.4,1861.9,1969.3,1880.2,{"$f":"AVERAGE(T6146:V6146)/AVERAGE(W6146:Y6146)","v":1.0167734706026545},{"$f":"LOG(Z6146,2)","v":0.02399829351088001},{"$f":"TTEST(T6146:V6146,W6146:Y6146,2,2)","v":0.4394873743357507},{"$f":"-LOG10(AB6146)","v":0.3570535968929966},{"$f":"AB6146*7808/AF6146","v":0.6349958213940676},{"$f":"-LOG10(AD6146)","v":0.19722913258435418},5404]
["High","Q9BYK8-1","Helicase with zinc finger domain 2 [OS=Homo sapiens]",12,22,34,22,2649,294.5,7.49,66.93,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HELZ2","ENSG00000130589","","PPARA activates gene expression; Heme signaling; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); Transcriptional activation of mitochondrial biogenesis; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RORA activates gene expression","",779.7,816.8,810.2,626.5,632,662.8,1.2526414406911985,0.3249735130116744,5.4698507627808232E-4,3.2620245226217683,0.017152046086663722,1.7656840650588694,249]
["High","Q9BYV8","centrosomal protein of 41 kDa [OS=Homo sapiens]",14,3,6,3,373,41.3,8.32,12.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","cytosol;cytoskeleton;other cell component","","CEP41","ENSG00000106477","Joubert syndrome; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",88.9,93.2,97.9,117.1,125.3,105.8,0.8041355542791498,-0.31448937581877245,0.021696497586329272,1.6636103676121157,0.10053783569973826,0.9976704681608376,1685]
["High","Q9BZ29-4","Isoform 4 of Dedicator of cytokinesis protein 9 [OS=Homo sapiens]",1,2,2,2,2093,238.7,7.62,3.24,"","","","DOCK9","","","","",44.4,56.2,49.3,50.4,56.4,63.7,0.8791788856304984,-0.18577135596367544,0.253135706065275,0.5966465910985552,0.4513550109517396,0.34548173163204526,4379]
["High","Q9BZE2","tRNA pseudouridine(38/39) synthase [OS=Homo sapiens]",9,4,5,4,481,55.6,7.49,12.14,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PUS3","ENSG00000110060","","tRNA modification in the nucleus and cytosol","",273.6,289.6,252.2,286,286,257,0.9835946924004826,-0.023864144894565183,0.7704702880927393,0.11324410446817337,0.8731251102217865,0.05892352171716375,6890]
["High","Q9BZH6","WD repeat-containing protein 11 [OS=Homo sapiens]",13,13,29,13,1224,136.6,6.92,55.92,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","WDR11","ENSG00000120008","","RHOH GTPase cycle","",1191.1,1413.7,995.6,977.3,1293.3,1011.6,1.0969471695813786,0.1334940453233231,0.5360353688767617,0.27080655358850547,0.7130092266081355,0.14690485017748459,5870]
["High","Q9BZK7","F-box-like/WD repeat-containing protein TBL1XR1 [OS=Homo sapiens]",27,9,24,6,514,55.6,5.55,55.77,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1XR1","ENSG00000177565","Rett syndrome causing genes","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Heme signaling; HCMV Early Events; HDACs deacetylate histones; Transcriptional activation of mitochondrial biogenesis; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity","Wnt signaling pathway",707.8,683.8,715.6,777.6,771.4,785.7,0.9025570737139677,-0.14790993035498426,1.8981951784077548E-3,2.721659134086056,0.028447424094064776,1.545957052726945,521]
["High","Q9BZV1","UBX domain-containing protein 6 [OS=Homo sapiens]",18,4,8,4,441,49.7,6.89,16.25,"protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","","UBXN6","ENSG00000167671","","","Protein processing in endoplasmic reticulum",116.3,112.9,112.1,130.9,132.6,130.3,0.8666835957338749,-0.20642269680268857,2.7782421330185418E-4,3.5562299067440786,0.013390441095437517,1.873205116628074,162]
["High","Q9C0B7","Transport and Golgi organization protein 6 homolog [OS=Homo sapiens]",13,9,13,9,1094,120.7,6.11,31.53,"transport","other membranes","","TANGO6","ENSG00000103047","","","",419,421.1,415.2,494,436.9,456.8,0.9045903293218995,-0.14466352221442844,0.05858546322594718,1.2322101318307364,0.18579825218042065,0.7309583757673984,2462]
["High","Q9C0C2","182 kDa tankyrase-1-binding protein [OS=Homo sapiens]",59,72,216,72,1729,181.7,4.86,497.34,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TNKS1BP1","ENSG00000149115","Ciliary landscape","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",8292.8,7555.2,8395.1,8873.8,7626.8,7865.2,0.9949642531745314,-7.2834010845921554E-3,0.9341132073088553,0.029600487442070843,0.965905962477492,0.015065153051460563,7551]
["High","Q9C0H2-1","Protein tweety homolog 3 [OS=Homo sapiens]",7,4,14,4,523,57.5,5.39,35.23,"transport","plasma membrane;other membranes","transporter activity","TTYH3","ENSG00000136295","","Stimuli-sensing channels","",424.4,455.4,477.2,393.7,371.3,407.6,1.157257376769572,0.21070975890974347,0.029873115241057437,1.5247194857502382,0.12302177415726608,0.9100180140936502,1896]
["High","Q9C0J8","pre-mRNA 3' end processing protein WDR33 [OS=Homo sapiens]",18,19,34,19,1336,145.8,9.17,53.9,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","WDR33","ENSG00000136709","","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",1462,985,1393.4,1813.7,1478,1626,0.7809341765459463,-0.35672714341224265,0.11349811452820689,0.945011353068189,0.2759007715554917,0.5592470850161969,3212]
["High","Q9GZP9","Derlin-2 [OS=Homo sapiens]",16,2,5,2,239,27.5,7.28,13.02,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","DERL2","ENSG00000072849","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",73.9,76.2,81,72.2,69.8,72.5,1.0773892773892775,0.10753961208072312,0.07051098242321863,1.1517432342945868,0.20712932684743832,0.6837584062426647,2658]
["High","Q9GZT4","serine racemase [OS=Homo sapiens]",9,2,4,2,340,36.5,6.54,5.29,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","SRR","ENSG00000167720","Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; D-Amino acid metabolism; Metabolic pathways",72.7,53.9,74.7,54,52.4,62.1,1.194658753709199,0.25659858085211923,0.2072353616301951,0.6835361367137844,0.40061740619177105,0.39727018522513735,4039]
["High","Q9GZU8","Protein FAM192A [OS=Homo sapiens]",27,6,10,6,254,28.9,5.45,17.06,"other biological processes","nucleus","","PSME3IP1","ENSG00000172775","","","",580.4,507.5,539.9,792,523,505.7,0.8940517383423958,-0.16156977299757294,0.5358449556139923,0.2709608533331363,0.7129988775449986,0.14691115384574596,5868]
["High","Q9GZY8-1","Mitochondrial fission factor [OS=Homo sapiens]",28,5,10,5,342,38.4,8.95,19.97,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","C2orf33; MFF","ENSG00000168958","","","",101.9,123,97.2,111.9,106.1,93.2,1.0350257069408741,0.049666600396623024,0.7261559267176341,0.1389701136773046,0.8475075449643179,0.07185642678649232,6690]
["High","Q9H019-1","Mitochondrial fission regulator 1-like [OS=Homo sapiens]",25,5,12,5,292,31.9,6.1,27.63,"cell organization and biogenesis;other metabolic processes","mitochondrion","","FAM54B; MTFR1L","ENSG00000117640; ENSPPAG00000030443","","","",304.1,301.6,316.1,317.7,261.9,252.2,1.108199086318827,0.148217082690293,0.22440379597930216,0.6489698008966215,0.4198765490070432,0.3768783809496949,4173]
["High","Q9H089","Large subunit GTPase 1 homolog [OS=Homo sapiens]",24,14,30,14,658,75.2,6.38,64.71,"transport","cytosol;ER/Golgi;nucleus","other molecular function","LSG1","ENSG00000041802","","","Ribosome biogenesis in eukaryotes",1161.2,1181.5,1216.5,1234,1249.4,1300.5,0.9406168239118369,-0.08832095835688225,0.04389709838869595,1.3575641858040137,0.15516004717923856,0.8092200970168132,2209]
["High","Q9H0A8-1","COMM domain-containing protein 4 [OS=Homo sapiens]",37,6,8,6,199,21.8,7.31,22.09,"","plasma membrane;other membranes;cytosol;nucleus;other cell component","","COMMD4","ENSG00000140365; ENSGGOG00000014844","","Neddylation","",307.7,363.8,249.6,258.3,386.3,323.5,0.9514512963536826,-0.07179828632013283,0.7675513500397179,0.11489256009455938,0.8713348271459898,0.059814926921918615,6878]
["High","Q9H0G5","Nuclear speckle splicing regulatory protein 1 [OS=Homo sapiens]",20,9,13,9,558,66.4,8.84,21.21,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","NSRP1","ENSG00000126653","","","",572,603.4,590,708.2,700.9,697.8,0.8379135222364614,-0.25512673816850073,2.9020919512025414E-4,3.5372888312962085,0.013650321659632194,1.8648571146776285,166]
["High","Q9H0Q0","Protein FAM49A [OS=Homo sapiens]",18,4,5,4,323,37.3,6.01,9.92,"cell organization and biogenesis","other membranes","other molecular function","CYRIA","ENSG00000197872","","","",120.7,141.6,104.4,91.7,88.4,84,1.3884892086330936,0.47351596454457306,0.03585088713725156,1.4455000931608644,0.1375546568882851,0.8615247020634678,2035]
["High","Q9H0R8-1","Gamma-aminobutyric acid receptor-associated protein-like 1 [OS=Homo sapiens]",13,2,4,1,117,14,8.73,6.43,"cell organization and biogenesis;other metabolic processes;stress response","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","gabarapl1; Gabarapl1; GABARAPL1; gabarapl1.L; GBRL1; LOC101346525; LOC110090845; LOC111142199; LOC113417224; LOC113444478; LOC113982994","ENSACUG00000002920; ENSAMEG00000026339; ENSANAG00000017627; ENSBIXG00000025666; ENSBIXG00005000420; ENSBMUG00000009257; ENSBTAG00000011765; ENSCAFG00000013479; ENSCANG00000037817; ENSCATG00000043779; ENSCCAG00000031173; ENSCGRG00001022681; ENSCGRG00015025519; ENSCHIG00000025179; ENSCJAG00000048408; ENSCPOG00000006718; ENSCPRG00005001116; ENSCSAG00000009078; ENSFCAG00000022695; ENSG00000139112; ENSGAGG00000013450; ENSGALG00000014723; ENSGGOG00000022360; ENSLCNG00005007852; ENSLSDG00000014620; ENSMFAG00000037621; ENSMGAG00000014228; ENSMLEG00000037692; ENSMMUG00000002197; ENSMNEG00000040661; ENSMODG00000018255; ENSMUSG00000030161; ENSNLEG00000029077; ENSNVIG00000010216; ENSOGAG00000000859; ENSPANG00000015789; ENSPCLG00000013759; ENSPPAG00000035460; ENSPSIG00000008179; ENSPTRG00000052409; ENSPTXG00000014934; ENSRBIG00000038034; ENSRFEG00010012750; ENSRNOG00000053362; ENSRROG00000036376; ENSSBOG00000023150; ENSSHBG00005010614; ENSSTOG00000002246; ENSTGUG00000029032; ENSTMTG00000017402; ENSTSYG00000033601; ENSTTRG00000009099; ENSUAMG00000018185; ENSUMAG00000016270; ENSVVUG00000005149; ENSXETG00000016242","Senescence and autophagy in cancer","Macroautophagy; Macroautophagy; Macroautophagy; Macroautophagy; Macroautophagy","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse",103.9,133.4,102.9,114.5,118,103.9,1.0112960760998813,0.016205435408241008,0.9128110375902234,0.039619117126710915,0.9538582148694411,0.02051617569011249,7472]
["High","Q9H0W5","Coiled-coil domain-containing protein 8 [OS=Homo sapiens]",16,5,6,5,538,59.3,8.63,10.27,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","CCDC8","ENSG00000169515","","Neddylation","",210.6,225.6,205.3,241.5,229.5,219.6,0.9289024037069215,-0.10640106887634188,0.13567349894491743,0.8675049746391853,0.3082160837247353,0.5111447021177753,3437]
["High","Q9H0W9","Ester hydrolase C11orf54 [OS=Homo sapiens]",23,6,12,6,315,35.1,6.7,21.13,"","nucleus","other molecular function","C11orf54","ENSG00000182919","","","",402.1,462.8,378.3,460.7,448.2,438.5,0.9226658750185542,-0.11611979557957051,0.2519711799763434,0.5986491302224868,0.4501008861256667,0.346690132053504,4371]
["High","Q9H1C4","Protein unc-93 homolog B1 [OS=Homo sapiens]",4,2,2,2,597,66.6,6.96,3.23,"stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding","UNC93B1","ENSG00000110057","","Trafficking and processing of endosomal TLR; UNC93B1 deficiency - HSE","",33.5,35,36.6,46.4,38.9,42.1,0.824960753532182,-0.27760260829412214,0.03407925053310779,1.4675099647537733,0.13258135932362014,0.8775175325826234,2007]
["High","Q9H1K0","Rabenosyn-5 [OS=Homo sapiens]",8,6,8,6,784,88.8,5.5,18.35,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RBSN","ENSG00000131381","","Factors involved in megakaryocyte development and platelet production; Toll Like Receptor 9 (TLR9) Cascade","Endocytosis",413.4,361.2,387.5,419.2,415.6,401.2,0.9402103559870549,-0.08894452364215646,0.19942476212389695,0.7002209173077749,0.3906443910344675,0.40821840701360823,3986]
["Low","Q9H211","DNA replication factor Cdt1 [OS=Homo sapiens]",1,1,1,1,546,60.4,9.77,1.75,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CDT1","ENSG00000167513","Retinoblastoma gene in cancer; DNA replication","Orc1 removal from chromatin; Activation of the pre-replicative complex; CDT1 association with the CDC6:ORC:origin complex; G1/S-Specific Transcription","",15.5,11.6,11.7,43.1,27.9,33.6,0.3709369024856596,-1.4307542940598141,0.008956579042796477,2.0478578370489933,0.06129094580732243,1.2126036768085726,1141]
["High","Q9H2D6","TRIO and F-actin-binding protein [OS=Homo sapiens]",9,16,28,16,2365,261.2,8.48,54.26,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TRIOBP","ENSG00000100106","","","",1026.3,986.1,974.1,989.8,1023.3,1009.7,0.9879912663755458,-0.01742980612637631,0.5496229793481218,0.25993511802372465,0.7246633270432514,0.13986371641836956,5922]
["High","Q9H2H8-1","peptidyl-prolyl cis-trans isomerase-like 3 [OS=Homo sapiens]",37,7,28,7,161,18.1,6.79,42.36,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","CLK1; LOC111141199; PPIL3","ENSAMEG00000005917; ENSCAFG00000011929; ENSECAG00000019985; ENSFCAG00000005373; ENSG00000240344; ENSGGOG00000022268; ENSOCUG00000010661; ENSPPAG00000039183; ENSPPYG00000013062; ENSPTRG00000012793; ENSRFEG00010017851; ENSSSCG00000016096; ENSSSCG00070023158; ENSSSUG00005004462; ENSSTOG00000028255; ENSUMAG00000021460","mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","",998.6,1002.9,1026.5,1111.6,1092.1,1148.1,0.9033951906438332,-0.14657086148913123,0.004354810489885289,2.3610307396202375,0.04067267979069897,1.3906972124006185,836]
["High","Q9H2S1-1","Small conductance calcium-activated potassium channel protein 2 [OS=Homo sapiens]",2,1,1,1,579,63.7,9.52,2.44,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;cytoskeletal activity;other molecular function","KCNN2","ENSG00000080709","Brain-derived neurotrophic factor (BDNF) signaling pathway","Ca2+ activated K+ channels; Acetylcholine inhibits contraction of outer hair cells","Serotonergic synapse; Insulin secretion; GnRH secretion; Bile secretion",15.3,26.3,19.3,19.9,16.1,22.6,1.0392491467576792,0.05554156348408457,0.8470506675467859,0.07209061094692214,0.9190899961374798,0.036641960961800495,7196]
["High","Q9H329","Band 4.1-like protein 4B [OS=Homo sapiens]",4,4,14,1,900,99.7,9.04,16,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","EPB41L4B","ENSG00000095203","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","Tight junction",152.7,157.7,157.8,250.9,225.5,226.4,0.6661923733636881,-0.5859892568963634,7.7169595823960678E-4,3.112553774363021,0.018712428701661024,1.7278698414002167,322]
["High","Q9H3C7","Gametogenetin-binding protein 2 [OS=Homo sapiens]",4,2,2,2,697,79,6.38,3.02,"developmental processes;other biological processes","nucleus;other cell component","","GGNBP2","ENSG00000275099; ENSG00000278311","","","",126.2,132.2,137,163.5,157.4,148.5,0.8423519386450787,-0.2475049707939625,0.01001476399246209,1.9993592808166467,0.06538066659961873,1.184550655810403,1196]
["High","Q9H3K6-1","bola-like protein 2 [OS=Homo sapiens]",29,2,4,2,86,10.1,6.52,6.85,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","BOLA2; BOLA2B","ENSG00000169627; ENSG00000183336","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",119,126.8,129.6,153.3,128.1,119.7,0.9359262029419098,-0.09553331598363468,0.46360311834066403,0.33385365149707746,0.6542225100314304,0.18427451705259454,5533]
["High","Q9H3P2-1","Negative elongation factor A [OS=Homo sapiens]",39,14,43,14,528,57.2,9.03,96.4,"developmental processes;other biological processes","cytosol;nucleus","other molecular function","NELFA","ENSG00000185049","Initiation of transcription and translation elongation at the HIV-1 LTR","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1467.1,1485.5,1554.3,1693.2,1513.6,1581.3,0.9412710678557256,-0.08731784384029999,0.18558366969006532,0.7314602418861132,0.37520385627654845,0.42573270667085367,3862]
["High","Q9H3Z4","DnaJ homolog subfamily C member 5 [OS=Homo sapiens]",20,4,12,4,198,22.1,5.07,29.22,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","DNAJC5","ENSG00000101152","","Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; GABA synthesis, release, reuptake and degradation","Protein processing in endoplasmic reticulum",590.3,619.2,627.8,555.3,576.7,558.6,1.0867739264166567,0.12005185834217669,0.020491241901841976,1.688431719745578,0.09720268333510458,1.0123217459631937,1646]
["High","Q9H479","fructosamine-3-kinase [OS=Homo sapiens]",15,5,7,5,309,35.1,7.55,16.94,"protein metabolism;other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","FN3K","ENSG00000167363","","Gamma carboxylation, hypusine formation and arylsulfatase activation","",259.5,263,238.1,281.6,240.7,268.6,0.9616892148185612,-0.05635735544600381,0.5205538963918604,0.28353429844201045,0.7018623420873159,0.15374805871674901,5791]
["High","Q9H4B6","Protein salvador homolog 1 [OS=Homo sapiens]",20,6,10,6,383,44.6,9.09,16.57,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SAV1","ENSG00000151748","Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma","Signaling by Hippo","Hippo signaling pathway; Hippo signaling pathway",303.9,286.2,308.3,288.7,263.1,264.1,1.1011153327613679,0.1389655872388687,0.06286198175361002,1.2016119317643383,0.19430972032153088,0.711505473325015,2526]
["High","Q9H4G0-1","Band 4.1-like protein 1 [OS=Homo sapiens]",19,13,26,12,881,98.4,5.62,53.71,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","EPB41L1","ENSG00000088367","Splicing factor NOVA regulated synaptic proteins","Trafficking of AMPA receptors; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Neurexins and neuroligins","",623.1,658.5,645.3,680.7,656.8,679.9,0.9551402795677604,-0.06621546040452997,0.08053795050384098,1.0939994263327306,0.22426544847859858,0.6492376309687161,2804]
["High","Q9H4M3-2","Isoform 2 of F-box only protein 44 [OS=Homo sapiens]",13,2,2,2,224,25.7,7.88,5.88,"","","","FBXO44","","","","",44.1,58.3,55.7,55.3,45.5,55.2,1.0134615384615386,0.019291338608760356,0.9038613125315537,0.0438982020721181,0.9502287771975725,0.022171821329080205,7427]
["High","Q9H501","ESF1 homolog [OS=Homo sapiens]",25,19,44,19,851,98.7,5.11,98.45,"RNA metabolism OR transcription;other metabolic processes","nucleus","","ESF1","ENSG00000089048","","","",2457,2136.8,2316.5,2699.4,2509.8,2605.6,0.8842580744228897,-0.17746060722446935,0.048738288647300676,1.3121297243117855,0.16567198857558715,0.7807509148481762,2297]
["High","Q9H5L6","DNA transposase THAP9 [OS=Homo sapiens]",2,2,2,2,903,103.3,9.13,3.01,"DNA metabolism;other metabolic processes","","nucleic acid binding activity;other molecular function","THAP9","ENSG00000168152","","","",54.8,66.6,63.9,43.6,42.7,54,1.320741268709907,0.4013478724073662,0.04205091679418542,1.3762245312735504,0.15102739573551047,0.8209442663651907,2174]
["High","Q9H6A9-1","Pecanex-like protein 3 [OS=Homo sapiens]",3,3,4,3,2034,221.9,6.64,8.04,"","other membranes","","PCNX3","ENSG00000197136","","","",287.4,314.4,260.8,234.1,237.6,240,1.212027539693691,0.27742248010469556,0.03194353514473411,1.4956170227969958,0.12705813673463265,0.8959975177383668,1963]
["High","Q9H6E4","Coiled-coil domain-containing protein 134 [OS=Homo sapiens]",20,4,12,4,229,26.5,8.85,30.41,"developmental processes","non-structural extracellular;ER/Golgi;nucleus","","CCDC134","ENSG00000100147","","","",442.6,444.8,462.7,411.5,453.8,418.7,1.0514797507788163,0.0724210671573997,0.20411518448514263,0.6901246861569706,0.3966479244549511,0.4015948139105656,4018]
["High","Q9H6S0","Probable ATP-dependent RNA helicase YTHDC2 [OS=Homo sapiens]",7,6,9,6,1430,160.1,8.4,14.29,"cell cycle OR cell proliferation;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","YTHDC2","ENSG00000047188","","","",264.4,270.1,265.8,291.2,313.2,289.3,0.8954906568199618,-0.15924971508240846,0.016657134242118427,1.7783997142071257,0.0863031878981159,1.0639731618631223,1507]
["High","Q9H6S3","epidermal growth factor receptor kinase substrate 8-like protein 2 [OS=Homo sapiens]",6,4,4,4,715,80.6,6.84,8.54,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","cytoskeletal activity","EPS8L2","ENSG00000177106","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",207.8,205.6,204.7,252.3,211.3,236.5,0.8828738751606912,-0.1797207415852008,0.08453885059001841,1.0729436612361924,0.2311202189799943,0.6361620596816938,2856]
["High","Q9H6Z4-2","Isoform 2 of Ran-binding protein 3 [OS=Homo sapiens]",36,14,47,14,562,59.7,4.81,105.84,"","","","RANBP3","","","","",1906.9,1921.7,1637,1847.5,1762.9,1672.9,1.0345049495580414,0.048940547745780036,0.5950519554235529,0.22544511331570477,0.7558427961521232,0.12156852177792679,6147]
["High","Q9H7H0","Methyltransferase-like protein 17, mitochondrial [OS=Homo sapiens]",5,2,2,2,456,50.7,9.33,5.01,"protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus","other molecular function","METTL17","ENSG00000165792","","","",51.9,53.7,56.8,64.9,67.5,66.1,0.8181360201511333,-0.2895873748451443,0.001738286728893935,2.7598785854789827,0.027254101966272776,1.564568123580065,498]
["High","Q9H7L9","Sin3 histone deacetylase corepressor complex component SDS3 [OS=Homo sapiens]",16,5,8,5,328,38.1,5.66,18.91,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","SUDS3","ENSG00000111707","","Ub-specific processing proteases; NoRC negatively regulates rRNA expression; HDACs deacetylate histones; Potential therapeutics for SARS","",222.6,181.1,189.6,268.5,218.9,202.2,0.8603538283062645,-0.2169979916291065,0.24524644057660622,0.6103972871046154,0.44326023333845865,0.353341229260892,4320]
["Medium","Q9H816","5' exonuclease Apollo [OS=Homo sapiens]",2,1,1,1,532,60,8.41,0,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DCLRE1B","ENSG00000118655","","Fanconi Anemia Pathway","",68.3,72.1,75.2,80.2,80.1,84.7,0.8799999999999999,-0.18442457113742763,0.017394802207655793,1.7595805051522087,0.0887703370178931,1.051732131311172,1530]
["High","Q9H8E8-1","Cysteine-rich protein 2-binding protein [OS=Homo sapiens]",9,6,6,6,782,88.8,6.57,14.23,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","KAT14","ENSG00000149474","","HATs acetylate histones","",249.5,249.2,249.6,241.2,283.6,247.6,0.9687985499741066,-0.045731389172555675,0.5755870267891966,0.23988900322980147,0.7419817574987696,0.12960677223446773,6057]
["High","Q9H8G2-1","Caspase activity and apoptosis inhibitor 1 [OS=Homo sapiens]",25,6,14,6,361,38.3,4.72,35.38,"other biological processes","","","CAAP1","ENSG00000120159","Acute viral myocarditis","","",351.6,335.6,335.8,362.4,370.2,383.9,0.916256157635468,-0.12617710607714486,0.019248817191111,1.7155959520337116,0.09393422789262168,1.027176130031001,1600]
["Medium","Q9H8M1","Coenzyme Q-binding protein COQ10 homolog B, mitochondrial [OS=Homo sapiens]",3,1,1,1,238,27.1,9.6,2.33,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ10B","ENSG00000115520","","Respiratory electron transport","",114.4,112.1,107.7,97.4,96.3,95.5,1.1556016597510375,0.2086441811100703,1.8262606682599846E-3,2.7384372340813785,0.027904977099361957,1.5543183295574556,511]
["High","Q9H900-1","Protein zwilch homolog [OS=Homo sapiens]",25,11,21,11,591,67.2,6.27,32.56,"cell cycle OR cell proliferation;signal transduction;other biological processes","cytosol;other cell component","","ZWILCH","ENSG00000174442","","RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",764,798.9,732.2,789.5,839.8,784.8,0.950706267346009,-0.07292842372847952,0.20309632687370566,0.6922979310161984,0.39545539157852716,0.40290249897774527,4010]
["High","Q9H920","RING finger protein 121 [OS=Homo sapiens]",5,1,1,1,327,37.9,7.06,3.13,"protein metabolism;other metabolic processes;stress response;signal transduction","other membranes;ER/Golgi","other molecular function","RNF121","ENSG00000137522","","","",22.5,19.4,15.4,15.6,19.6,23.4,0.9778156996587029,-0.03236552566534333,0.8938427841213676,0.04873886150926353,0.9440179167347001,0.02501976304814553,7393]
["High","Q9H9B1","histone-lysine N-methyltransferase EHMT1 [OS=Homo sapiens]",28,24,47,23,1298,141.4,5.76,99.5,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","EHMT1","ENSG00000181090","Histone modifications; MTHFR deficiency","Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; Senescence-Associated Secretory Phenotype (SASP); Regulation of TP53 Activity through Methylation; Transcriptional Regulation by VENTX","Lysine degradation; Metabolic pathways; Longevity regulating pathway",1483.8,1330.2,1486.9,1577.5,1467.8,1601.3,0.9256015150862995,-0.11153686894055295,0.15609838025073294,0.8066016033553812,0.3387482359637918,0.47012295770627843,3598]
["High","Q9H9C1-1","Spermatogenesis-defective protein 39 homolog [OS=Homo sapiens]",31,13,18,13,493,57,7.4,40.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","C14orf133; VIPAS39","ENSG00000151445; ENSPTRG00000006581","","","",711.9,692.3,721.9,748.3,721.8,696.6,0.981261826741127,-0.027289957686995908,0.47713176001565016,0.32136167390331777,0.6662097250003928,0.1763890319823074,5592]
["High","Q9H9J4-2","Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 42 [OS=Homo sapiens]",10,10,15,10,1316,144.2,8.47,24.71,"","","","USP42","","","","",558.6,553.4,524.3,544.3,498.7,527.3,1.0420301853149079,0.05939706991332281,0.2666311567183633,0.5740891032333121,0.4661567558569146,0.33146801731009584,4466]
["High","Q9H9Z2","Protein lin-28 homolog A [OS=Homo sapiens]",66,13,106,11,209,22.7,8.07,240.43,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","LIN28A","ENSG00000131914","Cardiac progenitor differentiation; CCL18 signaling pathway","Transcriptional regulation of pluripotent stem cells","",4208.4,4446.7,4042.3,4075.2,4508.2,4277.4,0.9872947250559839,-0.01844727575205793,0.766712776343089,0.11536729969006652,0.8707626702089948,0.06010019753373135,6875]
["Medium","Q9HAB3","Solute carrier family 52, riboflavin transporter, member 2 [OS=Homo sapiens]",2,1,1,1,445,45.7,7.15,1.63,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC52A2","ENSG00000185803; ENSG00000285112","","Vitamin B2 (riboflavin) metabolism","",51.9,47.5,45.2,47.8,38.5,40.9,1.136792452830189,0.18496888166676279,0.1642592187371535,0.7844702471299763,0.34889444502167966,0.4573059451854145,3676]
["High","Q9HAS0","Protein Njmu-R1 [OS=Homo sapiens]",26,6,7,6,396,44.6,5.03,15.59,"cell organization and biogenesis;transport","ER/Golgi;other cell component","","C17orf75","ENSG00000108666","","","",213.6,196.3,191.9,216.6,208.5,210.5,0.9468219005663939,-0.07883501801518229,0.18559557122021353,0.7314323913583808,0.37503370085078347,0.42592970444320105,3864]
["High","Q9HAV7","GrpE protein homolog 1, mitochondrial [OS=Homo sapiens]",41,10,16,10,217,24.3,8.12,27.2,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","GRPEL1","ENSG00000109519","","Mitochondrial protein import","",1102,1202,944.6,1081.8,757.8,729.9,1.264292663942401,0.33833046347179024,0.1701879192127206,0.7690712715455771,0.3558723281234394,0.44870578050000115,3734]
["High","Q9HB09-1","Bcl-2-like protein 12 [OS=Homo sapiens]",17,5,8,5,334,36.8,9.22,16.21,"other biological processes","nucleus","","BCL2L12","ENSG00000126453","Regulation of apoptosis by parathyroid hormone-related protein","","",387.4,392.3,419.9,297,290.4,283.3,1.3777420466291488,0.4623057988657157,5.4214473533263315E-4,3.265884755223522,0.017207585745842274,1.7642800576682658,246]
["High","Q9HBE1-1","POZ-, AT hook-, and zinc finger-containing protein 1 [OS=Homo sapiens]",5,3,8,2,687,74,8.35,21.19,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PATZ1; ZNF278","ENSANAG00000029603; ENSCCAG00000028772; ENSCJAG00000010978; ENSG00000100105; ENSSBOG00000003894","Androgen receptor signaling pathway","","",127.6,120.8,128.5,135.7,139.9,127.1,0.9359324559225228,-0.09552367728139766,0.12752351730603065,0.8944097172345534,0.29713626473455307,0.5270443404111895,3351]
["High","Q9HBL8","NmrA-like family domain-containing protein 1 [OS=Homo sapiens]",10,3,7,3,299,33.3,7.52,12.91,"","cytosol;nucleus;other cell component","other molecular function","NMRAL1","ENSG00000153406; ENSG00000274684","","Urea cycle","",297.4,312,311.9,316.3,321.8,302.9,0.9790648246546225,-0.03052370991886871,0.42602907239483817,0.37056076345633476,0.6225781391089082,0.2058061329806053,5343]
["High","Q9HC07","Transmembrane protein 165 [OS=Homo sapiens]",22,4,12,4,324,34.9,7.02,39.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","TMEM165","ENSG00000134851","IL-18 signaling pathway","","",359.6,378.4,429.8,402.2,407.6,429.2,0.9425343018563357,-0.08538297123548204,0.35184412913979096,0.45364969120036197,0.553982448139441,0.25650399483283653,4959]
["Low","Q9HC96","Calpain-10 [OS=Homo sapiens]",1,1,1,1,672,74.9,7.74,1.79,"cell organization and biogenesis;protein metabolism;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","CAPN10","ENSG00000142330","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",50.9,42.3,54.7,54.7,54,55.1,0.9029304029304027,-0.14731330454194125,0.22343000709266003,0.6508585006939324,0.41885750189183424,0.37793370177810337,4165]
["High","Q9HCE3","Zinc finger protein 532 [OS=Homo sapiens]",16,15,26,14,1301,141.6,8.65,48.84,"","nucleus","nucleic acid binding activity;other molecular function","ZNF532","ENSG00000074657","","","",751.6,732.7,768.7,983,960.3,959,0.7762808806808393,-0.3653493395813474,7.608415680389181E-5,4.118705768051759,0.008486644233211245,2.0712640034073804,70]
["High","Q9HCJ3","Ribonucleoprotein PTB-binding 2 [OS=Homo sapiens]",3,2,3,2,691,74.3,7.47,2.09,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RAVER2","ENSG00000162437","","","",129.2,154.4,128.9,130.8,201,199.4,0.776543674698795,-0.3648610273263846,0.1834912586896512,0.7363846202035724,0.37271065240603446,0.4286281945414448,3844]
["High","Q9HCP0-1","Casein kinase I isoform gamma-1 [OS=Homo sapiens]",11,4,5,2,422,48.5,9.01,8.29,"cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK1G1","ENSG00000169118; ENSMFAG00000002355; ENSMMUG00000021124; ENSMNEG00000044820; ENSPPYG00000006548; ENSRROG00000038647","Wnt signaling pathway; Hedgehog signaling pathway","","Hedgehog signaling pathway",36.9,31.5,32.9,29.5,36.8,32.2,{"$f":"AVERAGE(T6594:V6594)/AVERAGE(W6594:Y6594)","v":1.0284263959390865},{"$f":"LOG(Z6594,2)","v":0.04043854445739979},{"$f":"TTEST(T6594:V6594,W6594:Y6594,2,2)","v":0.744804524579803},{"$f":"-LOG10(AB6594)","v":0.12795769374251295},{"$f":"AB6594*7808/AF6594","v":0.8587468588185324},{"$f":"-LOG10(AD6594)","v":0.06613483852077517},6772]
["High","Q9HD20","manganese-transporting ATPase 13A1 [OS=Homo sapiens]",16,17,38,17,1204,132.9,8.13,79.63,"transport;other biological processes","other membranes;ER/Golgi","transporter activity;other molecular function","ATP13A1","ENSG00000105726","","Ion transport by P-type ATPases","",1469.2,1498.2,1400.7,1321.7,1324.2,1410.3,1.0768946304422862,0.10687709521619844,0.06441471550296915,1.1910149069928575,0.1964648822840559,0.7067150676460716,2560]
["High","Q9HD42-1","Charged multivesicular body protein 1a [OS=Homo sapiens]",16,5,10,5,196,21.7,8.06,18.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CHMP1A","ENSG00000131165; ENSPPAG00000031215; ENSPPYG00000007667","","HCMV Late Events","Endocytosis; Necroptosis",586.7,608.1,533.5,603.8,538.7,552.3,1.0197663441113998,0.028238629836496013,0.7264351473044145,0.1388031513935143,0.847580040369526,0.0718192790252358,6692]
["High","Q9NNW7-1","thioredoxin reductase 2, mitochondrial [OS=Homo sapiens]",19,6,8,5,524,56.5,7.5,22.01,"stress response;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","TXNRD2","ENSG00000184470","Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Oxidative stress response; 22q11.2 copy number variation syndrome","Detoxification of Reactive Oxygen Species","Selenocompound metabolism; Pathways in cancer; Hepatocellular carcinoma",216.6,235.6,228,239.6,239.7,254.4,0.9270819135886604,-0.10923127911404,0.07338471314586016,1.1343943990463148,0.21229634688509674,0.673057478944196,2699]
["High","Q9NP73-1","Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 [OS=Homo sapiens]",8,6,6,6,1137,126,6.74,8.65,"protein metabolism","other membranes;ER/Golgi","other molecular function","ALG13","ENSG00000101901","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG14 causes ALG14-CMS","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways",92.4,95.5,81.6,87,131.7,104.5,0.8338490099009901,-0.2621419251119269,0.26053475713819735,0.5841343306124279,0.4590962274283559,0.3380962759854044,4431]
["Medium","Q9NP87","DNA-directed DNA/RNA polymerase mu [OS=Homo sapiens]",2,1,1,1,494,54.8,8.41,2.27,"DNA metabolism;other metabolic processes;stress response","nucleus","nucleic acid binding activity;other molecular function","POLM","ENSG00000122678","Non-homologous end joining; DNA repair pathways, full network","Nonhomologous End-Joining (NHEJ)","Non-homologous end-joining",19.7,21.6,26.1,20.1,34.3,24,0.8596938775510203,-0.21810506293334986,0.4737253745378241,0.3244733521801806,0.6637085455573893,0.17802259057774536,5573]
["Medium","Q9NPE2-2","Neugrin [OS=Homo sapiens]",3,1,1,1,291,32.4,9.1,2.4,"developmental processes;other biological processes","non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus","nucleic acid binding activity","NGRN","ENSG00000182768","","","",32.1,40.8,30.8,35,29.9,27.4,1.123510292524377,0.16801334116745137,0.3799909973948082,0.4202266924044313,0.5808476326661437,0.23593777633717358,5108]
["High","Q9NPH2","Inositol-3-phosphate synthase 1 [OS=Homo sapiens]",24,12,52,12,558,61,5.76,130.48,"other metabolic processes","cytosol;other cell component","other molecular function","ISYNA1","ENSG00000105655","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways",1691.9,1756.9,1711.7,1564.4,1532.6,1571.4,1.1054108473995374,0.14458267490438478,1.9259678806504785E-3,2.7153509598763725,0.028698391626181177,1.5421424422014638,524]
["High","Q9NPJ8","NTF2-related export protein 2 [OS=Homo sapiens]",21,3,6,1,142,16.2,5.48,4.31,"transport","cytosol;nucleus;other cell component","","NXT2","ENSG00000101888","","","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; mRNA surveillance pathway; Amyotrophic lateral sclerosis; Influenza A",123.8,118.8,135.1,112.9,116.2,101.7,1.1417775090689237,0.1912815492688979,0.07450920452806498,1.1277900731735595,0.21380664055682888,0.6699788102946819,2721]
["High","Q9NQ66-1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [OS=Homo sapiens]",4,3,3,3,1216,138.5,6.23,2.5,"cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PLCB1","ENSG00000182621; ENSPPAG00000023075; ENSPTRG00000013241","AMP-activated protein kinase (AMPK) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; S1P receptor signal transduction; Cell-type dependent selectivity of CCK2R signaling; Chemokine signaling pathway; GPR40 pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; Fragile X syndrome; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; Alzheimer's disease","Ca2+ pathway; Synthesis of IP3 and IP4 in the cytosol; G alpha (q) signalling events; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Inositol phosphate metabolism; Metabolic pathways; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Apelin signaling pathway; Gap junction; Platelet activation; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Pathways in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis",12.6,16.1,20.8,13.1,12.1,12.8,1.3026315789473686,0.3814291066360243,0.18457874943607241,0.7338183007851802,0.37384977317687507,0.4273028785135205,3855]
["High","Q9NQC3","Reticulon-4 [OS=Homo sapiens]",46,30,150,22,1192,129.9,4.5,322.61,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","RTN4","ENSG00000115310","Alzheimer's disease and miRNA effects; Spinal cord injury; 22q11.2 copy number variation syndrome; Alzheimer's disease","Axonal growth inhibition (RHOA activation)","Alzheimer disease",3212.7,3033.6,3213.4,3013.1,2776.6,2854.9,1.0942900770423154,0.12999522189463394,0.041488686998469915,1.3820703091657784,0.15011291384803202,0.8235819448540349,2158]
["High","Q9NQG6","Mitochondrial dynamics protein MID51 [OS=Homo sapiens]",8,4,5,4,463,51.3,7.64,8.82,"cell organization and biogenesis;stress response;other biological processes","other membranes;mitochondrion","other molecular function","MIEF1","ENSG00000100335","","","",222.2,215.5,244.6,242.6,213.9,227.6,0.9973688057301563,-3.8010137232991907E-3,0.9627898646703681,0.016468490209325715,0.9821613879469865,0.00781714343917079,7654]
["High","Q9NQT5","exosome complex component RRP40 [OS=Homo sapiens]",36,5,15,5,275,29.6,8.1,39.12,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","EXOSC3","ENSG00000107371","","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","RNA degradation",428.7,468.6,450.9,473.8,501,448.6,0.9471687508781788,-0.07830661072874176,0.2581606094852818,0.5881100222873625,0.4560448051721901,0.34099248697781903,4420]
["High","Q9NQY0-1","Bridging integrator 3 [OS=Homo sapiens]",16,3,3,3,253,29.6,7.47,8.77,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","other molecular function","BIN3","ENSG00000147439; ENSGGOG00000002428; ENSPPAG00000028325; ENSPTRG00000020066","","","",195.4,181.6,243,187.7,189.7,196.4,1.0805158591843849,0.1117202473929356,0.4583325377141101,0.3388193104443008,0.6498384700330073,0.187194582266948,5507]
["High","Q9NR19-1","Acetyl-coenzyme A synthetase, cytoplasmic [OS=Homo sapiens]",5,4,9,3,701,78.5,6.46,19.43,"other metabolic processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","ACSS2","ENSG00000131069","Fatty acid beta-oxidation; Fatty acid biosynthesis; Lipid metabolism pathway; Ethanol effects on histone modifications; Fluoroacetic acid toxicity; Amino acid conjugation of benzoic acid","Transcriptional activation of mitochondrial biogenesis; Ethanol oxidation","Glycolysis / Gluconeogenesis; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism",344.9,336,350,395.1,384.7,408.8,0.8673229008918056,-0.20535889176557176,0.002892902180148812,2.5386662512257923,0.032974861638834924,1.4818170180595824,685]
["High","Q9NR45","sialic acid synthase [OS=Homo sapiens]",49,13,69,13,359,40.3,6.74,117.51,"other metabolic processes","cytosol;other cell component","other molecular function","NANS","ENSG00000095380","","Sialic acid metabolism","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",1924.4,1947.2,1931.9,1803.6,1802.8,1853.1,1.0630094330982691,0.08815439933722996,3.0737420270772415E-3,2.512332584760213,0.03366027734560884,1.472882309953443,713]
["High","Q9NRF8","CTP synthase 2 [OS=Homo sapiens]",37,19,50,15,586,65.6,6.9,98.28,"other metabolic processes","cytosol;other cell component","other molecular function","CTPS2","ENSG00000047230","Pyrimidine metabolism","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",1969.7,1961.8,1851.3,1878,2064.6,2035,0.967411670235546,-0.047798153248516634,0.4022846394987966,0.39546654985048824,0.6009256677265361,0.22117924528960337,5227]
["High","Q9NRG9-1","Aladin [OS=Homo sapiens]",37,14,30,14,546,59.5,7.5,74.13,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus","","AAAS","ENSG00000094914","","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; RHOA GTPase cycle; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; Regulation of HSF1-mediated heat shock response; Vpr-mediated nuclear import of PICs; Viral Messenger RNA Synthesis; tRNA processing in the nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Ribonucleoproteins into the Host Nucleus; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)","Nucleocytoplasmic transport",1141.9,1160.3,1134.1,1093.8,1229.3,1172.7,0.9829795754905886,-0.02476665456216414,0.6464343862912545,0.1894755498520565,0.7938596552629938,0.1002562687721752,6358]
["High","Q9NRN9","Methyltransferase-like protein 5 [OS=Homo sapiens]",16,2,7,2,209,23.7,6.68,4.94,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","METTL5","ENSG00000138382","","","",27.2,45.5,33.9,30.6,50.4,42.7,0.8617623282134195,-0.214638062217194,0.5084953077244804,0.29371305029043626,0.6921777131647041,0.15978238829154454,5736]
["High","Q9NRV9","Heme-binding protein 1 [OS=Homo sapiens]",66,11,41,11,189,21.1,5.8,79.41,"other biological processes","non-structural extracellular;other cell component","other molecular function","HEBP1","ENSG00000013583","","G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands","",2052.3,2153.8,2014.2,1773.3,1827.1,1773.1,1.1575881641388295,0.2111220760963818,3.3983761319360466E-3,2.468728555136171,0.0354265965796484,1.450670568177002,749]
["High","Q9NRX2","39S ribosomal protein L17, mitochondrial [OS=Homo sapiens]",9,2,3,2,175,20,10.11,7.03,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL17","ENSG00000158042","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",284.5,297.2,254.5,301.9,240,240.9,1.06821665815023,0.09520428741733358,0.5008280417984311,0.3003113625904076,0.6858059190393108,0.1637987709052134,5702]
["High","Q9NS69","Mitochondrial import receptor subunit TOM22 homolog [OS=Homo sapiens]",51,4,34,4,142,15.5,4.34,103.23,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity","TOMM22","ENSG00000100216","","PINK1-PRKN Mediated Mitophagy; Mitochondrial protein import","",1045.5,1025.1,1067.9,991.5,1037.9,1031,1.025519539929421,0.03635498074093419,0.24288047058288909,0.6146074043347042,0.4405135224880832,0.3560407554657423,4305]
["High","Q9NS91","E3 ubiquitin-protein ligase RAD18 [OS=Homo sapiens]",16,6,13,6,495,56.2,7.58,36.28,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD18","ENSG00000070950","SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Recognition of DNA damage by PCNA-containing replication complex; E3 ubiquitin ligases ubiquitinate target proteins","",800.4,820.7,860.7,777.2,848.4,820.3,1.0146776237785686,0.021021437311155147,0.6832236185502873,0.1654371288109092,0.8185683617677834,0.08694504514787321,6517]
["High","Q9NSG2-1","Uncharacterized protein C1orf112 [OS=Homo sapiens]",3,2,4,2,853,96.5,6,2.5,"","","","C1orf112","ENSG00000000460","","","",85.6,82.6,86.6,83.5,83.5,99.5,0.9560975609756097,-0.06477025539023788,0.5150325385047965,0.288165332421561,0.6977917856403697,0.15627414734428174,5763]
["High","Q9NSV4-3","Protein diaphanous homolog 3 [OS=Homo sapiens]",9,8,12,8,1193,136.8,7.03,20.5,"cell organization and biogenesis","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","DIAPH3","ENSG00000139734","Regulation of actin cytoskeleton","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; RHOC GTPase cycle; RHO GTPases Activate Formins; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","Regulation of actin cytoskeleton",358.4,362.8,385.1,282.5,299.9,297,1.2580168296565841,0.3311512226144077,1.5545613380694783E-3,2.8083921373972083,0.0261595149302726,1.5823703132934537,464]
["High","Q9NTK5-1","obg-like ATPase 1 [OS=Homo sapiens]",71,23,115,10,396,44.7,7.81,241.2,"other metabolic processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","translation activity;other molecular function","LOC111144733; Ola1; OLA1","ENSCCAG00000017844; ENSFCAG00000036661; ENSG00000138430; ENSLCNG00005010543; ENSMMUG00000007092; ENSMNEG00000040767; ENSMPUG00000013906; ENSNVIG00000008347; ENSPTRG00000012650; ENSRROG00000038551","","Platelet degranulation","",6128.4,6291.3,6307,6522.4,6300.6,6383.2,0.975034103570722,-0.03647541428983246,0.13767830960873226,0.8611344748428041,0.31114102501446644,0.5070427218943859,3455]
["High","Q9NTX7","E3 ubiquitin-protein ligase rnf146 [OS=Homo sapiens]",11,3,3,3,359,38.9,5.33,7.74,"cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RNF146","ENSG00000118518","","Ub-specific processing proteases; Degradation of AXIN; Regulation of PTEN stability and activity","",176.4,197.6,183.4,151.9,167.6,155,1.1747102212855638,0.23230491519533739,0.024647282453369897,1.6082309579513416,0.1091582424253614,0.9619434655920284,1763]
["High","Q9NUI1","Peroxisomal 2,4-dienoyl-CoA reductase [OS=Homo sapiens]",12,3,4,3,292,30.8,9.22,10.7,"other metabolic processes","other membranes;cytosol;other cytoplasmic organelle","other molecular function","DECR2","ENSG00000242612; ENSG00000274296","","Peroxisomal protein import; Beta-oxidation of very long chain fatty acids","Peroxisome",208.5,198.1,200.5,161.7,178.7,183.2,1.1594728800611156,0.2134690759055136,0.01857969346605244,1.730961455417733,0.09170053513460018,1.0376281299207553,1582]
["High","Q9NUQ3-1","Gamma-taxilin [OS=Homo sapiens]",35,16,29,16,528,60.5,7.52,53.28,"cell cycle OR cell proliferation;other biological processes","other membranes;cytosol;nucleus","other molecular function","TXLNG","ENSG00000086712","","","",984.1,979.5,866.4,954.4,869.7,834.6,1.0644299845789298,0.09008105620372746,0.3370995480836484,0.4722418296947188,0.5386969446248724,0.26865548767350134,4886]
["High","Q9NUQ6","SPATS2-like protein [OS=Homo sapiens]",4,3,4,3,558,61.7,9.64,2.15,"","cytosol;nucleus;other cell component","","SPATS2L","ENSG00000196141","","","",212.5,247.8,223.9,300.5,317.1,308.9,0.7384781435509985,-0.4373728721467281,0.002131343236674696,2.671346604818785,0.029611259772163744,1.5285431157292106,562]
["High","Q9NUY8","TBC1 domain family member 23 [OS=Homo sapiens]",14,7,14,7,699,78.3,5.41,30.47,"cell organization and biogenesis;transport;developmental processes","cytosol;ER/Golgi;other cell component","","TBC1D23","ENSG00000036054","","","",233.3,239.1,242.3,267,301,279.7,0.8431048720066062,-0.24621599881652706,0.012449384920785712,1.904852104962417,0.07297657467079192,1.136816525138064,1332]
["High","Q9NVA2-1","Septin-11 [OS=Homo sapiens]",40,17,85,7,429,49.4,6.81,191.24,"cell cycle OR cell proliferation;other biological processes","cytoskeleton;other cell component","other molecular function","Sept11; SEPT11; SEPTIN11","ENSANAG00000029750; ENSBTAG00000021372; ENSCATG00000027299; ENSCCAG00000022420; ENSCHIG00000021075; ENSCSAG00000004591; ENSFCAG00000027412; ENSG00000138758; ENSLCNG00005000771; ENSMFAG00000042066; ENSMMUG00000019901; ENSMNEG00000044831; ENSNLEG00000032040; ENSPCTG00005005661; ENSPPAG00000041700; ENSPTRG00000016192; ENSRBIG00000024343; ENSRROG00000038768; ENSSBOG00000020488; ENSSSUG00005020042; ENSUAMG00000017287","22q11.2 copy number variation syndrome","","Bacterial invasion of epithelial cells; Shigellosis",5175.6,5000.4,5186,5311.2,5342.6,5431.1,0.9550572275861212,-0.06634091202057865,0.0263512199082256,1.5791992746773433,0.11417887072332158,0.9424142566617522,1802]
["High","Q9NVF7-1","F-box only protein 28 [OS=Homo sapiens]",24,8,10,8,368,41.1,9.55,27.6,"protein metabolism;other metabolic processes","other cell component","other molecular function","FBXO28","ENSG00000143756; ENSGGOG00000010974; ENSPPAG00000034613; ENSPTRG00000002021","","","",385.3,391.6,392.2,396.3,359.6,395.8,1.0151081010679865,0.021633371322087914,0.6630639091845886,0.17844461025500186,0.8056649553241935,0.09384552681186575,6426]
["High","Q9NVI1-3","Fanconi anemia group I protein [OS=Homo sapiens]",30,35,82,35,1328,149.2,6.74,164.89,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","FANCI","ENSG00000140525","Gastric cancer network 2; DNA repair pathways, full network","TP53 Regulates Transcription of DNA Repair Genes; Fanconi Anemia Pathway","Fanconi anemia pathway",3543.5,3589.3,3513.7,3704.2,3794.7,3855.3,0.9376706417008683,-0.09284683208918917,0.008620026520218356,2.06449139803065,0.05993336337476841,1.2223313496334722,1123]
["High","Q9NVM4","Protein arginine N-methyltransferase 7 [OS=Homo sapiens]",15,7,9,7,692,78.4,5.57,20.75,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","PRMT7","ENSG00000132600","Nitric oxide metabolism in cystic fibrosis","RMTs methylate histone arginines","",231,225.8,225.8,224.8,213.2,218.3,1.0400731372847785,0.056684981335694475,0.08108881246166456,1.091039059738507,0.22531724117461813,0.6472055749849515,2810]
["High","Q9NVN3-1","Isoform 1 of Synembryn-B [OS=Homo sapiens]",12,4,7,4,536,60.8,5.88,11.38,"","","","RIC8B","","","","",218.9,215.6,201.3,201.6,168.2,171.9,1.1737123869300352,0.2310789256669236,0.057439586514486794,1.2407886950736091,0.18343079407162083,0.7365277538746127,2445]
["High","Q9NVS2","39S ribosomal protein S18a, mitochondrial [OS=Homo sapiens]",17,3,3,3,196,22.2,10.33,4.29,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS18A","ENSG00000096080","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",159.7,162.7,180.9,243.4,199.6,189.6,0.7956054378754346,-0.32987495802049194,0.0726477033489458,1.1387781107347905,0.2112600624761895,0.6751825961117296,2685]
["High","Q9NVX7-1","Kelch repeat and BTB domain-containing protein 4 [OS=Homo sapiens]",3,1,1,1,518,58.1,5.67,3.94,"","","","KBTBD4","ENSG00000123444; ENSG00000284900","","","",25.9,20.9,15.6,24.8,21.8,18.2,0.9629629629629631,-0.054447784022376135,0.831970862355724,0.07989188349258691,0.9109561763109653,0.04050251528179422,7131]
["High","Q9NVZ3","Adaptin ear-binding coat-associated protein 2 [OS=Homo sapiens]",28,6,14,6,263,28.3,8.38,33.44,"transport","plasma membrane;other membranes","","NECAP2","ENSG00000157191","","Cargo recognition for clathrin-mediated endocytosis","",752.7,799.6,745.4,630.4,689.2,610,1.1907649253731345,0.25188863194934663,0.01365703207932833,1.864643670465362,0.0769921346392748,1.1135536392071939,1385]
["High","Q9NW82","WD repeat-containing protein 70 [OS=Homo sapiens]",19,11,15,11,654,73.2,6.33,24.47,"other biological processes","nucleus;other cell component","other molecular function","WDR70","ENSG00000082068","","","",647.5,631.7,642,653.7,622.2,608.8,1.0193664774234625,0.027672815104855333,0.4365839869192145,0.35993219744080285,0.6324392893998566,0.1989811579689061,5390]
["High","Q9NWM8","Peptidyl-prolyl cis-trans isomerase FKBP14 [OS=Homo sapiens]",7,1,2,1,211,24.2,6.07,2.62,"protein metabolism;other metabolic processes","ER/Golgi","other molecular function","FKBP14","ENSG00000106080","","XBP1(S) activates chaperone genes","",33.5,34.1,37.8,33.6,32.9,28.1,1.1141649048625792,0.15596277829781938,0.17553594523889138,0.755633937771118,0.36306878421861294,0.4400110890776897,3775]
["High","Q9NWQ9","Uncharacterized protein C14orf119 [OS=Homo sapiens]",14,2,2,2,140,16,4.94,1.73,"","cytosol;mitochondrion","","C14orf119","ENSG00000179933","","","",94.3,96.1,97.5,91.1,90.4,85.2,1.0794900637420322,0.11034996401250824,0.02728953069995808,1.5640039328596402,0.11656272193942707,0.9334403195988175,1828]
["High","Q9NWX5","Ankyrin repeat and SOCS box protein 6 [OS=Homo sapiens]",7,2,2,2,421,47.1,6.01,7.64,"protein metabolism;other metabolic processes;signal transduction","cytosol","","ASB6","ENSG00000148331","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",126.8,124.8,119.5,87.3,91.2,80.4,1.4333719582850522,0.5194130357974147,6.1976842835191387E-4,3.207770550945685,0.017596915958442705,1.7545634401173122,275]
["High","Q9NWZ5-1","Uridine-cytidine kinase-like 1 [OS=Homo sapiens]",11,6,9,6,548,61.1,7.36,8.55,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","UCKL1","ENSG00000198276; ENSPPAG00000038781","Pyrimidine metabolism","Pyrimidine salvage","Pyrimidine metabolism; Drug metabolism; Metabolic pathways",289.4,308.7,274.9,292.2,312.6,299.1,0.9658148025224027,-0.05018151979881726,0.4202335278399546,0.3765093008710406,0.6167637942433017,0.20988112850745344,5320]
["High","Q9NX24","H/ACA ribonucleoprotein complex subunit 2 [OS=Homo sapiens]",18,2,4,2,153,17.2,8.22,11.53,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","NHP2","ENSG00000145912","","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","Ribosome biogenesis in eukaryotes",75,77.1,60.4,100.2,77.5,79.5,0.8262052877138413,-0.27542780141552103,0.17156084654601206,0.765581819454679,0.35778501330963197,0.44637785486211123,3744]
["High","Q9NX61","Transmembrane protein 161A [OS=Homo sapiens]",3,1,2,1,479,53.6,8.44,7.7,"stress response;other biological processes","other membranes","","TMEM161A","ENSG00000064545","","","",52.8,50.5,54.5,41.4,53.7,56.6,1.040210942649967,0.05687611976642508,0.6937038885375568,0.15882587106819104,0.8256768234300677,0.0831899057852159,6560]
["Medium","Q9NX76","CKLF-like MARVEL transmembrane domain-containing protein 6 [OS=Homo sapiens]",5,1,4,1,183,20.4,5.29,5.8,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","","CMTM6","ENSG00000091317","","Neutrophil degranulation","",71.4,59.3,60.7,47.5,50.5,49.8,1.294993234100135,0.3729445603398741,0.020826305245336293,1.681387770565434,0.09801795741747184,1.0086943519311595,1659]
["High","Q9NXF1","Testis-expressed protein 10 [OS=Homo sapiens]",15,13,34,13,929,105.6,9.36,68.49,"","mitochondrion;nucleus","","TEX10","ENSG00000136891","","Major pathway of rRNA processing in the nucleolus and cytosol","",958,1011.5,1096.5,1151.1,1066.3,1164.5,0.9065909695733169,-0.1414763040767428,0.10643203422037122,0.9729276371608073,0.2659268234216507,0.575237854182266,3125]
["High","Q9NXN4-1","Ganglioside-induced differentiation-associated protein 2 [OS=Homo sapiens]",9,3,3,3,497,56.2,5.74,4.92,"other biological processes","","","GDAP2","ENSG00000196505","","","",42.5,42,49.5,31.1,29,30.5,1.479028697571744,0.5646500452988997,4.4331001310940294E-3,2.3532924591156252,0.04110884302088145,1.3860647459566393,842]
["High","Q9NXS2","Glutaminyl-peptide cyclotransferase-like protein [OS=Homo sapiens]",2,2,3,2,382,42.9,9.82,6.22,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","QPCTL","ENSG00000011478","","","",191.2,180.1,180.9,178.5,169.9,204.1,0.9994570135746605,-7.8357657808714274E-4,0.9931037620981141,0.003005372902007383,0.9978322190788927,9.4247720354272483E-4,7771]
["High","Q9NY27","Serine/threonine-protein phosphatase 4 regulatory subunit 2 [OS=Homo sapiens]",60,17,47,17,417,46.9,4.54,107.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP4R2","ENSG00000163605","16p11.2 proximal deletion syndrome","Processing of DNA double-strand break ends","",1509.2,1567.4,1467.1,1770.6,1549,1720.9,0.9014383493701023,-0.1496992677881724,0.08634600725623867,1.0637577399340943,0.23376894058831885,0.6312131913228503,2884]
["High","Q9NYF3","protein FAM53C [OS=Homo sapiens]",3,1,2,1,392,43.1,8.65,4.74,"transport","nucleus","","FAM53C","ENSG00000120709","","","",34.9,32.7,31.4,30.8,23.1,21.3,1.3164893617021276,0.39669586328933454,0.06199786012519588,1.2076233000478325,0.19232391412694855,0.7159667109375598,2517]
["Medium","Q9NYG2-1","Palmitoyltransferase ZDHHC3 [OS=Homo sapiens]",3,1,2,1,299,34.1,8.18,0,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","ZDHHC3","ENSCCAG00000029642; ENSG00000163812","","","",43.8,43.9,40,38.3,35.5,46.2,1.0641666666666665,0.08972411920684269,0.49837288169912175,0.3024455972655162,0.6846051126507289,0.16455986186231286,5684]
["High","Q9NYP3-1","Protein downstream neighbor of son [OS=Homo sapiens]",11,4,5,4,566,62.7,8.66,3.66,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction","nucleus;other cell component","","DONSON","ENSG00000159147","","","",134.5,158.2,143.2,171.4,175.1,189.3,0.8135498320268756,-0.2976973774883818,0.01946262684474607,1.7107985439655697,0.09450509353468738,1.0245447837193666,1608]
["High","Q9NYU1","UDP-glucose:glycoprotein glucosyltransferase 2 [OS=Homo sapiens]",5,7,9,6,1516,174.6,6.89,9.87,"protein metabolism;other metabolic processes;stress response","ER/Golgi;other cell component","other molecular function","UGGT2","ENSG00000102595","","ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",150.7,176.2,142.6,143.7,138.2,155.5,1.0733882030178328,0.10217193749304378,0.3987158260964473,0.3993365256871221,0.5977675057912942,0.22346769658862226,5208]
["High","Q9NYZ3","G2 and S phase-expressed protein 1 [OS=Homo sapiens]",9,5,8,5,720,76.6,9.39,10.13,"cell cycle OR cell proliferation;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","GTSE1","ENSG00000075218","","The role of GTSE1 in G2/M progression after G2 checkpoint; G2/M Checkpoints","p53 signaling pathway",222.7,202.1,226.1,161,120,127.3,1.5941709527308352,0.6728063466637444,0.005305112386487923,2.2753054113263453,0.045419207800107136,1.3427604449961263,912]
["High","Q9NZ53-1","Podocalyxin-like protein 2 [OS=Homo sapiens]",2,1,2,1,605,65,4.34,2.38,"cell adhesion","plasma membrane;other membranes;ER/Golgi","other molecular function","PODXL2","ENSG00000114631","","Cytosolic sulfonation of small molecules","",18.3,21.8,22.2,19.8,21.4,21.1,0.9999999999999998,-3.2034265038149176E-16,1,0,1,0,7808]
["High","Q9NZ72","Stathmin-3 [OS=Homo sapiens]",13,3,3,2,180,21,7.49,5.11,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","STMN3","ENSG00000197457","","","",103.2,103.1,89.2,99.4,113.9,93.2,0.964110929853181,-0.05272894351324913,0.6586626059255358,0.18133699194209435,0.8028157394733975,0.09538412161126189,6406]
["High","Q9NZI7","Upstream-binding protein 1 [OS=Homo sapiens]",16,6,15,5,540,60.5,6.35,38.79,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBP1","ENSG00000153560","","","",499.4,504.6,460.6,396.2,476.4,406.4,1.145113369820172,0.19549043673331082,0.09798436252562116,1.0088432284985185,0.25316409748512575,0.5965978838428896,3022]
["High","Q9NZJ5","Eukaryotic translation initiation factor 2-alpha kinase 3 [OS=Homo sapiens]",14,10,17,10,1116,125.1,5.43,43.91,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","EIF2AK3","ENSG00000172071","Translation factors; Alzheimer's disease and miRNA effects; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; 7q11.23 copy number variation syndrome; Alzheimer's disease","Signaling by ALK fusions and activated point mutants; ALK mutants bind TKIs; PERK regulates gene expression","Mitophagy; Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Hepatitis C; Measles; Herpes simplex virus 1 infection; Lipid and atherosclerosis",594.7,674.9,661.3,552,588.1,584.2,1.1198167372267007,0.16326264841903992,0.06512851326401763,1.1862288356690445,0.19771517556977047,0.7039599952625935,2572]
["High","Q9NZM5","ribosome biogenesis protein NOP53 [OS=Homo sapiens]",15,5,9,5,478,54.4,10.32,18.47,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP53","ENSG00000105373","","","",341.8,290.2,291.2,482.2,288,403.3,0.7867064337452067,-0.3461027127650501,0.22960546164114848,0.6390177855580288,0.42492520609008944,0.3716875062812744,4219]
["High","Q9NZV5-1","Selenoprotein N [OS=Homo sapiens]",5,3,7,3,590,65.8,5.48,12.9,"cell organization and biogenesis;stress response;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SELENON","ENSG00000162430","Selenium micronutrient network","","",456.6,501.9,473.8,455.3,475,464.1,1.027180149168101,0.03868922695226777,0.4292466246554175,0.3672931111916007,0.6252906054681903,0.2039180962257353,5360]
["High","Q9P000-1","COMM domain-containing protein 9 [OS=Homo sapiens]",34,4,5,4,198,21.8,5.88,11.85,"transport;other biological processes","non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component","","COMMD9","ENSG00000110442","","Neddylation; Neutrophil degranulation","",279.4,326.8,282.9,318.6,346.4,345.2,0.8801227479706989,-0.18422334893392175,0.08527510995773585,1.0691777119204815,0.23215762153068392,0.6342170542576087,2868]
["High","Q9P0J0","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [OS=Homo sapiens]",43,5,31,5,144,16.7,8.43,47.91,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;mitochondrion;nucleus;other cell component","transporter activity;other molecular function","NDUFA13","ENSG00000186010","Nucleotide-binding oligomerization domain (NOD) pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",825.1,890.8,802.4,770.7,876.5,817.1,1.0219129164468612,0.031272260499434074,0.6796925448176412,0.1676874935944611,0.8165932281791264,0.087994225902897,6499]
["High","Q9P0N9","TBC1 domain family member 7 [OS=Homo sapiens]",29,6,8,6,293,34,7.94,12.97,"other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","TBC1D7","ENSG00000145979","Fragile X syndrome","TBC/RABGAPs","mTOR signaling pathway",223.3,235.6,219.5,212.3,220.6,209.6,1.055875486381323,0.07843971559459628,0.11151199532491275,0.9526784131250983,0.27302780166099677,0.563793127709422,3189]
["High","Q9P0S3","ORM1-like protein 1 [OS=Homo sapiens]",20,2,5,2,153,17.4,9.64,11.03,"other metabolic processes;other biological processes","other membranes;ER/Golgi","","ORMDL1","ENSG00000128699","","Sphingolipid de novo biosynthesis","",227.6,205,205.8,156.3,167.4,160.5,1.318463444857497,0.3988575722234094,3.1299997329524475E-3,2.504455699506997,0.03394310821512877,1.4692483912796297,720]
["High","Q9P1F3","Costars family protein ABRACL [OS=Homo sapiens]",16,1,3,1,81,9.1,6.29,3.27,"other biological processes","","","ABRACL","ENSG00000146386","","","",25.8,19.7,22.3,33.6,23.4,25.3,0.8238153098420412,-0.27960715728528196,0.250090400722208,0.6019029775753051,0.44807385241831116,0.3486503988269065,4358]
["High","Q9P1U1-1","Actin-related protein 3B [OS=Homo sapiens]",25,8,34,4,418,47.6,5.88,59.14,"","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTR3B","ENSCANG00000039781; ENSCATG00000043872; ENSCCAG00000019061; ENSCJAG00000019650; ENSCSAG00000006554; ENSG00000133627; ENSMFAG00000034566; ENSMMUG00000018920; ENSMNEG00000033219; ENSPANG00000006816; ENSPPYG00000018206; ENSPTRG00000019897; ENSRROG00000045018","","","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",348.9,339.9,358.1,366.9,355.7,356.8,0.9698906800074117,-0.04410594995789496,0.16313701989326515,0.7874474754341012,0.34783556835789575,0.45862601074114345,3662]
["High","Q9P219","Protein Daple [OS=Homo sapiens]",7,12,13,12,2028,228.1,6.23,29.23,"cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","CCDC88C","ENSG00000015133","Ectoderm differentiation; Ectoderm differentiation","Negative regulation of TCF-dependent signaling by DVL-interacting proteins","",747.3,627.4,692.6,760.2,734.4,758.8,0.9174136859856218,-0.12435566516935286,0.15686434644409322,0.8044757555981853,0.3396552459887632,0.468961673325933,3606]
["High","Q9P275","Ubiquitin carboxyl-terminal hydrolase 36 [OS=Homo sapiens]",15,14,22,14,1121,122.6,9.67,34.03,"","","","","","","","",1015.8,988.9,1018.8,1006.6,962.2,923.9,1.0452172710616379,0.06380286891055681,0.16524253739467057,0.7818781448014607,0.34965141788010506,0.45636470630188564,3690]
["High","Q9P2D3-1","HEAT repeat-containing protein 5B [OS=Homo sapiens]",7,9,13,9,2071,224.2,7.17,17.02,"transport;other biological processes","cytosol;other cell component","","HEATR5B","ENSG00000008869","","","",301.5,300.8,306.2,314,337.3,323.9,0.9316037735849056,-0.10221161149873392,0.033090125240412854,1.4803015891073792,0.1295076179835306,0.8877046844715109,1995]
["High","Q9P2E5-1","Chondroitin sulfate glucuronyltransferase [OS=Homo sapiens]",8,6,8,6,772,85.9,7.83,9.18,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHPF2","ENSG00000033100; ENSGGOG00000001088","","Chondroitin sulfate biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",541.8,559.6,551,513.3,499.6,500.1,1.0921348314606742,0.12715097775202092,0.002427589443522877,2.614824759725701,0.03077048437504322,1.511865667231491,616]
["High","Q9P2J5","Leucine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",48,52,268,52,1176,134.4,7.3,493.34,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","LARS1","ENSG00000133706","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",9406.8,9502.8,9380.4,9479,10019.8,9960.1,0.9603209895820958,-0.058411384183609916,0.09019053891074606,1.044839018049658,0.24026193374790353,0.6193150318294582,2931]
["High","Q9P2L0-1","WD repeat-containing protein 35 [OS=Homo sapiens]",7,5,9,5,1181,133.5,6.38,22.32,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","","WDR35","ENSG00000118965","Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",199.6,213.6,216.4,219,213.9,243.4,0.9309478042288927,-0.10322781291543116,0.21169817040590325,0.6742828953393689,0.4055297631327999,0.3919772660151223,4076]
["High","Q9P2R3","Rabankyrin-5 [OS=Homo sapiens]",16,15,25,14,1169,128.3,6.1,57.1,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ANKFY1","ENSG00000185722","","RHOD GTPase cycle","",1011.1,1119.5,970.6,849.8,905.7,827.2,1.2007588957292756,0.2639464967093854,0.026223402739369434,1.581310955092596,0.11400463729899585,0.943077482765246,1796]
["Medium","Q9P2Z0","THAP domain-containing protein 10 [OS=Homo sapiens]",4,1,2,1,257,28.3,8.6,5.18,"","","nucleic acid binding activity;other molecular function","THAP10","ENSG00000129028","","","",156.2,150.2,142.4,128.1,125.5,111.5,1.229252259654889,0.29778100717390815,0.012868202493776895,1.8904821136670218,0.0742608463203326,1.1292401056060093,1353]
["High","Q9UBB6","Neurochondrin [OS=Homo sapiens]",37,21,61,21,729,78.8,5.48,142.15,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","NCDN","ENSG00000020129","Splicing factor NOVA regulated synaptic proteins","","",1819.6,1892.9,1796.6,1543,1578.3,1610.8,1.164197713488726,0.21933608921477393,0.001782534371063718,2.7489620872716674,0.027670036519414534,1.5579902676689594,503]
["High","Q9UBF8-2","Isoform 2 of Phosphatidylinositol 4-kinase beta [OS=Homo sapiens]",5,3,3,3,801,89.8,6.44,4.63,"","","","PI4KB","","","","",76.4,65.7,82.5,70.1,59.8,81.5,1.0624408703878905,0.08738255101791846,0.6099167192628876,0.21472946143801808,0.7681015716136493,0.1145813462776366,6200]
["High","Q9UBM7","7-dehydrocholesterol reductase [OS=Homo sapiens]",21,10,65,10,475,54.5,8.7,99.19,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","DHCR7","ENSG00000172893","Vitamin D metabolism; Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol","Steroid biosynthesis; Metabolic pathways",2226.4,2285.7,2249,2208.4,2286.8,2263.9,{"$f":"AVERAGE(T7106:V7106)/AVERAGE(W7106:Y7106)","v":1.0002958973827878},{"$f":"LOG(Z7106,2)","v":4.2682654144549195E-4},{"$f":"TTEST(T7106:V7106,W7106:Y7106,2,2)","v":0.9827533183949788},{"$f":"-LOG10(AB7106)","v":0.007555481053337527},{"$f":"AB7106*7808/AF7106","v":0.9911312206184442},{"$f":"-LOG10(AD7106)","v":0.003868843377638404},7742]
["High","Q9UBP6","tRNA (guanine-N(7)-)-methyltransferase [OS=Homo sapiens]",26,6,13,6,276,31.5,7.64,38.11,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","METTL1","ENSG00000037897","","tRNA modification in the nucleus and cytosol","",611.1,584,629.3,681.9,677.4,688.5,0.8909073151674968,-0.1666527449622671,0.005342956574968884,2.2722183555434703,0.04554345517178717,1.3415740245526855,916]
["High","Q9UBQ6","Exostosin-like 2 [OS=Homo sapiens]",14,3,5,3,330,37.4,8.95,5.45,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EXTL2","ENSG00000162694","","XBP1(S) activates chaperone genes","Glycosaminoglycan biosynthesis; Metabolic pathways",285.8,315.6,245.6,230.4,290.9,256.2,1.0893890675241158,0.12351929431423378,0.43620498593926094,0.36030937462725726,0.6322421626533784,0.19911654551457678,5387]
["High","Q9UBU8-2","Isoform 2 of Mortality factor 4-like protein 1 [OS=Homo sapiens]",38,11,34,9,323,37.2,9.19,90.42,"","","","MORF4L1","","","","",1134.9,1076.5,1121.1,1198.4,1120.3,1180.8,0.9522788969852836,-0.07054393272902001,0.13216347029372252,0.8788885663491522,0.30342028110949293,0.517955393623239,3401]
["High","Q9UBV8","Peflin [OS=Homo sapiens]",7,2,12,2,284,30.4,6.54,19.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PEF1","ENSG00000162517","","","",425.3,446.8,399.9,445.8,433.2,405.9,0.9899603081951902,-0.014557412440480904,0.8225017058482965,0.0848631926609864,0.9043928065432333,0.043642900651096155,7101]
["High","Q9UDT6-2","Isoform 2 of CAP-Gly domain-containing linker protein 2 [OS=Homo sapiens]",26,25,49,1,1011,111.7,6.83,119.09,"","","","CLIP2","","","","",110.2,117.1,120,106.3,118,118.6,1.0128317293671625,0.018394506446457442,0.7816444228299921,0.10699076653377877,0.8795330239885544,0.0557478493654252,6939]
["High","Q9UDY2","Tight junction protein ZO-2 [OS=Homo sapiens]",33,31,97,1,1190,133.9,7.4,182.97,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","TJP2","ENSG00000119139","1q21.1 copy number variation syndrome","Signaling by Hippo; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Apoptotic cleavage of cell adhesion  proteins","Tight junction; Vibrio cholerae infection",3943.4,3664.8,3856.8,4749.9,4445.8,4686,0.8259074897166773,-0.2759479011377887,0.00288549175519005,2.5397801622773706,0.03293847898322209,1.4822964593388515,684]
["High","Q9UEG4","zinc finger protein 629 [OS=Homo sapiens]",13,7,11,5,869,96.6,7.93,17.83,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF629","ENSG00000102870","","","",204.4,197.3,216.3,219.9,205.6,224.5,0.9507692307692308,-0.07283288001144224,0.2504836962009492,0.6012205367843362,0.4484697775595073,0.3482668187991272,4361]
["High","Q9UG63","ATP-binding cassette sub-family F member 2 [OS=Homo sapiens]",23,15,41,15,623,71.2,7.37,64.83,"transport","","transporter activity;other molecular function","ABCF2","ENSG00000033050","VEGFA-VEGFR2 signaling pathway","","Pathogenic Escherichia coli infection",2403.3,2537.1,2437.2,2501.3,2367.3,2433.1,1.010394839557911,0.014919175905538973,0.6735590471682291,0.17162432609500605,0.8127258600354711,0.0900559212585781,6471]
["High","Q9UGN5-1","Poly [ADP-ribose] polymerase 2 [OS=Homo sapiens]",3,2,4,2,583,66.2,8.88,5.13,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP2","ENSG00000129484","NAD+ biosynthetic pathways; Base excision repair; Peroxiredoxin 2 induced ovarian failure; DNA repair pathways, full network","Dual Incision in GG-NER; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; HDR through MMEJ (alt-NHEJ); POLB-Dependent Long Patch Base Excision Repair","Base excision repair; Apoptosis",197.7,173.6,170.1,224.5,232.9,226.5,0.7916362041234098,-0.3370905018110257,0.006273310743755399,2.202503199477528,0.04987984754301645,1.3020748826058421,982]
["High","Q9UGU0","Transcription factor 20 [OS=Homo sapiens]",7,12,14,12,1960,211.6,9.04,29.68,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","TCF20","ENSG00000100207; ENSG00000262024; ENSG00000276461; ENSG00000280467; ENSG00000281897; ENSG00000282892; ENSG00000283026; ENSG00000283681","Matrix metalloproteinases","","",847.8,791.7,782.4,933.9,802.7,833.8,{"$f":"AVERAGE(T7170:V7170)/AVERAGE(W7170:Y7170)","v":0.9422268907563027},{"$f":"LOG(Z7170,2)","v":-0.08585358838868198},{"$f":"TTEST(T7170:V7170,W7170:Y7170,2,2)","v":0.3287266647116893},{"$f":"-LOG10(AB7170)","v":0.4831650666288559},{"$f":"AB7170*7808/AF7170","v":0.530528689141974},{"$f":"-LOG10(AD7170)","v":0.27529112599608135},4838]
["High","Q9UGY1","Nucleolar protein 12 [OS=Homo sapiens]",21,3,5,2,213,24.6,10.23,11.14,"","nucleus","nucleic acid binding activity;other molecular function","NOL12","ENSG00000273899","","Major pathway of rRNA processing in the nucleolus and cytosol","",70.3,81.8,58.8,88.3,66.4,73.3,0.9249999999999999,-0.11247472925841268,0.5717587545524079,0.24278717691851284,0.7403469909693533,0.1305646844000288,6030]
["High","Q9UHB7-1","AF4/FMR2 family member 4 [OS=Homo sapiens]",12,10,14,10,1163,127.4,9.31,27.56,"other biological processes","nucleus;other cell component","","AFF4","ENSG00000072364","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",373.9,337.4,353.8,391.7,341,365.7,0.9696831755280406,-0.04441464218287907,0.5717604172082135,0.24278591400616384,0.7402263865962081,0.13063543781848122,6031]
["High","Q9UHD2","Serine/threonine-protein kinase TBK1 [OS=Homo sapiens]",24,14,25,14,729,83.6,6.79,68.53,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;kinase activity;other molecular function","TBK1","ENSG00000183735","TNF-alpha signaling pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Toll-like receptor signaling pathway","Negative regulators of DDX58/IFIH1 signaling; Potential therapeutics for SARS; Interleukin-37 signaling; IRF3-mediated induction of type I IFN; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; TICAM1-dependent activation of IRF3/IRF7; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Regulation of innate immune responses to cytosolic DNA; STAT6-mediated induction of chemokines; IRF3 mediated activation of type 1 IFN","Ras signaling pathway; Mitophagy; Autophagy; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; IL-17 signaling pathway; Alcoholic liver disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Shigellosis; Yersinia infection; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis",1145.3,1159.5,1135.2,1145.1,1165.1,1113.1,1.0048783337715073,0.007020836836946094,0.7556724058817911,0.12166643618115495,0.8650183470348959,0.06297468105366766,6821]
["High","Q9UHI8","a disintegrin and metalloproteinase with thrombospondin motifs 1 [OS=Homo sapiens]",9,6,8,6,967,105.3,6.83,17.04,"cell organization and biogenesis;protein metabolism;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","other molecular function","ADAMTS1","ENSG00000154734","VEGFA-VEGFR2 signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Malignant pleural mesothelioma","Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins; Degradation of the extracellular matrix","",393.7,362.9,445,208.8,225.6,223.5,1.8264173886608908,0.8690165001195221,1.7871408119156857E-3,2.7478412273328017,0.027522673490015137,1.5603093820075025,507]
["High","Q9UHL0-1","ATP-dependent RNA helicase DDX25 [OS=Homo sapiens]",8,2,10,1,483,54.7,6.28,20.64,"other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX25","ENSG00000109832","","","",15.4,15.2,13.8,21.5,27.2,24,0.610729023383769,-0.7113956875694882,0.005435411973661417,2.2647675332506974,0.045585066262457945,1.3411774095734046,931]
["High","Q9UHQ4","B-cell receptor-associated protein 29 [OS=Homo sapiens]",27,8,13,8,241,28.3,9.54,25.33,"transport;other biological processes","other membranes;ER/Golgi","","BCAP29","ENSG00000075790; ENSG00000283852","","","",885.1,899.8,961.1,875.3,877.5,891.1,1.0386171942963047,0.0546640145366862,0.22582482615826105,0.6462283154187423,0.4215252791402587,0.3751763753407371,4183]
["High","Q9UHV7","mediator of RNA polymerase II transcription subunit 13 [OS=Homo sapiens]",0,1,1,1,2174,239.1,5.64,2.62,"other biological processes","nucleus","other molecular function","MED13","ENSG00000108510","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",58.5,52.6,52.4,70,59.8,53.1,0.893931109896118,-0.1617644393632717,0.28983256326814183,0.5378528222699743,0.49078565473815905,0.3091081398307465,4611]
["High","Q9UI10-1","translation initiation factor eIF-2B subunit delta [OS=Homo sapiens]",34,13,32,1,523,57.5,9.38,82.69,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF2B4","ENSG00000115211","Translation factors","Recycling of eIF2:GDP","Herpes simplex virus 1 infection",15.4,15.6,13.8,16,15.7,18.6,0.8906560636182902,-0.1670596677479231,0.16564879670147128,0.780811714552979,0.3500367536251929,0.4558863526251883,3695]
["High","Q9UI95","Mitotic spindle assembly checkpoint protein MAD2B [OS=Homo sapiens]",16,3,5,3,211,24.3,6.52,2.43,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD2L2","ENSG00000116670","Cell cycle","Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Bacterial invasion of epithelial cells",131.9,161.4,134,143.7,195.3,154.1,0.8665585074021497,-0.2066309358200074,0.2991180268505605,0.5241574126931653,0.5005386955956228,0.3005623424922637,4666]
["High","Q9UIF8-1","Bromodomain adjacent to zinc finger domain protein 2B [OS=Homo sapiens]",1,2,2,2,2168,240.3,6.54,6.12,"cell organization and biogenesis;other biological processes","nucleus","nucleic acid binding activity;other molecular function","BAZ2B","ENSG00000123636","","","",79.6,64.4,77.3,80.9,84.4,87.4,0.8757419865453107,-0.19142221314376345,0.10887746598525287,0.9630619954592796,0.2693647827670641,0.569659185338027,3156]
["High","Q9UIJ7-1","GTP:AMP phosphotransferase AK3, mitochondrial [OS=Homo sapiens]",65,13,42,13,227,25.6,9.16,65.5,"other metabolic processes;stress response","mitochondrion;other cell component","kinase activity;other molecular function","AK3","ENSG00000147853; ENSGGOG00000028122","","Factors involved in megakaryocyte development and platelet production","Purine metabolism; Biosynthesis of cofactors",1956,2044.3,1865.1,1848.2,1934.9,1893.2,1.0333139545126224,0.047278658658327734,0.33433339130551704,0.47582024639416765,0.5358118060988254,0.27098772136035115,4872]
["High","Q9UIW2","Plexin-A1 [OS=Homo sapiens]",10,16,21,13,1896,210.9,6.92,39.52,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","PLXNA1","ENSG00000114554","","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Sema3A PAK dependent Axon repulsion; RHOD GTPase cycle; RND1 GTPase cycle; CRMPs in Sema3A signaling; Other semaphorin interactions","Axon guidance",627.9,651,692.3,709.3,633.2,713.2,0.9588947803667852,-0.060555578049843115,0.4302975804352637,0.3662310959499053,0.62588738972402,0.20350379845220556,5368]
["Medium","Q9UJ99","Cadherin-22 [OS=Homo sapiens]",2,1,4,1,828,89,4.81,0,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CDH22","ENSG00000149654","Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Malignant pleural mesothelioma","","",28,23.1,31.7,34.4,34.2,25.6,0.8789808917197452,-0.18609629211345793,0.37651130061525084,0.4242219843472288,0.5782455222666952,0.23788772157056398,5084]
["High","Q9UJQ4","Sal-like protein 4 [OS=Homo sapiens]",19,14,33,13,1053,112.2,7.47,77.44,"cell cycle OR cell proliferation;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SALL4","ENSG00000101115","Vitamin D receptor pathway; Wnt/beta-catenin signaling pathway in leukemia","Regulation of PTEN gene transcription; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","",1790.5,1673.2,1701.3,2486.9,2293.8,2439.5,0.7153541453145342,-0.4832704513201539,5.465403503200439E-4,3.2623777691681877,0.017207205868140736,1.7642896453357684,248]
["High","Q9UJU6-2","Isoform 2 of Drebrin-like protein [OS=Homo sapiens]",47,15,51,1,431,48.3,5.05,132.53,"","","","DBNL","","","","",92.2,85.1,94.8,96.5,94.1,123.9,0.8651828298887123,-0.2089230605169728,0.22999188948293148,0.6382874788298605,0.42543868113781785,0.3711630263256332,4221]
["High","Q9UJX4","Anaphase-promoting complex subunit 5 [OS=Homo sapiens]",21,11,18,11,755,85,6.87,38.35,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ANAPC5","ENSG00000089053","Cell cycle","Separation of Sister Chromatids; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of APC/C activators between G1/S and early anaphase; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; IL-17 signaling pathway; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection",372.5,409.3,380.2,335.2,353.3,360.2,1.1080385238867168,0.14800804136377008,0.04851052341377677,1.3141640394434342,0.16518541945694246,0.7820282895147376,2293]
["High","Q9UJZ1","Stomatin-like protein 2, mitochondrial [OS=Homo sapiens]",67,18,146,18,356,38.5,7.39,292.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","signal transduction activity or receptor binding;other molecular function","STOML2","ENSG00000165283","","Processing of SMDT1","",3151.1,3050.2,3175.4,3096.2,3146.5,3094,1.0042841689247806,6.16754726810184E-3,0.7667240160246792,0.11536093316525459,0.8706487953927713,0.060156996521633976,6876]
["High","Q9UK58","Cyclin-L1 [OS=Homo sapiens]",9,3,4,3,526,59.6,10.7,9.86,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","enzyme regulator activity","CCNL1","ENSG00000163660","","","",150.6,166.3,162,203.9,185.9,182.8,0.8363604610548375,-0.25780323476335193,0.018027052328075006,1.7440752806157847,0.09022770806257029,1.044660074311611,1560]
["High","Q9UKA9-1","Polypyrimidine tract-binding protein 2 [OS=Homo sapiens]",27,8,38,1,531,57.5,8.66,69.19,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","LOC101350812; PTBP2","ENSANAG00000033752; ENSCSAG00000001494; ENSG00000117569; ENSMMUG00000016130; ENSPANG00000001229; ENSPPYG00000001132","Genes targeted by miRNAs in adipocytes; mRNA processing","","",409.1,407.7,408.5,570.5,622.8,588.8,0.6875596206722406,-0.5404432748626837,2.6687286214685209E-4,3.5736955866437126,0.013272250367150453,1.8770554343943107,157]
["High","Q9UKF6","Cleavage and polyadenylation specificity factor subunit 3 [OS=Homo sapiens]",21,11,23,11,684,77.4,5.6,59.14,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","CPSF3","ENSG00000119203","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript","mRNA surveillance pathway",541.7,559.9,515.2,503.5,569.5,556.7,0.992084432717678,-0.01146518649345449,0.866602829097844,0.0621798975084558,0.9290724824380017,0.03195040280409082,7283]
["High","Q9UKK3","Poly [ADP-ribose] polymerase 4 [OS=Homo sapiens]",3,3,3,3,1724,192.5,5.66,3.75,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP4","ENSG00000102699","NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome","Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein","Base excision repair; Apoptosis",45.9,47.5,52.9,44.9,54.9,42.5,1.028109627547435,0.039994107612004566,0.7743899231480725,0.11104030697763365,0.8747738020746745,0.05810423178983514,6912]
["High","Q9UKM9-2","Isoform 1 of RNA-binding protein Raly [OS=Homo sapiens]",55,14,62,14,290,30.3,9.63,140.27,"","","","RALY","","","","",3054,3124.7,2846.8,2984.4,3262.8,3063.6,0.9693581647119474,-0.044898274467837035,0.46379059224915575,0.33367806504627856,0.6542505771059455,0.18425588560238473,5535]
["High","Q9UKU7","Isobutyryl-CoA dehydrogenase, mitochondrial [OS=Homo sapiens]",9,4,5,4,415,45,7.85,8.28,"other metabolic processes","mitochondrion","other molecular function","ACAD8","ENSG00000151498","","Branched-chain amino acid catabolism","Valine, leucine and isoleucine degradation; Metabolic pathways",294.9,335.3,283.7,270.5,325.3,310.2,1.008719646799117,0.012525262280030112,0.9130149278510783,0.039522121665755514,0.9539436045311414,0.02047729926328906,7473]
["High","Q9UKW4","Guanine nucleotide exchange factor VAV3 [OS=Homo sapiens]",4,4,6,3,847,97.7,7.05,14.63,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;cytosol","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","VAV3","ENSG00000134215","Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mesodermal commitment pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; T-cell receptor (TCR) signaling pathway","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOG GTPase cycle; RAC2 GTPase cycle; FCERI mediated Ca+2 mobilization; FCERI mediated MAPK activation; DAP12 signaling; EPH-ephrin mediated repulsion of cells; GPVI-mediated activation cascade; VEGFR2 mediated vascular permeability","Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Yersinia infection; Proteoglycans in cancer; Lipid and atherosclerosis",164.4,143,148.5,173.4,154,155.4,0.9442833471416737,-0.08270826689025619,0.37332468301921273,0.42791329497951625,0.5747080293797344,0.24055273519455714,5072]
["High","Q9UL15-1","BAG family molecular chaperone regulator 5 [OS=Homo sapiens]",27,9,18,9,447,51.2,6.05,33.98,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","BAG5","ENSG00000166170","","Regulation of HSF1-mediated heat shock response","",516.8,474.3,499.4,468.1,467.7,497.3,1.040053031888912,0.05665709268610937,0.29137492002217813,0.5355478326783389,0.4927562000288427,0.30736790257084473,4617]
["High","Q9UL63-1","muskelin [OS=Homo sapiens]",21,11,18,11,735,84.7,6.34,26.5,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","MKLN1","ENSG00000128585","Ciliary landscape","","",667,676.5,671.4,647.2,669.9,593.8,1.0544246166727722,0.07645595711373146,0.20179279457853613,0.6950943451885505,0.3934077752981798,0.40515706095017157,4005]
["High","Q9ULD9","zinc finger protein 608 [OS=Homo sapiens]",2,3,6,2,1512,162.1,8.79,11.89,"other biological processes","nucleus","other molecular function","ZNF608","ENSG00000168916","","","",142.8,164.1,161.8,231.7,146.9,186.2,0.8298512747875354,-0.26907529379215606,0.2760210116265767,0.5590578567530871,0.4759655606846977,0.32242447027466664,4528]
["High","Q9ULH1-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",3,3,5,3,1129,125.4,7.31,9.77,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ASAP1","ENSG00000153317","EGF/EGFR signaling pathway; CCL18 signaling pathway","VxPx cargo-targeting to cilium","Endocytosis; Fc gamma R-mediated phagocytosis",67.4,88.8,90.8,60.1,55.7,54.6,1.4495305164319248,0.5355857062462016,0.029193795156755124,1.5347094436040005,0.12124742158720427,0.9163274882090451,1880]
["High","Q9ULJ7-1","Ankyrin repeat domain-containing protein 50 [OS=Homo sapiens]",5,5,7,5,1429,155.8,6.6,20.17,"transport","other cytoplasmic organelle","","ANKRD50","ENSG00000151458","","","",262.8,285.7,252.8,250,249.1,231.2,1.0972203204162672,0.13385324612156713,0.10875466776250588,0.9635520940055545,0.26914625860210645,0.5700116529270722,3155]
["High","Q9ULT8","E3 ubiquitin-protein ligase hectd1 [OS=Homo sapiens]",16,39,61,39,2610,289.2,5.35,119.59,"protein metabolism;other metabolic processes;developmental processes;other biological processes","","other molecular function","HECTD1","ENSG00000092148","","Antigen processing: Ubiquitination & Proteasome degradation","",2687.6,2574,2654.4,3027.1,3051.4,3065.9,0.8656664187918288,-0.20811689980593387,3.2523982009397744E-4,3.487796287836938,0.014108180640520976,1.850528988281609,180]
["High","Q9ULV0","unconventional myosin-Vb [OS=Homo sapiens]",3,6,6,2,1848,213.5,7.2,9.72,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5B","ENSG00000167306","","Vasopressin regulates renal water homeostasis via Aquaporins","Pathogenic Escherichia coli infection",100.2,91.3,82.7,82.1,83.1,77.7,1.128859613009469,0.174866081143361,0.12125924573777136,0.9162851375107719,0.28795382929456165,0.5406771417201494,3288]
["High","Q9ULZ3","apoptosis-associated speck-like protein containing a CARD [OS=Homo sapiens]",50,10,31,10,195,21.6,6.34,70.96,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PYCARD","ENSG00000103490","Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling","Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; CLEC7A/inflammasome pathway","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Lipid and atherosclerosis",1325.2,1415.5,1327,1406.9,1586.6,1556.9,0.8939214135021096,-0.1617800882374014,0.06330450278335492,1.1985653979697688,0.19513681710715958,0.7096607831016815,2533]
["High","Q9UM47","Neurogenic locus notch homolog protein 3 [OS=Homo sapiens]",4,8,13,6,2321,243.5,5.39,17.82,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","NOTCH3","ENSG00000074181","Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; OSX and miRNAs in tooth development; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Neovascularisation processes; Osteoblast differentiation and related diseases; Notch signaling pathway","Pre-NOTCH Transcription and Translation; Pre-NOTCH Processing in Golgi; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Pre-NOTCH Processing in the Endoplasmic Reticulum; Defective LFNG causes SCDO3; Noncanonical activation of NOTCH3","Endocrine resistance; Notch signaling pathway; Apelin signaling pathway; Th1 and Th2 cell differentiation; Thyroid hormone signaling pathway; Human papillomavirus infection; Pathways in cancer; MicroRNAs in cancer; Breast cancer",297.6,289.1,314.7,352.3,331.8,343.6,0.8771042132918168,-0.18917982796748747,0.011779960264132389,1.9288561744977408,0.07163390166849352,1.14488139357194,1284]
["Medium","Q9UN36-1","Protein NDRG2 [OS=Homo sapiens]",4,2,2,1,371,40.8,5.21,3.96,"cell-cell signaling;signal transduction;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","NDRG2","ENSG00000165795","","","",62.6,53.4,57.9,69,65.9,64.5,0.8721163490471414,-0.1974074770916088,0.04584897785062368,1.3386703419739394,0.1597451222925791,0.7965723938503652,2241]
["Low","Q9UNA0","A disintegrin and metalloproteinase with thrombospondin motifs 5 [OS=Homo sapiens]",1,1,1,1,930,101.7,8.85,0,"cell organization and biogenesis;protein metabolism;stress response;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi","signal transduction activity or receptor binding;other molecular function","ADAMTS5","ENSG00000154736","Vitamin D receptor pathway; Endochondral ossification; IL-18 signaling pathway; Endochondral ossification with skeletal dysplasias","Degradation of the extracellular matrix; Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins","",398.6,495.8,284,263,408,316.8,1.1929540392792064,0.2545384616574051,0.4413465130942936,0.3552203002534623,0.6365041696047736,0.1961987470293145,5414]
["High","Q9UNE7-1","E3 ubiquitin-protein ligase CHIP [OS=Homo sapiens]",29,8,13,8,303,34.8,5.87,33.16,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","STUB1","ENSCATG00000030791; ENSCSAG00000012299; ENSG00000103266; ENSGGOG00000043504; ENSMFAG00000031388; ENSMNEG00000033024; ENSPPAG00000028029; ENSPPYG00000006921; ENSPTRG00000007553; ENSRBIG00000029383; ENSRROG00000037882","Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway; Androgen receptor signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Downregulation of TGF-beta receptor signaling","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",574.5,617.5,471.7,513.9,456.7,471,1.1540649278579358,0.20672439249607777,0.1868922753651448,0.7284086485174815,0.3764847487231813,0.4242526122375738,3876]
["High","Q9UNL2","Translocon-associated protein subunit gamma [OS=Homo sapiens]",15,4,14,4,185,21.1,9.61,35.32,"transport","other membranes;ER/Golgi","","SSR3","ENSG00000114850","VEGFA-VEGFR2 signaling pathway","SRP-dependent cotranslational protein targeting to membrane","Protein processing in endoplasmic reticulum",600.2,614.8,558.8,554.9,559.8,517.4,1.086820660498744,0.12011389661636467,0.09257156726898345,1.0335223834511276,0.24353059206072195,0.6134464753994816,2968]
["High","Q9UNN8","Endothelial protein C receptor [OS=Homo sapiens]",5,1,3,1,238,26.7,7.18,4.91,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","PROCR","ENSG00000101000","","Cell surface interactions at the vascular wall; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",28.2,24.3,24.5,37.7,41.4,38.3,0.6558773424190801,-0.6085020575277884,1.4036747217654293E-3,2.8527335210589038,0.025370120897093687,1.5956774632151804,432]
["High","Q9UNY4-1","transcription termination factor 2 [OS=Homo sapiens]",27,25,46,25,1162,129.5,8.37,93.56,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","TTF2","ENSG00000116830","Thyroid stimulating hormone (TSH) signaling pathway; Thyroid hormones production and peripheral downstream signaling effects","","Thyroid hormone synthesis",1676.3,1565.9,1703.4,1700.7,1670.2,1683.4,0.978493559939062,-0.03136573925710563,0.44655646312027564,0.3501236206024668,0.6403513065276606,0.19358170003562522,5445]
["High","Q9UPN9-1","E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",34,27,62,2,1127,122.5,6.67,131.34,"protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TRIM33","ENSG00000197323","Ectoderm differentiation","Downregulation of SMAD2/3:SMAD4 transcriptional activity","",2521.1,2501.4,2595.7,2825.6,2766.3,2800.2,0.907782319085807,-0.13958170576955875,1.5239527580642527E-3,2.8170284957457716,0.026037249748283774,1.5844048911569864,457]
["High","Q9UPN9-2","Isoform Beta of E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",33,26,63,1,1110,120.5,6.67,137.02,"","","","TRIM33","","","","",164.1,150.3,181.2,179.3,181.5,154.5,0.9617698428100137,-0.056236405012427264,0.6255762897484544,0.20371972002900823,0.7807704076655901,0.1074766554221644,6256]
["High","Q9UPT8","Zinc finger CCCH domain-containing protein 4 [OS=Homo sapiens]",18,15,42,14,1303,140.2,6.27,67.32,"other biological processes","cytosol;nucleus","other molecular function","ZC3H4","ENSG00000130749","","","",1043.4,687.4,946.2,1307.1,1024,1127.4,0.7740349862657222,-0.36952931744362083,0.12511926933025677,0.9026758004636081,0.2935490549671409,0.532319313423659,3328]
["High","Q9UPX8","SH3 and multiple ankyrin repeat domains protein 2 [OS=Homo sapiens]",5,7,7,7,1470,158.7,6.9,10.03,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","SHANK2","ENSG00000162105","","Neurexins and neuroligins","Glutamatergic synapse",309,306.6,316,375.1,311.3,312.2,0.9329060684958942,-0.10019626711922656,0.3536891461992261,0.4513782673498211,0.5556549001053435,0.25519485142451787,4970]
["High","Q9UPY8","Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",10,3,7,1,281,32,5.54,11.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAPRE3","ENSG00000084764","","","",113.9,127.7,100.3,118.7,134.9,131.4,0.8880519480519481,-0.1712840230362315,0.1978947653140623,0.7035656935413791,0.3895039898089736,0.4094880893568943,3967]
["High","Q9UQB3-1","Catenin delta-2 [OS=Homo sapiens]",3,3,3,3,1225,132.6,7.74,2.46,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","CTNND2","ENSG00000169862; ENSPTRG00000016731","Ectoderm differentiation; Ectoderm differentiation","","Wnt signaling pathway",43.9,53.4,43.3,44.2,48.1,48.6,0.9978708303761533,-3.075017237101282E-3,0.9789043701942037,0.009259732635591739,0.9892939842708184,4.6746317857578636E-3,7726]
["High","Q9Y217-1","Myotubularin-related protein 6 [OS=Homo sapiens]",8,4,6,4,621,71.9,7.66,13.34,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","MTMR6","ENSG00000139505; ENSPPAG00000035079","","Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",185.8,186.2,200.9,231.8,215.4,233.3,0.8418809698750919,-0.24831182395915913,9.117900599230809E-3,2.0401051466636533,0.06179910406145325,1.2090178210922113,1152]
["High","Q9Y230","RuvB-like 2 [OS=Homo sapiens]",62,26,112,26,463,51.1,5.64,212.05,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","RUVBL2","ENSG00000183207","","HATs acetylate histones; Telomere Extension By Telomerase","",5183.1,5351.8,5099.8,4957.2,5298.5,4988.3,1.0256297559695617,0.03651002370636668,0.37896402312245775,0.42140201773912167,0.580072748978661,0.2365175366116732,5101]
["High","Q9Y250","Leucine zipper putative tumor suppressor 1 [OS=Homo sapiens]",17,8,9,8,596,66.6,7.09,14.92,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;other cell component","cytoskeletal activity","LZTS1","ENSG00000061337","","","",348.9,331.9,332.4,454.7,340.2,348.4,0.886206594944459,-0.17428503182082347,0.3095716597866336,0.5092388043251951,0.5098366419772274,0.2925689549855163,4741]
["High","Q9Y277","Voltage-dependent anion-selective channel protein 3 [OS=Homo sapiens]",51,12,51,10,283,30.6,8.66,130.66,"transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","VDAC3","ENSG00000078668","Alzheimer's disease and miRNA effects; Ferroptosis; Hepatitis B infection; Alzheimer's disease","Ub-specific processing proteases; Mitochondrial calcium ion transport","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Hepatitis B; Human T-cell leukemia virus 1 infection; Viral carcinogenesis; Chemical carcinogenesis; Diabetic cardiomyopathy",2102.8,2202.9,1931.2,1689.9,2199.8,2002.9,1.0584292163051963,0.08192479064917117,0.532797907851145,0.27343748918776845,0.7114906900122696,0.14783077836641687,5847]
["High","Q9Y282-1","Endoplasmic reticulum-Golgi intermediate compartment protein 3 [OS=Homo sapiens]",24,10,20,10,383,43.2,6.06,39.07,"transport","other membranes;ER/Golgi;other cell component","","ERGIC3","ENSCANG00000036642; ENSCATG00000041920; ENSG00000125991; ENSGGOG00000027615; ENSMFAG00000037850; ENSMLEG00000032774; ENSMNEG00000030061; ENSPANG00000011730; ENSPPAG00000037078; ENSPTRG00000013442; ENSRROG00000033106","","","",660.6,655.8,761.4,732.2,745.9,739.5,0.9369588744588746,-0.09394236921882892,0.24991138715560884,0.6022139548932528,0.4478558895825095,0.3488617101703714,4357]
["High","Q9Y2B1","UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase [OS=Homo sapiens]",5,2,2,2,443,51.1,8.32,4.19,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus","other molecular function","RXYLT1","ENSG00000118600","","","Mannose type O-glycan biosynthesis; Metabolic pathways",145.9,155,152,131.7,123.3,139.8,1.147163120567376,0.19807054959371415,0.02392151935843456,1.6212112398998142,0.10679200866246828,0.9714612447198553,1749]
["High","Q9Y2F5","Little elongation complex subunit 1 [OS=Homo sapiens]",4,7,7,7,2266,247.7,5.48,11.53,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","ICE1","ENSG00000164151","","RNA polymerase II transcribes snRNA genes","",202.7,197.6,187.8,175.2,191.7,180.7,1.0739590942293644,0.10293904390403227,0.10755269144309482,0.9683787171755511,0.2671878507119581,0.5731832935344957,3143]
["High","Q9Y2G8","DnaJ homolog subfamily C member 16 [OS=Homo sapiens]",16,8,14,8,782,90.5,7.12,37.2,"","other membranes","","DNAJC16","ENSG00000116138","","","",468.3,524,483.7,470.6,453.3,486.1,1.0468085106382978,0.06599755877424009,0.31395222450070365,0.5031364354119454,0.5147708880515527,0.28838602182217116,4762]
["Medium","Q9Y2I8","WD repeat-containing protein 37 [OS=Homo sapiens]",1,1,1,1,494,54.6,7.23,2.3,"","nucleus;other cell component","","WDR37","ENSG00000047056","","","",81.7,101.9,86.9,123.8,92.6,99.7,0.8557418538437205,-0.22475244119032065,0.24685975530280568,0.607549705833694,0.44504293913745246,0.351598084904901,4331]
["High","Q9Y2J4","Angiomotin-like protein 2 [OS=Homo sapiens]",6,4,4,4,779,85.7,7.3,6.13,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","AMOTL2","ENSG00000114019","","Signaling by Hippo","Tight junction",224.7,181.5,216.6,164.7,135.5,160.4,1.3521493703864524,0.4352545332861914,0.02825070834100051,1.5489706584735285,0.11897601441560517,0.9245405836233714,1854]
["High","Q9Y2R0","Cytochrome c oxidase assembly factor 3 homolog, mitochondrial [OS=Homo sapiens]",26,3,6,3,106,11.7,9.6,12.73,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion","","COA3","ENSG00000183978","Mitochondrial complex IV assembly","","Thermogenesis",208.8,248,192.1,201.8,219.1,201.9,1.041907514450867,0.0592272216040977,0.6458401124266868,0.18987498492342947,0.7932546166159463,0.10058739169525108,6357]
["High","Q9Y2R9","28S ribosomal protein S7, mitochondrial [OS=Homo sapiens]",17,3,5,3,242,28.1,9.99,8.48,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS7","ENSG00000125445","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",266.5,273,266.7,291,239.7,233.2,1.055373740018327,0.07775399171675684,0.4863076585603934,0.3130888909411216,0.6746784289338222,0.17090317504519428,5628]
["High","Q9Y2V7-1","Conserved oligomeric Golgi complex subunit 6 [OS=Homo sapiens]",10,7,11,7,657,73.2,5.76,22.47,"other metabolic processes;transport","other membranes;ER/Golgi","","COG6","ENSG00000133103","","COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",502.9,551.2,495.6,453.7,555.3,503.2,1.024798307102235,0.03533999755914929,0.7327141032630469,0.13506544909103257,0.8512173364496162,0.06995953983317643,6721]
["High","Q9Y2Y0","ADP-ribosylation factor-like protein 2-binding protein [OS=Homo sapiens]",34,5,13,5,163,18.8,4.35,32,"signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","ARL2BP","ENSG00000102931","Ciliopathies","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane","",444.1,449.1,454.3,415.8,399.3,366.9,1.1400169204737733,0.1890552374623355,0.019729113629506172,1.7048924258710474,0.09526587459442436,1.0210626411188133,1617]
["Low","Q9Y2Z2","Protein MTO1 homolog, mitochondrial [OS=Homo sapiens]",1,1,1,1,717,79.9,8.31,0,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","MTO1","ENSG00000135297","","tRNA modification in the mitochondrion","",12,16.7,17.5,18.4,15.4,18.1,0.8901734104046243,-0.16784168694182328,0.3878996427614571,0.41128062036591245,0.5877586669282858,0.23080095816835183,5153]
["High","Q9Y2Z4","Tyrosine--tRNA ligase, mitochondrial [OS=Homo sapiens]",45,17,69,17,477,53.2,8.98,146.02,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","YARS2","ENSG00000139131","Orexin receptor pathway","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",2288.7,2412.4,2242.9,2482.8,2645.9,2555.6,0.9036607107999425,-0.1461468960601419,0.023455234317849766,1.629760224092186,0.10555531386384494,0.9765198985604431,1735]
["Medium","Q9Y2Z9-1","Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [OS=Homo sapiens]",2,1,1,1,468,50.8,7.3,0,"other metabolic processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","COQ6","ENSG00000119723","Nephrotic syndrome","Ubiquinol biosynthesis","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",38.5,48.8,38.7,41.1,45.2,42.8,0.9759876065065839,-0.035065266919912075,0.7884793720095072,0.10320966408476673,0.883531420299976,0.053778001425738096,6968]
["High","Q9Y303","N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",16,5,6,5,409,43.7,6.7,13.48,"other metabolic processes","cytosol","other molecular function","AMDHD2","ENSG00000162066","","Synthesis of UDP-N-acetyl-glucosamine","Amino sugar and nucleotide sugar metabolism; Metabolic pathways",166.2,176.2,164.8,208.8,215.4,176.8,0.8439267886855241,-0.24481024545914062,0.06594109477313755,1.1808438468503462,0.19909824748207963,0.7009325627360862,2586]
["High","Q9Y305-1","Acyl-coenzyme A thioesterase 9, mitochondrial [OS=Homo sapiens]",31,12,33,12,439,49.9,8.6,73.44,"other metabolic processes","mitochondrion","other molecular function","ACOT9","ENSG00000123130","VEGFA-VEGFR2 signaling pathway","Mitochondrial Fatty Acid Beta-Oxidation","",1153.2,1130.5,1122.6,1140.4,1213.4,1196.2,0.9595211267605633,-0.05961352282090858,0.1151872363273171,0.9385956415700882,0.2785326544576314,0.5551238819286145,3229]
["High","Q9Y312","Protein AAR2 homolog [OS=Homo sapiens]",29,8,27,8,384,43.4,5.96,31.97,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","","AAR2","ENSG00000131043","Ciliary landscape","","",467.5,469.9,497.3,418.8,379.8,402.4,1.1945878434637802,0.25651294560662796,0.00624682279909244,2.2043408133220814,0.04982144271227147,1.3025837004665837,979]
["High","Q9Y314","nitric oxide synthase-interacting protein [OS=Homo sapiens]",47,9,14,9,301,33.2,8.82,34.49,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","NOSIP","ENSG00000142546","","NOSIP mediated eNOS trafficking","",587.3,587.5,543.9,493.9,478.2,470.3,1.1915557404326125,0.2528464417210126,0.00459344930207492,2.337861072572851,0.041801459382984824,1.3788085557629208,858]
["High","Q9Y315","deoxyribose-phosphate aldolase [OS=Homo sapiens]",31,9,19,9,318,35.2,8.94,32.66,"other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","DERA","ENSG00000023697","Pentose phosphate pathway in senescent cells","Neutrophil degranulation; Pentose phosphate pathway","Pentose phosphate pathway; Metabolic pathways",687.9,766,706.5,704.3,767.4,756.5,0.9695718517188764,-0.04458027930160144,0.5006433259756442,0.30047156899479954,0.6859138601891261,0.16373042130999468,5699]
["High","Q9Y316-1","Protein MEMO1 [OS=Homo sapiens]",21,5,11,5,297,33.7,7.14,22.28,"other biological processes","","other molecular function","LOC111154137; LOC114499315; MEMO1","ENSANAG00000021250; ENSCANG00000020056; ENSCATG00000030724; ENSCCAG00000037443; ENSCHIG00000006439; ENSCJAG00000003208; ENSDLEG00000015222; ENSECAG00000019946; ENSFCAG00000001385; ENSG00000162959; ENSHGLG00000018935; ENSMMUG00000003908; ENSMNEG00000040106; ENSMODG00000047380; ENSPANG00000022798; ENSPCOG00000018130; ENSPCTG00005009736; ENSPTRG00000050445; ENSRFEG00010015180; ENSSSCG00000008515; ENSSSCG00070008027; ENSVURG00010020209; ENSVVUG00000007616","","ERBB2 Regulates Cell Motility; ERBB2 Regulates Cell Motility","",552.1,547.8,529.8,587.9,533.6,570,0.9634643807271652,-0.05369676380816097,0.3013791327458616,0.520886821188802,0.5017416350702958,0.2995198592452499,4690]
["High","Q9Y320","Thioredoxin-related transmembrane protein 2 [OS=Homo sapiens]",29,7,29,7,296,34,8.69,56.44,"developmental processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","TMX2","ENSG00000213593","","","",1269.6,1385.3,1306.8,1353.1,1503.5,1405.1,0.9296055564680761,-0.1053094027961893,0.1472948324427847,0.8318124892805905,0.32570887898987905,0.4871704021850523,3531]
["High","Q9Y324","rRNA-processing protein FCF1 homolog [OS=Homo sapiens]",10,2,3,2,198,23.4,9.7,7.51,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","FCF1","ENSG00000119616","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",142.4,134.5,120.6,112.3,112.1,111.1,1.1847988077496274,0.2446420939715342,0.03173912781270338,1.4984050117757062,0.12695651125081353,0.8963450204477438,1952]
["High","Q9Y333","U6 snRNA-associated Sm-like protein LSm2 [OS=Homo sapiens]",67,5,22,5,95,10.8,6.52,32.21,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM2","ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",757.3,893,696.2,605.4,915.7,753.1,1.0317913991733356,0.04515132560817394,0.8325723526646815,0.07957801488153342,0.9108483858211901,0.040553906979826686,7137]
["High","Q9Y365","START domain-containing protein 10 [OS=Homo sapiens]",4,1,1,1,291,33,7.12,3.13,"transport","other membranes;cytosol;cytoskeleton;other cell component","other molecular function","STARD10","ENSG00000214530","","Synthesis of PC","",13.1,10,11.7,15.4,14.9,14.1,0.7837837837837838,-0.3514723705013777,0.030246563935020725,1.519323954856759,0.12384120147070887,0.9071348432441293,1907]
["High","Q9Y366","Intraflagellar transport protein 52 homolog [OS=Homo sapiens]",9,2,4,2,437,49.7,5.26,10.33,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","IFT52","ENSG00000101052","Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",31.9,31.7,35.8,38.8,39.6,38.4,0.8510273972602739,-0.23272251731773125,0.0136779324898528,1.8639795441442053,0.07699877208418937,1.1135162005588548,1387]
["High","Q9Y371","Endophilin-B1 [OS=Homo sapiens]",36,11,39,10,365,40.8,6.04,80.37,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GLB1","ENSG00000097033","Nanoparticle triggered autophagic cell death","","Autophagy; Endocytosis",1808,1805.2,1812,2033.9,1987.2,2004.3,0.9003883559597701,-0.15138069525624243,1.3098588546397086E-4,3.8827754997287056,0.01012611676933351,1.994557068852713,101]
["High","Q9Y375","Complex I intermediate-associated protein 30, mitochondrial [OS=Homo sapiens]",33,9,17,9,327,37.7,7.64,48.38,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion","other molecular function","NDUFAF1","ENSG00000137806","Mitochondrial immune response to SARS-CoV-2","Complex I biogenesis","Thermogenesis",723.7,663.9,712.7,641,628.4,629.4,1.1061196545186434,0.14550745758299471,0.023383192135954786,1.6310962017969446,0.10553523942054045,0.9766025002671046,1730]
["High","Q9Y376","Calcium-binding protein 39 [OS=Homo sapiens]",36,13,28,12,341,39.8,6.89,47.44,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CAB39","ENSG00000135932","AMP-activated protein kinase (AMPK) signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias","Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK","mTOR signaling pathway; AMPK signaling pathway",1644.2,1666.4,1635.3,1482.3,1566.7,1514.2,1.0838665848527351,0.11618718361332445,0.008320355537480425,2.0798581154560543,0.05863297476231693,1.23185807118983,1108]
["High","Q9Y383","Putative RNA-binding protein Luc7-like 2 [OS=Homo sapiens]",41,19,111,13,392,46.5,10.01,244.56,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","LUC7L2","ENSG00000146963","","","",5008.8,4574.7,5029.8,5251.5,4803.1,5112.2,0.9635058153334916,-0.053634720813204854,0.4060908292846489,0.3913768180353097,0.6037237614346037,0.21916173079411602,5252]
["High","Q9Y388","RNA-binding motif protein, X-linked 2 [OS=Homo sapiens]",10,4,10,4,322,37.3,9.83,19.58,"RNA metabolism OR transcription;other metabolic processes","nucleus","","RBMX2","ENSG00000134597","","","",418.8,483.4,470.2,593.6,600.6,585.1,0.7713145619063677,-0.3746087466138656,2.5652507471663386E-3,2.590870177223411,0.031296059115429334,1.5045103465486624,640]
["High","Q9Y394","Dehydrogenase/reductase SDR family member 7 [OS=Homo sapiens]",9,2,3,2,339,38.3,8.32,2.66,"","","other molecular function","DHRS7","ENSG00000100612","","","",114.8,125.7,124.7,117.6,101.1,133.2,1.037794828076158,0.05352125123455733,0.677443348772091,0.16912701682901332,0.816025558039569,0.08829623886656911,6482]
["High","Q9Y399","28S ribosomal protein S2, mitochondrial [OS=Homo sapiens]",18,6,9,6,296,33.2,9.26,9.57,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS2","ENSG00000122140","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",346.5,361.5,331.5,353,377.8,342,0.9689597315436242,-0.04549138415874156,0.4626002357638514,0.3347941502274971,0.6533977280832401,0.18482237993500372,5528]
["High","Q9Y3A3","MOB-like protein phocein [OS=Homo sapiens]",46,7,35,7,225,26,5.78,49.95,"","other membranes;ER/Golgi;other cell component","other molecular function","MOB4","ENSG00000115540","","","",821.9,860.1,838.3,772.4,925.9,797.8,1.0096951243940548,0.013919739588032823,0.8766606215242739,0.057168500961123525,0.9339563559641876,0.029673417995587294,7329]
["High","Q9Y3A4","Ribosomal RNA-processing protein 7 homolog A [OS=Homo sapiens]",29,7,16,7,280,32.3,9.58,27.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","","RRP7A","ENSG00000189306","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",822.8,836.6,737.2,866.3,783.4,707.9,1.0165422463522227,0.023670173211521026,0.8257142354529186,0.08317022802930658,0.9067759142639084,0.04250002410043747,7110]
["High","Q9Y3A5","Ribosome maturation protein SBDS [OS=Homo sapiens]",61,20,70,20,250,28.7,8.75,104.87,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity","SBDS","ENSG00000126524","","","Ribosome biogenesis in eukaryotes",4210.5,4359.8,3884.5,3269.7,3450.3,3262.6,1.2476509125879027,0.3192143307322132,0.005770189824377363,2.2388098994398358,0.0475249389754625,1.3230784321192666,948]
["High","Q9Y3A6-1","Transmembrane emp24 domain-containing protein 5 [OS=Homo sapiens]",12,3,5,3,229,26,4.84,9.42,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED5","ENSG00000117500","","WNT ligand biogenesis and trafficking","",219.8,230.6,231.2,200.8,214,228.5,1.0595367635628787,0.08343364687919941,0.22111838579147564,0.6553751447310658,0.41572173278589974,0.3811972711823086,4153]
["High","Q9Y3B2","Exosome complex component csl4 [OS=Homo sapiens]",24,3,8,3,195,21.4,8.24,24.08,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EXOSC1","ENSG00000171311","","Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","RNA degradation",274.5,289.6,285.6,226.1,336.5,297.7,0.9876787167267234,-0.017886272880445583,0.919031408876569,0.03666964588409409,0.9572835166099588,0.018959419105180498,7496]
["High","Q9Y3B3-1","Transmembrane emp24 domain-containing protein 7 [OS=Homo sapiens]",25,5,15,5,224,25.2,6.89,25.06,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED7","ENSG00000134970; ENSPTRG00000017152","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",836.5,937.5,742.6,587.8,822.7,773.1,1.1525004579593332,0.20476732392622082,0.28943762788254307,0.538445009777184,0.49022321008826386,0.30960613050819674,4610]
["High","Q9Y3B4","Splicing factor 3B subunit 6 [OS=Homo sapiens]",34,4,4,4,125,14.6,9.38,8.97,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","SF3B6","ENSG00000115128","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",210.7,228.5,184.1,302.4,227.9,210.3,0.8416149068322981,-0.2487678367607455,0.27622522136896793,0.5587366697063865,0.47621252560143557,0.3221991857307083,4529]
["High","Q9Y3B6","ER membrane protein complex subunit 9 [OS=Homo sapiens]",8,1,1,1,208,23,5.91,3.52,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC9","ENSG00000100908; ENSG00000285377","","","",18.6,29.5,18,24.6,17.1,18.3,1.1016666666666666,0.13968777101181068,0.6681511994215868,0.1751252476381438,0.8093274224455088,0.09187574415582411,6446]
["High","Q9Y3B7-1","39S ribosomal protein L11, mitochondrial [OS=Homo sapiens]",43,9,19,9,192,20.7,9.91,33.13,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL11","ENSG00000174547; ENSPPAG00000028194; ENSPTRG00000003924","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",983.1,928.2,961.8,899.6,984.1,988.8,1.0002088772845954,3.0131475483164474E-4,0.9954676987589921,0.001972827528407289,0.9984087080167259,6.9163977391094886E-4,7785]
["High","Q9Y3B8-1","Oligoribonuclease, mitochondrial [OS=Homo sapiens]",34,6,27,6,237,26.8,6.87,49.9,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","REXO2","ENSG00000076043; ENSPPAG00000039849; ENSPTRG00000004306","","","Ribosome biogenesis in eukaryotes",1086.1,1076.1,1031.5,1286.3,1023.5,1028.2,0.9567705212702216,-0.06375515505078706,0.6154033398269011,0.21084015114274013,0.7728919538955193,0.11188121385226055,6217]
["High","Q9Y3B9","RRP15-like protein [OS=Homo sapiens]",18,5,23,5,282,31.5,5.52,39.06,"RNA metabolism OR transcription;other metabolic processes","other cell component","","RRP15","ENSG00000067533","","","",994.4,907.4,996.1,1208.6,1025.6,1004.2,0.8948554841897235,-0.16027338354652199,0.18597723973046296,0.7305402023643104,0.3755133922460447,0.4253745697787405,3867]
["High","Q9Y3C0","WASH complex subunit 3 [OS=Homo sapiens]",17,2,2,2,194,21.2,4.46,0,"cell organization and biogenesis;transport","other cytoplasmic organelle;other cell component","","WASHC3","ENSG00000120860","","","Endocytosis",21,21,24,24,18.1,23.1,1.0122699386503067,0.017594060014738132,0.904625899400766,0.04353098257968526,0.950392764063668,0.022096878906635215,7432]
["High","Q9Y3C1","nucleolar protein 16 [OS=Homo sapiens]",17,3,6,3,178,21.2,9.94,8.83,"other biological processes","nucleus;other cell component","","NOP16","ENSG00000048162","","","",296.7,297.9,263.3,410.1,273.7,258.7,0.9102387267904508,-0.13568312673113853,0.5991998977881532,0.22242826939077426,0.7591356160846828,0.11968063246281421,6163]
["High","Q9Y3C4","EKC/KEOPS complex subunit TPRKB [OS=Homo sapiens]",14,2,9,2,175,19.6,6.79,12.12,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","TPRKB","ENSG00000144034","","tRNA modification in the nucleus and cytosol","",230.3,246.2,208.7,229,231.6,235.3,0.9846242276189107,-0.02235485598934721,0.7624065368488868,0.11781338872698321,0.8685249839095577,0.061217684162195925,6854]
["High","Q9Y3C5","Ring finger protein 11 [OS=Homo sapiens]",8,1,2,1,154,17.4,4.78,3.26,"protein metabolism;other metabolic processes","nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","RNF11","ENSG00000123091","","","",54.7,62,60.6,56.6,52.1,50.1,1.1164987405541562,0.15898162375573088,0.10471670568564313,0.9799840288431969,0.262396674580713,0.5810416731850883,3116]
["High","Q9Y3C6","Peptidyl-prolyl cis-trans isomerase-like 1 [OS=Homo sapiens]",40,6,42,6,166,18.2,7.99,66.58,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","PPIL1","ENSG00000137168","","mRNA Splicing - Major Pathway","Spliceosome",2168.5,2207.2,2167.5,2439.8,2294.7,2322.2,0.9272322757096093,-0.10899730939309639,0.02100455556450119,1.6776865032679409,0.09832348312207752,1.0073427449110253,1668]
["High","Q9Y3C8","ubiquitin-fold modifier-conjugating enzyme 1 [OS=Homo sapiens]",26,5,12,5,167,19.4,7.4,25.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes","","other molecular function","UFC1","ENSG00000143222","","","",557.3,546.3,481,535.4,529.7,482,1.0242388985844484,0.03455225596787578,0.6908075911256574,0.16064289871623116,0.8241139299479194,0.08401274494437039,6545]
["High","Q9Y3D0","Mitotic spindle-associated MMXD complex subunit MIP18 [OS=Homo sapiens]",26,2,2,2,163,17.7,5.19,7.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CIAO2B","ENSG00000166595","","Cytosolic iron-sulfur cluster assembly","",50.9,61.1,52.7,62.7,38.3,34.6,1.2146017699115046,0.28048337659001116,0.3585233457186988,0.445482559419625,0.5602061803825495,0.2516521042035765,4997]
["High","Q9Y3D2","Methionine-R-sulfoxide reductase B2, mitochondrial [OS=Homo sapiens]",21,2,3,2,182,19.5,8.63,5.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","MSRB2","ENSG00000148450","Sulindac metabolic pathway; Methionine de novo and salvage pathway","Protein repair","",40,35.2,38.3,31.4,25.4,36.3,1.2191192266380237,0.28583922461948374,0.12010267854913383,0.9204473067841347,0.2862520494846267,0.5432513952138801,3276]
["High","Q9Y3D3","28S ribosomal protein S16, mitochondrial [OS=Homo sapiens]",23,2,4,2,137,15.3,9.5,7.77,"protein metabolism;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","other molecular function","MRPS16","ENSG00000182180","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",87.9,82.6,84.7,93.9,83.2,79.8,0.9933826391592058,-0.009578561135947712,0.9062614306080996,0.042746502662367306,0.9508316649003012,0.021896363689247158,7442]
["High","Q9Y3D6","mitochondrial fission 1 protein [OS=Homo sapiens]",12,2,9,2,152,16.9,8.79,17.75,"cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FIS1","ENSG00000214253","CAMKK2 pathway","Class I peroxisomal membrane protein import","Mitophagy",356,364.4,336.9,266,300.8,312.1,1.2029809989759928,0.26661385539878,0.02087863139329998,1.6802979729982341,0.09814590844002785,1.008127800790993,1661]
["High","Q9Y3D8","Adenylate kinase isoenzyme 6 [OS=Homo sapiens]",56,5,10,5,172,20,4.58,15.84,"other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AK6","ENSG00000085231; ENSG00000279247","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Metabolic pathways; Biosynthesis of cofactors; Ribosome biogenesis in eukaryotes",284.8,274.6,260.4,268.6,292.7,259.7,0.9985383678440927,-2.1102320303882996E-3,0.9752809746933346,0.010870247706995686,0.9869095192334834,0.005722662020207142,7716]
["High","Q9Y3D9","28S ribosomal protein S23, mitochondrial [OS=Homo sapiens]",11,2,3,2,190,21.8,8.9,7.9,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS23","ENSG00000181610","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",190.4,179.5,183.7,243,214.6,198,0.8444173276388041,-0.24397191146273434,0.06567318642910269,1.1826119114571307,0.19836605015026454,0.7025326542284566,2585]
["High","Q9Y3E0","vesicle transport protein GOT1B [OS=Homo sapiens]",17,3,44,3,138,15.4,10.36,91.96,"transport","other membranes;ER/Golgi;other cell component","","GOLT1B","ENSG00000111711","","","",2334.4,2465.9,2423.9,2581.7,2585.7,2482.8,0.9443151813024497,-0.08265963084061932,0.05055598858416489,1.2962273928917263,0.17007374358688473,0.7693627286890087,2321]
["High","Q9Y3E1","Hepatoma-derived growth factor-related protein 3 [OS=Homo sapiens]",30,5,21,4,203,22.6,7.99,36.17,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","HDGFL3","ENSG00000166503","","","",631.6,674.2,663.4,706.2,749.3,733.1,0.8997532669286303,-0.1523986594231863,0.0151111210014105,1.820703316821244,0.08170888696607562,1.087730705396229,1444]
["High","Q9Y3E5","Peptidyl-tRNA hydrolase 2, mitochondrial [OS=Homo sapiens]",21,2,5,2,179,19.2,8.73,12.87,"other biological processes","cytosol;mitochondrion","other molecular function","PTRH2","ENSG00000141378","Apoptosis modulation and signaling","Ub-specific processing proteases","",169.1,162.6,149.3,142.9,143.2,139,1.1314984709480123,0.17823463501822964,0.03570239352341189,1.4473026673845866,0.13718714991673228,0.8626865663378328,2032]
["High","Q9Y3E7","Charged multivesicular body protein 3 [OS=Homo sapiens]",9,2,4,2,222,25.1,5.12,5.58,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","CHMP3","ENSG00000115561","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Endocytosis; Necroptosis",86.9,73.8,72,68.2,74.9,74.1,1.0713627992633517,0.09944710760098692,0.3724216159947968,0.4289651197561718,0.5742235342984544,0.2409190121068351,5064]
["High","Q9Y3F4","Serine-threonine kinase receptor-associated protein [OS=Homo sapiens]",68,21,239,21,350,38.4,5.12,565.03,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","STRAP","ENSG00000023734","TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer","Downregulation of TGF-beta receptor signaling","",8476.8,8277.8,8918.2,8540.5,8463,8673.1,0.9998520053278083,-2.1352698046649642E-4,0.9952243621964841,2.0790013851695907E-3,0.9982928854098341,7.4202398682967035E-4,7784]
["High","Q9Y3I0","tRNA-splicing ligase RtcB homolog [OS=Homo sapiens]",56,25,115,25,505,55.2,7.23,254.71,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","RTCB","ENSG00000100220","Unfolded protein response","tRNA processing in the nucleus","",5672,5744.1,5674.6,5732.9,5701.4,5797.7,0.9918001392757662,-0.011878666942267937,0.2708065331462861,0.5673408626044837,0.47029746681632606,0.3276273605068529,4496]
["High","Q9Y3L3-1","SH3 domain-binding protein 1 [OS=Homo sapiens]",15,8,16,8,701,75.7,6.77,35.16,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SH3BP1","ENSG00000100092","","RAC1 GTPase cycle","",565.8,533.6,593.6,662.6,614.5,642.8,0.8818167612896507,-0.18144919538931523,0.027320599612016758,1.5635097733165475,0.11663162480624759,0.933183674134329,1829]
["High","Q9Y3M8-4","Isoform 4 of StAR-related lipid transfer protein 13 [OS=Homo sapiens]",3,3,3,2,1078,120.6,6.95,8.94,"","","","STARD13","","","","",111,137.6,145.8,106.2,97.6,128.3,1.1875940981632038,0.2480418288752031,0.21016485709882632,0.6774399031700117,0.4035826867259311,0.3940674728133961,4066]
["High","Q9Y3P9","Rab GTPase-activating protein 1 [OS=Homo sapiens]",26,22,38,20,1069,121.7,5.25,80,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity;other molecular function","RABGAP1","ENSG00000011454","","TBC/RABGAPs","",1375.8,1369.3,1366.7,1221.1,1181,1205,1.139918494081118,0.18893067317182255,1.4826250936840428E-4,3.828968653643466,0.010620492414206428,1.9738553469254543,109]
["High","Q9Y3Q3","Transmembrane emp24 domain-containing protein 3 [OS=Homo sapiens]",9,2,7,2,217,24.8,5.6,19.2,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED3","ENSG00000166557","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",418.7,447.4,414.3,420.9,499.5,430.6,0.947742413027387,-0.07743309266746588,0.4299502271292394,0.3665818172907774,0.6254986721492642,0.20377360791917745,5367]
["High","Q9Y3Q4","Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [OS=Homo sapiens]",2,2,2,2,1203,129,8.91,2.14,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","HCN4","ENSG00000138622","Genes targeted by miRNAs in adipocytes","HCN channels","cAMP signaling pathway; Taste transduction",44.9,43.8,47.7,43.1,39.3,44.6,1.0740157480314958,0.10301514736464391,0.18487122477847684,0.7331306815528114,0.37424799664774366,0.42684051576021775,3857]
["High","Q9Y3R0","Glutamate receptor-interacting protein 1 [OS=Homo sapiens]",4,3,4,3,1128,122.3,6.47,2.15,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","GRIP1","ENSG00000155974","Brain-derived neurotrophic factor (BDNF) signaling pathway; Fragile X syndrome; 7q11.23 copy number variation syndrome; Development of ureteric collection system","Trafficking of GluR2-containing AMPA receptors","",9.2,17.9,16.5,17.5,15.4,18,0.8565815324165029,-0.22333752129876897,0.43570732389441796,0.3608051398572255,0.6318727312346982,0.19937038641451058,5384]
["High","Q9Y3R5-1","Protein dopey-2 [OS=Homo sapiens]",3,5,5,5,2298,258.1,6.29,4.3,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","DOP1B","ENSG00000142197","","","",116.7,117.7,123.6,87.1,106.9,88,1.2695035460992907,0.3442644248654628,0.020422873225813272,1.689883158510832,0.09693726087972646,1.0135092561381898,1645]
["High","Q9Y3S1-1","Serine/threonine-protein kinase WNK2 [OS=Homo sapiens]",12,25,42,17,2297,242.5,6.13,74.88,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","WNK2","ENSG00000165238","","Stimuli-sensing channels","",1737.2,1705.2,1719.3,1733.5,1775,1722.4,0.98677091896232,-0.01921289615960777,0.28030943030657063,0.5523622912471573,0.4815524822516399,0.31735637414650825,4545]
["High","Q9Y3S2","zinc finger protein 330 [OS=Homo sapiens]",24,7,19,7,320,36.2,6.16,30.55,"","nucleus;other cell component","other molecular function","ZNF330","ENSG00000109445","","","",705.8,636,685.8,686,648.6,631.6,{"$f":"AVERAGE(T7618:V7618)/AVERAGE(W7618:Y7618)","v":1.0312277489573798},{"$f":"LOG(Z7618,2)","v":0.04436299032556058},{"$f":"TTEST(T7618:V7618,W7618:Y7618,2,2)","v":0.4790686375846613},{"$f":"-LOG10(AB7618)","v":0.3196022594690254},{"$f":"AB7618*7808/AF7618","v":0.6677200860872965},{"$f":"-LOG10(AD7618)","v":0.17540555929793938},5602]
["High","Q9Y3T6","R3H and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",10,4,5,4,440,49.1,5.63,11.19,"","","nucleic acid binding activity","R3HCC1","ENSG00000104679","","","",167.3,179.6,184.5,195.5,242.6,179.7,0.8601489155066365,-0.21734164313713097,0.2151402129848797,0.6672784057670581,0.40931159429481984,0.38794595321218267,4104]
["High","Q9Y3T9","Nucleolar complex protein 2 homolog [OS=Homo sapiens]",27,18,61,18,749,84.9,5.62,100.48,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","other molecular function","NOC2L","ENSG00000188976","","Regulation of TP53 Activity through Phosphorylation","",2604.9,2778.2,2473.3,2497.6,2806.9,2703.2,0.9811056857774394,-0.0275195413842699,0.7109474179307701,0.1481625187455899,0.837772025234448,0.07687414563289567,6626]
["High","Q9Y3U8","60S ribosomal protein L36 [OS=Homo sapiens]",21,2,9,2,105,12.2,11.59,23.05,"protein metabolism;other metabolic processes","cytosol;translational apparatus;nucleus","other molecular function","RPL36","ENSG00000130255","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",511.7,554.9,479.8,454.2,397.3,369.8,1.2661917628756243,0.3404959153500692,0.030484404641707343,1.515922282300125,0.12390537815848565,0.9069098425031833,1921]
["High","Q9Y3X0","coiled-coil domain-containing protein 9 [OS=Homo sapiens]",11,5,7,5,531,59.7,5.4,15.69,"","","","CCDC9","ENSG00000105321","IL-18 signaling pathway","","",297.7,224.8,253.4,375.9,273.4,202.5,0.9108945761915942,-0.13464400376528451,0.6672877425418531,0.17568685266358142,0.8087834048070148,0.09216776848861855,6442]
["High","Q9Y3Z3","deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [OS=Homo sapiens]",40,24,80,24,626,72.2,7.14,136.63,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMHD1","ENSG00000101347","","Interferon alpha/beta signaling; Nucleotide catabolism","Human immunodeficiency virus 1 infection",3000.1,2838.3,2975.2,2893.3,2852.4,2808.5,1.0303242851464776,0.04309848395221334,0.19708648924217156,0.7053431466423599,0.388696970952987,0.41038884373592904,3959]
["High","Q9Y426","C2 domain-containing protein 2 [OS=Homo sapiens]",10,4,6,4,696,75.5,6.92,13.35,"","other membranes","","C2CD2","ENSG00000157617","","","",115.2,120.1,121.4,135.8,158.7,137.3,0.8260768874478926,-0.2756520275556931,0.030513085440096597,1.5155138748925985,0.12389296469905056,0.9069533544724429,1923]
["Low","Q9Y448","Small kinetochore-associated protein [OS=Homo sapiens]",2,1,1,1,316,35.4,6.3,1.83,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KNSTRN","ENSG00000128944","Leukocyte-intrinsic Hippo pathway functions","","",78.8,74.9,74.1,120.7,78.4,68.1,0.8525449101796405,-0.23015226076594072,0.46196363919865047,0.33539220608202974,0.6530892802576612,0.18502744464707144,5523]
["High","Q9Y450-1","HBS1-like protein [OS=Homo sapiens]",28,15,37,15,684,75.4,6.61,87.73,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol","nucleic acid binding activity;other molecular function","HBS1L","ENSG00000112339","","mRNA decay by 3' to 5' exoribonuclease","mRNA surveillance pathway; Legionellosis",1361.8,1338.4,1387.8,1412.7,1355.3,1368.1,0.9883706873624912,-0.016875870363784917,0.5154423587006483,0.2878198942949319,0.6979836865651511,0.15615472768848548,5766]
["Medium","Q9Y458-1","T-box transcription factor TBX22 [OS=Homo sapiens]",2,1,2,1,520,57.9,7.33,2.14,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TBX22","ENSG00000122145; ENSG00000277800","","","",48.2,68.1,44.6,71.9,45.8,53.6,0.9392877991827203,-0.09036082536055277,0.7609186106349707,0.11866179374511775,0.8675894439015553,0.061685740755579165,6848]
["High","Q9Y462","Zinc finger protein 711 [OS=Homo sapiens]",4,2,2,2,761,86.2,6.87,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF711","ENSG00000147180","","Generic Transcription Pathway","",31.4,40.3,42,41.9,37.1,41.2,0.9459234608985024,-0.08020464181893765,0.5809012508409286,0.23589768836672503,0.74575418720256,0.12740429951620302,6082]
["High","Q9Y467","sal-like protein 2 [OS=Homo sapiens]",24,14,35,13,1007,105.2,6.3,102.72,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SALL2","ENSG00000165821","","","",1371.5,1307.6,1418.4,1683.9,1577.8,1593,0.8440274373287742,-0.2446381966009153,0.005430706950665603,2.2651436317760756,0.04559458050623336,1.3410867756713754,930]
["High","Q9Y467-3","Isoform 2 of Sal-like protein 2 [OS=Homo sapiens]",13,1,3,1,198,20.9,4.77,9.61,"","","","SALL2","","","","",58.3,69.3,62.4,87,60.7,70,0.8727606798346349,-0.19634198896989632,0.3304400037745983,0.48090738154872176,0.532193801458759,0.2739301880483161,4848]
["High","Q9Y478","5'-AMP-activated protein kinase subunit beta-1 [OS=Homo sapiens]",11,2,2,2,270,30.4,6.4,5.7,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","PRKAB1","ENSG00000111725","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma","Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy",112.8,124.3,105.7,126,117.5,125.9,0.9279913373037358,-0.10781675686993825,0.22020577801804783,0.6571712896856456,0.41460494689291477,0.3823655203910281,4147]
["High","Q9Y483","Metal-response element-binding transcription factor 2 [OS=Homo sapiens]",9,4,4,4,593,67.1,8.72,8.81,"","","","","","","","",158.3,171.7,166.9,213,210.3,221.6,0.7705070553574197,-0.3761199276572838,6.8548557611983348E-4,3.1640016791348167,0.01814329280794461,1.7412838904543444,295]
["High","Q9Y484-1","WD repeat domain phosphoinositide-interacting protein 4 [OS=Homo sapiens]",3,1,1,1,360,39.8,7.14,2.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;other cell component","other molecular function","WDR45","ENSCANG00000035794; ENSCSAG00000012964; ENSG00000196998; ENSGGOG00000000589; ENSMFAG00000032970; ENSMLEG00000042347; ENSMMUG00000010620","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway","Macroautophagy","",80.9,78.8,86.3,94.7,82.7,91.3,0.9155191663565315,-0.12733800578656373,0.14684445845207666,0.8331424380352532,0.32489700526886217,0.488254291736587,3529]
["High","Q9Y485","DmX-like protein 1 [OS=Homo sapiens]",5,10,10,9,3027,337.6,6.34,18.22,"other biological processes","other cell component","","DMXL1","ENSG00000172869","","","Lysosome",346.4,361.6,337.6,364.7,410.9,380.2,0.9046547845648035,-0.1445607287801696,0.07401157906650548,1.1307003298460787,0.21324074145803495,0.671129816061849,2710]
["High","Q9Y487","V-type proton ATPase 116 kDa subunit a isoform 2 [OS=Homo sapiens]",20,13,19,12,856,98,6.61,26.08,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V0A2","ENSG00000185344","","Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; ROS and RNS production in phagocytes","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Human papillomavirus infection; Rheumatoid arthritis",522.7,577,529.6,519.2,554.5,495.3,1.038432122370937,0.05440691678989714,0.45337269177921263,0.3435446424952761,0.6457376828551792,0.1899438690401203,5482]
["High","Q9Y490","Talin-1 [OS=Homo sapiens]",61,118,456,100,2541,269.6,6.07,1103.31,"cell adhesion;cell organization and biogenesis;signal transduction","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN1","ENSG00000137076","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion","Signaling by BRAF and RAF1 fusions; p130Cas linkage to MAPK signaling for integrins; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Platelet degranulation ; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection",17849,17736.8,18059.9,18608.7,18607.5,18838.2,0.9570292430210654,-0.06336508645933796,2.7492156128491258E-3,2.560791198389135,0.032134544169350264,1.493027856206045,668]
["High","Q9Y496","kinesin-like protein KIF3A [OS=Homo sapiens]",11,7,8,7,699,80,6.54,14.44,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3A","ENSG00000131437","Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO","Hedgehog signaling pathway",310.8,353.2,334.1,346.4,326.4,315.2,1.0102226720647773,0.014673325131982317,0.8364345377306799,0.07756804276473189,0.9132821801987343,0.039395016146966055,7151]
["High","Q9Y4A5","Transformation/transcription domain-associated protein [OS=Homo sapiens]",15,43,73,43,3859,437.3,8.19,147.48,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus","other molecular function","TRRAP","ENSG00000196367","Rett syndrome causing genes","Ub-specific processing proteases; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex","Human T-cell leukemia virus 1 infection",2431.4,2482.1,2347.8,2393.3,2543,2515,0.9745010937688725,-0.037264290138889024,0.35333826967465953,0.45180932206576924,0.5553271355917354,0.2554511045756576,4968]
["High","Q9Y4A8","nuclear factor erythroid 2-related factor 3 [OS=Homo sapiens]",2,1,1,1,694,76.1,5.44,3.21,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFE2L3","ENSG00000050344","","","",26.7,31.7,19.6,41.2,41,44.2,0.6170886075949367,-0.6964504344274923,0.011616813974215425,1.9349129651593833,0.0711962978890691,1.1475425885000794,1274]
["High","Q9Y4B4","Helicase ARIP4 [OS=Homo sapiens]",11,12,19,12,1467,162.7,6.09,39.73,"cell organization and biogenesis","nucleus","nucleic acid binding activity;other molecular function","RAD54L2","ENSG00000164080","","","",748.4,749.8,808.5,869.2,745.7,782,0.9623680587425424,-0.05533933501931436,0.5103616669785628,0.2921219527133716,0.6936299209344853,0.1588721810790402,5745]
["High","Q9Y4B5","Microtubule cross-linking factor 1 [OS=Homo sapiens]",4,6,8,3,1905,209.4,6.43,15.27,"cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MTCL1","ENSG00000168502","","","",67.9,64,63.1,73.5,69.3,67.8,0.9259259259259259,-0.11103131238874385,0.08229165596412269,1.084644198231834,0.22688320966379588,0.6441976425909299,2832]
["High","Q9Y4B6","DDB1- and CUL4-associated factor 1 [OS=Homo sapiens]",14,17,28,17,1507,168.9,5.06,41.4,"protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","DCAF1","ENSG00000145041","Hippo-Merlin signaling dysregulation","Antigen processing: Ubiquitination & Proteasome degradation","Human immunodeficiency virus 1 infection",804.7,805.6,839.9,900.9,898,923.8,0.899915525030301,-0.1521385127114085,0.003043788331589209,2.516585552170538,0.03356765436871263,1.4740790052016715,708]
["High","Q9Y4C1","Lysine-specific demethylase 3A [OS=Homo sapiens]",18,18,28,17,1321,147.2,8.07,66.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3A","ENSG00000115548","Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; HDMs demethylate histones","Thermogenesis",734.8,757.8,775.8,598.2,525.1,631.9,1.292388331814038,0.37003963056115285,7.0856508406075495E-3,2.1496202521910317,0.05329938512857779,1.2732778010448353,1038]
["High","Q9Y4C2-1","TRPM8 channel-associated factor 1 [OS=Homo sapiens]",17,10,38,10,921,102.1,6.54,88.55,"other biological processes","plasma membrane;other membranes","other molecular function","TCAF1","ENSG00000198420","","","",1297,1399.6,1358.2,637.2,642.7,658.5,2.0918283120099055,1.0647644464336117,2.0643092143441517E-5,4.685225248893089,0.005756473694856835,2.239843475576673,28]
["Medium","Q9Y4C4","Malignant fibrous histiocytoma-amplified sequence 1 [OS=Homo sapiens]",1,1,1,1,1052,116.9,7.88,0,"stress response;developmental processes;other biological processes","other cell component","other molecular function","MFHAS1","ENSG00000147324","","","",24.1,20.6,22,15.7,25.4,19.6,1.098846787479407,0.13599024492890302,0.5409470760679352,0.26684522231667535,0.716734221947809,0.14464185875318913,5893]
["High","Q9Y4C5-1","Carbohydrate sulfotransferase 2 [OS=Homo sapiens]",4,2,2,2,530,57.8,9.98,2.4,"other metabolic processes;stress response;developmental processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","CHST2; HEL-S-75","ENSG00000175040; ENSPTRG00000043559","Metapathway biotransformation Phase I and II","Keratan sulfate biosynthesis","Glycosaminoglycan biosynthesis",137.4,134,132.6,136.4,128.2,139.9,0.9987639060568602,-1.7844096781830631E-3,0.9666682042668563,0.014722566023382238,0.9834195881323274,0.007261145513970979,7675]
["High","Q9Y4C8","Probable RNA-binding protein 19 [OS=Homo sapiens]",28,23,42,23,960,107.3,6.54,86.59,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","RBM19","ENSG00000122965","","","",2278,2172.2,2171.2,2064.6,2186.4,2178.4,1.0298628176812767,0.04245217679516209,0.293278802913576,0.5327193250533306,0.4942630893911507,0.30604182059785046,4633]
["High","Q9Y4D1","Disheveled-associated activator of morphogenesis 1 [OS=Homo sapiens]",9,10,10,10,1078,123.4,7.23,14.3,"cell-cell signaling;cell organization and biogenesis;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","DAAM1","ENSG00000100592","Physico-chemical features and toxicity-associated pathways; Wnt signaling","RHO GTPases Activate Formins; RHOA GTPase cycle; PCP/CE pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle","Wnt signaling pathway",428.5,421.9,426.7,327.9,312.6,333.4,1.311325598110689,0.3910259467781571,1.0152699132616734E-4,3.9934184836061117,0.00911175572729557,2.040397931566095,87]
["High","Q9Y4D8-1","Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",3,8,10,7,3996,439.1,6.19,14.21,"protein metabolism;other metabolic processes;other biological processes","other membranes","other molecular function","HECTD4","","","","",137.6,138.5,142.8,118.8,132,135.7,1.0838292367399742,0.1161374700543137,0.11485204630887513,0.9398612626131803,0.2779804022255725,0.5559858210074876,3226]
["High","Q9Y4E1","WASH complex subunit 2C [OS=Homo sapiens]",28,24,45,6,1318,144.6,4.79,72.31,"","","","","","","","",87.9,78.5,91.1,125.7,105.3,112.2,0.7502913752913754,-0.4144771205416024,0.01570271821353226,1.8040251626890889,0.08346277999405029,1.07850715382071,1469]
["High","Q9Y4E5","E3 SUMO-protein ligase ZNF451 [OS=Homo sapiens]",14,13,18,13,1061,121.4,6.77,38.79,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","ZNF451","ENSG00000112200","","","",782.3,787.9,793.3,740.6,751.9,750.1,1.0539106394363686,0.07575254675939613,1.0410761073501047E-3,2.982517520447205,0.021447815953006908,1.6686169257566417,379]
["High","Q9Y4E8","ubiquitin carboxyl-terminal hydrolase 15 [OS=Homo sapiens]",31,25,59,23,981,112.3,5.22,110.07,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","USP15","ENSG00000135655","","Ub-specific processing proteases; UCH proteinases; Downregulation of TGF-beta receptor signaling","Mitophagy",2436.8,2323.2,2368.5,2225,2109.2,2134.7,1.1019647853576342,0.14007812154822555,0.010334218505651683,1.985722360015483,0.0666856017290317,1.1759679256732976,1210]
["High","Q9Y4F1","FERM, RhoGEF and pleckstrin domain-containing protein 1 [OS=Homo sapiens]",13,10,15,10,1045,118.6,8.15,31.63,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","FARP1","ENSG00000152767","","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOA GTPase cycle; RHOF GTPase cycle","",650.8,667.7,710.3,667.1,706.6,707.8,0.9746817199135238,-0.03699690788817346,0.4727641523058685,0.325355461581074,0.6625996232640856,0.17874881538188145,5571]
["High","Q9Y4F5","Centrosomal protein of 170 kDa protein B [OS=Homo sapiens]",8,11,13,9,1589,171.6,6.84,26.46,"","cytoskeleton;other cell component","","CEP170B","ENSG00000099814","","","",426.4,364.2,439.1,407.6,340.8,384.2,1.0857319441991875,0.11866796086835295,0.3457089823907821,0.46128933624564183,0.5479690894249344,0.2612439390900908,4926]
["High","Q9Y4G6","Talin-2 [OS=Homo sapiens]",34,72,166,53,2542,271.4,5.57,360.2,"cell adhesion;cell organization and biogenesis","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN2","ENSG00000171914","Focal adhesion","","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection",3854,3873.4,4011.9,3531,3380.1,3381.7,1.1405351313539562,0.1897108859744954,2.3957586949307674E-3,2.620556926991215,0.030716065500852926,1.512634414965455,609]
["High","Q9Y4G8","rap guanine nucleotide exchange factor 2 [OS=Homo sapiens]",4,4,6,3,1499,167.3,6.67,7.87,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RAPGEF2","ENSG00000109756","MAPK signaling pathway","RAF/MAP kinase cascade","MAPK signaling pathway; Rap1 signaling pathway; Tight junction",28.2,32.8,25.2,27,26.6,31.8,1.009367681498829,0.013451799468607766,0.9279493225005763,0.03247574097868749,0.9627196797880015,0.016500150303897607,7526]
["High","Q9Y4H2","Insulin receptor substrate 2 [OS=Homo sapiens]",6,7,8,7,1338,137.2,8.65,17,"other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","IRS2","ENSG00000185950","Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Nonalcoholic fatty liver disease; Insulin signaling; FOXA2 pathway; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways","PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF/MAP kinase cascade; Growth hormone receptor signaling; Interleukin-7 signaling; Signaling by Leptin; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); PI3K Cascade; PI3K/AKT activation; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; SOS-mediated signalling; IRS activation; Signal attenuation","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Alzheimer disease; MicroRNAs in cancer",390,424.5,466.5,369.9,342.7,333.3,1.224782483985085,0.29252555564420485,0.03373468034270253,1.4719234007023465,0.13163437487047544,0.8806306846799226,2001]
["High","Q9Y4I1-1","Unconventional myosin-Va [OS=Homo sapiens]",10,15,19,11,1855,215.3,8.48,27.22,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5A","ENSG00000197535","Joubert syndrome","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing","Pathogenic Escherichia coli infection",774.1,782,769.2,763.3,789.8,742.2,1.0130701869036727,0.018734129509362523,0.5219645524216925,0.28235898973793866,0.7026722802256163,0.15324717864224052,5800]
["High","Q9Y4I5","Tesmin [OS=Homo sapiens]",10,3,3,3,508,55,5.71,5.92,"other biological processes","nucleus;other cell component","other molecular function","TESMIN","ENSG00000132749","","","",46,48.1,50.6,72,52.6,59.8,0.7847071583514099,-0.3497737338976135,0.08522341939945251,1.0694410446894078,0.23209782304531748,0.6343289329772569,2867]
["High","Q9Y4K0","Lysyl oxidase homolog 2 [OS=Homo sapiens]",8,5,7,5,774,86.7,6.38,16.64,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","LOXL2","ENSG00000134013","Canonical and non-canonical TGF-B signaling","Crosslinking of collagen fibrils; Elastic fibre formation","",268.9,275.9,283.6,255.5,238.1,227.5,1.1488004437664678,0.20012821156778615,0.017725027983629175,1.7514130704960302,0.08957735824995249,1.0478017495982483,1545]
["High","Q9Y4K3","TNF receptor-associated factor 6 [OS=Homo sapiens]",19,6,9,6,522,59.5,6.44,15.13,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TRAF6","ENSG00000175104","IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; T-cell receptor (TCR) signaling pathway; Toll-like receptor signaling pathway","Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; TRAF6 mediated NF-kB activation; Ovarian tumor domain proteases; TRAF6 mediated IRF7 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PIP3 activates AKT signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","MAPK signaling pathway; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; Autophagy; Endocytosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; Neurotrophin signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",99.7,105.7,121.1,109.7,98,103.3,1.0498392282958198,0.07016841141582801,0.5135215265094676,0.2894413463250774,0.6963487459162769,0.15717320220850522,5758]
["High","Q9Y4K4","mitogen-activated protein kinase kinase kinase kinase 5 [OS=Homo sapiens]",12,7,15,7,846,95,7.64,13.31,"","","","","","","","",352.5,349.3,392.9,404.2,376.7,426.2,0.9068842680805235,-0.14100964172949843,0.134995929245531,0.8696793273039427,0.3070341437661247,0.5128133260710575,3433]
["High","Q9Y4L1","Hypoxia up-regulated protein 1 [OS=Homo sapiens]",61,48,364,48,999,111.3,5.22,807.97,"stress response;transport;other biological processes","non-structural extracellular;ER/Golgi;other cell component","other molecular function","HYOU1","ENSG00000149428; ENSG00000280682","VEGFA-VEGFR2 signaling pathway","XBP1(S) activates chaperone genes; Scavenging by Class F Receptors","Protein processing in endoplasmic reticulum",13286.4,12857.3,13153.8,13883.8,12869.7,13655.9,0.9724841249808212,-0.04025339542953769,0.3272309201437265,0.48514566645135293,0.5285517220691387,0.2769125078643491,4834]
["High","Q9Y4L5","E3 ubiquitin-protein ligase RNF115 [OS=Homo sapiens]",11,2,2,2,304,33.7,5.69,6.65,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","RNF115","ENSG00000265491","","Antigen processing: Ubiquitination & Proteasome degradation","",50.9,59.2,64.8,66.8,61.9,69.2,0.8837796867104598,-0.1782413231258595,0.1689892154660532,0.7721410102563298,0.35393449419499556,0.4510771092796381,3728]
["High","Q9Y4P1-1","Cysteine protease ATG4B [OS=Homo sapiens]",27,7,28,7,393,44.3,5.07,63.67,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol","other molecular function","ATG4B","ENSG00000168397","","Macroautophagy","Autophagy; Autophagy",546.5,494.1,493.3,531.7,520.4,508.7,0.9827652485904663,-0.02508125120092703,0.6584888187604385,0.18145159502546168,0.8027292266793917,0.09543092444753139,6405]
["High","Q9Y4P3","Transducin beta-like protein 2 [OS=Homo sapiens]",25,12,21,12,447,49.8,9.44,35.73,"stress response;signal transduction","other membranes;ER/Golgi","other molecular function","TBL2","ENSG00000106638","7q11.23 copy number variation syndrome","","",842.5,913.5,875.9,924.1,965.3,907.2,0.941107058571122,-0.0875692443201868,0.10988289282353353,0.9590699156806698,0.2704809669502364,0.5678632896676006,3172]
["High","Q9Y4P8-1","WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",23,6,9,1,454,49.4,6.46,22.96,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","WIPI2","ENSG00000157954","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease","Macroautophagy","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis",401.8,429.6,344.7,308.3,393.9,358.8,1.1084825636192273,0.14858607685572314,0.3374528205921964,0.4717869374662664,0.5388203728392371,0.26855599193125124,4890]
["High","Q9Y4P8-6","Isoform 6 of WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",24,6,9,1,443,48.2,6.3,21.67,"","","","WIPI2","","","","",23.7,22.7,22.4,23.6,25,23.5,0.954230235783634,-0.06759069453872435,0.15251676791597288,0.8166824067233803,0.33394585639032986,0.47632394090408076,3566]
["High","Q9Y4R8","telomere length regulation protein TEL2 homolog [OS=Homo sapiens]",23,15,27,15,837,91.7,5.76,55.26,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TELO2","ENSG00000100726","Fragile X syndrome; Malignant pleural mesothelioma","","Fanconi anemia pathway; mTOR signaling pathway",665.1,671.9,630.2,716.4,715.8,763.1,0.896096205529996,-0.1582744655172212,0.020043249932908052,1.6980318579797602,0.095775823424814,1.0187441055175213,1634]
["Low","Q9Y4U1","Methylmalonic aciduria and homocystinuria type C protein [OS=Homo sapiens]",3,1,1,1,282,31.7,7.81,0,"other metabolic processes","cytosol;other cell component","other molecular function","MMACHC","ENSG00000132763","","Cobalamin (Cbl, vitamin B12) transport and metabolism; Defective MMADHC causes MMAHCD; Defective MMACHC causes MAHCC","Vitamin digestion and absorption",27,24.3,23.2,25.4,32.7,26.6,0.8795749704840613,-0.18512154398267486,0.24957484353210313,0.6027991924903924,0.44766376712581235,0.34904805498915525,4353]
["High","Q9Y4W2","Ribosomal biogenesis protein LAS1L [OS=Homo sapiens]",44,25,55,25,734,83,4.73,103.69,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LAS1L","ENSG00000001497","","Major pathway of rRNA processing in the nucleolus and cytosol","",2226.9,2161,2328.7,2581.5,2608.2,2526.7,0.8704318075786636,-0.20019681794346628,3.5867810081947754E-3,2.445295138472046,0.036513150080814606,1.4375506977623915,767]
["High","Q9Y4W6","AFG3-like protein 2 [OS=Homo sapiens]",29,22,59,21,797,88.5,8.66,131.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","AFG3L2","ENSG00000141385","Ciliary landscape","Processing of SMDT1","Spinocerebellar ataxia",3066.9,2991.9,3051.9,2966.1,3029.5,3013.7,1.0112550364623223,0.016146887882567525,0.3200660915158969,0.4947603335021477,0.5212924577714065,0.2829185585411473,4794]
["High","Q9Y4X0","AMME syndrome candidate gene 1 protein [OS=Homo sapiens]",10,3,4,2,333,35.4,8.63,6.99,"","mitochondrion;nucleus","","AMMECR1","ENSG00000101935","","","",162.4,146,143.2,132,161.2,138.8,1.0453703703703703,0.06401417372216983,0.5731435851686573,0.24173656401041568,0.7411568587275382,0.13008986803885922,6038]
["High","Q9Y4X5","E3 ubiquitin-protein ligase ARIH1 [OS=Homo sapiens]",37,15,42,15,557,64.1,5.08,85.92,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ARIH1","ENSG00000166233","","ISG15 antiviral mechanism","",1528.1,1497.6,1469.6,1428.7,1398.7,1422.7,1.0576927601703487,0.08092061256465267,0.01312885660376298,1.8817730951061784,0.07543054625620409,1.1224527471800374,1359]
["High","Q9Y4Y9","U6 snRNA-associated Sm-like protein LSm5 [OS=Homo sapiens]",32,2,2,2,91,9.9,4.54,0,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM5","ENSG00000106355","","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",117.4,144.8,112.9,124.7,116.7,117.9,1.0439743946562763,0.06208632765930583,0.6352524963659417,0.19705361961750162,0.7871848106055028,0.10392329457399299,6301]
["Low","Q9Y4Z0","U6 snRNA-associated Sm-like protein LSm4 [OS=Homo sapiens]",5,1,1,1,139,15.3,9.99,2.19,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM4","ENSG00000130520","Ciliary landscape","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",134.6,130,103.2,149.4,113.4,115.5,0.972244250594766,-0.040609296637438355,0.8295098232033377,0.08117846661642131,0.9090263437995313,0.041423530638333726,7125]
["High","Q9Y508-1","E3 ubiquitin-protein ligase RNF114 [OS=Homo sapiens]",27,5,13,5,228,25.7,7.25,31.58,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","RNF114","ENSG00000124226; ENSPPAG00000043607; ENSPTRG00000013613","","Antigen processing: Ubiquitination & Proteasome degradation","",495.9,495.2,513.5,498.8,443.6,454.7,1.076945100565457,0.10694470748592913,0.1157050644241257,0.9366476315122436,0.2790933404459603,0.5542505262561814,3237]
["High","Q9Y512","sorting and assembly machinery component 50 homolog [OS=Homo sapiens]",33,13,45,13,469,51.9,6.9,78.11,"cell organization and biogenesis;transport","other membranes;mitochondrion","","SAMM50","ENSG00000100347","","RAC2 GTPase cycle; Mitochondrial protein import; Cristae formation","",1254.7,1295.8,1202.3,1199.6,1360,1327.4,0.9654746591201441,-0.050689701730578234,0.46860382551721724,0.3291941702968104,0.6587790186601427,0.18126024105241378,5554]
["High","Q9Y520","Protein Prrc2c [OS=Homo sapiens]",27,63,184,62,2896,316.7,9.13,350.47,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;other cell component","other molecular function","PRRC2C","ENSG00000117523","VEGFA-VEGFR2 signaling pathway","","",9300.8,7569.2,8902.6,10781.8,8622.3,9147.1,0.9026800975090365,-0.14771329600448307,0.3294612219578236,0.4821956951240142,0.5314944671584064,0.2745012521097912,4840]
["High","Q9Y530","O-acetyl-ADP-ribose deacetylase 1 [OS=Homo sapiens]",14,2,3,2,152,17,8.31,5.34,"protein metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","OARD1","ENSG00000124596","","","",131.3,133.5,130.2,140.1,130.6,140.8,0.959902794653706,-0.059039777357160365,0.1840494037384122,0.735065585191163,0.3730679502568854,0.4282120589850245,3852]
["High","Q9Y535","DNA-directed RNA polymerase III subunit RPC8 [OS=Homo sapiens]",27,3,4,3,204,22.9,4.58,7.21,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR3H","ENSG00000100413","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",84.9,89.1,89.8,114.3,113.2,109.1,0.7837195484254308,-0.3515906120784043,3.8472265096815741E-4,3.4148522433763477,0.01540468953209935,1.8123470500802301,195]
["High","Q9Y546","Leucine-rich repeat-containing protein 42 [OS=Homo sapiens]",7,3,3,3,428,48.5,7.46,8.42,"","","","LRRC42","ENSG00000116212","","","",163.2,161.9,179,273.3,275.9,285.6,{"$f":"AVERAGE(T7682:V7682)/AVERAGE(W7682:Y7682)","v":0.6038572113080977},{"$f":"LOG(Z7682,2)","v":-0.7277206461504712},{"$f":"TTEST(T7682:V7682,W7682:Y7682,2,2)","v":7.7550974128246818E-5},{"$f":"-LOG10(AB7682)","v":4.110412742584545},{"$f":"AB7682*7808/AF7682","v":0.00840997230546321},{"$f":"-LOG10(AD7682)","v":2.075205434357178},72]
["High","Q9Y547","Intraflagellar transport protein 25 homolog [OS=Homo sapiens]",42,4,11,4,144,16.3,5.03,29.53,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","HSPB11","ENSG00000081870","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis","Intraflagellar transport","",213.8,232.3,211.3,219.1,238.6,225.9,0.9616734932709188,-0.05638094059582906,0.3745878465362521,0.42644631737152844,0.5763117055674988,0.2393425592981436,5075]
["High","Q9Y548","Protein YIPF1 [OS=Homo sapiens]",6,2,4,2,306,34.3,5.31,12.28,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","YIPF1","ENSG00000058799","","","",276.7,254.6,258,247.6,253.3,268,1.0265314085056572,0.037777769874311355,0.4996435219733672,0.3013397389735628,0.685024867351721,0.16429366273004656,5695]
["High","Q9Y570","Protein phosphatase methylesterase 1 [OS=Homo sapiens]",41,14,44,14,386,42.3,5.97,87.1,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","nucleus","enzyme regulator activity;other molecular function","PPME1","ENSG00000214517","","Cyclin A/B1/B2 associated events during G2/M transition","",1684.4,1797.9,1752.5,1649.5,1713.7,1695.1,1.0348931459185895,0.04948181524964734,0.19741851069819513,0.7046121286816669,0.3887626056825997,0.4103155156766541,3965]
["High","Q9Y573-1","actin-binding protein IPP [OS=Homo sapiens]",3,2,2,2,584,65.2,5.73,2.39,"","cytoskeleton;other cell component","cytoskeletal activity","IPP","ENSG00000197429; ENSPPAG00000037424","","","",124.3,131.9,106.8,116,122.5,120.1,1.0122699386503067,0.017594060014738132,0.8576609169764127,0.0666843799750601,0.92418112610431,0.03424290501494271,7246]
["High","Q9Y575","Ankyrin repeat and SOCS box protein 3 [OS=Homo sapiens]",2,1,3,1,518,57.7,6.27,5.21,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","","ASB3","ENSG00000115239","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",33,24.7,25.4,27.5,27.2,38.4,0.8925886143931258,-0.16393269078844908,0.5037898853774943,0.29775055610911855,0.6876908085712369,0.16260678024350736,5720]
["High","Q9Y576","Ankyrin repeat and SOCS box protein 1 [OS=Homo sapiens]",3,1,1,1,335,37,8.21,2.49,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","","ASB1","ENSG00000065802","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",65.1,75.6,62.8,47.8,74.7,63.4,1.0946745562130176,0.13050202423412757,0.538705236786771,0.2686488026301298,0.7150986890226296,0.14563401814254495,5882]
["High","Q9Y580","RNA-binding protein 7 [OS=Homo sapiens]",6,2,4,2,266,30.5,9.57,11.13,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RBM7","ENSG00000076053","","","",362,380.2,372.5,558.4,461.2,491.5,0.7376745417245715,-0.4389436479830335,0.010610609622094851,1.974259663421368,0.067685980334409,1.169501276572275,1224]
["High","Q9Y587-1","AP-4 complex subunit sigma-1 [OS=Homo sapiens]",7,1,3,1,144,17,5.19,5.1,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","AP4S1","ENSCANG00000008358; ENSCATG00000035780; ENSG00000100478; ENSGGOG00000003198; ENSMMUG00000003123; ENSPANG00000017427; ENSPCOG00000016646; ENSPPAG00000041450; ENSPTRG00000006239; ENSRROG00000019504","","Lysosome Vesicle Biogenesis","Lysosome",62.1,75.2,63.8,67.1,83.9,66.4,0.9250229990800369,-0.11243885872195708,0.4836135289712424,0.31550155835847005,0.6728536055252068,0.17207941605615698,5612]
["High","Q9Y592","Centrosomal protein of 83 kDa [OS=Homo sapiens]",2,2,4,2,693,82,6.28,6.88,"","","","","","","","",54.5,48.8,46.4,52.9,53.6,45.4,0.9855167873601053,-0.02104764844366678,0.8467623219204812,0.07223847486858702,0.9190325562350732,0.03666910369244396,7194]
["High","Q9Y597","BTB/POZ domain-containing protein KCTD3 [OS=Homo sapiens]",9,6,8,6,815,88.9,7.03,12.51,"cell organization and biogenesis","plasma membrane;other membranes","","KCTD3","ENSG00000136636","","CDC42 GTPase cycle","",242.7,244.4,272.5,301.3,265.5,252.1,0.9275857858102334,-0.10844738238318583,0.3237350713027282,0.4898102494754286,0.5251866687578853,0.27968630649415166,4813]
["High","Q9Y5A7","NEDD8 ultimate buster 1 [OS=Homo sapiens]",24,16,25,16,615,70.5,5.96,60.75,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","","NUB1","ENSG00000013374","","","",1522.8,1479.2,1445.3,1196,1184,1180.8,1.2489609076611998,0.3207283214567228,2.0810456048619765E-4,3.6817184023818927,0.011774495712146605,1.929057684124494,138]
["High","Q9Y5A9-1","YTH domain-containing family protein 2 [OS=Homo sapiens]",18,10,41,7,579,62.3,8.79,79.38,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity","YTHDF2","ENSCSAG00000001018; ENSG00000198492; ENSMFAG00000026128; ENSMMUG00000011391; ENSMNEG00000041161; ENSNLEG00000009856; ENSPTRG00000000439; ENSRBIG00000043898; ENSRROG00000038863","","","",1746.4,1749.3,1725.6,2101.9,2112.3,2144.3,0.8211527876071398,-0.28427741318256694,1.3731790679857287E-5,4.862272825350845,0.005360891081416285,2.2707630163561916,20]
["High","Q9Y5B0","RNA polymerase II subunit A C-terminal domain phosphatase [OS=Homo sapiens]",25,19,43,19,961,104.3,5.27,78.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CTDP1","ENSG00000060069","","TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1870.2,1677.2,1829,1681.5,1655.2,1709.4,1.0654564911515823,0.09147168060868437,0.1440788818038425,0.8413996707347845,0.32077784691314576,0.49379563195765175,3507]
["High","Q9Y5B6","PAX3- and PAX7-binding protein 1 [OS=Homo sapiens]",15,12,23,12,917,104.7,5.68,46.07,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity","PAXBP1","ENSG00000159086; ENSG00000263141","","","",1129.5,1115.3,1038.8,1193.4,1133.5,1173.7,0.9380106267497001,-0.09232382772000552,0.09506821587214308,1.0219646563388414,0.24817540271805189,0.6052412647115242,2991]
["High","Q9Y5B8","Nucleoside diphosphate kinase 7 [OS=Homo sapiens]",15,4,8,4,376,42.5,6.47,11.18,"other metabolic processes","cytosol;cytoskeleton","kinase activity;other molecular function","NME7","ENSG00000143156","Pyrimidine metabolism; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",204.5,196.9,192,210.4,220.5,224.9,0.9048490393412625,-0.14425097491279398,0.020882450225147467,1.6802185450936382,0.09810479624425476,1.008309759883095,1662]
["High","Q9Y5B9","FACT complex subunit SPT16 [OS=Homo sapiens]",44,50,246,50,1047,119.8,5.66,516.81,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","SUPT16H","ENSG00000092201","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation","",12203.3,12613.9,11907.6,11567.9,12787.2,12232.8,1.0037416741600365,0.005388020920329635,0.9162591447279693,0.037981677851414056,0.9557984505058096,0.019633677871849792,7485]
["Medium","Q9Y5E1","Protocadherin beta-9 [OS=Homo sapiens]",1,1,1,1,797,87,5.02,2.2,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;other cell component","other molecular function","PCDHB9","ENSG00000177839","","","",72.2,71.5,82.2,79.9,97.1,85.3,0.8612276019824627,-0.21553353687190005,0.11945602016343873,0.9227919584475559,0.28514601205629153,0.5449326979139022,3271]
["Low","Q9Y5F9-1","Protocadherin gamma-B6 [OS=Homo sapiens]",1,1,1,1,930,101,5.26,0,"cell adhesion","plasma membrane;other membranes","other molecular function","PCDHGB6","ENSG00000253305","","","",111.6,104.2,112.8,91.1,89.9,101.3,1.1640099185263904,0.21910335150038143,0.026670630116012672,1.5739667236174144,0.11492509930785151,0.9395851122995733,1812]
["High","Q9Y5J1","U3 small nucleolar RNA-associated protein 18 homolog [OS=Homo sapiens]",25,11,31,11,556,62,8.76,68.25,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","UTP18","ENSG00000011260","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1284.1,1160.4,1316.8,1768.2,1663.6,1761.5,0.7242601043652398,-0.4654201877894266,1.2205055808945742E-3,2.9134602303834773,0.02353014216203663,1.6283754489395106,405]
["High","Q9Y5K3","Choline-phosphate cytidylyltransferase B [OS=Homo sapiens]",26,8,15,5,369,41.9,6.4,29.65,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PCYT1B","ENSG00000102230","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways","Synthesis of PC","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer",210.7,208.3,249.8,263.8,235.4,233.1,0.9132869042742043,-0.13085994842142767,0.2733909221330392,0.5632159101521835,0.47352181011862693,0.32466001286761703,4508]
["High","Q9Y5K5-1","Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",58,14,68,1,329,37.6,5.33,154.39,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UCHL5","ENSCANG00000036448; ENSCATG00000035323; ENSG00000116750; ENSGGOG00000004347; ENSMFAG00000038349; ENSMLEG00000030039; ENSMNEG00000039813; ENSPPAG00000029294; ENSPTRG00000001793","TGF-beta signaling pathway","UCH proteinases; Downregulation of TGF-beta receptor signaling","",20.8,19.5,26.7,27.8,24.5,24.5,0.8723958333333334,-0.19694521537602136,0.2570909027263573,0.5899132907847732,0.45508178836712715,0.3419105439045451,4411]
["High","Q9Y5K5-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",58,14,68,1,328,37.5,5.4,158.34,"","","","UCHL5","","","","",2718.9,2859.9,2733.5,2561.5,2820.3,2630,1.0375071769140518,0.053121316278838863,0.32539027806408144,0.48759542695600366,0.5266681780937702,0.2784629214294633,4824]
["High","Q9Y5K6","CD2-associated protein [OS=Homo sapiens]",40,21,42,21,639,71.4,6.4,76.66,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CD2AP","ENSG00000198087","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis","Nephrin family interactions","Bacterial invasion of epithelial cells",2066.5,1900.8,2086.1,2280.5,2116.2,2175.8,0.9210193990110307,-0.1186965514238754,0.0848002126238696,1.0716030588133625,0.23151051054796287,0.6354292872837702,2860]
["High","Q9Y5K8","V-type proton ATPase subunit D [OS=Homo sapiens]",47,12,31,12,247,28.2,9.36,54.53,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol","transporter activity","ATP6V1D","ENSG00000100554","Proximal tubule transport","Amino acids regulate mTORC1; Neutrophil degranulation; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",871.6,872.1,816.6,727.5,756.9,763.2,1.1391261790354155,0.18792756073020037,0.008286965211730326,2.0816044842992065,0.058556221152208494,1.2324269576617004,1105]
["High","Q9Y5L0-2","transportin-3 [OS=Homo sapiens]",34,23,66,23,923,104.1,5.57,160,"transport","other membranes;nucleus;other cell component","other molecular function","TNPO3","ENSCANG00000033070; ENSCATG00000030018; ENSG00000064419; ENSGGOG00000008339; ENSMLEG00000037881; ENSMMUG00000004311; ENSMNEG00000045277; ENSPPAG00000034975; ENSPPYG00000017990; ENSPTRG00000019676","","","Nucleocytoplasmic transport",2513.7,2558.1,2506.1,2543.6,2540.7,2587.5,0.9877603691441383,-0.017767008724349026,0.23110990215685706,0.6361814462995499,0.4265971905533664,0.36998200901595685,4230]
["High","Q9Y5M8","signal recognition particle receptor subunit beta [OS=Homo sapiens]",30,7,22,7,271,29.7,9.04,48.58,"transport","other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SRPRB","ENSG00000144867","","SRP-dependent cotranslational protein targeting to membrane; XBP1(S) activates chaperone genes","Protein export",984.9,974.4,997.6,908.9,1032.3,994.4,1.007255756915111,0.010430051154564824,0.8575781259950768,0.06672630493767193,0.9242194627701256,0.0342248900862299,7245]
["Low","Q9Y5N1","histamine H3 receptor [OS=Homo sapiens]",2,1,1,1,445,48.6,9.29,2.08,"cell-cell signaling;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","HRH3","ENSG00000101180","GPCRs, class A rhodopsin-like; Monoamine transport","Histamine receptors","Neuroactive ligand-receptor interaction",77.2,87.4,100.1,90.6,84.3,108.4,0.9343452170843631,-0.09797240688269958,0.5611438816893127,0.25092576795605015,0.7335361507165835,0.13457847804448675,5973]
["High","Q9Y5N5","HemK methyltransferase family member 2 [OS=Homo sapiens]",24,5,9,5,214,22.9,5.11,15.88,"protein metabolism;DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","N6AMT1","ENSG00000156239","","Eukaryotic Translation Termination; Methylation","",430.3,455.8,438,427.1,470.6,431,0.9965379694438171,-0.005003320144431113,0.9274258273199811,0.03272081386789856,0.9625602631549133,0.016572071028450763,7523]
["High","Q9Y5N6","Origin recognition complex subunit 6 [OS=Homo sapiens]",41,8,12,8,252,28.1,8.66,17.75,"DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC6","ENSG00000091651","Cell cycle; G1 to S cell cycle control; DNA replication","Assembly of the ORC complex at the origin of replication; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDT1 association with the CDC6:ORC:origin complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle",603.2,613.1,607.5,528.6,532.4,510.3,1.1606949659517598,0.2149888775181876,3.4071643880884047E-4,3.4676069121857522,0.014617109638568278,1.8351384955121914,182]
["High","Q9Y5P4-1","Collagen type IV alpha-3-binding protein [OS=Homo sapiens]",24,14,39,14,624,70.8,5.48,67.26,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus","transporter activity;kinase activity;other molecular function","CERT1","ENSG00000113163; ENSPTRG00000016996","Sphingolipid pathway","","",1301,1239.6,1329.5,1320.5,1208.4,1291.2,1.0130886626004554,0.018760440177089922,0.7167037548784256,0.1446603202148343,0.8423939361870763,0.07448476799774839,6643]
["High","Q9Y5P6","Mannose-1-phosphate guanyltransferase beta [OS=Homo sapiens]",20,5,17,5,360,39.8,6.61,37.01,"other metabolic processes","other cell component","other molecular function","GMPPB","ENSG00000173540","","Synthesis of GDP-mannose","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",347.2,365.7,348.4,353.3,330.4,344.5,1.0321921805096284,0.04571160647407727,0.2854169115718676,0.5445202975677408,0.4858372019954529,0.31350923304108796,4587]
["High","Q9Y5Q0","fatty acid desaturase 3 [OS=Homo sapiens]",16,5,7,4,445,51.1,7.77,15.7,"other metabolic processes","other membranes;ER/Golgi","other molecular function","FADS3","ENSG00000221968","","","",124.3,129.8,142.4,146.8,142.1,137.4,0.9300961764015951,-0.1045481893725957,0.1734550646244152,0.7608130148975942,0.3601002777419393,0.44357654366135807,3761]
["High","Q9Y5Q8-1","general transcription factor 3C polypeptide 5 [OS=Homo sapiens]",30,13,22,13,519,59.5,6.9,44.41,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity","GTF3C5","ENSG00000148308","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",974.1,926.7,939.9,1020.8,1073.9,1013,0.9140843710782897,-0.12960076098417123,0.02007850015958273,1.697268731603947,0.09576843570312887,1.018777606357253,1637]
["High","Q9Y5Q9","General transcription factor 3C polypeptide 3 [OS=Homo sapiens]",24,14,47,14,886,101.2,5.07,80.98,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","nucleic acid binding activity","GTF3C3","ENSG00000119041","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1462.4,1336,1497.1,1504,1574.9,1528.6,0.9322843190450353,-0.10115809373879893,0.12217694819479695,0.9130107271227559,0.28951672579817134,0.5383263413941491,3295]
["Medium","Q9Y5R2","Matrix metalloproteinase-24 [OS=Homo sapiens]",2,1,1,1,645,73.2,9.23,0,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","MMP24","ENSG00000125966","Matrix metalloproteinases","Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action",41.1,52,37.2,29,51.9,42,1.0602115541090318,0.08435216819547292,0.7725036105827564,0.11209948206169977,0.8732746766222906,0.05884913340921135,6907]
["High","Q9Y5S2","Serine/threonine-protein kinase MRCK beta [OS=Homo sapiens]",16,25,42,23,1711,194.2,6.37,97.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPB","ENSG00000198752","VEGFA-VEGFR2 signaling pathway","CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle","",1955.3,1883.9,1827.4,1840.5,1934.7,1872.1,1.0034175623749404,0.004922094290688462,0.8960089169992893,0.0476876682571644,0.9451550424115712,0.024496944357622025,7402]
["High","Q9Y5S9","RNA-binding protein 8A [OS=Homo sapiens]",48,8,62,2,174,19.9,5.72,123.74,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","RBM8A","ENSG00000265241","","mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",2156.6,1868,1751.7,2680.6,1785.4,1554.8,0.9593907786340685,-0.05980952201758229,0.8337306786877182,0.07897421752701284,0.9114770567339266,0.04025425872514055,7142]
["High","Q9Y5S9-2","Isoform 2 of RNA-binding protein 8A [OS=Homo sapiens]",47,7,53,1,173,19.7,5.92,108.93,"","","","RBM8A","","","","",159.8,142.7,128.8,202.2,142.5,124.9,0.9184412265758093,-0.12274069237555156,0.6371400493548345,0.1957650951735769,0.7885226668826356,0.103185817920925,6309]
["High","Q9Y5T5-1","ubiquitin carboxyl-terminal hydrolase 16 [OS=Homo sapiens]",12,6,11,6,823,93.5,6.93,26.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","USP16","ENSG00000156256","","Ub-specific processing proteases","",193.8,183.1,197.3,199.1,200.8,192.6,0.9691139240506329,-0.04526182346580208,0.2851775566177772,0.5448846563117179,0.48553562190833066,0.3137789020470026,4586]
["High","Q9Y5U2-1","Protein TSSC4 [OS=Homo sapiens]",7,3,5,3,329,34.3,5.19,2.98,"","","","TSSC4","ENSG00000184281","","","",55.4,54.9,63.9,59.9,57.3,52.9,1.024103468547913,0.03436148293547945,0.7208748031327801,0.14214015418463072,0.845006825230558,0.0731397831828543,6661]
["High","Q9Y5U9","immediate early response 3-interacting protein 1 [OS=Homo sapiens]",24,1,4,1,82,9,8.22,14.62,"transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","","IER3IP1","ENSG00000134049","","","",189.4,212.9,187.5,186.7,197.1,190.4,1.0271682340647859,0.03867249185455515,0.5829397898728641,0.23437629991739406,0.7475109015154086,0.12638246931328126,6089]
["High","Q9Y5V3","Melanoma-associated antigen D1 [OS=Homo sapiens]",15,10,29,7,778,86.1,5.83,61.46,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","MAGED1","ENSG00000179222","","NRAGE signals death through JNK; Caspase activation via Dependence Receptors in the absence of ligand","Neurotrophin signaling pathway",688.5,723,727.3,725.7,748.1,750.2,0.9616906474820144,-0.05635520621225158,0.12304959953767561,0.9099197953611031,0.2906144202027136,0.5366828399378963,3306]
["High","Q9Y5W7","Sorting nexin-14 [OS=Homo sapiens]",3,4,4,4,946,110.1,6.7,1.82,"cell organization and biogenesis;other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX14","ENSG00000135317","","","",90,121,107.9,128.2,137.6,114.3,0.8389897395422258,-0.2532749276097047,0.14394528142238563,0.8418025668804292,0.32066326885762825,0.4939507845244713,3505]
["High","Q9Y5W8","Sorting nexin-13 [OS=Homo sapiens]",3,3,3,3,968,112.1,6.58,7.79,"transport;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","SNX13","ENSG00000071189","","","",50.3,54.9,41.3,49.9,48.3,51.4,0.9792780748663102,-0.03020951057802632,0.8131229481632394,0.08984378199288698,0.8990178390340658,0.04623169056132989,7062]
["High","Q9Y5X1","Sorting nexin-9 [OS=Homo sapiens]",29,10,25,10,595,66.6,5.58,34.17,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","SNX9","ENSG00000130340","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","Salmonella infection",513.9,567.8,537.7,604.6,594.2,658.8,0.8717700258397931,-0.197980494677559,0.0352472668177319,1.4528745539065666,0.13583941723240409,0.8669741902721929,2026]
["High","Q9Y5X2","Sorting nexin-8 [OS=Homo sapiens]",13,6,12,6,465,52.5,7.39,32.15,"transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX8","ENSG00000106266","","","",379.5,366.4,374.4,383,411.7,396.1,0.9407961034598588,-0.08804600997964519,0.06171365707061651,1.20961871709997,0.1916707376322091,0.7174441857912734,2514]
["High","Q9Y5X3","sorting nexin-5 [OS=Homo sapiens]",38,14,50,13,404,46.8,6.76,106.93,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","SNX5","ENSG00000089006","","Golgi Associated Vesicle Biogenesis","Endocytosis",1928.3,2062.9,1905.9,1809.2,1862.5,1835.6,1.0707787845223613,0.09866046007228443,0.06476280206957943,1.1886743690442079,0.19706467597789407,0.7053912164244821,2566]
["High","Q9Y5Y0","Feline leukemia virus subgroup C receptor-related protein 1 [OS=Homo sapiens]",17,6,22,6,555,59.8,5.97,57.32,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion","transporter activity;other molecular function","FLVCR1","ENSG00000162769","","","",653.9,641.8,663.1,687.3,662.2,697.7,0.9568190699491989,-0.06368195133068044,0.07327804512786674,1.135026125059429,0.2121449671332531,0.6733672668536846,2697]
["High","Q9Y5Y2","Cytosolic Fe-S cluster assembly factor NUBP2 [OS=Homo sapiens]",24,5,9,5,271,28.8,5.83,21.95,"cell organization and biogenesis;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NUBP2","ENSG00000095906","","Cytosolic iron-sulfur cluster assembly","",384.7,389.9,377.6,325.1,319.8,366.9,1.1387626013046053,0.18746701867195856,0.037820189931395694,1.4222762944769662,0.14231327372739158,0.8467545908664423,2075]
["High","Q9Y5Z4-1","Heme-binding protein 2 [OS=Homo sapiens]",10,2,2,2,205,22.9,4.63,3.08,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","HEBP2","ENSG00000051620","","Neutrophil degranulation","",110.8,119.3,110.5,107.3,117.3,112.7,1.0097835754521198,0.014046116660415964,0.8009486536625896,0.09639532429748734,0.8911095878879309,0.050068883518239335,7018]
["Medium","Q9Y5Z6","Beta-1,3-galactosyltransferase 1 [OS=Homo sapiens]",3,1,1,1,326,38,9.29,2.12,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B3GALT1","ENSG00000172318","Ganglio sphingolipid metabolism; Metabolism of spingolipids in ER and Golgi apparatus","Lewis blood group biosynthesis","Glycosphingolipid biosynthesis; Metabolic pathways",30.9,34.3,30.7,18.2,27.2,22,1.422848664688427,0.5087822238362721,0.02927297241568945,1.5335331765006253,0.12125377645713699,0.9163047263838014,1885]
["High","Q9Y5Z9-1","UbiA prenyltransferase domain-containing protein 1 [OS=Homo sapiens]",6,1,1,1,338,36.8,8.15,3.75,"other metabolic processes;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","UBIAD1","ENSG00000120942; ENSGGOG00000001270","7q11.23 copy number variation syndrome","Metabolism of vitamin K","",27.3,28.8,26.4,27.2,29.2,24.8,1.0160098522167489,0.022914391948002075,0.7802027527521311,0.10779252172103393,0.8787973302782227,0.056111271104277924,6932]
["High","Q9Y605","MORF4 family-associated protein 1 [OS=Homo sapiens]",19,1,2,1,127,14.6,4.7,9.33,"","nucleus;other cell component","","MRFAP1","ENSG00000179010","","","",34.2,36.2,39.8,35.1,28.3,30.3,1.176093916755603,0.23400327091197085,0.10179049129114641,0.9922927895106596,0.2585491724142066,0.5874568480157505,3074]
["High","Q9Y606","tRNA pseudouridine synthase A [OS=Homo sapiens]",52,20,47,20,427,47.4,8.41,88.3,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","PUS1","ENSG00000177192","","","",1784.9,1811,1819.2,1641,1708,1671.4,1.0786192335272093,0.10918566477876815,3.9012713524347866E-3,2.4087938413399463,0.03807640839976352,1.4193440236732544,800]
["High","Q9Y608","Leucine-rich repeat flightless-interacting protein 2 [OS=Homo sapiens]",4,3,9,1,721,82.1,6.95,14.51,"cell-cell signaling;signal transduction;other biological processes","","other molecular function","LRRFIP2","ENSG00000093167","VEGFA-VEGFR2 signaling pathway","","",68.6,68.4,45.2,61.3,55.7,46.2,1.1164215686274508,0.15888190183055492,0.5173460567548471,0.2862188567849829,0.6997121100193741,0.1550806096249785,5773]
["High","Q9Y613","FH1/FH2 domain-containing protein 1 [OS=Homo sapiens]",28,19,40,19,1164,126.5,6.39,72.26,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FHOD1","ENSG00000135723","VEGFA-VEGFR2 signaling pathway","","Salmonella infection",572.8,527.2,538.2,597.5,559.5,549.2,0.9601453522447545,-0.058675269169006346,0.3227542150808536,0.49112807725859253,0.5242489934161234,0.28046239472860396,4807]
["High","Q9Y617-1","phosphoserine aminotransferase [OS=Homo sapiens]",68,22,169,21,370,40.4,7.66,380.51,"other metabolic processes","cytosol;other cell component","other molecular function","PSAT1","ENSG00000135069; ENSGGOG00000015480; ENSPPAG00000036829; ENSPTRG00000021045","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Vitamin B6 metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors",8830.2,8970.8,8405.4,8565.1,9706.1,9361,0.9484007788015432,-0.07643124736408552,0.27723528738504044,0.5571514921653975,0.47763749424148183,0.3209015886981218,4532]
["High","Q9Y618-1","Nuclear receptor corepressor 2 [OS=Homo sapiens]",6,14,22,13,2525,274.6,7.59,28.1,"","","","","","","","",1033.9,916.8,981.7,1058.1,993.8,996.3,0.9620103667738338,-0.05587565410138488,0.38776621408291073,0.41143003351560975,0.5877846242592442,0.23078177873755334,5151]
["High","Q9Y619","mitochondrial ornithine transporter 1 [OS=Homo sapiens]",5,2,3,2,301,32.7,9.13,6.35,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A15","ENSG00000102743","","Urea cycle","",215.4,232.7,189.4,229.2,238.8,242.1,0.8977608787494719,-0.15559686482218835,0.13988564073150098,0.8542268635720248,0.3148535839814239,0.5018913587554493,3469]
["High","Q9Y620-1","DNA repair and recombination protein RAD54B [OS=Homo sapiens]",2,2,3,2,910,102.9,8.12,4.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RAD54B","ENSG00000197275","Homologous recombination; DNA repair pathways, full network","","Homologous recombination",87.1,68.8,100.5,65.4,68,64.1,1.2982278481012657,0.3765436086669132,0.10127998113269616,0.9944763882308147,0.2579237092903104,0.5885087340905357,3066]
["High","Q9Y624","Junctional adhesion molecule A [OS=Homo sapiens]",51,12,53,12,299,32.6,7.9,98.69,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","F11R","ENSG00000158769","1q21.1 copy number variation syndrome","Integrin cell surface interactions; Tight junction interactions; Cell surface interactions at the vascular wall; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Epithelial cell signaling in Helicobacter pylori infection",2327.7,2288.5,2400.9,2514.6,2428,2476.9,0.9457645393894468,-0.08044704466074837,0.031659232734713896,1.4994996145247583,0.1267018396681938,0.897217079260641,1951]
["High","Q9Y625","Glypican-6 [OS=Homo sapiens]",9,3,3,2,555,62.7,5.41,9.71,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC6","ENSG00000183098","miR-509-3p alteration of YAP1/ECM axis","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","",13.7,16.7,13.7,16.3,14.6,12.4,1.0184757505773672,0.02641163083079562,0.868241867492433,0.06135927587749532,0.930063451966102,0.03148742144744784,7289]
["High","Q9Y639-1","Isoform 1 of Neuroplastin [OS=Homo sapiens]",33,8,26,8,282,31.3,6.87,63.74,"","","","NPTN","","","","",1164.9,1315.6,1418.1,1379,1220,1300.5,0.9997692011796384,-3.3301074430057057E-4,0.9974043371619206,0.001128747606131993,0.9994523953491115,2.3788681805566624E-4,7792]
["Medium","Q9Y646","Carboxypeptidase Q [OS=Homo sapiens]",1,1,1,1,472,51.9,6.18,2.19,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CPQ","ENSG00000104324","","","",30.8,38.4,30.5,38.3,33.6,44.3,{"$f":"AVERAGE(T7746:V7746)/AVERAGE(W7746:Y7746)","v":0.8580034423407917},{"$f":"LOG(Z7746,2)","v":-0.22094465900633298},{"$f":"TTEST(T7746:V7746,W7746:Y7746,2,2)","v":0.24439522447199505},{"$f":"-LOG10(AB7746)","v":0.6119072845412822},{"$f":"AB7746*7808/AF7746","v":0.44243865353056744},{"$f":"-LOG10(AD7746)","v":0.3541469380285984},4313]
["High","Q9Y657","Spindlin-1 [OS=Homo sapiens]",47,10,30,9,262,29.6,6.96,54.87,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes","other membranes;cytosol;nucleus","other molecular function","SPIN1","ENSG00000106723","","","",825.1,867.3,906.4,998.3,1032.7,1008.6,0.8549809185419136,-0.22603587258724187,0.00456059161008001,2.340978816035673,0.04169683757787438,1.3798968820660429,854]
["High","Q9Y664","KICSTOR complex protein kaptin [OS=Homo sapiens]",11,4,6,4,436,48.1,5.26,6.99,"cell organization and biogenesis;stress response;other biological processes","other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity","KPTN","ENSG00000118162","","Amino acids regulate mTORC1","",74.3,77.1,74.6,59.1,76.4,80.7,1.0453283996299723,0.06395624956789983,0.6494998738394621,0.18742092894943027,0.7953724929326411,0.09942943267885081,6376]
["High","Q9Y666","Solute carrier family 12 member 7 [OS=Homo sapiens]",14,11,16,11,1083,119,6.71,33.91,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC12A7","ENSG00000113504","","Cation-coupled Chloride cotransporters","Collecting duct acid secretion",488.7,461.1,476.6,511.7,480.6,491.9,0.9610564613933433,-0.05730690407629397,0.18653532802966902,0.7292389047916886,0.3759596905667671,0.42485871651614526,3874]
["High","Q9Y672","Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",6,3,9,3,507,58.1,8.46,18.36,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG6","ENSG00000088035","GPCRs, other","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG6 causes CDG-1c","N-Glycan biosynthesis; Metabolic pathways",417.7,415.4,380.5,391.7,400.8,428.1,0.994265115516959,-0.008297504826357162,0.8928468247505263,0.049223041527560636,0.9434765201856963,0.025268903427690878,7389]
["High","Q9Y673","dolichyl-phosphate beta-glucosyltransferase [OS=Homo sapiens]",17,4,5,4,324,36.9,9.28,10.28,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ALG5","ENSG00000120697","","Synthesis of dolichyl-phosphate-glucose","N-Glycan biosynthesis; Metabolic pathways",113.5,128,124.3,129.2,128.2,124.9,0.9568401778707822,-0.06365012508593205,0.2923665720469334,0.5340722842636488,0.49304496642385653,0.30711347062296657,4630]
["High","Q9Y676","28S ribosomal protein S18b, mitochondrial [OS=Homo sapiens]",7,1,1,1,258,29.4,9.38,3.86,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPS18B","ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Viral carcinogenesis",20.5,25.1,20.8,39.2,24,23.9,0.762342135476464,-0.39148947725193955,0.2625702941108312,0.5807544093718314,0.46153733822993476,0.3357931589256512,4442]
["High","Q9Y678","Coatomer subunit gamma-1 [OS=Homo sapiens]",57,37,115,33,874,97.7,5.47,252.96,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","COPG1","ENSG00000181789","VEGFA-VEGFR2 signaling pathway","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",4019.8,4083.1,3916.4,3756.8,4107.5,3986.9,1.0141842176319695,0.020319728993371294,0.6481538537088263,0.18832189245380507,0.7945965284594937,0.09985333668083093,6369]
["High","Q9Y679-1","Ancient ubiquitous protein 1 [OS=Homo sapiens]",11,6,16,6,476,53,8.09,37.45,"","","","","","","","",667.5,684,666.4,734.7,740.9,681.9,0.935295480880649,-0.0965058780614335,0.07612611297702798,1.1184663448517012,0.2166154118530009,0.6643106472277799,2744]
["High","Q9Y692-1","Glucocorticoid modulatory element-binding protein 1 [OS=Homo sapiens]",17,8,12,7,573,62.6,4.83,30.46,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GMEB1","ENSG00000162419; ENSGGOG00000009221; ENSPPAG00000038756","","","",549.9,528.4,581.8,760.2,691.1,769.5,0.7475234149855907,-0.4198093247344451,0.003056695310070854,2.514747849383088,0.033615038001455246,1.4734663934435284,710]
["High","Q9Y696","Chloride intracellular channel protein 4 [OS=Homo sapiens]",74,15,177,14,253,28.8,5.59,365.42,"transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","transporter activity","CLIC4","ENSG00000169504","","","",6087.2,6351.8,5969.9,6314.1,5928.9,5654.4,1.028579570216903,0.04065340408837985,0.48563752107247704,0.3136877664031031,0.6742279097677633,0.17119327375623528,5624]
["High","Q9Y697","Cysteine desulfurase, mitochondrial [OS=Homo sapiens]",32,10,16,10,457,50.2,8.31,38.46,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","NFS1","ENSG00000244005","","","Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system",447.5,384.5,457.1,447.5,415.2,444.5,0.9861536107711137,-0.020115705650588837,0.8211064725805206,0.0856005244200562,0.9034948334144173,0.04407432658509077,7096]
["Low","Q9Y6A1","Protein O-mannosyl-transferase 1 [OS=Homo sapiens]",1,1,1,1,747,84.8,8.4,1.87,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","POMT1","ENSG00000130714","","O-linked glycosylation; Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2; Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1","Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Metabolic pathways",26.5,21,23.6,22.4,22.7,17.9,1.1285714285714288,0.17449773123213674,0.2909709292897539,0.5361503989168899,0.49228624396411663,0.30778229962018533,4615]
["High","Q9Y6A4","Cilia- and flagella-associated protein 20 [OS=Homo sapiens]",54,8,19,8,193,22.8,9.76,32.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","","CFAP20","ENSG00000070761","","","",774.5,882.2,699.3,596,825.6,675.5,1.12345620142101,0.16794388132743246,0.3710231283839085,0.4305990170253085,0.5729724261118587,0.2418662776410017,5056]
["High","Q9Y6A5","Transforming acidic coiled-coil-containing protein 3 [OS=Homo sapiens]",48,33,102,33,838,90.3,5.05,203.73,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","","TACC3","ENSG00000013810","","Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus","",5264,4539,5474.1,3591.5,2988.7,3141.8,1.5713947747377084,0.6520456682252882,0.005294917170376352,2.2761408292731815,0.04543155303988852,1.34264241693564,910]
["High","Q9Y6A9","Signal peptidase complex subunit 1 [OS=Homo sapiens]",17,2,5,2,102,11.8,9.31,8.44,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","translation activity;other molecular function","SPCS1","ENSG00000114902","","","Protein export",320.9,296,332.6,295.5,299,283.6,1.0813119234711308,0.11278275390695308,0.11290811815373356,0.9472748309482125,0.2748087863292866,0.5609693859017031,3208]
["High","Q9Y6B6","GTP-binding protein SAR1b [OS=Homo sapiens]",31,6,24,2,198,22.4,6.11,44.54,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SAR1B","ENSG00000152700","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Chylomicron assembly","Protein processing in endoplasmic reticulum; Legionellosis",116,134.1,138.2,120.6,125.7,116.2,1.0711724137931034,0.09919071211881825,0.3070346246706186,0.5128126458405076,0.5070487202682297,0.2949503090550711,4728]
["High","Q9Y6B7","AP-4 complex subunit beta-1 [OS=Homo sapiens]",5,2,3,2,739,83.2,5.86,0,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","AP4B1","ENSG00000134262","","Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis","Lysosome",32.9,45.2,45,35.5,46,33.9,1.0667244367417676,0.09318753783897468,0.6684753170392457,0.17491462411113406,0.8093433517510359,0.09186719638984048,6449]
["High","Q9Y6C9","Mitochondrial carrier homolog 2 [OS=Homo sapiens]",23,7,23,7,303,33.3,7.97,72.58,"other biological processes","other membranes;mitochondrion","","MTCH2","ENSG00000109919; ENSG00000285121","","","",1439.7,1580.2,1615.9,1456.3,1567.1,1589.3,1.0050079129360245,0.007206860517258213,0.9149367891925412,0.03860890927033261,0.954801717457279,0.020086808473883434,7482]
["High","Q9Y6D0","selenoprotein K [OS=Homo sapiens]",10,1,2,1,94,10.6,10.86,2.47,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","SELENOK","ENSG00000113811","Selenium micronutrient network","","",111.9,137.6,115.3,66.2,69.5,64.6,1.8212680978532203,0.8649433083520341,0.002586699602890738,2.5872540035918985,0.03126462925599208,1.504946716928347,646]
["High","Q9Y6D5","Brefeldin A-inhibited guanine nucleotide-exchange protein 2 [OS=Homo sapiens]",16,27,51,17,1785,201.9,6.33,82.37,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARFGEF2","ENSG00000124198","","Association of TriC/CCT with target proteins during biosynthesis","Endocytosis",769,818.2,798.4,844.8,866,873.1,0.9232555439451989,-0.11519807436605205,0.016471907876804727,1.7832560952819168,0.08568464803603684,1.0670969828665517,1501]
["High","Q9Y6D6","Brefeldin A-inhibited guanine nucleotide-exchange protein 1 [OS=Homo sapiens]",29,38,88,28,1849,208.6,5.85,167.77,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","ARFGEF1","ENSG00000066777","","","Endocytosis",3591,3581,3557.6,4155.9,4418.1,4217.3,0.8388201355608891,-0.2535666016870287,9.9889899798382884E-4,3.0004784225206227,0.021079468584480367,1.6761403419289824,370]
["High","Q9Y6D9","mitotic spindle assembly checkpoint protein MAD1 [OS=Homo sapiens]",40,31,76,31,718,83,5.92,179.87,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD1L1","ENSG00000002822","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; CCL18 signaling pathway","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Viral carcinogenesis",3039.4,2907.2,3153.3,2919.3,2905.5,2905,1.0423950147769712,0.05990208938923429,0.1584681830675426,0.8000579214921087,0.3418954333770027,0.46610669994167264,3619]
["High","Q9Y6E0","Serine/threonine-protein kinase 24 [OS=Homo sapiens]",38,13,53,8,443,49.3,5.69,111.9,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","STK24","ENSG00000102572","","Apoptotic cleavage of cellular proteins","",1162,1119.9,1221.7,1252.4,1170.4,1198.4,0.9675245774881255,-0.04762978518599947,0.36164095382468114,0.4417223939794454,0.563386386165824,0.24919365164292245,5012]
["High","Q9Y6E2","Basic leucine zipper and W2 domain-containing protein 2 [OS=Homo sapiens]",48,20,81,16,419,48.1,6.68,148.74,"developmental processes;other biological processes","other cell component","","BZW2","ENSG00000136261","","","",2289.7,2391.1,2219.8,2277.8,2426.4,2377.9,0.9743720083026219,-0.03745540669961833,0.41269650646813727,0.38436920746867576,0.610521849659571,0.21429878869407126,5278]
["High","Q9Y6G5","COMM domain-containing protein 10 [OS=Homo sapiens]",12,2,3,2,202,23,6.54,2.65,"","nucleus;other cell component","","COMMD10","ENSG00000145781","","Neddylation","",21.1,20,25.3,27.2,23.8,23,0.8972972972972973,-0.1563420291693873,0.28723568631957885,0.5417616040924478,0.4879756829380487,0.3116018194500599,4596]
["High","Q9Y6G9","Cytoplasmic dynein 1 light intermediate chain 1 [OS=Homo sapiens]",59,24,78,24,523,56.5,6.42,187.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","DYNC1LI1","ENSG00000144635","Ciliary landscape; Intraflagellar transport proteins binding to dynein","Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MHC class II antigen presentation; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection",3542.5,3392.4,3434,3394.5,3507.3,3516.2,0.9952870032635822,-0.006815490356742599,0.7967659813058786,0.09866921681143084,0.88797441936002,0.05159954513446906,7006]
["High","Q9Y6H1","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 [OS=Homo sapiens]",34,3,6,3,151,15.5,9.22,12.94,"cell organization and biogenesis;stress response;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","CHCHD2","ENSG00000106153","","Mitochondrial protein import","",214.9,220.8,197,244.9,210,214.9,0.9446103314422216,-0.08220878019186795,0.39685068295777015,0.40137286796125415,0.5960011795603518,0.22475288073619826,5199]
["High","Q9Y6I3","epsin-1 [OS=Homo sapiens]",18,8,17,1,576,60.3,4.83,58.15,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","EPN1","ENSG00000063245","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway","Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation","Endocytosis",202.3,178,179.2,193.3,170.3,159,1.0706084959816302,0.0984310065437354,0.3916973886313876,0.40704932379744685,0.5908758134532215,0.2285037867994554,5176]
["High","Q9Y6I3-1","Isoform 2 of Epsin-1 [OS=Homo sapiens]",16,8,17,1,662,69,5.05,58.01,"","","","EPN1","","","","",658.4,640.5,695.7,635.2,573,563.9,1.1255572484622764,0.17063943748702784,0.055276823599640534,1.2574569210025797,0.1788650802594253,0.7474744382527301,2413]
["High","Q9Y6I4-1","Ubiquitin carboxyl-terminal hydrolase 3 [OS=Homo sapiens]",21,8,11,8,520,58.9,8.18,20.69,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","USP3","ENSG00000140455","","Ub-specific processing proteases","",465.8,485.3,458,522.9,506,536.8,0.899980839241234,-0.15203380836273117,0.01233233554281767,1.9089546673373816,0.07278221913705243,1.1379747068662474,1323]
["High","Q9Y6I9","Testis-expressed protein 264 [OS=Homo sapiens]",15,3,6,3,313,34.2,4.86,12.37,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TEX264","ENSG00000164081","","Platelet degranulation","",292.9,263.8,270.2,274.8,255.9,222,1.0985784509100573,0.13563789816137622,0.23682282642069666,0.6255764399948165,0.43314889404844215,0.3633627901401279,4269]
["High","Q9Y6J0","Calcineurin-binding protein cabin-1 [OS=Homo sapiens]",7,11,17,11,2220,246.2,6.02,37.06,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity","CABIN1","ENSG00000099991","","Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",638.7,701.9,669.6,679.6,656.9,670,1.0018440069773236,2.657889890253388E-3,0.9523488771327373,0.021203925924719213,0.9764858874133175,0.010334028938145183,7615]
["High","Q9Y6J9","TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L [OS=Homo sapiens]",15,7,13,7,622,67.8,8.97,17.17,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF6L","ENSG00000162227","","HATs acetylate histones","Basal transcription factors",573.9,545,604.7,613.2,611.7,637.8,0.9253234551994418,-0.1119703339694413,0.07317819210708089,1.135618324114475,0.2120131072252644,0.6736372889785972,2695]
["High","Q9Y6K1","DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",44,31,99,4,912,101.8,6.57,170.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT3A","ENSG00000119772","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency","RMTs methylate histone arginines; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer",2873.4,2881.8,2836.2,3055.6,3133.7,3100.2,0.9248506378168903,-0.11270770383152877,9.4220352921090043E-4,3.0258552733582937,0.02072316945374285,1.6835438217547523,355]
["High","Q9Y6K1-2","Isoform 2 of DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",49,28,94,1,723,81.6,6.81,160.75,"","","","DNMT3A","","","","",26.4,27,40,40.9,45.7,42.9,0.7212355212355214,-0.47145764286425407,0.0608228798379332,1.2159330207569357,0.1897343371053066,0.7218540657065236,2503]
["Medium","Q9Y6K5","2'-5'-oligoadenylate synthase 3 [OS=Homo sapiens]",1,1,1,1,1087,121.1,8.4,2.19,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS3","ENSG00000111331","Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction","Interferon gamma signaling; OAS antiviral response; Interferon alpha/beta signaling","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease",16,13.8,19,20.3,21.8,25.2,0.725111441307578,-0.46372535704743084,0.042004143460532065,1.376707866904766,0.1509983205063694,0.82102788316294,2172]
["High","Q9Y6K8","Adenylate kinase isoenzyme 5 [OS=Homo sapiens]",8,3,3,3,562,63.3,5.07,8.18,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK5","ENSG00000154027","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors",67.5,66.4,64.9,87.3,68.3,89.5,0.8110975112199102,-0.30205272730455346,0.08488352820849253,1.0711765771553254,0.2316569689800453,0.6351546303019527,2861]
["High","Q9Y6K9","NF-kappa-B essential modulator [OS=Homo sapiens]",10,4,4,4,419,48.2,5.71,10.06,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IKBKG","ENSG00000269335","Nucleotide-binding oligomerization domain (NOD) pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","Downstream TCR signaling; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; TICAM1, RIP1-mediated IKK complex recruitment; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Ovarian tumor domain proteases; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Primary immunodeficiency; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",298,311.2,256.1,307,220.2,234.6,1.135862431084274,0.18378811476269455,0.33598946776040084,0.47367433619715343,0.5373629177126608,0.26973230661968783,4882]
["High","Q9Y6M1","Insulin-like growth factor 2 mRNA-binding protein 2 [OS=Homo sapiens]",42,22,106,19,599,66.1,8.46,221.34,"transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP2","ENSG00000073792","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",2923.7,2887.5,3036,3260.3,3145.4,3144,0.9264374797114046,-0.1102344750878408,0.016573549295067456,1.780584475636317,0.0860414048509885,1.0652925072333048,1504]
["High","Q9Y6M4-4","Isoform 4 of Casein kinase I isoform gamma-3 [OS=Homo sapiens]",13,4,6,1,424,49,9.11,8.8,"","","","CSNK1G3","","","","",12,19.4,11.8,16.2,11.2,11.4,1.1134020618556704,0.15497465997634122,0.6491757641818705,0.18763770215226083,0.7952250340025173,0.09950995663133926,6374]
["High","Q9Y6M5","zinc transporter 1 [OS=Homo sapiens]",31,10,20,10,507,55.3,6.48,52.13,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A1","ENSG00000170385","Zinc homeostasis","Zinc efflux and compartmentalization by the SLC30 family","Mineral absorption",596.5,650.4,577.4,489.9,507.5,489.5,1.226915058174726,0.29503537174571276,0.007674318868910373,2.1149601597726786,0.05605339731379999,1.2513980603228212,1069]
["High","Q9Y6M7-7","Isoform 7 of Sodium bicarbonate cotransporter 3 [OS=Homo sapiens]",12,16,29,16,1259,140.7,6.62,38.28,"","","","SLC4A7","","","","",1029.6,1052.2,932.5,970,1099.4,1050.4,0.9661837297262645,-0.04963053650866913,0.5406646802025801,0.26707200048936397,0.7167249275079364,0.1446474906178302,5890]
["Medium","Q9Y6N6","Laminin subunit gamma-3 [OS=Homo sapiens]",1,1,1,1,1575,171.1,6.58,0,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes","other molecular function","LAMC3","ENSG00000050555","Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Small cell lung cancer; Malignant pleural mesothelioma","Non-integrin membrane-ECM interactions; Laminin interactions; MET activates PTK2 signaling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer",30.5,45.1,34.5,24.7,36.7,29.6,1.2098901098901098,0.2748760184783102,0.31735577446954494,0.4984535950420256,0.5181752168670445,0.28552336216314617,4782]
["High","Q9Y6N7","Roundabout homolog 1 [OS=Homo sapiens]",9,12,16,12,1651,180.8,6.04,30.93,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ROBO1","ENSG00000169855","Development of ureteric collection system","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; SLIT2:ROBO1 increases RHOA activity","Axon guidance",610.1,661.8,626.8,580.1,538.4,510.4,1.165633249432132,0.22111393566081908,0.023817498880732514,1.6231038465193854,0.10663247205318778,0.9721105224572985,1744]
["High","Q9Y6P5","Sestrin-1 [OS=Homo sapiens]",5,2,2,2,492,56.5,6.09,4.43,"other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","SESN1","ENSG00000080546","miRNA regulation of DNA damage response; Mesodermal commitment pathway; Head and neck squamous cell carcinoma; p53 transcriptional gene network; DNA damage response","Amino acids regulate mTORC1","p53 signaling pathway; Longevity regulating pathway",65.6,68.6,68.6,62.1,61.9,63.1,1.083912346338856,0.11624809376255618,0.008007965367410197,2.0964778137474154,0.057363480356641114,1.2413645070294035,1090]
["High","Q9Y6Q1","Calpain-6 [OS=Homo sapiens]",5,3,3,3,641,74.5,7.05,6.71,"cell organization and biogenesis;protein metabolism;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CAPN6","ENSG00000077274","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",111,130.5,107.3,121.4,139.5,135.2,0.8805857106791214,-0.18346466112769336,0.15584291576441403,0.8073129348972522,0.33866448268537286,0.4702303474432663,3593]
["High","Q9Y6Q2-3","Isoform 3 of Stonin-1 [OS=Homo sapiens]",11,8,10,7,1135,127.2,5.31,16.27,"","","","STON1","","","","",398.1,391.2,392.2,503.6,496.4,487,0.7945527908540685,-0.331785018078572,4.2155803352808713E-5,4.375142630040159,7.0032449484836255E-3,2.154700683317241,47]
["High","Q9Y6Q3-1","zinc finger protein 37 homolog [OS=Homo sapiens]",15,7,7,6,630,71.2,9.09,11.29,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZFP37","ENSG00000136866","","Generic Transcription Pathway","Herpes simplex virus 1 infection",170.7,180.4,181.6,224.1,222.8,215.8,0.8038328051908858,-0.31503263851528124,5.4894300183327212E-4,3.2604727471243695,0.017008519675849956,1.7693334832472782,252]
["High","Q9Y6Q9-1","Nuclear receptor coactivator 3 [OS=Homo sapiens]",4,4,4,4,1424,155.2,7.47,2.79,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NCOA3","ENSG00000124151","Androgen receptor signaling pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway","Estrogen-dependent gene expression; MAPK6/MAPK4 signaling; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Endocrine resistance; Estrogen signaling pathway; Thyroid hormone signaling pathway; Pathways in cancer; Breast cancer",175.9,150.6,170.9,113.1,100.5,114.5,1.5160012191405057,0.6002709136984865,3.2014008133188243E-3,2.4946599490625547,0.0344304924936548,1.463056765104013,726]
["High","Q9Y6R0","Numb-like protein [OS=Homo sapiens]",10,5,9,3,609,64.9,8.85,22.59,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction","other cell component","","NUMBL","ENSG00000105245","Notch signaling; Notch signaling pathway","","Notch signaling pathway",111,99.8,110.2,104.5,103.1,93.1,1.067509145327569,0.09424842943566246,0.2543865102286043,0.59450592245999,0.4527581198689178,0.34413375220629977,4387]
["High","Q9Y6R4-1","Mitogen-activated protein kinase kinase kinase 4 [OS=Homo sapiens]",6,9,15,9,1608,181.6,6.32,20.28,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","kinase activity;other molecular function","MAP3K4","ENSG00000085511","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)","","MAPK signaling pathway; GnRH signaling pathway",441.8,465,459,436.8,422.2,450.3,1.0431528297563584,0.06095053904590988,0.1527575330214541,0.815997363939861,0.3340047095579708,0.4762474094740075,3571]
["Medium","Q9Y6V0-1","Protein piccolo [OS=Homo sapiens]",0,1,4,1,5065,552.9,6.51,8.88,"","","","","","","","",84.4,86.2,79.7,76,66.6,85,1.099736379613357,0.13715773338175027,0.2518392804999799,0.598876530090307,0.44996821559355676,0.34681816240209334,4370]
["High","Q9Y6V7","Probable ATP-dependent RNA helicase ddx49 [OS=Homo sapiens]",14,4,9,4,483,54.2,9.06,20.08,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX49","ENSG00000105671","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",273.2,305.9,264.2,255.4,298.1,279.8,1.0120004800192006,0.0172099743416658,0.8598338986548344,0.06558543697136146,0.9249907799251788,0.03386259617726372,7258]
["High","Q9Y6W3","Calpain-7 [OS=Homo sapiens]",18,11,17,11,813,92.6,7.65,31.21,"protein metabolism;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CAPN7","ENSG00000131375","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",500.9,480.8,473.7,519.5,526,485.8,0.9504342715339908,-0.07334123593651311,0.1644173652857038,0.7840523154487645,0.34913537888245183,0.4570061406589915,3677]
["High","Q9Y6W5","Wiskott-Aldrich syndrome protein family member 2 [OS=Homo sapiens]",17,10,22,10,498,54.3,5.53,38.22,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","WASF2","ENSG00000158195","Regulation of actin cytoskeleton","RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs","Adherens junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Choline metabolism in cancer",964.2,942.8,953.6,1081.8,1048,977.5,0.9206063141634216,-0.1193437572777504,0.05855246649445466,1.2324548057603728,0.18584457658077316,0.7308501082051165,2460]
["High","Q9Y6X2","E3 SUMO-protein ligase PIAS3 [OS=Homo sapiens]",3,2,2,2,628,68,7.69,5.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","PIAS3","ENSG00000131788","Androgen receptor signaling pathway; Prolactin signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; EGF/EGFR signaling pathway; Regulatory circuits of the STAT3 signaling pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Interferon type I signaling pathways","SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMOylation of immune response proteins; SUMOylation of DNA replication proteins","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway",46.3,66.5,45.6,46.9,54.5,55,1.0127877237851663,0.018331822772257495,0.931968930893581,0.03059856550694544,0.9652226306429341,0.015372504160548469,7539]
["High","Q9Y6X3-1","MAU2 chromatid cohesion factor homolog [OS=Homo sapiens]",5,2,2,2,613,69,7.25,5.55,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MAU2","ENSANAG00000026794; ENSCANG00000033671; ENSCATG00000015302; ENSCCAG00000031923; ENSCSAG00000005122; ENSG00000129933; ENSGGOG00000002989; ENSMFAG00000041829; ENSMNEG00000034232; ENSPPAG00000032359; ENSPTRG00000010738; ENSRBIG00000036077; ENSRROG00000032649; ENSSBOG00000034577","Cohesin complex - Cornelia de Lange syndrome","Cohesin Loading onto Chromatin","",85.8,76.1,84.5,117.6,90.3,96.8,0.8086642599277978,-0.3063872439915843,0.09119687530846302,1.0400200417104002,0.24162375378638587,0.61686037290169,2947]
["High","Q9Y6X4-1","Soluble lamin-associated protein of 75 kDa [OS=Homo sapiens]",13,6,9,6,670,74.9,4.6,21.39,"","other membranes;nucleus","","FAM169A","ENSG00000198780","","RHOF GTPase cycle","",312.6,297.8,335,419.5,423.6,400.4,0.7602734217933255,-0.395409737745619,1.5567480901642456E-3,2.8077816584035036,0.026083882163095342,1.5836277704348685,466]
["High","Q9Y6X5","Bis(5'-adenosyl)-triphosphatase ENPP4 [OS=Homo sapiens]",5,2,2,2,453,51.6,6.15,2.38,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes","other molecular function","ENPP4","ENSG00000001561","","Neutrophil degranulation","Purine metabolism; Metabolic pathways",11.7,11.7,15.8,12.6,11.3,16.5,0.9702970297029704,-0.0435016386365864,0.8565836905631752,0.0672301988699269,0.9236577069351294,0.03448894169185717,7241]
["High","Q9Y6X8","Zinc fingers and homeoboxes protein 2 [OS=Homo sapiens]",2,2,2,2,837,92.3,6.86,3.13,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZHX2","ENSG00000178764","","","",45.9,50,54.6,55.2,62.4,55.6,0.8689376443418014,-0.20267544307966046,0.09210299444204037,1.035726249841002,0.24278871728678297,0.6147714993675564,2962]
["High","Q9Y6X9-1","MORC family CW-type zinc finger protein 2 [OS=Homo sapiens]",23,18,39,18,1032,117.8,8.38,66.76,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","MORC2","ENSG00000133422","","Fatty acyl-CoA biosynthesis","",1823.3,1793.2,1813.4,1677,1681.6,1743.3,1.0642897743977733,0.08989100720129194,0.00913459346263596,2.0393107762657605,0.06175143355520483,1.2093529558352882,1155]
["High","Q9Y6Y0","influenza virus NS1A-binding protein [OS=Homo sapiens]",10,5,7,5,642,71.7,5.53,11.53,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","IVNS1ABP","ENSG00000116679","","","",243,277.7,272.8,522.2,624.7,581.2,0.4591748162722064,-1.1228845762089494,5.9521150412310383E-4,3.225328683428407,0.017738211542722114,1.7510901700895172,262]
["High","Q9Y6Y8","SEC23-interacting protein [OS=Homo sapiens]",14,16,38,16,1000,111,5.54,49.87,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC23IP","ENSG00000107651","","COPII-mediated vesicle transport","",1180,1172.4,1169.2,1283.9,1198.4,1250.3,0.9434710389540804,-0.08394986174483816,0.048566673690591915,1.313661640140096,0.16523250029461511,0.7819045253547406,2295]

{"sheet":"Cl-P","index":4,"n_rows":7809,"n_cols":32,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["Protein FDR Confidence: Combined","Accession","Description","Coverage [%]","# Peptides","# PSMs","# Unique Peptides","# AAs","MW [kDa]","calc. pI","Score Sequest HT: Sequest HT","Biological Process","Cellular Component","Molecular Function","Gene Symbol","Ensembl Gene ID","WikiPathways","Reactome Pathways","KEGG Pathways","Abundances (Normalized): F19: 132C, Sample, CI-P","Abundances (Normalized): F19: 133C, Sample, CI-P","Abundances (Normalized): F19: 134C, Sample, CI-P","Abundances (Normalized): F19: 126, Sample, DMSO","Abundances (Normalized): F19: 127C, Sample, DMSO","Abundances (Normalized): F19: 128C, Sample, DMSO","Ratio","log2(Ratio)","P-Value","− log10(P-Value)","q-Value","− log10(q-Value)","Rank (P-Value)"]
["Medium","A0A0B4J2F0","Protein PIGBOS1 [OS=Homo sapiens]",19,1,1,1,54,6.3,8.5,0,"stress response;other biological processes","other membranes;mitochondrion","","PIGBOS1","ENSG00000225973","","","",58.4,57.7,53.7,51.5,54.7,56.6,{"$f":"AVERAGE(T2:V2)/AVERAGE(W2:Y2)","v":1.0429975429975429},{"$f":"LOG(Z2,2)","v":0.060735759286791306},{"$f":"TTEST(T2:V2,W2:Y2,2,2)","v":0.3262725985140202},{"$f":"-LOG10(AB2)","v":0.4864193982129142},{"$f":"AB2*7808/AF2","v":0.5589154122855352},{"$f":"-LOG10(AD2)","v":0.2526539143986356},4558]
["High","A0AV96","RNA-binding protein 47 [OS=Homo sapiens]",13,6,11,6,593,64.1,7.68,29.14,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","RBM47","ENSG00000163694","TYROBP causal network in microglia","","",230.1,252.5,242,338,389.1,365.5,0.6631887241442431,-0.5925086172447068,1.6010506052943922E-3,2.795594940877217,0.03272513907366129,1.4851184991302901,382]
["High","A0AVF1","intraflagellar transport protein 56 [OS=Homo sapiens]",10,4,5,4,554,64.1,6.93,8.28,"cell organization and biogenesis;transport;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","TTC26","ENSG00000105948","Ciliary landscape; Genes related to primary cilium development (based on CRISPR)","Intraflagellar transport","",160.1,135.3,173.5,164.5,182.6,155.9,0.9322067594433399,-0.101278120972069,0.4527345176671257,0.3441563924919884,0.6693715421217415,0.17433275532184783,5281]
["High","A0AVT1-1","Ubiquitin-like modifier-activating enzyme 6 [OS=Homo sapiens]",33,26,66,26,1052,117.9,6.14,133.34,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBA6; UBE1L2","ENSG00000033178","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",1997.3,2211.2,2095.1,2226.3,2165.4,2198.9,0.956453130215762,-0.06423382204210958,0.21091187525415384,0.675898966907471,0.43485606601120497,0.3616544673696619,3787]
["High","A0FGR8-2","Isoform 2 of Extended synaptotagmin-2 [OS=Homo sapiens]",17,12,21,12,893,98.8,8.68,40.11,"","","","ESYT2","","","","",736.1,655.3,712.8,655.7,659.6,616.4,1.0892995806802297,0.12340078061464824,0.10645868081278984,0.9728189197082161,0.29268640133319124,0.5335974550966184,2840]
["High","A0JLT2","Mediator of RNA polymerase II transcription subunit 19 [OS=Homo sapiens]",11,1,1,1,244,26.3,9.82,3.66,"other biological processes","nucleus","other molecular function","MED19","ENSG00000156603","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",32,41.6,32.4,28.4,27.5,26.2,1.2911084043848966,0.36861013767275685,0.06750476872322599,1.1706655463240951,0.22277144302237892,0.6521404819573712,2366]
["High","A0JNW5-1","UHRF1-binding protein 1-like [OS=Homo sapiens]",16,14,18,14,1464,164.1,6.32,42.2,"","cytosol;other cytoplasmic organelle","other molecular function","UHRF1BP1L","ENSG00000111647","","RND2 GTPase cycle","",595,653.9,622.3,616.9,586.5,595.9,1.0399599844383927,0.056528017440457025,0.2809720627063395,0.5513368602218026,0.5111439575049158,0.2914567688570808,4292]
["High","A0MZ66","Shootin-1 [OS=Homo sapiens]",29,17,34,17,631,71.6,5.33,61.53,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SHTN1","ENSG00000187164","","Recycling pathway of L1","",1202.1,1187.4,1132.5,1363.7,1291.1,1246.9,0.9026834456775251,-0.14770794485391536,0.03430060847601496,1.4646981757172368,0.15445164416420118,0.8112074641987927,1734]
["Medium","A0PJW6","Transmembrane protein 223 [OS=Homo sapiens]",4,1,1,1,202,22,11.02,0,"developmental processes","other membranes","","TMEM223","ENSG00000168569","","","",73.9,95.2,61.9,72.8,60.3,73.5,1.11810261374637,0.16105259743836076,0.487205693089934,0.31228764553302674,0.6967219874809898,0.15694048357912863,5460]
["Medium","A0PJZ3","Glucoside xylosyltransferase 2 [OS=Homo sapiens]",2,1,1,1,443,51,9.77,0,"protein metabolism;other metabolic processes","other membranes","other molecular function","GXYLT2","ENSG00000172986","Vitamin D receptor pathway","","Other types of O-glycan biosynthesis",28.6,33.4,37.8,23.5,27.1,26.6,1.2927461139896372,0.37043896806918003,0.059367448038327345,1.2264516192008204,0.20684561993898257,0.6843536710772461,2241]
["High","A0PK00","Transmembrane protein 120B [OS=Homo sapiens]",9,2,3,2,339,40.2,8.9,8.9,"cell organization and biogenesis;transport;other biological processes","other membranes;nucleus","","TMEM120B","ENSG00000188735","","","",118.2,102.3,128.4,105,131.5,116.9,0.9872665534804754,-0.01848844235724226,0.896140847997043,0.04762372616310618,0.9467010879665689,0.02378712378300751,7391]
["Medium","A1A5C7-1","Solute carrier family 22 member 23 [OS=Homo sapiens]",1,1,1,1,686,73.7,7.74,2.24,"transport","other membranes","transporter activity","SLC22A23","ENSG00000137266","","","",91.7,104.7,91.3,128.9,96.6,105.7,0.8686594202898551,-0.2031374517600382,0.24222969264333127,0.6157726218834697,0.4727141814944091,0.32540136860383145,4001]
["High","A1L020","RNA-binding protein MEX3A [OS=Homo sapiens]",22,8,18,8,520,54.1,7.27,58.94,"","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MEX3A","ENSG00000254726","","","",506.9,518.9,445.4,630.8,595.1,607.7,0.8023560209424082,-0.3176855643449675,0.008508846476731061,2.070129312153539,0.07357372457399348,1.1332772578084098,903]
["High","A1L0T0","Acetolactate synthase-like protein [OS=Homo sapiens]",22,11,18,11,632,67.8,8.15,54.07,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ILVBL","ENSG00000105135","","","",817.7,739,853,718.7,838.7,802.7,1.0210160586415826,0.030005557244491717,0.7526844186977393,0.12338707419242115,0.8745476102964208,0.058216542587611025,6720]
["High","A1L170","Uncharacterized protein C1orf226 [OS=Homo sapiens]",8,1,1,1,272,29,5.27,3.81,"","","","C1orf226","ENSG00000239887","","","",30.2,45.8,38.9,37.7,32.4,29.6,1.1524573721163494,0.20471338824791777,0.37672535998478274,0.42397514345285175,0.6068643719333987,0.2169083585169756,4847]
["High","A1X283","SH3 and PX domain-containing protein 2B [OS=Homo sapiens]",22,17,37,17,911,101.5,8.69,68.96,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytoskeleton;other cell component","enzyme regulator activity;other molecular function","SH3PXD2B","ENSG00000174705","","","",1761.7,1691.7,1734.6,1822.6,1692.6,1699.3,0.9949180170677916,-0.007350444851867319,0.8598279707232906,0.06558843112736898,0.9314007762773937,0.030863404439740116,7208]
["High","A2AJT9-1","BCLAF1 and THRAP3 family member 3 [OS=Homo sapiens]",9,6,7,6,711,83.8,9.7,7.11,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","BCLAF3","ENSG00000173681","","","",320.9,310.2,329,357.1,344.1,359.4,0.9052423156703753,-0.14362406973801708,0.00979992138030163,2.0087774084134367,0.07995588938076817,1.097149541531645,957]
["High","A2RRP1-1","neuroblastoma-amplified sequence [OS=Homo sapiens]",8,15,28,15,2371,268.4,5.96,49.89,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","NBAS","ENSG00000151779","","COPI-dependent Golgi-to-ER retrograde traffic","",1117.9,1106.1,1174.4,1131.1,1232.1,1154.8,0.9660034110289937,-0.049899811555169836,0.34271165389053054,0.46507112715958193,0.575337044415666,0.24007766201246294,4651]
["High","A2RTX5","Probable threonine--tRNA ligase 2, cytoplasmic [OS=Homo sapiens]",7,4,5,4,802,92.6,6.05,12.01,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","TARS3","ENSG00000185418","","","Aminoacyl-tRNA biosynthesis",128.6,133.6,125,135.7,126.2,131.5,0.9842399593289274,-0.022918005003935572,0.607290340320864,0.21660362679561526,0.7820753714704448,0.10675139037194624,6063]
["High","A2RU67","Protein FAM234B [OS=Homo sapiens]",2,1,2,1,622,67,5.02,6.52,"","other membranes;cytoskeleton;ER/Golgi","","FAM234B","ENSG00000084444","","","",75.1,68,65.2,84.8,85.6,90.6,0.7980842911877395,-0.3253869674166,0.00709822879553172,2.1488500062513882,0.06677466317531527,1.1753882939688267,830]
["Medium","A2RUB1","Meiosis-specific coiled-coil domain-containing protein MEIOC [OS=Homo sapiens]",1,1,1,1,952,107.5,7.12,1.86,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","MEIOC","ENSG00000180336","","","",23.1,24.1,15.9,34.2,28.7,27.7,0.6964679911699779,-0.5218710450636861,0.04904958213975712,1.309364688083639,0.18681909138888955,0.7285787444807579,2050]
["High","A2RUC4","tRNA wybutosine-synthesizing protein 5 [OS=Homo sapiens]",18,5,6,5,315,36.5,7.55,9.39,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TYW5","ENSG00000162971","","Synthesis of wybutosine at G37 of tRNA(Phe)","",173.4,180.4,190,180.7,191.2,169.2,1.0049898355202367,0.007180910042308719,0.9155259072619244,0.03832936166081068,0.9561832910515122,0.019458849708969744,7476]
["High","A2VDJ0","Transmembrane protein 131-like [OS=Homo sapiens]",1,1,1,1,1609,179.2,6.86,2.49,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","TMEM131L","ENSG00000121210","","","",48,38.9,62.6,50.6,64.3,55.7,0.876318874560375,-0.19047216223282296,0.42772246543304315,0.3688379385265078,0.6508783882481389,0.1865001485232572,5131]
["High","A3KMH1","von Willebrand factor A domain-containing protein 8 [OS=Homo sapiens]",12,16,18,16,1905,214.7,7.4,32.67,"","mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","VWA8","ENSG00000102763","","","",445.9,454,464.2,498.2,526.8,507.2,0.8902884740895444,-0.1676552164430191,0.004919713415306333,2.3080601951546096,0.055590625682651,1.2549984378701726,691]
["High","A3KN83-1","protein strawberry notch homolog 1 [OS=Homo sapiens]",21,17,54,17,1393,154.2,7.88,87.98,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SBNO1","ENSG00000139697","","","",985.7,1033.4,965.3,951.9,922.4,922.1,1.0672292948076099,0.09387017329705809,0.04936127523630258,1.3066136289396595,0.18764013488074516,0.7266742635422834,2054]
["High","A4D1E9-1","GTP-binding protein 10 [OS=Homo sapiens]",13,5,13,5,387,42.9,9.03,25.82,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","GTPBP10","ENSG00000105793","","","",833.4,909.8,910.2,844.2,903.5,917.3,0.9956472795497184,-6.2933547729426215E-3,0.9148899611517811,0.03863113777879774,0.9559026919139713,0.019586315376331265,7473]
["Medium","A4D1F6","Leucine-rich repeat and death domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,860,98,7.46,0,"signal transduction;other biological processes","","","LRRD1","ENSG00000240720","","","",15.3,11.5,16.8,17.4,16.8,18.8,0.8226415094339622,-0.28166422467363533,0.1364549311527529,0.8650107653533086,0.3378059931644561,0.4713326496875572,3154]
["High","A4D1P6-1","WD repeat-containing protein 91 [OS=Homo sapiens]",3,1,1,1,747,83.3,6.58,4.28,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle","enzyme regulator activity","WDR91","ENSG00000105875","","CDC42 GTPase cycle","",31.2,20.4,22,29,30.9,35.5,0.771488469601677,-0.3742834999484989,0.13432305325084243,0.8718494449602244,0.3349710634885269,0.47499270791850423,3131]
["High","A4D1S0-1","killer cell lectin-like receptor subfamily G member 2 [OS=Homo sapiens]",21,8,17,8,409,42.8,5.87,31.59,"","other membranes","other molecular function","KLRG2","ENSG00000188883","","","",784.3,775.8,716.9,739.8,625.8,634.6,1.1383861613838617,0.18699002918344104,0.09467533911530708,1.0237631306154507,0.2733820443092891,0.5632300132264134,2704]
["High","A5A3E0","POTE ankyrin domain family member F [OS=Homo sapiens]",11,10,366,1,1075,121.4,6.2,713.12,"","other cell component","","POTEF","ENSG00000196604","","","",35.4,37.3,39.2,28.7,33.4,31.7,1.1929637526652452,0.25455020846101745,0.02649611504285891,1.5768177992381207,0.13261645272733485,0.8774025929339468,1560]
["High","A5LHX3","proteasome subunit beta type-11 [OS=Homo sapiens]",5,1,1,1,300,32.5,6.46,2.96,"protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","other molecular function","PSMB11","ENSG00000222028","","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling","Proteasome",38.5,33.5,26.9,37,30,28.3,1.037775445960126,0.0534943068491691,0.7933874076477072,0.10051469676899459,0.8948098915084931,0.048269223721795436,6923]
["High","A5PLN9-1","Trafficking protein particle complex subunit 13 [OS=Homo sapiens]",16,4,6,4,417,46.5,5.6,10.22,"","cytosol;ER/Golgi","","C5orf44; TRAPPC13","ENSG00000113597","","RAB GEFs exchange GTP for GDP on RABs","",144.7,122.1,156.1,145.9,151.6,136.6,0.9741994932043307,-0.03771086222407917,0.7493283274429939,0.12532784911865302,0.8732471015932682,0.058862847160844015,6700]
["High","A5YKK6","CCR4-NOT transcription complex subunit 1 [OS=Homo sapiens]",22,46,128,46,2376,266.8,7.11,215.71,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","CNOT1","ENSG00000125107","Ciliary landscape","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",4208.3,4125.7,4499.4,4511.5,4713.7,4706.3,0.9211786239816244,-0.11844716121373923,0.04937625546335245,1.3064818486541037,0.1875144954561556,0.7269651543187065,2056]
["High","A6H8Y1","Transcription factor TFIIIB component B'' homolog [OS=Homo sapiens]",1,3,4,3,2624,293.7,5.11,5.2,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","BDP1","ENSG00000145734; ENSG00000273873","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter","",263.4,234.1,326.2,330,343.8,316.3,0.831936168063832,-0.26545525588465274,0.12159057953614914,0.9151000715596017,0.31730589739914855,0.49852185609339006,2992]
["Medium","A6NCS6","Uncharacterized protein C2orf72 [OS=Homo sapiens]",5,2,2,2,295,30.5,8.34,2.29,"","","","C2orf72","ENSG00000204128","","","",150.7,119.9,140.8,133.6,127.6,129.3,1.0535211267605635,0.07521924549559246,0.49335377372679207,0.3068415454743247,0.7016587004114376,0.1538740852657812,5490]
["High","A6ND36-1","Protein FAM83G [OS=Homo sapiens]",4,3,4,3,823,90.8,6.39,4.73,"signal transduction","cytosol;nucleus","other molecular function","FAM83G","ENSG00000188522","","","",116.5,77.5,120.7,124.5,118.9,103.5,0.907177861055059,-0.1405426619879586,0.5169410313570773,0.2865589950431035,0.719094169398906,0.14321423260414046,5613]
["High","A6NDB9","Paralemmin-3 [OS=Homo sapiens]",9,6,8,6,673,71.7,4.53,23.73,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PALM3","ENSG00000187867; ENSG00000288318","","","",315.4,302.1,297,368.5,301.4,306.7,0.9364120417775957,-0.09478460800138479,0.40438107787368294,0.3932091744640948,0.6304727348318123,0.20033369000783272,5008]
["High","A6NDG6","glycerol-3-phosphate phosphatase [OS=Homo sapiens]",46,10,23,10,321,34,6.14,47.54,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","PGP","ENSG00000184207","","Glycolysis","Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism",994.5,964.2,908.1,1068.3,979.5,1018.4,0.9349683647511579,-0.09701054356488763,0.13916061538336533,0.8564836594228038,0.3414726853907343,0.46664403007473115,3182]
["High","A6NDU8","UPF0600 protein C5orf51 [OS=Homo sapiens]",45,9,22,9,294,33.6,5.26,31.35,"","cytosol;nucleus","","C5orf51","ENSG00000205765","","","",606.4,563.8,642.9,624.8,622.6,610.4,0.9759392830229302,-0.03513669997471948,0.5571564070337296,0.25402287093674353,0.7506949484243935,0.12453650657772296,5795]
["High","A6NED2","RCC1 domain-containing protein 1 [OS=Homo sapiens]",8,2,3,2,376,40.1,5.27,11.52,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;other cell component","","RCCD1","ENSG00000166965","","","",141.7,158.2,144.4,157.9,145.6,173,0.932423924449108,-0.10094207278730041,0.31849790847717824,0.49689341525893754,0.5511595011945496,0.258722701575588,4512]
["High","A6NFI3","Zinc finger protein 316 [OS=Homo sapiens]",2,2,4,2,1004,108.4,5.31,7.23,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF316","ENSG00000205903","","","Herpes simplex virus 1 infection",318.2,305.3,284.3,385.8,341.7,377.7,0.8213897937024971,-0.28386107387459875,0.01719913349114573,1.7644934327141635,0.10803767843834744,0.9664247566971728,1243]
["High","A6NGB9","WAS/WASL-interacting protein family member 3 [OS=Homo sapiens]",4,1,1,1,483,49.4,10.15,2.69,"other biological processes","cytosol;cytoskeleton","cytoskeletal activity","WIPF3","ENSG00000122574","","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs","Endocytosis; Pathogenic Escherichia coli infection; Yersinia infection",15.1,19.1,21.5,15.5,22.9,23.3,0.9027552674230146,-0.14759316180938614,0.5598513543958452,0.2519272668062673,0.7525080693962402,0.1234888386238607,5809]
["High","A6NHQ2","rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 [OS=Homo sapiens]",10,4,13,1,334,34.8,10.35,37.65,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","FBLL1","ENSG00000188573","","","",25.3,19,27.9,24.6,22.7,26.4,0.9796472184531886,-0.029665782207898728,0.8692557987970276,0.06085240346075147,0.9340970653739598,0.029607992328811963,7266]
["High","A6NHR9-1","structural maintenance of chromosomes flexible hinge domain-containing protein 1 [OS=Homo sapiens]",19,31,63,31,2005,226.2,7.3,124.61,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMCHD1","ENSG00000101596","","","",2687.1,2736.1,2766,2816.1,2908,2852.8,0.9547971877951239,-0.06673377769264513,0.021453054662585184,1.668510860651631,0.11939091290482189,0.9230287270213555,1403]
["Medium","A6NHX0","Cytosolic arginine sensor for mTORC1 subunit 2 [OS=Homo sapiens]",6,1,2,1,329,36,5.16,0,"other biological processes","cytosol","other molecular function","CASTOR2","ENSG00000274070","","Amino acids regulate mTORC1","mTOR signaling pathway",15.1,15,16.3,15.8,14.1,21,0.9115913555992143,-0.13354085094812287,0.5177362606281979,0.2858914173259269,0.7195594024537147,0.14293334753285075,5618]
["Medium","A6NHY2","ankyrin repeat and death domain-containing protein 1B [OS=Homo sapiens]",1,1,1,1,528,59.1,8.35,2.29,"signal transduction","","","ANKDD1B","ENSG00000189045","","","",218.2,112.7,214.6,230.6,219.8,166.3,0.8845467812550672,-0.17698964976704823,0.5838778491793524,0.23367800044943746,0.7677531570212839,0.11477838905082786,5938]
["High","A6NI28","Rho GTPase-activating protein 42 [OS=Homo sapiens]",2,2,3,1,874,98.5,7.99,7.83,"signal transduction;other biological processes","","enzyme regulator activity","ARHGAP42","ENSG00000165895","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",62.7,52.6,70.5,68.6,60.9,74.4,0.9112309955860717,-0.1341112736339435,0.40526074262939255,0.3922654640727113,0.6309622888235886,0.19999659677051282,5015]
["High","A6NIH7","Protein unc-119 homolog B [OS=Homo sapiens]",69,10,32,9,251,28.1,5.68,106.26,"cell organization and biogenesis;transport;developmental processes","cytosol;other cell component","other molecular function","UNC119B","ENSG00000175970","","Trafficking of myristoylated proteins to the cilium","",993.1,1090.7,987,873.3,874.4,864,1.1757858865872803,0.23362536588621852,0.010550925208667837,1.976709455494148,0.08329790093961423,1.0793659424326922,989]
["High","A6NJ78","Probable methyltransferase-like protein 15 [OS=Homo sapiens]",7,2,3,2,407,46.1,8.62,8.59,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","METTL15","ENSG00000169519","","","",42,40.9,43.8,41.9,38.9,39.7,1.0514522821576764,0.07238337802348556,0.16886782075159562,0.7724531011778637,0.3808549810596356,0.41924036005860343,3462]
["High","A6NK58","Putative lipoyltransferase 2, mitochondrial [OS=Homo sapiens]",10,2,2,2,231,25.2,8.27,0,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","LIPT2","ENSG00000175536","","Glyoxylate metabolism and glycine degradation","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors",30.5,26.3,33.3,38.3,35.6,38.1,0.8044642857142856,-0.31389972113142806,0.029921520961195824,1.5240163343280995,0.14245563150305915,0.846320377717162,1640]
["High","A6NKD9","Coiled-coil domain-containing protein 85C [OS=Homo sapiens]",8,3,3,3,419,45.2,6.96,1.63,"developmental processes","other cell component","","CCDC85C","ENSG00000205476","","","",58.5,48.3,36.3,36.1,30.1,29.8,1.4906249999999999,0.5759173611181491,0.0801769616023378,1.0959504058597715,0.24812592793937913,0.6053278517187106,2523]
["High","A6NKF1","SAC3 domain-containing protein 1 [OS=Homo sapiens]",7,2,5,2,404,43.5,8.69,17.18,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","","SAC3D1","","","","",144.5,161.7,156.3,162.5,160.7,152.5,0.9722514189615303,-0.040598659671417736,0.4998541668871771,0.3011566831724687,0.705633942335035,0.1514205369829989,5531]
["Medium","A6NMB9","Putative fidgetin-like protein 2 [OS=Homo sapiens]",1,1,1,1,653,66.6,6.73,1.79,"cell organization and biogenesis","nucleus","other molecular function","FIGNL2","ENSG00000261308","","","",32.9,23.1,29.2,34.6,36.3,30.8,0.8377581120943953,-0.2553943436316618,0.1696267159380183,0.7705057460019585,0.3821250427132276,0.4177944997212214,3466]
["High","A6ZKI3","Retrotransposon Gag-like protein 8B [OS=Homo sapiens]",29,3,6,3,113,13.2,5.07,9.43,"","","","RTL8C","ENSG00000134590","","","",67.6,88,85.8,66.4,76.8,65.7,1.1555768310196266,0.2086131836879132,0.21674883001452397,0.6640432381175307,0.4417579913216923,0.35481558544197306,3831]
["High","A7E2V4","Zinc finger SWIM domain-containing protein 8 [OS=Homo sapiens]",2,2,2,2,1837,197.2,6.8,3.1,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","ZSWIM8","ENSG00000214655","","Regulation of expression of SLITs and ROBOs","",42.9,54.2,54,55.7,57.9,55.5,0.8935541099940864,-0.16237299924515414,0.19061703718495526,0.7198382850999047,0.4069832721739488,0.39042344077931357,3657]
["High","A8CG34-1","Nuclear envelope pore membrane protein POM 121C [OS=Homo sapiens]",5,6,12,1,1229,125,10.37,18.15,"","","","","","","","",116.8,127.1,115.2,106.6,91.1,101.4,1.2006018054162486,0.26375774254530593,0.027332390440629368,1.5633223840491703,0.13524163787099752,0.8688895782639365,1578]
["Low","A8K2U0","Alpha-2-macroglobulin-like protein 1 [OS=Homo sapiens]",0,1,1,1,1454,161,5.73,0,"other biological processes","non-structural extracellular","enzyme regulator activity;other molecular function","A2ML1","ENSG00000166535","","","",65.5,68.8,76.9,59.4,81.7,72.8,0.9873772791023844,-0.018326647806590702,0.9079830392785356,0.04192226383192917,0.95327841477569,0.02078024066077763,7437]
["High","A8MQ14","Zinc finger protein 850 [OS=Homo sapiens]",8,4,5,4,1090,125.4,8.7,12.46,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF850","ENSG00000267041","","","Herpes simplex virus 1 infection",374.5,360.2,393.9,385.4,376.8,402.6,0.9689217032967031,-0.04554800595434522,0.38437710259715074,0.4152424912217303,0.6133693883258846,0.21227790232303304,4893]
["Medium","A8MW92","PHD finger protein 20-like protein 1 [OS=Homo sapiens]",1,1,1,1,1017,114.9,6.83,2.1,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF20L1","ENSG00000129292","","","",81.4,81.9,78.4,111.4,100,86.7,0.8108017443810802,-0.30257890222558614,0.05981486978729903,1.2231908383560386,0.20794056246626486,0.6820607856228421,2246]
["High","A9UHW6","MIF4G domain-containing protein [OS=Homo sapiens]",18,4,5,4,222,25.4,5.33,10.69,"other biological processes","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","MIF4GD","ENSG00000125457","","","",129.6,114.5,120.2,138.3,125.2,140.4,0.9019559296855658,-0.1488711509603044,0.11133382036776203,0.9533728880646647,0.30121083486884476,0.5211294101635047,2886]
["Medium","B0YJ81","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 [OS=Homo sapiens]",4,1,1,1,288,32.4,9.04,2.63,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","HACD1","ENSG00000165996","","Synthesis of very long-chain fatty acyl-CoAs","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism",35.9,41.7,35,31,33.8,37.3,1.1028403525954946,0.1412239612024281,0.276509969533817,0.5582892056414916,0.5076392763037957,0.2944447836968796,4253]
["High","B2RTY4","unconventional myosin-IXa [OS=Homo sapiens]",4,9,9,8,2548,292.5,8.88,12.24,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","MYO9A","ENSG00000066933","","RHOA GTPase cycle; RHOB GTPase cycle; RHOV GTPase cycle","",331.8,337.2,352.5,299.2,278.4,285.3,1.1837988179395065,0.24342392131943894,3.7198010516821508E-3,2.4294802871253967,0.048568907377147544,1.313641666455172,598]
["High","L0R6Q1","SLC35A4 upstream open reading frame protein [OS=Homo sapiens]",22,1,1,1,103,11.1,8.1,3.21,"stress response","other membranes","","SLC35A4","ENSG00000176087","","","",20.6,19.6,15.7,16.7,21.4,17.9,0.998214285714286,-2.5785441017758654E-3,0.9878340603979887,5.3160034955096365E-3,0.9929207445400998,3.0854157368227103E-3,7768]
["High","O00115","Deoxyribonuclease-2-alpha [OS=Homo sapiens]",4,2,5,2,360,39.6,8.05,8.52,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","other cytoplasmic organelle","nucleic acid binding activity;other molecular function","DNASE2","ENSG00000105612","","Lysosome Vesicle Biogenesis","Lysosome",574.4,574.9,596.6,638,611.3,621.6,0.9331872360895827,-0.09976152026584482,0.017504168288598,1.756858519932007,0.10916337539726294,0.9619230441477825,1252]
["High","O00116","Alkyldihydroxyacetonephosphate synthase, peroxisomal [OS=Homo sapiens]",39,18,47,18,658,72.9,7.34,100.26,"other metabolic processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","AGPS","ENSG00000018510","Triacylglyceride synthesis","Plasmalogen biosynthesis; TYSND1 cleaves peroxisomal proteins","Ether lipid metabolism; Metabolic pathways; Peroxisome",1352.1,1397.5,1431.2,1369.3,1490.7,1442.4,{"$f":"AVERAGE(T66:V66)/AVERAGE(W66:Y66)","v":0.971736705094831},{"$f":"LOG(Z66,2)","v":-0.041362630552851914},{"$f":"TTEST(T66:V66,W66:Y66,2,2)","v":0.38993900108365076},{"$f":"-LOG10(AB66)","v":0.4090033251907377},{"$f":"AB66*7808/AF66","v":0.6197117281622523},{"$f":"-LOG10(AD66)","v":0.20781028466692403},4913]
["High","O00139-2","Isoform 2 of Kinesin-like protein KIF2A [OS=Homo sapiens]",40,19,66,16,660,75,6.4,111.99,"","","","KIF2A","","","","",1845.8,1808.5,1839.4,1959.8,1793.9,1872.5,0.976449468557819,-0.03438270858107423,0.42076697485530157,0.37595835440791553,0.6450713802611809,0.19039222592545832,5093]
["High","O00148","ATP-dependent RNA helicase DDX39A [OS=Homo sapiens]",49,19,142,7,427,49.1,5.68,236.83,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","other molecular function","DDX39A","ENSG00000123136","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",1655.5,1618.1,1933.1,1771.5,2006.7,1870.1,0.9218171839314485,-0.1174474331559426,0.2889549241164579,0.5391699002687715,0.5212939111601902,0.2829173477086492,4328]
["High","O00151","PDZ and LIM domain protein 1 [OS=Homo sapiens]",33,10,31,9,329,36,7.02,72.73,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PDLIM1","ENSG00000107438","","","",1529.4,1275.1,1259.8,1644.4,1293.6,1403.2,0.9362157928683313,-0.09508699304978994,0.533357429908521,0.27298165061392454,0.7313759769451584,0.1358593087662254,5694]
["High","O00154","cytosolic acyl coenzyme A thioester hydrolase [OS=Homo sapiens]",47,16,63,16,380,41.8,8.54,116.69,"other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","ACOT7","ENSG00000097021","","Mitochondrial Fatty Acid Beta-Oxidation","Fatty acid elongation; Biosynthesis of unsaturated fatty acids",2301.1,2159.8,2298.8,2074.2,2321.5,2140.6,1.0341783577865153,0.04848501902234761,0.44234015408994204,0.35424363510891377,0.6612659243986727,0.17962385628727198,5223]
["High","O00159-3","Isoform 3 of Unconventional myosin-Ic [OS=Homo sapiens]",19,17,24,17,1044,119.6,9.45,43.63,"","","","MYO1C","","","","",1247.9,1273.4,1268.2,1322.1,1346.8,1310.5,0.952279238076092,-0.0705434159792198,8.751641095694259E-3,2.0579105010375622,0.07492633078418945,1.125365534707343,912]
["High","O00161","Synaptosomal-associated protein 23 [OS=Homo sapiens]",67,13,35,13,211,23.3,5.01,82.87,"cell-cell signaling;cell organization and biogenesis;stress response;transport","plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP23","ENSG00000092531","Insulin signaling","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding","SNARE interactions in vesicular transport; Platelet activation",1456.3,1467,1449.8,1392.4,1305.7,1306.3,1.0920737189091998,0.1270702466561223,0.013651365816458448,1.864823895372155,0.09594047191260806,1.0179981496543873,1111]
["High","O00165","HCLS1-associated protein X-1 [OS=Homo sapiens]",28,6,14,6,279,31.6,4.92,39.84,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HAX1","ENSG00000143575","","","",550.5,647.9,548.3,746.6,682.2,698.6,0.8210491679984958,-0.284459475437721,0.02909178928179646,1.5362295667792938,0.13969784176646172,0.8548103033787077,1626]
["High","O00170","AH receptor-interacting protein [OS=Homo sapiens]",32,8,21,8,330,37.6,6.29,43.43,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","AIP","ENSG00000110711","Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway","Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Cushing syndrome; Chemical carcinogenesis",705.6,661.6,640.8,851.4,767.7,742,0.8504510609461693,-0.2336998762375961,0.036755371375748074,1.4346791847869607,0.15996986605453786,0.7959618188363985,1794]
["High","O00178","GTP-binding protein 1 [OS=Homo sapiens]",29,15,40,15,669,72.4,8.34,104.63,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;other cytoplasmic organelle","nucleic acid binding activity;other molecular function","GTPBP1","ENSG00000100226","","","",1355,1347,1364.5,1233.9,1408.1,1317.5,1.0270236140926885,0.03846935355752587,0.5194108813930745,0.28448895636349986,0.7211166717491332,0.14199446371663205,5624]
["High","O00180","potassium channel subfamily K member 1 [OS=Homo sapiens]",12,2,2,2,336,38.1,6.37,7.92,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","KCNK1","ENSG00000135750","","Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK); Phase 4 - resting membrane potential","",26.1,39.6,34.3,43.4,43.1,32.7,0.8389261744966443,-0.2533842358000745,0.29154620525703656,0.5352926069496923,0.524635347003213,0.28014245242026886,4339]
["High","O00186","syntaxin-binding protein 3 [OS=Homo sapiens]",23,13,30,13,592,67.7,7.8,52.2,"cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STXBP3","ENSG00000116266","Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation","",1087.4,1232.7,1056.6,1077.7,1072.8,1093.8,1.0408100360632495,0.05770677849508769,0.46476849460605796,0.3327633192633421,0.6788089049540031,0.16825246902522512,5346]
["High","O00189","AP-4 complex subunit mu-1 [OS=Homo sapiens]",8,3,4,3,453,49.9,7.2,3.41,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","AP4M1","ENSG00000221838","","Lysosome Vesicle Biogenesis","Lysosome",256.6,256.6,297.6,264.4,294.3,262.5,0.9873356064296153,-0.01838753864170298,0.8493463986565591,0.0709151503411159,0.9263439978642847,0.03322770810031449,7159]
["High","O00192","armadillo repeat protein deleted in velo-cardio-facial syndrome [OS=Homo sapiens]",19,13,19,13,962,104.6,6.81,45.39,"cell adhesion;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","ARVCF","ENSG00000099889","22q11.2 copy number variation syndrome","","",759.7,778.7,762,684.6,618.1,656.2,1.1743325335647559,0.2318409915776131,0.004856724063502665,2.3136565704208065,0.05511817076719303,1.2587052039976825,688]
["High","O00193","Small acidic protein [OS=Homo sapiens]",31,7,43,7,183,20.3,4.72,97.37,"","","","SMAP","ENSG00000110696","","","",1583.1,1556.9,1511.5,1795.8,1630.7,1591.8,0.9269075184823546,-0.10950269269538246,0.13731017061351497,0.8622972932240084,0.33906319169839494,0.4697193541615633,3162]
["High","O00203-1","AP-3 complex subunit beta-1 [OS=Homo sapiens]",23,23,56,18,1094,121.2,6.04,99.11,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","AP3B1","ENSG00000132842","","Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions","Lysosome",2582.6,2676.4,2650.2,2462.5,2727,2615,1.0134153373054007,0.01922556828037779,0.6908461211631081,0.16061867646356703,0.8366878414831004,0.07743654201603736,6447]
["High","O00213","amyloid-beta A4 precursor protein-binding family B member 1 [OS=Homo sapiens]",9,5,6,5,710,77.2,5.06,9.96,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","APBB1","ENSG00000166313","Alzheimer's disease and miRNA effects; Alzheimer's disease","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks","Alzheimer disease",208.4,227.8,232.9,331.8,276.1,281.6,0.752220348510399,-0.41077276125845086,0.01876751195158831,1.7265932988926571,0.11289424754853739,0.9473281866983722,1298]
["High","O00214-1","Galectin-8 [OS=Homo sapiens]",7,2,2,2,317,35.8,8.25,3.31,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","LGALS8","ENSG00000116977","","","",38.3,29,33,29.3,48.8,38.4,0.8609442060085836,-0.2160083489294621,0.4359219100282664,0.3605913022022246,0.6563205309488438,0.18288400997692192,5186]
["High","O00217","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [OS=Homo sapiens]",16,3,5,3,210,23.7,6.34,9.73,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS8","ENSG00000110717","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",110.6,136.3,99.5,141.8,118.3,103,0.9540071605618285,-0.06792800007348251,0.740621693212997,0.13040357137822983,0.8685452358977291,0.061207557540243,6658]
["High","O00220","Tumor necrosis factor receptor superfamily member 10A [OS=Homo sapiens]",7,3,5,3,468,50.1,7.03,2.26,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TNFRSF10A","ENSG00000104689","Apoptosis modulation and signaling","Cell surface interactions at the vascular wall; Regulation by c-FLIP; RIPK1-mediated regulated necrosis; CASP8 activity is inhibited; TP53 Regulates Transcription of Death Receptors and Ligands; Dimerization of procaspase-8; TRAIL  signaling","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; p53 signaling pathway; Apoptosis; Necroptosis; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Salmonella infection; Influenza A; Lipid and atherosclerosis",144.2,143.8,143,167.5,164.6,155.6,0.8837400041008815,-0.1783061030594075,0.006296235625013892,2.200919027674319,0.06327028025753986,1.198800241816598,777]
["High","O00221","NF-kappa-B inhibitor epsilon [OS=Homo sapiens]",9,3,8,3,500,52.8,6.68,10.8,"other biological processes","cytosol;nucleus;other cell component","","NFKBIE","ENSG00000146232","TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19","Activation of NF-kappaB in B cells","Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Epstein-Barr virus infection; PD-L1 expression and PD-1 checkpoint pathway in cancer",167.9,113.8,137.6,164.8,125.5,143.7,0.9661290322580645,-0.049712212485451976,0.8124735282061208,0.09019078018452749,0.9080723315535917,0.04187955682752004,6986]
["High","O00231","26S proteasome non-ATPase regulatory subunit 11 [OS=Homo sapiens]",60,23,74,23,422,47.4,6.48,164.89,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD11","ENSG00000108671","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling pathway","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",3441.1,3502.2,3576.4,3495.4,3543,3551.2,0.9933991841051597,-0.009554533020529535,0.6151933129508782,0.2109883938898464,0.787576551487204,0.10370722258891202,6099]
["High","O00232-1","26s proteasome non-atpase regulatory subunit 12 [OS=Homo sapiens]",51,20,144,20,456,52.9,7.65,244.33,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","","PSMD12","ENSCANG00000030312; ENSCATG00000032968; ENSCSAG00000004164; ENSG00000197170; ENSMFAG00000032701; ENSMLEG00000034943; ENSMMUG00000002132; ENSMNEG00000032475; ENSNLEG00000001265; ENSPANG00000020562; ENSPPYG00000008565; ENSRROG00000042400","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease","Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",4184.1,4095.4,4526.8,3854.9,4510.4,4193.6,1.0196991774757342,0.02814360398663759,0.7385716597836854,0.13160736096299497,0.8671830856527843,0.06188920160746416,6650]
["High","O00233-1","26S proteasome non-ATPase regulatory subunit 9 [OS=Homo sapiens]",33,7,19,7,223,24.7,6.95,43.16,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMD9","ENSG00000110801","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",647,660.3,612.9,734.2,585.2,563.8,1.0196474086661,0.02807035836428428,0.8347880878046181,0.07842375682463944,0.9202351248875418,0.03610119396439346,7083]
["Medium","O00244","Copper transport protein ATOX1 [OS=Homo sapiens]",12,1,3,1,68,7.4,7.24,6.45,"stress response;transport;other biological processes","cytosol","other molecular function","ATOX1","ENSG00000177556","Copper homeostasis","Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface","Mineral absorption",154.2,155.2,173.5,163.2,177.2,150.1,0.9845056065239551,-0.02252867293394565,0.8130235576571871,0.08989687038096432,0.9084270088991582,0.04170996203322224,6988]
["High","O00255-2","Isoform 2 of Menin [OS=Homo sapiens]",26,12,20,12,610,67.5,6.55,48.24,"","","","MEN1","","","","",750.3,777.7,768.7,651.7,655.2,683.1,1.1541206030150752,0.20679399025765022,1.3302521854132172E-3,2.876066018919217,0.03147457292032242,1.5020401541384694,330]
["High","O00258-1","Tail-anchored protein insertion receptor WRB [OS=Homo sapiens]",13,2,2,2,174,19.8,9.67,2.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus","","GET1; WRB","ENSANAG00000014374; ENSCANG00000035340; ENSCATG00000041953; ENSCCAG00000026562; ENSCSAG00000008355; ENSG00000182093; ENSMLEG00000038301; ENSMNEG00000036276; ENSNLEG00000033928; ENSPANG00000032093; ENSPPAG00000034665; ENSPPYG00000011427; ENSPTRG00000013915; ENSSBOG00000020756","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",22.1,16.6,18.1,21.8,22.1,26.9,0.8022598870056495,-0.3178584305783157,0.11562926238697373,0.9369322447651417,0.3079240384438918,0.5115564060755967,2932]
["High","O00264","Membrane-associated progesterone receptor component 1 [OS=Homo sapiens]",69,19,142,17,195,21.7,4.7,283.11,"other metabolic processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PGRMC1","ENSG00000101856","","Neutrophil degranulation","",5966,5486.8,5105.5,5674.1,5034.1,5108.3,1.046900388834445,0.06612417830388517,0.48364949170256133,0.31546926431757455,0.6941792704436762,0.15852835935711906,5440]
["High","O00267","Transcription elongation factor Spt5 [OS=Homo sapiens]",34,28,82,28,1087,120.9,5.06,189.56,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SUPT5H","ENSG00000196235","Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","",2997.8,2939.3,3152,3172.1,3275.1,3277.1,0.9346791028660163,-0.09745695573378009,0.04286827826436539,1.3678639588803423,0.17442184298497393,0.7583991289571785,1919]
["High","O00268","Transcription initiation factor TFIID subunit 4 [OS=Homo sapiens]",10,7,11,7,1085,110,9.94,32.34,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","TAF4","ENSG00000130699","","RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors; Huntington disease",362.3,339.4,346.7,348.2,320.8,347.9,1.0309764971973647,0.04401144447780297,0.4061143574724463,0.39135165650642745,0.631661534491008,0.19951556899281142,5020]
["High","O00273-1","DNA fragmentation factor subunit alpha [OS=Homo sapiens]",56,13,36,4,331,36.5,4.79,78.92,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DFFA","ENSG00000160049","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis","Apoptosis induced DNA fragmentation","Apoptosis",806.5,854.8,679.6,744.4,711.5,761.7,1.0556006493506491,0.07806414324808951,0.49109097349223096,0.308838048353719,0.699842730612765,0.1549995441297933,5479]
["High","O00291","Huntingtin-interacting protein 1 [OS=Homo sapiens]",38,32,79,31,1037,116.1,5.3,156.45,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HIP1","ENSG00000127946","","Clathrin-mediated endocytosis; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","Huntington disease; Pathways of neurodegeneration",3560.2,3556.7,3685,3797.6,3702.9,3812.3,0.9548387667067393,-0.06667095347794479,0.03510025693092032,1.4546897045235625,0.1564285423040102,0.805684001696989,1752]
["High","O00299","chloride intracellular channel protein 1 [OS=Homo sapiens]",87,18,146,17,241,26.9,5.17,373.46,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion;nucleus;other cell component","transporter activity","CLIC1","ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685","VEGFA-VEGFR2 signaling pathway","","",5406.9,5772.8,5715.3,5656.5,5913.6,5562.1,0.9861547261881136,-0.02011407385038388,0.6362339591636809,0.19638315402181333,0.8009859324653371,0.09637511126448547,6202]
["Medium","O00300","Tumor necrosis factor receptor superfamily member 11B [OS=Homo sapiens]",2,1,1,1,401,46,8.29,2.13,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","TNFRSF11B","ENSG00000164761","Osteoclast signaling; RANKL/RANK signaling pathway; Ectoderm differentiation; Vitamin D receptor pathway; Osteoblast signaling; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Overlap between signal transduction pathways contributing to LMNA laminopathies; Monoamine transport","TNFs bind their physiological receptors","Cytokine-cytokine receptor interaction; Osteoclast differentiation",76.5,69.4,91.1,103.7,118.2,107.3,0.7199270959902795,-0.47407727663600424,0.016481597576093535,1.7830006940433611,0.10565543011012998,0.9761081776815822,1218]
["High","O00303","Eukaryotic translation initiation factor 3 subunit F [OS=Homo sapiens]",42,11,55,11,357,37.5,5.45,110.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3F","ENSG00000175390","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",2050.6,2103.5,2173.4,2060.7,2239.1,2138.9,0.9827294329600696,-0.025133829346113922,0.5861497984438794,0.23199138001634956,0.7687985261632472,0.1141874579094675,5953]
["High","O00308","NEDD4-like E3 ubiquitin-protein ligase WWP2 [OS=Homo sapiens]",14,10,14,9,870,98.9,7.12,23.19,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","WWP2","ENSG00000198373","","RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle","Ubiquitin mediated proteolysis",407.9,402.5,435.2,474.3,481.6,440.9,0.8917525773195875,-0.16528461455040333,0.035208063538258734,1.4533578606945359,0.15673007987840604,0.8048476450659222,1754]
["High","O00311-1","Cell division cycle 7-related protein kinase [OS=Homo sapiens]",5,2,5,2,574,63.8,8.73,10.07,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CDC7","ENSG00000097046","Cell cycle; Retinoblastoma gene in cancer; DNA replication","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Transcriptional Regulation by E2F6","Cell cycle",36,37.8,43.2,46.7,52.5,46.3,0.8041237113402062,-0.3145106233248793,0.032218131914088795,1.4918996446406698,0.14867563474302914,0.8277601986850393,1692]
["High","O00330-1","Pyruvate dehydrogenase protein X component, mitochondrial [OS=Homo sapiens]",24,11,21,11,501,54.1,8.66,44.04,"other metabolic processes","mitochondrion;other cell component","other molecular function","PDHX","ENSG00000110435","Amino acid metabolism","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Metabolic pathways",900.8,894.6,883.1,868.8,867.3,901.7,1.0154295246038365,0.022090113555480864,0.334170462223567,0.47603194061929427,0.5663561903715241,0.2469103482133385,4607]
["Low","O00339-1","Matrilin-2 [OS=Homo sapiens]",1,1,2,1,956,106.8,6.27,3.59,"","non-structural extracellular;extracellular matrix","extracellular structural activity;other molecular function","MATN2","ENSG00000132561","","","",163.3,136.4,164.6,164.7,171.6,148.3,0.9581097812628974,-0.06173712388468462,0.5878416671910557,0.23073963366013048,0.769982844728697,0.11351895083097263,5961]
["High","O00391","Sulfhydryl oxidase 1 [OS=Homo sapiens]",3,2,2,2,747,82.5,8.92,3.63,"cell organization and biogenesis;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","QSOX1","ENSG00000116260","","Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",165.3,186.5,184.7,134.4,154.5,138.7,1.2546772684752105,0.3273163179233938,0.016471073013029452,1.7832781076633728,0.10567472316001147,0.9760288812348022,1217]
["High","O00399","Dynactin subunit 6 [OS=Homo sapiens]",22,4,8,4,190,20.7,6.32,12.06,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","DCTN6","ENSG00000104671","","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","Vasopressin-regulated water reabsorption; Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection",418.9,397.5,364.7,470.6,444.7,457.9,0.8601077774541218,-0.2174106440770593,0.021379381516549334,1.670004862636827,0.11957751495789197,0.9223504762653338,1396]
["High","O00400","Acetyl-coenzyme A transporter 1 [OS=Homo sapiens]",12,6,10,6,549,60.9,7.33,16.81,"transport;signal transduction","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC33A1","ENSG00000169359","Ganglio sphingolipid metabolism","Transport of vitamins, nucleosides, and related molecules; Defective SLC33A1 causes spastic paraplegia 42 (SPG42)","Glycosphingolipid biosynthesis; Metabolic pathways",384.6,356.6,385.1,382.2,399.6,376.2,0.9726252158894647,-0.04004410009554839,0.4191435909253345,0.3776371701996265,0.6430876710444118,0.1917298164142858,5089]
["High","O00401","Neural Wiskott-Aldrich syndrome protein [OS=Homo sapiens]",30,10,24,10,505,54.8,7.93,39.06,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity","WASL","ENSG00000106299","Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 signaling pathway","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle; RHOV GTPase cycle; NOSTRIN mediated eNOS trafficking; Nephrin family interactions; EPHB-mediated forward signaling; DCC mediated attractive signaling","Endocytosis; Adherens junction; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",757.1,717.6,743.4,892.9,804.1,819,0.8815977742448331,-0.18180751332175257,0.02903862822010663,1.5370239034853588,0.13961429134396094,0.85507012373188,1624]
["High","O00410","Importin-5 [OS=Homo sapiens]",64,47,286,44,1097,123.6,4.94,616.8,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","IPO5","ENSG00000065150","","vRNP Assembly","Nucleocytoplasmic transport",8417.5,8395.8,8526.8,8759.2,8957.6,8917.8,0.9513978058615483,-0.07187939676411641,4.0819790071657865E-3,2.3891292331073326,0.0509138851245215,1.2931637616591267,626]
["High","O00411","DNA-directed RNA polymerase, mitochondrial [OS=Homo sapiens]",17,16,27,16,1230,138.5,8.98,50.34,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","POLRMT","ENSG00000099821","Mitochondrial gene expression","Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis","",588.5,612,602,582.7,660.3,615.7,0.9697638134179802,-0.04429467408408211,0.4698705204689874,0.328021801623699,0.6830662863194663,0.16553714934056338,5371]
["High","O00418","Eukaryotic elongation factor 2 kinase [OS=Homo sapiens]",10,7,10,7,725,82.1,5.33,18.04,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;kinase activity;other molecular function","EEF2K","ENSG00000103319","Translation factors; AMP-activated protein kinase (AMPK) signaling; BDNF-TrkB signaling","mTORC1-mediated signalling","AMPK signaling pathway; Oxytocin signaling pathway",336.2,380.4,353.6,368.9,357.8,368.5,0.9771731190650108,-0.03331391765653734,0.566579445604595,0.24673918488515842,0.7556973541647893,0.12165209832429622,5854]
["High","O00422","Histone deacetylase complex subunit SAP18 [OS=Homo sapiens]",60,10,53,10,153,17.6,9.35,91.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SAP18","ENSG00000150459","Hedgehog signaling pathway","Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression","Nucleocytoplasmic transport; mRNA surveillance pathway",4137.1,4669.3,3753.9,3877.3,3810.1,3792.1,1.0941504420924257,0.12981111759912983,0.2480786626125419,0.605410588037897,0.4775636582048144,0.32096872970454127,4056]
["High","O00423-1","Echinoderm microtubule-associated protein-like 1 [OS=Homo sapiens]",5,4,7,4,815,89.8,7.06,15.94,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","EML1","ENSG00000066629","","","",179.2,187.3,179.9,184.5,206.8,199.1,0.9254742547425475,-0.11173523777030546,0.10541336787849374,0.9771043110614803,0.29145452421929147,0.5354291987826111,2824]
["High","O00425","Insulin-like growth factor 2 mRNA-binding protein 3 [OS=Homo sapiens]",56,30,200,24,579,63.7,8.87,408.36,"protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP3","ENSG00000136231","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",8198.9,7698.9,8184.3,8854.6,9176.2,9095.9,0.8877637161910586,-0.17175234943784623,0.005987293711166673,2.2227694366914283,0.062001046812718015,1.2076009779025672,754]
["High","O00429","Dynamin-1-like protein [OS=Homo sapiens]",73,46,289,1,736,81.8,6.81,653.37,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","DNM1L","ENSG00000087470","Synaptic vesicle pathway; CAMKK2 pathway","Apoptotic execution phase","Necroptosis; NOD-like receptor signaling pathway; TNF signaling pathway",92.8,104.9,86.8,88.2,97.8,104.9,0.977999312478515,-0.03209464390636203,0.7815654838117609,0.10703462856396186,0.8889240054773823,0.05113536547810038,6865]
["High","O00429-6","Isoform 6 of Dynamin-1-like protein [OS=Homo sapiens]",71,46,287,0,749,83.3,7.08,646.88,"","","","DNM1L","","","","",10473.9,10174.2,10598.7,10282.3,10316.3,10517.7,1.0041939433673026,6.0379287637967105E-3,0.7803141691112465,0.10773050700096028,0.8880182236438731,0.05157812166873577,6861]
["High","O00429-8","Isoform 8 of Dynamin-1-like protein [OS=Homo sapiens]",72,46,285,1,738,82,6.96,642.25,"","","","DNM1L","","","","",189.1,216.2,188.5,172.6,214.5,194.9,1.020274914089347,0.028957940191009175,0.8081415518997416,0.09251256270965862,0.9055638974215244,0.04308090005063,6968]
["High","O00442","RNA 3'-terminal phosphate cyclase [OS=Homo sapiens]",44,14,50,14,366,39.3,7.85,106.23,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RTCA","ENSG00000137996","","","",1646,1549,1697.9,1698.9,1737.8,1758,0.9419023235220513,-0.08635063661698061,0.09881847966231773,1.0051618320833682,0.28139120685754077,0.5506894778782266,2742]
["High","O00443","phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [OS=Homo sapiens]",15,23,41,23,1686,190.6,8.02,76.67,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2A","ENSG00000011405","Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection",1874.4,1772.7,1896.6,2047.1,1971.5,1967.8,0.9260490445008689,-0.11083949277928955,0.03280447040454946,1.484066969101267,0.15058042617208828,0.8222314780552005,1701]
["High","O00458","Interferon-related developmental regulator 1 [OS=Homo sapiens]",11,3,3,3,451,50.2,7.18,9.27,"other biological processes","nucleus","","IFRD1","ENSG00000006652","Hypertrophy model","","",31.2,16.3,22.8,39.4,32.3,33.3,0.6695238095238096,-0.5787927334809495,0.07559523576887363,1.1215055741348652,0.23935425826576046,0.6209588417359425,2466]
["High","O00459","Phosphatidylinositol 3-kinase regulatory subunit beta [OS=Homo sapiens]",16,7,14,7,728,81.5,6.43,30.92,"other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R2","ENSG00000105647","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway","Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOU GTPase cycle; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",395,336.2,356.9,396.6,400.4,406.5,0.9041130037390942,-0.1454249906704235,0.09232722481027876,1.034670218351387,0.2703003267036582,0.5681534293826278,2667]
["High","O00461","Golgi integral membrane protein 4 [OS=Homo sapiens]",32,17,34,17,696,81.8,4.77,79.63,"","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","GOLIM4","ENSG00000173905","","Intra-Golgi traffic","",1278.8,1257.6,1279.7,1261.9,1231.9,1193.5,1.034930708106202,0.04953417794871868,0.11125258807394396,0.9536898772175131,0.3014088159893666,0.5208440490368481,2882]
["High","O00462","Beta-mannosidase [OS=Homo sapiens]",8,7,11,6,879,100.8,5.52,16.56,"protein metabolism;other metabolic processes","plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","MANBA","ENSG00000109323","","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","Other glycan degradation; Lysosome",303.6,290.7,309.1,260.6,279.6,292.4,1.0850348306509727,0.11774135529729758,0.09265053941668346,1.0331520478506733,0.27094210178481815,0.5671235045566131,2670]
["High","O00463","TNF receptor-associated factor 5 [OS=Homo sapiens]",4,2,4,2,557,64.4,7.43,1.67,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","signal transduction activity or receptor binding;other molecular function","TRAF5","ENSG00000082512","RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Small cell lung cancer; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling","","NF-kappa B signaling pathway; Necroptosis; NOD-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Shigellosis; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Small cell lung cancer",25.9,28.4,26.1,30.9,29.2,26.8,0.9252013808975835,-0.11216067563547141,0.2054592388586678,0.6872743250999684,0.42745156861403627,0.36911308485441546,3753]
["High","O00468","Agrin [OS=Homo sapiens]",18,26,37,26,2067,217.1,6.39,78.62,"","","","","","","","",1385.5,1331.7,1263.4,1385.7,1285.8,1387.8,0.9806124208607394,-0.02824505934911621,0.619349101025161,0.20806448844032022,0.7897889565253076,0.1024889432174177,6123]
["High","O00469-1","procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [OS=Homo sapiens]",13,7,15,7,737,84.6,6.71,30.91,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","PLOD2","ENSG00000152952","Clear cell renal cell carcinoma pathways; Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","Lysine degradation; Metabolic pathways",727.5,678.1,759.8,638.9,696.8,662.7,1.083566853482786,0.11578816701043122,0.12828787802316266,0.8918143783590168,0.3259589168906131,0.48683713395675954,3073]
["High","O00471","Exocyst complex component 5 [OS=Homo sapiens]",20,15,29,15,708,81.8,6.71,45.03,"cell organization and biogenesis;transport;other biological processes","cytosol;other cell component","other molecular function","EXOC5","ENSG00000070367","Ciliary landscape","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium","Salmonella infection",1311.8,1302.2,1285.5,1355.9,1351.7,1366,0.9572613904163392,-0.06301517313718248,0.002713176005316584,2.566522032387158,0.042710641632080416,1.3694639042187198,496]
["High","O00483","Cytochrome c oxidase subunit NDUFA4 [OS=Homo sapiens]",56,5,13,5,81,9.4,9.38,22.67,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NDUFA4","ENSG00000189043","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; Oxidative phosphorylation","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",616.2,613.5,599.7,518.8,593.4,600.4,1.0682003970571063,0.09518232560201098,0.2172258839340162,0.663088426873471,0.4422685011099866,0.3543139904998354,3835]
["High","O00487","26S proteasome non-ATPase regulatory subunit 14 [OS=Homo sapiens]",41,12,33,12,310,34.6,6.52,69.71,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMD14","ENSG00000115233","Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Metalloprotease DUBs","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",1809.1,1686.6,1891.8,1671.6,1828.8,1808.4,1.014824442435202,0.021230172795322036,0.7516639356983971,0.12397628639473542,0.874402862028171,0.05828842955674393,6712]
["High","O00499","Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",35,15,33,1,593,64.7,5.06,96.43,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","BIN1","ENSG00000136717","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway","Clathrin-mediated endocytosis","Endocytosis; Fc gamma R-mediated phagocytosis",1528.6,1521,1503.4,1855.3,1753.5,1732.3,{"$f":"AVERAGE(T130:V130)/AVERAGE(W130:Y130)","v":0.8524461253299882},{"$f":"LOG(Z130,2)","v":-0.23031943632276144},{"$f":"TTEST(T130:V130,W130:Y130,2,2)","v":2.4567925480414613E-3},{"$f":"-LOG10(AB130)","v":2.6096315138677313},{"$f":"AB130*7808/AF130","v":0.040555256268726705},{"$f":"-LOG10(AD130)","v":1.3919528499469074},473]
["High","O00499-2","Isoform IIB of Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",39,15,35,1,518,56.5,5.12,96.18,"","","","BIN1","","","","",269.9,246.8,238.5,283.5,265.6,281.5,0.9092222489766434,-0.13729510706295378,0.08373356568610055,1.0771004145265026,0.2544926745336991,0.5943247141342134,2569]
["High","O00505","Importin subunit alpha-4 [OS=Homo sapiens]",34,14,51,10,521,57.8,4.94,112.11,"cell organization and biogenesis;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","KPNA3","ENSG00000102753","","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis",1049.7,1120.4,1011.5,1120.9,1134.3,1132.4,0.9391899870114536,-0.09051106736563762,0.0997285128464131,1.001180657119466,0.2825399957564563,0.5489200656964187,2756]
["High","O00506","serine/threonine-protein kinase 25 [OS=Homo sapiens]",19,6,24,2,426,48.1,6.74,36.62,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","kinase activity;other molecular function","STK25","ENSG00000115694","","","",57.3,68.7,58.4,58.1,53.1,60.4,1.0745920745920747,0.10378910292979257,0.3693728023951831,0.432535085627081,0.6005961768224884,0.22141743668945413,4802]
["High","O00507-1","Probable ubiquitin carboxyl-terminal hydrolase FAF-Y [OS=Homo sapiens]",14,31,68,5,2555,290.9,5.86,132.56,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","USP9Y","ENSG00000114374","","","",59.7,71,72.7,78.7,83.5,81.3,0.835318275154004,-0.25960209311220456,0.036150608848538664,1.4418843839203779,0.15866439229308033,0.7995205273456676,1779]
["High","O00515","Ladinin-1 [OS=Homo sapiens]",14,6,8,6,517,57.1,9.67,18.53,"","extracellular matrix;cytoskeleton","other molecular function","LAD1","ENSG00000159166","","","",406.4,418.3,387.1,511.1,401.9,409.8,0.9160870879951619,-0.1264433399641726,0.36586312023627,0.43668136609445823,0.5976274566537231,0.22356945804794165,4780]
["High","O00522","Krev interaction trapped protein 1 [OS=Homo sapiens]",1,1,1,1,736,84.3,8.41,3.49,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","KRIT1","ENSG00000001631","","","Rap1 signaling pathway",85.5,78.9,85.9,94.1,96.4,104.6,0.8481870552355134,-0.23754562974367524,0.01882524644593972,1.7252593296339749,0.11306732634607486,0.9466628772821764,1300]
["High","O00534","von Willebrand factor A domain-containing protein 5A [OS=Homo sapiens]",10,6,8,6,786,86.4,6.58,19.04,"","nucleus","","VWA5A","ENSG00000110002","","","",313.6,339.9,326.9,247.7,275.1,271.1,1.2349162363018014,0.30441318790683847,0.005548296518765264,2.2558403368881614,0.05934397153221806,1.226623392349982,730]
["High","O00541-1","Pescadillo homolog [OS=Homo sapiens]",35,19,77,19,588,68,7.33,173.63,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PES1","ENSG00000100029","","Major pathway of rRNA processing in the nucleolus and cytosol","",4350,4395,4580.4,4460.2,4686.2,4639.3,0.9666103280936043,-0.0489936850484566,0.19449983425666195,0.711080764422838,0.41234176103068604,0.3847426786191155,3683]
["Medium","O00559","Receptor-binding cancer antigen expressed on SiSo cells [OS=Homo sapiens]",8,1,1,1,213,24.4,6.29,2.55,"other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","EBAG9","ENSG00000147654","","Estrogen-dependent gene expression","Estrogen signaling pathway",21.6,23.3,19.3,23.7,20.2,21.4,0.983154670750383,-0.02450969442412744,0.8244504783442319,0.08383542568076481,0.914650374383598,0.03874488352130231,7038]
["High","O00560-1","Syntenin-1 [OS=Homo sapiens]",40,7,14,7,298,32.4,7.53,38.76,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SDCBP","ENSG00000137575; ENSPPAG00000038846; ENSPTRG00000020277","Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling pathway","Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death","",503.3,526.5,590.6,389.1,386.7,419,1.356210244392367,0.4395808473756462,7.2365893104344705E-3,2.1404660736739496,0.06750691676926206,1.1706517270085741,837]
["High","O00562","Membrane-associated phosphatidylinositol transfer protein 1 [OS=Homo sapiens]",8,7,7,6,1244,134.8,5.95,14.49,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","PITPNM1","ENSG00000110697","","Synthesis of PI","",438,431.5,402.4,390.7,389.6,367.5,1.1081198815124589,0.14811396722445172,0.035866730038689426,1.4453082160446227,0.15795117210495602,0.8014771469869051,1773]
["High","O00566","U3 small nucleolar ribonucleoprotein protein Mpp10 [OS=Homo sapiens]",24,16,43,16,681,78.8,4.86,96.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","MPHOSPH10","ENSG00000124383","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1253.2,1182.2,1260.4,1363.4,1325.9,1368.7,0.9107442089699359,-0.13488217836637276,0.013078543897232307,1.8834406055988104,0.0935139842029211,1.0291234393088935,1092]
["High","O00567","Nucleolar protein 56 [OS=Homo sapiens]",61,28,124,28,594,66,9.19,275.69,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP56","ENSG00000101361","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","Ribosome biogenesis in eukaryotes; Spinocerebellar ataxia",5437.5,5562.4,5358.3,4958,5241.8,5392.4,1.0491271276663974,0.06918950664855641,0.1433786588841018,0.8435154861759426,0.34842843715128136,0.45788640706882533,3213]
["High","O00571","ATP-dependent RNA helicase DDX3X [OS=Homo sapiens]",66,41,252,13,662,73.2,7.18,546.44,"cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","DDX3X","ENSG00000215301","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Hepatitis B infection","Neutrophil degranulation","RIG-I-like receptor signaling pathway; Hepatitis B; Viral carcinogenesis",13622.8,13579.1,13765.6,14661.8,14809,15023.9,0.9207276372242088,-0.1191536427379468,5.9401712987058126E-4,3.226201030943046,0.021572491860602318,1.666099686200016,215]
["High","O00592","Podocalyxin [OS=Homo sapiens]",22,10,69,10,558,58.6,5.49,125.4,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","","PODXL","ENSG00000128567","Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Malignant pleural mesothelioma","","Salmonella infection",3158.1,3025.3,3221.6,3975.4,3680.7,3931,0.8116785045438462,-0.3010196873595415,0.002571311291932215,2.5898453429663726,0.04173970596134457,1.3794506146815688,481]
["High","O00622","Protein CYR61 [OS=Homo sapiens]",23,8,17,8,381,42,8.21,29.16,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi","signal transduction activity or receptor binding;other molecular function","CCN1","ENSG00000142871","Oncostatin M signaling pathway; VEGFA-VEGFR2 signaling pathway; Hypertrophy model","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",733.2,732.5,761.8,403,410.3,441.8,1.7747589833479407,0.827623116370668,2.9547425121217e-05,4.5294803592622594,0.006408508204068398,2.193243055370911,36]
["High","O00625","Pirin [OS=Homo sapiens]",27,8,29,8,290,32.1,6.92,33.91,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PIR","ENSG00000087842","","Digestion","",1784.5,1749.4,1741.7,1883.2,1843.9,1873.2,0.9420209631626878,-0.08616892983238364,0.003605981377062011,2.44297652050327,0.04821147704126743,1.3168495629570343,584]
["High","O00629","Importin subunit alpha-3 [OS=Homo sapiens]",43,16,92,12,521,57.9,4.96,245.96,"transport","other membranes;cytosol;nucleus","other molecular function","KPNA4","ENSG00000186432","Leptin signaling pathway","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis",3634.4,3687,3707.9,3567.3,3593.8,3562.5,1.0285072177253907,0.040551918257684116,0.013078646455747089,1.8834371999886175,0.09342915967655377,1.0295175572796849,1093]
["Low","O00635","E3 ubiquitin-protein ligase TRIM38 [OS=Homo sapiens]",2,1,2,1,465,53.4,7.02,0,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM38","ENSG00000112343","","Interferon gamma signaling","",75.8,71.4,76.4,84.8,86,81.6,0.8858954041204437,-0.17479172213935906,0.009452133842747233,2.02447013736182,0.07818036127560422,1.106902327001254,944]
["High","O00743","Serine/threonine-protein phosphatase 6 catalytic subunit [OS=Homo sapiens]",31,8,22,8,305,35.1,5.69,47.21,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","cytosol;mitochondrion;nucleus","other molecular function","PPP6C","ENSG00000119414","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",931.2,953.2,959.3,910,1014.3,973.4,0.9813645304896987,-0.027138965942352888,0.5984938268914708,0.22294032472423145,0.778450741357422,0.10876886342146988,6003]
["High","O00746","Nucleoside diphosphate kinase, mitochondrial [OS=Homo sapiens]",34,6,16,6,187,20.6,10.29,30.44,"other metabolic processes;transport","other membranes;mitochondrion","kinase activity;other molecular function","NME4","ENSG00000103202","Pyrimidine metabolism","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",1224.9,1050.6,1125.9,909.8,1007.6,992.8,1.168785650470758,0.22501037096643936,0.049915250374422966,1.3017667461284106,0.1882793598664225,0.7251972869266929,2070]
["High","O00750","Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [OS=Homo sapiens]",2,3,4,3,1634,184.7,7.3,10.18,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2B","ENSG00000133056","Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)","Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection",105.1,117.3,120.6,102.4,120.3,115.9,1.0129946839929118,0.01862660316453271,0.8476337221443874,0.07179177370511115,0.9258987272668406,0.033436512880082356,7148]
["High","O00754","Lysosomal alpha-mannosidase [OS=Homo sapiens]",9,8,12,8,1011,113.7,7.28,23.14,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MAN2B1","ENSG00000104774","","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","Other glycan degradation; Lysosome",657.1,663.2,662.5,626.3,597.1,558.6,1.1126823793490461,0.15404182706104252,0.027333377665924495,1.5633066979438446,0.13516086942086034,0.8691490232935035,1579]
["High","O00762","Ubiquitin-conjugating enzyme E2 C [OS=Homo sapiens]",23,4,9,4,179,19.6,7.37,12.57,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","UBE2C","ENSG00000175063","Gastric cancer network 1; Gastric cancer network 2","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Ubiquitin mediated proteolysis",469.9,486.1,489.5,512.3,437.1,381.8,1.0858623798076923,0.11884127022331964,0.3761285674624278,0.4246636800843009,0.6064034389317853,0.21723834447220486,4843]
["High","O00763","Acetyl-CoA carboxylase 2 [OS=Homo sapiens]",3,6,16,1,2458,276.4,6.49,36.48,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","ACACB","ENSG00000076555","AMP-activated protein kinase (AMPK) signaling; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; IL-18 signaling pathway; 7q11.23 copy number variation syndrome","ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP)","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; AMPK signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Glucagon signaling pathway; Insulin resistance; Alcoholic liver disease",58.8,55.7,62.5,47.5,52.8,48.9,1.1863270777479895,0.2465018247151223,0.02140342751538941,1.6695166737617138,0.11945529809875662,0.922794583594906,1399]
["High","O00764-1","Pyridoxal kinase [OS=Homo sapiens]",40,11,42,11,312,35.1,6.13,76.73,"other metabolic processes","non-structural extracellular;nucleus;other cell component","kinase activity;other molecular function","HEL-S-1a; PDXK","ENSG00000160209","","Neutrophil degranulation; Vitamins B6 activation to pyridoxal phosphate","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors",1032.2,859.6,984.3,992.4,961.7,949.1,0.9906654725819788,-0.013530123775766597,0.8729988755068867,0.05898631570046529,0.9351591740921623,0.029114461270417828,7289]
["High","O00767","acyl-CoA desaturase [OS=Homo sapiens]",11,3,19,3,359,41.5,9,30.34,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","SCD","ENSG00000099194","Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Adipogenesis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; AMPK signaling pathway; Alcoholic liver disease",738.9,787.1,780.5,987.5,814.8,1002.5,0.8223402738163149,-0.28219260880651986,0.055492146107498995,1.2557684789230623,0.19948557864058572,0.7000884951812363,2172]
["High","O14494","Phospholipid phosphatase 1 [OS=Homo sapiens]",11,2,2,2,284,32.1,7.97,6.23,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","PLPP1","ENSG00000067113","Androgen receptor signaling pathway; Androgen receptor signaling pathway; Sphingolipid pathway; Triacylglyceride synthesis; Androgen receptor signaling pathway","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",106.3,125.5,106.6,115.4,125.2,117.1,0.9460441710930946,-0.080020549875276,0.41211851689289153,0.3849778717560732,0.6382033676913322,0.1950409084378649,5042]
["High","O14495","Phospholipid phosphatase 3 [OS=Homo sapiens]",10,3,5,3,311,35.1,9.14,8.06,"cell adhesion;cell-cell signaling;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","PLPP3","ENSG00000162407","Triacylglyceride synthesis; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",227.3,203.5,228,257.7,268.4,268.4,0.8292007551919447,-0.27020666450952646,6.809999979235256E-3,2.166852889411446,0.06548334955402571,1.1838691139939859,812]
["High","O14497","AT-rich interactive domain-containing protein 1A [OS=Homo sapiens]",28,46,118,45,2285,241.9,6.7,267.26,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ARID1A","ENSG00000117713","Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",4964.4,4776.3,5075.9,5431.1,5127.7,5232.3,0.9382880230002977,-0.09189724509887821,0.05979276880312153,1.2233513353894268,0.20795632018475407,0.6820278760701333,2245]
["High","O14524-1","Nuclear envelope integral membrane protein 1 [OS=Homo sapiens]",9,5,9,5,444,50.6,6.93,16.27,"cell organization and biogenesis","other membranes;nucleus","","NEMP1","ENSG00000166881","","","",382.1,489.8,363.3,427.9,421.3,427.6,0.9674185463659146,-0.047787898954265606,0.7430562458214632,0.12897831096976792,0.869702168696445,0.060629446963715784,6671]
["High","O14530","Thioredoxin domain-containing protein 9 [OS=Homo sapiens]",36,7,21,7,226,26.5,5.88,38,"","cytosol;cytoskeleton;nucleus;other cell component","","TXNDC9","ENSG00000115514","","","",737.5,828.7,662.5,715.7,637.5,653.4,1.1106847403568225,0.15144937652282522,0.2397371637942102,0.6202646368896568,0.4698463290424682,0.32804416198268255,3984]
["High","O14531","dihydropyrimidinase-related protein 4 [OS=Homo sapiens]",21,10,33,10,572,61.8,7.09,65.86,"cell organization and biogenesis;developmental processes;other biological processes","cytosol","cytoskeletal activity;other molecular function","DPYSL4","ENSG00000151640","","CRMPs in Sema3A signaling","",871.5,817.7,918.3,915.3,907.5,949.5,0.9405547740143563,-0.08841613210872296,0.15912936233375694,0.798249677531467,0.36879847465181775,0.43321088385395184,3369]
["High","O14545","TRAF-type zinc finger domain-containing protein 1 [OS=Homo sapiens]",6,3,6,3,582,64.8,5.29,11.48,"other biological processes","","other molecular function","TRAFD1","ENSG00000135148","","","",328.9,331.3,302.1,331.1,285.1,294.4,1.0567757522512629,0.07966926939970088,0.3648909418910526,0.43783691749465464,0.5976648781802683,0.22354226476306122,4767]
["High","O14548","Cytochrome c oxidase subunit 7A-related protein, mitochondrial [OS=Homo sapiens]",11,1,1,1,114,12.6,9.42,3.4,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity","COX7A2L","ENSG00000115944","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",104.7,118.4,108.2,107.9,95.5,109.9,1.05745292052346,0.08059343370996076,0.3807788924697185,0.4193271336541464,0.609996223308076,0.21467285384421647,4874]
["High","O14561","Acyl carrier protein, mitochondrial [OS=Homo sapiens]",13,2,5,2,156,17.4,4.93,6.75,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","NDUFAB1","ENSG00000004779","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",256.2,276.7,260.6,298.8,264.3,225.9,1.005703422053232,0.008204922821723384,0.948813432618693,0.02281917550713035,0.9745245043260662,0.011207236115579907,7602]
["High","O14562","Ubiquitin domain-containing protein UBFD1 [OS=Homo sapiens]",33,7,35,7,309,33.4,5.77,62.32,"","","","UBFD1","ENSG00000103353","","","",1386.2,1397.8,1297.2,1501.6,1249,1250.2,1.020095980803839,0.02870490172142481,0.7802520821266071,0.10776506373294104,0.8880770054292345,0.051549374781057304,6860]
["High","O14578-4","Isoform 4 of Citron Rho-interacting kinase [OS=Homo sapiens]",19,36,55,36,2069,236.5,6.67,103.88,"","","","CIT","","","","",2488.1,2454,2442,2334.2,2420.4,2341.1,1.0406443338923572,0.05747707593310364,0.03587094292135654,1.4452572070943224,0.15788067775081843,0.8016710179313945,1774]
["High","O14579-1","coatomer subunit epsilon [OS=Homo sapiens]",34,12,29,12,308,34.5,5.12,61.56,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","COPE","ENSG00000105669; ENSPTRG00000010723","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",1114,1092.7,1043.7,1006.3,1058.7,1036.1,1.0481442068943276,0.06783722093911268,0.12549992664452034,0.9013565280306669,0.3220188719160088,0.49211867573019863,3043]
["High","O14617-5","Isoform 5 of AP-3 complex subunit delta-1 [OS=Homo sapiens]",39,34,102,4,1215,136.6,7.64,215.34,"","","","AP3D1","","","","",3489.3,3565.8,3712.7,3435.4,3664.9,3599.9,1.006317638922637,0.009085756204866796,0.823546073872762,0.08431209889985704,0.9146867346797334,0.03872761926104561,7030]
["High","O14618","copper chaperone for superoxide dismutase [OS=Homo sapiens]",37,9,26,9,274,29,5.58,58.72,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CCS","ENSG00000173992","Amyotrophic lateral sclerosis (ALS); Copper homeostasis","Detoxification of Reactive Oxygen Species","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",1458.7,1357.3,1369.4,1418.4,1392,1396.4,0.9949129980032327,-7.3577228362731615E-3,0.8394425869954588,0.07600900173405385,0.922370914615894,0.035094400228727535,7106]
["High","O14628-1","Zinc finger protein 195 [OS=Homo sapiens]",17,8,12,3,629,72.3,8.09,18.84,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF195","ENSG00000005801","","Generic Transcription Pathway","Herpes simplex virus 1 infection",226.4,210.5,202.6,200.6,216.7,219,1.005029074336005,0.007237237517288203,0.9121668134816066,0.03992573234063084,0.9548462903424566,0.020066534833925103,7459]
["High","O14639-1","Actin-binding LIM protein 1 [OS=Homo sapiens]",8,5,5,5,778,87.6,8.59,7.43,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ABLIM1","ENSG00000099204","Male infertility","DCC mediated attractive signaling","Axon guidance",149.9,167.1,164.4,213.4,149.2,144,0.950256612712199,-0.07361093523800412,0.7328618670693332,0.13497787532179553,0.863335162655002,0.06382057041045931,6628]
["High","O14641","Segment polarity protein dishevelled homolog DVL-2 [OS=Homo sapiens]",18,12,21,10,736,78.9,6.02,43.31,"cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","DVL2","ENSG00000004975","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)","RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; Degradation of DVL; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",1157.6,1197.2,1165.9,1051.7,1136.3,1099.4,1.070967938188234,0.09891529044371569,0.04643967239483936,1.3331108526202715,0.1819372614445086,0.7400783466621237,1993]
["High","O14646","Chromodomain-helicase-DNA-binding protein 1 [OS=Homo sapiens]",21,35,65,30,1710,196.6,7.14,121.56,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD1","ENSG00000153922","","Estrogen-dependent gene expression","",2725.2,2871.5,2514.9,2951.3,2811.6,3032.3,0.922275786792796,-0.11672987270975412,0.13499939409562053,0.8696681807014315,0.3357997034401418,0.4739196917428385,3139]
["High","O14647","Chromodomain-helicase-DNA-binding protein 2 [OS=Homo sapiens]",13,23,44,18,1828,211.2,8.1,79.25,"cell organization and biogenesis;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CHD2","ENSG00000173575","Prion disease pathway; Male infertility","","",1442.6,1514.5,1433.1,1670.5,1573.7,1733.9,0.8819027339748096,-0.18130854675787256,0.02113422739028668,1.6750136241665592,0.11905919730401039,0.9242370497837118,1386]
["High","O14653-1","Golgi SNAP receptor complex member 2 [OS=Homo sapiens]",24,4,4,4,212,24.8,8.06,11.17,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","GOSR2","ENSG00000108433","","COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER","SNARE interactions in vesicular transport",254.3,267.6,264.4,224.8,270.8,251.3,1.0527513723390012,0.07416475616754457,0.3988444919253628,0.39919640121319927,0.6262171310985789,0.20327505578678878,4973]
["High","O14656","Torsin-1A [OS=Homo sapiens]",19,5,10,5,332,37.8,6.99,14.35,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TOR1A","ENSG00000136827","","Cargo recognition for clathrin-mediated endocytosis","",282.4,309.8,322.5,299.3,303.9,308.5,1.0032905561039815,4.7394754874539565E-3,0.9382404238753352,0.02768585950675155,0.9695316608812358,0.013438004097912131,7556]
["Low","O14657","Torsin-1B [OS=Homo sapiens]",2,1,2,1,336,38,8.54,4.48,"cell organization and biogenesis;stress response;other biological processes","other membranes;ER/Golgi;nucleus","cytoskeletal activity;other molecular function","TOR1B","ENSG00000136816","","Cargo recognition for clathrin-mediated endocytosis","",148.3,148.5,186.3,146.2,131.4,150.4,1.1287383177570094,0.17471105614356766,0.25648310517403594,0.5909412370681205,0.4854836570179085,0.313825385295429,4125]
["High","O14662-2","Isoform A of Syntaxin-16 [OS=Homo sapiens]",27,6,11,6,304,34.8,6.2,24.64,"","","","STX16","","","","",672.9,647.9,608.2,508,468.4,478.1,1.3262289446545206,0.4073298469487972,2.0832122050181475E-3,2.6812664886819357,0.03791543332583146,1.4211839762080247,429]
["Medium","O14668-1","Transmembrane gamma-carboxyglutamic acid protein 1 [OS=Homo sapiens]",3,1,2,1,218,24.9,5.19,4.45,"","non-structural extracellular;plasma membrane;other membranes","other molecular function","PRRG1","ENSG00000130962; ENSNLEG00000000909","","","",110.9,115.9,90.4,84.7,84.7,83.4,1.2547468354430382,0.3273963075268758,0.05151062149894194,1.2881032101284935,0.19170397171770195,0.7173688893273973,2098]
["High","O14672","Disintegrin and metalloproteinase domain-containing protein 10 [OS=Homo sapiens]",28,17,39,17,748,84.1,7.77,86.88,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM10","ENSG00000137845","Alzheimer's disease and miRNA effects; Copper homeostasis; Canonical and non-canonical Notch signaling; VEGFA-VEGFR2 signaling pathway; 3q29 copy number variation syndrome; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Hypertrophy model","Amyloid fiber formation; Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus","Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection",1286.9,1221,1260.6,1402.5,1461.3,1422.4,0.8792170220708319,-0.18570877704943445,0.002593473053682714,2.586118259988769,0.04201211120986438,1.3766254935689832,482]
["High","O14681","Etoposide-induced protein 2.4 homolog [OS=Homo sapiens]",8,3,3,3,340,38.9,9.72,7.6,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EI24","ENSG00000149547","miRNA regulation of p53 pathway in prostate cancer","","p53 signaling pathway",265.9,292.1,252.1,250.2,254.4,259.3,1.0604791203037047,0.08471621603033161,0.26941182852233436,0.5695833405016526,0.5001349398721794,0.30091280419331956,4206]
["High","O14682","Ectoderm-neural cortex protein 1 [OS=Homo sapiens]",3,2,4,2,589,66.1,6.84,7.6,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity","ENC1","ENSG00000171617","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","",200.8,234.2,211.7,226.9,189.6,188,1.0698097601323409,0.09735427091139108,0.4307723493609523,0.36575218119893027,0.6528475356774681,0.18518823089205053,5152]
["High","O14683","Tumor protein p53-inducible protein 11 [OS=Homo sapiens]",18,3,12,3,189,21,9.55,34.84,"other biological processes","other membranes","","TP53I11","ENSG00000175274","","","",393.3,398.6,385,363.4,387.5,368.9,1.050991248437221,0.07175065608525928,0.08347439514445935,1.0784467191603884,0.25419971813102127,0.5948249353485329,2564]
["High","O14686-1","Histone-lysine N-methyltransferase 2D [OS=Homo sapiens]",5,20,31,20,5537,593,5.58,54.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KMT2D","ENSG00000167548","Histone modifications; 16p11.2 proximal deletion syndrome","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Lysine degradation; Metabolic pathways; Cushing syndrome",922.4,927.4,932.4,1043.9,1007.9,1040.7,0.8996604688763137,-0.1525474626554126,9.5230742610350957E-4,3.021222829023651,0.02753931993709705,1.560046788524003,270]
["High","O14717-1","tRNA (cytosine(38)-C(5))-methyltransferase [OS=Homo sapiens]",7,2,2,2,391,44.6,6.09,4.6,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT2; TRDMT1","ENSG00000107614","","tRNA modification in the nucleus and cytosol","",14.4,12.9,16.3,14.5,12.1,16.5,1.011600928074246,0.016640265687828244,0.9224355565788007,0.035063964897716286,0.9612140432092988,0.017179892837181937,7493]
["High","O14727","apoptotic protease-activating factor 1 [OS=Homo sapiens]",4,5,6,5,1248,141.7,6.4,12.17,"stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;other cell component","enzyme regulator activity;other molecular function","APAF1","ENSG00000120868","miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkinson's disease pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; p53 transcriptional gene network; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response","Neutrophil degranulation; Transcriptional Regulation by E2F6; Formation of apoptosome; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of the apoptosome activity","Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Legionellosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Small cell lung cancer; Lipid and atherosclerosis",267.1,248.5,243.9,274.7,288.6,287.1,0.8931091251175918,-0.16309163214165884,0.022172512264200646,1.6541850962104787,0.12089593279251303,0.9175883095236801,1432]
["High","O14730","serine/threonine-protein kinase RIO3 [OS=Homo sapiens]",8,4,5,4,519,59.1,5.76,6.55,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;other cell component","kinase activity;other molecular function","RIOK3","ENSG00000101782","","Major pathway of rRNA processing in the nucleolus and cytosol","",148.2,148.8,142.1,156.3,170.7,169.8,0.8838566827697263,-0.1781156390939399,0.0199046633254004,1.7010451638300652,0.11632905033287899,0.9343118173109566,1336]
["High","O14732-1","inositol monophosphatase 2 [OS=Homo sapiens]",17,4,6,4,288,31.3,6.61,13.79,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA2","ENSG00000141401","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",450,447.9,427.2,423.4,430.8,440.3,1.023638470451912,0.033706272973835744,0.309298004632624,0.5096228817421686,0.5433068211859456,0.26495484238976574,4445]
["High","O14733","dual specificity mitogen-activated protein kinase kinase 7 [OS=Homo sapiens]",15,5,15,5,419,47.5,9.16,22,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAP2K7","ENSG00000076984","MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; MAPK signaling pathway; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; Alzheimer's disease; ErbB signaling pathway; Toll-like receptor signaling pathway","FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Uptake and function of anthrax toxins","MAPK signaling pathway; ErbB signaling pathway; Protein processing in endoplasmic reticulum; Osteoclast differentiation; Tight junction; Toll-like receptor signaling pathway; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Relaxin signaling pathway; Alcoholic liver disease; Alzheimer disease; Huntington disease; Pathways of neurodegeneration; Salmonella infection; Yersinia infection; Hepatitis B; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Chemical carcinogenesis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",726.6,652.9,692.5,719.2,743.3,785.6,0.9216671856234153,-0.11768220793265638,0.11127338815578554,0.9536086879474216,0.3013606017066852,0.520913525676994,2883]
["High","O14734","Acyl-coenzyme A thioesterase 8 [OS=Homo sapiens]",22,4,5,4,319,35.9,7.56,17.22,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOT8","ENSG00000101473","","Peroxisomal protein import; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids","Primary bile acid biosynthesis; Metabolic pathways; Peroxisome",86.2,74,88.1,69.5,96.1,78.4,1.0176229508196721,0.02520311372659223,0.8809122801268016,0.055067335803165876,0.9400250216249919,0.02686058617792357,7317]
["High","O14735","CDP-diacylglycerol--inositol 3-phosphatidyltransferase [OS=Homo sapiens]",19,4,6,4,213,23.5,8.03,11.57,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","CDIPT","ENSG00000103502","Glycerolipids and glycerophospholipids; 16p11.2 proximal deletion syndrome","Synthesis of PI","Inositol phosphate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system",524,526.8,514.9,483.9,454.7,449.6,1.1278634202564473,0.17359237372182879,6.303268950119921E-3,2.2004341618477237,0.06325954236829864,1.1988739541787772,778]
["High","O14744","Protein arginine N-methyltransferase 5 [OS=Homo sapiens]",39,22,81,22,637,72.6,6.29,162.25,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","PRMT5","ENSG00000100462","Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis","RMTs methylate histone arginines; snRNP Assembly; Regulation of TP53 Activity through Methylation","",3331.3,3410.1,3551.5,3411.4,3594.4,3567.6,{"$f":"AVERAGE(T194:V194)/AVERAGE(W194:Y194)","v":0.9734711634857284},{"$f":"LOG(Z194,2)","v":-0.038789851342212724},{"$f":"TTEST(T194:V194,W194:Y194,2,2)","v":0.33834277587805967},{"$f":"-LOG10(AB194)","v":0.4706430919152221},{"$f":"AB194*7808/AF194","v":0.570578918802568},{"$f":"-LOG10(AD194)","v":0.24368427827453984},4630]
["High","O14745","Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [OS=Homo sapiens]",44,13,23,13,358,38.8,5.77,51.87,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function","SLC9A3R1","ENSG00000109062","","","Tight junction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human papillomavirus infection",960.5,953.6,874.7,1068.7,764.2,723.6,1.0908664189321338,0.12547444855137938,0.5284915577045068,0.27696194586200734,0.7281563583124738,0.13777535384486797,5667]
["High","O14757","Serine/threonine-protein kinase Chk1 [OS=Homo sapiens]",22,9,14,9,476,54.4,8.25,28.33,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CHEK1","ENSG00000149554","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; DNA damage response","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis",592.6,607.1,666.7,791,950.8,885.6,0.7103600517621983,-0.49337764318960814,0.007970572820642395,2.0985104660688028,0.07080117472534223,1.1499595364839392,879]
["High","O14763","Tumor necrosis factor receptor superfamily member 10B [OS=Homo sapiens]",11,3,7,3,440,47.8,5.55,2.63,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TNFRSF10B","ENSG00000120889","miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer; miRNA regulation of p53 pathway in prostate cancer; Unfolded protein response; DNA damage response","Cell surface interactions at the vascular wall; Regulation by c-FLIP; RIPK1-mediated regulated necrosis; CASP8 activity is inhibited; TP53 Regulates Transcription of Death Receptors and Ligands; Dimerization of procaspase-8; TRAIL  signaling","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; p53 signaling pathway; Apoptosis; Necroptosis; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Salmonella infection; Influenza A; Lipid and atherosclerosis",39.4,44.1,39.3,45.2,53.9,50.2,0.8225050234427326,-0.2819036047643622,0.04125684324820619,1.3845040049700579,0.17116547932093196,0.7665838194026607,1882]
["High","O14772","fucose-1-phosphate guanylyltransferase [OS=Homo sapiens]",7,4,5,3,594,66.6,6.48,10.02,"","","other molecular function","FPGT","ENSG00000254685","","","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",126,125.7,127.9,127.6,134.8,121.8,0.9880270692347737,-0.017377526644417544,0.7088333310519046,0.14945586906742692,0.8489907422692548,0.07109704544897846,6519]
["High","O14773","Tripeptidyl-peptidase 1 [OS=Homo sapiens]",20,7,15,7,563,61.2,6.48,42.56,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TPP1","ENSG00000166340","VEGFA-VEGFR2 signaling pathway","XBP1(S) activates chaperone genes","Lysosome",1040.2,987.8,1128.5,1006.9,1079.6,1056.7,1.0042313565792824,0.006091678191664082,0.928361842637937,0.032282718143245445,0.96430082044925,0.015787463730705123,7517]
["High","O14775","Guanine nucleotide-binding protein subunit beta-5 [OS=Homo sapiens]",8,2,2,2,395,43.5,6.46,6.36,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","GNB5","ENSG00000069966","Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells","G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits","Ras signaling pathway; Chemokine signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Relaxin signaling pathway; Morphine addiction; Alcoholism; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",40.4,34,31.9,34.8,42,35.7,0.944888888888889,-0.08178340457329457,0.577753477739384,0.23825743164118848,0.7636870076500949,0.11708459784033372,5907]
["High","O14776-1","Transcription elongation regulator 1 [OS=Homo sapiens]",26,34,100,34,1098,123.8,8.65,216.66,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","TCERG1","ENSG00000113649; ENSGGOG00000003329; ENSPTRG00000017375","","","Spliceosome",6925.3,6517.7,6587.7,8191.5,7588,7916,0.8453377223523455,-0.24240026470812007,0.004743052631314243,2.323942056169859,0.054461404331325895,1.26391116421746,680]
["High","O14777","Kinetochore protein NDC80 homolog [OS=Homo sapiens]",36,20,40,20,642,73.9,5.6,78.95,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NDC80","ENSG00000080986","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",2350.6,2193.4,2254.3,2582.1,2464.5,2445.5,0.907395790232378,-0.14019612841554427,0.020942007249419928,1.6789816944065363,0.11831779493738843,0.9269499327860805,1382]
["High","O14782","Kinesin-like protein KIF3C [OS=Homo sapiens]",6,5,5,2,793,89.4,8.22,13.05,"transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3C","ENSG00000084731","","Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",59.6,52.6,60.1,64.6,71,64.1,0.8627941912869305,-0.2129116312190243,0.04983089767750324,1.3025012891710135,0.1881429637649639,0.7255120189342829,2068]
["High","O14787-2","Isoform 2 of Transportin-2 [OS=Homo sapiens]",34,24,72,12,887,100.3,4.98,136.86,"","","","TNPO2","","","","",1156,1328.6,1207.8,1127,1119.9,1157.6,1.08456454692319,0.11711591631577674,0.14114883755478652,0.8503226941774981,0.34505013263236484,0.4621178013213267,3194]
["High","O14795","Protein unc-13 homolog B [OS=Homo sapiens]",9,12,19,11,1591,180.6,5.99,27.15,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","UNC13B","ENSG00000198722","Synaptic vesicle pathway; 16p11.2 proximal deletion syndrome; Monoamine transport","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle","Synaptic vesicle cycle",594.5,586.9,592,613.9,585.2,597,0.9873615054841045,-0.018349695432988027,0.4297844584589428,0.36674929318975236,0.6523633459656737,0.1855104484472826,5144]
["Medium","O14798","Tumor necrosis factor receptor superfamily member 10C [OS=Homo sapiens]",4,1,1,1,259,27.4,4.82,2.91,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TNFRSF10C","ENSG00000173535","Apoptosis modulation and signaling; VEGFA-VEGFR2 signaling pathway","TP53 Regulates Transcription of Death Receptors and Ligands","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor",74.4,80.2,78.1,85.1,67.6,81.5,0.9935952177625963,-0.009269865095866187,0.9331278031402032,0.030058870297014637,0.9665510595540868,0.014775198751965375,7538]
["High","O14802","DNA-directed RNA polymerase III subunit RPC1 [OS=Homo sapiens]",28,29,60,28,1390,155.5,8.48,110.91,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3A","ENSG00000148606","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",2035,2100.2,2187.5,2155.8,2243.5,2177,0.9614372823624227,-0.05673534587744135,0.1758794664892211,0.7547848604342892,0.38825752738135094,0.4108801155904053,3537]
["High","O14818-1","Proteasome subunit alpha type-7 [OS=Homo sapiens]",66,16,112,16,248,27.9,8.46,245.84,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","HEL-S-276; PSMA7","ENSG00000101182","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",4651.1,4895.1,4915.5,4898.8,5158.8,4812.4,0.9725420309347679,-0.0401674936205903,0.368357515591357,0.4337304648166798,0.5994446606372063,0.2222509037898562,4798]
["Low","O14827","Ras-specific guanine nucleotide-releasing factor 2 [OS=Homo sapiens]",1,1,1,1,1237,140.7,7.53,0,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","RASGRF2","ENSG00000113319","MAPK signaling pathway; Ras signaling","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor","MAPK signaling pathway; Ras signaling pathway",92.6,99.8,109.5,93.3,103.9,93.2,1.0396005509641872,0.05602930351787432,0.5606303409370186,0.25132340221441624,0.7521308766385293,0.12370658220566941,5820]
["High","O14828","Secretory carrier-associated membrane protein 3 [OS=Homo sapiens]",41,9,31,9,347,38.3,7.64,88.4,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCAMP3","ENSG00000116521; ENSG00000263290","","","",706.5,737,673.3,671.9,644.6,688.5,1.0557605985037406,0.0782827300490317,0.1716287390493661,0.7654099882500534,0.38463754147458395,0.4149483299270436,3484]
["High","O14832","Phytanoyl-CoA dioxygenase, peroxisomal [OS=Homo sapiens]",10,4,8,4,338,38.5,8.47,16,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","PHYH","ENSG00000107537","","TYSND1 cleaves peroxisomal proteins; Alpha-oxidation of phytanate","Peroxisome",699.2,686.1,696.8,713.8,677.9,671.2,1.0093072858597123,0.013365473051051733,0.6674780096404553,0.1755630377523353,0.8209937459471763,0.08566015117651049,6348]
["High","O14841","5-oxoprolinase [OS=Homo sapiens]",10,9,11,9,1288,137.4,6.58,25.59,"other metabolic processes","cytosol","other molecular function","OPLAH","ENSG00000178814","Glutathione metabolism","Glutathione synthesis and recycling; Defective OPLAH causes OPLAHD","Glutathione metabolism; Metabolic pathways",156.6,155.8,164.4,134.7,151.1,147.1,1.1014091014091014,0.1393504352498073,0.06062165079303268,1.2173722414995187,0.2093471248969479,0.6791329991862429,2261]
["High","O14867","Transcription regulator protein BACH1 [OS=Homo sapiens]",29,17,28,17,736,81.9,5.05,55.25,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH1","ENSG00000156273","Integrated cancer pathway; Ferroptosis","Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity","",1171,1168.3,1196.2,1001.9,905.7,922.1,1.249425734176768,0.32126515022885255,1.6194277606229866E-3,2.79063842021481,0.03284283624660852,1.4835593450646756,385]
["Medium","O14874","[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial [OS=Homo sapiens]",4,1,1,1,412,46.3,8.82,2.17,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","BCKDK","ENSG00000103507","Thiamine metabolic pathways","Branched-chain amino acid catabolism","",12.3,16.4,11,12.9,15.3,16.6,0.8861607142857142,-0.1743597249146465,0.4336169865613866,0.36289371303475765,0.6546174460694715,0.1840124245844787,5172]
["High","O14880","Microsomal glutathione S-transferase 3 [OS=Homo sapiens]",28,3,20,3,152,16.5,9.38,43.62,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","MGST3","ENSG00000143198","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II","Aflatoxin activation and detoxification; Glutathione conjugation","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",494.8,530.7,537.1,440.3,514.9,481.5,1.0876313774622397,0.12118967789512011,0.17214672955934082,0.7641012236001635,0.38458416721010963,0.4150085990232283,3495]
["High","O14893","Gem-associated protein 2 [OS=Homo sapiens]",29,7,13,7,280,31.6,5.58,27.35,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","GEMIN2","ENSG00000092208","","snRNP Assembly","",416.5,415.3,397.4,444.1,422.3,454.6,0.9305071915215745,-0.10391079454122785,0.05420689112941321,1.2659454996380066,0.1975022892853282,0.7044278660211999,2143]
["Medium","O14896-1","Interferon regulatory factor 6 [OS=Homo sapiens]",3,1,1,1,467,53.1,5.33,0,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IRF6","ENSCANG00000037044; ENSCATG00000039683; ENSG00000117595; ENSGGOG00000006214; ENSMFAG00000033961; ENSMMUG00000022065; ENSMNEG00000040867; ENSNLEG00000001962; ENSPPAG00000032756; ENSPPYG00000000253; ENSPTRG00000001941","Apoptosis; Primary focal segmental glomerulosclerosis (FSGS); Hypothetical craniofacial development pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway","Interferon gamma signaling; Interferon alpha/beta signaling","",10.6,15,10.4,14,8.8,13.1,1.0027855153203342,4.0130625066233045E-3,0.9886225338971009,0.004969494790036053,0.9930740698145586,0.003018357836887881,7773]
["High","O14907","Tax1-binding protein 3 [OS=Homo sapiens]",26,3,6,3,124,13.7,8.48,13.43,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TAX1BP3","ENSG00000213977","","RHO GTPases Activate Rhotekin and Rhophilins","",267.2,277.6,258.1,190.8,192.8,205.6,1.3626951799049558,0.4464628830375798,6.1647835166798212E-4,3.2100821695406134,0.02218185700379541,1.6540020987305077,217]
["High","O14908-1","PDZ domain-containing protein GIPC1 [OS=Homo sapiens]",32,8,18,8,333,36,6.28,43.29,"cell-cell signaling;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GIPC1","ENSG00000123159","VEGFA-VEGFR2 signaling pathway","","",1229.6,1326.6,1225.8,1317.1,1243,1299,0.9800212484776245,-0.02911506531159135,0.5538020590783195,0.2566454338474152,0.7487595631659772,0.12565761775296172,5775]
["High","O14910","Protein lin-7 homolog A [OS=Homo sapiens]",15,4,11,2,233,26,8.72,19.9,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","LIN7A","ENSG00000111052","","Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle","",440.9,461.7,401.9,500.7,440.3,421.6,0.9573609276383385,-0.06286516772322959,0.5488043179446283,0.26058248029666187,0.7452285416542012,0.12771052032765703,5750]
["High","O14920-1","Inhibitor of nuclear factor kappa-B kinase subunit beta [OS=Homo sapiens]",15,6,9,6,756,86.5,5.78,13.02,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","IKBKB","ENSG00000104365","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",151.2,147.4,162.3,170.1,187.2,181.4,0.8555782439205497,-0.22502829750244627,0.018180906742037466,1.7403844608696435,0.11168884330592332,0.9519902067650162,1271]
["High","O14924","Regulator of G-protein signaling 12 [OS=Homo sapiens]",4,5,5,4,1447,156.3,7.44,4.95,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","RGS12","ENSG00000159788","","G alpha (i) signalling events","",25.2,12.6,10.4,18.9,19.1,15,0.9094339622641509,-0.13695921322060006,0.7556174977099253,0.1216979937479812,0.8761302973149832,0.05743130114141558,6734]
["High","O14929","histone acetyltransferase type B catalytic subunit [OS=Homo sapiens]",35,10,88,10,419,49.5,5.69,190.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","HAT1","ENSG00000128708","Ethanol effects on histone modifications","HATs acetylate histones","Neutrophil extracellular trap formation; Alcoholism",2862.4,3010.5,3038.8,2873.4,3083.5,2958.7,0.9995625644936967,-6.31224105638178E-4,0.9881011642662852,0.005198588981759589,0.9926780610642248,0.003191576250869083,7772]
["Medium","O14933","Ubiquitin/ISG15-conjugating enzyme E2 L6 [OS=Homo sapiens]",5,1,2,1,153,17.8,7.88,4.52,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UBE2L6","ENSG00000156587","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome","Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration",100.5,103,94,140.9,104.2,100.4,0.8610709117221418,-0.21579604219295273,0.2918172154329722,0.5348890909655173,0.5247602068403148,0.28003910542528315,4342]
["High","O14936","peripheral plasma membrane protein CASK [OS=Homo sapiens]",29,23,54,23,926,105.1,6.43,119,"cell adhesion;protein metabolism;other metabolic processes;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CASK","ENSG00000147044","Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions","",3116.6,3162.4,3314.7,3035,3239,3119,1.021366975407218,0.03050131722103768,0.47135296752935946,0.3266537543562532,0.6840750874478139,0.164896225364007,5380]
["High","O14939-1","Phospholipase D2 [OS=Homo sapiens]",5,5,6,5,933,105.9,7.64,8.76,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","PLD2","ENSG00000129219","Ras signaling; EGF/EGFR signaling pathway","Role of phospholipids in phagocytosis; RAC1 GTPase cycle; RAC2 GTPase cycle; Synthesis of PG; Synthesis of PA","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways; Ras signaling pathway; cAMP signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Endocytosis; Fc gamma R-mediated phagocytosis; Glutamatergic synapse; GnRH signaling pathway; Parathyroid hormone synthesis, secretion and action; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Choline metabolism in cancer",383.6,372.1,375.8,312.2,324.9,313.7,1.1900504838031132,0.2510227762118201,3.2895439230370922E-4,3.48286431038998,0.017123172634049076,1.766415764787026,150]
["High","O14949","Cytochrome b-c1 complex subunit 8 [OS=Homo sapiens]",29,3,6,3,82,9.9,10.08,11.63,"other metabolic processes;transport;developmental processes","other membranes;mitochondrion","","UQCRQ","ENSG00000164405","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly","Respiratory electron transport","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",669.9,493.3,518.6,497.1,553.4,533.5,1.0617424242424243,0.08643381478667812,0.601332581207176,0.22088526471403455,0.7794164664783583,0.10823042324804334,6024]
["High","O14950","Myosin regulatory light chain 12B [OS=Homo sapiens]",40,6,23,6,172,19.8,4.84,56.04,"other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL12B","ENSG00000118680","Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion","RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Salmonella infection",569.4,827.7,522.7,599.7,449.7,473.8,1.2603728991596637,0.33385063862684605,0.27895240153429074,0.5544698953448434,0.5093686508839435,0.29296778722294836,4276]
["High","O14964","Hepatocyte growth factor-regulated tyrosine kinase substrate [OS=Homo sapiens]",24,16,34,16,777,86.1,6.16,73.13,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","HGS","ENSG00000185359","TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway","Lysosome Vesicle Biogenesis; Ub-specific processing proteases; Cargo recognition for clathrin-mediated endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle","Endocytosis; Phagosome",1532.4,1596.1,1615.9,1599.1,1499.7,1559.4,1.0185050019320765,0.02645306547305165,0.4951369168961343,0.3052746919141822,0.7029143722045486,0.1530975767497906,5500]
["High","O14965","Aurora kinase A [OS=Homo sapiens]",16,5,11,5,403,45.8,9.39,24.71,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AURKA","ENSG00000087586","Gastric cancer network 1; EGF/EGFR signaling pathway","Regulation of TP53 Activity through Phosphorylation; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA","Oocyte meiosis; Progesterone-mediated oocyte maturation",252,229.9,239.6,250.8,257.3,258.9,0.940677966101695,-0.08822718301173522,0.09148370626969701,1.0386562491825564,0.2686366222466319,0.5708347818554881,2659]
["High","O14966-1","Ras-related protein Rab-7L1 [OS=Homo sapiens]",23,4,5,4,203,23.1,7.18,10.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB29; RAB7L1","ENSG00000117280; ENSNLEG00000029152; ENSPPAG00000013675; ENSPPYG00000000298; ENSPTRG00000001905","","RAB geranylgeranylation","",434.9,438.9,463.2,455.2,493.6,480.5,0.9354229343035052,-0.09630929431062307,0.09822619840847163,1.0077726638751654,0.2806257435687327,0.5518724909091907,2733]
["High","O14967","calmegin [OS=Homo sapiens]",28,13,34,12,610,70,4.69,44.08,"cell organization and biogenesis;stress response;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","CLGN","ENSG00000153132","","","",1190.2,1178,1260.3,1226.7,1270.6,1217.4,0.9767948959539128,-0.033872433056330496,0.39866918272854807,0.39938733416005534,0.6264457594575374,0.20311652624695267,4969]
["High","O14972","Down syndrome critical region protein 3 [OS=Homo sapiens]",8,2,3,2,297,33,7.68,5.94,"transport","other cytoplasmic organelle","","VPS26C","ENSG00000157538","","","",69.1,72.1,78.2,76.3,77.2,79.5,0.9416309012875534,-0.08676642913845001,0.18588427439378105,0.7307573495120353,0.4009349211233819,0.3969261153865655,3620]
["High","O14974","Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",49,45,141,44,1030,115.2,5.4,267.69,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12A","ENSG00000058272","Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton","Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","cGMP-PKG signaling pathway; cAMP signaling pathway; Vascular smooth muscle contraction; Focal adhesion; Platelet activation; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer",6819,6879.7,6640.1,6996.8,6526,6694.9,1.0059898010159418,0.008615678803171784,0.8078145102904684,0.09268835012309455,0.9054573207504992,0.04313201558667658,6966]
["Medium","O14975","very long-chain acyl-CoA synthetase [OS=Homo sapiens]",2,1,1,1,620,70.3,8.51,0,"other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC27A2","ENSG00000140284","PPAR signaling pathway","Peroxisomal protein import; Neutrophil degranulation; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Alpha-oxidation of phytanate; Synthesis of bile acids and bile salts via 24-hydroxycholesterol","PPAR signaling pathway; Peroxisome; Insulin resistance",20.9,17.5,24.8,19.3,27.1,21,0.9376854599406528,-0.0928240330047556,0.6816715728225018,0.16642481664221054,0.8302123912959123,0.08081078886730701,6411]
["High","O14976","Cyclin-G-associated kinase [OS=Homo sapiens]",20,15,36,15,1311,143.1,5.73,66.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","GAK","ENSG00000178950","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","",1021.6,927.1,1015.6,1031.2,1100.1,1056.3,0.9299472957711129,-0.10477914026267243,0.1116455210955554,0.9521586949167885,0.30174047376742696,0.5203664321023501,2889]
["High","O14979-1","Heterogeneous nuclear ribonucleoprotein D-like [OS=Homo sapiens]",29,14,153,12,420,46.4,9.57,280.03,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPDL; HNRPDL","ENSG00000152795; ENSPPAG00000043177; ENSPTRG00000016217","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",4823.8,4343.6,4487.1,5138.9,5004.2,5184.7,0.8908323438458229,-0.1667741552407042,0.02152500786239972,1.6670566812403382,0.11936595269148936,0.9231195313877963,1408]
["High","O14980","Exportin-1 [OS=Homo sapiens]",44,39,187,39,1071,123.3,6.06,400.66,"transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPO1","ENSG00000082898","eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MAPK6/MAPK4 signaling; Deactivation of the beta-catenin transactivating complex; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Heme signaling; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Influenza A; Human T-cell leukemia virus 1 infection",7892,7935.5,8391.4,8362.6,9213.2,8926.3,0.9138483365469151,-0.12997334127486215,0.062202923752625566,1.2061892014861992,0.21273781369272904,0.6721553083177991,2283]
["High","O14981","TATA-binding protein-associated factor 172 [OS=Homo sapiens]",10,13,29,13,1849,206.8,6.52,67.1,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BTAF1","ENSG00000095564","","","",885,968.6,923.8,869.1,845.2,868.7,1.0752613240418116,0.10468732500768449,0.06331587441505873,1.1984873909850837,0.21466363327519697,0.6682415242906793,2303]
["High","O14994","Synapsin-3 [OS=Homo sapiens]",5,2,2,2,580,63.3,9.39,2.45,"cell-cell signaling;transport;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","SYN3","ENSG00000185666","Synaptic vesicle pathway","Serotonin Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle","",102.7,70,94,132.8,147.2,123.7,0.6606390884320039,-0.598065761929584,0.018670365171013076,1.7288471876639382,0.11239646203181966,0.9492473590893828,1297]
["High","O15013","rho guanine nucleotide exchange factor 10 [OS=Homo sapiens]",12,11,18,11,1369,151.5,5.68,26.01,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity","ARHGEF10","ENSG00000104728; ENSG00000274726","","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events","",682.2,620.6,682.1,626.4,654.6,680.4,1.011981237891302,0.0171825427475455,0.7763066155681111,0.10996671282861817,0.8865587325370501,0.05229248807002077,6837]
["High","O15014","zinc finger protein 609 [OS=Homo sapiens]",10,15,23,14,1411,151.1,8.03,37.1,"developmental processes;other biological processes","nucleus","other molecular function","ZNF609","ENSG00000180357","","","",1129.9,1139.2,1102.7,1305.5,1080.6,1149.2,0.9537521568183747,-0.0683136804210279,0.46435569528534587,0.33314922349630705,0.6783328847124379,0.16855712838246847,5345]
["High","O15015","Zinc finger protein 646 [OS=Homo sapiens]",6,10,10,9,1829,200.6,7.33,23.91,"","","","","","","","",493.1,472.2,498.9,517.1,493.9,510.6,0.9622765509989484,-0.055476521663869204,0.1469093154163659,0.8329506650289659,0.35272691721125,0.45256139729236106,3252]
["High","O15020","Spectrin beta chain, non-erythrocytic 2 [OS=Homo sapiens]",26,51,98,39,2390,271.2,6.11,197.61,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTBN2","ENSG00000173898","","MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","Spinocerebellar ataxia; Pathways of neurodegeneration",1905.4,1795,1937,1769.7,1840,1770.8,1.0477464919617134,0.06728969108159656,0.1549507043887661,0.8098064451655248,0.3631017706685131,0.4399716332416394,3332]
["High","O15027-5","Isoform 5 of Protein transport protein Sec16A [OS=Homo sapiens]",16,27,61,27,2201,235.6,5.67,122.53,"","","","","","","","",2507,2285.8,2380.4,2402.1,2268.4,2306.2,1.0281651783794632,0.040072057222312225,0.43418117163162606,0.36232901375535614,0.6547096539396942,0.18395125519557398,5178]
["High","O15031","Plexin-B2 [OS=Homo sapiens]",15,19,27,19,1838,205,6.24,58.63,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PLXNB2","ENSG00000196576","","","Axon guidance",885,990.2,941.8,884.6,871.9,852.3,1.0798068077276908,0.11077321751382754,0.0946326734160977,1.0239588907187778,0.2733599385989237,0.5632651317588678,2703]
["High","O15037","protein KHNYN [OS=Homo sapiens]",8,3,4,3,678,74.5,7.02,11.83,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHNYN","ENSG00000100441","","","",429.8,157.4,206.8,161.1,161.8,161.5,1.6391412056151942,0.7129401423359916,0.28553379626071557,0.5443424805499198,0.5166739006265741,0.28678347594251274,4315]
["Medium","O15040","Tectonin beta-propeller repeat-containing protein 2 [OS=Homo sapiens]",1,1,1,1,1411,153.8,5.55,2.2,"other metabolic processes;transport","other cell component","","TECPR2","ENSG00000196663","","","",24.9,21,27.7,23.7,18.5,17.7,1.2287145242070114,0.29714976326822695,0.16652979453241112,0.7785080537888367,0.3771069129086619,0.4235355062828764,3448]
["High","O15042","U2 snRNP-associated SURP motif-containing protein [OS=Homo sapiens]",34,28,87,28,1029,118.2,8.47,154.17,"RNA metabolism OR transcription;other metabolic processes","nucleus","","U2SURP","ENSG00000163714","","mRNA Splicing - Major Pathway","Spliceosome",3832.5,3889,3907.5,4470.7,4276.8,4403.2,0.8842875284205404,-0.1774125528952165,1.152751439348074E-3,2.938264326839602,0.029607510652729478,1.52859810578972,304]
["High","O15047","Histone-lysine N-methyltransferase SETD1A [OS=Homo sapiens]",11,13,20,12,1707,185.9,5.14,42.36,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETD1A","ENSG00000099381","Histone modifications","PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Lysine degradation; Metabolic pathways",632.6,662.3,573.3,645.2,598,633.4,0.9955238196738784,-0.006472259489790836,0.9295608781831639,0.03172216243513497,0.9646479714053886,0.01563114465484083,7524]
["Low","O15050","TPR and ankyrin repeat-containing protein 1 [OS=Homo sapiens]",0,1,1,1,2925,336,6.76,0,"","","","TRANK1","ENSG00000168016","","","",51,56.1,49,55.3,47.1,43.3,1.0713795470144132,0.09946965991339628,0.4478577441842624,0.3488599117310554,0.6655640020157443,0.1768101755224715,5254]
["High","O15054","Lysine-specific demethylase 6B [OS=Homo sapiens]",2,2,2,2,1643,176.5,8.54,2.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6B","ENSG00000132510","Pathways affected in adenoid cystic carcinoma; Vitamin D-sensitive calcium signaling in depression","Oxidative Stress Induced Senescence; HDMs demethylate histones","",49.2,49.3,49.4,58.3,61.6,53,0.8554077501445924,-0.2253158165432139,0.029215793090213403,1.534382319861046,0.14003493704627762,0.85376359951092,1629]
["High","O15056","Synaptojanin-2 [OS=Homo sapiens]",3,5,5,5,1496,165.4,7.34,10.21,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ2","ENSG00000078269","","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",197.6,233.5,208.3,213.9,228,238.3,0.9400176418700382,-0.08924026192732162,0.3471345183451802,0.45950219882795984,0.579646347142679,0.23683689665912697,4676]
["High","O15061-1","Synemin [OS=Homo sapiens]",3,3,3,3,1565,172.7,5.16,2.25,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SYNM","ENSG00000182253","","","",27.1,23.7,29.2,24.1,26.1,20.7,1.1283497884344145,0.17421437253520833,0.248492219684404,0.6046872045202984,0.4780062210632733,0.32056645117894844,4059]
["High","O15063","Uncharacterized protein KIAA0355 [OS=Homo sapiens]",4,3,3,3,1070,115.9,7.15,9.75,"signal transduction","cytosol;other cell component","other molecular function","GARRE1","ENSG00000166398","","RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",120.4,107.2,100.8,110.1,116.5,106,0.9873722188815395,-0.018334041509464116,0.8407092199070918,0.07535418972710127,0.9229833505391694,0.034806133030623174,7112]
["High","O15066","Kinesin-like protein KIF3B [OS=Homo sapiens]",12,9,10,6,747,85.1,7.69,24.97,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3B","ENSG00000101350","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",522.4,536.3,518.4,577.9,605.5,615.9,0.8765075307063855,-0.1901616086189389,0.004147068481048648,2.3822587930189134,0.05131586481779374,1.2897483476044123,631]
["High","O15067","Phosphoribosylformylglycinamidine synthase [OS=Homo sapiens]",35,36,100,36,1338,144.6,5.76,222.91,"other metabolic processes;other biological processes","cytosol","other molecular function","PFAS","ENSG00000178921","","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Metabolic pathways",4495.5,4516.3,4444,4922.7,4720.6,4724.6,0.9365182107336493,-0.09462104673010577,0.012272030193026978,1.9110835848937189,0.09048159749495244,1.0434397403425686,1059]
["High","O15068","Guanine nucleotide exchange factor DBS [OS=Homo sapiens]",4,3,3,3,1137,128,6.43,6.81,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","MCF2L","ENSG00000126217","","CDC42 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RHOB GTPase cycle","",75.9,62.3,70.9,81,80.3,75.6,{"$f":"AVERAGE(T258:V258)/AVERAGE(W258:Y258)","v":0.8826509075559308},{"$f":"LOG(Z258,2)","v":-0.18008513665065196},{"$f":"TTEST(T258:V258,W258:Y258,2,2)","v":0.09843319939097545},{"$f":"-LOG10(AB258)","v":1.0068583987176707},{"$f":"AB258*7808/AF258","v":0.28090877954851473},{"$f":"-LOG10(AD258)","v":0.5514346871071139},2736]
["High","O15069","NAC-alpha domain-containing protein 1 [OS=Homo sapiens]",1,1,2,1,1562,161,4.23,4.2,"transport","translational apparatus;nucleus;other cell component","other molecular function","NACAD","ENSG00000136274","","","",38.2,33.3,27.9,34.2,30.8,30.1,1.0452155625657202,0.06380051070172266,0.6804233392660979,0.1672207980273756,0.8292095259855926,0.08133571736060079,6407]
["High","O15075-1","serine/threonine-protein kinase DCLK1 [OS=Homo sapiens]",11,4,8,4,740,82.2,8.66,21.01,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","DCLK1; LOC111158544","ENSCANG00000018654; ENSCCAG00000004898; ENSCJAG00000018203; ENSG00000133083; ENSMFAG00000030114; ENSMLEG00000042752; ENSMMUG00000016791; ENSMNEG00000028724; ENSNLEG00000001363; ENSPPAG00000038110; ENSPTRG00000005778; ENSRBIG00000027120; ENSRROG00000019788; ENSSBOG00000035278","Orexin receptor pathway","","",222.4,240.1,243.1,267.3,275.7,291.5,0.8455362492510485,-0.24206148869244054,0.011000443752203274,1.9585897952739506,0.08504105427445857,1.070371364397958,1010]
["High","O15078-1","Centrosomal protein of 290 kDa [OS=Homo sapiens]",3,6,7,6,2479,290.2,5.95,16.08,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CEP290","ENSG00000198707","Clear cell renal cell carcinoma pathways; Ciliary landscape; Joubert syndrome; Ciliopathies","Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",560.7,618,571.7,696.3,621.4,604,0.9108601758859345,-0.13469848876149998,0.1617090311038556,0.7912657249974587,0.37136003378203075,0.43020483738107845,3400]
["High","O15083","ERC protein 2 [OS=Homo sapiens]",6,7,14,1,957,110.5,6.99,27.61,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","ERC2","ENSG00000187672","Exercise-induced circadian regulation","","",61.9,63.8,86.7,66.6,48.7,79.4,1.090909090909091,0.12553088208385912,0.6473424611471723,0.18886590536101244,0.8087119898619394,0.0922061180464523,6250]
["High","O15084","serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A [OS=Homo sapiens]",12,9,11,9,1053,112.9,6.25,28.1,"","cytosol;nucleus","","ANKRD28","ENSG00000206560","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",352.3,318.7,342,318.3,346.7,327.2,1.020963515420278,0.029931311795822174,0.6221676222581187,0.20609259342099961,0.7915732107856267,0.10150891204629606,6137]
["High","O15085-2","Isoform 2 of Rho guanine nucleotide exchange factor 11 [OS=Homo sapiens]",15,16,21,16,1562,172.1,5.54,39.81,"","","","ARHGEF11","","","","",546,550.8,507.3,554.2,551.1,549.1,0.969596228239845,-0.04454400819516058,0.29267839103885784,0.5336093411091458,0.5253408913175637,0.2795587934051478,4350]
["High","O15091","Mitochondrial ribonuclease P protein 3 [OS=Homo sapiens]",16,8,10,8,583,67.3,8.78,22.84,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","other molecular function","PRORP","ENSG00000100890","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",301.4,332.8,329.1,445.8,391.2,415,0.7694089456869011,-0.37817749137305445,0.006702713894329786,2.1737493180918284,0.06517408479069361,1.1859250587118741,803]
["High","O15111","Inhibitor of nuclear factor kappa-B kinase subunit alpha [OS=Homo sapiens]",4,2,2,2,745,84.6,6.73,8.32,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CHUK","ENSG00000213341","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Constitutive Signaling by AKT1 E17K in Cancer; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; AKT phosphorylates targets in the cytosol","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",69.9,64.1,54.9,64.6,58,53.9,1.070254957507082,0.09795451822982704,0.484043629647286,0.3151154911219377,0.6943620540668765,0.1584140207803761,5443]
["High","O15116","U6 snRNA-associated Sm-like protein LSm1 [OS=Homo sapiens]",29,4,6,4,133,15.2,5.22,5.98,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM1","ENSG00000175324","","mRNA decay by 5' to 3' exoribonuclease","RNA degradation",359.5,320.5,320.1,369.8,338.9,323.4,0.9689952523980235,-0.04543849772854028,0.6024196105549192,0.2201008989966585,0.7801778602111145,0.10780637820337573,6029]
["High","O15118","Niemann-Pick C1 protein [OS=Homo sapiens]",5,7,10,7,1278,142.1,5.36,21.92,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","NPC1","ENSG00000141458","Irinotecan pathway; Irinotecan pathway; Irinotecan pathway; Ebola virus infection in host; Irinotecan pathway; Irinotecan pathway","LDL clearance","Lysosome; Cholesterol metabolism",542.3,540.4,538,456,446.7,449.4,1.1986539457140741,0.2614152093253603,7.8051227111469424E-6,5.10762026462526,6.094239812863533E-3,2.2150804599666243,10]
["High","O15120","1-acyl-sn-glycerol-3-phosphate acyltransferase beta [OS=Homo sapiens]",6,1,2,1,278,30.9,9.01,4.84,"other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","AGPAT2","ENSG00000169692","Adipogenesis; Triacylglyceride synthesis; Ciliary landscape; Congenital generalized lipodystrophy (CGL)","Neutrophil degranulation; Synthesis of PA","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fat digestion and absorption",14.8,14.4,14.7,18.7,16.6,18.2,0.8205607476635516,-0.2853179517531508,0.00768397547393036,2.1144140300094207,0.06944037094959288,1.1583879678296787,864]
["High","O15121","Sphingolipid delta(4)-desaturase DES1 [OS=Homo sapiens]",6,3,5,3,323,37.8,7.46,14.01,"cell organization and biogenesis;other metabolic processes;developmental processes","plasma membrane;other membranes;mitochondrion;ER/Golgi","other molecular function","DEGS1","ENSG00000143753","Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence","Neutrophil degranulation; Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",96.8,137.9,107.3,118.4,103.4,121.9,0.9950538260110561,-0.007153526599037081,0.9686956451373967,0.013812652670576872,0.9817725333895111,0.00798912212841957,7704]
["High","O15126-1","Secretory carrier-associated membrane protein 1 [OS=Homo sapiens]",6,2,5,2,338,37.9,7.42,13.7,"transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP1","ENSG00000085365","","Neutrophil degranulation","",284.9,290.6,268.8,318.7,286.6,308.3,0.9241462346760071,-0.11380693659110866,0.1147429633824735,0.9402739381032473,0.30681954044190174,0.5131169848930303,2920]
["High","O15127","Secretory carrier-associated membrane protein 2 [OS=Homo sapiens]",17,4,13,4,329,36.6,6.1,33.7,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP2","ENSG00000140497","Serotonin transporter activity; Monoamine transport","","",676.4,767.9,602.4,602.3,551.6,594.7,1.1704792405352853,0.22709934722875125,0.11995926113801654,0.9209662178430749,0.31473182492124774,0.5020593400582806,2976]
["High","O15143","Actin-related protein 2/3 complex subunit 1B [OS=Homo sapiens]",30,9,23,9,372,40.9,8.35,62.02,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ARPC1B","ENSG00000130429","Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",1535.8,1853,1689.8,1462.1,1745.6,1690.8,1.036766357048076,0.052090808802579554,0.6590860361091434,0.18105788955082613,0.8154244604563764,0.08861626506696639,6311]
["High","O15144","Actin-related protein 2/3 complex subunit 2 [OS=Homo sapiens]",59,17,56,17,300,34.3,7.36,116.07,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","ARPC2","ENSG00000163466","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",3068.3,3280.6,3202,2739,3446.9,3096,1.0289811353278961,0.04121653304007324,0.6961346306875198,0.15730676080552108,0.8399658779799343,0.07573835596909316,6471]
["High","O15145","Actin-related protein 2/3 complex subunit 3 [OS=Homo sapiens]",21,4,14,4,178,20.5,8.59,26.18,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC3","ENSG00000111229","Pathogenic Escherichia coli infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",464.7,489.9,479.7,472.6,494.8,488.7,0.9850285007897808,-0.02176262681254177,0.5024109567710946,0.29894089790673156,0.7071975392948813,0.1504592591269317,5547]
["High","O15151","Protein Mdm4 [OS=Homo sapiens]",5,2,2,2,490,54.8,5,2.63,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","nucleus","other molecular function","MDM4","ENSG00000198625","Glioblastoma signaling pathways; Malignant pleural mesothelioma","Regulation of TP53 Activity through Methylation; Ub-specific processing proteases; Regulation of TP53 Degradation; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Oncogene Induced Senescence; Stabilization of p53","p53 signaling pathway; MicroRNAs in cancer",41.7,46.6,35.4,55.8,52,55.4,0.75796568627451,-0.3997955569951255,0.018987990624067894,1.7215209914005167,0.11378221856693946,0.943925602454466,1303]
["High","O15155","BET1 homolog [OS=Homo sapiens]",25,2,3,2,118,13.3,9.06,9.82,"cell organization and biogenesis;transport","other membranes;ER/Golgi","other molecular function","BET1","ENSG00000105829","","COPI-mediated anterograde transport; COPII-mediated vesicle transport","SNARE interactions in vesicular transport",153.6,191.6,161.5,161,174.2,184,0.9759244992295839,-0.03515855447659667,0.7706765854096063,0.1131278354889835,0.8834888825250633,0.053798911112956815,6811]
["Medium","O15156","Zinc finger and BTB domain-containing protein 7B [OS=Homo sapiens]",1,1,1,1,539,58,5.86,2.12,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB7B","ENSG00000160685","Ectoderm differentiation; Ectoderm differentiation","","",56.8,50.9,61.8,91.2,72.1,89.8,0.6696957724219675,-0.578422234086978,0.015673191469682015,1.8048425608673504,0.10283720923972872,0.9878497176012458,1190]
["High","O15160","DNA-directed RNA polymerases I and III subunit RPAC1 [OS=Homo sapiens]",34,9,31,9,346,39.2,5.5,53.07,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR1C","ENSG00000171453","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase; Cytosolic DNA-sensing pathway",845.6,809.4,866.6,833.5,853.4,833.6,1.0004364213449712,6.2948555964979986E-4,0.9846964168066044,0.006697642423727124,0.9911705069519101,0.003851629209277043,7757]
["High","O15162","phospholipid scramblase 1 [OS=Homo sapiens]",9,2,2,2,318,35,4.94,2.44,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;transporter activity;nucleic acid binding activity;other molecular function","PLSCR1","ENSG00000188313","EGF/EGFR signaling pathway; Complement system in neuronal development and plasticity","","",65.9,68.5,59.1,71.9,64,65.9,0.9588701684836471,-0.06059260807458464,0.4936635413628175,0.3065689456377093,0.7018435781064966,0.1537596695437914,5492]
["High","O15164","Transcription intermediary factor 1-alpha [OS=Homo sapiens]",29,19,35,18,1050,116.8,7.11,75.15,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function","TRIM24","ENSG00000122779","","Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",789.1,821.5,800.1,956.8,880.8,847.9,0.8976726866505306,-0.15573859582949762,0.052740706451938485,1.2778540572099377,0.1941534351611201,0.7118549210678642,2121]
["Medium","O15169","Axin-1 [OS=Homo sapiens]",1,1,1,1,862,95.6,6.96,1.89,"cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","AXIN1","ENSG00000103126","Alzheimer's disease and miRNA effects; Neural crest differentiation; Mesodermal commitment pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Wnt signaling pathway; TGF-beta signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)","Ub-specific processing proteases; Degradation of AXIN; Estrogen-dependent gene expression; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling","Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Colorectal cancer; Endometrial cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",45.8,47.2,49.9,54.6,42.4,49.6,0.9747612551159618,-0.03687918703799543,0.7581048022237491,0.12027075230822716,0.8770606453938411,0.05697037579098071,6749]
["High","O15173","Membrane-associated progesterone receptor component 2 [OS=Homo sapiens]",52,12,38,10,223,23.8,4.88,90.01,"transport;developmental processes;signal transduction","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","PGRMC2","ENSG00000164040","Ciliary landscape","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","",649.6,667.6,653.2,687.5,654,686.9,0.971406034312759,-0.041853646567674055,0.19278696636499426,0.7149223305322476,0.41038185206594197,0.38681185287159575,3668]
["High","O15182","Centrin-3 [OS=Homo sapiens]",34,5,6,5,167,19.5,4.74,10.29,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","CETN3","ENSG00000153140","Breast cancer pathway","","",319.9,303.8,316.8,402.5,312.1,315.7,0.9128409201203533,-0.1315646298038293,0.3742879342130096,0.42679417285664556,0.6050600808147368,0.2182014989495223,4830]
["High","O15194-1","CTD small phosphatase-like protein [OS=Homo sapiens]",11,3,4,2,276,31.1,5.54,2.79,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","CTDSPL","ENSG00000144677; ENSPTRG00000014749","","","",102.4,124.5,111.6,137.4,143.6,135.2,0.8133109082172033,-0.2981211312729755,0.0197456443658737,1.7045286892266471,0.11626997828713563,0.934532408636766,1326]
["High","O15213","WD repeat-containing protein 46 [OS=Homo sapiens]",26,15,25,15,610,68,9.67,52.8,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","WDR46","ENSG00000204221; ENSG00000206284; ENSG00000226916; ENSG00000227057; ENSG00000236222","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",640,619.9,620.1,645.1,621.8,692.8,0.9593305097719038,-0.059900154866781415,0.29246423209245886,0.5339272398543319,0.5253187771285758,0.2795770753865335,4347]
["High","O15226","NF-kappa-B-repressing factor [OS=Homo sapiens]",36,22,44,22,690,77.6,8.79,73.45,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","NKRF","ENSG00000186416","Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway","","",2352.2,2459,2281.8,2342.8,2220.8,2300.2,1.033392581368921,0.04738843193648609,0.2899901478492345,0.5376167566093011,0.5224372575927141,0.28196585893446485,4334]
["High","O15228","Dihydroxyacetone phosphate acyltransferase [OS=Homo sapiens]",26,16,30,16,680,77.1,6.57,55.14,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","other molecular function","GNPAT","ENSG00000116906","Triacylglyceride synthesis","Peroxisomal protein import; Plasmalogen biosynthesis; Synthesis of PA","Glycerophospholipid metabolism; Peroxisome",1185.6,1069.1,1165.8,1077.8,1096.5,1070,1.054310637117406,0.07629999847534467,0.18608878402243276,0.7302798019576676,0.40082240707507727,0.39704800820604463,3625]
["High","O15230","Laminin subunit alpha-5 [OS=Homo sapiens]",11,31,40,31,3695,399.5,7.02,79.53,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;extracellular structural activity","LAMA5","ENSG00000130702","Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Malignant pleural mesothelioma","Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer",1615.3,1600.2,1526.1,1653.2,1575.2,1604.1,0.9811898603207452,-0.027395769818348244,0.44442614871390185,0.3522003963826864,0.6622288872439209,0.17899187870777764,5240]
["High","O15231-1","zinc finger protein 185 [OS=Homo sapiens]",4,3,4,2,689,73.5,7.01,8.4,"","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ZNF185","ENSG00000147394","","","",202.9,221.5,189.4,192.8,174.3,170.4,1.141953488372093,0.1915038911022998,0.09322790837602474,1.0304540593267337,0.27161324947761234,0.5660490486968872,2680]
["High","O15231-2","Isoform 2 of Zinc finger protein 185 [OS=Homo sapiens]",4,2,3,1,452,48.6,5.43,4.51,"","","","ZNF185","","","","",120.1,115.4,102.6,103.1,96.4,78.2,1.2175009002520707,0.2839228390745314,0.09120551936327913,1.039978879253981,0.2682232373591275,0.5715036000128335,2655]
["High","O15234","Protein CASC3 [OS=Homo sapiens]",10,6,6,6,703,76.2,6.48,15.76,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CASC3","ENSG00000108349","","Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Nucleocytoplasmic transport; mRNA surveillance pathway",379.9,428.2,433.9,497.8,446.1,499.7,0.8603491271820448,-0.217005874789389,0.051931178631315446,1.2845718205347778,0.1924435893466118,0.7156965514842426,2107]
["High","O15235","28S ribosomal protein S12, mitochondrial [OS=Homo sapiens]",24,2,3,2,138,15.2,10.29,10.61,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS12","ENSG00000128626; ENSG00000283018","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",90.5,50.4,55.2,56.7,64.5,60.5,1.0792515134837646,0.11003111595803336,0.7275368730651377,0.138144990846649,0.8596561599413733,0.06567522050033942,6608]
["High","O15240","Neurosecretory protein VGF [OS=Homo sapiens]",29,17,38,17,615,67.2,4.78,79.58,"cell-cell signaling;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;ER/Golgi;other cell component","signal transduction activity or receptor binding","VGF","ENSG00000128564","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; NGF-stimulated transcription","",649.2,812.7,662.2,375.9,351.2,302,2.0640365367797107,1.045468509019092,0.003012458002002284,2.521078999064644,0.04480242300882635,1.3486984978119654,525]
["High","O15243","Leptin receptor gene-related protein [OS=Homo sapiens]",18,3,4,3,131,14.2,6.51,5.11,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding","LEPROT","ENSG00000213625","","","",273.9,251.3,251.8,345.3,314.5,301,0.8087010824313072,-0.3063215524105617,0.015310447492997113,1.815012115578736,0.10113703386237011,0.9950897874653372,1182]
["High","O15254","Peroxisomal acyl-coenzyme A oxidase 3 [OS=Homo sapiens]",13,5,7,5,700,77.6,7.25,11.54,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOX3","ENSG00000087008","PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","Fatty acid degradation; beta-Alanine metabolism; alpha-Linolenic acid metabolism; Propanoate metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; PPAR signaling pathway; cAMP signaling pathway; Peroxisome; Alcoholic liver disease",52.1,57.6,52.5,49.8,44.2,51.7,1.1132463967055595,0.15477294215276055,0.12720952660458104,0.8954803635549342,0.3246982620884501,0.4885200358809775,3059]
["High","O15258","Protein RER1 [OS=Homo sapiens]",14,2,5,2,196,22.9,9.54,7.25,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","RER1","ENSG00000157916","","","",223.4,264.8,178.9,200.9,184.4,208.1,1.1241995281429054,0.16889811448727912,0.39451107601744523,0.403940799334833,0.62342491024979,0.20521584856561442,4941]
["High","O15260-1","surfeit locus protein 4 [OS=Homo sapiens]",17,4,16,4,269,30.4,7.78,29.12,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","SURF4","ENSG00000148248; ENSG00000280951; ENSGGOG00000014456; ENSNLEG00000013096; ENSPTRG00000021519","","COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation","",434.6,418.7,486.2,398.8,443.6,425.3,1.0566380058373432,0.07948120772196941,0.37813357997540037,0.42235475360690405,0.6078787301725193,0.21618305242130484,4857]
["Medium","O15265","Ataxin-7 [OS=Homo sapiens]",2,1,1,1,892,95.4,9.85,2.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","","ATXN7","ENSG00000163635","","Ub-specific processing proteases; HATs acetylate histones","",15.7,15,16.9,18.6,16.3,22.1,0.8350877192982454,-0.26000034574416087,0.1523037577108447,0.8172893814114813,0.3600326188938164,0.4436581504442601,3303]
["High","O15269","serine palmitoyltransferase 1 [OS=Homo sapiens]",31,14,50,14,473,52.7,6.01,111.29,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC1","ENSG00000090054","Sphingolipid pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",1733.7,1774,1819.9,1506.4,1535.7,1534.4,1.164121053206599,0.2192410872670341,7.1767715662805493E-4,3.1440708769643804,0.02364397991118925,1.6262794183158487,237]
["High","O15270","Serine palmitoyltransferase 2 [OS=Homo sapiens]",18,8,17,8,562,62.9,7.78,38.64,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC2","ENSG00000100596","Sphingolipid pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",580.5,537.9,558.7,434.3,453.8,448.8,1.2544692946368465,0.3270771586567805,1.1363742533149702E-3,2.9444786145917496,0.029576033899610957,1.529060064652777,300]
["High","O15287","Fanconi anemia group G protein [OS=Homo sapiens]",12,5,6,5,622,68.5,5.47,11.98,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus","nucleic acid binding activity","FANCG","ENSG00000221829","Retinoblastoma gene in cancer; DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",48.3,51.6,52.5,53.1,70.4,47.8,0.8896672504378285,-0.16866224859067677,0.4154701362735442,0.38146018756632694,0.6402192271608117,0.19367128719836266,5067]
["High","O15294","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit [OS=Homo sapiens]",11,12,27,12,1046,116.9,6.7,58.4,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","OGT","ENSG00000147162","Ectoderm differentiation; Ectoderm differentiation; Malignant pleural mesothelioma","UCH proteinases; Regulation of necroptotic cell death; HATs acetylate histones","Other types of O-glycan biosynthesis; Insulin resistance",998,1011,1042.1,1320.7,1282.9,1316.9,0.7782425711006248,-0.36170819471547944,8.2633033977645208E-5,4.082846301272845,0.011124116022369894,1.953734490177147,58]
["High","O15305","Phosphomannomutase 2 [OS=Homo sapiens]",38,10,42,10,246,28.1,6.77,55.91,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PMM2","ENSG00000140650","Nephrotic syndrome","Defective PMM2 causes PMM2-CDG (CDG-1a); Synthesis of GDP-mannose","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",2227.1,2170.1,2070.8,2329.4,2112,2210.9,0.9722952963636639,-0.040533552765034904,0.47329950035086177,0.3248639540043875,0.6857529223862551,0.16383233294177751,5389]
["High","O15318","DNA-directed RNA polymerase III subunit RPC7 [OS=Homo sapiens]",14,3,3,3,223,25.9,4.63,5.5,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","POLR3G","ENSG00000113356","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",67.7,60.5,55.8,114,91.9,87.7,0.6267029972752043,-0.6741462018988378,0.014576969902437991,1.836332742918888,0.09888530060663409,1.0048682618900444,1151]
["High","O15320","Endoplasmic reticulum export factor CTAGE5 [OS=Homo sapiens]",25,18,32,18,804,90.9,5.22,81.02,"","","","","","","","",1715.8,1623.5,1699.7,1908,1805.5,1803.5,0.9133587094435381,-0.13074652416334118,0.02354299886649428,1.6281382182887294,0.12378702703675916,0.9073248672833251,1485]
["High","O15321-1","Transmembrane 9 superfamily member 1 [OS=Homo sapiens]",5,3,3,3,606,68.8,7.17,4.2,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","TM9SF1","ENSCANG00000029500; ENSCCAG00000032112; ENSG00000100926; ENSG00000285465; ENSPPAG00000042444; ENSPTRG00000032568; ENSRBIG00000029944; ENSRROG00000042511","","","",121.8,126,132.7,130.8,131.9,136.4,0.9533951390628915,-0.06885382512036374,0.16074125736897646,0.7938726388060048,0.37066383270436154,0.4310197879202858,3386]
["High","O15344-1","E3 ubiquitin-protein ligase Midline-1 [OS=Homo sapiens]",26,16,36,16,667,75.2,6.8,95.44,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","MID1","ENSCANG00000031338; ENSCCAG00000029160; ENSCJAG00000000987; ENSCSAG00000015273; ENSG00000101871; ENSMFAG00000037182; ENSMLEG00000034816; ENSMMUG00000020179; ENSMNEG00000026727; ENSPANG00000006683; ENSPPAG00000038224; ENSRBIG00000037000; ENSTSYG00000003295","","Interferon gamma signaling","Ubiquitin mediated proteolysis",1436.3,1539,1480.1,1609.7,1718.6,1674.8,0.8905278727189142,-0.16726732780072645,0.013654875959489821,1.8647122406252203,0.09587884126951127,1.0182772232126236,1112]
["High","O15347","High mobility group protein B3 [OS=Homo sapiens]",13,2,5,2,200,23,8.37,4.96,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","HMGB3","ENSG00000029993","","","",122.2,123,141.6,213.3,158.7,108.8,0.8044925124792011,-0.31384910123434473,0.36701884009553876,0.43531164163477387,0.5986386261679479,0.22283526445808702,4787]
["High","O15355","Protein phosphatase 1G [OS=Homo sapiens]",56,25,161,25,546,59.2,4.36,383.7,"protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","PPM1G","ENSG00000115241","VEGFA-VEGFR2 signaling pathway; mRNA processing","","",6137.6,5817.6,5544.5,5994.7,5335.9,5694.1,1.0279006384840852,0.03970081385631211,0.5700126277309321,0.24411552311151574,0.7587212064989972,0.11991777709741369,5866]
["High","O15357","Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [OS=Homo sapiens]",18,18,39,18,1258,138.5,6.54,88.27,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","INPPL1","ENSG00000165458","EGF/EGFR signaling pathway; Insulin signaling","Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; B cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway",1482.8,1415.3,1475.9,1608.1,1491.6,1618.7,0.9270091556459817,-0.1093445071262811,0.06714160654547022,1.1730082712875114,0.2218542801130053,0.653932188261245,2363]
["High","O15360","Fanconi anemia group A protein [OS=Homo sapiens]",6,5,6,5,1455,162.7,6.6,5.61,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","","FANCA","ENSG00000187741","DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",28.9,27.3,25.1,27.2,24.6,31,0.9818840579710147,-0.026375415424297124,0.8283192745488092,0.08180223272196796,0.9168580799088605,0.037697883394803386,7054]
["High","O15371","Eukaryotic translation initiation factor 3 subunit D [OS=Homo sapiens]",51,21,82,21,548,63.9,6.05,173.31,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3D","ENSG00000100353","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",2610.6,2535,2619.5,2622.5,2659.1,2722.2,0.9701766660836103,-0.04368061348932878,0.11475229950708808,0.9402386029302798,0.30673945722401363,0.5132303552451942,2921]
["High","O15372","Eukaryotic translation initiation factor 3 subunit H [OS=Homo sapiens]",55,16,78,16,352,39.9,6.54,148.32,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3H","ENSG00000147677","Translation factors; VEGFA-VEGFR2 signaling pathway; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Measles",3980.6,3641.8,4034.6,4251.1,4263.7,4201.6,0.9166902582491899,-0.1254937529698797,0.04690605997084996,1.328771045517615,0.18312125812619826,0.7372612365229607,2000]
["High","O15379","Histone deacetylase 3 [OS=Homo sapiens]",9,4,8,4,428,48.8,5.16,16.06,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","HDAC3","ENSG00000171720","Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome","Cytoprotection by HMOX1; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling","Neutrophil extracellular trap formation; Thyroid hormone signaling pathway; Alcoholism; Viral carcinogenesis",394,359.8,378.6,360.3,390.1,389.1,0.9937691970162353,-0.009017270246912184,0.8730845152579598,0.05894371421699759,0.9351226193599658,0.0291314378763368,7290]
["High","O15381-1","Nuclear valosin-containing protein-like [OS=Homo sapiens]",39,28,85,28,856,95,6.48,180.61,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","NVL","ENSG00000143748","","","Ribosome biogenesis in eukaryotes",2635.8,2567.7,2651.9,3063.6,2987.6,3018.3,0.866133744969403,-0.20733827743444194,2.8398080694644508E-4,3.5467110110759266,0.016303839269395905,1.7877101147875085,136]
["High","O15397-1","Importin-8 [OS=Homo sapiens]",19,15,32,14,1037,119.9,5.16,74.12,"transport;signal transduction","cytosol;nucleus","other molecular function","IPO8","ENSG00000133704","","Transcriptional regulation by small RNAs","Nucleocytoplasmic transport",725.8,736.1,815.6,853.8,936.5,945.8,0.8323891670626073,-0.2646699053147776,0.019913279592375027,1.7008572085020957,0.11629236129937487,0.9344488111054445,1337]
["High","O15400","Syntaxin-7 [OS=Homo sapiens]",39,7,19,7,261,29.8,5.55,35.83,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STX7","ENSG00000079950","","","SNARE interactions in vesicular transport; Phagosome",377.1,416.6,355.7,327.9,356.8,332.5,1.1299646087298467,0.17627758714530276,0.09189784800004505,1.0366946585012482,0.2693462451893212,0.5696890743408762,2664]
["Low","O15417-1","Trinucleotide repeat-containing gene 18 protein [OS=Homo sapiens]",0,1,2,1,2968,314.3,8.7,2.13,"","other membranes;cytosol;mitochondrion;nucleus","other molecular function","TNRC18","ENSG00000182095","","","",103.8,113.5,136.2,124.7,151.4,140.9,0.8477218225419664,-0.23833716863526486,0.16166008336526796,0.7913972015793673,0.37157548746423674,0.42995294379075993,3397]
["Medium","O15427","Monocarboxylate transporter 4 [OS=Homo sapiens]",2,1,1,1,465,49.4,7.96,2.4,"transport","plasma membrane;other membranes;nucleus;other cell component","transporter activity","SLC16A3","ENSG00000141526","Metabolic reprogramming in colon cancer","Pyruvate metabolism; Basigin interactions; Proton-coupled monocarboxylate transport","Central carbon metabolism in cancer",125.5,133.1,125,67.5,49.2,51.2,2.2846932698034546,1.1920004900811008,3.490338084254093E-4,3.457132503982183,0.017358318319653475,1.7604923517327817,157]
["Medium","O15431","High affinity copper uptake protein 1 [OS=Homo sapiens]",6,1,2,1,190,21.1,7.42,5.3,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","SLC31A1","ENSG00000136868","Copper homeostasis","Metal ion SLC transporters","Platinum drug resistance; Mineral absorption",83.6,86.6,91,78.9,85.4,87.7,1.0365079365079364,0.05173116315915177,0.4180994094349888,0.37872044588968745,0.6424956089093471,0.19212983614134768,5081]
["High","O15439-1","multidrug resistance-associated protein 4 [OS=Homo sapiens]",10,9,10,9,1325,149.4,8.19,16.16,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","ABCC4","ENSG00000125257","Fluoropyrimidine activity; Drug induction of bile acid pathway; Ectoderm differentiation; Pregnane X receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; TYROBP causal network in microglia; Aspirin and miRNAs; Proximal tubule transport; FOXA2 pathway; Prostaglandin synthesis and regulation","ABC-family proteins mediated transport; Platelet degranulation","Antifolate resistance; ABC transporters; cAMP signaling pathway; Bile secretion",221.2,228.9,221.5,245.1,251.4,260.2,{"$f":"AVERAGE(T322:V322)/AVERAGE(W322:Y322)","v":0.8875379939209727},{"$f":"LOG(Z322,2)","v":-0.17211921485522422},{"$f":"TTEST(T322:V322,W322:Y322,2,2)","v":0.004941699423680493},{"$f":"-LOG10(AB322)","v":2.3061236738685498},{"$f":"AB322*7808/AF322","v":0.05567790634934674},{"$f":"-LOG10(AD322)","v":1.2543171038217211},693]
["High","O15440","Multidrug resistance-associated protein 5 [OS=Homo sapiens]",9,8,12,8,1437,160.6,8.66,25.56,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","ABCC5","ENSG00000114770","Fluoropyrimidine activity; Nuclear receptors meta-pathway; NRF2 pathway","ABC-family proteins mediated transport; Hyaluronan biosynthesis and export","Antifolate resistance; ABC transporters",188.8,222.1,200.1,175.9,168,162.2,1.207271290258842,0.2717499056973699,0.02955331277418687,1.5293938298788474,0.141046617445508,0.8506373245555161,1636]
["High","O15446-1","DNA-directed RNA polymerase I subunit RPA34 [OS=Homo sapiens]",10,3,3,3,510,55,8.51,5.83,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytosol;mitochondrion;nucleus;other cell component","other molecular function","POLR1G","ENSG00000117877","","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase",71.9,77,75,198,68.1,54.9,0.6975077881619939,-0.5197187691570677,0.5177406402515279,0.2858877435670175,0.7194374299846823,0.14300697100328189,5619]
["High","O15460-1","Prolyl 4-hydroxylase subunit alpha-2 [OS=Homo sapiens]",13,6,8,6,535,60.9,5.71,16.6,"protein metabolism;other metabolic processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","P4HA2","ENSG00000072682","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","Arginine and proline metabolism; Metabolic pathways",497,511.8,546.3,580.7,593.9,579.3,0.8866526027709676,-0.1735591385362292,0.012416042360516546,1.9060168143762215,0.09119892638844138,1.040010274240883,1063]
["High","O15484","calpain-5 [OS=Homo sapiens]",28,13,18,13,640,73.1,7.64,34.33,"protein metabolism;signal transduction","other cell component","other molecular function","CAPN5","ENSG00000149260","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",925.2,991.9,993.3,695.3,734.1,730.9,1.3472202934777575,0.4299857753156528,6.232790931750069E-4,3.2053174405249893,0.022323684217937862,1.651234129470959,218]
["High","O15488-1","Glycogenin-2 [OS=Homo sapiens]",10,4,10,4,501,55.1,5.1,27.53,"other metabolic processes","cytosol;other cell component","other molecular function","GYG2","ENSG00000056998","Glycogen synthesis and degradation","Glycogen synthesis; Glycogen storage disease type 0 (liver GYS2); Glycogen storage disease type IV (GBE1); Glycogen breakdown (glycogenolysis)","Starch and sucrose metabolism; Metabolic pathways",811.1,751.2,804.5,776,774.1,814.3,1.001015056673998,0.001463674499123403,0.9739701147468658,0.011454368788374157,0.9853276309851682,6.4193383651166055E-3,7718]
["High","O15498","Synaptobrevin homolog YKT6 [OS=Homo sapiens]",34,7,37,7,198,22.4,6.92,81.66,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","YKT6","ENSG00000106636","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport","SNARE interactions in vesicular transport",1944.5,2027.9,1958,1650.7,1675.7,1691.6,1.1818254284575527,0.2410169457534055,4.3411531094301445E-4,3.3623948966289303,0.018421588846973137,1.7346729149798314,184]
["High","O15504","nucleoporin-like protein 2 [OS=Homo sapiens]",17,7,10,7,423,44.8,9.19,20.54,"transport","other membranes;cytosol;nucleus","other molecular function","NUP42","ENSG00000136243","","HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus","Nucleocytoplasmic transport",346.5,367.5,322.5,377.7,322.1,364.1,0.9742456997838141,-0.037642436380406964,0.6886652813457669,0.1619918111631094,0.8345644135880409,0.0785401378508203,6443]
["High","O15511-1","Actin-related protein 2/3 complex subunit 5 [OS=Homo sapiens]",40,4,5,4,151,16.3,5.67,16.5,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","Arpc5; ARPC5","ENSDLEG00000020693; ENSG00000162704; ENSGGOG00000007894; ENSPCTG00005002795; ENSPPAG00000038421; ENSPPYG00000000425; ENSPTRG00000001767; ENSRNOG00000028062; ENSSBOG00000027275; ENSSSCG00000015560; ENSSSCG00070012419; ENSSTOG00000001001","Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton","Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Neutrophil degranulation; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",69.3,94.8,71.3,111.9,95,93.3,0.7841439040639573,-0.3508096565822444,0.09955256760940696,1.001947534388787,0.28275971185676596,0.5485824695736199,2749]
["High","O15514","DNA-directed RNA polymerase II subunit RPB4 [OS=Homo sapiens]",11,1,3,1,142,16.3,4.79,2.94,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","POLR2D","ENSG00000144231","Pyrimidine metabolism","Estrogen-dependent gene expression; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; mRNA Splicing - Major Pathway; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere","RNA polymerase; Huntington disease",23.2,22.7,18.4,38.3,23.7,18.6,0.7977667493796528,-0.3259611012000198,0.4231835890693695,0.3734711824539879,0.6466178989146061,0.1893522779300652,5110]
["High","O15523","atp-dependent rna helicase ddx3y [OS=Homo sapiens]",60,37,183,9,660,73.1,7.55,381.16,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX3Y","ENSG00000067048","Novel intracellular components of RIG-I-like receptor (RLR) pathway","","",820,793.7,873.3,756,809,772,1.0641848523748396,0.08974877343408132,0.15077575996164755,0.8216684738580494,0.35837355670640614,0.4456640430952136,3285]
["Medium","O15525","transcription factor MafG [OS=Homo sapiens]",6,1,2,1,162,17.8,10.04,2.33,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","MAFG","ENSG00000197063","Quercetin and Nf-kB / AP-1 induced apoptosis; Nuclear receptors meta-pathway; NRF2 pathway; Ethanol metabolism production of ROS by CYP2E1","Factors involved in megakaryocyte development and platelet production","",127.1,108.6,110.6,146.3,129.3,129.7,0.8544288181593881,-0.22696778784961236,0.07231732410890364,1.1407576520326594,0.23294293178313516,0.6327504628682727,2424]
["Medium","O15527-1","N-glycosylase/DNA lyase [OS=Homo sapiens]",3,1,1,1,345,38.8,8.6,2.96,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","OGG1","ENSG00000114026","Base excision repair; DNA repair pathways, full network","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Defective OGG1 Substrate Binding; Defective OGG1 Substrate Processing","Base excision repair",132.2,154.7,133.5,131.1,147.9,144.9,0.9917433356923804,-0.011961297092916996,0.9024856331753786,0.044559702976120094,0.9507026205927356,0.021955308964344628,7412]
["High","O15530-1","3-phosphoinositide-dependent protein kinase 1 [OS=Homo sapiens]",10,5,8,5,556,63.1,7.36,12.47,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function","PDPK1","ENSG00000140992","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; Serotonin HTR1 group and FOS pathway","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of TP53 Degradation; PIP3 activates AKT signaling; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ","Platinum drug resistance; PPAR signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Thyroid hormone signaling pathway; Insulin resistance; Aldosterone-regulated sodium reabsorption; Toxoplasmosis; Proteoglycans in cancer; Chemical carcinogenesis; Endometrial cancer; Prostate cancer; Non-small cell lung cancer; Choline metabolism in cancer; Lipid and atherosclerosis",346.2,372.1,365.2,304.7,285.9,297.7,1.2197455814477094,0.2865802570823262,2.3690862874384635E-3,2.6254191210096423,0.04003858383618945,1.397521291907132,462]
["High","O15540","Fatty acid-binding protein, brain [OS=Homo sapiens]",22,2,4,2,132,14.9,5.59,9.22,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus","other molecular function","FABP7","ENSG00000164434","PPAR signaling pathway; Fatty acid transporters","Triglyceride catabolism; NOTCH3 Intracellular Domain Regulates Transcription","PPAR signaling pathway",151,156.3,176.9,155.7,150.9,137.6,1.090049527239982,0.12439368645195575,0.23624583432538288,0.626635840577216,0.4656923692028754,0.3319008783228735,3961]
["High","O15541","RING finger protein 113A [OS=Homo sapiens]",22,5,10,5,343,38.8,5.69,21.61,"protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","RNF113A","ENSG00000125352","","","",387.2,421.8,385.4,456,382.5,435.2,0.9377404412341998,-0.0927394428969674,0.3478355717870832,0.45862600645958834,0.5803205436994755,0.23633205487507697,4680]
["High","O15550","Lysine-specific demethylase 6A [OS=Homo sapiens]",8,9,11,9,1401,154.1,7.44,21.8,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6A","ENSG00000147050","Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Malignant pleural mesothelioma","Activation of anterior HOX genes in hindbrain development during early embryogenesis; HDMs demethylate histones","Transcriptional misregulation in cancer",250.2,284.8,261,308.3,259.4,276.1,0.9433515050959941,-0.08413265678834016,0.41694238551459933,0.3799239531360631,0.6414751026794072,0.19282019506267822,5075]
["Medium","O15554","intermediate conductance calcium-activated potassium channel protein 4 [OS=Homo sapiens]",3,1,1,1,427,47.7,9.83,0,"cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","KCNN4","ENSG00000104783","","Ca2+ activated K+ channels","Insulin secretion; GnRH secretion; Salivary secretion; Protein digestion and absorption",238.8,136.2,245.6,159.3,259.8,202.1,0.9990341274951705,-1.3941328585823116E-3,0.9967268632620483,1.423836703183489E-3,0.9978770801833663,9.2295238583963465E-4,7799]
["High","O43143","Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [OS=Homo sapiens]",51,42,253,42,795,90.9,7.46,499.59,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","DHX15","ENSG00000109606","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",9695.4,9657.4,10192.9,10102.2,10994.8,10322.3,0.9403678630650586,-0.08870285894714934,0.12197193790950601,0.9137400759883736,0.31808847401383533,0.4974520673367717,2994]
["High","O43148-1","mRNA cap guanine-N7 methyltransferase [OS=Homo sapiens]",32,18,46,17,476,54.8,6.61,90.23,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNMT","ENSG00000101654","mRNA processing","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA surveillance pathway",2599,2514.8,2531.9,2722.4,2573.6,2665.3,0.9603582329519049,-0.05835543436720538,0.10507584958573736,0.9784970898411455,0.2910366206333584,0.5360523610541125,2819]
["High","O43149","Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",2,5,6,3,2961,330.9,5.95,4.67,"","","other molecular function","ZZEF1","ENSG00000074755","","","",218,203.6,224.4,222.7,222,204.4,0.9952241565244184,-0.006906591256641526,0.9099794910722976,0.04096839560692974,0.9542196973264169,0.020351622830667777,7446]
["High","O43149-3","Isoform 3 of Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",2,3,3,1,1085,119.9,5.67,5.48,"","","","ZZEF1","","","","",81.6,74.3,82.7,80.3,81.9,74,1.0101608806096527,0.014585078298070589,0.8337787692576722,0.0789491676309608,0.9197717759768161,0.0363199212738215,7078]
["High","O43150-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [OS=Homo sapiens]",7,6,8,6,1006,111.6,6.68,19.9,"other biological processes","plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","ASAP2","ENSG00000151693","Vitamin D receptor pathway","","Endocytosis; Fc gamma R-mediated phagocytosis",334.3,352.3,353.9,331.3,374.3,336.5,0.9984646387102966,-2.2167603184238198E-3,0.973226467090065,0.011786088854589392,0.9848305151683809,0.006638503167800901,7716]
["High","O43156","TELO2-interacting protein 1 homolog [OS=Homo sapiens]",10,9,12,9,1089,122,5.97,23.39,"other biological processes","nucleus;other cell component","","TTI1","ENSG00000101407","Fragile X syndrome; Malignant pleural mesothelioma","","mTOR signaling pathway",393.6,374.1,436.5,397.8,488.1,427.9,0.9165778657329883,-0.12567064812650097,0.321465325615712,0.492865864748727,0.5544513502115042,0.2561365545853439,4527]
["High","O43157","Plexin-B1 [OS=Homo sapiens]",8,11,15,11,2135,232.2,5.49,34.98,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PLXNB1","ENSG00000164050","","RHOD GTPase cycle; G alpha (12/13) signalling events; Sema4D induced cell migration and growth-cone collapse; Sema4D mediated inhibition of cell attachment and migration","Axon guidance",387.1,375.9,377.2,337.7,384.5,365.3,1.0484597701149425,0.06827150562224607,0.27890996870747903,0.5545359630473967,0.5094103007410518,0.29293227745295275,4275]
["High","O43159","ribosomal rna-processing protein 8 [OS=Homo sapiens]",22,8,17,8,456,50.7,9.42,31.67,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RRP8","ENSG00000132275","","SIRT1 negatively regulates rRNA expression","",698.3,727.7,698.1,774.5,689.5,706.5,0.9786224372264455,-0.031175734552295616,0.6072166448374365,0.21665633220155223,0.7822385023743119,0.10666081155292692,6061]
["High","O43164","E3 ubiquitin-protein ligase Praja-2 [OS=Homo sapiens]",19,8,12,7,708,78.2,4.39,16.29,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","PJA2","ENSG00000198961","","Antigen processing: Ubiquitination & Proteasome degradation","",166.7,141.4,150.2,228.4,183.8,181.4,0.7720687331536389,-0.37319880624649054,0.056681629782235794,1.2465576708583148,0.20236404450832057,0.6938666492373164,2187]
["High","O43166-1","Signal-induced proliferation-associated 1-like protein 1 [OS=Homo sapiens]",3,5,5,5,1804,199.9,8.19,7.08,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","SIPA1L1","ENSG00000197555","","Neurexins and neuroligins","Rap1 signaling pathway",445.9,445.3,431.2,450.3,470,465.8,0.9540437197893371,-0.067872714528663,0.05057221445642477,1.2960880290617536,0.18956689893219617,0.7222374943508639,2083]
["High","O43167-1","Zinc finger and BTB domain-containing protein 24 [OS=Homo sapiens]",6,4,5,4,697,78.2,7.61,11.48,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB24","ENSG00000112365","","","",113,129,143.3,142.6,148.8,138.4,0.8964634713820383,-0.15768329676823326,0.18437022272438852,0.7343092196747302,0.39899187888914234,0.3990359438859989,3608]
["High","O43169","Cytochrome b5 type B [OS=Homo sapiens]",64,6,33,6,146,16.3,4.97,87.14,"","other membranes","other molecular function","","","","","",931.9,1063.8,1093.9,929.5,1100.5,933.6,1.0425158590902954,0.060069330583026326,0.6060602413165936,0.21748420558439957,0.7813933890686862,0.10713026741778049,6056]
["High","O43172-2","Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",37,16,46,16,521,58.3,7.42,115.97,"","","","PRPF4","","","","",1980.6,2068.8,1894.9,1906.1,1836.5,1918.3,1.0500627108763625,0.07047548976637082,0.1686515806000974,0.7730095842543012,0.3804771861674547,0.41967137888979344,3461]
["High","O43175","D-3-phosphoglycerate dehydrogenase [OS=Homo sapiens]",65,24,440,24,533,56.6,6.71,1021.72,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PHGDH","ENSG00000092621","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",13938.4,13895,13617,13721.8,13612.2,13820.3,1.0071948739256895,0.010342845654866857,0.44731459553484254,0.3493869308977053,0.6651366143469911,0.17708914452612687,5251]
["High","O43181","NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [OS=Homo sapiens]",17,3,8,3,175,20.1,10.3,11.75,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity","NDUFS4","ENSG00000164258","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",276.1,301.1,283.2,313.4,312,305.9,0.9238698593364115,-0.11423845375821885,0.03857963964483056,1.4136418332238219,0.1644267611063521,0.7840274978970181,1832]
["High","O43237","Cytoplasmic dynein 1 light intermediate chain 2 [OS=Homo sapiens]",24,9,23,9,492,54.1,6.38,49.13,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYNC1LI2","ENSG00000135720","Intraflagellar transport proteins binding to dynein","COPI-mediated anterograde transport; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection",520.4,512.6,549.1,507.4,515.4,489.9,1.0458782309777221,0.0647148919377094,0.1596169490240067,0.7969209947097455,0.36916147451997755,0.43278362800472764,3376]
["High","O43242","26S proteasome non-ATPase regulatory subunit 3 [OS=Homo sapiens]",52,26,184,26,534,60.9,8.44,350.11,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity","PSMD3","ENSG00000108344","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Ub-specific processing proteases; Degradation of beta-catenin by the destruction complex; Degradation of AXIN; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",5983.3,5958,6340.2,5895.7,6381,6194.2,0.9897460329491252,-0.014869715158985813,0.7534068543437418,0.12297043299109614,0.8744760991104409,0.058252056015262926,6727]
["High","O43251-8","Isoform 8 of RNA binding protein fox-1 homolog 2 [OS=Homo sapiens]",13,4,13,4,451,47.3,6.62,36.56,"","","","RBFOX2","","","","",226.4,223.4,218.9,273.5,256.7,255,0.8516301579215486,-0.23170105548526257,0.00350240468197296,2.4556336752160526,0.04780904852595258,1.3204898993504415,572]
["High","O43252","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [OS=Homo sapiens]",51,23,86,22,624,70.8,6.86,180.9,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS1","ENSG00000138801","Sulfation biotransformation reaction","Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways",3337.1,3397.3,3513.8,3298.2,3419.5,3388.1,1.0140909180866435,0.020187002629887808,0.49524593545427303,0.305179080084265,0.7029413313991936,0.15308092037539556,5501]
["High","O43257","zinc finger HIT domain-containing protein 1 [OS=Homo sapiens]",15,1,1,1,154,17.5,9.41,2.48,"cell organization and biogenesis","nucleus","other molecular function","ZNHIT1","ENSG00000106400","","","",11.5,16.1,12,14.8,13.8,12.8,0.9565217391304347,-0.06413033741971574,0.7213365209343019,0.14186207912461435,0.8562170196799984,0.0674161436126148,6578]
["High","O43264","Centromere/kinetochore protein zw10 homolog [OS=Homo sapiens]",29,17,52,17,779,88.8,6.27,88.63,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity","ZW10","ENSG00000086827","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",1418.2,1364.3,1476.2,1522.7,1573.8,1587.2,0.9092597732561863,-0.1372355671924955,0.020014005530361537,1.6986659845449523,0.11609907517166633,0.935171239774275,1346]
["High","O43272","Proline dehydrogenase 1, mitochondrial [OS=Homo sapiens]",23,8,13,8,600,68,7.87,30.11,"other metabolic processes;stress response;signal transduction;other biological processes","other membranes;mitochondrion;nucleus;other cell component","other molecular function","PRODH","ENSG00000100033","22q11.2 copy number variation syndrome","Proline catabolism","Arginine and proline metabolism; Metabolic pathways",296.7,276.8,314,235.7,307.2,256.7,1.1099299649824912,0.15046864742214144,0.2854548573889398,0.5444625625039803,0.5167705834669237,0.2867022159912965,4313]
["High","O43278","Kunitz-type protease inhibitor 1 [OS=Homo sapiens]",4,2,2,2,529,58.4,6.29,5.43,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","enzyme regulator activity","SPINT1","ENSG00000166145","","MET Receptor Activation; Signaling by MST1","Transcriptional misregulation in cancer; Prostate cancer",96.4,82.7,95.4,120.6,108.3,122.3,0.7816059225512528,-0.3554866956427972,0.014861315895020513,1.8279427342736725,0.09985985758030995,1.000609057669349,1162]
["High","O43286","Beta-1,4-galactosyltransferase 5 [OS=Homo sapiens]",8,2,2,2,388,45.1,8.15,3.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","B4GALT5","ENSG00000158470","","N-Glycan antennae elongation; Keratan sulfate biosynthesis; O-linked glycosylation of mucins","Mucin type O-glycan biosynthesis; Metabolic pathways",38.6,47.2,48.3,65.1,81.1,80.9,0.5904887714663145,-0.7600184688024136,0.007167948885781977,2.1446051002630604,0.06702676035950379,1.1737517710880272,835]
["High","O43290","U4/U6.U5 tri-snRNP-associated protein 1 [OS=Homo sapiens]",48,33,95,33,800,90.2,6.13,228.79,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","SART1","ENSG00000175467","","mRNA Splicing - Major Pathway","Spliceosome",3789,3641.6,3575.2,3804.8,3481.3,3661.3,1.0053345999963461,0.007675745598248442,0.8714920724182472,0.05973655912274226,0.9345708146465698,0.02938778551570403,7281]
["High","O43291","Kunitz-type protease inhibitor 2 [OS=Homo sapiens]",20,4,7,4,252,28.2,8.29,13.65,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity","SPINT2","ENSG00000167642","","MET Receptor Activation; Signaling by MST1","",332.8,352.5,322.5,344.4,360.5,342.7,0.96200840015273,-0.05587860338084354,0.27385978325647936,0.5624717398971034,0.5043153744496677,0.2972977918312006,4240]
["High","O43293-1","Death-associated protein kinase 3 [OS=Homo sapiens]",26,8,16,8,454,52.5,6.89,29.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","DAPK3","ENSG00000167657; ENSPTRG00000010286","Bladder cancer","Caspase activation via Dependence Receptors in the absence of ligand","Autophagy; Pathways in cancer; Bladder cancer",461.1,442.1,398.7,419.8,395.1,385.5,1.0845551482839053,0.11710341412853732,0.1841651084643709,0.7347926468685135,0.39876904239872657,0.39927856459626127,3606]
["High","O43295","SLIT-ROBO Rho GTPase-activating protein 3 [OS=Homo sapiens]",2,2,2,2,1099,124.4,6.68,6.04,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity","SRGAP3","ENSG00000196220","","CDC42 GTPase cycle; RAC1 GTPase cycle; Inactivation of CDC42 and RAC1","Axon guidance",56,56.1,47.1,63.1,69.8,61,0.821041774110366,-0.2844724675631438,0.04425524679456744,1.354035233014808,0.17793252676209195,0.7497446539281586,1942]
["High","O43296","Zinc finger protein 264 [OS=Homo sapiens]",3,1,1,1,627,70.5,7.49,4.98,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF264","ENSG00000083844","","Generic Transcription Pathway","",22.8,21.1,24.2,16.3,8.2,20.5,1.5133333333333334,0.5977297967950342,0.10719717935753459,0.9698166419340545,0.2939921237877169,0.5316643044223742,2847]
["High","O43298","Zinc finger and BTB domain-containing protein 43 [OS=Homo sapiens]",4,2,2,2,467,52.6,5.76,2.27,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB43","ENSG00000169155","","","",108.9,99.2,107.8,119.2,88.7,117.7,0.9702088452088452,-0.04363276251937397,0.7711734038184149,0.11284795676870796,0.8836692012054864,0.053710281341931114,6814]
["High","O43301","Heat shock 70 kDa protein 12A [OS=Homo sapiens]",8,4,7,4,675,74.9,6.77,0,"","nucleus;other cell component","other molecular function","HSPA12A","ENSG00000165868","","Regulation of HSF1-mediated heat shock response","",291.5,237.4,357.5,253.4,327.5,283.3,1.0256884980328627,0.03659265045945449,0.8650763240293678,0.06294557387334157,0.9332019809369031,0.030024347986886666,7238]
["High","O43303","centriolar coiled-coil protein of 110 kDa [OS=Homo sapiens]",6,4,4,4,1012,113.4,8.65,8.68,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cell component","","CCP110","ENSG00000103540","Joubert syndrome","Ub-specific processing proteases; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; RHOV GTPase cycle","",190.1,179.3,168.7,181.1,169.7,163.8,1.0456665371162068,0.06442284972097406,0.3827560337815449,0.4170779543400201,0.6112822891728988,0.2137581869452203,4889]
["High","O43310","CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",10,4,4,4,598,67.5,6.54,5.41,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","CTIF","ENSG00000134030; ENSG00000282825","","","",82.6,91.1,100.9,97.1,85.8,75.9,1.0610510046367856,0.08549400815459367,0.550587171772359,0.25917391152855684,0.746481096926303,0.12698118539982778,5759]
["High","O43314-1","inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 [OS=Homo sapiens]",12,12,15,12,1243,140.3,8.22,33.34,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","PPIP5K2","ENSG00000145725","","Synthesis of pyrophosphates in the cytosol","Phosphatidylinositol signaling system",671.9,624,709.7,722.5,718.4,706.1,0.9341406613879834,-0.09828828991219613,0.13571711975571016,0.867365365704453,0.336940944690806,0.4724462108271054,3145]
["High","O43318","mitogen-activated protein kinase kinase kinase 7 [OS=Homo sapiens]",5,4,5,4,606,67.2,7.11,2.45,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","signal transduction activity or receptor binding;kinase activity;other molecular function","MAP3K7","ENSG00000135341","IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL-6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway","Downstream TCR signaling; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway","MAPK signaling pathway; NF-kappa B signaling pathway; Autophagy; AMPK signaling pathway; Wnt signaling pathway; Osteoclast differentiation; Adherens junction; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; T cell receptor signaling pathway; TNF signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Leishmaniasis; Toxoplasmosis; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",339.5,352.3,333.4,348.8,298.1,347.2,1.0312845790161953,0.044442493796095356,0.5864239248716833,0.23178831969742766,0.76902888904906,0.1140573453494982,5954]
["Low","O43323","desert hedgehog protein [OS=Homo sapiens]",2,1,1,1,396,43.6,9.28,0,"cell-cell signaling;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","DHH","ENSG00000139549","Hedgehog signaling pathway; Hedgehog signaling pathway; Somatic sex determination; Mammalian disorder of sexual development","Release of Hh-Np from the secreting cell; Activation of SMO; Class B/2 (Secretin family receptors); Ligand-receptor interactions; HHAT G278V doesn't palmitoylate Hh-Np; Transcriptional regulation of testis differentiation","Hedgehog signaling pathway",39.5,31.7,30.1,51.5,36.8,40.4,0.7871017871017872,-0.3453778794195633,0.1594261289033756,0.7974404990716417,0.3691575369150524,0.43278826036571105,3372]
["High","O43324-1","Eukaryotic translation elongation factor 1 epsilon-1 [OS=Homo sapiens]",43,6,18,6,174,19.8,8.54,38.05,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EEF1E1","ENSANAG00000036153; ENSG00000124802; ENSPTRG00000017709","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","",770.7,737.2,721.7,853.7,813.5,818.1,0.8971150364141152,-0.1566351021362626,0.011436253341598781,1.9417162324991033,0.08728667262092207,1.0590520615526282,1023]
["High","O43347","RNA-binding protein Musashi homolog 1 [OS=Homo sapiens]",25,7,21,6,362,39.1,7.85,39.55,"developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MSI1","ENSG00000135097","","Regulation of expression of SLITs and ROBOs","mRNA surveillance pathway",851.9,836.1,873.1,971.5,1065.2,1009.4,0.8407800137881224,-0.2501997195352567,5.233114389095221E-3,2.281239772042317,0.05738786116580827,1.241179961020538,712]
["Medium","O43353-1","Receptor-interacting serine/threonine-protein kinase 2 [OS=Homo sapiens]",1,1,1,1,540,61.2,7.09,2.02,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","RIPK2","ENSG00000104312","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor (TCR) signaling pathway","Downstream TCR signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases","NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Shigellosis; Salmonella infection; Tuberculosis",36.8,32.5,30.1,48.8,48.9,40.7,0.7182080924855493,-0.47752618607443814,0.017831511786353567,1.748811835027774,0.11041113721478878,0.9569871169422202,1261]
["High","O43379-1","Wd repeat-containing protein 62 [OS=Homo sapiens]",4,5,6,1,1518,165.8,5.91,8.62,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;nucleus","","WDR62","ENSG00000075702","","","",176.2,180.7,158.8,185.9,166.1,167,0.9936416184971099,-0.009202493046025884,0.9114307707565923,0.04027631331753079,0.954331696133495,0.020300651749546997,7457]
["High","O43390-1","heterogeneous nuclear ribonucleoprotein r [OS=Homo sapiens]",58,28,215,20,633,70.9,8.13,525.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","Hnrnpr; HNRNPR; LOC111154612","ENSAMEG00000009537; ENSCAFG00000013308; ENSCANG00000026442; ENSCATG00000035305; ENSFCAG00000019123; ENSG00000125944; ENSG00000282958; ENSGGOG00000013250; ENSLCNG00005013650; ENSMFAG00000039737; ENSMMUG00000010970; ENSMPUG00000015898; ENSNLEG00000008411; ENSRROG00000036942; ENSSSUG00005005658; ENSUAMG00000027050; ENSUMAG00000013292","mRNA Processing; mRNA processing","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","",4547.4,4462.8,4670.1,4761.6,4992.2,4991.2,0.9277924720244152,-0.10812595447359982,0.021957788859180753,1.6584113953059674,0.12056709944619082,0.9187711870410793,1422]
["High","O43395","U4/U6 small nuclear ribonucleoprotein Prp3 [OS=Homo sapiens]",42,25,86,25,683,77.5,9.5,169.89,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","PRPF3","ENSG00000117360","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",3614.9,3481.8,3527.7,3873.6,3555.1,3684.2,0.9560420772255669,-0.06485397953826556,0.18012177263558335,0.744433787658116,0.392956356730549,0.40565568138948477,3579]
["High","O43396","Thioredoxin-like protein 1 [OS=Homo sapiens]",52,12,49,12,289,32.2,4.96,135.55,"","cytosol;nucleus;other cell component","other molecular function","TXNL1","ENSG00000091164","","RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle","",1919.6,2113.7,1999.5,2071.4,1957.1,2049.9,0.9924980257962621,-0.010863862331288355,0.8300340234039888,0.08090410536637999,0.917195818672282,0.03753793380657129,7066]
["High","O43399","Tumor protein D54 [OS=Homo sapiens]",60,9,25,9,206,22.2,5.36,49.43,"other metabolic processes;other biological processes","other cell component","other molecular function","TPD52L2","ENSG00000101150","","","",936.2,1008.7,950.4,993.1,939.7,867.2,1.0340357142857142,0.04828601537535955,0.4982096140266342,0.3025878960720334,0.7044586501847084,0.1521444937166424,5522]
["High","O43402","ER membrane protein complex subunit 8 [OS=Homo sapiens]",42,7,21,7,210,23.8,6.4,44.2,"cell organization and biogenesis","other membranes;cytosol;ER/Golgi;other cell component","","EMC8","ENSG00000131148","","","",615.7,597.4,583,585.8,572.6,592.9,1.0255809969736764,0.03644143556984803,0.2524355601271329,0.5978494668637778,0.4814403647954699,0.3174575005316293,4094]
["High","O43414-1","ERI1 exoribonuclease 3 [OS=Homo sapiens]",3,1,4,1,337,37.2,8.07,8.71,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","ERI3","ENSG00000117419; ENSMFAG00000044436; ENSMLEG00000012810; ENSMMUG00000011651; ENSMNEG00000035539; ENSNLEG00000014004; ENSPANG00000013867; ENSPPAG00000042776; ENSPTRG00000000655; ENSRBIG00000044795; ENSRROG00000036414","","","",234.8,232.4,223.9,266.2,249,263.1,0.887960940511371,-0.17143187796277454,0.009607871838311454,2.0173727987239425,0.07880069675791579,1.1034699424497816,952]
["High","O43422-1","52 kDa repressor of the inhibitor of the protein kinase [OS=Homo sapiens]",10,4,6,4,761,87.6,5.86,13.15,"other metabolic processes;signal transduction;other biological processes","","nucleic acid binding activity;kinase activity;other molecular function","THAP12","ENSG00000137492; ENSPTRG00000004091","","","",72.5,73.9,94.5,73.1,74.9,76.1,{"$f":"AVERAGE(T386:V386)/AVERAGE(W386:Y386)","v":1.074966532797858},{"$f":"LOG(Z386,2)","v":0.10429174472807712},{"$f":"TTEST(T386:V386,W386:Y386,2,2)","v":0.4781212188347637},{"$f":"-LOG10(AB386)","v":0.32046198205538556},{"$f":"AB386*7808/AF386","v":0.6895401693132315},{"$f":"-LOG10(AD386)","v":0.16144042883123774},5414]
["High","O43426","Synaptojanin-1 [OS=Homo sapiens]",6,7,8,7,1573,173,7.42,17.28,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ1","ENSG00000159082","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway","Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Clathrin-mediated endocytosis; Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",247.4,247,253.2,187.9,200.1,207.7,1.2549941245593417,0.32768061000159093,1.1539543259269842E-3,2.937811380426761,0.029541230743730797,1.5295714151149116,305]
["High","O43427","Acidic fibroblast growth factor intracellular-binding protein [OS=Homo sapiens]",23,8,15,8,364,41.9,6.48,25.79,"signal transduction","other membranes;mitochondrion;nucleus;other cell component","other molecular function","FIBP","ENSG00000172500","Modulators of TCR signaling and T cell activation","","",747.8,768.1,807.4,770.4,804.5,753.4,0.9978525104153245,-3.1015039911493074E-3,0.9458525354368641,0.024176567655448795,0.9734040591394537,0.01170684706088057,7587]
["High","O43432","Eukaryotic translation initiation factor 4 gamma 3 [OS=Homo sapiens]",23,32,66,25,1585,176.5,5.38,113.78,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","nucleic acid binding activity","EIF4G3","ENSG00000075151","Translation factors; Translation inhibitors in chronically activated PDGFRA cells","ISG15 antiviral mechanism","Viral myocarditis",1554.5,1526.1,1572.8,1667.7,1591.8,1654.6,0.9469485765450437,-0.07864201172568819,0.032614819639454014,1.4865850187912393,0.15015124513258074,0.8234710620532989,1696]
["High","O43439","Protein CBFA2T2 [OS=Homo sapiens]",3,2,4,2,604,67.1,8.05,10.01,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","other molecular function","CBFA2T2","ENSG00000078699","","","",229.4,235.8,211.4,241.9,222.5,215.1,0.9957321559970567,-6.170373860765359E-3,0.9331432109476973,0.030051699285170638,0.9664388103302322,0.014825637938773652,7539]
["High","O43447","peptidyl-prolyl cis-trans isomerase H [OS=Homo sapiens]",52,9,51,8,177,19.2,8.07,58.75,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PPIH","ENSG00000171960","","mRNA Splicing - Major Pathway","Spliceosome",1731.8,1753.9,1707.8,1774.6,1707.3,1749.7,0.9927173331294442,-0.010545112426521687,0.6208994101426302,0.20697875273562816,0.7906038151326903,0.10204109425933028,6132]
["Medium","O43462","Membrane-bound transcription factor site-2 protease [OS=Homo sapiens]",2,1,1,1,519,57.4,7.49,2.45,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MBTPS2","ENSG00000012174","Sterol regulatory element-binding proteins (SREBP) signaling; Type I collagen synthesis in the context of osteogenesis imperfecta; Unfolded protein response","Regulation of cholesterol biosynthesis by SREBP (SREBF); ATF6 (ATF6-alpha) activates chaperones; CREB3 factors activate genes; Assembly of active LPL and LIPC lipase complexes","Protein processing in endoplasmic reticulum",39.1,39.8,34.6,35.7,37.9,41.9,0.9826839826839827,-0.025200554125142514,0.798111961351708,0.09793618034537915,0.8980628612529379,0.046693263177025636,6939]
["High","O43463","Histone-lysine N-methyltransferase SUV39H1 [OS=Homo sapiens]",3,1,2,1,412,47.9,8.03,7.6,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SUV39H1","ENSG00000101945","Histone modifications; Retinoblastoma gene in cancer; Interactions between LOXL4 and oxidative stress pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","PKMTs methylate histone lysines; SIRT1 negatively regulates rRNA expression","Lysine degradation; Metabolic pathways",83.8,87.7,84,93,117.7,107.9,0.8019460138104206,-0.31842297570032607,0.044809959247625965,1.3486254510554732,0.17933170774242108,0.7463429157913557,1951]
["High","O43464","Serine protease HTRA2, mitochondrial [OS=Homo sapiens]",22,6,12,6,458,48.8,10.07,17.97,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HTRA2","ENSG00000115317","Apoptosis modulation and signaling; Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity","","Apoptosis; Apoptosis; Parkinson disease; Pathways of neurodegeneration",39,36.2,36,35.2,37.2,31.8,1.0671785028790788,0.09380151044499933,0.2757427919127105,0.5594958314660139,0.5064690000598551,0.2954471317745013,4251]
["High","O43482","Protein Mis18-beta [OS=Homo sapiens]",10,2,2,2,229,24.7,7.37,2.03,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","other molecular function","OIP5","ENSG00000104147","","Deposition of new CENPA-containing nucleosomes at the centromere","",83.7,77.7,77.3,100.2,88.1,100.1,0.8276699029126214,-0.2728725981590458,0.021462326451739882,1.6683232036006925,0.11927248749835231,0.9234597231831558,1405]
["High","O43488","aflatoxin B1 aldehyde reductase member 2 [OS=Homo sapiens]",18,6,11,6,359,39.6,7.17,9.95,"other metabolic processes","cytosol;ER/Golgi","other molecular function","AKR7A2","ENSG00000053371","Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II","Aflatoxin activation and detoxification","Metabolism of xenobiotics by cytochrome P450",473.4,474.4,479.8,448.9,478.2,440.2,1.0441015139325678,0.06226198635924041,0.15996803100485127,0.7959668007529532,0.3695356171851712,0.43234369637197256,3380]
["High","O43490-1","Prominin-1 [OS=Homo sapiens]",6,4,4,4,865,97.1,7.27,8.05,"developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","PROM1","ENSG00000007062","Extracellular vesicle-mediated signaling in recipient cells","","Transcriptional misregulation in cancer",42.5,51,50.9,55.4,57.4,54,0.8657074340527577,-0.20804854655749272,0.06664256461631375,1.1762482982567048,0.22076586530512418,0.6560680761223933,2357]
["High","O43491-1","band 4.1-like protein 2 [OS=Homo sapiens]",54,50,238,7,1005,112.5,5.44,509.23,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","EPB41L2","ENSG00000079819","Splicing factor NOVA regulated synaptic proteins","Neurexins and neuroligins","",9237.5,8934.7,9096.1,10077.3,9320.1,9736.8,0.9359549944738488,-0.09548893560264828,0.05770656537340567,1.238774773616597,0.20434143421113446,0.6896435627618189,2205]
["High","O43491-4","Isoform 4 of Band 4.1-like protein 2 [OS=Homo sapiens]",54,44,189,1,852,95.5,5.77,395.37,"","","","EPB41L2","","","","",18,7.1,14.7,26.8,18.9,20.7,0.5993975903614457,-0.7384148108032762,0.09185168136596643,1.0369128894259145,0.2694131961327821,0.5695811359059354,2662]
["High","O43493-1","Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",26,11,21,11,480,51.1,5.73,42.75,"","","","","","","","",1040,957.7,1006.2,1079.1,988.1,1048.1,0.9642410040766541,-0.05253431364913058,0.35858318564517966,0.4454100788360804,0.5919275927098442,0.22773141491525653,4730]
["High","O43502","DNA repair protein RAD51 homolog 3 [OS=Homo sapiens]",5,2,2,2,376,42.2,6.74,5.99,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD51C","ENSG00000108384","DNA repair pathways, full network","Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination","Homologous recombination; Fanconi anemia pathway",31.6,117.6,46.7,48.2,49.7,47.2,1.350103376981392,0.4330698782008423,0.5578775183722969,0.25346113965359063,0.7511480709520425,0.12427444374317066,5799]
["High","O43504","Ragulator complex protein LAMTOR5 [OS=Homo sapiens]",11,1,3,1,91,9.6,4.87,9.14,"cell organization and biogenesis;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","LAMTOR5","ENSG00000134248","","Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","mTOR signaling pathway",73.7,80.5,68.8,106.1,69.6,79.5,0.8738244514106583,-0.19458461895720222,0.40026625522536163,0.39765102190378615,0.62693659394175,0.20277637989282524,4985]
["High","O43505","beta-1,4-glucuronyltransferase 1 [OS=Homo sapiens]",11,4,6,4,415,47.1,7.2,12.9,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B4GAT1","ENSG00000174684","","Keratan sulfate biosynthesis; Defective LARGE causes MDDGA6 and MDDGB6; O-linked glycosylation","Mannose type O-glycan biosynthesis; Metabolic pathways",305.9,354.1,320.1,494.9,464.1,520.2,0.6625878853434288,-0.5938162692449768,1.5354651258279917E-3,2.8137600429997858,0.03222825726469075,1.491763178223048,372]
["High","O43524","Forkhead box protein O3 [OS=Homo sapiens]",2,1,1,1,673,71.2,5.16,2.2,"RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXO3","ENSG00000118689","IL-5 signaling pathway; Energy metabolism; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Kit receptor signaling pathway; Copper homeostasis; NAD metabolism, sirtuins and aging; Imatinib and chronic myeloid leukemia; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Non-small cell lung cancer; Leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; DNA damage response (only ATM dependent)","MAPK6/MAPK4 signaling; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by NODAL; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; FoxO signaling pathway; Mitophagy; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Neurotrophin signaling pathway; Prolactin signaling pathway; Alcoholic liver disease; Shigellosis; Chemical carcinogenesis; Endometrial cancer; Non-small cell lung cancer",24.3,20.3,23.8,32.5,23.2,27.1,0.826086956521739,-0.27563444261342757,0.18199821828032986,0.739932863634753,0.3961645074805731,0.40212443565208406,3587]
["Medium","O43529","Carbohydrate sulfotransferase 10 [OS=Homo sapiens]",2,1,1,1,356,42.2,8.03,2.54,"cell adhesion;protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST10","ENSG00000115526","Metapathway biotransformation Phase I and II","Reactions specific to the complex N-glycan synthesis pathway","Mannose type O-glycan biosynthesis; Metabolic pathways",67.6,50.3,70,57.8,76.4,63.4,0.9509109311740891,-0.0726178801646221,0.7166547359499272,0.1446900247867194,0.8526040192437958,0.06925262438500715,6563]
["High","O43542","DNA repair protein XRCC3 [OS=Homo sapiens]",6,2,2,2,346,37.8,8.48,5,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","XRCC3","ENSG00000126215","Fluoropyrimidine activity; Male infertility","Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange","Homologous recombination",72.9,88.2,74.2,90.5,82.5,89,0.8980916030534352,-0.15506549120051502,0.17959563881548218,0.7457042136674186,0.3924664841509334,0.4061974252112231,3573]
["High","O43567","E3 ubiquitin-protein ligase RNF13 [OS=Homo sapiens]",6,1,2,1,381,42.8,4.98,2.91,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RNF13","ENSG00000082996","","","",69.2,62.2,56.1,49.5,59,74.2,1.026272577996716,0.03741396164311694,0.8535445654934453,0.06877379845949316,0.9291058089185585,0.03193482463629499,7173]
["High","O43572","A-kinase anchor protein 10, mitochondrial [OS=Homo sapiens]",7,3,5,3,662,73.8,6.39,5.68,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","AKAP10","ENSG00000108599","G protein signaling pathways","Factors involved in megakaryocyte development and platelet production","",39.2,42.3,37.2,42.5,38.6,40.2,0.9785655399835121,-0.03125961547860329,0.6664895449184627,0.17620665888302958,0.8205535109939067,0.0858930919154641,6342]
["High","O43583","density-regulated protein [OS=Homo sapiens]",22,5,19,5,198,22.1,5.3,47.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","","nucleic acid binding activity","DENR","ENSG00000139726","","","",778.1,791,753.7,1191.7,808.9,788.1,0.832932907806505,-0.2637278027455936,0.3035387580647726,0.5177858471291817,0.5363273643289759,0.2705700440328397,4419]
["High","O43592","Exportin-T [OS=Homo sapiens]",26,19,39,19,962,109.9,5.39,77.6,"transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPOT","ENSG00000184575","","tRNA processing in the nucleus","Nucleocytoplasmic transport",1294.9,1379.4,1411,1335.5,1581.2,1433.6,0.939084660827989,-0.09067286858346718,0.32811465675187634,0.4839743694180009,0.5601047747963818,0.25173072503009525,4574]
["Medium","O43593-1","lysine-specific demethylase hairless [OS=Homo sapiens]",2,1,1,1,1189,127.4,7.08,0,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HR","ENSG00000168453","","","",33.4,32.8,38.9,35.2,37.2,39.2,0.9417562724014336,-0.08657435786700937,0.3917267287876259,0.40701679411735375,0.6212882994868542,0.206706825231474,4923]
["High","O43597","Protein sprouty homolog 2 [OS=Homo sapiens]",6,2,3,2,315,34.7,8.35,9.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","SPRY2","ENSG00000136158","Glioblastoma signaling pathways; Ectoderm differentiation; EGF/EGFR signaling pathway","EGFR downregulation; Spry regulation of FGF signaling","MicroRNAs in cancer",111.9,134.2,113.1,249.2,229.2,249,0.493813582623041,-1.0179615757144698,2.3580437427286473E-4,3.6274481428162177,0.014729284434580223,1.831818351165639,125]
["High","O43598-1","2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [OS=Homo sapiens]",32,5,17,5,174,19.1,5.05,19.41,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","C6orf108; DNPH1","ENSG00000112667","","Purine catabolism","",798.1,736.1,730.4,825.4,796.7,732.7,0.9616952607440121,-0.056348285572791756,0.4380069307744128,0.35851901741081277,0.6578107550464733,0.18189903018575682,5199]
["High","O43602","Neuronal migration protein doublecortin [OS=Homo sapiens]",10,2,2,2,365,40.5,9.28,2.77,"cell organization and biogenesis;developmental processes;signal transduction","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DCX","ENSG00000077279","","Neurofascin interactions","",122.4,122.6,104.9,117,118.4,104.7,1.0288150543957657,0.040983658532007194,0.6778873753138075,0.16884245413098206,0.8274104465296559,0.08227900018990933,6397]
["High","O43615","Mitochondrial import inner membrane translocase subunit TIM44 [OS=Homo sapiens]",52,24,96,24,452,51.3,8.32,201.09,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus","other molecular function","TIMM44","ENSG00000104980","","Mitochondrial protein import","",3639.9,4130.7,3732,3735.9,3845,3829.1,1.0081156879929887,0.011661207207692656,0.8513107755591047,0.0699118694430086,0.9279679653169747,0.032467015942995024,7163]
["High","O43617-1","Trafficking protein particle complex subunit 3 [OS=Homo sapiens]",42,9,25,9,180,20.3,4.96,40.56,"transport","other membranes;cytosol;ER/Golgi;other cell component","","TRAPPC3","ENSCANG00000028241; ENSCATG00000041647; ENSCSAG00000001096; ENSG00000054116; ENSGGOG00000004752; ENSMMUG00000022499; ENSMNEG00000014589; ENSPPAG00000041117; ENSPPYG00000001546; ENSRBIG00000043692; ENSRROG00000034420","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",1733.8,1595.2,1791.2,1695.5,1830.3,1640.2,0.9911343399148277,-0.012847479056263439,0.859789481724219,0.06560787214884711,0.9316175788652098,0.03076232527676139,7206]
["High","O43633","charged multivesicular body protein 2a [OS=Homo sapiens]",14,3,5,3,222,25.1,5.97,7.85,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","CHMP2A","ENSG00000130724","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Endocytosis; Necroptosis",223.4,215.3,221.8,233.3,197.3,196.6,1.0530931122448979,0.07463300201898165,0.4202299523807284,0.37651299598034343,0.6443746009797187,0.1908615863033258,5092]
["High","O43639","Cytoplasmic protein NCK2 [OS=Homo sapiens]",23,8,13,7,380,42.9,6.95,29.84,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NCK2","ENSG00000071051","Pathogenic Escherichia coli infection; Brain-derived neurotrophic factor (BDNF) signaling pathway; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; ErbB signaling pathway","RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Ephrin signaling; Activation of RAC1; Regulation of cortical dendrite branching","ErbB signaling pathway; Axon guidance; T cell receptor signaling pathway; Pathogenic Escherichia coli infection",451.1,422.1,419.1,453.9,401.6,426.9,1.007719900187149,0.011094691649167567,0.8651135276541069,0.0629268969299787,0.9331131957346687,0.030065668899791564,7239]
["High","O43657","Tetraspanin-6 [OS=Homo sapiens]",20,6,20,6,245,27.5,8.1,46.7,"other biological processes","plasma membrane;other membranes","","TSPAN6","ENSG00000000003","","","",660.1,906.8,623.9,580.6,513.2,596.7,1.2959479443951494,0.37400776924779766,0.14571442034481188,0.8364974669926597,0.35082892200193994,0.45490461100699703,3243]
["High","O43660-1","Pleiotropic regulator 1 [OS=Homo sapiens]",37,13,32,13,514,57.2,9.17,67.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","","PLRG1","ENSG00000171566","","mRNA Splicing - Major Pathway","Spliceosome",1119.3,1223.9,1224.5,1135.3,1258.5,1225.6,0.9857158645079295,-0.020756249440485156,0.7514201692497587,0.12411715199779304,0.8749013840593671,0.05804089643195891,6706]
["High","O43663-1","Protein regulator of cytokinesis 1 [OS=Homo sapiens]",24,12,21,12,620,71.6,6.68,31.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","PRC1","ENSG00000198901","","RHO GTPases activate CIT","",458,468.2,507.9,534.7,603.1,591.2,0.8294389820705609,-0.26979224209936936,0.019460838771054,1.7108384453734202,0.11599254131632797,0.9355699363705491,1310]
["High","O43670-1","BUB3-interacting and GLEBS motif-containing protein ZNF207 [OS=Homo sapiens]",16,8,37,8,478,50.7,9.1,88.14,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","LOC111151255; Znf207; ZNF207","ENSAMEG00000005671; ENSANAG00000033773; ENSCANG00000036057; ENSCJAG00000014376; ENSECAG00000017464; ENSG00000010244; ENSGGOG00000024003; ENSMFAG00000001904; ENSMLEG00000018149; ENSMMUG00000016875; ENSMNEG00000041308; ENSNLEG00000005954; ENSOCUG00000008195; ENSPCOG00000020744; ENSPPAG00000032098; ENSPTRG00000008989; ENSRROG00000037743; ENSSBOG00000026038; ENSSTOG00000000712","","","",1273.4,1278.2,1181.9,1204.6,1095.8,1188.3,1.0701694040760172,0.09783918828590622,0.15173270941887262,0.8189207871180029,0.3595535645349188,0.4442364013893961,3295]
["High","O43674-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [OS=Homo sapiens]",21,4,13,4,189,21.7,9.63,29.64,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB5","ENSG00000136521; ENSGGOG00000005222; ENSPTRG00000015649","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",768.8,709.3,767.5,731.5,768.9,754.3,0.9959639863396461,-0.005834518927894448,0.8989859003208582,0.04624711968041681,0.9482953133889841,0.02305639578087444,7402]
["High","O43676","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [OS=Homo sapiens]",11,1,3,1,98,11.4,9.2,6.82,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB3","ENSG00000119013","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",145.6,146.3,122.7,162,139.2,155,0.908811924594476,-0.1379463302027228,0.2484796699165191,0.6047091385373194,0.4780998675968904,0.32048137657601117,4058]
["High","O43678","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [OS=Homo sapiens]",37,3,4,3,99,10.9,9.57,6.95,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;mitochondrion","transporter activity","NDUFA2","ENSG00000131495","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",142.2,146.6,146.2,230.4,135.1,159.3,0.8288871951219512,-0.27075231899463076,0.3548607908124503,0.44994198395616386,0.5878958316706158,0.2306996190571642,4713]
["High","O43681","ATPase ASNA1 [OS=Homo sapiens]",44,10,49,10,348,38.8,4.91,98.01,"cell organization and biogenesis;transport","ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","GET3","ENSG00000198356","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",1502.6,1563,1585.9,1451.1,1552,1506.5,1.0314662054284194,0.04469655407992925,0.28463518545741745,0.5457114151952268,0.5158847558151151,0.2874473051625353,4308]
["High","O43683","Mitotic checkpoint serine/threonine-protein kinase BUB1 [OS=Homo sapiens]",18,14,36,14,1085,122.3,6.47,103.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","BUB1","ENSG00000169679","Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation",1314.9,1229.5,1297.5,903.3,942.2,936.9,1.380786371477861,0.4654901301318692,2.5265309007585756E-4,3.597475385750758,0.015411838494627312,1.812145550739991,128]
["High","O43684","Mitotic checkpoint protein BUB3 [OS=Homo sapiens]",55,13,61,13,328,37.1,6.84,138.72,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","BUB3","ENSG00000154473","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Human T-cell leukemia virus 1 infection",2199.5,2181.6,2316.5,2190.7,2426.3,2438,0.9493408929836995,-0.07500186611627972,0.2605543850141851,0.5841016134531266,0.49010085237069556,0.30971454217301064,4151]
["High","O43687-1","A-kinase anchor protein 7 isoforms alpha and beta [OS=Homo sapiens]",12,1,1,1,104,11.5,4.94,2.61,"transport;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","AKAP7","ENSG00000118507; ENSGGOG00000008778; ENSPPAG00000039914; ENSPTRG00000018599","G protein signaling pathways","","",52.6,71.1,56.7,59.4,64.4,51.7,1.0279202279202277,0.03972830806345765,0.81982555680678,0.08627854734281802,0.9128918921202707,0.03958065010593999,7012]
["High","O43688","Phospholipid phosphatase 2 [OS=Homo sapiens]",7,2,6,2,288,32.6,8.35,5.2,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","PLPP2","ENSG00000141934","Triacylglyceride synthesis","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",391.6,346.5,331,377.2,370.8,404.1,0.9279576425657494,-0.10786914110240332,0.2550820946828378,0.5933200253312361,0.4841227504335434,0.31504450803130596,4114]
["High","O43707","Alpha-actinin-4 [OS=Homo sapiens]",70,61,472,40,911,104.8,5.44,1101.64,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","ACTN4","ENSG00000130402; ENSG00000282844","Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome","Platelet degranulation ; Nephrin family interactions","Focal adhesion; Adherens junction; Tight junction; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Amoebiasis; Viral carcinogenesis; Systemic lupus erythematosus",19586.2,19849.7,18897.2,19050.5,18446.7,18438.8,1.0428543335240277,0.06053765548095645,0.08379792733325477,1.0767667231222577,0.25449016593467644,0.594328995106483,2571]
["Low","O43708","maleylacetoacetate isomerase [OS=Homo sapiens]",5,1,1,1,216,24.2,8.54,0,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","GSTZ1","ENSG00000100577","Metapathway biotransformation Phase I and II","Regulation of pyruvate dehydrogenase (PDH) complex; Glutathione conjugation; Tyrosine catabolism","Tyrosine metabolism; Metabolic pathways",14.8,17.3,17.3,18,15.7,13.5,1.0466101694915255,0.06572418222283653,0.6594768969495778,0.1808004142238489,0.8156495503536042,0.08849639889256733,6313]
["High","O43709-1","Probable 18S rRNA (guanine-N(7))-methyltransferase [OS=Homo sapiens]",16,5,9,5,281,31.9,8.73,28.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","BUD23","ENSG00000071462; ENSGGOG00000001453","7q11.23 copy number variation syndrome","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",458.3,432.3,447.2,503.9,510.6,470.3,0.9009967672413793,-0.15040616520059882,0.028201587511041595,1.5497264438834781,0.13728054568965883,0.8623910031729874,1604]
["High","O43719","HIV Tat-specific factor 1 [OS=Homo sapiens]",50,32,81,32,755,85.8,4.4,178.62,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","HTATSF1","ENSG00000102241","","","",3466.4,3269.7,3399.8,3608.1,3296.5,3527.1,0.9716441232013958,-0.04150008939436288,0.41983215519464284,0.37692430160688856,0.6440175771630199,0.1911022792850119,5090]
["High","O43739","cytohesin-3 [OS=Homo sapiens]",17,4,10,2,400,46.3,5.47,24.52,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","CYTH3","ENSG00000008256","Insulin signaling","Intra-Golgi traffic","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection",222.4,220.6,196.4,186.2,185.7,192,1.1338889874091151,0.18127940116714916,0.04330847726081674,1.3634270859272943,0.17575498464264921,0.7550923489704531,1924]
["High","O43741","5'-AMP-activated protein kinase subunit beta-2 [OS=Homo sapiens]",22,4,6,4,272,30.3,6.46,9.93,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PRKAB2","ENSG00000131791","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Caloric restriction and aging; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Carnitine metabolism; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy",323.1,347.3,356,380.5,382.8,400.6,0.8818627029813558,-0.18137403450872353,0.017353802466816046,1.7606053503012937,0.10857250774110551,0.9642801309890636,1248]
["High","O43747-1","AP-1 complex subunit gamma-1 [OS=Homo sapiens]",23,16,55,16,822,91.3,6.8,113.33,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","AP1G1","ENSCANG00000031796; ENSCCAG00000037984; ENSCJAG00000015028; ENSG00000166747; ENSGGOG00000004800; ENSMFAG00000037769; ENSMLEG00000040277; ENSMMUG00000010878; ENSMNEG00000034875; ENSPANG00000016832; ENSPPAG00000031149; ENSPTRG00000008327; ENSRBIG00000018408; ENSRROG00000025423; ENSSBOG00000025975","","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","Lysosome; Human immunodeficiency virus 1 infection",2172,2214.6,2405,2055.6,2407.8,2208.9,1.0178798914916896,0.02556733531114195,0.7655853618836331,0.11600637893280515,0.8808857214246106,0.05508042958326864,6786]
["High","O43752","Syntaxin-6 [OS=Homo sapiens]",31,4,20,4,255,29.2,4.93,32.58,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STX6","ENSG00000135823","","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","SNARE interactions in vesicular transport",212.5,223.8,211.5,203.3,192.4,178.3,1.1285714285714283,0.17449773123213616,0.04054209781163378,1.3920937829137292,0.16918904313908956,0.7716277657551036,1871]
["High","O43760","Synaptogyrin-2 [OS=Homo sapiens]",32,3,6,3,224,24.8,4.94,14.02,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","SYNGR2","ENSG00000108639","","","",186.8,194.4,203,183.6,176.8,173.7,1.0938026586781504,0.1293524739370445,0.03891030620838128,1.4099353514607902,0.16556494325615315,0.7810316153902629,1835]
["High","O43765","Small glutamine-rich tetratricopeptide repeat-containing protein alpha [OS=Homo sapiens]",38,11,72,11,313,34,4.87,137.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","SGTA","ENSG00000104969","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",3607.5,3670.6,3669.2,3594,3650.2,3444.9,1.0241554480732709,0.03443470668943873,0.25415658722509754,0.5948986297801343,0.48271822745160825,0.31630630190184866,4111]
["High","O43766-1","Lipoyl synthase, mitochondrial [OS=Homo sapiens]",2,1,1,1,372,41.9,8.59,2.72,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","LIAS","ENSG00000121897","","Glyoxylate metabolism and glycine degradation","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors",70.6,87.6,65.8,87.9,85.8,79,0.886426592797784,-0.17392693199980852,0.25123386620152144,0.5999218183062981,0.48114643789587425,0.31772272509981947,4077]
["Medium","O43768","alpha-endosulfine [OS=Homo sapiens]",12,2,2,2,121,13.4,7.24,2.11,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ENSA","ENSG00000143420","","MASTL Facilitates Mitotic Progression","",166.1,109.8,141.8,202.2,114.5,107.3,0.9851415094339621,-0.021597121287769087,0.9544982634405623,0.020224857400086373,0.9774062217631357,0.009924900760274453,7625]
["High","O43776","Asparagine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",42,23,123,23,548,62.9,6.25,267.5,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","NARS1","ENSG00000134440","Photodynamic therapy-induced unfolded protein response","Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",5073.4,5161.7,5171.5,5124,5367,5246.1,0.9789986719281188,-0.030621192161575356,0.2246148336205565,0.6485615662097849,0.4514266720487272,0.3454127846880825,3885]
["High","O43791","Speckle-type POZ protein [OS=Homo sapiens]",7,2,2,2,374,42.1,5.8,2.04,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SPOP","ENSG00000121067","mRNA processing; Hedgehog signaling pathway","Hedgehog 'on' state","Hedgehog signaling pathway",21.1,17.8,22.9,27.7,27,17.9,0.8512396694214877,-0.23236271009137605,0.3608144763275084,0.44271604634342043,0.5944797280365447,0.22586295038418622,4739]
["High","O43795","Unconventional myosin-Ib [OS=Homo sapiens]",20,21,52,21,1136,131.9,9.38,118.64,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1B","ENSG00000128641","","","Pathogenic Escherichia coli infection",2391.7,2437.6,2559.2,2328.3,2467.2,2427.8,1.0228704331815097,0.03262341072849666,0.4436250310470548,0.35298395725029247,0.6619194042452521,0.1791948873313223,5233]
["High","O43808","peroxisomal membrane protein PMP34 [OS=Homo sapiens]",3,1,2,1,307,34.5,10.08,5.73,"other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","SLC25A17","ENSG00000100372","","Class I peroxisomal membrane protein import; Alpha-oxidation of phytanate","Peroxisome",94.7,90.1,104,89.1,97.2,97.9,1.0161857846586908,0.023164187644390283,0.7730352053659283,0.11180072710626028,0.8851530845427729,0.05298161289225813,6819]
["High","O43809","Cleavage and polyadenylation specificity factor subunit 5 [OS=Homo sapiens]",65,13,76,13,227,26.2,8.82,166.08,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT21","ENSG00000167005","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",3786.5,4072.3,4073.8,3657.9,4132.9,3847,1.0253312481740535,0.03609006865269451,0.5897650153981777,0.2293209931781738,0.7712083805441251,0.11282825970131831,5971]
["High","O43813","LanC-like protein 1 [OS=Homo sapiens]",22,7,17,7,399,45.3,7.75,32.8,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LANCL1","ENSG00000115365","","","Glutathione metabolism; Metabolic pathways",754.1,717.6,753.3,678.4,721.1,760.4,1.0301402842724199,0.04284081667351536,0.4598070072537936,0.33742441456202654,0.6743375493308829,0.17112265670602866,5324]
["High","O43815","striatin [OS=Homo sapiens]",33,19,37,19,780,86.1,5.27,61.18,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STRN","ENSG00000115808","","PIP3 activates AKT signaling; Extra-nuclear estrogen signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins","",1508.7,1548.4,1498.6,1679.3,1549.4,1603.6,0.9427601763135569,-0.08503727674093066,0.08574692517794817,1.066781444488603,0.25780207616073136,0.5887135894592703,2597]
["High","O43818","U3 small nucleolar RNA-interacting protein 2 [OS=Homo sapiens]",28,11,31,11,475,51.8,7.85,70.76,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RRP9","ENSG00000114767","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1718.6,1624.5,1805.5,1594.1,1833.6,1732.1,{"$f":"AVERAGE(T450:V450)/AVERAGE(W450:Y450)","v":0.9978293732315208},{"$f":"LOG(Z450,2)","v":-0.003134956116569531},{"$f":"TTEST(T450:V450,W450:Y450,2,2)","v":0.9677849195704195},{"$f":"-LOG10(AB450)","v":0.014221149533014428},{"$f":"AB450*7808/AF450","v":0.9814865114957573},{"$f":"-LOG10(AD450)","v":0.008115664503317318},7699]
["High","O43819","Protein SCO2 homolog, mitochondrial [OS=Homo sapiens]",30,5,9,5,266,29.8,8.85,18.75,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO2","ENSG00000284194","","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Central carbon metabolism in cancer",176,188,177.7,156.1,173.1,160.3,1.1066394279877427,0.14618523097999547,0.05166070959374272,1.2868396328020673,0.19198801547260502,0.7167258805493845,2101]
["High","O43822","Protein C21orf2 [OS=Homo sapiens]",7,2,2,2,256,28.3,7.34,2.19,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","","CFAP410","ENSG00000160226","Ciliopathies","","",52.2,55.3,51.5,58.4,55.4,41.4,1.0244845360824744,0.03489820798459022,0.8250259920707511,0.08353236898330696,0.9147689500267573,0.038688585058836975,7042]
["High","O43823","A-kinase anchor protein 8 [OS=Homo sapiens]",39,16,37,16,692,76.1,5.15,103.33,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","mitochondrion;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","AKAP8","ENSG00000105127","G protein signaling pathways","","",1345.5,1295.6,1324.5,1584.8,1430.7,1430.2,0.8920080077378141,-0.16487143331602291,0.040164798061061185,1.3961544122232277,0.16833426906106586,0.7738274624608349,1863]
["High","O43824","Putative GTP-binding protein 6 [OS=Homo sapiens]",8,4,6,4,516,56.8,9.42,7.75,"","","","","","","","",205.5,223.4,214.8,183.3,174.6,215.9,1.1218194492854656,0.1658405007410467,0.16161776655426732,0.791510899178005,0.3715876093214721,0.4299387760912846,3396]
["High","O43829","Zinc finger and BTB domain-containing protein 14 [OS=Homo sapiens]",15,3,3,3,449,50.9,6.04,3.57,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB14","ENSG00000198081","","","",20.3,23.5,21.7,21.6,26.1,26.2,0.8863328822733422,-0.17407945772133862,0.19028676637616357,0.7205914139707448,0.4063892428515003,0.3910577963739032,3656]
["High","O43837-1","isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [OS=Homo sapiens]",17,5,13,5,385,42.2,8.46,27.69,"other metabolic processes","mitochondrion","other molecular function","IDH3B","ENSG00000101365","TCA cycle (aka Krebs or citric acid cycle)","Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids",345.4,285.5,346.9,324.4,294.1,319.8,1.0420974102099543,0.05949014005254999,0.5868197453271573,0.23149528143005788,0.7694187357706875,0.11383724259021878,5955]
["High","O43847-1","Nardilysin [OS=Homo sapiens]",36,39,93,39,1150,131.5,5,209.19,"","","","","","","","",4013.4,3944.2,4159.2,3793.3,3967,3930.7,1.036421178684458,0.05161040159442057,0.16064146969578452,0.794142331191888,0.3706526582106045,0.43103288090023856,3384]
["High","O43852","Calumenin [OS=Homo sapiens]",73,26,176,7,315,37.1,4.64,391.11,"","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","CALU","ENSG00000128595","NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling pathway","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",7923.5,8714.5,8045.8,10551.8,8076.1,7597.3,0.9412244711193812,-0.08738926486528249,0.6165948642353352,0.2100000969360483,0.788336777460209,0.10328821227327854,6107]
["High","O43852-4","Isoform 4 of Calumenin [OS=Homo sapiens]",63,21,133,2,323,38.1,4.58,265.73,"","","","CALU","","","","",325.1,442.3,405.4,547.2,412.9,369.4,0.882136141406544,-0.1809267686112179,0.4584105411568853,0.3387454043180823,0.6740620537387872,0.171300120740916,5310]
["High","O43861-1","Probable phospholipid-transporting ATPase IIB [OS=Homo sapiens]",2,2,2,2,1147,129.2,7.61,2.23,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP9B","ENSG00000166377","","Ion transport by P-type ATPases","",82.6,94.9,101.9,96,92.7,93.8,0.9890265486725662,-0.0159188467804495,0.8655126877688719,0.06272656130953404,0.9328993741164208,0.030165198292919426,7244]
["High","O43865","S-adenosylhomocysteine hydrolase-like protein 1 [OS=Homo sapiens]",45,23,64,12,530,58.9,6.89,117.82,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","AHCYL1","ENSG00000168710","Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways","Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation","Cysteine and methionine metabolism; Metabolic pathways",2163.9,2264.6,2269.3,1993.9,2040.8,2104.2,1.091042369154083,0.12570712785913565,0.01655150057102072,1.781162626651297,0.10584284722238313,0.9753384859375439,1221]
["High","O43896","Kinesin-like protein KIF1C [OS=Homo sapiens]",8,8,13,3,1103,122.9,6.9,28.39,"transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1C","ENSG00000129250","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",79,79.2,82.3,81.3,81.6,97.8,0.9225163022631379,-0.11635368887815184,0.2921182578073,0.5344412981542773,0.5250597046407455,0.2797913100764325,4344]
["High","O43909","exostosin-like 3 [OS=Homo sapiens]",9,8,9,8,919,104.7,6.51,23.42,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","EXTL3","ENSG00000012232","Proteoglycan biosynthesis","XBP1(S) activates chaperone genes","Glycosaminoglycan biosynthesis; Metabolic pathways",496.6,506.6,539.5,497.7,551.4,500,0.9958685688464269,-0.005972741735859147,0.9267491781541332,0.03303779043277499,0.9640364485781338,0.01590654585120316,7506]
["High","O43913","Origin recognition complex subunit 5 [OS=Homo sapiens]",12,7,17,7,435,50.3,7.74,26.53,"DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC5","ENSG00000164815","Cell cycle; G1 to S cell cycle control; DNA replication","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle",1207.7,1180.5,1288.8,1236.4,1337.1,1322,0.9439096393274291,-0.08327933819626725,0.1822383463632916,0.7393602340494122,0.3961350246115202,0.40215675738604356,3592]
["High","O43924","Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [OS=Homo sapiens]",29,3,5,3,150,17.4,5.67,9.61,"other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PDE6D","ENSG00000156973","Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies","ARL13B-mediated ciliary trafficking of INPP5E; RAS processing","Purine metabolism; Metabolic pathways",164.7,182.4,180.7,132.5,183.4,157.9,1.1139721401435205,0.15571315208603723,0.3165361493216475,0.49957668515872367,0.5492253897563164,0.2602493942754319,4500]
["High","O43929","origin recognition complex subunit 4 [OS=Homo sapiens]",22,8,13,8,436,50.3,8,29.82,"DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC4","ENSG00000115947","Cell cycle; G1 to S cell cycle control; DNA replication","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle",499.9,521.4,567.9,508.4,598.9,555.5,0.9557373105605003,-0.06531395453627376,0.4978810912592473,0.3028743672326854,0.7043768002450087,0.15219495663931354,5519]
["High","O43933","Peroxisome biogenesis factor 1 [OS=Homo sapiens]",7,10,13,10,1283,142.8,6.33,32.41,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","PEX1","ENSG00000127980","","Peroxisomal protein import","Peroxisome",600.9,560.8,592,566.5,598.5,566,1.013113807047949,0.01879624683535857,0.6653099417836043,0.1769759868057171,0.8201357791989867,0.08611424118297485,6334]
["High","O60216","Double-strand-break repair protein rad21 homolog [OS=Homo sapiens]",50,23,72,23,631,71.6,4.65,170.12,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RAD21","ENSG00000164754","Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin","Cell cycle",1719.1,1523.6,1677.5,1829.1,1786.6,1720.3,0.9220764617691154,-0.11704170601007172,0.10875234683722114,0.9635613623507246,0.29659040311038165,0.5278429057136879,2863]
["High","O60231","Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [OS=Homo sapiens]",23,22,50,22,1041,119.2,6.8,112.69,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DHX16","ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",1940.4,1951.2,1915.8,2100.8,1996.7,2018.3,0.9495732365348769,-0.07464882130448097,0.03702157193723766,1.4315451450327468,0.16041311525302535,0.7947601270171555,1802]
["High","O60232","Sjoegren syndrome/scleroderma autoantigen 1 [OS=Homo sapiens]",19,2,2,2,199,21.5,5.24,7.53,"cell cycle OR cell proliferation;other biological processes","","","ZNRD2","ENSG00000173465","","","",94,92.5,66.2,109.5,73.5,69,1.0027777777777778,0.004001930557496263,0.9888369713277844,0.004875304246079693,0.9929062592756353,0.003091751505662489,7776]
["High","O60244","Mediator of RNA polymerase II transcription subunit 14 [OS=Homo sapiens]",5,6,8,6,1454,160.5,8.73,11.51,"other biological processes","nucleus","other molecular function","MED14","ENSG00000180182","Vitamin D in inflammatory diseases","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",243.1,254.8,293.1,279.2,301.5,308.1,0.8899639963996399,-0.168181122028938,0.13508085430637826,0.8694062013726293,0.33589532179114695,0.4737960447872088,3140]
["High","O60256-1","Phosphoribosyl pyrophosphate synthase-associated protein 2 [OS=Homo sapiens]",37,11,32,10,369,40.9,7.44,86.18,"other metabolic processes;other biological processes","other cell component","enzyme regulator activity;other molecular function","PRPSAP2","ENSG00000141127","","","",982.5,908.2,954.4,933.7,1001.1,895.3,1.0053001660718701,7.6263307040835854E-3,0.9010320263758197,0.0452597721384713,0.9498120780265155,0.022362312131430626,7407]
["High","O60264","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 [OS=Homo sapiens]",51,55,207,40,1052,121.8,8.09,440.83,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCA5","ENSG00000153147","","Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression","",8920.1,9412.5,9392.1,9522.2,9921.9,9937.6,0.9436043523689915,-0.08374602187306551,0.058623015365072265,1.2319318467175815,0.20562825874684829,0.6869172020576355,2226]
["High","O60268-1","Uncharacterized protein KIAA0513 [OS=Homo sapiens]",6,2,2,2,411,46.6,5.06,5.53,"","other cell component","","KIAA0513","ENSG00000135709","","","",170.1,205.3,175,142.8,130.2,152.6,1.2932330827067668,0.3709823192009083,0.031189231952431177,1.5059953197900815,0.14495566850272776,0.838764796857309,1680]
["High","O60271-2","Isoform 2 of C-Jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",27,31,84,27,1311,145,5.19,198.73,"","","","SPAG9","","","","",4142,3873.7,4183.1,3546.6,3551.8,3381.1,1.1640631709528126,0.21916935201546434,0.006909704797089963,2.1605405065669707,0.06579387201912003,1.1818145542920522,820]
["High","O60281-1","zinc finger protein 292 [OS=Homo sapiens]",7,12,13,12,2723,304.6,7.39,11.68,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF292","ENSG00000188994","","","",191.5,218.2,192.2,204.6,200.9,200.2,0.9937262671289416,-0.009079594651301027,0.8936006128735681,0.04885654203264718,0.9464505677315274,0.023902063921047968,7372]
["High","O60282-1","kinesin heavy chain isoform 5C [OS=Homo sapiens]",46,39,132,24,957,109.4,6.19,281.38,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF5C","ENSG00000168280; ENSPPAG00000031052; ENSPTRG00000012521","Alzheimer's disease and miRNA effects; Alzheimer's disease","Insulin processing","Endocytosis; Dopaminergic synapse; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Salmonella infection; Non-small cell lung cancer",3617.2,3648,3489,3605.2,3293.6,3436.1,1.0405712682270754,0.05737577794850525,0.24392784890589628,0.6127386140539688,0.4742501604226191,0.32399251353229624,4016]
["High","O60287","nucleolar pre-ribosomal-associated protein 1 [OS=Homo sapiens]",15,23,35,23,2271,254.2,6.47,67.46,"RNA metabolism OR transcription;other metabolic processes","nucleus","","URB1","ENSG00000142207","","","",1030.8,1057.6,1041.4,944,960.7,974.5,1.0870380661294805,0.12040246185064465,2.0801692482152446E-3,2.6819013282220237,0.03794850815435661,1.4208052925765602,428]
["Low","O60290-1","Zinc finger protein 862 [OS=Homo sapiens]",1,1,2,1,1169,131.6,7.23,0,"other biological processes","nucleus","other molecular function","ZNF862","ENSG00000106479","","","",16.8,9.2,16.7,12.9,11.6,16.5,1.0414634146341464,0.058612160115044394,0.8552131002343643,0.067925655184778,0.9301440154102126,0.03144980385924236,7179]
["High","O60291-1","E3 ubiquitin-protein ligase MGRN1 [OS=Homo sapiens]",22,7,9,7,552,60.7,5.15,21.71,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGRN1","ENSG00000102858","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis; Hedgehog signaling pathway",184.1,199.9,208.3,166.8,210.7,213.2,1.0027086507533434,3.9024741722885484E-3,0.9759865329358728,0.010556174866083687,0.986600576018034,0.005858635314805406,7724]
["High","O60293","Zinc finger C3H1 domain-containing protein [OS=Homo sapiens]",11,16,21,16,1989,226.2,8.13,32.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","ZFC3H1","ENSG00000133858","","","",537.5,525.7,496.3,687.2,655.2,659.3,0.7790877753909178,-0.3601422171942506,7.4335790580062075E-4,3.1288020353792607,0.024285098445570072,1.614660131668763,239]
["High","O60294","tRNA wybutosine-synthesizing protein 4 [OS=Homo sapiens]",3,2,3,2,686,75.6,6.73,3.23,"RNA metabolism OR transcription;other metabolic processes","other cell component","other molecular function","LCMT2","ENSG00000168806","","Synthesis of wybutosine at G37 of tRNA(Phe)","",80.2,86.9,82.4,77.9,90.5,80.4,1.0028135048231512,4.0533300940205005E-3,0.9595799952018296,0.017918814543324776,0.9782478917007292,0.00955107940860213,7659]
["High","O60299-1","Leucine zipper putative tumor suppressor 3 [OS=Homo sapiens]",4,2,2,2,673,71.7,7.64,6.26,"other biological processes","cytoskeleton;other cell component","","LZTS3","ENSG00000088899; ENSGGOG00000008647; ENSPTRG00000013192","","","",29.2,33.6,27.6,28,22.7,22.6,1.2332878581173259,0.30250957428137565,0.08732371331623891,1.0588678048174183,0.26043680426783555,0.5842976423735198,2618]
["High","O60306","Intron-binding protein aquarius [OS=Homo sapiens]",15,18,39,17,1485,171.2,6.37,84.98,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","AQR","ENSG00000021776","","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","Spliceosome",1548.8,1408.9,1657.6,1522.1,1745.8,1568.6,0.9542644474309934,-0.06753897107894694,0.4982930354708242,0.3025151828223757,0.7044490351179061,0.1521504213874174,5523]
["High","O60307","Microtubule-associated serine/threonine-protein kinase 3 [OS=Homo sapiens]",4,5,9,3,1309,143,8.06,4.49,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","","kinase activity;other molecular function","MAST3","ENSG00000099308","","","",294.3,265.1,258,343.5,317.8,310.8,0.8408599938277956,-0.250062488253685,0.02583178434683757,1.5878455936245812,0.13029365127913936,0.8850767453128197,1548]
["High","O60313-2","Isoform 2 of Dynamin-like 120 kDa protein, mitochondrial [OS=Homo sapiens]",36,30,78,30,997,115.8,7.87,168.46,"","","","OPA1","","","","",3543.5,3474.6,3693.3,3953.8,4293.4,4203.4,0.8603119528376144,-0.21706821273959798,0.008543053053148267,2.068386896619831,0.07370625219776981,1.132495671166399,905]
["High","O60318","Germinal-center associated nuclear protein [OS=Homo sapiens]",13,16,20,16,1980,218.3,6.39,57.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3AP","ENSG00000160294","","","",808.4,778.3,852,831,810.1,877.9,0.9681222707423581,-0.046738828116999094,0.4129061767329664,0.384148620392483,0.6382837909188284,0.1949861842461971,5051]
["High","O60331","Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [OS=Homo sapiens]",6,4,4,4,668,73.2,5.29,9.33,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIP5K1C","ENSG00000186111","B cell receptor signaling pathway; Focal adhesion; Regulation of actin cytoskeleton","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer",236.9,208,228.2,185.1,183.5,192.6,1.1993941553813254,0.26230584771546556,0.01436705487191392,1.842632249539051,0.09805766122369221,1.008518469337421,1144]
["High","O60333","Kinesin-like protein KIF1B [OS=Homo sapiens]",14,21,40,2,1816,204.3,5.6,93.91,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1B","ENSG00000054523","Intracellular trafficking proteins involved in CMT neuropathy","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",562.6,593.6,617.1,618.4,614.4,596.1,0.9695992126414785,-0.04453956760980658,0.3421586298970268,0.4657725017895673,0.5746557501045354,0.240592243314019,4649]
["High","O60333-3","Isoform 3 of Kinesin-like protein KIF1B [OS=Homo sapiens]",21,19,33,4,1153,130.3,8.43,68.92,"","","","KIF1B","","","","",192.2,180.9,218.9,263.3,233.3,229.8,0.8149779735682819,-0.2951670267746029,0.04446745044919681,1.3519577702044705,0.17850995018371654,0.7483375712075616,1945]
["High","O60337","E3 ubiquitin-protein ligase MARCH6 [OS=Homo sapiens]",2,2,2,2,910,102.5,6.28,2.75,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","MARCHF6","ENSG00000145495","","ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",137.3,135.3,128.7,146.6,134,151.4,0.9289351851851853,-0.10635015627083548,0.15258292696868958,0.81649405837394,0.3602562726856753,0.4433884486290074,3307]
["High","O60341","Lysine-specific histone demethylase 1A [OS=Homo sapiens]",59,30,92,30,852,92.8,6.52,245.15,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM1A","ENSG00000004487","Androgen receptor signaling pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects","Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Thermogenesis",3299.2,3405.1,3347,3322.6,3201.8,3453.3,1.0073764494823454,0.01060290907659797,0.7711280247685091,0.1128735132139119,0.8837468981935299,0.05367209749467409,6813]
["High","O60343-1","TBC1 domain family member 4 [OS=Homo sapiens]",13,14,26,14,1298,146.5,7.01,51.72,"transport;other biological processes","cytosol;other cell component","enzyme regulator activity","TBC1D4","ENSG00000136111","Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane","Thyroid hormone signaling pathway; Insulin resistance; Diabetic cardiomyopathy",670,649.6,655.1,691.9,672.4,683.8,0.9641619061569259,-0.052652664618209735,0.04227160882404903,1.3739512229514252,0.1735313994207018,0.760621930894185,1902]
["High","O60344-1","Endothelin-converting enzyme 2 [OS=Homo sapiens]",5,3,8,3,883,99.7,5.1,11.83,"protein metabolism;other metabolic processes;developmental processes","plasma membrane;other membranes;ER/Golgi","other molecular function","EEF1AKMT4-ECE2","ENSG00000284917","","","",190.5,203.4,188.8,189.7,184.9,179,1.052565028901734,0.07390936771059717,0.15552614154086986,0.8081966023107632,0.36368616746065047,0.4392732167064985,3339]
["High","O60353-1","Frizzled-6 [OS=Homo sapiens]",7,4,5,4,706,79.2,7.96,6.4,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","FZD6","ENSG00000164930","Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","Class B/2 (Secretin family receptors); Ca2+ pathway; PCP/CE pathway; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",210.7,186.5,200.8,171.1,179.8,189.8,1.1059737377473644,0.1453171280034679,0.09739496479820675,1.0114634950400656,0.2787609549649554,0.5547680563658715,2728]
["High","O60427","Fatty acid desaturase 1 [OS=Homo sapiens]",4,2,4,2,444,51.9,8.87,7.33,"cell-cell signaling;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","FADS1","ENSG00000149485","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection","PPARA activates gene expression; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism",353.9,333.4,377.5,405.9,428.4,423.4,0.8466247912856804,-0.2402053599030814,0.011253749666068276,1.948702749734218,0.08648550924474517,1.063056653023483,1016]
["High","O60437","periplakin [OS=Homo sapiens]",29,51,83,51,1756,204.6,5.6,173.43,"cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PPL","ENSG00000118898","","Formation of the cornified envelope; Butyrophilin (BTN) family interactions","",4179.4,3964.7,4076.9,3553.2,3262.4,3223,1.217400832785448,0.28380425783080127,3.8754500718515806E-3,2.4116778538360806,0.049202462050434374,1.3080131649528621,615]
["High","O60443","Non-syndromic hearing impairment protein 5 [OS=Homo sapiens]",9,4,7,4,496,54.5,5.17,20.01,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","transporter activity;other molecular function","GSDME","ENSG00000105928","","Regulation of TLR by endogenous ligand; Release of apoptotic factors from the mitochondria; Pyroptosis; Defective pyroptosis","",264.5,269.4,269.8,244.5,300.8,270.2,0.9855303494788475,-0.021027795035711155,0.8218411550405409,0.08521211452281884,0.9143539097401744,0.03888567374357076,7018]
["High","O60447","Ecotropic viral integration site 5 protein homolog [OS=Homo sapiens]",4,3,3,3,810,92.9,6.1,9.69,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","EVI5","ENSG00000067208","","","",221.6,216.7,220.9,233.7,214.6,196.4,1.022491081123003,0.03208825903427881,0.6797570442101455,0.1676462831950497,0.8287856029345434,0.08155780178367644,6404]
["High","O60462-1","Neuropilin-2 [OS=Homo sapiens]",3,2,2,2,931,104.8,5.17,3.8,"","","","","","","","",19.3,13.4,20,23.5,21.7,17.6,0.839171974522293,-0.2529615972544124,0.2843468171294209,0.5461516287125542,0.5154817618171623,0.28778669581651894,4307]
["High","O60476","mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [OS=Homo sapiens]",11,5,7,5,641,73,7.61,10.76,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","MAN1A2","ENSG00000198162","","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum",163.7,145.1,182,155.9,164.9,170.7,0.9985757884028483,-2.0561675650380955E-3,0.9847699624236792,0.00666520677921401,0.9911167654813209,3.875177384616269E-3,7758]
["High","O60481","Zinc finger protein ZIC 3 [OS=Homo sapiens]",5,3,5,2,467,50.5,8.65,8.13,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZIC3","ENSG00000156925","Mesodermal commitment pathway","POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","Signaling pathways regulating pluripotency of stem cells",393.6,392.9,402.5,359.3,358,364.6,1.0989925131712726,0.13618155803649046,6.3921223550735223E-4,3.194354920548776,0.02268622334018821,1.644237796712347,220]
["High","O60488-1","Long-chain-fatty-acid--CoA ligase 4 [OS=Homo sapiens]",30,16,48,13,711,79.1,8.38,113.55,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL4","ENSG00000068366","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway",1907.4,1871.6,2056.4,1842.1,2124.2,2078.5,0.9653586553732134,-0.05086305489303564,0.5393817968592153,0.2681037142735485,0.7362750122162156,0.13295993840793727,5720]
["Medium","O60493-1","sorting nexin-3 [OS=Homo sapiens]",9,1,1,1,162,18.8,8.66,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","LOC111158258; Snx3; SNX3; Snx3_1","ENSAMEG00000008145; ENSANAG00000028701; ENSBIXG00000016466; ENSBIXG00005007963; ENSBMUG00000010256; ENSBTAG00000018801; ENSCANG00000036155; ENSCATG00000029122; ENSCCAG00000022069; ENSCGRG00015001325; ENSCHIG00000003391; ENSCJAG00000005955; ENSCSAG00000015156; ENSDLEG00000017815; ENSFCAG00000024997; ENSG00000112335; ENSLCNG00005012116; ENSMFAG00000039300; ENSMMNG00015010894; ENSMMUG00000020366; ENSMNEG00000027766; ENSMPUG00000009812; ENSMUSG00000019804; ENSNVIG00000004406; ENSOARG00000010805; ENSPANG00000017995; ENSPCOG00000020531; ENSPCTG00005013214; ENSPPAG00000032382; ENSPPYG00000016894; ENSPTRG00000018473; ENSPTRG00000046352; ENSRFEG00010011106; ENSRROG00000037899; ENSSBOG00000028606; ENSSSCG00000004385; ENSSSCG00070023370; ENSSSUG00005019212; ENSSTOG00000007274; ENSTSYG00000035289; ENSTTRG00000008868; ENSUAMG00000027552","","Ub-specific processing proteases; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking","Endocytosis",30.6,27,30.9,38.1,27.7,19.6,1.0362997658079625,0.051441385349869306,0.8600897642992361,0.06545622072684375,0.9315551227144452,0.030791441591770892,7209]
["Medium","O60499","Syntaxin-10 [OS=Homo sapiens]",4,1,1,1,249,28.1,4.89,2.33,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","STX10","ENSG00000104915","","Retrograde transport at the Trans-Golgi-Network","Salmonella infection",63,59.7,67.6,51,50.8,63.1,1.1540327471194665,0.20668416283655497,0.14390630804516566,0.8419201686126447,0.348733846435957,0.4575059000372086,3222]
["High","O60502","protein O-GlcNAcase [OS=Homo sapiens]",30,25,64,25,916,102.8,4.91,110.82,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","OGA","ENSG00000198408","","","Insulin resistance",2686.3,2412.4,2509.9,2684.2,2717.5,2570.9,0.9543436269222086,-0.06741926933303388,0.25598203610671233,0.5917905108345045,0.48512323735951696,0.3141479222090038,4120]
["High","O60504-1","Vinexin [OS=Homo sapiens]",10,5,5,5,671,75.3,9.45,8.12,"cell adhesion;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","SORBS3","ENSG00000120896","","Smooth Muscle Contraction","",125.3,134.7,134.9,144.8,147.3,165.1,0.8637357830271215,-0.2113380357541298,0.04361258348008024,1.3603881862476792,0.17607396681099613,0.7543048513360266,1934]
["High","O60506","Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",57,31,235,2,623,69.6,8.59,555.55,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","SYNCRIP","ENSG00000135316","","","",9411.5,9175.2,9128.4,9705.2,9694.4,9750,0.9507883470099076,-0.07280387336347324,0.005856309620409794,2.23237597039215,0.06137726914920761,1.2119924384818073,745]
["High","O60506-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",55,29,216,1,562,62.6,7.56,498.21,"","","","SYNCRIP","","","","",109.6,108.1,108.6,124.2,127.7,113.8,0.8922614164615804,-0.16446163924950427,0.03522072687116951,1.4532016854817302,0.15669711419378435,0.8049390016249377,1755]
["High","O60507","Protein-tyrosine sulfotransferase 1 [OS=Homo sapiens]",5,2,2,2,370,42.2,9.09,2.99,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","TPST1","ENSG00000169902","","Cytosolic sulfonation of small molecules; Gamma carboxylation, hypusine formation and arylsulfatase activation; Defective F8 sulfation at Y1699","",132.2,126.5,139.5,129.4,120.1,125.9,1.0607352157698455,0.08506457088962836,0.17661440011436214,0.7529738894603395,0.3886711488424294,0.41041769596139294,3548]
["High","O60508","pre-mRNA-processing factor 17 [OS=Homo sapiens]",25,12,18,12,579,65.5,7.06,29.06,"RNA metabolism OR transcription;other metabolic processes","nucleus","","CDC40","ENSG00000168438","mRNA processing","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","Spliceosome",694.2,585.8,638.2,741.2,640,684.3,0.9286855482933914,-0.10673791024180615,0.31589749307130144,0.500453820595707,0.5489712054085737,0.260450434530097,4493]
["High","O60512","beta-1,4-galactosyltransferase 3 [OS=Homo sapiens]",5,2,4,2,393,43.9,9.25,8.84,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi","other molecular function","B4GALT3","ENSG00000158850","","N-Glycan antennae elongation; Keratan sulfate biosynthesis","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways",172.2,152.9,173.7,154.8,167.7,179.2,0.9942196531791909,-0.008363472934626448,0.925582002615422,0.03358509856884006,0.9634641083083876,0.016164459372772846,7501]
["High","O60513","Beta-1,4-galactosyltransferase 4 [OS=Homo sapiens]",6,2,2,2,344,40,9.07,5.73,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B4GALT4","ENSG00000121578","","N-Glycan antennae elongation; Keratan sulfate biosynthesis","Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways",110.3,102.1,126,100.9,115.5,106.9,1.0467058459635015,0.06585606099386439,0.5721806324794185,0.24246684654765396,0.7597936017685885,0.11930436796515703,5880]
["High","O60518","ran-binding protein 6 [OS=Homo sapiens]",4,4,30,1,1105,124.6,5.01,33.4,"transport","nucleus;other cell component","other molecular function","RANBP6","ENSG00000137040","","","",42.7,40.4,39,31.5,34,41,{"$f":"AVERAGE(T514:V514)/AVERAGE(W514:Y514)","v":1.1464788732394364},{"$f":"LOG(Z514,2)","v":0.1972097698742024},{"$f":"TTEST(T514:V514,W514:Y514,2,2)","v":0.16242978590933152},{"$f":"-LOG10(AB514)","v":0.7893343281125866},{"$f":"AB514*7808/AF514","v":0.3720304395365387},{"$f":"-LOG10(AD514)","v":0.42942152468284245},3409]
["High","O60524","nuclear export mediator factor NEMF [OS=Homo sapiens]",16,16,29,16,1076,122.9,6.35,56.39,"protein metabolism;other metabolic processes;transport","nucleus;other cell component","translation activity;nucleic acid binding activity","NEMF","ENSG00000165525","","","",1143.6,1254,1227.2,1296.5,1315.3,1244.4,0.9399927389658213,-0.08927848224438571,0.12210857200320795,0.9132538475782958,0.318338474190667,0.4971108696449905,2995]
["High","O60547-1","GDP-mannose 4,6 dehydratase [OS=Homo sapiens]",24,8,14,8,372,41.9,7.31,28.11,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","GMDS","ENSG00000112699; ENSPPAG00000026874; ENSPPYG00000016168; ENSPTRG00000017663","","GDP-fucose biosynthesis","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",1006,1022.9,1143.7,990.5,1117.4,1050.1,1.0046231792273592,0.00665446717252958,0.9358112307046957,0.028811747128653694,0.9677899456082469,0.014218894099206535,7550]
["High","O60551","Glycylpeptide N-tetradecanoyltransferase 2 [OS=Homo sapiens]",13,6,24,2,498,56.9,7.58,43.67,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NMT2","ENSG00000152465","","Membrane binding and targetting of GAG proteins; Inactivation, recovery and regulation of the phototransduction cascade","",125.8,105.9,116,116.3,107.7,115.2,1.0250589622641508,0.03570689716442861,0.6784793723781593,0.1684633515392768,0.8276155193764517,0.08217137407643182,6401]
["High","O60563","Cyclin-T1 [OS=Homo sapiens]",17,10,15,10,726,80.6,8.78,34.59,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","CCNT1","ENSG00000129315","Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins","Transcriptional misregulation in cancer",1134.3,1135.6,1052.5,1003.2,929,1013.6,1.127843030755652,0.17356629246318703,0.030507129241732593,1.5155986580781153,0.14375356977637183,0.8423813618388165,1657]
["High","O60566","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta [OS=Homo sapiens]",29,25,53,25,1050,119.5,5.27,104.76,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","BUB1B","ENSG00000156970","Regulation of sister chromatid separation at the metaphase-anaphase transition","Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Human T-cell leukemia virus 1 infection",2411.2,2390.2,2550.6,2305.4,2115.5,2134.9,1.1214497086549315,0.16536492430205457,0.027836747646044543,1.5553815076350228,0.13626916966790958,0.8656023903695874,1595]
["High","O60568","Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [OS=Homo sapiens]",29,18,53,18,738,84.7,6.05,89.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi","other molecular function","PLOD3","ENSG00000106397","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway","Collagen biosynthesis and modifying enzymes","Lysine degradation; Other types of O-glycan biosynthesis; Metabolic pathways",1657.1,1634.1,1737,1689,1710.3,1655.7,0.994698318496538,-0.007669057073591246,0.8111056834291885,0.09092255548075368,0.9069330053293863,0.04242479286313479,6983]
["High","O60573","eukaryotic translation initiation factor 4E type 2 [OS=Homo sapiens]",42,10,20,10,245,28.3,8.88,48.7,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF4E2","ENSG00000135930","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance","ISG15 antiviral mechanism","EGFR tyrosine kinase inhibitor resistance; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Longevity regulating pathway; Insulin signaling pathway",1042.4,1094.8,1104.7,1109.4,1113.3,1111.1,0.9724338592597035,-0.04032796732119266,0.18878229847233946,0.7240387305686578,0.40417115066411474,0.3934346892238037,3647]
["High","O60583-2","Isoform 2 of Cyclin-T2 [OS=Homo sapiens]",16,9,15,9,663,73.6,9.14,33.54,"","","","CCNT2","","","","",788.1,735.1,716.2,651.4,596.3,623.7,1.1966442235759327,0.25899428580126604,0.010153222702784508,1.9933960878107722,0.0817282091374654,1.0876280174183817,970]
["High","O60610-1","Protein diaphanous homolog 1 [OS=Homo sapiens]",38,45,105,44,1272,141.3,5.41,228.5,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH1","ENSG00000131504","Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway","RHOC GTPase cycle; RHOA GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility","Focal adhesion; Regulation of actin cytoskeleton; AGE-RAGE signaling pathway in diabetic complications; Shigellosis",5259,5121.5,5552,5340.7,5225.3,5411.3,0.9971960218560082,-0.004050967433055779,0.9190604064259155,0.0366559431130289,0.9584644922363494,0.01842397158243244,7487]
["High","O60613-1","selenoprotein F [OS=Homo sapiens]",15,2,6,2,162,17.8,5.03,5.79,"","","","","","","","",63.2,61.2,54.9,59,62.4,58.4,0.9972191323692993,-0.004017532646072457,0.9552918912232058,0.01986390864800959,0.9774497558210969,0.009905557543825437,7631]
["High","O60636","tetraspanin-2 [OS=Homo sapiens]",5,1,1,1,221,24.1,7.77,0,"cell organization and biogenesis;stress response;developmental processes","plasma membrane;other membranes;nucleus;other cell component","","TSPAN2","ENSG00000134198","","","",18,15.1,19,24.7,18,24.5,0.775297619047619,-0.36717786050025225,0.11354606252048903,0.9448279213762009,0.30476715577861063,0.5160318379646247,2909]
["High","O60637","Tetraspanin-3 [OS=Homo sapiens]",12,4,5,4,253,28,5.81,9.62,"","plasma membrane;other membranes","","TSPAN3","ENSG00000140391","","","",241.1,227.9,236.3,170.1,154.5,174.9,1.4120120120120119,0.49775236169439674,7.0196695042730722E-4,3.153683334572374,0.023323225314623042,1.6322113921854748,235]
["High","O60645","exocyst complex component 3 [OS=Homo sapiens]",17,12,20,12,756,86.8,6.11,44.52,"","","","","","","","",795.2,816.6,801.7,820.4,829.9,838.2,0.9698613622664256,-0.04414956023241686,0.03750588644681493,1.4259005655857424,0.16197232377031578,0.7905591870664516,1808]
["High","O60664-1","Perilipin-3 [OS=Homo sapiens]",59,23,111,23,434,47,5.44,261.52,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","PLIN3","ENSG00000105355","","Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle; Lipophagy; Chaperone Mediated Autophagy","",4228.1,4227.4,4100.3,4218.7,3908.9,4018,1.033773547622184,0.047920191936655296,0.244022261654477,0.6125705520519148,0.47431561339262046,0.32393257912495077,4017]
["High","O60671-1","Cell cycle checkpoint protein RAD1 [OS=Homo sapiens]",14,2,4,2,282,31.8,4.83,6.33,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD1","ENSCCAG00000029737; ENSG00000113456; ENSGGOG00000004219; ENSMFAG00000012657; ENSMMUG00000045918; ENSPANG00000024799; ENSPPAG00000028406; ENSPPYG00000015389; ENSPTRG00000016783","miRNA regulation of DNA damage response; ATR signaling; DNA damage response","Presynaptic phase of homologous DNA pairing and strand exchange; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","Cellular senescence",70.9,47.2,46.5,54,56.3,49.3,1.0313283208020052,0.044503684199280164,0.8502868932212644,0.07043451532019415,0.9272402321608425,0.032807732969414305,7160]
["High","O60674","Tyrosine-protein kinase JAK2 [OS=Homo sapiens]",1,1,2,1,1132,130.6,7.21,2.52,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK2","ENSG00000096968","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Mesodermal commitment pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; IL-6 signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; Overview of interferons-mediated signaling pathway; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 distal deletion syndrome; CCL18 signaling pathway; EPO receptor signaling; Notch signaling pathway; Type II interferon signaling (IFNG); Serotonin receptor 2 and STAT3 signaling","Potential therapeutics for SARS; Signaling by BRAF and RAF1 fusions; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Signaling by SCF-KIT; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Interleukin-4 and Interleukin-13 signaling; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; RMTs methylate histone arginines; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; RAF activation; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; IL-6-type cytokine receptor ligand interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; PI3K-Akt signaling pathway; Necroptosis; Signaling pathways regulating pluripotency of stem cells; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Cholinergic synapse; Prolactin signaling pathway; Adipocytokine signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis B; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",19.2,21.7,23.8,27.6,30.6,25.2,0.7757793764988009,-0.3662816714521562,0.03844955297856076,1.4151087050191924,0.1640514260418592,0.7850199900909867,1830]
["High","O60678","protein arginine N-methyltransferase 3 [OS=Homo sapiens]",18,8,22,8,531,59.8,5.35,43.19,"","","","","","","","",704.8,673.8,753.4,737.2,737.3,734.9,0.9649678645786185,-0.051447196428949044,0.32803980531231114,0.4840734545242865,0.5600994532863602,0.251734851246333,4573]
["High","O60684","Importin subunit alpha-7 [OS=Homo sapiens]",44,20,107,12,536,60,4.98,265.21,"transport;other biological processes","nucleus;other cell component","other molecular function","KPNA6","ENSG00000025800","","Assembly of the ORC complex at the origin of replication","Nucleocytoplasmic transport; Influenza A; Chemical carcinogenesis",4839.1,4904.8,4984.9,4905,5048.5,4890.7,0.9922259198879024,-0.011259449685288258,0.5896373970479918,0.22941497966642713,0.7711706526215611,0.11284950613716078,5970]
["High","O60701","UDP-glucose 6-dehydrogenase [OS=Homo sapiens]",53,21,75,21,494,55,7.12,177.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus","other molecular function","UGDH","ENSG00000109814","Glucuronidation","Formation of the active cofactor, UDP-glucuronate","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",3192.6,3113.8,3344.7,3076.6,3284.9,3283.3,1.000653201725282,9.4206324458128842E-4,0.9837362683092258,0.007121316781953812,0.9907149210574533,4.0512960928258054E-3,7753]
["High","O60716-1","Catenin delta-1 [OS=Homo sapiens]",46,35,142,35,968,108.1,6.23,291.16,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","CTNND1","ENSG00000198561","VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency","VEGFR2 mediated vascular permeability; Adherens junctions interactions; InlA-mediated entry of Listeria monocytogenes into host cells","Rap1 signaling pathway; Adherens junction; Leukocyte transendothelial migration",6009.9,5617.9,5877.5,6556.4,6110.7,6218.4,0.9269174763707605,-0.10948719371758156,0.05997268898524223,1.222046478337946,0.20830371690247837,0.6813029805763341,2248]
["High","O60725","protein-s-isoprenylcysteine O-methyltransferase [OS=Homo sapiens]",6,2,3,2,284,31.9,7.96,5.94,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ICMT","ENSG00000116237","Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome","RAS processing; Gamma carboxylation, hypusine formation and arylsulfatase activation","Terpenoid backbone biosynthesis",347.2,345.6,356.3,344.4,350.4,349.8,1.0043078690407812,0.006201593046615227,0.7159655819859312,0.1451078546654168,0.8523035926431088,0.06940568090881648,6559]
["Medium","O60729-1","Dual specificity protein phosphatase CDC14B [OS=Homo sapiens]",2,1,1,1,498,56.8,9.03,1.72,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CDC14B","ENSG00000081377; ENSPPYG00000019417; ENSPTRG00000021155","Cell cycle; Cell cycle","MAPK6/MAPK4 signaling","Cell cycle",56.4,59.8,67.1,82.5,87.8,66.2,0.7750528541226216,-0.36763339768687175,0.07011616369160711,1.1541818537468667,0.22782646945654114,0.6423958198921313,2403]
["High","O60749","Sorting nexin-2 [OS=Homo sapiens]",30,15,58,13,519,58.4,5.12,116.69,"cell organization and biogenesis;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX2","ENSG00000205302","","Golgi Associated Vesicle Biogenesis","Endocytosis",2810.8,2772.6,2900.9,2761.6,2871.4,2864.9,0.9983996046081973,-2.3107320312574244E-3,0.9348089823546406,0.02927712322855587,0.9671377413839981,0.01451166856131856,7547]
["High","O60762","Dolichol-phosphate mannosyltransferase subunit 1 [OS=Homo sapiens]",30,6,23,6,260,29.6,9.57,40.23,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DPM1","ENSG00000000419","VEGFA-VEGFR2 signaling pathway","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","N-Glycan biosynthesis; Metabolic pathways",856.6,946.1,869.9,879.8,909.8,925.2,0.9844555768380727,-0.022601988325173506,0.6726036067140011,0.17224080819029672,0.8249589948512285,0.08356763781664564,6366]
["High","O60763-1","General vesicular transport factor p115 [OS=Homo sapiens]",42,38,134,38,962,107.8,4.91,304.95,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","USO1","ENSG00000138768","","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization","",5603.9,5688.1,5751.9,6021.5,6021.1,5974.7,0.9459741470697608,-0.08012733881096766,2.0594241578180974E-3,2.686254197127125,0.037658041742959496,1.4241422674935138,427]
["High","O60784","Target of Myb protein 1 [OS=Homo sapiens]",25,10,19,10,492,53.8,4.7,26.27,"transport;signal transduction","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","TOM1","ENSG00000100284","","Neutrophil degranulation","",421.9,372.8,401.7,426.8,337.5,362.5,1.0617678381256657,0.0864683467444215,0.4848458018056631,0.314396360516915,0.6950020232235391,0.15801393113141168,5447]
["High","O60825-1","6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",41,17,41,1,505,58.4,8.38,68.77,"other metabolic processes;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PFKFB2","ENSG00000123836; ENSGGOG00000012227; ENSPPAG00000041619; ENSPTRG00000001925","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects","Regulation of glycolysis by fructose 2,6-bisphosphate metabolism","Fructose and mannose metabolism; Metabolic pathways; AMPK signaling pathway; Thyroid hormone signaling pathway",1416.4,1246.8,1311.8,1165.5,1261,1257.1,1.079107394939733,0.10983845188509152,0.17177825688989456,0.765031808550987,0.38464141949994174,0.41494395126832806,3487]
["High","O60825-2","Isoform 2 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",45,17,40,1,471,54.4,7.56,67.1,"","","","PFKFB2","","","","",57.5,64.3,63.8,48.7,51.2,44.8,1.2826537664132691,0.3591317885958478,0.00900450590976653,2.045540112555611,0.0758437779325319,1.120080042041473,927]
["High","O60826","Coiled-coil domain-containing protein 22 [OS=Homo sapiens]",16,8,11,8,627,70.7,6.74,31.95,"transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","CCDC22","ENSG00000101997","","Neddylation","",540.1,495.5,549.8,599.8,537.1,562.6,0.9328626066490142,-0.10026348037219651,0.1987010634228804,0.701799808595001,0.41829547134156114,0.3785168372649757,3709]
["High","O60828","Polyglutamine-binding protein 1 [OS=Homo sapiens]",42,9,24,9,265,30.5,6.33,63.4,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PQBP1","ENSG00000102103","","mRNA Splicing - Major Pathway","Spliceosome",1116.6,1132.7,1033.4,1277.1,982.8,902.9,1.0379094473251549,0.053680580888830334,0.7515997127032082,0.12401339457927567,0.8745887566000968,0.058196110089632366,6710]
["High","O60830-1","Mitochondrial import inner membrane translocase subunit Tim17-B [OS=Homo sapiens]",33,4,14,4,172,18.3,9.03,34.75,"cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity","TIMM17B","ENSG00000126768; ENSGGOG00000011427; ENSNLEG00000007902; ENSPPAG00000036547; ENSPPYG00000020323; ENSPTRG00000021872","","Mitochondrial protein import","",441.4,448.6,454,459.2,464.2,464.2,0.9685788411646008,-0.04605860762025958,0.022311986894343216,1.6514617538386405,0.12114881340127388,0.9166808352268688,1438]
["High","O60831","PRA1 family protein 2 [OS=Homo sapiens]",16,3,6,3,178,19.2,9.19,8.51,"transport","other membranes;other cytoplasmic organelle","","PRAF2","ENSG00000243279","","","",295.6,332.3,312.4,287.7,253.4,299.5,1.1186057577920534,0.16170166142993023,0.12917780177526358,0.88881211013964,0.3274741156692396,0.4848230219814489,3080]
["High","O60832-1","H/ACA ribonucleoprotein complex subunit 4 [OS=Homo sapiens]",45,21,88,21,514,57.6,9.42,241.12,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DKC1","ENSG00000130826; ENSGGOG00000001045; ENSPTRG00000022449","","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","Ribosome biogenesis in eukaryotes",3908.4,3927.2,4167.1,4060.1,4297.8,4232.3,0.9533367222125144,-0.0689422252799052,0.14782815248660738,0.8302428507496962,0.35406202902313816,0.4509206461589998,3260]
["High","O60841","Eukaryotic translation initiation factor 5B [OS=Homo sapiens]",39,50,196,49,1220,138.7,5.49,410.84,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","EIF5B","ENSG00000158417","Translation factors; Ciliary landscape","GTP hydrolysis and joining of the 60S ribosomal subunit","",9147.9,9112.4,9304.4,9088.2,8914,9221.6,1.0125221313703447,0.017953442287926263,0.3473682623348978,0.4592098638465334,0.5799126346612962,0.2366374290964021,4677]
["High","O60858","E3 ubiquitin-protein ligase TRIM13 [OS=Homo sapiens]",15,5,5,5,407,47,6.01,7.74,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","TRIM13","ENSG00000204977","","ER Quality Control Compartment (ERQC)","",67.6,69.1,65.8,65.2,58.5,61.8,1.091644204851752,0.12650272115118386,0.05833636997391461,1.2340605986861153,0.20517584538573208,0.6878737684781185,2220]
["High","O60870","DNA/RNA-binding protein KIN17 [OS=Homo sapiens]",33,13,23,12,393,45.3,8.95,49.7,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","KIN","ENSG00000151657","","Protein methylation","",969.2,1008.1,987.9,1150.4,1039.2,1125.1,0.8945605937188886,-0.1607488872921097,0.030391815751240094,1.5172433523324582,0.14355674372999555,0.8429764012452702,1653]
["High","O60879","Protein diaphanous homolog 2 [OS=Homo sapiens]",11,11,15,11,1101,125.5,6.58,30.96,"cell organization and biogenesis;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH2","ENSG00000147202","","RHOF GTPase cycle","Regulation of actin cytoskeleton",671.5,640.3,701.7,807.1,752.3,750,0.8718714817701566,-0.19781260469887868,0.018583423263549115,1.7308742813258156,0.11239300452501277,0.9492607189336005,1291]
["High","O60884","DnaJ homolog subfamily A member 2 [OS=Homo sapiens]",49,18,78,18,412,45.7,6.48,164.08,"stress response;other biological processes","other membranes;cytosol","other molecular function","DNAJA2","ENSG00000069345","","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","Protein processing in endoplasmic reticulum",3402.2,3570.3,3598.9,3983.3,3820.9,3987.9,0.8964815427277583,-0.15765421451456893,0.007808695091049161,2.107421534894258,0.07024227104943762,1.153401455412115,868]
["High","O60885-1","Bromodomain-containing protein 4 [OS=Homo sapiens]",12,13,29,10,1362,152.1,9.19,40.31,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD4","ENSG00000141867; ENSPTRG00000010619","VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome","Potential therapeutics for SARS","",790.9,733.5,774.5,2378.7,2148.6,2261.3,0.3386412515098843,-1.5621703693685471,2.6101974707199653E-5,4.583326635497008,0.0065743296294779,2.1821485246726455,31]
["High","O60888-1","Protein CutA [OS=Homo sapiens]",25,3,30,3,179,19.1,5.5,46.54,"other biological processes","other membranes","other molecular function","CUTA","ENSG00000112514; ENSG00000226492","","","",705.1,761.5,634.8,643.8,637.9,642.1,1.092317288699449,0.1273919811155073,0.18193299875001118,0.7400885220729824,0.39613297664252295,0.402159002640511,3586]
["High","O60890","Oligophrenin-1 [OS=Homo sapiens]",3,2,3,2,802,91.6,7.96,6.85,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","OPHN1","ENSG00000079482","","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle","",36.8,39.8,33.7,41.7,38.7,43.4,0.8909531502423261,-0.1665785236228824,0.11418522954711484,0.9423900707053584,0.3058518944438671,0.514488825141756,2915]
["High","O60906","Sphingomyelin phosphodiesterase 2 [OS=Homo sapiens]",6,2,2,2,423,47.6,6.98,3.61,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SMPD2","ENSG00000135587","TNF-alpha signaling pathway; S1P receptor signal transduction","Glycosphingolipid metabolism; Ceramide signalling; TNFR1-mediated ceramide production","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",33.3,29.2,40.6,35.8,37.6,44.1,0.8774468085106384,-0.18861642408425355,0.31479479915395425,0.5019724514000036,0.5480307228080434,0.26119509412147907,4485]
["High","O60907","F-box-like/WD repeat-containing protein TBL1X [OS=Homo sapiens]",10,4,9,1,577,62.5,6.55,17.27,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1X","ENSG00000101849","Ectoderm differentiation; Ectoderm differentiation; Rett syndrome causing genes","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression","Wnt signaling pathway",84.9,87.9,94.1,84.2,81.2,87.1,1.0570297029702969,0.08001591761544674,0.2079799993489441,0.6819784274893195,0.43097341690991386,0.3655495169515239,3768]
["High","O60911","Cathepsin L2 [OS=Homo sapiens]",8,3,8,2,334,37.3,8.76,14.61,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","CTSV","ENSG00000136943","Endochondral ossification; Endochondral ossification with skeletal dysplasias","MHC class II antigen presentation; Assembly of collagen fibrils and other multimeric structures; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; Trafficking and processing of endosomal TLR; Endosomal/Vacuolar pathway; Activation of Matrix Metalloproteinases","Lysosome; Apoptosis",470.9,491,492.9,395.5,399.5,444.1,1.1740779598095392,0.2315282078486472,0.013624063788708621,1.8656933316470916,0.09583485591192516,1.0184765057751135,1110]
["High","O60921","checkpoint protein HUS1 [OS=Homo sapiens]",20,4,12,4,280,31.7,6.84,21.23,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","","HUS1","ENSG00000136273","ATR signaling","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","Cellular senescence",311.6,330.5,319.1,306.5,327.1,332.1,0.9953401677539608,-0.006738429068967998,0.8830293226012245,0.05402487464160929,0.9411265289203331,0.026351984311500008,7326]
["Medium","O60925","prefoldin subunit 1 [OS=Homo sapiens]",6,1,1,1,122,14.2,6.81,2.38,"other biological processes","other cell component","other molecular function","PFDN1","ENSG00000113068","Cellular proteostasis","Prefoldin mediated transfer of substrate  to CCT/TriC","",125.8,151.8,114,173.8,121.4,110.4,0.9654832347140038,-0.05067688739964576,0.8459715128598978,0.07264426109342637,0.925636991649395,0.033559297802857595,7136]
["High","O60927","Protein phosphatase 1 regulatory subunit 11 [OS=Homo sapiens]",12,1,4,1,126,13.9,7.01,8.42,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R11","ENSG00000204619; ENSG00000206501; ENSG00000227720; ENSG00000233314; ENSG00000234058; ENSG00000236560; ENSG00000237403; ENSG00000237829","","","",105.4,93.4,100.3,117.9,90.8,106.3,0.9495238095238095,-0.07472391815528903,0.5704378583209841,0.24379165932327954,0.7588990965701559,0.11981596417821755,5869]
["High","O60930","Ribonuclease H1 [OS=Homo sapiens]",12,4,7,4,286,32,9.16,13.39,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","RNASEH1","ENSG00000171865","","","DNA replication",374,379.4,334.6,321,318.2,345.7,1.1046806782414458,0.14362940084356488,0.10726341855905829,0.9695483658879961,0.29396727697758057,0.5317010104688376,2849]
["High","O60934","Nibrin [OS=Homo sapiens]",9,4,4,4,754,84.9,6.9,2.27,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NBN","ENSG00000104320","miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks","Homologous recombination; Cellular senescence",19.4,29.3,10.4,34.2,13.3,21.3,0.8590116279069767,-0.21925043452456555,0.712705005904466,0.14709019079045832,0.851407693712067,0.069862429656182,6536]
["High","O60942-1","mRNA-capping enzyme [OS=Homo sapiens]",19,9,15,9,597,68.5,8.13,31.54,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RNGTT","ENSG00000111880; ENSGGOG00000007863; ENSNLEG00000013064; ENSPPAG00000024828; ENSPTRG00000018413","mRNA processing; Ciliary landscape; mRNA Processing","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA surveillance pathway",647.2,660.9,595,574.6,544.2,567.9,1.1282978597260922,0.17414797555910033,0.030936450444287604,1.509529517426964,0.1449021026208744,0.8389253125963338,1667]
["High","O75027-1","ATP-binding cassette sub-family B member 7, mitochondrial [OS=Homo sapiens]",22,13,31,13,752,82.6,9.33,70,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","ABCB7","ENSG00000131269","","Mitochondrial ABC transporters; Cytosolic iron-sulfur cluster assembly","ABC transporters",1845.1,1934.3,1942.5,1967.6,2065.8,2069.5,0.9375706631273657,-0.09300066678977165,0.04979132167852747,1.3028463455045554,0.1880844894368372,0.7256470174732081,2067]
["High","O75037","Kinesin-like protein KIF21B [OS=Homo sapiens]",4,6,6,4,1637,182.5,7.08,15.92,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF21B","ENSG00000116852","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",183.3,171.8,186.5,174.4,188.3,189.4,0.9809817062126427,-0.0277018622169423,0.6226670948654225,0.20574408416772996,0.7919505907654697,0.10130191288939193,6139]
["High","O75044","SLIT-ROBO Rho GTPase-activating protein 2 [OS=Homo sapiens]",28,29,63,26,1071,120.8,6.7,132.98,"","","","","","","","",2398.3,2321.2,2443.4,2382.8,2315.5,2307,1.0224972520805675,0.03209696598847636,0.28874730047129116,0.5394820673453486,0.521039732396543,0.28312915788543747,4327]
["High","O75052","Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein [OS=Homo sapiens]",18,7,19,6,506,56.1,6.3,27.08,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","NOS1AP","ENSG00000198929","Sudden infant death syndrome (SIDS) susceptibility pathways","","Circadian entrainment",251.7,292.1,251.4,239.4,258.3,227.8,1.0960716747070984,0.13234214260817923,0.2243037622034843,0.6491634420188584,0.4511498648337984,0.34567916841256713,3882]
["High","O75054","Immunoglobulin superfamily member 3 [OS=Homo sapiens]",10,10,13,10,1194,135.1,6.07,25.92,"developmental processes","other membranes","","IGSF3","ENSG00000143061","","","",520.5,532.1,532.7,586.8,569.3,551.9,0.9281615925058546,-0.10755209512517958,0.019487526047667684,1.7102432913104384,0.1159745452592906,0.9356373216914444,1312]
["High","O75063","Glycosaminoglycan xylosylkinase [OS=Homo sapiens]",20,7,19,7,409,46.4,6.87,40.25,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;nucleus","kinase activity;other molecular function","FAM20B","ENSG00000116199","","","",629.6,575,590.9,617.4,629.2,647.6,0.9478935698447893,-0.07720301348212077,0.14898226402222095,0.8268654302169378,0.35584384138436864,0.4487405461386714,3269]
["High","O75064","DENN domain-containing protein 4B [OS=Homo sapiens]",1,1,1,1,1496,163.7,7.21,2.83,"other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","DENND4B","ENSG00000198837","","RAB GEFs exchange GTP for GDP on RABs","",15.1,14.5,15.7,14.1,19.9,24.7,0.7717206132879046,-0.373849453063817,0.22109864791093098,0.6554139132630644,0.44712205203018623,0.3495739102284781,3861]
["High","O75083","WD repeat-containing protein 1 [OS=Homo sapiens]",52,22,173,22,606,66.2,6.65,467.8,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","WDR1","ENSG00000071127","Hypertrophy model","Platelet degranulation","",5920.4,6113.1,6121.6,5554.3,6032.3,5837.5,1.0419533864015933,0.059290737586198454,0.18769547385775756,0.7265461999535097,0.4029492053564397,0.3947496963495862,3637]
["Medium","O75093-1","Slit homolog 1 protein [OS=Homo sapiens]",1,1,2,1,1534,167.8,6.57,0,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","SLIT1","ENSG00000187122","Spinal cord injury","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO","Axon guidance",42.6,33.5,37.4,34.4,36.8,32.3,1.096618357487923,0.13306152979159003,0.3200850586525097,0.4947345979465099,0.5529256942386717,0.25733322809925663,4520]
["High","O75096","Low-density lipoprotein receptor-related protein 4 [OS=Homo sapiens]",6,8,12,8,1905,211.9,5.27,18.09,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LRP4","ENSG00000134569","","ECM proteoglycans","",462.4,469.8,463.4,543.6,502.2,488.9,0.9093633934971005,-0.13707116545100528,0.04942922056135935,1.3060162377805649,0.18762438217943306,0.7267107248166534,2057]
["High","O75113","NEDD4-binding protein 1 [OS=Homo sapiens]",27,15,22,15,896,100.3,5.36,44.29,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","N4BP1","ENSG00000102921","","","",510.8,461.9,513,523.6,506.1,496.5,0.9734635041278994,-0.03880120263996312,0.5053266430419273,0.29642780324395884,0.7097662221391201,0.14888467262388339,5559]
["High","O75116","Rho-associated protein kinase 2 [OS=Homo sapiens]",32,43,81,39,1388,160.8,6.02,164.08,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","ROCK2","ENSG00000134318","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; G13 signaling pathway","RHOA GTPase cycle; RHOB GTPase cycle; G alpha (12/13) signalling events; RHOC GTPase cycle; Potential therapeutics for SARS; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; Wnt signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis",3499.3,3594.9,3476.5,3749.1,3528.4,3583.2,0.9732982220298876,-0.03904617526349308,0.27023520480161256,0.5682580740588715,0.5010677936573239,0.3001035108205012,4211]
["High","O75122","CLIP-associating protein 2 [OS=Homo sapiens]",28,29,69,23,1294,141,8.47,123.98,"","","","","","","","",1730,1720.4,1765.6,2058.8,1866.5,1928.3,0.8910755774224409,-0.16638029439890015,0.021887451261840975,1.659804807978153,0.12035015454398192,0.9195533477025742,1420]
["High","O75127","pentatricopeptide repeat-containing protein 1, mitochondrial [OS=Homo sapiens]",16,10,20,10,700,78.8,8.59,39.44,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity","PTCD1","ENSG00000106246","","","",798.3,758,760.6,786.2,737.6,751.2,{"$f":"AVERAGE(T578:V578)/AVERAGE(W578:Y578)","v":1.0184175824175825},{"$f":"LOG(Z578,2)","v":0.026329231900697126},{"$f":"TTEST(T578:V578,W578:Y578,2,2)","v":0.5128401796629519},{"$f":"-LOG10(AB578)","v":0.2900179563396407},{"$f":"AB578*7808/AF578","v":0.7161967667337379},{"$f":"-LOG10(AD578)","v":0.14496764393967823},5591]
["High","O75128","Protein cordon-bleu [OS=Homo sapiens]",5,5,6,5,1261,135.5,7.75,9.69,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity","COBL","ENSG00000106078","","","",248.8,262.6,296.5,310.5,306.5,298.5,0.8824685963954123,-0.1803831554618715,0.06999474382745498,1.1549345715920207,0.22771623325198684,0.6426060086449913,2400]
["High","O75129","Astrotactin-2 [OS=Homo sapiens]",3,3,4,3,1339,148.1,5.97,2.75,"cell adhesion;transport;developmental processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","ASTN2","ENSG00000148219","","","",214.9,256.7,192.7,206.7,186.6,182.5,1.153699201111497,0.20626712551527898,0.21791160009698818,0.6617196503227262,0.4428562658920572,0.35373720618976556,3842]
["High","O75131","Copine-3 [OS=Homo sapiens]",18,7,16,7,537,60.1,5.85,30.52,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CPNE3","ENSG00000085719","","Neutrophil degranulation; Glycerophospholipid biosynthesis","",564.3,583.5,550,548.5,553.1,520.2,1.0468615119003575,0.06607060243167177,0.14771358884081473,0.8305795501374923,0.3540048194196076,0.45099082545134744,3258]
["High","O75132","Zinc finger BED domain-containing protein 4 [OS=Homo sapiens]",1,1,1,1,1171,130.2,6.83,2.39,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED4","ENSG00000100426","","","",28.2,24.8,22.6,17.4,14.9,18.5,1.4881889763779528,0.5735577374489068,0.013183854134767263,1.8799576106239102,0.09375185162501165,1.0280201460793479,1098]
["High","O75143-1","Autophagy-related protein 13 [OS=Homo sapiens]",22,7,15,7,517,56.5,5.12,28.19,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","ATG13","ENSG00000175224","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease","Macroautophagy","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",567.8,587.4,573.2,603.8,576.7,597.3,0.9722128473394082,-0.040655896092704986,0.17647195633489227,0.7533242997757275,0.38857671603576954,0.4105232263819911,3546]
["High","O75145-1","Liprin-alpha-3 [OS=Homo sapiens]",6,9,9,3,1194,133.4,5.68,19.15,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;other cell component","","PPFIA3","ENSG00000177380","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",323.6,315.2,343,382.2,373.2,331.5,0.9033029717545311,-0.14671813980839557,0.1182040915271567,0.9273674904859565,0.31222515109744237,0.5055321155501091,2956]
["High","O75146","Huntingtin-interacting protein 1-related protein [OS=Homo sapiens]",20,19,30,18,1068,119.3,6.67,74.35,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","cytoskeletal activity;other molecular function","HIP1R","ENSG00000130787","","Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",1093.2,1160.9,1138.4,1139.8,1135.1,1112.6,1.0014760147601478,0.002127869177620514,0.9422104952312083,0.02585206248834533,0.9711920193749537,0.01269489500405254,7575]
["High","O75147","Obscurin-like protein 1 [OS=Homo sapiens]",9,12,17,12,1896,206.8,5.63,32.06,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","OBSL1","ENSG00000124006","","Neddylation","",743.1,623.7,630.1,785.7,812.1,839.9,0.819173811379579,-0.2877585011275043,0.024586381660398855,1.6093053810030007,0.12713276026781076,0.8957425236375347,1510]
["High","O75150","E3 ubiquitin-protein ligase BRE1B [OS=Homo sapiens]",39,39,91,37,1001,113.6,6.23,233.37,"protein metabolism;other metabolic processes","nucleus","other molecular function","RNF40","","","","",3646.1,3354.6,3649.5,3661.4,3758,3668.7,0.9605072104328066,-0.058131650786661354,0.2277330526079053,0.6425739323910826,0.4555828016301626,0.3414326790136959,3903]
["High","O75152","Zinc finger CCCH domain-containing protein 11A [OS=Homo sapiens]",36,27,85,27,810,89.1,8.37,174.52,"other metabolic processes;transport","nucleus","nucleic acid binding activity;other molecular function","ZC3H11A","ENSG00000058673","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",4488,4361.1,4341.7,4840.2,4608.1,4605.4,0.9385997993410988,-0.09141794294823992,0.03340653896239145,1.476168516501831,0.15191511719181855,0.8183990070041122,1717]
["High","O75153","Clustered mitochondria protein homolog [OS=Homo sapiens]",31,32,66,32,1309,146.6,6.13,126.38,"cell organization and biogenesis","other cell component","nucleic acid binding activity","CLUH","ENSG00000132361","Translation factors","","",2233.2,2218.4,2262.2,2184.4,2179.1,2222,1.01948219573305,0.027836580306029066,0.08356843995723448,1.0779577050996498,0.2543868924702093,0.5945052698888496,2565]
["High","O75154","Rab11 family-interacting protein 3 [OS=Homo sapiens]",3,2,2,1,756,82.4,4.51,2.62,"cell cycle OR cell proliferation;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RAB11FIP3","ENSG00000090565; ENSG00000275338","","VxPx cargo-targeting to cilium","Endocytosis",33.3,29,35.5,29.9,32.4,27.8,1.0854605993340734,0.11830735913869529,0.33177558565576876,0.479155575530136,0.5638885008272186,0.24880676173050786,4594]
["High","O75157","TSC22 domain family protein 2 [OS=Homo sapiens]",8,6,17,5,780,79.2,5.02,28.74,"stress response;other biological processes","","","TSC22D2","ENSG00000196428","","","",792.5,798.7,783.2,765.1,632.9,689.1,1.137655119543865,0.18606327053248758,0.06799329766392637,1.1675338951030454,0.22362749290646045,0.6504748050629824,2374]
["High","O75164-1","Lysine-specific demethylase 4A [OS=Homo sapiens]",16,13,28,13,1064,120.6,5.85,65.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","KDM4A","ENSG00000066135","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","",1096.8,1376.1,1163.5,1092.7,1154.5,1174.7,1.062684473538093,0.08771330332792768,0.46091878304438005,0.33637559344563905,0.675080446072129,0.17064447131196755,5331]
["High","O75165","DnaJ homolog subfamily C member 13 [OS=Homo sapiens]",14,25,39,25,2243,254.3,6.74,89.93,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","DNAJC13","ENSG00000138246","","Neutrophil degranulation","",1557.4,1523.3,1577.8,1419.7,1567.1,1480.7,1.042753217683268,0.06039776404064276,0.23532840863351318,0.62832564202056,0.4647051630274332,0.33282250233957805,3954]
["High","O75167","Phosphatase and actin regulator 2 [OS=Homo sapiens]",4,2,3,2,634,69.7,8.16,6.72,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","enzyme regulator activity;cytoskeletal activity","PHACTR2","ENSG00000112419","","Platelet degranulation","",140.9,149.3,147.6,149.5,139.1,146.6,1.0059742647058825,0.008593397930606855,0.8399288626624835,0.07575749472550267,0.922645548630933,0.03496510920013114,7108]
["High","O75170","Serine/threonine-protein phosphatase 6 regulatory subunit 2 [OS=Homo sapiens]",7,4,5,4,966,104.9,4.87,2.06,"other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP6R2","ENSG00000100239","","","",91.6,82.6,72.1,76,57.9,82.2,1.1397501156871817,0.18871755563945344,0.3359678386321213,0.47370229455395396,0.5679231184324753,0.2457104521418652,4619]
["High","O75175","CCR4-NOT transcription complex subunit 3 [OS=Homo sapiens]",16,9,19,9,753,81.8,6.2,32.73,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","","CNOT3","ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615","","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",750.7,780.7,754.7,909,850.1,873.3,0.8684470445221093,-0.20349021478828652,0.004111095268786356,2.386042458946041,0.051113744997904255,1.2914622980246016,628]
["High","O75177","Calcium-responsive transactivator [OS=Homo sapiens]",9,2,2,2,396,43,6.44,2.63,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SS18L1","ENSG00000184402","","","",84.6,87,84.3,96.3,79.9,100.5,0.9248283339356703,-0.11274249657050837,0.3357473725379934,0.4739873773091824,0.5676733401421942,0.24590150123170448,4618]
["High","O75179-1","Ankyrin repeat domain-containing protein 17 [OS=Homo sapiens]",18,36,76,24,2603,274.1,6.52,163.5,"stress response;developmental processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","ANKRD17","ENSG00000132466","","","",2460.1,2535.8,2484.5,2499.4,2503.4,2442,1.00478186116484,0.006882325309795341,0.7112674789635988,0.14796704794426466,0.8508620309097256,0.07014085598160597,6527]
["High","O75182-2","Isoform 2 of Paired amphipathic helix protein Sin3b [OS=Homo sapiens]",13,10,15,9,1130,129.3,6.98,26.54,"","","","SIN3B","","","","",273,270.3,272.7,314.8,309,297.4,0.8858011289622232,-0.17494525893398766,2.4950919394232593E-3,2.602913446814727,0.041014058658982756,1.387067251780958,475]
["High","O75190","DnaJ homolog subfamily B member 6 [OS=Homo sapiens]",36,12,36,11,326,36.1,9.16,88.88,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNAJB6","ENSG00000105993","","Regulation of HSF1-mediated heat shock response","",1626.8,1713,1674,1579.2,1543.3,1514.1,1.0813527153517661,0.11283717773471781,0.015789845297412376,1.801622125014459,0.103082869633943,0.9868135000082157,1196]
["High","O75191","xylulose kinase [OS=Homo sapiens]",7,3,3,3,536,58.3,5.86,8.4,"other metabolic processes","cytosol","kinase activity;other molecular function","XYLB","ENSG00000093217","","Formation of xylulose-5-phosphate","Pentose and glucuronate interconversions; Metabolic pathways",150.4,165.6,162.3,140.8,159.3,172.7,1.0116328257191203,0.016685755808773246,0.867833524109145,0.06156357723700078,0.9334679923190804,0.02990056898166317,7259]
["High","O75208-1","Ubiquinone biosynthesis protein COQ9, mitochondrial [OS=Homo sapiens]",9,2,4,2,318,35.5,5.94,15.33,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ9","ENSG00000088682","","Ubiquinol biosynthesis","",113.3,96.4,107.6,112.3,106.3,101.8,0.9903245942571784,-0.014026626491072515,0.8677418869649322,0.06160943811501517,0.9334980233428204,0.02988659732091745,7258]
["High","O75223-1","gamma-glutamylcyclotransferase [OS=Homo sapiens]",59,10,47,10,188,21,5.14,103.14,"cell organization and biogenesis;signal transduction","cytosol","other molecular function","C7orf24; GGCT","ENSG00000006625; ENSGGOG00000024930; ENSPPAG00000031715; ENSPTRG00000019041","Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases","Glutathione synthesis and recycling","Glutathione metabolism; Metabolic pathways",1967,2118.1,1984.1,2039.2,2102.4,2148.6,0.9648659820037517,-0.05159952610842911,0.2682196462593531,0.5715094145920315,0.498633094760245,0.3022189003312966,4200]
["High","O75251","NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [OS=Homo sapiens]",14,3,12,3,213,23.5,9.99,24.45,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cell component","transporter activity;other molecular function","NDUFS7","ENSG00000115286","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",381.4,421.7,445.7,423.7,442.5,449.1,0.9494411921234698,-0.07484945149975102,0.3350351134180048,0.4749096742630484,0.567206020287897,0.24625916822707447,4612]
["High","O75290-1","Zinc finger protein 780A [OS=Homo sapiens]",3,1,1,1,641,74.5,8.65,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF780A","ENSG00000197782; ENSG00000280568","","","Herpes simplex virus 1 infection",246.5,228.2,235.7,260.7,255.7,282.2,0.889556724267468,-0.16884149028294207,0.03886977622568372,1.4103879596062046,0.16548266781359788,0.7812474862815714,1834]
["High","O75306-1","NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [OS=Homo sapiens]",29,10,26,10,463,52.5,7.55,62.3,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS2","ENSG00000158864","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",1014.7,927.9,1053,962.7,1052.5,1022.3,0.9862057613168724,-0.02003941394145309,0.7739419435211883,0.11129161626032419,0.8856718005295967,0.05272718288159496,6823]
["High","O75312","Zinc finger protein ZPR1 [OS=Homo sapiens]",28,12,22,12,459,50.9,4.73,52.98,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ZPR1","ENSG00000109917","","","",1416.4,1478.3,1463.4,1512.1,1445.2,1462.7,0.9859954751131222,-0.02034706902133391,0.49288667651880846,0.30725292133110865,0.7012498488081007,0.1541272193711685,5488]
["High","O75323-1","Protein NipSnap homolog 2 [OS=Homo sapiens]",23,6,14,5,286,33.7,9.36,26.19,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;mitochondrion","","NIPSNAP2","ENSG00000146729","","RHOJ GTPase cycle; RHOH GTPase cycle","",429.6,485.1,451.2,449.4,451.3,436.4,1.021539151895894,0.03074449840654475,0.5986424196348811,0.22283251241960428,0.7783846815169279,0.1088057194998937,6005]
["High","O75326-1","Semaphorin-7A [OS=Homo sapiens]",11,5,9,5,666,74.8,7.64,24.53,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding","SEMA7A","ENSG00000138623; ENSG00000288455","","Other semaphorin interactions","Axon guidance",304.1,265.7,254.8,191.6,190.9,203.9,1.4062073669849928,0.49180935775425255,6.930817845374011E-3,2.15921551505977,0.06583433787917309,1.181547527941185,822]
["High","O75330-1","Hyaluronan mediated motility receptor [OS=Homo sapiens]",38,27,58,26,724,84,5.83,119.76,"","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","HMMR","ENSG00000072571","","AURKA Activation by TPX2; Hyaluronan uptake and degradation","ECM-receptor interaction",2647,2621.9,2522.1,2147.1,1961.1,2005,1.2744552771052804,0.3498807475221392,0.001182559259000762,2.927177087197169,0.029689462039478937,1.5273976715653712,311]
["High","O75340","programmed cell death protein 6 [OS=Homo sapiens]",41,6,10,1,191,21.9,5.4,17.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PDCD6","ENSG00000249915","Epithelial to mesenchymal transition in colorectal cancer","","",189.3,203.4,191,190.9,198.9,180.9,1.0227790432801822,0.032494505205788726,0.561097049576992,0.25096201494616055,0.7522400005317915,0.12364357659250591,5824]
["High","O75340-2","Isoform 2 of Programmed cell death protein 6 [OS=Homo sapiens]",40,6,9,1,189,21.7,5.4,15.25,"","","","PDCD6","","","","",509.6,486.2,529,531,558,546.5,0.932314276979517,-0.10111173506019876,0.06530724134313336,1.1850386609760102,0.21800724258537205,0.6615290781265277,2339]
["High","O75347","Tubulin-specific chaperone A [OS=Homo sapiens]",44,5,7,5,108,12.8,5.29,8.45,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TBCA","ENSG00000171530","VEGFA-VEGFR2 signaling pathway","Post-chaperonin tubulin folding pathway","",320.8,254.4,338.4,353.2,305.9,257.8,0.9964009161304398,-0.005201746837080634,0.9780534111550241,0.009637427894893299,0.9876669728787414,5.3894685927732815E-3,7732]
["High","O75351","Vacuolar protein sorting-associated protein 4B [OS=Homo sapiens]",38,14,32,11,444,49.3,7.23,58.84,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS4B","ENSG00000119541","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)","Endocytosis; Necroptosis",1145.6,1109.6,1125.3,1263.6,1177.3,1179.1,0.933839779005525,-0.09875305015853596,0.057994007786681755,1.23661687746498,0.20480199583826827,0.6886658153850584,2211]
["High","O75352","Mannose-P-dolichol utilization defect 1 protein [OS=Homo sapiens]",10,2,10,2,247,26.6,8.94,17.33,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","","MPDU1","ENSG00000129255","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective MPDU1 causes CDG-1f","",291.8,280.6,324.4,256,335.2,293.3,1.0139061616732619,0.019924135227606197,0.8840168766466142,0.05353944385057565,0.9417933923941553,0.0260443608850394,7329]
["High","O75362","zinc finger protein 217 [OS=Homo sapiens]",13,11,16,10,1048,115.2,8.48,31,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","ZNF217","ENSG00000171940","","Estrogen-dependent gene expression","",785.1,757.7,782.1,951.2,909.5,899.3,0.8423550724637682,-0.24749960351686032,1.3135565913188541E-3,2.8815512119772118,0.031364678486292395,1.5035591599788622,327]
["High","O75367-1","Core histone macro-H2A.1 [OS=Homo sapiens]",42,14,65,12,372,39.6,9.79,178.74,"cell organization and biogenesis;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","H2afy; H2AFY; LOC100466888; LOC101338325; LOC101381952; LOC101564704; LOC102987354; LOC103079324; LOC103663804; LOC106989149; LOC109250833; LOC110591142; LOC111141291; LOC111182462; LOC112404331; LOC112815157; LOC112861289; LOC112917035; LOC113261754; LOC113928700; LOC115516119; LOC116529369; MACROH2A1","ENSAMEG00000017887; ENSCAFG00000001076; ENSCANG00000022762; ENSCJAG00000005818; ENSFCAG00000013924; ENSG00000113648; ENSGGOG00000001707; ENSLCNG00005003680; ENSMLEG00000037795; ENSMNEG00000031666; ENSMPUG00000010011; ENSPCOG00000013464; ENSPCTG00005011747; ENSPPAG00000029258; ENSPTRG00000017256; ENSRBIG00000034425; ENSRROG00000045755; ENSSBOG00000034640; ENSSSUG00005001976; ENSVVUG00000017487","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma","","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus",4136.4,4167,4368.4,4091.9,4382.4,4364.6,0.9869848663047458,-0.018900131253795346,0.6637984738227202,0.1779637504377086,0.8190484329342287,0.08669041626869334,6328]
["High","O75368","SH3 domain-binding glutamic acid-rich-like protein [OS=Homo sapiens]",89,8,27,8,114,12.8,5.25,54.5,"","nucleus;other cell component","other molecular function","SH3BGRL","ENSG00000131171","","","",842.4,875.4,810.3,1126.6,918.7,945.1,0.8454052969502407,-0.24228494317644747,0.08607377489992685,1.065129149953384,0.2585856230929699,0.5873956247957611,2599]
["High","O75369-1","Filamin-B [OS=Homo sapiens]",69,132,616,1,2602,278,5.73,1319.52,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLNB","ENSG00000136068","Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host","ISG15 antiviral mechanism","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer",15.9,22.3,16,18.2,9.1,15.3,1.2723004694835682,0.3474394211280335,0.3212023273184898,0.49322131663770286,0.55412014399089,0.2563960615977772,4526]
["High","O75369-8","Isoform 8 of Filamin-B [OS=Homo sapiens]",68,132,613,1,2633,281.5,5.71,1316.89,"","","","FLNB","","","","",20739.2,20467.6,19811.1,20466.8,19360.4,20101.6,1.0181732322355863,0.02598304277427919,0.4425397220392758,0.35404774126395705,0.6614376243649819,0.17951110487233918,5224]
["High","O75376-1","Nuclear receptor corepressor 1 [OS=Homo sapiens]",5,12,14,11,2440,270,7.11,29.93,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NCOR1","ENSG00000141027","Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome causing genes; 22q11.2 copy number variation syndrome; Notch signaling pathway","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis","Endocrine resistance; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer",810.2,787.5,792.2,903.2,812,783.3,0.9565339203522113,-0.06411196493989563,0.38097738587035784,0.4191008024954961,0.6098137410569401,0.21480279381457254,4878]
["High","O75379-1","Vesicle-associated membrane protein 4 [OS=Homo sapiens]",33,3,6,3,141,16.4,7.34,9.78,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP4","ENSCATG00000035773; ENSG00000117533; ENSGGOG00000023200; ENSMFAG00000031870; ENSMLEG00000033096; ENSMMUG00000023203; ENSMNEG00000025169; ENSNLEG00000015204; ENSPANG00000022546; ENSPPAG00000028975; ENSPTRG00000001680; ENSRBIG00000031656; ENSRROG00000036404","","Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network","SNARE interactions in vesicular transport",134.6,134.7,109.3,156.9,107.5,137.8,0.9413227250124315,-0.08723867060164685,0.6617866572295603,0.17928199322027336,0.8172118013045084,0.08766537037485624,6323]
["High","O75380","NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [OS=Homo sapiens]",39,3,4,3,124,13.7,8.28,14.64,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS6","ENSG00000145494","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",167.9,164.1,179.2,206,177.3,186.3,0.8974719101123595,-0.15606131001940343,0.11281299110267211,0.9476408858195329,0.3038440270885353,0.5173492965158949,2899]
["High","O75381-1","Peroxisomal membrane protein PEX14 [OS=Homo sapiens]",24,8,20,8,377,41.2,4.94,58.29,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PEX14","ENSG00000142655; ENSMFAG00000032533; ENSMMUG00000019979; ENSPANG00000017539; ENSPPAG00000038193; ENSPTRG00000000132","","Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Class I peroxisomal membrane protein import","Peroxisome",1158.7,1077.5,1171.2,1270.8,1236.6,1210,0.9166083822026148,-0.1256226159536116,0.03924484098192525,1.406217426315992,0.16626354768685425,0.7792029568764304,1843]
["High","O75382-1","Tripartite motif-containing protein 3 [OS=Homo sapiens]",4,3,6,1,744,80.8,7.83,14.47,"protein metabolism;other metabolic processes;transport;developmental processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TRIM3","ENSG00000110171; ENSPTRG00000003290","","Interferon gamma signaling","",68.6,75.2,65,62.9,52.6,60.4,1.1870380898237636,0.24736622909792358,0.06351596990929456,1.1971170657081698,0.21487551692017848,0.6678130655332283,2308]
["High","O75385","Serine/threonine-protein kinase ULK1 [OS=Homo sapiens]",3,2,2,2,1050,112.6,8.79,3.78,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","ULK1","ENSG00000177169","Target of rapamycin (TOR) signaling; Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; p53 transcriptional gene network; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease","RAB GEFs exchange GTP for GDP on RABs; Macroautophagy; TBC/RABGAPs; Receptor Mediated Mitophagy","Mitophagy; Autophagy; mTOR signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",21.8,23,22.1,15.5,22.2,19.5,1.1695804195804196,0.22599106386307152,0.1776928459834777,0.7503300567891951,0.3900550299238105,0.40887411731633994,3557]
["Medium","O75386","Tubby-related protein 3 [OS=Homo sapiens]",2,1,2,1,442,49.6,7.74,3.95,"developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TULP3","ENSG00000078246","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Genes related to primary cilium development (based on CRISPR)","Hedgehog 'off' state","",117.7,126.9,125.7,152.7,141.8,143.6,0.8452408125998631,-0.24256566515132075,7.0343642525920866E-3,2.1527751468528935,0.06665572340320268,1.176162553891374,824]
["High","O75390","citrate synthase, mitochondrial [OS=Homo sapiens]",39,16,87,16,466,51.7,8.32,160.5,"other metabolic processes","mitochondrion","other molecular function","CS","ENSG00000062485","TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)","Mitochondrial protein import; Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids",4972,5303,5097.8,4728.7,4911.8,5064.5,1.0454131247874872,0.06407317704384524,0.17914822169268244,0.746787498482455,0.39203736406291045,0.40667253952790494,3568]
["High","O75391","Sperm-associated antigen 7 [OS=Homo sapiens]",20,3,4,3,227,26,7.91,9.82,"","nucleus","nucleic acid binding activity","SPAG7","ENSG00000091640","","","",74.2,69.5,77.7,102.5,73.7,72.7,0.8895138609883488,-0.16891100819948338,0.4135481130639523,0.38347395643153936,0.6387702604952205,0.19465531169992384,5055]
["High","O75396","Vesicle-trafficking protein SEC22b [OS=Homo sapiens]",38,8,52,8,215,24.6,6.92,131.89,"","","","","","","","",1376,1374.4,1323.7,1394.1,1381.6,1388.4,0.9783866861986984,-0.03152332295767328,0.1625333276984108,0.7890575728300191,0.37215842307014413,0.42927214716388146,3410]
["High","O75400","pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",34,34,103,1,957,108.7,7.56,201.48,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","PRPF40A","ENSG00000196504","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",180.9,177.7,154.9,187.9,188.6,185.7,0.9133760227676982,-0.1307191771747857,0.11990131302281401,0.9211760609758767,0.3146855301116409,0.5021232263818097,2975]
["High","O75400-3","Isoform 3 of Pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",34,34,102,1,939,106.8,7.43,195.17,"","","","PRPF40A","","","","",5550.2,6040.2,5038.9,5290.3,4792.3,5087.8,1.0961675367821546,0.13246831473360807,0.2068832641517256,0.6842746402213224,0.4293845099672178,0.36715362677704716,3762]
["High","O75410-1","Transforming acidic coiled-coil-containing protein 1 [OS=Homo sapiens]",27,16,31,13,805,87.7,4.88,72.42,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TACC1","ENSG00000147526","","","",1536.2,1594.3,1498.8,1393.3,1338.3,1362.2,1.1308075626557232,0.1773534368220723,0.005076319182342765,2.294451078702602,0.056141501665343214,1.2507159750957704,706]
["High","O75414","Nucleoside diphosphate kinase 6 [OS=Homo sapiens]",10,2,4,2,186,21.1,8.32,11.3,"other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","NME6","ENSG00000172113","Pyrimidine metabolism","","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",106.3,106.4,97.2,126.7,112.8,118.1,0.8666107382550335,-0.2065439815971021,0.034982727081948065,1.4561463380683994,0.1560829331747717,0.8066445820960584,1750]
["High","O75420","GRB10-interacting GYF protein 1 [OS=Homo sapiens]",20,17,26,17,1035,114.5,5.39,41.2,"signal transduction","cytosol;other cell component","","GIGYF1","ENSG00000146830","","","",766.4,734.6,721.2,971.6,836.5,850.3,0.8359163406560337,-0.25856953172007624,0.03186130914444379,1.4967363835089245,0.14729017276484138,0.8318262284212978,1689]
["High","O75427","Leucine-rich repeat and calponin homology domain-containing protein 4 [OS=Homo sapiens]",33,15,22,15,683,73.4,8.22,37.93,"developmental processes","nucleus","","LRCH4","ENSG00000077454","","","",371.4,397.6,327.2,308.8,274,280.8,1.2693376563223717,0.3440758913261398,0.028548939536254477,1.5444100191906927,0.13853954002428526,0.8584262586310867,1609]
["High","O75431","Metaxin-2 [OS=Homo sapiens]",32,7,28,7,263,29.7,6.29,81.16,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus;other cell component","","MTX2","ENSG00000128654","","Mitochondrial protein import; Cristae formation","",973.1,945.6,966.8,948.4,965.7,1009.4,0.987001881306653,-0.018875260307825163,0.5602779871536718,0.25159644025863565,0.7525633104586047,0.12345695855638845,5813]
["High","O75436-1","Vacuolar protein sorting-associated protein 26A [OS=Homo sapiens]",30,9,24,8,327,38.1,6.57,44.85,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26A","ENSANAG00000022406; ENSCATG00000037809; ENSCCAG00000021117; ENSCJAG00000012907; ENSCSAG00000007798; ENSG00000122958; ENSMFAG00000042937; ENSMMUG00000004101; ENSMNEG00000039163; ENSNLEG00000011548; ENSPANG00000022152; ENSPPAG00000041182; ENSPPYG00000002386; ENSPTRG00000002567; ENSRBIG00000023684; ENSRROG00000006745; ENSSBOG00000030031","","WNT ligand biogenesis and trafficking","Endocytosis",595.6,557.9,697.5,550.3,723.1,606.6,0.9845744680851064,-0.022427766694425623,0.8902832700043269,0.050471787707841186,0.9449880060078555,0.024573703615245638,7356]
["Medium","O75438","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [OS=Homo sapiens]",19,1,1,1,58,7,8.92,2.39,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB1","ENSG00000183648","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",49,34.3,34.6,38.3,44.1,33.3,1.0190146931719966,0.027174853872272746,0.9049631710114292,0.04336909477487402,0.952028083974298,0.021350240129002898,7422]
["High","O75439","mitochondrial-processing peptidase subunit beta [OS=Homo sapiens]",36,14,45,13,489,54.3,6.83,111.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;mitochondrion","other molecular function","PMPCB","ENSG00000105819","","Mitochondrial protein import; Processing of SMDT1","",2040.8,1993.6,2013.3,1894.6,1923.5,1983.9,1.0423474663908996,0.059836279994146604,0.0507601434618544,1.2944771591422721,0.19008882501206675,0.721043413793413,2085]
["High","O75448","Mediator of RNA polymerase II transcription subunit 24 [OS=Homo sapiens]",20,15,19,15,989,110.2,6.95,36.25,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED24","ENSG00000008838","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",750,753.8,750.2,838.1,795.1,801.8,0.9256673511293635,-0.11143425679748335,0.01084195296039999,1.9648924813095319,0.08431670190717443,1.074086389459897,1004]
["High","O75449-1","Katanin p60 ATPase-containing subunit A1 [OS=Homo sapiens]",31,13,18,12,491,55.9,6.9,33.94,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNA1","ENSG00000186625","","","",443.4,469.1,441,458.5,430.5,420.5,{"$f":"AVERAGE(T642:V642)/AVERAGE(W642:Y642)","v":1.0336006109201985},{"$f":"LOG(Z642,2)","v":0.047678827864367425},{"$f":"TTEST(T642:V642,W642:Y642,2,2)","v":0.36895821136447166},{"$f":"-LOG10(AB642)","v":0.43302281975297674},{"$f":"AB642*7808/AF642","v":0.600047014024952},{"$f":"-LOG10(AD642)","v":0.22181472106350714},4801]
["High","O75461-1","transcription factor E2F6 [OS=Homo sapiens]",15,3,5,3,281,31.8,5.5,8.22,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F6","ENSG00000169016; ENSPPAG00000036538; ENSPTRG00000011661","G1 to S cell cycle control; Cell cycle","Transcriptional Regulation by E2F6; G1/S-Specific Transcription","",71.5,59.2,87.8,98,101.7,96.7,0.7371794871794871,-0.4399121679178733,0.03675557460881538,1.4346767834303058,0.1598816303875379,0.7962014316860082,1795]
["High","O75475-1","PC4 and SFRS1-interacting protein [OS=Homo sapiens]",65,40,255,39,530,60.1,9.13,511.39,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSIP1","ENSG00000164985; ENSGGOG00000016152; ENSPTRG00000020786","MECP2 and associated Rett syndrome","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection","",14467.2,15211.1,13327.8,15015.9,13547.4,14612.1,0.9960787856047657,-0.005668237025716798,0.9397249364768532,0.02699924858297716,0.9701669051978408,0.013153544320450105,7563]
["High","O75477","erlin-1 [OS=Homo sapiens]",27,10,41,7,346,38.9,7.87,78.23,"","","","","","","","",469.4,459.7,486.1,478.6,504.7,460.3,0.9803269603768356,-0.02866509520677433,0.5625736460598012,0.24982061635652986,0.7529268132387603,0.12324723648360834,5834]
["High","O75478","Transcriptional adapter 2-alpha [OS=Homo sapiens]",5,2,3,2,443,51.5,6.89,4.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TADA2A","ENSG00000277104","","HATs acetylate histones","",44,39.9,41.3,50,63.1,47,0.7820112429731418,-0.35473874558363855,0.08416537151677743,1.074866555204917,0.2552090177875721,0.5931039839234915,2575]
["High","O75487","Glypican-4 [OS=Homo sapiens]",8,3,5,2,556,62.4,6.68,10.26,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC4","ENSG00000076716","Wnt signaling","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Wnt signaling pathway",124.3,127,130.8,153,165.5,155.7,0.805778152678195,-0.3115454051244965,1.9304802262091732E-3,2.7143346424689523,0.03640867054647638,1.438795178931216,414]
["High","O75489","NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [OS=Homo sapiens]",54,15,51,15,264,30.2,7.5,109.18,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS3","ENSG00000213619; ENSG00000285387","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","RHOG GTPase cycle; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",2164.4,2373,2079.9,2482.4,2378.3,2422.7,0.9085454595381276,-0.1383693926355446,0.0736497740374135,1.1328285812647307,0.23519731520823092,0.6285676400657344,2445]
["High","O75494-1","Serine/arginine-rich splicing factor 10 [OS=Homo sapiens]",31,12,42,9,262,31.3,11.27,92.81,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Srsf10; SRSF10","ENSCATG00000031598; ENSCCAG00000022497; ENSCPOG00000034102; ENSG00000188529; ENSGGOG00000000392; ENSMLEG00000016013; ENSMNEG00000041500; ENSMUSG00000028676; ENSNLEG00000027520; ENSPANG00000021680; ENSPCOG00000022379; ENSPCTG00005007467; ENSPPAG00000032557; ENSPPYG00000001726; ENSPTRG00000044753; ENSRBIG00000028456; ENSRFEG00010001865; ENSRROG00000043248; ENSSBOG00000019550; ENSSSCG00070027414; ENSSTOG00000000956; ENSTSYG00000009439","mRNA processing; mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","Spliceosome",2593.8,2351.7,2394,2894.9,2512.4,2743.1,0.9005079505300354,-0.15118908123263552,0.11373781068418763,0.9440951356488886,0.3049673165597998,0.5157467016312528,2912]
["High","O75496","Geminin [OS=Homo sapiens]",13,2,2,2,209,23.6,4.96,2.77,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","GMNN","ENSG00000112312","DNA replication","CDT1 association with the CDC6:ORC:origin complex; Activation of the pre-replicative complex","",146.3,183.4,183.3,261.4,167.4,150.5,0.8855515277058519,-0.17535183917739014,0.5789367333563552,0.23736889370863834,0.7647332116471699,0.11649004839889038,5911]
["High","O75503","Ceroid-lipofuscinosis neuronal protein 5 [OS=Homo sapiens]",10,2,2,2,358,41.5,7.4,5.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLN5","ENSG00000102805","","","Lysosome",18.7,20.7,21.7,16.7,20.6,21.1,1.0462328767123288,0.06520401093871234,0.6137847846059535,0.21198388169692609,0.7862890234952067,0.10441778699269144,6095]
["High","O75506","Heat shock factor-binding protein 1 [OS=Homo sapiens]",42,3,4,3,76,8.5,4.36,11.36,"stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","HSBP1","ENSG00000230989","","HSF1 activation; Attenuation phase","",276.2,248.1,264.5,290,241.7,230.8,1.0344918032786885,0.04892221415293819,0.6827949336067145,0.16570971004530963,0.8309324877807398,0.08043426066278135,6416]
["High","O75509","Tumor necrosis factor receptor superfamily member 21 [OS=Homo sapiens]",4,2,2,2,655,71.8,7.83,4.16,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","","TNFRSF21","ENSG00000146072","Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer","PPARA activates gene expression","Cytokine-cytokine receptor interaction",28.1,42,41.3,39.3,31.1,45.6,0.960344827586207,-0.058375572674902586,0.8159584206407774,0.08833197132745339,0.9097534411485348,0.04107629301680951,7003]
["High","O75521","Enoyl-CoA delta isomerase 2, mitochondrial [OS=Homo sapiens]",28,6,15,6,394,43.6,9,42.82,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ECI2","ENSG00000198721","","","Fatty acid degradation; Peroxisome",347.3,384,365.9,396.2,378.3,403.7,0.9312510609404174,-0.1027579308143476,0.10640429977686566,0.973040821931613,0.29263993401118954,0.5336664097988348,2839]
["High","O75525-1","KH domain-containing, RNA-binding, signal transduction-associated protein 3 [OS=Homo sapiens]",10,4,18,2,346,38.8,7.61,29.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHDRBS3","ENSCCAG00000031191; ENSG00000131773; ENSGGOG00000000940; ENSRBIG00000036854; ENSRROG00000044792","","PTK6 Regulates Proteins Involved in RNA Processing","",83.4,110.1,93.1,95.1,93.8,80.3,1.0646359583952454,0.09036019965182888,0.5595944534847456,0.25212659874223015,0.7524218172565684,0.12353862011691898,5807]
["High","O75529-1","TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L [OS=Homo sapiens]",12,4,4,4,589,66.1,5.88,7.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","TAF5L","ENSG00000135801; ENSGGOG00000028544; ENSPPAG00000034307; ENSPTRG00000002091","","HATs acetylate histones","Basal transcription factors",139.5,125.6,116.8,112.8,121.6,117.1,1.0864864864864865,0.11967023066261649,0.2255732320534408,0.64671243776145,0.45230503232492697,0.34456858028682746,3894]
["High","O75530","Polycomb protein EED [OS=Homo sapiens]",20,7,11,7,441,50.2,7.03,18.24,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","EED","ENSG00000074266","Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma","Transcriptional Regulation by E2F6; HCMV Early Events; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis","",500.5,487.2,528.5,551.3,597.6,603.7,0.8651146867511126,-0.20903669388440374,0.01851293550881196,1.7325247117604512,0.11240202212504181,0.9492258756900191,1286]
["High","O75531","Barrier-to-autointegration factor [OS=Homo sapiens]",25,3,5,3,89,10.1,6.09,2.34,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BANF1","ENSG00000175334","Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation","",134.9,121.7,140.5,172,118.7,131.5,0.9405495026054004,-0.08842421782268757,0.6484585304580329,0.18811779223851208,0.8095881365232365,0.09173586448679112,6254]
["High","O75533-1","splicing factor 3B subunit 1 [OS=Homo sapiens]",49,55,274,55,1304,145.7,7.09,581.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101357717; LOC111145177; Sf3b1; SF3B1","ENSANAG00000021577; ENSCANG00000029415; ENSCATG00000035735; ENSCCAG00000020506; ENSCGRG00001016990; ENSCGRG00015028775; ENSCJAG00000003902; ENSCSAG00000011505; ENSDLEG00000016863; ENSFCAG00000005038; ENSG00000115524; ENSLAFG00000001956; ENSLCNG00005009987; ENSMMNG00015005194; ENSMMUG00000022430; ENSMNEG00000042333; ENSMPUG00000007799; ENSMUSG00000025982; ENSNLEG00000006861; ENSPANG00000013417; ENSPCTG00005000567; ENSPPAG00000035007; ENSRNOG00000013516; ENSRROG00000031308; ENSSBOG00000020080; ENSSSCG00000016075; ENSSSCG00070023758; ENSSSUG00005005995; ENSSTOG00000011034; ENSUMAG00000020945","mRNA processing; mRNA processing; mRNA processing","B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway","Spliceosome",13192.7,13398,13665.6,14551.2,14815.7,14641.3,0.9147454338055182,-0.12855778590001712,1.3583628138835228E-3,2.866984216047592,0.031565764436912336,1.5007836887788006,336]
["High","O75534","cold shock domain-containing protein E1 [OS=Homo sapiens]",47,39,211,39,798,88.8,6.25,409.73,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity","CSDE1","ENSG00000009307","","","",9316.3,9624.4,9517,9453,10213.1,10086.7,0.9564713237073484,-0.06420637959916808,0.1617072305300809,0.7912705607422705,0.3714651532741606,0.43008192066669476,3399]
["Low","O75541","zinc finger protein 821 [OS=Homo sapiens]",2,1,1,1,412,46.8,6.55,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF821","ENSG00000102984","","","",11,14.9,13.8,12.4,20,8.6,0.9682926829268294,-0.04648490236248813,0.9086486968298996,0.0416039919350038,0.9532082527002359,0.020812206268239947,7443]
["High","O75553-5","Isoform DAB553 of Disabled homolog 1 [OS=Homo sapiens]",17,6,6,6,553,59.6,5.36,7.81,"","","","DAB1","","","","",205.2,171,187.1,177.7,186.1,200.5,0.998227892964735,-2.5588780048031493E-3,0.9790165799981296,0.009209953201228947,0.9881284199360647,0.005186609617538782,7736]
["High","O75554","WW domain-binding protein 4 [OS=Homo sapiens]",18,5,7,5,376,42.5,5.57,13.15,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","WBP4","ENSG00000120688","","mRNA Splicing - Major Pathway","",363.9,391.7,324.9,364.8,311.3,339,1.0644271500344793,0.09007721434590112,0.42864741390000194,0.36789979209902646,0.6516508971439282,0.18598500250118793,5136]
["High","O75569-1","Interferon-inducible double-stranded RNA-dependent protein kinase activator A [OS=Homo sapiens]",30,9,38,9,313,34.4,8.41,73.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function","PRKRA","ENSCATG00000032736; ENSG00000180228; ENSMNEG00000031681; ENSPANG00000001046; ENSPTRG00000012688","VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","",2055.6,1860.6,1853.3,1776.4,1676.3,1689.2,1.1220560493202902,0.1661447437334879,0.0462638367819329,1.3347583528856595,0.18152162693132265,0.7410716246367307,1990]
["High","O75581","Low-density lipoprotein receptor-related protein 6 [OS=Homo sapiens]",11,13,17,13,1613,180.3,5.31,37.04,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","LRP6","ENSG00000070018; ENSG00000281324","MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Type I collagen synthesis in the context of osteogenesis imperfecta; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by WNT ligand antagonists; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","mTOR signaling pathway; Wnt signaling pathway; Parathyroid hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Pathways in cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer",647.6,654,670.1,713.9,704,699.9,0.9310133157049767,-0.10312629298497192,0.003479929716321763,2.458429527352806,0.047668931973754956,1.321764578366662,570]
["High","O75586","Mediator of RNA polymerase II transcription subunit 6 [OS=Homo sapiens]",9,2,3,2,246,28.4,8.62,2.57,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MED6","ENSG00000133997","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway","",117.6,108.6,112.5,102.4,113,114.9,1.025431425976385,0.0362310172086318,0.5819657001866565,0.23510261098350058,0.7669178374780445,0.11525116100700665,5925]
["High","O75592-1","E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",3,13,16,13,4640,509.8,7.03,32.47,"","","","","","","","",824.3,853.8,813.5,789.2,807.9,761.9,1.0562102585841457,0.07889705895959545,0.06986611127605043,1.1557334287558547,0.2275822264678355,0.6428616581308731,2397]
["High","O75600-1","2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [OS=Homo sapiens]",3,1,1,1,419,45.3,8.05,2.88,"other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","GCAT","ENSG00000100116","","Threonine catabolism","Glycine, serine and threonine metabolism; Metabolic pathways",17.3,12.6,14.1,9.4,14.7,14.2,1.1488250652741514,0.20015913159970247,0.43366501216100484,0.36284561506211127,0.6545633897067709,0.18404828881255847,5173]
["High","O75607","Nucleoplasmin-3 [OS=Homo sapiens]",44,5,36,5,178,19.3,4.63,63.14,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NPM3","ENSG00000107833","","","",712.5,788.4,733.3,709.7,694.5,676.2,1.0739280907517783,0.10289739500954687,0.10582563664990645,0.9754091101186856,0.2915619516451904,0.5352691513714918,2834]
["High","O75608","Acyl-protein thioesterase 1 [OS=Homo sapiens]",56,8,40,8,230,24.7,6.77,72.67,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LYPLA1","ENSG00000120992","","RAS processing; eNOS activation","Glycerophospholipid metabolism; Choline metabolism in cancer",1400.3,1462.7,1386.7,1503.3,1509.9,1596.5,0.9219038115278652,-0.1173118625309357,0.034437270992412554,1.462971271849504,0.15488837091518273,0.8099811880313418,1736]
["High","O75616-1","GTPase Era, mitochondrial [OS=Homo sapiens]",7,2,4,2,437,48.3,8.84,9.83,"cell organization and biogenesis","other membranes;cytosol;mitochondrion","translation activity;nucleic acid binding activity;other molecular function","ERAL1","ENSG00000132591","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",77.4,92.5,93.1,91.6,105.1,91.5,0.9125607217210272,-0.1320075359950826,0.286726316246929,0.5425324449107785,0.5182312678833383,0.28547638706705525,4320]
["High","O75643-1","U5 small nuclear ribonucleoprotein 200 kDa helicase [OS=Homo sapiens]",49,87,348,87,2136,244.4,6.06,756.77,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","SNRNP200","ENSCATG00000015790; ENSG00000144028; ENSGGOG00000005174; ENSMLEG00000019083; ENSPPAG00000041559; ENSPPYG00000012068; ENSPTRG00000012230; ENSRBIG00000044690; ENSRROG00000037952","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",14483.5,13954.2,15032.8,13589.5,14386.9,13993,1.0357665346657325,0.05069885125108208,0.26589873553570464,0.5752837279229337,0.4963273552624389,0.3042317878449286,4183]
["High","O75648-1","Mitochondrial tRNA-specific 2-thiouridylase 1 [OS=Homo sapiens]",14,4,4,4,421,47.7,8.03,6.21,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TRMU","ENSG00000100416","","tRNA modification in the mitochondrion","",127.6,114.3,113,106.5,122.2,118.7,1.0215889464594128,0.03081482035055183,0.726586919985592,0.13871242457020913,0.8591838060347572,0.06591391718458417,6603]
["High","O75663","TIP41-like protein [OS=Homo sapiens]",31,8,25,8,272,31.4,5.91,37.38,"stress response;signal transduction;other biological processes","cytosol","","TIPRL","ENSG00000143155","Ciliary landscape","","",1262,1339.7,1350,1283.5,1322.7,1282.1,1.0163053262351156,0.023333892730688182,0.5303114105832608,0.27546902817083696,0.7292482377305566,0.13712461170204,5678]
["High","O75665","Oral-facial-digital syndrome 1 protein [OS=Homo sapiens]",9,7,7,7,1012,116.6,6.1,18.72,"cell organization and biogenesis;transport;developmental processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","OFD1","ENSG00000046651","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state","",165.3,135.6,146.1,184.3,192.5,178.4,0.8051152737752161,-0.31273273650758093,0.019884933875507837,1.7014758488595354,0.1163879787855811,0.9340918737814301,1334]
["High","O75674","TOM1-like protein 1 [OS=Homo sapiens]",11,4,5,4,476,53,5.24,16.3,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TOM1L1","ENSG00000141198","","","",154.9,145.2,161,169,187.8,190.9,0.8418842431988315,-0.24830621461660982,0.024869808522196363,1.6043275584403032,0.12783638244984147,0.8933455276444542,1519]
["High","O75676","Ribosomal protein S6 kinase alpha-4 [OS=Homo sapiens]",3,2,3,2,772,85.6,8.28,4.53,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","RPS6KA4","ENSG00000162302","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Interferon type I signaling pathways","Recycling pathway of L1","MAPK signaling pathway; TNF signaling pathway",70.8,66.6,59.8,86.2,75,77.4,0.8264878457669741,-0.2749344913173164,0.04190988754904552,1.377683504446388,0.17259092931590053,0.7629820327898,1896]
["High","O75683","Surfeit locus protein 6 [OS=Homo sapiens]",25,6,19,6,361,41.4,10.64,38.08,"other biological processes","nucleus;other cell component","nucleic acid binding activity","SURF6","ENSG00000148296; ENSG00000281309","","","",450,476.2,489.2,592,497.7,480.8,0.9012416427889207,-0.1500141185787082,0.22923490210501965,0.6397192582681934,0.45800054136028495,0.3391340086562934,3908]
["High","O75688","Protein phosphatase 1B [OS=Homo sapiens]",29,13,39,1,479,52.6,5.05,86.64,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus","other molecular function","PPM1B","ENSG00000138032","MAPK signaling pathway","ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","MAPK signaling pathway",1258.6,1233.7,1208.2,1252.6,1239.8,1228.1,0.9946243784437577,-0.007776302567429286,0.7014148699944619,0.15402503131438805,0.8435994000179851,0.07386373780994689,6492]
["High","O75688-2","Isoform Beta-2 of Protein phosphatase 1B [OS=Homo sapiens]",35,13,38,1,387,42.7,5.2,82.57,"","","","PPM1B","","","","",61.7,58.4,62.5,68.1,59.7,59.2,0.9764705882352941,-0.03435150479077704,0.6655071228978127,0.17684729192685578,0.8201198888235671,0.08612265584965745,6336]
["High","O75691","Small subunit processome component 20 homolog [OS=Homo sapiens]",20,40,75,40,2785,318.2,7.39,149.83,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","","UTP20","ENSG00000120800","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2491,2248.5,2432.2,2736.6,2798.4,2789,0.8615689572321,-0.21496182510518697,0.007051242329774103,2.151734359684716,0.06649287453004371,1.177224891810961,828]
["High","O75694","nuclear pore complex protein nup155 [OS=Homo sapiens]",24,26,67,26,1391,155.1,6.16,169.68,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUP155","ENSG00000113569","","ISG15 antiviral mechanism; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis",3156.8,3261.9,3408.5,3211,3698.9,3316.9,0.9609261939218525,-0.057502469041333576,0.46520918166550457,0.33235172234575455,0.6790714695165937,0.1680845155821362,5349]
["High","O75695","Protein XRP2 [OS=Homo sapiens]",23,7,16,7,350,39.6,5.12,27.49,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","RP2","ENSG00000102218","Joubert syndrome; Ciliopathies","Trafficking of myristoylated proteins to the cilium","",920.3,1073.4,924.5,716.4,646.2,688.2,1.4229568948702944,0.5088919594759439,0.005995104813609387,2.222203219641986,0.06199970646975111,1.2076103666125386,755]
["High","O75717","WD repeat and HMG-box DNA-binding protein 1 [OS=Homo sapiens]",35,31,103,31,1129,125.9,5.62,237.63,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","WDHD1","ENSG00000198554","Mesodermal commitment pathway","","",3841.4,3742.6,3865.8,4326.9,4461.1,4327.5,0.872997598261599,-0.19595041008287267,6.8325587014101633E-4,3.1654166284111525,0.023501593982647822,1.6289026809456397,227]
["High","O75718","Cartilage-associated protein [OS=Homo sapiens]",38,14,64,14,401,46.5,5.73,125.6,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cell component","","CRTAP","ENSG00000170275","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",3220.3,3361.8,3281.7,3270.6,3263.6,3253.1,1.0078162516730866,0.011232625975894476,0.5701912519987684,0.24397945001815224,0.7588296055235015,0.11985573357584851,5867]
["High","O75746","Calcium-binding mitochondrial carrier protein Aralar1 [OS=Homo sapiens]",10,6,15,2,678,74.7,8.38,27.89,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A12","ENSG00000115840","","Mitochondrial protein import; Gluconeogenesis; Aspartate and asparagine metabolism","",223,255.1,206.3,243.7,246.4,247.4,0.928,-0.10780328953451485,0.28527423974365357,0.5447374433526875,0.5166831973830774,0.2867756615479402,4311]
["High","O75781","Paralemmin-1 [OS=Homo sapiens]",17,5,6,5,387,42.1,5,11.9,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","signal transduction activity or receptor binding","PALM","ENSG00000099864","","","",300.4,259.9,281,306.3,261.3,253.1,1.0251005239429756,0.03576539098243944,0.7516438818801574,0.12398787319352839,0.8745098241275918,0.05823530735118513,6711]
["High","O75787","Renin receptor [OS=Homo sapiens]",25,8,15,8,350,39,6.1,37.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ATP6AP2","ENSG00000182220","ACE inhibitor pathway; Oxidative phosphorylation","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","Renin-angiotensin system",771.1,832.6,779.9,775.4,729.3,729.5,1.0668695730015219,0.0933838145078886,0.1126466394071588,0.9482817600759437,0.3035006764979627,0.5178403365524641,2898]
["High","O75792","Ribonuclease H2 subunit A [OS=Homo sapiens]",21,7,11,7,299,33.4,5.25,31.7,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RNASEH2A","ENSG00000104889","","","DNA replication",396.5,383,388.1,416.9,400.5,405.1,0.9550920245398773,-0.06628834922469072,0.04335031076171862,1.3630077848863675,0.17583336437792155,0.7548987140722516,1925]
["High","O75794","Cell division cycle protein 123 homolog [OS=Homo sapiens]",35,9,16,9,336,39.1,4.81,39.97,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","other cell component","","CDC123","ENSG00000151465","","","",631.5,657.1,666.6,797.3,793.1,767.1,0.8293531283138916,-0.2699415806310921,6.8401734717147666E-4,3.1649328841200637,0.023424594064538992,1.6303279264618817,228]
["High","O75808-1","Calpain-15 [OS=Homo sapiens]",9,5,5,5,1086,117.2,6.71,12.48,"protein metabolism","other cell component","other molecular function","CAPN15","ENSG00000103326","","Degradation of the extracellular matrix","",210.9,210.3,194.9,177.9,177,183.1,1.1451672862453532,0.19555836287069464,0.009494971465849747,2.022506336060468,0.07836864398029052,1.1058576678036252,946]
["High","O75815-1","Breast cancer anti-estrogen resistance protein 3 [OS=Homo sapiens]",6,4,4,4,825,92.5,7.96,3.91,"developmental processes;signal transduction;other biological processes","other membranes;other cell component","enzyme regulator activity;other molecular function","BCAR3","ENSG00000137936","","","",137.8,121.4,128.9,155.1,133.1,131.3,0.9251489868891537,-0.11224237754173755,0.30950920294685985,0.5093264331394444,0.543555523303887,0.26475608684378077,4446]
["High","O75817","Ribonuclease P protein subunit p20 [OS=Homo sapiens]",11,1,4,1,140,15.6,8.94,11.68,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP7","ENSG00000172336","","tRNA processing in the nucleus","Ribosome biogenesis in eukaryotes",109.4,108.1,95.9,96.7,90.7,88.7,1.1350959797174933,0.1828142918845106,0.06507766344164254,1.1865680484306003,0.217519861366586,0.6625010822123267,2336]
["High","O75818-1","Ribonuclease P protein subunit p40 [OS=Homo sapiens]",8,2,8,2,363,41.8,6.67,17.47,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP40","ENSG00000124787","","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","Ribosome biogenesis in eukaryotes",161,159.6,174.1,175.2,189.1,192.9,0.8878320172290023,-0.17164135844262945,0.042451769173567605,1.372104205860372,0.17399654262845976,0.7594593812133748,1905]
["High","O75820-1","Zinc finger protein 189 [OS=Homo sapiens]",9,5,9,1,626,72.9,8.5,7.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF189","ENSG00000136870; ENSGGOG00000003650; ENSPPAG00000034345; ENSPPYG00000019452; ENSPTRG00000021200","","Generic Transcription Pathway","Herpes simplex virus 1 infection",139.5,146.3,137.6,129.5,142,160.4,0.9803195184070386,-0.028676047199432786,0.7770788936716159,0.10953488680155056,0.8867921662946472,0.052178151991958945,6842]
["High","O75821","Eukaryotic translation initiation factor 3 subunit G [OS=Homo sapiens]",56,22,117,22,320,35.6,6.13,228.78,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3G","ENSG00000130811","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",4410.1,4477.3,4131.2,4463.7,4291.8,4530.1,0.9799030529294875,-0.029289072166077155,0.523749670954228,0.280876236871105,0.7237942355417013,0.14038488003190813,5650]
["High","O75822","Eukaryotic translation initiation factor 3 subunit J [OS=Homo sapiens]",40,8,12,8,258,29,4.83,19.73,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3J","ENSG00000104131","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",544.3,583.9,553.2,1608.4,510.5,463.9,0.650998915905219,-0.6192729539841116,0.4669627942392504,0.3307177209334267,0.680613309206658,0.16709956264765077,5357]
["High","O75828","Carbonyl reductase [NADPH] 3 [OS=Homo sapiens]",35,6,16,4,277,30.8,6.18,47,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CBR3","ENSG00000159231","Nuclear receptors meta-pathway; NRF2 pathway","Phase I - Functionalization of compounds","Arachidonic acid metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways",240.4,253.2,231.6,270.1,242.5,272.4,0.9238216560509555,-0.11431372892219364,0.1572837874694569,0.8033160413654452,0.3661514050571018,0.4363392949768768,3354]
["High","O75832","26S proteasome non-ATPase regulatory subunit 10 [OS=Homo sapiens]",52,10,64,10,226,24.4,6.1,103.3,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PSMD10","ENSG00000101843","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway","Degradation of DVL; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","",2207.1,2357,2140.7,2173.9,2139.3,2187.8,1.0313490232271956,0.044532643926058546,0.358753172124841,0.4452042501737039,0.5919578968619523,0.22770918147096125,4732]
["High","O75844","caax prenyl protease 1 homolog [OS=Homo sapiens]",16,7,48,7,475,54.8,7.49,80.53,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZMPSTE24","ENSG00000084073","Adipogenesis; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy","","Terpenoid backbone biosynthesis",1813,1687,1907.6,1751,1859.6,1847.1,0.9908203089213405,-0.013304654966970211,0.8291799440687724,0.08135121102294307,0.9171606464497769,0.03755458825999136,7059]
["High","O75864-1","Protein phosphatase 1 regulatory subunit 37 [OS=Homo sapiens]",9,4,5,4,691,74.7,5.06,9.53,"other biological processes","","enzyme regulator activity","PPP1R37","ENSG00000104866; ENSPPAG00000031033","","","",161.2,133.5,145,112.9,116.8,118.8,1.2616929698708752,0.3353608764568618,0.020860092510805093,1.6806837698863297,0.11802579878577257,0.928023051628931,1380]
["Medium","O75865-1","Trafficking protein particle complex subunit 6A [OS=Homo sapiens]",6,1,1,1,159,17.6,5.26,0,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC6A","ENSG00000007255","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",21.4,14.1,23.6,16.5,13.5,18.3,1.22360248447205,0.29113494134175955,0.3227657841195827,0.4911125103677519,0.5555897800718037,0.2552457515939667,4536]
["High","O75874","Isocitrate dehydrogenase [NADP] cytoplasmic [OS=Homo sapiens]",73,28,435,27,414,46.6,7.01,794.24,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","IDH1","ENSG00000138413","Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism","Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration","Citrate cycle (TCA cycle); Glutathione metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Peroxisome; Central carbon metabolism in cancer",14200.5,14257.6,13939.9,14493.7,14094.8,14528.3,0.9833290040077184,-0.024253898019908997,0.23156461046425325,0.6353278121919023,0.4612388975777779,0.33607407455372407,3920]
["High","O75879","Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial [OS=Homo sapiens]",13,5,11,5,557,61.8,8.63,16.71,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","other molecular function","GATB","ENSG00000059691","","","Aminoacyl-tRNA biosynthesis; Metabolic pathways",276.8,292.8,291,291.6,277.5,275.7,1.0187026515151516,0.026733005589856546,0.5012558005866943,0.29994058863965745,0.70633555152155,0.1509889341409259,5541]
["High","O75880","Protein SCO1 homolog, mitochondrial [OS=Homo sapiens]",8,3,5,3,301,33.8,8.88,9.23,"cell organization and biogenesis;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO1","ENSG00000133028","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","",403.7,338.7,328.3,364.3,351.6,337.1,1.016809116809117,0.02404887085709977,0.824102774040171,0.08401862396399704,0.9145245110440101,0.03880465009078526,7036]
["High","O75882-1","Attractin [OS=Homo sapiens]",5,6,10,6,1429,158.4,7.31,11.5,"cell adhesion;stress response;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","ATRN","ENSG00000088812","","","",241.3,242,256.6,213.1,218.4,216.7,{"$f":"AVERAGE(T706:V706)/AVERAGE(W706:Y706)","v":1.1414686825053995},{"$f":"LOG(Z706,2)","v":0.19089127812244647},{"$f":"TTEST(T706:V706,W706:Y706,2,2)","v":0.004263262360821552},{"$f":"-LOG10(AB706)","v":2.3702579400831025},{"$f":"AB706*7808/AF706","v":0.051449076527503364},{"$f":"-LOG10(AD706)","v":1.2886224160931676},647]
["High","O75884-1","Putative hydrolase RBBP9 [OS=Homo sapiens]",6,2,3,2,186,21,6.2,7.2,"other biological processes","nucleus","other molecular function","RBBP9","ENSG00000089050; ENSPPAG00000038694; ENSPTRG00000013289","","","",291.7,270.4,287.1,266.4,312.1,272.7,0.9976503759398495,-0.003393779595812091,0.9681557141799876,0.01405478693695476,0.9814801111811663,0.008118496565031672,7702]
["High","O75886","Signal transducing adapter molecule 2 [OS=Homo sapiens]",17,8,16,7,525,58.1,5.07,18.11,"cell organization and biogenesis;other metabolic processes;transport;signal transduction","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STAM2","ENSG00000115145","EGF/EGFR signaling pathway","Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell","Endocytosis; JAK-STAT signaling pathway",499.9,455.2,416.3,439.2,430.8,462.1,1.0295022896178965,0.04194703853423861,0.639608146879154,0.19408601315261964,0.8027745395969191,0.09540640983665388,6221]
["High","O75907","Diacylglycerol O-acyltransferase 1 [OS=Homo sapiens]",10,4,6,4,488,55.2,9.32,20.93,"cell organization and biogenesis;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","DGAT1","ENSG00000185000; ENSG00000285482","Triacylglyceride synthesis; Statin inhibition of cholesterol production; Glycerolipids and glycerophospholipids; Congenital generalized lipodystrophy (CGL); Vitamin A and carotenoid metabolism","Neutrophil degranulation; Acyl chain remodeling of DAG and TAG; Triglyceride biosynthesis","Glycerolipid metabolism; Retinol metabolism; Metabolic pathways; Fat digestion and absorption",356.8,375.4,358.6,255,272.1,265.3,1.3765774861181221,0.46108582002577686,2.1055659902887889E-4,3.6766311428596397,0.014421280045767424,1.840996189537477,114]
["High","O75909","Cyclin-K [OS=Homo sapiens]",18,7,20,7,580,64.2,8.41,44.16,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNK","ENSG00000090061","Male infertility","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes","",817,809.2,795.5,799.5,799.4,804.6,1.007572290409819,0.010883351680586064,0.4044216673600396,0.39316558462697654,0.6304101375019344,0.2003768116578554,5009]
["High","O75915","PRA1 family protein 3 [OS=Homo sapiens]",20,3,9,3,188,21.6,9.77,6.29,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","ARL6IP5","ENSG00000144746","","Glutamate Neurotransmitter Release Cycle","",89.9,122.5,98.9,106.9,110.7,116.4,0.9320359281437126,-0.10154252589223495,0.49559435281062514,0.30487365095851815,0.7029247423697296,0.15309116960765332,5505]
["High","O75923-1","dysferlin [OS=Homo sapiens]",16,24,35,24,2080,237.1,5.64,65.88,"cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYSF","ENSG00000135636","","Smooth Muscle Contraction","",871.2,893.5,884.2,884.2,916.2,875,0.9900949390745308,-0.014361224680020804,0.5639504400077826,0.24875906016003424,0.7536068861168521,0.12285514181166632,5843]
["High","O75925","E3 SUMO-protein ligase PIAS1 [OS=Homo sapiens]",11,5,9,4,651,71.8,7.3,16,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS1","ENSG00000033800","Androgen receptor signaling pathway; Interleukin-11 signaling pathway; Mesodermal commitment pathway; TGF-beta signaling pathway; Immune response to tuberculosis; Interferon type I signaling pathways","SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway; Hepatitis C",220,184.3,201.2,195.2,210,189.5,1.0181604170169833,0.025964884205487246,0.7788466734915611,0.10854803065936525,0.8876419247733337,0.05176219352011322,6851]
["High","O75928-1","E3 SUMO-protein ligase PIAS2 [OS=Homo sapiens]",10,4,7,3,621,68.2,7.52,10.59,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS2","ENSG00000078043; ENSPTRG00000009998","Androgen receptor signaling pathway; TGF-beta signaling pathway","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway",33.6,31.1,33,38.1,29.7,24.5,1.058504875406284,0.08202791432261124,0.6784678690851582,0.16847071485676113,0.827730800283893,0.08211088418201291,6400]
["High","O75934","Pre-mRNA-splicing factor spf27 [OS=Homo sapiens]",48,10,26,10,225,26.1,5.66,64.74,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","","BCAS2","ENSG00000116752","","mRNA Splicing - Major Pathway","Spliceosome",1150.6,1166.3,1083.1,1218.6,1133.7,1107.7,0.9826589595375722,-0.025237291499022946,0.6595430360557292,0.1807568609034708,0.8156021579859254,0.088521633801034,6314]
["High","O75935","Dynactin subunit 3 [OS=Homo sapiens]",24,4,11,4,186,21.1,5.47,18.4,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DCTN3","ENSG00000137100","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection",285.4,293.1,276.9,276.3,273.5,294.5,1.013146985668601,0.018843493104599436,0.6706399917398094,0.17351055219849185,0.8234560552766838,0.08435957252346989,6359]
["High","O75937","DnaJ homolog subfamily C member 8 [OS=Homo sapiens]",16,4,8,4,253,29.8,9.06,12.9,"","non-structural extracellular;cytosol;nucleus","other molecular function","DNAJC8","ENSG00000126698; ENSG00000285317","mRNA processing","mRNA Splicing - Major Pathway","",502.6,431.3,506.1,1255.9,544.5,430.9,0.6453636893290906,-0.6318156864125584,0.36657860878675697,0.4358328813184906,0.5982955220332354,0.2230842476402096,4784]
["High","O75940","Survival of motor neuron-related-splicing factor 30 [OS=Homo sapiens]",37,7,16,7,238,26.7,7.24,32.33,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","SMNDC1","ENSG00000119953","","mRNA Splicing - Major Pathway","Spliceosome",721.9,862.5,710.4,941.3,822.8,778.3,0.9026117054751418,-0.14782260669654998,0.29752380380317145,0.5264782822150712,0.5296547788634662,0.27600710489793984,4386]
["High","O75943-1","cell cycle checkpoint protein RAD17 [OS=Homo sapiens]",9,6,8,6,681,77,7.06,13.11,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","RAD17","ENSG00000152942; ENSG00000276618","miRNA regulation of DNA damage response; Gastric cancer network 2; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","",203.2,218.2,227.1,233.2,233.8,221.1,0.9424502252579566,-0.08551166925912303,0.17887474934026018,0.7474509618147982,0.3917683149645867,0.4069706913440471,3565]
["High","O75947-1","ATP synthase subunit d, mitochondrial [OS=Homo sapiens]",41,6,20,6,161,18.5,5.3,16.06,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5PD","ENSG00000167863; ENSGGOG00000013716; ENSPTRG00000009628","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",541.9,527.8,498.4,744.8,500.7,463.6,0.917500438827453,-0.12421924691076111,0.6258592219688911,0.20352334410227224,0.7947160196996426,0.09978803248828515,6149]
["High","O75953","dnaJ homolog subfamily B member 5 [OS=Homo sapiens]",30,8,18,8,348,39.1,9.04,37.35,"stress response;other biological processes","cytosol","other molecular function","DNAJB5","ENSG00000137094","","","",379.3,376.7,373.1,373.6,392.9,329.2,1.0304827963858718,0.04332041969913458,0.5883099072698007,0.23039383793521884,0.7703377085297005,0.11331884262232264,5963]
["High","O75954","tetraspanin-9 [OS=Homo sapiens]",14,2,3,2,239,26.8,7.68,9.46,"","plasma membrane;other membranes","","TSPAN9","ENSG00000011105","","","",26.2,25,17.5,23.7,22.9,28.2,0.9184491978609627,-0.12272817106953636,0.557683995505216,0.25361181877454075,0.7510170122291698,0.12435022513488397,5798]
["High","O75955","Flotillin-1 [OS=Homo sapiens]",34,13,37,12,427,47.3,7.49,78.73,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","FLOT1","ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules","Insulin signaling pathway",992.6,934.4,1043.6,996.9,1135,988.9,0.9518713150474237,-0.07116154834124525,0.4290231840494919,0.36751923827516975,0.6519682796921823,0.18577353354686174,5138]
["High","O75962-1","Triple functional domain protein [OS=Homo sapiens]",5,12,14,12,3097,346.7,6.37,23.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;kinase activity;other molecular function","TRIO","ENSG00000038382","Microtubule cytoskeleton regulation; Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; G alpha (q) signalling events; DCC mediated attractive signaling","",357.1,349.6,378.8,325.7,336.4,315,1.1109405383277045,0.15178160038544722,0.027988647281702646,1.553018090897488,0.1365845987347089,0.8645982688947773,1600]
["High","O75964","ATP synthase subunit g, mitochondrial [OS=Homo sapiens]",39,4,21,4,103,11.4,9.64,39.98,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5MG","ENSG00000167283","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis",647.3,722.9,732,598.7,698.4,654.3,1.0772778517987085,0.10739039817672129,0.27111958287330384,0.5668391123469904,0.5018733293207104,0.29940588309182253,4218]
["Low","O75969","A-kinase anchor protein 3 [OS=Homo sapiens]",1,1,1,1,853,94.7,6.18,0,"developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","AKAP3","ENSG00000111254","G protein signaling pathways","","",27.3,40.7,30.7,29.9,32.5,36.6,0.996969696969697,-4.3784405105743345E-3,0.9832214485628521,0.007348656066588743,0.9903241834853908,0.004222615450662258,7752]
["High","O75970","multiple PDZ domain protein [OS=Homo sapiens]",11,16,24,16,2070,221.5,5.06,47.36,"","plasma membrane;other membranes;other cell component","other molecular function","MPDZ","ENSG00000107186","","","Tight junction",1320,1175.8,1198,1440,1353.4,1394.2,0.8820804279300792,-0.18101788844041583,0.03269822373636811,1.4854758388518332,0.15026941196795893,0.8231294130622433,1699]
["High","O75976","Carboxypeptidase D [OS=Homo sapiens]",15,16,26,16,1380,152.8,6.05,45.84,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","CPD","ENSG00000108582","","Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle; RND1 GTPase cycle","",799,767.8,704.5,747.8,742,716.9,1.0292744822585762,0.04162776492147958,0.5041336544718206,0.29745430937888306,0.7092388421830585,0.14920748784292392,5550]
["High","O76003","glutaredoxin-3 [OS=Homo sapiens]",36,11,67,11,335,37.4,5.39,164.17,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","GLRX3","ENSG00000108010","","Iron uptake and transport","",3352.3,3289.1,3321.3,3385.1,3507.9,3459.3,0.9623658510669127,-0.05534264457048561,0.03170904332111513,1.4988168606732652,0.14676005349808352,0.833392138603755,1687]
["High","O76021","Ribosomal L1 domain-containing protein 1 [OS=Homo sapiens]",48,24,127,24,490,54.9,10.13,233.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RSL1D1","ENSG00000171490","","","",5783.3,6013.3,6033.3,6517.9,6465,6718.9,0.9049883766965455,-0.14402883196216953,0.004991925558909113,2.3017318996068927,0.05568136394851765,1.254290134962514,700]
["High","O76024","Wolframin [OS=Homo sapiens]",18,14,33,14,890,100.2,8.05,64.28,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","WFS1","ENSG00000109501","CAMKK2 pathway","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes","Protein processing in endoplasmic reticulum",1337.7,1338.7,1333.7,1179.5,1300.2,1231.3,1.0805982215036378,0.11183021262860891,0.04643537183508929,1.333151072452959,0.1820117385985829,0.7399006018820035,1992]
["High","O76031","ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial [OS=Homo sapiens]",39,20,48,20,633,69.2,7.58,90.67,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","CLPX","ENSG00000166855","","","",2439.5,2495.1,2344.4,2422.2,2394,2405.8,1.0078925505400167,0.011341844129704346,0.6929961473134286,0.15926917982566727,0.8378621737725691,0.07682741584817465,6458]
["High","O76039-1","Cyclin-dependent kinase-like 5 [OS=Homo sapiens]",3,2,2,1,1030,115.5,9.54,2.72,"","","","CDKL5","","","","",16.2,17,17.1,22.2,23.9,26.5,0.6928374655647385,-0.5294111481902233,0.004404035453862802,2.3561491934798044,0.052180134785676416,1.2824948034151789,659]
["High","O76041-2","Isoform 2 of Nebulette [OS=Homo sapiens]",10,3,3,2,270,31.2,8.31,7.4,"","","","NEBL","","","","",81.9,93.4,89.8,115.6,105.2,109.5,0.802603693611868,-0.31724029941826626,0.008749614851780555,2.0580110637122964,0.07499121049692928,1.1249896360266594,911]
["High","O76062","Delta(14)-sterol reductase [OS=Homo sapiens]",5,2,3,2,418,46.4,8.87,8.9,"other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","TM7SF2","ENSG00000149809","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Steroid biosynthesis; Metabolic pathways",225.1,218.6,243.2,207.7,215.2,209.1,1.086867088607595,0.12017552607757402,0.07656651430014859,1.1159611237650005,0.2416456522455781,0.6168210143994668,2474]
["High","O76064","E3 ubiquitin-protein ligase RNF8 [OS=Homo sapiens]",11,4,5,4,485,55.5,7.33,9.64,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","RNF8","ENSG00000112130","ATM signaling in development and disease ; 3q29 copy number variation syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome","Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Nonhomologous End-Joining (NHEJ)","",133.6,122.3,116.4,146.8,132,120.6,0.9321482223335001,-0.10136871659245991,0.37751806091664103,0.42306226636908445,0.6071392419437966,0.21671169595447276,4855]
["High","O76070","Gamma-synuclein [OS=Homo sapiens]",76,8,15,7,127,13.3,4.86,35.71,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","cytoskeleton;other cell component","other molecular function","SNCG","ENSG00000173267","","","",549.8,505.5,557.1,614.5,568.4,604.7,0.90199149697919,-0.14881426154393046,0.052265664287836536,1.2817835254229484,0.19322457706412297,0.7139376346260876,2112]
["High","O76071","Probable cytosolic iron-sulfur protein assembly protein Ciao1 [OS=Homo sapiens]",33,8,19,8,339,37.8,4.97,62.4,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","","CIAO1","ENSG00000144021","","Cytosolic iron-sulfur cluster assembly","",614.3,717.7,657.1,635,610.1,632.8,1.0592150806752225,0.08299556791153878,0.2983076612503695,0.525335592779292,0.5304455065003154,0.27535922522504447,4391]
["High","O76074","cGMP-specific 3',5'-cyclic phosphodiesterase [OS=Homo sapiens]",8,6,8,6,875,99.9,6.09,8.24,"other metabolic processes;signal transduction","cytosol","other molecular function","PDE5A","ENSG00000138735","Phosphodiesterases in neuronal function","cGMP effects; RHOBTB1 GTPase cycle","Purine metabolism; Metabolic pathways; cGMP-PKG signaling pathway",75.5,60.6,73.4,80.7,78.9,77.3,0.8843393837062049,-0.17732795465351772,0.12737738558857853,0.8949076692210118,0.3250204662338631,0.4880892910439565,3060]
["High","O76075","DNA fragmentation factor subunit beta [OS=Homo sapiens]",12,3,4,3,338,39.1,9,5.11,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DFFB","ENSG00000169598","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis","Apoptosis induced DNA fragmentation","Apoptosis",127.7,135.6,136.1,159.7,151.1,155.6,0.8563464837049742,-0.22373345575652392,0.003736779660966991,2.4275025095486407,0.04862795932138378,1.313113955273649,600]
["High","O76080","AN1-type zinc finger protein 5 [OS=Homo sapiens]",29,4,5,4,213,23.1,8.51,17.66,"developmental processes;signal transduction;other biological processes","other cell component","nucleic acid binding activity;other molecular function","ZFAND5","ENSG00000107372","","","",272.7,289.1,299.2,305.8,327.4,310.9,0.9119796631712742,-0.13292644173537366,0.05184218970608511,1.2853166630559465,0.19229635022570668,0.7160289585689982,2105]
["High","O76094","Signal recognition particle subunit SRP72 [OS=Homo sapiens]",36,20,56,20,671,74.6,9.26,128.38,"transport","cytosol;ER/Golgi;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","SRP72","ENSG00000174780","","SRP-dependent cotranslational protein targeting to membrane","Protein export",2294.8,2135.1,2422.8,2171,2504.1,2328.6,0.9784399674457784,-0.031444758419715266,0.7125298458968599,0.14719693954844765,0.8514589894035326,0.06983626502923083,6534]
["Medium","O76095-1","Protein JTB [OS=Homo sapiens]",9,1,2,1,146,16.3,8.28,2.18,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","other molecular function","JTB","ENSG00000143543; ENSGGOG00000005608; ENSPPAG00000028370; ENSPTRG00000001369","","","",41.6,39.5,41,45.2,36.3,43.3,0.9783653846153845,-0.03155473387484534,0.7621318743424697,0.1179698746657272,0.8791144445067223,0.0559545841043503,6769]
["High","O77932","Decapping and exoribonuclease protein [OS=Homo sapiens]",4,2,3,2,396,44.9,7.69,4.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","DXO","ENSG00000204348; ENSG00000206346; ENSG00000224313; ENSG00000225682; ENSG00000234798; ENSG00000236765","","","",70.4,78.2,66.8,87.4,81.7,103.5,0.7901687454145269,-0.3397673122610018,0.06027730028127972,1.2198462072399383,0.20871182288081244,0.6804529487952823,2255]
["High","O94760-1","N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [OS=Homo sapiens]",29,7,24,6,285,31.1,5.81,61.15,"other metabolic processes;signal transduction;other biological processes","cytosol","other molecular function","DDAH1","ENSG00000153904; ENSMFAG00000037521; ENSMMUG00000014573; ENSMNEG00000044101; ENSRBIG00000034663; ENSRROG00000009892","Mesodermal commitment pathway; Nitric oxide metabolism in cystic fibrosis","eNOS activation","",883.3,941.2,867.1,930.2,896.2,923,0.9789772313959408,-0.030652788208693153,0.47988678901123005,0.31886120576355054,0.6909378662363423,0.16056100554037014,5423]
["High","O94761","ATP-dependent DNA helicase Q4 [OS=Homo sapiens]",6,5,7,5,1208,133,8.09,14.84,"","","","","","","","",141.2,141.5,134,124.1,122,111.5,1.1652684563758389,0.22066236351923094,0.012862284836787197,1.8906818771451648,0.09264642066940446,1.0331713546888976,1084]
["High","O94762-1","ATP-dependent DNA helicase Q5 [OS=Homo sapiens]",9,8,9,8,991,108.8,8.56,13.93,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RECQL5","ENSG00000108469","","","",372,371.6,365,391.4,388.5,404.5,0.9360013508949678,-0.09541748289057948,9.575962802114037E-3,2.0188175496179355,0.07878726823910052,1.1035439573865926,949]
["High","O94763-1","Unconventional prefoldin RPB5 interactor 1 [OS=Homo sapiens]",19,9,15,9,535,59.8,5.05,26.66,"other biological processes","cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","URI1","ENSG00000105176","","","",477.1,531.5,522.5,553.2,584.9,564.1,0.8994830219715662,-0.15283204448185692,0.041328339345694666,1.3837520451777847,0.17137104280997553,0.7660625605358142,1883]
["High","O94766","Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 [OS=Homo sapiens]",26,8,12,8,335,37.1,8.27,26.73,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","B3GAT3","ENSG00000149541","Proteoglycan biosynthesis","A tetrasaccharide linker sequence is required for GAG synthesis; Defective B3GAT3 causes JDSSDHD","Glycosaminoglycan biosynthesis; Glycosaminoglycan biosynthesis; Metabolic pathways",526.9,492.4,535.8,443.8,464.7,448.4,1.1460682437909941,0.19669295338581258,0.010807432920109921,1.966277451377611,0.08430013610411415,1.0741717241982942,1001]
["High","O94768","Serine/threonine-protein kinase 17B [OS=Homo sapiens]",5,2,2,2,372,42.3,5.25,2.06,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus","kinase activity;other molecular function","STK17B","ENSG00000081320","","","",57.7,49,49.1,53.3,52,46.3,1.0277044854881268,0.039425479890577646,0.7169212946609502,0.14452851960504398,0.8526613052113785,0.0692234453719067,6565]
["High","O94776","Metastasis-associated protein MTA2 [OS=Homo sapiens]",34,22,66,20,668,75,9.66,131.78,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MTA2","ENSG00000149480","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","",2283.2,2206.5,2211.1,2215.4,2237.8,2241.8,1.0008663181478714,1.2492918317729852E-3,0.9446325119481179,0.024737111144797482,0.9725330502756995,0.01209563081617192,7584]
["High","O94782","Ubiquitin carboxyl-terminal hydrolase 1 [OS=Homo sapiens]",11,7,7,7,785,88.2,5.45,13.61,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus","other molecular function","USP1","ENSG00000162607","miR-517 relationship with ARCN1 and USP1; DNA repair pathways, full network","Fanconi Anemia Pathway; Recognition of DNA damage by PCNA-containing replication complex","Fanconi anemia pathway",305.1,336,341.7,383.8,364.4,376.6,0.8737553342816499,-0.1946987367103708,0.020357110250389988,1.6912838712950562,0.11678788893096623,0.9326021918397555,1361]
["High","O94788-1","retinal dehydrogenase 2 [OS=Homo sapiens]",5,5,11,2,518,56.7,6.05,23.03,"cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","ALDH1A2","ENSG00000128918","Ethanol effects on histone modifications; Tryptophan metabolism; 22q11.2 copy number variation syndrome; Vitamin A and carotenoid metabolism","RA biosynthesis pathway","Retinol metabolism; Metabolic pathways",393.3,435.4,411,438.5,410,423.4,0.9746835443037974,-0.0369942074822016,0.5063349822631412,0.2955620665317598,0.7104157307296688,0.1484874305438515,5565]
["High","O94804","Serine/threonine-protein kinase 10 [OS=Homo sapiens]",13,10,11,9,968,112.1,6.95,16.66,"cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","kinase activity;other molecular function","STK10","ENSG00000072786","","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation","Progesterone-mediated oocyte maturation",184.7,168,180.7,202.2,193.9,198.4,0.8972245584524811,-0.15645898508209205,0.021729123383419924,1.6629577940394775,0.120071475851198,0.9205601512294006,1413]
["High","O94808","Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [OS=Homo sapiens]",42,25,94,18,682,76.9,7.37,224.33,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","GFPT2","ENSG00000131459","","Synthesis of UDP-N-acetyl-glucosamine","Alanine, aspartate and glutamate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars; Insulin resistance; Diabetic cardiomyopathy",2352,2492.7,2677.1,1625.7,1771.2,1741.6,1.4638123966137977,0.5497306685004829,1.5819119646216374E-3,2.800817689196674,0.03250412794675196,1.4880614811548485,380]
["High","O94819","Kelch repeat and BTB domain-containing protein 11 [OS=Homo sapiens]",6,2,3,2,623,65.7,6.07,7.41,"","","","KBTBD11","ENSG00000176595; ENSG00000273645","","","",35,34.8,39.1,39.9,43.3,37.7,0.9007444168734493,-0.1508102905322164,0.13614171609363923,0.8660087793278604,0.3373514818340638,0.47191737784322463,3151]
["High","O94822","E3 ubiquitin-protein ligase listerin [OS=Homo sapiens]",18,25,40,25,1766,200.4,6.25,71.97,"protein metabolism;other metabolic processes","cytosol;other cell component","translation activity;other molecular function","LTN1","ENSG00000198862","","Antigen processing: Ubiquitination & Proteasome degradation","",1792.4,1868,1872,1981.7,1911.7,1931.2,0.949833464958967,-0.07425350811643452,0.04283610687840167,1.3681900065156458,0.174381815696851,0.7584988046916553,1918]
["High","O94826","Mitochondrial import receptor subunit TOM70 [OS=Homo sapiens]",48,25,95,25,608,67.4,7.12,193.99,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TOMM70","ENSG00000154174","Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation","Mitochondrial protein import; Ub-specific processing proteases; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PINK1-PRKN Mediated Mitophagy","",3540,3523.7,3534.8,3497.8,3403.8,3516,1.0173648441099679,0.024837146645084334,0.1609056209779263,0.7934287842598468,0.37082381599635433,0.43083238125988066,3388]
["High","O94829","Importin-13 [OS=Homo sapiens]",10,7,10,7,963,108.1,5.3,17.08,"transport","nucleus;other cell component","other molecular function","IPO13","ENSG00000117408","","","Nucleocytoplasmic transport",325.8,342.6,364.9,302.5,317.1,307,1.1151521692208075,0.15724058799419102,0.04261225109129905,1.3704655225771571,0.17401488311760616,0.7594136058586031,1912]
["High","O94830","Phospholipase DDHD2 [OS=Homo sapiens]",14,6,6,6,711,81,5.39,5.24,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","DDHD2","ENSG00000085788","","Synthesis of PA","",125.6,110.6,115.7,115.7,130.3,135.5,0.9224115334207077,-0.11651754297222823,0.2523925928628026,0.5979233947766158,0.48147602371677556,0.31742533476325,4093]
["High","O94832","Unconventional myosin-Id [OS=Homo sapiens]",8,7,8,7,1006,116.1,9.39,14.9,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1D","ENSG00000176658","","","Pathogenic Escherichia coli infection",370.3,323.1,395.1,264.6,300.5,308.5,1.2459935897435896,0.31729664615571646,0.046016985800250744,1.3370818318470834,0.1810078716011878,0.7423025382875817,1985]
["High","O94842","TOX high mobility group box family member 4 [OS=Homo sapiens]",9,4,7,4,621,66.2,5.06,12.49,"other biological processes","nucleus;other cell component","nucleic acid binding activity","TOX4","ENSG00000092203","","","",219.2,242.3,254.1,217.6,243,233.7,1.0306783811032696,0.04359421595125891,0.6046505070807909,0.21849557857676824,0.7812528809013429,0.10720836816658928,6043]
["High","O94854","Uncharacterized protein KIAA0754 [OS=Homo sapiens]",9,7,11,7,1291,135.1,4.21,28.81,"","","","KIAA0754","","","","",194.6,195.6,164.5,197.7,163.4,179.6,1.0258923617532827,0.03687936904335262,0.759270525538779,0.11960345886608192,0.8773692856899197,0.056817573132421556,6757]
["High","O94855","Protein transport protein Sec24D [OS=Homo sapiens]",18,15,33,15,1032,112.9,7.25,62.42,"cell organization and biogenesis;transport;developmental processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC24D","ENSG00000150961","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",1322,1308.7,1433.4,1348.2,1492.3,1417.2,0.9545294407778848,-0.06713839918666824,0.3237902524905187,0.48973622955824636,0.556494451121719,0.2545391617142371,4543]
["Low","O94856","Neurofascin [OS=Homo sapiens]",1,1,2,1,1347,149.9,6.65,0,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","NFASC","ENSG00000163531","","Neutrophil degranulation; Neurofascin interactions; Interaction between L1 and Ankyrins","Cell adhesion molecules",100,86,105.4,105,100,106.8,0.9345734445157151,-0.09762005063327227,0.32937852359952635,0.4823047214573578,0.5612805570198826,0.2508200016521011,4582]
["High","O94864-1","STAGA complex 65 subunit gamma [OS=Homo sapiens]",17,3,9,3,414,46.2,5.12,0,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SUPT7L","ENSG00000119760; ENSPTRG00000011777","","HATs acetylate histones","",57.6,56.8,52,55.7,54.3,53.9,1.0152532031726662,0.021839579041633257,0.6727622112371595,0.1721384106585435,0.8248943695571203,0.08360166072952067,6368]
["High","O94874-1","E3 UFM1-protein ligase 1 [OS=Homo sapiens]",16,11,28,11,794,89.5,6.79,48.52,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UFL1","ENSG00000014123","","Antigen processing: Ubiquitination & Proteasome degradation","",1527.1,1486.6,1488.8,1312.5,1415,1346.3,1.105233442977073,0.14435112206507467,0.01221639164211403,1.9130570527949087,0.09032725941441888,1.0441811663340668,1056]
["High","O94875-1","Sorbin and SH3 domain-containing protein 2 [OS=Homo sapiens]",1,1,1,1,1100,124,8.31,2.53,"cell organization and biogenesis;developmental processes;signal transduction","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SORBS2","ENSG00000154556","Extracellular vesicles in the crosstalk of cardiac cells","","",41.6,33.3,34.4,37.4,33,41.8,0.9741532976827096,-0.037779274936887916,0.8035402873611811,0.09499234399083176,0.9020909509297056,0.04474967366026155,6955]
["High","O94876","Transmembrane and coiled-coil domains protein 1 [OS=Homo sapiens]",15,7,9,6,653,72,6.55,15.21,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TMCC1","ENSG00000172765","","","",266.7,260.4,247.9,256.8,218,233.3,1.0944781810478745,0.13024319398181727,0.1505628618020332,0.8222821390481981,0.3580855391258834,0.4460132171189028,3283]
["High","O94880","PHD finger protein 14 [OS=Homo sapiens]",14,9,18,9,888,100,5.33,23.63,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF14","ENSG00000106443","","","",430.6,485,473.2,555.1,538.2,542.8,{"$f":"AVERAGE(T770:V770)/AVERAGE(W770:Y770)","v":0.8488478699346006},{"$f":"LOG(Z770,2)","v":-0.23642207698307552},{"$f":"TTEST(T770:V770,W770:Y770,2,2)","v":0.008827539325247736},{"$f":"-LOG10(AB770)","v":2.0541603390494814},{"$f":"AB770*7808/AF770","v":0.07508216454415502},{"$f":"-LOG10(AD770)","v":1.1244632155920886},918]
["High","O94885","SAM and SH3 domain-containing protein 1 [OS=Homo sapiens]",7,6,7,6,1247,136.6,6.09,16.32,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","SASH1","ENSG00000111961","","","",280.6,229.9,262.3,327.3,265,292.2,0.8737139626907857,-0.19476704874204767,0.1859323088396678,0.7306451377611525,0.4009277733830782,0.3969338579195287,3621]
["High","O94887-1","FERM, RhoGEF and pleckstrin domain-containing protein 2 [OS=Homo sapiens]",6,4,6,4,1054,119.8,8.79,7.26,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity","FARP2","ENSG00000006607","","RAC1 GTPase cycle; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Rap1 signaling pathway; Adherens junction",175.3,149.9,173,142.8,148.5,133.5,1.172787193973635,0.2299412554366833,0.05665656770515007,1.2467497388848419,0.20236710001912706,0.6938600918398905,2186]
["High","O94888","UBX domain-containing protein 7 [OS=Homo sapiens]",41,15,50,15,489,54.8,5.16,88.4,"","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","UBXN7","ENSG00000163960","3q29 copy number variation syndrome","Neddylation","",1757.6,1903.6,1718.6,2011.9,1839.6,1967.7,0.9244913390156722,-0.1132682909070729,0.12776015522573392,0.8936045692111614,0.32535919504322586,0.48763691507088225,3066]
["High","O94889","Kelch-like protein 18 [OS=Homo sapiens]",8,4,7,3,574,63.6,5.6,13.5,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","","","KLHL18","ENSG00000114648","","","",59,72.3,60.7,53.9,53,57.9,1.1650485436893203,0.2203900684253001,0.11080048965170994,0.9554583203606053,0.30101956270026137,0.5214052795001768,2874]
["High","O94898","Leucine-rich repeats and immunoglobulin-like domains protein 2 [OS=Homo sapiens]",2,1,1,1,1065,118.9,5.55,3.51,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","LRIG2","ENSG00000198799","","","Axon guidance",47,59.8,54.3,47.7,51.9,60.7,1.0049906425452275,0.007182068552020484,0.9624997583001766,0.016599370878072353,0.9799449879785864,0.008798303989068732,7669]
["High","O94901-1","SUN domain-containing protein 1 [OS=Homo sapiens]",28,15,51,14,812,90,7.08,133.9,"","","","","","","","",1928.8,2018.6,1955.6,1698.3,1756.3,1761.3,1.1317318200118869,0.17853213151232095,2.3742547545153275E-3,2.624472683635703,0.04003926808478548,1.3975138699950207,463]
["High","O94903","Pyridoxal phosphate homeostasis protein [OS=Homo sapiens]",42,11,47,11,275,30.3,7.5,93.29,"","cytosol;other cell component","other molecular function","PLPBP","ENSG00000147471","","","",2412.2,2456.7,2365.2,2115.7,2138,2148,1.1300279613227735,0.17635847101446053,0.000589335069576805,3.2296377145632276,0.021705321807809874,1.6634337708333438,212]
["High","O94905-1","Erlin-2 [OS=Homo sapiens]",52,18,80,15,339,37.8,5.62,160.07,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ERLIN2","ENSG00000147475; ENSGGOG00000012855; ENSPPAG00000034728; ENSPTRG00000020158","","ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions","",3744.1,3514.1,3660.8,3332.9,3695.8,3558.8,1.031310507674144,0.04447876572021934,0.427837909482886,0.36872073647837755,0.650800389098456,0.18655219608050486,5133]
["High","O94906-1","Pre-mRNA-processing factor 6 [OS=Homo sapiens]",48,43,144,43,941,106.9,8.25,301.32,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PRPF6","ENSG00000101161; ENSGGOG00000016876; ENSPPAG00000008686; ENSPTRG00000013765","mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",6022.6,5645.2,6003.1,5843.1,5738.8,5869.5,1.0125777874554476,0.01803274183976262,0.6009191566623666,0.22118395092078433,0.7791392851577148,0.10838489743888945,6022]
["High","O94913","Pre-mRNA cleavage complex 2 protein Pcf11 [OS=Homo sapiens]",10,12,21,12,1555,172.9,8.48,42.05,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCF11","ENSG00000165494","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",816.1,793.3,795.3,858.9,815.9,786.3,0.9770834179838283,-0.033446358103962695,0.44668997148441003,0.34999379764652316,0.664460906334592,0.17753056575602838,5249]
["High","O94915-1","protein furry homolog-like [OS=Homo sapiens]",4,9,9,9,3013,339.4,5.58,17.4,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","","FRYL","ENSG00000075539","","","",364.8,364.3,388.7,361.3,360.6,395,1.0008058017727637,1.1620580901244631E-3,0.983834445114351,0.007077976388176571,0.990686013341869,0.004063968400732412,7754]
["High","O94916","nuclear factor of activated T-cells 5 [OS=Homo sapiens]",2,4,5,4,1531,165.7,5.24,8.46,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFAT5","ENSG00000102908","Cancer immunotherapy by PD-1 blockade","","",377.6,353.2,363.3,384.6,382,405.2,0.9336917562724015,-0.0989817495506792,0.06396506063657735,1.1940571840815606,0.21546125688110265,0.6666308110505025,2318]
["High","O94919","endonuclease domain-containing 1 protein [OS=Homo sapiens]",21,6,10,6,500,55,5.71,10.9,"other metabolic processes","non-structural extracellular;cytosol","nucleic acid binding activity;other molecular function","ENDOD1","ENSG00000149218","","Platelet degranulation","",149,155.1,126.8,138.4,131.8,140.9,1.0481634638774022,0.06786372654644536,0.5047803551055681,0.29689755518084704,0.709764994176891,0.1488854239947782,5553]
["High","O94921-1","Cyclin-dependent kinase 14 [OS=Homo sapiens]",4,2,3,1,469,53,8.92,4.72,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CDK14","ENSCATG00000032271; ENSCSAG00000012501; ENSG00000058091; ENSGGOG00000003585; ENSMLEG00000038830; ENSMNEG00000032203; ENSPANG00000022338","","","Transcriptional misregulation in cancer",23.4,14.2,19.4,26.2,16.7,21.9,0.8796296296296295,-0.18503189383252086,0.534053148399565,0.2724155202971662,0.7319443536429354,0.1355219350952108,5697]
["High","O94923","D-glucuronyl C5-epimerase [OS=Homo sapiens]",2,1,2,1,617,70.1,8.97,0,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GLCE","ENSG00000138604","","HS-GAG biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",36.6,33.9,38,24.2,29,24.9,1.3892445582586428,0.4743005891898624,6.186913365228865E-3,2.208525965322568,0.06298229407523726,1.2007815246129137,767]
["High","O94925-1","Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",27,17,56,1,669,73.4,7.77,116.85,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","GLS","ENSG00000115419; ENSGGOG00000007590; ENSPTRG00000012747","Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling","Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer",64.3,65.8,64.8,40.8,38.3,39.9,1.63781512605042,0.7117725170625839,7.72150652133743e-06,5.112297957426855,0.007536190364825332,2.1228481397601633,8]
["High","O94925-3","Isoform 3 of Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",36,19,69,3,598,65.4,7.88,154.85,"","","","GLS","","","","",2859.4,3133,3001.6,2717.2,2686.9,2851.2,1.0894819085920562,0.12364223995888894,0.05840533648822448,1.2335474696426405,0.20523351363638917,0.687751719588854,2222]
["High","O94927","HAUS augmin-like complex subunit 5 [OS=Homo sapiens]",8,4,6,4,633,71.6,8.51,17.88,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","","HAUS5","ENSG00000249115","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",209.7,204.7,205.1,208.5,209.5,215.6,0.977746212121212,-0.03246805305164584,0.1611942532369694,0.7926504453594724,0.3710509225454767,0.43056648428551325,3392]
["High","O94941-1","RING finger protein 37 [OS=Homo sapiens]",3,1,4,1,541,58.9,7.56,12.27,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","UBOX5","ENSG00000185019","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",76.9,89.7,80.2,68.9,62.4,73.4,1.205666829506595,0.26983129212600737,0.048247228154978436,1.3165276321974215,0.18575658650595248,0.7310557782000844,2028]
["High","O94952-1","Isoform 2 of F-box only protein 21 [OS=Homo sapiens]",12,6,7,6,621,71.4,6.01,18.46,"","","","FBXO21","","","","",423.7,410.2,496.7,276.4,355.3,303,1.4235583609714346,0.5095016398017465,0.020487888785336805,1.6885027920194016,0.11702226454711762,0.9317315019285883,1367]
["High","O94953","lysine-specific demethylase 4B [OS=Homo sapiens]",17,12,19,12,1096,121.8,7.09,55.62,"cell organization and biogenesis;protein metabolism;other metabolic processes","nucleus","other molecular function","KDM4B","ENSG00000127663","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Estrogen-dependent gene expression; HDMs demethylate histones","",950.9,1124.5,988,957.2,877,965.8,1.0940714285714286,0.12970693034418687,0.21644859657679702,0.6646452257479314,0.44149180827367585,0.35507735019410197,3828]
["High","O94964-2","Isoform 2 of Protein SOGA1 [OS=Homo sapiens]",11,17,21,14,1661,183.7,6.52,48.57,"","","","SOGA1","","","","",791.4,778.9,789.5,917.5,873.1,877.1,0.8845822243880498,-0.17693184320570512,0.002215808256174927,2.654467823766744,0.03914260376518966,1.4073502884572004,442]
["High","O94966-6","Isoform 6 of Ubiquitin carboxyl-terminal hydrolase 19 [OS=Homo sapiens]",18,15,26,15,1384,151.8,6.42,56.32,"","","","USP19","","","","",759.6,683.7,710.4,770.9,721.1,705.1,0.9802466888170772,-0.028783231428078978,0.6524980359126414,0.18542079125954442,0.8128118481821801,0.09000997439746149,6268]
["High","O94967-1","WD repeat-containing protein 47 [OS=Homo sapiens]",3,3,4,3,919,101.9,5.94,7.7,"","cytoskeleton;other cell component","","WDR47","ENSG00000085433","","","",237.1,284.4,273.6,196.9,226.1,212.3,1.251534708011963,0.3236983009202995,0.03268876473653816,1.4856014905007335,0.15031441405352766,0.822999371750032,1698]
["High","O94973","AP-2 complex subunit alpha-2 [OS=Homo sapiens]",28,21,51,12,939,103.9,6.96,100.25,"transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","AP2A2","ENSG00000183020","Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission","Neutrophil degranulation; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; Potential therapeutics for SARS; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease",954.9,940.7,1074.1,891.6,963.9,937.4,1.063303376418776,0.08855327815844675,0.2805800412974527,0.5519432251917176,0.5109069408699884,0.2916581972177958,4288]
["High","O94979","Protein transport protein Sec31A [OS=Homo sapiens]",21,23,58,23,1220,132.9,6.89,119.61,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC31A","ENSG00000138674","Sterol regulatory element-binding proteins (SREBP) signaling","COPII-mediated vesicle transport; Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; XBP1(S) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum",2441.6,2388.1,2633.5,2404.2,2639.6,2585.2,0.9782671385502688,-0.031699614540346095,0.6200883424157255,0.20754643325893976,0.7903443972546499,0.10218362107085821,6126]
["Low","O94983","Calmodulin-binding transcription activator 2 [OS=Homo sapiens]",1,1,1,1,1202,131.4,7.3,0,"stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CAMTA2","ENSG00000108509","","","",32.9,26.9,26.1,27.3,30.1,25.8,1.0324519230769231,0.046074602997371455,0.7358903105485292,0.13318691538215968,0.8648151030648579,0.06307673450288116,6644]
["High","O94985-1","Calsyntenin-1 [OS=Homo sapiens]",1,1,2,1,981,109.7,4.91,2.37,"cell adhesion;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CLSTN1","ENSG00000171603","Splicing factor NOVA regulated synaptic proteins","","",43.1,39.6,43.4,42.7,42.5,41.3,0.9968379446640316,-0.00456910925345261,0.9229925836719057,0.034801788555135924,0.9615378376664763,0.01703362108079881,7495]
["High","O94986-1","Isoform 1 of Centrosomal protein of 152 kDa [OS=Homo sapiens]",5,4,4,4,1275,147.3,5.43,4.51,"","","","CEP152","","","","",49.5,31.9,41.9,38.7,39.1,40.5,1.0422654268808114,0.05972272606305047,0.7613501851810164,0.11841554229542059,0.8786021646310045,0.05620773108874693,6766]
["High","O94992","Protein HEXIM1 [OS=Homo sapiens]",13,4,5,4,359,40.6,4.89,3.94,"stress response;developmental processes;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","HEXIM1","ENSG00000186834","Initiation of transcription and translation elongation at the HIV-1 LTR","","",234.6,237.7,250.3,400.8,219.9,171.1,0.9126041929780246,-0.1319388125976535,0.7584021117106771,0.12010046640968211,0.8768848938600572,0.057057411471229155,6753]
["High","O95049-1","Tight junction protein ZO-3 [OS=Homo sapiens]",3,2,2,2,919,101.3,6.76,5.46,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","TJP3","ENSG00000105289","1q21.1 copy number variation syndrome","","Tight junction",75.2,75.7,84.3,89.8,80.4,89.3,0.90635838150289,-0.14184647840887896,0.12923380925618372,0.888623854355059,0.32750976393128284,0.4847757480133642,3081]
["High","O95057","GTP-binding protein Di-Ras1 [OS=Homo sapiens]",11,2,2,2,198,22.3,8.72,5.66,"signal transduction","plasma membrane;other membranes","other molecular function","DIRAS1","ENSG00000176490","","","",74,83.8,70.7,103.7,92.6,92.4,0.7914790439903012,-0.3373769422905501,0.020837762185668095,1.6811489227333425,0.1181563160099466,0.9275430583316308,1377]
["High","O95059","Ribonuclease P protein subunit p14 [OS=Homo sapiens]",16,1,2,1,124,13.7,7.75,3.51,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP14","ENSG00000163684","","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","",15.4,14.1,23.4,10.9,18,14.8,1.2105263157894735,0.27563444261342707,0.4375033305882955,0.3590186364688394,0.6574337962342978,0.1821479742111943,5196]
["High","O95067","G2/mitotic-specific cyclin-B2 [OS=Homo sapiens]",26,8,14,8,398,45.3,8.9,33.23,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","CCNB2","ENSG00000157456","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response","Resolution of Sister Chromatid Cohesion; Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint","FoxO signaling pathway; Cell cycle; Oocyte meiosis; p53 signaling pathway; Cellular senescence; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection",822.7,751.6,854.5,657.5,732.3,703.8,1.1601069927397785,0.21425786636743166,0.04050375198590034,1.3925047449014023,0.1691194093614491,0.771806546779266,1870]
["High","O95071","E3 ubiquitin-protein ligase UBR5 [OS=Homo sapiens]",18,35,63,35,2799,309.2,5.85,149.28,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBR5","ENSG00000104517","Mesodermal commitment pathway","","Ubiquitin mediated proteolysis",2155,2125.4,2270.5,2257.1,2340.5,2335.7,0.9448458886821571,-0.08184906054338759,0.06988087778862245,1.1556416483891536,0.2275354019072411,0.6429510224933481,2398]
["High","O95104","Splicing factor, arginine/serine-rich 15 [OS=Homo sapiens]",20,22,77,19,1147,125.8,9.55,162.91,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SCAF4","ENSG00000156304","","","",3371.7,3224.6,3340.5,3268.7,3307.3,3292.8,1.006890402075227,0.009906657537776897,0.6490012934493038,0.18775443765674096,0.8098772733342119,0.09158078797562685,6257]
["High","O95125","Zinc finger protein 202 [OS=Homo sapiens]",3,2,4,1,648,74.7,5.97,8.5,"other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF202","ENSG00000166261","","Generic Transcription Pathway","",79.2,84.5,79.7,84.8,93.5,89.5,0.9088872292755787,-0.13782679261058223,0.054939612033639236,1.2601144117564573,0.19850462321085385,0.7022293739810631,2161]
["High","O95139","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [OS=Homo sapiens]",20,2,4,2,128,15.5,9.63,9.65,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB6","ENSG00000165264","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",57.6,71.2,48.7,53.6,40.1,58.7,1.1646981627296586,0.21995612178608456,0.38463513465082827,0.4149510474817117,0.6134050513385758,0.21225265196058105,4896]
["High","O95140","Mitofusin-2 [OS=Homo sapiens]",17,11,15,11,757,86.3,6.98,31.41,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion","other molecular function","MFN2","ENSG00000116688","Intracellular trafficking proteins involved in CMT neuropathy","Factors involved in megakaryocyte development and platelet production; PINK1-PRKN Mediated Mitophagy; RHOT2 GTPase cycle","Mitophagy; NOD-like receptor signaling pathway; Parkinson disease; Pathways of neurodegeneration",615.1,552.4,624.7,492.6,553.4,520.6,1.144006127920337,0.19409477999794866,0.05868185629409428,1.2314961564931923,0.20555761953534685,0.6870664203147948,2229]
["High","O95149","Snurportin-1 [OS=Homo sapiens]",8,3,5,3,360,41.1,6.64,11.4,"transport","cytosol;nucleus","nucleic acid binding activity;other molecular function","SNUPN","ENSG00000169371","","snRNP Assembly","Nucleocytoplasmic transport",399.1,380,392.9,419.4,466.9,440.7,0.8831951770911832,-0.17919580094794532,0.025335580151266735,1.596269146490379,0.12912546332969363,0.888988107128329,1532]
["High","O95155","Ubiquitin conjugation factor E4 B [OS=Homo sapiens]",26,26,68,24,1302,146.1,6.55,144.91,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","UBE4B","ENSG00000130939","","","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",2466.9,2537.5,2639.5,2469,2533.5,2471.8,1.0226910881286542,0.03237043352264862,0.3569321607388769,0.4474143189477776,0.5904504896290574,0.22881651292322994,4720]
["High","O95159","Zinc finger protein-like 1 [OS=Homo sapiens]",19,4,10,4,310,34.1,8.07,28.64,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","ZFPL1","ENSG00000162300","","","",858,833.1,762.8,750.2,733.5,744.8,1.1011442674444691,0.1390034973234186,0.06021083894919272,1.2203253214979402,0.2086667689814899,0.6805467085631357,2253]
["High","O95163","Elongator complex protein 1 [OS=Homo sapiens]",27,25,68,25,1332,150.2,5.94,159.43,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","ELP1","ENSG00000070061","","HATs acetylate histones","",2126.7,2197.2,2235.9,2154.8,2329.8,2274.4,0.9705281846426986,-0.04315798472655389,0.33567765062447696,0.4740775730611195,0.5676783833822647,0.2458976429536252,4617]
["High","O95166","Gamma-aminobutyric acid receptor-associated protein [OS=Homo sapiens]",12,2,4,1,117,13.9,8.79,3.78,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAP","ENSG00000170296","","Macroautophagy; TBC/RABGAPs","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse",195.8,142.3,180.2,273.4,210.9,213.7,0.7425501432664756,-0.4294396427123154,0.08131787675406461,1.0898139695080737,0.25046547601409724,0.6012521285187932,2535]
["High","O95169","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [OS=Homo sapiens]",18,3,8,3,186,21.8,6.8,10.96,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;ER/Golgi","transporter activity","NDUFB8","ENSG00000166136","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Mitochondrial protein import; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",405.9,404.4,378.6,413.8,405.8,419.7,0.9593318809005085,-0.05989809288813632,0.15941412319655404,0.7974732051819403,0.3693488053171199,0.43256330139464355,3370]
["Low","O95183","vesicle-associated membrane protein 5 [OS=Homo sapiens]",6,1,1,1,116,12.8,7.85,2.25,"transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP5","ENSG00000168899","","","SNARE interactions in vesicular transport",135.8,105.2,101.4,116.2,112.7,125.5,0.9661399548532731,-0.04969590215387143,0.7463253002985278,0.12707183562227237,0.8711777462596659,0.0598932269162703,6689]
["High","O95197","Reticulon-3 [OS=Homo sapiens]",4,4,12,3,1032,112.5,4.96,24.88,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","RTN3","ENSG00000133318","Alzheimer's disease and miRNA effects; Alzheimer's disease","Synaptic adhesion-like molecules","Alzheimer disease",794.6,849.4,916.3,715.8,819.4,833.5,1.080888250939334,0.11221737584839905,0.279811559893755,0.5531343474054365,0.5099833472573387,0.2924440049066191,4284]
["High","O95202-1","mitochondrial proton/calcium exchanger protein [OS=Homo sapiens]",41,30,98,30,739,83.3,6.7,215.37,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;translation activity;other molecular function","LETM1","ENSG00000168924","","RHOG GTPase cycle; Mitochondrial calcium ion transport","",4413.9,3947.6,4342.1,4553.5,4254,4415.7,0.9607054268255794,-0.05783395775430773,0.36292865558841575,0.44017874005900226,0.5960763447274611,0.22469811279252838,4754]
["High","O95208-1","epsin-2 [OS=Homo sapiens]",7,4,5,4,641,68.4,7.52,11.18,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","EPN2","ENSG00000072134","","Cargo recognition for clathrin-mediated endocytosis","Endocytosis",232.7,269.6,220,215.4,215.3,201.5,1.1425181904460613,0.19221713513665686,0.126069691067405,0.8993893113994587,0.32295017974222384,0.49086446940838613,3048]
["High","O95210","Starch-binding domain-containing protein 1 [OS=Homo sapiens]",4,2,2,2,358,39,5.73,4.4,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STBD1","ENSG00000118804","Exercise-induced circadian regulation","Neutrophil degranulation; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","",158.9,151.9,170.3,159.3,159.7,147,1.0324034334763947,0.04600684454057899,0.4997734035303002,0.3012268594688133,0.7056475108073388,0.1514121861148762,5530]
["High","O95218-1","Zinc finger Ran-binding domain-containing protein 2 [OS=Homo sapiens]",42,19,63,19,330,37.4,10.01,123.1,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRANB2","ENSANAG00000018241; ENSCANG00000036472; ENSCATG00000025001; ENSG00000132485; ENSGGOG00000023501; ENSMFAG00000003326; ENSMLEG00000036639; ENSMNEG00000042080; ENSNLEG00000009455; ENSPANG00000013398; ENSPPAG00000037049; ENSPTRG00000000856; ENSSBOG00000013268","","","",2884.9,3000.2,2951.1,3516.6,3316.7,3410,0.8626321595579551,-0.21318259308584878,0.00215679193155495,2.6661917498145242,0.0387131756358185,1.4121412021105264,435]
["High","O95219","sorting nexin-4 [OS=Homo sapiens]",26,9,22,9,450,51.9,5.99,41.35,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX4","ENSG00000114520","","","Endocytosis",764.3,722.2,736.9,788.6,781,754.3,0.9567537329489222,-0.06378047004518096,0.10648440584372142,0.9727139880176866,0.29265407984082253,0.533645417081987,2841]
["High","O95229","ZW10 interactor [OS=Homo sapiens]",12,3,4,3,277,31.3,5.15,8.19,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","ZWINT","ENSG00000122952","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",171,176.1,158.2,169.8,138.3,148.9,1.1056892778993435,0.1449460146725206,0.20603828204438795,0.6860520799414924,0.4280859250139918,0.3684690510473638,3758]
["High","O95232-1","Luc7-like protein 3 [OS=Homo sapiens]",50,23,92,23,432,51.4,9.79,185.6,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","LUC7L3","ENSCANG00000028098; ENSCATG00000034891; ENSG00000108848; ENSGGOG00000024399; ENSMLEG00000034172; ENSMMUG00000010117; ENSPPAG00000025115; ENSPTRG00000009409; ENSRROG00000039925","","","",5522.5,5656.6,5462.5,5538.8,5307.7,5487.4,1.018838121942708,0.026924847163636804,0.3206477640938174,0.49397178411132253,0.5535303431449317,0.25685856719860584,4523]
["High","O95235","kinesin-like protein KIF20A [OS=Homo sapiens]",20,15,33,15,890,100.2,6.92,63.4,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF20A","ENSG00000112984","","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Mitotic Telophase/Cytokinesis","",1118.6,1131.1,1160.1,971.8,978.6,949,1.1760364213285506,0.23393274049436952,3.6326074149389224E-4,3.4397815349031595,0.01750827079990315,1.756756744787155,162]
["High","O95237","lecithin retinol acyltransferase [OS=Homo sapiens]",23,4,9,4,230,25.7,7.46,16.73,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LRAT","ENSG00000121207","Vitamin A and carotenoid metabolism","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events","Retinol metabolism; Metabolic pathways; Vitamin digestion and absorption",383.3,437.7,391.3,293.6,299.7,306.4,1.3474491497165721,0.430230829314719,0.003873943270909234,2.4118467432739736,0.04926343494993372,1.307475309756506,614]
["High","O95239-1","Chromosome-associated kinesin KIF4A [OS=Homo sapiens]",48,55,162,55,1232,139.8,6.27,329.66,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","KIF4A","ENSG00000090889; ENSGGOG00000006631; ENSPTRG00000021996","Retinoblastoma gene in cancer","MHC class II antigen presentation; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",7556.2,7067.7,7164.7,6658,6389.5,6713.3,1.1026173029432005,0.14093214636977808,0.01975290736962611,1.7043689728649745,0.11622509475662447,0.9347000910707746,1327]
["High","O95243-2","Isoform 2 of Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",9,5,6,5,574,65.3,8.84,2.68,"","","","MBD4","","","","",215.4,202.4,214.7,212.8,211.7,205.5,1.003968253968254,5.7136511943936385E-3,0.8704485310696551,0.06025690327528077,0.9344785000126312,0.029430686188079647,7273]
["High","O95248-1","Myotubularin-related protein 5 [OS=Homo sapiens]",4,6,7,6,1867,208.2,6.9,14.6,"","","","","","","","",268.9,291.1,278.4,252.5,268.1,233.1,1.1123789306089955,0.15364832420052368,0.07816499989637463,1.106987668353313,0.2446141559883339,0.6115184136540865,2495]
["High","O95249-1","Golgi SNAP receptor complex member 1 [OS=Homo sapiens]",27,8,14,8,250,28.6,9.42,28.62,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","GOSR1","ENSG00000108587","","Intra-Golgi traffic; COPI-mediated anterograde transport","SNARE interactions in vesicular transport",592.7,603.1,611.3,700,635.7,618.8,0.9245842926579688,-0.1131232413952089,0.12424728316081557,0.9057130989420434,0.320807799907291,0.49375508111257693,3024]
["High","O95251-1","Histone acetyltransferase KAT7 [OS=Homo sapiens]",17,11,25,11,611,70.6,8.85,39.46,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KAT7","ENSAMEG00000012243; ENSANAG00000032052; ENSCANG00000040077; ENSCATG00000030056; ENSCJAG00000007037; ENSDLEG00000005028; ENSECAG00000010150; ENSG00000136504; ENSGGOG00000007469; ENSMLEG00000043692; ENSMNEG00000044419; ENSPANG00000022824; ENSPCTG00005022544; ENSPPAG00000041097; ENSPPYG00000008925; ENSPTRG00000009383; ENSRFEG00010021504","Androgen receptor signaling pathway; Androgen receptor signaling pathway","HATs acetylate histones","",902.3,977.9,965.5,976.4,1062.2,1064.2,0.9171393579992264,-0.12478712898534575,0.08271707450763224,1.0824048338688408,0.25278078972821627,0.5972559336809368,2555]
["Low","O95259","Potassium voltage-gated channel subfamily H member 1 [OS=Homo sapiens]",1,1,1,1,989,111.4,7.58,1.63,"transport;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","KCNH1","ENSG00000143473","","Voltage gated Potassium channels","",67,47.1,68.7,43.8,67.7,58,1.0784660766961653,0.10898079703436367,0.6747613753360582,0.1708497852389707,0.8257894700037527,0.08313065930149764,6380]
["High","O95260-2","Isoform ATE1-2 of Arginyl-tRNA--protein transferase 1 [OS=Homo sapiens]",22,7,9,7,518,59,7.02,16.14,"","","","ATE1","","","","",204.5,210.2,241.2,242.3,241.5,231.2,0.9173426573426573,-0.12446736683632324,0.17457978966875182,0.7580060340747206,0.38713973238671234,0.41213225448626944,3521]
["High","O95271","Tankyrase-1 [OS=Homo sapiens]",1,2,3,2,1327,142,7.05,4.3,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","TNKS","ENSG00000173273","NAD+ biosynthetic pathways; Regulation of Wnt / B-catenin signaling by small molecule compounds","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; XAV939 stabilizes AXIN","",67.8,83,71.8,77.1,92.4,77.3,{"$f":"AVERAGE(T834:V834)/AVERAGE(W834:Y834)","v":0.9019448946515397},{"$f":"LOG(Z834,2)","v":-0.14888880180745842},{"$f":"TTEST(T834:V834,W834:Y834,2,2)","v":0.30173799093537124},{"$f":"-LOG10(AB834)","v":0.5203700056524413},{"$f":"AB834*7808/AF834","v":0.5344760057221821},{"$f":"-LOG10(AD834)","v":0.2720717868375345},4408]
["High","O95273-1","Cyclin-D1-binding protein 1 [OS=Homo sapiens]",9,4,10,4,360,40.2,4.82,21.8,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","","CCNDBP1","ENSG00000166946","","","",729.9,774.6,786.2,670.2,635.1,635.8,1.1801040647055792,0.23891408587091748,0.004903804006909892,2.309466895834359,0.05557170056016319,1.2551463130833496,689]
["High","O95292","Vesicle-associated membrane protein-associated protein B/C [OS=Homo sapiens]",48,11,35,10,243,27.2,7.3,61.69,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAPB","ENSG00000124164","Ciliary landscape","RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle; Sphingolipid de novo biosynthesis","Cholesterol metabolism; Amyotrophic lateral sclerosis; Pathways of neurodegeneration",2051.5,2087.6,1964.4,2107.3,2035.8,1891.1,1.0114845381326438,0.016474266579487237,0.7685793901049889,0.11431126556993286,0.8822504966097844,0.05440808850800077,6802]
["Medium","O95294-1","RasGAP-activating-like protein 1 [OS=Homo sapiens]",1,1,1,1,804,90,6.51,0,"signal transduction;other biological processes","cytosol","enzyme regulator activity;other molecular function","RASAL1","ENSG00000111344","Ras signaling","Regulation of RAS by GAPs","Ras signaling pathway",9.3,13.9,8.6,15.3,15.1,16.3,0.6809421841541756,-0.5543957844253066,0.04341810096833056,1.3623291757459712,0.17583430101697356,0.7548964006541478,1928]
["High","O95295","SNARE-associated protein Snapin [OS=Homo sapiens]",14,2,4,2,136,14.9,9.31,7.34,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SNAPIN","ENSG00000143553","","Golgi Associated Vesicle Biogenesis","",107,97.1,74.5,86.7,72.1,77.8,1.1775147928994083,0.23574518426146457,0.25382822883667383,0.5954600806405984,0.48256411267512767,0.3164449788356154,4107]
["High","O95297-1","Myelin protein zero-like protein 1 [OS=Homo sapiens]",13,3,6,3,269,29.1,8.72,11.85,"cell-cell signaling;signal transduction","plasma membrane;other membranes","other molecular function","MPZL1","ENSG00000197965","","","Cell adhesion molecules",180.3,163.8,158.6,224.5,192.4,215.4,0.7950340028467502,-0.3309115304786284,0.020268585986447894,1.693176548282987,0.11662278510109443,0.9332165912840886,1357]
["High","O95298-1","NADH dehydrogenase [ubiquinone] 1 subunit C2 [OS=Homo sapiens]",24,4,14,4,119,14.2,8.98,25.51,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","NDUFC2","ENSG00000151366; ENSGGOG00000041901","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Neutrophil degranulation; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",1014.2,1015.5,899.3,826.7,979.9,968.8,1.0553433739280826,0.07771248069898926,0.459204651259501,0.3379937216420846,0.6739605107207112,0.1713655492784974,5320]
["High","O95299","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [OS=Homo sapiens]",22,7,18,7,355,40.7,8.48,37.43,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity","NDUFA10","ENSG00000130414","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",866.3,870.6,955.4,883.9,964.7,927.4,0.9698487031700288,-0.04416839110401927,0.49537659694992714,0.3050645146165259,0.7029989947264688,0.15304529601155523,5502]
["High","O95302","Peptidyl-prolyl cis-trans isomerase FKBP9 [OS=Homo sapiens]",7,5,8,4,570,63,5.08,9.64,"protein metabolism;other metabolic processes;other biological processes","ER/Golgi","other molecular function","FKBP9","ENSG00000122642","","Association of TriC/CCT with target proteins during biosynthesis","",265.6,273.5,259.5,293.1,258,268.5,0.9743777452415813,-0.03744691237819867,0.5646271948657675,0.2482382082016565,0.7538661315854844,0.12270576749282514,5848]
["High","O95336","6-phosphogluconolactonase [OS=Homo sapiens]",52,10,57,10,258,27.5,6.05,133.7,"other metabolic processes","cytosol;other cell component","other molecular function","PGLS","ENSG00000130313","Pentose phosphate metabolism","Pentose phosphate pathway","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism",2152.1,2090.4,2139.2,2114.8,2231.7,2194.6,0.9756310100747579,-0.035592480490379476,0.24751039112531575,0.6064065635439301,0.4769400626620102,0.32153619557353746,4052]
["High","O95340","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [OS=Homo sapiens]",16,9,11,8,614,69.5,8.03,20.58,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS2","ENSG00000198682","RANKL/RANK signaling pathway; Proteoglycan biosynthesis; Sulfation biotransformation reaction","Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Defective PAPSS2 causes SEMD-PA","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways",492.7,495.3,503.8,503.3,510.2,512.7,0.9774603590617219,-0.03288989982770097,0.05871927396750119,1.231219322878383,0.2055964534252239,0.6869843812679083,2230]
["High","O95347-1","structural maintenance of chromosomes protein 2 [OS=Homo sapiens]",51,64,194,64,1197,135.6,8.43,396.49,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC2; SMC2L1","ENSG00000136824","Retinoblastoma gene in cancer","Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes","",8867.3,8351.3,8575.4,9143.2,9029.4,9191.8,0.9426115683150372,-0.08526470777521405,0.028960605075264656,1.5381923686453531,0.1394968565253957,0.8554355788352326,1621]
["High","O95352","Ubiquitin-like modifier-activating enzyme ATG7 [OS=Homo sapiens]",6,4,5,4,703,77.9,6.24,8.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","other molecular function","ATG7","ENSG00000197548","Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy","Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Macroautophagy","Autophagy; Autophagy; Ferroptosis; Neutrophil extracellular trap formation",328.8,322.6,329.1,342.9,338.6,327.7,0.9715616329766151,-0.04162257589678913,0.12797590832955433,0.8928717792919718,0.32569618391041727,0.48718732991027974,3068]
["High","O95359-3","Isoform 3 of Transforming acidic coiled-coil-containing protein 2 [OS=Homo sapiens]",8,15,28,12,2871,300.9,4.78,64.6,"","","","TACC2","","","","",470.6,495.5,466.8,559.7,498.1,494.1,0.9233198015336039,-0.11509766784389655,0.16052711761344524,0.7944515923239855,0.3704982956919245,0.43121378545333067,3383]
["High","O95363","phenylalanine--tRNA ligase, mitochondrial [OS=Homo sapiens]",8,4,5,4,451,52.3,7.46,10.62,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","FARS2","ENSG00000145982","","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",197.9,184.8,237.6,196.3,228.2,197.8,0.9967861160212118,-0.004644121315619754,0.9736535677950953,0.011595540408805794,0.9851350339956076,0.006504236000124065,7717]
["High","O95365","Zinc finger and BTB domain-containing protein 7A [OS=Homo sapiens]",4,1,2,1,584,61.4,5.19,7.63,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB7A","ENSG00000178951","IL-18 signaling pathway","","",16.8,23.5,21.4,13.4,13.8,14.8,1.469047619047619,0.5548811614832951,0.03143837889841219,1.5025398561957808,0.14559363133974043,0.8368576218258689,1686]
["High","O95372","acyl-protein thioesterase 2 [OS=Homo sapiens]",29,5,19,5,231,24.7,7.23,45.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;other cell component","other molecular function","LYPLA2","ENSG00000011009","","L1CAM interactions","Glycerophospholipid metabolism",708.5,724.6,647.7,679,649.8,646.8,1.0532496456772626,0.07484743056454704,0.2421351457876403,0.6159421683698019,0.4726478045774739,0.3254623550391288,4000]
["High","O95373","Importin-7 [OS=Homo sapiens]",43,36,155,35,1038,119.4,4.82,339.8,"stress response;transport;signal transduction;other biological processes","cytosol;nucleus","transporter activity;enzyme regulator activity;other molecular function","IPO7","ENSG00000205339","","","Nucleocytoplasmic transport",5207.6,5604.9,5774.5,4995.4,5451,5335,1.0510474355887311,0.07182778209200752,0.2827911868311822,0.5485341294233245,0.5131381795904882,0.2897656708472446,4303]
["High","O95376","E3 ubiquitin-protein ligase ARIH2 [OS=Homo sapiens]",31,11,24,11,493,57.8,5.63,55.14,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","ARIH2","ENSG00000177479","Modulators of TCR signaling and T cell activation","Antigen processing: Ubiquitination & Proteasome degradation","",477.1,536,505.3,561.3,489.7,563.2,0.9406517160203197,-0.0882674426882665,0.3409491647005261,0.46731036920643293,0.5729942053339879,0.24184977001201416,4646]
["High","O95379","Tumor necrosis factor alpha-induced protein 8 [OS=Homo sapiens]",19,3,6,3,198,23,7.93,13.26,"other biological processes","nucleus;other cell component","enzyme regulator activity","TNFAIP8","ENSG00000145779","","PI Metabolism","",77.8,90.6,76.7,86.2,85.2,89.5,0.9394403986201609,-0.09012645995061254,0.3203576218414176,0.49436493896010997,0.5532741232775468,0.25705964133576875,4521]
["High","O95391","Pre-mRNA-splicing factor SLU7 [OS=Homo sapiens]",11,4,5,4,586,68.3,7.14,8.18,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLU7","ENSG00000164609","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","Spliceosome",75.8,87,71.1,69.6,76,70.5,1.082369273484498,0.1141927894929205,0.3112094301049464,0.5069472517193269,0.5455597732957839,0.26315765975871086,4454]
["High","O95394","phosphoacetylglucosamine mutase [OS=Homo sapiens]",32,16,28,16,542,59.8,6.25,48.67,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PGM3","ENSG00000013375","Glucuronidation","Synthesis of UDP-N-acetyl-glucosamine","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",1744.9,1642.6,1683.1,1649.7,1996,1772.8,0.9357940389406663,-0.09573705620637561,0.3338952497894153,0.4763897594569184,0.5662584948644124,0.24698526975603724,4604]
["High","O95396","Adenylyltransferase and sulfurtransferase MOCS3 [OS=Homo sapiens]",15,7,12,7,460,49.6,6.21,29.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","MOCS3","ENSG00000124217","","Molybdenum cofactor biosynthesis","Sulfur relay system",331.6,361.7,349.6,371.7,343.1,355.2,0.9746728971962618,-0.03700996707230487,0.4950992484040361,0.30530773295800795,0.7029887127729976,0.15305164798125168,5499]
["High","O95400","CD2 antigen cytoplasmic tail-binding protein 2 [OS=Homo sapiens]",40,7,25,7,341,37.6,4.61,49.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","CD2BP2","ENSG00000169217","mRNA processing; Ciliary landscape","mRNA Splicing - Major Pathway","",703.9,713,623.4,733.5,641,631.4,1.017149409242734,0.024531612471271263,0.8039980078524117,0.09474502734579825,0.9024750496422701,0.04456479601783768,6956]
["High","O95405-1","Zinc finger FYVE domain-containing protein 9 [OS=Homo sapiens]",2,1,1,1,1425,156.3,5.01,0,"transport;signal transduction","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ZFYVE9","ENSG00000157077","TGF-beta signaling pathway; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling","","Endocytosis; TGF-beta signaling pathway",20.2,20.2,18,29.5,27.6,29,0.6782810685249709,-0.5600448685168268,5.729850587451674E-4,3.241856702620967,0.021406063821446254,1.6694631840733858,209]
["High","O95409","Zinc finger protein ZIC 2 [OS=Homo sapiens]",6,3,6,2,532,55,8.41,13.67,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZIC2","ENSG00000043355","Mesodermal commitment pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Ciliopathies","","",157.1,157.1,150.2,156.5,165.6,135.8,1.014195239135182,0.02033540719201895,0.8237363468336694,0.08421177063033114,0.9146378549597967,0.038750828037411235,7032]
["High","O95425","Supervillin [OS=Homo sapiens]",11,16,21,16,2214,247.6,6.98,37.41,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SVIL","ENSG00000197321","","","",536.4,500.6,512.3,607.3,565.4,576.8,0.8855673049442697,-0.17532613594031157,0.015096849277744748,1.8211136807906976,0.10049121838075958,0.9978718882475914,1173]
["High","O95427","GPI ethanolamine phosphate transferase 1 [OS=Homo sapiens]",2,2,2,2,931,105.7,8.65,4.32,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","PIGN","ENSG00000197563","","Synthesis of glycosylphosphatidylinositol (GPI)","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways",125.2,124.6,117.4,135.7,122.3,133.3,0.93841042678252,-0.09170905148698602,0.1713790090621921,0.7660423726504392,0.38429847867822975,0.4153313347731162,3482]
["High","O95433","activator of 90 kDa heat shock protein ATPase homolog 1 [OS=Homo sapiens]",71,19,96,19,338,38.3,5.53,234.42,"other biological processes","cytosol;ER/Golgi","other molecular function","AHSA1","ENSG00000100591","T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection","","",4489.2,4315.2,4427.3,4538.1,4497.1,4653.8,0.9665936153115641,-0.04901862959489381,0.09249726022423399,1.0338711309054935,0.2705952071303181,0.5676799000343657,2669]
["Medium","O95452","Gap junction beta-6 protein [OS=Homo sapiens]",2,1,1,1,261,30.4,8.51,1.99,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","transporter activity;cytoskeletal activity","GJB6","ENSG00000121742","Calcium regulation in cardiac cells","Gap junction assembly","",71.9,64.2,57.6,77.9,83.8,76.6,0.8128409567771718,-0.2989549975870169,0.03382973991703701,1.470701341054167,0.15312615030273913,0.8149506358048245,1725]
["High","O95453","poly(A)-specific ribonuclease PARN [OS=Homo sapiens]",16,9,20,9,639,73.4,6.2,38.49,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARN","ENSG00000140694; ENSG00000274829","Lung fibrosis","Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA","RNA degradation",843.7,830.9,889,892.4,937.2,943.7,0.9243861104099808,-0.11343251248682305,0.04298489821370176,1.3666840973142331,0.1746233534092525,0.7578976759881244,1922]
["High","O95456","Proteasome assembly chaperone 1 [OS=Homo sapiens]",46,10,26,10,288,32.8,7.17,55.54,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","PSMG1","ENSG00000183527","","","",1050.9,995.3,1188.1,1062.8,1329.7,1216.8,0.8961017371789544,-0.15826555971242146,0.2638941858471918,0.5785701781099901,0.4940028297997779,0.3062705632971861,4171]
["Medium","O95460","matrilin-4 [OS=Homo sapiens]",2,1,1,1,622,68.4,6.1,0,"","non-structural extracellular;extracellular matrix","other molecular function","MATN4","ENSG00000124159","","ECM proteoglycans","",72.2,82.9,73.6,77.7,72.4,71.8,1.0306444344299233,0.04354669821466103,0.5872655666270348,0.23116546256973144,0.7694864145366483,0.11379904333588282,5959]
["High","O95470","sphingosine-1-phosphate lyase 1 [OS=Homo sapiens]",13,7,15,7,568,63.5,9.16,27.09,"other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","SGPL1","ENSG00000166224","Sphingolipid pathway; Kennedy pathway from sphingolipids; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",740.1,775.4,753.6,736.2,740.7,747.2,1.0202329031967985,0.028898534482451554,0.23603976566388324,0.6270148251927272,0.4655212150299572,0.3320605222862964,3959]
["High","O95478","Ribosome biogenesis protein NSA2 homolog [OS=Homo sapiens]",24,5,21,5,260,30,10.27,29.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","NSA2","ENSG00000164346","","","",907.8,882.9,887.6,1005.1,1046.5,1039.8,0.8663712233939316,-0.2069427704041159,0.000768293762627998,3.1144726926055273,0.02468657489135559,1.6075391615452042,243]
["High","O95479","GDH/6PGL endoplasmic bifunctional protein [OS=Homo sapiens]",11,8,14,8,791,88.8,7.3,27.85,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","H6PD","ENSG00000049239","Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism","","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism",464.8,454.4,473.9,419.4,442.5,430.9,1.0775835396039604,0.10779971850276635,0.01861850942262389,1.7300550911012738,0.11225739117517168,0.949785054859909,1295]
["High","O95486-1","Protein transport protein Sec24A [OS=Homo sapiens]",8,9,15,9,1093,119.7,7.66,32.26,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi","other molecular function","SEC24A","ENSG00000113615","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",553.9,551.4,555.9,497.4,547,565.2,1.0320576540755464,0.04552356661926747,0.4445846023192379,0.35204558267074,0.6622122424472738,0.17900279462268628,5242]
["High","O95487-1","Protein transport protein Sec24B [OS=Homo sapiens]",8,9,13,9,1268,137.3,6.67,27.89,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SEC24B","ENSG00000138802","Sterol regulatory element-binding proteins (SREBP) signaling","COPII-mediated vesicle transport; MHC class II antigen presentation; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",423,423.4,458.5,429.1,424.3,434.8,1.0129638254929358,0.018582654184650244,0.6706784129830681,0.17348567200020196,0.8233737497754395,0.08440298298998045,6360]
["High","O95490-1","Adhesion G protein-coupled receptor L2 [OS=Homo sapiens]",16,16,33,16,1459,163.2,6.43,61.6,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ADGRL2","ENSG00000117114","GPCRs, other; GPCRs, class B secretin-like","","",1036.4,1024.7,976.8,1017.3,929.9,936.5,1.0534729687554187,0.07515329626928807,0.19968076582493857,0.6996637663681271,0.419453166414076,0.37731652280521755,3717]
["High","O95502","neuronal pentraxin receptor [OS=Homo sapiens]",2,1,2,1,500,52.8,6.21,4.73,"other biological processes","other membranes;other cell component","other molecular function","NPTXR","ENSG00000221890","","","",61.9,53.2,54.9,56.2,38.7,53.2,1.1478730587440915,0.198963105736216,0.2922320038829439,0.5342722238957279,0.5250224312742812,0.2798221412215983,4346]
["High","O95528","Solute carrier family 2, facilitated glucose transporter member 10 [OS=Homo sapiens]",4,2,2,2,541,56.9,8.59,2.24,"transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC2A10","ENSG00000197496","Nuclear receptors meta-pathway; NRF2 pathway","Cellular hexose transport; Defective SLC2A10 causes arterial tortuosity syndrome (ATS)","",26.3,22.5,19.1,19.9,20.8,21,1.1004862236628852,0.13814108509531423,0.3821711185477351,0.41774213656224146,0.6109729921418338,0.21397798717645086,4884]
["High","O95544","NAD kinase [OS=Homo sapiens]",4,1,2,1,446,49.2,6.47,2.77,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NADK","ENSG00000008130","NAD+ metabolism","Nicotinate metabolism","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors",38.5,37.8,35.3,28.8,45.5,43.1,0.9505962521294717,-0.07309538128086485,0.7338681069729129,0.13438198580717597,0.8634783271917577,0.06374855850086368,6636]
["High","O95551-1","Tyrosyl-DNA phosphodiesterase 2 [OS=Homo sapiens]",23,6,14,6,362,40.9,5.1,33.83,"DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TDP2","ENSG00000111802","Oxidative damage response","Nonhomologous End-Joining (NHEJ)","",667.6,529.4,461.9,513.2,530.2,495.5,1.0779777763337448,0.10832743569376684,0.5500424212485102,0.25960381486268513,0.7462608557964149,0.12710933816986034,5755]
["High","O95562","Vesicle transport protein SFT2B [OS=Homo sapiens]",17,2,3,2,160,17.8,9.13,9.05,"transport","other membranes","","SFT2D2","ENSG00000213064","TYROBP causal network in microglia","","",80.7,88.7,78.2,109.4,96.1,94.4,0.8256085361787264,-0.2764702076544753,0.03775874202252602,1.4229824831710043,0.16252494912452214,0.7890799612364454,1814]
["Medium","O95563","Mitochondrial pyruvate carrier 2 [OS=Homo sapiens]",8,1,1,1,127,14.3,10.43,2,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MPC2","ENSG00000143158","Glycolysis and gluconeogenesis","Pyruvate metabolism","Diabetic cardiomyopathy",29.7,42.9,39.1,22.6,26.8,25.9,1.48339973439575,0.5689074158113863,0.0423494627074538,1.373152095242795,0.17366838488434838,0.760279234632615,1904]
["Medium","O95568","histidine protein methyltransferase 1 homolog [OS=Homo sapiens]",3,1,1,1,372,42.1,6.76,2.2,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","METTL18","ENSG00000171806","","","",39.1,52.7,46.5,49.5,51.7,51.6,0.9051047120418848,-0.14384338688525455,0.29304758236783385,0.5330618571816632,0.5257618389540548,0.27921093921315127,4352]
["High","O95571","Persulfide dioxygenase ETHE1, mitochondrial [OS=Homo sapiens]",12,2,4,2,254,27.9,6.83,12.38,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","ETHE1","ENSG00000105755","","Sulfide oxidation to sulfate","Sulfur metabolism; Metabolic pathways",107.8,123.5,104.9,101.4,81.5,101,1.1842197957027125,0.24393687551177612,0.11704973673402327,0.9316295587729061,0.3108586205507666,0.507437084526428,2940]
["High","O95573","long-chain-fatty-acid--CoA ligase 3 [OS=Homo sapiens]",34,19,75,16,720,80.4,8.38,200.86,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL3","ENSG00000123983","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Ciliary landscape; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway",4031.2,4256.9,4213.1,3942.2,4325.7,4345,0.9911439875048561,-0.01283343609357943,0.8140785495594977,0.08933368848377335,0.908825466823071,0.04151951179836385,6994]
["High","O95602","DNA-directed RNA polymerase I subunit RPA1 [OS=Homo sapiens]",31,42,105,41,1720,194.7,7.03,243.35,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR1A","ENSG00000068654","Pyrimidine metabolism; Eukaryotic transcription initiation","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase",3737.7,3766.7,3812.5,3870.1,3882.4,3900.6,0.9711493079094832,-0.04223497718202234,0.00885717686709368,2.052704682900853,0.07500741537773042,1.1248957992958468,922]
["High","O95613","Pericentrin [OS=Homo sapiens]",12,29,38,29,3336,377.8,5.55,73.09,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton","other molecular function","PCNT","ENSG00000160299","","Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy","",1091.4,1113.7,1109.8,1280.9,1223.6,1264.8,0.8794471121958986,-0.18533127474206676,1.1862416230753066E-3,2.9258268414266237,0.029497371315197432,1.530216684841203,314]
["High","O95619","YEATS domain-containing protein 4 [OS=Homo sapiens]",30,7,12,7,227,26.5,8.41,24.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus","cytoskeletal activity;other molecular function","YEATS4","ENSG00000127337","","HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors","",593.8,665.6,595,731.2,729.4,697.6,0.8592345473079418,-0.2188760938500642,0.017896463593425095,1.7472327787181645,0.1105503067543221,0.9564400480058954,1264]
["High","O95625","Zinc finger and BTB domain-containing protein 11 [OS=Homo sapiens]",6,6,6,6,1053,119.3,8.66,10.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB11","ENSG00000066422","","","",243.7,231.6,254.7,236.1,244.6,245.5,1.0052327182594325,0.007529533854534493,0.8708867325403734,0.06003832562548637,0.934691904835084,0.029331518624795827,7275]
["High","O95628-1","CCR4-NOT transcription complex subunit 4 [OS=Homo sapiens]",19,8,15,8,575,63.5,7.03,22.75,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CNOT4","ENSG00000080802","","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",334.5,322.2,318.4,279.2,289.4,273.7,1.1576635403063043,0.2112160138940275,2.7055952889437945E-3,2.5677371659510553,0.042677349527420506,1.3698025602259885,495]
["High","O95630","STAM-binding protein [OS=Homo sapiens]",17,8,15,8,424,48,6.29,30.37,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","STAMBP","ENSG00000124356","EGF/EGFR signaling pathway","Metalloprotease DUBs","Endocytosis",909.1,902.5,910.1,836.1,903.9,829,1.0594394706111325,0.08330116397841685,0.10114882576018527,0.9950391546018474,0.28480707952958045,0.5454492195210736,2773]
["High","O95639","Cleavage and polyadenylation specificity factor subunit 4 [OS=Homo sapiens]",13,3,11,3,269,30.2,8.31,18.7,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CPSF4","ENSG00000160917","mRNA processing","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA surveillance pathway; Influenza A",493.6,541.4,506.6,541.9,515.5,518.7,0.978110525981854,-0.03193059670741108,0.5245974249660731,0.2801738455141934,0.724196728100265,0.14014344164440093,5656]
["High","O95671-1","N-acetylserotonin O-methyltransferase-like protein [OS=Homo sapiens]",40,20,61,20,621,68.8,6.07,143.5,"other metabolic processes","cytosol","other molecular function","ASMTL","ENSG00000169093","","","Pyrimidine metabolism; Metabolic pathways",2781.5,2528.2,2678.3,2394.9,2546.6,2453.5,1.0801893171061527,0.11128418545754241,0.08254992176863318,1.0832833339755912,0.2524676024949032,0.5977943441212061,2553]
["High","O95674-1","phosphatidate cytidylyltransferase 2 [OS=Homo sapiens]",28,8,30,8,445,51.4,7.09,76.88,"cell organization and biogenesis;other metabolic processes","other membranes;mitochondrion;ER/Golgi","other molecular function","CDS2","ENSG00000101290","","Synthesis of PG","Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system",923.3,937.5,949.7,844.7,902.7,884.3,1.067940874719763,0.0948317761361361,0.03349762259268066,1.4749860147995275,0.152240650293161,0.8174693696361156,1718]
["High","O95684","FGFR1 oncogene partner [OS=Homo sapiens]",29,6,8,6,399,43,4.81,15.09,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","CEP43","ENSG00000213066","Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",151.6,112.4,168.7,113.4,148.7,145.5,1.0615799803729145,0.08621306925607719,0.698846672481837,0.15561809835932605,0.8421970703408216,0.07458627364601733,6479]
["High","O95696-2","Isoform 2 of Bromodomain-containing protein 1 [OS=Homo sapiens]",10,9,13,9,1189,133.2,8.59,26.54,"","","","BRD1","","","","",491.4,518.8,487.9,537.7,530.2,550.8,0.9254957682090564,-0.11170170143955857,0.02482059856513577,1.6051877494125901,0.1276674793126351,0.8939197163134164,1518]
["High","O95707","Ribonuclease P protein subunit p29 [OS=Homo sapiens]",6,1,2,1,220,25.4,10.07,3.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP4","ENSG00000105171","","tRNA processing in the nucleus","Ribosome biogenesis in eukaryotes",40.5,48.1,42,42.4,42.4,38.1,1.0626525630593977,0.08766998117376888,0.40043744395724895,0.3974653194452329,0.6270789334974327,0.20267778895435218,4986]
["High","O95714","E3 ubiquitin-protein ligase HERC2 [OS=Homo sapiens]",3,14,19,14,4834,526.9,6.28,37.23,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HERC2","ENSG00000128731","Prader-Willi and Angelman syndrome","SUMOylation of DNA damage response and repair proteins; Antigen processing: Ubiquitination & Proteasome degradation; Nonhomologous End-Joining (NHEJ); Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint","Ubiquitin mediated proteolysis",383.6,372.8,382,380.7,406.5,386.1,0.9702548367851358,-0.043564374927619255,0.24509664914135104,0.6106626261994467,0.47486715545798236,0.3234278676819207,4030]
["High","O95716","ras-related protein Rab-3D [OS=Homo sapiens]",41,8,19,5,219,24.3,4.93,39.34,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3D","ENSG00000105514","","Neutrophil degranulation; RAB geranylgeranylation","Pancreatic secretion",599.1,550.7,638.3,551.1,666.8,576.6,0.9964335469490111,-0.005154501246933198,0.9630549886506765,0.01634891475941654,0.9799991335050805,0.008774308301513817,7673]
["High","O95747","Serine/threonine-protein kinase OSR1 [OS=Homo sapiens]",37,16,61,14,527,58,6.43,137.72,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol","kinase activity;other molecular function","OXSR1","ENSG00000172939","","","",2061.5,2059.7,2134.4,2098.1,2092.5,2054.3,1.0017133981328763,2.469795721384933E-3,0.9054319035165109,0.0431442069060783,0.9520081204762884,0.02135934713758299,7426]
["High","O95749","geranylgeranyl pyrophosphate synthase [OS=Homo sapiens]",17,5,9,5,300,34.8,6.14,16.5,"other metabolic processes","cytosol","other molecular function","GGPS1","ENSG00000152904","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Terpenoid backbone biosynthesis; Metabolic pathways",497.2,517,466.6,506.3,467.2,486.3,1.014385532264694,0.02060607421098895,0.7244097384904833,0.14001571994791517,0.8582991256652038,0.06636132988328967,6590]
["High","O95754-1","Semaphorin-4F [OS=Homo sapiens]",2,1,2,1,770,83.5,6.95,5.43,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","SEMA4F","ENSG00000135622","","RND3 GTPase cycle","Axon guidance",31,35.9,30.2,22.2,23.3,22.8,{"$f":"AVERAGE(T898:V898)/AVERAGE(W898:Y898)","v":1.4216691068814056},{"$f":"LOG(Z898,2)","v":0.5075857171291018},{"$f":"TTEST(T898:V898,W898:Y898,2,2)","v":0.006069480335614444},{"$f":"-LOG10(AB898)","v":2.216848491303063},{"$f":"AB898*7808/AF898","v":0.06227398483637001},{"$f":"-LOG10(AD898)","v":1.2056933434150003},761]
["High","O95757","Heat shock 70 kDa protein 4L [OS=Homo sapiens]",31,19,58,14,839,94.5,5.88,120.14,"stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","HSPA4L","ENSG00000164070","","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",968.2,969.8,983.9,944.1,954.7,936.1,1.0306889131891777,0.043608958193606495,0.016816596642863082,1.7742618925321532,0.10657791119113226,0.9723327957019244,1232]
["High","O95758-1","Isoform 1 of Polypyrimidine tract-binding protein 3 [OS=Homo sapiens]",9,6,44,2,521,56.5,9.22,71.01,"","","","PTBP3","","","","",154.2,144.8,155.1,168.6,175.9,151.6,0.9153396492642613,-0.1276209204683441,0.15170695089878228,0.8189945202822991,0.3596016613897062,0.4441783104573992,3294]
["High","O95772-1","STARD3 N-terminal-like protein [OS=Homo sapiens]",12,3,5,3,234,26.6,4.81,9.62,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STARD3NL","ENSCANG00000042172; ENSCATG00000036966; ENSCSAG00000015104; ENSG00000010270; ENSGGOG00000013471; ENSMFAG00000043802; ENSMLEG00000030425; ENSMMUG00000023659; ENSMNEG00000034363; ENSPANG00000016262; ENSPPAG00000039214; ENSPTRG00000019094; ENSRBIG00000036179; ENSRROG00000026971","","Pregnenolone biosynthesis","",369.1,351,381.6,382.6,378.2,401.1,0.9481883122471814,-0.07675448495630989,0.15094626765007785,0.8211776210245569,0.3584514774366812,0.44556962523393434,3288]
["High","O95777","U6 snRNA-associated Sm-like protein LSm8 [OS=Homo sapiens]",52,3,17,3,96,10.4,4.48,40.09,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","LSM8","ENSG00000128534","","mRNA Splicing - Major Pathway","RNA degradation; Spliceosome",263.9,285.3,304.2,297.2,326,295.6,0.9288202002612103,-0.10652874617681246,0.2264982101926877,0.644935225467973,0.4538101168038249,0.34312582660202784,3897]
["High","O95782-2","Isoform B of AP-2 complex subunit alpha-1 [OS=Homo sapiens]",40,31,81,22,955,105.3,7.66,182.32,"","","","AP2A1","","","","",3172.2,3136.1,3416.5,2880.4,3086.6,2867.6,1.1007629094695854,0.13850376393734518,0.05857697180585072,1.2322730833543518,0.20555909926295837,0.6870632940126669,2225]
["High","O95785-3","Isoform 3 of Protein Wiz [OS=Homo sapiens]",19,12,21,3,965,102.9,9.52,51.56,"","","","WIZ","","","","",457.8,429.5,466,482.2,513.4,505.1,0.901779169720797,-0.1491539094712409,0.02737015621649746,1.5627227238259298,0.13508608074488757,0.8693893983289522,1582]
["High","O95785-4","Isoform 4 of Protein Wiz [OS=Homo sapiens]",19,10,20,1,835,89.3,9.48,51.01,"","","","WIZ","","","","",15.9,14.7,13.5,19.5,11.7,18.6,0.8855421686746989,-0.17536708651056016,0.49907910088427915,0.3018306159897576,0.7050496869376609,0.1517802759128973,5527]
["High","O95786","Probable ATP-dependent RNA helicase DDX58 [OS=Homo sapiens]",1,1,1,1,925,106.5,6.4,3.27,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","DDX58","ENSG00000107201","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Pathways of nucleic acid metabolism and innate immune sensing; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation","ISG15 antiviral mechanism; Ub-specific processing proteases; OAS antiviral response; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation","NF-kappa B signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease",43.2,41.2,40.2,44.6,47.3,56.9,0.8373655913978495,-0.25607045808402945,0.10325702391976134,0.9860803963704479,0.28804245900875186,0.5405434901779749,2799]
["High","O95789","Zinc finger MYM-type protein 6 [OS=Homo sapiens]",3,3,4,3,1325,148,8.22,0,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZMYM6","ENSG00000163867","","","",28.5,26.9,19.2,23.5,27.7,28.9,0.9313358302122346,-0.10262661215347244,0.6086136204787461,0.2156583325684382,0.7827466889636056,0.10637876078275177,6071]
["High","O95793","double-stranded RNA-binding protein Staufen homolog 1 [OS=Homo sapiens]",36,18,38,18,577,63.1,9.44,75.33,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","STAU1","ENSG00000124214","","","",2170.1,2159.3,2000.2,2063.9,1908.4,1873.9,1.0826861893195576,0.11461514625443545,0.11489887868788937,0.9396842096236241,0.3070261618052841,0.5128246165632667,2922]
["High","O95801","Tetratricopeptide repeat protein 4 [OS=Homo sapiens]",51,15,50,15,387,44.7,5.6,111.91,"stress response","nucleus;other cell component","other molecular function","TTC4","ENSG00000243725","","","",2293.4,2223.6,2284.3,2433.2,2322.8,2305.4,0.963165944430283,-0.054143712621698016,0.1301732102185212,0.8854783848261791,0.3290360716692178,0.48275648846899427,3089]
["Medium","O95807","transmembrane protein 50A [OS=Homo sapiens]",6,1,1,1,157,17.4,5.87,2.4,"transport","other membranes;ER/Golgi;other cell component","","TMEM50A","ENSG00000183726","","","",61.3,50.1,60,54.7,59.5,62.8,0.9683615819209039,-0.04638225085785997,0.6829891388257225,0.1655862025930808,0.8309098155112561,0.08044611069393064,6418]
["High","O95816","BAG family molecular chaperone regulator 2 [OS=Homo sapiens]",37,8,19,8,211,23.8,6.7,30.16,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","BAG2","ENSG00000112208","Malignant pleural mesothelioma","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",719.4,716,718.4,868.7,766.6,726.4,0.9119701909641359,-0.13294142625507838,0.17723447528147146,0.7514517961723978,0.389267730801049,0.4097515965795475,3555]
["High","O95817","BAG family molecular chaperone regulator 3 [OS=Homo sapiens]",2,1,1,1,575,61.6,6.95,2.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BAG3","ENSG00000151929","","Regulation of HSF1-mediated heat shock response","",18.4,20.4,18.4,34.1,14.5,13.4,0.9225806451612902,-0.11625306849584828,0.8244542901319376,0.08383341775599144,0.9145246622176686,0.038804578300604166,7039]
["High","O95819","Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",18,19,46,1,1239,142,7.46,103.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","cytoskeletal activity;kinase activity;other molecular function","MAP4K4","ENSG00000071054","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma","Oxidative Stress Induced Senescence","MAPK signaling pathway",42.6,35,35.6,47.6,34.1,38.5,0.941763727121464,-0.08656293787930354,0.6431407307340244,0.19169398525025383,0.8050084683506352,0.09419955101274341,6238]
["High","O95819-3","Isoform 3 of Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",17,19,47,1,1320,150.9,7.42,106.24,"","","","MAP4K4","","","","",2180.4,2139.9,2333.5,2326.2,2372.1,2328.5,0.9469175157966643,-0.07868933417138647,0.11038667149518293,0.9570833618019511,0.30031328607469976,0.522425453877308,2870]
["High","O95822","Malonyl-CoA decarboxylase, mitochondrial [OS=Homo sapiens]",14,5,7,5,493,55,8.95,19.9,"other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","MLYCD","ENSG00000103150","","","beta-Alanine metabolism; Propanoate metabolism; Metabolic pathways; Peroxisome; AMPK signaling pathway; Alcoholic liver disease",266.7,273.6,291.3,268.5,294.8,300.6,0.9626114133580276,-0.05497456593590678,0.4306942434542914,0.36583093286415497,0.652982651046817,0.18509835724671056,5150]
["High","O95825-1","Quinone oxidoreductase-like protein 1 [OS=Homo sapiens]",22,6,16,6,349,38.7,5.78,20.08,"other metabolic processes","","other molecular function","CRYZL1","ENSG00000205758","","","",387.2,345.1,382.2,356.1,408.9,398.9,0.9575564911074834,-0.0625704934512914,0.4756409552607713,0.3227207573376758,0.6881238796879938,0.1623333707442542,5397]
["High","O95831-1","Apoptosis-inducing factor 1, mitochondrial [OS=Homo sapiens]",29,16,46,16,613,66.9,8.95,115.94,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","AIFM1","ENSG00000156709","Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70","","Apoptosis; Necroptosis",1964.6,2003.1,2022,2075.2,2134.8,2172.2,0.9385008304346463,-0.09157007325857992,0.016461489671115055,1.7835308661668037,0.1057870875325649,0.9755673394424992,1215]
["High","O95834","echinoderm microtubule-associated protein-like 2 [OS=Homo sapiens]",6,4,5,4,649,70.6,6.32,10.72,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","EML2","ENSG00000125746","","","",343.8,304.8,299.3,322.4,367.8,324.1,0.9345361332938973,-0.09767764887719793,0.3393619603485447,0.46933684008724763,0.5715569858501806,0.24294046272017064,4636]
["Medium","O95857","Tetraspanin-13 [OS=Homo sapiens]",4,1,1,1,204,22.1,7.93,1.89,"other biological processes","plasma membrane;other membranes","other molecular function","TSPAN13","ENSG00000106537","","","",97.8,96.2,94.6,98.2,93.9,89.4,1.0252220248667852,0.035936377523606296,0.43073812460762734,0.36578668715555057,0.6529223989393038,0.18513843237749414,5151]
["High","O95861-1","3'(2'),5'-bisphosphate nucleotidase 1 [OS=Homo sapiens]",47,11,21,11,308,33.4,5.69,35.66,"other metabolic processes;developmental processes","cytosol","other molecular function","BPNT1; HEL20","ENSG00000162813; ENSPTRG00000001996","","Cytosolic sulfonation of small molecules","Sulfur metabolism; Metabolic pathways",897.2,717.5,852.4,845.5,916.7,844.7,0.9463730868080862,-0.07951904834469557,0.474119439641519,0.32411223756026497,0.6866860665407124,0.16324176473026578,5391]
["High","O95863","Zinc finger protein SNAI1 [OS=Homo sapiens]",4,1,1,1,264,29.1,8.65,2.92,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SNAI1","ENSG00000124216","Neural crest differentiation; Mesodermal commitment pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Epithelial to mesenchymal transition in colorectal cancer; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; CCL18 signaling pathway","Regulation of PTEN gene transcription","Adherens junction",15.8,28.5,9.4,22.3,15,18.6,0.960644007155635,-0.05792619485777755,0.9085473435386295,0.04165243709357681,0.9533581048716059,0.020743936972495006,7441]
["High","O95864","fatty acid desaturase 2 [OS=Homo sapiens]",16,7,10,7,444,52.2,8.82,19.47,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","FADS2","ENSG00000134824","PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis","alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","alpha-Linolenic acid metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway",394.1,403,374.8,530.9,549.1,546.5,0.7205041500153706,-0.4729213547172466,1.140167528267304E-4,3.943031331771758,0.010990651926803839,1.9589765459917723,81]
["High","O95865","N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [OS=Homo sapiens]",48,10,40,9,285,29.6,6.01,100.42,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion","other molecular function","DDAH2","ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076","Nitric oxide metabolism in cystic fibrosis","eNOS activation","",1402.3,1333.8,1272,1307.1,1364.5,1344.3,0.998057720560771,-2.8048416907870484E-3,0.9527263505575958,0.021031822875722805,0.9767446619161907,0.010218953593505319,7616]
["High","O95873","Uncharacterized protein C6orf47 [OS=Homo sapiens]",4,1,1,1,294,31.7,6.37,2.78,"","","","C6orf47","ENSG00000203623; ENSG00000204439; ENSG00000226103; ENSG00000226531; ENSG00000228177; ENSG00000228435; ENSG00000235360","","","",45.8,32.6,52.7,46.3,48.5,51.7,0.8948805460750855,-0.1602329790878554,0.44752013275674063,0.3491874221391744,0.6651888818893262,0.17705501828364759,5253]
["High","O95881","Thioredoxin domain-containing protein 12 [OS=Homo sapiens]",31,5,18,5,172,19.2,5.4,40.09,"other biological processes","ER/Golgi","other molecular function","TXNDC12","ENSG00000117862","","","Glutathione metabolism; Metabolic pathways",1083.8,1094,1043.3,1008.3,921.9,909.8,1.1341901408450705,0.18166252057928997,0.021490623577762925,1.667750982719241,0.11925997789280236,0.9235052754953511,1407]
["High","O95900","Mitochondrial mRNA pseudouridine synthase TRUB2 [OS=Homo sapiens]",8,3,6,2,331,36.7,8.98,11.66,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","TRUB2","ENSG00000167112","","","",193.6,198.8,212.9,188,196.3,164.8,1.102349298852668,0.1405814397659335,0.16524876134144462,0.7818617871802447,0.37540364520046543,0.4255015146588345,3437]
["High","O95905","Protein ecdysoneless homolog [OS=Homo sapiens]",21,9,9,9,644,72.7,4.87,11.41,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ECD","ENSG00000122882","","","",209.3,232.6,220.9,300.7,276.7,301.8,0.7538671519563238,-0.40761778372777946,0.002434389588608492,2.613609918035508,0.0405281746436143,1.3922429560919558,469]
["High","O95983-1","methyl-CpG-binding domain protein 3 [OS=Homo sapiens]",29,8,27,8,291,32.8,5.34,30.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MBD3","ENSG00000071655; ENSPTRG00000010209","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; Regulation of TP53 Activity through Acetylation","",946.4,888.2,793.9,939.1,798.9,792.5,1.0387275242047025,0.05481726056315379,0.6431043862103378,0.19171852835775452,0.8052211429650927,0.09408483021592313,6236]
["High","O95985","DNA topoisomerase 3-beta-1 [OS=Homo sapiens]",13,7,11,7,862,96.6,8.12,19.99,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP3B","ENSG00000100038","","","Homologous recombination; Fanconi anemia pathway",315.7,321.2,327.2,284.9,276,287.3,1.1366423013440223,0.18477831292104277,0.001272678395558167,2.895281328224048,0.0307649316177033,1.5119440458965154,323]
["High","O95989","Diphosphoinositol polyphosphate phosphohydrolase 1 [OS=Homo sapiens]",25,3,10,3,172,19.5,6.34,26.94,"cell-cell signaling;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT3","ENSG00000272325","","Synthesis of pyrophosphates in the cytosol","",511.9,477,521.6,477.8,547.6,502.2,0.9888059701492536,-0.016240641007211034,0.8276476500177996,0.08215451372395474,0.9162445556981397,0.03798859290992116,7053]
["High","O95995","Growth arrest-specific protein 8 [OS=Homo sapiens]",4,2,2,2,478,56.3,7.94,2.7,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","GAS8","ENSG00000141013","Ciliopathies","Activation of SMO","",42.5,40.3,38.6,34.2,35.9,35.3,1.1518026565464896,0.20389355461846753,0.012420490042996842,1.9058612689926941,0.09114585174409713,1.040263092293088,1064]
["High","O95997","Securin [OS=Homo sapiens]",7,1,1,1,202,22,6.6,2.33,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PTTG1","ENSG00000164611","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition","APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids","Cell cycle; Oocyte meiosis; Human T-cell leukemia virus 1 infection",27.4,27.1,24.6,27.3,22,20.5,1.13323782234957,0.18045065826313939,0.2395466611605584,0.6206098780291748,0.4699448066185025,0.3279531454442272,3980]
["Medium","O95999","B-cell lymphoma/leukemia 10 [OS=Homo sapiens]",3,1,1,1,233,26.2,5.74,2.26,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BCL10","ENSG00000142867","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling","NF-kappa B signaling pathway; C-type lectin receptor signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway; Shigellosis; Tuberculosis",71.3,76.7,81.9,97.6,61.8,53.3,1.0808650681711334,0.11218643275750813,0.7014303988806734,0.15401541641281388,0.8434881494625439,0.07392101462693444,6493]
["High","O96000","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [OS=Homo sapiens]",19,3,3,3,172,20.8,8.48,6.91,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB10","ENSG00000140990","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Modulators of TCR signaling and T cell activation; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",57.8,55.3,57.5,69.6,47.9,55.8,0.9844200807847662,-0.022654007841879667,0.894796394135312,0.04827577469866659,0.946305058297239,0.02396883846249618,7383]
["High","O96005-1","Cleft lip and palate transmembrane protein 1 [OS=Homo sapiens]",26,10,31,10,669,76,6.3,69.79,"developmental processes;other biological processes","plasma membrane;other membranes;other cell component","","CLPTM1","ENSG00000104853","","","",991.4,995.1,1092.2,903.8,979.8,1029.2,1.0569555067289205,0.07991464675599216,0.3237775198908239,0.48975330791830163,0.556595084832134,0.25446063314338263,4542]
["High","O96006","zinc finger BED domain-containing protein 1 [OS=Homo sapiens]",10,7,11,7,694,78.1,6.1,24.05,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED1","ENSG00000214717","","SUMOylation of chromatin organization proteins","",464.2,482,480.3,613.2,618.8,574,0.7898671096345515,-0.34031814589913856,1.1363987904229609E-3,2.944469237209673,0.029478411148247438,1.530495928144881,301]
["High","O96007","molybdopterin synthase catalytic subunit [OS=Homo sapiens]",23,3,4,3,188,20.9,5.44,8.19,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","MOCS2","ENSG00000164172","","Molybdenum cofactor biosynthesis","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system",284.9,278.7,279.3,253.5,239,276,1.096811971372804,0.13331622289819595,0.0860885377628749,1.06505466872887,0.25853050109712583,0.5874882120410525,2600]
["High","O96008","Mitochondrial import receptor subunit TOM40 homolog [OS=Homo sapiens]",45,12,98,12,361,37.9,7.25,220.56,"cell organization and biogenesis;transport","other membranes;cytosol;mitochondrion;other cell component","transporter activity","TOMM40","ENSG00000130204","IL-18 signaling pathway","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",2776.1,2963.4,3104.2,2268.4,2941.6,2735.4,1.1130591285523699,0.15453023437209423,0.2462919886759312,0.6085497145531894,0.4762377037101711,0.3221762245021745,4038]
["High","O96011-1","Peroxisomal membrane protein 11B [OS=Homo sapiens]",7,2,3,2,259,28.4,9.85,7.3,"cell organization and biogenesis;signal transduction","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PEX11B","ENSG00000131779; ENSPPAG00000024465; ENSPTRG00000001203","","Class I peroxisomal membrane protein import","Peroxisome",226,232.2,206.6,224.3,225.4,229.3,0.9790868924889543,-0.03049119236174968,0.5794347503230017,0.23699546249614373,0.765002795150828,0.11633697802760723,5914]
["High","O96013-1","serine/threonine-protein kinase PAK 4 [OS=Homo sapiens]",12,6,13,6,591,64,9.73,26.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","PAK4","ENSG00000130669","Integrin-mediated cell adhesion; Focal adhesion; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle","ErbB signaling pathway; Ras signaling pathway; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Regulation of actin cytoskeleton; Human immunodeficiency virus 1 infection; MicroRNAs in cancer; Renal cell carcinoma",416.1,394.8,375.6,456.8,399.4,449.1,0.9089864398988736,-0.1376693221803756,0.13869322848932233,0.857944742254122,0.34075416238031114,0.46755883046684726,3178]
["High","O96017-1","Serine/threonine-protein kinase Chk2 [OS=Homo sapiens]",26,11,24,11,543,60.9,5.91,43.01,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","CHEK2","ENSG00000183765","miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection",698.2,709.2,755.4,900.1,968.6,920.3,0.7754750806740768,-0.3668476728336751,1.4726027760448642E-3,2.8319143851578166,0.032480458969938696,1.4883778425249692,354]
["High","O96018","amyloid-beta A4 precursor protein-binding family A member 3 [OS=Homo sapiens]",3,2,2,2,575,61.4,4.94,2.99,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","APBA3","ENSG00000011132","","Neurexins and neuroligins","",99.9,115.1,115.9,90.7,101.6,124.8,1.0435193945127719,0.06145741420869941,0.7053374283157369,0.1516030699627069,0.8462315058834163,0.07251080956889266,6508]
["High","O96019-1","Actin-like protein 6A [OS=Homo sapiens]",47,18,54,18,429,47.4,5.6,115.33,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","ACTL6A","ENSCANG00000034249; ENSCATG00000017467; ENSCCAG00000029449; ENSCJAG00000013036; ENSCSAG00000013017; ENSG00000136518; ENSGGOG00000015710; ENSMFAG00000030153; ENSMMUG00000009742; ENSPANG00000024431; ENSPPAG00000031814; ENSPTRG00000023973; ENSRBIG00000036584; ENSRROG00000035215","Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; UCH proteinases; HATs acetylate histones; DNA Damage Recognition in GG-NER","Thermogenesis; Hepatocellular carcinoma",3259.1,2856.5,2994.7,3284.3,3099.5,3214.4,0.94916755224938,-0.0752653127384,0.27851582603666225,0.5551501219799716,0.5095247351673521,0.2928347280737686,4268]
["High","O96028-1","Histone-lysine N-methyltransferase NSD2 [OS=Homo sapiens]",17,19,38,19,1365,152.2,8.69,80.41,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD2","ENSG00000109685","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Lysine degradation; Metabolic pathways; Transcriptional misregulation in cancer",1519.2,1480.8,1549.1,1828.4,1795.9,1872.4,0.8276056543016719,-0.27298459298920386,4.4259485732946381E-4,3.353993636604901,0.018579465838862653,1.7309667761641818,186]
["High","P00167-1","Cytochrome b5 [OS=Homo sapiens]",39,4,9,4,134,15.3,4.96,29.2,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","CYB5A","ENSG00000166347; ENSPTRG00000010111","Oxidation by cytochrome P450","Vitamin C (ascorbate) metabolism","",312.8,359.8,311.5,387.6,324.3,333.1,0.9417224880382776,-0.08662611372878347,0.4686722596670902,0.32913075125905583,0.6818321228769593,0.16632254188745585,5367]
["High","P00338-1","L-lactate dehydrogenase A chain [OS=Homo sapiens]",72,24,204,21,332,36.7,8.27,395.17,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HEL-S-133P; LDHA","ENSG00000134333; ENSG00000288299","Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glycolysis and gluconeogenesis","Pyruvate metabolism","Glycolysis / Gluconeogenesis; Cysteine and methionine metabolism; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer",6270.2,6722.7,7201.6,6096.8,6986.4,6686,1.0215132630556623,0.030707935760236265,0.7245596894892392,0.13992583138257966,0.8583465415766923,0.06633733836411707,6591]
["High","P00367","Glutamate dehydrogenase 1, mitochondrial [OS=Homo sapiens]",48,24,107,10,558,61.4,7.8,248.82,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","GLUD1","ENSG00000148672","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension","Transcriptional activation of mitochondrial biogenesis; Glutamate and glutamine metabolism","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Nitrogen metabolism; Metabolic pathways; Carbon metabolism; Necroptosis; Proximal tubule bicarbonate reclamation",4683.6,4458.8,4321.7,4488.7,4522.5,4612.7,0.9882706126733168,-0.017021953781055556,0.6585953201616117,0.18138135961744417,0.8158515405079905,0.08838886208442383,6303]
["High","P00374","dihydrofolate reductase [OS=Homo sapiens]",38,6,19,6,187,21.4,7.42,30.46,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;mitochondrion","nucleic acid binding activity;other molecular function","DHFR","ENSG00000228716","Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Ethanol effects on histone modifications; Nucleotide metabolism","G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","One carbon pool by folate; Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance",567.7,562.3,542.9,640.1,602.8,606.7,0.9044658304498269,-0.1448620941654968,0.013712870166776584,1.8628716358643698,0.09611318694990266,1.0172170220434444,1114]
["High","P00387","NADH-cytochrome b5 reductase 3 [OS=Homo sapiens]",46,13,43,13,301,34.2,7.59,99.19,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CYB5R3","ENSG00000100243","Oxidation by cytochrome P450","Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism","Amino sugar and nucleotide sugar metabolism",1576.3,1477.9,1739.6,1539.7,1684.5,1618.8,0.9898410076398926,-0.014731282735782648,0.859725951652949,0.06563996346813915,0.9316780333804615,0.03073414395951187,7205]
["High","P00390","Glutathione reductase, mitochondrial [OS=Homo sapiens]",48,18,57,17,522,56.2,8.5,129.23,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","other molecular function","GSR","ENSG00000104687","Glutathione metabolism; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II","","Glutathione metabolism; Metabolic pathways; Thyroid hormone synthesis; Diabetic cardiomyopathy",1997,2079.1,2024.2,1934.1,2045.8,2084.6,1.0059032071893808,0.00849148881521628,0.8270399198207141,0.08247352728005897,0.9158314698567772,0.03818443729846602,7051]
["High","P00403","Cytochrome c oxidase subunit 2 [OS=Homo sapiens]",28,5,19,5,227,25.5,4.82,32.11,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO2","ENSG00000198712","Electron transport chain: OXPHOS system in mitochondria; Endothelin pathways; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly; CCL18 signaling pathway","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",941.6,997,950.9,882.4,893.4,906.6,1.0772069788249328,0.10729548166918051,0.020276459217640447,1.6930078815131047,0.11649638967721604,0.9336875335869637,1359]
["High","P00441","Superoxide dismutase [Cu-Zn] [OS=Homo sapiens]",92,14,102,14,154,15.9,6.13,283.23,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SOD1","ENSG00000142168","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species","Peroxisome; Longevity regulating pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis",5814.5,3814.2,3796.5,3800.6,3553.4,3814.9,1.2020163131552795,0.2654564757067692,0.3276748876032123,0.4845568408674141,0.560211412832468,0.25164804781577926,4567]
["High","P00488","Coagulation factor XIII A chain [OS=Homo sapiens]",7,4,7,4,732,83.2,6.09,10.39,"protein metabolism;other metabolic processes;stress response","non-structural extracellular;other cell component","other molecular function","F13A1","ENSG00000124491","Complement system","Platelet degranulation ; Interleukin-4 and Interleukin-13 signaling; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades; Coronavirus disease",239.5,213.8,227,233.4,236,253.1,0.94159169550173,-0.0868264985034695,0.21889562793581696,0.6597629126317548,0.4440470415491969,0.3525710190677103,3849]
["High","P00491","purine nucleoside phosphorylase [OS=Homo sapiens]",83,19,70,19,289,32.1,6.95,202.75,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PNP","ENSG00000198805","VEGFA-VEGFR2 signaling pathway","Neutrophil degranulation; Purine catabolism; Purine salvage","Purine metabolism; Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways",2893.8,2871.8,3317.6,2672.4,3209.9,2899,1.0343798754170797,0.04876611189420386,0.6610534771025249,0.1797634060648845,0.8168231601861868,0.08787195677023718,6319]
["High","P00492","Hypoxanthine-guanine phosphoribosyltransferase [OS=Homo sapiens]",42,6,24,6,218,24.6,6.68,36.92,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HPRT1","ENSG00000165704","Mesodermal commitment pathway; Nucleotide metabolism","Purine salvage","Purine metabolism; Drug metabolism; Metabolic pathways",247.8,283.4,264.8,318.7,290.7,303.5,0.8719465439807207,-0.19768840380474098,0.040807155006030035,1.3892636823218474,0.16975080782476426,0.7701881502845583,1877]
["High","P00505","Aspartate aminotransferase, mitochondrial [OS=Homo sapiens]",53,20,119,20,430,47.5,9.01,261.14,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","other molecular function","GOT2","ENSG00000125166","Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis","Glyoxylate metabolism and glycine degradation; Gluconeogenesis; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Cysteine and methionine metabolism; Arginine and proline metabolism; Tyrosine metabolism; Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Fat digestion and absorption",5431,5630.1,5697.8,5472.1,5644.8,5794.4,0.9909882741125754,-0.013060108090857954,0.7003525779536298,0.15468326839999763,0.8432309836024582,0.07405344416146115,6485]
["High","P00519-2","Isoform IB of Tyrosine-protein kinase ABL1 [OS=Homo sapiens]",12,9,13,9,1149,124.9,8.84,29.2,"","","","ABL1","","","","",495.5,468.6,530.9,516,521.1,498.5,0.9735608231310238,-0.038656980874119666,0.521711450211682,0.2825696315368161,0.7225120615914886,0.1411548984137642,5638]
["High","P00533-1","epidermal growth factor receptor [OS=Homo sapiens]",12,9,10,9,1210,134.2,6.68,20.89,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function","EGFR","ENSG00000146648","Androgen receptor signaling pathway; Glioblastoma signaling pathways; AGE/RAGE pathway; Gastric cancer network 2; Spinal cord injury; Aryl hydrocarbon receptor pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Bladder cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; ERK pathway in Huntington's disease; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Extracellular vesicles in the crosstalk of cardiac cells; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Regulatory circuits of the STAT3 signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway","Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF/MAP kinase cascade; Cargo recognition for clathrin-mediated endocytosis; HCMV Early Events; NOTCH3 Activation and Transmission of Signal to the Nucleus; Signaling by ERBB4; SHC1 events in ERBB2 signaling; GRB2 events in ERBB2 signaling; PI3K events in ERBB2 signaling; ERBB2 Regulates Cell Motility; ERBB2 Activates PTK6 Signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Signal transduction by L1; GRB2 events in EGFR signaling; GAB1 signalosome; SHC1 events in EGFR signaling; EGFR downregulation; EGFR interacts with phospholipase C-gamma; Inhibition of Signaling by Overexpressed EGFR; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PLCG1 events in ERBB2 signaling; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; PTK6 promotes HIF1A stabilization; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors; Signaling by ERBB2 ECD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Calcium signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; Endocytosis; PI3K-Akt signaling pathway; Focal adhesion; Adherens junction; Gap junction; JAK-STAT signaling pathway; Regulation of actin cytoskeleton; GnRH signaling pathway; Estrogen signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Epithelial cell signaling in Helicobacter pylori infection; Shigellosis; Hepatitis C; Human cytomegalovirus infection; Human papillomavirus infection; Coronavirus disease; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer",238.3,228.2,230.7,258.4,259.9,286.3,0.8665175242356451,-0.206699168499945,0.020009240103572683,1.698769404371871,0.11624415679218417,0.9346288684310421,1344]
["High","P00558","phosphoglycerate kinase 1 [OS=Homo sapiens]",78,30,422,25,417,44.6,8.1,981.27,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol","kinase activity;other molecular function","PGK1","ENSG00000102144","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glycolysis and gluconeogenesis","Gluconeogenesis; Glycolysis; Manipulation of host energy metabolism","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway",19421.9,19805,19542.3,19444.8,19104.5,19412.6,1.013928114847857,0.019955372233990826,0.16107821874892223,0.7929631815962128,0.37089316779462833,0.43075116671566377,3391]
["High","P00568","Adenylate kinase isoenzyme 1 [OS=Homo sapiens]",48,9,23,9,194,21.6,8.63,54.93,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK1","ENSG00000106992","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors",1291.9,1251.3,1240.8,1275.1,1262,1287.3,0.9894362514381341,-0.015321336272251797,0.47761985992519107,0.32091762309183713,0.6890716678299874,0.1617356063587871,5412]
["High","P00734","Prothrombin [OS=Homo sapiens]",5,2,5,2,622,70,5.9,5.85,"protein metabolism;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","F2","ENSG00000180210","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; IL1 and megakaryocytes in obesity; Regulation of actin cytoskeleton; Complement and coagulation cascades","Cell surface interactions at the vascular wall; Regulation of Complement cascade; G alpha (q) signalling events; Peptide ligand-binding receptors; Thrombin signalling through proteinase activated receptors (PARs); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Defective F8 cleavage by thrombin; Gamma-carboxylation of protein precursors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Platelet Aggregation (Plug Formation); Defective factor XII causes hereditary angioedema","Phospholipase D signaling pathway; Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Platelet activation; Regulation of actin cytoskeleton; Pathogenic Escherichia coli infection; Coronavirus disease; Pathways in cancer",64.8,64.4,67,64.7,62.4,62.2,1.0364500792393025,0.05165063051553333,0.11352042399153622,0.9449259954853896,0.30490797059714997,0.515831222597182,2907]
["High","P00747","Plasminogen [OS=Homo sapiens]",5,4,13,4,810,90.5,7.24,18.2,"cell organization and biogenesis;protein metabolism;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLG","ENSG00000122194","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; Complement system; Fibrin complement receptor 3 signaling pathway; Complement and coagulation cascades","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by PDGF; Platelet degranulation ; Activation of Matrix Metalloproteinases; Dissolution of Fibrin Clot","Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Staphylococcus aureus infection; Influenza A",667.1,496.9,706.8,611,672.5,643.3,{"$f":"AVERAGE(T962:V962)/AVERAGE(W962:Y962)","v":0.9709362673863401},{"$f":"LOG(Z962,2)","v":-0.04255149516803635},{"$f":"TTEST(T962:V962,W962:Y962,2,2)","v":0.7937104660490634},{"$f":"-LOG10(AB962)","v":0.10033789294951442},{"$f":"AB962*7808/AF962","v":0.8947865028748321},{"$f":"-LOG10(AD962)","v":0.048280575504321036},6926]
["High","P00750-1","Tissue-type plasminogen activator [OS=Homo sapiens]",5,2,2,2,562,62.9,7.8,5.04,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;other molecular function","PLAT","ENSG00000104368","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; NOTCH1 regulation of endothelial cell calcification; Fibrin complement receptor 3 signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Complement and coagulation cascades","Signaling by PDGF; Dissolution of Fibrin Clot","Apelin signaling pathway; Complement and coagulation cascades; Transcriptional misregulation in cancer; Prostate cancer; Fluid shear stress and atherosclerosis",53.5,58.9,52.5,72.1,62.5,67.9,0.814320987654321,-0.29633050922188225,0.021415897422124516,1.6692637220000544,0.11943951933710588,0.9228519530196571,1400]
["High","P00813","adenosine deaminase [OS=Homo sapiens]",25,6,9,6,363,40.7,5.95,14.19,"cell adhesion;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ADA","ENSG00000196839","","Purine salvage","Purine metabolism; Metabolic pathways; Primary immunodeficiency",414.4,430.5,454.1,430.3,445,414,1.0075234623439075,0.010813435391532145,0.8355410202561722,0.07803222388717772,0.9200259887406842,0.03619990460307961,7091]
["High","P00846","ATP synthase subunit A [OS=Homo sapiens]",4,1,5,1,226,24.8,10.1,12.85,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ATP6","ENSG00000198899","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",337.4,339.3,366.5,262,308.2,326.8,1.1629877369007804,0.217835884424454,0.08538581651807955,1.0686142641998513,0.2571124008380892,0.5898769763105673,2593]
["High","P00918","Carbonic anhydrase 2 [OS=Homo sapiens]",13,3,4,3,260,29.2,7.4,8.46,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CA2","ENSG00000104267","Proximal tubule transport","Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Nitrogen metabolism; Metabolic pathways; Proximal tubule bicarbonate reclamation; Collecting duct acid secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion",180.2,181.2,181.8,173.1,164.2,169.9,1.070977917981073,0.09892873410532514,0.01051233200850264,1.978300931347492,0.08307721490120305,1.0805180712764848,988]
["High","P00966","Argininosuccinate synthase [OS=Homo sapiens]",19,8,18,8,412,46.5,8.02,33.05,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASS1","ENSG00000130707","Alanine and aspartate metabolism; Amino acid metabolism","Urea cycle","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids; Fluid shear stress and atherosclerosis",948.6,888.5,952.9,883.6,910.6,900.2,1.035480997624703,0.05030107853751611,0.22491311779670822,0.6479852141037773,0.45179357441643886,0.3450599500764083,3887]
["High","P01023","alpha-2-macroglobulin [OS=Homo sapiens]",5,8,58,8,1474,163.2,6.46,101.45,"other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","A2M","ENSG00000175899","Complement system; Complement and coagulation cascades","Degradation of the extracellular matrix; Platelet degranulation ; HDL assembly; Intrinsic Pathway of Fibrin Clot Formation","Complement and coagulation cascades",1791.6,1804.2,2025,1617.2,1657.5,2054,1.0548163717229344,0.07699186844650056,0.5725689273462196,0.24217222433439697,0.7599215000372739,0.11923126806320805,5883]
["High","P01024","Complement C3 [OS=Homo sapiens]",1,2,4,2,1663,187,6.4,5.7,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","C3","ENSG00000125730","Allograft rejection; Complement system; TYROBP causal network in microglia; Cells and molecules involved in local acute inflammatory response ; 16p11.2 distal deletion syndrome; Complement system in neuronal development and plasticity; Acquired partial lipodystrophy / Barraquer-Simons syndrome; Complement activation; Complement and coagulation cascades","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; G alpha (i) signalling events; Neutrophil degranulation; Peptide ligand-binding receptors; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Purinergic signaling in leishmaniasis infection; Alternative complement activation; Activation of C3 and C5","Neuroactive ligand-receptor interaction; Phagosome; Complement and coagulation cascades; Neutrophil extracellular trap formation; Alcoholic liver disease; Shigellosis; Pertussis; Legionellosis; Leishmaniasis; Chagas disease; Staphylococcus aureus infection; Tuberculosis; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Coronavirus disease; Viral carcinogenesis; Systemic lupus erythematosus",43.7,44.3,39.3,36.4,48,56.1,0.9060498220640568,-0.14233771120693073,0.4993009909530142,0.3016375720081812,0.7052355530682227,0.15166580171568778,5528]
["High","P01033","Metalloproteinase inhibitor 1 [OS=Homo sapiens]",10,2,2,2,207,23.2,8.1,4.81,"stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","TIMP1","ENSG00000102265","Matrix metalloproteinases; Mammary gland development pathway - Puberty (Stage 2 of 4); IL1 and megakaryocytes in obesity; Lung fibrosis; IL-6 signaling pathway; IL-18 signaling pathway; Burn wound healing; CCL18 signaling pathway","Interleukin-4 and Interleukin-13 signaling; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-10 signaling; Activation of Matrix Metalloproteinases","HIF-1 signaling pathway",114.6,107.6,121.3,117.3,126.9,114.7,0.957091111730287,-0.06327182411061491,0.3974413163078395,0.4007269874732773,0.6257757204540454,0.2035812911057518,4959]
["High","P01034","Cystatin-C [OS=Homo sapiens]",12,1,1,1,146,15.8,8.75,0,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CST3","ENSG00000101439","","Neutrophil degranulation; Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Salivary secretion",32.7,32.3,30.4,33,36.3,23.5,1.0280172413793103,0.03986446087793932,0.8351027685579064,0.07826007652683882,0.9199326208944884,0.03624398074719776,7088]
["High","P01111","GTPase NRas [OS=Homo sapiens]",69,10,37,3,189,21.2,5.17,55.68,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","NRAS","ENSG00000213281","Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling","Neutrophil degranulation; FCERI mediated MAPK activation; Regulation of RAS by GAPs; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",1286.9,1231.5,1321.1,1239.3,1346.8,1281.1,0.9928371948696731,-0.010370930417423286,0.8318460752188629,0.07995702811736988,0.9186780983463765,0.03683663725563387,7070]
["High","P01112","GTPase HRas [OS=Homo sapiens]",55,8,36,1,189,21.3,5.31,57.96,"stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","HRAS","ENSG00000174775; ENSG00000276536","Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; Pathways affected in adenoid cystic carcinoma; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; IL-2 signaling pathway; Malignant pleural mesothelioma; Alzheimer's disease; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling","Regulation of RAS by GAPs; EPHB-mediated forward signaling; FCERI mediated MAPK activation; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Focal adhesion; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Salmonella infection; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",60.7,68.3,45.4,70.2,66.2,48.9,0.9411764705882352,-0.0874628412503396,0.7183524365701217,0.1436624308215078,0.8539731767264784,0.06855577027425677,6568]
["High","P01116-2","Isoform 2B of GTPase KRas [OS=Homo sapiens]",62,9,38,3,188,21.4,8.12,58.59,"","","","KRAS","","","","",475.1,477.5,435.7,524.9,520,465.6,0.9190996358821582,-0.1217068281484185,0.15587885022502426,0.807212806258671,0.36385711885111793,0.4390691237038775,3345]
["High","P01130","Low-density lipoprotein receptor [OS=Homo sapiens]",10,8,10,8,860,95.3,5.05,17.03,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LDLR","ENSG00000130164","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M signaling pathway; PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Lipid particles composition; Wnt signaling pathway and pluripotency; Statin inhibition of cholesterol production; Bile acids synthesis and enterohepatic circulation ; Metabolic pathway of LDL, HDL and TG, including diseases; Orexin receptor pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; DNA damage response (only ATM dependent)","Cargo recognition for clathrin-mediated endocytosis; Retinoid metabolism and transport; LDL clearance; Chylomicron clearance","Endocytosis; Ovarian steroidogenesis; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Cushing syndrome; Bile secretion; Cholesterol metabolism; Toxoplasmosis; Hepatitis C; Lipid and atherosclerosis",372.2,367,371.4,666.7,667.6,713.6,0.5423116363103667,-0.8828059684819562,3.6398430800936055E-5,4.438917339130737,0.006931681651066067,2.1591613911918373,41]
["Medium","P01350","Gastrin [OS=Homo sapiens]",16,1,1,1,101,11.4,5.19,0,"signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","GAST","ENSG00000184502","Gastrin signaling pathway","Gastrin-CREB signalling pathway via PKC and MAPK","Gastric acid secretion",23.6,20.6,23.5,19.7,17.9,19.8,1.1794425087108016,0.2381050968993092,0.041713212877281705,1.3797263581969246,0.17214416815317948,0.7641076856040631,1892]
["Low","P01563","Interferon alpha-2 [OS=Homo sapiens]",10,1,1,1,188,21.5,6.76,0,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","IFNA2","ENSG00000188379","PI3K-Akt signaling pathway; Overview of interferons-mediated signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; SARS coronavirus and innate immunity; Overview of proinflammatory and profibrotic mediators; Type II interferon signaling (IFNG); Toll-like receptor signaling pathway","Factors involved in megakaryocyte development and platelet production; Regulation of IFNA signaling; TRAF6 mediated IRF7 activation","Cytokine-cytokine receptor interaction; PI3K-Akt signaling pathway; Necroptosis; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Alcoholic liver disease; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Autoimmune thyroid disease; Lipid and atherosclerosis",60.1,54.7,38.7,65.2,35.5,56.5,0.9764631043256997,-0.03436256200106477,0.91542847912398,0.03837558072890537,0.9562094401337841,0.019446973066737205,7475]
["High","P01834","immunoglobulin kappa constant [OS=Homo sapiens]",19,1,1,1,107,11.8,6.52,2.75,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGKC","","","FCERI mediated NF-kB activation; Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers","",13.2,15.8,10.7,20.9,10,15.3,0.8593073593073594,-0.2187538442730997,0.5666776284878275,0.24666393226068906,0.7556992183147664,0.12165102701043562,5855]
["Medium","P01854","immunoglobulin heavy constant epsilon [OS=Homo sapiens]",4,1,1,1,428,47,8.06,0,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHE","ENSG00000211891; ENSG00000276192","","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; Interleukin-4 and Interleukin-13 signaling","",47.7,52.8,48.4,44.1,40.9,46.7,1.1305998481397115,0.17708840832558553,0.06849209023762569,1.1643595798141235,0.2243230874896734,0.6491260262236869,2384]
["High","P02042","Hemoglobin subunit delta [OS=Homo sapiens]",13,2,12,2,147,16,8.05,25.21,"other metabolic processes;transport;other biological processes","cytosol;other cell component","other molecular function","HBD","ENSG00000223609","VEGFA-VEGFR2 signaling pathway","Factors involved in megakaryocyte development and platelet production","",395.9,407,375.8,306.1,312.5,383,1.1768170926517572,0.2348901062472245,0.08795009200759304,1.055763701876002,0.26120742426598953,0.5830144833237293,2629]
["High","P02452","Collagen alpha-1(I) chain [OS=Homo sapiens]",9,11,16,11,1464,138.9,5.8,18.87,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi;other cell component","extracellular structural activity;other molecular function","COL1A1","ENSG00000108821","Focal adhesion; Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miR-509-3p alteration of YAP1/ECM axis; PI3K-Akt signaling pathway; Inflammatory response pathway; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Angiotensin II receptor type 1 pathway; Burn wound healing; CCL18 signaling pathway; NRP1-triggered signaling pathways in pancreatic cancer","GPVI-mediated activation cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Collagen degradation; Integrin cell surface interactions; ECM proteoglycans; Collagen chain trimerization; Syndecan interactions; MET activates PTK2 signaling; RUNX2 regulates osteoblast differentiation; Anchoring fibril formation; Crosslinking of collagen fibrils; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); Scavenging by Class A Receptors; GP1b-IX-V activation signalling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Platelet activation; Relaxin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Protein digestion and absorption; Amoebiasis; Human papillomavirus infection; Proteoglycans in cancer; Diabetic cardiomyopathy",209.7,303.4,338.1,282.2,258.2,439,0.8691035327751684,-0.20240004520757657,0.5662367312646946,0.24700196176682343,0.7554983591446917,0.12176647456146128,5852]
["High","P02458-1","Isoform 1 of Collagen alpha-1(II) chain [OS=Homo sapiens]",3,4,4,4,1418,134.3,8.56,4.78,"","","","COL2A1","","","","",63.8,84,97.1,99.2,55.2,112.1,0.9189493433395873,-0.12194275908255993,0.7340309154775243,0.13428564834203952,0.8635397601398991,0.06371766132544689,6637]
["High","P02462","Collagen alpha-1(IV) chain [OS=Homo sapiens]",2,3,6,3,1669,160.5,8.28,20.23,"","","","","","","","",140.5,136.3,140.9,123.4,129.2,146.8,1.0458187280921383,0.06463281071882025,0.44386424502969646,0.35274983765477347,0.6618968726493258,0.1792096708748562,5236]
["High","P02533","Keratin, type I cytoskeletal 14 [OS=Homo sapiens]",39,20,65,5,472,51.5,5.16,146.33,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KRT14","ENSG00000186847","Corticotropin-releasing hormone signaling pathway","Formation of the cornified envelope; Type I hemidesmosome assembly","Estrogen signaling pathway; Staphylococcus aureus infection",1249.8,869.2,1286.8,1423.9,1319.6,1787.3,0.7516994791206851,-0.4117720907462746,0.12637974187748022,0.8983225359897589,0.3233201260089664,0.4903672606139663,3052]
["High","P02538","Keratin, type II cytoskeletal 6A [OS=Homo sapiens]",34,21,119,2,564,60,8,216.7,"cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6A","ENSG00000205420","Ectoderm differentiation; Ectoderm differentiation","Formation of the cornified envelope","",431.2,327.6,402.6,506,488.1,854.8,0.6281572827086376,-0.6708022577870765,0.13660645113369638,0.8645287909501564,0.33796678404686353,0.4711259808289037,3156]
["High","P02545","Prelamin-A/C [OS=Homo sapiens]",65,49,228,46,664,74.1,7.02,519.2,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LMNA","ENSG00000160789","Arrhythmogenic right ventricular cardiomyopathy; Adipogenesis; Fas ligand pathway and stress induction of heat shock proteins; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome","XBP1(S) activates chaperone genes; Signaling by BRAF and RAF1 fusions","Apoptosis; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy",9175,9532.9,8910.7,6639,6383.9,6641.5,1.4044974675047295,0.4900540230960936,1.8532858598361676E-4,3.732057587818497,0.013154959994182543,1.880910468318087,110]
["High","P02647","Apolipoprotein A-I [OS=Homo sapiens]",8,2,10,1,267,30.8,5.76,21.78,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","APOA1","ENSG00000118137","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5","PPARA activates gene expression; Platelet degranulation ; Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging of heme from plasma; Scavenging by Class B Receptors; Heme signaling; Retinoid metabolism and transport; HDL clearance; Defective ABCA1 causes TGD; HDL assembly; Scavenging by Class A Receptors; ABC transporters in lipid homeostasis; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","PPAR signaling pathway; Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; African trypanosomiasis; Lipid and atherosclerosis",125.6,89.9,134.9,86.1,92.6,104.5,1.2372881355932204,0.307181509518176,0.20310880614350654,0.6922712465773576,0.42414377062543435,0.37248690707294185,3739]
["High","P02649","Apolipoprotein E [OS=Homo sapiens]",64,18,94,18,317,36.1,5.73,206.13,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","APOE","ENSG00000130203","Vitamin B12 metabolism; Alzheimer's disease and miRNA effects; Apoptosis-related network due to altered Notch3 in ovarian cancer; ApoE and miR-146 in inflammation and atherosclerosis; Statin inhibition of cholesterol production; Familial hyperlipidemia type 3; Alzheimer's disease","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Retinoid metabolism and transport; Nuclear signaling by ERBB4; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors","Cholesterol metabolism; Alzheimer disease",3563.5,4105.9,3760.8,3357.4,3328.3,3418.9,1.1311877758644577,0.1778384349178213,0.051427288261765375,1.2888063752317145,0.19148510574528568,0.7178650010384228,2097]
["High","P02671-1","Fibrinogen alpha chain [OS=Homo sapiens]",2,3,10,3,866,94.9,6.01,16.25,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGA","ENSG00000171560","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway","Regulation of TLR by endogenous ligand; Platelet degranulation ; Integrin cell surface interactions; Amyloid fiber formation; ER-Phagosome pathway; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease",148.6,146,203.2,154.5,125.1,251,0.9381831888428195,-0.09205844524765999,0.8090286381357241,0.09203610488440997,0.9059078741666046,0.042915965430692884,6973]
["High","P02675","Fibrinogen beta chain [OS=Homo sapiens]",11,7,61,7,491,55.9,8.27,96.62,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGB","ENSG00000171564","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway; Complement and coagulation cascades","Platelet degranulation ; Common Pathway of Fibrin Clot Formation; ER-Phagosome pathway; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease",728.4,689.6,959.8,754.9,658,1084,0.9523008530577917,-0.07051066983527611,0.8093615291245085,0.09185744250191655,0.9060207626385897,0.042861849788916294,6975]
["High","P02679","Fibrinogen gamma chain [OS=Homo sapiens]",7,3,26,3,453,51.5,5.62,46.62,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGG","ENSG00000171557","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway","ER-Phagosome pathway; Platelet degranulation ; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Staphylococcus aureus infection; Coronavirus disease",371.3,337.3,428.3,347.7,368.9,457.6,0.968233691023676,-0.04657279925591872,0.7862115820016308,0.10446056270068162,0.8907051700912264,0.05026602681803715,6892]
["High","P02748","complement component C9 [OS=Homo sapiens]",4,2,4,2,559,63.1,5.59,2.69,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes","","C9","ENSG00000113600","Allograft rejection; Complement system; Complement system in neuronal development and plasticity; Complement activation; Complement and coagulation cascades","Regulation of Complement cascade; Terminal pathway of complement","Complement and coagulation cascades; Prion disease; Amoebiasis; Coronavirus disease; Systemic lupus erythematosus",110.8,96.8,110.3,90.6,102.4,93.5,1.1095986038394414,0.1500378774937087,0.14541791386921782,0.837382089932738,0.3505474132420045,0.4552532332842796,3239]
["Medium","P02749","Beta-2-glycoprotein 1 [OS=Homo sapiens]",3,1,1,1,345,38.3,7.97,1.61,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;other cell component","enzyme regulator activity;other molecular function","APOH","ENSG00000091583","","Platelet degranulation","Cholesterol metabolism",48,48.9,49,45.4,39.5,51,1.0735835172921264,0.10243442715049944,0.3741584068729032,0.42694449227578735,0.6051012512145045,0.21817194904246356,4828]
["High","P02751","fibronectin [OS=Homo sapiens]",30,55,452,55,2386,262.5,5.71,976.91,"","","","","","","","",6513.4,7207.5,8100.9,6481.7,6159.6,9166.5,1.0006419721384092,9.2587285996995115E-4,0.9966922861969212,1.4389029059845339E-3,0.997970424548033,8.8232909931603028E-4,7798]
["Medium","P02753","Retinol-binding protein 4 [OS=Homo sapiens]",4,1,1,1,201,23,6.07,1.6,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other cell component","transporter activity;other molecular function","RBP4","ENSG00000138207","Sterol regulatory element-binding proteins (SREBP) signaling; Vitamin A and carotenoid metabolism","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events; Retinoid metabolism disease events","",43.1,40.9,38.7,48.5,41.8,34.8,0.9808153477218227,-0.02794654050291462,0.8566701016059152,0.06718639002007543,0.9309506128516334,0.031073357831684474,7185]
["Medium","P02760","Protein AMBP [OS=Homo sapiens]",2,1,3,1,352,39,6.25,0,"cell adhesion;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","AMBP","ENSG00000106927","","Scavenging of heme from plasma","",98.9,95.2,113.1,104.8,102.7,104.9,0.9833546734955189,-0.024216237420822705,0.7685049400168236,0.11435333647243191,0.8824244958310822,0.0543224445200328,6800]
["High","P02765","Alpha-2-HS-glycoprotein [OS=Homo sapiens]",7,4,33,4,367,39.3,5.72,45.09,"","","","","","","","",1503.9,1366.1,1469.3,1270.7,1377.5,1374,1.0788374521406197,0.10947751111298354,0.12305628464059129,0.9098962014245531,0.31889262212868796,0.4963555284392748,3013]
["High","P02768-1","Serum albumin [OS=Homo sapiens]",8,6,55,6,609,69.3,6.28,93.09,"stress response;other biological processes","non-structural extracellular;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","ALB","ENSG00000163631","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; VEGFA-VEGFR2 signaling pathway","Cytoprotection by HMOX1; Scavenging of heme from plasma; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Recycling of bile acids and salts; Heme degradation; HDL remodeling; Heme biosynthesis","Thyroid hormone synthesis",2127.5,2151.7,2178.7,2162.9,2159.5,2182.2,0.9928204655167113,-0.010395240100846935,0.3960146192450607,0.4022887813970449,0.6242847056461608,0.20461730472086548,4953]
["High","P02771","Alpha-fetoprotein [OS=Homo sapiens]",3,2,3,2,609,68.6,5.68,8.34,"other metabolic processes;developmental processes;signal transduction","non-structural extracellular;ER/Golgi;other cell component","other molecular function","AFP","ENSG00000081051","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Hippo signaling pathway",126,98.3,99.8,110.5,131.4,122.1,0.8903846153846156,-0.16749942976821786,0.2869999065893496,0.5421182446170064,0.5184857174108379,0.2852632025055935,4322]
["High","P02774","vitamin D-binding protein [OS=Homo sapiens]",10,4,11,4,474,52.9,5.54,34.45,"transport","non-structural extracellular","transporter activity;cytoskeletal activity;other molecular function","HEL-S-51","","","","",246.2,254,236.3,242.8,250.6,256.7,0.9818690841221172,-0.0263974168633629,0.5246889883387444,0.28009805025544926,0.7240670945473517,0.14022118871778594,5658]
["High","P02792","Ferritin light chain [OS=Homo sapiens]",40,6,15,6,175,20,5.78,39.57,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTL","ENSG00000087086","Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Ferroptosis; Necroptosis; Mineral absorption",703.2,779.4,679.3,377.4,411.5,408.8,1.8050429990815726,0.8520332048813434,5.5967057149189489E-4,3.2520675284956098,0.02111066580777157,1.6754980692938923,207]
["High","P03905","NADH-ubiquinone oxidoreductase chain 4 [OS=Homo sapiens]",6,2,2,2,459,51.5,9.35,2.5,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-ND4","ENSG00000198886","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",73.1,98.4,117.6,90.2,113.9,101.8,0.9450800915331807,-0.08149149808115308,0.7206386188139773,0.14228246787484594,0.8559090866594973,0.06757236296181607,6574]
["High","P04062","glucosylceramidase [OS=Homo sapiens]",6,3,3,3,536,59.7,7.61,8.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GBA","ENSG00000177628","Sphingolipid pathway","Glycosphingolipid metabolism; Association of TriC/CCT with target proteins during biosynthesis","Other glycan degradation; Sphingolipid metabolism; Metabolic pathways; Lysosome",180.5,209.4,183.9,169.7,186,196.1,1.0398695179412831,0.05640251141539151,0.5719879022512562,0.2426131565934869,0.7599253940408045,0.1192290426492503,5877]
["Medium","P04150","Glucocorticoid receptor [OS=Homo sapiens]",1,1,1,1,777,85.6,6.38,2.62,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","NR3C1","ENSG00000113580","Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling","Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression","Neuroactive ligand-receptor interaction",46.2,33.7,36.5,45.1,41.8,43.6,0.8919540229885058,-0.16495874854896292,0.2951661521533556,0.529933446225144,0.5275022467414513,0.2777756862760771,4369]
["Medium","P04437","T-cell receptor alpha chain V region CTL-L17 [OS=Homo sapiens]",5,1,1,1,139,15.4,8.43,2.06,"","","","","","","","",78.3,62.3,101.7,85.5,96.3,69.5,0.9641862315957024,-0.052616266429308965,0.838976368527768,0.07625027178456266,0.9221181708143037,0.03521341989647182,7104]
["High","P04733","Metallothionein-1F [OS=Homo sapiens]",33,2,13,1,61,6.1,7.83,22.3,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1F","ENSG00000198417","Copper homeostasis; Zinc homeostasis","Metallothioneins bind metals","Mineral absorption",803.5,692.7,587,628.3,656.6,661.2,1.0704485894866655,0.0982155089661265,0.5105502355811338,0.29196151907696716,0.7136369923769231,0.146522645783318,5586]
["High","P04920-1","Anion exchange protein 2 [OS=Homo sapiens]",8,5,9,5,1241,136.9,6.29,19.31,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC4A2","ENSG00000164889","Proximal tubule transport","Bicarbonate transporters","Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion",131.2,128.2,111.6,131,112.3,143.3,0.9596482152095188,-0.05942245070307021,0.6576359566441345,0.18201444950507,0.815568861098698,0.08853936419744277,6296]
["High","P05067-8","Isoform APP751 of Amyloid-beta A4 protein [OS=Homo sapiens]",40,20,50,1,751,84.8,4.79,114.1,"","","","APP","","","","",21.8,17.8,17.5,23.1,22.9,22.4,0.834795321637427,-0.2605055795230549,0.05480397910965353,1.2611879078910269,0.19828983729757868,0.7026995435792832,2158]
["High","P05141","ADP/ATP translocase 2 [OS=Homo sapiens]",51,18,174,5,298,32.8,9.69,350.99,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","transporter activity;other molecular function","SLC25A5","ENSG00000005022","Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization","Calcium signaling pathway; cGMP-PKG signaling pathway; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Influenza A; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy",9363.2,9845.2,11128.5,8418.5,10021.8,9584,1.0825212404948565,0.11439533280970006,0.33964685935404143,0.4689723968881094,0.5719134521967555,0.24266968812527845,4637]
["High","P05387","60S acidic ribosomal protein P2 [OS=Homo sapiens]",70,5,26,5,115,11.7,4.54,87.36,"protein metabolism;other metabolic processes","cytosol;translational apparatus","other molecular function","RPLP2","ENSG00000177600","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",775.7,837.2,800.1,990.4,747.2,608.9,1.02834008097166,0.040317455187488416,0.8539585229344955,0.06856322263432313,0.9292973027278802,0.03184532338171765,7175]
["High","P05423","DNA-directed RNA polymerase III subunit RPC4 [OS=Homo sapiens]",29,9,25,9,398,44.4,6.98,52.77,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3D","ENSG00000168495","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",1122.8,1120.8,1137.3,1237.3,1295.4,1232.7,0.8978860147660275,-0.15539578618978508,0.003543418869575045,2.4505775064326567,0.04794976522294966,1.3192135149297526,577]
["High","P05937","Calbindin [OS=Homo sapiens]",15,2,4,2,261,30,4.83,6.53,"developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CALB1","ENSG00000104327","","Amyloid fiber formation","Endocrine and other factor-regulated calcium reabsorption",104,99.7,102.9,84.9,78.4,79.4,1.2632880098887516,0.3371835885076438,8.8644839165172567E-4,3.052346543620089,0.026827089310142146,1.571426444924684,258]
["High","P06280","alpha-galactosidase A [OS=Homo sapiens]",25,8,30,8,429,48.7,5.6,70.75,"other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","GLA","ENSG00000102393","Degradation pathway of sphingolipids, including diseases; Ciliary landscape","Neutrophil degranulation; Glycosphingolipid metabolism","Galactose metabolism; Glycerolipid metabolism; Sphingolipid metabolism; Glycosphingolipid biosynthesis; Metabolic pathways; Lysosome",967.4,974.9,991.2,982.8,958.3,966.8,1.0088036039753776,0.012645334851051564,0.44352652269552895,0.35308040443225236,0.6618989084875172,0.1792083350898278,5232]
["High","P06733-1","alpha-enolase [OS=Homo sapiens]",81,35,836,30,434,47.1,7.39,1693.12,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","ENO1; HEL-S-17; LOC117800423","ENSAMEG00000029491; ENSG00000074800; ENSGGOG00000010357; ENSPPAG00000003541; ENSPPYG00000001920; ENSPTRG00000000109","Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis","Gluconeogenesis; Glycolysis; Manipulation of host energy metabolism","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway",31161.9,31064.4,30116.7,29514.5,29461,29842.7,1.0396855599415435,0.05614726903448896,0.02941893623253154,1.5313730350991095,0.14049116458936162,0.852350987436779,1635]
["High","P06748","Nucleophosmin [OS=Homo sapiens]",63,19,563,19,294,32.6,4.78,1527.79,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","cytosol;cytoskeleton;translational apparatus;nucleus;other cell component","enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function","NPM1","ENSG00000181163","","TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Nuclear events stimulated by ALK signaling in cancer; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation","",18925,19486,17257.6,18037,16185.3,16103.7,1.1061598378571713,0.14555986714826602,0.1249772937493205,0.9031688837529577,0.32162910665612865,0.492644655545034,3034]
["High","P07093-1","Glia-derived nexin [OS=Homo sapiens]",14,4,10,4,398,44,9.29,19.88,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SERPINE2","ENSG00000135919","","Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Dissolution of Fibrin Clot","",309.3,306.6,344.5,247.7,237.6,267.6,1.2756010094302035,0.3511771443611468,0.010078653647354855,1.9965974790588563,0.08146390028835063,1.0890348008157142,966]
["High","P07355","Annexin A2 [OS=Homo sapiens]",69,30,235,30,339,38.6,7.75,501.76,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","ANXA2","ENSG00000182718","Gastrin signaling pathway; CCL18 signaling pathway; Prostaglandin synthesis and regulation","Smooth Muscle Contraction; Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Dissolution of Fibrin Clot","Salmonella infection",9792.3,10409.6,9639.4,8459.8,9124.8,8751.9,1.133077667875382,0.18024675543754562,0.01842636494153578,1.7345603317119993,0.1121380026995412,0.9502471834282924,1283]
["High","P07384","Calpain-1 catalytic subunit [OS=Homo sapiens]",54,34,124,33,714,81.8,5.67,250.54,"protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","CAPN1","ENSG00000014216","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease","Degradation of the extracellular matrix; Neutrophil degranulation; Formation of the cornified envelope; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Protein processing in endoplasmic reticulum; Apoptosis; Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis",5070,4644,5285.1,5104.8,5487,5287.8,0.9445515000377843,-0.0822986356759703,0.2500246119684292,0.6020172380641016,0.47988991402396636,0.3188583776561731,4068]
["High","P07741-1","Adenine phosphoribosyltransferase [OS=Homo sapiens]",83,12,86,12,180,19.6,6.02,171.04,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","APRT","ENSG00000198931; ENSPPAG00000005769; ENSPTRG00000008466","","Neutrophil degranulation; Purine salvage","Purine metabolism; Metabolic pathways",3417.9,3380.2,3386,3094.6,3223.5,3149.4,1.0756905202006866,0.10526306935068569,3.6493002815537008E-3,2.437790399376858,0.0482944688107988,1.316102606360367,590]
["High","P07951-1","Tropomyosin beta chain [OS=Homo sapiens]",58,26,115,6,284,32.8,4.7,216.72,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","TPM2","ENSANAG00000037556; ENSCANG00000042880; ENSCATG00000041575; ENSCCAG00000023807; ENSG00000198467; ENSMFAG00000002090; ENSMLEG00000037634; ENSMMUG00000016321; ENSMNEG00000031621; ENSNLEG00000004274; ENSPANG00000025431; ENSPPAG00000030835; ENSPTRG00000024321; ENSRBIG00000029128; ENSRROG00000041510; ENSSBOG00000021703","Striated muscle contraction pathway","Striated Muscle Contraction; Smooth Muscle Contraction","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Hypertrophic cardiomyopathy; Dilated cardiomyopathy",1476.9,1684.6,1320.3,1440.2,1306.6,1380.8,1.0858125787382498,0.11877510216658947,0.352659326217396,0.45264462657566634,0.5852420869512067,0.2326644496803067,4705]
["High","P08069","Insulin-like growth factor 1 receptor [OS=Homo sapiens]",9,10,16,9,1367,154.7,5.8,22.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;transporter activity;kinase activity;other molecular function","IGF1R","ENSG00000140443","MicroRNAs in cardiomyocyte hypertrophy; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Apoptosis; Focal adhesion; MECP2 and associated Rett syndrome; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Ebola virus infection in host; Ras signaling; Breast cancer pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Head and neck squamous cell carcinoma; Endochondral ossification; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Malignant pleural mesothelioma","Extra-nuclear estrogen signaling; IRS-related events triggered by IGF1R; Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R); SHC-related events triggered by IGF1R","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Oocyte meiosis; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Long-term depression; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Pathways in cancer; Transcriptional misregulation in cancer; Proteoglycans in cancer; Glioma; Prostate cancer; Melanoma; Breast cancer; Hepatocellular carcinoma",338.8,390.8,359.3,396.1,400.3,414.3,0.8993970430329562,-0.152969954052218,0.0651531771920617,1.1860644010820802,0.21767907895405125,0.6621833088156718,2337]
["High","P08195","4F2 cell-surface antigen heavy chain [OS=Homo sapiens]",37,19,75,19,630,68,5.01,176.48,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","transporter activity;nucleic acid binding activity;other molecular function","SLC3A2","ENSG00000168003","mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; Proximal tubule transport; Malignant pleural mesothelioma","Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)","mTOR signaling pathway; Ferroptosis; Protein digestion and absorption",3284,3343.4,3299.7,3082.2,3158.6,3177.6,1.0540112970355897,0.07589033005850393,0.007671445660303052,2.11512278688138,0.06948799038938078,1.1580902480474573,862]
["Medium","P08247","Synaptophysin [OS=Homo sapiens]",5,2,2,2,313,33.8,4.81,2.16,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SYP","ENSG00000102003","Synaptic vesicle pathway","Sensory processing of sound by inner hair cells of the cochlea","",94,92.8,93.6,78.9,80.6,77,1.1856236786469343,0.24564616578386544,1.8324230947330572E-4,3.736974243281065,0.013247740299699731,1.8778581941093797,108]
["High","P08473","Neprilysin [OS=Homo sapiens]",11,6,8,6,750,85.5,5.73,9.23,"protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","MME","ENSG00000196549","Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Alzheimer's disease","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","Renin-angiotensin system; Hematopoietic cell lineage; Protein digestion and absorption; Alzheimer disease",147,146.6,146.1,163.9,174.4,152.4,0.8960668432851029,-0.15832173885558012,0.05559498011549364,1.2549644207662,0.19967139132556316,0.6996841558578404,2174]
["High","P08621-1","U1 small nuclear ribonucleoprotein 70 kDa [OS=Homo sapiens]",50,20,154,20,437,51.5,9.94,380.18,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","SNRNP70; SNRP70","ENSCATG00000016149; ENSG00000104852; ENSGGOG00000008245; ENSMLEG00000030967; ENSPANG00000004068; ENSPPAG00000035067; ENSPTRG00000011277; ENSRROG00000033636","mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway","Spliceosome",6772.2,7331.8,6741.2,6971.2,6801.5,7071.6,1.0000431772714842,6.2290290696614907E-5,0.9989154820872207,4.7125573390290233E-4,0.999811829782979,8.1728976631570267E-5,7801]
["High","P08962","CD63 antigen [OS=Homo sapiens]",13,4,35,4,238,25.6,7.81,62.36,"cell adhesion;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","","CD63","ENSG00000135404","Extracellular vesicles in the crosstalk of cardiac cells","Neutrophil degranulation; Platelet degranulation","Lysosome; Proteoglycans in cancer",1989.4,2225.5,2110.7,1857.6,1789.7,1866.2,1.1472930080710984,0.19823388944175477,0.020077325085410658,1.6972941489985984,0.11620737899695065,0.9347662940118673,1349]
["High","P09001","39S ribosomal protein L3, mitochondrial [OS=Homo sapiens]",30,7,22,7,348,38.6,9.48,40.19,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL3","ENSG00000114686","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",865.5,865.7,871.4,930.7,902.5,949.9,0.9351442635909598,-0.09673914987363844,0.01236515707642768,1.9078003623603073,0.09091068404213495,1.041385074447122,1062]
["Medium","P09382","Galectin-1 [OS=Homo sapiens]",6,1,1,1,135,14.7,5.5,2.09,"stress response;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LGALS1","ENSG00000100097","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",61.1,53.4,54.3,63.4,52.3,39.8,1.0855305466237943,0.11840032368922042,0.5732650857964305,0.24164450774161084,0.7604576605332194,0.11892496084656762,5886]
["High","P09496-2","Isoform Non-brain of Clathrin light chain A [OS=Homo sapiens]",24,5,11,5,218,23.6,4.53,24.57,"","","","CLTA","","","","",504.8,425,434.9,770.5,422.4,359.8,0.8789205899401041,-0.18619527044573284,0.6554321664016605,0.18347224872119633,0.8141289142959219,0.08930682074412209,6286]
["High","P09525","annexin A4 [OS=Homo sapiens]",44,13,29,12,319,35.9,6.13,41.2,"signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","enzyme regulator activity;other molecular function","ANXA4","ENSG00000196975","Prostaglandin synthesis and regulation","","",600.3,556.8,580.7,616.9,647.6,634,0.9153542270213325,-0.12759794419895593,0.025376757045283048,1.5955638781958446,0.1290825531006971,0.8891324533504144,1535]
["High","P09884","DNA polymerase alpha catalytic subunit [OS=Homo sapiens]",26,30,71,30,1462,165.8,5.85,155.47,"cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLA1","ENSG00000101868","Retinoblastoma gene in cancer; Pyrimidine metabolism; Nucleotide metabolism; DNA replication","Defective pyroptosis; Activation of the pre-replicative complex; G1/S-Specific Transcription; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate","DNA replication",3128.7,3375.3,3257.7,3465,3334.6,3398.4,0.9572171013924299,-0.06308192296534146,0.1453089955974174,0.8377074991404457,0.35071797144501854,0.4550419794865296,3235]
["Medium","P09958","Furin [OS=Homo sapiens]",1,1,1,1,794,86.6,6.47,2.67,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","FURIN","ENSG00000140564","SARS-CoV-2 altering angiogenesis via NRP1","Potential therapeutics for SARS; Formation of the cornified envelope; Amyloid fiber formation; Collagen degradation; Signaling by PDGF; Signaling by NODAL; Pre-NOTCH Processing in Golgi; Uptake and function of anthrax toxins; Attachment and Entry; Assembly of active LPL and LIPC lipase complexes; Activation of Matrix Metalloproteinases; TGF-beta receptor signaling activates SMADs; Removal of aminoterminal propeptides from gamma-carboxylated proteins; NGF processing; Synthesis and processing of ENV and VPU; Elastic fibre formation; CD163 mediating an anti-inflammatory response","",61.1,61.9,49.3,81.9,73.3,73.4,0.7537182852143482,-0.40790270198953,0.01952068787080424,1.7095048827128208,0.11599507678480937,0.9355604432779473,1314]
["High","P0CG38","POTE ankyrin domain family member I [OS=Homo sapiens]",11,10,241,1,1075,121.2,6.21,501.86,"","","","POTEI","ENSG00000196834","","","",1028.1,993,961.8,780.5,753.4,819.7,1.2673776342624061,0.34184646126028945,1.5109662836450765E-3,2.8207452265876887,0.03214611646512468,1.4928714861811427,367]
["High","P10070-1","Isoform 1 of Zinc finger protein GLI2 [OS=Homo sapiens]",5,4,5,2,1258,133.2,7.14,12.6,"","","","GLI2","","","","",81.8,83.2,87.1,116.4,109.3,122.1,0.7248418631397355,-0.46426181444804726,1.3753332584884616E-3,2.8615920547165934,0.03139942129321026,1.503078356114093,342]
["High","P10109","Adrenodoxin, mitochondrial [OS=Homo sapiens]",16,2,10,2,184,19.4,5.83,18.72,"other metabolic processes;other biological processes","mitochondrion","other molecular function","FDX1","ENSG00000137714","","Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin","",157.3,158.4,149.7,155.6,118,132.1,1.147153068770027,0.1980579081990757,0.15309955225844063,0.8150260793995371,0.36049496502831857,0.44310079661913765,3316]
["High","P10398-1","serine/threonine-protein kinase A-Raf [OS=Homo sapiens]",21,10,14,7,606,67.5,9.01,21.9,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","ARAF","ENSG00000078061; ENSGGOG00000008695; ENSPPAG00000015632; ENSPTRG00000021846","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Common pathways underlying drug addiction; Bladder cancer; MAPK signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Alzheimer's disease; ErbB signaling pathway","Signaling by BRAF and RAF1 fusions; RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; FoxO signaling pathway; Vascular smooth muscle contraction; Natural killer cell mediated cytotoxicity; Long-term potentiation; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Parathyroid hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Pathways in cancer; Proteoglycans in cancer; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer",836.8,979.8,917.2,874,986.1,919.6,0.9834874267007233,-0.02402148625998239,0.7858099060005012,0.10468250072879556,0.8903792985128302,0.05042494598484871,6891]
["High","P10620","Microsomal glutathione S-transferase 1 [OS=Homo sapiens]",23,3,16,3,155,17.6,9.39,26.69,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGST1","ENSG00000008394","Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Oxidative stress response; Metapathway biotransformation Phase I and II","Neutrophil degranulation; Aflatoxin activation and detoxification; Glutathione conjugation","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",841.2,993.4,972.6,719,951.3,847.2,1.1150744786494537,0.15714007462065718,0.306064154062551,0.5141875315736347,0.5394467076569747,0.26805145313806894,4430]
["High","P10809","60 kDa heat shock protein, mitochondrial [OS=Homo sapiens]",83,51,1952,51,573,61,5.87,4312.07,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","HSPD1","ENSG00000144381","Apoptosis-related network due to altered Notch3 in ovarian cancer; Sudden infant death syndrome (SIDS) susceptibility pathways","Mitochondrial protein import; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation","RNA degradation; Type I diabetes mellitus; Legionellosis; Tuberculosis; Lipid and atherosclerosis",44547.8,43622.7,43045.1,43167.6,42084,43298.2,1.0207374885063998,0.02961188411423251,0.2019949717877347,0.6946594412069401,0.4226089870628705,0.37406127162276703,3732]
["High","P11137","microtubule-associated protein 2 [OS=Homo sapiens]",8,10,19,3,1827,199.4,4.91,47.97,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAP2","ENSG00000078018","Melatonin metabolism and effects; MAPK cascade; Sudden infant death syndrome (SIDS) susceptibility pathways","","",640.7,698.2,625.8,589.8,485,510.4,1.2394019682059045,0.3096441644651195,0.030376118032780466,1.5174677283226428,0.1435694489103813,0.8429379666483707,1652]
["High","P11177","Pyruvate dehydrogenase E1 component subunit beta, mitochondrial [OS=Homo sapiens]",48,13,113,13,359,39.2,6.65,231.16,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","PDHB","ENSG00000168291","Metabolic reprogramming in colon cancer; Orexin receptor pathway","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Glycolysis / Gluconeogenesis; Citrate cycle (TCA cycle); Pyruvate metabolism; Metabolic pathways; Carbon metabolism; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer; Diabetic cardiomyopathy",5070.4,5137.4,5310.9,4988.3,5217.8,5191.9,1.007838680348097,0.011264732402146734,0.7133464195838832,0.146699514219622,0.8512622411907321,0.0699366298593493,6543]
["High","P11233","Ras-related protein Ral-A [OS=Homo sapiens]",42,9,54,5,206,23.6,7.11,136.81,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","RALA","ENSG00000006451","RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; p38MAPK events","Ras signaling pathway; Rap1 signaling pathway; Phospholipase D signaling pathway; Salmonella infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer",2047.6,2065.1,2017.4,1882.5,1974.8,1892.3,1.0661785167663838,0.09244901754473257,0.0173557979851554,1.7605554135349244,0.10849805497845748,0.9645780472504244,1249]
["High","P11441","Ubiquitin-like protein 4A [OS=Homo sapiens]",29,4,8,4,157,17.8,8.66,12.29,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;cytosol;nucleus;other cell component","other molecular function","UBL4A","ENSG00000102178","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",195.3,179.4,158.4,217.1,168.5,170.4,0.9588129496402878,-0.060678700861035315,0.7105623947347823,0.14839778051025931,0.8502791077531311,0.0704384918619425,6525]
["High","P11717","Cation-independent mannose-6-phosphate receptor [OS=Homo sapiens]",25,50,104,50,2491,274.2,5.94,235.02,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","IGF2R","ENSG00000197081","","Retrograde transport at the Trans-Golgi-Network; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis","Lysosome; Endocytosis",3947.4,4142.9,3923.2,4083,4154.2,4149.4,0.9698787399286325,-0.044123710720865884,0.16476383078422474,0.7831381191852151,0.37484731665595183,0.4261455937032476,3432]
["High","P12036","Neurofilament heavy polypeptide [OS=Homo sapiens]",4,4,11,2,1026,112.4,6.18,23.38,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","NEFH","ENSG00000100285","Amyotrophic lateral sclerosis (ALS); Physico-chemical features and toxicity-associated pathways","","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",33.6,36,41.5,22.3,36.1,28.3,1.281430219146482,0.3577549181672568,0.15374830783373836,0.8131896554062956,0.3615863817969365,0.4417879344516965,3320]
["High","P12259","Coagulation factor V [OS=Homo sapiens]",0,1,2,1,2224,251.5,6.05,4.92,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","F5","ENSG00000198734","Blood clotting cascade; Complement and coagulation cascades","COPII-mediated vesicle transport; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Platelet degranulation ; Cargo concentration in the ER; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",100.9,92.4,127.8,76.1,78.2,97.1,1.2772474144789183,0.35303801530526235,0.13865201920654632,0.85807380135568,0.3407601403729033,0.46755121152419205,3177]
["High","P12277","Creatine kinase B-type [OS=Homo sapiens]",77,19,172,18,381,42.6,5.59,440.14,"other metabolic processes;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","kinase activity;other molecular function","CKB","ENSG00000166165","","RND3 GTPase cycle; Creatine metabolism","Arginine and proline metabolism; Metabolic pathways",4351.5,4824.8,4247.4,4093.3,3876.7,3861.7,1.1345537834799733,0.1821250015361734,0.05123886652421432,1.2904004860257865,0.19114814611613254,0.7186299097058376,2093]
["High","P12955","xaa-Pro dipeptidase [OS=Homo sapiens]",33,15,47,15,493,54.5,6,105.32,"protein metabolism;other metabolic processes","","other molecular function","PEPD","ENSG00000124299","","","",1578.5,1637.5,1610.8,1510.9,1519.6,1505.4,1.064132807160652,0.08967821500772132,0.005242252375476997,2.2804820748356898,0.05732703998280727,1.2416404819532287,714]
["Medium","P13056-1","Nuclear receptor subfamily 2 group C member 1 [OS=Homo sapiens]",1,1,1,1,603,67.3,6.32,1.83,"signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NR2C1","ENSG00000120798","","Nuclear Receptor transcription pathway; SUMOylation of intracellular receptors","",23.5,23.6,19.4,36,28.8,27.8,0.7181425485961124,-0.47765785287168433,0.04117815846849953,1.385333079399674,0.17102077729895973,0.7669511240047187,1880]
["High","P13533","myosin-6 [OS=Homo sapiens]",3,5,14,3,1939,223.6,5.73,30.89,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYH6","ENSG00000197616","Cardiac progenitor differentiation; Striated muscle contraction pathway; Acute viral myocarditis; IL-18 signaling pathway","Striated Muscle Contraction","cGMP-PKG signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Thyroid hormone signaling pathway; Hypertrophic cardiomyopathy; Dilated cardiomyopathy; Viral myocarditis",116.3,115.7,90,119.6,91.3,109,1.0065645514223196,0.009439695886305697,0.9561717734709654,0.019464080977753696,0.977709429971359,0.009790196040747485,7636]
["Medium","P13682","Zinc finger protein 35 [OS=Homo sapiens]",2,1,1,1,527,59.1,8.09,0,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF35","ENSG00000169981; ENSG00000281306","","","",38,43.2,39.8,29.8,42.9,42.2,1.0530896431679722,0.07462824951584361,0.676099006258403,0.1699897023966867,0.8266490825032276,0.08267881194147737,6386]
["Medium","P13726-1","tissue factor [OS=Homo sapiens]",5,2,4,1,295,33,7.03,7.18,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","F3","ENSG00000117525","Blood clotting cascade; VEGFA-VEGFR2 signaling pathway; Macrophage markers; STING pathway in Kawasaki-like disease and COVID-19; Complement and coagulation cascades","NGF-stimulated transcription; Extrinsic Pathway of Fibrin Clot Formation","Complement and coagulation cascades; AGE-RAGE signaling pathway in diabetic complications",152.9,160.4,169.8,159.9,165.1,169.8,0.9763540824575586,-0.03452364754429282,0.5289238750923732,0.27660682892193067,0.7286234327313427,0.13749686583871798,5668]
["High","P13984","General transcription factor IIF subunit 2 [OS=Homo sapiens]",58,13,28,13,249,28.4,9.23,46.49,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","GTF2F2","ENSG00000188342","Eukaryotic transcription initiation","Estrogen-dependent gene expression; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","Basal transcription factors",1414.5,1421.9,1269.6,1467.3,1285.8,1438.4,0.9796015746152928,-0.029733001990117504,0.7233384726960307,0.14065843517215038,0.8579411810436894,0.0665424856055938,6583]
["Medium","P14415","sodium/potassium-transporting ATPase subunit beta-2 [OS=Homo sapiens]",3,1,1,1,290,33.3,8.31,2.01,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ATP1B2","ENSG00000129244","Calcium regulation in cardiac cells","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS; Basigin interactions","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption",23.1,53.8,41.1,30.3,32.2,32.2,1.246040126715945,0.31735052878081865,0.43346696144072533,0.3630439985586688,0.6546441073363991,0.18399473699397592,5170]
["High","P14550","alcohol dehydrogenase [NADP(+)] [OS=Homo sapiens]",66,20,102,19,325,36.6,6.79,241.94,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","AKR1A1","ENSG00000117448","Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II","Glutathione conjugation; Formation of xylulose-5-phosphate","Glycolysis / Gluconeogenesis; Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Glycerolipid metabolism; Pyruvate metabolism; Metabolic pathways; Biosynthesis of cofactors; Chemical carcinogenesis",4435.9,4341.5,4395.8,4178,4172.4,4018.9,1.064991551664201,0.09084198592481811,0.01040080401223723,1.982933087183775,0.0826980424924117,1.0825047703120891,982]
["High","P14859-1","POU domain, class 2, transcription factor 1 [OS=Homo sapiens]",15,8,23,8,743,76.4,6.81,50.59,"other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","POU2F1","ENSG00000143190","Integrated cancer pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling","Herpes simplex virus 1 infection; Lipid and atherosclerosis",586.9,588,598.9,647.5,615.5,644.7,0.9298107668920692,-0.104990963016441,0.015032469276244164,1.8229696751040338,0.10049102749050894,0.9978727132217791,1168]
["High","P14868","Aspartate--tRNA ligase, cytoplasmic [OS=Homo sapiens]",65,29,143,29,501,57.1,6.55,308.42,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","DARS1","ENSG00000115866","Alanine and aspartate metabolism","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",6758.6,6703.6,6911.6,6693.7,7382.6,7153.3,0.9596883596487924,-0.05936210049224594,0.24942507299442251,0.6030598920130388,0.47932832142270515,0.31936690968081505,4063]
["High","P15260","Interferon gamma receptor 1 [OS=Homo sapiens]",4,2,3,2,489,54.4,4.91,3.74,"stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","IFNGR1","ENSG00000027697","Immune response to tuberculosis; Selective expression of chemokine receptors during T-cell polarization; Overview of interferons-mediated signaling pathway; Neuroinflammation and glutamatergic signaling; Type II interferon signaling (IFNG)","Potential therapeutics for SARS; Regulation of IFNG signaling","Cytokine-cytokine receptor interaction; HIF-1 signaling pathway; Necroptosis; Osteoclast differentiation; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Th1 and Th2 cell differentiation; Th17 cell differentiation; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Inflammatory bowel disease",92,87.9,79.1,87.7,66,80.8,1.1044776119402984,0.14336417517117717,0.3343794298754689,0.47576044704149156,0.5665873672889891,0.24673311279801174,4608]
["High","P15559-1","NAD(P)H dehydrogenase [quinone] 1 [OS=Homo sapiens]",31,7,15,7,274,30.8,8.88,40.65,"cell-cell signaling;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","NQO1","ENSG00000181019; ENSGGOG00000003294; ENSPTRG00000008284","Dopamine metabolism; Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Interactions between LOXL4 and oxidative stress pathway; Benzene metabolism; Oxidative stress response; NRF2-ARE regulation; Male infertility; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Estrogen metabolism","Regulation of ornithine decarboxylase (ODC)","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Pathways in cancer; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",877.3,880.3,966.5,857.9,982.1,871.1,1.0047951016192689,0.006901336214376408,0.9338567540140105,0.029719735881631286,0.9667930967039768,0.01466645929259729,7542]
["High","P16050","arachidonate 15-lipoxygenase [OS=Homo sapiens]",3,2,2,2,662,74.8,6.58,4.95,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","ALOX15","ENSG00000161905","Eicosanoid synthesis; Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence","Interleukin-4 and Interleukin-13 signaling; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of E-series 18(R)-resolvins; Biosynthesis of DPAn-3-derived protectins and resolvins; Biosynthesis of DPAn-6 SPMs","Arachidonic acid metabolism; Linoleic acid metabolism; Metabolic pathways; Ferroptosis; Necroptosis; Serotonergic synapse",139.3,140.1,129.6,133.3,129.9,110.6,1.0941680042803636,0.1298342740839529,0.20849348751665622,0.680907506060737,0.43157930819990764,0.36493938546739246,3772]
["High","P16083","Ribosyldihydronicotinamide dehydrogenase [quinone] [OS=Homo sapiens]",55,9,27,9,231,25.9,6.29,54.3,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","NQO2","ENSG00000124588","Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling","Phase I - Functionalization of compounds","",1028.5,1113.7,1091.5,1133.6,1107.4,1125.1,0.9606666468613528,-0.057892194951412075,0.17317282001464193,0.7615202707710759,0.3854428103404573,0.41404005080644335,3508]
["High","P16383-1","GC-rich sequence DNA-binding factor 2 [OS=Homo sapiens]",19,11,17,11,781,89.3,5.99,39.09,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity","GCFC2","ENSG00000005436","","mRNA Splicing - Major Pathway","",562.8,551.3,555.8,706.2,596.4,648.3,0.8559639140909324,-0.2243781184238384,0.04250181207576515,1.371592553297243,0.17383664153356432,0.7598586770322745,1909]
["High","P16435","NADPH--cytochrome P450 reductase [OS=Homo sapiens]",55,33,95,33,677,76.6,5.58,193.45,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","POR","ENSG00000127948","Oxidation by cytochrome P450; Ferroptosis","Cytochrome P450 - arranged by substrate type","",4450.3,4371.3,4633.9,3688.7,4023.7,3925.7,1.1561595105730318,0.2093404542721943,0.008658353490164947,2.062564687442453,0.07429057588044825,1.129066275104911,910]
["High","P16989-1","Y-box-binding protein 3 [OS=Homo sapiens]",66,17,93,12,372,40.1,9.77,253.02,"stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CSDA; YBX3","ENSG00000060138","RalA downstream regulated genes; Apoptosis-related network due to altered Notch3 in ovarian cancer","","Tight junction",2064,2036,1979.7,2427.9,2222.2,2254.6,0.8805161701449735,-0.18357859636891982,0.015934023864244654,1.7976745367310134,0.10367738194335188,0.9843159781200029,1200]
["High","P17081","Rho-related GTP-binding protein RhoQ [OS=Homo sapiens]",9,2,16,1,205,22.6,6.32,40.42,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","other molecular function","RHOQ","ENSG00000119729","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling","RHOQ GTPase cycle; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases regulate CFTR trafficking","Insulin signaling pathway",39.5,36.1,32.5,44.2,28.6,40.6,0.9532627865961197,-0.06905411720757888,0.7479388847595201,0.12613388755808602,0.8721485681305754,0.05940952788465421,6696]
["High","P17096-2","Isoform HMG-Y of High mobility group protein HMG-I/HMG-Y [OS=Homo sapiens]",49,5,11,1,96,10.7,10.32,23.63,"","","","HMGA1","","","","",566.5,595.5,664.6,646.9,577,463.2,1.0826862663742516,0.11461524893092842,0.48788022648232326,0.31168678324792315,0.6973034611704155,0.1565781791038702,5463]
["High","P17600-2","Isoform IB of Synapsin-1 [OS=Homo sapiens]",24,11,19,11,669,70,9.88,29.56,"","","","SYN1","","","","",426.6,421,420.3,369.8,372.7,368.1,1.1416351521699983,0.19110166273689397,2.6132606298927476E-5,4.582817274360075,0.006376355936938304,2.1954274480213454,32]
["High","P17844","probable ATP-dependent RNA helicase DDX5 [OS=Homo sapiens]",56,38,292,29,614,69.1,8.92,601.5,"RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX5","ENSG00000108654","Ciliary landscape","Estrogen-dependent gene expression; mRNA Splicing - Major Pathway; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome; SUMOylation of transcription cofactors","Spliceosome; Transcriptional misregulation in cancer; Proteoglycans in cancer",12790.7,12747.1,13348.6,13380.2,14092.3,14029.1,0.9369855620024288,-0.09390127729956753,0.04335557203355682,1.3629550793200031,0.17576339898131446,0.7550715574498834,1926]
["High","P17858-1","ATP-dependent 6-phosphofructokinase, liver type [OS=Homo sapiens]",44,26,65,22,780,85,7.5,161.78,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;other cell component","kinase activity;other molecular function","PFKL","ENSG00000141959; ENSPTRG00000022972","Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Insulin signaling; Glycolysis and gluconeogenesis","Neutrophil degranulation; Glycolysis","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Galactose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway; AMPK signaling pathway; Thyroid hormone signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer",3041.5,3128.8,3339.7,2956.6,3303.1,3017.5,1.0250937782951752,0.03575589733335599,0.6057204523273323,0.2177277620095668,0.7813423578013895,0.10715863126348343,6053]
["High","P18085","ADP-ribosylation factor 4 [OS=Homo sapiens]",79,10,76,6,180,20.5,7.14,177.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARF4","ENSG00000168374","VEGFA-VEGFR2 signaling pathway","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; VxPx cargo-targeting to cilium","Endocytosis",1975.1,1712.5,2099.9,1607.9,1892.5,1693.3,1.1143308238827812,0.15617760531766878,0.23559851048890698,0.6278274595916139,0.4648858149854399,0.3326537051990062,3957]
["High","P18583-5","Isoform D of Protein SON [OS=Homo sapiens]",23,38,165,8,2459,266.9,5.73,368.2,"","","","SON","","","","",5301,5273.7,5368.7,5832.7,5505.7,5583.1,0.9421977957036907,-0.0858981381002441,0.03363343266804414,1.4732288058131864,0.15259142491114971,0.8164698714821111,1721]
["High","P18669","Phosphoglycerate mutase 1 [OS=Homo sapiens]",81,19,241,19,254,28.8,7.18,546.26,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","PGAM1","ENSG00000171314","Cori cycle; Metabolic reprogramming in colon cancer; Glycolysis and gluconeogenesis","Neutrophil degranulation; Glycolysis; Gluconeogenesis","Glycolysis / Gluconeogenesis; Glycine, serine and threonine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Glucagon signaling pathway; Central carbon metabolism in cancer",9408.2,10171.7,8925.6,9879.3,9036.1,9443.6,1.00516590852992,0.007433646338295826,0.9163834767091277,0.03792275016655897,0.9565671371851429,0.019284543372384954,7480]
["High","P19012","Keratin, type I cytoskeletal 15 [OS=Homo sapiens]",12,8,31,1,456,49.2,4.77,73.53,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","KRT15","ENSG00000171346","","Formation of the cornified envelope","Estrogen signaling pathway; Staphylococcus aureus infection",28.5,31.5,26.7,32.5,37.6,33,0.8409311348205626,-0.24994043414627334,0.0632794387340271,1.1987373815299107,0.2148199381022972,0.6679254128888683,2300]
["High","P19086","guanine nucleotide-binding protein G(z) subunit alpha [OS=Homo sapiens]",4,1,1,1,355,40.9,7.61,3.2,"signal transduction","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus","signal transduction activity or receptor binding;other molecular function","GNAZ","ENSG00000128266","Corticotropin-releasing hormone signaling pathway; G protein signaling pathways; Purinergic signaling; Calcium regulation in cardiac cells","G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; ADORA2B mediated anti-inflammatory cytokines production","Long-term depression",24,24.4,17,20.7,29.7,29.8,{"$f":"AVERAGE(T1474:V1474)/AVERAGE(W1474:Y1474)","v":0.8154613466334164},{"$f":"LOG(Z1474,2)","v":-0.29431160095683784},{"$f":"TTEST(T1474:V1474,W1474:Y1474,2,2)","v":0.27000993601110024},{"$f":"-LOG10(AB1474)","v":0.5686202540802868},{"$f":"AB1474*7808/AF1474","v":0.500887997237983},{"$f":"-LOG10(AD1474)","v":0.3002593751696738},4209]
["High","P19367-1","Hexokinase-1 [OS=Homo sapiens]",46,39,161,36,917,102.4,6.8,376.43,"other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion","kinase activity;other molecular function","HK1","ENSG00000156515","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Glycolysis and gluconeogenesis; Glucuronidation","Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)","Glycolysis / Gluconeogenesis; Fructose and mannose metabolism; Galactose metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Neomycin, kanamycin and gentamicin biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of nucleotide sugars; HIF-1 signaling pathway; Insulin signaling pathway; Type II diabetes mellitus; Carbohydrate digestion and absorption; Shigellosis; Central carbon metabolism in cancer",8024.4,7847.9,8436.8,7989.1,8780.4,8633.2,0.9569494581284665,-0.06348536498583124,0.28994756633236796,0.5376805321403183,0.5224810980667272,0.2819294165160578,4333]
["High","P19793","retinoic acid receptor RXR-alpha [OS=Homo sapiens]",11,4,5,4,462,50.8,7.8,7.86,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RXRA","ENSG00000186350","Vitamin D metabolism; Energy metabolism; Nuclear receptors; Adipogenesis; Liver X receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Vitamin D receptor pathway; PPAR-alpha pathway; Farnesoid X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Prion disease pathway; PI3K/AKT/mTOR - VitD3 signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Vitamins A and D - action mechanisms; Nonalcoholic fatty liver disease; Vitamin D in inflammatory diseases; Small cell lung cancer; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Vitamin A and carotenoid metabolism","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Regulation of pyruvate dehydrogenase (PDH) complex; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; SUMOylation of intracellular receptors; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Endogenous sterols; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Signaling by Retinoic Acid; Nuclear Receptor transcription pathway; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Recycling of bile acids and salts; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; Transcriptional regulation of granulopoiesis; RORA activates gene expression; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis","PPAR signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation; Thyroid hormone signaling pathway; Adipocytokine signaling pathway; Parathyroid hormone synthesis, secretion and action; Non-alcoholic fatty liver disease; Bile secretion; Hepatitis C; Pathways in cancer; Transcriptional misregulation in cancer; Chemical carcinogenesis; Thyroid cancer; Small cell lung cancer; Non-small cell lung cancer; Gastric cancer; Lipid and atherosclerosis",151.7,125.7,150,166.2,179,182.2,0.8103905953735306,-0.30331066320474903,0.026523077592019453,1.576376084200755,0.13258142755344934,0.8775173090834011,1562]
["High","P20073-1","Annexin A7 [OS=Homo sapiens]",36,16,55,16,488,52.7,5.68,88.88,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ANXA7","ENSG00000138279","","","Amyotrophic lateral sclerosis",1864.5,1773.2,1896.8,1712.9,1877,1756.7,1.0351438297235627,0.04983123923413608,0.36573007201603397,0.4368393284952145,0.5977853050661908,0.22345476511993292,4777]
["High","P20337","Ras-related protein Rab-3B [OS=Homo sapiens]",48,8,31,6,219,24.7,5.02,55.97,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3B","ENSG00000169213","Intracellular trafficking proteins involved in CMT neuropathy","RAB geranylgeranylation","",799.7,833.9,888.2,818.4,927.2,886.7,0.9580215021084223,-0.061870058302665704,0.4186111509481701,0.378189207123093,0.64290241278586,0.1918549443464281,5084]
["High","P20340-2","Isoform 2 of Ras-related protein Rab-6A [OS=Homo sapiens]",53,14,46,10,208,23.5,5.54,85.21,"","","","RAB6A","","","","",3967.7,3769.7,4016.7,3454.7,4103,3765.6,1.0380454461155317,0.053869606942666286,0.5161193235918591,0.28724988056924283,0.7187194005003096,0.1434406320091019,5607]
["High","P20936-1","ras GTPase-activating protein 1 [OS=Homo sapiens]",10,8,17,8,1047,116.3,6.54,37.16,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RASA1","ENSG00000145715","PDGF pathway; T cell receptor and co-stimulatory signaling; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; EPO receptor signaling","Regulation of RAS by GAPs; VEGFR2 mediated cell proliferation; EPHB-mediated forward signaling; Downstream signal transduction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases","MAPK signaling pathway; Ras signaling pathway; Axon guidance",550,542.4,574.9,553.1,540.2,550.5,1.0142961430831001,0.02047893614823111,0.5000091503720772,0.3010220478245057,0.7055975865001226,0.15144291338002278,5533]
["High","P21283","V-type proton ATPase subunit C 1 [OS=Homo sapiens]",37,14,26,14,382,43.9,7.46,50.96,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity","ATP6V1C1","ENSG00000155097","Proximal tubule transport","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",1725.8,1746,1728.1,1677,1686.1,1693.7,1.0282985287138109,0.0402591588625409,0.003980319589674275,2.4000820559515073,0.0499651693829208,1.3013326359836905,622]
["High","P21709","Ephrin type-A receptor 1 [OS=Homo sapiens]",13,9,18,9,976,108.1,6.64,29.06,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","EPHA1","ENSG00000146904; ENSG00000284816","","EPHA-mediated growth cone collapse; EPH-ephrin mediated repulsion of cells; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","Axon guidance",1056.2,1077,1114.5,1169.3,1204.4,1237.1,0.8994405671873269,-0.15290013998859717,0.009580429223129218,2.0186150331906934,0.07874104355178203,1.1037988338209057,950]
["High","P21926","CD9 antigen [OS=Homo sapiens]",30,8,35,8,228,25.4,7.15,61.17,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","CD9","ENSG00000010278","Vitamin D receptor pathway","Platelet degranulation ; Uptake and function of diphtheria toxin; Acrosome Reaction and Sperm:Oocyte Membrane Binding","Hematopoietic cell lineage",1521.8,1632.2,1456.4,1847.8,1773.9,1827.6,0.8460536215660728,-0.24117899287081176,0.007448977456934972,2.1279033400422667,0.0684254305691156,1.1647824610979243,850]
["High","P22087","rRNA 2'-O-methyltransferase fibrillarin [OS=Homo sapiens]",53,19,122,16,321,33.8,10.18,265.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","FBL","ENSG00000105202; ENSG00000280548","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",5792.5,5933.2,5767.9,5179.4,5688.8,5685.7,1.0567660792924929,0.0796560639552285,0.15139671437005217,0.8198835498454541,0.35930259750801435,0.44453964313679306,3290]
["High","P22307-1","Non-specific lipid-transfer protein [OS=Homo sapiens]",30,13,48,13,547,59,6.89,87.75,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","SCP2","ENSG00000116171","PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; DNA damage response (only ATM dependent)","TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism","Primary bile acid biosynthesis; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome",1881.1,2012.9,1753.7,2093,1924.5,1869.9,0.9592859326697694,-0.05996719397139402,0.47125403194714544,0.3267449210409926,0.6840586505750719,0.1649066606642025,5379]
["High","P22626","heterogeneous nuclear ribonucleoproteins A2/B1 [OS=Homo sapiens]",91,30,462,27,353,37.4,8.95,1127.2,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPA2B1","ENSG00000122566","mRNA processing","mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Processing of Capped Intron-Containing Pre-mRNA","Amyotrophic lateral sclerosis",20506.7,24449.8,20820,22637.4,22507.7,23059.2,0.9644040038531295,-0.0522904543916933,0.560480349257787,0.2514396093999869,0.752317443184597,0.1235988685397193,5817]
["High","P23142","Fibulin-1 [OS=Homo sapiens]",15,8,12,8,703,77.2,5.22,29.01,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;extracellular matrix","signal transduction activity or receptor binding;enzyme regulator activity;extracellular structural activity;other molecular function","FBLN1","ENSG00000077942","","Molecules associated with elastic fibres","",224.7,236.1,247,237.6,250.1,258.9,0.9480310742030538,-0.0769937468778395,0.2208467342602419,0.6559090184261589,0.44695990178952016,0.3497314370753892,3858]
["High","P23368-1","NAD-dependent malic enzyme, mitochondrial [OS=Homo sapiens]",41,14,61,14,584,65.4,7.61,109.36,"other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","ME2","ENSG00000082212","TCA cycle in senescence","Citric acid cycle (TCA cycle)","Pyruvate metabolism; Carbon metabolism",1444.1,1523.7,1605.1,1553.6,1693.5,1631.1,0.9374154401213562,-0.09323953731913215,0.1739982234824026,0.7594551858307808,0.3865087137839543,0.41284071052798815,3515]
["High","P23458","Tyrosine-protein kinase JAK1 [OS=Homo sapiens]",4,4,6,4,1154,133.2,7.55,12.61,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK1","ENSG00000162434","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-17 signaling pathway; Type III interferon signaling; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Overview of interferons-mediated signaling pathway; Measles virus infection; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; TGF-beta receptor signaling in skeletal dysplasias; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; IL-2 signaling pathway; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; Malignant pleural mesothelioma; TGF-beta receptor signaling; Interferon type I signaling pathways; Type II interferon signaling (IFNG)","Potential therapeutics for SARS; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Interleukin-4 and Interleukin-13 signaling; Interleukin-6 signaling; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; IL-6-type cytokine receptor ligand interactions; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-27 signaling; ISG15 antiviral mechanism; Interleukin-10 signaling; Interleukin-7 signaling; Regulation of IFNA signaling; Interleukin-2 signaling; Other interleukin signaling; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling","EGFR tyrosine kinase inhibitor resistance; PI3K-Akt signaling pathway; Necroptosis; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; NOD-like receptor signaling pathway; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Pancreatic cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer",159.3,163.5,168.9,146.6,144.7,162,1.084712111184646,0.1173121939346299,0.10554012735213357,0.9765823861083408,0.2912892592313393,0.5356755289066962,2829]
["High","P23511","Nuclear transcription factor Y subunit alpha [OS=Homo sapiens]",5,1,7,1,347,36.9,8.94,6.86,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFYA","ENSG00000001167","Sterol regulatory element-binding proteins (SREBP) signaling; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways","ATF4 activates genes in response to endoplasmic reticulum  stress; PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF6 (ATF6-alpha) activates chaperone genes","Antigen processing and presentation; Spinocerebellar ataxia; Tuberculosis",98,104,93.8,98.9,93.4,93.2,1.0360770577933451,0.05113130684886275,0.382117729017798,0.4178028119949778,0.6110127438400506,0.2139497316204659,4883]
["High","P24385","G1/S-specific cyclin-D1 [OS=Homo sapiens]",16,3,3,2,295,33.7,5.02,9.57,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCND1","ENSG00000110092","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Leptin signaling pathway; IL-7 signaling pathway; Glioblastoma signaling pathways; Spinal cord injury; Retinoblastoma gene in cancer; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Mammary gland development pathway - Puberty (Stage 2 of 4); Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Bladder cancer; Mesodermal commitment pathway; Vitamin D receptor pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; Focal adhesion; Copper homeostasis; Photodynamic therapy-induced NF-kB survival signaling; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; Non-small cell lung cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Wnt signaling; Acute viral myocarditis; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; G1 to S cell cycle control; Hippo-Merlin signaling dysregulation; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Melanoma; FGF23 signaling in hypophosphatemic rickets and related disorders; EGFR tyrosine kinase inhibitor resistance; Influence of laminopathies on Wnt signaling; Development of ureteric collection system; Malignant pleural mesothelioma; Notch signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)","Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Cyclin D associated events in G1; Interleukin-4 and Interleukin-13 signaling; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Transcriptional Regulation by VENTX; RMTs methylate histone arginines; Transcriptional regulation by RUNX2; RUNX3 regulates WNT signaling; RUNX3 regulates p14-ARF; PTK6 Regulates Cell Cycle; Regulation of RUNX1 Expression and Activity","Endocrine resistance; FoxO signaling pathway; Cell cycle; p53 signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Cellular senescence; Wnt signaling pathway; Hedgehog signaling pathway; Apelin signaling pathway; Hippo signaling pathway; Focal adhesion; Tight junction; JAK-STAT signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Alcoholic liver disease; Hepatitis C; Measles; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Viral myocarditis",56.5,51.4,55.7,47.3,48.7,46.1,1.151301900070373,0.20326619369896853,0.014990434732186272,1.8241857721515944,0.10029589921928912,0.9987168235383291,1167]
["Low","P24864-1","G1/S-specific cyclin-E1 [OS=Homo sapiens]",2,1,1,1,410,47,6.04,0,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNE1","ENSG00000105173","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; ATM signaling pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Malignant pleural mesothelioma; ID signaling pathway; DNA damage response","CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; G1/S-Specific Transcription; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); RHOBTB3 ATPase cycle; DNA Damage/Telomere Stress Induced Senescence; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle","Cell cycle; Oocyte meiosis; p53 signaling pathway; PI3K-Akt signaling pathway; Cellular senescence; Cushing syndrome; Hepatitis B; Measles; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Prostate cancer; Small cell lung cancer; Gastric cancer",20.6,19.9,29.2,26.3,29.2,30.4,0.8114086146682188,-0.30149947527004056,0.16970589351153087,0.7703030753305673,0.38208293441119756,0.4178423594761046,3468]
["High","P25205","DNA replication licensing factor mcm3 [OS=Homo sapiens]",65,46,326,46,808,90.9,5.77,658.4,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3","ENSG00000112118","Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Unwinding of DNA","DNA replication; Cell cycle",11192.1,10789.1,11008.7,12050.6,12015.6,12105.2,0.9120437693868636,-0.13282503325814884,8.8700437295800383E-4,3.052074239078252,0.026740270826471405,1.5728341985008685,259]
["High","P25490","Transcriptional repressor protein YY1 [OS=Homo sapiens]",28,9,22,9,414,44.7,6.25,49.12,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","YY1","ENSG00000100811","Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Malignant pleural mesothelioma","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; UCH proteinases; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors","",1099.9,944.7,994.3,1069.5,991.2,1014.3,0.9882601626016261,-0.017037209062474825,0.8261331629617241,0.08294994386810983,0.9153466349375822,0.03841441070674273,7047]
["High","P25788-1","Proteasome subunit alpha type-3 [OS=Homo sapiens]",40,13,55,13,255,28.4,5.33,117.92,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMA3","ENSCANG00000039836; ENSCATG00000039369; ENSCJAG00000018732; ENSCSAG00000014435; ENSG00000100567; ENSGGOG00000015814; ENSMFAG00000002833; ENSMLEG00000041984; ENSMMUG00000003509; ENSMNEG00000035144; ENSNLEG00000013092; ENSPANG00000007163; ENSPPAG00000035468; ENSPPYG00000005855; ENSPTRG00000006390; ENSRROG00000040700; ENSSBOG00000021565","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",3885.8,3692.6,4182.5,3829.2,4265.8,4061.2,0.9674816143202644,-0.047693849838078305,0.5267168990882849,0.2784227475945685,0.7260956123024944,0.1390061876176457,5664]
["High","P26358-1","DNA (cytosine-5)-methyltransferase 1 [OS=Homo sapiens]",46,63,199,1,1616,183.1,7.75,415.46,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT1","ENSG00000130816","Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency","NoRC negatively regulates rRNA expression; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer",264.7,279,272,303.6,264.5,270.6,0.9725766066531538,-0.040116203980470784,0.582248164239435,0.23489187207098078,0.7670311568047087,0.11518699465136356,5927]
["High","P26572","alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [OS=Homo sapiens]",5,2,2,2,445,50.8,9.16,6.61,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MGAT1","ENSG00000131446","","Maturation of spike protein; Maturation of spike protein; N-glycan trimming and elongation in the cis-Golgi","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways",209.1,190,243.9,165.9,213.8,199.8,1.1095772217428819,0.15001007632147564,0.3753911876542496,0.42551592670149474,0.6057148983683367,0.21773174415148325,4839]
["High","P26641","elongation factor 1-gamma [OS=Homo sapiens]",72,29,252,29,437,50.1,6.67,477.94,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","EEF1G","ENSG00000254772","Translation factors","Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation","Legionellosis",10420.4,10043.4,10112.6,9422.1,9798.8,9524,1.0637156504284238,0.08911254506593304,0.01943130625856679,1.7114980032180853,0.11590499562023643,0.9358978451102058,1309]
["High","P27348","14-3-3 protein theta [OS=Homo sapiens]",69,21,560,15,245,27.7,4.78,1098.18,"transport;signal transduction;other biological processes","cytosol;other cell component","other molecular function","YWHAQ","ENSG00000134308","Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria","Cell cycle; Oocyte meiosis; PI3K-Akt signaling pathway; Hippo signaling pathway; Hepatitis C; Hepatitis B; Viral carcinogenesis",15100.9,14627.3,14826.2,14735.5,15148.2,13963.2,1.0161356903224628,0.023093066169409922,0.561999292577353,0.2502642311034395,0.7526741812082286,0.12339298120381813,5830]
["High","P27635","60S ribosomal protein L10 [OS=Homo sapiens]",46,11,154,11,214,24.6,10.08,304.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPL10","ENSG00000147403","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",4313.7,4298.6,4145.7,4232.8,3773.5,3761,1.0841909358986346,0.11661885080336763,0.11470849141964688,0.9404044317918712,0.30693759458690983,0.5129499146906685,2918]
["High","P27816-5","Isoform 5 of Microtubule-associated protein 4 [OS=Homo sapiens]",42,29,83,1,809,85.2,7.71,105.85,"","","","MAP4","","","","",134.2,121.5,131.8,115,140.4,126.1,1.0157273918741807,0.022513253327069216,0.8218492964509981,0.08520781228983658,0.9142326979184204,0.038943250043414375,7019]
["High","P28070","Proteasome subunit beta type-4 [OS=Homo sapiens]",48,8,60,8,264,29.2,5.97,122.95,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","other molecular function","PSMB4","ENSG00000159377","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of RUNX2 expression and activity; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint; UCH proteinases; Regulation of RUNX3 expression and activity; Regulation of ornithine decarboxylase (ODC); ROS sensing by NFE2L2; Regulation of PTEN stability and activity; Regulation of RAS by GAPs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",1181.8,1116,1219.4,1109.3,1254.4,1162.5,0.9974476773864218,-3.6869302992014645E-3,0.9568018605710897,0.019177988837508212,0.9774576641814822,0.009902043763846824,7643]
["Low","P28332-1","Alcohol dehydrogenase 6 [OS=Homo sapiens]",3,1,1,1,368,39.1,7.77,0,"","","","","","","","",93,87.5,98.7,76.6,95.3,93.8,1.0508091832894242,0.07150071371914565,0.545134800756919,0.2634960922444314,0.7411479234389733,0.13009510386696246,5743]
["High","P28799","Granulins [OS=Homo sapiens]",4,2,3,2,593,63.5,6.83,6.9,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GRN","ENSG00000030582","IL-18 signaling pathway","Neutrophil degranulation","",245.8,266.5,256.4,240.5,215.6,254.8,1.0813053875369247,0.11277403358475947,0.21012555364058336,0.6775211292681963,0.43392232817394205,0.36258800197209656,3781]
["High","P29084","transcription initiation factor iie subunit beta [OS=Homo sapiens]",41,10,40,9,291,33,9.66,62.58,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","GTF2E2","ENSG00000197265","Eukaryotic transcription initiation","RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors; Viral carcinogenesis",1202.6,1400.3,1148.5,1255.1,1085.8,1199.6,1.059567857647225,0.08347598483726101,0.4843488101101168,0.3148417628482784,0.6945446298144706,0.15829984228143673,5445]
["High","P29353","SHC-transforming protein 1 [OS=Homo sapiens]",31,12,25,12,583,62.8,6.44,61.33,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","signal transduction activity or receptor binding;other molecular function","SHC1","ENSG00000160691","IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; IL-4 signaling pathway; p38 MAPK signaling pathway; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; EGF/EGFR signaling pathway; Fragile X syndrome; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Malignant pleural mesothelioma; EPO receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)","Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Interleukin receptor SHC signaling; RET signaling; RAF/MAP kinase cascade; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; Signaling by CSF3 (G-CSF); XBP1(S) activates chaperone genes; SHC1 events in EGFR signaling; Integrin signaling; Erythropoietin activates RAS; Signalling to RAS; Signal attenuation; Interleukin-2 signaling; Interleukin-15 signaling","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; ErbB signaling pathway; Ras signaling pathway; Chemokine signaling pathway; Phospholipase D signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Insulin signaling pathway; Estrogen signaling pathway; Prolactin signaling pathway; Relaxin signaling pathway; Growth hormone synthesis, secretion and action; Alcoholism; Bacterial invasion of epithelial cells; MicroRNAs in cancer; Glioma; Chronic myeloid leukemia; Breast cancer; Hepatocellular carcinoma; Gastric cancer",1226.1,1095.7,1195,1116.7,1218.1,1155,1.0077368330563357,0.01111893326745799,0.8637387916470572,0.06361757522691135,0.9325321467339911,0.0303361880355828,7232]
["High","P29401","Transketolase [OS=Homo sapiens]",70,36,535,36,623,67.8,7.66,1322.77,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","TKT","ENSG00000163931","Pentose phosphate metabolism; VEGFA-VEGFR2 signaling pathway; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways","Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",24952.1,24606.3,24510.9,23548.3,25163.1,25030.1,1.0044452580975434,0.006398939856927026,0.8480272810740959,0.0715901762463964,0.9258105439914067,0.03347787737562223,7152]
["High","P30043","flavin reductase (NADPH) [OS=Homo sapiens]",35,5,13,5,206,22.1,7.65,29.56,"other metabolic processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","BLVRB","ENSG00000090013","Nuclear receptors meta-pathway; NRF2 pathway; IL-10 anti-inflammatory signaling pathway","Cytoprotection by HMOX1; Heme degradation","Riboflavin metabolism; Porphyrin metabolism; Metabolic pathways",335.9,339.3,317.6,376,310.5,337.2,0.9698153755983198,-0.04421796826839586,0.6365483280948796,0.19616861820332415,0.8011233632760831,0.09630060268625609,6204]
["High","P30047","GTP cyclohydrolase 1 feedback regulatory protein [OS=Homo sapiens]",19,1,1,1,84,9.7,6.54,2.46,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","GCHFR","ENSG00000137880","","Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","",15.1,10.8,15.3,15.5,8,15.2,1.0645994832041343,0.09031077103880804,0.7850572057031053,0.10509869584583421,0.8900430756686288,0.050588974172518925,6887]
["High","P30153","serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [OS=Homo sapiens]",60,32,294,24,589,65.3,5.11,599.14,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP2R1A","ENSG00000105568","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Cyclin A/B1/B2 associated events during G2/M transition; Regulation of TP53 Degradation; Regulation of PLK1 Activity at G2/M Transition; Cyclin D associated events in G1; Spry regulation of FGF signaling; Negative regulation of MAPK pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; TGF-beta signaling pathway; Hippo signaling pathway; Tight junction; Dopaminergic synapse; Long-term depression; Chagas disease; Hepatitis C; Human papillomavirus infection",10355.9,10262.7,10115.9,10158.3,9932.1,10020.4,1.0207134981468442,0.029577976101757216,0.09623000342734077,1.0166894987379933,0.27664354446269396,0.558079459687822,2716]
["High","P30291-1","Wee1-like protein kinase [OS=Homo sapiens]",10,6,9,6,646,71.6,6.77,14.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","WEE1","ENSG00000166483","Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control","Factors involved in megakaryocyte development and platelet production; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin A:Cdk2-associated events at S phase entry; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Polo-like kinase mediated events; G2/M DNA replication checkpoint; Cyclin E associated events during G1/S transition","Cell cycle; Human immunodeficiency virus 1 infection",267.7,269.2,259.2,241.2,256.2,272,1.0347023654795944,0.049215832846322013,0.3983294301221325,0.39975760504569385,0.6261639199503948,0.20331196038228175,4967]
["High","P30566","adenylosuccinate lyase [OS=Homo sapiens]",32,16,44,16,484,54.9,7.11,87.55,"other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","ADSL","ENSG00000239900","Nucleotide metabolism","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of cofactors",2808.5,2676.8,2652.3,2867.9,2791.9,2843.1,0.9570381869715039,-0.06335160376511155,0.08481898929515123,1.0715069069075975,0.2560969328756925,0.5915956227933373,2586]
["High","P30825","High affinity cationic amino acid transporter 1 [OS=Homo sapiens]",8,4,7,3,629,67.6,5.43,7.41,"transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC7A1","ENSG00000139514","VEGFA-VEGFR2 signaling pathway","Amino acid transport across the plasma membrane","MicroRNAs in cancer",375.4,358.7,354.5,425.9,405.8,422.5,0.8679636421623345,-0.20429348352023555,3.4461613027964117E-3,2.4626643986015986,0.0475399778308028,1.3229410251312348,566]
["High","P31040","Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [OS=Homo sapiens]",34,15,42,15,664,72.6,7.39,113.53,"other metabolic processes;developmental processes","other membranes;mitochondrion;nucleus","other molecular function","SDHA","ENSG00000073578","Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)","Respiratory electron transport; Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Oxidative phosphorylation; Metabolic pathways; Carbon metabolism; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",1685,1677.7,1713.2,1464.3,1460,1546.5,1.1353449047150397,0.18313063825002462,2.5977554029267846E-3,2.5854017432399155,0.04199435649286198,1.3768090693327921,483]
["High","P31350-1","ribonucleoside-diphosphate reductase subunit M2 [OS=Homo sapiens]",40,12,34,11,389,44.8,5.38,64.89,"cell organization and biogenesis;other metabolic processes;developmental processes","cytosol","other molecular function","RRM2","ENSG00000171848","Fluoropyrimidine activity; Retinoblastoma gene in cancer; Hepatitis C and hepatocellular carcinoma; Pyrimidine metabolism; Nucleotide metabolism; Orexin receptor pathway","G1/S-Specific Transcription; Transcriptional Regulation by E2F6; Interconversion of nucleotide di- and triphosphates","Purine metabolism; Pyrimidine metabolism; Glutathione metabolism; Drug metabolism; Metabolic pathways; p53 signaling pathway",814.5,852.2,890.7,835.3,916.2,845.7,0.9846758047127677,-0.022279285973274086,0.7131881855388554,0.14679585982896068,0.8513336420558604,0.06990020430229067,6541]
["High","P31689-1","DnaJ homolog subfamily A member 1 [OS=Homo sapiens]",65,20,120,20,397,44.8,7.08,309.2,"stress response;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","Dnaja1; DNAJA1; LOC109263810; LOC111146318; LOC112809310","ENSCAFG00000001474; ENSCAFG00000001818; ENSCATG00000033398; ENSCJAG00000008022; ENSCPOG00000000462; ENSECAG00000010324; ENSFCAG00000008729; ENSG00000086061; ENSGGOG00000007030; ENSLCNG00005016649; ENSMFAG00000032081; ENSMLEG00000042863; ENSMMUG00000007740; ENSMNEG00000030895; ENSNLEG00000005268; ENSOCUG00000004833; ENSPANG00000025299; ENSPPAG00000027533; ENSPPYG00000019141; ENSPTRG00000020852; ENSRROG00000029815; ENSSSCG00000011000; ENSSSCG00070018491; ENSSSUG00005020902; ENSSTOG00000005200","VEGFA-VEGFR2 signaling pathway; Exercise-induced circadian regulation","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","Protein processing in endoplasmic reticulum",4080.2,4260.1,4079.2,4434.8,4219.3,4385.9,0.952415644171779,-0.07033677669020272,0.0801335648714729,1.0961855365354944,0.24808995817464727,0.6053908141139217,2522]
["High","P31947-1","14-3-3 protein sigma [OS=Homo sapiens]",38,8,125,4,248,27.8,4.74,270.24,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","enzyme regulator activity;other molecular function","SFN","ENSG00000175793; ENSGGOG00000011493; ENSNLEG00000018582; ENSPPAG00000013397; ENSPTRG00000030723","miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; DNA damage response; Calcium regulation in cardiac cells","TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","Cell cycle; p53 signaling pathway; Aldosterone-regulated sodium reabsorption",270.6,297,301.8,310.7,313.3,327,0.9141955835962146,-0.1294252454698402,0.06772273496833876,1.1692655113180754,0.22330199097668457,0.6511074047103221,2368]
["High","P32322","Pyrroline-5-carboxylate reductase 1, mitochondrial [OS=Homo sapiens]",39,9,34,8,319,33.3,7.61,98.14,"other metabolic processes;stress response;other biological processes","mitochondrion","other molecular function","PYCR1","ENSG00000183010","Amino acid metabolism; Metabolic reprogramming in colon cancer","Glutamate and glutamine metabolism","Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids",1445.6,1460.3,1511.4,1488.3,1632.5,1603.7,0.9349772462694464,-0.09699683907817411,0.10163547799593067,0.9929546659859213,0.2857651466302581,0.5439907410775435,2777]
["High","P32519-1","ETS-related transcription factor Elf-1 [OS=Homo sapiens]",9,4,4,4,619,67.5,5.21,8.15,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ELF1","ENSG00000120690; ENSGGOG00000010760","","RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX1 regulates transcription of genes involved in BCR signaling","",104.3,111.6,121.3,86.8,91.6,97.1,1.223956442831216,0.2915522174835623,0.023273414666862585,1.6331398925112863,0.1231992011653309,0.9093921081668328,1475]
["High","P33897","ATP-binding cassette sub-family D member 1 [OS=Homo sapiens]",9,6,10,6,745,82.9,8.95,17.78,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ABCD1","ENSG00000101986","Vitamin D receptor pathway","Class I peroxisomal membrane protein import; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids; Linoleic acid (LA) metabolism; ABC transporters in lipid homeostasis; Defective ABCD1 causes ALD","ABC transporters; Peroxisome",482.3,454.9,457.8,445.7,452.7,420.7,1.0575392312940641,0.08071118367010889,0.12420029926349957,0.9058773577155584,0.3207925691860419,0.49377570023474016,3023]
["Low","P34741","syndecan-2 [OS=Homo sapiens]",5,1,1,1,201,22.1,4.86,0,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SDC2","ENSG00000169439","miRNA targets in ECM and membrane receptors","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cell surface interactions at the vascular wall; Syndecan interactions; EPHB-mediated forward signaling; A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Cell adhesion molecules; Malaria; Proteoglycans in cancer; Fluid shear stress and atherosclerosis",148.2,180.2,158.5,164.3,151.4,182.9,0.9765342960288806,-0.0342573822223734,0.7813131818095094,0.10717484849365076,0.8888960110110228,0.051149042725686746,6863]
["High","P34897-1","Serine hydroxymethyltransferase, mitochondrial [OS=Homo sapiens]",66,29,163,27,504,56,8.53,376.49,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","HEL-S-51e; SHMT2","ENSG00000182199","Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling","RHOG GTPase cycle; Metabolism of folate and pterines","Glycine, serine and threonine metabolism; Glyoxylate and dicarboxylate metabolism; One carbon pool by folate; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors; Antifolate resistance",6157.6,6295.6,6148.9,6007.4,6144,6190,1.0142137459517813,0.020361732940649878,0.2971540829045092,0.5270182981477652,0.5294794795340958,0.2761508667138163,4382]
["High","P35222","Catenin beta-1 [OS=Homo sapiens]",38,22,85,20,781,85.4,5.86,241.42,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CTNNB1","ENSG00000168036","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Heart development; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Gastric cancer network 2; Brain-derived neurotrophic factor (BDNF) signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Endoderm differentiation; Ectoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Focal adhesion; Ectoderm differentiation; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; OSX and miRNAs in tooth development; Wnt signaling pathway and pluripotency; PTF1A related regulatory pathway; Wnt signaling in kidney disease; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Genes controlling nephrogenesis; GDNF/RET signaling axis; Mammalian disorder of sexual development; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; 1q21.1 copy number variation syndrome; 7q11.23 copy number variation syndrome; Development of ureteric collection system; Malignant pleural mesothelioma; Alzheimer's disease; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response (only ATM dependent)","Deactivation of the beta-catenin transactivating complex; InlA-mediated entry of Listeria monocytogenes into host cells; RHO GTPases activate IQGAPs; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Myogenesis; Transcriptional Regulation by VENTX; Ca2+ pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; Apoptotic cleavage of cell adhesion  proteins; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production","Rap1 signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Leukocyte transendothelial migration; Melanogenesis; Thyroid hormone signaling pathway; Cushing syndrome; Alcoholic liver disease; Alzheimer disease; Pathways of neurodegeneration; Bacterial invasion of epithelial cells; Salmonella infection; Hepatitis C; Human cytomegalovirus infection; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Proteoglycans in cancer; Colorectal cancer; Endometrial cancer; Prostate cancer; Thyroid cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Arrhythmogenic right ventricular cardiomyopathy; Fluid shear stress and atherosclerosis",3558.4,3557.5,3617.4,3738.8,3778,3777.2,0.9503541703559412,-0.07346282923944288,1.3905274519348144E-3,2.85682043282922,0.03156173937414834,1.5008390707421146,344]
["High","P35249","replication factor C subunit 4 [OS=Homo sapiens]",61,19,43,19,363,39.7,8.02,86.27,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC4","ENSG00000163918","Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","Activation of ATR in response to replication stress; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",1912.9,1740.1,1689.9,2032.2,1909.8,1940.2,0.908316616232022,-0.1387328226493118,0.07961349140809265,1.0990133299055214,0.24736257099657277,0.6066660138394618,2513]
["High","P35250-1","Replication factor C subunit 2 [OS=Homo sapiens]",57,17,59,17,354,39.1,6.44,147.72,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC2","ENSG00000049541","DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Dual Incision in GG-NER; Termination of translesion DNA synthesis; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",1957.1,1904.2,2067.5,1995.2,2178.1,2034.7,0.9550257731958762,-0.06638842733044335,0.27413309244019024,0.5620385347024919,0.5045806661416797,0.2970693942243995,4242]
["High","P35555","Fibrillin-1 [OS=Homo sapiens]",3,8,10,5,2871,312,4.93,18.2,"","extracellular matrix","extracellular structural activity;other molecular function","","","","","",88.6,99.4,91.2,85.7,78.5,79.1,1.147554459515002,0.19856262127122298,0.039941509660926175,1.3985755242169655,0.1680297992632067,0.7746136914411732,1856]
["High","P35610","sterol O-acyltransferase 1 [OS=Homo sapiens]",13,6,13,6,550,64.7,8.94,16.73,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","other molecular function","SOAT1","ENSG00000057252","Statin inhibition of cholesterol production; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","LDL clearance","Steroid biosynthesis; Cholesterol metabolism",347.7,398.9,363.6,295.8,287.5,312.2,1.239754327191513,0.3100542608882589,0.013001978472898666,1.8859905573481506,0.09322263353204112,1.0304786324452901,1089]
["High","P35611-4","Isoform 4 of Alpha-adducin [OS=Homo sapiens]",43,22,80,2,662,73.3,6.16,141.49,"","","","ADD1","","","","",42.9,50,43.2,53,39.1,43,1.0074019245003702,0.01063939217831037,0.9473599006624716,0.023485001800985988,0.9740566373943347,0.011415789946128992,7594]
["High","P35813","Protein phosphatase 1A [OS=Homo sapiens]",36,12,35,11,382,42.4,5.36,68.31,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","PPM1A","ENSG00000100614","TGF-beta signaling pathway; MAPK signaling pathway","Downregulation of SMAD2/3:SMAD4 transcriptional activity; Energy dependent regulation of mTOR by LKB1-AMPK","MAPK signaling pathway",1391.7,1842.2,1330.5,1368,1452.5,1480.3,1.0612909226190474,0.08582018413996019,0.6222282495007007,0.20605027557420386,0.791521370495515,0.10153735501137225,6138]
["High","P36405","ADP-ribosylation factor-like protein 3 [OS=Homo sapiens]",59,9,46,9,182,20.4,7.24,88.28,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","ARL3","ENSG00000138175","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","Trafficking of myristoylated proteins to the cilium","",1339.9,1484.2,1314.8,1294.9,1306.8,1231.3,1.0798069397338899,0.1107733938830408,0.1522207038928353,0.8175262741429674,0.36005430354294393,0.4436319938146435,3301]
["High","P36543","V-type proton ATPase subunit E 1 [OS=Homo sapiens]",54,13,38,13,226,26.1,8,79.95,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V1E1","ENSG00000131100","VEGFA-VEGFR2 signaling pathway; Proximal tubule transport","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",1889.3,1942.1,1772.9,1878.1,1810.7,1831.6,1.0151981740453588,0.02176137943539693,0.6306497079322139,0.20021180106374928,0.7978147957768512,0.09809791379622457,6172]
["High","P36915-1","Guanine nucleotide-binding protein-like 1 [OS=Homo sapiens]",26,13,33,13,607,68.6,5.8,68.26,"stress response;signal transduction;other biological processes","non-structural extracellular","other molecular function","GNL1","ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986","","","",889.6,915.2,922,870.1,877.6,903.9,{"$f":"AVERAGE(T1858:V1858)/AVERAGE(W1858:Y1858)","v":1.0283602353296124},{"$f":"LOG(Z1858,2)","v":0.04034573017927074},{"$f":"TTEST(T1858:V1858,W1858:Y1858,2,2)","v":0.15280716343409123},{"$f":"-LOG10(AB1858)","v":0.8158562860288167},{"$f":"AB1858*7808/AF1858","v":0.36013230669887847},{"$f":"-LOG10(AD1858)","v":0.4435379172521412},3313]
["High","P36955","Pigment epithelium-derived factor [OS=Homo sapiens]",5,2,4,2,418,46.3,6.38,8.18,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other cell component","enzyme regulator activity","SERPINF1","ENSG00000132386","lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Type I collagen synthesis in the context of osteogenesis imperfecta; GPR143 in melanocytes and retinal pigment epithelium cells; Malignant pleural mesothelioma","","Wnt signaling pathway",69.6,77.2,97.4,72.6,92.8,85.1,0.9748502994011978,-0.036747403095167205,0.8465134326765167,0.07236614601221952,0.9255814146951746,0.03358537442835289,7141]
["High","P37837","Transaldolase [OS=Homo sapiens]",44,17,161,17,337,37.5,6.81,329.5,"other metabolic processes","cytosol;other cell component","other molecular function","TALDO1","ENSG00000177156","Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of  Fru(6)P, E4P to SH7P, GA3P","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",9237.1,9078.7,9241.6,9028.6,9062,8986.8,1.017726960491037,0.025350561825201134,0.050461259260507665,1.2970419158662865,0.18951491693412403,0.7223566005391201,2079]
["High","P38159-2","Isoform 2 of RNA-binding motif protein, X chromosome [OS=Homo sapiens]",67,34,266,11,378,40.8,10.04,391.98,"","","","RBMX","","","","",13842.8,14290.8,13823.7,16167.5,15243.1,16476.9,0.8761639258679197,-0.1907272788145383,0.00786284699052757,2.104420175537618,0.07040494186013677,1.1523968558115498,872]
["High","P39023","60S ribosomal protein L3 [OS=Homo sapiens]",47,22,295,22,403,46.1,10.18,487.69,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","other molecular function","RPL3","ENSG00000100316","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",12007.3,11885.3,12174,11173.9,12157.3,11959.9,1.0219743788093882,0.031359027950703604,0.45366781814205914,0.34326202721190224,0.6699902258470205,0.17393153295837835,5287]
["High","P40123","Adenylyl cyclase-associated protein 2 [OS=Homo sapiens]",32,14,33,13,477,52.8,6.37,71.97,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","cytoskeletal activity;other molecular function","CAP2","ENSG00000112186","Ectoderm differentiation; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway","Role of ABL in ROBO-SLIT signaling","",1331.3,1231.4,1267.2,1442.4,1503.2,1469.9,0.8673762880760956,-0.20527009086390968,0.004610462346470786,2.3362555204991557,0.0534895839543,1.2717307800644972,673]
["High","P40429","60S ribosomal protein L13a [OS=Homo sapiens]",42,12,97,12,203,23.6,10.93,170.49,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","RPL13A","ENSG00000142541","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",5378.5,5329.3,5531.9,4908,5689,5216,1.0269841269841269,0.038413883605228585,0.5779490050271016,0.2381104795939381,0.7636868897024216,0.11708466491496915,5909]
["High","P40937-1","Replication factor C subunit 5 [OS=Homo sapiens]",68,20,58,20,340,38.5,7.2,116.44,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC5","ENSG00000111445","Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","HDR through Homologous Recombination (HRR); Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Termination of translesion DNA synthesis; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",2642.3,2572.1,2956.9,2662.9,3022,2883.7,0.9536330322339707,-0.06849388570769728,0.44883543016964583,0.34791286806241284,0.6663827797612843,0.17627623421723482,5259]
["Medium","P41217","OX-2 membrane glycoprotein [OS=Homo sapiens]",4,1,1,1,278,31.2,8.51,2.55,"cell adhesion;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CD200","ENSG00000091972","Vitamin D receptor pathway","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","",153.6,123.8,132,151.9,170.2,138.5,0.8888406426400347,-0.170003308769435,0.25275082745985444,0.5973074139341501,0.48180626484534755,0.317127557243289,4096]
["High","P41225","Transcription factor SOX-3 [OS=Homo sapiens]",29,7,13,7,446,45.2,9.77,44.52,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SOX3","ENSG00000134595","","Deactivation of the beta-catenin transactivating complex","",355.2,318.4,367.3,228.8,249,232.7,1.4650246305418717,0.5509249199798799,0.002308784753571814,2.636616554173958,0.03979468290483162,1.4001749515281545,453]
["High","P41273","Tumor necrosis factor ligand superfamily member 9 [OS=Homo sapiens]",11,2,2,2,254,26.6,7.02,0,"cell-cell signaling;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding","TNFSF9","ENSG00000125657","Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling","TNFs bind their physiological receptors","Cytokine-cytokine receptor interaction",18.5,20.6,15.9,19.7,15.6,18.9,{"$f":"AVERAGE(T1922:V1922)/AVERAGE(W1922:Y1922)","v":1.014760147601476},{"$f":"LOG(Z1922,2)","v":0.021138767058150425},{"$f":"TTEST(T1922:V1922,W1922:Y1922,2,2)","v":0.8923529852344654},{"$f":"-LOG10(AB1922)","v":0.049463319149194045},{"$f":"AB1922*7808/AF1922","v":0.945770613371889},{"$f":"-LOG10(AD1922)","v":0.024214184345442754},7367]
["High","P42167","Lamina-associated polypeptide 2, isoforms beta/gamma [OS=Homo sapiens]",52,19,144,6,454,50.6,9.38,338.34,"","other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","TMPO","ENSG00000120802","Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RHOC GTPase cycle; RHOJ GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle","",3047.3,3217,2909.8,3044.2,2987.5,3001.7,1.0155755308078906,0.022297540342853476,0.631501680109386,0.19962548966721783,0.7982459314058744,0.09786328634627621,6177]
["High","P42285","Superkiller viralicidic activity 2-like 2 [OS=Homo sapiens]",36,35,115,34,1042,117.7,6.52,206.2,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus","other molecular function","MTREX","ENSG00000039123","","mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol","RNA degradation",4271.6,4301.1,4397.4,4808.7,5147.4,5068.4,0.8632633365503013,-0.21212737744917803,3.292434703463245E-3,2.4824828293371124,0.046571250298262715,1.331882102407676,552]
["High","P42575-1","caspase-2 [OS=Homo sapiens]",3,2,2,2,452,50.7,6.81,6.43,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","CASP2","ENSG00000106144; ENSPPAG00000028627; ENSPTRG00000019805; ENSPTRG00000047033","Apoptosis modulation and signaling; Parkinson's disease pathway; Apoptosis; Apoptosis modulation by HSP70; Acute viral myocarditis; Apoptosis modulation by HSP70","TP53 Regulates Transcription of Caspase Activators and Caspases; NOD1/2 Signaling Pathway; NADE modulates death signalling","Apoptosis",81.1,91.5,86.8,102.3,105.8,102.7,0.8346203346203345,-0.2608080241560109,0.0058943860233796,2.2295614256062333,0.06152856426543839,1.210923218812059,748]
["High","P42695","condensin-2 complex subunit D3 [OS=Homo sapiens]",14,15,27,15,1498,168.8,7.5,41.1,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","other molecular function","NCAPD3","ENSG00000151503","","Condensation of Prophase Chromosomes","",1050.7,1008.9,1119.1,1131.8,1106.4,1126.5,0.9447201830772431,-0.08204101451186674,0.13380133363219718,0.8735395578221744,0.3346319067905816,0.47543265188993766,3122]
["High","P42858","huntingtin [OS=Homo sapiens]",13,33,62,33,3142,347.4,6.2,114.75,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","HTT","ENSG00000197386","Mesodermal commitment pathway; Mesodermal commitment pathway; ERK pathway in Huntington's disease; Rett syndrome causing genes","Regulation of MECP2 expression and activity","Huntington disease; Pathways of neurodegeneration",2407.6,2516.8,2473.7,2503.4,2535.7,2555.3,0.9741520067418097,-0.037781186787181835,0.13637497346492186,0.8652653209061801,0.3378222692938166,0.47131172506506247,3152]
["High","P43155","Carnitine O-acetyltransferase [OS=Homo sapiens]",8,4,5,4,626,70.8,8.44,10.23,"other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","CRAT","ENSG00000095321","Fatty acid beta-oxidation","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","",263.6,263.6,254.8,227.3,234.4,238.1,1.1174621320377252,0.1602259429548653,3.1594314416297548E-3,2.5003910642104,0.0455985964810446,1.3410485246583341,541]
["High","P43304","Glycerol-3-phosphate dehydrogenase, mitochondrial [OS=Homo sapiens]",44,25,80,25,727,80.8,7.69,158.64,"other metabolic processes","other membranes;mitochondrion;other cell component","other molecular function","GPD2","ENSG00000115159","Fatty acid beta-oxidation","Triglyceride catabolism; Synthesis of PA","Glycerophospholipid metabolism",3289.8,3115.8,3492.7,3310.2,3733,3494.6,0.9393137087437605,-0.09032103023096412,0.26308370511565465,0.5799060504225096,0.4936692068115913,0.3065639615568216,4161]
["High","P45880","Voltage-dependent anion-selective channel protein 2 [OS=Homo sapiens]",68,16,150,15,294,31.5,7.56,373.23,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","VDAC2","ENSG00000165637","Alzheimer's disease and miRNA effects; Ferroptosis; Alzheimer's disease","Ub-specific processing proteases; Mitochondrial calcium ion transport","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy",6420.8,6409,7145,5318.8,6225.2,5881.1,1.1463234070392712,0.19701412254928719,0.07714899493518197,1.112669727370731,0.24269917504186175,0.6149316998748067,2482]
["High","P45984-1","Mitogen-activated protein kinase 9 [OS=Homo sapiens]",10,5,14,4,424,48.1,5.63,22.71,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","MAPK9","ENSG00000050748; ENSGGOG00000016519; ENSOCUG00000015542; ENSPPAG00000038007; ENSPTRG00000017633","IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Wnt signaling pathway and pluripotency; Splicing factor NOVA regulated synaptic proteins; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; CCL18 signaling pathway; Familial partial lipodystrophy (FPLD); Alzheimer's disease; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway; MAPK signaling pathway; Wnt signaling pathway","Oxidative Stress Induced Senescence; FCERI mediated MAPK activation; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors","Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; cAMP signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Mitophagy; Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Apoptosis; Necroptosis; Wnt signaling pathway; Osteoclast differentiation; Focal adhesion; Tight junction; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; Insulin signaling pathway; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Adipocytokine signaling pathway; Relaxin signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Measles; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Choline metabolism in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",363.1,317.6,357.2,360.7,346.6,333.8,0.99692632792239,-4.441200362348522E-3,0.950846162954014,0.02188974172138941,0.9754574747529814,0.010791659004147174,7611]
["High","P46087-2","Isoform 2 of Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase [OS=Homo sapiens]",44,30,141,30,808,88.9,9.23,295.98,"","","","NOP2","","","","",5469.9,5514.6,5643,5515.3,5272.3,5603.1,1.0144472170194074,0.02069380178713577,0.5188157166307701,0.2849868761835032,0.7206748115020553,0.1422606568178056,5621]
["High","P46736","Lys-63-specific deubiquitinase BRCC36 [OS=Homo sapiens]",27,8,23,8,316,36,5.92,53.29,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","BRCC3","ENSG00000185515","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","Homologous recombination; NOD-like receptor signaling pathway",815.9,623.1,749.2,743,742.3,745.2,0.9810356422326832,-0.027622542603668688,0.815338966290504,0.08866180158550532,0.9097122961983788,0.04109593507375757,6998]
["High","P46777","60S ribosomal protein L5 [OS=Homo sapiens]",64,20,329,20,297,34.3,9.72,573.24,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL5","ENSG00000122406","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",16401,16328.4,16117.8,15888.1,16224.6,16035.1,1.0145261050349133,0.02080598793327783,0.14554090767019898,0.8370149209156692,0.3507356194718869,0.455020126463646,3240]
["High","P46934-4","Isoform 4 of E3 ubiquitin-protein ligase NEDD4 [OS=Homo sapiens]",6,5,7,3,900,104.2,5.97,7.19,"","","","NEDD4","","","","",18.7,11.9,13.7,16.3,8.2,11.8,1.2203856749311295,0.2873371505592676,0.4385642740920931,0.35796674930374195,0.6581414284280344,0.18168077054114318,5203]
["High","P47895","Aldehyde dehydrogenase family 1 member A3 [OS=Homo sapiens]",20,11,19,8,512,56.1,7.25,35.56,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","ALDH1A3","ENSG00000184254","Ethanol effects on histone modifications; Vitamin A and carotenoid metabolism","RA biosynthesis pathway","Retinol metabolism; Metabolic pathways",527,558.1,575.3,608.3,593,576.1,0.9341735118712725,-0.09823755622937631,0.08247378228590575,1.0836840880337955,0.2524324939585857,0.5978547419849501,2551]
["High","P47897","glutamine--tRNA ligase [OS=Homo sapiens]",51,38,153,37,775,87.7,7.15,333.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;mitochondrion;other cell component","enzyme regulator activity;other molecular function","QARS1","ENSG00000172053","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis; Metabolic pathways",6810,6903.8,6787.7,5576.2,5933.5,5954,1.1739493921677535,0.23137021658908863,1.3697243495543008E-3,2.8633668237286836,0.03154810537262531,1.5010267172731302,339]
["High","P48200","iron-responsive element-binding protein 2 [OS=Homo sapiens]",4,4,4,4,963,105,7.05,6.34,"","","","","","","","",152.1,160.4,153.5,130.6,118.2,135.5,1.2125943273484259,0.27809697847884,0.009072837417012737,2.0422568715019627,0.07600935037772044,1.1191329791973088,932]
["High","P48444","Coatomer subunit delta [OS=Homo sapiens]",49,22,104,22,511,57.2,6.21,174.94,"transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","","ARCN1","ENSG00000095139","miR-517 relationship with ARCN1 and USP1","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",4892.2,4696,5137.3,4587.6,5061.1,4815.7,1.018051215397804,0.02581014131718425,0.6659208287029866,0.17657740101179017,0.8203707526842725,0.08598983120743652,6338]
["High","P48553","Trafficking protein particle complex subunit 10 [OS=Homo sapiens]",3,3,4,3,1259,142.1,6.04,10.65,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC10","ENSG00000160218","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",125.3,119.4,130.8,111,125,114,1.072857142857143,0.1014579856819431,0.18928119939544752,0.7228925207657321,0.40501715672229494,0.3925265794717449,3649]
["High","P48681","Nestin [OS=Homo sapiens]",55,73,259,73,1621,177.3,4.36,559.8,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;other molecular function","NES","ENSG00000132688","","","",11214.8,10419.7,10513.8,12483.3,9682.2,10028.2,0.9985897862004057,-2.0359443513230623E-3,0.9876192257279106,0.0054104643595144,0.9929604576981105,0.003068045910907806,7766]
["High","P49023","Paxillin [OS=Homo sapiens]",32,12,31,12,591,64.5,6.19,52.07,"cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PXN","ENSG00000089159","Integrin-mediated cell adhesion; Prolactin signaling pathway; Oncostatin M signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; 3q29 copy number variation syndrome; Regulation of actin cytoskeleton","VEGFA-VEGFR2 Pathway; GAB1 signalosome; Smooth Muscle Contraction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","Chemokine signaling pathway; VEGF signaling pathway; Focal adhesion; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Human papillomavirus infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis; Proteoglycans in cancer",1118.8,1153.5,1093.9,1176.3,1054.9,1102.7,1.0096883529799936,0.013910064273170184,0.7977336277124012,0.09814210028659849,0.8977665271228638,0.04683659113400409,6938]
["High","P49069","calcium signal-modulating cyclophilin ligand [OS=Homo sapiens]",22,5,9,5,296,32.9,8.05,27.55,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","CAMLG","ENSG00000164615","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",327.7,371.9,314.5,303.7,297.4,302,1.1229099767467612,0.16724227207784512,0.10142054195314718,0.9938740730759349,0.2853663393045669,0.5445972558759945,2775]
["High","P49327","Fatty acid synthase [OS=Homo sapiens]",60,115,750,114,2511,273.3,6.44,1825.21,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","FASN","ENSG00000169710","AMP-activated protein kinase (AMPK) signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway","ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism","Fatty acid biosynthesis; Metabolic pathways; Fatty acid metabolism; AMPK signaling pathway; Insulin signaling pathway; Alcoholic liver disease",30976.1,31040.1,32362.8,28370.4,30789.1,29945.9,1.0591838429545235,0.08295302020794838,0.10469698022545727,0.9800658444943544,0.2906057666549486,0.53669577200092,2813]
["High","P49406","39S ribosomal protein L19, mitochondrial [OS=Homo sapiens]",35,10,18,9,292,33.5,9.5,36.57,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPL19","ENSG00000115364","Cytoplasmic ribosomal proteins","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",933.9,945.5,938.8,861.4,1063.3,958.5,0.9774556048834628,-0.03289691683459474,0.7294236214429146,0.1370201767280178,0.8608433549314204,0.06507586861387266,6616]
["High","P49441","Inositol polyphosphate 1-phosphatase [OS=Homo sapiens]",14,3,4,3,399,44,5.26,7.09,"other metabolic processes;signal transduction","cytosol","other molecular function","INPP1","ENSG00000151689","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",30.6,32.1,34.6,31.9,36.1,34.2,0.952054794520548,-0.07088348615650976,0.3869904568034401,0.41229974456431273,0.6167833204166687,0.20986737936200792,4899]
["High","P49591","Serine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",47,24,116,24,514,58.7,6.43,211.34,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SARS1","ENSG00000031698","VEGFA-VEGFR2 signaling pathway","Cytosolic tRNA aminoacylation; Selenocysteine synthesis","Aminoacyl-tRNA biosynthesis",4128,3921.7,4248.5,4079.7,4143.2,4083.8,0.9993093193138698,-9.9678587073163331E-4,0.9782307680634115,0.00955868153721242,0.9877183288554399,0.005366887056626035,7733]
["High","P49736","DNA replication licensing factor mcm2 [OS=Homo sapiens]",58,46,213,46,904,101.8,5.52,476.82,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM2","ENSG00000073111","Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","DNA replication; Cell cycle",7749.4,7741.3,7979.7,7822.6,8441.5,8269.4,0.9566674139441989,-0.06391063689353581,0.15159810669403118,0.8193062225659002,0.35956197359264747,0.44422624444749703,3292]
["High","P49756-1","RNA-binding protein 25 [OS=Homo sapiens]",39,36,103,36,843,100.1,6.32,213.46,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RBM25","ENSG00000119707; ENSGGOG00000002415; ENSPPAG00000039402; ENSPTRG00000006509","","","Spliceosome",5102,4987.7,5062.7,5236.7,5087.4,5218.9,0.9748697162709904,-0.03671866807523093,0.08739083938437206,1.0585340892571984,0.26043804347831184,0.5842955759183085,2620]
["High","P49773","Histidine triad nucleotide-binding protein 1 [OS=Homo sapiens]",40,5,14,5,126,13.8,6.95,36.19,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","HINT1","ENSG00000169567","","","",1002,1023.9,919.9,1045.1,977,953.3,0.9900517577468578,-0.014424146773017975,0.8255660552469506,0.08324817221154429,0.9149779644241577,0.03858936499828407,7045]
["High","P49840","Glycogen synthase kinase-3 alpha [OS=Homo sapiens]",30,8,17,6,483,50.9,8.75,34.2,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","GSK3A","ENSG00000105723","IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation","XBP1(S) activates chaperone genes; Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein","Chemokine signaling pathway; Dopaminergic synapse; Non-alcoholic fatty liver disease; Shigellosis",306.5,287.1,309.6,281.8,313.8,288.2,1.021950667571849,0.03132555501599572,0.6198930255133368,0.2076832499173595,0.7902244478707157,0.1022495382952942,6125]
["High","P49915","GMP synthase [glutamine-hydrolyzing] [OS=Homo sapiens]",73,43,195,43,693,76.7,6.87,428.98,"other metabolic processes","cytosol","other molecular function","GMPS","ENSG00000163655","","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Drug metabolism; Metabolic pathways",7986.3,8301.6,8098.9,8352.5,9077.2,8701.7,0.9332374078694597,-0.09968395744725157,0.06377822696867042,1.1953275582888232,0.21529632346363106,0.6669633864008072,2313]
["High","P50148","Guanine nucleotide-binding protein G(Q) subunit alpha [OS=Homo sapiens]",12,5,10,4,359,42.1,5.68,22.41,"cell-cell signaling;stress response;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","GNAQ","ENSG00000156052","Thyroid stimulating hormone (TSH) signaling pathway; Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Circadian rhythm genes; Cell-type dependent selectivity of CCK2R signaling; Hippo signaling regulation pathways; Gastrin signaling pathway; PKC-gamma calcium signaling pathway in ataxia; GPR143 in melanocytes and retinal pigment epithelium cells; Airway smooth muscle cell contraction; Prostaglandin and leukotriene metabolism in senescence ; Alzheimer's disease; Calcium regulation in cardiac cells; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 2 and STAT3 signaling","G alpha (q) signalling events; Thrombin signalling through proteinase activated receptors (PARs); G-protein activation; ADP signalling through P2Y purinoceptor 1; Thromboxane signalling through TP receptor; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Apelin signaling pathway; Gap junction; Platelet activation; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Yersinia infection; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",288.2,274.4,282.1,277.3,326,283.7,0.9523111612175873,-0.07049505349881856,0.4223909888320864,0.3742853554890283,0.6459124247553724,0.18982636129862435,5106]
["High","P50395-1","Rab GDP dissociation inhibitor beta [OS=Homo sapiens]",74,32,218,24,445,50.6,6.47,449.1,"transport;signal transduction","non-structural extracellular;other membranes;cytosol;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","GDI2","ENSG00000057608; ENSNLEG00000035201","","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs","",9485.9,10024.9,10249.1,9106.4,10169.9,9595.9,1.0307458385575052,0.043688636627802147,0.4815579641142974,0.3173514302842301,0.6923227000192294,0.15969142841822218,5431]
["High","P50479-1","PDZ and LIM domain protein 4 [OS=Homo sapiens]",3,1,1,1,330,35.4,7.91,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","PDLIM4","ENSG00000131435; ENSPTRG00000017214","","","",115.5,92,117.4,101.4,102.6,110.7,1.032411820781697,0.04601856503105981,0.7150904180911577,0.14563904128232505,0.8520412001305905,0.0695394045798283,6553]
["High","P50552","Vasodilator-stimulated phosphoprotein [OS=Homo sapiens]",57,16,65,16,380,39.8,8.94,143.39,"cell organization and biogenesis;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","VASP","ENSG00000125753","Integrin-mediated cell adhesion; Focal adhesion","Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions","Rap1 signaling pathway; cGMP-PKG signaling pathway; Focal adhesion; Tight junction; Platelet activation; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration",2147,2211.9,2079.8,2182.5,2102.9,2065.9,1.013760962322674,0.019717515136061126,0.6008633615620291,0.22122427685970217,0.779196334010351,0.10835309940821473,6021]
["High","P50851-1","Lipopolysaccharide-responsive and beige-like anchor protein [OS=Homo sapiens]",19,35,60,1,2863,318.9,5.6,118.25,"other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","LRBA","ENSG00000198589","","","",2242.1,2193.4,2294.7,2142.3,2141.1,2116.9,1.0515444588534915,0.07250984789329538,0.022404935802688593,1.6496562961418346,0.12131604628806694,0.9160817518666095,1442]
["High","P50991","T-complex protein 1 subunit delta [OS=Homo sapiens]",71,31,355,31,539,57.9,7.83,816.82,"transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CCT4","ENSG00000115484","16p11.2 proximal deletion syndrome","Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; Folding of actin by CCT/TriC","",13101.4,12624.8,13559.8,12586.8,13789.3,13242.7,0.9915999474996718,-0.012169899846314395,0.813416039995686,0.08968726786340492,0.908475531438466,0.041686765333777444,6991]
["High","P51148","Ras-related protein Rab-5C [OS=Homo sapiens]",74,11,46,9,216,23.5,8.41,119.88,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","RAB5C","ENSG00000108774","Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells","Clathrin-mediated endocytosis; Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Golgi Associated Vesicle Biogenesis; TBC/RABGAPs","Ras signaling pathway; Endocytosis; Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection; Amoebiasis; Tuberculosis",1535.6,1450,1527.2,1207,1423,1317.7,1.1431466423487096,0.19301048370922694,0.05043262235989132,1.2972884491158894,0.18977248934266577,0.7217667455053653,2075]
["High","P51511","Matrix metalloproteinase-15 [OS=Homo sapiens]",7,3,4,3,669,75.8,7.46,11.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes","enzyme regulator activity;other molecular function","MMP15","ENSG00000102996","Matrix metalloproteinases; Epithelial to mesenchymal transition in colorectal cancer","Collagen degradation; Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action",172,185.1,173.2,216.2,221.6,220.2,0.8059270516717324,-0.31127883548185814,6.8669531926587618E-4,3.16323591288529,0.02331181327316505,1.6324239442442474,230]
["Medium","P51512-1","Matrix metalloproteinase-16 [OS=Homo sapiens]",1,1,1,1,607,69.5,8.54,2,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","MMP16","ENSCANG00000029811; ENSCATG00000039014; ENSCSAG00000012941; ENSG00000156103; ENSGGOG00000027756; ENSMFAG00000040046; ENSMMUG00000013193; ENSMNEG00000003965; ENSPANG00000010068; ENSRBIG00000031261; ENSRROG00000034264","Matrix metalloproteinases","Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action; MicroRNAs in cancer",86.1,85.2,82.8,80,68,78.3,1.1228457799381353,0.16715979078646245,0.07511098433447688,1.1242965465242456,0.23859502265402582,0.6223386204160455,2458]
["High","P51648","Fatty aldehyde dehydrogenase [OS=Homo sapiens]",24,11,36,11,485,54.8,7.88,85.84,"other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ALDH3A2","ENSG00000072210","Fragile X syndrome; Tryptophan metabolism; Fluoroacetic acid toxicity","RND2 GTPase cycle; RND1 GTPase cycle","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease",1516.6,1551.2,1672,1524.5,1652.8,1604,0.9913203522054672,-0.012576744989952383,0.8293598315994275,0.08125700265558379,0.9170997826268701,0.03758340949172777,7061]
["High","P51688","N-sulphoglucosamine sulphohydrolase [OS=Homo sapiens]",12,4,8,4,502,56.7,6.95,19.39,"protein metabolism;other metabolic processes","other cytoplasmic organelle","other molecular function","SGSH","ENSG00000181523","Glycosaminoglycan degradation","HS-GAG degradation; MPS IIIA - Sanfilippo syndrome A","Glycosaminoglycan degradation; Metabolic pathways; Lysosome",169.2,192.3,176.6,157.6,160,161.1,1.1240860664299142,0.16875250073500736,0.04526603447417045,1.3442275501572825,0.17977476967157827,0.7452712589947639,1966]
["High","P51797-1","Chloride transport protein 6 [OS=Homo sapiens]",4,2,2,2,869,97.2,6.81,5.36,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","CLCN6","ENSG00000011021","","Signaling by BRAF and RAF1 fusions; Stimuli-sensing channels","",28.3,23.7,22.3,31.1,30.3,24.9,0.8609501738122827,-0.2159983486403589,0.20707701612752802,0.6838681016034794,0.42967242676687184,0.3668625152647084,3763]
["Medium","P51825","AF4/FMR2 family member 1 [OS=Homo sapiens]",1,1,1,1,1210,131.3,9.2,2.1,"other biological processes","nucleus","","AFF1","ENSG00000172493","","","Transcriptional misregulation in cancer",66.1,61.7,62.8,66.1,77.4,89.2,0.8190803609798023,-0.28792309149540674,0.10794678396217197,0.966790291989204,0.2948053477357953,0.5304646426885574,2859]
["High","P51948-1","CDK-activating kinase assembly factor MAT1 [OS=Homo sapiens]",28,6,12,6,309,35.8,6.09,32.73,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","enzyme regulator activity;kinase activity;other molecular function","MNAT1","ENSCANG00000033478; ENSCATG00000030975; ENSCSAG00000014164; ENSG00000020426; ENSMFAG00000000901; ENSMMUG00000001642; ENSNLEG00000013781; ENSPPAG00000033622; ENSPTRG00000006412; ENSRROG00000035712","Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; Eukaryotic transcription initiation; G1 to S cell cycle control","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin D associated events in G1; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Basal transcription factors; Nucleotide excision repair",448.9,446.2,434.8,419.6,413.7,413.9,1.0663085311096856,0.09262493518863596,0.004331503036768695,2.363361376785829,0.051871741888174804,1.285069167859114,652]
["High","P51991-1","Heterogeneous nuclear ribonucleoprotein A3 [OS=Homo sapiens]",52,24,241,22,378,39.6,9.01,505.27,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","transporter activity;nucleic acid binding activity","HNRNPA3; HNRPA3","ENSG00000170144; ENSGGOG00000006130; ENSHGLG00000005451; ENSPPAG00000023768; ENSPTRG00000012676; ENSSTOG00000025125","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Spliceosome; Amyotrophic lateral sclerosis",10110.1,13211.2,10306.8,11188.2,11300.1,11533.5,0.988428007924331,-0.016792203685404735,0.9026680547962875,0.044471926844771054,0.9507665144812375,0.021926122307877452,7413]
["High","P52306-1","Rap1 GTPase-GDP dissociation stimulator 1 [OS=Homo sapiens]",27,11,23,11,607,66.3,5.31,47.1,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;ER/Golgi","enzyme regulator activity","RAP1GDS1","ENSG00000138698","","RHOT2 GTPase cycle; RHOT1 GTPase cycle","",1024.1,967.2,1031.4,1022.7,990.1,1008.9,1.0003309395373463,4.7736584410388813E-4,0.9888320703062207,0.004877456766623826,0.9930290424374238,3.0380498068635717E-3,7775]
["High","P52597","Heterogeneous nuclear ribonucleoprotein F [OS=Homo sapiens]",66,18,246,16,415,45.6,5.58,405.27,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPF","ENSG00000169813","MECP2 and associated Rett syndrome","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",5849.3,6135.7,5730.9,5880.9,5800.1,5808.3,1.012956493398821,0.01857221154707948,0.5719909946516821,0.2426108086263269,0.7598002188227856,0.11930058570428528,5878]
["High","P52739","Zinc finger protein 131 [OS=Homo sapiens]",23,9,13,9,623,71.4,5.19,20.41,"other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","ZNF131","ENSG00000172262","","SUMOylation of transcription cofactors","",281.7,264.4,292.2,258,288.5,255.2,1.0456529874017713,0.06440415520242465,0.4139084925107633,0.38309566272046675,0.6389477084863662,0.19453468307021726,5058]
["High","P52789","Hexokinase-2 [OS=Homo sapiens]",46,37,122,34,917,102.3,6.05,291.02,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component","kinase activity;other molecular function","HK2","ENSG00000159399","Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis","Glycolysis","Glycolysis / Gluconeogenesis; Fructose and mannose metabolism; Galactose metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Neomycin, kanamycin and gentamicin biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of nucleotide sugars; HIF-1 signaling pathway; Insulin signaling pathway; Type II diabetes mellitus; Carbohydrate digestion and absorption; Shigellosis; Central carbon metabolism in cancer",4735.7,4678.1,4718.3,4419.6,4448.5,4637.6,{"$f":"AVERAGE(T2242:V2242)/AVERAGE(W2242:Y2242)","v":1.0463804171572002},{"$f":"LOG(Z2242,2)","v":0.0654074463934357},{"$f":"TTEST(T2242:V2242,W2242:Y2242,2,2)","v":0.04140938962925023},{"$f":"-LOG10(AB2242)","v":1.3829011709127912},{"$f":"AB2242*7808/AF2242","v":0.1713431447934212},{"$f":"-LOG10(AD2242)","v":0.7661332664190873},1887]
["High","P52907","F-actin-capping protein subunit alpha-1 [OS=Homo sapiens]",67,13,143,11,286,32.9,5.69,385.37,"cell organization and biogenesis","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity","CAPZA1","ENSG00000116489","","MHC class II antigen presentation; Advanced glycosylation endproduct receptor signaling; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production","Endocytosis",4905.9,5156.2,4790,4934.7,4950,5110.2,0.9904767620991136,-0.013804966918122372,0.7157881414245912,0.14521550091182114,0.8522222946390986,0.06944710858653215,6558]
["High","P53367","Arfaptin-1 [OS=Homo sapiens]",54,16,45,1,373,41.7,6.7,91.35,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","ARFIP1","ENSG00000164144","","","",1531.5,1525.3,1537.1,1469.7,1349.3,1384.4,1.092900984916972,0.128162701064723,0.02226494071675001,1.6523784568957771,0.12106173893898613,0.9169930921434233,1436]
["High","P53611","Geranylgeranyl transferase type-2 subunit beta [OS=Homo sapiens]",20,7,20,7,331,36.9,5.03,29.64,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RABGGTB","ENSG00000137955","","RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain","",589.7,584.1,643.1,506.2,584.6,537.4,1.1158948532121362,0.15820109356851692,0.10032134452685351,0.9986066559722869,0.2836021209506417,0.547290525556264,2762]
["High","P53667-1","LIM domain kinase 1 [OS=Homo sapiens]",8,3,6,3,647,72.5,6.98,12.9,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","LIMK1","ENSG00000106683; ENSPTRG00000019286; ENSPTRG00000045946","Microtubule cytoskeleton regulation; VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; G13 signaling pathway","Regulation of actin dynamics for phagocytic cup formation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Axon guidance; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Human immunodeficiency virus 1 infection",189,127.1,215.5,197.9,209.7,212.2,0.8576960309777348,-0.22146165031004109,0.3304198937930092,0.4809338127304902,0.5624413627067398,0.24992274820383734,4587]
["High","P53778","Mitogen-activated protein kinase 12 [OS=Homo sapiens]",10,3,3,3,367,41.9,6.39,4.87,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","MAPK12","ENSG00000188130","Integrin-mediated cell adhesion; Parkinson's disease pathway; S1P receptor signal transduction; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway","p38MAPK events; Negative regulation of MAPK pathway; VEGFA-VEGFR2 Pathway; Myogenesis; NOD1/2 Signaling Pathway; DSCAM interactions; Activation of PPARGC1A (PGC-1alpha) by phosphorylation","Endocrine resistance; MAPK signaling pathway; Rap1 signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; VEGF signaling pathway; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Leukocyte transendothelial migration; Thermogenesis; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Relaxin signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Proteoglycans in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",64,77.8,53.7,65.3,61.3,65.2,1.0192909280500522,0.027565887176583852,0.8706139348252118,0.06017438591596994,0.9345275781021795,0.029407877976027653,7274]
["High","P53985","Monocarboxylate transporter 1 [OS=Homo sapiens]",15,13,93,13,500,53.9,8.66,223.41,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;other molecular function","SLC16A1","ENSG00000155380; ENSG00000281917","Photodynamic therapy-induced HIF-1 survival signaling; Fragile X syndrome","Basigin interactions; Pyruvate metabolism; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)","",7294.8,8008.1,6710.7,6582.2,6018.1,6510.3,1.1519052253723068,0.20402202189299953,0.0800610309572563,1.096578821723236,0.24806211496597505,0.6054395578461447,2520]
["High","P54252","Ataxin-3 [OS=Homo sapiens]",12,3,5,3,364,41.8,4.91,7.43,"","","","","","","","",130.4,128,140.4,162.5,166.1,150.9,0.8316996871741396,-0.26586540550729754,0.010674208416872522,1.9716643217297325,0.08367893505917735,1.0773838554947959,996]
["High","P54578","Ubiquitin carboxyl-terminal hydrolase 14 [OS=Homo sapiens]",51,21,101,21,494,56,5.3,239.24,"protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","USP14","ENSG00000101557","","Ub-specific processing proteases","",3932.4,3708.8,3830.5,3930.9,3761.5,3838.1,0.9949004813321192,-0.007375873019224237,0.8208979350599976,0.08571083678523429,0.9135648627349574,0.03926061248458303,7016]
["High","P54687","Branched-chain-amino-acid aminotransferase, cytosolic [OS=Homo sapiens]",47,16,148,2,386,42.9,5.3,289.85,"cell cycle OR cell proliferation;other metabolic processes","cytosol;mitochondrion","other molecular function","BCAT1","ENSG00000060982","Amino acid metabolism; One-carbon metabolism and related pathways","Branched-chain amino acid catabolism","Cysteine and methionine metabolism; Valine, leucine and isoleucine degradation; Valine, leucine and isoleucine biosynthesis; Pantothenate and CoA biosynthesis; Metabolic pathways; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors",5756.9,5983.4,5882,6000.2,5954,6058.4,0.9783318343825987,-0.03160420780877383,0.14562207327287358,0.8367727900365249,0.35082293986874324,0.45491201641009954,3241]
["High","P54764","Ephrin type-A receptor 4 [OS=Homo sapiens]",5,3,3,3,986,109.8,6.61,10.23,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","EPHA4","ENSG00000116106","Spinal cord injury; Gene regulatory network modelling somitogenesis ; Fragile X syndrome; Somitogenesis in the context of spondylocostal dysostosis","EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse","Axon guidance",102.4,109.4,93.5,106.2,126.4,119.7,0.8665909736020436,-0.20657688528818388,0.10541512404331524,0.9770970758658541,0.2913562083292762,0.5355757233626761,2825]
["High","P54920","alpha-soluble nsf attachment protein [OS=Homo sapiens]",59,15,77,15,295,33.2,5.36,211.67,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","NAPA","ENSG00000105402","Synaptic vesicle pathway; VEGFA-VEGFR2 signaling pathway","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network; COPI-dependent Golgi-to-ER retrograde traffic; Intra-Golgi traffic","Synaptic vesicle cycle",2653.1,2624.7,2754.2,2551.9,2687,2673.1,1.0151668351870575,0.021716843191661027,0.5295584867991425,0.27608606748962505,0.7288546915084972,0.13735904639569183,5673]
["High","P55061","Bax inhibitor 1 [OS=Homo sapiens]",3,1,2,1,237,26.5,8.54,4.76,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","TMBIM6","ENSG00000139644","","","Pathogenic Escherichia coli infection",169.5,188.3,209.4,98.8,115.5,100.9,1.7994923857868022,0.84758999778314,2.6810887109796205E-3,2.5716888159867035,0.04263531701696309,1.3702305034510367,491]
["High","P55145","Mesencephalic astrocyte-derived neurotrophic factor [OS=Homo sapiens]",19,4,7,4,182,20.7,8.69,13.77,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","MANF","ENSG00000145050","Orexin receptor pathway","Platelet degranulation","",282.9,303.9,304.3,353.3,278.9,272.8,0.9846408839779004,-0.022330450898968256,0.8712530570909294,0.059855685019739625,0.9345712144203842,0.029387599741098464,7279]
["High","P55265-1","Double-stranded RNA-specific adenosine deaminase [OS=Homo sapiens]",49,54,263,54,1226,136,8.65,499.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ADAR","ENSG00000160710","Measles virus infection; Cytosolic DNA-sensing pathway","Interferon alpha/beta signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins","Cytosolic DNA-sensing pathway; Measles; Influenza A; Coronavirus disease",13450.7,13190.4,13462.1,13820.6,14198.2,14318.5,0.9472309287554944,-0.07821190662141646,0.01291686385365937,1.8888429179493977,0.09278277182094972,1.032532657377057,1087]
["High","P55786","puromycin-sensitive aminopeptidase [OS=Homo sapiens]",50,37,153,37,919,103.2,5.72,323.71,"protein metabolism;other metabolic processes;stress response","cytosol;nucleus;other cell component","other molecular function","NPEPPS","ENSG00000141279","","Antigen processing: Ubiquitination & Proteasome degradation","",6565.3,6694.3,6755.9,6799.8,7042.9,6932.3,0.9634416365824308,-0.05373082137456477,0.04810067246883681,1.317848851953329,0.18546669167243346,0.7317340748453808,2025]
["High","P55854","Small ubiquitin-related modifier 3 [OS=Homo sapiens]",20,2,6,1,103,11.6,5.49,17.4,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SUMO3","ENSG00000184900","Exercise-induced circadian regulation","SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; SUMOylation of immune response proteins; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed","Nucleocytoplasmic transport; Fluid shear stress and atherosclerosis",381,389.3,395,415.1,349.9,413.1,0.9891350479585774,-0.015760587331583552,0.8543065642978919,0.06838625660391216,0.9295464958246851,0.031728881981312414,7176]
["High","P56270-2","Isoform 2 of Myc-associated zinc finger protein [OS=Homo sapiens]",14,7,19,5,493,51,9.1,47.84,"","","","MAZ","","","","",679.8,714,669.4,764.4,772.1,862.9,0.8598816370759355,-0.21779000874207174,0.031085371571181644,1.5074439370347874,0.1450774544099141,0.8384000733385466,1673]
["High","P56747","Claudin-6 [OS=Homo sapiens]",25,5,20,5,220,23.3,8,42.93,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CLDN6","ENSG00000184697","Epithelial to mesenchymal transition in colorectal cancer","Tight junction interactions","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Pathogenic Escherichia coli infection; Hepatitis C",797.9,829.5,870.9,664.2,636.2,692.3,1.253726100265971,0.32622219905767064,3.1893167526303506E-3,2.4963023458909195,0.04586037790890935,1.3385623708211307,543]
["High","P57060","RWD domain-containing protein 2B [OS=Homo sapiens]",5,1,1,1,319,36.3,5.87,4.78,"","","","RWDD2B","ENSG00000156253","","","",70.3,67,71.5,53.4,59.8,66.5,{"$f":"AVERAGE(T2370:V2370)/AVERAGE(W2370:Y2370)","v":1.1619365609348917},{"$f":"LOG(Z2370,2)","v":0.21653130305994295},{"$f":"TTEST(T2370:V2370,W2370:Y2370,2,2)","v":0.07304247017282853},{"$f":"-LOG10(AB2370)","v":1.136424548120407},{"$f":"AB2370*7808/AF2370","v":0.2343120818033875},{"$f":"-LOG10(AD2370)","v":0.6302053173558176},2434]
["High","P57081-1","tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 [OS=Homo sapiens]",10,2,2,2,412,45.5,7.11,3.57,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","","WDR4","ENSG00000160193","","tRNA modification in the nucleus and cytosol","",17.7,23.4,16.2,23.2,20.8,22.7,0.8590704647676161,-0.21915162242768035,0.24678272538214996,0.6076852438842578,0.4762430844745,0.3221713176604083,4046]
["High","P57772","selenocysteine-specific elongation factor [OS=Homo sapiens]",9,5,17,5,596,65.3,8.35,38.67,"protein metabolism;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EEFSEC","ENSG00000132394; ENSG00000284869","","Selenocysteine synthesis","",1636,1686.1,1801.6,1401.3,1404.4,1386.9,1.2220817631064254,0.28934081157404157,3.2597283761215106E-3,2.4868185869462565,0.046192303377054,1.3354303811394064,551]
["High","P58107","epiplakin [OS=Homo sapiens]",32,43,92,40,5090,555.3,5.6,194.31,"","","","","","","","",2613.2,2634.8,2710.7,2157.3,2117.2,2129.1,1.2428477731276157,0.31364960258273406,8.3574707788029165E-5,4.077925133207046,0.01087585530681553,1.9635365789320542,60]
["High","P60033","CD81 antigen [OS=Homo sapiens]",18,2,18,2,236,25.8,5.29,45.32,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","CD81","ENSG00000110651","B cell receptor signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; IL-18 signaling pathway; 16p11.2 distal deletion syndrome","Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","B cell receptor signaling pathway; Malaria; Hepatitis C",531.4,639.7,553,429.5,414.1,447.5,1.3353729378049726,0.41724270849302103,0.013839501409907992,1.8588795557482025,0.09648109554335857,1.0155577737597488,1120]
["High","P60660","Myosin light polypeptide 6 [OS=Homo sapiens]",39,6,24,5,151,16.9,4.65,59.47,"developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL6","ENSG00000092841","Ciliary landscape","Smooth Muscle Contraction; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; RHO GTPases activate PKNs","Vascular smooth muscle contraction; Tight junction; Oxytocin signaling pathway",970.2,981.6,776.5,827.5,755.1,729,1.1802647516871432,0.2391105147596453,0.12896425719289614,0.889530638962786,0.32725151776474914,0.48511833055160897,3077]
["High","P60763","Ras-related C3 botulinum toxin substrate 3 [OS=Homo sapiens]",26,5,33,1,192,21.4,8.15,80.24,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","RAC3","ENSG00000169750","Integrin-mediated cell adhesion; RalA downstream regulated genes; Focal adhesion; MAPK signaling pathway; Microglia pathogen phagocytosis pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Regulation of actin cytoskeleton","RAC3 GTPase cycle; PCP/CE pathway","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Wnt signaling pathway; Axon guidance; VEGF signaling pathway; Focal adhesion; Adherens junction; Natural killer cell mediated cytotoxicity; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Regulation of actin cytoskeleton; Yersinia infection; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer; Choline metabolism in cancer; Viral myocarditis; Fluid shear stress and atherosclerosis",60.2,96.7,63.7,60.2,61,77.4,1.1107754279959718,0.15156716806300877,0.6003156879436402,0.2216203071549863,0.7790036382688953,0.10846051398800667,6017]
["High","P61006","Ras-related protein Rab-8A [OS=Homo sapiens]",31,6,18,3,207,23.7,9.07,30.45,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB8A","ENSG00000167461","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape; Joubert syndrome","Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB geranylgeranylation; Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs; VxPx cargo-targeting to cilium","Autophagy; Endocytosis; AMPK signaling pathway; Tight junction; Pancreatic secretion; Amyotrophic lateral sclerosis; Pathways of neurodegeneration",251.1,260.1,196.4,225.7,213.7,248.2,1.0290866783013382,0.04136450321239758,0.7801012127708882,0.10784904692968947,0.8881642270800664,0.05150672304997942,6858]
["High","P61088","ubiquitin-conjugating enzyme E2 N [OS=Homo sapiens]",48,6,56,6,152,17.1,6.57,137.06,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2N","ENSG00000177889","IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway; 3q29 copy number variation syndrome","ISG15 antiviral mechanism; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Nonhomologous End-Joining (NHEJ); Aggrephagy; E3 ubiquitin ligases ubiquitinate target proteins; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; Formation of Incision Complex in GG-NER; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Ubiquitin mediated proteolysis; Shigellosis",3190.6,3156.3,3082.1,3086.5,3127,2980.8,1.0255266850113658,0.036365032366454046,0.2215383654856364,0.6545510528454783,0.4473161514641451,0.3493854202599084,3867]
["High","P61158","actin-related protein 3 [OS=Homo sapiens]",58,22,178,18,418,47.3,5.88,454.13,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ACTR3","ENSG00000115091","Physico-chemical features and toxicity-associated pathways","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Clathrin-mediated endocytosis","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",7883.6,8092.1,8070.6,8384.7,8381.1,8435.3,0.9541766034022325,-0.0676717832972747,4.9249252847443255E-3,2.3076003537286818,0.05556909916659493,1.255166643526804,692]
["High","P61289-1","Proteasome activator complex subunit 3 [OS=Homo sapiens]",54,15,134,15,254,29.5,5.95,309.53,"cell cycle OR cell proliferation;protein metabolism;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","HEL-S-283; LOC101359250; LOC103001388; LOC111151323; LOC111166421; Psme3; PSME3","ENSBTAG00000019918; ENSCAFG00000014716; ENSCATG00000043580; ENSCCAG00000025926; ENSCGRG00001014333; ENSCGRG00015000348; ENSECAG00000012620; ENSG00000131467; ENSGGOG00000010707; ENSLAFG00000013446; ENSMLUG00000004084; ENSMMUG00000012685; ENSMNEG00000003232; ENSMPUG00000010027; ENSMUSG00000078652; ENSNVIG00000013505; ENSOARG00000003731; ENSOGAG00000009420; ENSPPAG00000043945; ENSPTRG00000009225; ENSPTRG00000049975; ENSRBIG00000001980; ENSRNOG00000051344; ENSSBOG00000024784; ENSSSCG00000017385; ENSSSCG00005010026; ENSSSCG00015075406; ENSSSCG00025054060; ENSSSCG00030072129; ENSSSCG00035013193; ENSSSCG00040025703; ENSSSCG00045007466; ENSSSCG00050060716; ENSSSCG00055025037; ENSSSCG00060042579; ENSSSCG00065003129; ENSSSCG00070012475; ENSSSUG00005017981; ENSSTOG00000028833; ENSTSYG00000002969; ENSUAMG00000013177; ENSUMAG00000025062","Proteasome degradation; Proteasome degradation; Proteasome degradation; Proteasome degradation","Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Hedgehog ligand biogenesis; Hedgehog 'on' state; Regulation of expression of SLITs and ROBOs; ER-Phagosome pathway; Degradation of beta-catenin by the destruction complex; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Downstream TCR signaling; FCERI mediated NF-kB activation; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; FCERI mediated NF-kB activation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; UCH proteinases; ABC-family proteins mediated transport; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Hedgehog ligand biogenesis; Degradation of beta-catenin by the destruction complex; Downstream TCR signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of RUNX3 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Regulation of RAS by GAPs; Autodegradation of the E3 ubiquitin ligase COP1; Neddylation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Separation of Sister Chromatids; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX3 expression and activity; Regulation of PTEN stability and activity; Antigen processing: Ubiquitination & Proteasome degradation","Proteasome; Antigen processing and presentation; Hepatitis C",3408.5,3208.6,3509.2,3287.3,3481.8,3373.2,0.9984224485570333,-2.2777227286515946E-3,0.9618303736630327,0.016901512450434822,0.9795189197288325,0.008987171048033898,7667]
["High","P61326","Protein mago nashi homolog [OS=Homo sapiens]",42,10,73,10,146,17.2,6.11,194.65,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","","MAGOH","ENSG00000162385","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",4206.7,3905.3,4464.2,3706.2,4617.5,4110.7,1.0114038473911084,0.01635917161571804,0.8858898732778058,0.052620262763510124,0.9422460333133234,0.025835682176326397,7341]
["High","P61803","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [OS=Homo sapiens]",19,2,9,2,113,12.5,7.08,17.53,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity","DAD1","ENSG00000129562","","Asparagine N-linked glycosylation; Maturation of spike protein","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum",343,377.9,413.8,349.6,386.5,366.2,1.0293930871813481,0.04179399937004959,0.6638723307517396,0.17791543174809665,0.8190101372269841,0.08671072276400783,6329]
["High","P61966","AP-1 complex subunit sigma-1A [OS=Homo sapiens]",16,2,4,2,158,18.7,5.73,11.33,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","AP1S1","ENSG00000106367","","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","Lysosome; Human immunodeficiency virus 1 infection",85.9,100.8,92.6,82.2,84.4,99,1.0515813253012045,0.07256042693302472,0.5391262816133919,0.2683094964379929,0.7363124028052063,0.13293788399363002,5717]
["High","P61978-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein K [OS=Homo sapiens]",65,30,512,1,440,48.5,5.54,787.75,"","","","HNRNPK","","","","",21871.2,22726.2,21175.7,24622.1,23389.7,23848.8,0.9152873758359935,-0.1277033125828695,0.02422111417222268,1.6158058831698945,0.12591109151578872,0.8999360111794087,1502]
["High","P62191","26S proteasome regulatory subunit 4 [OS=Homo sapiens]",64,24,191,22,440,49.2,6.21,407.77,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMC1","ENSG00000100764","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; N-glycan trimming in the ER and Calnexin/Calreticulin cycle","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human papillomavirus infection; Epstein-Barr virus infection; Viral carcinogenesis",6225.2,6369.1,6241.5,6483.3,6297.4,6270.1,0.9887143846977553,-0.016374272882569332,0.4261059037160112,0.3704824485887407,0.6499384442693135,0.18712777348035067,5119]
["High","P62263","40S ribosomal protein S14 [OS=Homo sapiens]",38,7,101,7,151,16.3,10.05,285.12,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","RPS14","ENSG00000164587","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); rRNA modification in the nucleus and cytosol","Ribosome; Coronavirus disease",3790.1,4091.4,3734.8,3388.7,3818.8,3816.2,1.0537569055761675,0.07554208559947835,0.33610953294387536,0.47351916963046686,0.5679167351711273,0.2457153334905364,4621]
["High","P62306","Small nuclear ribonucleoprotein F [OS=Homo sapiens]",15,1,10,1,86,9.7,4.67,8.85,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","SNRPF","ENSG00000139343","mRNA processing","snRNP Assembly; mRNA Splicing - Major Pathway; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","Spliceosome",284.5,257.1,286.1,239.8,273.2,236.3,1.104630988922995,0.14356450594042236,0.15775557647368474,0.8020152800144473,0.3668122516696041,0.4355561671578419,3358]
["High","P62316","Small nuclear ribonucleoprotein Sm D2 [OS=Homo sapiens]",56,6,37,6,118,13.5,9.91,74.8,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","SNRPD2","ENSG00000125743","mRNA processing","mRNA Splicing - Major Pathway; snRNP Assembly; mRNA Splicing - Minor Pathway","Spliceosome",1520.8,1638.4,1528.5,1944.8,1532.4,1478,0.94601630610268,-0.08006304395405735,0.5894093448738607,0.22958298284819217,0.7712599572272674,0.11279921603365474,5967]
["High","P62487","DNA-directed RNA polymerase II subunit rpb7 [OS=Homo sapiens]",51,6,18,6,172,19.3,5.54,34.5,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR2G","ENSG00000168002","Pyrimidine metabolism; Eukaryotic transcription initiation","Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; mRNA Splicing - Major Pathway; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Inhibition of DNA recombination at telomere; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","RNA polymerase; Huntington disease",431.4,392.8,406.9,426.7,455.7,441.3,0.9300445720329379,-0.10462823639788858,0.09288515294425921,1.032053699458319,0.27122186768465817,0.5666752977256492,2674]
["High","P62699","Protein yippee-like 5 [OS=Homo sapiens]",23,2,4,2,121,13.8,7.31,8.83,"cell cycle OR cell proliferation","non-structural extracellular;cytoskeleton;nucleus;other cell component","other molecular function","YPEL5","ENSG00000119801","Ciliary landscape","Neutrophil degranulation","",94.3,99.3,91.3,87.2,81.6,81.5,1.1382341190571312,0.186797330635519,0.018363509967475232,1.7360443049531187,0.11210499282724519,0.9503750447731372,1279]
["High","P62820","Ras-related protein Rab-1A [OS=Homo sapiens]",78,14,103,5,205,22.7,6.21,234.8,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB1A","ENSG00000138069","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization","Autophagy; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Legionellosis",5389.6,5569.2,6144.9,4801.1,5890.9,5316.3,1.0684270034919385,0.09548834431253363,0.40055622044586603,0.3973365194902351,0.6270134260708343,0.20272315963810472,4988]
["High","P62851","40S ribosomal protein S25 [OS=Homo sapiens]",37,5,10,5,125,13.7,10.11,15.49,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","other molecular function","RPS25","ENSG00000118181; ENSG00000280831","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",974.2,924.9,1017.3,1333.7,940.5,800.8,0.9484227642276422,-0.07639780380490697,0.7601742763320997,0.11908683064983286,0.8777640860102092,0.05662219242094762,6762]
["High","P62873","Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [OS=Homo sapiens]",52,11,53,6,340,37.4,6,145.37,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","cytoskeletal activity;other molecular function","GNB1","ENSG00000078369","Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells; Estrogen signaling pathway","G alpha (q) signalling events; Thrombin signalling through proteinase activated receptors (PARs); G alpha (i) signalling events; Inactivation, recovery and regulation of the phototransduction cascade; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (12/13) signalling events; Olfactory Signaling Pathway; G alpha (z) signalling events; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Sensory perception of sweet, bitter, and umami (glutamate) taste; Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation; Activation of the phototransduction cascade","Ras signaling pathway; Chemokine signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Olfactory transduction; Phototransduction; Relaxin signaling pathway; Morphine addiction; Alcoholism; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",2350.5,2383.3,2481,2189.9,2401.3,2411,1.0303618862643167,0.04315113335317212,0.436712203607539,0.3598046718630404,0.6570036388762359,0.18243222505286286,5190]
["High","P62913","60S ribosomal protein L11 [OS=Homo sapiens]",33,6,50,6,178,20.2,9.6,106.77,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL11","ENSG00000142676","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",2751.7,2601.7,2572.4,2436.9,2728,2464.3,1.03887694646883,0.055024779138387804,0.41235024094012246,0.3847337473384274,0.6381824938078248,0.19505511325272135,5045]
["High","P62979","Ubiquitin-40S ribosomal protein S27a [OS=Homo sapiens]",63,11,613,11,156,18,9.64,1106.78,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle","other molecular function","RPS27A","ENSG00000143947","Cytoplasmic ribosomal proteins","Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Glycogen synthesis; Cargo recognition for clathrin-mediated endocytosis; InlA-mediated entry of Listeria monocytogenes into host cells; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Stimuli-sensing channels; Negative regulation of MAPK pathway; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oncogene Induced Senescence; ISG15 antiviral mechanism; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Orc1 removal from chromatin; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Regulation of PLK1 Activity at G2/M Transition; Peroxisomal protein import; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of PTEN stability and activity; Downregulation of ERBB4 signaling; Regulation of PTEN localization; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Oxidative Stress Induced Senescence; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Regulation of TP53 Degradation; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; ER Quality Control Compartment (ERQC); Deactivation of the beta-catenin transactivating complex; Circadian Clock; Regulation of signaling by CBL; Metalloprotease DUBs; Regulation of necroptotic cell death; Cyclin D associated events in G1; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Inactivation of CSF3 (G-CSF) signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Regulation of BACH1 activity; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Negative regulators of DDX58/IFIH1 signaling; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Formation of TC-NER Pre-Incision Complex; Modulation by Mtb of host immune system; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Formation of Incision Complex in GG-NER; Iron uptake and transport; Myoclonic epilepsy of Lafora; DNA Damage Recognition in GG-NER; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Ribosome; Ubiquitin mediated proteolysis; Mitophagy; Parkinson disease; Pathways of neurodegeneration; Shigellosis; Kaposi sarcoma-associated herpesvirus infection; Coronavirus disease",19564.6,18927,18703.7,19506.8,17752.8,18028.3,1.034499411263586,0.048932824156504705,0.3508822935701589,0.454838546856679,0.5831606956568328,0.23421175463963062,4698]
["High","P63096-1","Guanine nucleotide-binding protein G(i) subunit alpha-1 [OS=Homo sapiens]",30,9,17,4,354,40.3,5.97,37.11,"cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","Gnai1; GNAI1; LOC101343271; LOC111155312","ENSANAG00000026023; ENSBTAG00000002714; ENSCANG00000034777; ENSCCAG00000031786; ENSCGRG00001015780; ENSCGRG00015010768; ENSCHIG00000023476; ENSCSAG00000011871; ENSFCAG00000007172; ENSG00000127955; ENSGGOG00000008064; ENSLAFG00000022531; ENSLCNG00005007413; ENSMMUG00000023470; ENSMNEG00000038772; ENSMPUG00000018288; ENSMUSG00000057614; ENSPCTG00005000350; ENSPTRG00000019343; ENSSSCG00000015407; ENSSSCG00070000597; ENSSSUG00005001506; ENSTSYG00000026142; ENSTTRG00000006465; ENSVVUG00000019537","Calcium regulation in cardiac cell; G protein signaling pathways; S1P receptor signal transduction; Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Chemokine signaling pathway; G protein signaling pathways; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Common pathways underlying drug addiction; Nicotine activity on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone; G protein signaling pathways; Cell-type dependent selectivity of CCK2R signaling; Chemokine signaling pathway; Purinergic signaling; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Calcium regulation in cardiac cells; Signal transduction of S1P receptor; Serotonin HTR1 group and FOS pathway; Calcium regulation in cardiac cells; G protein signaling pathways","G alpha (i) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Extra-nuclear estrogen signaling; G alpha (i) signalling events; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Adenylate cyclase inhibitory pathway; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion; Adenylate cyclase inhibitory pathway; G alpha (i) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12","Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Axon guidance; Apelin signaling pathway; Gap junction; Platelet activation; Leukocyte transendothelial migration; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Long-term depression; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Gastric acid secretion; Parkinson disease; Cocaine addiction; Morphine addiction; Alcoholism; Pertussis; Chagas disease; Toxoplasmosis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Chemical carcinogenesis",248.1,262,298.5,199.5,270.9,230.6,1.1534950071326677,0.20601175937370933,0.23312884978622903,0.6324039790419359,0.4628197455201821,0.33458812079304723,3933]
["High","P63167","Dynein light chain 1, cytoplasmic [OS=Homo sapiens]",45,3,7,2,89,10.4,7.4,14.67,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","DYNLL1","ENSG00000088986","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome","Neutrophil degranulation; MHC class II antigen presentation; COPI-mediated anterograde transport; HCMV Early Events; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria","Vasopressin-regulated water reabsorption; Salmonella infection",244.5,220,186.7,238.6,180.9,199.3,1.052359405300582,0.07362750281721171,0.6744893229988782,0.1710249207131611,0.8258448540027037,0.08310153304178076,6377]
["High","P63279","SUMO-conjugating enzyme ubc9 [OS=Homo sapiens]",6,1,9,1,158,18,8.66,16.67,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2I","ENSG00000103275","Androgen receptor signaling pathway; TGF-beta signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of RNA binding proteins; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Processing of DNA double-strand break ends; Formation of Incision Complex in GG-NER; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)","Nucleocytoplasmic transport; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; MicroRNAs in cancer",438.3,539.6,461.4,678.8,418,440,0.9365564809994795,-0.09456209305038528,0.733349783985539,0.1346888316056243,0.8633888892278481,0.06379354448920603,6632]
["High","P68133","Actin, alpha skeletal muscle [OS=Homo sapiens]",40,17,1318,3,377,42,5.39,2621.67,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTA1","ENSG00000143632","Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Malignant pleural mesothelioma","Striated Muscle Contraction","",16043.9,18314.4,17036.4,14796.9,14007.9,14323.1,1.1916810231891655,0.2529981218348086,0.01669009623760937,1.7775411591061216,0.10620723017380111,0.9738459171744905,1227]
["High","P68431","Histone H3.1 [OS=Homo sapiens]",57,8,86,1,136,15.4,11.12,147.96,"cell organization and biogenesis","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","H3C1; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8","ENSG00000197153; ENSG00000197409; ENSG00000273983; ENSG00000274750; ENSG00000275379; ENSG00000275714; ENSG00000277775; ENSG00000278828; ENSG00000286522; ENSG00000287080","Histone modifications; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma","Estrogen-dependent gene expression; Transcriptional regulation by small RNAs; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; HATs acetylate histones; Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Amyloid fiber formation; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Transcriptional regulation of granulopoiesis; B-WICH complex positively regulates rRNA expression; SIRT1 negatively regulates rRNA expression; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Late Events; HCMV Early Events; Formation of the beta-catenin:TCF transactivating complex; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Meiotic recombination; Assembly of the ORC complex at the origin of replication; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Interleukin-7 signaling; RMTs methylate histone arginines; PKMTs methylate histone lysines","Neutrophil extracellular trap formation; Alcoholism; Shigellosis; Transcriptional misregulation in cancer; Systemic lupus erythematosus",5417,4933.4,4599.3,3966,4248.3,3727.4,1.2518904343602673,0.3241083029078803,0.023433955998879204,1.6301543898726152,0.12354647430064067,0.9081696437351883,1481]
["High","P78324","tyrosine-protein phosphatase non-receptor type substrate 1 [OS=Homo sapiens]",12,4,5,4,504,54.9,6.98,7.62,"cell adhesion;stress response;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","SIRPA","ENSG00000198053","Prolactin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Male infertility","Neutrophil degranulation; Cell surface interactions at the vascular wall; Signal regulatory protein family interactions","Osteoclast differentiation",140.7,140.5,130.9,207.2,153.8,195.9,0.7399892260729036,-0.4344238290165122,0.04352267517458164,1.3612844180467318,0.1759839708768169,0.7545268871674912,1931]
["High","P78362-1","SRSF protein kinase 2 [OS=Homo sapiens]",22,15,40,11,688,77.5,4.97,74.58,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","SRPK2","ENSG00000135250","mRNA processing","Maturation of nucleoprotein","",1282.4,1189.3,1283.4,1317.1,1231.3,1294.2,0.9772289595586323,-0.03323147729881198,0.510187343222367,0.2922703196126778,0.7135129457066526,0.14659814280447192,5583]
["High","P78368","casein kinase I isoform gamma-2 [OS=Homo sapiens]",10,4,6,1,415,47.4,9.06,10.9,"cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK1G2","ENSG00000133275","Hedgehog signaling pathway","Disassembly of the destruction complex and recruitment of AXIN to the membrane; Sphingolipid de novo biosynthesis","Hedgehog signaling pathway",337.7,310,329.6,357.3,384.8,374.1,0.8755599354954311,-0.19172215474091522,0.015669121706929967,1.8049553461302534,0.10289697416964608,0.9875973960903095,1189]
["High","P78536-1","Disintegrin and metalloproteinase domain-containing protein 17 [OS=Homo sapiens]",15,11,15,11,824,93,5.76,25,"cell adhesion;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM17","ENSG00000151694; ENSPPAG00000038185","Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Notch signaling; Copper homeostasis; Ebola virus infection in host; Soluble ACE2-mediated cell entry of SARS-CoV-2; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Notch signaling pathway","Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; Release of Hh-Np from the secreting cell; Growth hormone receptor signaling; Nuclear signaling by ERBB4; TNF signaling; CD163 mediating an anti-inflammatory response; Regulated proteolysis of p75NTR","Notch signaling pathway; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Coronavirus disease",515.8,547,524.1,510.4,533.3,502,1.0266545901533288,0.03795087991164236,0.35724994834422324,0.44702782533285057,0.590600803868663,0.2287059662509151,4723]
["High","P78563-1","Double-stranded RNA-specific editase 1 [OS=Homo sapiens]",1,1,2,1,741,80.7,9.01,3.57,"cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ADARB1","ENSG00000197381","","C6 deamination of adenosine; Formation of editosomes by ADAR proteins","",71.1,73.5,75.4,74.2,63,67.1,1.0768477728830153,0.1068143196787947,0.20919039506204232,0.6794582598970982,0.4323341992176883,0.3641804088242776,3778]
["High","P81605","Dermcidin [OS=Homo sapiens]",16,2,3,2,110,11.3,6.54,2.57,"protein metabolism;stress response;other biological processes","non-structural extracellular","other molecular function","DCD","ENSG00000161634","","Antimicrobial peptides","",58.1,60.5,52,49.6,51.9,62.3,1.0415140415140416,0.05868228967728166,0.6517516258614959,0.18591787676600818,0.8122708211854047,0.09029914743754154,6265]
["High","P82912-1","28S ribosomal protein S11, mitochondrial [OS=Homo sapiens]",29,3,6,3,194,20.6,10.81,19.37,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS11","ENSG00000181991","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",300.3,291.9,276.4,290.9,300.4,291.8,0.9835805684520442,-0.02388486145274446,0.5606876938128023,0.25127897585771114,0.7520785970263459,0.12373677048395633,5821]
["Medium","P83369","U7 snRNA-associated Sm-like protein LSm11 [OS=Homo sapiens]",3,1,1,1,360,39.5,10.99,2.63,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","LSM11","ENSG00000155858","","RNA Polymerase II Transcription Termination; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","",26.9,26.4,19,27.7,24.4,27,0.9140328697850822,-0.12968204752167392,0.4552438647315434,0.34175589842967125,0.6710485361192922,0.17324606670663356,5297]
["High","P84022","Mothers against decapentaplegic homolog 3 [OS=Homo sapiens]",10,4,8,1,425,48.1,7.15,23.23,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","SMAD3","ENSG00000166949","Androgen receptor signaling pathway; Cell cycle; AGE/RAGE pathway; Adipogenesis; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Ovarian infertility; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularisation processes; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; TGF-beta receptor signaling; DNA damage response (only ATM dependent)","Ub-specific processing proteases; Interleukin-37 signaling; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX3 regulates BCL2L11 (BIM) transcription; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates CDKN1A transcription; NOTCH4 Intracellular Domain Regulates Transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer","FoxO signaling pathway; Cell cycle; Endocytosis; Cellular senescence; Wnt signaling pathway; TGF-beta signaling pathway; Apelin signaling pathway; Hippo signaling pathway; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Th17 cell differentiation; AGE-RAGE signaling pathway in diabetic complications; Hepatitis B; Human T-cell leukemia virus 1 infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer; Chronic myeloid leukemia; Hepatocellular carcinoma; Gastric cancer; Inflammatory bowel disease; Diabetic cardiomyopathy",187.1,181.9,195.8,232.6,217.6,240.5,0.817721152454032,-0.2903191350404574,0.005887388322990149,2.2300773178535582,0.06153778852196397,1.2108581150103215,747]
["High","P84103","Serine/arginine-rich splicing factor 3 [OS=Homo sapiens]",43,9,79,8,164,19.3,11.65,141.64,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SRSF3","ENSG00000112081","mRNA processing","mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection",3258.8,3512.3,3050.3,3026.4,2950.1,3123.2,1.0793103069331957,0.11010970626492174,0.16701736763584804,0.7772383655217031,0.37810136459863775,0.42239175523045847,3449]
["High","P86397","Hydroxyacyl-thioester dehydratase type 2, mitochondrial [OS=Homo sapiens]",17,1,2,1,168,18.5,8.92,5.04,"other metabolic processes","mitochondrion;nucleus","other molecular function","HTD2","ENSG00000255154","Mitochondrial fatty acid synthesis pathway","Fatty acyl-CoA biosynthesis","Fatty acid biosynthesis; Metabolic pathways; Fatty acid metabolism",29.5,28.6,28.5,29.7,28.1,31.8,0.9665178571428571,-0.04913170733087927,0.4214591602886112,0.3752445024641717,0.6449927721547386,0.19044515207930748,5102]
["High","P98171-1","Rho GTPase-activating protein 4 [OS=Homo sapiens]",7,5,7,5,946,105,6.34,7.93,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","ARHGAP4","ENSG00000089820","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle","",374,383.3,387.7,432.1,412.3,407.8,0.9143906724165468,-0.12911740800932267,0.01357860307645113,1.8671449065941257,0.09577392305413769,1.018752722814213,1107]
["High","P98198-1","Phospholipid-transporting ATPase ID [OS=Homo sapiens]",4,3,6,3,1209,137.4,7.01,5.74,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi","transporter activity;other molecular function","ATP8B2","ENSG00000143515; ENSPPAG00000034141; ENSPTRG00000001382","Mesodermal commitment pathway; Complement system in neuronal development and plasticity","Ion transport by P-type ATPases","",173.5,152.4,171.5,162.2,171.7,174.8,0.9777865146451739,-0.03240858664572238,0.6511303403665205,0.1863320675977181,0.8117556598406183,0.09057467464039048,6263]
["High","Q00341-1","Vigilin [OS=Homo sapiens]",48,53,183,52,1268,141.4,6.87,403.1,"other metabolic processes;transport","non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","HDLBP","ENSG00000115677","","HDL clearance","",7042.9,6585.3,6952.5,6906.4,7166.8,6984.7,0.9773386709975829,-0.0330695180536116,0.3758086664035049,0.42503320899381614,0.6061380019166631,0.21742848697607045,4841]
["High","Q00688","peptidyl-prolyl cis-trans isomerase FKBP3 [OS=Homo sapiens]",54,10,29,10,224,25.2,9.28,56.54,"protein metabolism;other metabolic processes","nucleus","other molecular function","FKBP3","ENSG00000100442","","","",1310.2,1323.9,1262.5,1648.9,1416.5,1349.8,0.882542127196956,-0.18026294936750267,0.13514644540608614,0.8691953725388673,0.3359514313055462,0.4737235042787366,3141]
["High","Q01081","Splicing factor U2AF 35 kDa subunit [OS=Homo sapiens]",47,8,66,8,240,27.9,8.81,83.97,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","U2AF1","ENSG00000160201","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","Spliceosome; Shigellosis",2254.1,2279.4,2218.6,2320.7,2166.2,2260.8,1.0006520740400435,9.4043739976790511E-4,0.9772334012317238,0.010001697528808586,0.9869665498405509,0.005697566140740375,7731]
["High","Q01082-1","Spectrin beta chain, non-erythrocytic 1 [OS=Homo sapiens]",69,146,748,14,2364,274.4,5.57,1717.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SPTBN1","ENSG00000115306; ENSPPAG00000020369; ENSPTRG00000011924","TGF-beta signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways","RHOV GTPase cycle; RHOU GTPase cycle; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Signaling by FLT3 fusion proteins; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Nephrin family interactions; Interaction between L1 and Ankyrins","",30628.7,30232.9,30317.2,30518,30612.4,30555.3,0.994471329771164,-0.007998315576144143,0.2429518142897923,0.6144798534105929,0.47364987914474366,0.3245425691722139,4005]
["High","Q01518-1","adenylyl cyclase-associated protein 1 [OS=Homo sapiens]",52,23,219,1,475,51.9,8.06,510.69,"cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CAP1","ENSG00000131236","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity","Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling","",195.3,218.1,192.5,196.5,199.9,201.9,1.0127026575296676,0.018210642571986648,0.774345171332522,0.11106540548108129,0.8854843435507223,0.05281911326514191,6828]
["High","Q01780","exosome component 10 [OS=Homo sapiens]",34,27,72,27,885,100.8,8.46,142.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","EXOSC10","ENSG00000171824","","Major pathway of rRNA processing in the nucleolus and cytosol","RNA degradation",2852,2788.1,2839.4,3218.3,3295.4,3227.2,0.8705047788192055,-0.200075877011164,1.7593864128916895E-4,3.754638766252328,0.012959706709300294,1.8874048268584633,106]
["High","Q01844","RNA-binding protein EWS [OS=Homo sapiens]",7,4,36,4,656,68.4,9.33,89.93,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","EWSR1","ENSG00000182944","VEGFA-VEGFR2 signaling pathway","","Transcriptional misregulation in cancer",1266.4,1282.4,1261.6,1561.1,1298.1,1445.3,0.885213149030085,-0.17590321367658499,0.09723079117458448,1.0121961803454402,0.2784952375242684,0.5551822271854595,2726]
["High","Q01970-1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [OS=Homo sapiens]",34,32,82,32,1234,138.7,5.9,165.67,"other metabolic processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","other molecular function","PLCB3","ENSG00000149782","Alzheimer's disease and miRNA effects; S1P receptor signal transduction; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; GPR40 pathway; MAPK cascade; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; Calcium regulation in cardiac cells","G alpha (q) signalling events; Synthesis of IP3 and IP4 in the cytosol; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Inositol phosphate metabolism; Metabolic pathways; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Apelin signaling pathway; Gap junction; Platelet activation; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Pathways in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis",3168.1,3421.3,3023.5,3190.4,2968.5,3310.1,1.015196958496145,0.02175965202106807,0.7701281205610018,0.11343701843268066,0.8833789283590865,0.05385296437864368,6807]
["High","Q02127","Dihydroorotate dehydrogenase (Quinone), mitochondrial [OS=Homo sapiens]",17,5,9,5,395,42.8,9.67,20.63,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","DHODH","ENSG00000102967","Pyrimidine metabolism","Pyrimidine biosynthesis","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",276.5,350.9,300.5,315.7,282.7,325.3,1.0045469308216952,0.006544966044447128,0.9587488191749178,0.018295157933323078,0.9779112710800468,0.00970054830896751,7655]
["High","Q02318","Sterol 26-hydroxylase, mitochondrial [OS=Homo sapiens]",10,5,7,5,531,60.2,8.9,11.54,"other metabolic processes","other membranes;mitochondrion","other molecular function","CYP27A1","ENSG00000135929","Vitamin D metabolism; PPAR signaling pathway; Oxidation by cytochrome P450; Vitamin D-sensitive calcium signaling in depression; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Metapathway biotransformation Phase I and II","Endogenous sterols; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol; Defective CYP27A1 causes CTX","Primary bile acid biosynthesis; Metabolic pathways; PPAR signaling pathway; Cholesterol metabolism",322.3,313.5,310.2,415.5,473,409,0.7290944123314065,-0.4558224499058481,0.004764417469446114,2.321990191619695,0.054546292670726186,1.2632347616175386,682]
["High","Q02880","DNA topoisomerase 2-beta [OS=Homo sapiens]",39,55,218,39,1626,183.2,8,460.98,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP2B","ENSG00000077097","","SUMOylation of DNA replication proteins","Platinum drug resistance",5166.3,5186.6,5444.5,5935.7,6314.1,6231.4,0.8547821570027923,-0.22637130185484403,0.003561563322009056,2.448359329810316,0.048028819375210204,1.3184980888791167,579]
["High","Q03013-1","glutathione S-transferase mu 4 [OS=Homo sapiens]",46,9,31,2,218,25.5,5.9,59.38,"other metabolic processes","non-structural extracellular;cytosol;other cell component","other molecular function","GSTM4","ENSG00000168765","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II","Glutathione conjugation; Biosynthesis of maresin conjugates in tissue regeneration (MCTR)","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",56.2,66.8,57.4,64.7,60.9,64.6,0.9484752891692955,-0.0763179076051825,0.4127729136701013,0.38428880902997925,0.6382041405814161,0.19504038249000522,5050]
["High","Q03135","Caveolin-1 [OS=Homo sapiens]",27,4,6,4,178,20.5,6.02,10.73,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","CAV1","ENSG00000105974","Androgen receptor signaling pathway; Integrin-mediated cell adhesion; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host; Acute viral myocarditis; EGF/EGFR signaling pathway; Congenital generalized lipodystrophy (CGL)","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RND1 GTPase cycle; RHOH GTPase cycle; Basigin interactions; Triglyceride catabolism; RHOD GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; NOSTRIN mediated eNOS trafficking; RND3 GTPase cycle; Disassembly of the destruction complex and recruitment of AXIN to the membrane; FOXO-mediated transcription of cell cycle genes; VEGFR2 mediated vascular permeability; eNOS activation","Endocytosis; Focal adhesion; Prion disease; Bacterial invasion of epithelial cells; Proteoglycans in cancer; Viral myocarditis; Fluid shear stress and atherosclerosis",382,435.5,383.6,431,405,409.1,0.9646614729740582,-0.05190534623376546,0.49040857631448376,0.3094419434376702,0.6993808518472127,0.1552862622911907,5475]
["High","Q03426","mevalonate kinase [OS=Homo sapiens]",15,4,12,4,396,42.4,6.46,11.91,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","MVK","ENSG00000110921","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Terpenoid backbone biosynthesis; Metabolic pathways; Peroxisome",241.9,275.2,299.5,292.5,291.9,287,0.9371126922194171,-0.09370554569001685,0.3376756944664355,0.4715001982896514,0.5700695832203089,0.24407213070606742,4625]
["High","Q04726","Transducin-like enhancer protein 3 [OS=Homo sapiens]",20,13,23,10,772,83.4,7.2,57.7,"cell-cell signaling;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","TLE3","ENSG00000140332","White fat cell differentiation","Estrogen-dependent gene expression; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes","Wnt signaling pathway; Notch signaling pathway",874.1,844.5,911.4,895.4,944,917.8,0.9538662411141738,-0.06814112091104688,0.15089795981848703,0.8213166319643895,0.3585548600921323,0.44544438640479705,3286]
["High","Q04727-1","Transducin-like enhancer protein 4 [OS=Homo sapiens]",16,10,20,2,773,83.7,7.5,44.85,"cell-cell signaling;signal transduction;other biological processes","nucleus;other cell component","other molecular function","TLE4","ENSG00000106829","","Formation of the beta-catenin:TCF transactivating complex; NOTCH1 Intracellular Domain Regulates Transcription; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes","Wnt signaling pathway; Notch signaling pathway",126.4,141.4,128.7,162.4,138.8,155.2,0.868755477651183,-0.20297792569734116,0.07618155959496689,1.1181501406727758,0.2407226294283697,0.6184830814162198,2471]
["High","Q05086","Ubiquitin-protein ligase E3A [OS=Homo sapiens]",27,22,39,22,875,100.6,5.22,96.32,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE3A","ENSG00000114062","Androgen receptor signaling pathway; MECP2 and associated Rett syndrome; Prader-Willi and Angelman syndrome; Synaptic signaling pathways associated with autism spectrum disorder","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis; Human papillomavirus infection; Viral carcinogenesis",1398.8,1361.4,1463.8,1375.7,1394.9,1382.5,1.0170715850810237,0.02442122472821986,0.48086293576591366,0.31797869643977705,0.6917055641968043,0.16007873076884116,5428]
["High","Q05519","serine/arginine-rich splicing factor 11 [OS=Homo sapiens]",28,15,76,15,484,53.5,10.52,131.75,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","SRSF11","ENSG00000116754","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",4927,4419,4431.3,4439.4,4453.4,4532.7,1.0262038657778108,0.03731736537980718,0.527846422731188,0.2774924173569622,0.7273958469264236,0.13822918288274513,5666]
["High","Q05932-1","Folylpolyglutamate synthase, mitochondrial [OS=Homo sapiens]",13,5,5,5,587,64.6,7.94,9.7,"cell cycle OR cell proliferation;other metabolic processes;developmental processes","other membranes;cytosol;mitochondrion;other cell component","other molecular function","FPGS","ENSG00000136877","Fluoropyrimidine activity","","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance",110.2,115.5,129.4,93.2,81.9,90.4,1.3374764595103579,0.41951349932945575,0.010935996731959852,1.961141628221874,0.08471057786026044,1.072062355672745,1008]
["High","Q06203","amidophosphoribosyltransferase [OS=Homo sapiens]",43,16,53,16,517,57.4,6.76,119.08,"cell cycle OR cell proliferation;other metabolic processes;transport;developmental processes;other biological processes","cytosol","other molecular function","PPAT","ENSG00000128059","Fluoropyrimidine activity; Metabolic reprogramming in colon cancer","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Alanine, aspartate and glutamate metabolism; Metabolic pathways",1711,1852.3,1907.7,1677.8,1750.9,1759,1.0546099427491953,0.07670950346829136,0.214106104666826,0.6693709497755302,0.43854681669427525,0.35798403708318366,3812]
["High","Q06546","GA-binding protein alpha chain [OS=Homo sapiens]",27,8,23,8,454,51.3,4.97,65,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GABPA","ENSG00000154727","Energy metabolism; Allograft rejection; Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression; Malignant pleural mesothelioma","Transcriptional activation of mitochondrial biogenesis","",727.1,726.7,633.7,780,731.6,743.2,0.9258027319496186,-0.11122327500507243,0.17952892197128906,0.7458655769423388,0.392430521487073,0.4062372225002122,3572]
["High","Q06787","synaptic functional regulator FMR1 [OS=Homo sapiens]",16,10,25,2,632,71.1,7.42,45.38,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","FMR1","ENSG00000102081","Serotonin and anxiety; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome","","",850.5,784.7,831.4,889,881.5,868.1,0.9348139164708558,-0.0972488833660615,0.04882097627857595,1.311393540196196,0.18667687697508373,0.7289094732884522,2042]
["High","Q07065","Cytoskeleton-associated protein 4 [OS=Homo sapiens]",67,40,173,40,602,66,5.92,454.28,"","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","","CKAP4","ENSG00000136026","","Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RND2 GTPase cycle; RND3 GTPase cycle; Surfactant metabolism","Protein processing in endoplasmic reticulum",8307.1,8443.3,8124.9,8886.8,8626.8,8541.2,0.9547300305509928,-0.06683525561050539,0.04735952505423263,1.324592661592574,0.18424672228373112,0.7346002294214243,2007]
["High","Q07820","Induced myeloid leukemia cell differentiation protein Mcl-1 [OS=Homo sapiens]",49,10,31,10,350,37.3,5.66,88.8,"stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","transporter activity;other molecular function","MCL1","ENSG00000143384","Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-Akt signaling pathway; MicroRNA network associated with chronic lymphocytic leukemia; Host-pathogen interaction of human coronaviruses - apoptosis; Malignant pleural mesothelioma","Interleukin-4 and Interleukin-13 signaling","PI3K-Akt signaling pathway; Apoptosis; JAK-STAT signaling pathway; MicroRNAs in cancer",934.7,949.6,964.1,829.5,792,816.9,1.1681430446194225,0.2242169498404268,6.0133953702613254E-4,3.2208802411107693,0.021737310671759456,1.662794187603065,216]
["High","Q07954","prolow-density lipoprotein receptor-related protein 1 [OS=Homo sapiens]",19,65,111,65,4544,504.3,5.39,219.85,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","LRP1","ENSG00000123384","Alzheimer's disease and miRNA effects; Regulation of Wnt / B-catenin signaling by small molecule compounds; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Alzheimer's disease","Retinoid metabolism and transport; Scavenging of heme from plasma","Cholesterol metabolism; Alzheimer disease; Malaria",3553.1,3592.3,3563.7,3980.1,3983.7,4102.8,0.8874993784496047,-0.17218198575787688,4.2003223252885883E-4,3.3767173813347164,0.01822006484214072,1.7394500817793872,180]
["High","Q08345-1","Epithelial discoidin domain-containing receptor 1 [OS=Homo sapiens]",1,1,1,1,913,101.1,6.83,3.57,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","DDR1","ENSG00000137332; ENSG00000204580; ENSG00000215522; ENSG00000230456; ENSG00000234078; ENSPPAG00000026163; ENSPTRG00000017942","Interactions between LOXL4 and oxidative stress pathway","Non-integrin membrane-ECM interactions","",68,71.2,39.2,99.3,65.5,79.6,0.729950900163666,-0.454128669898425,0.19442826472927782,0.7112405998846996,0.4124139883200764,0.38466661267273083,3681]
["High","Q08623","Pseudouridine-5'-phosphatase [OS=Homo sapiens]",12,2,7,2,228,25.2,5.31,11.08,"other metabolic processes","cytosol","other molecular function","PUDP","ENSG00000130021","","Pyrimidine salvage","",159.4,175.7,160.3,156.9,154.9,165.3,1.0383567386292183,0.054302182262058254,0.3791561486452866,0.4211818968155773,0.6087705549295491,0.21554636172511926,4863]
["High","Q08AD1","Calmodulin-regulated spectrin-associated protein 2 [OS=Homo sapiens]",15,15,19,15,1489,168,6.8,35.55,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi","cytoskeletal activity;other molecular function","CAMSAP2","ENSG00000118200","","","",528.4,501.3,492.2,546.3,501.6,495.8,0.9858780851201657,-0.020518842672853834,0.725750348135429,0.13921274716937235,0.8584545854024284,0.06628267526232216,6601]
["High","Q09028","Histone-binding protein RBBP4 [OS=Homo sapiens]",38,15,119,8,425,47.6,4.89,322.27,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBBP4","ENSG00000162521","Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Malignant pleural mesothelioma","RNA Polymerase I Transcription Initiation; HCMV Early Events; Transcriptional Regulation by E2F6; G1/S-Specific Transcription; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1","Cellular senescence",2358.5,2400.5,2332.5,2451.7,2466.7,2544.6,0.9502210907141901,-0.07366486632099802,0.02394669356148364,1.6207544432988314,0.12531888963006987,0.901983461776846,1492]
["Medium","Q09328","Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A [OS=Homo sapiens]",1,1,1,1,741,84.5,8.12,2.01,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","MGAT5","ENSG00000152127","","N-Glycan antennae elongation; Maturation of spike protein","N-Glycan biosynthesis; Metabolic pathways",62.7,64.5,62.2,53.9,60.8,56.3,1.1076023391812866,0.14744000569512486,0.04562405784889839,1.3408060907601105,0.18046233216018168,0.743613434435093,1974]
["High","Q0VG06","Fanconi anemia core complex-associated protein 100 [OS=Homo sapiens]",8,4,5,4,881,93.4,5.29,13.18,"DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","nucleic acid binding activity","FAAP100","ENSG00000185504","DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",154.5,165.3,147.9,151.4,132.7,140.6,1.1012479397221566,0.13913932007153873,0.1256636985719404,0.9007901621455745,0.322121522800299,0.49198025648696286,3046]
["High","Q10589","bone marrow stromal antigen 2 [OS=Homo sapiens]",22,4,16,4,180,19.8,5.6,37.57,"stress response;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","BST2","ENSG00000130303","Ebola virus infection in host; Host-pathogen interaction of human coronaviruses - MAPK signaling","Neutrophil degranulation; Interferon alpha/beta signaling","Herpes simplex virus 1 infection; Human immunodeficiency virus 1 infection",538.5,590.7,577.1,853.7,835.5,819.3,0.6802072951963326,-0.5559536159113921,1.3388097021049285E-4,3.8732811490515133,0.01161491794892809,1.9349838538322028,90]
["High","Q12767","Transmembrane protein 94 [OS=Homo sapiens]",2,2,2,2,1356,151.1,6.44,7.02,"","other membranes","","TMEM94","ENSG00000177728","","","",46,52.9,46.2,48.9,50,43.9,1.016106442577031,0.023051540037644983,0.8073696415682287,0.09292758480838204,0.9050886089540171,0.043308900909728935,6965]
["High","Q12797","Aspartyl/Asparaginyl beta-hydroxylase [OS=Homo sapiens]",32,18,71,18,758,85.8,5.01,161.12,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","ASPH","ENSG00000198363","","Stimuli-sensing channels; Ion homeostasis","Calcium signaling pathway; Cardiac muscle contraction",2464.9,2557,2566.7,2415.3,2360.7,2398.9,1.0576593401998635,0.08087502693786151,0.019030496927377648,1.720549871197986,0.11386216092640972,0.9436205782136504,1305]
["High","Q12824-1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [OS=Homo sapiens]",43,14,64,14,385,44.1,6.23,125.24,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101347788; LOC111142756; Smarcb1; SMARCB1","ENSCAFG00000014105; ENSCATG00000029590; ENSCCAG00000036123; ENSCHIG00000019816; ENSCSAG00000011285; ENSDLEG00000015913; ENSECAG00000007797; ENSG00000099956; ENSG00000275837; ENSHGLG00000019077; ENSMFAG00000040790; ENSMLUG00000004975; ENSMMUG00000009098; ENSMNEG00000033936; ENSMUSG00000000902; ENSPANG00000026464; ENSPPAG00000028391; ENSRBIG00000027964; ENSRFEG00010017090; ENSRROG00000030710; ENSSBOG00000031674; ENSSSCG00000010070; ENSSSCG00070020965; ENSSSUG00005014167; ENSSTOG00000012408; ENSTSYG00000008262; ENSUAMG00000010813","TNF-alpha NF-kB signaling pathway; Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation","RMTs methylate histone arginines; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",1519.7,1514.9,1502.1,1584.6,1512.9,1572.4,0.9714769052870513,-0.04174839555011046,0.12287958998915291,0.9105202464153097,0.31885803876214885,0.49640262949675484,3009]
["High","Q12851","Mitogen-activated protein kinase kinase kinase kinase 2 [OS=Homo sapiens]",8,5,7,5,820,91.5,6.34,12.27,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","kinase activity;other molecular function","MAP4K2","ENSG00000168067","TNF-alpha signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma","","MAPK signaling pathway",104.7,104.5,86.8,105.5,116.1,107.3,0.8999695956217696,-0.15205183231909009,0.18094276644519683,0.742458774013248,0.3941967411841788,0.40428697034470024,3584]
["High","Q12887","Protoheme IX farnesyltransferase, mitochondrial [OS=Homo sapiens]",4,1,1,1,443,48.9,9.19,2.28,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","COX10","ENSG00000006695","Mitochondrial complex IV assembly","Heme biosynthesis","Oxidative phosphorylation; Porphyrin metabolism; Metabolic pathways; Biosynthesis of cofactors; Thermogenesis",26.3,22.1,23.9,18,19.1,20.7,1.2508650519031146,0.32292615445043943,0.028842820972961862,1.5399622656905803,0.13910114030690934,0.8566693097853185,1619]
["High","Q12906-7","Isoform 7 of Interleukin enhancer-binding factor 3 [OS=Homo sapiens]",68,50,542,3,898,95.7,8.81,1315.87,"","","","ILF3","","","","",23320.8,23752.7,22649.2,24101.6,23152.1,23981,0.9787743894478393,-0.030951742448385024,0.3142925482331324,0.5026659158312778,0.5478893093557262,0.26130717361733036,4479]
["High","Q12959","Disks large homolog 1 [OS=Homo sapiens]",24,18,28,16,904,100.4,5.76,72.85,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","DLG1","ENSG00000075711","Brain-derived neurotrophic factor (BDNF) signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Disruption of postsynaptic signaling by CNV; 3q29 copy number variation syndrome","Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; NrCAM interactions; Activation of Ca-permeable Kainate Receptor","Hippo signaling pathway; Tight junction; T cell receptor signaling pathway; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Viral carcinogenesis",1307.6,1375.7,1356.3,1442.2,1413.4,1433.8,0.9417634167948897,-0.08656341327102925,0.019317746842868348,1.7140435296168692,0.11531572427302453,0.9381114689464822,1308]
["High","Q12974","Protein tyrosine phosphatase type IVA 2 [OS=Homo sapiens]",19,3,6,2,167,19.1,8.37,8.28,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PTP4A2","ENSG00000184007","","RAB geranylgeranylation","",230,205.2,263.6,219.8,234.3,230.5,1.0207420391469468,0.029618315906921273,0.7998456872531714,0.0969937925565176,0.8991066982540689,0.046188766872625714,6946]
["High","Q12999","Tetraspanin-31 [OS=Homo sapiens]",3,1,2,1,210,23,7.97,5.24,"other biological processes","plasma membrane;other membranes","","TSPAN31","ENSG00000135452","","","",105.6,131.9,117.7,104.1,108,123.8,1.0574575766597203,0.08059978611560766,0.5433464034569939,0.2649232032954986,0.7396179773696319,0.13099254129660692,5736]
["High","Q13045-1","protein flightless-1 homolog [OS=Homo sapiens]",36,36,80,36,1269,144.7,6.05,191.17,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLII","ENSG00000177731; ENSG00000284571","VEGFA-VEGFR2 signaling pathway","","",3709.3,3571.7,3775.3,3680,3707.7,3631,1.0034123807708712,4.9146442578444135E-3,0.8543508485874566,0.0683637448675603,0.9294651561614687,0.03176688644124091,7177]
["High","Q13111-1","Chromatin assembly factor 1 subunit A [OS=Homo sapiens]",25,17,31,17,956,106.9,5.94,52.65,"","","","","","","","",1251.8,1256.5,1194.6,1497.2,1402.2,1501.9,0.8413196101151932,-0.24927412278606623,3.6274027190441893E-3,2.4404042257954828,0.04825001776881947,1.3165025223844617,587]
["High","Q13123","Protein Red [OS=Homo sapiens]",31,14,58,14,557,65.6,6.64,127.66,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","IK","ENSG00000113141","","","",2747.1,3003.7,3069.4,3251.5,3080.8,2900.9,0.9552701122037861,-0.06601936756370895,0.38453159311541646,0.41506797276234453,0.6133652051164804,0.21228086424286577,4895]
["High","Q13136","Liprin-alpha-1 [OS=Homo sapiens]",23,27,39,22,1202,135.7,6.29,100.62,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;other cell component","","PPFIA1","ENSG00000131626","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",2093.9,2005.1,1893.1,2109.1,1934.8,2052.2,0.9829399124030119,-0.02482486827855823,0.6778563933022033,0.16886230348156261,0.8275019885715452,0.0822309538971243,6396]
["High","Q13158","FAS-associated death domain protein [OS=Homo sapiens]",48,7,28,7,208,23.3,5.69,60.07,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","FADD","ENSG00000168040","TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor (RLR) pathway; VEGFA-VEGFR2 signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Alzheimer's disease; Toll-like receptor signaling pathway","Regulation of TNFR1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL  signaling; TLR3-mediated TICAM1-dependent programmed cell death; TNFR1-induced proapoptotic signaling; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis","Platinum drug resistance; Apoptosis; Apoptosis; Necroptosis; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Alcoholic liver disease; Alzheimer disease; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Salmonella infection; Chagas disease; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",778.7,745.4,802.4,874.7,886.1,856.1,0.8890290037831021,-0.16969760841782258,0.006624416493609524,2.1788523701860343,0.06506093582654486,1.186679694183869,795]
["High","Q13206","probable ATP-dependent RNA helicase DDX10 [OS=Homo sapiens]",22,18,36,18,875,100.8,8.63,70.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX10","ENSG00000178105","","","",1589.2,1704.2,1637.5,1569.5,1632.9,1658.6,1.0143797572515942,0.020597860759385533,0.6132857442111097,0.21233713034333504,0.78603662028896,0.10455722034870461,6092]
["High","Q13257-1","Mitotic spindle assembly checkpoint protein MAD2A [OS=Homo sapiens]",35,8,25,8,205,23.5,5.08,53.29,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD2L1","ENSANAG00000022503; ENSCANG00000042550; ENSCATG00000040684; ENSCCAG00000030445; ENSG00000164109; ENSGGOG00000002516; ENSMLEG00000036707; ENSMMUG00000054168; ENSMNEG00000040691; ENSPANG00000019721; ENSPPAG00000028274; ENSPTRG00000016401; ENSRBIG00000035049; ENSRROG00000029952; ENSSBOG00000031396","Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; Cell cycle","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection",1271.7,1237,1532.1,1371.3,1604.7,1469.5,0.9089641210212573,-0.1377047459534407,0.30625616212735973,0.5139151641752137,0.5396633071294121,0.2678771095481901,4431]
["High","Q13283","Ras GTPase-activating protein-binding protein 1 [OS=Homo sapiens]",45,15,98,14,466,52.1,5.52,224.81,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","G3BP1","ENSG00000145907","","","",4653.8,4777.2,4444.1,4686.6,4104.8,4375.9,1.0537543763717694,0.07553862287007439,0.291162192471277,0.5358650190124983,0.5241859347050336,0.28051463650262487,4337]
["High","Q13362","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [OS=Homo sapiens]",13,7,13,4,524,61,6.87,26.83,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","PPP2R5C","ENSG00000078304","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)","Platelet sensitization by LDL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF activation; Negative regulation of MAPK pathway; CTLA4 inhibitory signaling","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; Dopaminergic synapse; Human papillomavirus infection",378.5,426.6,402.4,413,424.2,421.6,0.9592469018112486,-0.060025894687926226,0.2975752522233688,0.5264031896239345,0.5296256141691505,0.2760310193702442,4387]
["High","Q13367","AP-3 complex subunit beta-2 [OS=Homo sapiens]",23,20,42,15,1082,119,5.59,85.06,"transport","other membranes;ER/Golgi;other cell component","","AP3B2","ENSG00000103723","","","Lysosome",1070.4,1191.6,1222.4,942.7,991.9,977.3,1.1966070263401904,0.2589494394713654,0.017190404651514283,1.7647139001685992,0.1080697902729658,0.9662956913505252,1242]
["High","Q13418","Integrin-linked protein kinase [OS=Homo sapiens]",24,12,25,12,452,51.4,8.07,41.21,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ILK","ENSG00000166333","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; PPAR signaling pathway; Eukaryotic transcription initiation; Endometrial cancer; Acute viral myocarditis; Genes controlling nephrogenesis; Development of ureteric collection system","Localization of the PINCH-ILK-PARVIN complex to focal adhesions","PPAR signaling pathway; Axon guidance; Focal adhesion; Bacterial invasion of epithelial cells; Shigellosis; Endometrial cancer",1189.7,1195.1,1229.3,1250.4,1184.9,1204,0.9930755914598961,-0.010024557119966197,0.7341404812433596,0.13422082783443068,0.8634084768109883,0.06378369182271569,6639]
["High","Q13435","Splicing factor 3b subunit 2 [OS=Homo sapiens]",49,43,282,43,895,100.2,5.67,582.83,"RNA metabolism OR transcription;other metabolic processes","nucleus","","SF3B2","ENSG00000087365","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",10862.5,10752.7,10702,12136,11089.1,11247.6,0.937472260658434,-0.0931520923942401,0.09447672247595759,1.0246751813904735,0.27351659217362884,0.5630163231847293,2697]
["High","Q13438-1","Protein os-9 [OS=Homo sapiens]",35,22,48,22,667,75.5,4.87,78.4,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;ER/Golgi","other molecular function","OS9","ENSG00000135506","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",1434.3,1373.6,1458.4,1343.4,1285,1272,1.0938108911906468,0.12936333234935718,0.0218327528696757,1.6608915010873264,0.12013399182975888,0.920334091886165,1419]
["High","Q13464","Rho-associated protein kinase 1 [OS=Homo sapiens]",27,35,47,31,1354,158.1,5.9,89.19,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function","ROCK1","ENSG00000067900","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; G13 signaling pathway","Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse; EPHB-mediated forward signaling; RND3 GTPase cycle; RHOBTB1 GTPase cycle; Potential therapeutics for SARS; VEGFA-VEGFR2 Pathway; Apoptotic cleavage of cellular proteins; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; RHOH GTPase cycle","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; TGF-beta signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer",2353.1,2012.8,2084.8,2247.5,2174.3,2067.3,0.9940823843059899,-0.008562675187821925,0.9174581444268854,0.03741373967432268,0.9571770699739607,0.01900771384365958,7484]
["High","Q13492-1","Phosphatidylinositol-binding clathrin assembly protein [OS=Homo sapiens]",18,10,25,9,652,70.7,7.9,40.14,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PICALM","ENSG00000073921","","Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; RND3 GTPase cycle","",934.6,857.5,978,862,890.6,867.9,1.057088341919481,0.08009594921199555,0.2414642641815894,0.6171471341345269,0.4720463131521908,0.3260153900105752,3994]
["High","Q13501-1","sequestosome-1 [OS=Homo sapiens]",58,14,59,14,440,47.7,5.22,141.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","SQSTM1","ENSG00000161011","IL-1 signaling pathway; RANKL/RANK signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Interleukin-1 induced activation of NF-kB; Clear cell renal cell carcinoma pathways; CAMKK2 pathway; 7q11.23 copy number variation syndrome","Interleukin-1 signaling; Signaling by ALK fusions and activated point mutants; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; PINK1-PRKN Mediated Mitophagy; NRIF signals cell death from the nucleus; Pexophagy","Mitophagy; Autophagy; Necroptosis; Cellular senescence; Osteoclast differentiation; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Shigellosis; Fluid shear stress and atherosclerosis",1630.7,1697.5,1541.1,1414.1,1411,1386.8,1.1560815783850518,0.20924320456782403,0.008963857635067792,2.047505049592962,0.07566464909687494,1.121106977673359,925]
["High","Q13555-8","Isoform 8 of Calcium/calmodulin-dependent protein kinase type II subunit gamma [OS=Homo sapiens]",22,9,21,7,556,62.1,7.42,36.99,"protein metabolism;other metabolic processes;other biological processes","other cell component","kinase activity;other molecular function","CAMK2G; LOC111145432","ENSCATG00000041481; ENSECAG00000000031; ENSFCAG00000018407; ENSG00000148660; ENSLCNG00005022562; ENSMPUG00000003376; ENSPANG00000022457; ENSPTRG00000002643","Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway; Calcium regulation in cardiac cells","","ErbB signaling pathway; Calcium signaling pathway; cAMP signaling pathway; HIF-1 signaling pathway; Oocyte meiosis; Necroptosis; Adrenergic signaling in cardiomyocytes; Wnt signaling pathway; Axon guidance; Circadian entrainment; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Dopaminergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Melanogenesis; Oxytocin signaling pathway; Glucagon signaling pathway; Aldosterone synthesis and secretion; Cushing syndrome; Gastric acid secretion; Parkinson disease; Pathways of neurodegeneration; Amphetamine addiction; Tuberculosis; Pathways in cancer; Proteoglycans in cancer; Glioma; Diabetic cardiomyopathy; Lipid and atherosclerosis",860.8,844.1,861.3,761.5,799.2,791.3,1.0910714285714285,0.12574555287376296,0.005055918210082546,2.2961999602789023,0.055995190616063145,1.2518492726116657,705]
["High","Q13573","SNW domain-containing protein 1 [OS=Homo sapiens]",19,10,17,10,536,61.5,9.52,28.8,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SNW1","ENSG00000100603","TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; mRNA Splicing - Major Pathway; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling","Spliceosome; Notch signaling pathway; Epstein-Barr virus infection; Viral carcinogenesis",576.8,599.5,572.4,1244.7,647.7,493.2,0.733023138832998,-0.4480693552557855,0.40689582730026513,0.3905167637956736,0.632624974026378,0.19885366751394187,5022]
["High","Q13574","Diacylglycerol kinase zeta [OS=Homo sapiens]",13,10,17,10,1117,124.1,9.04,42.38,"","","","","","","","",571,604.7,617.5,626.5,626,621.7,0.9567815601323231,-0.06373850986849401,0.12505295950293074,0.9029060258000682,0.3216118273382356,0.4926679883648755,3036]
["High","Q13615","myotubularin-related protein 3 [OS=Homo sapiens]",4,4,4,4,1198,133.5,5.8,7.86,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;other cell component","other molecular function","MTMR3","ENSG00000100330","","Synthesis of PIPs at the plasma membrane; Macroautophagy","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Autophagy",214.4,212.2,199.5,180,157.3,185.4,1.1978190166443468,0.26040994192109873,0.024369491018561836,1.613153541399534,0.12651395337295931,0.897861572996522,1504]
["High","Q13636","ras-related protein rab-31 [OS=Homo sapiens]",17,3,4,3,194,21.6,7.06,11.98,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB31","ENSG00000168461","","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","Endocytosis",293.1,296.6,270,280.2,280.9,245.1,1.0663607045398167,0.09269552311448315,0.2852025966540195,0.54484652472698,0.5166732887876065,0.2867839902290762,4310]
["High","Q13637","Ras-related protein Rab-32 [OS=Homo sapiens]",9,2,2,2,225,25,6.54,5.58,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB32","ENSG00000118508","","RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","",163.6,174.2,179.4,183.5,180.6,177.7,0.954595791805094,-0.06703811839176027,0.17235835036157252,0.7635676711878393,0.3848367170783981,0.4147234988384486,3497]
["High","Q13794","phorbol-12-myristate-13-acetate-induced protein 1 [OS=Homo sapiens]",41,2,3,2,54,6,10.29,7.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus","","PMAIP1","ENSG00000141682","miRNA regulation of DNA damage response; TP53 network; Apoptosis modulation and signaling; Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; miRNA regulation of p53 pathway in prostate cancer; Chromosomal and microsatellite instability in colorectal cancer ; Unfolded protein response; p53 transcriptional gene network; DNA damage response; DNA damage response (only ATM dependent)","TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation of NOXA and translocation to mitochondria","Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Pathways in cancer; Viral carcinogenesis; Colorectal cancer",98.7,93.6,100.8,82.4,74.5,78.4,1.2456438589035275,0.31689164746524395,0.003517224275132788,2.4537999380955853,0.04784405425128364,1.3201720258349234,574]
["High","Q13838-1","spliceosome RNA helicase DDX39B [OS=Homo sapiens]",60,24,220,12,428,49,5.67,471.31,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BAT1; DDX39B; LOC101341139","ENSANAG00000030372; ENSCANG00000041217; ENSCCAG00000027897; ENSCJAG00000003152; ENSECAG00000007750; ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439; ENSGGOG00000005989; ENSMFAG00000034233; ENSMICG00000017349; ENSMLEG00000043791; ENSMMUG00000008839; ENSMNEG00000041059; ENSMODG00000015791; ENSOANG00000008361; ENSPANG00000018609; ENSPCOG00000018656; ENSPCTG00005013682; ENSPPAG00000043072; ENSPPYG00000016433; ENSPTRG00000032509; ENSRROG00000039517; ENSSHAG00000003209; ENSSSCG00000001400; ENSSSCG00005031872; ENSSSCG00015055352; ENSSSCG00025077755; ENSSSCG00030066086; ENSSSCG00035021438; ENSSSCG00040071129; ENSSSCG00045038130; ENSSSCG00050005792; ENSSSCG00055028973; ENSSSCG00060042375; ENSSSCG00065025136; ENSSSCG00070024145; ENSVURG00010001931","","Transport of Mature mRNA derived from an Intron-Containing Transcript; RHOBTB2 GTPase cycle; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",8922.2,9148.5,9291.7,8848.6,9755.1,9439.4,0.9757266493362006,-0.03545106275730261,0.4728664669195365,0.32526148266075544,0.685507124713654,0.1639880270776117,5386]
["High","Q13884","Beta-1-syntrophin [OS=Homo sapiens]",2,1,1,1,538,58,8.63,2.76,"other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SNTB1","ENSG00000172164","IL-18 signaling pathway","","",41.4,37.5,34.6,42.1,41.1,45.3,0.8832684824902723,-0.17907606190296319,0.09966714396771487,1.001447986575349,0.2828793384587123,0.5483987723063971,2751]
["High","Q13952-1","Nuclear transcription factor Y subunit gamma [OS=Homo sapiens]",11,5,13,5,458,50.3,6.1,18.92,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFYC","ENSG00000066136","","PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum  stress; ATF6 (ATF6-alpha) activates chaperone genes","Antigen processing and presentation; Tuberculosis",600.6,568.7,552.1,590.7,533,542.5,1.0331292761973354,0.047020790949818654,0.4655945809146388,0.3319920831102414,0.6792530806766629,0.16796838321137272,5352]
["High","Q14011","Cold-inducible RNA-binding protein [OS=Homo sapiens]",46,7,37,2,172,18.6,9.51,75.64,"cell organization and biogenesis;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CIRBP","ENSG00000099622","","","",1903.1,1914.5,1817.7,1402.9,1329.4,1408,1.3610849455353475,0.4447571084865171,2.3226082736685827E-4,3.6340240312371193,0.014743841789271784,1.8313893380178818,123]
["High","Q14108-1","Lysosome membrane protein 2 [OS=Homo sapiens]",13,6,21,6,478,54.3,5.14,38.78,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCARB2","ENSG00000138760","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome","Cargo recognition for clathrin-mediated endocytosis","Lysosome",881.9,944.1,996.9,870.5,874.9,869.5,1.0795441508279475,0.1104222474160004,0.10559359553115545,0.9763624218573826,0.2912309409774856,0.5357624865638503,2831]
["High","Q14119","Vascular endothelial zinc finger 1 [OS=Homo sapiens]",11,5,10,3,521,56.9,9.52,26.17,"stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","VEZF1","ENSG00000136451","","","",88.7,89.4,82.5,75.8,81.5,81.3,1.0922045264040234,0.12724304087290644,0.06356660568607204,1.196770978300009,0.2149536843641622,0.6676551065585499,2309]
["High","Q14155-1","Isoform 1 of Rho guanine nucleotide exchange factor 7 [OS=Homo sapiens]",24,15,41,12,646,73.1,7.21,77.89,"","","","ARHGEF7","","","","",2010.3,1992.9,1986.9,2139,2017.5,2096.7,0.9579255421224333,-0.062014572731123124,0.07304842837368163,1.1363891234118213,0.23423496046887315,0.630348284303839,2435]
["High","Q14165","Malectin [OS=Homo sapiens]",41,13,56,13,292,32.2,5.41,127.57,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","MLEC","ENSG00000110917","","Neutrophil degranulation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle","",2987.3,3143.7,3296.1,2892.1,3176.5,2971.8,1.042774655988673,0.060427424576265015,0.3536875014240279,0.4513802869720265,0.5865743439079885,0.23167693648478815,4708]
["High","Q14185","Dedicator of cytokinesis protein 1 [OS=Homo sapiens]",9,13,21,13,1865,215.2,7.56,36.41,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DOCK1","ENSG00000150760","Integrin-mediated cell adhesion; Focal adhesion; Hepatocyte growth factor receptor signaling; Regulation of actin cytoskeleton","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; DCC mediated attractive signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases","Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection",663.8,681,676,627.6,666.2,651.1,1.0390251426808577,0.05523056548573266,0.10961062189676384,0.9601473581907911,0.2985140341018249,0.5250352464786402,2867]
["High","Q14197","Peptidyl-tRNA hydrolase ICT1, mitochondrial [OS=Homo sapiens]",17,3,3,3,206,23.6,10.07,2.99,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL58","ENSG00000167862","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",21.1,30.3,16.5,32.2,24.7,23.3,0.8466334164588529,-0.24019066221018842,0.45053431612107636,0.3462721242533201,0.6676355931435498,0.17546051816747302,5269]
["High","Q14247-1","Src substrate cortactin [OS=Homo sapiens]",52,29,112,29,550,61.5,5.4,244.18,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CTTN","ENSG00000085733; ENSG00000288401","Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma","Clathrin-mediated endocytosis; RHO GTPases activate PAKs","Tight junction; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Proteoglycans in cancer",6346.5,6169.2,5653.1,6743.4,5974.3,6198.9,0.9604685831491919,-0.058189670664587606,0.46488021328076085,0.3326589383207969,0.678845091695564,0.16822931776250216,5347]
["High","Q14315","Filamin-C [OS=Homo sapiens]",65,139,716,120,2725,290.8,5.97,1666.9,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","FLNC","ENSG00000128591","Focal adhesion; MAPK signaling pathway; Ebola virus infection in host","Cell-extracellular matrix interactions","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer",20705.6,22036.4,21131.9,16614.4,16484.9,16742.9,1.2815224849625415,0.3578587916684079,3.0395966063772152E-4,3.51718404903894,0.01671350021309387,1.776932588763361,142]
["High","Q14332","Frizzled-2 [OS=Homo sapiens]",2,2,2,1,565,63.5,8.1,3.91,"cell-cell signaling;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","FZD2","ENSG00000180340","MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Asymmetric localization of PCP proteins; Ca2+ pathway; Class B/2 (Secretin family receptors); Disassembly of the destruction complex and recruitment of AXIN to the membrane","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",70.7,77.4,59.2,81.8,63.2,80.2,0.9205150976909415,-0.11948671097081465,0.4961394142291,0.3043962704395846,0.703059264301418,0.15300806463273425,5510]
["High","Q14457","Beclin-1 [OS=Homo sapiens]",18,9,12,9,450,51.9,4.89,21.14,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BECN1","ENSG00000126581","Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; Malignant pleural mesothelioma; Alzheimer's disease","Ub-specific processing proteases; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Autophagy; Mitophagy; Autophagy; Apoptosis; Apelin signaling pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Kaposi sarcoma-associated herpesvirus infection",510,484.6,471.4,485.1,478.1,462.6,1.0281946977135643,0.040113477401159385,0.36528163816260156,0.4373721581879863,0.5975526986745429,0.22362378789559484,4773]
["High","Q14527","Helicase-like transcription factor [OS=Homo sapiens]",31,25,42,25,1009,113.9,8.6,87.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HLTF","ENSG00000071794","Retinoblastoma gene in cancer","E3 ubiquitin ligases ubiquitinate target proteins","",1932,1780,1946.7,2397.4,2379.6,2500.9,0.7775182401516921,-0.3630515744123261,1.1719550146012646E-3,2.93108905835666,0.0297098206298918,1.5270999701984687,308]
["High","Q14596-1","Next to BRCA1 gene 1 protein [OS=Homo sapiens]",7,4,6,4,966,107.3,5.12,13.95,"other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NBR1","ENSG00000188554","","Pexophagy","Mitophagy",194.9,191.9,183.9,197,178.4,181,1.0257009345794392,0.0366101431342112,0.5147957419376488,0.28836505396001816,0.7177723487587788,0.14401327630758318,5600]
["High","Q14657","EKC/KEOPS complex subunit LAGE3 [OS=Homo sapiens]",21,2,5,2,143,14.8,8.63,9.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","LAGE3","ENSG00000196976","","tRNA modification in the nucleus and cytosol","",122.8,118.4,103.9,138.8,92.7,104.1,1.0283075089392133,0.040271757995692326,0.8430452070462029,0.0741491363547359,0.9238592247883162,0.034394200376648275,7125]
["High","Q14671-3","Isoform 3 of Pumilio homolog 1 [OS=Homo sapiens]",21,22,57,1,1188,126.6,6.84,117.66,"","","","PUM1","","","","",13.5,11.1,17.7,11.2,18.2,9.1,1.0987012987012985,0.13579921753768578,0.7253113786482219,0.1394755092949452,0.8585856950402239,0.06621635160879098,6596]
["High","Q14681","BTB/POZ domain-containing protein KCTD2 [OS=Homo sapiens]",24,3,6,2,263,28.5,5.29,11.77,"cell organization and biogenesis;protein metabolism;other metabolic processes","other cell component","other molecular function","KCTD2","ENSG00000180901","","","",23,23.1,15.3,24.8,15.2,19.8,1.0267558528428093,0.03809317117207433,0.8948733470589302,0.04823842676866024,0.9462582738131265,0.023990310127880506,7384]
["High","Q14691","DNA replication complex GINS protein PSF1 [OS=Homo sapiens]",40,6,16,6,196,23,7.39,36.45,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;developmental processes","nucleus;other cell component","","GINS1","ENSG00000101003","","Unwinding of DNA","",578.6,586.4,573.1,612.4,603.1,569.7,0.9736164015236387,-0.03857462301741029,0.3103161925346842,0.5081955620085444,0.5442382819655917,0.2642109130125797,4452]
["High","Q14697-2","Isoform 2 of Neutral alpha-glucosidase AB [OS=Homo sapiens]",61,47,354,1,966,109.4,6.24,762.7,"","","","GANAB","","","","",679.2,681.8,726.6,766.9,703,740.2,0.9445726437717749,-0.08226634138734427,0.16522962730800245,0.7819120767328156,0.37546942084426166,0.4254254272333849,3436]
["High","Q14739","Lamin-B receptor [OS=Homo sapiens]",24,17,59,17,615,70.7,9.36,103.64,"other metabolic processes;developmental processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","LBR","ENSG00000143815","Gastric cancer network 2; ATM signaling in development and disease ; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias","RHOC GTPase cycle; RHOA GTPase cycle; RHOD GTPase cycle; Regulation of MECP2 expression and activity; CDC42 GTPase cycle; RAC1 GTPase cycle; Cholesterol biosynthesis; Initiation of Nuclear Envelope (NE) Reformation; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","Steroid biosynthesis; Metabolic pathways",3416.2,3653.3,3550.9,3558.2,3516.3,3486.3,1.0056435118551625,8.11897827956427E-3,0.7955927530884959,0.09930918144002425,0.8958736971610867,0.04775321410176678,6934]
["High","Q14790-4","Isoform 4 of Caspase-8 [OS=Homo sapiens]",20,6,8,6,496,57.7,5.43,17.84,"","","","CASP8","","","","",303.4,267.2,289.2,324.8,318.5,326.5,0.886574551453908,-0.1736861434130282,0.027465919459325312,1.5612058577958203,0.13538756258738133,0.8684212303906597,1584]
["High","Q14894","Ketimine reductase mu-crystallin [OS=Homo sapiens]",26,6,9,6,314,33.8,5.14,14.17,"other metabolic processes;transport;other biological processes","cytosol;other cytoplasmic organelle;other cell component","other molecular function","CRYM","ENSG00000103316","","Lysine catabolism","",361.2,366.8,366.4,304.7,341.1,345.9,1.1035595442170012,0.14216447450107547,0.05961382046131389,1.224653044718095,0.20742634142688898,0.6831360926435833,2244]
["High","Q14974","Importin subunit beta-1 [OS=Homo sapiens]",54,37,300,37,876,97.1,4.78,636.72,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","KPNB1","ENSG00000108424","Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome","Neutrophil degranulation; Assembly of the ORC complex at the origin of replication; Apoptosis induced DNA fragmentation; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Regulation of cholesterol biosynthesis by SREBP (SREBF); Initiation of Nuclear Envelope (NE) Reformation; Postmitotic nuclear pore complex (NPC) reformation; Inhibition of nitric oxide production","Nucleocytoplasmic transport; Chemical carcinogenesis",10442.1,10654,10716.2,10389.1,10714.7,10753.1,0.9985999893272729,-2.0212036384340574E-3,0.9217579412370398,0.035383112121011126,0.9607643846187167,0.017383104533385915,7491]
["High","Q14BN4","Sarcolemmal membrane-associated protein [OS=Homo sapiens]",22,18,27,18,828,95.1,5.47,58.18,"other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","SLMAP","ENSG00000163681","","","",953.8,951.9,959.5,1016.9,995.4,1015,0.9464539358504277,-0.07939580357787707,1.7238590400852527E-3,2.763498249309437,0.033904008526412226,1.4697489514139168,397]
["High","Q15006","ER membrane protein complex subunit 2 [OS=Homo sapiens]",34,9,37,9,297,34.8,6.57,77.06,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC2","ENSG00000104412","","","",911.4,852.8,896.7,829.8,855.8,843.3,1.0521966072205307,0.07340430326174494,0.08300651024264039,1.0808878443519268,0.2532687893608973,0.5964183255804769,2559]
["High","Q15007","Pre-mRNA-splicing regulator WTAP [OS=Homo sapiens]",32,10,23,10,396,44.2,5.19,66.49,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","WTAP","ENSG00000146457","","Processing of Capped Intron-Containing Pre-mRNA","",821.1,810.1,840.5,826.8,816.9,835.4,0.9970150457827437,-0.00431281863664394,0.8236762607680603,0.084243450668015,0.914701215200827,0.038720743944733835,7031]
["High","Q15022","Polycomb protein suz12 [OS=Homo sapiens]",13,7,11,7,739,83,8.81,21.89,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","SUZ12","ENSG00000178691","Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma","HCMV Early Events; Defective pyroptosis; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines","",367.8,341.6,380.7,382.3,412.4,392.3,0.9183656276326876,-0.12285944870548339,0.0900623669557639,1.045456643401078,0.2657622680236601,0.5755066785939246,2646]
["Medium","Q15035","Translocating chain-associated membrane protein 2 [OS=Homo sapiens]",2,1,1,1,370,43.3,9.22,1.96,"cell organization and biogenesis;other metabolic processes;transport","other membranes;ER/Golgi","","TRAM2","ENSG00000065308","","","",54.4,76.1,61.8,54.5,56,60.8,1.1225919439579686,0.16683361125589838,0.351656871245982,0.45388089221315414,0.5841993299337505,0.23343894549023622,4700]
["High","Q15047","Histone-lysine N-methyltransferase SETDB1 [OS=Homo sapiens]",16,19,52,19,1291,143.1,6.02,98.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETDB1","ENSG00000143379","Histone modifications; Malignant pleural mesothelioma","PKMTs methylate histone lysines","Lysine degradation; Metabolic pathways; Signaling pathways regulating pluripotency of stem cells",1946.2,1951.5,1976.1,2292.7,2356.4,2292.2,0.846210364052843,-0.24091173952153722,1.0581416897806357E-4,3.975456174484406,0.010592269633086158,1.9750109725162508,78]
["High","Q15054","DNA polymerase delta subunit 3 [OS=Homo sapiens]",23,11,24,11,466,51.4,9.35,42.02,"DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","POLD3","ENSG00000077514","Homologous recombination; Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Dual Incision in GG-NER; Termination of translesion DNA synthesis; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)","DNA replication; Base excision repair; Nucleotide excision repair; Mismatch repair; Homologous recombination",1054.4,978,958,1108.4,1118.9,1090.8,0.9012386606793044,-0.15001889230605117,0.023127339623625752,1.6358743219734189,0.12292598215198765,0.9103563131050401,1469]
["High","Q15070-1","Mitochondrial inner membrane protein OXA1L [OS=Homo sapiens]",11,5,7,5,435,48.5,9.45,14.77,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;other cell component","translation activity;other molecular function","OXA1L","ENSG00000155463","","Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination","Protein export",509.4,504.3,531.7,611.4,585.6,572.7,0.8732553540148048,-0.19552451193435239,0.006153381265122582,2.2108861750778996,0.06280470708245375,1.202007805572882,765]
["Medium","Q15121","Astrocytic phosphoprotein PEA-15 [OS=Homo sapiens]",8,1,1,1,130,15,5.02,2.31,"transport;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus","","PEA15","ENSG00000162734","Apoptosis modulation and signaling","RAF/MAP kinase cascade; RAF-independent MAPK1/3 activation","",98.2,92.6,89.1,104.5,87.7,95.5,0.97288842544317,-0.03965373416637205,0.6627397807469158,0.17865696023680194,0.8180006652026428,0.08724634315787058,6326]
["High","Q15149-3","Isoform 3 of Plectin [OS=Homo sapiens]",41,185,463,1,4570,517.7,5.74,980.82,"","","","PLEC","","","","",12.6,15.2,13.4,14,14.6,13.8,0.9716981132075471,-0.04141992737998096,0.6455470832456052,0.19007207679330557,0.8071147519586366,0.09306471484482445,6245]
["High","Q15172-1","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [OS=Homo sapiens]",5,2,2,2,486,56.2,6.71,3.11,"protein metabolism;other metabolic processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP2R5A","ENSG00000066027; ENSGGOG00000014986; ENSNLEG00000002787; ENSPPAG00000015631; ENSPPYG00000000237; ENSPTRG00000001958","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; Glycogen metabolism","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Separation of Sister Chromatids; RAF activation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; Dopaminergic synapse; Human papillomavirus infection",65,63.8,70.9,64.7,81.3,66.5,0.9397647058823532,-0.08962850846845354,0.4956383283311507,0.3048351164624731,0.7028594383599027,0.15313151886114917,5506]
["High","Q15233","Non-POU domain-containing octamer-binding protein [OS=Homo sapiens]",58,27,490,25,471,54.2,8.95,715.13,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","NONO","ENSG00000147140","mRNA processing","","",13743.2,12329.2,12762.5,13086.9,13434.7,13453.3,0.9714821050209007,-0.041740673688559424,0.43156684801538003,0.36495192422307193,0.6534174809587139,0.18480925097115133,5157]
["High","Q15283-1","ras GTPase-activating protein 2 [OS=Homo sapiens]",8,6,6,6,850,96.6,7.2,14.19,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;other molecular function","RASA2","ENSG00000155903","MAPK signaling pathway; Ebola virus infection in host; Ras signaling; Modulators of TCR signaling and T cell activation","Regulation of RAS by GAPs","MAPK signaling pathway; Ras signaling pathway; Viral carcinogenesis",340.4,361.9,386.3,358,383.1,339.9,1.0070305272895466,0.01010741810308111,0.896247468269938,0.04757205812241245,0.9464295688736375,0.023911699700865034,7394]
["High","Q15365","Poly(RC)-binding protein 1 [OS=Homo sapiens]",84,18,347,12,356,37.5,7.09,948.55,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCBP1","ENSG00000169564","Ferroptosis","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Spliceosome; Ferroptosis",9442.3,9735.5,9655.5,10058.1,9812.8,10007,0.9650377034530538,-0.05134278616244824,0.0389282504903747,1.4097351138633827,0.16555107833815122,0.781067986069971,1836]
["High","Q15366-1","Poly(rC)-binding protein 2 [OS=Homo sapiens]",65,16,384,1,365,38.6,6.79,990.65,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101348589; Pcbp2; PCBP2","ENSBIXG00000004442; ENSCAFG00000006821; ENSG00000197111; ENSRNOG00000036852","mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation","mRNA Splicing - Major Pathway; Negative regulators of DDX58/IFIH1 signaling; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway","Ferroptosis",337.4,361.8,370.7,319.2,315.2,316.4,1.125262936474548,0.17026215062028333,0.016672107262828934,1.7780095042643946,0.10617929323667889,0.9739601697881555,1226]
["High","Q15390","Mitochondrial fission regulator 1 [OS=Homo sapiens]",9,3,6,3,333,37,9.01,10.91,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;mitochondrion","","MTFR1","ENSG00000066855","","","",283.1,284.9,291.8,299.5,283.8,282.1,0.993529003928819,-0.009366010438589383,0.7762873698722925,0.10997747971239229,0.8866664400179725,0.05223972910245613,6836]
["High","Q15427","Splicing factor 3b subunit 4 [OS=Homo sapiens]",27,8,35,8,424,44.4,8.56,70.93,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","SF3B4","ENSG00000143368","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",1000.6,1041.9,1002.6,1097.1,1064.2,1072.6,0.9416184792355978,-0.08678546138446018,0.019550157085262854,1.7088497487034715,0.11599363717456868,0.9355658333227729,1316]
["High","Q15438-1","Cytohesin-1 [OS=Homo sapiens]",14,3,3,2,398,46.4,5.54,9.12,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CYTH1","ENSCATG00000038229; ENSG00000108669; ENSMFAG00000037544; ENSMMUG00000013313; ENSPANG00000019854; ENSPTRG00000009717","","Intra-Golgi traffic","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection",23.1,14.9,20,19.7,23.9,17,0.957095709570957,-0.06326489345801656,0.7950515819670538,0.09960469393857113,0.8956518182078713,0.04786078812702953,6931]
["High","Q15542","Transcription initiation factor TFIID subunit 5 [OS=Homo sapiens]",24,11,28,11,800,86.8,5.64,63.38,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","TAF5","ENSG00000148835","Eukaryotic transcription initiation","Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors",608,643.5,632.8,631.1,647,632,0.9864928537772892,-0.01961949488369647,0.5034389821993552,0.298053159271159,0.7085168660801308,0.1496498070137709,5548]
["High","Q15560","transcription elongation factor A protein 2 [OS=Homo sapiens]",25,6,17,4,299,33.6,9.13,31.02,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","TCEA2","ENSG00000171703","","","",137.9,141.3,134.9,127.4,124,131.7,1.0809188201513964,0.11225817694599831,0.023389257946494258,1.6309835565087167,0.12339413922042376,0.9087054672450386,1480]
["Medium","Q15573-1","TATA box-binding protein-associated factor RNA polymerase I subunit A [OS=Homo sapiens]",2,1,1,1,450,52.6,9.1,2.59,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus","nucleic acid binding activity","TAF1A","ENSG00000143498","","RNA Polymerase I Transcription Initiation; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; SIRT1 negatively regulates rRNA expression; RNA Polymerase I Transcription Termination","",26.6,25.2,21.6,30,18.3,29,0.9495472186287194,-0.07468835108163446,0.7631559594238034,0.11738670005853988,0.8793863239641466,0.055820292722554954,6776]
["High","Q15637-5","Isoform 5 of Splicing factor 1 [OS=Homo sapiens]",25,13,62,13,673,71.7,9.58,126.09,"","","","SF1","","","","",2914,3006.2,2828.5,3328.5,2928.4,3061.9,0.9388225951839294,-0.09107553043624628,0.21272589057594665,0.6721796494955545,0.4370957246360504,0.3594234414537293,3800]
["High","Q15678","Tyrosine-protein phosphatase non-receptor type 14 [OS=Homo sapiens]",9,7,12,7,1187,135.2,8.31,17.6,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN14","ENSG00000152104","VEGFA-VEGFR2 signaling pathway","Interleukin-37 signaling","",218.6,195.8,258.6,218.8,241.1,215,0.9971847681137946,-4.0672488956177595E-3,0.9763477389196976,0.01039547516454505,0.9867102181575199,0.005810374314711189,7726]
["High","Q15723-1","Isoform 1 of ETS-related transcription factor Elf-2 [OS=Homo sapiens]",3,1,1,1,581,62.7,6.7,2.61,"","","","ELF2","","","","",29.3,31.4,32.4,38.2,33.8,27.8,0.9328657314629258,-0.10025864777846685,0.5173925238630993,0.28617985097405535,0.7192096895714936,0.14314447019156223,5617]
["High","Q15751","Probable E3 ubiquitin-protein ligase HERC1 [OS=Homo sapiens]",3,10,12,10,4861,531.9,6.04,18.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","HERC1","ENSG00000103657","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",282.7,308.2,278.1,277.6,274.2,275.8,1.0500241662638958,0.07042253184175333,0.2165014957648158,0.6645390988479749,0.44136910677067415,0.35519806815796223,3830]
["High","Q15800","Methylsterol monooxygenase 1 [OS=Homo sapiens]",9,2,7,2,293,35.2,7.23,14.11,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","MSMO1","ENSG00000052802","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Cholesterol biosynthesis","Steroid biosynthesis; Metabolic pathways",368.9,367.5,371.9,369.6,429,424.7,0.9059919888825309,-0.1424298014045306,0.11613015753657283,0.935054984818027,0.30883660423895115,0.5102712314034246,2936]
["High","Q15811-7","Isoform 7 of Intersectin-1 [OS=Homo sapiens]",33,30,62,29,1215,137,7.33,118.38,"","","","ITSN1","","","","",2192.9,2038,2113,2437.7,2291,2309.8,0.9013142004688499,-0.14989797393280407,0.022650761858053942,1.6449171859167413,0.12180244393091265,0.9143439976221809,1452]
["High","Q15942","Zyxin [OS=Homo sapiens]",35,12,44,12,572,61.2,6.67,85.33,"cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","ZYX","ENSG00000159840; ENSG00000285443","Integrin-mediated cell adhesion; Focal adhesion","","Focal adhesion",861.4,853.8,750.2,1042.3,771.7,700.1,0.9806292510242233,-0.0282202987153359,0.8900194743990846,0.05060049051067142,0.9449649246815409,0.024584311384879633,7354]
["High","Q16143","Beta-synuclein [OS=Homo sapiens]",30,4,13,1,134,14.3,4.41,31.63,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","cytosol;other cell component","enzyme regulator activity;other molecular function","SNCB","ENSG00000074317","","MTF1 activates gene expression","",237.2,203.7,186.8,208.8,187.4,185.1,1.079821090658868,0.11079230035119467,0.40477582954074615,0.3927854285064006,0.630836262885059,0.20008334971501093,5010]
["High","Q16513","Serine/threonine-protein kinase N2 [OS=Homo sapiens]",18,14,30,10,984,112,6.3,68.68,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","PKN2","ENSG00000065243","PI3K-Akt signaling pathway","RAC1 GTPase cycle; RHO GTPases activate PKNs; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle","PI3K-Akt signaling pathway; NOD-like receptor signaling pathway; Yersinia infection",433.4,468.4,452.6,449.1,465.6,483.5,0.9686740094407096,-0.04591686174536293,0.3613720759587184,0.44204540939982223,0.5943950219266217,0.2259248364595468,4747]
["High","Q16539-2","Isoform CSBP1 of Mitogen-activated protein kinase 14 [OS=Homo sapiens]",28,8,23,1,360,41.5,5.88,39.57,"","","","MAPK14","","","","",22.9,21.7,22.4,17.4,19.8,21.7,1.1375212224108657,0.18589346151467387,0.1048285696149253,0.9795203401080856,0.2908676160459619,0.5363046285481772,2814]
["High","Q16566","calcium/calmodulin-dependent protein kinase type IV [OS=Homo sapiens]",7,3,5,3,473,51.9,5.82,11.99,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","CAMK4","ENSG00000152495","Energy metabolism; Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway; Common pathways underlying drug addiction; Mitochondrial gene expression; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; CAMKK2 pathway; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells","Transcriptional activation of mitochondrial biogenesis; Regulation of MECP2 expression and activity; Negative regulation of NMDA receptor-mediated neuronal transmission; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; Loss of phosphorylation of MECP2 at T308","Calcium signaling pathway; cAMP signaling pathway; Longevity regulating pathway; Apelin signaling pathway; Osteoclast differentiation; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Oxytocin signaling pathway; Aldosterone synthesis and secretion; Amphetamine addiction; Alcoholism; Glioma",185.6,200.3,177.8,204.2,204.8,203.2,0.9207775236850702,-0.11907547738577996,0.07084161652588676,1.1497115372580435,0.22941988462634752,0.6393689429768619,2411]
["High","Q16629","serine/arginine-rich splicing factor 7 [OS=Homo sapiens]",35,12,87,11,238,27.4,11.82,155.06,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","other molecular function","SRSF7","ENSG00000115875","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection",4085.7,3913.7,3644,3881,3677.7,3889.8,1.017024064287898,0.024353815889687398,0.679403639540167,0.1678721309602836,0.8286134985207161,0.08164799610976171,6402]
["High","Q16658","Fascin [OS=Homo sapiens]",68,33,275,33,493,54.5,7.24,687.19,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","FSCN1","ENSG00000075618","VEGFA-VEGFR2 signaling pathway","Interleukin-4 and Interleukin-13 signaling","MicroRNAs in cancer",8880.3,9001.1,9300.9,7902.8,8825.2,8387.5,1.0822918118293485,0.11408953679756861,0.07927811604364714,1.1008466789260332,0.24700859140813922,0.607287940925529,2506]
["High","Q16698","2,4-dienoyl-CoA reductase, mitochondrial [OS=Homo sapiens]",26,6,11,6,335,36,9.28,28.23,"other metabolic processes;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","DECR1","ENSG00000104325","Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway","mitochondrial fatty acid beta-oxidation of unsaturated fatty acids","",222,235.6,235.7,242.8,245.2,245.4,0.9453231524406872,-0.08112050552287879,0.04459058265729011,1.350756852763811,0.17863687500673225,0.748028887222797,1949]
["High","Q16774-1","guanylate kinase [OS=Homo sapiens]",21,4,11,4,197,21.7,6.55,26.05,"other metabolic processes;transport","cytosol;other cell component","kinase activity;other molecular function","GUK1","ENSG00000143774","","Interconversion of nucleotide di- and triphosphates; Abacavir metabolism","Purine metabolism; Metabolic pathways",718.2,765.1,736.6,663.7,643.8,613.6,1.1555358908958409,0.2085620705483375,7.538651575576513E-3,2.122706328620549,0.06900561723575781,1.1611155551294365,853]
["High","Q16799-1","Reticulon-1 [OS=Homo sapiens]",4,2,2,1,776,83.6,4.69,6.67,"developmental processes;other biological processes","other membranes;ER/Golgi","","RTN1","ENSG00000139970","","","",23,17.5,18.4,19.2,11,18.6,1.2069672131147542,0.27138648626757456,0.3441455076100725,0.46325789524547983,0.5769998117714078,0.23882432851957577,4657]
["Medium","Q16854","Deoxyguanosine kinase, mitochondrial [OS=Homo sapiens]",3,1,1,1,277,32,8.66,2.25,"protein metabolism;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","DGUOK","ENSG00000114956","","Purine salvage","Purine metabolism; Metabolic pathways",86.7,75.9,92,80.7,111.7,94.4,0.8877266387726639,-0.1718126048005468,0.3496432737759467,0.4563748220357483,0.5820926826530046,0.23500786009219618,4690]
["High","Q1KMD3","heterogeneous nuclear ribonucleoprotein U-like protein 2 [OS=Homo sapiens]",55,37,154,37,747,85.1,4.91,356.2,"","nucleus","","HNRNPUL2","ENSG00000214753","","","",6018.4,5934.3,5887.1,5752.4,5765.3,6086.7,1.0133716570857287,0.01916338391024931,0.5355022920634916,0.27123866595556856,0.7334155229664521,0.13464990230106508,5701]
["High","Q2M1P5","Kinesin-like protein KIF7 [OS=Homo sapiens]",16,16,22,15,1343,150.5,6.79,36.2,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF7","ENSG00000166813","Hedgehog signaling pathway; Hedgehog signaling pathway; Ciliopathies","Hedgehog 'on' state; Hedgehog 'off' state","Hedgehog signaling pathway; Pathways in cancer; Basal cell carcinoma",691.6,731.3,686.1,743.2,633,700.9,1.0153579509893602,0.021988420099176637,0.7771160006079387,0.10951414894203534,0.8867049149125801,0.05222088427971096,6843]
["High","Q2NKX8","Dna excision repair protein ercc-6-like [OS=Homo sapiens]",28,28,42,28,1250,141,5.31,93.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","ERCC6L","ENSG00000186871","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",1792.8,1950.6,1887.5,1774.6,1726.6,1788.9,1.064422222642294,0.09007053587971968,0.08372565777201597,1.0771414318366503,0.2545677320420174,0.5941966465748307,2568]
["Low","Q2TAK8-1","PWWP domain-containing protein MUM1 [OS=Homo sapiens]",2,1,1,1,710,78.6,8.54,0,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","other molecular function","PWWP3A","ENSG00000160953","IL-18 signaling pathway","","",32.2,27.8,35.2,55.8,49.9,66.3,0.5534883720930233,-0.8533750862815167,0.008212513513478,2.085523902811268,0.07237393398785127,1.1404178200396833,886]
["High","Q2TAZ0-1","Autophagy-related protein 2 homolog A [OS=Homo sapiens]",9,11,13,11,1938,212.7,5.88,25.74,"cell organization and biogenesis;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ATG2A","ENSG00000110046","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease","","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",270.3,267.5,274,260.8,234.5,235.3,1.111141527511634,0.15204258633567483,0.03758050805565364,1.4250373529136358,0.1621152524301346,0.790176123124185,1810]
["High","Q32P28-1","Prolyl 3-hydroxylase 1 [OS=Homo sapiens]",42,25,107,23,736,83.3,5.14,239.1,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","P3H1","ENSG00000117385","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",4197.9,4592.2,4162.5,4172.7,4011.6,4092.9,{"$f":"AVERAGE(T3522:V3522)/AVERAGE(W3522:Y3522)","v":1.0550125435767113},{"$f":"LOG(Z3522,2)","v":0.0772601519640589},{"$f":"TTEST(T3522:V3522,W3522:Y3522,2,2)","v":0.19633717508108092},{"$f":"-LOG10(AB3522)","v":0.7069974619689402},{"$f":"AB3522*7808/AF3522","v":0.414660714912924},{"$f":"-LOG10(AD3522)","v":0.38230710788341155},3697]
["Low","Q3C1V8","Brain-specific homeobox protein homolog [OS=Homo sapiens]",6,1,1,1,233,25.9,7.5,0,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BSX","ENSG00000188909","","","",140.1,125.6,168.7,150.3,165.4,158.8,0.915489989462592,-0.12738398410411056,0.3748081517471436,0.4261909721591171,0.605399679114956,0.2179578135721133,4834]
["High","Q3KR37","GRAM domain-containing protein 1B [OS=Homo sapiens]",3,2,2,2,738,85.3,6.21,2.16,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","GRAMD1B","ENSG00000023171","Ectoderm differentiation","","",31.6,36.1,34.7,32.9,32.7,36.3,1.0049067713444555,0.007061663834186388,0.929501080640802,0.03175010097969489,0.964714135005102,0.015601358140247067,7523]
["High","Q3T8J9-1","GON-4-like protein [OS=Homo sapiens]",7,9,10,8,2241,248.5,5.01,14.2,"developmental processes;other biological processes","nucleus","other molecular function","GON4L","ENSG00000116580","","","",257.7,232.9,246.6,248.1,226.2,252,1.0150075726283905,0.02149049091062049,0.7527243677887283,0.12336402441360572,0.8744638987791089,0.058258115155749565,6721]
["High","Q3YEC7-1","Rab-like protein 6 [OS=Homo sapiens]",24,15,40,15,729,79.5,5.22,51.27,"","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RABL6","ENSG00000196642","","","",1213.1,1125.7,1186.4,1255.3,1166.6,1204.4,0.9721203430493893,-0.040793172441461995,0.40760201525883405,0.38976367742903706,0.633470647918188,0.19827350349954137,5024]
["High","Q49A26-5","Isoform 5 of Putative oxidoreductase GLYR1 [OS=Homo sapiens]",39,11,34,2,472,51.5,8.27,60.96,"","","","","","","","",34.4,60.7,29.8,40.3,30.9,31.8,1.212621359223301,0.2781291395373767,0.509047229264642,0.2932419220690027,0.712684376205545,0.14710276190192828,5577]
["High","Q4G0N4","NAD kinase 2, mitochondrial [OS=Homo sapiens]",6,2,4,2,442,49.4,8.18,10.44,"other metabolic processes","mitochondrion","kinase activity;other molecular function","NADK2","ENSG00000152620","","Nicotinate metabolism","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors",154.3,172.9,210.3,154.9,192.2,188.5,1.003547423450336,5.108794039874476E-3,0.9766010616864694,0.010282807919676838,0.9865831400760711,0.005866310558949891,7729]
["High","Q4G148-1","Glucoside xylosyltransferase 1 [OS=Homo sapiens]",13,5,12,5,440,50.5,8.65,15.35,"protein metabolism;other metabolic processes","other membranes","other molecular function","GXYLT1","ENSG00000151233","","","Other types of O-glycan biosynthesis",489,532.9,540.4,491,478,484.5,1.0748538011695905,0.10414044151577412,0.09236030396376287,1.0345146464611445,0.27029582209485026,0.5681606670470204,2668]
["High","Q4V328","GRIP1-associated protein 1 [OS=Homo sapiens]",57,35,105,35,841,95.9,5.11,236.5,"","","","","","","","",3332,3314.3,3314.8,3603.2,3139.5,3251.5,0.9966880790858698,-4.7860217233632865E-3,0.9408909515133171,0.026460708029027728,0.9707289309482003,0.01290202676412868,7568]
["High","Q4ZIN3-1","Membralin [OS=Homo sapiens]",4,3,5,3,620,67.8,5.3,7.84,"stress response;other biological processes","other membranes;ER/Golgi","","TMEM259","ENSG00000182087","","","",270,281.7,308.5,268,235.4,243.5,1.1516936671575848,0.2037570330626207,0.06585899730161546,1.1813848856752858,0.21891317621584228,0.6597280977942563,2349]
["High","Q53EP0","Fibronectin type III domain-containing protein 3B [OS=Homo sapiens]",6,5,8,5,1204,132.8,5.95,11.71,"","other membranes","","FNDC3B","ENSG00000075420","","","",126.2,126.4,121.5,131.4,125.6,112,{"$f":"AVERAGE(T3586:V3586)/AVERAGE(W3586:Y3586)","v":1.0138211382113822},{"$f":"LOG(Z3586,2)","v":0.019803149603067963},{"$f":"TTEST(T3586:V3586,W3586:Y3586,2,2)","v":0.7898957245762238},{"$f":"-LOG10(AB3586)","v":0.1024302368490116},{"$f":"AB3586*7808/AF3586","v":0.89306484469898},{"$f":"-LOG10(AD3586)","v":0.04911700620381164},6906]
["High","Q53G59-1","Kelch-like protein 12 [OS=Homo sapiens]",20,8,12,7,568,63.2,5.44,18.03,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","KLHL12","ENSCANG00000030198; ENSCATG00000031800; ENSG00000117153; ENSGGOG00000009159; ENSMLEG00000023751; ENSMMUG00000017849; ENSMNEG00000042480; ENSPPAG00000041960; ENSPTRG00000001861; ENSRBIG00000033303; ENSRROG00000044766","","Degradation of DVL","",354.8,360.3,380.2,354.1,358.2,353,1.0281610813855253,0.04006630841391309,0.2730229827899993,0.5638007929638008,0.503486879930164,0.29801184198855857,4234]
["Medium","Q53HI1","protein unc-50 homolog [OS=Homo sapiens]",2,1,2,1,259,30.4,9.47,4.67,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity","UNC50","ENSG00000115446","","","",178.7,194.9,197.1,227.7,240.7,231.9,0.8149364558046553,-0.29524052446334825,0.00341302445530035,2.466860599865532,0.047587312405330595,1.3225088222130972,560]
["High","Q53HV7-1","single-strand selective monofunctional uracil DNA glycosylase [OS=Homo sapiens]",8,2,3,2,270,29.8,6.62,7.09,"DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","nucleic acid binding activity;other molecular function","SMUG1","ENSG00000123415; ENSPPAG00000033677","Fluoropyrimidine activity; Base excision repair; DNA repair pathways, full network","Displacement of DNA glycosylase by APEX1; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine","Base excision repair",121.3,116.9,129.5,114.9,121.9,127.4,1.0096101043382755,0.01379825422645776,0.8324818291197034,0.0796252372200437,0.9188603508293248,0.03675048804014106,7074]
["High","Q587I9","vesicle transport protein SFT2C [OS=Homo sapiens]",27,4,12,4,215,21.8,9.89,39.1,"transport","other membranes","","SFT2D3","ENSG00000173349","","","",372.5,368.4,332.5,328.7,363.7,335,1.044773213938096,0.0631898144261051,0.4093777932910672,0.3878757193499233,0.6350927498542922,0.1971628450884274,5033]
["High","Q587J7-1","Putative ATP-dependent RNA helicase TDRD12 [OS=Homo sapiens]",15,15,33,15,1177,132.5,6.74,54.58,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","other cell component","nucleic acid binding activity;other molecular function","TDRD12","ENSG00000173809","","PIWI-interacting RNA (piRNA) biogenesis","",1046.3,985.7,1108.5,1250.8,1449.6,1321.7,0.7808110191193656,-0.35695468194981994,0.012507340147519395,1.9028350389937343,0.09161098674655857,1.0380524390256523,1066]
["High","Q5BJF2","sigma intracellular receptor 2 [OS=Homo sapiens]",10,2,10,2,176,20.8,9.38,9.4,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","","TMEM97","ENSG00000109084","","","",333.1,402.7,374.3,359.7,398.9,376.4,0.9780616740088105,-0.03200265426886961,0.7383677407036542,0.1317272858993138,0.8670740441290619,0.06194381419206902,6649]
["High","Q5EBL4-1","RILP-like protein 1 [OS=Homo sapiens]",42,12,26,12,403,47.1,5.21,59.7,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RILPL1","ENSG00000188026; ENSGGOG00000014925","","","",931.1,929.1,877.2,1123.2,1098.7,1099.6,0.8241457172964022,-0.279028651854126,5.5206161073734455E-4,3.258012451781433,0.0210268149104253,1.6772265081785518,205]
["High","Q5EBM0-1","UMP-CMP kinase 2, mitochondrial [OS=Homo sapiens]",3,1,1,1,449,49.4,7.01,3.06,"other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","kinase activity;other molecular function","CMPK2","ENSG00000134326","Pyrimidine metabolism","","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",83.8,79.6,108.3,82.1,101.3,92.4,0.9851341551849166,-0.021607891292005403,0.9029910556038787,0.044316551481752176,0.9508501904457296,0.0218879021875176,7415]
["High","Q5HYJ3-1","Protein FAM76B [OS=Homo sapiens]",17,6,9,4,339,38.7,9.25,11.8,"","nucleus","","FAM76B","ENSG00000077458","","","",238.7,219.5,213.3,202,208,199.1,1.1024462321457889,0.14070829523112877,0.061750837342703334,1.2093571489857067,0.21165519665137297,0.6743710640701528,2278]
["High","Q5JPI3","Uncharacterized protein C3orf38 [OS=Homo sapiens]",19,5,10,5,329,37.5,6.47,16.16,"other biological processes","nucleus","","C3orf38","ENSG00000179021","","","",354.2,318.5,348.7,344,333.1,348.9,0.9955165692007798,-0.006482766782000383,0.9048051733015464,0.04344492495937846,0.9519901351756467,0.021367551889663088,7421]
["High","Q5JRA6-1","Transport and Golgi organization protein 1 homolog [OS=Homo sapiens]",41,65,167,64,1907,213.6,4.84,369.78,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MIA3","ENSG00000154305","Type I collagen synthesis in the context of osteogenesis imperfecta","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER","",7340.2,7286.3,7301.9,6796.2,6426.3,6964.8,1.0862472940908394,0.11935258320161854,0.022139532502776095,1.6548315539003056,0.12088494390326976,0.9176277867067321,1430]
["High","Q5JTV8-3","Isoform 3 of Torsin-1A-interacting protein 1 [OS=Homo sapiens]",28,14,38,1,584,66.3,8.18,78.04,"","","","TOR1AIP1","","","","",19.5,19.3,21.4,21.6,18.4,15.8,1.0788530465949822,0.10949836493051458,0.46226050779446065,0.33511320796698535,0.6761577453838795,0.16995197275983878,5338]
["High","Q5M775-1","Cytospin-B [OS=Homo sapiens]",16,16,23,16,1068,118.5,6.7,44.06,"cell organization and biogenesis","other membranes;cytosol;cytoskeleton;nucleus;other cell component","","SPECC1","ENSG00000128487","","","",1137.2,1125.4,1032.5,1202,962.1,1054.1,1.0238953452240385,0.03406826158568035,0.756903853111359,0.1209592839281189,0.8767104710122372,0.05714380640827486,6741]
["High","Q5PRF9","protein Smaug homolog 2 [OS=Homo sapiens]",30,11,26,11,694,75.4,6.83,54.45,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMD4B","ENSG00000179134","","","",655,661,680,679.6,704,697,0.9593386523118332,-0.05988790971039006,0.05430873918874444,1.2651302795076298,0.1974127726190487,0.7046247518765124,2148]
["High","Q5RI15-1","Cytochrome c oxidase protein 20 homolog [OS=Homo sapiens]",22,2,3,2,118,13.3,8.76,10.54,"cell organization and biogenesis","other membranes;mitochondrion","","COX20; FAM36A","ENSG00000203667","Mitochondrial complex IV assembly","TP53 Regulates Metabolic Genes; Respiratory electron transport; Cytoprotection by HMOX1","Thermogenesis",284.2,277.3,312.3,293,330.5,322.9,0.9232882502113272,-0.1151469678955708,0.19740036384361334,0.7046520511844777,0.4164555636019813,0.3804313316209541,3701]
["Medium","Q5SNT2-1","Transmembrane protein 201 [OS=Homo sapiens]",2,1,1,1,666,72.2,9.22,1.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TMEM201","ENSG00000188807; ENSPTRG00000049393","","","",44.3,52.5,46.5,54,45.2,43.4,1.0049088359046285,0.007064627818257885,0.9572427081863878,0.018977933213731434,0.9775243350142971,0.009872422238105336,7646]
["High","Q5SRD1","Putative mitochondrial import inner membrane translocase subunit Tim23B [OS=Homo sapiens]",14,2,8,2,257,28,9.39,24.02,"","","","","","","","",323.2,376.5,392.8,342.2,461.5,403.5,0.9049867461895295,-0.14403143125136025,0.39700756964708683,0.4012012125703383,0.6254711670307614,0.20379270561572882,4956]
["High","Q5SYC1-1","Clavesin-2 [OS=Homo sapiens]",6,1,1,1,327,38,6.2,3.32,"cell organization and biogenesis","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLVS2; LOC101343624","ENSAMEG00000028872; ENSCAFG00000001006; ENSCATG00000031634; ENSCSAG00000016282; ENSDLEG00000011174; ENSECAG00000006114; ENSFCAG00000010835; ENSG00000146352; ENSGGOG00000027351; ENSLAFG00000007550; ENSMFAG00000003285; ENSMLEG00000033559; ENSMMUG00000018176; ENSMNEG00000035011; ENSNLEG00000013863; ENSOARG00000008112; ENSPANG00000003404; ENSPCOG00000011744; ENSPPAG00000036654; ENSPPYG00000016981; ENSPTRG00000018566; ENSRBIG00000041651; ENSRROG00000010239; ENSSSUG00005005271; ENSSTOG00000001439; ENSTTRG00000010743; ENSUAMG00000008720; ENSUMAG00000001385; ENSVVUG00000000265","","Lysosome Vesicle Biogenesis; Lysosome Vesicle Biogenesis","",26,21.8,34.8,25.6,18.6,23.6,1.2182890855457225,0.28485650828310116,0.3210264830967186,0.49345913897098875,0.553939177904791,0.25653791785357544,4525]
["High","Q5T0D9","Tumor protein p63-regulated gene 1-like protein [OS=Homo sapiens]",21,2,5,2,272,30.2,7.34,18.33,"other biological processes","other membranes;ER/Golgi;other cell component","","TPRG1L","ENSG00000158109","","","",86.1,86.4,75.3,87.6,82.9,84,0.9736738703339883,-0.03848946882245592,0.5990826283645989,0.22251327349055314,0.7786977130465771,0.10863110077927296,6007]
["High","Q5T160","probable arginine--tRNA ligase, mitochondrial [OS=Homo sapiens]",22,11,12,11,578,65.5,8.21,25.19,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","RARS2","ENSG00000146282","","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",513.1,394.5,533.8,425.8,484.1,475.5,1.0404215389057312,0.05716817151275857,0.7117987616977881,0.14764277186502672,0.8511063907100045,0.07001614848146526,6530]
["High","Q5T2E6-1","UPF0668 protein C10orf76 [OS=Homo sapiens]",5,3,5,3,689,78.7,6.6,10.73,"other biological processes","other membranes;cytosol;ER/Golgi","","ARMH3","ENSG00000120029; ENSNLEG00000014964; ENSPTRG00000002879","","","",146,160.2,143.7,159.5,165.2,152.7,0.9423963133640554,-0.08559419950273037,0.21928682025766788,0.6589874698335353,0.4443787938156945,0.3522466741879008,3853]
["Medium","Q5T4F4-1","Protrudin [OS=Homo sapiens]",4,1,1,1,411,45.8,5.15,0,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ZFYVE27","ENSG00000155256","","","Endocytosis",25.1,30,30.6,25.9,38.2,31.4,0.8973821989528796,-0.15620552881061112,0.4558685834564798,0.3411603365140392,0.6713357034379845,0.17306025525247848,5302]
["High","Q5T5U3-3","Isoform 3 of Rho GTPase-activating protein 21 [OS=Homo sapiens]",6,5,7,1,1164,129.2,8.44,11.46,"","","","","","","","",22.2,25.9,22.4,26.5,32.9,31,0.779867256637168,-0.358699515129032,0.04182693145972291,1.378543995304431,0.17243119368401083,0.76338416531305,1894]
["Medium","Q5T7M9-1","Protein FAM69A [OS=Homo sapiens]",3,1,1,1,428,49,7.17,0,"","other membranes;ER/Golgi","","DIPK1A","ENSG00000154511; ENSPCOG00000022059; ENSPTRG00000000964","","","",62.7,64.7,91.2,43,74.9,58.3,1.240635641316686,0.3110794767514914,0.3383471650225117,0.4706374580758501,0.5704631104503933,0.24377243441110805,4631]
["High","Q5T8A7","Protein phosphatase 1 regulatory subunit 26 [OS=Homo sapiens]",1,1,1,1,1209,127.3,8.59,3.09,"other biological processes","nucleus","enzyme regulator activity","PPP1R26","ENSG00000196422","","","",16.5,20,18.1,33.8,19.1,25.4,0.6973180076628352,-0.5201113563711882,0.14537073660695332,0.8375230089460419,0.35075856348179585,0.45499171722764126,3236]
["High","Q5TAX3","Terminal uridylyltransferase 4 [OS=Homo sapiens]",16,23,37,23,1644,185,7.97,69.36,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TUT4","ENSG00000134744","","Deadenylation of mRNA","",1561.9,1578.1,1579.5,1841.1,1759.3,1778.5,0.8774098793433603,-0.18867714417253517,9.712987235773661E-4,3.0126471819876395,0.02757781975888027,1.5594400711592669,275]
["High","Q5TC63","Growth hormone-regulated TBC protein 1 [OS=Homo sapiens]",11,3,6,3,336,38.5,8.78,2.46,"transport;other biological processes","","enzyme regulator activity","GRTP1","ENSG00000139835","","","",276,289.8,292.8,225.8,305.6,286,1.050403719109371,0.07094392942716485,0.6058757665029857,0.21761641783603974,0.7812845557151631,0.10719076065647537,6055]
["High","Q5TFE4","5'-nucleotidase domain-containing protein 1 [OS=Homo sapiens]",40,11,29,11,455,51.8,6.35,39.56,"other metabolic processes","","other molecular function","NT5DC1","ENSG00000178425","","","",1352.9,1450.1,1304.9,1319.2,1239.4,1276.4,1.07116036505867,0.09917448434170757,0.13417752126647653,0.8723202353416123,0.33514334166623444,0.47476940436614495,3126]
["High","Q5U4P2","Aspartate beta-hydroxylase domain-containing protein 1 [OS=Homo sapiens]",3,1,1,1,390,41.1,8.56,2.56,"protein metabolism;other metabolic processes","other membranes","other molecular function","ASPHD1","ENSG00000174939","16p11.2 proximal deletion syndrome","","",46.2,52.9,45.9,63.8,69.5,54.6,0.7716870675891432,-0.37391216651775866,0.04345153904103545,1.3619948363570462,0.17587849498828656,0.7547872593422954,1929]
["High","Q5VST6-1","Protein ABHD17B [OS=Homo sapiens]",6,2,5,2,288,32.2,6.29,9.62,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","Abhd17b; ABHD17B; FAM108B1; LOC111153563; LOC112838645","ENSAMEG00000007245; ENSBIXG00000020353; ENSBIXG00005014706; ENSBMUG00000011067; ENSBTAG00000006816; ENSCATG00000030905; ENSCHIG00000013948; ENSCSAG00000008296; ENSDLEG00000009276; ENSECAG00000020790; ENSG00000107362; ENSLCNG00005018778; ENSMFAG00000001017; ENSMMUG00000018880; ENSNLEG00000001017; ENSPANG00000025076; ENSPCOG00000021794; ENSPPAG00000033499; ENSPPYG00000019288; ENSRFEG00010009213; ENSRROG00000042653; ENSSBOG00000018778; ENSSSCG00070028547; ENSSSUG00005013616; ENSUAMG00000021312","","RAS processing; RAS processing","",80.7,96.8,107,73.3,74,81.2,1.2450765864332602,0.31623448724851205,0.08152654717489947,1.0887009505944305,0.2508113791732132,0.600652763694481,2538]
["High","Q5VT66-1","Mitochondrial amidoxime-reducing component 1 [OS=Homo sapiens]",31,8,27,7,337,37.5,8.88,56.93,"other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;other cell component","other molecular function","MTARC1","ENSG00000186205","","Phase I - Functionalization of compounds","",650.3,620.6,652.4,657.9,606.4,648.5,1.0054893350062735,0.007897779390495335,0.8618930225810315,0.06454663508699963,0.93156986715292,0.030784567733813606,7224]
["High","Q5VTR2","E3 ubiquitin-protein ligase BRE1A [OS=Homo sapiens]",51,45,129,43,975,113.6,5.94,291.67,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNF20","ENSG00000155827","ATM signaling in development and disease","E3 ubiquitin ligases ubiquitinate target proteins; RHOBTB1 GTPase cycle","",5107.5,5197.6,5023.6,4686.5,4731.9,4688.4,1.0866178013440326,0.11984458703848704,0.001475019369970517,2.8312022764884794,0.03235098663126348,1.490112469802719,356]
["High","Q5VV42","threonylcarbamoyladenosine tRNA methylthiotransferase [OS=Homo sapiens]",23,8,16,8,579,65.1,7.46,36.1,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;ER/Golgi","other molecular function","CDKAL1","ENSG00000145996","Vitamin D receptor pathway","tRNA modification in the nucleus and cytosol","",219.5,220.7,204,231.5,229,241,0.9183178902352103,-0.12293444312444668,0.042501545415035896,1.3715952781139251,0.17392665964392048,0.759633843823366,1908]
["High","Q5VWN6-1","Protein FAM208B [OS=Homo sapiens]",7,12,15,12,2430,268.7,5.9,32.35,"","cytosol;nucleus","","TASOR2","ENSG00000108021","","","",563.2,492.8,516.5,586.1,565.5,566.6,0.9152019555348622,-0.12783796012526252,0.08918051392333858,1.0497300292567977,0.26375812602781346,0.5787941514679934,2640]
["Low","Q5VYS4-1","Mesenteric estrogen-dependent adipogenesis protein [OS=Homo sapiens]",3,1,1,1,303,34.2,6.3,0,"other biological processes","other cell component","","MEDAG","ENSG00000102802","","","",77.5,105.2,88.6,96,88.3,75,1.0462784419591205,0.06526684142857114,0.7128099780721624,0.14702622957815423,0.8512726076456781,0.06993134116386905,6538]
["High","Q5VZL5","Zinc finger MYM-type protein 4 [OS=Homo sapiens]",17,22,51,21,1548,172.7,6.84,94.29,"cell organization and biogenesis;developmental processes;other biological processes","","nucleic acid binding activity;other molecular function","ZMYM4","ENSG00000146463","","","",1956.5,2037.4,2061.3,2135,2278,2168.1,0.9200893467657383,-0.12015413167736477,0.03078171898114628,1.5117071309898926,0.14443729675768638,0.8403206482859623,1664]
["High","Q5XUX0-1","F-box only protein 31 [OS=Homo sapiens]",3,1,1,1,539,60.6,7.02,3.8,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","FBXO31","ENSG00000103264","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",24.3,18.1,15.9,15.5,18.6,14.6,1.1971252566735113,0.2595741111181543,0.3155626986149659,0.5009143386156761,0.5488780465105042,0.2605241393586937,4489]
["High","Q63HQ0","AP-1 complex-associated regulatory protein [OS=Homo sapiens]",7,3,5,3,302,34.3,4.87,9.71,"transport;other biological processes","cytosol;ER/Golgi;other cytoplasmic organelle","cytoskeletal activity;other molecular function","AP1AR","ENSG00000138660","","","",247.4,253.3,221.9,214.3,203.2,210.9,1.1499045194143858,0.20151407413824712,0.03676209833592548,1.4345997075768595,0.15982097093925735,0.7963662352495097,1796]
["High","Q66K64","DDB1- and CUL4-associated factor 15 [OS=Homo sapiens]",12,5,8,5,600,66.4,6.58,21.51,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","DCAF15","ENSG00000132017; ENSG00000288453","","","",306.3,307.1,321.3,352.8,360.3,356.6,0.8737963915116388,-0.1946309469434251,0.001079274340281752,2.9668681481561956,0.029159079754048165,1.535226186254108,289]
["High","Q676U5","Autophagy-related protein 16-1 [OS=Homo sapiens]",21,11,18,11,607,68.2,6.64,40.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","ATG16L1","ENSG00000085978; ENSG00000281089","Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy","Macroautophagy","Autophagy; Autophagy; NOD-like receptor signaling pathway; Shigellosis",658.6,664.7,608.5,732.3,638.1,672.9,0.9454314099740616,-0.08095529888018338,0.3199648989965799,0.49489766233080407,0.5528404362392777,0.25740019900337047,4519]
["High","Q68CP9-1","AT-rich interactive domain-containing protein 2 [OS=Homo sapiens]",10,15,23,15,1835,197.3,7.42,48.14,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;nucleus","nucleic acid binding activity;other molecular function","ARID2","ENSG00000189079","","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Hepatocellular carcinoma",801.2,885.4,882.6,982,1070.8,1038.3,0.8311604283264856,-0.2668011259389644,0.01009176831541722,1.9960327284765829,0.08148555016212787,1.088919397900949,967]
["High","Q68D06","Schlafen family member 13 [OS=Homo sapiens]",3,2,2,2,897,102,6.96,6.51,"RNA metabolism OR transcription;other metabolic processes;stress response","other cell component","nucleic acid binding activity;other molecular function","SLFN13","ENSG00000154760","","","",59.8,54,50,57.1,69.3,71.1,0.829367088607595,-0.2699172963108189,0.09855503264542154,1.0063211938672307,0.2810510207799311,0.5512148330065665,2738]
["High","Q68E01-2","Isoform 2 of Integrator complex subunit 3 [OS=Homo sapiens]",12,10,34,10,1042,117.9,5.8,83.06,"","","","INTS3","","","","",905.5,961.5,919.2,1028.4,1036.5,1046.6,0.8954523541700143,-0.1593114245201755,3.5648782272741336E-3,2.447955300630105,0.04799063654923523,1.3188434895344072,580]
["High","Q69YN2-1","CWF19-like protein 1 [OS=Homo sapiens]",18,6,14,6,538,60.6,7.24,36.93,"RNA metabolism OR transcription;other metabolic processes","nucleus","enzyme regulator activity","CWF19L1","ENSG00000095485","","","",281,288.2,283.6,340,320.1,336.9,0.8553660982948849,-0.22538606652638207,0.00181503635079178,2.7411146726718387,0.03490592075611384,1.4571009015903973,406]
["High","Q6AI39","BRD4-interacting chromatin-remodeling complex-associated protein-like [OS=Homo sapiens]",2,2,2,2,1079,115,6.87,2.43,"other biological processes","nucleus","","BICRAL","ENSG00000112624","","","",55.1,65,62.8,86.5,76.6,92.2,0.7164120642381511,-0.48113846265840265,0.01148829266000652,1.9397445094695525,0.08725738238261763,1.0591978194701739,1028]
["High","Q6DD88","Atlastin-3 [OS=Homo sapiens]",24,9,18,9,541,60.5,5.66,40.43,"cell organization and biogenesis;other biological processes","other membranes;ER/Golgi","other molecular function","ATL3","ENSG00000184743","","","",751.4,793.6,817.5,844.8,854.4,883,0.9149175121989003,-0.1282864171803843,0.031118105311825343,1.506986853766834,0.1451434685034243,0.83820250276544,1674]
["High","Q6F5E8","capping protein, Arp2/3 and myosin-I linker protein 2 [OS=Homo sapiens]",9,9,10,9,1435,154.6,6.76,20.36,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","CARMIL2","ENSG00000159753","","","",242.6,253.8,248.5,312.6,247.3,256.1,0.9128676470588233,-0.1315223899608613,0.31634427102318624,0.4998400261820613,0.5491365202643482,0.26031967262303923,4498]
["High","Q6I9Y2","THO complex subunit 7 homolog [OS=Homo sapiens]",19,3,3,3,204,23.7,5.67,5.61,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","THOC7","ENSG00000163634","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Nucleocytoplasmic transport",193.3,184.2,168.6,190.5,182.9,168.2,1.0083087149187593,0.01193741789926712,0.8850568758453136,0.05302881961619912,0.9421300731561293,0.0258891331368652,7335]
["High","Q6IBS0","Twinfilin-2 [OS=Homo sapiens]",44,13,48,10,349,39.5,6.84,110.24,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","TWF2","ENSG00000247596","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",1830.8,1877.5,1973.7,1661.8,1841.9,1711.5,{"$f":"AVERAGE(T3906:V3906)/AVERAGE(W3906:Y3906)","v":1.0895075931891396},{"$f":"LOG(Z3906,2)","v":0.12367625117446468},{"$f":"TTEST(T3906:V3906,W3906:Y3906,2,2)","v":0.08469963789923747},{"$f":"-LOG10(AB3906)","v":1.0721184463245377},{"$f":"AB3906*7808/AF3906","v":0.25593450956549774},{"$f":"-LOG10(AD3906)","v":0.5918711509889487},2584]
["Medium","Q6IQ26","DENN domain-containing protein 5A [OS=Homo sapiens]",2,1,1,1,1287,147,6.65,0,"transport;other biological processes","other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","DENND5A","ENSG00000184014","","RAB GEFs exchange GTP for GDP on RABs","",13.1,12.2,16.6,10.1,13.1,16.5,1.0554156171284634,0.07781123655639376,0.7642782824407435,0.11674848105371557,0.8801600043211394,0.05543837026214352,6780]
["Medium","Q6IQ55","tau-tubulin kinase 2 [OS=Homo sapiens]",1,1,1,1,1244,137.3,7.01,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","TTBK2","ENSG00000128881","Genes related to primary cilium development (based on CRISPR); Ciliopathies","Anchoring of the basal body to the plasma membrane","",70.6,77.9,76.2,75.8,74,76.2,0.9942477876106194,-0.008322648122642945,0.860135653233873,0.065433050145948,0.931475614486835,0.03082851020674161,7210]
["High","Q6N075","Molybdate-anion transporter [OS=Homo sapiens]",3,1,4,1,450,49.7,7.8,0,"transport","plasma membrane;other membranes","transporter activity","MFSD5","ENSG00000182544","","","",90.3,98.1,94.1,89.5,104.6,101,0.9573026092849881,-0.06295305324209477,0.4548256874024922,0.34215501543961846,0.6708120451905287,0.17339914774631246,5294]
["Medium","Q6NT16","MFS-type transporter SLC18B1 [OS=Homo sapiens]",2,1,1,1,456,48.8,5.22,0,"transport","other membranes","transporter activity","SLC18B1","ENSG00000146409","","","",11.5,12,8.3,15.7,16.9,11.6,0.7194570135746606,-0.47501960410707617,0.10503940180391891,0.9786477602049144,0.29114222551828145,0.5358948025320524,2817]
["High","Q6NUQ4","Transmembrane protein 214 [OS=Homo sapiens]",15,8,20,8,689,77.1,9.14,37.79,"other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi","","TMEM214","ENSG00000119777","","","",851.6,871.8,864.4,829.5,840.5,895.7,1.0086136337062013,0.012373631842920178,0.7470352829798297,0.12665888567914363,0.8717458510695726,0.0596101108999391,6691]
["High","Q6NW29","RWD domain-containing protein 4 [OS=Homo sapiens]",11,2,5,2,188,21.2,5.31,10.8,"","","","RWDD4","ENSG00000182552","","","",184.6,199.2,185.8,199.4,176.3,182,1.021337636722252,0.03045987532575981,0.6605152483473689,0.18011715201360162,0.8165457661647018,0.08801946869122282,6316]
["High","Q6NYC1","Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 [OS=Homo sapiens]",15,5,11,5,403,46.4,8.69,32.12,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","JMJD6","ENSG00000070495","","HDMs demethylate histones","",327.2,313.1,333.2,348.1,391.9,359,0.8858052775250228,-0.17493850222893634,0.04433858368730513,1.3532181837206732,0.1781758422184655,0.7491511796618203,1943]
["High","Q6P1A2","Lysophospholipid acyltransferase 5 [OS=Homo sapiens]",10,4,10,4,487,56,8.69,17.01,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","LPCAT3","ENSG00000111684","Ferroptosis","Acyl chain remodelling of PC; Acyl chain remodelling of PS; Acyl chain remodelling of PE","Glycerophospholipid metabolism; Ferroptosis",317.3,303.2,390.6,275.9,366.4,339.2,1.03015792154865,0.04286551718617006,0.808506797757239,0.0923163242844232,0.9057132104574637,0.043009297723797246,6970]
["High","Q6P1M0","Long-chain fatty acid transport protein 4 [OS=Homo sapiens]",16,7,9,7,643,72,8.47,24.82,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","SLC27A4","ENSG00000167114","PPAR signaling pathway; Fatty acid transporters","Transport of fatty acids; Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)","PPAR signaling pathway; Insulin resistance; Fat digestion and absorption",225.9,221.3,222.2,206,227.2,233.2,1.0045018007202882,0.006480150320982071,0.910656772567837,0.04064527820489789,0.9544171919744524,0.02026174629455536,7450]
["High","Q6P1R4","tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like [OS=Homo sapiens]",16,5,5,5,473,53.2,8.29,5.5,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","DUS1L","ENSG00000169718","","","",242.6,113.4,128.4,125.4,131.7,127.4,1.2598179453836151,0.3332152668451399,0.4606163100354615,0.3366606880978163,0.6751440114054597,0.17060358022401054,5327]
["High","Q6P4A8","Phospholipase B-like 1 [OS=Homo sapiens]",10,4,14,4,553,63.2,9.06,29.02,"other metabolic processes","non-structural extracellular;cytosol;other cytoplasmic organelle","other molecular function","PLBD1","ENSG00000121316","","Acyl chain remodelling of PC; Acyl chain remodelling of PE; Acyl chain remodelling of PI; Hydrolysis of LPC","",487,513.4,511.9,519.8,510.4,542.8,0.9614113159567705,-0.056774310572528665,0.19131100589754263,0.7182600448023938,0.4080186654050841,0.38931996902528954,3661]
["High","Q6P4E1","Protein CASC4 [OS=Homo sapiens]",15,6,10,6,433,48.8,5.82,17.92,"","","","","","","","",263.5,288.9,281,258.9,269,275.2,1.037728800896526,0.053429460340614826,0.31897154010189555,0.4962480646797744,0.5514902092815768,0.2584621932740692,4516]
["High","Q6P9B6","TLD domain-containing protein 1 [OS=Homo sapiens]",12,4,7,4,456,51,6.24,17.31,"signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","","MEAK7","ENSG00000140950","","","",354.5,336.9,329.1,376.7,339.3,361.9,0.9467483068930328,-0.07894715880323874,0.22127685694514532,0.6550640059850995,0.4472507634034933,0.34944890947128443,3863]
["High","Q6PCT2-1","F-box/LRR-repeat protein 19 [OS=Homo sapiens]",2,2,3,2,694,75.7,9.17,1.75,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","FBXL19","ENSG00000099364; ENSGGOG00000003625; ENSPTRG00000008021","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",160,177.4,167,226.8,197.7,210.3,0.794580970384373,-0.3317338525069621,0.011476593028015713,1.9401870186222236,0.0873384389500455,1.0587945747393859,1026]
["High","Q6PD74","Alpha- and gamma-adaptin-binding protein p34 [OS=Homo sapiens]",18,4,21,4,315,34.6,4.64,69.18,"transport","cytosol;nucleus;other cell component","","AAGAB","ENSG00000103591","","","",763.3,806.2,778.9,748.7,774.5,705.7,1.0536138902597694,0.07534627052178701,0.16756457369568184,0.7758177940276496,0.378900721522121,0.4214745677184685,3453]
["High","Q6PIW4","Fidgetin-like protein 1 [OS=Homo sapiens]",16,7,9,6,674,74,7.85,16.75,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","FIGNL1","ENSG00000132436","","","",165.9,149.3,168.3,155.2,195.5,167.6,0.932857418483504,-0.10027150402049537,0.43330070355147293,0.36321060579997927,0.6546462641892222,0.1839933061283716,5168]
["High","Q6PJW8","Consortin [OS=Homo sapiens]",8,4,6,4,725,79.5,4.53,11.79,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","CNST","ENSG00000162852","","","",290.4,297.6,278.8,288.7,252.8,273.5,1.063558282208589,0.08889909408787126,0.2158635045717067,0.6658207763914947,0.4408742463237996,0.35568526975188747,3823]
["High","Q6PL24","Protein TMED8 [OS=Homo sapiens]",13,3,5,3,325,35.7,4.74,10.14,"","","","TMED8","ENSG00000100580","","","",77.5,96,80.9,80.1,76.8,73.4,1.1046461137646548,0.14358425949150982,0.25198778412854034,0.5986205124492472,0.48117403239805406,0.3176978183449477,4089]
["High","Q6RFH5-1","WD repeat-containing protein 74 [OS=Homo sapiens]",48,12,22,12,385,42.4,8.32,50.14,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","","WDR74","ENSG00000133316","","","",696.5,692.5,722.2,802.2,763.2,791.4,{"$f":"AVERAGE(T4034:V4034)/AVERAGE(W4034:Y4034)","v":0.8957909029192124},{"$f":"LOG(Z4034,2)","v":-0.15876607970958106},{"$f":"TTEST(T4034:V4034,W4034:Y4034,2,2)","v":5.336334626323957E-3},{"$f":"-LOG10(AB4034)","v":2.2727569448693563},{"$f":"AB4034*7808/AF4034","v":0.05795007060130383},{"$f":"-LOG10(AD4034)","v":1.2369460305936035},719]
["High","Q6UB35-1","Monofunctional C1-tetrahydrofolate synthase, mitochondrial [OS=Homo sapiens]",22,20,54,19,978,105.7,8.06,110.51,"other metabolic processes;developmental processes","cytosol;mitochondrion","other molecular function","MTHFD1L","ENSG00000120254","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism","Metabolism of folate and pterines","One carbon pool by folate; Metabolic pathways; Biosynthesis of cofactors",1968,1992.2,2007.5,2031.4,2071.1,2039.1,0.9716849029568841,-0.04143954097438007,0.025714641978312122,1.5898195179276025,0.1301230878591452,0.8856456393321154,1543]
["High","Q6ULP2","Aftiphilin [OS=Homo sapiens]",9,6,9,6,937,102.1,4.54,14.03,"","","","","","","","",238.2,233,243.7,237.4,221,212.9,1.0649486071800982,0.09078380983569206,0.1374218513630209,0.861944204890381,0.33901731925512396,0.4697781145851194,3165]
["High","Q6UW68","Transmembrane protein 205 [OS=Homo sapiens]",9,1,5,1,189,21.2,8.62,8.89,"","other membranes","","TMEM205","ENSG00000105518","","","",84.9,69.6,73.8,72,72.3,61.3,1.1104085603112839,0.1510905950308233,0.2636864611255911,0.578912168308173,0.4938507767974611,0.306404258775835,4169]
["High","Q6UWZ7","BRCA1-A complex subunit Abraxas 1 [OS=Homo sapiens]",9,4,5,4,409,46.6,7.05,6.94,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","cytoskeletal activity;other molecular function","ABRAXAS1","ENSG00000163322","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Homologous recombination",350.3,332.5,311.3,396.3,349.7,374.8,0.8869557458957886,-0.1730659709353365,0.07396009769398755,1.1310025238523496,0.23589887369062695,0.6272741326672377,2448]
["Medium","Q6UX68","XK-related protein 5 [OS=Homo sapiens]",1,1,1,1,686,74.9,6.68,0,"","","","","","","","",18.3,15.4,19.4,16.8,22.1,20,0.9015280135823428,-0.14955577302630732,0.37731937557634465,0.42329089294415057,0.6071949061212075,0.21667188048005054,4852]
["High","Q6V1X1","Dipeptidyl peptidase 8 [OS=Homo sapiens]",6,5,5,4,898,103.3,5.8,13.75,"protein metabolism;other biological processes","cytosol;other cell component","other molecular function","DPP8","ENSG00000074603","","","",246.9,251.9,258.6,264.1,260.7,255.7,0.9704035874439463,-0.043343210980851685,0.1389726942720314,0.857070522709373,0.3412260367534658,0.4669578380351703,3180]
["High","Q6VEQ5","WAS protein family homolog 2 [OS=Homo sapiens]",11,4,8,4,465,50.3,5.71,11.75,"cell organization and biogenesis;transport","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity","WASH2P","","","","",294.9,284.2,266.2,332.4,297.9,287.6,0.9209064168210045,-0.11887353884004925,0.2032601166529658,0.6919478295114225,0.42434625423164624,0.3722796270532673,3740]
["High","Q6XZF7","Dynamin-binding protein [OS=Homo sapiens]",5,5,5,5,1577,177.2,5.39,9.6,"signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity","DNMBP","ENSG00000107554","","CDC42 GTPase cycle","",55,67.6,56,58.5,57.1,62.4,1.003370786516854,0.004854839267462807,0.9654804848994447,0.015256500119842115,0.9809331979303663,0.008360567296970628,7685]
["High","Q6Y7W6-1","GRB10-interacting GYF protein 2 [OS=Homo sapiens]",34,41,102,40,1299,150,5.54,190.35,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GIGYF2","ENSG00000204120","VEGFA-VEGFR2 signaling pathway","","",3743,3670.2,3837.5,4138.3,3581,3682.8,0.9867217442400961,-0.019284793186870288,0.7909062574076722,0.10187498844059323,0.8935604193082194,0.048876076750926686,6911]
["High","Q6ZN17-1","Protein lin-28 homolog B [OS=Homo sapiens]",44,9,24,7,250,27.1,8.91,34.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","LIN28B","ENSG00000187772","Cardiac progenitor differentiation; Hippo-Merlin signaling dysregulation; Malignant pleural mesothelioma; CCL18 signaling pathway","","",531.8,569.4,492.6,650.3,559.4,555.2,0.9030539973936199,-0.14711583980258786,0.2090655121414119,0.6797176033468446,0.43230495730936014,0.3642097843142406,3776]
["High","Q6ZPD9-1","probable C-mannosyltransferase DPY19L3 [OS=Homo sapiens]",7,3,4,3,716,83.1,8.72,8.3,"protein metabolism;other metabolic processes","other membranes;nucleus","other molecular function","DPY19L3","ENSG00000178904; ENSPPAG00000028384","","","",25.1,24.3,31.9,23.2,21.1,17.7,1.3112903225806454,0.39098713680079045,0.09038980237095073,1.043880563151171,0.26632587808014463,0.5745866324293435,2650]
["High","Q6ZRS2","Helicase SRCAP [OS=Homo sapiens]",5,14,28,13,3230,343.3,5.96,54.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","SRCAP","ENSG00000080603","Pathways affected in adenoid cystic carcinoma","","",740.2,685.7,713.1,768.7,716.3,751.4,0.9564478626363798,-0.0642417675768555,0.21448371608925848,0.6686056744863932,0.438974798224097,0.357560412118657,3815]
["High","Q6ZTU2","EP400 N-terminal-like protein [OS=Homo sapiens]",5,1,1,1,488,51.7,7.27,0,"","","","EP400P1","","","","",28.9,25.4,19.9,19.4,15,14.8,1.5081300813008127,0.5927608712815631,0.05083484403555149,1.2938385045472527,0.1901861342738793,0.7208211489540712,2087]
["High","Q6ZV29-1","Patatin-like phospholipase domain-containing protein 7 [OS=Homo sapiens]",1,2,4,1,1317,145.6,7.74,0,"","","","","","","","",26.4,27.4,26.4,24.9,30,22.4,1.0375161707632599,0.05313382253007267,0.6910006274751985,0.16052155825692674,0.8367451766945332,0.07740678239532557,6448]
["High","Q6ZW49","PAX-interacting protein 1 [OS=Homo sapiens]",4,4,7,4,1069,121.3,6.7,24.58,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","","PAXIP1","ENSG00000157212","16p11.2 proximal deletion syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nonhomologous End-Joining (NHEJ)","",104.9,112.3,97.1,114,113.2,113.7,0.9219712525667351,-0.1172063273411953,0.11380301597492734,0.9438462282404898,0.3050374008692869,0.5156469082095217,2913]
["Medium","Q70CQ4-1","Ubiquitin carboxyl-terminal hydrolase 31 [OS=Homo sapiens]",1,2,2,2,1352,146.6,9.22,2.03,"protein metabolism;other metabolic processes","nucleus","other molecular function","USP31","ENSG00000103404","","","",64.8,49.5,67.2,52.4,57.8,54.6,1.1013349514563107,0.13925330569989464,0.38861984398505844,0.41047502691386506,0.6182444461767189,0.20883977631019626,4908]
["High","Q70UQ0","Inhibitor of nuclear factor kappa-B kinase-interacting protein [OS=Homo sapiens]",20,8,17,5,350,39.3,9.17,28.46,"other biological processes","other membranes;ER/Golgi","","IKBIP","ENSG00000166130","","","",746.9,791.8,785.4,754.5,775.8,817.2,0.990031948881789,-0.014453012372291064,0.7530007229926152,0.12320460681184589,0.8745247129445693,0.05822791340793414,6723]
["High","Q712K3","Ubiquitin-conjugating enzyme E2 R2 [OS=Homo sapiens]",8,3,8,3,238,27.1,4.42,16.66,"protein metabolism;other metabolic processes","cytosol","other molecular function","UBE2R2","ENSG00000107341","","Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes","Ubiquitin mediated proteolysis",426.3,400.4,397.5,560,518.8,506.6,0.7721710609309953,-0.37300760825027407,0.002916643844236091,2.535116599992586,0.044653245364304706,1.3501469714318872,510]
["High","Q71UM5","40S ribosomal protein S27-like [OS=Homo sapiens]",39,3,17,1,84,9.5,9.45,25.77,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;translational apparatus;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPS27L","ENSG00000185088","","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",193.8,318,174,213.7,186.1,213.2,1.1187601957585644,0.16190083035749056,0.625560967032547,0.20373035766437653,0.7947250293833595,0.09978310892610047,6146]
["High","Q76NI1-1","Protein very KIND [OS=Homo sapiens]",3,4,4,4,1749,191.3,6.16,8.25,"developmental processes;signal transduction;other biological processes","other cell component","enzyme regulator activity","KNDC1","ENSG00000171798","","","",161.7,136.6,170.3,203.9,192.9,184.7,0.805846947549441,-0.31142223749744546,0.031037033514462582,1.5081197948193288,0.14493849143595924,0.838816263263691,1672]
["High","Q7KZF4","staphylococcal nuclease domain-containing protein 1 [OS=Homo sapiens]",55,49,244,49,910,101.9,7.17,624.26,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SND1","ENSG00000197157","VEGFA-VEGFR2 signaling pathway","Signaling by BRAF and RAF1 fusions","Viral carcinogenesis",9303.9,9435.6,9439.9,8292.7,8623.4,8547.3,1.1066628965495575,0.14621582596683746,1.1678851087992433E-3,2.932599879029037,0.02970308446092668,1.5271984498475881,307]
["High","Q7L190","Developmental pluripotency-associated protein 4 [OS=Homo sapiens]",54,15,66,15,304,33.5,9.52,153.1,"developmental processes","nucleus","other molecular function","DPPA4","ENSG00000121570","","POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","",3491.7,3404.8,3493.2,4729.3,4706.9,4642.2,0.7379886918968065,-0.4383293846577726,6.1492607528356434E-6,5.2111770907711525,0.012003356989535176,1.9206972774404794,4]
["Low","Q7L211","Protein Abhd13 [OS=Homo sapiens]",2,1,1,1,337,38.5,8.57,1.73,"protein metabolism;other metabolic processes","other membranes;other cell component","other molecular function","ABHD13","ENSG00000139826","","","",47.9,47.2,48.1,49.1,46.5,37.5,1.0758827948910592,0.10552092135236446,0.3936194350136793,0.4049234663615871,0.6230246398919133,0.2054947771650929,4933]
["High","Q7L3B6","Hsp90 co-chaperone Cdc37-like 1 [OS=Homo sapiens]",15,5,10,5,337,38.8,5.34,21.18,"other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","CDC37L1","ENSG00000106993","","Platelet degranulation","",493.5,513.4,544.7,481.2,445.6,451.5,1.1257346005949356,0.17086674257225246,0.03562155284541958,1.4482871523209107,0.15803016171422507,0.801260015476425,1760]
["High","Q7L5N7","Lysophosphatidylcholine acyltransferase 2 [OS=Homo sapiens]",6,3,4,3,544,60.2,6.55,8.36,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","LPCAT2","ENSG00000087253","","Acyl chain remodelling of PC","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways",135.3,130.1,145.3,107.3,120,121.2,1.1784791965566714,0.23692629122327027,0.030160906227977787,1.5205556136014229,0.14315887892282708,0.8441817112287806,1645]
["High","Q7L7L0","Histone H2A type 3 [OS=Homo sapiens]",35,6,156,1,130,14.1,11.05,351.11,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","H2AW","ENSG00000181218; ENSG00000284841","","HATs acetylate histones; HCMV Early Events; HCMV Late Events; Ub-specific processing proteases; UCH proteinases; RMTs methylate histone arginines; HDACs deacetylate histones; Metalloprotease DUBs","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus",241.5,19.3,20.9,31.1,21.5,32,3.329787234042553,1.735429995254981,0.4240893107583283,0.37254267386704815,0.6477483056340038,0.1885937143587565,5112]
["High","Q7LGA3-1","Heparan sulfate 2-O-sulfotransferase 1 [OS=Homo sapiens]",18,5,8,5,356,41.9,8.69,17.7,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","HS2ST1","ENSG00000153936; ENSGGOG00000040966; ENSPPAG00000039539; ENSPTRG00000000927","Metapathway biotransformation Phase I and II","HS-GAG biosynthesis","Glycosaminoglycan biosynthesis",405.5,386,410.3,410.1,395.9,382,1.0116161616161616,0.016661990845735747,0.697304658018342,0.156577433683787,0.8407280373389768,0.0753444691064877,6476]
["High","Q7RTS7","Keratin, type II cytoskeletal 74 [OS=Homo sapiens]",5,3,14,1,529,57.8,7.71,19.02,"cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","KRT74","ENSG00000170484","","Formation of the cornified envelope","",104.6,105.7,99.3,136.9,105,139.4,0.8119590873328087,-0.3005210595817049,0.10080211674916464,0.9965303480211525,0.28434354319995575,0.5461566291472373,2768]
["High","Q7Z2W9","39S ribosomal protein L21, mitochondrial [OS=Homo sapiens]",42,6,14,6,205,22.8,9.89,31.77,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL21","ENSG00000197345","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",388.9,351.7,396,361.5,394.8,381.2,0.999208791208791,-1.141924809454079E-3,0.9866058707124321,5.856304634643387E-3,0.9924528006342013,0.003290138380004073,7762]
["Low","Q7Z3D4","LysM and putative peptidoglycan-binding domain-containing protein 3 [OS=Homo sapiens]",4,1,1,1,306,34.5,5.97,0,"cell organization and biogenesis","plasma membrane;other membranes;ER/Golgi","","LYSMD3","ENSG00000176018","","","",31.1,37.4,31.2,31.8,29.4,37.3,1.0121827411167512,0.01746978005445723,0.904536073417388,0.0435741085457743,0.9519635612943746,0.0213796749680986,7419]
["High","Q7Z3E2","Coiled-coil domain-containing protein 186 [OS=Homo sapiens]",7,5,7,5,898,103.6,6.27,13.45,"cell-cell signaling;transport;other biological processes","ER/Golgi","other molecular function","CCDC186","ENSG00000165813","","","",223.1,221.8,192.7,234.4,210.7,221.2,0.9569263094702085,-0.06352026427766523,0.4720948045683613,0.32597077897926696,0.6848971077795921,0.1643746677483673,5382]
["High","Q7Z408","CUB and sushi domain-containing protein 2 [OS=Homo sapiens]",0,1,1,1,3487,379.8,6.09,2.32,"","plasma membrane;other membranes","","CSMD2","ENSG00000121904","","","",31.1,28.8,25.1,34.9,34.1,31,0.8499999999999999,-0.2344652536370232,0.07722271253366328,1.1122549473673473,0.2427354828755406,0.6148667342132546,2484]
["High","Q7Z4H8","KDEL motif-containing protein 2 [OS=Homo sapiens]",19,9,16,9,507,58.5,8.24,29.07,"protein metabolism;other metabolic processes","ER/Golgi;other cell component","other molecular function","POGLUT3","ENSG00000178202","","","",847.3,829.9,894,960.6,989.2,964.4,0.8823004598174454,-0.1806580580697848,0.005655088277867604,2.247560611199793,0.059911708648019334,1.2224882944002093,737]
["High","Q7Z4L5","Tetratricopeptide repeat protein 21B [OS=Homo sapiens]",7,7,7,7,1316,150.8,6.96,16,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","TTC21B","ENSG00000123607","Nephrotic syndrome; Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",261.6,234,242.4,201.8,243.8,232.9,1.0876934414148858,0.12127200064154194,0.2566813054973209,0.5906057605260834,0.4853881407902837,0.31391083874215014,4129]
["High","Q7Z4W1","L-xylulose reductase [OS=Homo sapiens]",58,10,24,10,244,25.9,8.1,64.3,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","DCXR","ENSG00000169738","","Formation of xylulose-5-phosphate; Essential pentosuria","Pentose and glucuronate interconversions; Metabolic pathways",731.4,753.5,849.5,408.9,468.6,442.5,1.7684848484848485,0.8225138587847128,1.0890969047961485E-3,2.962933476216797,0.029022759838390196,1.537261291912271,293]
["High","Q7Z624","Calmodulin-lysine N-methyltransferase [OS=Homo sapiens]",7,2,4,2,323,36.1,6.83,7.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","CAMKMT","ENSG00000143919","","Inactivation, recovery and regulation of the phototransduction cascade; Protein methylation","Lysine degradation; Metabolic pathways",194.5,162.4,174.6,158.1,195.6,156.2,1.0423612473033927,0.05985535378990761,0.6737134193993378,0.17152480204165135,0.8251536280266712,0.08346518648900876,6375]
["High","Q7Z628","Neuroepithelial cell-transforming gene 1 protein [OS=Homo sapiens]",10,4,5,4,596,67.7,9.23,11.26,"stress response;signal transduction;other biological processes","cytosol;nucleus","enzyme regulator activity","NET1","ENSG00000173848","Apoptosis-related network due to altered Notch3 in ovarian cancer","RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events","",162.7,148.1,183.4,154.6,186.4,149.8,1.0069274653626732,0.0099597616658794,0.9448202899955522,0.024650788829672293,0.9725981310857312,0.012066569293786215,7585]
["High","Q7Z6M1-1","Rab9 effector protein with Kelch motifs [OS=Homo sapiens]",20,6,9,6,372,40.5,6.25,17.75,"transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","RABEPK","ENSG00000136933","","Retrograde transport at the Trans-Golgi-Network","",540.6,520.8,523,502.2,527.2,513,1.0272302904564314,0.03875964967465789,0.21748055155970591,0.6625795742401587,0.4422104548380687,0.3543709939490541,3840]
["High","Q7Z739","YTH domain-containing family protein 3 [OS=Homo sapiens]",19,10,30,6,585,63.8,9.04,50.5,"cell organization and biogenesis;other biological processes","cytosol;other cell component","translation activity;nucleic acid binding activity","YTHDF3","ENSG00000185728","","","",803.7,749.6,786,777.5,728.7,763.9,1.0304832386238494,0.04332103884037835,0.3450258434540355,0.46214837376983475,0.5779793575818728,0.23808767204378492,4661]
["High","Q7Z7H5","Transmembrane emp24 domain-containing protein 4 [OS=Homo sapiens]",34,7,49,5,227,25.9,8.28,112.09,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED4","ENSG00000158604","","","",748.2,727.4,760.5,756.4,803,753.8,0.9666695486771573,-0.04890529925055556,0.24081632345698087,0.6183140782654558,0.4710154943767802,0.3269648062221539,3992]
["High","Q86SQ9","Dehydrodolichyl diphosphate synthase complex subunit DHDDS [OS=Homo sapiens]",17,4,7,4,333,38.6,8.28,10.61,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DHDDS","ENSG00000117682","","Synthesis of Dolichyl-phosphate; Defective DHDDS causes retinitis pigmentosa 59","Terpenoid backbone biosynthesis",91.2,91.3,86.7,95.7,85.9,95.8,0.9704397981254504,-0.04328937771328589,0.4918877299369272,0.30813401071399227,0.7003390582325907,0.15469165217283196,5484]
["High","Q86TB9","Protein PAT1 homolog 1 [OS=Homo sapiens]",18,8,9,8,770,86.8,6.67,25.84,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","PATL1","ENSG00000166889","","mRNA decay by 5' to 3' exoribonuclease","RNA degradation",335.6,264.7,327.2,320.7,284.6,300.5,1.0239567233384854,0.03415474234541649,0.7840698340507581,0.1056452546724105,0.8899574450164732,0.05063075946337641,6879]
["High","Q86TM6","E3 ubiquitin-protein ligase synoviolin [OS=Homo sapiens]",8,4,9,4,617,67.6,6.95,9.07,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","SYVN1","ENSG00000162298","","Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; XBP1(S) activates chaperone genes; ER Quality Control Compartment (ERQC)","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",284.8,281.5,296.9,265.5,247.9,268.9,1.103413012910648,0.1419728998585739,0.028203667611827073,1.5496944122477245,0.13720513190850206,0.8626296443299799,1605]
["High","Q86U42-1","polyadenylate-binding protein 2 [OS=Homo sapiens]",69,14,44,14,306,32.7,5.06,93.31,"RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BCL2L2; BCL2L2-PABPN1; LOC101332651; LOC102975296; LOC106988220; LOC109255027; LOC110585402; LOC111164107; LOC112822568; LOC116541350; PABPN1","ENSCATG00000038536; ENSCCAG00000033954; ENSCJAG00000007960; ENSDLEG00000019901; ENSFCAG00000031922; ENSG00000100836; ENSGGOG00000022683; ENSMMUG00000014747; ENSMNEG00000045065; ENSOGAG00000008710; ENSPANG00000021100; ENSPTRG00000006167; ENSSSCG00000002023","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA surveillance pathway; Influenza A",1971.1,1997.3,1887.4,2419.8,2286.8,2371.9,0.8272656636292999,-0.2735773917869908,1.3388598747365408E-3,2.8732648739313547,0.03148740331910515,1.5018631529767554,332]
["High","Q86U90","YrdC domain-containing protein, mitochondrial [OS=Homo sapiens]",11,2,4,2,279,29.3,8.57,12.78,"other biological processes","other membranes;mitochondrion;other cell component","nucleic acid binding activity;other molecular function","YRDC","ENSG00000196449","","","",276.3,280.2,290.8,300.9,293.6,284.5,0.9639362912400455,-0.05299029630487263,0.1753548610227669,0.7560821905118621,0.38797697785938334,0.4111940442131959,3529]
["High","Q86UK7-1","E3 ubiquitin-protein ligase ZNF598 [OS=Homo sapiens]",16,12,23,12,904,98.6,8.4,54.84,"protein metabolism;other metabolic processes","","translation activity;other molecular function","ZNF598","","","","",718.2,739.7,694.9,710.9,632.1,664,1.072645739910314,0.10117367939043806,0.13818651114920957,0.8595343478400568,0.340044210227869,0.4684646152818336,3173]
["High","Q86UV5","Ubiquitin carboxyl-terminal hydrolase 48 [OS=Homo sapiens]",22,15,29,15,1035,119,6.05,61.63,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","USP48","ENSG00000090686","","Ub-specific processing proteases","",1266.9,1309.4,1379.9,1417,1478,1527.5,0.8945618993781798,-0.16074678160265393,0.027628024989496243,1.5586501598471771,0.13592918658978365,0.8666872819433901,1587]
["High","Q86V21-1","acetoacetyl-CoA synthetase [OS=Homo sapiens]",19,14,38,14,672,75.1,6.24,75.73,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol","other molecular function","AACS","ENSG00000081760","","Synthesis of Ketone Bodies","Valine, leucine and isoleucine degradation; Butanoate metabolism; Metabolic pathways",1597.2,1549,1750.5,1380.7,1572.8,1473.1,1.1061988885374778,0.1456107976073776,0.12950656613586434,0.8877082117813285,0.3279880857569993,0.4841419318492013,3083]
["Medium","Q86VI4-1","Lysosomal-associated transmembrane protein 4B [OS=Homo sapiens]",2,1,5,1,370,41.1,8.97,1.63,"","","","","","","","",58.9,64.3,61.8,76,61.6,70.6,0.888568683957733,-0.1704447978957425,0.15942369241047977,0.7974471363996196,0.36926140324563217,0.43266608426195613,3371]
["High","Q86VP3-1","Phosphofurin acidic cluster sorting protein 2 [OS=Homo sapiens]",3,2,3,2,889,97.6,6.6,3.91,"cell organization and biogenesis;other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","PACS2","ENSG00000179364","","","",173.5,146.8,161.5,153.2,171.2,157.5,0.999792488068064,-2.9940750151844045E-4,0.9973509710879416,0.001151985134423901,0.9983738951608523,7.0678316626890034E-4,7800]
["High","Q86W42","THO complex subunit 6 homolog [OS=Homo sapiens]",34,8,18,8,341,37.5,7.43,38.82,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity","THOC6","ENSG00000131652","","mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","Nucleocytoplasmic transport",569.3,585.7,567.7,550.4,573.4,574,1.014666038402639,0.02100496482824129,0.43893705434661673,0.35759775517918735,0.6584477464627058,0.1814786843671069,5205]
["High","Q86WA8","Lon protease homolog 2, peroxisomal [OS=Homo sapiens]",4,3,5,3,852,94.6,7.3,4.92,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","LONP2","ENSG00000102910","IL-18 signaling pathway","Peroxisomal protein import; Association of TriC/CCT with target proteins during biosynthesis","",201.5,218.8,211.8,193.3,181.2,184.4,1.1309715512614065,0.17756263987566873,0.016955938694425375,1.7706781623279793,0.10702665264840205,0.9705080572984643,1237]
["High","Q86WP2-1","Vasculin [OS=Homo sapiens]",2,1,1,1,473,53.3,7.05,2.89,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","GPBP1","ENSG00000062194; ENSGGOG00000008390","","","",81.5,50.2,46.9,110.9,60.9,85.7,0.6935922330097087,-0.5278403518367202,0.22117661245654816,0.6552607978829809,0.4471639021389767,0.34953326266772133,3862]
["High","Q86X10-1","Ral GTPase-activating protein subunit beta [OS=Homo sapiens]",12,12,19,12,1494,166.7,6.79,32.52,"other biological processes","","enzyme regulator activity;other molecular function","RALGAPB","ENSG00000170471","","Translocation of SLC2A4 (GLUT4) to the plasma membrane","",348.5,399.1,345.6,370.4,327.4,349.8,1.043528064146621,0.06146940017261079,0.5158534429003565,0.2874736665517192,0.7184772890057052,0.14358695531735116,5606]
["High","Q86X76","Deaminated glutathione amidase [OS=Homo sapiens]",37,9,18,9,327,35.9,7.74,42,"other metabolic processes","mitochondrion;other cell component","other molecular function","NIT1","ENSG00000158793","","","",1077.5,1035.6,1125.2,983.4,1049.6,1021.3,1.0602429361883248,0.08439487108806434,0.12964508258778884,0.8872439512856022,0.32812603074406976,0.48395931499622724,3085]
["High","Q86XP3-1","ATP-dependent RNA helicase DDX42 [OS=Homo sapiens]",43,29,100,29,938,102.9,7.02,237.53,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX42","ENSG00000198231","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",3580.7,3580.2,3739.1,3631.7,3675.6,3742.4,0.98645212087206,-0.01967906589164511,0.46540366148363826,0.33217020429835525,0.6792283717503267,0.16798418166094828,5350]
["High","Q86Y37","CDK2-associated and cullin domain-containing protein 1 [OS=Homo sapiens]",20,6,10,6,369,41,5.19,30.34,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","","other molecular function","CACUL1","ENSG00000151893","","","",243.6,224.4,243.4,237.3,232.2,268.4,0.9640872746984686,-0.052764341507414145,0.533563529528353,0.27281386324797763,0.7315301209055979,0.13576778700446138,5695]
["High","Q86Y91","Kinesin-like protein KIF18B [OS=Homo sapiens]",2,2,2,2,864,94.2,8.79,4.48,"","","","","","","","",175.3,197.3,201,182.2,169.1,175.3,1.0892518040258263,0.12333750265584227,0.1520647949541034,0.8179713193255513,0.3597945209095877,0.44394545454480344,3300]
["Low","Q86YF9","Zinc finger protein DZIP1 [OS=Homo sapiens]",1,1,1,1,867,98.6,6.15,0,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DZIP1","ENSG00000134874","","Hedgehog 'on' state","",74.7,63.9,62.8,64.3,56.6,67.4,1.0695698353690917,0.09703068339255615,0.42940936394554785,0.36712848932329256,0.6520475133580004,0.18572075697149895,5142]
["High","Q86YS3","rab11 family-interacting protein 4 [OS=Homo sapiens]",3,2,2,1,637,71.9,4.87,2.45,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB11FIP4","ENSG00000131242","","","Endocytosis",20.9,22.4,25.4,13.4,20.9,13.9,1.425311203319502,0.5112769525881383,0.0684381670508563,1.1647016304921094,0.22424054063495005,0.6492858681799301,2383]
["High","Q86YZ3","Hornerin [OS=Homo sapiens]",7,5,10,5,2850,282.2,10.04,25.5,"cell organization and biogenesis;developmental processes","non-structural extracellular;plasma membrane;other cytoplasmic organelle;other cell component","other molecular function","HRNR","ENSG00000197915","","Neutrophil degranulation","",330.4,408.4,259.6,404.9,300.6,498.3,0.8293736501079915,-0.26990588253908004,0.39228160438083726,0.4064020571603216,0.6215370874605474,0.2065329516580552,4928]
["High","Q8IUD2-1","ELKS/Rab6-interacting/CAST family member 1 [OS=Homo sapiens]",41,43,115,37,1116,128,5.97,231.63,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","ERC1","ENSG00000082805","","","NF-kappa B signaling pathway",4324.7,4235.7,4240.4,4746.3,4404.1,4335.1,0.9492269474620889,-0.0751750373200202,0.15492955751942114,0.8098657194711792,0.3631612083793576,0.43990054750372065,3331]
["Low","Q8IUM7","Neuronal pas domain-containing protein 4 [OS=Homo sapiens]",2,1,1,1,802,87.1,4.64,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NPAS4","ENSG00000174576","Orexin receptor pathway","","",23.7,22.2,19.6,26.7,17.4,19.7,1.0266457680250785,0.037938482659943366,0.8613034107594432,0.06484383297531846,0.9315773696093271,0.030781070130023562,7219]
["High","Q8IV08","Phospholipase D3 [OS=Homo sapiens]",12,5,19,5,490,54.7,6.47,34.28,"DNA metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","PLD3","ENSG00000105223","","Role of phospholipids in phagocytosis; Synthesis of PG","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways",582.3,547,639.6,480.3,546.2,514.8,1.1476675533640435,0.1987047948251395,0.083144602956798,1.0801659362478635,0.25339307567786057,0.5962052569978956,2562]
["High","Q8IVD9","NudC domain-containing protein 3 [OS=Homo sapiens]",56,15,49,15,361,40.8,5.25,78.44,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","other molecular function","NUDCD3","ENSG00000015676","","","",1171.8,1157.8,1208.5,1055.4,1010.5,1009.6,1.1504145667371157,0.20215384864571445,1.9594507611196852E-3,2.707865645399808,0.03660141517421651,1.4365021225162076,418]
["High","Q8IVL5","Prolyl 3-hydroxylase 2 [OS=Homo sapiens]",8,5,9,4,708,80.9,5.71,16.09,"protein metabolism;other metabolic processes;other biological processes","extracellular matrix;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","P3H2","ENSG00000090530","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",125,118.5,124.5,123.7,137,138.5,0.9218436873747495,-0.11740595439288527,0.11337463804203869,0.9454840864508888,0.3048309827245999,0.5159408938203095,2904]
["Medium","Q8IVV7","Glucose-induced degradation protein 4 homolog [OS=Homo sapiens]",4,1,1,1,300,33.5,9.16,2.55,"protein metabolism;other metabolic processes","other cell component","other molecular function","GID4","ENSG00000141034","Ciliary landscape","","",28,35,36.8,29.1,39.1,41.4,0.9105839416058394,-0.13513607762326615,0.5195947215510355,0.28433526947911414,0.7212436597103085,0.14191799160387886,5625]
["Medium","Q8IWB1","Inositol 1,4,5-trisphosphate receptor-interacting protein [OS=Homo sapiens]",1,1,1,1,547,62,5.88,2.41,"other biological processes","plasma membrane;other membranes;nucleus","enzyme regulator activity","ITPRIP","ENSG00000148841","","","",72.4,76.8,77.6,83.1,68.2,91.6,{"$f":"AVERAGE(T4482:V4482)/AVERAGE(W4482:Y4482)","v":0.9337175792507204},{"$f":"LOG(Z4482,2)","v":-0.09894184969363627},{"$f":"TTEST(T4482:V4482,W4482:Y4482,2,2)","v":0.4876050150613812},{"$f":"-LOG10(AB4482)","v":0.3119318362729262},{"$f":"AB4482*7808/AF4482","v":0.6971653465664283},{"$f":"-LOG10(AD4482)","v":0.15666420814983417},5461]
["Medium","Q8IWE2","Protein Noxp20 [OS=Homo sapiens]",4,1,1,1,563,60.7,4.68,0,"","cytosol;ER/Golgi;nucleus","","FAM114A1","ENSG00000197712","","","",27.3,28.4,29.4,26.3,33.9,29.3,0.9508379888268156,-0.07272855046565621,0.5570088592336797,0.25413789731154324,0.7507552516652116,0.12450162115196499,5793]
["High","Q8IWR0","Zinc finger CCCH domain-containing protein 7A [OS=Homo sapiens]",19,17,27,17,971,110.5,7.3,67.19,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZC3H7A","ENSG00000122299","","","",1274.7,1262.3,1229.3,1347.5,1298.3,1384.9,0.9344034534944302,-0.09788248855247905,0.036498188773438744,1.437728686919372,0.15974095176177674,0.7965837323008408,1784]
["Low","Q8IWV2","Contactin-4 [OS=Homo sapiens]",1,1,2,1,1026,113.4,7.47,4.22,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","other molecular function","CNTN4","ENSG00000144619","","Post-translational modification: synthesis of GPI-anchored proteins","",182.1,162.8,177.7,180,196.6,173.2,0.9505274645325572,-0.07319978219293259,0.37441391335456115,0.42664802109622224,0.6051384465891976,0.21814525392410658,4831]
["High","Q8IWZ6-1","Bardet-Biedl syndrome 7 protein [OS=Homo sapiens]",2,1,1,1,715,80.3,6.05,2.13,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BBS7","ENSG00000138686; ENSGGOG00000002169","Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","BBSome-mediated cargo-targeting to cilium","",33.2,31.3,29.2,35.3,27.4,37.7,0.9332669322709163,-0.09963831629158525,0.5378858804015646,0.2693098558746343,0.7350040171815568,0.13371028726272313,5714]
["Medium","Q8IX21","SMC5-SMC6 complex localization factor protein 2 [OS=Homo sapiens]",1,1,1,1,1173,131.8,8.97,2.07,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","SLF2","ENSG00000119906","","","",76.9,68.5,70.2,73.5,93.5,64.2,0.9325259515570936,-0.10078421974817305,0.5950251988940569,0.22546464181950776,0.775877881256646,0.11020662883188709,5988]
["High","Q8IXI1","Mitochondrial Rho GTPase 2 [OS=Homo sapiens]",27,10,32,9,618,68.1,5.86,88.53,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion","other molecular function","RHOT2","ENSG00000140983","","RHOT2 GTPase cycle","Mitophagy",962.5,1002.6,1015.4,965.8,941.3,985.4,1.0304235090751945,0.043237413975974144,0.22405843119266464,0.6496387091865242,0.4508887192660633,0.34593063012209607,3880]
["Medium","Q8IXQ4","GPALPP motifs-containing protein 1 [OS=Homo sapiens]",2,1,2,1,340,38.1,5.41,2.83,"","","","GPALPP1","ENSG00000133114","","","",135.3,135.2,138.3,237,157.6,103.5,0.8207187311784783,-0.2850402147349659,0.48555562987491296,0.3137610059955943,0.6953812102097067,0.1577770484995948,5452]
["High","Q8IXU6-1","Solute carrier family 35 member f2 [OS=Homo sapiens]",10,2,5,2,374,41.2,6.21,10.53,"transport","other membranes","transporter activity","SLC35F2","ENSG00000110660","","","",203.5,172.9,180.1,197.6,187.2,176.1,0.9921554644321626,-0.011361895452463126,0.9015150730588339,0.04502700760874298,0.9500647442898333,0.022246797732517955,7409]
["Medium","Q8IY26","Phospholipid phosphatase 6 [OS=Homo sapiens]",3,1,2,1,295,32.2,9.99,1.67,"other metabolic processes","plasma membrane;other membranes","other molecular function","PLPP6","ENSG00000205808","","Cholesterol biosynthesis","",30.7,30.9,35.5,31.4,28.7,31.1,1.0646929824561406,0.09043747125445097,0.3325008732180583,0.47820720980963977,0.5649982193877257,0.24795292087313442,4595]
["High","Q8IY67-2","Isoform 2 of Ribonucleoprotein PTB-binding 1 [OS=Homo sapiens]",24,11,49,11,739,77.8,8.84,96.33,"","","","RAVER1","","","","",1539.9,1503.5,1562.8,1538,1517.6,1585.7,0.992437463641652,-0.010951898159771083,0.6822924026394686,0.1660294645842676,0.8305798378249096,0.08061861551805385,6414]
["High","Q8IYB7","DIS3-like exonuclease 2 [OS=Homo sapiens]",20,15,30,15,885,99.2,6.1,63.11,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","other cell component","nucleic acid binding activity;other molecular function","DIS3L2","ENSG00000144535","","","",1600,1674,1639.4,1630.2,1574,1626.4,1.0171407278598932,0.024519298998631193,0.38056662555263276,0.41956930058358216,0.6100316592722145,0.21464762549671668,4871]
["High","Q8IYS1","Peptidase M20 domain-containing protein 2 [OS=Homo sapiens]",6,2,2,2,436,47.7,5.85,0,"protein metabolism;other biological processes","nucleus","other molecular function","PM20D2","ENSG00000146281","","","",36.3,42.1,38,37.3,43.1,43.6,0.9387096774193548,-0.09124906236595368,0.39409180809486966,0.4044025926303896,0.6235195212978202,0.20514994497740968,4935]
["High","Q8IYS2-1","Uncharacterized protein KIAA2013 [OS=Homo sapiens]",10,5,6,5,634,69.1,8.19,19.27,"","other membranes","","KIAA2013","ENSG00000116685","","","",188,183.5,200,172.1,161.6,162.7,1.1512892828364223,0.20325038297148398,0.013582464733610916,1.867021413923033,0.09571469732855058,1.0190213696568085,1108]
["High","Q8IZ40","REST corepressor 2 [OS=Homo sapiens]",37,15,40,15,523,58,9.01,101.75,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","RCOR2","ENSG00000167771","","","",1359.4,1292.7,1413,1526.5,1500.2,1435.3,0.9110488570147918,-0.13439967106536999,0.03995631389662865,1.3984145837141662,0.16800156106886185,0.7746866827953113,1857]
["Medium","Q8IZE3","Protein-associating with the carboxyl-terminal domain of ezrin [OS=Homo sapiens]",1,1,1,1,742,82.8,5.05,2.05,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","SCYL3","ENSG00000000457","","","",120.1,142.9,148.7,124.2,128.2,132.2,1.0704628185127405,0.09823468598137208,0.3736991896930697,0.42747784384747245,0.604609049549003,0.21852535676160403,4826]
["High","Q8IZQ5","Selenoprotein H [OS=Homo sapiens]",34,4,10,4,122,13.4,9.74,17.95,"","ER/Golgi","","SELENOH","ENSG00000211450","Selenium micronutrient network","","",398.5,423.3,409.8,422.3,346.6,368.4,1.0829156774817548,0.11492091015301656,0.2539226537551654,0.5952985517376117,0.4825086591677613,0.31649488834084766,4109]
["High","Q8IZT6-1","Abnormal spindle-like microcephaly-associated protein [OS=Homo sapiens]",3,9,12,9,3477,409.5,10.45,16.43,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","ASPM","ENSG00000066279","","","",359,337.3,417.2,274.1,273.4,294.6,1.3222895143094646,0.40303808844147165,0.021944952783203495,1.6586653492467243,0.12058141543367551,0.9187196225155586,1421]
["Medium","Q8N0Z8","tRNA pseudouridine synthase-like 1 [OS=Homo sapiens]",4,1,1,1,303,33.2,9.85,2.27,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","PUSL1","ENSG00000169972","","","",96.1,88.6,76.2,92.4,78.3,77.2,1.052440500201694,0.07373867273072969,0.5986173513457214,0.22285069898181625,0.7784817254009648,0.10875157789441359,6004]
["Medium","Q8N118","Cytochrome P450 4X1 [OS=Homo sapiens]",1,1,1,1,509,58.8,8.48,0,"","other membranes;ER/Golgi","other molecular function","CYP4X1","ENSG00000186377","Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II","","Serotonergic synapse",19.9,27.1,17.8,25.4,23.9,28.8,0.8297055057618438,-0.2693287352573546,0.23416501737496756,0.6304779849929639,0.4633452751301943,0.3340952612505009,3946]
["High","Q8N1G1","RNA exonuclease 1 homolog [OS=Homo sapiens]",6,6,6,6,1221,131.4,8.95,10.33,"other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","REXO1","ENSG00000079313","","","Ribosome biogenesis in eukaryotes",362.4,332.1,324.4,321.6,303.7,325.8,1.0712858795079383,0.09934352389094767,0.1677679876350667,0.7752909047694035,0.37903137947181736,0.42132483391762376,3456]
["High","Q8N257","Histone H2B type 3-B [OS=Homo sapiens]",58,9,328,1,126,13.9,10.32,686.55,"cell organization and biogenesis","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","H2BU1","ENSG00000196890; ENSG00000285449","","Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Assembly of the ORC complex at the origin of replication; HATs acetylate histones; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Amyloid fiber formation; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Meiotic synapsis; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; HCMV Early Events; HCMV Late Events; HDACs deacetylate histones","Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis; Systemic lupus erythematosus",875.8,824.7,828.9,789.6,788.5,748.9,1.0869789428448646,0.1203239924833993,0.03323477746855903,1.4784072248031972,0.1513985662044976,0.8198782377317413,1714]
["High","Q8N2F6-1","Armadillo repeat-containing protein 10 [OS=Homo sapiens]",17,4,6,4,343,37.5,6.61,13.58,"other biological processes","other membranes;mitochondrion;ER/Golgi","other molecular function","ARMC10","ENSG00000170632","","","",317.5,304.1,328.5,278.3,306.4,278.9,1.10016211208893,0.13771612472684078,0.0685482141785894,1.1640038549880618,0.22441276993980128,0.6489524337055592,2385]
["High","Q8N339","Metallothionein-1M [OS=Homo sapiens]",36,2,12,1,61,6.1,7.69,19.87,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1M","ENSG00000205364","Zinc homeostasis","Metallothioneins bind metals","Mineral absorption",16.1,16.7,17.2,10.7,12.8,16.8,1.240694789081886,0.31114825613411984,0.1498077650037462,0.8244656752154639,0.3569420290354747,0.4474023119392042,3277]
["High","Q8N3P4-1","Vacuolar protein sorting-associated protein 8 homolog [OS=Homo sapiens]",4,4,5,3,1428,161.7,5.64,6.06,"cell organization and biogenesis;transport","other cytoplasmic organelle","other molecular function","VPS8","ENSG00000156931","","","",18.3,13.8,20,17,15.7,17.2,1.0440881763527052,0.06224355694124745,0.7203440258064351,0.14246004131036638,0.8556893585115845,0.06768386893209877,6573]
["High","Q8N3X1","Formin-binding protein 4 [OS=Homo sapiens]",13,10,17,10,1017,110.2,4.74,30.6,"","nucleus","","FNBP4","ENSG00000109920; ENSG00000285182","","","",567.8,541.4,532.5,678.2,642.6,689.9,0.8164818222509571,-0.2925073281944842,0.002271235203037538,2.64373788907745,0.03958438496722566,1.4024760984169586,448]
["High","Q8N488","RING1 and YY1-binding protein [OS=Homo sapiens]",41,8,28,8,228,24.8,9.63,46.92,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RYBP","ENSG00000163602","","Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",604.2,712.8,582,602.2,531.6,574.6,1.1115663778974478,0.152594102394718,0.23368644956241863,0.6313664696825899,0.463220055390547,0.33421264583309623,3939]
["High","Q8N4C6","ninein [OS=Homo sapiens]",3,6,8,5,2090,243.1,5.03,7.68,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","NIN","ENSG00000100503","","","",79.3,94.5,91.1,97.9,89,88,0.9636231356857039,-0.05345906314333104,0.5823042095915006,0.2348500702805175,0.7669755851029751,0.11521846059315387,5928]
["High","Q8N4V1","Membrane magnesium transporter 1 [OS=Homo sapiens]",25,2,6,2,131,14.7,9.16,13.27,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity","MMGT1","ENSG00000169446","","Miscellaneous transport and binding events","",413.1,395.2,456,371.6,479.1,434,0.9841208064139487,-0.023092669448329,0.8594166057563205,0.06579625907815258,0.9317307494786657,0.030709571454783684,7202]
["High","Q8N5A5-1","Zinc finger CCCH-type with G patch domain-containing protein [OS=Homo sapiens]",24,8,18,8,531,57.3,5.43,53.91,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZGPAT","ENSG00000197114","","","",824.1,777.7,841.8,710.7,775.6,706.9,1.1141710742294364,0.15597076678344612,0.04675342871133005,1.330186534185943,0.18270809378281533,0.738242213417271,1998]
["High","Q8N5D0-1","WD and tetratricopeptide repeats protein 1 [OS=Homo sapiens]",4,2,2,2,677,75.9,7.27,4.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","WDTC1","ENSCATG00000044454; ENSCSAG00000000989; ENSG00000142784; ENSMFAG00000040733; ENSMNEG00000041566; ENSPANG00000008666; ENSPPAG00000030849; ENSPPYG00000001668","","Neddylation","",64,54.3,62.3,56.3,67.2,78.1,0.8958333333333333,-0.15869774601905837,0.3719057404037311,0.42956711820885707,0.6030820396827274,0.21962360501077494,4815]
["High","Q8N5N7","39S ribosomal protein L50, mitochondrial [OS=Homo sapiens]",21,2,2,2,158,18.3,7.88,4.88,"","other membranes;mitochondrion;translational apparatus","","MRPL50","ENSG00000136897","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",28.2,31.5,32.2,34.9,25.9,20.6,1.128992628992629,0.1750360670227876,0.46636850986707684,0.33127078168958185,0.6800009944056277,0.1674904521988209,5355]
["High","Q8N653","Leucine-zipper-like transcriptional regulator 1 [OS=Homo sapiens]",1,1,1,1,840,94.7,6.57,2.7,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LZTR1","ENSG00000099949","22q11.2 copy number variation syndrome","","",25.8,27.3,29.5,28.8,26.1,33.9,0.93018018018018,-0.10441789493066087,0.4593269240838123,0.3378780970634108,0.6740132725514765,0.17133155132949787,5321]
["High","Q8N6G5-1","chondroitin sulfate N-acetylgalactosaminyltransferase 2 [OS=Homo sapiens]",4,2,2,2,542,62.5,5.73,4.97,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CSGALNACT2","ENSG00000169826; ENSPPAG00000040591; ENSPTRG00000002443","","Chondroitin sulfate biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",87.6,81.8,89.2,59.1,65,70.9,1.326153846153846,0.40724815117328117,6.5408974163469495E-3,2.1843626620381635,0.06440268225326228,1.1910960446971317,793]
["High","Q8N720-1","zinc finger protein 655 [OS=Homo sapiens]",13,6,6,6,491,57.4,7.14,15.03,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF655","ENSG00000197343; ENSPPAG00000041610; ENSPTRG00000048790","Retinoblastoma gene in cancer","Generic Transcription Pathway","",351.5,308.5,284.6,428.1,373.7,403.3,0.7838353663596382,-0.35137742661605764,0.02585192772192085,1.5875070669693407,0.13031107272611878,0.8850186800699115,1549]
["High","Q8N8A6","ATP-dependent RNA helicase DDX51 [OS=Homo sapiens]",22,9,22,9,666,72.4,8.16,67.05,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DDX51","ENSG00000185163; ENSG00000288503","","","",454,528.3,459.1,477.6,513.7,495.3,0.9695950491053411,-0.04454576267035983,0.5951034865859037,0.22540750528791437,0.7757208719971179,0.11029452301859036,5990]
["Low","Q8N8K9","Uncharacterized protein KIAA1958 [OS=Homo sapiens]",1,1,1,1,716,79.2,6.83,2.28,"","","","KIAA1958","ENSG00000165185","","","",59.4,57.9,67.7,63.5,56.4,57,1.0457885811192764,0.06459122271321606,0.5168236914996301,0.2866575862441548,0.7191872007180738,0.14315805028897657,5611]
["High","Q8N983","39S ribosomal protein L43, mitochondrial [OS=Homo sapiens]",10,2,5,2,215,23.4,8.65,3.24,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL43","ENSG00000055950","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",154.4,155.8,140.8,156.8,149.8,133.1,1.0256993404594041,0.03660790093009611,0.6806912410364974,0.1670498377514917,0.8294065558696897,0.08123253616903753,6408]
["High","Q8N9N8","probable RNA-binding protein EIF1AD [OS=Homo sapiens]",27,4,8,4,165,19,5.21,14.52,"protein metabolism;other metabolic processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity","EIF1AD","ENSG00000175376","","","",135.2,163.6,131.2,172,141.2,133.1,0.9634774815146762,-0.053677146775032575,0.7457123598247395,0.1274286586269332,0.8707226118605602,0.06012017716819796,6687]
["Medium","Q8N9V7","Testis- and ovary-specific PAZ domain-containing protein 1 [OS=Homo sapiens]",1,1,6,1,1692,190.8,7.87,1.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol","","TOPAZ1","ENSG00000173769","","","",214.5,173.3,328.4,217.6,333.9,242.4,0.9021287315782845,-0.14859477763947665,0.6799791110218163,0.1675044286280312,0.8289269162932619,0.08148375805010086,6405]
["High","Q8NB49-1","Phospholipid-transporting ATPase IG [OS=Homo sapiens]",18,14,19,14,1132,129.4,6.67,40.15,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","ATP11C","ENSG00000101974","Complement system in neuronal development and plasticity","Ion transport by P-type ATPases","",635.5,572.6,629.6,642.1,697.6,686.1,0.9071477934643102,-0.14059047960433943,0.07517106544534799,1.1239492941897675,0.23859173942978745,0.6223445966345112,2460]
["High","Q8NB90-1","Spermatogenesis-associated protein 5 [OS=Homo sapiens]",19,11,21,10,893,97.8,5.66,36.87,"developmental processes;other biological processes","cytoskeleton;mitochondrion;other cell component","other molecular function","SPATA5","ENSG00000145375","","","Ribosome biogenesis in eukaryotes",627.5,577.2,651.3,614.9,598.4,608.2,1.018940433708482,0.027069715384789982,0.6341645367533175,0.1977980479017582,0.799670010169558,0.09708919091795899,6192]
["High","Q8NBJ7-1","Sulfatase-modifying factor 2 [OS=Homo sapiens]",25,7,25,7,301,33.8,8,50.27,"","ER/Golgi","other molecular function","SUMF2","ENSG00000129103","","Glycosphingolipid metabolism; The activation of arylsulfatases","",927.2,945.4,968.2,961.7,921.2,888,1.0252264607167347,0.0359426196494333,0.39349007882641485,0.40506621315309943,0.6229461750763681,0.20554947641815804,4932]
["High","Q8NBN3-1","Transmembrane protein 87A [OS=Homo sapiens]",14,5,10,5,555,63.4,6.74,24.09,"transport","other membranes;cytosol;ER/Golgi","","TMEM87A","ENSG00000103978","","RHOA GTPase cycle","",199,208.2,216.1,228.6,225.7,230.9,0.9096614127262114,-0.13659843867311447,0.0162000955523478,1.7904824238687889,0.10479730411991021,0.9796498893075026,1207]
["High","Q8NBT2","kinetochore protein SPC24 [OS=Homo sapiens]",49,8,16,8,197,22.5,4.7,36.98,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","","SPC24","ENSG00000161888","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",609,550.6,508.5,590.9,533.3,533.5,1.0062737527900103,0.009022838012753906,0.9256061721285824,0.03357375808348081,0.9633608360410519,0.01621101323954936,7502]
["High","Q8NC54","Keratinocyte-associated transmembrane protein 2 [OS=Homo sapiens]",5,1,1,1,265,29.2,5.08,2.85,"","other membranes","","KCT2","ENSG00000113583","","","",33.6,23.1,29.5,31.9,30.9,37.9,0.8560079443892752,-0.22430390891768634,0.2676426841806999,0.5724446232440308,0.4982723123707451,0.3025332447147204,4194]
["High","Q8NC96","adaptin ear-binding coat-associated protein 1 [OS=Homo sapiens]",27,6,17,6,275,29.7,6.8,34.83,"transport","plasma membrane;other membranes;cytosol","","NECAP1","ENSG00000089818","","Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",719.1,718.2,697.1,911.2,894.2,878.3,0.7953198941759512,-0.3303928358558951,1.0452491328170097E-4,3.9807801840865107,0.010738559511888436,1.9690539717086668,76]
["High","Q8NCH0","Carbohydrate sulfotransferase 14 [OS=Homo sapiens]",12,4,7,4,376,43,9.48,6.95,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST14","ENSG00000169105","Proteoglycan biosynthesis; Metapathway biotransformation Phase I and II","Dermatan sulfate biosynthesis; Defective CHST14 causes EDS, musculocontractural type","Glycosaminoglycan biosynthesis",51.8,44.3,44.7,48,45.2,47,1.0042796005706136,0.006160984626674369,0.9417106491731506,0.026082518407961875,0.970933150500985,0.012810670573939293,7573]
["High","Q8ND30","Liprin-beta-2 [OS=Homo sapiens]",13,8,17,6,876,98.5,6.27,36.09,"cell organization and biogenesis","cytosol;other cell component","other molecular function","PPFIBP2","ENSG00000166387","Ectoderm differentiation","Receptor-type tyrosine-protein phosphatases","",96.3,91.7,86.7,106,89.2,94.8,0.9472413793103447,-0.07819598982644091,0.4187697035027378,0.37802474551641235,0.6427666296342396,0.19194667848913163,5087]
["High","Q8ND76","cyclin-Y [OS=Homo sapiens]",7,2,3,1,341,39.3,7.2,7.6,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","enzyme regulator activity;other molecular function","CCNY","ENSG00000108100","","","",81.1,70.5,94,67.6,67.7,71.2,1.1893462469733656,0.2501687790633716,0.13179543438917252,0.8800996341572788,0.3314198878295198,0.47962143401124235,3105]
["High","Q8NDX6","Zinc finger protein 740 [OS=Homo sapiens]",14,3,3,3,193,21.8,9.19,4.23,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF740","ENSG00000139651","","Generic Transcription Pathway","",178.4,201.8,174.4,208,217.9,205.1,0.8789223454833598,-0.18619238883043265,0.05330206315009181,1.2732559805164094,0.19520755585174338,0.7095033762123086,2132]
["High","Q8NE62","Choline dehydrogenase, mitochondrial [OS=Homo sapiens]",5,4,6,4,594,65.3,8.28,8.09,"other metabolic processes","other membranes;mitochondrion","other molecular function","CHDH","ENSG00000016391","Methionine de novo and salvage pathway; One-carbon metabolism and related pathways","Choline catabolism","Glycine, serine and threonine metabolism; Metabolic pathways",337.6,336.7,352.6,344.8,368.3,343.6,0.9717989968770702,-0.041270151628730115,0.35711053652133046,0.4471973357899539,0.5904953556032504,0.22878351387402668,4722]
["Medium","Q8NEE8","Tetratricopeptide repeat protein 16 [OS=Homo sapiens]",1,1,2,1,873,98.2,9.01,0,"","","","TTC16","ENSG00000167094","","","",116.7,103.1,97.1,114.6,99.5,97.3,1.0176621708413616,0.025258715303196625,0.8289055380989462,0.08149495873784258,0.9172469446537092,0.0375137262029705,7056]
["High","Q8NEN9","PDZ domain-containing protein 8 [OS=Homo sapiens]",9,7,10,7,1154,128.5,6.09,18.93,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PDZD8","ENSG00000165650","","","",196.1,200.7,203.5,171.7,191.7,175.9,1.1131095865010199,0.15459563411633734,0.034585627242575724,1.4611043435787872,0.1551088900115056,0.8093633100374831,1741]
["High","Q8NEY1","neuron navigator 1 [OS=Homo sapiens]",17,24,41,24,1877,202.3,8.07,87.32,"cell organization and biogenesis;developmental processes","cytoskeleton;other cell component","","NAV1","ENSG00000134369","","","",1428.2,1429.8,1430.9,2029.8,1783.8,1879.4,0.7533637800808008,-0.40858142124357577,0.002830590266141791,2.5481229911195364,0.04393886440961253,1.3571511715168285,503]
["High","Q8NF99-1","Zinc finger protein 397 [OS=Homo sapiens]",11,4,7,2,534,61.1,7.27,9.32,"other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF397","ENSG00000186812","","","",58.5,50.4,52.3,49.7,48.6,51.5,1.076101468624833,0.10581412006921606,0.21587521596855663,0.6657972149420043,0.4407828677516972,0.3557752938874313,3824]
["High","Q8NFH3","Nucleoporin Nup43 [OS=Homo sapiens]",20,5,11,5,380,42.1,5.63,29.01,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;nucleus;other cell component","","NUP43","ENSG00000120253","","Separation of Sister Chromatids; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Transport of Ribonucleoproteins into the Host Nucleus; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transport of Mature mRNA derived from an Intron-Containing Transcript; tRNA processing in the nucleus; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis",254.9,216.9,271.4,264.5,251.8,237.5,0.9859379145661981,-0.020431293281703546,0.8533187155344908,0.06888872903720805,0.9291190253651239,0.03192864688029054,7171]
["High","Q8NFP7","Diphosphoinositol polyphosphate phosphohydrolase 3-alpha [OS=Homo sapiens]",27,4,6,1,164,18.5,5.68,15.96,"other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT10","ENSG00000122824","","Synthesis of pyrophosphates in the cytosol","",50.5,44.1,48.5,57.4,62.3,59.4,0.7989949748743719,-0.32374166525929343,0.007118278249532277,2.1476250396709475,0.06680230357253368,1.175208561303036,832]
["High","Q8NFY9","Kelch repeat and BTB domain-containing protein 8 [OS=Homo sapiens]",5,3,4,3,601,68.8,6.29,7.76,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","","KBTBD8","ENSG00000163376","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",219.2,219.2,219.2,183.9,199.4,193,1.1410723581467983,0.1903902792949993,0.003821024144546529,2.417820218053492,0.04882906140854222,1.311321623637411,611]
["High","Q8NG48-1","protein Lines homolog 1 [OS=Homo sapiens]",2,2,7,1,757,85.8,6.52,9.69,"other biological processes","","","LINS1","ENSG00000140471","","","",82.2,88,88.2,93.4,65.3,84.2,1.0638122684232194,0.08924358005805985,0.5762016379207422,0.23942551152084518,0.7622809876118528,0.11788491202615044,5902]
["High","Q8NHP6-1","motile sperm domain-containing protein 2 [OS=Homo sapiens]",20,7,12,7,518,59.7,5.96,23.2,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","MOSPD2","ENSG00000130150","","Neutrophil degranulation; RHOD GTPase cycle","",495,449.5,508.6,507.4,459.3,461.2,1.0176482946985081,0.02523904356974804,0.7419914687431768,0.12960108811593524,0.869107318923901,0.06092659278181108,6666]
["High","Q8NI36","WD repeat-containing protein 36 [OS=Homo sapiens]",15,13,37,13,951,105.3,7.53,67.35,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","WDR36","ENSG00000134987","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1454.9,1503.3,1561.9,1453,1615.3,1614,0.9653589048117378,-0.05086268211585728,0.4333098405050894,0.3632014479872469,0.6545334174238224,0.18406817549630244,5169]
["Medium","Q8TAD4-1","Zinc transporter 5 [OS=Homo sapiens]",1,1,1,1,765,84,7.31,2.25,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A5","ENSG00000145740","Zinc homeostasis","Insulin processing; Zinc efflux and compartmentalization by the SLC30 family","",67.3,65,53.1,50.5,69.4,57.8,1.043331457512662,0.061197562596852856,0.7340897288262958,0.13425085241032034,0.8634788494540099,0.06374829582427005,6638]
["High","Q8TAD7","Overexpressed in colon carcinoma 1 protein [OS=Homo sapiens]",19,1,1,1,63,6.4,6.57,2.01,"","","","OCC1","ENSG00000235162","","","",19.8,14.1,17.1,15.8,15,13.5,1.1512415349887133,0.2031905483038396,0.2776476406051973,0.5565060127244496,0.5087708936506408,0.2934777422662675,4261]
["High","Q8TB52","F-box only protein 30 [OS=Homo sapiens]",5,3,4,3,745,82.3,5.4,12.41,"protein metabolism;other metabolic processes","cytosol","other molecular function","FBXO30","ENSG00000118496","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",153.9,131.5,136.4,163.7,138,148.4,0.9371250833148189,-0.09368646959185999,0.40301667277864084,0.3946769867472729,0.6293508362111255,0.20110718642465633,5000]
["Medium","Q8TBC5","Zinc finger and SCAN domain-containing protein 18 [OS=Homo sapiens]",1,1,1,1,510,54.8,4.82,2.35,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZSCAN18","ENSG00000121413","","","",157.4,138.9,177.6,135.2,141.5,126.2,1.176222387689253,0.23416085548400248,0.12042565502300102,0.9192809827789324,0.31563729923450556,0.5008116813353407,2979]
["Medium","Q8TBF5-1","Phosphatidylinositol-glycan biosynthesis class X protein [OS=Homo sapiens]",7,1,1,1,258,28.8,6.33,0,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","","PIGX","ENSG00000163964","3q29 copy number variation syndrome","Synthesis of glycosylphosphatidylinositol (GPI)","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways",54.1,72.7,46.3,64.6,39,60.4,1.055487804878049,0.07790990986119284,0.7989156993873792,0.09749904449377306,0.8984493419007139,0.04650640509169095,6943]
["High","Q8TC12","Retinol dehydrogenase 11 [OS=Homo sapiens]",17,5,11,5,318,35.4,8.82,21.05,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","RDH11","ENSG00000072042","","RA biosynthesis pathway; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision)","Retinol metabolism; Metabolic pathways; Biosynthesis of cofactors",561.5,557.4,639.5,470.2,571,534,1.116302691721686,0.15872827504767734,0.19927939626030516,0.7005376012142995,0.4192868569120083,0.3774887509044473,3711]
["High","Q8TCA0-1","Leucine-rich repeat-containing protein 20 [OS=Homo sapiens]",6,1,1,1,184,20.5,6.55,3.47,"","","","LRRC20","ENSG00000172731; ENSPTRG00000002588","","","",21,28.7,27.5,25.8,32.7,22.4,0.9542645241038319,-0.06753885516189716,0.765346361054029,0.11614197837300937,0.8807405139439732,0.05515202571012983,6785]
["High","Q8TCG2","Phosphatidylinositol 4-kinase type 2-beta [OS=Homo sapiens]",17,8,10,7,481,54.7,5.97,18.49,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","kinase activity;other molecular function","PI4K2B","ENSG00000038210","","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane; Synthesis of PIPs at the early endosome membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",257.6,248.9,242.5,268.1,268.1,290.2,0.9063407550822845,-0.14187453551894627,0.039507428881229836,1.4033212330122506,0.16701353801009342,0.7772483237938567,1847]
["High","Q8TCZ2","CD99 antigen-like protein 2 [OS=Homo sapiens]",8,2,3,2,262,28,5.14,6.32,"cell adhesion","plasma membrane;other membranes","","CD99L2","ENSG00000102181","","Cell surface interactions at the vascular wall","Cell adhesion molecules; Leukocyte transendothelial migration",154.5,176.6,160.9,185.2,174.1,209.7,0.8646748681898068,-0.2097703369673419,0.10719778515123522,0.9698141876519591,0.2938905570438359,0.5318143679581426,2848]
["Medium","Q8TD31-1","Coiled-coil alpha-helical rod protein 1 [OS=Homo sapiens]",1,1,1,1,782,88.6,5.95,1.83,"transport;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CCHCR1","ENSG00000204536; ENSG00000206355; ENSG00000206457; ENSG00000234114","","","",32.4,39.8,32.4,76.4,70.9,71.6,0.47784376427592506,-1.0653891029340048,2.2490393616256022E-4,3.648002943680772,0.014633749446310584,1.8346443850697616,120]
["High","Q8TD55","pleckstrin homology domain-containing family O member 2 [OS=Homo sapiens]",19,7,12,7,490,53.3,5.43,28.78,"","non-structural extracellular;other cell component","","PLEKHO2","ENSG00000241839","","Neutrophil degranulation","",514.5,455.2,433.9,524.8,384.4,415.1,1.0598806916861736,0.08390187309015773,0.6179527470891197,0.20904473278018643,0.789168310315971,0.10283036251162107,6114]
["High","Q8TDJ6-1","DmX-like protein 2 [OS=Homo sapiens]",2,4,5,3,3036,339.4,6.38,7.05,"other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","DMXL2","ENSG00000104093","","","Lysosome",36.7,24.3,26.1,43.9,33,36.9,0.7653778558875218,-0.3857559337077176,0.15050454862159324,0.8224503744129515,0.35827424257237805,0.44578441346599523,3280]
["High","Q8TDY2-1","RB1-inducible coiled-coil protein 1 [OS=Homo sapiens]",17,23,35,23,1594,183,5.41,54.38,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RB1CC1","ENSG00000023287","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Malignant pleural mesothelioma; Alzheimer's disease","Macroautophagy","Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",1304.6,1305.3,1288.1,1308.3,1293.6,1268.5,1.0071310458867302,0.010251416165327567,0.5153553871215899,0.28789317981987633,0.7180397684948918,0.14385150177497796,5604]
["High","Q8TE77","Protein phosphatase Slingshot homolog 3 [OS=Homo sapiens]",14,6,9,6,659,73,5.3,13.74,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SSH3","ENSG00000172830","Regulation of actin cytoskeleton","","Axon guidance; Regulation of actin cytoskeleton",274.5,274,267.1,322.9,317.1,280.7,0.8858477245574019,-0.17486937117104462,0.05939496910696558,1.2262503392210606,0.20675698563851416,0.6845398081453928,2243]
["High","Q8TEH3","DENN domain-containing protein 1A [OS=Homo sapiens]",16,11,18,11,1009,110.5,6.96,32.4,"transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DENND1A","ENSG00000119522","","RAB GEFs exchange GTP for GDP on RABs","",651.3,689.9,623.8,658.8,624.2,639,1.0223725286160248,0.03192097637221813,0.5438332551442031,0.2645342390360573,0.7397648181473759,0.13090632677539538,5740]
["High","Q8TEU7","Rap guanine nucleotide exchange factor 6 [OS=Homo sapiens]",6,6,7,5,1601,179.3,6.4,13.78,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","RAPGEF6","ENSG00000158987","","","Rap1 signaling pathway; Tight junction",119.4,103.3,119.7,125.3,116.8,117.8,0.9513753820505696,-0.0719134005235806,0.3891993828756614,0.4098278570314025,0.6189142121167341,0.20836954449573553,4910]
["High","Q8TF09","Dynein light chain roadblock-type 2 [OS=Homo sapiens]",13,1,2,1,96,10.8,7.5,4.85,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DYNLRB2","ENSG00000168589","Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome","Intraflagellar transport","Salmonella infection",84.2,93.3,81.9,112.1,92.8,84.3,0.8969571230982019,-0.15688907269941849,0.32836312973585685,0.48364561358431124,0.5601615287257091,0.25168672135297526,4577]
["High","Q8TF46","DIS3-like exonuclease 1 [OS=Homo sapiens]",4,3,3,3,1054,120.7,6.54,4.64,"RNA metabolism OR transcription;other metabolic processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","DIS3L","ENSG00000166938","","","RNA degradation",98.5,110.2,86.8,108.8,104.1,119.6,0.8887218045112782,-0.17019621021101944,0.20548005885753598,0.6872303185487348,0.4273810068086417,0.369184782175427,3754]
["Medium","Q8WTW4","GATOR complex protein NPRL2 [OS=Homo sapiens]",2,1,1,1,380,43.6,6.52,0,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;kinase activity","NPRL2","ENSG00000114388","22q11.2 copy number variation syndrome","Amino acids regulate mTORC1","mTOR signaling pathway",23.6,31.7,29.7,32.8,27.7,29.3,0.9465478841870824,-0.07925260371608292,0.6061834304988871,0.21739593887114997,0.7814231839747913,0.10711370787581627,6057]
["High","Q8WU90","Zinc finger CCCH domain-containing protein 15 [OS=Homo sapiens]",50,22,60,22,426,48.6,5.31,136.13,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","other molecular function","ZC3H15","ENSG00000065548","VEGFA-VEGFR2 signaling pathway","","",3125.6,3102.8,3108.3,3689.5,3288.6,3055.7,0.9305248260878233,-0.10388345347343814,0.27794863715602863,0.5560354510626132,0.5090834996280252,0.29321097905110993,4263]
["High","Q8WUD6-1","Cholinephosphotransferase 1 [OS=Homo sapiens]",4,1,1,1,406,45.1,6.92,2.1,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","CHPT1","ENSG00000111666","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids","Synthesis of PC","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways; Choline metabolism in cancer",9.8,12.4,11,13.7,11.3,17.3,0.7848699763593382,-0.34947442177302473,0.1853460592837499,0.7320166432438902,0.40010562092549606,0.39782534734687447,3617]
["High","Q8WUI4","histone deacetylase 7 [OS=Homo sapiens]",4,3,4,3,952,102.9,7.58,9.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","HDAC7","ENSG00000061273","MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling pathway; Ethanol effects on histone modifications; Gastrin signaling pathway","Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway","Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis",125.1,116.1,121.6,135.7,137.9,141.2,0.8746383799421407,-0.19324143828470347,0.004837498197451645,2.315379183799792,0.05506003779256916,1.259163494847908,686]
["High","Q8WUN7","Ubiquitin domain-containing protein 2 [OS=Homo sapiens]",12,2,2,2,234,26.2,5.67,5.68,"","other cell component","","UBTD2","ENSG00000168246","","","",54.1,43.9,45.6,48.2,46.4,44.3,1.033837293016559,0.04800914984165911,0.6643950240110336,0.17757362885857614,0.8193960428807693,0.08650613772141182,6331]
["High","Q8WUY8","N-acetyltransferase 14 [OS=Homo sapiens]",11,1,2,1,206,21.6,10.74,7.22,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus","nucleic acid binding activity;other molecular function","NAT14","ENSG00000090971","Metapathway biotransformation Phase I and II","","",13.1,11.2,11.7,14.7,17.3,16.1,0.7484407484407484,-0.4180399874403674,0.012840801241811153,1.8914078762640083,0.09266263964515849,1.0330953323759235,1082]
["High","Q8WV74","Nucleoside diphosphate-linked moiety X motif 8 [OS=Homo sapiens]",6,1,1,1,236,25.4,8.41,4.51,"other metabolic processes","mitochondrion","other molecular function","NUDT8","ENSG00000167799","","","",35.1,39.9,30.7,37,39.9,46.3,0.8579545454545454,-0.22102687931221843,0.2016226652419719,0.6954606486340992,0.4223959673220597,0.37428023672930344,3727]
["High","Q8WVD3-1","E3 ubiquitin-protein ligase RNF138 [OS=Homo sapiens]",8,2,2,2,245,28.2,6.93,2.4,"cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction","other cell component","nucleic acid binding activity;other molecular function","RNF138","ENSG00000134758; ENSGGOG00000027857; ENSPPYG00000009094; ENSPTRG00000009956","","Antigen processing: Ubiquitination & Proteasome degradation","",92.7,84.5,77.9,109.8,93.4,108.9,0.817366228772829,-0.29094545831673835,0.04973976576583083,1.3032962642379098,0.18798068301045842,0.725886776762876,2066]
["Medium","Q8WVL7","ankyrin repeat domain-containing protein 49 [OS=Homo sapiens]",5,1,1,1,239,27.3,5.15,2.54,"other biological processes","nucleus","","ANKRD49","ENSG00000168876","","","",25.9,19.7,23.2,22,20.6,28.8,0.9635854341736695,-0.053515509327001734,0.7939217963021452,0.10022227478592433,0.8945081364397042,0.048415704739095664,6930]
["High","Q8WVQ1","Soluble calcium-activated nucleotidase 1 [OS=Homo sapiens]",9,3,5,3,401,44.8,6.09,12.48,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","CANT1","ENSG00000171302","Proteoglycan biosynthesis","Neutrophil degranulation","Purine metabolism; Pyrimidine metabolism; Metabolic pathways",226.9,220.4,219.1,193.6,224.7,224.9,1.0360696517412935,0.05112099418661897,0.5089542356238931,0.2933212669943975,0.7126819712610039,0.14710422742571502,5576]
["Medium","Q8WW35","Tctex1 domain-containing protein 2 [OS=Homo sapiens]",13,1,1,1,142,16.1,4.93,0,"cell organization and biogenesis;transport;other biological processes","cytoskeleton;other cell component","other molecular function","DYNLT2B","ENSG00000213123","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 3q29 copy number variation syndrome","Intraflagellar transport","",23.9,31.5,22.3,31.5,36.2,29.7,0.797741273100616,-0.32600717367463206,0.1285975155671496,0.8907674216598537,0.32653313871489564,0.4860727371126538,3075]
["High","Q8WWM7-1","ataxin-2-like protein [OS=Homo sapiens]",30,26,79,25,1075,113.3,8.59,155.2,"cell organization and biogenesis;other biological processes","other membranes;cytosol;nucleus;other cell component","","ATXN2L","ENSG00000168488","16p11.2 distal deletion syndrome","","Amyotrophic lateral sclerosis; Spinocerebellar ataxia; Pathways of neurodegeneration",3487.6,3516.9,3499.7,4245.8,3577,3617.5,0.9181752226777271,-0.12315859400924285,0.22324557388447333,0.651217142771352,0.44983262990708844,0.34694904495504575,3875]
["High","Q8WX77","Insulin-like growth factor-binding protein-like 1 [OS=Homo sapiens]",3,1,4,1,278,29,7.93,5.24,"other biological processes","non-structural extracellular","other molecular function","IGFBPL1","ENSG00000137142","","","",233.6,223.3,213.2,246.3,226.6,220.3,0.96667628390075,-0.048895247377256104,0.47588463095265504,0.32249832083737395,0.6880939256441353,0.16235227600170704,5400]
["High","Q8WXE1","ATR-interacting protein [OS=Homo sapiens]",8,3,17,3,791,85.8,6.32,5.94,"DNA metabolism;other metabolic processes;stress response;signal transduction","nucleus","other molecular function","ATRIP","ENSG00000164053","miRNA regulation of DNA damage response; ATR signaling; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Fanconi Anemia Pathway; Activation of ATR in response to replication stress; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA)","Fanconi anemia pathway",503.8,463.8,489.1,509.2,423.9,495.2,1.0198837779178045,0.028404757515444655,0.7594996925969807,0.11947239757928836,0.8773744044677061,0.05681503936414621,6759]
["High","Q8WXF7","Atlastin-1 [OS=Homo sapiens]",9,4,5,3,558,63.5,6.18,6.09,"cell organization and biogenesis;developmental processes","other membranes;ER/Golgi;other cell component","other molecular function","ATL1","ENSG00000198513","","","",111.5,106.1,91.4,113.4,91.3,109.3,0.9840764331210191,-0.02315772098725244,0.8630396094235376,0.06396927177109504,0.932035030481187,0.030567764406990477,7230]
["High","Q8WXW3","Progesterone-induced-blocking factor 1 [OS=Homo sapiens]",11,8,9,8,757,89.8,6.02,21.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding","PIBF1","ENSG00000083535","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","","",316.3,327.6,299.3,416.7,382.2,409.1,0.780794701986755,-0.3569848312326785,0.00268318044020071,2.571350120638355,0.04258185544123403,1.37077541874708,492]
["High","Q8WY22","BRI3-binding protein [OS=Homo sapiens]",10,2,3,2,251,27.8,9.44,9.3,"","other membranes;mitochondrion","","BRI3BP","ENSG00000184992","","","",148.7,169.3,160.7,139.8,138.7,142.1,1.1381359961959105,0.18667295598798692,0.03298312476340846,1.481708202444671,0.15113394257787163,0.820637988216717,1704]
["High","Q8WYL5-1","Protein phosphatase Slingshot homolog 1 [OS=Homo sapiens]",3,2,2,2,1049,115.4,6.25,0,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SSH1","ENSG00000084112","Regulation of actin cytoskeleton","","Axon guidance; Regulation of actin cytoskeleton",36.8,38.2,38,40.7,37.2,36.7,0.9860383944153577,-0.020284271454354946,0.7093419435557087,0.14914435945750154,0.8490789353492217,0.07105193332135379,6523]
["High","Q8WZA9","Immunity-related GTPase family Q protein [OS=Homo sapiens]",29,10,21,10,623,62.7,4.88,52.89,"","","other molecular function","IRGQ","ENSG00000167378","","","",370.4,344.4,348.2,361.6,339.8,330.9,1.0297394168361906,0.04227929896032912,0.4488709526601074,0.347878497756277,0.6663088209829123,0.17632443725138064,5260]
["High","Q92503-1","SEC14-like protein 1 [OS=Homo sapiens]",12,6,8,6,715,81.2,6.43,13.9,"stress response;transport;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding","SEC14L1","ENSG00000129657","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","",357.3,314,356.6,389.2,420.5,402.8,0.8477525773195878,-0.23828482957881378,0.022131123155767502,1.654996545043619,0.12100827002817413,0.9171849478251392,1428]
["High","Q92530","proteasome inhibitor PI31 subunit [OS=Homo sapiens]",9,1,7,1,271,29.8,5.74,13.62,"protein metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMF1","ENSG00000125818","","Regulation of expression of SLITs and ROBOs; Neddylation; Ub-specific processing proteases; Separation of Sister Chromatids; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; ER-Phagosome pathway; Downstream TCR signaling; UCH proteinases; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome",29.2,28.4,16.9,24.4,24,19.5,1.09720176730486,0.13382885110479198,0.6337671745216777,0.19807025850842272,0.7994271564887334,0.0972211028699053,6190]
["High","Q92542-1","Nicastrin [OS=Homo sapiens]",19,10,31,10,709,78.4,5.99,46.36,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","NCSTN","ENSG00000162736; ENSGGOG00000003518","Alzheimer's disease and miRNA effects; Notch signaling; Inclusion body myositis; Alzheimer's disease; Notch signaling pathway","Neutrophil degranulation; Amyloid fiber formation; Degradation of the extracellular matrix; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; Nuclear signaling by ERBB4; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3","Notch signaling pathway; Alzheimer disease",1077,1095.8,1138.7,1053.5,1139.7,1078.8,1.0120721271393642,0.01731210995145728,0.6967825649678598,0.15690272486747525,0.8406177792442908,0.07540142881305568,6472]
["High","Q92574-1","Hamartin [OS=Homo sapiens]",21,18,32,18,1164,129.7,6.47,43.57,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TSC1","ENSG00000165699","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Glioblastoma signaling pathways; Nanoparticle triggered autophagic cell death; Wnt signaling pathway; BDNF-TrkB signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; CAMKK2 pathway; Malignant pleural mesothelioma","TP53 Regulates Metabolic Genes; Macroautophagy; TBC/RABGAPs; Energy dependent regulation of mTOR by LKB1-AMPK; Inhibition of TSC complex formation by PKB","Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Cellular senescence; Thermogenesis; Insulin signaling pathway; Human cytomegalovirus infection; Human papillomavirus infection; Herpes simplex virus 1 infection; Choline metabolism in cancer",1161.3,1167,1171.7,1176.2,1158.6,1158.5,1.0019179572324164,2.7643772557677903E-3,0.7523486483207595,0.12358085495049725,0.8746781188339027,0.05815173775787303,6716]
["High","Q92581-1","Sodium/hydrogen exchanger 6 [OS=Homo sapiens]",2,1,1,1,669,74.1,6.48,3.74,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","SLC9A6","ENSG00000198689","","Sodium/Proton exchangers; Defective SLC9A6 causes  X-linked, syndromic mental retardation,, Christianson type (MRXSCH)","Cardiac muscle contraction",62.2,37.3,61.3,52.6,55.2,47.4,1.036082474226804,0.05113884899180076,0.8363698962136699,0.07760160730292132,0.9200304521888326,0.036197797655859947,7098]
["High","Q92613","protein jade-3 [OS=Homo sapiens]",4,3,7,3,823,93.7,7.18,2.9,"protein metabolism;other metabolic processes","nucleus","other molecular function","JADE3","ENSG00000102221","","HATs acetylate histones","",106.1,82.3,113.5,104.6,113.3,110,0.9207075327843854,-0.11918514487943577,0.4241957573937138,0.3724336794067108,0.6477841724486832,0.18856966747461235,5113]
["High","Q92618","Zinc finger protein 516 [OS=Homo sapiens]",9,10,12,10,1163,124.2,8.72,24.97,"stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF516","ENSG00000101493","Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects","","Thermogenesis",597.3,614.3,587.4,642.1,618.4,656.4,0.9384944441546246,-0.09157989049641936,0.04441134737824848,1.3525060507384652,0.1783764404986441,0.7486625066700856,1944]
["High","Q92665","28S ribosomal protein S31, mitochondrial [OS=Homo sapiens]",26,8,14,8,395,45.3,9.29,34.3,"","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS31","ENSG00000102738","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",468.3,524.6,469.9,606.4,502.7,563.2,0.8747234347904086,-0.19310114917256782,0.11912498089239382,0.9239971560142979,0.31370247919319083,0.503482049055944,2965]
["High","Q92729-1","Receptor-type tyrosine-protein phosphatase U [OS=Homo sapiens]",1,1,1,1,1446,162.3,6.92,2.6,"cell adhesion;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PTPRU","ENSG00000060656","EPO receptor signaling","Signaling by SCF-KIT","",37.6,47.5,42.2,42.7,47.5,47.2,0.9264919941775835,-0.11014958491674244,0.3593446611251491,0.44448880318266554,0.5928086021688495,0.22708550299202415,4733]
["High","Q92738-1","USP6 N-terminal-like protein [OS=Homo sapiens]",4,2,2,2,828,94,9.07,7.22,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","USP6NL","ENSG00000148429","EGF/EGFR signaling pathway","Retrograde transport at the Trans-Golgi-Network","",111.2,117,120.8,101.5,120.4,117.2,{"$f":"AVERAGE(T5186:V5186)/AVERAGE(W5186:Y5186)","v":1.0291949277499262},{"$f":"LOG(Z5186,2)","v":0.04151625207158354},{"$f":"TTEST(T5186:V5186,W5186:Y5186,2,2)","v":0.6370222357781974},{"$f":"-LOG10(AB5186)","v":0.19584540799866929},{"$f":"AB5186*7808/AF5186","v":0.8013323049711882},{"$f":"-LOG10(AD5186)","v":0.09618734872543089},6207]
["High","Q92793-1","CREB-binding protein [OS=Homo sapiens]",10,18,33,12,2442,265.2,8.53,61.8,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CREBBP","ENSG00000005339","Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL-6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RORA activates gene expression; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; SUMOylation of transcription cofactors; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; Formation of the beta-catenin:TCF transactivating complex; Estrogen-dependent gene expression; HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production","cAMP signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Cell cycle; Wnt signaling pathway; Notch signaling pathway; TGF-beta signaling pathway; Adherens junction; JAK-STAT signaling pathway; Long-term potentiation; Melanogenesis; Thyroid hormone signaling pathway; Glucagon signaling pathway; Growth hormone synthesis, secretion and action; Huntington disease; Tuberculosis; Hepatitis B; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Renal cell carcinoma; Prostate cancer",1005.9,980.4,1018.6,1195.9,1197.2,1255.1,0.8236664656542951,-0.2798678421381338,6.7928653653307727E-4,3.1679469930455695,0.02346844812942596,1.6295156275343352,226]
["High","Q92802-1","NEDD4-binding protein 2-like 2 [OS=Homo sapiens]",4,3,3,3,583,67.4,6.39,2.14,"developmental processes;other biological processes","nucleus;other cell component","other molecular function","N4BP2L2","ENSG00000244754","","","",179.8,175.9,184.9,273.1,266,268.9,0.6690594059405942,-0.579793781104462,1.1474721080610995E-5,4.940257862184927,0.006891894015185435,2.161661409833128,13]
["High","Q92834","X-linked retinitis pigmentosa GTPase regulator [OS=Homo sapiens]",3,2,2,1,1020,113.3,4.86,2.16,"cell organization and biogenesis;transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity","RPGR","ENSG00000156313","Ciliary landscape","","",17.4,30.2,18.6,22.3,24,18.2,1.0263565891472866,0.03753205649660086,0.9043796717753522,0.043649208085867884,0.9519272684311068,0.021396232419823812,7418]
["High","Q92882","osteoclast-stimulating factor 1 [OS=Homo sapiens]",21,3,6,3,214,23.8,5.68,13.39,"signal transduction;other biological processes","other cell component","other molecular function","OSTF1","ENSG00000134996","","Neutrophil degranulation","",188.3,192.1,167,145.3,131.7,140.7,1.3105099353603067,0.39012829120216397,0.00788292261151597,2.1033127369860884,0.07042318049281086,1.1522843649618564,874]
["High","Q92888-1","Rho guanine nucleotide exchange factor 1 [OS=Homo sapiens]",18,13,24,13,912,102.4,5.66,48.85,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","ARHGEF1","ENSG00000076928","G protein signaling pathways; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway","G alpha (12/13) signalling events; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK","Vascular smooth muscle contraction; Platelet activation; Regulation of actin cytoskeleton; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis",759.9,743.6,718.7,884,874.6,878.6,0.842636129227969,-0.24701832004989116,3.5438278613661114E-4,3.4505273817834254,0.017293879963466624,1.762107559780715,160]
["High","Q92922","SWI/SNF complex subunit SMARCC1 [OS=Homo sapiens]",47,52,215,42,1105,122.8,5.76,457.93,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","SMARCC1","ENSG00000173473","Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",10068,10328.3,10072,10931.7,10419,10833.6,0.9466820779075512,-0.07904808485758262,0.03313758747788742,1.4796791127899358,0.1513089374428918,0.8201354185234542,1710]
["High","Q92993-1","Histone acetyltransferase KAT5 [OS=Homo sapiens]",7,4,4,4,513,58.5,8.48,8.03,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","HTATIP; KAT5","ENSANAG00000035412; ENSCANG00000040731; ENSCCAG00000033565; ENSG00000172977; ENSGGOG00000003283; ENSMLEG00000035009; ENSMNEG00000035393; ENSPANG00000021813; ENSPPAG00000042045; ENSPPYG00000003052; ENSPTRG00000003890; ENSRBIG00000038205; ENSRROG00000042827; ENSSBOG00000020725","Androgen receptor signaling pathway; ATM signaling in development and disease ; Joubert syndrome; Gastrin signaling pathway; Androgen receptor signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex; Estrogen-dependent gene expression; DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; HDR through Single Strand Annealing (SSA); Sensing of DNA Double Strand Breaks","Spinocerebellar ataxia; Human T-cell leukemia virus 1 infection",89.7,90,100,117.4,109.6,105.9,0.8401922499249025,-0.25120861666407124,0.020793381099591356,1.6820748866423119,0.11807615972771586,0.9278377801499578,1375]
["High","Q92995","Ubiquitin carboxyl-terminal hydrolase 13 [OS=Homo sapiens]",22,14,33,13,863,97.3,5.53,55.16,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","USP13","ENSG00000058056","","Ub-specific processing proteases; Regulation of PTEN stability and activity","",745.4,697.4,729.2,784.4,796.4,836.4,0.8985603177229854,-0.1543127440079473,0.017982093848394054,1.745159740085609,0.11081625001441262,0.9553965503104149,1267]
["High","Q93073-1","Selenocysteine insertion sequence-binding protein 2-like [OS=Homo sapiens]",2,2,2,2,1101,121.7,6.04,5.06,"protein metabolism;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","KIAA0256; SECISBP2L","ENSG00000138593; ENSGGOG00000007289","Thyroid hormones production and peripheral downstream signaling effects","","",93.4,76,64.1,81.9,77.4,68,1.027276726792785,0.03882486577917656,0.8374557812830246,0.07703811497979364,0.9207061025426437,0.0358789782867549,7102]
["High","Q969E2-1","Secretory carrier-associated membrane protein 4 [OS=Homo sapiens]",12,3,7,3,229,25.7,8.82,13.33,"transport","other membranes;ER/Golgi;other cytoplasmic organelle","","SCAMP4","ENSG00000227500; ENSPPAG00000030995; ENSPTRG00000042465","","","",296,322.2,315.9,298.2,269.2,299.2,1.0778906069697671,0.10821076919392804,0.14904043434165934,0.8266958924656044,0.35576512116773956,0.4488366319319506,3271]
["High","Q969E8","pre-rRNA-processing protein TSR2 homolog [OS=Homo sapiens]",11,2,3,2,191,20.9,4.39,4.37,"RNA metabolism OR transcription;other metabolic processes","","","TSR2","ENSG00000158526","","","",81.9,93.9,85.3,73.6,70.5,73.7,1.1988062442607899,0.2615985035959352,0.01787643500517551,1.7477190857610234,0.11051401783088707,0.9565826316577187,1263]
["High","Q969M3","Protein YIPF5 [OS=Homo sapiens]",5,1,2,1,257,28,4.36,5.15,"transport;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","","YIPF5","ENSG00000145817","","","",158.7,191.2,189.6,168.8,156.5,169.3,1.0907804286291953,0.12536071998544146,0.2585979304758212,0.5873749550415777,0.4875954216747674,0.3119403808853204,4141]
["High","Q969S9","Ribosome-releasing factor 2, mitochondrial [OS=Homo sapiens]",5,5,5,4,779,86.5,6.51,9.43,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","other molecular function","GFM2","ENSG00000164347","","Mitochondrial translation termination","",307.2,299.8,288.8,323.7,298.6,310.4,0.960437439691219,-0.05823645120652292,0.2438398166303297,0.6128953769336116,0.47419708300114927,0.32404112188967593,4015]
["High","Q969V3","Nicalin [OS=Homo sapiens]",19,9,35,9,563,62.9,6.89,107.04,"protein metabolism;other biological processes","other membranes;ER/Golgi;other cell component","translation activity;other molecular function","NCLN","ENSG00000125912","","","",829.3,932.9,882.6,860.9,869.7,899.1,1.0057420998592994,0.008260405586138338,0.8828646716693624,0.05410586137307462,0.9410795025794378,0.02637368574058627,7325]
["High","Q969Z3-1","Mitochondrial amidoxime reducing component 2 [OS=Homo sapiens]",7,2,7,1,335,38,9.16,17.82,"other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;other cytoplasmic organelle","other molecular function","MTARC2","ENSG00000117791","","Phase I - Functionalization of compounds","",97.6,111.1,108.1,88.5,94.3,98.1,1.1278034887860446,0.17351571095321097,0.07310975471640299,1.1360246731533534,0.23433537143911104,0.6301621524555557,2436]
["High","Q96A54","adiponectin receptor protein 1 [OS=Homo sapiens]",8,2,2,2,375,42.6,7.02,4.36,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","ADIPOR1","ENSG00000159346","AMP-activated protein kinase (AMPK) signaling; Leptin and adiponectin; Nonalcoholic fatty liver disease","AMPK inhibits chREBP transcriptional activation activity","AMPK signaling pathway; Longevity regulating pathway; Adipocytokine signaling pathway; Non-alcoholic fatty liver disease; Alcoholic liver disease",43,40.8,45.3,33,32.3,34.3,1.2961847389558234,0.37427135323910987,0.002313770915724438,2.6356796423427014,0.03970532595599211,1.4011512343411785,455]
["Medium","Q96A83","Collagen alpha-1(XXVI) chain [OS=Homo sapiens]",2,1,2,1,441,45.4,7.31,3.96,"other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","COL26A1","ENSG00000160963","","Collagen degradation; Collagen chain trimerization","Protein digestion and absorption",103.8,100.8,97.1,96.3,83.8,80.8,1.156381755461863,0.2096177523292504,0.05681425688103859,1.24554266943276,0.20265222372185898,0.6932486263420563,2189]
["Medium","Q96AG3","Solute carrier family 25 member 46 [OS=Homo sapiens]",3,1,1,1,418,46.1,7.43,2.43,"cell organization and biogenesis","other membranes;mitochondrion","","SLC25A46","ENSG00000164209","","","",109.4,123.6,102.4,97.6,111.2,97.9,1.0935767851320506,0.12905452229732636,0.2809358437536065,0.5513928469454391,0.5111971726935817,0.29141155681947567,4291]
["Medium","Q96AN5-1","Transmembrane protein 143 [OS=Homo sapiens]",3,1,1,1,459,51.7,9.67,0,"","other membranes;mitochondrion","","TMEM143","ENSG00000161558","","","",30.2,25,22.3,17.9,22.6,21.1,1.258116883116883,0.3312659594666984,0.12124628181820668,0.9163315707512253,0.3168309800657824,0.49917235923595105,2988]
["Medium","Q96AY2","crossover junction endonuclease EME1 [OS=Homo sapiens]",4,1,1,1,570,63.2,7.05,0,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EME1","ENSG00000154920","","Fanconi Anemia Pathway; Resolution of D-loop Structures through Holliday Junction Intermediates","Homologous recombination; Fanconi anemia pathway",15.9,14.2,15.7,17.3,22.3,18.2,0.7923875432525952,-0.3357218944037348,0.07009669924995776,1.1543024318376152,0.22785804652109498,0.642335630245867,2402]
["High","Q96B01","RAD51-associated protein 1 [OS=Homo sapiens]",13,4,8,4,352,38.4,9.11,14.53,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity","RAD51AP1","ENSG00000111247","","Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function","",411.6,376.2,421.1,793.7,739.3,709.5,0.5390858416945374,-0.8914130751074574,2.5704545041738185E-4,3.589990078535371,0.01543854520660706,1.8113936261835724,130]
["High","Q96BD8","Spindle and kinetochore-associated protein 1 [OS=Homo sapiens]",13,3,3,3,255,29.5,7.12,7.08,"cell cycle OR cell proliferation;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity","SKA1","ENSG00000154839; ENSG00000262634","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",165.5,159.9,169.6,201.7,169.8,174.6,0.9064273942501373,-0.14173663161992955,0.17420636213764212,0.7589359883018552,0.38664106753004823,0.4126920187646622,3518]
["High","Q96BN8","Ubiquitin thioesterase otulin [OS=Homo sapiens]",33,12,29,12,352,40.2,5.47,26.38,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","OTULIN","ENSG00000154124","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TNFR1 signaling","",1106.9,1068.2,1139.6,1230,1167.7,1127.1,0.9403937812074447,-0.08866309635883235,0.12629800514891532,0.8986035089827548,0.3232169204204296,0.4905059119665264,3051]
["High","Q96BR6-1","Zinc finger protein 669 [OS=Homo sapiens]",11,4,7,2,464,52.6,8.72,18.07,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF669","ENSG00000188295","","Generic Transcription Pathway","Herpes simplex virus 1 infection",175.9,197.8,195.2,141.4,125.3,170.4,1.3015328300160147,0.3802117029090924,0.04198229303384371,1.3769338443446524,0.1727979673211659,0.7624613705746796,1897]
["High","Q96BY7","autophagy-related protein 2 homolog B [OS=Homo sapiens]",2,4,6,4,2078,232.6,5.76,9.7,"cell organization and biogenesis;other metabolic processes;transport","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","ATG2B","ENSG00000066739","Alzheimer's disease and miRNA effects; Alzheimer's disease","","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",277.1,286.8,283.2,337.8,309,310.5,0.8848845711898049,-0.1764388198419936,0.019836068371895596,1.7025444034316537,0.11627629267849911,0.9345088236073005,1332]
["High","Q96C36","Pyrroline-5-carboxylate reductase 2 [OS=Homo sapiens]",25,7,29,6,320,33.6,7.77,64.53,"other metabolic processes;stress response","mitochondrion","other molecular function","PYCR2","ENSG00000143811","Metabolic reprogramming in colon cancer","Glutamate and glutamine metabolism","Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids",1384.4,1254.8,1339.9,1252.2,1351.1,1367.5,1.0020902588898961,0.003012458820898756,0.9603993276316569,0.017548152661202937,0.9786998107736854,0.00935049564962644,7662]
["High","Q96C92-4","Isoform 4 of Serologically defined colon cancer antigen 3 [OS=Homo sapiens]",15,4,5,4,362,40,4.88,9.17,"","","","ENTR1","","","","",105.6,109.9,107.2,101.7,104.3,105.1,1.0372870459659274,0.05281518295256023,0.07555288266750572,1.1217489608059963,0.23931720400319864,0.6210260797606096,2465]
["Medium","Q96CN4","EVI5-like protein [OS=Homo sapiens]",1,1,1,1,794,91.3,5.34,1.95,"transport;other biological processes","","enzyme regulator activity;other molecular function","EVI5L","ENSG00000142459","","","",39.3,27.5,39.4,30.2,27.2,29.6,1.2206896551724138,0.287696460068063,0.18964092812624236,0.7220679278567763,0.4053425586667671,0.39217779541005765,3653]
["High","Q96CS7-1","Pleckstrin homology domain-containing family B member 2 [OS=Homo sapiens]",14,3,5,3,222,24.7,5.39,7.1,"other biological processes","other membranes;other cytoplasmic organelle","other molecular function","PLEKHB2","ENSG00000115762","","","",359.6,366.5,384.5,413.4,427.2,403.3,0.8928370447785193,-0.16353120749455177,0.011906153808830125,1.9242285113445943,0.08870539020929925,1.0520499893336668,1048]
["High","Q96CW6","Probable RNA polymerase II nuclear localization protein SLC7A6OS [OS=Homo sapiens]",42,7,10,7,309,35,4.6,22.52,"transport;developmental processes;other biological processes","nucleus;other cell component","","SLC7A6OS","ENSG00000103061","","","",346.6,309.8,319.8,312.9,349.2,337.2,0.9768838186730714,-0.03374110300182297,0.6416490703161971,0.19270243064557718,0.8040436432400686,0.09472037724170329,6231]
["High","Q96D71","RalBP1-associated Eps domain-containing protein 1 [OS=Homo sapiens]",12,8,9,8,796,86.6,5.69,18.76,"transport","plasma membrane;other membranes;cytosol","other molecular function","REPS1","ENSG00000135597","","Cargo recognition for clathrin-mediated endocytosis","",421.6,416.7,431.8,461.1,468.4,414.2,0.9452258688695392,-0.08126898146737647,0.2347689054207148,0.6293594248795379,0.4640697755759345,0.33341671584736265,3950]
["High","Q96DE0","U8 snoRNA-decapping enzyme [OS=Homo sapiens]",25,5,13,4,195,21.3,6.89,32.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT16","ENSG00000198585","","Phosphate bond hydrolysis by NUDT proteins","Purine metabolism; Metabolic pathways; RNA degradation",493,514,477.4,520.1,482,515.3,0.9782522736259391,-0.031721536686868695,0.5295341976505958,0.2761059876407897,0.7289497558631616,0.13730240515716444,5672]
["High","Q96DM3","Uncharacterized protein C18orf8 [OS=Homo sapiens]",6,3,4,3,657,74.9,7.83,7.57,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle","","RMC1","ENSG00000141452","","","",68.5,86,84.8,81.5,78.9,68,1.0477232924693518,0.06725774617565584,0.630972511587784,0.1999895604480681,0.7980938555770967,0.09794603275654223,6173]
["High","Q96DU9-1","Polyadenylate-binding protein 5 [OS=Homo sapiens]",5,2,14,1,382,43.3,9.51,32.73,"","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity","PABPC5","ENSANAG00000005063; ENSCCAG00000032154; ENSG00000174740; ENSGGOG00000007622; ENSNLEG00000035086; ENSPPYG00000020526; ENSPTRG00000022078","","","mRNA surveillance pathway; RNA degradation",110.2,96.6,104.8,78.3,70,79.9,1.3654688869412794,0.4493964417729874,0.005140223717453155,2.289017978837204,0.056448476492087535,1.248347774908335,711]
["High","Q96DZ1","Endoplasmic reticulum lectin 1 [OS=Homo sapiens]",10,4,8,4,483,54.8,6.28,15.24,"protein metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi","other molecular function","ERLEC1","ENSG00000068912","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis","Protein processing in endoplasmic reticulum",163.7,169.3,169.2,147.6,168.4,161.7,1.0512874188821437,0.07215715180023459,0.27118739820426163,0.5667304955480017,0.5017609490945201,0.29950314185104016,4220]
["High","Q96E52-1","Metalloendopeptidase OMA1, mitochondrial [OS=Homo sapiens]",6,3,4,3,524,60.1,9.25,7.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion","other molecular function","OMA1","ENSG00000162600","","Regulation of Apoptosis","Spinocerebellar ataxia",155.2,156.7,163.2,181.1,184.7,213.5,0.8201277403763162,-0.2860794582609627,0.0300867765564148,1.5216243393038467,0.1429808590094259,0.844722098080273,1643]
["High","Q96ED9-1","Protein Hook homolog 2 [OS=Homo sapiens]",13,8,8,8,719,83.2,5.47,19.23,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","HOOK2","ENSG00000095066","","","",285.1,269.7,271.6,311.8,295.8,306.8,0.9037620297462816,-0.14598514934941886,0.012322833745323893,1.9092894108044236,0.09077045838064995,1.0420554714105583,1060]
["High","Q96EK5","KIF1-binding protein [OS=Homo sapiens]",16,8,19,8,621,71.8,5.49,37.08,"transport;developmental processes;other biological processes","cytoskeleton;mitochondrion","cytoskeletal activity","KIFBP","ENSG00000198954","","","",779.3,777.7,782.1,766.6,773.7,827.3,0.9879624936644701,-0.01747182153020231,0.6467425959673323,0.18926853446907238,0.8080918849916676,0.09253925447784526,6249]
["High","Q96EP0-1","E3 ubiquitin-protein ligase RNF31 [OS=Homo sapiens]",18,12,18,12,1072,119.6,6.57,29.82,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RNF31","ENSG00000092098; ENSG00000285152","","Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway","Necroptosis; NOD-like receptor signaling pathway; Shigellosis",556.2,515.1,520.8,507.3,481,486.9,1.0792434924078094,0.11002039370343313,0.061561641548365395,1.2106898081730508,0.21109938393045102,0.6755130341295582,2277]
["High","Q96ES7","SAGA-associated factor 29 [OS=Homo sapiens]",29,5,6,5,293,33.2,8.1,10.71,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SGF29","ENSG00000176476","","HATs acetylate histones","",121.2,134.1,127.1,107.8,98.7,110.1,1.2078332280480097,0.27242126784356696,0.012643674317579614,1.898126699474318,0.09217722602396043,1.0353763656475383,1071]
["High","Q96EX3","Wd repeat-containing protein 34 [OS=Homo sapiens]",8,3,3,3,536,57.8,6.64,3.04,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","DYNC2I2","ENSG00000119333","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 3q29 copy number variation syndrome","Intraflagellar transport","",75.3,73.7,80.2,73.5,76,73.3,1.0287253141831239,0.04085781141687307,0.3751550810909989,0.4257891671004239,0.6054590477797683,0.21791522646764944,4838]
["High","Q96F44-1","E3 ubiquitin-protein ligase TRIM11 [OS=Homo sapiens]",17,6,10,6,468,52.7,5.69,23.99,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM11","ENSG00000154370; ENSPPAG00000018913; ENSPTRG00000002071","","Antigen processing: Ubiquitination & Proteasome degradation","",426,457,447.9,412.1,380.6,375,1.1397619251520084,0.18873250397579555,0.021116738560061996,1.6753731569121173,0.11904656655376468,0.9242831256539493,1385]
["High","Q96F46","Interleukin-17 receptor A [OS=Homo sapiens]",4,2,2,2,866,96.1,5.21,2.5,"stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","IL17RA","ENSG00000177663","IL-17 signaling pathway","Interleukin-17 signaling","Cytokine-cytokine receptor interaction; IL-17 signaling pathway; Alcoholic liver disease",13.9,11.5,16.6,14.6,8.2,13.1,1.16991643454039,0.22640548384307144,0.4497875485605927,0.34699257127983224,0.6671620781081132,0.17576864722709593,5264]
["High","Q96FL9","Polypeptide N-acetylgalactosaminyltransferase 14 [OS=Homo sapiens]",8,3,5,3,552,64.3,7.72,6.62,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT14","ENSG00000158089","","O-linked glycosylation of mucins","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways",95.8,92.5,92.3,127.1,128,119.5,0.7490656700480514,-0.416835890623146,4.3033107244780269E-4,3.3661972941558513,0.01836079242443958,1.7361085792276454,183]
["High","Q96FW1","Ubiquitin thioesterase otub1 [OS=Homo sapiens]",50,10,66,10,271,31.3,4.94,168.33,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","OTUB1","ENSG00000167770","","Ub-specific processing proteases; Ovarian tumor domain proteases","",2359.4,2384.5,2514.2,2256.9,2628.6,2393,0.997197224702892,-0.004049227213330156,0.9570632306448026,0.019059368583682793,0.9775967693451882,0.009840242308022632,7644]
["High","Q96G21","U3 small nucleolar ribonucleoprotein protein IMP4 [OS=Homo sapiens]",34,8,17,8,291,33.7,9.47,36.47,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","IMP4","ENSG00000136718","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",442.6,428.4,469.5,414.3,441.9,444.2,1.030836665641341,0.04381575817956755,0.4347135482000386,0.36179682445874395,0.6552593406073168,0.1835867795453416,5180]
["High","Q96G97-4","Isoform 3 of Seipin [OS=Homo sapiens]",15,6,13,6,462,51.1,5.27,25.3,"","","","BSCL2","","","","",1005,1113.1,1120.5,1091.8,1123.7,1127.9,0.9686546629179876,-0.045945675784806586,0.4213497327124616,0.3753572772418265,0.6449517179021564,0.19047279611437806,5101]
["High","Q96GM5","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [OS=Homo sapiens]",57,22,71,21,515,58.2,9.25,144.54,"cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SMARCD1","ENSG00000066117","Tumor suppressor activity of SMARCB1; Thermogenesis","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Thermogenesis; Hepatocellular carcinoma",2075.1,2136.7,2084.6,2191.5,2277.6,2230.2,{"$f":"AVERAGE(T5506:V5506)/AVERAGE(W5506:Y5506)","v":0.9398593882942993},{"$f":"LOG(Z5506,2)","v":-0.08948316254879568},{"$f":"TTEST(T5506:V5506,W5506:Y5506,2,2)","v":0.012889412739855981},{"$f":"-LOG10(AB5506)","v":1.8897668692757654},{"$f":"AB5506*7808/AF5506","v":0.09267084224014319},{"$f":"-LOG10(AD5506)","v":1.0330568898699584},1086]
["High","Q96GQ5-1","RUS1 family protein C16orf58 [OS=Homo sapiens]",5,2,5,2,468,51,6.93,16.07,"","other membranes","","C16orf58; RUSF1","ENSG00000140688","","","",181.3,175.6,153.6,164.1,151.3,149,1.0992678725236866,0.13654298889959757,0.1870034027088603,0.7281504909809521,0.4019054688551558,0.39587608418503134,3633]
["Medium","Q96GX2","Ataxin-7-like protein 3B [OS=Homo sapiens]",10,1,1,1,97,10.8,4.36,2.57,"other biological processes","other cell component","","ATXN7L3B","ENSG00000253719","","","",106.6,112.8,98.7,126.8,125.6,107.1,0.8848400556328233,-0.1765113987871469,0.14237543793247043,0.8465649270648162,0.3467459199553117,0.45998864042430676,3206]
["High","Q96H22","Centromere protein N [OS=Homo sapiens]",9,2,3,2,339,39.5,9.13,6.1,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","","CENPN","ENSG00000166451","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere","",85.2,78.9,93.4,97.5,97.4,87.5,0.9118271954674221,-0.13316765631323724,0.19574859982589418,0.7083013357326635,0.41408969586577665,0.3829055762696853,3691]
["High","Q96HB5-1","Coiled-coil domain-containing protein 120 [OS=Homo sapiens]",1,1,1,1,630,67.5,9.38,2.12,"cell organization and biogenesis;other biological processes","cytoskeleton;other cytoplasmic organelle;other cell component","","CCDC120","ENSG00000147144","","","",24,25.1,28.8,26.2,23.8,29,0.9860759493670888,-0.02022932500279587,0.8692203944565402,0.060870092411305886,0.9341875898027069,0.02956590638671084,7265]
["High","Q96HP0","Dedicator of cytokinesis protein 6 [OS=Homo sapiens]",14,23,38,20,2047,229.4,6.74,59.64,"signal transduction","cytosol;other cell component","enzyme regulator activity","DOCK6","ENSG00000130158","","CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production","",875.7,785.1,864.5,783.6,768.7,798.6,1.0741843549279,0.10324161447398479,0.12279906427963679,0.9108049424761103,0.31875501791735505,0.49654296973707956,3008]
["High","Q96I27","Zinc finger protein 625 [OS=Homo sapiens]",21,2,3,1,306,34.7,8.98,9.54,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF625","ENSG00000257591","","Generic Transcription Pathway","",31.1,34.2,34.4,28.9,25.3,26.8,1.2308641975308645,0.29967159662620924,0.013995973831715572,1.853996878189142,0.09670846343188953,1.0145355170139265,1130]
["High","Q96II8-1","Leucine-rich repeat and calponin homology domain-containing protein 3 [OS=Homo sapiens]",19,11,15,11,777,86,6.71,30.21,"cell organization and biogenesis","cytosol;other cell component","","LRCH3","ENSG00000186001","","","",481.6,505.3,451.1,566.5,479.8,549.4,0.9011718994798521,-0.15012576701434086,0.16313969753739657,0.7874403472143499,0.3726725448718527,0.4286726009404324,3418]
["High","Q96IY1","Kinetochore-associated protein NSL1 homolog [OS=Homo sapiens]",22,5,8,5,281,32.1,6.79,9.22,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","","NSL1","ENSG00000117697","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",287.8,297.5,262.8,263.6,235.8,254.9,1.1243537054222457,0.1690959579657881,0.07693723877812401,1.1138634042644868,0.24213057653349143,0.6159503638780605,2481]
["High","Q96JA1","Leucine-rich repeats and immunoglobulin-like domains protein 1 [OS=Homo sapiens]",2,2,2,2,1093,119,7.09,2.24,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","","LRIG1","ENSG00000144749","","Signaling by EGFR; Negative regulation of MET activity","",83.9,91.4,85.7,90.1,77.5,87.6,1.0227272727272727,0.03242147769237743,0.6874017960718206,0.16278933745474092,0.8336802149314656,0.0790005051457002,6438]
["High","Q96JC9","ELL-associated factor 1 [OS=Homo sapiens]",18,3,4,3,268,29,5.4,9.02,"other biological processes","non-structural extracellular;nucleus;other cell component","other molecular function","EAF1","ENSG00000144597","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",86.4,112.6,81.9,87,66.3,84.5,1.1812447434819175,0.2403079093807425,0.28265425204332295,0.5487444769469647,0.5131282027329146,0.28977411484242116,4301]
["High","Q96JJ7-1","Protein disulfide-isomerase TMX3 [OS=Homo sapiens]",24,9,19,9,454,51.8,4.91,47.36,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TMX3","ENSG00000166479; ENSGGOG00000005485","","Platelet degranulation","",644.9,576,641.3,617.6,656.6,617.3,0.9845096484271743,-0.022522749938971055,0.7254222025124474,0.13940915639126258,0.858586714751734,0.06621583581308002,6597]
["High","Q96JM7","Lethal(3)malignant brain tumor-like protein 3 [OS=Homo sapiens]",11,7,9,6,780,88.3,6.46,13.67,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","other molecular function","L3MBTL3","ENSG00000198945","","","",295.1,338.1,290.7,390.7,390.6,411,0.7748888702507759,-0.36793867202830016,0.00569731042571311,2.2443301167726766,0.06003319811601615,1.221608520093369,741]
["High","Q96JP5-1","E3 ubiquitin-protein ligase ZFP91 [OS=Homo sapiens]",13,5,6,5,570,63.4,7.36,12.7,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","other molecular function","ZFP91","ENSG00000186660","","","",265.1,227.9,201.6,217.4,242.3,225.8,1.013274981765135,0.0190257447155036,0.8857705700514444,0.05267875335424988,0.9425043078443279,0.025716656115543572,7338]
["High","Q96K31-1","Uncharacterized protein C8orf76 [OS=Homo sapiens]",4,2,2,2,380,43.2,5.43,4.94,"","","","C8orf76","ENSG00000189376","","","",141.2,132,155.4,137.8,158.5,147.4,0.9659679963939599,-0.04995270314367627,0.6081431570422321,0.21599417566933066,0.782657288641132,0.10642836595474352,6067]
["High","Q96KM6","zinc finger protein 512B [OS=Homo sapiens]",7,5,7,5,892,97.2,9.83,9.47,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512B","ENSG00000196700","","RHOV GTPase cycle","",171.2,170.9,180.5,183.5,179.3,185.1,0.9538236904544626,-0.06820547898595866,0.07884934273888185,1.103201922450062,0.24596710671401895,0.6091229673996499,2503]
["High","Q96KR1","Zinc finger RNA-binding protein [OS=Homo sapiens]",34,26,83,26,1074,116.9,9.04,188.67,"","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZFR","ENSG00000056097","Exercise-induced circadian regulation","","",3076.3,3200.9,3044,3220.7,3190.7,3241.6,0.9656272661348805,-0.05046168126107938,0.09170661957222412,1.037599314930514,0.26918995699997217,0.5699411469029455,2660]
["High","Q96L73-1","Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [OS=Homo sapiens]",4,8,9,8,2696,296.5,8.03,12.95,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD1","ENSG00000165671","Histone modifications; Pathways affected in adenoid cystic carcinoma","PKMTs methylate histone lysines","Lysine degradation; Metabolic pathways",334.3,300.5,302.1,401.4,397.5,405.9,0.7776394422310758,-0.3628266999301985,0.001374882351507826,2.8617344627624095,0.031573768825215016,1.5006735751460294,340]
["High","Q96LR4","Protein FAM19A4 [OS=Homo sapiens]",8,1,1,1,140,15.7,8.9,4.32,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","TAFA4","ENSG00000163377","","","",81.1,89.5,69,70.6,71.9,70.8,1.1233005157055789,0.16774394244821403,0.21549897286729092,0.6665547954760144,0.4402448927649941,0.356305673536373,3822]
["High","Q96LR5","Ubiquitin-conjugating enzyme E2 E2 [OS=Homo sapiens]",34,6,26,3,201,22.2,7.71,57.57,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","UBE2E2","ENSG00000182247","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",892.5,874.9,832.7,968.6,1052.3,1051.1,0.8463867187500002,-0.24061110560159044,0.008765468816720808,2.057224850925585,0.07488050385224952,1.125631242000781,914]
["High","Q96ME7","Zinc finger protein 512 [OS=Homo sapiens]",20,13,35,13,567,64.6,9.76,77.31,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512","ENSG00000243943","","","",849.7,888.8,812.4,1019.9,1016.9,1040.7,0.8288870836718116,-0.27075251297588104,1.6603213153101382E-3,2.779807856560887,0.033325935295479586,1.4772176532279593,389]
["High","Q96MR9","Zinc finger protein 560 [OS=Homo sapiens]",2,2,4,1,790,91.1,8.69,5.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF560","ENSG00000198028","","Generic Transcription Pathway","Herpes simplex virus 1 infection",73,96.4,62.9,68.8,67.4,59.9,1.1845996940336565,0.2443996186166589,0.3063684826728917,0.5137559143177699,0.5397394207378019,0.2678158613795079,4432]
["High","Q96MW5","Conserved oligomeric Golgi complex subunit 8 [OS=Homo sapiens]",11,6,10,6,612,68.4,5.2,24.18,"transport","other membranes;ER/Golgi","","COG8","ENSG00000213380","","COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",776.4,749.9,752,832,825.4,839.6,0.912414897877453,-0.1322380917725476,1.5154956763862445E-3,2.819445298309407,0.03215486478593423,1.4927533123242893,368]
["High","Q96N21-1","AP-4 complex accessory subunit tepsin [OS=Homo sapiens]",4,1,3,1,525,55.1,7.03,2.75,"","other membranes;cytosol;ER/Golgi;nucleus;other cell component","","TEPSIN","ENSG00000167302","","","",27.8,26.1,33.7,35.5,37.2,30.9,0.8455598455598456,-0.24202122808538032,0.14737579329193395,0.831573844177552,0.3535207969349986,0.45158503242312725,3255]
["High","Q96N67","Dedicator of cytokinesis protein 7 [OS=Homo sapiens]",22,37,86,34,2140,242.4,6.8,150.9,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other cell component","enzyme regulator activity;other molecular function","DOCK7","ENSG00000116641","","CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production; MET activates RAP1 and RAC1","",2761.5,2609.3,2659.4,2905.6,2914.1,2922.7,0.9185349560761348,-0.1225934688168588,6.2154877651510055E-3,2.2065247840937086,0.06286337884753763,1.2016022797708092,772]
["High","Q96NT0","Coiled-coil domain-containing protein 115 [OS=Homo sapiens]",7,1,1,1,180,19.7,6.95,3.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","CCDC115","ENSG00000136710","","RHOA GTPase cycle","",33.6,31.6,35.2,41.2,36,40.1,0.855924978687127,-0.22444374407773648,0.040978306255631584,1.387445996130885,0.1702813279637953,0.7688329715727752,1879]
["High","Q96P70","Importin-9 [OS=Homo sapiens]",29,23,79,23,1041,115.9,4.81,153.34,"transport","cytosol;nucleus;other cell component","other molecular function","IPO9","ENSG00000198700","","","Nucleocytoplasmic transport",3069.2,2787.5,3055.5,2852.7,3128.2,3065.9,0.9851218110271036,-0.02162596899923376,0.7357099422904789,0.13329337491751633,0.8647332875815233,0.06311782270043041,6643]
["High","Q96PK6-1","RNA-binding protein 14 [OS=Homo sapiens]",46,28,138,28,669,69.4,9.67,261.35,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RBM14","ENSCATG00000036313; ENSG00000239306; ENSGGOG00000014455; ENSMFAG00000003827; ENSMLEG00000024601; ENSMMUG00000020363; ENSPANG00000004924; ENSPPYG00000003015; ENSRBIG00000043267; ENSRROG00000044302","Ciliary landscape","RUNX2 regulates bone development","",5329.4,5248.3,5211.8,4797.6,4783.3,4859.1,1.09345567867036,0.12889474442958,4.2327778548297934E-4,3.373374523624549,0.01815908213764342,1.7409061069509884,182]
["High","Q96PV7-1","Protein FAM193B [OS=Homo sapiens]",8,6,7,6,902,96.5,7.9,7.56,"","nucleus;other cell component","","FAM193B","ENSG00000146067","","","",315.4,261.7,270.6,291.9,254.3,242.4,1.074942936850114,0.1042600766441162,0.4274903146985995,0.36907372028224716,0.6507787828361601,0.18656661468936528,5129]
["High","Q96Q05","Trafficking protein particle complex subunit 9 [OS=Homo sapiens]",5,5,5,5,1148,128.4,6.62,2.54,"developmental processes;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC9","ENSG00000167632","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",119.1,118.4,148.2,128.1,128.5,113.9,1.041025641025641,0.05800560343556565,0.6670622370162724,0.17583364444659352,0.8207409307631666,0.08579390755235157,6346]
["High","Q96QC0","Serine/threonine-protein phosphatase 1 regulatory subunit 10 [OS=Homo sapiens]",27,22,38,22,940,99,9.17,64.22,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","PPP1R10","ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104","","","",2405.6,2557.6,2162.3,2230.5,1991,2143.6,{"$f":"AVERAGE(T5698:V5698)/AVERAGE(W5698:Y5698)","v":1.1194639518625},{"$f":"LOG(Z5698,2)","v":0.16280807235618075},{"$f":"TTEST(T5698:V5698,W5698:Y5698,2,2)","v":0.13309122603419637},{"$f":"-LOG10(AB5698)","v":0.8758505742062582},{"$f":"AB5698*7808/AF5698","v":0.3340328810270027},{"$f":"-LOG10(AD5698)","v":0.47621078065632616},3111]
["High","Q96QU8","Exportin-6 [OS=Homo sapiens]",6,6,11,6,1125,128.8,6.35,18.38,"transport","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","XPO6","ENSG00000169180","","","Nucleocytoplasmic transport",431.2,424.6,493.5,416.2,380.9,703.9,0.8989340439706862,-0.1537128277873821,0.6541240487980367,0.18433988378610477,0.8131508633999475,0.08982887253154248,6281]
["High","Q96RL1","BRCA1-A complex subunit RAP80 [OS=Homo sapiens]",13,8,8,8,719,79.7,5.45,16.69,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","UIMC1","ENSG00000087206","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","Homologous recombination",431.5,446.5,464.6,590,531.6,583.3,0.787494867734178,-0.3446575736967507,0.004366662412673866,2.3598503821524095,0.05197393310694748,1.2842144168694343,656]
["High","Q96RQ1","Endoplasmic reticulum-Golgi intermediate compartment protein 2 [OS=Homo sapiens]",13,4,9,4,377,42.5,6.77,16.2,"transport","other membranes;ER/Golgi;nucleus;other cell component","","ERGIC2","ENSG00000087502","","","",376,430.9,443.2,408.2,435.1,410.7,0.99688995215311,-0.004493842265696348,0.9564427171078824,0.01934103545259783,0.977858417595698,0.009724021396561146,7637]
["High","Q96RS6","NudC domain-containing protein 1 [OS=Homo sapiens]",29,12,33,12,583,66.7,5.11,51.84,"other biological processes","cytosol;nucleus","","NUDCD1","ENSG00000120526","","","",853.3,900.8,984.6,813.7,963.3,862.5,1.0375828755446106,0.053226574398917356,0.601651450446615,0.22065503197488517,0.7795709467452988,0.10814435465358808,6026]
["High","Q96RW7-1","Hemicentin-1 [OS=Homo sapiens]",1,3,3,3,5635,613,6.49,4.34,"cell adhesion;cell cycle OR cell proliferation;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","HMCN1","ENSG00000143341","","","",82.7,74.4,75,86,75.9,89.4,0.9235972940708318,-0.11466414853617289,0.2578840321797497,0.5885755479392742,0.4869549028438901,0.3125112571692043,4135]
["High","Q96S55-1","ATPase WRNIP1 [OS=Homo sapiens]",12,7,15,7,665,72.1,6.1,31.84,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","WRNIP1","ENSG00000124535; ENSPTRG00000017666","","","",490.8,512.3,473.4,514.3,494.3,502.7,0.9769734665519751,-0.03360871405879275,0.41124780685810464,0.38589640508321643,0.6371077134817621,0.19578713687010635,5040]
["High","Q96S99","Pleckstrin homology domain-containing family F member 1 [OS=Homo sapiens]",7,2,2,2,279,31.2,8.24,1.73,"cell organization and biogenesis;other biological processes","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PLEKHF1","ENSG00000166289","","","",65.6,73.4,68.7,84.5,80.6,83.3,0.8361513687600645,-0.2581639573758337,0.005952637997773261,2.2252905277203525,0.06188841209935236,1.2083906600658856,751]
["High","Q96SB8","structural maintenance of chromosomes protein 6 [OS=Homo sapiens]",26,27,50,27,1091,126.2,6.99,113.81,"cell organization and biogenesis;DNA metabolism;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC6","ENSG00000163029","","SUMOylation of DNA damage response and repair proteins","",2580.8,2451.9,2616.7,2683.5,2764.6,2607.1,0.9496226040321779,-0.0745738187775883,0.11603062605058276,0.9354273644863028,0.3086770453843101,0.5104956654113006,2935]
["High","Q96SQ9","Cytochrome P450 2S1 [OS=Homo sapiens]",24,13,55,13,504,55.8,8.62,158.41,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","CYP2S1","ENSG00000167600","Vitamin D receptor pathway; Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II","CYP2E1 reactions; Miscellaneous substrates","Retinol metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways",2260.7,2305,2265.3,2306.2,2330.7,2372.7,0.9745206573841588,-0.03723532757780967,0.06798033125631178,1.1676167235064485,0.22367906719312367,0.6503746570651521,2373]
["High","Q96ST8","Centrosomal protein of 89 kDa [OS=Homo sapiens]",3,3,3,3,783,89.5,6.8,5.59,"cell-cell signaling;cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","","CEP89","ENSG00000121289","","Anchoring of the basal body to the plasma membrane","",192.9,187.2,190.6,197.5,157.1,173.5,1.0806665404279494,0.11192142160501208,0.29684422044128944,0.5274714023717134,0.5291688751610931,0.2764057082171775,4380]
["High","Q96T21","selenocysteine insertion sequence-binding protein 2 [OS=Homo sapiens]",13,7,9,7,854,95.4,8.12,24.57,"protein metabolism;other metabolic processes;developmental processes;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","SECISBP2","ENSG00000187742","","Selenocysteine synthesis","",390.6,344.9,375.8,487.6,408.9,432,0.836507339104253,-0.2575498970709993,0.05490365976737502,1.260398705389595,0.19855848794055772,0.7021115430651905,2159]
["High","Q96T51","RUN and FYVE domain-containing protein 1 [OS=Homo sapiens]",25,16,34,14,708,79.8,5.74,68.63,"transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RUFY1","ENSG00000176783; ENSG00000284260","","Synthesis of PIPs at the plasma membrane","Endocytosis",1689.5,1661,1717,1614.5,1533.5,1519.5,1.085698982324585,0.11862416124069716,0.016786725871164546,1.7750340015835957,0.1065615899203681,0.9723993083643583,1230]
["High","Q96TC7","Regulator of microtubule dynamics protein 3 [OS=Homo sapiens]",20,10,27,10,470,52.1,5.1,37.86,"other biological processes","non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component","cytoskeletal activity","RMDN3","ENSG00000137824","","","",1150.4,1144,1162.8,1138.7,1091.4,1129.3,1.0291123414895513,0.041400480446877296,0.10287178241013097,0.9877037352876041,0.2877903536575789,0.5409237671175998,2791]
["High","Q99460","26S proteasome non-ATPase regulatory subunit 1 [OS=Homo sapiens]",51,38,225,38,953,105.8,5.39,535.16,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","PSMD1","ENSG00000173692","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Neutrophil degranulation","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",9045.2,9271.2,9651.2,9072.2,9569.7,9314.8,1.0003898886492328,5.6238079492558772E-4,0.988038232053031,0.005226250100211486,0.9927425705662162,0.003163354401746852,7771]
["High","Q99487","Platelet-activating factor acetylhydrolase 2, cytoplasmic [OS=Homo sapiens]",12,3,4,3,392,44,6.89,9.99,"other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PAFAH2","ENSG00000158006","","Platelet homeostasis","Ether lipid metabolism; Metabolic pathways",57.8,64.9,56.8,74.9,65.2,67.7,0.8638113570741097,-0.2112118101937981,0.07126275664701787,1.1471373819087667,0.23068806131837294,0.6369748807182448,2412]
["High","Q99538","Legumain [OS=Homo sapiens]",17,5,17,5,433,49.4,6.55,39.85,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","LGMN","ENSG00000100600","","MHC class II antigen presentation; Trafficking and processing of endosomal TLR; Vitamin D (calciferol) metabolism","Lysosome; Antigen processing and presentation",616.6,672.6,642.9,502,488.4,525.9,1.2742201411330212,0.3496145468912955,0.002085866710458186,2.680713446993855,0.03787545877966864,1.4216420979148061,430]
["High","Q99570","Phosphoinositide 3-kinase regulatory subunit 4 [OS=Homo sapiens]",15,14,32,14,1358,153,7.17,45.52,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIK3R4","ENSG00000196455","Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Ciliopathies; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; DNA damage response (only ATM dependent)","PI3K Cascade; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade","Autophagy; Autophagy; Apelin signaling pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis",875,882.4,957.8,805,914.7,861.7,1.0518323390408304,0.07290475889702346,0.34061234135854995,0.4677396203581033,0.5726746686751847,0.24209202676600416,4644]
["High","Q99611","Selenide, water dikinase 2 [OS=Homo sapiens]",9,2,5,2,448,47.3,5.88,5.26,"other metabolic processes","cytosol;other cell component","kinase activity;other molecular function","SEPHS2","ENSG00000179918","Selenium micronutrient network","Selenocysteine synthesis","Selenocompound metabolism; Metabolic pathways",18.6,19.2,12.9,23.6,12.9,21.7,0.8711340206185565,-0.19903340590494373,0.552417065134478,0.2577329137659958,0.747404686288339,0.12644418341602306,5771]
["High","Q99614","tetratricopeptide repeat protein 1 [OS=Homo sapiens]",48,11,22,11,292,33.5,4.84,48.22,"other biological processes","cytosol","other molecular function","TTC1","ENSG00000113312","","","",1129.3,1252.5,1082.8,1591.2,1078.1,998.6,0.9445731890182394,-0.08226550860423479,0.7425564471840083,0.1292705268339976,0.8693778287018649,0.060791439594015215,6669]
["High","Q99666","RANBP2-like and GRIP domain-containing protein 5/6 [OS=Homo sapiens]",22,37,115,1,1765,198.8,6.42,239.39,"transport;other biological processes","nucleus;other cell component","","RGPD5; RGPD6","ENSG00000015568; ENSG00000183054","","","",147.6,145.7,148.6,201.9,210.3,204.7,0.7163235532501214,-0.4813167151735189,2.3790998864684186E-5,4.623587323733486,6.405521349498418E-3,2.1934455169738065,29]
["High","Q99707","methionine synthase [OS=Homo sapiens]",7,7,10,7,1265,140.4,5.58,16.9,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol","other molecular function","MTR","ENSG00000116984","Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Vitamin B12 disorders; Male infertility","RHOH GTPase cycle; Cobalamin (Cbl, vitamin B12) transport and metabolism; Methylation; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG","Cysteine and methionine metabolism; Selenocompound metabolism; One carbon pool by folate; Metabolic pathways; Biosynthesis of amino acids",217.2,232.7,221.3,244.8,222.1,236.3,0.9544937428896474,-0.06719235470358072,0.25744498594846527,0.5893155621630966,0.48624345676962183,0.31314622979573065,4134]
["High","Q99732","Lipopolysaccharide-induced tumor necrosis factor-alpha factor [OS=Homo sapiens]",4,1,2,1,161,17.1,6.44,4.15,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","LITAF","ENSG00000189067","Intracellular trafficking proteins involved in CMT neuropathy","","Lysosome",206.1,208.2,206.6,237.1,248.2,243.2,0.852299245024022,-0.23056804059320693,3.9320941618461444E-4,3.405376090666825,0.017954263868827307,1.7458323964003435,171]
["High","Q99807-1","5-demethoxyubiquinone hydroxylase, mitochondrial [OS=Homo sapiens]",13,2,2,2,217,24.3,8.59,3.09,"other metabolic processes;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","COQ7","ENSG00000167186","","Ubiquinol biosynthesis","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",41,43.1,42,44.5,49.4,51.6,0.8666666666666666,-0.20645087746742652,0.041532228650729835,1.3816147636952092,0.17166947660396958,0.7653069169584075,1889]
["High","Q99816","tumor susceptibility gene 101 protein [OS=Homo sapiens]",22,10,28,10,390,43.9,6.46,63.9,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TSG101","ENSG00000074319","Ebola virus infection in host; 7q11.23 copy number variation syndrome","HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy","Endocytosis",1482.5,1552.3,1486,1607.9,1565.3,1549.7,0.9572084947807492,-0.06309489470581074,0.07806113429870523,1.107565142318293,0.24448509290184134,0.6117476161634312,2493]
["High","Q99933","BAG family molecular chaperone regulator 1 [OS=Homo sapiens]",26,7,13,7,345,38.8,7.81,33.93,"signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","other molecular function","BAG1","ENSG00000107262","Androgen receptor signaling pathway","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",461.7,480,484.1,486.5,506.4,456.2,0.9839210544475883,-0.023385530263941422,0.655462948833295,0.18345185252008833,0.8140376498314567,0.08935550821164036,6287]
["High","Q9BPU6","Dihydropyrimidinase-related protein 5 [OS=Homo sapiens]",35,14,40,14,564,61.4,7.2,122.07,"cell organization and biogenesis;developmental processes;signal transduction","cytosol;other cell component","cytoskeletal activity;other molecular function","DPYSL5","ENSG00000157851","","CRMPs in Sema3A signaling","Axon guidance",1646,1581.7,1622,1667.9,1640,1677.6,0.9727610069200682,-0.039842695310760665,0.10742155496832001,0.9689085653353732,0.29409098919798127,0.5315182818565657,2852]
["High","Q9BPX5","actin-related protein 2/3 complex subunit 5-like protein [OS=Homo sapiens]",50,6,10,6,153,16.9,6.6,27.79,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity","ARPC5L","ENSG00000136950","Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling pathway","","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",190.1,149.1,149.1,204.1,149.2,162,0.9476033378614399,-0.07764481451556536,0.696864457296278,0.15685168556438778,0.8405866959013345,0.07541748792368279,6473]
["High","Q9BQ69","O-acetyl-ADP-ribose deacetylase MACROD1 [OS=Homo sapiens]",9,3,4,3,325,35.5,9.51,2.4,"protein metabolism;other metabolic processes;stress response","nucleus","other molecular function","MACROD1","ENSG00000133315","","","",140.6,143.8,140.4,132.5,135.3,125,1.0814663951120163,0.1129888364894605,0.0309107904245063,1.509889889384692,0.14495582680753463,0.8387643225683953,1665]
["High","Q9BQB6-1","vitamin K epoxide reductase complex subunit 1 [OS=Homo sapiens]",12,2,4,2,163,18.2,9.36,8.05,"protein metabolism;other metabolic processes;stress response;developmental processes","other membranes;ER/Golgi","other molecular function","VKORC1","ENSG00000167397; ENSPPAG00000037377; ENSPPYG00000007306; ENSPTRG00000008031","","Metabolism of vitamin K","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",336.6,327.1,376.6,341.8,346.4,369.5,0.9835492105511962,-0.02393085728741985,0.7558985323646088,0.12153649787399691,0.8761959235010193,0.05739877170695457,6736]
["High","Q9BQE5","apolipoprotein L2 [OS=Homo sapiens]",18,6,7,6,337,37.1,6.74,19.08,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","APOL2","ENSG00000128335","","","",622.3,531.6,538.7,578.6,581.7,625.4,0.9478635829086631,-0.07724865435334893,0.3977657974253081,0.40037256316246345,0.626034135516389,0.20340198554001362,4961]
["High","Q9BQP7","mitochondrial genome maintenance exonuclease 1 [OS=Homo sapiens]",24,7,16,7,344,39.4,7.68,32.53,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","mitochondrion","other molecular function","MGME1","ENSG00000125871","","","",885.4,896,971.5,1015.8,1006.9,1030.5,0.9016441766015985,-0.1493698919296944,0.023182085937044794,1.634847488554056,0.12313314761662977,0.9096250186435967,1470]
["High","Q9BQS8","fyve and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",4,5,5,5,1478,166.9,4.92,8.18,"transport;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FYCO1","ENSG00000163820","","","Salmonella infection",127.3,121.5,108.4,149.1,130.8,127,0.8778569673138364,-0.18794219995248745,0.13353573350324888,0.874402503687352,0.33450337093146204,0.4755995013055564,3117]
["High","Q9BRG1","Vacuolar protein-sorting-associated protein 25 [OS=Homo sapiens]",30,3,5,3,176,20.7,6.34,5.87,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS25","ENSG00000131475","","HCMV Late Events; Endosomal Sorting Complex Required For Transport (ESCRT)","Endocytosis",90.4,87.7,95.1,107.6,116.6,113.4,0.8092417061611374,-0.3053574204170947,0.003245428112723814,2.4887280061887296,0.04615719982540536,1.3357605459801862,549]
["High","Q9BRP8","Partner of Y14 and mago [OS=Homo sapiens]",27,4,5,4,204,22.6,9.45,10.55,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity","PYM1","ENSG00000170473","","","Nucleocytoplasmic transport; mRNA surveillance pathway",103.4,77.5,77.2,108.5,88.7,74.9,0.9485483278206542,-0.07620681515570865,0.7388487230534618,0.13144447292921618,0.8672475690922173,0.061856908818062425,6652]
["High","Q9BRS8","La-related protein 6 [OS=Homo sapiens]",15,5,7,5,491,54.7,8.25,9.61,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity","LARP6","ENSG00000166173","","","",212.5,186.1,229.2,197.6,172,175.9,1.1508707607699358,0.20272583237114555,0.13861772307729456,0.858181239113857,0.34078311769128333,0.46752192821028027,3176]
["High","Q9BRT9","DNA replication complex GINS protein SLD5 [OS=Homo sapiens]",34,6,14,6,223,26,4.98,27.89,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes","nucleus;other cell component","","GINS4","ENSG00000147536","","Unwinding of DNA","",647.8,577.5,593.3,643.9,573.8,574.3,1.01484375,0.021257620560518803,0.7926389018798046,0.10092461676446254,0.8946118164032255,0.048365369784169804,6918]
["High","Q9BS26","Endoplasmic reticulum resident protein 44 [OS=Homo sapiens]",47,18,54,18,406,46.9,5.26,119.58,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","ERP44","ENSG00000023318","","Neutrophil degranulation","",2358.3,2382.5,2432.4,2296.8,2288.6,2267,1.0468157142023236,0.06600748657883213,0.010501474548618595,1.9787497158475218,0.08315974977242797,1.0800868261300975,986]
["High","Q9BSD7","Cancer-related nucleoside-triphosphatase [OS=Homo sapiens]",72,11,29,11,190,20.7,9.54,77.55,"","","other molecular function","NTPCR","ENSG00000135778","","","Purine metabolism; Thiamine metabolism; Metabolic pathways",1354.5,1308.7,1394.3,1405.6,1486.1,1396.2,0.9462674036241517,-0.07968016568979816,0.11169062212245075,0.9519832900128365,0.3017579161010711,0.520341328110749,2890]
["High","Q9BSJ2-1","Gamma-tubulin complex component 2 [OS=Homo sapiens]",12,10,14,10,902,102.5,6.84,32.13,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","TUBGCP2","ENSG00000130640","15q11.2 copy number variation syndrome","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","",493.6,503.2,508.8,542.8,557.7,571.1,0.9006939459200766,-0.15089113059387238,0.004004761793188211,2.397423311035563,0.05019130029087247,1.2993715530360972,623]
["High","Q9BSQ5-1","Cerebral cavernous malformations 2 protein [OS=Homo sapiens]",16,5,5,5,444,48.8,5.54,5.73,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","mitochondrion;other cell component","","CCM2","ENSG00000136280","","","",247.9,225.9,199.1,193.3,210.8,221.1,1.076295585412668,0.10607434280776401,0.38395699926461346,0.4157174111215228,0.6128242539366521,0.2126640548271352,4892]
["High","Q9BSY9","Desumoylating isopeptidase 2 [OS=Homo sapiens]",35,3,17,3,194,21.4,4.92,29.12,"protein metabolism;other metabolic processes","other cell component","other molecular function","DESI2","ENSG00000121644","","","",619.8,635,670.8,596.3,566.1,578.6,1.1060310166570935,0.14539184393603324,0.024412534176905854,1.61238713570281,0.12648511403668275,0.8979605833588064,1507]
["High","Q9BT67","NEDD4 family-interacting protein 1 [OS=Homo sapiens]",13,2,3,2,221,24.9,4.68,7.2,"protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","NDFIP1","ENSG00000131507","","","",93.8,93.3,97.9,117,128.2,136.6,0.746464117338921,-0.42185518346447104,0.005310449375811581,2.2748687269076733,0.05774928791968917,1.2384533664913382,718]
["High","Q9BTC0","Death-inducer obliterator 1 [OS=Homo sapiens]",27,44,105,44,2240,243.7,7.88,264.18,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytoskeleton;nucleus;other cell component","other molecular function","DIDO1","ENSG00000101191","","","",4078.5,4208.2,4165.3,4512.4,4161.4,4443.5,0.9492807208800592,-0.07509331139944397,0.1234997593117633,0.9083338887984443,0.31961754083733773,0.4953693943147973,3017]
["High","Q9BTE7","DCN1-like protein 5 [OS=Homo sapiens]",30,6,13,6,237,27.5,5.58,16.27,"protein metabolism;other metabolic processes;stress response;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","DCUN1D5","ENSG00000137692","","Neddylation","",530,481.9,423.3,563.1,429.2,465.7,0.9843621399176955,-0.022738924295038185,0.8876292625126049,0.05176838879889927,0.9431966904869923,0.02539773177403456,7348]
["High","Q9BTV4","Transmembrane protein 43 [OS=Homo sapiens]",30,13,47,13,400,44.8,8.13,116.42,"cell organization and biogenesis","other membranes;ER/Golgi;nucleus","other molecular function","TMEM43","ENSG00000170876","Envelope proteins and their potential roles in EDMD physiopathology","","",2272.8,2266.3,2382.6,2088.6,2123.6,2194.3,1.0804183251385313,0.11159001493570746,0.024609111340055688,1.6089040688278096,0.12708197178780078,0.8959160553343619,1512]
["High","Q9BTZ2","dehydrogenase/reductase sdr family member 4 [OS=Homo sapiens]",11,2,2,2,278,29.5,8.56,7.68,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","DHRS4","ENSG00000157326; ENSG00000284807","","Peroxisomal protein import; RA biosynthesis pathway","Retinol metabolism; Metabolic pathways; Peroxisome",122.5,119.1,140.4,119,124,123.9,1.0411556282365768,0.058185733674568335,0.5008425628249427,0.30029877082290063,0.7061355598658635,0.15111191757382095,5538]
["High","Q9BUB7","Transmembrane protein 70, mitochondrial [OS=Homo sapiens]",10,2,2,2,260,29,8.91,5.65,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","TMEM70","ENSG00000175606","","","",96.6,84.4,96.2,94.4,117.3,105.1,0.8750000000000001,-0.19264507794239571,0.16295657014490544,0.7879281247959209,0.3725812297778687,0.42877902815483687,3415]
["High","Q9BUI4","DNA-directed RNA polymerase III subunit RPC3 [OS=Homo sapiens]",37,14,21,14,534,60.6,7.31,42.06,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3C","ENSG00000186141","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",801.6,747.3,809.7,837,860.4,806.7,0.9418952917215766,-0.08636140714093848,0.12446606946872403,0.9049490248805181,0.32094817384801755,0.49356509104991786,3028]
["High","Q9BUP0","EF-hand domain-containing protein D1 [OS=Homo sapiens]",18,4,11,2,239,26.9,5.39,17.37,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","EFHD1","ENSG00000115468","","","",175.8,165.7,175,190.7,195.4,217.7,0.8554157005631003,-0.2253024077612033,0.03119001975461994,1.505984350176498,0.14487309592151842,0.8390122589573336,1681]
["High","Q9BV23","Monoacylglycerol lipase ABHD6 [OS=Homo sapiens]",8,2,2,2,337,38.3,8.41,2.68,"other metabolic processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ABHD6","ENSG00000163686","","Arachidonate production from DAG","Retrograde endocannabinoid signaling",39.4,37.1,34.9,42.2,27.6,44.7,0.9729257641921396,-0.03959836564427472,0.859825569994581,0.06558964372421648,0.9315274109223933,0.03080436112502331,7207]
["High","Q9BV68-2","Isoform 2 of E3 ubiquitin-protein ligase RNF126 [OS=Homo sapiens]",28,4,9,4,311,33.8,5.47,16.16,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","RNF126","ENSG00000070423; ENSPTRG00000010160","","Antigen processing: Ubiquitination & Proteasome degradation","",205.1,263.2,206.5,233.6,205.6,211.7,1.0367183899216468,0.05202405939867029,0.7229601127479078,0.14088566299778096,0.8576226922418207,0.06670373629750033,6582]
["High","Q9BVA0","Katanin p80 WD40 repeat-containing subunit B1 [OS=Homo sapiens]",25,13,22,13,655,72.3,7.56,54.32,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KATNB1","ENSG00000140854","Genes related to primary cilium development (based on CRISPR)","","",914.1,809.8,852.4,948.5,898.3,962.5,0.9170611896201901,-0.1249100960545734,0.09722049110270806,1.0122421894468556,0.2785679245981448,0.5550688914008813,2725]
["High","Q9BVG3","E3 ubiquitin-protein ligase TRIM62 [OS=Homo sapiens]",5,2,4,2,475,54.2,6.62,8.74,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","TRIM62","ENSG00000116525","","Interferon gamma signaling","",114.3,107.6,107.9,98.1,109.6,107.4,1.0466518565534748,0.06578164441992712,0.3027975252900509,0.5188476785684876,0.5352599224506944,0.27143527316824334,4417]
["High","Q9BVJ6-1","U3 small nucleolar RNA-associated protein 14 homolog A [OS=Homo sapiens]",26,19,39,19,771,87.9,7.87,77.94,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","UTP14A","ENSG00000156697","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1554.1,1562.7,1468.4,1548.9,1342.5,1494.5,1.0454410725278738,0.06411174507648375,0.38835325979526075,0.4107730450732366,0.6181982166119054,0.20887225213056848,4905]
["High","Q9BVM4","gamma-glutamylaminecyclotransferase [OS=Homo sapiens]",8,1,2,1,153,17.3,6.87,3.18,"other metabolic processes","cytosol","other molecular function","GGACT","ENSG00000134864","","","",89.9,89.6,81.9,86.5,83.7,93.9,0.9897765997728131,-0.014825160371660087,0.833576991862617,0.07905428114268574,0.9196791228576111,0.03636367208930823,7077]
["High","Q9BVV7","Mitochondrial import inner membrane translocase subunit TIM21 [OS=Homo sapiens]",12,3,4,3,248,28.2,9.7,0,"cell organization and biogenesis;transport","other membranes;mitochondrion","","TIMM21","ENSG00000075336","","Mitochondrial protein import","",73.9,68.8,78.1,73.2,70.2,74.6,1.0128440366972475,0.01841203711388011,0.7702033056768194,0.11339462173754015,0.8833354011052593,0.05387436415543623,6808]
["High","Q9BW71-1","HIRA-interacting protein 3 [OS=Homo sapiens]",11,6,8,6,556,61.9,8.54,20.65,"cell organization and biogenesis","nucleus","","HIRIP3","ENSG00000149929","22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome","","",398.7,354.4,376.6,436.3,388.2,417.6,0.9095080911359793,-0.13684162249731902,0.11934966887563472,0.923178781564509,0.3137650554144633,0.5033954262230859,2970]
["High","Q9BWE0","Replication initiator 1 [OS=Homo sapiens]",22,8,13,8,567,63.5,9.98,42.77,"other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","REPIN1","ENSG00000214022","","","",817.2,668.7,641.4,703.8,648.8,744.6,1.0143524699599467,0.020559051063543374,0.8778627203399909,0.056573393501905635,0.9379244828153598,0.027832127523770404,7308]
["High","Q9BWS9-1","Chitinase domain-containing protein 1 [OS=Homo sapiens]",24,7,12,7,393,44.9,8.63,16.38,"other metabolic processes;stress response;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle","other molecular function","CHID1","ENSG00000177830","","Platelet degranulation","",282.7,292.6,313.2,296.6,264.8,291.3,1.0419842852116805,0.059333519633562634,0.42099017343335843,0.3757280411559578,0.645033609530546,0.19041765582461645,5096]
["High","Q9BX66-12","Isoform 12 of Sorbin and SH3 domain-containing protein 1 [OS=Homo sapiens]",5,5,7,5,1294,143.7,8.6,11.95,"","","","SORBS1","","","","",337.8,328,300.2,284,283.6,287.5,1.129692433633493,0.17593004266726886,0.03099319028086968,1.5087337174017068,0.14482036487913252,0.8391703626364627,1671]
["High","Q9BXA9","sal-like protein 3 [OS=Homo sapiens]",7,7,7,6,1300,135.3,6.99,16.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SALL3","ENSG00000256463; ENSG00000277015","","","",286.4,319.2,259.1,332.5,296.8,307.6,0.9229373465684704,-0.11569538077897841,0.30216742763702104,0.5197523525711698,0.5347514222551814,0.2718480516806874,4412]
["High","Q9BXF6","Rab11 family-interacting protein 5 [OS=Homo sapiens]",10,5,7,5,653,70.4,9.23,14.76,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB11FIP5","ENSG00000135631","","","Endocytosis",274.9,281.1,284.4,312.1,284.7,299.2,0.9379464285714285,-0.0924225702719206,0.09172520229419333,1.0375113217616574,0.2691433218763854,0.5700163916544108,2661]
["High","Q9BXP5","serrate RNA effector molecule homolog [OS=Homo sapiens]",42,40,132,40,876,100.6,5.96,233.1,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SRRT","ENSG00000087087","","mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes","",6065.2,6038.6,5974,6492.4,6135.2,6577.3,0.9413118527042579,-0.08725533387265119,0.05299491149277999,1.27576582882751,0.19481368593956033,0.710380536578306,2124]
["Medium","Q9BXT8","Ring finger protein 17 [OS=Homo sapiens]",1,1,4,1,1623,184.5,5.4,0,"other biological processes","nucleus;other cell component","other molecular function","RNF17","ENSG00000132972","","","",136.4,103.2,218.3,147.1,222.9,154.2,0.8735215566577642,-0.19508478865487036,0.6256395300972992,0.20367581883446653,0.7946955345696619,0.09979922729668862,6147]
["High","Q9BY11","Protein kinase C and casein kinase substrate in neurons protein 1 [OS=Homo sapiens]",7,3,3,1,444,50.9,5.24,7.13,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","PACSIN1","ENSG00000124507","","Clathrin-mediated endocytosis","",26.5,20.9,21.2,32,22.7,23.5,0.877237851662404,-0.18896003113454013,0.4107591365129936,0.38641276777592626,0.6367296680352301,0.1960449139750021,5037]
["High","Q9BY77","Polymerase delta-interacting protein 3 [OS=Homo sapiens]",38,14,32,1,421,46.1,9.99,82.46,"other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","POLDIP3","ENSG00000100227","","mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",1066.6,1049.1,1077.6,1146,1147.9,1095.8,0.942059769301118,-0.08610949987005499,0.026029583562773195,1.5845327799444093,0.1307844198572285,0.8834439897506694,1554]
["High","Q9BYD2","39S ribosomal protein L9, mitochondrial [OS=Homo sapiens]",24,6,14,6,267,30.2,10.08,27.86,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL9","ENSG00000143436","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",517.5,526.7,495,542.6,530,480.2,0.9912416280267904,-0.012691318943621667,0.841501188835541,0.07494526613575016,0.9234632863566977,0.0345803658974179,7115]
["High","Q9BYG3","MKI67 FHA domain-interacting nucleolar phosphoprotein [OS=Homo sapiens]",41,10,39,10,293,34.2,9.88,97.72,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","NIFK","ENSG00000155438","","","",1736.5,1842.1,1907.8,1861.9,1969.3,1880.2,{"$f":"AVERAGE(T6146:V6146)/AVERAGE(W6146:Y6146)","v":0.960605105578317},{"$f":"LOG(Z6146,2)","v":-0.05798461842431573},{"$f":"TTEST(T6146:V6146,W6146:Y6146,2,2)","v":0.2788680395172781},{"$f":"-LOG10(AB6146)","v":0.5546012564641349},{"$f":"AB6146*7808/AF6146","v":0.5095721162066248},{"$f":"-LOG10(AD6146)","v":0.29279434462269605},4273]
["High","Q9BYK8-1","Helicase with zinc finger domain 2 [OS=Homo sapiens]",12,22,34,22,2649,294.5,7.49,66.93,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HELZ2","ENSG00000130589","","PPARA activates gene expression; Heme signaling; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); Transcriptional activation of mitochondrial biogenesis; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RORA activates gene expression","",752,762.7,792.4,626.5,632,662.8,1.2008015406235362,0.26399773304434837,1.4759225881478995E-3,2.8309364205765646,0.032280122039940615,1.4910648320301223,357]
["High","Q9BYV8","centrosomal protein of 41 kDa [OS=Homo sapiens]",14,3,6,3,373,41.3,8.32,12.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","cytosol;cytoskeleton;other cell component","","CEP41","ENSG00000106477","Joubert syndrome; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",96.1,91.5,91.7,117.1,125.3,105.8,0.8021252153934522,-0.318100629371151,0.017149571675079345,1.7657467223542995,0.1078999642538433,0.966978699194394,1241]
["High","Q9BZ29-4","Isoform 4 of Dedicator of cytokinesis protein 9 [OS=Homo sapiens]",1,2,2,2,2093,238.7,7.62,3.24,"","","","DOCK9","","","","",68.6,58.3,56.7,50.4,56.4,63.7,1.07683284457478,0.10679431950227293,0.46070089066772624,0.33658094812998846,0.6750145532620767,0.1706868637122648,5329]
["High","Q9BZE2","tRNA pseudouridine(38/39) synthase [OS=Homo sapiens]",9,4,5,4,481,55.6,7.49,12.14,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PUS3","ENSG00000110060","","tRNA modification in the nucleus and cytosol","",278.9,227.6,250.1,286,286,257,0.9126658624849218,-0.13184132533373646,0.2447857549846295,0.611213859041082,0.4750900260800366,0.32322408695370797,4023]
["High","Q9BZH6","WD repeat-containing protein 11 [OS=Homo sapiens]",13,13,29,13,1224,136.6,6.92,55.92,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","WDR11","ENSG00000120008","","RHOH GTPase cycle","",1109.3,919.5,1312.1,977.3,1293.3,1011.6,1.017884345865578,0.025573648717184903,0.9032998736705157,0.04416805050509821,0.9509188908749342,0.021856524858257207,7417]
["High","Q9BZK7","F-box-like/WD repeat-containing protein TBL1XR1 [OS=Homo sapiens]",27,9,24,6,514,55.6,5.55,55.77,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1XR1","ENSG00000177565","Rett syndrome causing genes","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Heme signaling; HCMV Early Events; HDACs deacetylate histones; Transcriptional activation of mitochondrial biogenesis; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity","Wnt signaling pathway",688.1,756.7,674.5,777.6,771.4,785.7,0.9077397524307194,-0.13964935650559426,0.04952002007297706,1.3052191879463106,0.1876042293691436,0.7267573750668881,2061]
["High","Q9BZV1","UBX domain-containing protein 6 [OS=Homo sapiens]",18,4,8,4,441,49.7,6.89,16.25,"protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","","UBXN6","ENSG00000167671","","","Protein processing in endoplasmic reticulum",103,113.4,125.6,130.9,132.6,130.3,0.8684611477907567,-0.20346678612829358,0.05823264482464912,1.2348334845499538,0.20499571271003622,0.6882552217044597,2218]
["High","Q9C0B7","Transport and Golgi organization protein 6 homolog [OS=Homo sapiens]",13,9,13,9,1094,120.7,6.11,31.53,"transport","other membranes","","TANGO6","ENSG00000103047","","","",456,461.6,441.6,494,436.9,456.8,0.9794624198313756,-0.02993795488351976,0.6211072770113744,0.2068333824476213,0.7906106323613974,0.10203734943545256,6134]
["High","Q9C0C2","182 kDa tankyrase-1-binding protein [OS=Homo sapiens]",59,72,216,72,1729,181.7,4.86,497.34,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TNKS1BP1","ENSG00000149115","Ciliary landscape","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",8200.3,7980.5,7977,8873.8,7626.8,7865.2,0.9914634446642424,-0.012368513733122583,0.8672860599434699,0.06183763405275878,0.9332648230483204,0.029995103446162224,7256]
["High","Q9C0H2-1","Protein tweety homolog 3 [OS=Homo sapiens]",7,4,14,4,523,57.5,5.39,35.23,"transport","plasma membrane;other membranes","transporter activity","TTYH3","ENSG00000136295","","Stimuli-sensing channels","",454.2,482.9,470.4,393.7,371.3,407.6,1.200324066177725,0.26342396045848154,4.3326928889076185E-3,2.363242093651907,0.0518065330422522,1.285615470268346,653]
["High","Q9C0J8","pre-mRNA 3' end processing protein WDR33 [OS=Homo sapiens]",18,19,34,19,1336,145.8,9.17,53.9,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","WDR33","ENSG00000136709","","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",1419.6,1376,1447.2,1813.7,1478,1626,0.8627610468308355,-0.21296705377680822,0.08619697042060939,1.0645079981281136,0.25875661093583935,0.587108545665351,2601]
["High","Q9GZP9","Derlin-2 [OS=Homo sapiens]",16,2,5,2,239,27.5,7.28,13.02,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","DERL2","ENSG00000072849","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",81.5,66.8,74.1,72.2,69.8,72.5,1.036829836829837,0.0521791403365997,0.5758126238841029,0.23971881805622133,0.7624122379662669,0.11781014117539249,5897]
["High","Q9GZT4","serine racemase [OS=Homo sapiens]",9,2,4,2,340,36.5,6.54,5.29,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","SRR","ENSG00000167720","Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; D-Amino acid metabolism; Metabolic pathways",61.2,71.1,57.2,54,52.4,62.1,1.1246290801186944,0.16944925698923335,0.24236541019162516,0.615529361547087,0.47286085026891783,0.3252666411886443,4002]
["High","Q9GZU8","Protein FAM192A [OS=Homo sapiens]",27,6,10,6,254,28.9,5.45,17.06,"other biological processes","nucleus","","PSME3IP1","ENSG00000172775","","","",501.4,482.7,475,792,523,505.7,0.801395067831054,-0.31941446412735586,0.264747048736456,0.5771688724843707,0.49536183957207003,0.3050774525374441,4173]
["High","Q9GZY8-1","Mitochondrial fission factor [OS=Homo sapiens]",28,5,10,5,342,38.4,8.95,19.97,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","C2orf33; MFF","ENSG00000168958","","","",98,93.3,101,111.9,106.1,93.2,0.93926735218509,-0.09039223118013912,0.35034697275504517,0.4555016307648378,0.5827671843356184,0.23450491136877616,4694]
["High","Q9H019-1","Mitochondrial fission regulator 1-like [OS=Homo sapiens]",25,5,12,5,292,31.9,6.1,27.63,"cell organization and biogenesis;other metabolic processes","mitochondrion","","FAM54B; MTFR1L","ENSG00000117640; ENSPPAG00000030443","","","",330.4,330.4,300.3,317.7,261.9,252.2,1.1554460206780475,0.20844986255834833,0.13097290339467188,0.8828185449808954,0.3303089243235136,0.4810796923331149,3096]
["High","Q9H089","Large subunit GTPase 1 homolog [OS=Homo sapiens]",24,14,30,14,658,75.2,6.38,64.71,"transport","cytosol;ER/Golgi;nucleus","other molecular function","LSG1","ENSG00000041802","","","Ribosome biogenesis in eukaryotes",1190.6,1260.9,1235.4,1234,1249.4,1300.5,0.9743650730727557,-0.037465675321107776,0.323547564446712,0.49006186504694915,0.5563222601189005,0.25467356228928045,4541]
["High","Q9H0A8-1","COMM domain-containing protein 4 [OS=Homo sapiens]",37,6,8,6,199,21.8,7.31,22.09,"","plasma membrane;other membranes;cytosol;nucleus;other cell component","","COMMD4","ENSG00000140365; ENSGGOG00000014844","","Neddylation","",284.2,253.7,333.3,258.3,386.3,323.5,0.8999070343972732,-0.15215212449119117,0.5001584410415798,0.3008923973239241,0.7055532263148429,0.15147021788003026,5535]
["High","Q9H0G5","Nuclear speckle splicing regulatory protein 1 [OS=Homo sapiens]",20,9,13,9,558,66.4,8.84,21.21,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","NSRP1","ENSG00000126653","","","",583.9,605.6,586.5,708.2,700.9,697.8,0.8429446105652857,-0.24649025931685647,1.2464830401424649E-4,3.904313626203649,0.011186827100496973,1.9512930741636323,87]
["High","Q9H0Q0","Protein FAM49A [OS=Homo sapiens]",18,4,5,4,323,37.3,6.01,9.92,"cell organization and biogenesis","other membranes","other molecular function","CYRIA","ENSG00000197872","","","",112.3,108.4,105.2,91.7,88.4,84,1.234002271866717,0.30334505057147104,2.4489413819825763E-3,2.61102161005135,0.04068369002238288,1.390579663328432,470]
["High","Q9H0R8-1","Gamma-aminobutyric acid receptor-associated protein-like 1 [OS=Homo sapiens]",13,2,4,1,117,14,8.73,6.43,"cell organization and biogenesis;other metabolic processes;stress response","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","gabarapl1; Gabarapl1; GABARAPL1; gabarapl1.L; GBRL1; LOC101346525; LOC110090845; LOC111142199; LOC113417224; LOC113444478; LOC113982994","ENSACUG00000002920; ENSAMEG00000026339; ENSANAG00000017627; ENSBIXG00000025666; ENSBIXG00005000420; ENSBMUG00000009257; ENSBTAG00000011765; ENSCAFG00000013479; ENSCANG00000037817; ENSCATG00000043779; ENSCCAG00000031173; ENSCGRG00001022681; ENSCGRG00015025519; ENSCHIG00000025179; ENSCJAG00000048408; ENSCPOG00000006718; ENSCPRG00005001116; ENSCSAG00000009078; ENSFCAG00000022695; ENSG00000139112; ENSGAGG00000013450; ENSGALG00000014723; ENSGGOG00000022360; ENSLCNG00005007852; ENSLSDG00000014620; ENSMFAG00000037621; ENSMGAG00000014228; ENSMLEG00000037692; ENSMMUG00000002197; ENSMNEG00000040661; ENSMODG00000018255; ENSMUSG00000030161; ENSNLEG00000029077; ENSNVIG00000010216; ENSOGAG00000000859; ENSPANG00000015789; ENSPCLG00000013759; ENSPPAG00000035460; ENSPSIG00000008179; ENSPTRG00000052409; ENSPTXG00000014934; ENSRBIG00000038034; ENSRFEG00010012750; ENSRNOG00000053362; ENSRROG00000036376; ENSSBOG00000023150; ENSSHBG00005010614; ENSSTOG00000002246; ENSTGUG00000029032; ENSTMTG00000017402; ENSTSYG00000033601; ENSTTRG00000009099; ENSUAMG00000018185; ENSUMAG00000016270; ENSVVUG00000005149; ENSXETG00000016242","Senescence and autophagy in cancer","Macroautophagy; Macroautophagy; Macroautophagy; Macroautophagy; Macroautophagy","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse",150,85.4,103.2,114.5,118,103.9,1.0065398335315103,0.009404267640497793,0.9721252237952684,0.012277788056838197,0.9842263676599398,0.00690500429297719,7712]
["High","Q9H0W5","Coiled-coil domain-containing protein 8 [OS=Homo sapiens]",16,5,6,5,538,59.3,8.63,10.27,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","CCDC8","ENSG00000169515","","Neddylation","",252.8,164.1,198.5,241.5,229.5,219.6,0.8911091804228206,-0.16632589051984203,0.39911652092445826,0.39890029477216016,0.626266437977928,0.2032408617962871,4976]
["High","Q9H0W9","Ester hydrolase C11orf54 [OS=Homo sapiens]",23,6,12,6,315,35.1,6.7,21.13,"","nucleus","other molecular function","C11orf54","ENSG00000182919","","","",426.2,384.1,418,460.7,448.2,438.5,0.9116075404482706,-0.13351523684587402,0.051000809027967345,1.2924229346158849,0.19053316597625314,0.7200294160683034,2090]
["High","Q9H1C4","Protein unc-93 homolog B1 [OS=Homo sapiens]",4,2,2,2,597,66.6,6.96,3.23,"stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding","UNC93B1","ENSG00000110057","","Trafficking and processing of endosomal TLR; UNC93B1 deficiency - HSE","",44.7,39,43.8,46.4,38.9,42.1,1.000784929356358,1.1319694899199976E-3,0.9910780118429543,3.892159057145086E-3,0.9943892465265726,0.002443580866233368,7782]
["High","Q9H1K0","Rabenosyn-5 [OS=Homo sapiens]",8,6,8,6,784,88.8,5.5,18.35,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RBSN","ENSG00000131381","","Factors involved in megakaryocyte development and platelet production; Toll Like Receptor 9 (TLR9) Cascade","Endocytosis",399.8,364.6,383.9,419.2,415.6,401.2,0.9290453074433658,-0.10617913958192524,0.06486273103538412,1.1880047693752396,0.21708024171636486,0.6633797035103567,2333]
["Low","Q9H211","DNA replication factor Cdt1 [OS=Homo sapiens]",1,1,1,1,546,60.4,9.77,1.75,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CDT1","ENSG00000167513","Retinoblastoma gene in cancer; DNA replication","Orc1 removal from chromatin; Activation of the pre-replicative complex; CDT1 association with the CDC6:ORC:origin complex; G1/S-Specific Transcription","",20.9,20.9,22.4,43.1,27.9,33.6,0.6137667304015295,-0.7042376491246385,0.03922265928245792,1.4064629646573956,0.1663500943386374,0.778976948502775,1841]
["High","Q9H2D6","TRIO and F-actin-binding protein [OS=Homo sapiens]",9,16,28,16,2365,261.2,8.48,54.26,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TRIOBP","ENSG00000100106","","","",1004.2,954.1,937.3,989.8,1023.3,1009.7,0.9579198094481939,-0.06202320651848962,0.1303531484852703,0.8848784746355394,0.32938426646375096,0.48229714940173857,3090]
["High","Q9H2H8-1","peptidyl-prolyl cis-trans isomerase-like 3 [OS=Homo sapiens]",37,7,28,7,161,18.1,6.79,42.36,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","CLK1; LOC111141199; PPIL3","ENSAMEG00000005917; ENSCAFG00000011929; ENSECAG00000019985; ENSFCAG00000005373; ENSG00000240344; ENSGGOG00000022268; ENSOCUG00000010661; ENSPPAG00000039183; ENSPPYG00000013062; ENSPTRG00000012793; ENSRFEG00010017851; ENSSSCG00000016096; ENSSSCG00070023158; ENSSSUG00005004462; ENSSTOG00000028255; ENSUMAG00000021460","mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","",1010.5,1000.6,1021.4,1111.6,1092.1,1148.1,0.9047377528492154,-0.14442842146699023,0.00367623022067998,2.434597299124833,0.04848649588356298,1.3143792011891176,592]
["High","Q9H2S1-1","Small conductance calcium-activated potassium channel protein 2 [OS=Homo sapiens]",2,1,1,1,579,63.7,9.52,2.44,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;cytoskeletal activity;other molecular function","KCNN2","ENSG00000080709","Brain-derived neurotrophic factor (BDNF) signaling pathway","Ca2+ activated K+ channels; Acetylcholine inhibits contraction of outer hair cells","Serotonergic synapse; Insulin secretion; GnRH secretion; Bile secretion",18.8,22.2,23.2,19.9,16.1,22.6,1.0955631399317407,0.1316726327000554,0.46403570495494295,0.333448601625453,0.6781191810384044,0.1686939711497235,5343]
["High","Q9H329","Band 4.1-like protein 4B [OS=Homo sapiens]",4,4,14,1,900,99.7,9.04,16,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","EPB41L4B","ENSG00000095203","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","Tight junction",154.3,159.9,144.9,250.9,225.5,226.4,0.6532441661923734,-0.6143057592960101,9.8664045796362926E-4,3.0058410799238486,0.02781115052628165,1.5557810443296616,277]
["High","Q9H3C7","Gametogenetin-binding protein 2 [OS=Homo sapiens]",4,2,2,2,697,79,6.38,3.02,"developmental processes;other biological processes","nucleus;other cell component","","GGNBP2","ENSG00000275099; ENSG00000278311","","","",138.6,145,127.2,163.5,157.4,148.5,0.8751597784405625,-0.1923816602049751,0.04510455992127747,1.3457795501721057,0.17968183870680332,0.7454958168699465,1960]
["High","Q9H3K6-1","bola-like protein 2 [OS=Homo sapiens]",29,2,4,2,86,10.1,6.52,6.85,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","BOLA2; BOLA2B","ENSG00000169627; ENSG00000183336","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",127.8,121.4,114.3,153.3,128.1,119.7,0.9062577910745451,-0.14200660200755216,0.3112574245561658,0.5068802803610553,0.5455214300638703,0.26318818407531347,4455]
["High","Q9H3P2-1","Negative elongation factor A [OS=Homo sapiens]",39,14,43,14,528,57.2,9.03,96.4,"developmental processes;other biological processes","cytosol;nucleus","other molecular function","NELFA","ENSG00000185049","Initiation of transcription and translation elongation at the HIV-1 LTR","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1545.8,1533.3,1517.6,1693.2,1513.6,1581.3,0.9600258975376453,-0.05885477056899772,0.2950298167371268,0.5301340904963024,0.5275000707770748,0.2777774777590072,4367]
["High","Q9H3Z4","DnaJ homolog subfamily C member 5 [OS=Homo sapiens]",20,4,12,4,198,22.1,5.07,29.22,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","DNAJC5","ENSG00000101152","","Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; GABA synthesis, release, reuptake and degradation","Protein processing in endoplasmic reticulum",684.7,666.7,649.1,555.3,576.7,558.6,1.1833077014077844,0.2428252736547146,1.0803066650784084E-3,2.9664529444701513,0.028986372649251593,1.537806128797423,291]
["High","Q9H479","fructosamine-3-kinase [OS=Homo sapiens]",15,5,7,5,309,35.1,7.55,16.94,"protein metabolism;other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","FN3K","ENSG00000167363","","Gamma carboxylation, hypusine formation and arylsulfatase activation","",232.1,205.1,236.2,281.6,240.7,268.6,0.8514350739663674,-0.23203157324894905,0.06505590527608582,1.1867132753911576,0.21754026055489423,0.6624603556346531,2335]
["High","Q9H4B6","Protein salvador homolog 1 [OS=Homo sapiens]",20,6,10,6,383,44.6,9.09,16.57,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SAV1","ENSG00000151748","Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma","Signaling by Hippo","Hippo signaling pathway; Hippo signaling pathway",325.3,289.6,287.5,288.7,263.1,264.1,1.106017894349798,0.14537472723706135,0.12413837440017145,0.9060939460269694,0.3207387251212901,0.4938486013713405,3022]
["High","Q9H4G0-1","Band 4.1-like protein 1 [OS=Homo sapiens]",19,13,26,12,881,98.4,5.62,53.71,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","EPB41L1","ENSG00000088367","Splicing factor NOVA regulated synaptic proteins","Trafficking of AMPA receptors; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Neurexins and neuroligins","",628.5,622.3,662.9,680.7,656.8,679.9,0.9485972043223951,-0.07613247833178187,0.0806133200387515,1.0935931921728426,0.24888446139287138,0.604002216858612,2529]
["High","Q9H4M3-2","Isoform 2 of F-box only protein 44 [OS=Homo sapiens]",13,2,2,2,224,25.7,7.88,5.88,"","","","FBXO44","","","","",56.7,46.1,48.4,55.3,45.5,55.2,0.9692307692307693,-0.04508788952853787,0.7441576787671627,0.12833503251459585,0.8700783401937715,0.06044164257431239,6678]
["High","Q9H501","ESF1 homolog [OS=Homo sapiens]",25,19,44,19,851,98.7,5.11,98.45,"RNA metabolism OR transcription;other metabolic processes","nucleus","","ESF1","ENSG00000089048","","","",2328.4,2253.3,2340.6,2699.4,2509.8,2605.6,0.885793622357578,-0.17495748491432267,0.008254638994253759,2.0833019152820866,0.07225585343849031,1.1411269649995743,892]
["High","Q9H5L6","DNA transposase THAP9 [OS=Homo sapiens]",2,2,2,2,903,103.3,9.13,3.01,"DNA metabolism;other metabolic processes","","nucleic acid binding activity;other molecular function","THAP9","ENSG00000168152","","","",68.4,64.7,55.6,43.6,42.7,54,1.344975053456878,0.42757941398054616,0.037281720422174494,1.4285040546706043,0.16118254322056394,0.7926819959894558,1806]
["High","Q9H6A9-1","Pecanex-like protein 3 [OS=Homo sapiens]",3,3,4,3,2034,221.9,6.64,8.04,"","other membranes","","PCNX3","ENSG00000197136","","","",285.5,267,303,234.1,237.6,240,1.202051426162709,0.26549861874697106,0.010414404717066795,1.9823655490942094,0.0827219450975153,1.0823792622677095,983]
["High","Q9H6E4","Coiled-coil domain-containing protein 134 [OS=Homo sapiens]",20,4,12,4,229,26.5,8.85,30.41,"developmental processes","non-structural extracellular;ER/Golgi;nucleus","","CCDC134","ENSG00000100147","","","",411.5,434.2,430.6,411.5,453.8,418.7,0.9940031152647977,-0.008677721600774886,0.8711194634291786,0.059922282707141165,0.9345563026181679,0.029394529298722383,7278]
["High","Q9H6S0","Probable ATP-dependent RNA helicase YTHDC2 [OS=Homo sapiens]",7,6,9,6,1430,160.1,8.4,14.29,"cell cycle OR cell proliferation;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","YTHDC2","ENSG00000047188","","","",269.9,242.1,248.4,291.2,313.2,289.3,0.8508448025064338,-0.23303209232213443,0.017505878630105914,1.7568160868623586,0.10908691168704468,0.9622273531978732,1253]
["High","Q9H6S3","epidermal growth factor receptor kinase substrate 8-like protein 2 [OS=Homo sapiens]",6,4,4,4,715,80.6,6.84,8.54,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","cytoskeletal activity","EPS8L2","ENSG00000177106","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",191.7,202.2,204.8,252.3,211.3,236.5,0.8551635480645623,-0.22572773638846838,0.054992271155760226,1.2596983437833689,0.19860298482154293,0.702014228742025,2162]
["High","Q9H6Z4-2","Isoform 2 of Ran-binding protein 3 [OS=Homo sapiens]",36,14,47,14,562,59.7,4.81,105.84,"","","","RANBP3","","","","",1753.9,1574,1676,1847.5,1762.9,1672.9,0.9471163855923379,-0.07838637394575916,0.2682078686294502,0.5715284850518256,0.49872994481037075,0.3021345550311299,4199]
["High","Q9H7H0","Methyltransferase-like protein 17, mitochondrial [OS=Homo sapiens]",5,2,2,2,456,50.7,9.33,5.01,"protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus","other molecular function","METTL17","ENSG00000165792","","","",54.9,61.1,63.4,64.9,67.5,66.1,0.9037783375314862,-0.14595911711105888,0.0739512804616355,1.1310543018211365,0.2359671425600531,0.6271484665142903,2447]
["High","Q9H7L9","Sin3 histone deacetylase corepressor complex component SDS3 [OS=Homo sapiens]",16,5,8,5,328,38.1,5.66,18.91,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","SUDS3","ENSG00000111707","","Ub-specific processing proteases; NoRC negatively regulates rRNA expression; HDACs deacetylate histones; Potential therapeutics for SARS","",205.4,178.2,178.3,268.5,218.9,202.2,0.8148201856148495,-0.29544637412489605,0.12346802683169052,0.9084454923503388,0.3196413638931829,0.4953370248894398,3016]
["Medium","Q9H816","5' exonuclease Apollo [OS=Homo sapiens]",2,1,1,1,532,60,8.41,0,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DCLRE1B","ENSG00000118655","","Fanconi Anemia Pathway","",75.4,73.8,79.4,80.2,80.1,84.7,0.9330612244897959,-0.09995634567545472,0.07223265346768801,1.141266431031885,0.23286232794207598,0.6329007651802829,2422]
["High","Q9H8E8-1","Cysteine-rich protein 2-binding protein [OS=Homo sapiens]",9,6,6,6,782,88.8,6.57,14.23,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","KAT14","ENSG00000149474","","HATs acetylate histones","",260,249,257.1,241.2,283.6,247.6,0.9918436043500778,-0.011815443041935231,0.8847707366902472,0.05316924985505895,0.9422108445277483,0.025851901486602588,7332]
["High","Q9H8G2-1","Caspase activity and apoptosis inhibitor 1 [OS=Homo sapiens]",25,6,14,6,361,38.3,4.72,35.38,"other biological processes","","","CAAP1","ENSG00000120159","Acute viral myocarditis","","",351.5,354.2,356.6,362.4,370.2,383.9,0.9514554411106136,-0.07179200159776328,0.0488526399465715,1.311111962482573,0.18652391819209302,0.729265470167298,2045]
["Medium","Q9H8M1","Coenzyme Q-binding protein COQ10 homolog B, mitochondrial [OS=Homo sapiens]",3,1,1,1,238,27.1,9.6,2.33,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ10B","ENSG00000115520","","Respiratory electron transport","",103,109.4,104.8,97.4,96.3,95.5,1.0968188105117567,0.13332521875286077,0.009271330413718219,2.032857941165249,0.07717542416877596,1.1125209748856784,938]
["High","Q9H900-1","Protein zwilch homolog [OS=Homo sapiens]",25,11,21,11,591,67.2,6.27,32.56,"cell cycle OR cell proliferation;signal transduction;other biological processes","cytosol;other cell component","","ZWILCH","ENSG00000174442","","RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",780.3,748.7,757.6,789.5,839.8,784.8,0.9471852864421524,-0.0782814245431886,0.10027496098293719,0.9988074983305926,0.2835736672780781,0.5473341003112203,2761]
["High","Q9H920","RING finger protein 121 [OS=Homo sapiens]",5,1,1,1,327,37.9,7.06,3.13,"protein metabolism;other metabolic processes;stress response;signal transduction","other membranes;ER/Golgi","other molecular function","RNF121","ENSG00000137522","","","",18.5,14.9,19.3,15.6,19.6,23.4,0.8993174061433447,-0.15309770278503335,0.49572814495427475,0.3047564233354332,0.702859153042124,0.15313169515808037,5507]
["High","Q9H9B1","histone-lysine N-methyltransferase EHMT1 [OS=Homo sapiens]",28,24,47,23,1298,141.4,5.76,99.5,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","EHMT1","ENSG00000181090","Histone modifications; MTHFR deficiency","Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; Senescence-Associated Secretory Phenotype (SASP); Regulation of TP53 Activity through Methylation; Transcriptional Regulation by VENTX","Lysine degradation; Metabolic pathways; Longevity regulating pathway",1476.1,1603.3,1489.9,1577.5,1467.8,1601.3,0.9833641802608356,-0.024202289963969604,0.6776194083019929,0.16901416348350745,0.8276008665762491,0.08217906325873645,6393]
["High","Q9H9C1-1","Spermatogenesis-defective protein 39 homolog [OS=Homo sapiens]",31,13,18,13,493,57,7.4,40.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","C14orf133; VIPAS39","ENSG00000151445; ENSPTRG00000006581","","","",678.1,705.6,754.5,748.3,721.8,696.6,0.9868463562099045,-0.01910260837036875,0.7415078303233468,0.12988425846126953,0.8689318834105795,0.06101426707077055,6663]
["High","Q9H9J4-2","Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 42 [OS=Homo sapiens]",10,10,15,10,1316,144.2,8.47,24.71,"","","","USP42","","","","",570.9,533.4,538.2,544.3,498.7,527.3,1.045978475450551,0.06485316355401373,0.2471145054800172,0.607101761012197,0.47676551983888665,0.32169516074512833,4047]
["High","Q9H9Z2","Protein lin-28 homolog A [OS=Homo sapiens]",66,13,106,11,209,22.7,8.07,240.43,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","LIN28A","ENSG00000131914","Cardiac progenitor differentiation; CCL18 signaling pathway","Transcriptional regulation of pluripotent stem cells","",4434.3,4385.4,4340.7,4075.2,4508.2,4277.4,1.023295595919383,0.0332229516979043,0.4787737557564835,0.31986966370113573,0.6899714811640132,0.16116885973964976,5418]
["Medium","Q9HAB3","Solute carrier family 52, riboflavin transporter, member 2 [OS=Homo sapiens]",2,1,1,1,445,45.7,7.15,1.63,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC52A2","ENSG00000185803; ENSG00000285112","","Vitamin B2 (riboflavin) metabolism","",56.2,49.2,49.4,47.8,38.5,40.9,1.2169811320754718,0.28330680086005505,0.06361323176036383,1.1964525402819783,0.21501823098914322,0.6675247155154871,2310]
["High","Q9HAS0","Protein Njmu-R1 [OS=Homo sapiens]",26,6,7,6,396,44.6,5.03,15.59,"cell organization and biogenesis;transport","ER/Golgi;other cell component","","C17orf75","ENSG00000108666","","","",191.7,201.9,174,216.6,208.5,210.5,0.8930144745122719,-0.1632445352879677,0.056123182039352154,1.2508577135710686,0.20119825774254438,0.6963757843321893,2178]
["High","Q9HAV7","GrpE protein homolog 1, mitochondrial [OS=Homo sapiens]",41,10,16,10,217,24.3,8.12,27.2,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","GRPEL1","ENSG00000109519","","Mitochondrial protein import","",934.4,950.4,900.1,1081.8,757.8,729.9,1.0838295388207824,0.11613787215679292,0.562693257851095,0.24972828849912185,0.7529578332992888,0.12322934422187541,5835]
["High","Q9HB09-1","Bcl-2-like protein 12 [OS=Homo sapiens]",17,5,8,5,334,36.8,9.22,16.21,"other biological processes","nucleus","","BCL2L12","ENSG00000126453","Regulation of apoptosis by parathyroid hormone-related protein","","",368.5,408.5,374.2,297,290.4,283.3,1.3221545882623176,0.4028908687372735,0.002039990885235777,2.690371773015596,0.03747823254569634,1.4262208984072722,425]
["High","Q9HBE1-1","POZ-, AT hook-, and zinc finger-containing protein 1 [OS=Homo sapiens]",5,3,8,2,687,74,8.35,21.19,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PATZ1; ZNF278","ENSANAG00000029603; ENSCCAG00000028772; ENSCJAG00000010978; ENSG00000100105; ENSSBOG00000003894","Androgen receptor signaling pathway","","",122.8,118.9,114.6,135.7,139.9,127.1,0.8847777501862426,-0.1766129888124551,0.025444978731871345,1.5943979077946078,0.12934530855367934,0.8882493188314655,1536]
["High","Q9HBL8","NmrA-like family domain-containing protein 1 [OS=Homo sapiens]",10,3,7,3,299,33.3,7.52,12.91,"","cytosol;nucleus;other cell component","other molecular function","NMRAL1","ENSG00000153406; ENSG00000274684","","Urea cycle","",282.9,276.5,322,316.3,321.8,302.9,0.9366631243358129,-0.09439782633846316,0.26361013676715045,0.5790378935568075,0.4939447919073459,0.3063215893554501,4167]
["High","Q9HC07","Transmembrane protein 165 [OS=Homo sapiens]",22,4,12,4,324,34.9,7.02,39.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","TMEM165","ENSG00000134851","IL-18 signaling pathway","","",357.9,425.3,377,402.2,407.6,429.2,0.9364003228410008,-0.09480266304206009,0.2924741107418275,0.533912570811133,0.5252156984066673,0.2796623015667545,4348]
["Low","Q9HC96","Calpain-10 [OS=Homo sapiens]",1,1,1,1,672,74.9,7.74,1.79,"cell organization and biogenesis;protein metabolism;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","CAPN10","ENSG00000142330","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",47.8,56.7,39,54.7,54,55.1,0.8760683760683761,-0.19088462007795848,0.2567918589496297,0.5904187487858041,0.48536209989801715,0.31393413910375473,4131]
["High","Q9HCE3","Zinc finger protein 532 [OS=Homo sapiens]",16,15,26,14,1301,141.6,8.65,48.84,"","nucleus","nucleic acid binding activity;other molecular function","ZNF532","ENSG00000074657","","","",712.4,735.7,745.1,983,960.3,959,0.7556765324053336,-0.4041592744073388,4.5453228539369172E-5,4.342435263442352,0.007715191487725968,2.112653290465291,46]
["High","Q9HCJ3","Ribonucleoprotein PTB-binding 2 [OS=Homo sapiens]",3,2,3,2,691,74.3,7.47,2.09,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RAVER2","ENSG00000162437","","","",143.5,136.4,176,130.8,201,199.4,0.8582454819277108,-0.22053773748215982,0.39153234737618847,0.4072323518521415,0.621232385351205,0.2067459122275869,4921]
["High","Q9HCP0-1","Casein kinase I isoform gamma-1 [OS=Homo sapiens]",11,4,5,2,422,48.5,9.01,8.29,"cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK1G1","ENSG00000169118; ENSMFAG00000002355; ENSMMUG00000021124; ENSMNEG00000044820; ENSPPYG00000006548; ENSRROG00000038647","Wnt signaling pathway; Hedgehog signaling pathway","","Hedgehog signaling pathway",32.4,32.1,29.1,29.5,36.8,32.2,{"$f":"AVERAGE(T6594:V6594)/AVERAGE(W6594:Y6594)","v":0.9502538071065989},{"$f":"LOG(Z6594,2)","v":-0.07361519476033422},{"$f":"TTEST(T6594:V6594,W6594:Y6594,2,2)","v":0.5297948129098231},{"$f":"-LOG10(AB6594)","v":0.27589229808799287},{"$f":"AB6594*7808/AF6594","v":0.7290514450475677},{"$f":"-LOG10(AD6594)","v":0.13724182488919093},5674]
["High","Q9HD20","manganese-transporting ATPase 13A1 [OS=Homo sapiens]",16,17,38,17,1204,132.9,8.13,79.63,"transport;other biological processes","other membranes;ER/Golgi","transporter activity;other molecular function","ATP13A1","ENSG00000105726","","Ion transport by P-type ATPases","",1555.2,1417.5,1514.9,1321.7,1324.2,1410.3,1.1063557023815396,0.14581529837448,0.04569159694509843,1.3401636628608162,0.18036399845668785,0.7438501454633415,1978]
["High","Q9HD42-1","Charged multivesicular body protein 1a [OS=Homo sapiens]",16,5,10,5,196,21.7,8.06,18.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CHMP1A","ENSG00000131165; ENSPPAG00000031215; ENSPPYG00000007667","","HCMV Late Events","Endocytosis; Necroptosis",614.6,521.1,505.7,603.8,538.7,552.3,0.9684918574463064,-0.046188175404435726,0.6746897677394219,0.1708958762505205,0.8258312755148779,0.08310867374234557,6379]
["High","Q9NNW7-1","thioredoxin reductase 2, mitochondrial [OS=Homo sapiens]",19,6,8,5,524,56.5,7.5,22.01,"stress response;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","TXNRD2","ENSG00000184470","Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Oxidative stress response; 22q11.2 copy number variation syndrome","Detoxification of Reactive Oxygen Species","Selenocompound metabolism; Pathways in cancer; Hepatocellular carcinoma",256.5,255.1,261.7,239.6,239.7,254.4,1.0539730134932535,0.0758379278879504,0.06781332158055695,1.168684982819898,0.22350629586365076,0.6507102388840276,2369]
["High","Q9NP73-1","Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 [OS=Homo sapiens]",8,6,6,6,1137,126,6.74,8.65,"protein metabolism","other membranes;ER/Golgi","other molecular function","ALG13","ENSG00000101901","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG14 causes ALG14-CMS","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways",87.5,73.5,113.1,87,131.7,104.5,0.8480816831683169,-0.2377248699260195,0.4007098557765726,0.3971699756188572,0.6270025158123205,0.20273071658361166,4990]
["Medium","Q9NP87","DNA-directed DNA/RNA polymerase mu [OS=Homo sapiens]",2,1,1,1,494,54.8,8.41,2.27,"DNA metabolism;other metabolic processes;stress response","nucleus","nucleic acid binding activity;other molecular function","POLM","ENSG00000122678","Non-homologous end joining; DNA repair pathways, full network","Nonhomologous End-Joining (NHEJ)","Non-homologous end-joining",25.4,21,31.9,20.1,34.3,24,0.9987244897959182,-1.8413468241677727E-3,0.9952724806423543,2.058004039106547E-3,0.9969323321174474,1.334318905331641E-3,7795]
["Medium","Q9NPE2-2","Neugrin [OS=Homo sapiens]",3,1,1,1,291,32.4,9.1,2.4,"developmental processes;other biological processes","non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus","nucleic acid binding activity","NGRN","ENSG00000182768","","","",29.6,31.9,37.8,35,29.9,27.4,1.075839653304442,0.10546306988259974,0.519883355931051,0.28409408628446026,0.7213878164403138,0.1418311967798175,5627]
["High","Q9NPH2","Inositol-3-phosphate synthase 1 [OS=Homo sapiens]",24,12,52,12,558,61,5.76,130.48,"other metabolic processes","cytosol;other cell component","other molecular function","ISYNA1","ENSG00000105655","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways",1742.7,1820.6,1682.1,1564.4,1532.6,1571.4,1.1235969497043954,0.16812461301205456,0.01004245870448218,1.9981599454516448,0.08125545861616255,1.090147454136802,965]
["High","Q9NPJ8","NTF2-related export protein 2 [OS=Homo sapiens]",21,3,6,1,142,16.2,5.48,4.31,"transport","cytosol;nucleus;other cell component","","NXT2","ENSG00000101888","","","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; mRNA surveillance pathway; Amyotrophic lateral sclerosis; Influenza A",116,129,132,112.9,116.2,101.7,1.1396614268440146,0.1886052889847521,0.07950362970636349,1.0996130433503226,0.24731647041724547,0.6067469601727252,2510]
["High","Q9NQ66-1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [OS=Homo sapiens]",4,3,3,3,1216,138.5,6.23,2.5,"cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PLCB1","ENSG00000182621; ENSPPAG00000023075; ENSPTRG00000013241","AMP-activated protein kinase (AMPK) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; S1P receptor signal transduction; Cell-type dependent selectivity of CCK2R signaling; Chemokine signaling pathway; GPR40 pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; Fragile X syndrome; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; Alzheimer's disease","Ca2+ pathway; Synthesis of IP3 and IP4 in the cytosol; G alpha (q) signalling events; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Inositol phosphate metabolism; Metabolic pathways; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Apelin signaling pathway; Gap junction; Platelet activation; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Pathways in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis",11,12.1,14.1,13.1,12.1,12.8,0.9789473684210527,-0.030696797222916385,0.7938095162734153,0.10028369902893117,0.8946398243450963,0.048351773379585995,6928]
["High","Q9NQC3","Reticulon-4 [OS=Homo sapiens]",46,30,150,22,1192,129.9,4.5,322.61,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","RTN4","ENSG00000115310","Alzheimer's disease and miRNA effects; Spinal cord injury; 22q11.2 copy number variation syndrome; Alzheimer's disease","Axonal growth inhibition (RHOA activation)","Alzheimer disease",3190.5,3122,3046.4,3013.1,2776.6,2854.9,1.0826296184901556,0.11453976283483311,0.04249664613547937,1.3716453434162625,0.17399780441836546,0.7594562318036328,1907]
["High","Q9NQG6","Mitochondrial dynamics protein MID51 [OS=Homo sapiens]",8,4,5,4,463,51.3,7.64,8.82,"cell organization and biogenesis;stress response;other biological processes","other membranes;mitochondrion","other molecular function","MIEF1","ENSG00000100335","","","",250.1,213.9,225.9,242.6,213.9,227.6,1.0084782926472737,0.012180030478217453,0.8929837006739242,0.04915646806775333,0.9463106317673725,0.023966280597910405,7368]
["High","Q9NQT5","exosome complex component RRP40 [OS=Homo sapiens]",36,5,15,5,275,29.6,8.1,39.12,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","EXOSC3","ENSG00000107371","","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","RNA degradation",438.9,429.2,458.2,473.8,501,448.6,0.9317830546578614,-0.10193400095458247,0.1357976137475664,0.8671078614647189,0.3370336198795291,0.47232677509335147,3146]
["High","Q9NQY0-1","Bridging integrator 3 [OS=Homo sapiens]",16,3,3,3,253,29.6,7.47,8.77,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","other molecular function","BIN3","ENSG00000147439; ENSGGOG00000002428; ENSPPAG00000028325; ENSPTRG00000020066","","","",205,246.1,167.3,187.7,189.7,196.4,1.0777274311606833,0.10799235115618312,0.5517054758318394,0.2582927055261284,0.7470892048725288,0.12662753891968204,5766]
["High","Q9NR19-1","Acetyl-coenzyme A synthetase, cytoplasmic [OS=Homo sapiens]",5,4,9,3,701,78.5,6.46,19.43,"other metabolic processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","ACSS2","ENSG00000131069","Fatty acid beta-oxidation; Fatty acid biosynthesis; Lipid metabolism pathway; Ethanol effects on histone modifications; Fluoroacetic acid toxicity; Amino acid conjugation of benzoic acid","Transcriptional activation of mitochondrial biogenesis; Ethanol oxidation","Glycolysis / Gluconeogenesis; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism",357.2,355.8,384,395.1,384.7,408.8,0.9229345448426721,-0.11569976032008727,0.057063549218598464,1.2436412197431648,0.20289261944390566,0.6927337508625837,2196]
["High","Q9NR45","sialic acid synthase [OS=Homo sapiens]",49,13,69,13,359,40.3,6.74,117.51,"other metabolic processes","cytosol;other cell component","other molecular function","NANS","ENSG00000095380","","Sialic acid metabolism","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",1927.7,1946,1995.4,1803.6,1802.8,1853.1,1.0750251854565438,0.10437045935671836,0.00645101107664433,2.1903722124042946,0.0640833263186246,1.1932549537850672,786]
["High","Q9NRF8","CTP synthase 2 [OS=Homo sapiens]",37,19,50,15,586,65.6,6.9,98.28,"other metabolic processes","cytosol;other cell component","other molecular function","CTPS2","ENSG00000047230","Pyrimidine metabolism","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",1891.4,1818.1,1973.2,1878,2064.6,2035,0.9506658190578158,-0.07298980523840591,0.25047779489415195,0.6012307687284026,0.48028748097581986,0.31849873339846957,4072]
["High","Q9NRG9-1","Aladin [OS=Homo sapiens]",37,14,30,14,546,59.5,7.5,74.13,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus","","AAAS","ENSG00000094914","","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; RHOA GTPase cycle; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; Regulation of HSF1-mediated heat shock response; Vpr-mediated nuclear import of PICs; Viral Messenger RNA Synthesis; tRNA processing in the nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Ribonucleoproteins into the Host Nucleus; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)","Nucleocytoplasmic transport",1149,1119.3,1220.4,1093.8,1229.3,1172.7,0.997968991361062,-0.002933105682167545,0.9641120246312116,0.01587250048251025,0.9805635910278103,0.008524236430722773,7677]
["High","Q9NRN9","Methyltransferase-like protein 5 [OS=Homo sapiens]",16,2,7,2,209,23.7,6.68,4.94,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","METTL5","ENSG00000138382","","","",30.8,33.3,35.5,30.6,50.4,42.7,0.8051738075990298,-0.312627852908289,0.24633738932878232,0.6084696655185836,0.4760896870987951,0.32231122597055323,4040]
["High","Q9NRV9","Heme-binding protein 1 [OS=Homo sapiens]",66,11,41,11,189,21.1,5.8,79.41,"other biological processes","non-structural extracellular;other cell component","other molecular function","HEBP1","ENSG00000013583","","G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands","",1954.1,1955.4,1933.4,1773.3,1827.1,1773.1,1.0873546105890015,0.12082251212959165,1.2656694007481296E-3,2.8976797194219435,0.030882333378254363,1.5102898930832138,320]
["High","Q9NRX2","39S ribosomal protein L17, mitochondrial [OS=Homo sapiens]",9,2,3,2,175,20,10.11,7.03,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL17","ENSG00000158042","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",291.4,258,242.4,301.9,240,240.9,1.0114971895758815,0.016492311403292964,0.9105190283136767,0.040710973751237556,0.9544009361086304,0.020269143366828883,7449]
["High","Q9NS69","Mitochondrial import receptor subunit TOM22 homolog [OS=Homo sapiens]",51,4,34,4,142,15.5,4.34,103.23,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity","TOMM22","ENSG00000100216","","PINK1-PRKN Mediated Mitophagy; Mitochondrial protein import","",1017.3,1112.5,1068.7,991.5,1037.9,1031,1.0451248202849301,0.06367525508340223,0.2126582752917666,0.6723177126742773,0.4371868913844427,0.3593328684166407,3798]
["High","Q9NS91","E3 ubiquitin-protein ligase RAD18 [OS=Homo sapiens]",16,6,13,6,495,56.2,7.58,36.28,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD18","ENSG00000070950","SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Recognition of DNA damage by PCNA-containing replication complex; E3 ubiquitin ligases ubiquitinate target proteins","",733.5,822.8,784.7,777.2,848.4,820.3,0.9571119015495321,-0.06324048640095833,0.35083536349752126,0.4548966370911399,0.5832068380218535,0.2341773926157535,4697]
["High","Q9NSG2-1","Uncharacterized protein C1orf112 [OS=Homo sapiens]",3,2,4,2,853,96.5,6,2.5,"","","","C1orf112","ENSG00000000460","","","",78.3,84.3,72.2,83.5,83.5,99.5,0.8810506566604128,-0.1827031245364859,0.1727757378311133,0.7625172437197408,0.38499799114878214,0.4145415365571486,3504]
["High","Q9NSV4-3","Protein diaphanous homolog 3 [OS=Homo sapiens]",9,8,12,8,1193,136.8,7.03,20.5,"cell organization and biogenesis","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","DIAPH3","ENSG00000139734","Regulation of actin cytoskeleton","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; RHOC GTPase cycle; RHO GTPases Activate Formins; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","Regulation of actin cytoskeleton",308.8,316.4,338.7,282.5,299.9,297,1.0960882419831703,0.13236394897992104,0.054541041981865844,1.263276569316063,0.19788868763680695,0.7035790316517793,2152]
["High","Q9NTK5-1","obg-like ATPase 1 [OS=Homo sapiens]",71,23,115,10,396,44.7,7.81,241.2,"other metabolic processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","translation activity;other molecular function","LOC111144733; Ola1; OLA1","ENSCCAG00000017844; ENSFCAG00000036661; ENSG00000138430; ENSLCNG00005010543; ENSMMUG00000007092; ENSMNEG00000040767; ENSMPUG00000013906; ENSNVIG00000008347; ENSPTRG00000012650; ENSRROG00000038551","","Platelet degranulation","",6197.5,5719.2,6176.9,6522.4,6300.6,6383.2,0.9420707896408451,-0.0860926231314469,0.09322092441585265,1.030486594744849,0.27169428064164897,0.5659195036944223,2679]
["High","Q9NTX7","E3 ubiquitin-protein ligase rnf146 [OS=Homo sapiens]",11,3,3,3,359,38.9,5.33,7.74,"cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RNF146","ENSG00000118518","","Ub-specific processing proteases; Degradation of AXIN; Regulation of PTEN stability and activity","",175.8,188.4,198.5,151.9,167.6,155,1.1858798735511067,0.24595787614908568,0.022467598337282787,1.648443348791842,0.12157103798856826,0.9151698752267008,1443]
["High","Q9NUI1","Peroxisomal 2,4-dienoyl-CoA reductase [OS=Homo sapiens]",12,3,4,3,292,30.8,9.22,10.7,"other metabolic processes","other membranes;cytosol;other cytoplasmic organelle","other molecular function","DECR2","ENSG00000242612; ENSG00000274296","","Peroxisomal protein import; Beta-oxidation of very long chain fatty acids","Peroxisome",207.1,180.3,212.4,161.7,178.7,183.2,1.1455309396485867,0.1960164249234994,0.09967259098423421,1.0014242521280412,0.2827920023273622,0.5485328770328796,2752]
["High","Q9NUQ3-1","Gamma-taxilin [OS=Homo sapiens]",35,16,29,16,528,60.5,7.52,53.28,"cell cycle OR cell proliferation;other biological processes","other membranes;cytosol;nucleus","other molecular function","TXLNG","ENSG00000086712","","","",898.6,836.4,856.5,954.4,869.7,834.6,0.9747244894121189,-0.036933603130818005,0.6053767263635927,0.21797427945832917,0.7814153545126356,0.1071180593070445,6049]
["High","Q9NUQ6","SPATS2-like protein [OS=Homo sapiens]",4,3,4,3,558,61.7,9.64,2.15,"","cytosol;nucleus;other cell component","","SPATS2L","ENSG00000196141","","","",213.7,222.4,231.3,300.5,317.1,308.9,0.7203453858607665,-0.47323928973230844,2.457707399459999E-4,3.6094698229809,0.015110062499987144,1.8207337392782215,127]
["High","Q9NUY8","TBC1 domain family member 23 [OS=Homo sapiens]",14,7,14,7,699,78.3,5.41,30.47,"cell organization and biogenesis;transport;developmental processes","cytosol;ER/Golgi;other cell component","","TBC1D23","ENSG00000036054","","","",211,241.6,245.5,267,301,279.7,0.8235224725728443,-0.2801200756254279,0.027728320784865704,1.5570764303120974,0.13607965348097512,0.8662068053000435,1591]
["High","Q9NVA2-1","Septin-11 [OS=Homo sapiens]",40,17,85,7,429,49.4,6.81,191.24,"cell cycle OR cell proliferation;other biological processes","cytoskeleton;other cell component","other molecular function","Sept11; SEPT11; SEPTIN11","ENSANAG00000029750; ENSBTAG00000021372; ENSCATG00000027299; ENSCCAG00000022420; ENSCHIG00000021075; ENSCSAG00000004591; ENSFCAG00000027412; ENSG00000138758; ENSLCNG00005000771; ENSMFAG00000042066; ENSMMUG00000019901; ENSMNEG00000044831; ENSNLEG00000032040; ENSPCTG00005005661; ENSPPAG00000041700; ENSPTRG00000016192; ENSRBIG00000024343; ENSRROG00000038768; ENSSBOG00000020488; ENSSSUG00005020042; ENSUAMG00000017287","22q11.2 copy number variation syndrome","","Bacterial invasion of epithelial cells; Shigellosis",5110.1,5309.1,5147.4,5311.2,5342.6,5431.1,0.9677772320623691,-0.04725309613254932,0.07130242245310403,1.1468957150268995,0.23062523384997358,0.6370931761295945,2414]
["High","Q9NVF7-1","F-box only protein 28 [OS=Homo sapiens]",24,8,10,8,368,41.1,9.55,27.6,"protein metabolism;other metabolic processes","other cell component","other molecular function","FBXO28","ENSG00000143756; ENSGGOG00000010974; ENSPPAG00000034613; ENSPTRG00000002021","","","",391.7,405.4,403.2,396.3,359.6,395.8,1.042198489189893,0.059630068498652114,0.27664048698280047,0.5580842595611992,0.5077595022006831,0.29434194046927403,4254]
["High","Q9NVI1-3","Fanconi anemia group I protein [OS=Homo sapiens]",30,35,82,35,1328,149.2,6.74,164.89,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","FANCI","ENSG00000140525","Gastric cancer network 2; DNA repair pathways, full network","TP53 Regulates Transcription of DNA Repair Genes; Fanconi Anemia Pathway","Fanconi anemia pathway",3416.8,3637.6,3636.8,3704.2,3794.7,3855.3,0.9416075108770323,-0.0868022665863769,0.06118389770509777,1.2133628598473072,0.21054379606937126,0.6766575510736078,2269]
["High","Q9NVM4","Protein arginine N-methyltransferase 7 [OS=Homo sapiens]",15,7,9,7,692,78.4,5.57,20.75,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","PRMT7","ENSG00000132600","Nitric oxide metabolism in cystic fibrosis","RMTs methylate histone arginines","",228.3,209.5,237.4,224.8,213.2,218.3,1.0287978058814569,0.040959470944014274,0.5169403769016052,0.2865595448670928,0.7192213939500595,0.14313740256477966,5612]
["High","Q9NVN3-1","Isoform 1 of Synembryn-B [OS=Homo sapiens]",12,4,7,4,536,60.8,5.88,11.38,"","","","RIC8B","","","","",245.9,199.4,245.1,201.6,168.2,171.9,1.2745061842348164,0.3499383737079025,0.056547945935298875,1.247583165896207,0.20207156149327857,0.6944948025440122,2185]
["High","Q9NVS2","39S ribosomal protein S18a, mitochondrial [OS=Homo sapiens]",17,3,3,3,196,22.2,10.33,4.29,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS18A","ENSG00000096080","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",249.6,185.6,189.9,243.4,199.6,189.6,0.9881441669301296,-0.017206553338566657,0.9292392815371596,0.031872439644249094,0.9645706341720477,0.015665964071993985,7522]
["High","Q9NVX7-1","Kelch repeat and BTB domain-containing protein 4 [OS=Homo sapiens]",3,1,1,1,518,58.1,5.67,3.94,"","","","KBTBD4","ENSG00000123444; ENSG00000284900","","","",17.2,18.9,15.4,24.8,21.8,18.2,0.7947530864197531,-0.33142138081404404,0.1092606291126882,0.9615363031864154,0.29766468671035223,0.5262726845891056,2866]
["High","Q9NVZ3","Adaptin ear-binding coat-associated protein 2 [OS=Homo sapiens]",28,6,14,6,263,28.3,8.38,33.44,"transport","plasma membrane;other membranes","","NECAP2","ENSG00000157191","","Cargo recognition for clathrin-mediated endocytosis","",763.1,721.9,819.9,630.4,689.2,610,1.1944962686567167,0.2564023471396963,0.027813897719945704,1.5557381467111389,0.13632825699769996,0.865414117853635,1593]
["High","Q9NW82","WD repeat-containing protein 70 [OS=Homo sapiens]",19,11,15,11,654,73.2,6.33,24.47,"other biological processes","nucleus;other cell component","other molecular function","WDR70","ENSG00000082068","","","",653.7,683.4,626.2,653.7,622.2,608.8,1.0417042500132645,0.05894574057001091,0.2843368599439822,0.5461668369939454,0.5155834190530918,0.2877010578227783,4306]
["High","Q9NWM8","Peptidyl-prolyl cis-trans isomerase FKBP14 [OS=Homo sapiens]",7,1,2,1,211,24.2,6.07,2.62,"protein metabolism;other metabolic processes","ER/Golgi","other molecular function","FKBP14","ENSG00000106080","","XBP1(S) activates chaperone genes","",37.4,35.9,31.5,33.6,32.9,28.1,1.1078224101479914,0.14772662819805496,0.24137303625386322,0.6173112465013332,0.47198614251694565,0.32607075203703534,3993]
["High","Q9NWQ9","Uncharacterized protein C14orf119 [OS=Homo sapiens]",14,2,2,2,140,16,4.94,1.73,"","cytosol;mitochondrion","","C14orf119","ENSG00000179933","","","",114.3,121.2,88.2,91.1,90.4,85.2,1.2137232845894264,0.279439540658247,0.1365496267053952,0.8647094827817257,0.33793327585284494,0.4711690417032433,3155]
["High","Q9NWX5","Ankyrin repeat and SOCS box protein 6 [OS=Homo sapiens]",7,2,2,2,421,47.1,6.01,7.64,"protein metabolism;other metabolic processes;signal transduction","cytosol","","ASB6","ENSG00000148331","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",102,105.8,102.4,87.3,91.2,80.4,1.1981460023174975,0.26080372113598005,0.007183519220828441,2.1436627418652994,0.06709200726821588,1.1733292146456806,836]
["High","Q9NWZ5-1","Uridine-cytidine kinase-like 1 [OS=Homo sapiens]",11,6,9,6,548,61.1,7.36,8.55,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","UCKL1","ENSG00000198276; ENSPPAG00000038781","Pyrimidine metabolism","Pyrimidine salvage","Pyrimidine metabolism; Drug metabolism; Metabolic pathways",312.1,285.8,300.2,292.2,312.6,299.1,0.9935833609912603,-0.0092870811683324,0.851440150407707,0.06984587413847365,0.9279794380769649,0.032461646656832155,7164]
["High","Q9NX24","H/ACA ribonucleoprotein complex subunit 2 [OS=Homo sapiens]",18,2,4,2,153,17.2,8.22,11.53,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","NHP2","ENSG00000145912","","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","Ribosome biogenesis in eukaryotes",71.4,82.4,72.5,100.2,77.5,79.5,0.8798600311041991,-0.18465405806105487,0.2701674421258788,0.5683669889817415,0.5010611373203946,0.30010928015877447,4210]
["High","Q9NX61","Transmembrane protein 161A [OS=Homo sapiens]",3,1,2,1,479,53.6,8.44,7.7,"stress response;other biological processes","other membranes","","TMEM161A","ENSG00000064545","","","",52.2,54.2,53,41.4,53.7,56.6,1.0507580751483192,0.07143054374343852,0.6136830305361272,0.21205588559078442,0.7862876768011291,0.10441853081880384,6094]
["Medium","Q9NX76","CKLF-like MARVEL transmembrane domain-containing protein 6 [OS=Homo sapiens]",5,1,4,1,183,20.4,5.29,5.8,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","","CMTM6","ENSG00000091317","","Neutrophil degranulation","",68.1,68.6,63.6,47.5,50.5,49.8,1.355209742895805,0.43851615166655655,6.6801347279712314E-4,3.175214778389063,0.023389458276232903,1.6309798367785882,223]
["High","Q9NXF1","Testis-expressed protein 10 [OS=Homo sapiens]",15,13,34,13,929,105.6,9.36,68.49,"","mitochondrion;nucleus","","TEX10","ENSG00000136891","","Major pathway of rRNA processing in the nucleolus and cytosol","",1070.9,1187.1,1077.4,1151.1,1066.3,1164.5,0.9862503326532422,-0.019974213153304707,0.7659435905593817,0.11580321367141566,0.8805193691236237,0.0552610862486765,6792]
["High","Q9NXN4-1","Ganglioside-induced differentiation-associated protein 2 [OS=Homo sapiens]",9,3,3,3,497,56.2,5.74,4.92,"other biological processes","","","GDAP2","ENSG00000196505","","","",31.9,34.8,32.7,31.1,29,30.5,1.0971302428256071,0.13373480151605116,0.05137443084436799,1.289252976454454,0.19137955917596627,0.7181044501075076,2096]
["High","Q9NXS2","Glutaminyl-peptide cyclotransferase-like protein [OS=Homo sapiens]",2,2,3,2,382,42.9,9.82,6.22,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","QPCTL","ENSG00000011478","","","",191.5,227.4,196.1,178.5,169.9,204.1,1.1131221719457014,0.15461194594780836,0.24378273875509726,0.6129970482205185,0.47420419138011943,0.3240346117133498,4014]
["High","Q9NY27","Serine/threonine-protein phosphatase 4 regulatory subunit 2 [OS=Homo sapiens]",60,17,47,17,417,46.9,4.54,107.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP4R2","ENSG00000163605","16p11.2 proximal deletion syndrome","Processing of DNA double-strand break ends","",1526.6,1627.5,1541.4,1770.6,1549,1720.9,0.9315544092847932,-0.10228805979135953,0.19581196504533063,0.7081607742570966,0.4141115447112518,0.38288266195233556,3692]
["High","Q9NYF3","protein FAM53C [OS=Homo sapiens]",3,1,2,1,392,43.1,8.65,4.74,"transport","nucleus","","FAM53C","ENSG00000120709","","","",30.5,31.7,34.8,30.8,23.1,21.3,1.2898936170212767,0.3672520853968528,0.08448279369088067,1.0732317332516355,0.25537810806751693,0.5928163347663172,2583]
["Medium","Q9NYG2-1","Palmitoyltransferase ZDHHC3 [OS=Homo sapiens]",3,1,2,1,299,34.1,8.18,0,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","ZDHHC3","ENSCCAG00000029642; ENSG00000163812","","","",40.5,50,42.9,38.3,35.5,46.2,1.1116666666666668,0.1527242606887043,0.3565092160347057,0.4479292388239423,0.590000839084142,0.22914737071488359,4718]
["High","Q9NYP3-1","Protein downstream neighbor of son [OS=Homo sapiens]",11,4,5,4,566,62.7,8.66,3.66,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction","nucleus;other cell component","","DONSON","ENSG00000159147","","","",152.5,142.8,127.2,171.4,175.1,189.3,0.7885405001866369,-0.34274323978546983,0.014625096962486744,1.8349012459204246,0.09895386229037824,1.004567250081502,1154]
["High","Q9NYU1","UDP-glucose:glycoprotein glucosyltransferase 2 [OS=Homo sapiens]",5,7,9,6,1516,174.6,6.89,9.87,"protein metabolism;other metabolic processes;stress response","ER/Golgi;other cell component","other molecular function","UGGT2","ENSG00000102595","","ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",143,158.4,137.4,143.7,138.2,155.5,1.0032007315957934,0.004610305355099683,0.9567709678945463,0.019192011318132543,0.9778099106440599,0.009745565235187078,7640]
["High","Q9NYZ3","G2 and S phase-expressed protein 1 [OS=Homo sapiens]",9,5,8,5,720,76.6,9.39,10.13,"cell cycle OR cell proliferation;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","GTSE1","ENSG00000075218","","The role of GTSE1 in G2/M progression after G2 checkpoint; G2/M Checkpoints","p53 signaling pathway",232.7,247.8,193.9,161,120,127.3,1.6517266715650256,0.7239749687169313,0.012225106068801703,1.9127473641147352,0.090306176144942,1.0442825467635262,1057]
["High","Q9NZ53-1","Podocalyxin-like protein 2 [OS=Homo sapiens]",2,1,2,1,605,65,4.34,2.38,"cell adhesion","plasma membrane;other membranes;ER/Golgi","other molecular function","PODXL2","ENSG00000114631","","Cytosolic sulfonation of small molecules","",20.1,24,13.1,19.8,21.4,21.1,0.9181380417335472,-0.12321701624561272,0.626116597646529,0.20334478340421785,0.7946551356346064,0.09982130553895707,6152]
["High","Q9NZ72","Stathmin-3 [OS=Homo sapiens]",13,3,3,2,180,21,7.49,5.11,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","STMN3","ENSG00000197457","","","",115.6,87.1,100.1,99.4,113.9,93.2,0.9879282218597062,-0.01752186859241246,0.9102053781103382,0.04086060271586788,0.9543283996623501,0.02030215190060182,7447]
["High","Q9NZI7","Upstream-binding protein 1 [OS=Homo sapiens]",16,6,15,5,540,60.5,6.35,38.79,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBP1","ENSG00000153560","","","",489.3,450.6,468,396.2,476.4,406.4,1.1007818608287725,0.13852860198042002,0.19423619188517532,0.7116698451202143,0.4122305480400786,0.3848598282927058,3679]
["High","Q9NZJ5","Eukaryotic translation initiation factor 2-alpha kinase 3 [OS=Homo sapiens]",14,10,17,10,1116,125.1,5.43,43.91,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","EIF2AK3","ENSG00000172071","Translation factors; Alzheimer's disease and miRNA effects; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; 7q11.23 copy number variation syndrome; Alzheimer's disease","Signaling by ALK fusions and activated point mutants; ALK mutants bind TKIs; PERK regulates gene expression","Mitophagy; Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Hepatitis C; Measles; Herpes simplex virus 1 infection; Lipid and atherosclerosis",648.7,694.9,684,552,588.1,584.2,1.17589746563823,0.23376226743245818,4.973414270841958E-3,2.303345363802714,0.055793704923468405,1.2534147987546407,696]
["High","Q9NZM5","ribosome biogenesis protein NOP53 [OS=Homo sapiens]",15,5,9,5,478,54.4,10.32,18.47,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP53","ENSG00000105373","","","",312.2,328.4,264,482.2,288,403.3,0.7708564124414145,-0.3754659407791217,0.20711805883652404,0.6837820328731875,0.42964341216673213,0.3668918429697714,3764]
["High","Q9NZV5-1","Selenoprotein N [OS=Homo sapiens]",5,3,7,3,590,65.8,5.48,12.9,"cell organization and biogenesis;stress response;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SELENON","ENSG00000162430","Selenium micronutrient network","","",481.6,458.5,538.3,455.3,475,464.1,1.0602409638554218,0.08439218729037261,0.3148182016046151,0.5019401663132044,0.5479492907108414,0.26125963090151794,4486]
["High","Q9P000-1","COMM domain-containing protein 9 [OS=Homo sapiens]",34,4,5,4,198,21.8,5.88,11.85,"transport;other biological processes","non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component","","COMMD9","ENSG00000110442","","Neddylation; Neutrophil degranulation","",301.3,273.8,319.4,318.6,346.4,345.2,0.8854682241140368,-0.17548755949193207,0.07429330656416785,1.129050312123572,0.23657509692211365,0.6260309733113139,2452]
["High","Q9P0J0","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [OS=Homo sapiens]",43,5,31,5,144,16.7,8.43,47.91,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;mitochondrion;nucleus;other cell component","transporter activity;other molecular function","NDUFA13","ENSG00000186010","Nucleotide-binding oligomerization domain (NOD) pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",845.9,893.4,859,770.7,876.5,817.1,1.054376496368137,0.07639011598300936,0.2560936069650215,0.591601262978149,0.4849815384872393,0.3142747931208721,4123]
["High","Q9P0N9","TBC1 domain family member 7 [OS=Homo sapiens]",29,6,8,6,293,34,7.94,12.97,"other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","TBC1D7","ENSG00000145979","Fragile X syndrome","TBC/RABGAPs","mTOR signaling pathway",218,215.8,232.7,212.3,220.6,209.6,1.037354085603113,0.05290842100773282,0.26991039204839884,0.5687803939822358,0.5008223244091964,0.30031632046928297,4208]
["High","Q9P0S3","ORM1-like protein 1 [OS=Homo sapiens]",20,2,5,2,153,17.4,9.64,11.03,"other metabolic processes;other biological processes","other membranes;ER/Golgi","","ORMDL1","ENSG00000128699","","Sphingolipid de novo biosynthesis","",191.4,194.2,228.7,156.3,167.4,160.5,1.268690623709211,0.3433403039649845,0.02510211218924682,1.6002897337563944,0.128691590265029,0.8904498324338016,1523]
["High","Q9P1F3","Costars family protein ABRACL [OS=Homo sapiens]",16,1,3,1,81,9.1,6.29,3.27,"other biological processes","","","ABRACL","ENSG00000146386","","","",20.1,28.1,16.8,33.6,23.4,25.3,0.7897934386391252,-0.3404527125058087,0.27730003131987024,0.5570500813704036,0.508253202944964,0.29391987581448714,4260]
["High","Q9P1U1-1","Actin-related protein 3B [OS=Homo sapiens]",25,8,34,4,418,47.6,5.88,59.14,"","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTR3B","ENSCANG00000039781; ENSCATG00000043872; ENSCCAG00000019061; ENSCJAG00000019650; ENSCSAG00000006554; ENSG00000133627; ENSMFAG00000034566; ENSMMUG00000018920; ENSMNEG00000033219; ENSPANG00000006816; ENSPPYG00000018206; ENSPTRG00000019897; ENSRROG00000045018","","","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",362,352.4,368.3,366.9,355.7,356.8,1.0030572540300169,0.00440395664575075,0.859701974357997,0.0656520758768441,0.9317813736517547,0.030685975365704384,7204]
["High","Q9P219","Protein Daple [OS=Homo sapiens]",7,12,13,12,2028,228.1,6.23,29.23,"cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","CCDC88C","ENSG00000015133","Ectoderm differentiation; Ectoderm differentiation","Negative regulation of TCF-dependent signaling by DVL-interacting proteins","",735.7,750.6,685.9,760.2,734.4,758.8,0.9639655631490195,-0.0529464865665074,0.27231595603414854,0.5649269109385393,0.5028956917489669,0.29852208491529253,4228]
["High","Q9P275","Ubiquitin carboxyl-terminal hydrolase 36 [OS=Homo sapiens]",15,14,22,14,1121,122.6,9.67,34.03,"","","","","","","","",984.5,955.8,991.8,1006.6,962.2,923.9,1.0136204929650499,0.01951759770519293,0.6437397757391665,0.19128965562115785,0.8056291343118148,0.09386483659288569,6239]
["High","Q9P2D3-1","HEAT repeat-containing protein 5B [OS=Homo sapiens]",7,9,13,9,2071,224.2,7.17,17.02,"transport;other biological processes","cytosol;other cell component","","HEATR5B","ENSG00000008869","","","",319,303,334.8,314,337.3,323.9,0.9811320754716981,-0.02748073642210701,0.6189677920736698,0.2083319488612994,0.7895606143622306,0.10261452370185148,6121]
["High","Q9P2E5-1","Chondroitin sulfate glucuronyltransferase [OS=Homo sapiens]",8,6,8,6,772,85.9,7.83,9.18,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHPF2","ENSG00000033100; ENSGGOG00000001088","","Chondroitin sulfate biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",517.4,540.9,555.7,513.3,499.6,500.1,1.0667547918043623,0.09322859106104328,0.048759734386112384,1.3119386688239572,0.18671702113132196,0.7288160899434618,2039]
["High","Q9P2J5","Leucine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",48,52,268,52,1176,134.4,7.3,493.34,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","LARS1","ENSG00000133706","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",9361.1,9455.3,9534.1,9479,10019.8,9960.1,0.9623746983084908,-0.055329381617663854,0.10702522011163611,0.9705138703082228,0.29372686067896475,0.5320563363806774,2845]
["High","Q9P2L0-1","WD repeat-containing protein 35 [OS=Homo sapiens]",7,5,9,5,1181,133.5,6.38,22.32,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","","WDR35","ENSG00000118965","Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",206,192.7,206.5,219,213.9,243.4,0.8948691409137958,-0.16025136620618047,0.08007977756226459,1.0964771418675892,0.24802177834437206,0.6055101828853997,2521]
["High","Q9P2R3","Rabankyrin-5 [OS=Homo sapiens]",16,15,25,14,1169,128.3,6.1,57.1,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ANKFY1","ENSG00000185722","","RHOD GTPase cycle","",961.7,924.8,1051.3,849.8,905.7,827.2,1.1374917721764046,0.18585610989750642,0.055398007436904394,1.2565058557538764,0.19960666454423143,0.6998249624150589,2167]
["Medium","Q9P2Z0","THAP domain-containing protein 10 [OS=Homo sapiens]",4,1,2,1,257,28.3,8.6,5.18,"","","nucleic acid binding activity;other molecular function","THAP10","ENSG00000129028","","","",141.3,116.1,139.8,128.1,125.5,111.5,1.0879211175020542,0.12157395409348931,0.3298264385969052,0.4817145346328769,0.5616760812572814,0.2505140699802815,4585]
["High","Q9UBB6","Neurochondrin [OS=Homo sapiens]",37,21,61,21,729,78.8,5.48,142.15,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","NCDN","ENSG00000020129","Splicing factor NOVA regulated synaptic proteins","","",1754.7,1755.7,1870.3,1543,1578.3,1610.8,1.1370638828427124,0.1853133104054941,0.007389183347588817,2.1314035571713474,0.06827780305085619,1.1657204614624042,845]
["High","Q9UBF8-2","Isoform 2 of Phosphatidylinositol 4-kinase beta [OS=Homo sapiens]",5,3,3,3,801,89.8,6.44,4.63,"","","","PI4KB","","","","",75.9,75.1,78.3,70.1,59.8,81.5,1.0846736045411545,0.11726097819811082,0.3999492586013628,0.39799510394020565,0.6269431461874003,0.20277184101395362,4981]
["High","Q9UBM7","7-dehydrocholesterol reductase [OS=Homo sapiens]",21,10,65,10,475,54.5,8.7,99.19,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","DHCR7","ENSG00000172893","Vitamin D metabolism; Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol","Steroid biosynthesis; Metabolic pathways",2275.6,2281,2284.8,2208.4,2286.8,2263.9,{"$f":"AVERAGE(T7106:V7106)/AVERAGE(W7106:Y7106)","v":1.0121761773017117},{"$f":"LOG(Z7106,2)","v":0.017460424417647308},{"$f":"TTEST(T7106:V7106,W7106:Y7106,2,2)","v":0.3066056569594928},{"$f":"-LOG10(AB7106)","v":0.5134198365539602},{"$f":"AB7106*7808/AF7106","v":0.5399136151420207},{"$f":"-LOG10(AD7106)","v":0.26767572067379414},4434]
["High","Q9UBP6","tRNA (guanine-N(7)-)-methyltransferase [OS=Homo sapiens]",26,6,13,6,276,31.5,7.64,38.11,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","METTL1","ENSG00000037897","","tRNA modification in the nucleus and cytosol","",614.1,635.5,675.7,681.9,677.4,688.5,0.9401797050493211,-0.08899155639008184,0.08998532613111819,1.0458283050035484,0.2656353219023708,0.5757141767161175,2645]
["High","Q9UBQ6","Exostosin-like 2 [OS=Homo sapiens]",14,3,5,3,330,37.4,8.95,5.45,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EXTL2","ENSG00000162694","","XBP1(S) activates chaperone genes","Glycosaminoglycan biosynthesis; Metabolic pathways",276.7,241.3,302.8,230.4,290.9,256.2,1.0556913183279741,0.07818805570172661,0.5945989867399997,0.22577583521450154,0.7757107583067531,0.11030018529829563,5985]
["High","Q9UBU8-2","Isoform 2 of Mortality factor 4-like protein 1 [OS=Homo sapiens]",38,11,34,9,323,37.2,9.19,90.42,"","","","MORF4L1","","","","",1015.5,1089.9,1027.6,1198.4,1120.3,1180.8,0.8952707529647091,-0.1596040383343018,0.020851364585793168,1.6808655180193517,0.1181476449099224,0.9275749309323232,1378]
["High","Q9UBV8","Peflin [OS=Homo sapiens]",7,2,12,2,284,30.4,6.54,19.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PEF1","ENSG00000162517","","","",373.1,369.5,386.8,445.8,433.2,405.9,0.8789789088645031,-0.1860995466309089,0.015895074982071378,1.7987374190406187,0.10351021306089518,0.9850167974808319,1199]
["High","Q9UDT6-2","Isoform 2 of CAP-Gly domain-containing linker protein 2 [OS=Homo sapiens]",26,25,49,1,1011,111.7,6.83,119.09,"","","","CLIP2","","","","",114.2,113.2,106.3,106.3,118,118.6,0.9731700204141149,-0.03923621775331492,0.5506121995212913,0.25915417048340017,0.7463854260177504,0.12703684924797684,5760]
["High","Q9UDY2","Tight junction protein ZO-2 [OS=Homo sapiens]",33,31,97,1,1190,133.9,7.4,182.97,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","TJP2","ENSG00000119139","1q21.1 copy number variation syndrome","Signaling by Hippo; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Apoptotic cleavage of cell adhesion  proteins","Tight junction; Vibrio cholerae infection",3891.5,3886.6,3909.3,4749.9,4445.8,4686,0.8419285822341644,-0.24823023502381747,1.4026375363749483E-3,2.8530545430057663,0.03156136565998731,1.5008442131380046,347]
["High","Q9UEG4","zinc finger protein 629 [OS=Homo sapiens]",13,7,11,5,869,96.6,7.93,17.83,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF629","ENSG00000102870","","","",207.7,237.6,173.1,219.9,205.6,224.5,0.9513846153846154,-0.07189939887833181,0.6174954959155012,0.20936620585158058,0.7888424136302739,0.1030097467605787,6112]
["High","Q9UG63","ATP-binding cassette sub-family F member 2 [OS=Homo sapiens]",23,15,41,15,623,71.2,7.37,64.83,"transport","","transporter activity;other molecular function","ABCF2","ENSG00000033050","VEGFA-VEGFR2 signaling pathway","","Pathogenic Escherichia coli infection",2365.2,2217.5,2312.9,2501.3,2367.3,2433.1,0.9443828149608995,-0.08255630596403515,0.07997109111136406,1.0970669785055347,0.248078776081657,0.6054103893952619,2517]
["High","Q9UGN5-1","Poly [ADP-ribose] polymerase 2 [OS=Homo sapiens]",3,2,4,2,583,66.2,8.88,5.13,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP2","ENSG00000129484","NAD+ biosynthetic pathways; Base excision repair; Peroxiredoxin 2 induced ovarian failure; DNA repair pathways, full network","Dual Incision in GG-NER; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; HDR through MMEJ (alt-NHEJ); POLB-Dependent Long Patch Base Excision Repair","Base excision repair; Apoptosis",168.3,167.9,176.1,224.5,232.9,226.5,0.7490861237022957,-0.4167964975714257,1.000132081648561E-4,3.9999426414567916,0.010845876796544396,1.9647353332294244,72]
["High","Q9UGU0","Transcription factor 20 [OS=Homo sapiens]",7,12,14,12,1960,211.6,9.04,29.68,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","TCF20","ENSG00000100207; ENSG00000262024; ENSG00000276461; ENSG00000280467; ENSG00000281897; ENSG00000282892; ENSG00000283026; ENSG00000283681","Matrix metalloproteinases","","",878.2,846.3,808,933.9,802.7,833.8,{"$f":"AVERAGE(T7170:V7170)/AVERAGE(W7170:Y7170)","v":0.9852552131963898},{"$f":"LOG(Z7170,2)","v":-0.021430616895549072},{"$f":"TTEST(T7170:V7170,W7170:Y7170,2,2)","v":0.7904907653722825},{"$f":"-LOG10(AB7170)","v":0.10210319919323448},{"$f":"AB7170*7808/AF7170","v":0.893220245445265},{"$f":"-LOG10(AD7170)","v":0.049041441908797494},6910]
["High","Q9UGY1","Nucleolar protein 12 [OS=Homo sapiens]",21,3,5,2,213,24.6,10.23,11.14,"","nucleus","nucleic acid binding activity;other molecular function","NOL12","ENSG00000273899","","Major pathway of rRNA processing in the nucleolus and cytosol","",82.6,54.1,69.8,88.3,66.4,73.3,0.9057017543859649,-0.14289204274529635,0.5314235377121146,0.27455921380962806,0.7301346089136355,0.136597065195723,5683]
["High","Q9UHB7-1","AF4/FMR2 family member 4 [OS=Homo sapiens]",12,10,14,10,1163,127.4,9.31,27.56,"other biological processes","nucleus;other cell component","","AFF4","ENSG00000072364","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",344.3,359.2,382.2,391.7,341,365.7,0.9884377276037873,-0.01677801705340569,0.8286322221345797,0.08163818276454533,0.917074470648731,0.037595396196276595,7055]
["High","Q9UHD2","Serine/threonine-protein kinase TBK1 [OS=Homo sapiens]",24,14,25,14,729,83.6,6.79,68.53,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;kinase activity;other molecular function","TBK1","ENSG00000183735","TNF-alpha signaling pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Toll-like receptor signaling pathway","Negative regulators of DDX58/IFIH1 signaling; Potential therapeutics for SARS; Interleukin-37 signaling; IRF3-mediated induction of type I IFN; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; TICAM1-dependent activation of IRF3/IRF7; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Regulation of innate immune responses to cytosolic DNA; STAT6-mediated induction of chemokines; IRF3 mediated activation of type 1 IFN","Ras signaling pathway; Mitophagy; Autophagy; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; IL-17 signaling pathway; Alcoholic liver disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Shigellosis; Yersinia infection; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis",1121,1153.9,1072.6,1145.1,1165.1,1113.1,0.9778576227616628,-0.03230367254084157,0.4186435339158048,0.37815561222201294,0.6428257055682602,0.19190676482214097,5085]
["High","Q9UHI8","a disintegrin and metalloproteinase with thrombospondin motifs 1 [OS=Homo sapiens]",9,6,8,6,967,105.3,6.83,17.04,"cell organization and biogenesis;protein metabolism;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","other molecular function","ADAMTS1","ENSG00000154734","VEGFA-VEGFR2 signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Malignant pleural mesothelioma","Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins; Degradation of the extracellular matrix","",317.4,338.1,340.1,208.8,225.6,223.5,1.5132998936008513,0.5976979175862862,2.3271384968959302E-4,3.6331777694215655,0.014653465632067276,1.8340596499251653,124]
["High","Q9UHL0-1","ATP-dependent RNA helicase DDX25 [OS=Homo sapiens]",8,2,10,1,483,54.7,6.28,20.64,"other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX25","ENSG00000109832","","","",10.8,15.1,20.7,21.5,27.2,24,0.6409903713892708,-0.6416254092653144,0.05813341417371585,1.2355741701923635,0.20492356562906247,0.6884080960928164,2215]
["High","Q9UHQ4","B-cell receptor-associated protein 29 [OS=Homo sapiens]",27,8,13,8,241,28.3,9.54,25.33,"transport;other biological processes","other membranes;ER/Golgi","","BCAP29","ENSG00000075790; ENSG00000283852","","","",942.3,1037.5,935.6,875.3,877.5,891.1,1.1026892091228866,0.14102622734066497,0.05300345145797924,1.2756958492605346,0.1946617822125597,0.710719304789177,2126]
["High","Q9UHV7","mediator of RNA polymerase II transcription subunit 13 [OS=Homo sapiens]",0,1,1,1,2174,239.1,5.64,2.62,"other biological processes","nucleus","other molecular function","MED13","ENSG00000108510","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",68.7,58.9,60.4,70,59.8,53.1,1.0278840896664843,0.03967758681628303,0.7833630494128239,0.10603691761656737,0.8896725367004114,0.050769815460232286,6875]
["High","Q9UI10-1","translation initiation factor eIF-2B subunit delta [OS=Homo sapiens]",34,13,32,1,523,57.5,9.38,82.69,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF2B4","ENSG00000115211","Translation factors","Recycling of eIF2:GDP","Herpes simplex virus 1 infection",15.1,14.5,16.9,16,15.7,18.6,0.9244532803180915,-0.1133276838101333,0.33970240096550414,0.4689013835910119,0.5718836452649108,0.2426923232343451,4638]
["High","Q9UI95","Mitotic spindle assembly checkpoint protein MAD2B [OS=Homo sapiens]",16,3,5,3,211,24.3,6.52,2.43,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD2L2","ENSG00000116670","Cell cycle","Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Bacterial invasion of epithelial cells",138.8,129.6,151.3,143.7,195.3,154.1,0.851145812208477,-0.23252178961520956,0.2226869181159896,0.6523052951209406,0.4490546117380286,0.3477008390986613,3872]
["High","Q9UIF8-1","Bromodomain adjacent to zinc finger domain protein 2B [OS=Homo sapiens]",1,2,2,2,2168,240.3,6.54,6.12,"cell organization and biogenesis;other biological processes","nucleus","nucleic acid binding activity;other molecular function","BAZ2B","ENSG00000123636","","","",74,90.2,83.2,80.9,84.4,87.4,0.9790265136525522,-0.03058016396840569,0.7442470984420513,0.1282828498395345,0.8700526043772325,0.06045448864563345,6679]
["High","Q9UIJ7-1","GTP:AMP phosphotransferase AK3, mitochondrial [OS=Homo sapiens]",65,13,42,13,227,25.6,9.16,65.5,"other metabolic processes;stress response","mitochondrion;other cell component","kinase activity;other molecular function","AK3","ENSG00000147853; ENSGGOG00000028122","","Factors involved in megakaryocyte development and platelet production","Purine metabolism; Biosynthesis of cofactors",2058.4,1925,2113.7,1848.2,1934.9,1893.2,1.0741327977731974,0.10317236841193797,0.08418591195801868,1.0747605791749508,0.25517220518952244,0.5931666332040899,2576]
["High","Q9UIW2","Plexin-A1 [OS=Homo sapiens]",10,16,21,13,1896,210.9,6.92,39.52,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","PLXNA1","ENSG00000114554","","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Sema3A PAK dependent Axon repulsion; RHOD GTPase cycle; RND1 GTPase cycle; CRMPs in Sema3A signaling; Other semaphorin interactions","Axon guidance",688,655.3,622.9,709.3,633.2,713.2,0.9564625188500269,-0.06421966048082857,0.40548186715790363,0.3920285623389976,0.6311807054961944,0.19984628550302225,5016]
["Medium","Q9UJ99","Cadherin-22 [OS=Homo sapiens]",2,1,4,1,828,89,4.81,0,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CDH22","ENSG00000149654","Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Malignant pleural mesothelioma","","",31.9,35.3,28.6,34.4,34.2,25.6,1.0169851380042463,0.024298596123397048,0.885821894218046,0.05265358977650936,0.9424304878123045,0.025750672817502644,7339]
["High","Q9UJQ4","Sal-like protein 4 [OS=Homo sapiens]",19,14,33,13,1053,112.2,7.47,77.44,"cell cycle OR cell proliferation;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SALL4","ENSG00000101115","Vitamin D receptor pathway; Wnt/beta-catenin signaling pathway in leukemia","Regulation of PTEN gene transcription; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","",1857.7,1887.2,1784.7,2486.9,2293.8,2439.5,0.7658513614581313,-0.38486367779646974,1.0090741889920798E-3,2.9960769024594054,0.028138754527321997,1.5506951291429893,280]
["High","Q9UJU6-2","Isoform 2 of Drebrin-like protein [OS=Homo sapiens]",47,15,51,1,431,48.3,5.05,132.53,"","","","DBNL","","","","",93.6,100,108,96.5,94.1,123.9,0.9589825119236886,-0.06042358849798702,0.7011886458870548,0.15416512490642587,0.8435872029408511,0.0738700170481597,6490]
["High","Q9UJX4","Anaphase-promoting complex subunit 5 [OS=Homo sapiens]",21,11,18,11,755,85,6.87,38.35,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ANAPC5","ENSG00000089053","Cell cycle","Separation of Sister Chromatids; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of APC/C activators between G1/S and early anaphase; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; IL-17 signaling pathway; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection",377.4,349.4,371.4,335.2,353.3,360.2,1.047201296843711,0.06653878901614296,0.21849837761164367,0.6605517833934519,0.4435869298990416,0.3530212586372775,3846]
["High","Q9UJZ1","Stomatin-like protein 2, mitochondrial [OS=Homo sapiens]",67,18,146,18,356,38.5,7.39,292.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","signal transduction activity or receptor binding;other molecular function","STOML2","ENSG00000165283","","Processing of SMDT1","",3153.7,3261.4,3139.6,3096.2,3146.5,3094,1.0233487206400549,0.03329784773182579,0.15952426845068135,0.7971732382966119,0.3691658233737166,0.43277851189108296,3374]
["High","Q9UK58","Cyclin-L1 [OS=Homo sapiens]",9,3,4,3,526,59.6,10.7,9.86,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","enzyme regulator activity","CCNL1","ENSG00000163660","","","",179.5,170.6,182,203.9,185.9,182.8,0.9292699965071604,-0.10583026681639514,0.14346696901516806,0.8432480768093729,0.348317815320408,0.4580243122271511,3216]
["High","Q9UKA9-1","Polypyrimidine tract-binding protein 2 [OS=Homo sapiens]",27,8,38,1,531,57.5,8.66,69.19,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","LOC101350812; PTBP2","ENSANAG00000033752; ENSCSAG00000001494; ENSG00000117569; ENSMMUG00000016130; ENSPANG00000001229; ENSPPYG00000001132","Genes targeted by miRNAs in adipocytes; mRNA processing","","",428.9,453.9,452.7,570.5,622.8,588.8,0.7493967790808598,-0.4161983179329816,0.001013727229142334,2.9940788880152147,0.028068022004054415,1.5517881916759404,282]
["High","Q9UKF6","Cleavage and polyadenylation specificity factor subunit 3 [OS=Homo sapiens]",21,11,23,11,684,77.4,5.6,59.14,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","CPSF3","ENSG00000119203","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript","mRNA surveillance pathway",512.6,458.4,505.8,503.5,569.5,556.7,0.9061790513591458,-0.14213195522741554,0.12612918302275739,0.8991844173173608,0.3229966090658215,0.49080203702410596,3049]
["High","Q9UKK3","Poly [ADP-ribose] polymerase 4 [OS=Homo sapiens]",3,3,3,3,1724,192.5,5.66,3.75,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP4","ENSG00000102699","NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome","Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein","Base excision repair; Apoptosis",38.8,49.1,51.1,44.9,54.9,42.5,0.976809557273366,-0.033850778915612736,0.8479610782959912,0.07162408155131582,0.9258677247007551,0.03345105493355001,7151]
["High","Q9UKM9-2","Isoform 1 of RNA-binding protein Raly [OS=Homo sapiens]",55,14,62,14,290,30.3,9.63,140.27,"","","","RALY","","","","",3078.8,2963,3141.6,2984.4,3262.8,3063.6,0.986316965244662,-0.01987674574690312,0.6869826406942692,0.16305423695200646,0.8335602888175374,0.07906298353377658,6435]
["High","Q9UKU7","Isobutyryl-CoA dehydrogenase, mitochondrial [OS=Homo sapiens]",9,4,5,4,415,45,7.85,8.28,"other metabolic processes","mitochondrion","other molecular function","ACAD8","ENSG00000151498","","Branched-chain amino acid catabolism","Valine, leucine and isoleucine degradation; Metabolic pathways",311.6,288,320.6,270.5,325.3,310.2,1.015673289183223,0.02243640616964747,0.8156712314974635,0.08848485487100549,0.909693040355977,0.041105127864315895,7001]
["High","Q9UKW4","Guanine nucleotide exchange factor VAV3 [OS=Homo sapiens]",4,4,6,3,847,97.7,7.05,14.63,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;cytosol","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","VAV3","ENSG00000134215","Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mesodermal commitment pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; T-cell receptor (TCR) signaling pathway","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOG GTPase cycle; RAC2 GTPase cycle; FCERI mediated Ca+2 mobilization; FCERI mediated MAPK activation; DAP12 signaling; EPH-ephrin mediated repulsion of cells; GPVI-mediated activation cascade; VEGFR2 mediated vascular permeability","Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Yersinia infection; Proteoglycans in cancer; Lipid and atherosclerosis",128.4,138.9,152,173.4,154,155.4,0.8684755592377799,-0.2034428459086313,0.0840851651293814,1.075280618598621,0.2551639989623824,0.5931806001503322,2573]
["High","Q9UL15-1","BAG family molecular chaperone regulator 5 [OS=Homo sapiens]",27,9,18,9,447,51.2,6.05,33.98,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","BAG5","ENSG00000166170","","Regulation of HSF1-mediated heat shock response","",497.9,525.2,493.4,468.1,467.7,497.3,1.058195520200963,0.08160621531911152,0.11718136073757082,0.9311414631693696,0.3108909495884991,0.5073919206103452,2943]
["High","Q9UL63-1","muskelin [OS=Homo sapiens]",21,11,18,11,735,84.7,6.34,26.5,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","MKLN1","ENSG00000128585","Ciliary landscape","","",625,639.1,661.1,647.2,669.9,593.8,1.0074833847925062,0.010756046321368458,0.8574100658237251,0.06681142226457545,0.9307184476507223,0.031181677906726303,7193]
["High","Q9ULD9","zinc finger protein 608 [OS=Homo sapiens]",2,3,6,2,1512,162.1,8.79,11.89,"other biological processes","nucleus","other molecular function","ZNF608","ENSG00000168916","","","",166.4,117.9,135.9,231.7,146.9,186.2,0.7439801699716716,-0.42666392659813396,0.1637012349781106,0.7859480442156971,0.37330001247344846,0.42794199556217727,3424]
["High","Q9ULH1-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",3,3,5,3,1129,125.4,7.31,9.77,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ASAP1","ENSG00000153317","EGF/EGFR signaling pathway; CCL18 signaling pathway","VxPx cargo-targeting to cilium","Endocytosis; Fc gamma R-mediated phagocytosis",62.1,78.8,71.8,60.1,55.7,54.6,1.248239436619718,0.31989469773483376,0.05131297098084062,1.2897728393062,0.19133317928290525,0.7182097119903882,2094]
["High","Q9ULJ7-1","Ankyrin repeat domain-containing protein 50 [OS=Homo sapiens]",5,5,7,5,1429,155.8,6.6,20.17,"transport","other cytoplasmic organelle","","ANKRD50","ENSG00000151458","","","",240.3,259.6,271.4,250,249.1,231.2,1.0561413117896754,0.07880288032011332,0.279622995172964,0.5534271166671161,0.5097586612912685,0.2926353864050501,4283]
["High","Q9ULT8","E3 ubiquitin-protein ligase hectd1 [OS=Homo sapiens]",16,39,61,39,2610,289.2,5.35,119.59,"protein metabolism;other metabolic processes;developmental processes;other biological processes","","other molecular function","HECTD1","ENSG00000092148","","Antigen processing: Ubiquitination & Proteasome degradation","",2668.5,2754.8,2610.8,3027.1,3051.4,3065.9,0.8785814268842134,-0.1867520935505446,1.0326412853780608E-3,2.9860505156887127,0.02839036322616866,1.546829051077115,284]
["High","Q9ULV0","unconventional myosin-Vb [OS=Homo sapiens]",3,6,6,2,1848,213.5,7.2,9.72,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5B","ENSG00000167306","","Vasopressin regulates renal water homeostasis via Aquaporins","Pathogenic Escherichia coli infection",84.4,82.8,99,82.1,83.1,77.7,1.095924248662001,0.13214808127602715,0.2247570742939237,0.6482866298351664,0.4515963036765199,0.34524962144029475,3886]
["High","Q9ULZ3","apoptosis-associated speck-like protein containing a CARD [OS=Homo sapiens]",50,10,31,10,195,21.6,6.34,70.96,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PYCARD","ENSG00000103490","Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling","Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; CLEC7A/inflammasome pathway","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Lipid and atherosclerosis",1282,1334.1,1362.8,1406.9,1586.6,1556.9,0.8744066455696202,-0.19362372922303672,0.0344412092616789,1.4629216084827696,0.15481690380839888,0.8101816222712328,1737]
["High","Q9UM47","Neurogenic locus notch homolog protein 3 [OS=Homo sapiens]",4,8,13,6,2321,243.5,5.39,17.82,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","NOTCH3","ENSG00000074181","Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; OSX and miRNAs in tooth development; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Neovascularisation processes; Osteoblast differentiation and related diseases; Notch signaling pathway","Pre-NOTCH Transcription and Translation; Pre-NOTCH Processing in Golgi; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Pre-NOTCH Processing in the Endoplasmic Reticulum; Defective LFNG causes SCDO3; Noncanonical activation of NOTCH3","Endocrine resistance; Notch signaling pathway; Apelin signaling pathway; Th1 and Th2 cell differentiation; Thyroid hormone signaling pathway; Human papillomavirus infection; Pathways in cancer; MicroRNAs in cancer; Breast cancer",340.4,328.7,338.5,352.3,331.8,343.6,0.9804417631604553,-0.028496155948605457,0.39018369275396375,0.40873088536426166,0.6199744145345847,0.20762623284968834,4914]
["Medium","Q9UN36-1","Protein NDRG2 [OS=Homo sapiens]",4,2,2,1,371,40.8,5.21,3.96,"cell-cell signaling;signal transduction;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","NDRG2","ENSG00000165795","","","",62.9,57.4,66.5,69,65.9,64.5,0.9368104312938818,-0.09417095468853386,0.22908225233485235,0.6400085555578832,0.4578127018762547,0.3393121621240322,3907]
["Low","Q9UNA0","A disintegrin and metalloproteinase with thrombospondin motifs 5 [OS=Homo sapiens]",1,1,1,1,930,101.7,8.85,0,"cell organization and biogenesis;protein metabolism;stress response;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi","signal transduction activity or receptor binding;other molecular function","ADAMTS5","ENSG00000154736","Vitamin D receptor pathway; Endochondral ossification; IL-18 signaling pathway; Endochondral ossification with skeletal dysplasias","Degradation of the extracellular matrix; Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins","",411.1,215.2,404,263,408,316.8,1.0430249038266857,0.060773604835942775,0.8627156670235419,0.06413231504883565,0.9320719424546582,0.030550565108206074,7227]
["High","Q9UNE7-1","E3 ubiquitin-protein ligase CHIP [OS=Homo sapiens]",29,8,13,8,303,34.8,5.87,33.16,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","STUB1","ENSCATG00000030791; ENSCSAG00000012299; ENSG00000103266; ENSGGOG00000043504; ENSMFAG00000031388; ENSMNEG00000033024; ENSPPAG00000028029; ENSPPYG00000006921; ENSPTRG00000007553; ENSRBIG00000029383; ENSRROG00000037882","Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway; Androgen receptor signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Downregulation of TGF-beta receptor signaling","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",540.4,514.8,467.4,513.9,456.7,471,1.0561875693673697,0.07886606705069212,0.3807564778707482,0.4193526992077079,0.6100854872183052,0.21460930593036714,4873]
["High","Q9UNL2","Translocon-associated protein subunit gamma [OS=Homo sapiens]",15,4,14,4,185,21.1,9.61,35.32,"transport","other membranes;ER/Golgi","","SSR3","ENSG00000114850","VEGFA-VEGFR2 signaling pathway","SRP-dependent cotranslational protein targeting to membrane","Protein processing in endoplasmic reticulum",641.9,557,627.4,554.9,559.8,517.4,1.118987807119662,0.16219431629300735,0.09278602226977734,1.0325174430518618,0.27103376800689166,0.5669765971497637,2673]
["High","Q9UNN8","Endothelial protein C receptor [OS=Homo sapiens]",5,1,3,1,238,26.7,7.18,4.91,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","PROCR","ENSG00000101000","","Cell surface interactions at the vascular wall; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",19.3,25.7,24.9,37.7,41.4,38.3,0.5954003407155026,-0.7480680477346155,2.3981035987943977E-3,2.6201320591800883,0.04026751161158421,1.3950452074114066,465]
["High","Q9UNY4-1","transcription termination factor 2 [OS=Homo sapiens]",27,25,46,25,1162,129.5,8.37,93.56,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","TTF2","ENSG00000116830","Thyroid stimulating hormone (TSH) signaling pathway; Thyroid hormones production and peripheral downstream signaling effects","","Thyroid hormone synthesis",1576.8,1622.3,1623.4,1700.7,1670.2,1683.4,0.9541380606612192,-0.06773006029150097,0.012039314281428938,1.9193982483167604,0.08935643147281097,1.0488741834758455,1052]
["High","Q9UPN9-1","E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",34,27,62,2,1127,122.5,6.67,131.34,"protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TRIM33","ENSG00000197323","Ectoderm differentiation","Downregulation of SMAD2/3:SMAD4 transcriptional activity","",2599.8,2637.9,2651.7,2825.6,2766.3,2800.2,0.9400984259005495,-0.08911628370887946,1.9331359850074251E-3,2.713737594775835,0.036283475410908594,1.4402911207439422,416]
["High","Q9UPN9-2","Isoform Beta of E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",33,26,63,1,1110,120.5,6.67,137.02,"","","","TRIM33","","","","",173,169.6,164.8,179.3,181.5,154.5,0.9846691247816808,-0.022289073089089412,0.783861980079832,0.10576039977289275,0.8898508782296203,0.05068276660025201,6878]
["High","Q9UPT8","Zinc finger CCCH domain-containing protein 4 [OS=Homo sapiens]",18,15,42,14,1303,140.2,6.27,67.32,"other biological processes","cytosol;nucleus","other molecular function","ZC3H4","ENSG00000130749","","","",1006,858.2,947.1,1307.1,1024,1127.4,0.8128668497903716,-0.2989090413314226,0.08160296359972051,1.0882940685545537,0.2507500746897354,0.6007589289462876,2541]
["High","Q9UPX8","SH3 and multiple ankyrin repeat domains protein 2 [OS=Homo sapiens]",5,7,7,7,1470,158.7,6.9,10.03,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","SHANK2","ENSG00000162105","","Neurexins and neuroligins","Glutamatergic synapse",311.9,265.7,321.4,375.1,311.3,312.2,0.9002603645103141,-0.15158579092828345,0.2898604149357071,0.537811090436057,0.5224446259967684,0.2819597337307044,4332]
["High","Q9UPY8","Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",10,3,7,1,281,32,5.54,11.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAPRE3","ENSG00000084764","","","",97.6,105.6,138.2,118.7,134.9,131.4,0.8867532467532466,-0.17339538744188818,0.33771661311110196,0.47144757482501326,0.5700154161633126,0.24411339860097844,4626]
["High","Q9UQB3-1","Catenin delta-2 [OS=Homo sapiens]",3,3,3,3,1225,132.6,7.74,2.46,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","CTNND2","ENSG00000169862; ENSPTRG00000016731","Ectoderm differentiation; Ectoderm differentiation","","Wnt signaling pathway",37.3,49.1,40.7,44.2,48.1,48.6,0.9020581973030518,-0.14870758130467768,0.28970132095736506,0.538049524529802,0.522399056359147,0.2819976162245321,4330]
["High","Q9Y217-1","Myotubularin-related protein 6 [OS=Homo sapiens]",8,4,6,4,621,71.9,7.66,13.34,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","MTMR6","ENSG00000139505; ENSPPAG00000035079","","Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",173.9,193,156.3,231.8,215.4,233.3,0.7688464364437914,-0.3792326208932744,0.012140075865691184,1.9157785992617418,0.08993331343388687,1.046079405479634,1054]
["High","Q9Y230","RuvB-like 2 [OS=Homo sapiens]",62,26,112,26,463,51.1,5.64,212.05,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","RUVBL2","ENSG00000183207","","HATs acetylate histones; Telomere Extension By Telomerase","",5379.8,5182.2,5435.3,4957.2,5298.5,4988.3,1.0494161637365522,0.0695869165179601,0.13271960862320442,0.8770649076726144,0.3332073003633377,0.47728549204081644,3110]
["High","Q9Y250","Leucine zipper putative tumor suppressor 1 [OS=Homo sapiens]",17,8,9,8,596,66.6,7.09,14.92,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;other cell component","cytoskeletal activity","LZTS1","ENSG00000061337","","","",319.3,321.3,312.5,454.7,340.2,348.4,0.8336394647074259,-0.2625045180986755,0.16152910841824988,0.791749204067802,0.371493160097112,0.4300491780256871,3395]
["High","Q9Y277","Voltage-dependent anion-selective channel protein 3 [OS=Homo sapiens]",51,12,51,10,283,30.6,8.66,130.66,"transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","VDAC3","ENSG00000078668","Alzheimer's disease and miRNA effects; Ferroptosis; Hepatitis B infection; Alzheimer's disease","Ub-specific processing proteases; Mitochondrial calcium ion transport","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Hepatitis B; Human T-cell leukemia virus 1 infection; Viral carcinogenesis; Chemical carcinogenesis; Diabetic cardiomyopathy",1986.3,2040.4,2359.2,1689.9,2199.8,2002.9,1.0837151681770356,0.11598562435292789,0.4325198786222973,0.36399392755736804,0.6537195532874366,0.184608524736031,5166]
["High","Q9Y282-1","Endoplasmic reticulum-Golgi intermediate compartment protein 3 [OS=Homo sapiens]",24,10,20,10,383,43.2,6.06,39.07,"transport","other membranes;ER/Golgi;other cell component","","ERGIC3","ENSCANG00000036642; ENSCATG00000041920; ENSG00000125991; ENSGGOG00000027615; ENSMFAG00000037850; ENSMLEG00000032774; ENSMNEG00000030061; ENSPANG00000011730; ENSPPAG00000037078; ENSPTRG00000013442; ENSRROG00000033106","","","",662.7,975.9,693.8,732.2,745.9,739.5,1.0517676767676767,0.0728160652859379,0.720644129786993,0.14227914668728162,0.855785454810166,0.0676350991904417,6575]
["High","Q9Y2B1","UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase [OS=Homo sapiens]",5,2,2,2,443,51.1,8.32,4.19,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus","other molecular function","RXYLT1","ENSG00000118600","","","Mannose type O-glycan biosynthesis; Metabolic pathways",141.3,144.5,137.3,131.7,123.3,139.8,1.0716818642350558,0.09987669589995288,0.143791007800764,0.8422682723997059,0.3486708661206104,0.45758433943690136,3220]
["High","Q9Y2F5","Little elongation complex subunit 1 [OS=Homo sapiens]",4,7,7,7,2266,247.7,5.48,11.53,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","ICE1","ENSG00000164151","","RNA polymerase II transcribes snRNA genes","",221.4,180.1,176.9,175.2,191.7,180.7,1.056245434623813,0.07894510569321829,0.5346051363389991,0.27196687297759503,0.7323152464096325,0.13530192399145097,5700]
["High","Q9Y2G8","DnaJ homolog subfamily C member 16 [OS=Homo sapiens]",16,8,14,8,782,90.5,7.12,37.2,"","other membranes","","DNAJC16","ENSG00000116138","","","",452.3,488.2,537.5,470.6,453.3,486.1,1.04822695035461,0.06795110685999514,0.4397869941918607,0.356757618163555,0.6588366942920277,0.18122222054546663,5212]
["Medium","Q9Y2I8","WD repeat-containing protein 37 [OS=Homo sapiens]",1,1,1,1,494,54.6,7.23,2.3,"","nucleus;other cell component","","WDR37","ENSG00000047056","","","",103.2,87.7,96.8,123.8,92.6,99.7,0.9101550142360012,-0.13581581416521157,0.4165507663674719,0.38033206218107835,0.6412516529568653,0.19297150239611924,5072]
["High","Q9Y2J4","Angiomotin-like protein 2 [OS=Homo sapiens]",6,4,4,4,779,85.7,7.3,6.13,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","AMOTL2","ENSG00000114019","","Signaling by Hippo","Tight junction",223.1,197.9,183.5,164.7,135.5,160.4,1.3124185844550587,0.39222792834364034,0.031140027475078092,1.5066810085864746,0.14498588820835406,0.8386742665339249,1677]
["High","Q9Y2R0","Cytochrome c oxidase assembly factor 3 homolog, mitochondrial [OS=Homo sapiens]",26,3,6,3,106,11.7,9.6,12.73,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion","","COA3","ENSG00000183978","Mitochondrial complex IV assembly","","Thermogenesis",231.9,206.7,180.2,201.8,219.1,201.9,0.993577392421323,-0.009295747630001351,0.9375721537845191,0.027995299829945107,0.9690976140785709,0.013632475662815976,7554]
["High","Q9Y2R9","28S ribosomal protein S7, mitochondrial [OS=Homo sapiens]",17,3,5,3,242,28.1,9.99,8.48,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS7","ENSG00000125445","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",246.2,300.7,247.3,291,239.7,233.2,1.0396648776017803,0.05611856939014552,0.7137905161853741,0.14642922661813002,0.8514018255996642,0.06986542293148011,6546]
["High","Q9Y2V7-1","Conserved oligomeric Golgi complex subunit 6 [OS=Homo sapiens]",10,7,11,7,657,73.2,5.76,22.47,"other metabolic processes;transport","other membranes;ER/Golgi","","COG6","ENSG00000133103","","COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",479.2,463.9,528.4,453.7,555.3,503.2,0.9730855706917074,-0.039361417337948096,0.7195445940726889,0.1429422853138328,0.854999876810159,0.06803394784571277,6571]
["High","Q9Y2Y0","ADP-ribosylation factor-like protein 2-binding protein [OS=Homo sapiens]",34,5,13,5,163,18.8,4.35,32,"signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","ARL2BP","ENSG00000102931","Ciliopathies","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane","",379.5,410.5,445.1,415.8,399.3,366.9,1.0449238578680202,0.06339781897753058,0.49795049951937026,0.3028138276300099,0.7043473732331962,0.15221310070057342,5520]
["Low","Q9Y2Z2","Protein MTO1 homolog, mitochondrial [OS=Homo sapiens]",1,1,1,1,717,79.9,8.31,0,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","MTO1","ENSG00000135297","","tRNA modification in the mitochondrion","",15.5,14.8,10.8,18.4,15.4,18.1,0.791907514450867,-0.336596144676198,0.10842443944112638,0.9648728144939794,0.29590283927169336,0.5288508676406067,2861]
["High","Q9Y2Z4","Tyrosine--tRNA ligase, mitochondrial [OS=Homo sapiens]",45,17,69,17,477,53.2,8.98,146.02,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","YARS2","ENSG00000139131","Orexin receptor pathway","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",2350.4,2437.6,2546.1,2482.8,2645.9,2555.6,0.9544265580469268,-0.06729390660117267,0.18831727934365208,0.7251098287921347,0.40372908212938924,0.39390996559240044,3642]
["Medium","Q9Y2Z9-1","Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [OS=Homo sapiens]",2,1,1,1,468,50.8,7.3,0,"other metabolic processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","COQ6","ENSG00000119723","Nephrotic syndrome","Ubiquinol biosynthesis","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",40.4,46,46.7,41.1,45.2,42.8,1.0309837335398917,0.0440215706047013,0.5964759491083753,0.2244070631086399,0.7769910261324982,0.10958399705963047,5994]
["High","Q9Y303","N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",16,5,6,5,409,43.7,6.7,13.48,"other metabolic processes","cytosol","other molecular function","AMDHD2","ENSG00000162066","","Synthesis of UDP-N-acetyl-glucosamine","Amino sugar and nucleotide sugar metabolism; Metabolic pathways",169.7,156.9,170.3,208.8,215.4,176.8,0.8267886855241265,-0.2744094490484377,0.05227046101447812,1.2817436694993225,0.193150856413178,0.7141033618930005,2113]
["High","Q9Y305-1","Acyl-coenzyme A thioesterase 9, mitochondrial [OS=Homo sapiens]",31,12,33,12,439,49.9,8.6,73.44,"other metabolic processes","mitochondrion","other molecular function","ACOT9","ENSG00000123130","VEGFA-VEGFR2 signaling pathway","Mitochondrial Fatty Acid Beta-Oxidation","",1127.3,1236.9,1166.1,1140.4,1213.4,1196.2,0.9944507042253522,-0.00802823768686624,0.8742099532008087,0.05838425321632606,0.9360712170312554,0.02869110854062937,7292]
["High","Q9Y312","Protein AAR2 homolog [OS=Homo sapiens]",29,8,27,8,384,43.4,5.96,31.97,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","","AAR2","ENSG00000131043","Ciliary landscape","","",475.3,448.5,465.2,418.8,379.8,402.4,1.1565362198168194,0.20981044827575862,0.0103406929587051,1.9854503569811577,0.08264087064643748,1.0828051160412953,977]
["High","Q9Y314","nitric oxide synthase-interacting protein [OS=Homo sapiens]",47,9,14,9,301,33.2,8.82,34.49,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","NOSIP","ENSG00000142546","","NOSIP mediated eNOS trafficking","",510.8,549.8,511.7,493.9,478.2,470.3,1.0900582362728788,0.12440521292673061,0.04135589478183073,1.3834625782817158,0.17139428155867004,0.7660036720799389,1884]
["High","Q9Y315","deoxyribose-phosphate aldolase [OS=Homo sapiens]",31,9,19,9,318,35.2,8.94,32.66,"other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","DERA","ENSG00000023697","Pentose phosphate pathway in senescent cells","Neutrophil degranulation; Pentose phosphate pathway","Pentose phosphate pathway; Metabolic pathways",701.9,705.3,735.9,704.3,767.4,756.5,0.9618077371869672,-0.05617956297986871,0.2717750051759107,0.5657904873140793,0.5023719792645621,0.2989745921811998,4224]
["High","Q9Y316-1","Protein MEMO1 [OS=Homo sapiens]",21,5,11,5,297,33.7,7.14,22.28,"other biological processes","","other molecular function","LOC111154137; LOC114499315; MEMO1","ENSANAG00000021250; ENSCANG00000020056; ENSCATG00000030724; ENSCCAG00000037443; ENSCHIG00000006439; ENSCJAG00000003208; ENSDLEG00000015222; ENSECAG00000019946; ENSFCAG00000001385; ENSG00000162959; ENSHGLG00000018935; ENSMMUG00000003908; ENSMNEG00000040106; ENSMODG00000047380; ENSPANG00000022798; ENSPCOG00000018130; ENSPCTG00005009736; ENSPTRG00000050445; ENSRFEG00010015180; ENSSSCG00000008515; ENSSSCG00070008027; ENSVURG00010020209; ENSVVUG00000007616","","ERBB2 Regulates Cell Motility; ERBB2 Regulates Cell Motility","",508.2,534.8,515.6,587.9,533.6,570,0.921430682825894,-0.11805245567788339,0.06791627236033264,1.1680261587146983,0.22365679231947586,0.650417908034251,2371]
["High","Q9Y320","Thioredoxin-related transmembrane protein 2 [OS=Homo sapiens]",29,7,29,7,296,34,8.69,56.44,"developmental processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","TMX2","ENSG00000213593","","","",1363.5,1343.6,1419.2,1353.1,1503.5,1405.1,0.9682286411525918,-0.04658032372344824,0.41402279522653884,0.38297574687774283,0.6389978227176942,0.19450062162767479,5059]
["High","Q9Y324","rRNA-processing protein FCF1 homolog [OS=Homo sapiens]",10,2,3,2,198,23.4,9.7,7.51,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","FCF1","ENSG00000119616","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",126.7,138.8,111,112.3,112.1,111.1,1.1222056631892698,0.16633709847174477,0.16504360306255333,0.7824013038600122,0.37515588143010664,0.42578824059694603,3435]
["High","Q9Y333","U6 snRNA-associated Sm-like protein LSm2 [OS=Homo sapiens]",67,5,22,5,95,10.8,6.52,32.21,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM2","ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",640.3,678.9,795.5,605.4,915.7,753.1,0.9298654471902208,-0.10490612352190642,0.6265323996917674,0.20305646554210782,0.7947952846130496,0.09974471815080753,6155]
["High","Q9Y365","START domain-containing protein 10 [OS=Homo sapiens]",4,1,1,1,291,33,7.12,3.13,"transport","other membranes;cytosol;cytoskeleton;other cell component","other molecular function","STARD10","ENSG00000214530","","Synthesis of PC","",15.3,12,14.8,15.4,14.9,14.1,0.9481981981981983,-0.07673944328370975,0.5222099668728807,0.28215484351156855,0.722561655386045,0.14112508912297453,5643]
["High","Q9Y366","Intraflagellar transport protein 52 homolog [OS=Homo sapiens]",9,2,4,2,437,49.7,5.26,10.33,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","IFT52","ENSG00000101052","Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",35.7,37.2,47.2,38.8,39.6,38.4,1.0282534246575343,0.04019587682561699,0.7767715195894249,0.10970670626161898,0.8868302419877512,0.052159505336013434,6839]
["High","Q9Y371","Endophilin-B1 [OS=Homo sapiens]",36,11,39,10,365,40.8,6.04,80.37,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GLB1","ENSG00000097033","Nanoparticle triggered autophagic cell death","","Autophagy; Endocytosis",1885.4,1869.3,1809.8,2033.9,1987.2,2004.3,0.9235071530520794,-0.11480495919908967,0.004544502205571804,2.3425136814658423,0.05311897188788121,1.2747503392827526,668]
["High","Q9Y375","Complex I intermediate-associated protein 30, mitochondrial [OS=Homo sapiens]",33,9,17,9,327,37.7,7.64,48.38,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion","other molecular function","NDUFAF1","ENSG00000137806","Mitochondrial immune response to SARS-CoV-2","Complex I biogenesis","Thermogenesis",667.2,716.9,700.5,641,628.4,629.4,1.0978512744891509,0.13468262621027166,0.0150656473069672,1.8220122037978224,0.10045480288027318,0.99802929421155,1171]
["High","Q9Y376","Calcium-binding protein 39 [OS=Homo sapiens]",36,13,28,12,341,39.8,6.89,47.44,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CAB39","ENSG00000135932","AMP-activated protein kinase (AMPK) signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias","Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK","mTOR signaling pathway; AMPK signaling pathway",1588.1,1622.8,1675.7,1482.3,1566.7,1514.2,1.0708713183730716,0.09878512854864917,0.038249202656778315,1.4173776137226677,0.16355409328812984,0.7863385822623125,1826]
["High","Q9Y383","Putative RNA-binding protein Luc7-like 2 [OS=Homo sapiens]",41,19,111,13,392,46.5,10.01,244.56,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","LUC7L2","ENSG00000146963","","","",5046.7,5129.9,4917.3,5251.5,4803.1,5112.2,0.9951934488488013,-0.006951106348563854,0.8760758304603034,0.0574583009949907,0.9370411074293217,0.028241356456811223,7300]
["High","Q9Y388","RNA-binding motif protein, X-linked 2 [OS=Homo sapiens]",10,4,10,4,322,37.3,9.83,19.58,"RNA metabolism OR transcription;other metabolic processes","nucleus","","RBMX2","ENSG00000134597","","","",479.9,496.5,501.4,593.6,600.6,585.1,0.8305513404147697,-0.26785874395140336,2.1992177182613912E-4,3.6577317742048967,0.014803010296711158,1.8296499587731796,116]
["High","Q9Y394","Dehydrogenase/reductase SDR family member 7 [OS=Homo sapiens]",9,2,3,2,339,38.3,8.32,2.66,"","","other molecular function","DHRS7","ENSG00000100612","","","",119.6,132.8,113.3,117.6,101.1,133.2,1.0392156862745097,0.055495112591703394,0.694813597746333,0.1581316908461066,0.8394096505033836,0.07602604211014398,6463]
["High","Q9Y399","28S ribosomal protein S2, mitochondrial [OS=Homo sapiens]",18,6,9,6,296,33.2,9.26,9.57,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS2","ENSG00000122140","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",365.6,309.9,330.1,353,377.8,342,0.9373601789709173,-0.09332458748396606,0.312957329475377,0.5045148727943839,0.546904840766281,0.26208823257932,4468]
["High","Q9Y3A3","MOB-like protein phocein [OS=Homo sapiens]",46,7,35,7,225,26,5.78,49.95,"","other membranes;ER/Golgi;other cell component","other molecular function","MOB4","ENSG00000115540","","","",773.5,805,835.5,772.4,925.9,797.8,0.967108689555707,-0.04825005723148642,0.6184177422009385,0.20871805914563138,0.7896329895510921,0.10257471585930023,6115]
["High","Q9Y3A4","Ribosomal RNA-processing protein 7 homolog A [OS=Homo sapiens]",29,7,16,7,280,32.3,9.58,27.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","","RRP7A","ENSG00000189306","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",804.1,852.7,714.3,866.3,783.4,707.9,1.0057261621988465,0.008237543496655725,0.9448438494982607,0.024639959643882745,0.972494170430058,0.012112993352019052,7586]
["High","Q9Y3A5","Ribosome maturation protein SBDS [OS=Homo sapiens]",61,20,70,20,250,28.7,8.75,104.87,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity","SBDS","ENSG00000126524","","","Ribosome biogenesis in eukaryotes",4032.1,3889.2,3968.3,3269.7,3450.3,3262.6,1.1910323963696832,0.2522126553903018,1.010561702807726E-3,2.9954371642161624,0.028079949379084427,1.551603679462607,281]
["High","Q9Y3A6-1","Transmembrane emp24 domain-containing protein 5 [OS=Homo sapiens]",12,3,5,3,229,26,4.84,9.42,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED5","ENSG00000117500","","WNT ligand biogenesis and trafficking","",232.9,218,216.9,200.8,214,228.5,1.0380848748639826,0.05392440471647705,0.4392944227497319,0.3572443104710588,0.6586042344143446,0.181375481372559,5208]
["High","Q9Y3B2","Exosome complex component csl4 [OS=Homo sapiens]",24,3,8,3,195,21.4,8.24,24.08,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EXOSC1","ENSG00000171311","","Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","RNA degradation",264.7,264.5,291.2,226.1,336.5,297.7,0.9536208299430433,-0.06851234595041349,0.7118612656131027,0.14760463761244508,0.8510507980258928,0.07004451671456648,6531]
["High","Q9Y3B3-1","Transmembrane emp24 domain-containing protein 7 [OS=Homo sapiens]",25,5,15,5,224,25.2,6.89,25.06,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED7","ENSG00000134970; ENSPTRG00000017152","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",738,712.7,865.1,587.8,822.7,773.1,1.0605422238505222,0.08480206068657127,0.6339615215239706,0.19793710094624922,0.7995431368210568,0.09715810030051869,6191]
["High","Q9Y3B4","Splicing factor 3B subunit 6 [OS=Homo sapiens]",34,4,4,4,125,14.6,9.38,8.97,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","SF3B6","ENSG00000115128","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",224.4,216.8,211.2,302.4,227.9,210.3,0.8809073724007563,-0.18293776745974522,0.36034041007405665,0.44328703155469645,0.5939493185261209,0.2262506116240177,4737]
["High","Q9Y3B6","ER membrane protein complex subunit 9 [OS=Homo sapiens]",8,1,1,1,208,23,5.91,3.52,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC9","ENSG00000100908; ENSG00000285377","","","",19.3,14.7,18.4,24.6,17.1,18.3,0.8733333333333333,-0.19539568895843068,0.4041732418047026,0.3934324422339646,0.6302745500321786,0.2004702289742383,5007]
["High","Q9Y3B7-1","39S ribosomal protein L11, mitochondrial [OS=Homo sapiens]",43,9,19,9,192,20.7,9.91,33.13,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL11","ENSG00000174547; ENSPPAG00000028194; ENSPTRG00000003924","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",982.3,948.9,950.4,899.6,984.1,988.8,1.0031679721496953,4.5631934854379564E-3,0.9266668116002827,0.033076390876552224,0.9640792091905407,0.015887282797206005,7505]
["High","Q9Y3B8-1","Oligoribonuclease, mitochondrial [OS=Homo sapiens]",34,6,27,6,237,26.8,6.87,49.9,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","REXO2","ENSG00000076043; ENSPPAG00000039849; ENSPTRG00000004306","","","Ribosome biogenesis in eukaryotes",958.2,993.2,840.3,1286.3,1023.5,1028.2,0.8363391252246853,-0.2578400388572944,0.13782354476486017,0.8606765844023131,0.3394719992189364,0.4691960419614291,3170]
["High","Q9Y3B9","RRP15-like protein [OS=Homo sapiens]",18,5,23,5,282,31.5,5.52,39.06,"RNA metabolism OR transcription;other metabolic processes","other cell component","","RRP15","ENSG00000067533","","","",953.8,1007.8,902.6,1208.6,1025.6,1004.2,0.8844491106719369,-0.17714895919982776,0.1565471816966935,0.805354746536953,0.3647628751679447,0.4379893697135891,3351]
["High","Q9Y3C0","WASH complex subunit 3 [OS=Homo sapiens]",17,2,2,2,194,21.2,4.46,0,"cell organization and biogenesis;transport","other cytoplasmic organelle;other cell component","","WASHC3","ENSG00000120860","","","Endocytosis",27.3,22.6,25.8,24,18.1,23.1,1.1610429447852761,0.2154213357546542,0.2026883019076606,0.6931713157547285,0.42337888210139485,0.3732708081389063,3738]
["High","Q9Y3C1","nucleolar protein 16 [OS=Homo sapiens]",17,3,6,3,178,21.2,9.94,8.83,"other biological processes","nucleus;other cell component","","NOP16","ENSG00000048162","","","",261.8,256.5,282.4,410.1,273.7,258.7,0.849549071618037,-0.2352308121802665,0.38764980401095894,0.4115604312662023,0.6173301386329936,0.20948251985374514,4903]
["High","Q9Y3C4","EKC/KEOPS complex subunit TPRKB [OS=Homo sapiens]",14,2,9,2,175,19.6,6.79,12.12,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","TPRKB","ENSG00000144034","","tRNA modification in the nucleus and cytosol","",211.5,237.8,214.1,229,231.6,235.3,0.9532978876275325,-0.06900099528532411,0.2745715942974885,0.561344394549971,0.5049116835315097,0.2967845797213156,4246]
["High","Q9Y3C5","Ring finger protein 11 [OS=Homo sapiens]",8,1,2,1,154,17.4,4.78,3.26,"protein metabolism;other metabolic processes","nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","RNF11","ENSG00000123091","","","",56.1,57.3,55.6,56.6,52.1,50.1,1.0642317380352644,0.08981233402658875,0.16225702299560937,0.7897964964861092,0.3720713173420611,0.4293738080762777,3405]
["High","Q9Y3C6","Peptidyl-prolyl cis-trans isomerase-like 1 [OS=Homo sapiens]",40,6,42,6,166,18.2,7.99,66.58,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","PPIL1","ENSG00000137168","","mRNA Splicing - Major Pathway","Spliceosome",2268.1,2222.2,2128.1,2439.8,2294.7,2322.2,0.9378888148851446,-0.0925111910394482,0.07362774041759142,1.1329585275041398,0.2352231576025179,0.6285199244160211,2444]
["High","Q9Y3C8","ubiquitin-fold modifier-conjugating enzyme 1 [OS=Homo sapiens]",26,5,12,5,167,19.4,7.4,25.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes","","other molecular function","UFC1","ENSG00000143222","","","",469.3,460.5,475.7,535.4,529.7,482,0.9084739189451233,-0.13848299765266778,0.054203532951627706,1.2659724055023518,0.19758225270135815,0.7042520673395531,2142]
["High","Q9Y3D0","Mitotic spindle-associated MMXD complex subunit MIP18 [OS=Homo sapiens]",26,2,2,2,163,17.7,5.19,7.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CIAO2B","ENSG00000166595","","Cytosolic iron-sulfur cluster assembly","",54.7,55.1,49.2,62.7,38.3,34.6,1.172566371681416,0.22966958703537405,0.435868604585068,0.36064441188735485,0.6563668398457495,0.18285336795377918,5185]
["High","Q9Y3D2","Methionine-R-sulfoxide reductase B2, mitochondrial [OS=Homo sapiens]",21,2,3,2,182,19.5,8.63,5.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","MSRB2","ENSG00000148450","Sulindac metabolic pathway; Methionine de novo and salvage pathway","Protein repair","",43.7,40.6,37.1,31.4,25.4,36.3,1.3039742212674545,0.3829153486968886,0.06257825065905495,1.2035765814860577,0.21327410787686646,0.6710618660168198,2291]
["High","Q9Y3D3","28S ribosomal protein S16, mitochondrial [OS=Homo sapiens]",23,2,4,2,137,15.3,9.5,7.77,"protein metabolism;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","other molecular function","MRPS16","ENSG00000182180","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",90.9,96.4,85.4,93.9,83.2,79.8,1.0615025301673804,0.08610781001444652,0.3769235504204046,0.42374672671038094,0.6069331989446317,0.2168591061672699,4849]
["High","Q9Y3D6","mitochondrial fission 1 protein [OS=Homo sapiens]",12,2,9,2,152,16.9,8.79,17.75,"cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FIS1","ENSG00000214253","CAMKK2 pathway","Class I peroxisomal membrane protein import","Mitophagy",309.1,296.4,294.3,266,300.8,312.1,1.0237797246558198,0.033905340013772066,0.658621204309731,0.18136429128814585,0.815624799881107,0.08850957753861088,6305]
["High","Q9Y3D8","Adenylate kinase isoenzyme 6 [OS=Homo sapiens]",56,5,10,5,172,20,4.58,15.84,"other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AK6","ENSG00000085231; ENSG00000279247","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Metabolic pathways; Biosynthesis of cofactors; Ribosome biogenesis in eukaryotes",212.7,250.3,238.7,268.6,292.7,259.7,0.8546894031668696,-0.22652785959158353,0.05542622026007908,1.256284736709007,0.19952417141110995,0.700004484064565,2169]
["High","Q9Y3D9","28S ribosomal protein S23, mitochondrial [OS=Homo sapiens]",11,2,3,2,190,21.8,8.9,7.9,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS23","ENSG00000181610","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",205.7,219.7,177.8,243,214.6,198,0.9200732153752289,-0.12017942583079438,0.38699985605274717,0.4122891965198721,0.6166724236856836,0.20994547188975038,4900]
["High","Q9Y3E0","vesicle transport protein GOT1B [OS=Homo sapiens]",17,3,44,3,138,15.4,10.36,91.96,"transport","other membranes;ER/Golgi;other cell component","","GOLT1B","ENSG00000111711","","","",2257.5,2483,2417.5,2581.7,2585.7,2482.8,0.935661812763065,-0.09594092107537024,0.09380772495363436,1.0277613965186287,0.2725905159798947,0.5644892582931618,2687]
["High","Q9Y3E1","Hepatoma-derived growth factor-related protein 3 [OS=Homo sapiens]",30,5,21,4,203,22.6,7.99,36.17,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","HDGFL3","ENSG00000166503","","","",663.1,692,695.2,706.2,749.3,733.1,0.9368089189436171,-0.09417328372108431,0.046536523853830246,1.332206060402157,0.1820426744743019,0.7398267926948738,1996]
["High","Q9Y3E5","Peptidyl-tRNA hydrolase 2, mitochondrial [OS=Homo sapiens]",21,2,5,2,179,19.2,8.73,12.87,"other biological processes","cytosol;mitochondrion","other molecular function","PTRH2","ENSG00000141378","Apoptosis modulation and signaling","Ub-specific processing proteases","",175.9,145.3,156.8,142.9,143.2,139,1.1244413079275464,0.1692083592289361,0.12244094340071215,0.9120733328467946,0.3183546074168367,0.4970888603871403,3003]
["High","Q9Y3E7","Charged multivesicular body protein 3 [OS=Homo sapiens]",9,2,4,2,222,25.1,5.12,5.58,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","CHMP3","ENSG00000115561","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Endocytosis; Necroptosis",59.3,63.6,75.9,68.2,74.9,74.1,0.9152854511970533,-0.12770634624207555,0.3197979364571105,0.49512434292931334,0.5526742558338024,0.25753076485502213,4518]
["High","Q9Y3F4","Serine-threonine kinase receptor-associated protein [OS=Homo sapiens]",68,21,239,21,350,38.4,5.12,565.03,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","STRAP","ENSG00000023734","TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer","Downregulation of TGF-beta receptor signaling","",8463,8965.7,8305.6,8540.5,8463,8673.1,1.0022471822593335,3.2383614685284725E-3,0.9308692252721311,0.031111327323653612,0.9654924164352816,0.015251133084218695,7528]
["High","Q9Y3I0","tRNA-splicing ligase RtcB homolog [OS=Homo sapiens]",56,25,115,25,505,55.2,7.23,254.71,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","RTCB","ENSG00000100220","Unfolded protein response","tRNA processing in the nucleus","",5708.1,5435,5655.4,5732.9,5701.4,5797.7,0.9748433147632312,-0.03675773979882541,0.17715335283511396,0.751650623720252,0.38930857836661126,0.40970602655094457,3553]
["High","Q9Y3L3-1","SH3 domain-binding protein 1 [OS=Homo sapiens]",15,8,16,8,701,75.7,6.77,35.16,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SH3BP1","ENSG00000100092","","RAC1 GTPase cycle","",562.8,563.3,573.1,662.6,614.5,642.8,0.8850460961508413,-0.1761754973681658,6.862284634691935E-3,2.163531272185942,0.06550210076732839,1.1837447711986298,818]
["High","Q9Y3M8-4","Isoform 4 of StAR-related lipid transfer protein 13 [OS=Homo sapiens]",3,3,3,2,1078,120.6,6.95,8.94,"","","","STARD13","","","","",134.6,129.9,119.8,106.2,97.6,128.3,1.1571815718157181,0.2106152535600943,0.16106691958592131,0.7929936471445604,0.3709765510698742,0.4306535406890072,3390]
["High","Q9Y3P9","Rab GTPase-activating protein 1 [OS=Homo sapiens]",26,22,38,20,1069,121.7,5.25,80,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity;other molecular function","RABGAP1","ENSG00000011454","","TBC/RABGAPs","",1398.8,1384,1393.2,1221.1,1181,1205,1.157716725347232,0.21128229224661405,1.074403605759698E-4,3.968832542819877,0.010618915637685723,1.973919829451683,79]
["High","Q9Y3Q3","Transmembrane emp24 domain-containing protein 3 [OS=Homo sapiens]",9,2,7,2,217,24.8,5.6,19.2,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED3","ENSG00000166557","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",429.3,444.1,480.3,420.9,499.5,430.6,1.0019985196151,2.8803770505549547E-3,0.9767378220584497,0.010221994841633508,0.986593650017125,5.861684101322988E-3,7730]
["High","Q9Y3Q4","Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [OS=Homo sapiens]",2,2,2,2,1203,129,8.91,2.14,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","HCN4","ENSG00000138622","Genes targeted by miRNAs in adipocytes","HCN channels","cAMP signaling pathway; Taste transduction",46.7,35.9,45,43.1,39.3,44.6,1.0047244094488188,0.006799832105341037,0.9595414725430338,0.0179362497900527,0.9784641266313189,0.009455092225355666,7657]
["High","Q9Y3R0","Glutamate receptor-interacting protein 1 [OS=Homo sapiens]",4,3,4,3,1128,122.3,6.47,2.15,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","GRIP1","ENSG00000155974","Brain-derived neurotrophic factor (BDNF) signaling pathway; Fragile X syndrome; 7q11.23 copy number variation syndrome; Development of ureteric collection system","Trafficking of GluR2-containing AMPA receptors","",19.1,24.5,11.1,17.5,15.4,18,1.0746561886051083,0.10387517671686154,0.7658238433606848,0.1158711163393687,0.8807707422242196,0.05513712035512431,6789]
["High","Q9Y3R5-1","Protein dopey-2 [OS=Homo sapiens]",3,5,5,5,2298,258.1,6.29,4.3,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","DOP1B","ENSG00000142197","","","",120.7,98.7,120.9,87.1,106.9,88,1.2067375886524823,0.27111198867885256,0.11825718448647335,0.9271724650675426,0.31225975531632866,0.5054839849350248,2957]
["High","Q9Y3S1-1","Serine/threonine-protein kinase WNK2 [OS=Homo sapiens]",12,25,42,17,2297,242.5,6.13,74.88,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","WNK2","ENSG00000165238","","Stimuli-sensing channels","",1786.5,1767.7,1790.1,1733.5,1775,1722.4,1.021678869792961,0.030941805121145468,0.09620556428063556,1.0167998087678904,0.2767770987115706,0.5578698474329732,2714]
["High","Q9Y3S2","zinc finger protein 330 [OS=Homo sapiens]",24,7,19,7,320,36.2,6.16,30.55,"","nucleus;other cell component","other molecular function","ZNF330","ENSG00000109445","","","",645.1,731.2,622.2,686,648.6,631.6,{"$f":"AVERAGE(T7618:V7618)/AVERAGE(W7618:Y7618)","v":1.0164276268945176},{"$f":"LOG(Z7618,2)","v":0.023507494043893594},{"$f":"TTEST(T7618:V7618,W7618:Y7618,2,2)","v":0.7847784988909574},{"$f":"-LOG10(AB7618)","v":0.10525290412572262},{"$f":"AB7618*7808/AF7618","v":0.8901148343028175},{"$f":"-LOG10(AD7618)","v":0.050553961122609875},6884]
["High","Q9Y3T6","R3H and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",10,4,5,4,440,49.1,5.63,11.19,"","","nucleic acid binding activity","R3HCC1","ENSG00000104679","","","",207.3,183.5,190,195.5,242.6,179.7,0.9401100679831662,-0.0890984176318868,0.5741721118501559,0.24095790547190804,0.761143607695419,0.11853339560037424,5890]
["High","Q9Y3T9","Nucleolar complex protein 2 homolog [OS=Homo sapiens]",27,18,61,18,749,84.9,5.62,100.48,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","other molecular function","NOC2L","ENSG00000188976","","Regulation of TP53 Activity through Phosphorylation","",2596.3,2431.8,2833.5,2497.6,2806.9,2703.2,0.9817550607540243,-0.026564965167662533,0.7583607015487049,0.12012418034133505,0.8770967793945027,0.056952483671519956,6751]
["High","Q9Y3U8","60S ribosomal protein L36 [OS=Homo sapiens]",21,2,9,2,105,12.2,11.59,23.05,"protein metabolism;other metabolic processes","cytosol;translational apparatus;nucleus","other molecular function","RPL36","ENSG00000130255","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",473.4,446.2,475.3,454.2,397.3,369.8,1.1421436174568083,0.19174407203644747,0.09496874698730699,1.0224192920170843,0.27392536995821687,0.5623677431289552,2707]
["High","Q9Y3X0","coiled-coil domain-containing protein 9 [OS=Homo sapiens]",11,5,7,5,531,59.7,5.4,15.69,"","","","CCDC9","ENSG00000105321","IL-18 signaling pathway","","",254.2,259.1,245.7,375.9,273.4,202.5,0.8910542380840573,-0.1664148442475089,0.5731787990056492,0.24170988185658504,0.7604723980690075,0.1189165443774031,5885]
["High","Q9Y3Z3","deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [OS=Homo sapiens]",40,24,80,24,626,72.2,7.14,136.63,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMHD1","ENSG00000101347","","Interferon alpha/beta signaling; Nucleotide catabolism","Human immunodeficiency virus 1 infection",2912.6,2905.7,2970.3,2893.3,2852.4,2808.5,1.027401744172453,0.03900042799627607,0.07061933858662861,1.1510763543107667,0.22898496498521434,0.6401930322379183,2408]
["High","Q9Y426","C2 domain-containing protein 2 [OS=Homo sapiens]",10,4,6,4,696,75.5,6.92,13.35,"","other membranes","","C2CD2","ENSG00000157617","","","",125.1,110.3,127.3,135.8,158.7,137.3,0.8399722093561833,-0.2515864980522257,0.06499024932880214,1.1871517969009817,0.21741382466121983,0.6627128439516976,2334]
["Low","Q9Y448","Small kinetochore-associated protein [OS=Homo sapiens]",2,1,1,1,316,35.4,6.3,1.83,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KNSTRN","ENSG00000128944","Leukocyte-intrinsic Hippo pathway functions","","",70,63.4,74.8,120.7,78.4,68.1,0.7791916167664669,-0.3599499391746355,0.29738391897734173,0.5266825196346008,0.529768113021922,0.2759141856299247,4383]
["High","Q9Y450-1","HBS1-like protein [OS=Homo sapiens]",28,15,37,15,684,75.4,6.61,87.73,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol","nucleic acid binding activity;other molecular function","HBS1L","ENSG00000112339","","mRNA decay by 3' to 5' exoribonuclease","mRNA surveillance pathway; Legionellosis",1372.7,1370,1309.3,1412.7,1355.3,1368.1,0.9796668359082228,-0.029636892500267985,0.3583881536608031,0.4456463541571568,0.591730747258099,0.22787586351394776,4729]
["Medium","Q9Y458-1","T-box transcription factor TBX22 [OS=Homo sapiens]",2,1,2,1,520,57.9,7.33,2.14,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TBX22","ENSG00000122145; ENSG00000277800","","","",53.7,43.5,43.6,71.9,45.8,53.6,0.8219497956800934,-0.2828778174467017,0.2948916314671948,0.5303375518265934,0.5274945838478482,0.2777819952095465,4365]
["High","Q9Y462","Zinc finger protein 711 [OS=Homo sapiens]",4,2,2,2,761,86.2,6.87,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF711","ENSG00000147180","","Generic Transcription Pathway","",33.8,32.1,34.3,41.9,37.1,41.2,0.8336106489184691,-0.26255438751597715,0.01523619190882081,1.8171235657815683,0.10107407512665495,0.9953602239663676,1177]
["High","Q9Y467","sal-like protein 2 [OS=Homo sapiens]",24,14,35,13,1007,105.2,6.3,102.72,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SALL2","ENSG00000165821","","","",1377.6,1453,1374.1,1683.9,1577.8,1593,0.8661091313572414,-0.20737927623050167,6.674472125116529E-3,2.1755830763625554,0.06498039694876541,1.1872176399880834,802]
["High","Q9Y467-3","Isoform 2 of Sal-like protein 2 [OS=Homo sapiens]",13,1,3,1,198,20.9,4.77,9.61,"","","","SALL2","","","","",65,67.6,63.9,87,60.7,70,0.902618282039504,-0.14781209504223766,0.4149580265843771,0.38199583038355145,0.6398089003891817,0.19394972273421476,5064]
["High","Q9Y478","5'-AMP-activated protein kinase subunit beta-1 [OS=Homo sapiens]",11,2,2,2,270,30.4,6.4,5.7,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","PRKAB1","ENSG00000111725","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma","Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy",121.8,103,125.7,126,117.5,125.9,0.9488359501894965,-0.0757694220844526,0.4511162304050471,0.3457115474344377,0.6678641499815335,0.17531186823321784,5274]
["High","Q9Y483","Metal-response element-binding transcription factor 2 [OS=Homo sapiens]",9,4,4,4,593,67.1,8.72,8.81,"","","","","","","","",182,167.1,171.2,213,210.3,221.6,0.8067917506590168,-0.3097317622307014,1.7632593752325045E-3,2.7536837983377946,0.03424758507914277,1.4653700467636295,402]
["High","Q9Y484-1","WD repeat domain phosphoinositide-interacting protein 4 [OS=Homo sapiens]",3,1,1,1,360,39.8,7.14,2.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;other cell component","other molecular function","WDR45","ENSCANG00000035794; ENSCSAG00000012964; ENSG00000196998; ENSGGOG00000000589; ENSMFAG00000032970; ENSMLEG00000042347; ENSMMUG00000010620","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway","Macroautophagy","",92.6,86.6,85.2,94.7,82.7,91.3,0.983997022701898,-0.02327414450547438,0.7518259020688062,0.12388271595690772,0.8744609926043853,0.05825955848319278,6713]
["High","Q9Y485","DmX-like protein 1 [OS=Homo sapiens]",5,10,10,9,3027,337.6,6.34,18.22,"other biological processes","other cell component","","DMXL1","ENSG00000172869","","","Lysosome",325.2,322.3,378.3,364.7,410.9,380.2,0.8875237930437793,-0.17214229859828498,0.12899210831133584,0.8894368588610502,0.3272158485038695,0.4851656696978746,3078]
["High","Q9Y487","V-type proton ATPase 116 kDa subunit a isoform 2 [OS=Homo sapiens]",20,13,19,12,856,98,6.61,26.08,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V0A2","ENSG00000185344","","Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; ROS and RNS production in phagocytes","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Human papillomavirus infection; Rheumatoid arthritis",531,527.4,524.7,519.2,554.5,495.3,1.0089866156787763,0.012907037058813534,0.7992198130408648,0.09733375828099908,0.8986619095943364,0.04640366579079914,6944]
["High","Q9Y490","Talin-1 [OS=Homo sapiens]",61,118,456,100,2541,269.6,6.07,1103.31,"cell adhesion;cell organization and biogenesis;signal transduction","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN1","ENSG00000137076","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion","Signaling by BRAF and RAF1 fusions; p130Cas linkage to MAPK signaling for integrins; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Platelet degranulation ; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection",18238.8,17842.2,18123.2,18608.7,18607.5,18838.2,0.9669927784437974,-0.04842297927234399,0.011797184092072274,1.9282216434748825,0.08839962897399263,1.0535495577797527,1042]
["High","Q9Y496","kinesin-like protein KIF3A [OS=Homo sapiens]",11,7,8,7,699,80,6.54,14.44,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3A","ENSG00000131437","Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO","Hedgehog signaling pathway",352.6,292.6,317.2,346.4,326.4,315.2,0.9740890688259111,-0.037874399295963326,0.6866396293276441,0.1632711349305888,0.8332735818760095,0.07921238683790442,6434]
["High","Q9Y4A5","Transformation/transcription domain-associated protein [OS=Homo sapiens]",15,43,73,43,3859,437.3,8.19,147.48,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus","other molecular function","TRRAP","ENSG00000196367","Rett syndrome causing genes","Ub-specific processing proteases; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex","Human T-cell leukemia virus 1 infection",2377.2,2299.3,2514.5,2393.3,2543,2515,0.9650664984633553,-0.051299739348161046,0.32777726730333906,0.484421169823074,0.5601411475387331,0.2517025232201435,4569]
["High","Q9Y4A8","nuclear factor erythroid 2-related factor 3 [OS=Homo sapiens]",2,1,1,1,694,76.1,5.44,3.21,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFE2L3","ENSG00000050344","","","",28.4,23.4,23.2,41.2,41,44.2,0.5933544303797469,-0.7530339627938596,1.0023626283639218E-3,2.998975133751622,0.028051782803819002,1.5520395323665843,279]
["High","Q9Y4B4","Helicase ARIP4 [OS=Homo sapiens]",11,12,19,12,1467,162.7,6.09,39.73,"cell organization and biogenesis","nucleus","nucleic acid binding activity;other molecular function","RAD54L2","ENSG00000164080","","","",793.7,712.9,760.6,869.2,745.7,782,0.9458884392340104,-0.08025805683518583,0.37662169653528443,0.4240946646323312,0.6069478238488134,0.2168486413604799,4845]
["High","Q9Y4B5","Microtubule cross-linking factor 1 [OS=Homo sapiens]",4,6,8,3,1905,209.4,6.43,15.27,"cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MTCL1","ENSG00000168502","","","",68.9,63.7,60.9,73.5,69.3,67.8,0.918803418803419,-0.12217186999394396,0.1206804457145252,0.918363094494718,0.3159868947481599,0.5003309289530583,2982]
["High","Q9Y4B6","DDB1- and CUL4-associated factor 1 [OS=Homo sapiens]",14,17,28,17,1507,168.9,5.06,41.4,"protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","DCAF1","ENSG00000145041","Hippo-Merlin signaling dysregulation","Antigen processing: Ubiquitination & Proteasome degradation","Human immunodeficiency virus 1 infection",784.2,841.9,841.3,900.9,898,923.8,0.9062327836338928,-0.14204641254352962,0.014961841265926612,1.8250149571115701,0.10019044305690822,0.99917370287593,1166]
["High","Q9Y4C1","Lysine-specific demethylase 3A [OS=Homo sapiens]",18,18,28,17,1321,147.2,8.07,66.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3A","ENSG00000115548","Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; HDMs demethylate histones","Thermogenesis",713.4,686.9,748.8,598.2,525.1,631.9,1.2244188696444849,0.2920971836697598,0.022345661885138576,1.6508067768816228,0.12124734398829881,0.9163277661595927,1439]
["High","Q9Y4C2-1","TRPM8 channel-associated factor 1 [OS=Homo sapiens]",17,10,38,10,921,102.1,6.54,88.55,"other biological processes","plasma membrane;other membranes","other molecular function","TCAF1","ENSG00000198420","","","",1182.2,1207.2,1179.4,637.2,642.7,658.5,1.8411060668592656,0.8805727433222287,9.6889697137592664E-7,6.013722401630162,3.7825737762516177E-3,2.4222125926355074,2]
["Medium","Q9Y4C4","Malignant fibrous histiocytoma-amplified sequence 1 [OS=Homo sapiens]",1,1,1,1,1052,116.9,7.88,0,"stress response;developmental processes;other biological processes","other cell component","other molecular function","MFHAS1","ENSG00000147324","","","",19.4,39.8,23.9,15.7,25.4,19.6,1.369028006589786,0.45315196051466256,0.33380299860572354,0.4765097663024586,0.5664711612939555,0.24682219490861945,4601]
["High","Q9Y4C5-1","Carbohydrate sulfotransferase 2 [OS=Homo sapiens]",4,2,2,2,530,57.8,9.98,2.4,"other metabolic processes;stress response;developmental processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","CHST2; HEL-S-75","ENSG00000175040; ENSPTRG00000043559","Metapathway biotransformation Phase I and II","Keratan sulfate biosynthesis","Glycosaminoglycan biosynthesis",133,126.9,132.7,136.4,128.2,139.9,0.9705809641532754,-0.04307952985116916,0.37698618175234555,0.42367456835837136,0.6069088880664565,0.21687650230199962,4850]
["High","Q9Y4C8","Probable RNA-binding protein 19 [OS=Homo sapiens]",28,23,42,23,960,107.3,6.54,86.59,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","RBM19","ENSG00000122965","","","",2026.3,1964.1,2148.8,2064.6,2186.4,2178.4,0.9548635953588204,-0.0666334395973078,0.2223778160965544,0.6529085391555726,0.448547142361637,0.3481919058158922,3871]
["High","Q9Y4D1","Disheveled-associated activator of morphogenesis 1 [OS=Homo sapiens]",9,10,10,10,1078,123.4,7.23,14.3,"cell-cell signaling;cell organization and biogenesis;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","DAAM1","ENSG00000100592","Physico-chemical features and toxicity-associated pathways; Wnt signaling","RHO GTPases Activate Formins; RHOA GTPase cycle; PCP/CE pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle","Wnt signaling pathway",382.2,429.4,397.2,327.9,312.6,333.4,1.241195194578499,0.31173001644012255,0.006819105541787091,2.16627258776903,0.06540979861212974,1.1843571879995958,814]
["High","Q9Y4D8-1","Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",3,8,10,7,3996,439.1,6.19,14.21,"protein metabolism;other metabolic processes;other biological processes","other membranes","other molecular function","HECTD4","","","","",124.3,133.3,132.9,118.8,132,135.7,1.0103492884864165,0.014854134217131804,0.8325598531120297,0.07958453506860831,0.9188165841835658,0.036771174606300756,7075]
["High","Q9Y4E1","WASH complex subunit 2C [OS=Homo sapiens]",28,24,45,6,1318,144.6,4.79,72.31,"","","","","","","","",102,97,98.3,125.7,105.3,112.2,0.8662587412587414,-0.2071300895919011,0.0683835720614315,1.165048217285392,0.22424986587805845,0.6492678080316363,2381]
["High","Q9Y4E5","E3 SUMO-protein ligase ZNF451 [OS=Homo sapiens]",14,13,18,13,1061,121.4,6.77,38.79,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","ZNF451","ENSG00000112200","","","",777.1,766.3,764.8,740.6,751.9,750.1,1.0292517613484349,0.041595917531155054,0.013859748032297396,1.8582446650472673,0.09645001126219079,1.0156977173087745,1122]
["High","Q9Y4E8","ubiquitin carboxyl-terminal hydrolase 15 [OS=Homo sapiens]",31,25,59,23,981,112.3,5.22,110.07,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","USP15","ENSG00000135655","","Ub-specific processing proteases; UCH proteinases; Downregulation of TGF-beta receptor signaling","Mitophagy",2279.1,2394.4,2320.4,2225,2109.2,2134.7,1.0811575383759218,0.11257675736868665,0.022891165599914852,1.640332092833412,0.12216966575812382,0.9130366143000875,1463]
["High","Q9Y4F1","FERM, RhoGEF and pleckstrin domain-containing protein 1 [OS=Homo sapiens]",13,10,15,10,1045,118.6,8.15,31.63,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","FARP1","ENSG00000152767","","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOA GTPase cycle; RHOF GTPase cycle","",642,695.4,701.4,667.1,706.6,707.8,0.9794859476339178,-0.029903300122203894,0.571681124151368,0.24284614714594552,0.7599057230803339,0.11924028467409156,5874]
["High","Q9Y4F5","Centrosomal protein of 170 kDa protein B [OS=Homo sapiens]",8,11,13,9,1589,171.6,6.84,26.46,"","cytoskeleton;other cell component","","CEP170B","ENSG00000099814","","","",442,454.8,419.1,407.6,340.8,384.2,1.161840014126788,0.21641142268689856,0.051133020899577324,1.291298548731291,0.19084446806113756,0.7193204242678921,2092]
["High","Q9Y4G6","Talin-2 [OS=Homo sapiens]",34,72,166,53,2542,271.4,5.57,360.2,"cell adhesion;cell organization and biogenesis","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN2","ENSG00000171914","Focal adhesion","","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection",4023.4,3922.1,3908.7,3531,3380.1,3381.7,1.1516982745219961,0.2037628045699942,1.0857961558488336E-3,2.9642517002531834,0.029033891728998947,1.5370947470429663,292]
["High","Q9Y4G8","rap guanine nucleotide exchange factor 2 [OS=Homo sapiens]",4,4,6,3,1499,167.3,6.67,7.87,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RAPGEF2","ENSG00000109756","MAPK signaling pathway","RAF/MAP kinase cascade","MAPK signaling pathway; Rap1 signaling pathway; Tight junction",30.2,45.1,35.2,27,26.6,31.8,1.2939110070257611,0.37173839465830355,0.1487370602452775,0.8275808064969892,0.3555844967529475,0.4490571822390032,3266]
["High","Q9Y4H2","Insulin receptor substrate 2 [OS=Homo sapiens]",6,7,8,7,1338,137.2,8.65,17,"other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","IRS2","ENSG00000185950","Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Nonalcoholic fatty liver disease; Insulin signaling; FOXA2 pathway; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways","PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF/MAP kinase cascade; Growth hormone receptor signaling; Interleukin-7 signaling; Signaling by Leptin; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); PI3K Cascade; PI3K/AKT activation; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; SOS-mediated signalling; IRS activation; Signal attenuation","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Alzheimer disease; MicroRNAs in cancer",454.5,440,420.7,369.9,342.7,333.3,1.2574815947987383,0.33053728409687894,0.003645274611688396,2.438269749143375,0.0483230970595297,1.3158452392718412,589]
["High","Q9Y4I1-1","Unconventional myosin-Va [OS=Homo sapiens]",10,15,19,11,1855,215.3,8.48,27.22,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5A","ENSG00000197535","Joubert syndrome","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing","Pathogenic Escherichia coli infection",740.9,683.7,786.9,763.3,789.8,742.2,0.9634906112490741,-0.05365748666464931,0.44333962562719714,0.35326344979217617,0.661746472356558,0.17930836516097678,5231]
["High","Q9Y4I5","Tesmin [OS=Homo sapiens]",10,3,3,3,508,55,5.71,5.92,"other biological processes","nucleus;other cell component","other molecular function","TESMIN","ENSG00000132749","","","",49.8,45.3,43.9,72,52.6,59.8,0.7537960954446856,-0.4077537728184679,0.06331902245546572,1.1984657985708023,0.21458113165463386,0.6684084686633414,2304]
["High","Q9Y4K0","Lysyl oxidase homolog 2 [OS=Homo sapiens]",8,5,7,5,774,86.7,6.38,16.64,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","LOXL2","ENSG00000134013","Canonical and non-canonical TGF-B signaling","Crosslinking of collagen fibrils; Elastic fibre formation","",261.1,260,282.6,255.5,238.1,227.5,1.1145472195257247,0.15645773991080972,0.06636037967761124,1.1780911378462942,0.22001776837485715,0.6575422446525738,2355]
["High","Q9Y4K3","TNF receptor-associated factor 6 [OS=Homo sapiens]",19,6,9,6,522,59.5,6.44,15.13,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TRAF6","ENSG00000175104","IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; T-cell receptor (TCR) signaling pathway; Toll-like receptor signaling pathway","Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; TRAF6 mediated NF-kB activation; Ovarian tumor domain proteases; TRAF6 mediated IRF7 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PIP3 activates AKT signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","MAPK signaling pathway; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; Autophagy; Endocytosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; Neurotrophin signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",119.3,116.8,106.1,109.7,98,103.3,1.10032154340836,0.1379251794714483,0.11997033192410467,0.9209261395746925,0.31465513996083616,0.5021651695627818,2977]
["High","Q9Y4K4","mitogen-activated protein kinase kinase kinase kinase 5 [OS=Homo sapiens]",12,7,15,7,846,95,7.64,13.31,"","","","","","","","",400.1,398.9,311.2,404.2,376.7,426.2,0.9197249606494906,-0.12072560027355322,0.37962173592579507,0.4206489292205602,0.6092675260243798,0.2151919691662955,4865]
["High","Q9Y4L1","Hypoxia up-regulated protein 1 [OS=Homo sapiens]",61,48,364,48,999,111.3,5.22,807.97,"stress response;transport;other biological processes","non-structural extracellular;ER/Golgi;other cell component","other molecular function","HYOU1","ENSG00000149428; ENSG00000280682","VEGFA-VEGFR2 signaling pathway","XBP1(S) activates chaperone genes; Scavenging by Class F Receptors","Protein processing in endoplasmic reticulum",13722.2,12798,13441.4,13883.8,12869.7,13655.9,0.9889184199715907,-0.01607658295946717,0.7350492744038253,0.1336835467873728,0.8643470985760644,0.06331182149675489,6640]
["High","Q9Y4L5","E3 ubiquitin-protein ligase RNF115 [OS=Homo sapiens]",11,2,2,2,304,33.7,5.69,6.65,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","RNF115","ENSG00000265491","","Antigen processing: Ubiquitination & Proteasome degradation","",62.1,63.3,62.8,66.8,61.9,69.2,0.9509853461344114,-0.07250498431897513,0.21151568454691275,0.6746574228061291,0.4358708009876735,0.36064222342248675,3789]
["High","Q9Y4P1-1","Cysteine protease ATG4B [OS=Homo sapiens]",27,7,28,7,393,44.3,5.07,63.67,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol","other molecular function","ATG4B","ENSG00000168397","","Macroautophagy","Autophagy; Autophagy",483.4,506.9,504.8,531.7,520.4,508.7,0.957906201947719,-0.06204370052299475,0.09421363874429824,1.0258862224445668,0.2731600784684295,0.5635827711974419,2693]
["High","Q9Y4P3","Transducin beta-like protein 2 [OS=Homo sapiens]",25,12,21,12,447,49.8,9.44,35.73,"stress response;signal transduction","other membranes;ER/Golgi","other molecular function","TBL2","ENSG00000106638","7q11.23 copy number variation syndrome","","",888.2,891.5,924.8,924.1,965.3,907.2,0.9670671529714652,-0.048312021219240484,0.21472329427359577,0.6681208385366715,0.4393499689958689,0.3571893999100935,3816]
["High","Q9Y4P8-1","WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",23,6,9,1,454,49.4,6.46,22.96,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","WIPI2","ENSG00000157954","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease","Macroautophagy","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis",389.1,344.6,429.8,308.3,393.9,358.8,1.096606974552309,0.13304655449058367,0.38381061791631155,0.4158830149088375,0.6127158668351177,0.2127408730714844,4891]
["High","Q9Y4P8-6","Isoform 6 of WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",24,6,9,1,443,48.2,6.3,21.67,"","","","WIPI2","","","","",36.6,17.1,21.5,23.6,25,23.5,1.042995839112344,0.060733402436814854,0.8700143778145323,0.0604735701929709,0.9342693249863662,0.029527910178200757,7271]
["High","Q9Y4R8","telomere length regulation protein TEL2 homolog [OS=Homo sapiens]",23,15,27,15,837,91.7,5.76,55.26,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TELO2","ENSG00000100726","Fragile X syndrome; Malignant pleural mesothelioma","","Fanconi anemia pathway; mTOR signaling pathway",794.4,693.5,686.1,716.4,715.8,763.1,0.9902974536509818,-0.014066165198632075,0.8618983597685071,0.06454394576961088,0.9314466980031146,0.03084199253956099,7225]
["Low","Q9Y4U1","Methylmalonic aciduria and homocystinuria type C protein [OS=Homo sapiens]",3,1,1,1,282,31.7,7.81,0,"other metabolic processes","cytosol;other cell component","other molecular function","MMACHC","ENSG00000132763","","Cobalamin (Cbl, vitamin B12) transport and metabolism; Defective MMADHC causes MMAHCD; Defective MMACHC causes MAHCC","Vitamin digestion and absorption",19.8,21.1,26.7,25.4,32.7,26.6,0.7981109799291618,-0.3253387230500142,0.13947987833867714,0.8554884401092545,0.34182639361845296,0.46619440691573183,3186]
["High","Q9Y4W2","Ribosomal biogenesis protein LAS1L [OS=Homo sapiens]",44,25,55,25,734,83,4.73,103.69,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LAS1L","ENSG00000001497","","Major pathway of rRNA processing in the nucleolus and cytosol","",2233,2347.6,2252.9,2581.5,2608.2,2526.7,0.8855813591830388,-0.17530324008635337,2.327983753176483E-3,2.633020054920097,0.03968754835109603,1.401345728265331,458]
["High","Q9Y4W6","AFG3-like protein 2 [OS=Homo sapiens]",29,22,59,21,797,88.5,8.66,131.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","AFG3L2","ENSG00000141385","Ciliary landscape","Processing of SMDT1","Spinocerebellar ataxia",3171.5,3096.7,3123.3,2966.1,3029.5,3013.7,1.0424228297425993,0.05994058533081693,0.01178446247593371,1.9286902221392186,0.08838912873399654,1.0536011469911193,1041]
["High","Q9Y4X0","AMME syndrome candidate gene 1 protein [OS=Homo sapiens]",10,3,4,2,333,35.4,8.63,6.99,"","mitochondrion;nucleus","","AMMECR1","ENSG00000101935","","","",150.2,129.4,161.2,132,161.2,138.8,1.0203703703703704,0.029092911520326722,0.8304406248400377,0.08069141345479178,0.91738545539771,0.03744814963088283,7068]
["High","Q9Y4X5","E3 ubiquitin-protein ligase ARIH1 [OS=Homo sapiens]",37,15,42,15,557,64.1,5.08,85.92,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ARIH1","ENSG00000166233","","ISG15 antiviral mechanism","",1459.7,1457.5,1474.7,1428.7,1398.7,1422.7,1.033363920848921,0.04734841910475499,0.011312445277852233,1.9464435086118712,0.0865956595386963,1.0625038757151535,1020]
["High","Q9Y4Y9","U6 snRNA-associated Sm-like protein LSm5 [OS=Homo sapiens]",32,2,2,2,91,9.9,4.54,0,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM5","ENSG00000106355","","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",124.5,114.7,111.5,124.7,116.7,117.9,0.9760645699972168,-0.03495150474935165,0.5698622553707039,0.24423010741831092,0.7586503819155083,0.11995831921122356,5865]
["Low","Q9Y4Z0","U6 snRNA-associated Sm-like protein LSm4 [OS=Homo sapiens]",5,1,1,1,139,15.3,9.99,2.19,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM4","ENSG00000130520","Ciliary landscape","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",111.3,119.8,115.5,149.4,113.4,115.5,0.9162040708432462,-0.12625912188920624,0.42548471969703666,0.37111603198460696,0.6492446143041748,0.1875916442980888,5117]
["High","Q9Y508-1","E3 ubiquitin-protein ligase RNF114 [OS=Homo sapiens]",27,5,13,5,228,25.7,7.25,31.58,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","RNF114","ENSG00000124226; ENSPPAG00000043607; ENSPTRG00000013613","","Antigen processing: Ubiquitination & Proteasome degradation","",458.7,443.1,436.7,498.8,443.6,454.7,0.958055973087109,-0.06181814901334411,0.3407404276018937,0.46757633592783066,0.5727666864834415,0.24202224959885585,4645]
["High","Q9Y512","sorting and assembly machinery component 50 homolog [OS=Homo sapiens]",33,13,45,13,469,51.9,6.9,78.11,"cell organization and biogenesis;transport","other membranes;mitochondrion","","SAMM50","ENSG00000100347","","RAC2 GTPase cycle; Mitochondrial protein import; Cristae formation","",1264.7,1251.5,1376,1199.6,1360,1327.4,1.0013377926421403,1.928736972949078E-3,0.979331271294275,0.009070377696800483,0.9881905616781725,5.159298423391228E-3,7738]
["High","Q9Y520","Protein Prrc2c [OS=Homo sapiens]",27,63,184,62,2896,316.7,9.13,350.47,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;other cell component","other molecular function","PRRC2C","ENSG00000117523","VEGFA-VEGFR2 signaling pathway","","",8892.3,8359.5,8662.7,10781.8,8622.3,9147.1,0.907650116282328,-0.13979182466530196,0.25880016459551064,0.5870354517942983,0.4878589293002769,0.31170574169309667,4142]
["High","Q9Y530","O-acetyl-ADP-ribose deacetylase 1 [OS=Homo sapiens]",14,2,3,2,152,17,8.31,5.34,"protein metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","OARD1","ENSG00000124596","","","",118.6,132.9,117.5,140.1,130.6,140.8,0.896719319562576,-0.15727161436122952,0.07597151397713191,1.1193492187929963,0.2402533742946318,0.6193305040662931,2469]
["High","Q9Y535","DNA-directed RNA polymerase III subunit RPC8 [OS=Homo sapiens]",27,3,4,3,204,22.9,4.58,7.21,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR3H","ENSG00000100413","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",104.5,91,110.9,114.3,113.2,109.1,0.9102792632204396,-0.13561887940499207,0.1728416809249073,0.762351518727031,0.38503504840561376,0.414499736371073,3505]
["High","Q9Y546","Leucine-rich repeat-containing protein 42 [OS=Homo sapiens]",7,3,3,3,428,48.5,7.46,8.42,"","","","LRRC42","ENSG00000116212","","","",169,185.6,186.8,273.3,275.9,285.6,{"$f":"AVERAGE(T7682:V7682)/AVERAGE(W7682:Y7682)","v":0.648538572113081},{"$f":"LOG(Z7682,2)","v":-0.6247357129448713},{"$f":"TTEST(T7682:V7682,W7682:Y7682,2,2)","v":1.402415301518342E-4},{"$f":"-LOG10(AB7682)","v":3.8531233583740967},{"$f":"AB7682*7808/AF7682","v":0.011648998589633206},{"$f":"-LOG10(AD7682)","v":1.9337114073151598},94]
["High","Q9Y547","Intraflagellar transport protein 25 homolog [OS=Homo sapiens]",42,4,11,4,144,16.3,5.03,29.53,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","HSPB11","ENSG00000081870","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis","Intraflagellar transport","",195.1,215.3,224.8,219.1,238.6,225.9,0.9291983616149796,-0.10594148453318146,0.19773067326556,0.7039259548811512,0.4169271123028605,0.37993986227195836,3703]
["High","Q9Y548","Protein YIPF1 [OS=Homo sapiens]",6,2,4,2,306,34.3,5.31,12.28,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","YIPF1","ENSG00000058799","","","",245.4,255.4,258.6,247.6,253.3,268,0.9876446872155027,-0.017935980393644496,0.685289337008969,0.1641260256817926,0.83215227735086,0.0797971939473793,6430]
["High","Q9Y570","Protein phosphatase methylesterase 1 [OS=Homo sapiens]",41,14,44,14,386,42.3,5.97,87.1,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","nucleus","enzyme regulator activity;other molecular function","PPME1","ENSG00000214517","","Cyclin A/B1/B2 associated events during G2/M transition","",1696.2,1693.1,1732.4,1649.5,1713.7,1695.1,1.012533855247811,0.017970146991393623,0.4076798788792806,0.3896807227085977,0.6334655710028702,0.19827698414248884,5025]
["High","Q9Y573-1","actin-binding protein IPP [OS=Homo sapiens]",3,2,2,2,584,65.2,5.73,2.39,"","cytoskeleton;other cell component","cytoskeletal activity","IPP","ENSG00000197429; ENSPPAG00000037424","","","",109.8,99.1,108.4,116,122.5,120.1,0.8848298940323478,-0.17652796695073747,0.023388817576263897,1.6309917334317263,0.12347524518963388,0.9084201027699834,1479]
["High","Q9Y575","Ankyrin repeat and SOCS box protein 3 [OS=Homo sapiens]",2,1,3,1,518,57.7,6.27,5.21,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","","ASB3","ENSG00000115239","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",32.8,27.1,31.8,27.5,27.2,38.4,0.9849624060150376,-0.021859433963739322,0.9144891028476767,0.038821465257350314,0.9557396486460527,0.019660397007855997,7471]
["High","Q9Y576","Ankyrin repeat and SOCS box protein 1 [OS=Homo sapiens]",3,1,1,1,335,37,8.21,2.49,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","","ASB1","ENSG00000065802","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",47.1,52.1,72.3,47.8,74.7,63.4,0.9225389994620763,-0.11631819385930704,0.6840669129432111,0.1649014150917404,0.8315731677192265,0.08009953244720577,6423]
["High","Q9Y580","RNA-binding protein 7 [OS=Homo sapiens]",6,2,4,2,266,30.5,9.57,11.13,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RBM7","ENSG00000076053","","","",405.7,348.1,375.6,558.4,461.2,491.5,0.7474025544305474,-0.42004260039805286,0.01855222078667322,1.7316040958780847,0.11237838627024399,0.9493172085728525,1289]
["High","Q9Y587-1","AP-4 complex subunit sigma-1 [OS=Homo sapiens]",7,1,3,1,144,17,5.19,5.1,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","AP4S1","ENSCANG00000008358; ENSCATG00000035780; ENSG00000100478; ENSGGOG00000003198; ENSMMUG00000003123; ENSPANG00000017427; ENSPCOG00000016646; ENSPPAG00000041450; ENSPTRG00000006239; ENSRROG00000019504","","Lysosome Vesicle Biogenesis","Lysosome",68,66.6,69.2,67.1,83.9,66.4,0.937442502299908,-0.09319788886149535,0.4759418166075035,0.3224461360836549,0.6880491953474148,0.162380508706213,5401]
["High","Q9Y592","Centrosomal protein of 83 kDa [OS=Homo sapiens]",2,2,4,2,693,82,6.28,6.88,"","","","","","","","",38.7,55.4,56,52.9,53.6,45.4,0.988150098749177,-0.017197892881395095,0.9281070882849952,0.03240191045352333,0.9642927671762133,0.015791090717814888,7515]
["High","Q9Y597","BTB/POZ domain-containing protein KCTD3 [OS=Homo sapiens]",9,6,8,6,815,88.9,7.03,12.51,"cell organization and biogenesis","plasma membrane;other membranes","","KCTD3","ENSG00000136636","","CDC42 GTPase cycle","",266.4,253.3,251.4,301.3,265.5,252.1,0.941629014531689,-0.08676931988476297,0.35994994389450546,0.4437578897935322,0.5934309885828333,0.22662977884976024,4736]
["High","Q9Y5A7","NEDD8 ultimate buster 1 [OS=Homo sapiens]",24,16,25,16,615,70.5,5.96,60.75,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","","NUB1","ENSG00000013374","","","",1460,1344.7,1470.3,1196,1184,1180.8,1.2005729049651763,0.26372301409571564,0.004194528121110213,2.3773168896445664,0.05125332640004467,1.2902779431443314,639]
["High","Q9Y5A9-1","YTH domain-containing family protein 2 [OS=Homo sapiens]",18,10,41,7,579,62.3,8.79,79.38,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity","YTHDF2","ENSCSAG00000001018; ENSG00000198492; ENSMFAG00000026128; ENSMMUG00000011391; ENSMNEG00000041161; ENSNLEG00000009856; ENSPTRG00000000439; ENSRBIG00000043898; ENSRROG00000038863","","","",1678.2,1641.9,1765.8,2101.9,2112.3,2144.3,0.7998584571832978,-0.3221833713705357,4.0251548199529263E-4,3.395217410660548,0.01806230392769681,1.7432268542845124,174]
["High","Q9Y5B0","RNA polymerase II subunit A C-terminal domain phosphatase [OS=Homo sapiens]",25,19,43,19,961,104.3,5.27,78.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CTDP1","ENSG00000060069","","TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1697.2,1830.2,1679.6,1681.5,1655.2,1709.4,1.0318860109787755,0.04528360983238637,0.3442373758306212,0.463141977600102,0.5770299335520589,0.2388016571401285,4658]
["High","Q9Y5B6","PAX3- and PAX7-binding protein 1 [OS=Homo sapiens]",15,12,23,12,917,104.7,5.68,46.07,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity","PAXBP1","ENSG00000159086; ENSG00000263141","","","",1078.5,1036.3,1118.7,1193.4,1133.5,1173.7,0.9236987944923726,-0.11450560962531936,0.03966229801288593,1.40162212660568,0.16739633669438558,0.7762540503500586,1850]
["High","Q9Y5B8","Nucleoside diphosphate kinase 7 [OS=Homo sapiens]",15,4,8,4,376,42.5,6.47,11.18,"other metabolic processes","cytosol;cytoskeleton","kinase activity;other molecular function","NME7","ENSG00000143156","Pyrimidine metabolism; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",209.7,200.7,218.4,210.4,220.5,224.9,0.958828911253431,-0.06065468413445433,0.24874676723056585,0.6042425547352004,0.47837801934390595,0.3202287836537591,4060]
["High","Q9Y5B9","FACT complex subunit SPT16 [OS=Homo sapiens]",44,50,246,50,1047,119.8,5.66,516.81,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","SUPT16H","ENSG00000092201","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation","",11948.9,11411.8,12785.9,11567.9,12787.2,12232.8,0.987938635450518,-0.017506661458625533,0.7962263957326245,0.09896342919978733,0.8963286761649845,0.04753270900930582,6936]
["Medium","Q9Y5E1","Protocadherin beta-9 [OS=Homo sapiens]",1,1,1,1,797,87,5.02,2.2,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;other cell component","other molecular function","PCDHB9","ENSG00000177839","","","",71.1,79.2,91.3,79.9,97.1,85.3,0.9210827296988182,-0.1185973529399052,0.42422649847687643,0.3724022076184621,0.6477044388164745,0.1886231266501434,5114]
["Low","Q9Y5F9-1","Protocadherin gamma-B6 [OS=Homo sapiens]",1,1,1,1,930,101,5.26,0,"cell adhesion","plasma membrane;other membranes","other molecular function","PCDHGB6","ENSG00000253305","","","",88.7,97.5,83.1,91.1,89.9,101.3,0.9539496989018772,-0.06801489894802146,0.47749857789036665,0.32102791751538906,0.6891513671290171,0.16168537796332308,5410]
["High","Q9Y5J1","U3 small nucleolar RNA-associated protein 18 homolog [OS=Homo sapiens]",25,11,31,11,556,62,8.76,68.25,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","UTP18","ENSG00000011260","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1379.6,1356.1,1338.1,1768.2,1663.6,1761.5,0.7844337896905627,-0.35027641355277256,4.8251269050524607E-4,3.3164912598457374,0.019221730038086537,1.7162075265435779,196]
["High","Q9Y5K3","Choline-phosphate cytidylyltransferase B [OS=Homo sapiens]",26,8,15,5,369,41.9,6.4,29.65,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PCYT1B","ENSG00000102230","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways","Synthesis of PC","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer",217.5,219.8,198.6,263.8,235.4,233.1,0.8683599617643042,-0.20363488700861143,0.05459214644739715,1.2628698298205425,0.19789019473596886,0.7035757241238698,2154]
["High","Q9Y5K5-1","Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",58,14,68,1,329,37.6,5.33,154.39,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UCHL5","ENSCANG00000036448; ENSCATG00000035323; ENSG00000116750; ENSGGOG00000004347; ENSMFAG00000038349; ENSMLEG00000030039; ENSMNEG00000039813; ENSPPAG00000029294; ENSPTRG00000001793","TGF-beta signaling pathway","UCH proteinases; Downregulation of TGF-beta receptor signaling","",27,29.4,30.4,27.8,24.5,24.5,1.1302083333333335,0.17658873172332332,0.08928536179203292,1.049219737237446,0.26396823357523397,0.5784483337857349,2641]
["High","Q9Y5K5-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",58,14,68,1,328,37.5,5.4,158.34,"","","","UCHL5","","","","",2727.8,2741.5,2924.7,2561.5,2820.3,2630,1.047704635662398,0.06723205587869033,0.2721087817038796,0.5652574421085397,0.5027509151783938,0.2986471301661988,4226]
["High","Q9Y5K6","CD2-associated protein [OS=Homo sapiens]",40,21,42,21,639,71.4,6.4,76.66,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CD2AP","ENSG00000198087","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis","Nephrin family interactions","Bacterial invasion of epithelial cells",1962.9,1975.4,2004.8,2280.5,2116.2,2175.8,0.9042373526055535,-0.14522658056406956,0.013372843859731509,1.8737762261520359,0.09475060331831545,1.0234180160091666,1102]
["High","Q9Y5K8","V-type proton ATPase subunit D [OS=Homo sapiens]",47,12,31,12,247,28.2,9.36,54.53,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol","transporter activity","ATP6V1D","ENSG00000100554","Proximal tubule transport","Amino acids regulate mTORC1; Neutrophil degranulation; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",792,731.7,840.7,727.5,756.9,763.2,1.0519665420893396,0.0730888202866892,0.30838272925029814,0.5109099522855505,0.5421869736515036,0.2658509208005911,4441]
["High","Q9Y5L0-2","transportin-3 [OS=Homo sapiens]",34,23,66,23,923,104.1,5.57,160,"transport","other membranes;nucleus;other cell component","other molecular function","TNPO3","ENSCANG00000033070; ENSCATG00000030018; ENSG00000064419; ENSGGOG00000008339; ENSMLEG00000037881; ENSMMUG00000004311; ENSMNEG00000045277; ENSPPAG00000034975; ENSPPYG00000017990; ENSPTRG00000019676","","","Nucleocytoplasmic transport",2393,2507.9,2504.1,2543.6,2540.7,2587.5,0.9652232852785527,-0.051065374991923325,0.09370031713233724,1.0282589392233101,0.2724812201747818,0.5646634246002491,2685]
["High","Q9Y5M8","signal recognition particle receptor subunit beta [OS=Homo sapiens]",30,7,22,7,271,29.7,9.04,48.58,"transport","other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SRPRB","ENSG00000144867","","SRP-dependent cotranslational protein targeting to membrane; XBP1(S) activates chaperone genes","Protein export",984.9,970.6,1000.3,908.9,1032.3,994.4,1.006881046464096,0.009893252547063636,0.8661923353349088,0.06238566352522764,0.9332454469842649,0.030004120184870486,7247]
["Low","Q9Y5N1","histamine H3 receptor [OS=Homo sapiens]",2,1,1,1,445,48.6,9.29,2.08,"cell-cell signaling;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","HRH3","ENSG00000101180","GPCRs, class A rhodopsin-like; Monoamine transport","Histamine receptors","Neuroactive ligand-receptor interaction",97.6,99.7,89.8,90.6,84.3,108.4,1.0134133427462055,0.01922272882908335,0.8791683365250789,0.05592796153095003,0.9386772010922763,0.02748373029656209,7313]
["High","Q9Y5N5","HemK methyltransferase family member 2 [OS=Homo sapiens]",24,5,9,5,214,22.9,5.11,15.88,"protein metabolism;DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","N6AMT1","ENSG00000156239","","Eukaryotic Translation Termination; Methylation","",431,462.7,425.3,427.1,470.6,431,0.9926996312184841,-0.010570838467565574,0.8670697020507039,0.06194598902985282,0.933289251945395,0.029983735615632966,7254]
["High","Q9Y5N6","Origin recognition complex subunit 6 [OS=Homo sapiens]",41,8,12,8,252,28.1,8.66,17.75,"DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC6","ENSG00000091651","Cell cycle; G1 to S cell cycle control; DNA replication","Assembly of the ORC complex at the origin of replication; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDT1 association with the CDC6:ORC:origin complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle",567.8,607.7,609.7,528.6,532.4,510.3,1.1361293196716096,0.18412705863699502,9.492795452223696E-3,2.0226058770669013,0.07843359459361124,1.105497880917529,945]
["High","Q9Y5P4-1","Collagen type IV alpha-3-binding protein [OS=Homo sapiens]",24,14,39,14,624,70.8,5.48,67.26,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus","transporter activity;kinase activity;other molecular function","CERT1","ENSG00000113163; ENSPTRG00000016996","Sphingolipid pathway","","",1334.3,1348.5,1319.3,1320.5,1208.4,1291.2,1.047642731865658,0.0671468114920278,0.15448869140112306,0.81110330550671,0.3624542375180195,0.4407468184667609,3328]
["High","Q9Y5P6","Mannose-1-phosphate guanyltransferase beta [OS=Homo sapiens]",20,5,17,5,360,39.8,6.61,37.01,"other metabolic processes","other cell component","other molecular function","GMPPB","ENSG00000173540","","Synthesis of GDP-mannose","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",359.8,386,356.6,353.3,330.4,344.5,1.0721649484536082,0.10052687595396444,0.09696861252312591,1.0133688184546201,0.2779482109326605,0.5560361170367322,2724]
["High","Q9Y5Q0","fatty acid desaturase 3 [OS=Homo sapiens]",16,5,7,4,445,51.1,7.77,15.7,"other metabolic processes","other membranes;ER/Golgi","other molecular function","FADS3","ENSG00000221968","","","",111.1,122.6,119.5,146.8,142.1,137.4,0.8285245132535773,-0.2713837123154704,5.1031834326383555E-3,2.2921588207818435,0.056358778277284693,1.2490384299201078,707]
["High","Q9Y5Q8-1","general transcription factor 3C polypeptide 5 [OS=Homo sapiens]",30,13,22,13,519,59.5,6.9,44.41,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity","GTF3C5","ENSG00000148308","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1023,1002.6,952.7,1020.8,1073.9,1013,0.9583614892042349,-0.06135815884993135,0.20242234434418677,0.6937415496890861,0.4229364904039096,0.3737248428800883,3737]
["High","Q9Y5Q9","General transcription factor 3C polypeptide 3 [OS=Homo sapiens]",24,14,47,14,886,101.2,5.07,80.98,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","nucleic acid binding activity","GTF3C3","ENSG00000119041","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1369,1582.2,1358.3,1504,1574.9,1528.6,0.9353228431904504,-0.09646367226439546,0.260323673357165,0.5844863361516417,0.4899029263853324,0.3098899663219794,4149]
["Medium","Q9Y5R2","Matrix metalloproteinase-24 [OS=Homo sapiens]",2,1,1,1,645,73.2,9.23,0,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","MMP24","ENSG00000125966","Matrix metalloproteinases","Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action",28.6,21.5,42.4,29,51.9,42,0.7526444263628966,-0.40995964496898724,0.32478439346300814,0.4884048476443437,0.5574668155988498,0.25378097981566344,4549]
["High","Q9Y5S2","Serine/threonine-protein kinase MRCK beta [OS=Homo sapiens]",16,25,42,23,1711,194.2,6.37,97.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPB","ENSG00000198752","VEGFA-VEGFR2 signaling pathway","CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle","",1938.1,1764.4,1980.8,1840.5,1934.7,1872.1,1.0063747277460027,0.00916759858052837,0.8752566804183253,0.057864565786873295,0.9366782018511902,0.028409586448597653,7296]
["High","Q9Y5S9","RNA-binding protein 8A [OS=Homo sapiens]",48,8,62,2,174,19.9,5.72,123.74,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","RBM8A","ENSG00000265241","","mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",1661.2,1962.6,1776.3,2680.6,1785.4,1554.8,0.8969073877225618,-0.15696907091486692,0.5906880000880244,0.2286418518076843,0.7720274363386833,0.11236726541715837,5974]
["High","Q9Y5S9-2","Isoform 2 of RNA-binding protein 8A [OS=Homo sapiens]",47,7,53,1,173,19.7,5.92,108.93,"","","","RBM8A","","","","",147.3,132.3,138.1,202.2,142.5,124.9,0.8894804088586031,-0.16896526494725933,0.5074826213802366,0.2945788254697149,0.7116422966481479,0.14773824741358518,5568]
["High","Q9Y5T5-1","ubiquitin carboxyl-terminal hydrolase 16 [OS=Homo sapiens]",12,6,11,6,823,93.5,6.93,26.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","USP16","ENSG00000156256","","Ub-specific processing proteases","",194.2,204.6,180.4,199.1,200.8,192.6,0.9775527426160336,-0.03275355158977861,0.58338318531581,0.2340460925776679,0.7678786093974789,0.1147074302753769,5932]
["High","Q9Y5U2-1","Protein TSSC4 [OS=Homo sapiens]",7,3,5,3,329,34.3,5.19,2.98,"","","","TSSC4","ENSG00000184281","","","",52.2,48.7,58.4,59.9,57.3,52.9,0.9365079365079366,-0.09463687413807505,0.3612245658334802,0.44222272224796055,0.5945281218439742,0.22582759794553134,4744]
["High","Q9Y5U9","immediate early response 3-interacting protein 1 [OS=Homo sapiens]",24,1,4,1,82,9,8.22,14.62,"transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","","IER3IP1","ENSG00000134049","","","",185.5,190.4,193.3,186.7,197.1,190.4,0.9912922326715432,-0.01261766868069907,0.6836476016634138,0.16516770543051548,0.8314517871943823,0.0801629288407334,6420]
["High","Q9Y5V3","Melanoma-associated antigen D1 [OS=Homo sapiens]",15,10,29,7,778,86.1,5.83,61.46,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","MAGED1","ENSG00000179222","","NRAGE signals death through JNK; Caspase activation via Dependence Receptors in the absence of ligand","Neurotrophin signaling pathway",729.7,656.3,736.9,725.7,748.1,750.2,0.9545413669064747,-0.06712037390808283,0.2787951774747553,0.5547147428201424,0.509677533533807,0.2927045095883311,4271]
["High","Q9Y5W7","Sorting nexin-14 [OS=Homo sapiens]",3,4,4,4,946,110.1,6.7,1.82,"cell organization and biogenesis;other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX14","ENSG00000135317","","","",123.7,128.6,128.5,128.2,137.6,114.3,1.0018416206261511,2.6544534459780195E-3,0.9748560270745481,0.01105951893121292,0.9859683755696983,0.006137014608313713,7720]
["High","Q9Y5W8","Sorting nexin-13 [OS=Homo sapiens]",3,3,3,3,968,112.1,6.58,7.79,"transport;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","SNX13","ENSG00000071189","","","",48.2,51,47.8,49.9,48.3,51.4,0.982620320855615,-0.025294020163909862,0.5549961682021776,0.2557100153176747,0.7498546602046379,0.12502290512542238,5779]
["High","Q9Y5X1","Sorting nexin-9 [OS=Homo sapiens]",29,10,25,10,595,66.6,5.58,34.17,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","SNX9","ENSG00000130340","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","Salmonella infection",547.5,486.9,539.5,604.6,594.2,658.8,0.8472760551248922,-0.23909599726307945,0.026656845262880553,1.5741912489953713,0.13299466313902325,0.8761657862192032,1565]
["High","Q9Y5X2","Sorting nexin-8 [OS=Homo sapiens]",13,6,12,6,465,52.5,7.39,32.15,"transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX8","ENSG00000106266","","","",326.3,308.4,353.1,383,411.7,396.1,0.8295263688276788,-0.269640252859592,0.011777217301397547,1.92895731170587,0.08850482453254288,1.053033054604412,1039]
["High","Q9Y5X3","sorting nexin-5 [OS=Homo sapiens]",38,14,50,13,404,46.8,6.76,106.93,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","SNX5","ENSG00000089006","","Golgi Associated Vesicle Biogenesis","Endocytosis",1872.4,1862.6,1890.8,1809.2,1862.5,1835.6,1.0215168957565415,0.03071306625674008,0.08653719773701138,1.0627971723110554,0.2592795241483441,0.5862317790289859,2606]
["High","Q9Y5Y0","Feline leukemia virus subgroup C receptor-related protein 1 [OS=Homo sapiens]",17,6,22,6,555,59.8,5.97,57.32,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion","transporter activity;other molecular function","FLVCR1","ENSG00000162769","","","",690.8,685.9,631.8,687.3,662.2,697.7,0.9810961313012895,-0.027533591106617433,0.5832133291150936,0.23417255894422556,0.7677844669921853,0.11476067831892489,5931]
["High","Q9Y5Y2","Cytosolic Fe-S cluster assembly factor NUBP2 [OS=Homo sapiens]",24,5,9,5,271,28.8,5.83,21.95,"cell organization and biogenesis;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NUBP2","ENSG00000095906","","Cytosolic iron-sulfur cluster assembly","",356.3,357.9,382.3,325.1,319.8,366.9,1.0837121960861829,0.11598166775368488,0.17420562803866682,0.7589378184061176,0.38674937268294296,0.4125703820644248,3517]
["High","Q9Y5Z4-1","Heme-binding protein 2 [OS=Homo sapiens]",10,2,2,2,205,22.9,4.63,3.08,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","HEBP2","ENSG00000051620","","Neutrophil degranulation","",110.7,128.3,119.5,107.3,117.3,112.7,1.0628520604802847,0.08794080057114063,0.29323644777839025,0.53278205011121,0.5256175813254524,0.279330116536312,4356]
["Medium","Q9Y5Z6","Beta-1,3-galactosyltransferase 1 [OS=Homo sapiens]",3,1,1,1,326,38,9.29,2.12,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B3GALT1","ENSG00000172318","Ganglio sphingolipid metabolism; Metabolism of spingolipids in ER and Golgi apparatus","Lewis blood group biosynthesis","Glycosphingolipid biosynthesis; Metabolic pathways",25.9,33.5,31.9,18.2,27.2,22,1.3545994065281899,0.4378662688023635,0.08431889944971323,1.074075070609183,0.25517905693928716,0.5931549719137779,2580]
["High","Q9Y5Z9-1","UbiA prenyltransferase domain-containing protein 1 [OS=Homo sapiens]",6,1,1,1,338,36.8,8.15,3.75,"other metabolic processes;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","UBIAD1","ENSG00000120942; ENSGGOG00000001270","7q11.23 copy number variation syndrome","Metabolism of vitamin K","",27.9,31.2,35.9,27.2,29.2,24.8,1.1699507389162562,0.22644778603313406,0.15721485082816267,0.8035064320364929,0.366100076130717,0.4364001808066775,3353]
["High","Q9Y605","MORF4 family-associated protein 1 [OS=Homo sapiens]",19,1,2,1,127,14.6,4.7,9.33,"","nucleus;other cell component","","MRFAP1","ENSG00000179010","","","",31.3,55.6,39.4,35.1,28.3,30.3,1.3479188900747066,0.43073368612836543,0.21706233663183158,0.6634155262091798,0.44228150428531865,0.35430122195705116,3832]
["High","Q9Y606","tRNA pseudouridine synthase A [OS=Homo sapiens]",52,20,47,20,427,47.4,8.41,88.3,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","PUS1","ENSG00000177192","","","",1647.5,1753.2,1795.8,1641,1708,1671.4,1.0350768863038804,0.049737936197525805,0.2897836872174516,0.5379260659002021,0.5224269290680817,0.28197444497140906,4331]
["High","Q9Y608","Leucine-rich repeat flightless-interacting protein 2 [OS=Homo sapiens]",4,3,9,1,721,82.1,6.95,14.51,"cell-cell signaling;signal transduction;other biological processes","","other molecular function","LRRFIP2","ENSG00000093167","VEGFA-VEGFR2 signaling pathway","","",56.5,51.7,56.8,61.3,55.7,46.2,1.0110294117647058,0.01582496716168249,0.9047145822693194,0.043488409630178915,0.9520231075955319,0.02135251025057057,7420]
["High","Q9Y613","FH1/FH2 domain-containing protein 1 [OS=Homo sapiens]",28,19,40,19,1164,126.5,6.39,72.26,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FHOD1","ENSG00000135723","VEGFA-VEGFR2 signaling pathway","","Salmonella infection",531.7,552.9,512.6,597.5,559.5,549.2,0.9361153440393857,-0.09524179155168463,0.12454604097901968,0.9046700730916876,0.3208365186288966,0.4937162048006744,3031]
["High","Q9Y617-1","phosphoserine aminotransferase [OS=Homo sapiens]",68,22,169,21,370,40.4,7.66,380.51,"other metabolic processes","cytosol;other cell component","other molecular function","PSAT1","ENSG00000135069; ENSGGOG00000015480; ENSPPAG00000036829; ENSPTRG00000021045","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Vitamin B6 metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors",8520.3,8475.1,8913.4,8565.1,9706.1,9361,0.93763073515681,-0.09290823339132784,0.1910008268078783,0.7189647527662937,0.4074684305234737,0.389906033502069,3660]
["High","Q9Y618-1","Nuclear receptor corepressor 2 [OS=Homo sapiens]",6,14,22,13,2525,274.6,7.59,28.1,"","","","","","","","",1000.3,934.9,949.3,1058.1,993.8,996.3,0.9462961747916804,-0.07963630135552613,0.13214906180478342,0.8789359158047026,0.3322021489284446,0.478597562538607,3106]
["High","Q9Y619","mitochondrial ornithine transporter 1 [OS=Homo sapiens]",5,2,3,2,301,32.7,9.13,6.35,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A15","ENSG00000102743","","Urea cycle","",225.2,220.4,212.7,229.2,238.8,242.1,0.9270525278129839,-0.10927700903728414,0.031372972838293836,1.5034443265016721,0.14546328498895386,0.8372466090066673,1684]
["High","Q9Y620-1","DNA repair and recombination protein RAD54B [OS=Homo sapiens]",2,2,3,2,910,102.9,8.12,4.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RAD54B","ENSG00000197275","Homologous recombination; DNA repair pathways, full network","","Homologous recombination",74,89,64.1,65.4,68,64.1,1.149873417721519,0.20147505275506034,0.24941737489133972,0.6030732960194718,0.47943152711757275,0.3192734104296243,4062]
["High","Q9Y624","Junctional adhesion molecule A [OS=Homo sapiens]",51,12,53,12,299,32.6,7.9,98.69,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","F11R","ENSG00000158769","1q21.1 copy number variation syndrome","Integrin cell surface interactions; Tight junction interactions; Cell surface interactions at the vascular wall; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Epithelial cell signaling in Helicobacter pylori infection",2368.7,2545.9,2434,2514.6,2428,2476.9,0.990444100006739,-0.01385254220454558,0.7020930985306155,0.15360529599367145,0.8438951529136463,0.07371150756815495,6496]
["High","Q9Y625","Glypican-6 [OS=Homo sapiens]",9,3,3,2,555,62.7,5.41,9.71,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC6","ENSG00000183098","miR-509-3p alteration of YAP1/ECM axis","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","",8,16.4,15,16.3,14.6,12.4,0.9099307159353349,-0.13617139527034858,0.670143305841566,0.17383231628237103,0.8232345708009672,0.08447640015907756,6356]
["High","Q9Y639-1","Isoform 1 of Neuroplastin [OS=Homo sapiens]",33,8,26,8,282,31.3,6.87,63.74,"","","","NPTN","","","","",1260.3,1541,1298.7,1379,1220,1300.5,1.0514168483138866,0.07233475851599529,0.5371609132390628,0.26989559649136835,0.7345275675254995,0.13399190007858097,5710]
["Medium","Q9Y646","Carboxypeptidase Q [OS=Homo sapiens]",1,1,1,1,472,51.9,6.18,2.19,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CPQ","ENSG00000104324","","","",29.4,39.1,37,38.3,33.6,44.3,{"$f":"AVERAGE(T7746:V7746)/AVERAGE(W7746:Y7746)","v":0.9079173838209982},{"$f":"LOG(Z7746,2)","v":-0.13936706980998156},{"$f":"TTEST(T7746:V7746,W7746:Y7746,2,2)","v":0.4509578907883571},{"$f":"-LOG10(AB7746)","v":0.34586400945698287},{"$f":"AB7746*7808/AF7746","v":0.6677563457757428},{"$f":"-LOG10(AD7746)","v":0.17538197612981163},5273]
["High","Q9Y657","Spindlin-1 [OS=Homo sapiens]",47,10,30,9,262,29.6,6.96,54.87,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes","other membranes;cytosol;nucleus","other molecular function","SPIN1","ENSG00000106723","","","",880.3,904.4,828.9,998.3,1032.7,1008.6,0.8598499802605606,-0.21784312299559414,4.397615464276263E-3,2.356782748837023,0.052183254627764526,1.2824688377923432,658]
["High","Q9Y664","KICSTOR complex protein kaptin [OS=Homo sapiens]",11,4,6,4,436,48.1,5.26,6.99,"cell organization and biogenesis;stress response;other biological processes","other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity","KPTN","ENSG00000118162","","Amino acids regulate mTORC1","",98.3,83.5,80.8,59.1,76.4,80.7,1.2146160962072157,0.2805003931582368,0.14484535363919823,0.8390954315697934,0.35014009944732505,0.4557581492422608,3230]
["High","Q9Y666","Solute carrier family 12 member 7 [OS=Homo sapiens]",14,11,16,11,1083,119,6.71,33.91,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC12A7","ENSG00000113504","","Cation-coupled Chloride cotransporters","Collecting duct acid secretion",506.1,512.1,461.5,511.7,480.6,491.9,0.996968063603288,-0.004380804124589452,0.938834906920284,0.02741077122403569,0.9698892502293699,0.013277854146396,7558]
["High","Q9Y672","Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",6,3,9,3,507,58.1,8.46,18.36,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG6","ENSG00000088035","GPCRs, other","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG6 causes CDG-1c","N-Glycan biosynthesis; Metabolic pathways",416.3,393.1,425.8,391.7,400.8,428.1,1.0119613304932003,0.01715416219468993,0.7560467106809945,0.12145137174175626,0.8761075566929659,0.057442573728222326,6738]
["High","Q9Y673","dolichyl-phosphate beta-glucosyltransferase [OS=Homo sapiens]",17,4,5,4,324,36.9,9.28,10.28,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ALG5","ENSG00000120697","","Synthesis of dolichyl-phosphate-glucose","N-Glycan biosynthesis; Metabolic pathways",145.8,129,122.9,129.2,128.2,124.9,1.040282500653937,0.05697536197056294,0.5022425578793073,0.29908648981295655,0.7070879718574885,0.150526550396164,5546]
["High","Q9Y676","28S ribosomal protein S18b, mitochondrial [OS=Homo sapiens]",7,1,1,1,258,29.4,9.38,3.86,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPS18B","ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Viral carcinogenesis",16.8,30.9,24.9,39.2,24,23.9,0.8335246842709529,-0.2627031706031139,0.49976552111483913,0.3012337092061361,0.7057640059440521,0.15134049448623696,5529]
["High","Q9Y678","Coatomer subunit gamma-1 [OS=Homo sapiens]",57,37,115,33,874,97.7,5.47,252.96,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","COPG1","ENSG00000181789","VEGFA-VEGFR2 signaling pathway","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",3980.8,3866.4,4128.9,3756.8,4107.5,3986.9,1.010539017145943,0.015125025583324288,0.7610906715165306,0.11856360105653493,0.878432514885598,0.05629159733154135,6765]
["High","Q9Y679-1","Ancient ubiquitous protein 1 [OS=Homo sapiens]",11,6,16,6,476,53,8.09,37.45,"","","","","","","","",687,697.1,722.3,734.7,740.9,681.9,0.9763151796060254,-0.03458113290761695,0.4718046019092716,0.3262378273884142,0.6846032952439309,0.16456101477627275,5381]
["High","Q9Y692-1","Glucocorticoid modulatory element-binding protein 1 [OS=Homo sapiens]",17,8,12,7,573,62.6,4.83,30.46,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GMEB1","ENSG00000162419; ENSGGOG00000009221; ENSPPAG00000038756","","","",531.2,580.9,546.2,760.2,691.1,769.5,0.7467128962536022,-0.42137444728042583,2.864719110862236E-3,2.542917954702848,0.044204993710696326,1.354528666884012,506]
["High","Q9Y696","Chloride intracellular channel protein 4 [OS=Homo sapiens]",74,15,177,14,253,28.8,5.59,365.42,"transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","transporter activity","CLIC4","ENSG00000169504","","","",5927.6,5980,5768.6,6314.1,5928.9,5654.4,0.9876406628895816,-0.01794185891144845,0.7330941572644767,0.13484024179238427,0.863478530686534,0.06374845615127912,6629]
["High","Q9Y697","Cysteine desulfurase, mitochondrial [OS=Homo sapiens]",32,10,16,10,457,50.2,8.31,38.46,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","NFS1","ENSG00000244005","","","Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system",521.3,431.7,420.3,447.5,415.2,444.5,1.0505660954712361,0.07116693079620996,0.5473022552993819,0.261772762231954,0.7437062320531802,0.12859857922924733,5746]
["Low","Q9Y6A1","Protein O-mannosyl-transferase 1 [OS=Homo sapiens]",1,1,1,1,747,84.8,8.4,1.87,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","POMT1","ENSG00000130714","","O-linked glycosylation; Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2; Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1","Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Metabolic pathways",21.3,29.5,21.2,22.4,22.7,17.9,1.142857142857143,0.1926450779423961,0.39592947329198364,0.4023821678319428,0.6242765200855832,0.20462299918536897,4952]
["High","Q9Y6A4","Cilia- and flagella-associated protein 20 [OS=Homo sapiens]",54,8,19,8,193,22.8,9.76,32.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","","CFAP20","ENSG00000070761","","","",715.7,702,853.8,596,825.6,675.5,1.0831624624481426,0.11524964755371414,0.5220634091997222,0.28227674490369364,0.7227431026651473,0.14101604422840056,5640]
["High","Q9Y6A5","Transforming acidic coiled-coil-containing protein 3 [OS=Homo sapiens]",48,33,102,33,838,90.3,5.05,203.73,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","","TACC3","ENSG00000013810","","Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus","",4552.7,4905,4367.9,3591.5,2988.7,3141.8,1.4220942192964412,0.5080170523052152,0.004675034218940763,2.3302152059587873,0.053998028374984436,1.2676220972417875,676]
["High","Q9Y6A9","Signal peptidase complex subunit 1 [OS=Homo sapiens]",17,2,5,2,102,11.8,9.31,8.44,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","translation activity;other molecular function","SPCS1","ENSG00000114902","","","Protein export",320.7,318.4,305.2,295.5,299,283.6,1.0753900466917208,0.10486002387596496,0.03027567921928124,1.5189061049024346,0.1435291459284444,0.8430598994135536,1647]
["High","Q9Y6B6","GTP-binding protein SAR1b [OS=Homo sapiens]",31,6,24,2,198,22.4,6.11,44.54,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SAR1B","ENSG00000152700","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Chylomicron assembly","Protein processing in endoplasmic reticulum; Legionellosis",126.5,131.8,141.3,120.6,125.7,116.2,1.102344827586207,0.14057558800275946,0.0733599115670292,1.1345412008654943,0.2346555467084654,0.6295691756240475,2441]
["High","Q9Y6B7","AP-4 complex subunit beta-1 [OS=Homo sapiens]",5,2,3,2,739,83.2,5.86,0,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","AP4B1","ENSG00000134262","","Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis","Lysosome",31.5,38.3,48.9,35.5,46,33.9,1.028596187175043,0.04067671099642388,0.870423168762801,0.06026955752190552,0.9345797719609393,0.029383623077181124,7272]
["High","Q9Y6C9","Mitochondrial carrier homolog 2 [OS=Homo sapiens]",23,7,23,7,303,33.3,7.97,72.58,"other biological processes","other membranes;mitochondrion","","MTCH2","ENSG00000109919; ENSG00000285121","","","",1605,1934.7,1695.3,1456.3,1567.1,1589.3,1.1349101393977497,0.18257807145670407,0.12359274870232294,0.9080070089474387,0.31964630071803163,0.495330317311901,3019]
["High","Q9Y6D0","selenoprotein K [OS=Homo sapiens]",10,1,2,1,94,10.6,10.86,2.47,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","SELENOK","ENSG00000113811","Selenium micronutrient network","","",123.9,118,103,66.2,69.5,64.6,1.7219171243135296,0.7840157076481458,1.6508821767357844E-3,2.7822839211766026,0.03322187638132218,1.4785758421121746,388]
["High","Q9Y6D5","Brefeldin A-inhibited guanine nucleotide-exchange protein 2 [OS=Homo sapiens]",16,27,51,17,1785,201.9,6.33,82.37,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARFGEF2","ENSG00000124198","","Association of TriC/CCT with target proteins during biosynthesis","Endocytosis",760.5,810,803.2,844.8,866,873.1,0.9186501025581484,-0.12241262556645936,0.016605929389033124,1.7797368130958027,0.106017249934236,0.9746234654734528,1223]
["High","Q9Y6D6","Brefeldin A-inhibited guanine nucleotide-exchange protein 1 [OS=Homo sapiens]",29,38,88,28,1849,208.6,5.85,167.77,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","ARFGEF1","ENSG00000066777","","","Endocytosis",3588.4,3555.4,3749.9,4155.9,4418.1,4217.3,0.8516491677937349,-0.23166885237222268,0.003126220666308166,2.504980370277919,0.045370875395044905,1.343222841285673,538]
["High","Q9Y6D9","mitotic spindle assembly checkpoint protein MAD1 [OS=Homo sapiens]",40,31,76,31,718,83,5.92,179.87,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD1L1","ENSG00000002822","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; CCL18 signaling pathway","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Viral carcinogenesis",3110,3047.8,3025,2919.3,2905.5,2905,1.0518912231666246,0.07298552220435028,4.2697423944015565E-3,2.369598326395295,0.051447760209085425,1.288633527607253,648]
["High","Q9Y6E0","Serine/threonine-protein kinase 24 [OS=Homo sapiens]",38,13,53,8,443,49.3,5.69,111.9,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","STK24","ENSG00000102572","","Apoptotic cleavage of cellular proteins","",1317.9,1358.4,1182.9,1252.4,1170.4,1198.4,1.0657240693692698,0.09183395284116176,0.24491686786580566,0.6109813032020693,0.4747544449593373,0.32353096042501434,4028]
["High","Q9Y6E2","Basic leucine zipper and W2 domain-containing protein 2 [OS=Homo sapiens]",48,20,81,16,419,48.1,6.68,148.74,"developmental processes;other biological processes","other cell component","","BZW2","ENSG00000136261","","","",2336.6,2188.6,2352.2,2277.8,2426.4,2377.9,0.9710961437991555,-0.042313957517154166,0.3727770260478732,0.42855086071741605,0.6036173827004965,0.21923826210021555,4822]
["High","Q9Y6G5","COMM domain-containing protein 10 [OS=Homo sapiens]",12,2,3,2,202,23,6.54,2.65,"","nucleus;other cell component","","COMMD10","ENSG00000145781","","Neddylation","",25.3,23.4,25.6,27.2,23.8,23,1.0040540540540541,5.8369400222841985E-3,0.9486877558695257,0.022876704555415368,0.9747801023594231,0.011093344406990382,7599]
["High","Q9Y6G9","Cytoplasmic dynein 1 light intermediate chain 1 [OS=Homo sapiens]",59,24,78,24,523,56.5,6.42,187.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","DYNC1LI1","ENSG00000144635","Ciliary landscape; Intraflagellar transport proteins binding to dynein","Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MHC class II antigen presentation; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection",3354.1,3193.6,3441.4,3394.5,3507.3,3516.2,0.9588308696486851,-0.06065173745209758,0.1579931361228297,0.8013617801894437,0.3669275451656913,0.43541968463426045,3362]
["High","Q9Y6H1","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 [OS=Homo sapiens]",34,3,6,3,151,15.5,9.22,12.94,"cell organization and biogenesis;stress response;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","CHCHD2","ENSG00000106153","","Mitochondrial protein import","",190.7,199,186,244.9,210,214.9,0.859510301582562,-0.21841316379017917,0.053244641010354705,1.2737240967484014,0.19518035540321574,0.7095638955285036,2130]
["High","Q9Y6I3","epsin-1 [OS=Homo sapiens]",18,8,17,1,576,60.3,4.83,58.15,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","EPN1","ENSG00000063245","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway","Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation","Endocytosis",208.4,195.8,188.1,193.3,170.3,159,1.1333716035208574,0.18062096147497803,0.11798400824385874,0.9281768537286575,0.31206610310570765,0.505753402221026,2952]
["High","Q9Y6I3-1","Isoform 2 of Epsin-1 [OS=Homo sapiens]",16,8,17,1,662,69,5.05,58.01,"","","","EPN1","","","","",669.9,677.4,639.1,635.2,573,563.9,1.1209299700919815,0.16469614883297506,0.04757475537389792,1.3226234361473928,0.18444075966206305,0.7341430977063566,2014]
["High","Q9Y6I4-1","Ubiquitin carboxyl-terminal hydrolase 3 [OS=Homo sapiens]",21,8,11,8,520,58.9,8.18,20.69,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","USP3","ENSG00000140455","","Ub-specific processing proteases","",451,488.4,473.9,522.9,506,536.8,0.9026633454684805,-0.14774006995259772,0.022520956443674044,1.6474131693540215,0.12160693493236993,0.9150416576538982,1446]
["High","Q9Y6I9","Testis-expressed protein 264 [OS=Homo sapiens]",15,3,6,3,313,34.2,4.86,12.37,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TEX264","ENSG00000164081","","Platelet degranulation","",243,250.4,267.3,274.8,255.9,222,1.0106284044107878,0.015252633580978503,0.8832087714748469,0.05393662645340916,0.941189311815969,0.02632301333377927,7327]
["High","Q9Y6J0","Calcineurin-binding protein cabin-1 [OS=Homo sapiens]",7,11,17,11,2220,246.2,6.02,37.06,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity","CABIN1","ENSG00000099991","","Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",719.3,664.7,672.2,679.6,656.9,670,1.0247694991278344,0.03529944157297283,0.41675551056539767,0.38011864898688646,0.6413139587100167,0.192929307213963,5074]
["High","Q9Y6J9","TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L [OS=Homo sapiens]",15,7,13,7,622,67.8,8.97,17.17,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF6L","ENSG00000162227","","HATs acetylate histones","Basal transcription factors",571,583,586.1,613.2,611.7,637.8,0.9341815643957696,-0.09822512033075485,0.013237688469808318,1.8781878436311947,0.09404901871907492,1.02664573139605,1099]
["High","Q9Y6K1","DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",44,31,99,4,912,101.8,6.57,170.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT3A","ENSG00000119772","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency","RMTs methylate histone arginines; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer",2838.3,2690.9,2980.1,3055.6,3133.7,3100.2,0.9160127025135908,-0.1265604903137242,0.03968542011540175,1.4013690178319502,0.16740343612158665,0.7762356319262189,1851]
["High","Q9Y6K1-2","Isoform 2 of DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",49,28,94,1,723,81.6,6.81,160.75,"","","","DNMT3A","","","","",36.3,33.3,30.7,40.9,45.7,42.9,0.7745173745173745,-0.3686304919617357,0.010336692492807215,1.9856184033998159,0.08277835382957818,1.0820832144397172,975]
["Medium","Q9Y6K5","2'-5'-oligoadenylate synthase 3 [OS=Homo sapiens]",1,1,1,1,1087,121.1,8.4,2.19,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS3","ENSG00000111331","Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction","Interferon gamma signaling; OAS antiviral response; Interferon alpha/beta signaling","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease",22.2,17.5,23.3,20.3,21.8,25.2,0.9361069836552749,-0.09525467622303826,0.5660347291410006,0.2471569217947877,0.7553579157636188,0.12184721524687052,5851]
["High","Q9Y6K8","Adenylate kinase isoenzyme 5 [OS=Homo sapiens]",8,3,3,3,562,63.3,5.07,8.18,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK5","ENSG00000154027","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors",60.6,66.8,61.9,87.3,68.3,89.5,0.7723378212974296,-0.3726960731631345,0.056329392703594,1.2492649309393296,0.20184483626877558,0.6949823565269497,2179]
["High","Q9Y6K9","NF-kappa-B essential modulator [OS=Homo sapiens]",10,4,4,4,419,48.2,5.71,10.06,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IKBKG","ENSG00000269335","Nucleotide-binding oligomerization domain (NOD) pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","Downstream TCR signaling; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; TICAM1, RIP1-mediated IKK complex recruitment; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Ovarian tumor domain proteases; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Primary immunodeficiency; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",311.4,284.4,210.8,307,220.2,234.6,1.05880808611184,0.08244111784253569,0.7298282599982348,0.13677932413981164,0.8610606004935353,0.06496628230501052,6618]
["High","Q9Y6M1","Insulin-like growth factor 2 mRNA-binding protein 2 [OS=Homo sapiens]",42,22,106,19,599,66.1,8.46,221.34,"transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP2","ENSG00000073792","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",2871,3066.3,2898.3,3260.3,3145.4,3144,0.9252227818674932,-0.11212730482916491,0.030026548871288847,1.522494580964043,0.142868551850715,0.8450633573585009,1641]
["High","Q9Y6M4-4","Isoform 4 of Casein kinase I isoform gamma-3 [OS=Homo sapiens]",13,4,6,1,424,49,9.11,8.8,"","","","CSNK1G3","","","","",15.3,14.1,16.9,16.2,11.2,11.4,1.193298969072165,0.2549555410731087,0.2424878062795932,0.6153100954065959,0.47286333452324275,0.32526435955524147,4004]
["High","Q9Y6M5","zinc transporter 1 [OS=Homo sapiens]",31,10,20,10,507,55.3,6.48,52.13,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A1","ENSG00000170385","Zinc homeostasis","Zinc efflux and compartmentalization by the SLC30 family","Mineral absorption",566.7,573.4,551.4,489.9,507.5,489.5,1.1376017217028718,0.1859955535178521,1.4995887685002145E-3,2.8240278209823133,0.03199122706133791,1.4949691017180886,366]
["High","Q9Y6M7-7","Isoform 7 of Sodium bicarbonate cotransporter 3 [OS=Homo sapiens]",12,16,29,16,1259,140.7,6.62,38.28,"","","","SLC4A7","","","","",914.2,878.9,1023.7,970,1099.4,1050.4,0.9028783896403616,-0.14739641335825904,0.15463553367139649,0.8106907024991539,0.3625808549268059,0.44059513134683836,3330]
["Medium","Q9Y6N6","Laminin subunit gamma-3 [OS=Homo sapiens]",1,1,1,1,1575,171.1,6.58,0,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes","other molecular function","LAMC3","ENSG00000050555","Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Small cell lung cancer; Malignant pleural mesothelioma","Non-integrin membrane-ECM interactions; Laminin interactions; MET activates PTK2 signaling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer",32.8,28,36.6,24.7,36.7,29.6,1.0703296703296705,0.09805522699628381,0.6443971398021409,0.19084639589233554,0.8060642210149177,0.09363035556301398,6242]
["High","Q9Y6N7","Roundabout homolog 1 [OS=Homo sapiens]",9,12,16,12,1651,180.8,6.04,30.93,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ROBO1","ENSG00000169855","Development of ureteric collection system","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; SLIT2:ROBO1 increases RHOA activity","Axon guidance",611,611.5,611.8,580.1,538.4,510.4,1.1260973663208298,0.17133157327540338,0.02776289594250031,1.556535234677892,0.13616375095417238,0.8659384934209068,1592]
["High","Q9Y6P5","Sestrin-1 [OS=Homo sapiens]",5,2,2,2,492,56.5,6.09,4.43,"other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","SESN1","ENSG00000080546","miRNA regulation of DNA damage response; Mesodermal commitment pathway; Head and neck squamous cell carcinoma; p53 transcriptional gene network; DNA damage response","Amino acids regulate mTORC1","p53 signaling pathway; Longevity regulating pathway",71.7,87.7,79.3,62.1,61.9,63.1,1.2757883484767503,0.35138900784099236,0.020646705331617998,1.68514924039767,0.11767114980238928,0.9293300028954413,1370]
["High","Q9Y6Q1","Calpain-6 [OS=Homo sapiens]",5,3,3,3,641,74.5,7.05,6.71,"cell organization and biogenesis;protein metabolism;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CAPN6","ENSG00000077274","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",87.2,95.1,95.9,121.4,139.5,135.2,0.7023478919464783,-0.5097422813623803,3.0321955971337232E-3,2.5182427872035813,0.04467053438192474,1.349978852145735,530]
["High","Q9Y6Q2-3","Isoform 3 of Stonin-1 [OS=Homo sapiens]",11,8,10,7,1135,127.2,5.31,16.27,"","","","STON1","","","","",386.2,391,401.4,503.6,496.4,487,0.7926025554808338,-0.33533047608817435,9.7688429206846974E-5,4.010156873632393,0.010896446503529446,1.9627151089880146,70]
["High","Q9Y6Q3-1","zinc finger protein 37 homolog [OS=Homo sapiens]",15,7,7,6,630,71.2,9.09,11.29,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZFP37","ENSG00000136866","","Generic Transcription Pathway","Herpes simplex virus 1 infection",178.3,185.2,184.4,224.1,222.8,215.8,0.826769277199336,-0.27444331577045145,3.4499075158084372E-4,3.4621925472201824,0.017267229412456588,1.7627773409160088,156]
["High","Q9Y6Q9-1","Nuclear receptor coactivator 3 [OS=Homo sapiens]",4,4,4,4,1424,155.2,7.47,2.79,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NCOA3","ENSG00000124151","Androgen receptor signaling pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway","Estrogen-dependent gene expression; MAPK6/MAPK4 signaling; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Endocrine resistance; Estrogen signaling pathway; Thyroid hormone signaling pathway; Pathways in cancer; Breast cancer",146.1,143.5,131.5,113.1,100.5,114.5,1.2834501676318195,0.36002728165067416,0.008047730489296055,2.0943265761464245,0.07132426749196775,1.1467626798998372,881]
["High","Q9Y6R0","Numb-like protein [OS=Homo sapiens]",10,5,9,3,609,64.9,8.85,22.59,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction","other cell component","","NUMBL","ENSG00000105245","Notch signaling; Notch signaling pathway","","Notch signaling pathway",104.8,122.1,103.1,104.5,103.1,93.1,1.0974393082806784,0.1341411565591752,0.23829132661023575,0.6228917649295227,0.4686596166681916,0.3291424670340024,3970]
["High","Q9Y6R4-1","Mitogen-activated protein kinase kinase kinase 4 [OS=Homo sapiens]",6,9,15,9,1608,181.6,6.32,20.28,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","kinase activity;other molecular function","MAP3K4","ENSG00000085511","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)","","MAPK signaling pathway; GnRH signaling pathway",439.3,446.1,429.5,436.8,422.2,450.3,1.0042770946307187,0.006157384721261877,0.8528372631469312,0.0691338322087572,0.9288538639491196,0.03205260793615789,7169]
["Medium","Q9Y6V0-1","Protein piccolo [OS=Homo sapiens]",0,1,4,1,5065,552.9,6.51,8.88,"","","","","","","","",88,93,74.4,76,66.6,85,1.1221441124780318,0.16625796739614213,0.2944885202219161,0.5309316302536153,0.5272566764257557,0.27797791226840646,4361]
["High","Q9Y6V7","Probable ATP-dependent RNA helicase ddx49 [OS=Homo sapiens]",14,4,9,4,483,54.2,9.06,20.08,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX49","ENSG00000105671","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",285.2,272.8,300.5,255.4,298.1,279.8,1.0302412096483862,0.04298215412966363,0.5991453776491117,0.22246778687549254,0.7783905338908925,0.10880245421959665,6010]
["High","Q9Y6W3","Calpain-7 [OS=Homo sapiens]",18,11,17,11,813,92.6,7.65,31.21,"protein metabolism;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CAPN7","ENSG00000131375","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",468.5,472,489.5,519.5,526,485.8,0.9338470580552473,-0.09874180475194164,0.07409539066296433,1.1302088078358266,0.2362338955885772,0.6266577883019053,2449]
["High","Q9Y6W5","Wiskott-Aldrich syndrome protein family member 2 [OS=Homo sapiens]",17,10,22,10,498,54.3,5.53,38.22,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","WASF2","ENSG00000158195","Regulation of actin cytoskeleton","RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs","Adherens junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Choline metabolism in cancer",1087.4,994.9,964.4,1081.8,1048,977.5,0.9804975380555467,-0.028414086947768615,0.6959622859002934,0.15741429410951413,0.8398877168948209,0.07577877011957909,6470]
["High","Q9Y6X2","E3 SUMO-protein ligase PIAS3 [OS=Homo sapiens]",3,2,2,2,628,68,7.69,5.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","PIAS3","ENSG00000131788","Androgen receptor signaling pathway; Prolactin signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; EGF/EGFR signaling pathway; Regulatory circuits of the STAT3 signaling pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Interferon type I signaling pathways","SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMOylation of immune response proteins; SUMOylation of DNA replication proteins","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway",52.3,48,55.2,46.9,54.5,55,0.9942455242966752,-8.325932289387333E-3,0.9330064445443703,0.03011535644600571,0.9665535782144677,0.014774067059160078,7537]
["High","Q9Y6X3-1","MAU2 chromatid cohesion factor homolog [OS=Homo sapiens]",5,2,2,2,613,69,7.25,5.55,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MAU2","ENSANAG00000026794; ENSCANG00000033671; ENSCATG00000015302; ENSCCAG00000031923; ENSCSAG00000005122; ENSG00000129933; ENSGGOG00000002989; ENSMFAG00000041829; ENSMNEG00000034232; ENSPPAG00000032359; ENSPTRG00000010738; ENSRBIG00000036077; ENSRROG00000032649; ENSSBOG00000034577","Cohesin complex - Cornelia de Lange syndrome","Cohesin Loading onto Chromatin","",83.8,97.1,86.2,117.6,90.3,96.8,0.876599934361667,-0.19000952405137597,0.24451933063386516,0.6116868017519475,0.4748089862196516,0.3234810701962232,4021]
["High","Q9Y6X4-1","Soluble lamin-associated protein of 75 kDa [OS=Homo sapiens]",13,6,9,6,670,74.9,4.6,21.39,"","other membranes;nucleus","","FAM169A","ENSG00000198780","","RHOF GTPase cycle","",321.5,325.9,333.6,419.5,423.6,400.4,0.7889022919179735,-0.34208146599766787,3.9214404698949094E-4,3.406554373486323,0.018010945405258504,1.7444634902059617,170]
["High","Q9Y6X5","Bis(5'-adenosyl)-triphosphatase ENPP4 [OS=Homo sapiens]",5,2,2,2,453,51.6,6.15,2.38,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes","other molecular function","ENPP4","ENSG00000001561","","Neutrophil degranulation","Purine metabolism; Metabolic pathways",9.2,12.7,15,12.6,11.3,16.5,0.9133663366336633,-0.13073447669139882,0.6384984251193419,0.1948401696031078,0.801897330437803,0.09588123231262821,6217]
["High","Q9Y6X8","Zinc fingers and homeoboxes protein 2 [OS=Homo sapiens]",2,2,2,2,837,92.3,6.86,3.13,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZHX2","ENSG00000178764","","","",56.4,50.7,49.4,55.2,62.4,55.6,0.903579676674365,-0.14627627290674405,0.1543961726196098,0.8113634697437152,0.3623460522434365,0.44087646595390234,3327]
["High","Q9Y6X9-1","MORC family CW-type zinc finger protein 2 [OS=Homo sapiens]",23,18,39,18,1032,117.8,8.38,66.76,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","MORC2","ENSG00000133422","","Fatty acyl-CoA biosynthesis","",1825.4,1809.7,1807,1677,1681.6,1743.3,1.066681040396715,0.09312884511273997,0.006866897541952411,2.163239432480071,0.0654661001313363,1.1839835295818537,819]
["High","Q9Y6Y0","influenza virus NS1A-binding protein [OS=Homo sapiens]",10,5,7,5,642,71.7,5.53,11.53,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","IVNS1ABP","ENSG00000116679","","","",291.9,268.4,287.7,522.2,624.7,581.2,0.49071234303570394,-1.0270505344809322,0.000659036110813932,3.1810907882928414,0.023179071861419737,1.6349039580848446,222]
["High","Q9Y6Y8","SEC23-interacting protein [OS=Homo sapiens]",14,16,38,16,1000,111,5.54,49.87,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC23IP","ENSG00000107651","","COPII-mediated vesicle transport","",1155.1,1122.3,1161.4,1283.9,1198.4,1250.3,0.9212881101644965,-0.11827570067083334,0.024016292477258578,1.6194940361065497,0.12543091081099328,0.9015954241083629,1495]

{"sheet":"CF3-P","index":5,"n_rows":7809,"n_cols":32,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["Protein FDR Confidence: Combined","Accession","Description","Coverage [%]","# Peptides","# PSMs","# Unique Peptides","# AAs","MW [kDa]","calc. pI","Score Sequest HT: Sequest HT","Biological Process","Cellular Component","Molecular Function","Gene Symbol","Ensembl Gene ID","WikiPathways","Reactome Pathways","KEGG Pathways","Abundances (Normalized): F19: 133N, Sample, CF3-P","Abundances (Normalized): F19: 134N, Sample, CF3-P","Abundances (Normalized): F19: 135N, Sample, CF3-P","Abundances (Normalized): F19: 126, Sample, DMSO","Abundances (Normalized): F19: 127C, Sample, DMSO","Abundances (Normalized): F19: 128C, Sample, DMSO","Ratio","log2(Ratio)","P-Value","− log10(P-Value)","q-Value","− log10(q-Value)","Rank (P-Value)"]
["Medium","A0A0B4J2F0","Protein PIGBOS1 [OS=Homo sapiens]",19,1,1,1,54,6.3,8.5,0,"stress response;other biological processes","other membranes;mitochondrion","","PIGBOS1","ENSG00000225973","","","",58.3,56,46.1,51.5,54.7,56.6,{"$f":"AVERAGE(T2:V2)/AVERAGE(W2:Y2)","v":0.9852579852579851},{"$f":"LOG(Z2,2)","v":-0.021426557811326918},{"$f":"TTEST(T2:V2,W2:Y2,2,2)","v":0.8522427957615233},{"$f":"-LOG10(AB2)","v":0.06943666129207897},{"$f":"AB2*7808/AF2","v":0.9282064094442702},{"$f":"-LOG10(AD2)","v":0.03235543701947967},7169]
["High","A0AV96","RNA-binding protein 47 [OS=Homo sapiens]",13,6,11,6,593,64.1,7.68,29.14,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","RBM47","ENSG00000163694","TYROBP causal network in microglia","","",265.9,238.9,252.5,338,389.1,365.5,0.6931173347977302,-0.5288284943260179,2.5906401568734404E-3,2.5865929068664752,0.04387791398019051,1.3577540275974878,461]
["High","A0AVF1","intraflagellar transport protein 56 [OS=Homo sapiens]",10,4,5,4,554,64.1,6.93,8.28,"cell organization and biogenesis;transport;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","TTC26","ENSG00000105948","Ciliary landscape; Genes related to primary cilium development (based on CRISPR)","Intraflagellar transport","",144.2,162.7,154.5,164.5,182.6,155.9,0.9172962226640159,-0.12454039600990675,0.21880120743409964,0.6599502857183149,0.44863440852033876,0.3481074207721163,3808]
["High","A0AVT1-1","Ubiquitin-like modifier-activating enzyme 6 [OS=Homo sapiens]",33,26,66,26,1052,117.9,6.14,133.34,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBA6; UBE1L2","ENSG00000033178","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",2169.8,2171.1,2184.8,2226.3,2165.4,2198.9,0.990152641641125,-0.014277147105573767,0.30151068043031803,0.5206972992127307,0.5389641467032792,0.268440124250776,4368]
["High","A0FGR8-2","Isoform 2 of Extended synaptotagmin-2 [OS=Homo sapiens]",17,12,21,12,893,98.8,8.68,40.11,"","","","ESYT2","","","","",721.1,741,747,655.7,659.6,616.4,1.143604079308381,0.19358767127566334,4.3141062950772914E-3,2.3651091585388033,0.05651768783886491,1.2478156136204044,596]
["High","A0JLT2","Mediator of RNA polymerase II transcription subunit 19 [OS=Homo sapiens]",11,1,1,1,244,26.3,9.82,3.66,"other biological processes","nucleus","other molecular function","MED19","ENSG00000156603","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",34.3,29.1,29.1,28.4,27.5,26.2,1.1266747868453106,0.17207114362586973,0.1337914977240642,0.8735714845416379,0.338840095436099,0.47000520460951084,3083]
["High","A0JNW5-1","UHRF1-binding protein 1-like [OS=Homo sapiens]",16,14,18,14,1464,164.1,6.32,42.2,"","cytosol;other cytoplasmic organelle","other molecular function","UHRF1BP1L","ENSG00000111647","","RND2 GTPase cycle","",705.2,635.7,668.9,616.9,586.5,595.9,1.1169899405324293,0.15961619315396908,0.03318723754698373,1.4790288960707998,0.15378394704264034,0.8130889966195219,1685]
["High","A0MZ66","Shootin-1 [OS=Homo sapiens]",29,17,34,17,631,71.6,5.33,61.53,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SHTN1","ENSG00000187164","","Recycling pathway of L1","",1121.3,1224.3,1202.1,1363.7,1291.1,1246.9,0.9092703180664837,-0.13721883615725342,0.06320142682714239,1.1992731170315423,0.22030211636889632,0.6569813307070697,2240]
["Medium","A0PJW6","Transmembrane protein 223 [OS=Homo sapiens]",4,1,1,1,202,22,11.02,0,"developmental processes","other membranes","","TMEM223","ENSG00000168569","","","",81.4,70.4,53.4,72.8,60.3,73.5,0.9932236205227495,-0.009809523258005168,0.9619950871067345,0.01682714589137997,0.9822489394702999,7.7784314216745205E-3,7647]
["Medium","A0PJZ3","Glucoside xylosyltransferase 2 [OS=Homo sapiens]",2,1,1,1,443,51,9.77,0,"protein metabolism;other metabolic processes","other membranes","other molecular function","GXYLT2","ENSG00000172986","Vitamin D receptor pathway","","Other types of O-glycan biosynthesis",31.4,27.5,29.5,23.5,27.1,26.6,1.145077720207254,0.19544552212335126,0.078984038205795,1.1024606659190441,0.2510001507166656,0.6003260177404895,2457]
["High","A0PK00","Transmembrane protein 120B [OS=Homo sapiens]",9,2,3,2,339,40.2,8.9,8.9,"cell organization and biogenesis;transport;other biological processes","other membranes;nucleus","","TMEM120B","ENSG00000188735","","","",99.9,121.5,132.5,105,131.5,116.9,1.0014148273910581,2.0397218736133184E-3,0.9898080295375609,0.004449027419477155,0.9952892588060882,0.0020506828254191,7765]
["Medium","A1A5C7-1","Solute carrier family 22 member 23 [OS=Homo sapiens]",1,1,1,1,686,73.7,7.74,2.24,"transport","other membranes","transporter activity","SLC22A23","ENSG00000137266","","","",104.8,92.9,89,128.9,96.6,105.7,0.8656400966183575,-0.20816076825880156,0.23886728980448563,0.6218433179354962,0.4707409890947561,0.3272179844793891,3962]
["High","A1L020","RNA-binding protein MEX3A [OS=Homo sapiens]",22,8,18,8,520,54.1,7.27,58.94,"","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MEX3A","ENSG00000254726","","","",516,518.4,536.2,630.8,595.1,607.7,0.8565663176265271,-0.22336314699365137,0.002012532946020428,2.696257001316489,0.039882886402354066,1.3992134184834273,394]
["High","A1L0T0","Acetolactate synthase-like protein [OS=Homo sapiens]",22,11,18,11,632,67.8,8.15,54.07,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ILVBL","ENSG00000105135","","","",765.5,801.9,830,718.7,838.7,802.7,1.015804415067158,0.022622649574979493,0.7723114351572072,0.11220753477329667,0.8810940510969425,0.05497773098372391,6844]
["High","A1L170","Uncharacterized protein C1orf226 [OS=Homo sapiens]",8,1,1,1,272,29,5.27,3.81,"","","","C1orf226","ENSG00000239887","","","",42.6,30.6,40.6,37.7,32.4,29.6,1.1414242728184556,0.1908351479083863,0.3462667192702596,0.46058924778593874,0.5831860535078056,0.23419287041886172,4636]
["High","A1X283","SH3 and PX domain-containing protein 2B [OS=Homo sapiens]",22,17,37,17,911,101.5,8.69,68.96,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytoskeleton;other cell component","enzyme regulator activity;other molecular function","SH3PXD2B","ENSG00000174705","","","",1694.3,1777.1,1760,1822.6,1692.6,1699.3,1.0032409627001628,0.004668160228167848,0.9143997998345501,0.038863877681409705,0.9596281770306676,0.017897008568653023,7440]
["High","A2AJT9-1","BCLAF1 and THRAP3 family member 3 [OS=Homo sapiens]",9,6,7,6,711,83.8,9.7,7.11,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","BCLAF3","ENSG00000173681","","","",356.9,337.4,362,357.1,344.1,359.4,0.9959456911182349,-5.861020556458537E-3,0.879611717679006,0.05570899385258757,0.9426308388193355,0.025658356099849303,7286]
["High","A2RRP1-1","neuroblastoma-amplified sequence [OS=Homo sapiens]",8,15,28,15,2371,268.4,5.96,49.89,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","NBAS","ENSG00000151779","","COPI-dependent Golgi-to-ER retrograde traffic","",1140.2,1173.6,1127.2,1131.1,1232.1,1154.8,0.9781125639567936,-0.0319275907349799,0.48603726717767765,0.3133304296901523,0.6965820451768184,0.15702772393624564,5448]
["High","A2RTX5","Probable threonine--tRNA ligase 2, cytoplasmic [OS=Homo sapiens]",7,4,5,4,802,92.6,6.05,12.01,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","TARS3","ENSG00000185418","","","Aminoacyl-tRNA biosynthesis",107.2,117.3,124.1,135.7,126.2,131.5,0.8861209964412812,-0.1744243881528451,0.05673871055531397,1.246120538210154,0.2095628439053413,0.6786857165229259,2114]
["High","A2RU67","Protein FAM234B [OS=Homo sapiens]",2,1,2,1,622,67,5.02,6.52,"","other membranes;cytoskeleton;ER/Golgi","","FAM234B","ENSG00000084444","","","",70,75.9,69.6,84.8,85.6,90.6,0.8256704980842912,-0.2763619374807864,0.005123484015156881,2.29043461441793,0.0605206704846368,1.218096269244935,661]
["Medium","A2RUB1","Meiosis-specific coiled-coil domain-containing protein MEIOC [OS=Homo sapiens]",1,1,1,1,952,107.5,7.12,1.86,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","MEIOC","ENSG00000180336","","","",17.5,23.2,24.6,34.2,28.7,27.7,0.7207505518763797,-0.47242805849980435,0.04671438339052414,1.330549379276145,0.1866662771306103,0.7289341340002636,1954]
["High","A2RUC4","tRNA wybutosine-synthesizing protein 5 [OS=Homo sapiens]",18,5,6,5,315,36.5,7.55,9.39,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TYW5","ENSG00000162971","","Synthesis of wybutosine at G37 of tRNA(Phe)","",188.8,195,180.2,180.7,191.2,169.2,1.0423211975605249,0.059799921303704436,0.3757594833538788,0.4250900499525321,0.6084467121582509,0.21577745133533155,4822]
["High","A2VDJ0","Transmembrane protein 131-like [OS=Homo sapiens]",1,1,1,1,1609,179.2,6.86,2.49,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","TMEM131L","ENSG00000121210","","","",50.5,59,59.6,50.6,64.3,55.7,0.9912075029308323,-0.012740986908307075,0.924576095561097,0.03405733921300566,0.964345465420925,0.015767357332773378,7486]
["High","A3KMH1","von Willebrand factor A domain-containing protein 8 [OS=Homo sapiens]",12,16,18,16,1905,214.7,7.4,32.67,"","mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","VWA8","ENSG00000102763","","","",466.6,485.4,480.1,498.2,526.8,507.2,0.9346691032502283,-0.0974723904142329,0.030101485424292227,1.5214120726567908,0.1472634073890186,0.8319051550128661,1596]
["High","A3KN83-1","protein strawberry notch homolog 1 [OS=Homo sapiens]",21,17,54,17,1393,154.2,7.88,87.98,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SBNO1","ENSG00000139697","","","",1003.3,1052.6,1013,951.9,922.4,922.1,1.0974467172078386,0.1341508963108965,0.007292089860070004,2.1371479881942297,0.07161841210997055,1.1449753121920645,795]
["High","A4D1E9-1","GTP-binding protein 10 [OS=Homo sapiens]",13,5,13,5,387,42.9,9.03,25.82,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","GTPBP10","ENSG00000105793","","","",881.8,898,924.2,844.2,903.5,917.3,1.0146341463414634,0.02095961863564614,0.6383158925202526,0.19496434255448655,0.8006378295258043,0.09656389366362512,6225]
["Medium","A4D1F6","Leucine-rich repeat and death domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,860,98,7.46,0,"signal transduction;other biological processes","","","LRRD1","ENSG00000240720","","","",18.5,14.2,18.9,17.4,16.8,18.8,0.9735849056603773,-0.03862129402730756,0.7872157117657036,0.1039062465570867,0.8888763958736968,0.05115862634378071,6915]
["High","A4D1P6-1","WD repeat-containing protein 91 [OS=Homo sapiens]",3,1,1,1,747,83.3,6.58,4.28,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle","enzyme regulator activity","WDR91","ENSG00000105875","","CDC42 GTPase cycle","",40.4,32.5,28.4,29,30.9,35.5,1.0618448637316564,0.08657300279562696,0.6499459799877895,0.18712273807737134,0.8083431366270565,0.09240424478275953,6278]
["High","A4D1S0-1","killer cell lectin-like receptor subfamily G member 2 [OS=Homo sapiens]",21,8,17,8,409,42.8,5.87,31.59,"","other membranes","other molecular function","KLRG2","ENSG00000188883","","","",817.5,755.5,726.4,739.8,625.8,634.6,1.1495850414958506,0.20111319455214685,0.09307798258599338,1.0311530383769898,0.2741429226825486,0.5620229614514478,2651]
["High","A5A3E0","POTE ankyrin domain family member F [OS=Homo sapiens]",11,10,366,1,1075,121.4,6.2,713.12,"","other cell component","","POTEF","ENSG00000196604","","","",38.2,38.3,36.9,28.7,33.4,31.7,1.2089552238805972,0.2737608124268525,0.010674607317787396,1.9716480922143973,0.08435964973409311,1.07386523214339,988]
["High","A5LHX3","proteasome subunit beta type-11 [OS=Homo sapiens]",5,1,1,1,300,32.5,6.46,2.96,"protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","other molecular function","PSMB11","ENSG00000222028","","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling","Proteasome",37.6,37.5,29.2,37,30,28.3,1.0944386149003147,0.13019103860982364,0.4795574816441606,0.31915932913008366,0.691100925927945,0.16045852516859765,5418]
["High","A5PLN9-1","Trafficking protein particle complex subunit 13 [OS=Homo sapiens]",16,4,6,4,417,46.5,5.6,10.22,"","cytosol;ER/Golgi","","C5orf44; TRAPPC13","ENSG00000113597","","RAB GEFs exchange GTP for GDP on RABs","",146.2,142.2,139.1,145.9,151.6,136.6,0.9847961299239806,-0.022103002592258343,0.6724173503777775,0.17236108899206712,0.8221476153695093,0.08505019853685782,6386]
["High","A5YKK6","CCR4-NOT transcription complex subunit 1 [OS=Homo sapiens]",22,46,128,46,2376,266.8,7.11,215.71,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","CNOT1","ENSG00000125107","Ciliary landscape","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",4328.8,4445.3,4402.6,4511.5,4713.7,4706.3,0.9458206223306895,-0.0803614967479497,0.027781401187120823,1.556245853901192,0.14076390685855897,0.851508687960976,1541]
["High","A6H8Y1","Transcription factor TFIIIB component B'' homolog [OS=Homo sapiens]",1,3,4,3,2624,293.7,5.11,5.2,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","BDP1","ENSG00000145734; ENSG00000273873","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter","",287.4,293.2,298.9,330,343.8,316.3,0.8882941117058882,-0.17089066690737564,0.012802460196163299,1.8927065657465256,0.09264282596074425,1.0331882057708008,1079]
["Medium","A6NCS6","Uncharacterized protein C2orf72 [OS=Homo sapiens]",5,2,2,2,295,30.5,8.34,2.29,"","","","C2orf72","ENSG00000204128","","","",138.2,126.3,132.7,133.6,127.6,129.3,1.0171574903969272,0.024543074499032407,0.5952069158455664,0.22533203126574314,0.7718610860192963,0.11246085381425569,6021]
["High","A6ND36-1","Protein FAM83G [OS=Homo sapiens]",4,3,4,3,823,90.8,6.39,4.73,"signal transduction","cytosol;nucleus","other molecular function","FAM83G","ENSG00000188522","","","",103,121.2,130.9,124.5,118.9,103.5,1.0236379360046124,0.033705519734589476,0.804019254607502,0.09473355066739432,0.899782476705658,0.04586246898790266,6977]
["High","A6NDB9","Paralemmin-3 [OS=Homo sapiens]",9,6,8,6,673,71.7,4.53,23.73,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PALM3","ENSG00000187867; ENSG00000288318","","","",295.2,340.4,321.5,368.5,301.4,306.7,0.9800327667417571,-0.029098109306894642,0.8092719246645736,0.09190552592988759,0.9032011417640067,0.044215522077891124,6996]
["High","A6NDG6","glycerol-3-phosphate phosphatase [OS=Homo sapiens]",46,10,23,10,321,34,6.14,47.54,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","PGP","ENSG00000184207","","Glycolysis","Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism",1025.6,1017.4,1029.9,1068.3,979.5,1018.4,1.0021851151262149,0.003149015527238411,0.9355770876342794,0.028920422642967666,0.9701176494353856,0.01317559418503284,7530]
["High","A6NDU8","UPF0600 protein C5orf51 [OS=Homo sapiens]",45,9,22,9,294,33.6,5.26,31.35,"","cytosol;nucleus","","C5orf51","ENSG00000205765","","","",636.5,647.9,614.8,624.8,622.6,610.4,1.0222844224351382,0.031796642214109,0.26633832427528303,0.5745663370393159,0.5021902042843299,0.2991317628830585,4141]
["High","A6NED2","RCC1 domain-containing protein 1 [OS=Homo sapiens]",8,2,3,2,376,40.1,5.27,11.52,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;other cell component","","RCCD1","ENSG00000166965","","","",170.3,154.9,162,157.9,145.6,173,1.022455403987408,0.03203791910902802,0.714722246292456,0.14586269993088152,0.8486239809993151,0.07128469980424008,6576]
["High","A6NFI3","Zinc finger protein 316 [OS=Homo sapiens]",2,2,4,2,1004,108.4,5.31,7.23,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF316","ENSG00000205903","","","Herpes simplex virus 1 infection",296.9,275.5,296.3,385.8,341.7,377.7,0.7860115816141874,-0.3473775246245312,0.006686643387990476,2.1747918379721844,0.06842635854971119,1.1647765712684295,763]
["High","A6NGB9","WAS/WASL-interacting protein family member 3 [OS=Homo sapiens]",4,1,1,1,483,49.4,10.15,2.69,"other biological processes","cytosol;cytoskeleton","cytoskeletal activity","WIPF3","ENSG00000122574","","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs","Endocytosis; Pathogenic Escherichia coli infection; Yersinia infection",19.6,18,23.5,15.5,22.9,23.3,0.9902755267423015,-0.014098109330688354,0.9503179393443983,0.02213107239294252,0.9764551217793213,0.010347712244517526,7599]
["High","A6NHQ2","rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 [OS=Homo sapiens]",10,4,13,1,334,34.8,10.35,37.65,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","FBLL1","ENSG00000188573","","","",23,22.4,24.8,24.6,22.7,26.4,0.9525101763907736,-0.07019358879050866,0.4165491233204684,0.3803337752199491,0.6411227192758165,0.1930588328787179,5073]
["High","A6NHR9-1","structural maintenance of chromosomes flexible hinge domain-containing protein 1 [OS=Homo sapiens]",19,31,63,31,2005,226.2,7.3,124.61,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMCHD1","ENSG00000101596","","","",2831.2,2771,2797.7,2816.1,2908,2852.8,0.9793631731744569,-0.03008414723509536,0.13791717211110846,0.8603816563129526,0.3454787551631488,0.4615786539311571,3117]
["Medium","A6NHX0","Cytosolic arginine sensor for mTORC1 subunit 2 [OS=Homo sapiens]",6,1,2,1,329,36,5.16,0,"other biological processes","cytosol","other molecular function","CASTOR2","ENSG00000274070","","Amino acids regulate mTORC1","mTOR signaling pathway",16.3,18.5,18.3,15.8,14.1,21,1.0432220039292732,0.06104620472845852,0.7546798261876634,0.1222372592473439,0.8711620465513418,0.059901053514412626,6764]
["Medium","A6NHY2","ankyrin repeat and death domain-containing protein 1B [OS=Homo sapiens]",1,1,1,1,528,59.1,8.35,2.29,"signal transduction","","","ANKDD1B","ENSG00000189045","","","",147.6,236.5,197.2,230.6,219.8,166.3,0.9425976974217608,-0.08528593774613205,0.734978569880941,0.13372532366156914,0.8603767126882139,0.06531135291948277,6670]
["High","A6NI28","Rho GTPase-activating protein 42 [OS=Homo sapiens]",2,2,3,1,874,98.5,7.99,7.83,"signal transduction;other biological processes","","enzyme regulator activity","ARHGAP42","ENSG00000165895","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",62.9,67.4,65.3,68.6,60.9,74.4,0.9592937714565963,-0.059955405064362845,0.5387155025396894,0.26864052664344706,0.7322929393854273,0.13531515321905563,5744]
["High","A6NIH7","Protein unc-119 homolog B [OS=Homo sapiens]",69,10,32,9,251,28.1,5.68,106.26,"cell organization and biogenesis;transport;developmental processes","cytosol;other cell component","other molecular function","UNC119B","ENSG00000175970","","Trafficking of myristoylated proteins to the cilium","",1004.5,926.9,945.5,873.3,874.4,864,1.101543056246889,0.13952588706771982,0.020083292727469705,1.697165081560076,0.11843681995172467,0.9265132620051217,1324]
["High","A6NJ78","Probable methyltransferase-like protein 15 [OS=Homo sapiens]",7,2,3,2,407,46.1,8.62,8.59,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","METTL15","ENSG00000169519","","","",41.9,41.6,37.3,41.9,38.9,39.7,1.0024896265560166,3.587308207754927E-3,0.9568165289669761,0.019171330871189766,0.9799086382704814,0.008814413842824338,7624]
["High","A6NK58","Putative lipoyltransferase 2, mitochondrial [OS=Homo sapiens]",10,2,2,2,231,25.2,8.27,0,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","LIPT2","ENSG00000175536","","Glyoxylate metabolism and glycine degradation","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors",34,35.6,28.9,38.3,35.6,38.1,0.8794642857142857,-0.18530310260122787,0.11014039894653846,0.9580533547662449,0.2992262473815492,0.5240003139058164,2874]
["High","A6NKD9","Coiled-coil domain-containing protein 85C [OS=Homo sapiens]",8,3,3,3,419,45.2,6.96,1.63,"developmental processes","other cell component","","CCDC85C","ENSG00000205476","","","",56.8,36,31.2,36.1,30.1,29.8,1.2916666666666667,0.3692338096657191,0.3144329882961647,0.5024718968456195,0.5517062410374053,0.25829210316791573,4450]
["High","A6NKF1","SAC3 domain-containing protein 1 [OS=Homo sapiens]",7,2,5,2,404,43.5,8.69,17.18,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","","SAC3D1","","","","",187.3,153.2,154.3,162.5,160.7,152.5,1.0401513558965736,0.0567934750139154,0.6124058804408252,0.21296064777335158,0.7832375289896746,0.10610651139561747,6105]
["Medium","A6NMB9","Putative fidgetin-like protein 2 [OS=Homo sapiens]",1,1,1,1,653,66.6,6.73,1.79,"cell organization and biogenesis","nucleus","other molecular function","FIGNL2","ENSG00000261308","","","",30.1,25.6,22.9,34.6,36.3,30.8,0.7728613569321534,-0.37171846159889355,0.04414881995422425,1.3550809001094666,0.18076244688127055,0.7428917884968368,1907]
["High","A6ZKI3","Retrotransposon Gag-like protein 8B [OS=Homo sapiens]",29,3,6,3,113,13.2,5.07,9.43,"","","","RTL8C","ENSG00000134590","","","",76.5,81.2,72.2,66.4,76.8,65.7,1.1005265677357587,0.13819397365107178,0.1893230380395139,0.722796535087149,0.4118791532495192,0.38523018876175347,3589]
["High","A7E2V4","Zinc finger SWIM domain-containing protein 8 [OS=Homo sapiens]",2,2,2,2,1837,197.2,6.8,3.1,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","ZSWIM8","ENSG00000214655","","Regulation of expression of SLITs and ROBOs","",52.3,53.8,48.1,55.7,57.9,55.5,0.911886457717327,-0.133073894494949,0.05672224166557913,1.2462466141480892,0.209700408581838,0.6784007233512285,2112]
["High","A8CG34-1","Nuclear envelope pore membrane protein POM 121C [OS=Homo sapiens]",5,6,12,1,1229,125,10.37,18.15,"","","","","","","","",106.2,112.4,125.1,106.6,91.1,101.4,1.149114008692745,0.20052194125294512,0.10748318754563796,0.9686594625128352,0.2950874572279681,0.5300492499119285,2844]
["Low","A8K2U0","Alpha-2-macroglobulin-like protein 1 [OS=Homo sapiens]",0,1,1,1,1454,161,5.73,0,"other biological processes","non-structural extracellular","enzyme regulator activity;other molecular function","A2ML1","ENSG00000166535","","","",82.1,79.4,72.9,59.4,81.7,72.8,1.0958391771856009,0.13203608725720375,0.3862401070234806,0.41314263124383477,0.6163422758306432,0.21017804234513754,4893]
["High","A8MQ14","Zinc finger protein 850 [OS=Homo sapiens]",8,4,5,4,1090,125.4,8.7,12.46,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF850","ENSG00000267041","","","Herpes simplex virus 1 infection",348.2,368.5,350.4,385.4,376.8,402.6,0.9161229395604394,-0.12638688041568993,0.030646577240903968,1.5136180225613627,0.14844198207008572,0.8284432553717993,1612]
["Medium","A8MW92","PHD finger protein 20-like protein 1 [OS=Homo sapiens]",1,1,1,1,1017,114.9,6.83,2.1,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF20L1","ENSG00000129292","","","",81.9,95.1,77.2,111.4,100,86.7,0.8527339818852734,-0.22983234498620997,0.1764194881791845,0.7534534422132768,0.3951472644013404,0.4032410203286158,3486]
["High","A9UHW6","MIF4G domain-containing protein [OS=Homo sapiens]",18,4,5,4,222,25.4,5.33,10.69,"other biological processes","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","MIF4GD","ENSG00000125457","","","",122.6,124.4,142.2,138.3,125.2,140.4,0.9636048526863085,-0.05348643592197509,0.5666791680450534,0.24666275236533786,0.7531286713354514,0.12313081865047631,5875]
["Medium","B0YJ81","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 [OS=Homo sapiens]",4,1,1,1,288,32.4,9.04,2.63,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","HACD1","ENSG00000165996","","Synthesis of very long-chain fatty acyl-CoAs","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism",42,34,35.8,31,33.8,37.3,1.0950048971596473,0.13093732196538851,0.3463114940841695,0.46053309397035097,0.5830099495060792,0.23432403361368412,4638]
["High","B2RTY4","unconventional myosin-IXa [OS=Homo sapiens]",4,9,9,8,2548,292.5,8.88,12.24,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","MYO9A","ENSG00000066933","","RHOA GTPase cycle; RHOB GTPase cycle; RHOV GTPase cycle","",325.5,324.9,324.2,299.2,278.4,285.3,1.1294472128867772,0.17561684489116466,3.7080309025844037E-3,2.4308566551192454,0.052545018670379355,1.279468449312395,551]
["High","L0R6Q1","SLC35A4 upstream open reading frame protein [OS=Homo sapiens]",22,1,1,1,103,11.1,8.1,3.21,"stress response","other membranes","","SLC35A4","ENSG00000176087","","","",23.3,17.6,16.6,16.7,21.4,17.9,1.0267857142857144,0.03813512888677129,0.8523048823587632,0.06940502372988051,0.9281445636620953,0.032384374739045235,7170]
["High","O00115","Deoxyribonuclease-2-alpha [OS=Homo sapiens]",4,2,5,2,360,39.6,8.05,8.52,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","other cytoplasmic organelle","nucleic acid binding activity;other molecular function","DNASE2","ENSG00000105612","","Lysosome Vesicle Biogenesis","Lysosome",557.5,583.1,593.9,638,611.3,621.6,0.9270939120209525,-0.10921260766063484,0.02682758104493566,1.571418484472929,0.1378090478939853,0.8607222677590664,1520]
["High","O00116","Alkyldihydroxyacetonephosphate synthase, peroxisomal [OS=Homo sapiens]",39,18,47,18,658,72.9,7.34,100.26,"other metabolic processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","AGPS","ENSG00000018510","Triacylglyceride synthesis","Plasmalogen biosynthesis; TYSND1 cleaves peroxisomal proteins","Ether lipid metabolism; Metabolic pathways; Peroxisome",1360.9,1414.2,1436.8,1369.3,1490.7,1442.4,{"$f":"AVERAGE(T66:V66)/AVERAGE(W66:Y66)","v":0.9789652287095577},{"$f":"LOG(Z66,2)","v":-0.030670476385414716},{"$f":"TTEST(T66:V66,W66:Y66,2,2)","v":0.5109019419671845},{"$f":"-LOG10(AB66)","v":0.29166244653670426},{"$f":"AB66*7808/AF66","v":0.7140007808984744},{"$f":"-LOG10(AD66)","v":0.1463013132382333},5587]
["High","O00139-2","Isoform 2 of Kinesin-like protein KIF2A [OS=Homo sapiens]",40,19,66,16,660,75,6.4,111.99,"","","","KIF2A","","","","",1881,1857.9,1909.2,1959.8,1793.9,1872.5,1.0038925029327077,5.6047934033331675E-3,0.8913212817207598,0.04996572387771654,0.9497047717898052,0.022411379878875103,7328]
["High","O00148","ATP-dependent RNA helicase DDX39A [OS=Homo sapiens]",49,19,142,7,427,49.1,5.68,236.83,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","other molecular function","DDX39A","ENSG00000123136","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",1622.1,1674.3,1740.4,1771.5,2006.7,1870.1,0.8917373368978276,-0.165309271018286,0.05571986429877235,1.2539899499359084,0.20746814518112278,0.6830485757426168,2097]
["High","O00151","PDZ and LIM domain protein 1 [OS=Homo sapiens]",33,10,31,9,329,36,7.02,72.73,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PDLIM1","ENSG00000107438","","","",1461.3,1360.6,1313.8,1644.4,1293.6,1403.2,0.9526628581958906,-0.06996235175371576,0.5751008765279418,0.24025597048094255,0.7585114263395558,0.12003787254522687,5920]
["High","O00154","cytosolic acyl coenzyme A thioester hydrolase [OS=Homo sapiens]",47,16,63,16,380,41.8,8.54,116.69,"other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","ACOT7","ENSG00000097021","","Mitochondrial Fatty Acid Beta-Oxidation","Fatty acid elongation; Biosynthesis of unsaturated fatty acids",2302.1,2230.9,2201.2,2074.2,2321.5,2140.6,1.0302770680660314,0.0430323674782911,0.4545266419845578,0.34244065561522935,0.6718939834561581,0.17269924782749915,5282]
["High","O00159-3","Isoform 3 of Unconventional myosin-Ic [OS=Homo sapiens]",19,17,24,17,1044,119.6,9.45,43.63,"","","","MYO1C","","","","",1200.2,1288.9,1239.4,1322.1,1346.8,1310.5,0.9369502940141733,-0.0939555811345691,0.03963744159192836,1.4018943849225187,0.16902738610036955,0.7720429245655798,1831]
["High","O00161","Synaptosomal-associated protein 23 [OS=Homo sapiens]",67,13,35,13,211,23.3,5.01,82.87,"cell-cell signaling;cell organization and biogenesis;stress response;transport","plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP23","ENSG00000092531","Insulin signaling","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding","SNARE interactions in vesicular transport; Platelet activation",1609.3,1536.7,1521.8,1392.4,1305.7,1306.3,1.165667765457996,0.2211566552401707,0.004995977747090116,2.3013795047129326,0.05964616857688016,1.2244174483785644,654]
["High","O00165","HCLS1-associated protein X-1 [OS=Homo sapiens]",28,6,14,6,279,31.6,4.92,39.84,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HAX1","ENSG00000143575","","","",648.4,609,611.5,746.6,682.2,698.6,0.8784901758014478,-0.18690194229262058,0.020416179411001788,1.6900255264980328,0.11958704339167438,0.9223158712532566,1333]
["High","O00170","AH receptor-interacting protein [OS=Homo sapiens]",32,8,21,8,330,37.6,6.29,43.43,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","AIP","ENSG00000110711","Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway","Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Cushing syndrome; Chemical carcinogenesis",742.9,671.2,642,851.4,767.7,742,0.8708229215196307,-0.19954871270864238,0.08484323080393351,1.071382802041321,0.26173684161087035,0.5821351425409397,2531]
["High","O00178","GTP-binding protein 1 [OS=Homo sapiens]",29,15,40,15,669,72.4,8.34,104.63,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;other cytoplasmic organelle","nucleic acid binding activity;other molecular function","GTPBP1","ENSG00000100226","","","",1323.1,1354.1,1324.8,1233.9,1408.1,1317.5,1.0107336784947596,0.015402906904399308,0.7961004114089071,0.09903215164604093,0.8947678152124293,0.04828964586176083,6947]
["High","O00180","potassium channel subfamily K member 1 [OS=Homo sapiens]",12,2,2,2,336,38.1,6.37,7.92,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","KCNK1","ENSG00000135750","","Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK); Phase 4 - resting membrane potential","",36.9,31.1,42.9,43.4,43.1,32.7,0.9303691275167786,-0.10412487030045155,0.6022610458380153,0.2202152260286535,0.7766233271516472,0.10978956884908916,6055]
["High","O00186","syntaxin-binding protein 3 [OS=Homo sapiens]",23,13,30,13,592,67.7,7.8,52.2,"cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STXBP3","ENSG00000116266","Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation","",1115.9,1076,1093,1077.7,1072.8,1093.8,1.012514255771661,0.017942220675083023,0.3627383857601521,0.4404064840067711,0.5981544490000565,0.22318666268742793,4735]
["High","O00189","AP-4 complex subunit mu-1 [OS=Homo sapiens]",8,3,4,3,453,49.9,7.2,3.41,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","AP4M1","ENSG00000221838","","Lysosome Vesicle Biogenesis","Lysosome",240.1,250.2,298.5,264.4,294.3,262.5,0.9605455431076473,-0.058074075730690566,0.6302986773478152,0.20045360422001093,0.7971124186478363,0.09848042470745205,6174]
["High","O00192","armadillo repeat protein deleted in velo-cardio-facial syndrome [OS=Homo sapiens]",19,13,19,13,962,104.6,6.81,45.39,"cell adhesion;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","ARVCF","ENSG00000099889","22q11.2 copy number variation syndrome","","",788,790.2,759.1,684.6,618.1,656.2,1.1931696360202153,0.25479916930902574,0.004370987152338146,2.3594204700321613,0.05688111280909374,1.2450319157571696,600]
["High","O00193","Small acidic protein [OS=Homo sapiens]",31,7,43,7,183,20.3,4.72,97.37,"","","","SMAP","ENSG00000110696","","","",1602.9,1616,1541.4,1795.8,1630.7,1591.8,0.9485881673076539,-0.07614622254101584,0.26633931451720444,0.5745647223419046,0.5020708275592304,0.2992350122407029,4142]
["High","O00203-1","AP-3 complex subunit beta-1 [OS=Homo sapiens]",23,23,56,18,1094,121.2,6.04,99.11,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","AP3B1","ENSG00000132842","","Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions","Lysosome",2599.9,2600.8,2542.8,2462.5,2727,2615,0.9921839964123264,-0.011320407645458302,0.8096200278806323,0.09171875706250354,0.9033314057862214,0.04415289055075574,6998]
["High","O00213","amyloid-beta A4 precursor protein-binding family B member 1 [OS=Homo sapiens]",9,5,6,5,710,77.2,5.06,9.96,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","APBB1","ENSG00000166313","Alzheimer's disease and miRNA effects; Alzheimer's disease","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks","Alzheimer disease",244.9,248.8,259.8,331.8,276.1,281.6,0.8471051152332769,-0.23938709366933622,0.06815733999684609,1.1664873672911509,0.22938470288593718,0.6394355475234151,2320]
["High","O00214-1","Galectin-8 [OS=Homo sapiens]",7,2,2,2,317,35.8,8.25,3.31,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","LGALS8","ENSG00000116977","","","",32.3,35.2,35,29.3,48.8,38.4,0.8798283261802574,-0.18470604514883437,0.459682018255206,0.3375424845578908,0.6759316758072784,0.17009720098072448,5310]
["High","O00217","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [OS=Homo sapiens]",16,3,5,3,210,23.7,6.34,9.73,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS8","ENSG00000110717","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",148.7,130.7,116,141.8,118.3,103,1.088956210410355,0.12294594092900031,0.5051073651399562,0.29661629884793334,0.7102247986696881,0.14860416766186452,5553]
["High","O00220","Tumor necrosis factor receptor superfamily member 10A [OS=Homo sapiens]",7,3,5,3,468,50.1,7.03,2.26,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TNFRSF10A","ENSG00000104689","Apoptosis modulation and signaling","Cell surface interactions at the vascular wall; Regulation by c-FLIP; RIPK1-mediated regulated necrosis; CASP8 activity is inhibited; TP53 Regulates Transcription of Death Receptors and Ligands; Dimerization of procaspase-8; TRAIL  signaling","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; p53 signaling pathway; Apoptosis; Necroptosis; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Salmonella infection; Influenza A; Lipid and atherosclerosis",140.8,142.4,135,167.5,164.6,155.6,0.8574943612876768,-0.22180091044628855,0.005407368616232278,2.2670140238885965,0.06208931493462004,1.2069831319361977,680]
["High","O00221","NF-kappa-B inhibitor epsilon [OS=Homo sapiens]",9,3,8,3,500,52.8,6.68,10.8,"other biological processes","cytosol;nucleus;other cell component","","NFKBIE","ENSG00000146232","TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19","Activation of NF-kappaB in B cells","Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Epstein-Barr virus infection; PD-L1 expression and PD-1 checkpoint pathway in cancer",136.5,166.4,161.9,164.8,125.5,143.7,1.0709677419354837,0.098915026072687,0.5229241593613142,0.28156129308155675,0.7226534223527683,0.1410699362423599,5650]
["High","O00231","26S proteasome non-ATPase regulatory subunit 11 [OS=Homo sapiens]",60,23,74,23,422,47.4,6.48,164.89,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD11","ENSG00000108671","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling pathway","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",3586.9,3606.7,3556,3495.4,3543,3551.2,1.015109163707789,0.02163488156948826,0.07952401793328695,1.0995016854244701,0.25199818669768853,0.5986025842582227,2464]
["High","O00232-1","26s proteasome non-atpase regulatory subunit 12 [OS=Homo sapiens]",51,20,144,20,456,52.9,7.65,244.33,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","","PSMD12","ENSCANG00000030312; ENSCATG00000032968; ENSCSAG00000004164; ENSG00000197170; ENSMFAG00000032701; ENSMLEG00000034943; ENSMMUG00000002132; ENSMNEG00000032475; ENSNLEG00000001265; ENSPANG00000020562; ENSPPYG00000008565; ENSRROG00000042400","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease","Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",4073.5,4297.7,4282,3854.9,4510.4,4193.6,1.0075086193854557,0.010792181275783606,0.8842100546060958,0.053444550914969774,0.9453528832485822,0.02440604689778444,7303]
["High","O00233-1","26S proteasome non-ATPase regulatory subunit 9 [OS=Homo sapiens]",33,7,19,7,223,24.7,6.95,43.16,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMD9","ENSG00000110801","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",727.9,698.2,640.1,734.2,585.2,563.8,1.0971750212404416,0.13379368265541453,0.3630019242893861,0.4400910727433726,0.5982100094663416,0.2231463244714835,4738]
["Medium","O00244","Copper transport protein ATOX1 [OS=Homo sapiens]",12,1,3,1,68,7.4,7.24,6.45,"stress response;transport;other biological processes","cytosol","other molecular function","ATOX1","ENSG00000177556","Copper homeostasis","Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface","Mineral absorption",170.4,182.6,151.5,163.2,177.2,150.1,1.0285423037716614,0.04060113288711835,0.7163110401983576,0.14489835519307956,0.849735126385411,0.07071642849279895,6582]
["High","O00255-2","Isoform 2 of Menin [OS=Homo sapiens]",26,12,20,12,610,67.5,6.55,48.24,"","","","MEN1","","","","",714.6,741.7,740.3,651.7,655.2,683.1,1.1038190954773872,0.14250374870732851,0.006576682869127021,2.1819930995287296,0.06810442949886443,1.1668246407398684,754]
["High","O00258-1","Tail-anchored protein insertion receptor WRB [OS=Homo sapiens]",13,2,2,2,174,19.8,9.67,2.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus","","GET1; WRB","ENSANAG00000014374; ENSCANG00000035340; ENSCATG00000041953; ENSCCAG00000026562; ENSCSAG00000008355; ENSG00000182093; ENSMLEG00000038301; ENSMNEG00000036276; ENSNLEG00000033928; ENSPANG00000032093; ENSPPAG00000034665; ENSPPYG00000011427; ENSPTRG00000013915; ENSSBOG00000020756","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",22.3,25.5,25.5,21.8,22.1,26.9,1.0353107344632766,0.050063838050814095,0.6935561618718308,0.15891836544367366,0.8350480357587132,0.07828854120513709,6485]
["High","O00264","Membrane-associated progesterone receptor component 1 [OS=Homo sapiens]",69,19,142,17,195,21.7,4.7,283.11,"other metabolic processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PGRMC1","ENSG00000101856","","Neutrophil degranulation","",5978.1,5532,5221.8,5674.1,5034.1,5108.3,1.0578762684538299,0.08117089651910861,0.3642805444060499,0.43856402305598724,0.5991789531751501,0.22244345011571184,4747]
["High","O00267","Transcription elongation factor Spt5 [OS=Homo sapiens]",34,28,82,28,1087,120.9,5.06,189.56,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SUPT5H","ENSG00000196235","Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","",2943.7,3000.9,2945.5,3172.1,3275.1,3277.1,0.9142149049288897,-0.1293947547337503,2.1315535872852135E-3,2.6713037447106194,0.04119596636020532,1.3851453051625888,404]
["High","O00268","Transcription initiation factor TFIID subunit 4 [OS=Homo sapiens]",10,7,11,7,1085,110,9.94,32.34,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","TAF4","ENSG00000130699","","RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors; Huntington disease",345.2,366.1,358.2,348.2,320.8,347.9,1.051725833415282,0.0727586682017921,0.18419966260148193,0.7347111696356345,0.40524963809308845,0.392277364324592,3549]
["High","O00273-1","DNA fragmentation factor subunit alpha [OS=Homo sapiens]",56,13,36,4,331,36.5,4.79,78.92,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DFFA","ENSG00000160049","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis","Apoptosis induced DNA fragmentation","Apoptosis",790.1,720.6,739.3,744.4,711.5,761.7,1.0146103896103893,0.02092583885454758,0.6931759736705148,0.15915649887668679,0.8351053853447583,0.07825871567120243,6481]
["High","O00291","Huntingtin-interacting protein 1 [OS=Homo sapiens]",38,32,79,31,1037,116.1,5.3,156.45,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HIP1","ENSG00000127946","","Clathrin-mediated endocytosis; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","Huntington disease; Pathways of neurodegeneration",3527.6,3703.8,3618.8,3797.6,3702.9,3812.3,0.9591082667420976,-0.06023441512291583,0.065805259790086,1.1817393920012975,0.22456620124169208,0.6486556074636488,2288]
["High","O00299","chloride intracellular channel protein 1 [OS=Homo sapiens]",87,18,146,17,241,26.9,5.17,373.46,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion;nucleus;other cell component","transporter activity","CLIC1","ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685","VEGFA-VEGFR2 signaling pathway","","",5646,5521.1,5570.7,5656.5,5913.6,5562.1,0.9769790219586508,-0.033600510422616046,0.30231514783061436,0.5195400914777191,0.5395375255454713,0.26797834417741573,4375]
["Medium","O00300","Tumor necrosis factor receptor superfamily member 11B [OS=Homo sapiens]",2,1,1,1,401,46,8.29,2.13,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","TNFRSF11B","ENSG00000164761","Osteoclast signaling; RANKL/RANK signaling pathway; Ectoderm differentiation; Vitamin D receptor pathway; Osteoblast signaling; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Overlap between signal transduction pathways contributing to LMNA laminopathies; Monoamine transport","TNFs bind their physiological receptors","Cytokine-cytokine receptor interaction; Osteoclast differentiation",80.5,88.9,90.3,103.7,118.2,107.3,0.7888821385176185,-0.3421183217432183,0.0121591252901964,1.9150976664534738,0.09059012429947852,1.0429191444425463,1048]
["High","O00303","Eukaryotic translation initiation factor 3 subunit F [OS=Homo sapiens]",42,11,55,11,357,37.5,5.45,110.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3F","ENSG00000175390","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",2228.1,2134.1,2185,2060.7,2239.1,2138.9,1.0168512277323063,0.02410861851380592,0.5688810577522352,0.2449785268591194,0.7546420827267163,0.12225897996407617,5886]
["High","O00308","NEDD4-like E3 ubiquitin-protein ligase WWP2 [OS=Homo sapiens]",14,10,14,9,870,98.9,7.12,23.19,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","WWP2","ENSG00000198373","","RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle","Ubiquitin mediated proteolysis",414.1,434.8,427.4,474.3,481.6,440.9,0.9137313860252004,-0.13015798322054975,0.04472012455113236,1.3494969955555738,0.18224150965304878,0.739352695639464,1916]
["High","O00311-1","Cell division cycle 7-related protein kinase [OS=Homo sapiens]",5,2,5,2,574,63.8,8.73,10.07,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CDC7","ENSG00000097046","Cell cycle; Retinoblastoma gene in cancer; DNA replication","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Transcriptional Regulation by E2F6","Cell cycle",40.7,33.5,40.1,46.7,52.5,46.3,0.7855670103092783,-0.34819374958116805,0.02717204514014278,1.5658776725996884,0.13930356431663482,0.8560377712770956,1523]
["High","O00330-1","Pyruvate dehydrogenase protein X component, mitochondrial [OS=Homo sapiens]",24,11,21,11,501,54.1,8.66,44.04,"other metabolic processes","mitochondrion;other cell component","other molecular function","PDHX","ENSG00000110435","Amino acid metabolism","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Metabolic pathways",877.8,915,905.1,868.8,867.3,901.7,1.0227841382970657,0.03250169203400043,0.27367572571560644,0.5627637216080787,0.5093826141567235,0.2929558821141624,4195]
["Low","O00339-1","Matrilin-2 [OS=Homo sapiens]",1,1,2,1,956,106.8,6.27,3.59,"","non-structural extracellular;extracellular matrix","extracellular structural activity;other molecular function","MATN2","ENSG00000132561","","","",149.6,163.3,173.9,164.7,171.6,148.3,1.0045398266611638,6.534763262381893E-3,0.9442840060093032,0.024897366197274666,0.9738435502470796,0.011510807722885406,7571]
["High","O00391","Sulfhydryl oxidase 1 [OS=Homo sapiens]",3,2,2,2,747,82.5,8.92,3.63,"cell organization and biogenesis;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","QSOX1","ENSG00000116260","","Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",182.6,164.7,183.9,134.4,154.5,138.7,1.2422825070159025,0.3129932936264339,0.016556969482870873,1.7810191516881668,0.10710589703583742,0.9701866171268807,1207]
["High","O00399","Dynactin subunit 6 [OS=Homo sapiens]",22,4,8,4,190,20.7,6.32,12.06,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","DCTN6","ENSG00000104671","","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","Vasopressin-regulated water reabsorption; Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection",434.1,410.1,390.3,470.6,444.7,457.9,0.8989950480629189,-0.15361492592711218,0.03471941818991132,1.4594275611173237,0.15697117384298062,0.8041800940261472,1727]
["High","O00400","Acetyl-coenzyme A transporter 1 [OS=Homo sapiens]",12,6,10,6,549,60.9,7.33,16.81,"transport;signal transduction","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC33A1","ENSG00000169359","Ganglio sphingolipid metabolism","Transport of vitamins, nucleosides, and related molecules; Defective SLC33A1 causes spastic paraplegia 42 (SPG42)","Glycosphingolipid biosynthesis; Metabolic pathways",409.7,411.7,389.7,382.2,399.6,376.2,1.0458549222797928,0.06468273932506736,0.149203165340811,0.8262219632208202,0.36269561487579455,0.44045769516882816,3212]
["High","O00401","Neural Wiskott-Aldrich syndrome protein [OS=Homo sapiens]",30,10,24,10,505,54.8,7.93,39.06,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity","WASL","ENSG00000106299","Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 signaling pathway","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle; RHOV GTPase cycle; NOSTRIN mediated eNOS trafficking; Nephrin family interactions; EPHB-mediated forward signaling; DCC mediated attractive signaling","Endocytosis; Adherens junction; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",727.6,780.2,783.9,892.9,804.1,819,0.9108505564387919,-0.1347137249111725,0.08568218743397853,1.067109454660096,0.263077671838185,0.5799160101771695,2543]
["High","O00410","Importin-5 [OS=Homo sapiens]",64,47,286,44,1097,123.6,4.94,616.8,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","IPO5","ENSG00000065150","","vRNP Assembly","Nucleocytoplasmic transport",8722.3,8776.9,8747.3,8759.2,8957.6,8917.8,0.9854287280454744,-0.021176563967321323,0.10772968630445844,0.9676646047643178,0.29534880290211074,0.5296647850705012,2848]
["High","O00411","DNA-directed RNA polymerase, mitochondrial [OS=Homo sapiens]",17,16,27,16,1230,138.5,8.98,50.34,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","POLRMT","ENSG00000099821","Mitochondrial gene expression","Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis","",599.7,615.5,621.8,582.7,660.3,615.7,0.988325173508366,-0.016942307100917417,0.7729035759583901,0.11187468336659706,0.8809972439537387,0.05502545020038723,6850]
["High","O00418","Eukaryotic elongation factor 2 kinase [OS=Homo sapiens]",10,7,10,7,725,82.1,5.33,18.04,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;kinase activity;other molecular function","EEF2K","ENSG00000103319","Translation factors; AMP-activated protein kinase (AMPK) signaling; BDNF-TrkB signaling","mTORC1-mediated signalling","AMPK signaling pathway; Oxytocin signaling pathway",387.2,363.7,370.2,368.9,357.8,368.5,1.0236486486486487,0.03372061784400119,0.3354889271656664,0.4743218091766815,0.572567769029404,0.24217310292051317,4575]
["High","O00422","Histone deacetylase complex subunit SAP18 [OS=Homo sapiens]",60,10,53,10,153,17.6,9.35,91.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SAP18","ENSG00000150459","Hedgehog signaling pathway","Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression","Nucleocytoplasmic transport; mRNA surveillance pathway",4352.3,3790.5,3894.7,3877.3,3810.1,3792.1,1.048608388867111,0.06847599257339938,0.3464797820628704,0.4603221024510453,0.5827906373000629,0.23448743391230883,4642]
["High","O00423-1","Echinoderm microtubule-associated protein-like 1 [OS=Homo sapiens]",5,4,7,4,815,89.8,7.06,15.94,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","EML1","ENSG00000066629","","","",197.4,183.9,203.8,184.5,206.8,199.1,0.9910230352303524,-0.013009503241126387,0.8504209029205145,0.0703660736123848,0.9273863701122036,0.03273929126160494,7160]
["High","O00425","Insulin-like growth factor 2 mRNA-binding protein 3 [OS=Homo sapiens]",56,30,200,24,579,63.7,8.87,408.36,"protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP3","ENSG00000136231","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",8062.8,8168.4,8236.1,8854.6,9176.2,9095.9,0.901963747894141,-0.14885864564659188,1.2436317462936341E-3,2.9053082002150705,0.032916192118849816,1.4825904115345983,295]
["High","O00429","Dynamin-1-like protein [OS=Homo sapiens]",73,46,289,1,736,81.8,6.81,653.37,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","DNM1L","ENSG00000087470","Synaptic vesicle pathway; CAMKK2 pathway","Apoptotic execution phase","Necroptosis; NOD-like receptor signaling pathway; TNF signaling pathway",95.7,87,90.6,88.2,97.8,104.9,0.939498109315916,-0.09003783657709961,0.3429077016338547,0.4648227606140644,0.5792780905143093,0.23711289709851946,4622]
["High","O00429-6","Isoform 6 of Dynamin-1-like protein [OS=Homo sapiens]",71,46,287,0,749,83.3,7.08,646.88,"","","","DNM1L","","","","",10779,10918.1,10933.6,10282.3,10316.3,10517.7,1.0486690255589513,0.06855941525657575,0.004648364776164334,2.332699798419104,0.057885856734116614,1.237427534591185,627]
["High","O00429-8","Isoform 8 of Dynamin-1-like protein [OS=Homo sapiens]",72,46,285,1,738,82,6.96,642.25,"","","","DNM1L","","","","",191.4,201.7,210.6,172.6,214.5,194.9,1.0372852233676977,0.05281264801707848,0.6158055910449464,0.21055637235236385,0.7856552377253172,0.10476798983928964,6120]
["High","O00442","RNA 3'-terminal phosphate cyclase [OS=Homo sapiens]",44,14,50,14,366,39.3,7.85,106.23,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RTCA","ENSG00000137996","","","",1685.2,1715.1,1705.2,1698.9,1737.8,1758,0.9828286522802087,-0.02498817786695246,0.20097583708899913,0.6968561537721193,0.42595530292912737,0.3706359706382952,3684]
["High","O00443","phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [OS=Homo sapiens]",15,23,41,23,1686,190.6,8.02,76.67,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2A","ENSG00000011405","Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection",1901.5,1929.5,1935.3,2047.1,1971.5,1967.8,0.9632333288787921,-0.054042783171522585,0.058015631211663414,1.2364549782583412,0.21137939734048902,0.6749373446415345,2143]
["High","O00458","Interferon-related developmental regulator 1 [OS=Homo sapiens]",11,3,3,3,451,50.2,7.18,9.27,"other biological processes","nucleus","","IFRD1","ENSG00000006652","Hypertrophy model","","",29.4,25.3,25.8,39.4,32.3,33.3,0.7666666666666668,-0.3833286395515053,0.033502712512301074,1.474920029338253,0.15478649662487975,0.810266929293291,1690]
["High","O00459","Phosphatidylinositol 3-kinase regulatory subunit beta [OS=Homo sapiens]",16,7,14,7,728,81.5,6.43,30.92,"other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R2","ENSG00000105647","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway","Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOU GTPase cycle; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",383.2,382.2,391.7,396.6,400.4,406.5,0.96144578313253,-0.05672259001194144,0.020688601581101352,1.684268863908277,0.12054970234719355,0.9188338576144492,1340]
["High","O00461","Golgi integral membrane protein 4 [OS=Homo sapiens]",32,17,34,17,696,81.8,4.77,79.63,"","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","GOLIM4","ENSG00000173905","","Intra-Golgi traffic","",1218.7,1237,1226.4,1261.9,1231.9,1193.5,0.9985897540205568,-0.002035990842594863,0.9366594329180475,0.02841828882444711,0.9704666735966182,0.01301937395063269,7536]
["High","O00462","Beta-mannosidase [OS=Homo sapiens]",8,7,11,6,879,100.8,5.52,16.56,"protein metabolism;other metabolic processes","plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","MANBA","ENSG00000109323","","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","Other glycan degradation; Lysosome",317.3,333.2,285.5,260.6,279.6,292.4,1.1241892865721834,0.1688849713305485,0.10936979783182323,0.9611025906705524,0.29817017509457955,0.5255357996477349,2864]
["High","O00463","TNF receptor-associated factor 5 [OS=Homo sapiens]",4,2,4,2,557,64.4,7.43,1.67,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","signal transduction activity or receptor binding;other molecular function","TRAF5","ENSG00000082512","RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Small cell lung cancer; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling","","NF-kappa B signaling pathway; Necroptosis; NOD-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Shigellosis; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Small cell lung cancer",29.6,24.9,28.7,30.9,29.2,26.8,0.9574223245109322,-0.06277264867330784,0.5451516324334846,0.26348268309976686,0.7369362787466496,0.13257006300271418,5776]
["High","O00468","Agrin [OS=Homo sapiens]",18,26,37,26,2067,217.1,6.39,78.62,"","","","","","","","",1293.6,1307.9,1295.9,1385.7,1285.8,1387.8,0.9601162762052571,-0.058718958901044255,0.18709052726123312,0.727948201074666,0.40953261476190306,0.38771150575438457,3567]
["High","O00469-1","procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [OS=Homo sapiens]",13,7,15,7,737,84.6,6.71,30.91,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","PLOD2","ENSG00000152952","Clear cell renal cell carcinoma pathways; Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","Lysine degradation; Metabolic pathways",723.7,673.3,762.5,638.9,696.8,662.7,1.0806144915932747,0.11185193448642712,0.15627472419966298,0.8061112588860144,0.37155695692782237,0.4299746026747822,3284]
["High","O00471","Exocyst complex component 5 [OS=Homo sapiens]",20,15,29,15,708,81.8,6.71,45.03,"cell organization and biogenesis;transport;other biological processes","cytosol;other cell component","other molecular function","EXOC5","ENSG00000070367","Ciliary landscape","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium","Salmonella infection",1398.7,1390.1,1347.6,1355.9,1351.7,1366,1.0154163393558522,0.02207138018706751,0.2697932971981944,0.5689688442341583,0.5054093245017998,0.296356749866991,4168]
["High","O00483","Cytochrome c oxidase subunit NDUFA4 [OS=Homo sapiens]",56,5,13,5,81,9.4,9.38,22.67,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NDUFA4","ENSG00000189043","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; Oxidative phosphorylation","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",703.7,641.5,618.2,518.8,593.4,600.4,1.1464440032698822,0.19716588987049957,0.08388173673311454,1.076332586244368,0.25990023825879294,0.5851933223672767,2520]
["High","O00487","26S proteasome non-ATPase regulatory subunit 14 [OS=Homo sapiens]",41,12,33,12,310,34.6,6.52,69.71,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMD14","ENSG00000115233","Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Metalloprotease DUBs","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",1811.5,1742.2,1736.6,1671.6,1828.8,1808.4,0.9965152200120555,-0.005036255033033769,0.9160027452568094,0.038103224751257554,0.9598912139263411,0.017777983490207674,7451]
["High","O00499","Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",35,15,33,1,593,64.7,5.06,96.43,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","BIN1","ENSG00000136717","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway","Clathrin-mediated endocytosis","Endocytosis; Fc gamma R-mediated phagocytosis",1501,1594.2,1663.1,1855.3,1753.5,1732.3,{"$f":"AVERAGE(T130:V130)/AVERAGE(W130:Y130)","v":0.8908839003201585},{"$f":"LOG(Z130,2)","v":-0.166690662406069},{"$f":"TTEST(T130:V130,W130:Y130,2,2)","v":0.03238155863676829},{"$f":"-LOG10(AB130)","v":1.4897022509792928},{"$f":"AB130*7808/AF130","v":0.1524021759107214},{"$f":"-LOG10(AD130)","v":0.8170088323450181},1659]
["High","O00499-2","Isoform IIB of Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",39,15,35,1,518,56.5,5.12,96.18,"","","","BIN1","","","","",252.5,248.8,246.3,283.5,265.6,281.5,0.9000722369371539,-0.15188730267963696,0.00961915171050283,2.0168632256432346,0.08128391402121872,1.0899953922047059,924]
["High","O00505","Importin subunit alpha-4 [OS=Homo sapiens]",34,14,51,10,521,57.8,4.94,112.11,"cell organization and biogenesis;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","KPNA3","ENSG00000102753","","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis",1142.5,1043.8,1090.9,1120.9,1134.3,1132.4,0.9674105561459441,-0.04779981468440656,0.2705569247040962,0.5677413461435529,0.506111276494869,0.2957539862143528,4174]
["High","O00506","serine/threonine-protein kinase 25 [OS=Homo sapiens]",19,6,24,2,426,48.1,6.74,36.62,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","kinase activity;other molecular function","STK25","ENSG00000115694","","","",70,59.2,62,58.1,53.1,60.4,1.1142191142191142,0.156032970481203,0.16815605503978667,0.7742874897943571,0.3846945437300482,0.41488397341436056,3413]
["High","O00507-1","Probable ubiquitin carboxyl-terminal hydrolase FAF-Y [OS=Homo sapiens]",14,31,68,5,2555,290.9,5.86,132.56,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","USP9Y","ENSG00000114374","","","",68.3,61.1,68.5,78.7,83.5,81.3,0.8127310061601642,-0.29915015992219246,5.5965615695515655E-3,2.25207871406566,0.06278441484922216,1.2021481490175867,696]
["High","O00515","Ladinin-1 [OS=Homo sapiens]",14,6,8,6,517,57.1,9.67,18.53,"","extracellular matrix;cytoskeleton","other molecular function","LAD1","ENSG00000159166","","","",394.5,373.7,404.8,511.1,401.9,409.8,0.8867553674024796,-0.17339193727524393,0.24125765237932428,0.6175189025089091,0.47294495349680243,0.32518940425960163,3983]
["High","O00522","Krev interaction trapped protein 1 [OS=Homo sapiens]",1,1,1,1,736,84.3,8.41,3.49,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","KRIT1","ENSG00000001631","","","Rap1 signaling pathway",84.2,92.1,87,94.1,96.4,104.6,0.8922399186716367,-0.16449639938594443,0.05453290864659524,1.2633413375327398,0.20490517358643678,0.6884470760952629,2078]
["High","O00534","von Willebrand factor A domain-containing protein 5A [OS=Homo sapiens]",10,6,8,6,786,86.4,6.58,19.04,"","nucleus","","VWA5A","ENSG00000110002","","","",299.3,306.3,325.5,247.7,275.1,271.1,1.1728177352311375,0.22997882503776604,0.016881247298191265,1.7725954679764024,0.10812861271884938,0.966059368936149,1219]
["High","O00541-1","Pescadillo homolog [OS=Homo sapiens]",35,19,77,19,588,68,7.33,173.63,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PES1","ENSG00000100029","","Major pathway of rRNA processing in the nucleolus and cytosol","",4273,4448.9,4418.9,4460.2,4686.2,4639.3,0.9532196406421145,-0.06911941700053692,0.07038210677674787,1.1525377373896861,0.2338482934948287,0.6310657950027869,2350]
["Medium","O00559","Receptor-binding cancer antigen expressed on SiSo cells [OS=Homo sapiens]",8,1,1,1,213,24.4,6.29,2.55,"other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","EBAG9","ENSG00000147654","","Estrogen-dependent gene expression","Estrogen signaling pathway",19.2,17.7,18.5,23.7,20.2,21.4,0.8483920367534455,-0.2371970154972426,0.041519981723416456,1.3817428463306276,0.17467026793988993,0.7577810135548355,1856]
["High","O00560-1","Syntenin-1 [OS=Homo sapiens]",40,7,14,7,298,32.4,7.53,38.76,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SDCBP","ENSG00000137575; ENSPPAG00000038846; ENSPTRG00000020277","Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling pathway","Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death","",461.4,485.5,542.2,389.1,386.7,419,1.246317375292936,0.31767149810279244,0.0198133086422055,1.7030429951798245,0.11782354446179781,0.9287679166106685,1313]
["High","O00562","Membrane-associated phosphatidylinositol transfer protein 1 [OS=Homo sapiens]",8,7,7,6,1244,134.8,5.95,14.49,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","PITPNM1","ENSG00000110697","","Synthesis of PI","",398.9,402.8,392.9,390.7,389.6,367.5,1.0407736539466808,0.057656347374390474,0.12594369390774315,0.8998235730617217,0.32615866070701777,0.4865710848792564,3015]
["High","O00566","U3 small nucleolar ribonucleoprotein protein Mpp10 [OS=Homo sapiens]",24,16,43,16,681,78.8,4.86,96.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","MPHOSPH10","ENSG00000124383","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1094.2,1281.5,1246.9,1363.4,1325.9,1368.7,0.8927057663873829,-0.1637433499120008,0.06999985579950375,1.1549028546363762,0.23327310033398435,0.6321353385747035,2343]
["High","O00567","Nucleolar protein 56 [OS=Homo sapiens]",61,28,124,28,594,66,9.19,275.69,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP56","ENSG00000101361","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","Ribosome biogenesis in eukaryotes; Spinocerebellar ataxia",5328.1,5029,5105.3,4958,5241.8,5392.4,0.9916753248419083,-0.012060236281796732,0.7949826769731625,0.09964233471074074,0.8940263202947505,0.04864969530865866,6943]
["High","O00571","ATP-dependent RNA helicase DDX3X [OS=Homo sapiens]",66,41,252,13,662,73.2,7.18,546.44,"cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","DDX3X","ENSG00000215301","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Hepatitis B infection","Neutrophil degranulation","RIG-I-like receptor signaling pathway; Hepatitis B; Viral carcinogenesis",13637,14014.6,13924.4,14661.8,14809,15023.9,0.9344034233290707,-0.09788253512702365,0.003286706601351929,2.483239062909867,0.05012227567061692,1.299969219227062,512]
["High","O00592","Podocalyxin [OS=Homo sapiens]",22,10,69,10,558,58.6,5.49,125.4,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","","PODXL","ENSG00000128567","Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Malignant pleural mesothelioma","","Salmonella infection",3292,3376.3,3358.9,3975.4,3680.7,3931,0.8653761510645459,-0.20860073286919686,0.005476883278482715,2.261466514512338,0.06242847392466138,1.2046172813461282,685]
["High","O00622","Protein CYR61 [OS=Homo sapiens]",23,8,17,8,381,42,8.21,29.16,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi","signal transduction activity or receptor binding;other molecular function","CCN1","ENSG00000142871","Oncostatin M signaling pathway; VEGFA-VEGFR2 signaling pathway; Hypertrophy model","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",581.3,563.9,549.4,403,410.3,441.8,1.3501713010915466,0.4331424587999149,6.2507154833830439E-4,3.204070268623812,0.023577578016548213,1.6275008094220942,207]
["High","O00625","Pirin [OS=Homo sapiens]",27,8,29,8,290,32.1,6.92,33.91,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PIR","ENSG00000087842","","Digestion","",1773.6,1782,1739.8,1883.2,1843.9,1873.2,0.9455564880452832,-0.08076444677211057,0.004351035498048352,2.361407373488798,0.05681084476381528,1.2455687528185733,598]
["High","O00629","Importin subunit alpha-3 [OS=Homo sapiens]",43,16,92,12,521,57.9,4.96,245.96,"transport","other membranes;cytosol;nucleus","other molecular function","KPNA4","ENSG00000186432","Leptin signaling pathway","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis",3722.4,3607,3730.2,3567.3,3593.8,3562.5,1.0313327613861016,0.04450989598919553,0.052358599320829854,1.2810119800619053,0.19932517966701097,0.7004378357716363,2051]
["Low","O00635","E3 ubiquitin-protein ligase TRIM38 [OS=Homo sapiens]",2,1,2,1,465,53.4,7.02,0,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM38","ENSG00000112343","","Interferon gamma signaling","",88.4,79.5,71.1,84.8,86,81.6,0.9469096671949286,-0.07870129211443817,0.43589212478831024,0.36062097725870124,0.656275686530491,0.18291368503339858,5186]
["High","O00743","Serine/threonine-protein phosphatase 6 catalytic subunit [OS=Homo sapiens]",31,8,22,8,305,35.1,5.69,47.21,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","cytosol;mitochondrion;nucleus","other molecular function","PPP6C","ENSG00000119414","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",966.2,917,906.2,910,1014.3,973.4,0.9626255305932292,-0.054953408160724054,0.36692948650085216,0.43541738688112464,0.601129968652676,0.22103162023292652,4766]
["High","O00746","Nucleoside diphosphate kinase, mitochondrial [OS=Homo sapiens]",34,6,16,6,187,20.6,10.29,30.44,"other metabolic processes;transport","other membranes;mitochondrion","kinase activity;other molecular function","NME4","ENSG00000103202","Pyrimidine metabolism","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",1062.3,976.1,983.9,909.8,1007.6,992.8,1.0385196893684283,0.05452856859942599,0.41402177488594316,0.3829768171783193,0.6398816346614101,0.19390035440297704,5052]
["High","O00750","Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [OS=Homo sapiens]",2,3,4,3,1634,184.7,7.3,10.18,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2B","ENSG00000133056","Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)","Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection",111.3,104,124.5,102.4,120.3,115.9,1.0035440047253397,0.005103879288578867,0.9628054736712005,0.01646144937079156,0.9824340222719202,7.6966060674144065E-3,7652]
["High","O00754","Lysosomal alpha-mannosidase [OS=Homo sapiens]",9,8,12,8,1011,113.7,7.28,23.14,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MAN2B1","ENSG00000104774","","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","Other glycan degradation; Lysosome",701.3,677.4,667.3,626.3,597.1,558.6,1.148148148148148,0.1993088082234064,0.016239231877568254,1.7894345169189145,0.10575139491247117,0.9757138953591278,1199]
["High","O00762","Ubiquitin-conjugating enzyme E2 C [OS=Homo sapiens]",23,4,9,4,179,19.6,7.37,12.57,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","UBE2C","ENSG00000175063","Gastric cancer network 1; Gastric cancer network 2","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Ubiquitin mediated proteolysis",616.8,477.7,409,512.3,437.1,381.8,1.1294320913461537,0.17559752932027295,0.46901721136856167,0.3288112198323784,0.6833525632330154,0.16535517221735482,5359]
["High","O00763","Acetyl-CoA carboxylase 2 [OS=Homo sapiens]",3,6,16,1,2458,276.4,6.49,36.48,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","ACACB","ENSG00000076555","AMP-activated protein kinase (AMPK) signaling; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; IL-18 signaling pathway; 7q11.23 copy number variation syndrome","ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP)","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; AMPK signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Glucagon signaling pathway; Insulin resistance; Alcoholic liver disease",53.8,59.9,54.6,47.5,52.8,48.9,1.1280160857908847,0.17378764107471129,0.06253804451261621,1.2038557027326393,0.21877108044556784,0.660010088339545,2232]
["High","O00764-1","Pyridoxal kinase [OS=Homo sapiens]",40,11,42,11,312,35.1,6.13,76.73,"other metabolic processes","non-structural extracellular;nucleus;other cell component","kinase activity;other molecular function","HEL-S-1a; PDXK","ENSG00000160209","","Neutrophil degranulation; Vitamins B6 activation to pyridoxal phosphate","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors",998.2,985.8,999.1,992.4,961.7,949.1,1.0275213557453846,0.03916837882937844,0.12089580861436411,0.9175887556090967,0.3171890032462886,0.4986818778243024,2976]
["High","O00767","acyl-CoA desaturase [OS=Homo sapiens]",11,3,19,3,359,41.5,9,30.34,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","SCD","ENSG00000099194","Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Adipogenesis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; AMPK signaling pathway; Alcoholic liver disease",926.8,841.7,870.5,987.5,814.8,1002.5,0.9408870507701083,-0.08790655054590753,0.4443863477601457,0.3522392917282647,0.6633088517130984,0.17828420709706527,5231]
["High","O14494","Phospholipid phosphatase 1 [OS=Homo sapiens]",11,2,2,2,284,32.1,7.97,6.23,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","PLPP1","ENSG00000067113","Androgen receptor signaling pathway; Androgen receptor signaling pathway; Sphingolipid pathway; Triacylglyceride synthesis; Androgen receptor signaling pathway","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",121.1,106.9,121.1,115.4,125.2,117.1,0.9759575062901873,-0.035109761442471965,0.636649429295425,0.1960996458958439,0.7995751558530929,0.09714070860536428,6217]
["High","O14495","Phospholipid phosphatase 3 [OS=Homo sapiens]",10,3,5,3,311,35.1,9.14,8.06,"cell adhesion;cell-cell signaling;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","PLPP3","ENSG00000162407","Triacylglyceride synthesis; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",243.2,210,223.7,257.7,268.4,268.4,0.8519823788546256,-0.2311045027014361,0.018838120231147757,1.7249624356179547,0.11473326268705279,0.940310656142118,1282]
["High","O14497","AT-rich interactive domain-containing protein 1A [OS=Homo sapiens]",28,46,118,45,2285,241.9,6.7,267.26,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ARID1A","ENSG00000117713","Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",4795.6,5157.7,5317.8,5431.1,5127.7,5232.3,0.9670700584506461,-0.048307686759016095,0.385922048876886,0.4135004081816112,0.6160865585014774,0.21035826634425817,4891]
["High","O14524-1","Nuclear envelope integral membrane protein 1 [OS=Homo sapiens]",9,5,9,5,444,50.6,6.93,16.27,"cell organization and biogenesis","other membranes;nucleus","","NEMP1","ENSG00000166881","","","",450.5,372.8,363.9,427.9,421.3,427.6,0.9298245614035086,-0.10496955960154283,0.3398817105173895,0.4686722047463989,0.5762858622627096,0.23936203462063121,4605]
["High","O14530","Thioredoxin domain-containing protein 9 [OS=Homo sapiens]",36,7,21,7,226,26.5,5.88,38,"","cytosol;cytoskeleton;nucleus;other cell component","","TXNDC9","ENSG00000115514","","","",821.1,746.7,675.1,715.7,637.5,653.4,1.117761387421509,0.1606122437046251,0.17922789934126646,0.7465943853722321,0.39926146592199957,0.3987426030162742,3505]
["High","O14531","dihydropyrimidinase-related protein 4 [OS=Homo sapiens]",21,10,33,10,572,61.8,7.09,65.86,"cell organization and biogenesis;developmental processes;other biological processes","cytosol","cytoskeletal activity;other molecular function","DPYSL4","ENSG00000151640","","CRMPs in Sema3A signaling","",841,929.6,917.4,915.3,907.5,949.5,0.9695920354939941,-0.04455024673709074,0.41011633384339,0.3870929335733075,0.6363649313690758,0.1962937613518846,5032]
["High","O14545","TRAF-type zinc finger domain-containing protein 1 [OS=Homo sapiens]",6,3,6,3,582,64.8,5.29,11.48,"other biological processes","","other molecular function","TRAFD1","ENSG00000135148","","","",365.4,320.9,322.9,331.1,285.1,294.4,1.1082802547770698,0.148322746957101,0.17893966854760032,0.7472933714415921,0.3987331426996756,0.39931766427899995,3504]
["High","O14548","Cytochrome c oxidase subunit 7A-related protein, mitochondrial [OS=Homo sapiens]",11,1,1,1,114,12.6,9.42,3.4,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity","COX7A2L","ENSG00000115944","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",119.7,106.2,99.7,107.9,95.5,109.9,1.039259495691031,0.05555592989519338,0.6097444359817779,0.21485215400469704,0.7818828307022043,0.10685832340058414,6089]
["High","O14561","Acyl carrier protein, mitochondrial [OS=Homo sapiens]",13,2,5,2,156,17.4,4.93,6.75,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","NDUFAB1","ENSG00000004779","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",384.2,253.2,232.6,298.8,264.3,225.9,1.102661596958175,0.14099010072263224,0.6305808259963999,0.20025923893311864,0.7970819312578744,0.09849703561217706,6177]
["High","O14562","Ubiquitin domain-containing protein UBFD1 [OS=Homo sapiens]",33,7,35,7,309,33.4,5.77,62.32,"","","","UBFD1","ENSG00000103353","","","",1546.4,1400.5,1264,1501.6,1249,1250.2,1.0525144971005798,0.07384010478912931,0.5819063552583867,0.23514689965729124,0.7623363795062892,0.11785335473889227,5960]
["High","O14578-4","Isoform 4 of Citron Rho-interacting kinase [OS=Homo sapiens]",19,36,55,36,2069,236.5,6.67,103.88,"","","","CIT","","","","",2391.5,2452.9,2428.2,2334.2,2420.4,2341.1,1.0249305917668445,0.03552621382412754,0.14763474488400438,0.8308114220817535,0.36056680890031473,0.44301425369480607,3197]
["High","O14579-1","coatomer subunit epsilon [OS=Homo sapiens]",34,12,29,12,308,34.5,5.12,61.56,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","COPE","ENSG00000105669; ENSPTRG00000010723","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",1125.6,1068.8,1040.6,1006.3,1058.7,1036.1,1.0431782270807133,0.06098566347525719,0.20161945373166779,0.695467566270616,0.4270875460490673,0.36948309249503564,3686]
["High","O14617-5","Isoform 5 of AP-3 complex subunit delta-1 [OS=Homo sapiens]",39,34,102,4,1215,136.6,7.64,215.34,"","","","AP3D1","","","","",3485.4,3602.9,3607.9,3435.4,3664.9,3599.9,0.9996261752116783,-5.3941599809164428E-4,0.9873680758092325,5.5209187652874555E-3,0.9942442527622501,2.5069107778432362E-3,7754]
["High","O14618","copper chaperone for superoxide dismutase [OS=Homo sapiens]",37,9,26,9,274,29,5.58,58.72,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CCS","ENSG00000173992","Amyotrophic lateral sclerosis (ALS); Copper homeostasis","Detoxification of Reactive Oxygen Species","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",1371.3,1425.6,1300.2,1418.4,1392,1396.4,0.9739231720072262,-0.03812012518328334,0.38144538582335014,0.4185676342056992,0.6133289893963587,0.21230650761426498,4856]
["High","O14628-1","Zinc finger protein 195 [OS=Homo sapiens]",17,8,12,3,629,72.3,8.09,18.84,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF195","ENSG00000005801","","Generic Transcription Pathway","Herpes simplex virus 1 infection",206.9,220.8,220.4,200.6,216.7,219,1.0185447116140185,0.026509312466769377,0.6219986952127292,0.20621052634214931,0.7909716306548843,0.10183909282468162,6140]
["High","O14639-1","Actin-binding LIM protein 1 [OS=Homo sapiens]",8,5,5,5,778,87.6,8.59,7.43,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ABLIM1","ENSG00000099204","Male infertility","DCC mediated attractive signaling","Axon guidance",188.4,168.8,159.1,213.4,149.2,144,1.0191472562179236,0.027362521048858942,0.8990180193685509,0.04623160344596857,0.9521883742850848,0.02127712533436935,7372]
["High","O14641","Segment polarity protein dishevelled homolog DVL-2 [OS=Homo sapiens]",18,12,21,10,736,78.9,6.02,43.31,"cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","DVL2","ENSG00000004975","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)","RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; Degradation of DVL; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",1184.3,1181.3,1225.1,1051.7,1136.3,1099.4,1.092261361562329,0.12731811258861106,0.023247601920281667,1.6336218396128641,0.12901014626407908,0.8893761323889743,1407]
["High","O14646","Chromodomain-helicase-DNA-binding protein 1 [OS=Homo sapiens]",21,35,65,30,1710,196.6,7.14,121.56,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD1","ENSG00000153922","","Estrogen-dependent gene expression","",2864.7,2693.3,2744.7,2951.3,2811.6,3032.3,0.9440035473894852,-0.08313581391083631,0.11603712316168688,0.935403046936698,0.30879954248345304,0.5103233517853265,2934]
["High","O14647","Chromodomain-helicase-DNA-binding protein 2 [OS=Homo sapiens]",13,23,44,18,1828,211.2,8.1,79.25,"cell organization and biogenesis;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CHD2","ENSG00000173575","Prion disease pathway; Male infertility","","",1515.4,1580,1556.3,1670.5,1573.7,1733.9,0.93443281573291,-0.09783715471928538,0.09635579951320594,1.0161221406786556,0.27906011965842437,0.5543022238833023,2696]
["High","O14653-1","Golgi SNAP receptor complex member 2 [OS=Homo sapiens]",24,4,4,4,212,24.8,8.06,11.17,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","GOSR2","ENSG00000108433","","COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER","SNARE interactions in vesicular transport",253.2,231.7,252.6,224.8,270.8,251.3,0.9874146472084615,-0.01827204885810094,0.8456356532563929,0.07281671481357452,0.9242333679487564,0.034218356035429116,7144]
["High","O14656","Torsin-1A [OS=Homo sapiens]",19,5,10,5,332,37.8,6.99,14.35,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TOR1A","ENSG00000136827","","Cargo recognition for clathrin-mediated endocytosis","",296.7,319.6,309.1,299.3,303.9,308.5,1.015026872874849,0.021517923321845076,0.5567706421886225,0.2543236725922143,0.7451602972589586,0.12775029271929275,5834]
["Low","O14657","Torsin-1B [OS=Homo sapiens]",2,1,2,1,336,38,8.54,4.48,"cell organization and biogenesis;stress response;other biological processes","other membranes;ER/Golgi;nucleus","cytoskeletal activity;other molecular function","TOR1B","ENSG00000136816","","Cargo recognition for clathrin-mediated endocytosis","",149,170.1,158.3,146.2,131.4,150.4,1.1154205607476637,0.1575877697932675,0.12135339590078052,0.915948066053641,0.31817572706289265,0.4973329548111629,2978]
["High","O14662-2","Isoform A of Syntaxin-16 [OS=Homo sapiens]",27,6,11,6,304,34.8,6.2,24.64,"","","","STX16","","","","",628.5,588.6,580.4,508,468.4,478.1,1.2358198693709177,0.3054684742263536,3.8749900329692333E-3,2.4117294102240012,0.05402843245968531,1.2673776325715662,560]
["Medium","O14668-1","Transmembrane gamma-carboxyglutamic acid protein 1 [OS=Homo sapiens]",3,1,2,1,218,24.9,5.19,4.45,"","non-structural extracellular;plasma membrane;other membranes","other molecular function","PRRG1","ENSG00000130962; ENSNLEG00000000909","","","",126.7,119.1,120.1,84.7,84.7,83.4,1.447389240506329,0.5334529521619841,9.9660320993096718E-5,4.00147771835595,0.01235155216371586,1.9082784631508962,63]
["High","O14672","Disintegrin and metalloproteinase domain-containing protein 10 [OS=Homo sapiens]",28,17,39,17,748,84.1,7.77,86.88,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM10","ENSG00000137845","Alzheimer's disease and miRNA effects; Copper homeostasis; Canonical and non-canonical Notch signaling; VEGFA-VEGFR2 signaling pathway; 3q29 copy number variation syndrome; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Hypertrophy model","Amyloid fiber formation; Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus","Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection",1320.7,1292.2,1265.9,1402.5,1461.3,1422.4,0.904950772245812,-0.14408878066776895,4.3994790975780095E-3,2.35659874134099,0.056778731890725784,1.2458143113348232,605]
["High","O14681","Etoposide-induced protein 2.4 homolog [OS=Homo sapiens]",8,3,3,3,340,38.9,9.72,7.6,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EI24","ENSG00000149547","miRNA regulation of p53 pathway in prostate cancer","","p53 signaling pathway",268.8,266.7,265.5,250.2,254.4,259.3,1.04856656630449,0.06841845116174977,0.011551924346767132,1.9373456639476665,0.08782612005799198,1.0563763028863093,1027]
["High","O14682","Ectoderm-neural cortex protein 1 [OS=Homo sapiens]",3,2,4,2,589,66.1,6.84,7.6,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity","ENC1","ENSG00000171617","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","",199.8,198.6,200.5,226.9,189.6,188,0.9907361455748552,-0.013427207158099043,0.8904324058254692,0.05039904295110459,0.9492758362486706,0.022607573922128057,7324]
["High","O14683","Tumor protein p53-inducible protein 11 [OS=Homo sapiens]",18,3,12,3,189,21,9.55,34.84,"other biological processes","other membranes","","TP53I11","ENSG00000175274","","","",416.5,364,348,363.4,387.5,368.9,1.007769244507948,0.011165333366206108,0.9012080614825176,0.04517493208167937,0.9529567367355766,0.020926815440899634,7384]
["High","O14686-1","Histone-lysine N-methyltransferase 2D [OS=Homo sapiens]",5,20,31,20,5537,593,5.58,54.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KMT2D","ENSG00000167548","Histone modifications; 16p11.2 proximal deletion syndrome","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Lysine degradation; Metabolic pathways; Cushing syndrome",916.9,996.1,1038.4,1043.9,1007.9,1040.7,0.9543734842360551,-0.06737413430660992,0.2771913618814767,0.55722030777474,0.5127482003247027,0.2900958552705127,4221]
["High","O14717-1","tRNA (cytosine(38)-C(5))-methyltransferase [OS=Homo sapiens]",7,2,2,2,391,44.6,6.09,4.6,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT2; TRDMT1","ENSG00000107614","","tRNA modification in the nucleus and cytosol","",16,9.9,16.2,14.5,12.1,16.5,0.976798143851508,-0.03386763602270226,0.8974113395267848,0.04700844710203513,0.9522951534418503,0.021228425938507968,7358]
["High","O14727","apoptotic protease-activating factor 1 [OS=Homo sapiens]",4,5,6,5,1248,141.7,6.4,12.17,"stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;other cell component","enzyme regulator activity;other molecular function","APAF1","ENSG00000120868","miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkinson's disease pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; p53 transcriptional gene network; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response","Neutrophil degranulation; Transcriptional Regulation by E2F6; Formation of apoptosome; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of the apoptosome activity","Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Legionellosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Small cell lung cancer; Lipid and atherosclerosis",314.3,285.5,278.2,274.7,288.6,287.1,1.0324553151458138,0.04607934289161593,0.48149123856561804,0.3174116110881997,0.693247942231301,0.15911141086501937,5423]
["High","O14730","serine/threonine-protein kinase RIO3 [OS=Homo sapiens]",8,4,5,4,519,59.1,5.76,6.55,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;other cell component","kinase activity;other molecular function","RIOK3","ENSG00000101782","","Major pathway of rRNA processing in the nucleolus and cytosol","",146,147.4,153.7,156.3,170.7,169.8,0.8999597423510467,-0.15206762767783966,0.03383123546901831,1.4706821421002862,0.15529352530399468,0.8088466510542198,1701]
["High","O14732-1","inositol monophosphatase 2 [OS=Homo sapiens]",17,4,6,4,288,31.3,6.61,13.79,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA2","ENSG00000141401","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",469.9,414.4,406.8,423.4,430.8,440.3,0.9973735032831208,-3.7942187239295025E-3,0.9585239034795958,0.018397052300948173,0.980885273704939,0.008381785597193192,7630]
["High","O14733","dual specificity mitogen-activated protein kinase kinase 7 [OS=Homo sapiens]",15,5,15,5,419,47.5,9.16,22,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAP2K7","ENSG00000076984","MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; MAPK signaling pathway; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; Alzheimer's disease; ErbB signaling pathway; Toll-like receptor signaling pathway","FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Uptake and function of anthrax toxins","MAPK signaling pathway; ErbB signaling pathway; Protein processing in endoplasmic reticulum; Osteoclast differentiation; Tight junction; Toll-like receptor signaling pathway; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Relaxin signaling pathway; Alcoholic liver disease; Alzheimer disease; Huntington disease; Pathways of neurodegeneration; Salmonella infection; Yersinia infection; Hepatitis B; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Chemical carcinogenesis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",725.7,717,700.4,719.2,743.3,785.6,0.9532938926204351,-0.06900704123284948,0.16736017186282717,0.7763478868338572,0.3841117642283817,0.4155423914517721,3402]
["High","O14734","Acyl-coenzyme A thioesterase 8 [OS=Homo sapiens]",22,4,5,4,319,35.9,7.56,17.22,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOT8","ENSG00000101473","","Peroxisomal protein import; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids","Primary bile acid biosynthesis; Metabolic pathways; Peroxisome",73,74.6,67.9,69.5,96.1,78.4,0.8831967213114754,-0.17919327847378813,0.30460707826860506,0.5162600090194119,0.5407849174900564,0.2669754293855482,4398]
["High","O14735","CDP-diacylglycerol--inositol 3-phosphatidyltransferase [OS=Homo sapiens]",19,4,6,4,213,23.5,8.03,11.57,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","CDIPT","ENSG00000103502","Glycerolipids and glycerophospholipids; 16p11.2 proximal deletion syndrome","Synthesis of PI","Inositol phosphate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system",484.8,507.1,548.8,483.9,454.7,449.6,1.109854487825962,0.1503705383293155,0.07809598858118048,1.1073712731879979,0.24960027787222974,0.6027549355027992,2443]
["High","O14744","Protein arginine N-methyltransferase 5 [OS=Homo sapiens]",39,22,81,22,637,72.6,6.29,162.25,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","PRMT5","ENSG00000100462","Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis","RMTs methylate histone arginines; snRNP Assembly; Regulation of TP53 Activity through Methylation","",3522.3,3414.4,3499.9,3411.4,3594.4,3567.6,{"$f":"AVERAGE(T194:V194)/AVERAGE(W194:Y194)","v":0.9870618722454462},{"$f":"LOG(Z194,2)","v":-0.018787574558298506},{"$f":"TTEST(T194:V194,W194:Y194,2,2)","v":0.52675605046606},{"$f":"-LOG10(AB194)","v":0.27839046726436795},{"$f":"AB194*7808/AF194","v":0.7247420690817615},{"$f":"-LOG10(AD194)","v":0.13981652847089288},5675]
["High","O14745","Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [OS=Homo sapiens]",44,13,23,13,358,38.8,5.77,51.87,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function","SLC9A3R1","ENSG00000109062","","","Tight junction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human papillomavirus infection",1022.8,977.9,830.8,1068.7,764.2,723.6,1.1075689419127714,0.14739650380063848,0.4987499258646825,0.30211715585970506,0.7058617765364221,0.15128033515880954,5517]
["High","O14757","Serine/threonine-protein kinase Chk1 [OS=Homo sapiens]",22,9,14,9,476,54.4,8.25,28.33,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CHEK1","ENSG00000149554","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; DNA damage response","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis",599.5,620.3,606.2,791,950.8,885.6,0.6949836340108091,-0.524949090302223,0.004655491178259557,2.332034491964187,0.0577902625116862,1.2381453327508203,629]
["High","O14763","Tumor necrosis factor receptor superfamily member 10B [OS=Homo sapiens]",11,3,7,3,440,47.8,5.55,2.63,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TNFRSF10B","ENSG00000120889","miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer; miRNA regulation of p53 pathway in prostate cancer; Unfolded protein response; DNA damage response","Cell surface interactions at the vascular wall; Regulation by c-FLIP; RIPK1-mediated regulated necrosis; CASP8 activity is inhibited; TP53 Regulates Transcription of Death Receptors and Ligands; Dimerization of procaspase-8; TRAIL  signaling","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; p53 signaling pathway; Apoptosis; Necroptosis; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Salmonella infection; Influenza A; Lipid and atherosclerosis",43.9,39.6,44,45.2,53.9,50.2,0.8539852645679838,-0.22771691838832114,0.06686225857968171,1.1748189572061258,0.22668715370827391,0.6445730905117215,2303]
["High","O14772","fucose-1-phosphate guanylyltransferase [OS=Homo sapiens]",7,4,5,3,594,66.6,6.48,10.02,"","","other molecular function","FPGT","ENSG00000254685","","","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",121.3,114.5,127.2,127.6,134.8,121.8,0.9448204060385216,-0.08188797078241412,0.24979562526306892,0.6024151718095445,0.4837312108268954,0.315395890588378,4032]
["High","O14773","Tripeptidyl-peptidase 1 [OS=Homo sapiens]",20,7,15,7,563,61.2,6.48,42.56,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TPP1","ENSG00000166340","VEGFA-VEGFR2 signaling pathway","XBP1(S) activates chaperone genes","Lysosome",1010.8,1087.1,1090.4,1006.9,1079.6,1056.7,1.0143484347162128,0.020553311798469698,0.6787293413897854,0.16830337590321984,0.8253416442254234,0.08336624116107906,6421]
["High","O14775","Guanine nucleotide-binding protein subunit beta-5 [OS=Homo sapiens]",8,2,2,2,395,43.5,6.46,6.36,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","GNB5","ENSG00000069966","Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells","G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits","Ras signaling pathway; Chemokine signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Relaxin signaling pathway; Morphine addiction; Alcoholism; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",35.1,28.4,40.6,34.8,42,35.7,0.9253333333333332,-0.11195493280498248,0.540741986724216,0.2670099076674023,0.733515189774614,0.1345908882733345,5756]
["High","O14776-1","Transcription elongation regulator 1 [OS=Homo sapiens]",26,34,100,34,1098,123.8,8.65,216.66,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","TCERG1","ENSG00000113649; ENSGGOG00000003329; ENSPTRG00000017375","","","Spliceosome",6682.7,7352.7,7382.2,8191.5,7588,7916,0.9038678230043679,-0.14581627914765435,0.0574617684951692,1.2406210119000394,0.21083716560633511,0.6760528308644146,2128]
["High","O14777","Kinetochore protein NDC80 homolog [OS=Homo sapiens]",36,20,40,20,642,73.9,5.6,78.95,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NDC80","ENSG00000080986","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",2416.3,2450,2428.6,2582.1,2464.5,2445.5,0.9736789418187156,-0.038481954410254544,0.2081508184729569,0.6816218770779969,0.43595536229529175,0.3605579761013052,3728]
["High","O14782","Kinesin-like protein KIF3C [OS=Homo sapiens]",6,5,5,2,793,89.4,8.22,13.05,"transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3C","ENSG00000084731","","Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",59.7,57.7,56.2,64.6,71,64.1,0.869303955933901,-0.20206738499949303,0.023522824687896314,1.628510528144032,0.12979944534494306,0.8867271633457054,1415]
["High","O14787-2","Isoform 2 of Transportin-2 [OS=Homo sapiens]",34,24,72,12,887,100.3,4.98,136.86,"","","","TNPO2","","","","",1247.6,1197.5,1260.4,1127,1119.9,1157.6,1.0884123953590836,0.12222529189248495,0.011010806864491858,1.9581808550557696,0.08554465671438052,1.0678071121536419,1005]
["High","O14795","Protein unc-13 homolog B [OS=Homo sapiens]",9,12,19,11,1591,180.6,5.99,27.15,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","UNC13B","ENSG00000198722","Synaptic vesicle pathway; 16p11.2 proximal deletion syndrome; Monoamine transport","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle","Synaptic vesicle cycle",607.5,598.8,572.8,613.9,585.2,597,0.9905350481599021,-0.013720071905945944,0.6928946456239242,0.15933279468472988,0.8351530399863539,0.07823393370025256,6478]
["Medium","O14798","Tumor necrosis factor receptor superfamily member 10C [OS=Homo sapiens]",4,1,1,1,259,27.4,4.82,2.91,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TNFRSF10C","ENSG00000173535","Apoptosis modulation and signaling; VEGFA-VEGFR2 signaling pathway","TP53 Regulates Transcription of Death Receptors and Ligands","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor",82.5,79.5,79,85.1,67.6,81.5,1.0290350128095644,0.04129207061610883,0.6986358739138279,0.15574911774960026,0.8384489553518549,0.07652337203679961,6506]
["High","O14802","DNA-directed RNA polymerase III subunit RPC1 [OS=Homo sapiens]",28,29,60,28,1390,155.5,8.48,110.91,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3A","ENSG00000148606","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",2115.4,2207.2,2203.7,2155.8,2243.5,2177,0.9923969405288688,-0.011010807350118538,0.698307473461637,0.1559533100056947,0.8381836668391178,0.0766608062446644,6505]
["High","O14818-1","Proteasome subunit alpha type-7 [OS=Homo sapiens]",66,16,112,16,248,27.9,8.46,245.84,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","HEL-S-276; PSMA7","ENSG00000101182","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",4895,4769,4958.2,4898.8,5158.8,4812.4,0.9833355749831876,-0.02424425741944819,0.5225729563505888,0.2818530691812337,0.722423803680134,0.14120795256634563,5648]
["Low","O14827","Ras-specific guanine nucleotide-releasing factor 2 [OS=Homo sapiens]",1,1,1,1,1237,140.7,7.53,0,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","RASGRF2","ENSG00000113319","MAPK signaling pathway; Ras signaling","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor","MAPK signaling pathway; Ras signaling pathway",80.5,95,96.7,93.3,103.9,93.2,0.9373278236914601,-0.09337438649175603,0.38647081930213933,0.41288329215830455,0.616458459062534,0.21009618363882576,4895]
["High","O14828","Secretory carrier-associated membrane protein 3 [OS=Homo sapiens]",41,9,31,9,347,38.3,7.64,88.4,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCAMP3","ENSG00000116521; ENSG00000263290","","","",717.4,707,703.8,671.9,644.6,688.5,1.0614463840399002,0.08603149942669985,0.037822564888264625,1.4222490233743805,0.16352081209721495,0.7864269646932321,1806]
["High","O14832","Phytanoyl-CoA dioxygenase, peroxisomal [OS=Homo sapiens]",10,4,8,4,338,38.5,8.47,16,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","PHYH","ENSG00000107537","","TYSND1 cleaves peroxisomal proteins; Alpha-oxidation of phytanate","Peroxisome",714.6,717.6,721.6,713.8,677.9,671.2,1.0440641814920746,0.06221040105938841,0.08624387322574081,1.0642717474867232,0.2638684020950565,0.5786126128772126,2552]
["High","O14841","5-oxoprolinase [OS=Homo sapiens]",10,9,11,9,1288,137.4,6.58,25.59,"other metabolic processes","cytosol","other molecular function","OPLAH","ENSG00000178814","Glutathione metabolism","Glutathione synthesis and recycling; Defective OPLAH causes OPLAHD","Glutathione metabolism; Metabolic pathways",160.1,150.2,146.1,134.7,151.1,147.1,1.0542850542850544,0.07626499107632748,0.29155275308124956,0.5352828532573434,0.529405557222883,0.2762115041782945,4300]
["High","O14867","Transcription regulator protein BACH1 [OS=Homo sapiens]",29,17,28,17,736,81.9,5.05,55.25,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH1","ENSG00000156273","Integrated cancer pathway; Ferroptosis","Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity","",1136.4,1188.6,1141.6,1001.9,905.7,922.1,1.225076863271725,0.29287226905001384,3.366157946615237E-3,2.4728655099484023,0.05054415624456109,1.2963290489245658,520]
["Medium","O14874","[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial [OS=Homo sapiens]",4,1,1,1,412,46.3,8.82,2.17,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","BCKDK","ENSG00000103507","Thiamine metabolic pathways","Branched-chain amino acid catabolism","",15.2,13.1,13.5,12.9,15.3,16.6,0.9330357142857141,-0.09999578997672168,0.4719894405330174,0.32606771740307466,0.6848715018921762,0.16439090479093313,5381]
["High","O14880","Microsomal glutathione S-transferase 3 [OS=Homo sapiens]",28,3,20,3,152,16.5,9.38,43.62,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","MGST3","ENSG00000143198","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II","Aflatoxin activation and detoxification; Glutathione conjugation","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",503.6,503.1,500.2,440.3,514.9,481.5,1.0488619753602004,0.06882483943582829,0.33960428212731053,0.4690268423016507,0.5764413554021828,0.23924486932458938,4600]
["High","O14893","Gem-associated protein 2 [OS=Homo sapiens]",29,7,13,7,280,31.6,5.58,27.35,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","GEMIN2","ENSG00000092208","","snRNP Assembly","",439.8,415.9,407.3,444.1,422.3,454.6,0.9560938682816049,-0.06477582745927526,0.22825949254510097,0.6415711525702957,0.4599355142689415,0.3373030547539894,3875]
["Medium","O14896-1","Interferon regulatory factor 6 [OS=Homo sapiens]",3,1,1,1,467,53.1,5.33,0,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IRF6","ENSCANG00000037044; ENSCATG00000039683; ENSG00000117595; ENSGGOG00000006214; ENSMFAG00000033961; ENSMMUG00000022065; ENSMNEG00000040867; ENSNLEG00000001962; ENSPPAG00000032756; ENSPPYG00000000253; ENSPTRG00000001941","Apoptosis; Primary focal segmental glomerulosclerosis (FSGS); Hypothetical craniofacial development pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway","Interferon gamma signaling; Interferon alpha/beta signaling","",10.3,12.2,16.5,14,8.8,13.1,1.0863509749303621,0.11949027992655939,0.6933328523316564,0.15905822104985262,0.8351655215991319,0.0782274430874084,6482]
["High","O14907","Tax1-binding protein 3 [OS=Homo sapiens]",26,3,6,3,124,13.7,8.48,13.43,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TAX1BP3","ENSG00000213977","","RHO GTPases Activate Rhotekin and Rhophilins","",265.9,258.1,235,190.8,192.8,205.6,1.2881873727087576,0.3653424552669794,0.005479702821290897,2.261242993810002,0.06236956214087364,1.2050273048581184,686]
["High","O14908-1","PDZ domain-containing protein GIPC1 [OS=Homo sapiens]",32,8,18,8,333,36,6.28,43.29,"cell-cell signaling;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GIPC1","ENSG00000123159","VEGFA-VEGFR2 signaling pathway","","",1301.6,1274.3,1322.1,1317.1,1243,1299,1.010080070482755,0.014469661996536874,0.6472460187629445,0.18893061224821125,0.8067843094669653,0.09324255663946283,6264]
["High","O14910","Protein lin-7 homolog A [OS=Homo sapiens]",15,4,11,2,233,26,8.72,19.9,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","LIN7A","ENSG00000111052","","Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle","",467.7,463.8,412,500.7,440.3,421.6,0.9859826801702627,-0.020365790527515644,0.841614993591808,0.07488653605133597,0.922421374223026,0.035070642183906514,7124]
["High","O14920-1","Inhibitor of nuclear factor kappa-B kinase subunit beta [OS=Homo sapiens]",15,6,9,6,756,86.5,5.78,13.02,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","IKBKB","ENSG00000104365","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",162.3,163.5,158.2,170.1,187.2,181.4,0.8984592537590498,-0.1544750176771383,0.025835311136735945,1.5877863038433486,0.13529316522846027,0.8687241426377077,1491]
["High","O14924","Regulator of G-protein signaling 12 [OS=Homo sapiens]",4,5,5,4,1447,156.3,7.44,4.95,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","RGS12","ENSG00000159788","","G alpha (i) signalling events","",16.6,17.7,15.9,18.9,19.1,15,0.9471698113207545,-0.07830499549978986,0.5505594602506783,0.25919577049012227,0.7405285556653396,0.13045818990607946,5805]
["High","O14929","histone acetyltransferase type B catalytic subunit [OS=Homo sapiens]",35,10,88,10,419,49.5,5.69,190.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","HAT1","ENSG00000128708","Ethanol effects on histone modifications","HATs acetylate histones","Neutrophil extracellular trap formation; Alcoholism",3004.7,3027.1,3074.9,2873.4,3083.5,2958.7,1.0214343398088743,0.030596467236375158,0.37875188125206566,0.4216452013533689,0.611263887725533,0.21377126072059444,4838]
["Medium","O14933","Ubiquitin/ISG15-conjugating enzyme E2 L6 [OS=Homo sapiens]",5,1,2,1,153,17.8,7.88,4.52,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UBE2L6","ENSG00000156587","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome","Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration",122.7,113.9,106.1,140.9,104.2,100.4,0.9918958031837917,-0.01173951875644634,0.9492311698549358,0.022628009315062352,0.9762377468687222,0.010444404075663197,7592]
["High","O14936","peripheral plasma membrane protein CASK [OS=Homo sapiens]",29,23,54,23,926,105.1,6.43,119,"cell adhesion;protein metabolism;other metabolic processes;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CASK","ENSG00000147044","Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions","",3162.4,3165.5,3347.5,3035,3239,3119,1.0300649419780687,0.04273529713294429,0.330891134514342,0.48031486863065576,0.5685734987429538,0.24521338667498285,4544]
["High","O14939-1","Phospholipase D2 [OS=Homo sapiens]",5,5,6,5,933,105.9,7.64,8.76,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","PLD2","ENSG00000129219","Ras signaling; EGF/EGFR signaling pathway","Role of phospholipids in phagocytosis; RAC1 GTPase cycle; RAC2 GTPase cycle; Synthesis of PG; Synthesis of PA","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways; Ras signaling pathway; cAMP signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Endocytosis; Fc gamma R-mediated phagocytosis; Glutamatergic synapse; GnRH signaling pathway; Parathyroid hormone synthesis, secretion and action; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Choline metabolism in cancer",348.6,357.6,378.2,312.2,324.9,313.7,1.1405132519983172,0.18968320989527704,0.009860884118220396,2.006084144850792,0.08182123612653013,1.0871339636194133,941]
["High","O14949","Cytochrome b-c1 complex subunit 8 [OS=Homo sapiens]",29,3,6,3,82,9.9,10.08,11.63,"other metabolic processes;transport;developmental processes","other membranes;mitochondrion","","UQCRQ","ENSG00000164405","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly","Respiratory electron transport","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",634.1,523.1,455.6,497.1,553.4,533.5,1.0181818181818183,0.025995208532944673,0.8689372800139626,0.0610115698423259,0.9360737144521276,0.02868994985244711,7248]
["High","O14950","Myosin regulatory light chain 12B [OS=Homo sapiens]",40,6,23,6,172,19.8,4.84,56.04,"other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL12B","ENSG00000118680","Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion","RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Salmonella infection",717.7,549.6,476.1,599.7,449.7,473.8,1.144564075630252,0.1947982309201609,0.4380260120842956,0.35850009824194257,0.6580925730910486,0.1817130104061667,5197]
["High","O14964","Hepatocyte growth factor-regulated tyrosine kinase substrate [OS=Homo sapiens]",24,16,34,16,777,86.1,6.16,73.13,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","HGS","ENSG00000185359","TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway","Lysosome Vesicle Biogenesis; Ub-specific processing proteases; Cargo recognition for clathrin-mediated endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle","Endocytosis; Phagosome",1547.2,1615.8,1609,1599.1,1499.7,1559.4,1.024430037353484,0.03482145998632128,0.3538697062760686,0.45115661441889504,0.5900095380319333,0.22914096754233956,4683]
["High","O14965","Aurora kinase A [OS=Homo sapiens]",16,5,11,5,403,45.8,9.39,24.71,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AURKA","ENSG00000087586","Gastric cancer network 1; EGF/EGFR signaling pathway","Regulation of TP53 Activity through Phosphorylation; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA","Oocyte meiosis; Progesterone-mediated oocyte maturation",241.7,228.3,243.8,250.8,257.3,258.9,0.9306388526727509,-0.10370667634127316,0.03126216010326159,1.5049810170872828,0.14993547056895976,0.8240956129818298,1628]
["High","O14966-1","Ras-related protein Rab-7L1 [OS=Homo sapiens]",23,4,5,4,203,23.1,7.18,10.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB29; RAB7L1","ENSG00000117280; ENSNLEG00000029152; ENSPPAG00000013675; ENSPPYG00000000298; ENSPTRG00000001905","","RAB geranylgeranylation","",429.7,428.8,422.7,455.2,493.6,480.5,0.896382844749178,-0.15781305651665456,0.012652841585840397,1.897811929313141,0.09250317144404666,1.033843377347043,1068]
["High","O14967","calmegin [OS=Homo sapiens]",28,13,34,12,610,70,4.69,44.08,"cell organization and biogenesis;stress response;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","CLGN","ENSG00000153132","","","",1183,1212.9,1247,1226.7,1270.6,1217.4,0.9806713866530271,-0.02815831039843882,0.3877299915652646,0.41147060428676563,0.6174578368634686,0.20939269287430842,4903]
["High","O14972","Down syndrome critical region protein 3 [OS=Homo sapiens]",8,2,3,2,297,33,7.68,5.94,"transport","other cytoplasmic organelle","","VPS26C","ENSG00000157538","","","",78.2,77,76.9,76.3,77.2,79.5,0.9961373390557938,-0.005583432197160437,0.7873832488832523,0.10381382880785874,0.8889370166686573,0.05112900875110827,6916]
["High","O14974","Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",49,45,141,44,1030,115.2,5.4,267.69,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12A","ENSG00000058272","Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton","Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","cGMP-PKG signaling pathway; cAMP signaling pathway; Vascular smooth muscle contraction; Focal adhesion; Platelet activation; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer",7187.9,7373.1,7422.1,6996.8,6526,6694.9,1.0873195269491585,0.120775962632958,0.01919096306558731,1.71690323039348,0.1156196293334149,0.9369684272694191,1296]
["Medium","O14975","very long-chain acyl-CoA synthetase [OS=Homo sapiens]",2,1,1,1,620,70.3,8.51,0,"other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC27A2","ENSG00000140284","PPAR signaling pathway","Peroxisomal protein import; Neutrophil degranulation; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Alpha-oxidation of phytanate; Synthesis of bile acids and bile salts via 24-hydroxycholesterol","PPAR signaling pathway; Peroxisome; Insulin resistance",24.2,23,19,19.3,27.1,21,0.9821958456973293,-0.025917374374640856,0.8948863432905497,0.04823211956249347,0.9510375076102644,0.0218023547482346,7347]
["High","O14976","Cyclin-G-associated kinase [OS=Homo sapiens]",20,15,36,15,1311,143.1,5.73,66.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","GAK","ENSG00000178950","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","",974.5,1002.9,976,1031.2,1100.1,1056.3,0.9265277952064247,-0.11009383811137081,0.024338296972490615,1.6137098139993749,0.13151101921190775,0.8810378564333061,1445]
["High","O14979-1","Heterogeneous nuclear ribonucleoprotein D-like [OS=Homo sapiens]",29,14,153,12,420,46.4,9.57,280.03,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPDL; HNRPDL","ENSG00000152795; ENSPPAG00000043177; ENSPTRG00000016217","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",4498.1,4758.1,4616.8,5138.9,5004.2,5184.7,0.9050874880935293,-0.14387084132338088,0.006363541093566331,2.1963011470201064,0.06714395791698097,1.172993062092447,740]
["High","O14980","Exportin-1 [OS=Homo sapiens]",44,39,187,39,1071,123.3,6.06,400.66,"transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPO1","ENSG00000082898","eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MAPK6/MAPK4 signaling; Deactivation of the beta-catenin transactivating complex; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Heme signaling; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Influenza A; Human T-cell leukemia virus 1 infection",8287.1,8210.5,8295.1,8362.6,9213.2,8926.3,0.9354994509869026,-0.09619128809014903,0.08596840986214321,1.0656611062323558,0.26343851813328656,0.5793207252370332,2548]
["High","O14981","TATA-binding protein-associated factor 172 [OS=Homo sapiens]",10,13,29,13,1849,206.8,6.52,67.1,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BTAF1","ENSG00000095564","","","",900.9,928,908,869.1,845.2,868.7,1.059581881533101,0.08349507946774766,0.010577670291892612,1.975609974152286,0.08401876870711852,1.075623687325786,983]
["High","O14994","Synapsin-3 [OS=Homo sapiens]",5,2,2,2,580,63.3,9.39,2.45,"cell-cell signaling;transport;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","SYN3","ENSG00000185666","Synaptic vesicle pathway","Serotonin Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle","",94.2,90.8,86.3,132.8,147.2,123.7,0.6720336883824622,-0.5733945391986438,3.6144224666999087E-3,2.4419610869069257,0.05168756523808221,1.2866139249530277,546]
["High","O15013","rho guanine nucleotide exchange factor 10 [OS=Homo sapiens]",12,11,18,11,1369,151.5,5.68,26.01,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity","ARHGEF10","ENSG00000104728; ENSG00000274726","","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events","",644.2,687.7,677.2,626.4,654.6,680.4,1.024319363719792,0.034665590944889205,0.47865861358673767,0.31997412143788506,0.6905702983897353,0.16079210470483507,5412]
["High","O15014","zinc finger protein 609 [OS=Homo sapiens]",10,15,23,14,1411,151.1,8.03,37.1,"developmental processes;other biological processes","nucleus","other molecular function","ZNF609","ENSG00000180357","","","",1185.3,1191.4,1176.3,1305.5,1080.6,1149.2,1.0050066472435153,7.205043606731739E-3,0.9337586136637706,0.02976537891213759,0.968875382788933,0.013732078519383118,7525]
["High","O15015","Zinc finger protein 646 [OS=Homo sapiens]",6,10,10,9,1829,200.6,7.33,23.91,"","","","","","","","",511.9,498.6,488.7,517.1,493.9,510.6,0.9852786540483702,-0.02139629320137647,0.48181578219636617,0.3171189785001136,0.693203911440801,0.15913899542095444,5427]
["High","O15020","Spectrin beta chain, non-erythrocytic 2 [OS=Homo sapiens]",26,51,98,39,2390,271.2,6.11,197.61,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTBN2","ENSG00000173898","","MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","Spinocerebellar ataxia; Pathways of neurodegeneration",1809.9,1898.7,1880.6,1769.7,1840,1770.8,1.0387882167084845,0.054901554291981965,0.12316439067937539,0.9095148373570533,0.3208767308723934,0.4936617756440627,2997]
["High","O15027-5","Isoform 5 of Protein transport protein Sec16A [OS=Homo sapiens]",16,27,61,27,2201,235.6,5.67,122.53,"","","","","","","","",2348.1,2465.5,2452.5,2402.1,2268.4,2306.2,1.0414809293792193,0.058636422343588714,0.151106493382753,0.8207168726582881,0.3642604199853459,0.4385880160098296,3239]
["High","O15031","Plexin-B2 [OS=Homo sapiens]",15,19,27,19,1838,205,6.24,58.63,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PLXNB2","ENSG00000196576","","","Axon guidance",921.8,897.7,940.2,884.6,871.9,852.3,1.0578426862925483,0.0811250976029164,0.03140622123261841,1.5029843143670458,0.15025721530899788,0.8231646641262528,1632]
["High","O15037","protein KHNYN [OS=Homo sapiens]",8,3,4,3,678,74.5,7.02,11.83,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHNYN","ENSG00000100441","","","",240.4,162.7,184.7,161.1,161.8,161.5,1.2134599504541699,0.2791264939570035,0.21033611310616143,0.6770861558621075,0.43876686378116714,0.357766178317894,3743]
["Medium","O15040","Tectonin beta-propeller repeat-containing protein 2 [OS=Homo sapiens]",1,1,1,1,1411,153.8,5.55,2.2,"other metabolic processes;transport","other cell component","","TECPR2","ENSG00000196663","","","",22.3,31.7,16.2,23.7,18.5,17.7,1.1719532554257095,0.22891502751577503,0.520893516431543,0.28325104820279495,0.7213793147033501,0.14183631507974304,5638]
["High","O15042","U2 snRNP-associated SURP motif-containing protein [OS=Homo sapiens]",34,28,87,28,1029,118.2,8.47,154.17,"RNA metabolism OR transcription;other metabolic processes","nucleus","","U2SURP","ENSG00000163714","","mRNA Splicing - Major Pathway","Spliceosome",3843.8,3986.3,4065.5,4470.7,4276.8,4403.2,0.9045602135247555,-0.1447115534978039,0.008330936803057397,2.0793061599950358,0.0767074935828681,1.115162207593114,848]
["High","O15047","Histone-lysine N-methyltransferase SETD1A [OS=Homo sapiens]",11,13,20,12,1707,185.9,5.14,42.36,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETD1A","ENSG00000099381","Histone modifications","PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Lysine degradation; Metabolic pathways",646.7,628.1,608.9,645.2,598,633.4,1.0037834381327935,0.005448047742434233,0.9011659982533585,0.04519520293302621,0.9530413266100803,0.02088826669685578,7383]
["Low","O15050","TPR and ankyrin repeat-containing protein 1 [OS=Homo sapiens]",0,1,1,1,2925,336,6.76,0,"","","","TRANK1","ENSG00000168016","","","",49.7,57.1,45.1,55.3,47.1,43.3,1.0425531914893618,0.06012099243757093,0.6991860432680015,0.15540724941282427,0.8385936445217443,0.07644843332238081,6510]
["High","O15054","Lysine-specific demethylase 6B [OS=Homo sapiens]",2,2,2,2,1643,176.5,8.54,2.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6B","ENSG00000132510","Pathways affected in adenoid cystic carcinoma; Vitamin D-sensitive calcium signaling in depression","Oxidative Stress Induced Senescence; HDMs demethylate histones","",62.2,63.2,46.3,58.3,61.6,53,0.9930595720069403,-0.010047829640147827,0.9502131456654017,0.022178965654917202,0.9764759464800549,0.010338450214983327,7598]
["High","O15056","Synaptojanin-2 [OS=Homo sapiens]",3,5,5,5,1496,165.4,7.34,10.21,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ2","ENSG00000078269","","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",210,195.2,214.9,213.9,228,238.3,0.9116436342252279,-0.13345811656123824,0.09560378385757694,1.0195249186449702,0.27770622930058064,0.5564143783681225,2688]
["High","O15061-1","Synemin [OS=Homo sapiens]",3,3,3,3,1565,172.7,5.16,2.25,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SYNM","ENSG00000182253","","","",26.5,30.5,25.6,24.1,26.1,20.7,1.1650211565585329,0.22035615417992896,0.1481188363367731,0.8293897085487589,0.3615229365794075,0.44186414397423057,3199]
["High","O15063","Uncharacterized protein KIAA0355 [OS=Homo sapiens]",4,3,3,3,1070,115.9,7.15,9.75,"signal transduction","cytosol;other cell component","other molecular function","GARRE1","ENSG00000166398","","RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",99.6,121.8,112.6,110.1,116.5,106,1.00420926037282,0.006059934074145379,0.9509403018939274,0.021846746334761427,0.97683750522139,0.010177674208549465,7601]
["High","O15066","Kinesin-like protein KIF3B [OS=Homo sapiens]",12,9,10,6,747,85.1,7.69,24.97,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3B","ENSG00000101350","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",532.4,558,573.5,577.9,605.5,615.9,0.9247485133107318,-0.11286701891193189,0.05212806093977355,1.2829284296637902,0.19893250235471743,0.7012942543812961,2046]
["High","O15067","Phosphoribosylformylglycinamidine synthase [OS=Homo sapiens]",35,36,100,36,1338,144.6,5.76,222.91,"other metabolic processes;other biological processes","cytosol","other molecular function","PFAS","ENSG00000178921","","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Metabolic pathways",4581.5,4553.5,4526.3,4922.7,4720.6,4724.6,0.950820927205785,-0.07275443809023854,0.026436460117438703,1.5777966979906797,0.1370623377137858,0.863081865196726,1506]
["High","O15068","Guanine nucleotide exchange factor DBS [OS=Homo sapiens]",4,3,3,3,1137,128,6.43,6.81,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","MCF2L","ENSG00000126217","","CDC42 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RHOB GTPase cycle","",84.3,67.3,76.1,81,80.3,75.6,{"$f":"AVERAGE(T258:V258)/AVERAGE(W258:Y258)","v":0.9611650485436892},{"$f":"LOG(Z258,2)","v":-0.0571439071036089},{"$f":"TTEST(T258:V258,W258:Y258,2,2)","v":0.5865840102210573},{"$f":"-LOG10(AB258)","v":0.2316697796906325},{"$f":"AB258*7808/AF258","v":0.7652544614546392},{"$f":"-LOG10(AD258)","v":0.11619412977442657},5985]
["High","O15069","NAC-alpha domain-containing protein 1 [OS=Homo sapiens]",1,1,2,1,1562,161,4.23,4.2,"transport","translational apparatus;nucleus;other cell component","other molecular function","NACAD","ENSG00000136274","","","",30.5,32.1,26,34.2,30.8,30.1,0.9316508937960042,-0.10213864230554516,0.3847472355034693,0.41482449199005567,0.614965489214143,0.21114925538621215,4885]
["High","O15075-1","serine/threonine-protein kinase DCLK1 [OS=Homo sapiens]",11,4,8,4,740,82.2,8.66,21.01,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","DCLK1; LOC111158544","ENSCANG00000018654; ENSCCAG00000004898; ENSCJAG00000018203; ENSG00000133083; ENSMFAG00000030114; ENSMLEG00000042752; ENSMMUG00000016791; ENSMNEG00000028724; ENSNLEG00000001363; ENSPPAG00000038110; ENSPTRG00000005778; ENSRBIG00000027120; ENSRROG00000019788; ENSSBOG00000035278","Orexin receptor pathway","","",251.2,229.8,221.6,267.3,275.7,291.5,0.8419412822049132,-0.24820847302758975,0.017789197327506768,1.7498436474247334,0.11111844218653828,0.9542138557741544,1250]
["High","O15078-1","Centrosomal protein of 290 kDa [OS=Homo sapiens]",3,6,7,6,2479,290.2,5.95,16.08,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CEP290","ENSG00000198707","Clear cell renal cell carcinoma pathways; Ciliary landscape; Joubert syndrome; Ciliopathies","Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",593.9,563,561.5,696.3,621.4,604,0.8942082531092264,-0.16131723356864394,0.08838480201506907,1.0536224065755768,0.2676914407035141,0.5723655149343256,2578]
["High","O15083","ERC protein 2 [OS=Homo sapiens]",6,7,14,1,957,110.5,6.99,27.61,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","ERC2","ENSG00000187672","Exercise-induced circadian regulation","","",97.3,64.6,75.8,66.6,48.7,79.4,1.2208525937339498,0.28788901922214016,0.3349942892386976,0.4749625964654263,0.5722238920095714,0.24243401309612173,4571]
["High","O15084","serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A [OS=Homo sapiens]",12,9,11,9,1053,112.9,6.25,28.1,"","cytosol;nucleus","","ANKRD28","ENSG00000206560","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",362,340.5,337,318.3,346.7,327.2,1.0476718403547671,0.06718689585305397,0.2410225130995446,0.6179423895485526,0.4726026575291924,0.32550384058130793,3982]
["High","O15085-2","Isoform 2 of Rho guanine nucleotide exchange factor 11 [OS=Homo sapiens]",15,16,21,16,1562,172.1,5.54,39.81,"","","","ARHGEF11","","","","",526.3,527.6,500.1,554.2,551.1,549.1,0.9393133462282398,-0.09032158701986227,0.02109629243346779,1.6757938630515041,0.12156446591920035,0.9151933536032932,1355]
["High","O15091","Mitochondrial ribonuclease P protein 3 [OS=Homo sapiens]",16,8,10,8,583,67.3,8.78,22.84,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","other molecular function","PRORP","ENSG00000100890","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",364.5,378.6,360,445.8,391.2,415,0.8810702875399361,-0.1826709798955282,0.04155762346623437,1.381349296172883,0.17454648952359222,0.7580888812861463,1859]
["High","O15111","Inhibitor of nuclear factor kappa-B kinase subunit alpha [OS=Homo sapiens]",4,2,2,2,745,84.6,6.73,8.32,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CHUK","ENSG00000213341","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Constitutive Signaling by AKT1 E17K in Cancer; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; AKT phosphorylates targets in the cytosol","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",53.5,51.7,72.5,64.6,58,53.9,1.0067988668555239,0.009775497870135255,0.9591949007756015,0.01809313867787403,0.9809291139824357,0.008362375411678655,7635]
["High","O15116","U6 snRNA-associated Sm-like protein LSm1 [OS=Homo sapiens]",29,4,6,4,133,15.2,5.22,5.98,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM1","ENSG00000175324","","mRNA decay by 5' to 3' exoribonuclease","RNA degradation",406.8,345.3,357.6,369.8,338.9,323.4,1.0751865129347933,0.10458694627606728,0.32764531912783296,0.48459603216831504,0.5652352301701545,0.24777077712838946,4526]
["High","O15118","Niemann-Pick C1 protein [OS=Homo sapiens]",5,7,10,7,1278,142.1,5.36,21.92,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","NPC1","ENSG00000141458","Irinotecan pathway; Irinotecan pathway; Irinotecan pathway; Ebola virus infection in host; Irinotecan pathway; Irinotecan pathway","LDL clearance","Lysosome; Cholesterol metabolism",516.4,498.6,473.5,456,446.7,449.4,1.1008801124177205,0.13865736568888332,0.023439798881680178,1.6300461189743918,0.12952438051532825,0.887648476164315,1413]
["High","O15120","1-acyl-sn-glycerol-3-phosphate acyltransferase beta [OS=Homo sapiens]",6,1,2,1,278,30.9,9.01,4.84,"other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","AGPAT2","ENSG00000169692","Adipogenesis; Triacylglyceride synthesis; Ciliary landscape; Congenital generalized lipodystrophy (CGL)","Neutrophil degranulation; Synthesis of PA","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fat digestion and absorption",21.7,17,13.5,18.7,16.6,18.2,0.9757009345794394,-0.03548908471862459,0.868656645329548,0.06115185359234829,0.9360296835127119,0.028710378632230946,7246]
["High","O15121","Sphingolipid delta(4)-desaturase DES1 [OS=Homo sapiens]",6,3,5,3,323,37.8,7.46,14.01,"cell organization and biogenesis;other metabolic processes;developmental processes","plasma membrane;other membranes;mitochondrion;ER/Golgi","other molecular function","DEGS1","ENSG00000143753","Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence","Neutrophil degranulation; Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",125.1,108.9,121.1,118.4,103.4,121.9,1.0331684608670353,0.047075508648674554,0.6381192726884702,0.195098138474528,0.8007771265110215,0.09648834058857719,6222]
["High","O15126-1","Secretory carrier-associated membrane protein 1 [OS=Homo sapiens]",6,2,5,2,338,37.9,7.42,13.7,"transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP1","ENSG00000085365","","Neutrophil degranulation","",308,301.9,283.4,318.7,286.6,308.3,0.9777802101576183,-0.03241788876036407,0.6030842197235633,0.21962203511160397,0.7770431662708882,0.10955485461925475,6060]
["High","O15127","Secretory carrier-associated membrane protein 2 [OS=Homo sapiens]",17,4,13,4,329,36.6,6.1,33.7,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP2","ENSG00000140497","Serotonin transporter activity; Monoamine transport","","",632.6,602.3,587.5,602.3,551.6,594.7,1.042205192725609,0.05963934804255041,0.29888948126948917,0.5244893686910661,0.5363661387617034,0.2705386473251477,4351]
["High","O15143","Actin-related protein 2/3 complex subunit 1B [OS=Homo sapiens]",30,9,23,9,372,40.9,8.35,62.02,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ARPC1B","ENSG00000130429","Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",1647.3,1583.5,1568.6,1462.1,1745.6,1690.8,0.9797693171378994,-0.029485982595146964,0.7325011642235176,0.1351916807138562,0.859538486663244,0.06573467258802454,6654]
["High","O15144","Actin-related protein 2/3 complex subunit 2 [OS=Homo sapiens]",59,17,56,17,300,34.3,7.36,116.07,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","ARPC2","ENSG00000163466","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",2960,2848.9,2908.2,2739,3446.9,3096,0.9391503894676734,-0.09057189465846162,0.4142449400807877,0.3827427876965887,0.6399731879997608,0.1938382206218492,5054]
["High","O15145","Actin-related protein 2/3 complex subunit 3 [OS=Homo sapiens]",21,4,14,4,178,20.5,8.59,26.18,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC3","ENSG00000111229","Pathogenic Escherichia coli infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",556,509.2,432.7,472.6,494.8,488.7,1.0287068195865667,0.04083187416985631,0.7223654414057892,0.14124303922524664,0.852642383446168,0.06923308309013103,6615]
["High","O15151","Protein Mdm4 [OS=Homo sapiens]",5,2,2,2,490,54.8,5,2.63,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","nucleus","other molecular function","MDM4","ENSG00000198625","Glioblastoma signaling pathways; Malignant pleural mesothelioma","Regulation of TP53 Activity through Methylation; Ub-specific processing proteases; Regulation of TP53 Degradation; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Oncogene Induced Senescence; Stabilization of p53","p53 signaling pathway; MicroRNAs in cancer",51.9,44.2,29.2,55.8,52,55.4,0.7677696078431373,-0.381254642649635,0.13557714119737996,0.8678135279372161,0.3418102416755385,0.46621492863536745,3097]
["High","O15155","BET1 homolog [OS=Homo sapiens]",25,2,3,2,118,13.3,9.06,9.82,"cell organization and biogenesis;transport","other membranes;ER/Golgi","other molecular function","BET1","ENSG00000105829","","COPI-mediated anterograde transport; COPII-mediated vesicle transport","SNARE interactions in vesicular transport",173.7,157,161.4,161,174.2,184,0.9478043143297379,-0.0773388668689994,0.33913229564397684,0.4696308502923753,0.5763920253348218,0.23928203649274712,4594]
["Medium","O15156","Zinc finger and BTB domain-containing protein 7B [OS=Homo sapiens]",1,1,1,1,539,58,5.86,2.12,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB7B","ENSG00000160685","Ectoderm differentiation; Ectoderm differentiation","","",60.7,63,61.2,91.2,72.1,89.8,0.7305412880284472,-0.4529622827064884,0.021300025238723142,1.6716198819588353,0.12210763367397232,0.9132571848769662,1362]
["High","O15160","DNA-directed RNA polymerases I and III subunit RPAC1 [OS=Homo sapiens]",34,9,31,9,346,39.2,5.5,53.07,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR1C","ENSG00000171453","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase; Cytosolic DNA-sensing pathway",816.9,849,839.5,833.5,853.4,833.6,0.9940091251735768,-8.668998852076025E-3,0.6865773514700193,0.16331052700089957,0.830616045906091,0.08059968341015032,6454]
["High","O15162","phospholipid scramblase 1 [OS=Homo sapiens]",9,2,2,2,318,35,4.94,2.44,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;transporter activity;nucleic acid binding activity;other molecular function","PLSCR1","ENSG00000188313","EGF/EGFR signaling pathway; Complement system in neuronal development and plasticity","","",58.2,68.6,57.3,71.9,64,65.9,0.9122893954410307,-0.1324365477564508,0.24538452608225236,0.610152827301661,0.47803452586083495,0.32054073550221485,4008]
["High","O15164","Transcription intermediary factor 1-alpha [OS=Homo sapiens]",29,19,35,18,1050,116.8,7.11,75.15,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function","TRIM24","ENSG00000122779","","Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",785.3,877.6,834.6,956.8,880.8,847.9,0.9299944144479613,-0.10470604347575331,0.20858326815246844,0.6807205321534777,0.4366268519395372,0.35988955930352984,3730]
["Medium","O15169","Axin-1 [OS=Homo sapiens]",1,1,1,1,862,95.6,6.96,1.89,"cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","AXIN1","ENSG00000103126","Alzheimer's disease and miRNA effects; Neural crest differentiation; Mesodermal commitment pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Wnt signaling pathway; TGF-beta signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)","Ub-specific processing proteases; Degradation of AXIN; Estrogen-dependent gene expression; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling","Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Colorectal cancer; Endometrial cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",54,49.2,47.4,54.6,42.4,49.6,1.0272851296043655,0.038836666538116085,0.7586150939537902,0.11997852051059833,0.8732517549154053,0.05886053291698509,6783]
["High","O15173","Membrane-associated progesterone receptor component 2 [OS=Homo sapiens]",52,12,38,10,223,23.8,4.88,90.01,"transport;developmental processes;signal transduction","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","PGRMC2","ENSG00000164040","Ciliary landscape","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","",670.3,641.9,618.7,687.5,654,686.9,0.9519325576809308,-0.07106872949057715,0.15512380189315142,0.8093215597765495,0.36972119816292015,0.43212564820629495,3276]
["High","O15182","Centrin-3 [OS=Homo sapiens]",34,5,6,5,167,19.5,4.74,10.29,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","CETN3","ENSG00000153140","Breast cancer pathway","","",407.1,363.5,314.3,402.5,312.1,315.7,1.0529942735125692,0.07449759059204158,0.6719389254476229,0.17267019948558573,0.8218200391439598,0.08522327316962335,6384]
["High","O15194-1","CTD small phosphatase-like protein [OS=Homo sapiens]",11,3,4,2,276,31.1,5.54,2.79,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","CTDSPL","ENSG00000144677; ENSPTRG00000014749","","","",118,111.3,103.2,137.4,143.6,135.2,0.7988947621335897,-0.32392262445942027,0.004923320649645182,2.30774187825596,0.05932297474140368,1.2267770794679178,648]
["High","O15213","WD repeat-containing protein 46 [OS=Homo sapiens]",26,15,25,15,610,68,9.67,52.8,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","WDR46","ENSG00000204221; ENSG00000206284; ENSG00000226916; ENSG00000227057; ENSG00000236222","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",623.4,643.5,626.1,645.1,621.8,692.8,0.9659641781905394,-0.04995840572807588,0.3659256857505382,0.43660710462052466,0.6004934330265241,0.22149173766313676,4758]
["High","O15226","NF-kappa-B-repressing factor [OS=Homo sapiens]",36,22,44,22,690,77.6,8.79,73.45,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","NKRF","ENSG00000186416","Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway","","",2314.6,2427.3,2320.8,2342.8,2220.8,2300.2,1.0289781170780032,0.041212301261287956,0.2646015160610049,0.5774076718074656,0.5006078598023568,0.30050233602624615,4127]
["High","O15228","Dihydroxyacetone phosphate acyltransferase [OS=Homo sapiens]",26,16,30,16,680,77.1,6.57,55.14,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","other molecular function","GNPAT","ENSG00000116906","Triacylglyceride synthesis","Peroxisomal protein import; Plasmalogen biosynthesis; Synthesis of PA","Glycerophospholipid metabolism; Peroxisome",1131.8,1167,1171.7,1077.8,1096.5,1070,1.0697222821563972,0.09723629741096503,0.007082352925150547,2.149822435439188,0.07080539262429639,1.149933664657853,781]
["High","O15230","Laminin subunit alpha-5 [OS=Homo sapiens]",11,31,40,31,3695,399.5,7.02,79.53,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;extracellular structural activity","LAMA5","ENSG00000130702","Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Malignant pleural mesothelioma","Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer",1546.7,1567.4,1567.5,1653.2,1575.2,1604.1,0.9687739265390586,-0.0457680578474734,0.10203641218119569,0.9912448205179782,0.28678916713850827,0.5424372572609396,2778]
["High","O15231-1","zinc finger protein 185 [OS=Homo sapiens]",4,3,4,2,689,73.5,7.01,8.4,"","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ZNF185","ENSG00000147394","","","",220.1,202.7,200.5,192.8,174.3,170.4,1.1596279069767441,0.21366195804669935,0.03689378012193982,1.433046844854702,0.161562891302359,0.7916583833714212,1783]
["High","O15231-2","Isoform 2 of Zinc finger protein 185 [OS=Homo sapiens]",4,2,3,1,452,48.6,5.43,4.51,"","","","ZNF185","","","","",114.8,110.4,108.8,103.1,96.4,78.2,1.2027367662945625,0.26632092554256864,0.07026376523904745,1.1532685812914019,0.23385314534803175,0.631056784412277,2346]
["High","O15234","Protein CASC3 [OS=Homo sapiens]",10,6,6,6,703,76.2,6.48,15.76,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CASC3","ENSG00000108349","","Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Nucleocytoplasmic transport; mRNA surveillance pathway",399.4,426.3,427.2,497.8,446.1,499.7,0.8678996952064284,-0.2043997775518235,0.03250485052807183,1.488051826701346,0.1525227601701832,0.8166653439974159,1664]
["High","O15235","28S ribosomal protein S12, mitochondrial [OS=Homo sapiens]",24,2,3,2,138,15.2,10.29,10.61,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS12","ENSG00000128626; ENSG00000283018","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",54,59.2,47.6,56.7,64.5,60.5,0.8849752339020364,-0.17629101305518713,0.15974939142805814,0.7965607876292782,0.3753605923172669,0.4255513242493538,3323]
["High","O15240","Neurosecretory protein VGF [OS=Homo sapiens]",29,17,38,17,615,67.2,4.78,79.58,"cell-cell signaling;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;ER/Golgi;other cell component","signal transduction activity or receptor binding","VGF","ENSG00000128564","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; NGF-stimulated transcription","",469.6,530.8,415.5,375.9,351.2,302,1.3758624040423673,0.4603361975606915,0.03159526232993438,1.5003780344139361,0.15069994396586903,0.8218869091672422,1637]
["High","O15243","Leptin receptor gene-related protein [OS=Homo sapiens]",18,3,4,3,131,14.2,6.51,5.11,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding","LEPROT","ENSG00000213625","","","",285.3,298,279.5,345.3,314.5,301,0.8980016652789341,-0.1552099745451803,0.08292626802474211,1.081307878965091,0.2582721582517696,0.587922408264672,2507]
["High","O15254","Peroxisomal acyl-coenzyme A oxidase 3 [OS=Homo sapiens]",13,5,7,5,700,77.6,7.25,11.54,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOX3","ENSG00000087008","PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","Fatty acid degradation; beta-Alanine metabolism; alpha-Linolenic acid metabolism; Propanoate metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; PPAR signaling pathway; cAMP signaling pathway; Peroxisome; Alcoholic liver disease",53.9,52.5,54.1,49.8,44.2,51.7,1.1015785861358958,0.13957241994515301,0.09923844436084045,1.0033200522474517,0.28320678858532244,0.5478963406368949,2736]
["High","O15258","Protein RER1 [OS=Homo sapiens]",14,2,5,2,196,22.9,9.54,7.25,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","RER1","ENSG00000157916","","","",236.8,198.6,206.2,200.9,184.4,208.1,1.081226828446242,0.1126692149746534,0.30351518978183334,0.5178195692564158,0.5399513788600033,0.26764534544275365,4389]
["High","O15260-1","surfeit locus protein 4 [OS=Homo sapiens]",17,4,16,4,269,30.4,7.78,29.12,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","SURF4","ENSG00000148248; ENSG00000280951; ENSGGOG00000014456; ENSNLEG00000013096; ENSPTRG00000021519","","COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation","",419.2,420.6,436.3,398.8,443.6,425.3,1.00662617338487,0.009528015088966084,0.8524058858429282,0.06935356015412865,0.9281251090031494,0.03239347799721106,7171]
["Medium","O15265","Ataxin-7 [OS=Homo sapiens]",2,1,1,1,892,95.4,9.85,2.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","","ATXN7","ENSG00000163635","","Ub-specific processing proteases; HATs acetylate histones","",16.8,24.6,20.5,18.6,16.3,22.1,1.0859649122807018,0.11897749016216068,0.5927341079567693,0.22714008124552174,0.7699331084555738,0.11354700455550311,6011]
["High","O15269","serine palmitoyltransferase 1 [OS=Homo sapiens]",31,14,50,14,473,52.7,6.01,111.29,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC1","ENSG00000090054","Sphingolipid pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",1821.6,1744.8,1756.7,1506.4,1535.7,1534.4,1.163137769037474,0.21802198841525713,6.3718248831265781E-4,3.195736168422833,0.02380440607055135,1.6233426498752517,209]
["High","O15270","Serine palmitoyltransferase 2 [OS=Homo sapiens]",18,8,17,8,562,62.9,7.78,38.64,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC2","ENSG00000100596","Sphingolipid pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",537.5,510.8,523.6,434.3,453.8,448.8,1.175779789064253,0.23361788417620344,1.2656328445839779E-3,2.8976922632739477,0.03305037207528996,1.4808236469397418,299]
["High","O15287","Fanconi anemia group G protein [OS=Homo sapiens]",12,5,6,5,622,68.5,5.47,11.98,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus","nucleic acid binding activity","FANCG","ENSG00000221829","Retinoblastoma gene in cancer; DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",51.5,44.7,37.7,53.1,70.4,47.8,0.7816695855224751,-0.3553691907596886,0.18976024307042252,0.7217947720127349,0.4124855172310298,0.38459129534936626,3592]
["High","O15294","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit [OS=Homo sapiens]",11,12,27,12,1046,116.9,6.7,58.4,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","OGT","ENSG00000147162","Ectoderm differentiation; Ectoderm differentiation; Malignant pleural mesothelioma","UCH proteinases; Regulation of necroptotic cell death; HATs acetylate histones","Other types of O-glycan biosynthesis; Insulin resistance",1059.4,1106.8,1076.6,1320.7,1282.9,1316.9,0.8271393954852695,-0.27379761164737504,2.4955691266792193E-4,3.602830395776003,0.01679776184578564,1.774748580344286,116]
["High","O15305","Phosphomannomutase 2 [OS=Homo sapiens]",38,10,42,10,246,28.1,6.77,55.91,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PMM2","ENSG00000140650","Nephrotic syndrome","Defective PMM2 causes PMM2-CDG (CDG-1a); Synthesis of GDP-mannose","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",2355.6,2218.4,2257.8,2329.4,2112,2210.9,1.0269831486854173,0.03841250930222623,0.4692226822930424,0.32862100219033835,0.683142029338817,0.16548899449477103,5363]
["High","O15318","DNA-directed RNA polymerase III subunit RPC7 [OS=Homo sapiens]",14,3,3,3,223,25.9,4.63,5.5,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","POLR3G","ENSG00000113356","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",68.3,71.2,68.3,114,91.9,87.7,0.7077656675749319,-0.49865631393900106,0.02531259183107983,1.5966633838695468,0.1341756395227911,0.8723263260535424,1473]
["High","O15320","Endoplasmic reticulum export factor CTAGE5 [OS=Homo sapiens]",25,18,32,18,804,90.9,5.22,81.02,"","","","","","","","",1587.9,1782.1,1838.2,1908,1805.5,1803.5,0.9440275512053652,-0.08309912999587317,0.28425091211549924,0.5462981330567883,0.52050448447416,0.2835755244166687,4264]
["High","O15321-1","Transmembrane 9 superfamily member 1 [OS=Homo sapiens]",5,3,3,3,606,68.8,7.17,4.2,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","TM9SF1","ENSCANG00000029500; ENSCCAG00000032112; ENSG00000100926; ENSG00000285465; ENSPPAG00000042444; ENSPTRG00000032568; ENSRBIG00000029944; ENSRROG00000042511","","","",133.8,112.4,136.6,130.8,131.9,136.4,0.9591581057379104,-0.060159449025245865,0.5260525965554878,0.27897083141309237,0.7244124645335535,0.14001408564736356,5670]
["High","O15344-1","E3 ubiquitin-protein ligase Midline-1 [OS=Homo sapiens]",26,16,36,16,667,75.2,6.8,95.44,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","MID1","ENSCANG00000031338; ENSCCAG00000029160; ENSCJAG00000000987; ENSCSAG00000015273; ENSG00000101871; ENSMFAG00000037182; ENSMLEG00000034816; ENSMMUG00000020179; ENSMNEG00000026727; ENSPANG00000006683; ENSPPAG00000038224; ENSRBIG00000037000; ENSTSYG00000003295","","Interferon gamma signaling","Ubiquitin mediated proteolysis",1465.5,1366.7,1422.3,1609.7,1718.6,1674.8,0.8503727688832924,-0.23383269607343365,0.004255474645687221,2.371051992687166,0.05622122848312321,1.2500996689097859,591]
["High","O15347","High mobility group protein B3 [OS=Homo sapiens]",13,2,5,2,200,23,8.37,4.96,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","HMGB3","ENSG00000029993","","","",133.9,138.8,148.3,213.3,158.7,108.8,0.8756239600665557,-0.19161666275742703,0.5487074680675683,0.260659128890008,0.7393111148699867,0.13117276453098745,5795]
["High","O15355","Protein phosphatase 1G [OS=Homo sapiens]",56,25,161,25,546,59.2,4.36,383.7,"protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","PPM1G","ENSG00000115241","VEGFA-VEGFR2 signaling pathway; mRNA processing","","",6359.1,5878.8,5994.4,5994.7,5335.9,5694.1,1.0709322337544867,0.09886719239490412,0.1676716383897586,0.7755403919705399,0.3844875631563099,0.41511770356070854,3405]
["High","O15357","Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [OS=Homo sapiens]",18,18,39,18,1258,138.5,6.54,88.27,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","INPPL1","ENSG00000165458","EGF/EGFR signaling pathway; Insulin signaling","Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; B cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway",1434.6,1485.7,1523.8,1608.1,1491.6,1618.7,0.9418658867412684,-0.08640644726572352,0.1308341833318775,0.8832787721213602,0.33405928824568326,0.4761764485390261,3058]
["High","O15360","Fanconi anemia group A protein [OS=Homo sapiens]",6,5,6,5,1455,162.7,6.6,5.61,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","","FANCA","ENSG00000187741","DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",28.3,26.7,41,27.2,24.6,31,1.1594202898550725,0.21340363810919336,0.4191428963495763,0.37763788988298924,0.6420772483220505,0.19241271881306193,5097]
["High","O15371","Eukaryotic translation initiation factor 3 subunit D [OS=Homo sapiens]",51,21,82,21,548,63.9,6.05,173.31,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3D","ENSG00000100353","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",2606.3,2593.6,2577.4,2622.5,2659.1,2722.2,0.9717009420525249,-0.04141572735671769,0.06732877379719547,1.1717992949032259,0.227478609177197,0.6430594357236997,2311]
["High","O15372","Eukaryotic translation initiation factor 3 subunit H [OS=Homo sapiens]",55,16,78,16,352,39.9,6.54,148.32,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3H","ENSG00000147677","Translation factors; VEGFA-VEGFR2 signaling pathway; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Measles",3787.6,4037.6,3916.7,4251.1,4263.7,4201.6,0.9233666761032996,-0.1150244277892612,0.012131550361073965,1.916083694579903,0.09047100785030135,1.04349057160011,1047]
["High","O15379","Histone deacetylase 3 [OS=Homo sapiens]",9,4,8,4,428,48.8,5.16,16.06,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","HDAC3","ENSG00000171720","Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome","Cytoprotection by HMOX1; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling","Neutrophil extracellular trap formation; Thyroid hormone signaling pathway; Alcoholism; Viral carcinogenesis",374,364.2,354.8,360.3,390.1,389.1,0.9591926283457657,-0.06010752359339248,0.23976363859348887,0.6202166792671017,0.4717929662646071,0.32624853809060733,3968]
["High","O15381-1","Nuclear valosin-containing protein-like [OS=Homo sapiens]",39,28,85,28,856,95,6.48,180.61,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","NVL","ENSG00000143748","","","Ribosome biogenesis in eukaryotes",2572.1,2805.9,2770.1,3063.6,2987.6,3018.3,0.898406747891284,-0.15455933109282446,0.01557583600294571,1.807548634124817,0.10315193173112816,0.9865226345612708,1179]
["High","O15397-1","Importin-8 [OS=Homo sapiens]",19,15,32,14,1037,119.9,5.16,74.12,"transport;signal transduction","cytosol;nucleus","other molecular function","IPO8","ENSG00000133704","","Transcriptional regulation by small RNAs","Nucleocytoplasmic transport",774.9,766.6,779.7,853.8,936.5,945.8,0.8483608055261137,-0.23725012533819867,0.009379072133648752,2.027840124005615,0.08029802107404546,1.095295157675396,912]
["High","O15400","Syntaxin-7 [OS=Homo sapiens]",39,7,19,7,261,29.8,5.55,35.83,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STX7","ENSG00000079950","","","SNARE interactions in vesicular transport; Phagosome",386.6,376,358.2,327.9,356.8,332.5,1.1018482107746754,0.13992549374071162,0.04740493397756017,1.324176453943817,0.1879825924310766,0.7258823654232996,1969]
["Low","O15417-1","Trinucleotide repeat-containing gene 18 protein [OS=Homo sapiens]",0,1,2,1,2968,314.3,8.7,2.13,"","other membranes;cytosol;mitochondrion;nucleus","other molecular function","TNRC18","ENSG00000182095","","","",131.7,128.1,121.5,124.7,151.4,140.9,0.9143884892086329,-0.12912085260591116,0.22588680658271146,0.6461091342662427,0.4576347134919074,0.3394810399270415,3854]
["Medium","O15427","Monocarboxylate transporter 4 [OS=Homo sapiens]",2,1,1,1,465,49.4,7.96,2.4,"transport","plasma membrane;other membranes;nucleus;other cell component","transporter activity","SLC16A3","ENSG00000141526","Metabolic reprogramming in colon cancer","Pyruvate metabolism; Basigin interactions; Proton-coupled monocarboxylate transport","Central carbon metabolism in cancer",108.1,114.6,107.2,67.5,49.2,51.2,1.9648600357355566,0.9744265476279004,0.000984952636131053,3.006584653118118,0.029808179003532026,1.5256645544227125,258]
["Medium","O15431","High affinity copper uptake protein 1 [OS=Homo sapiens]",6,1,2,1,190,21.1,7.42,5.3,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","SLC31A1","ENSG00000136868","Copper homeostasis","Metal ion SLC transporters","Platinum drug resistance; Mineral absorption",90.2,81.5,88.6,78.9,85.4,87.7,1.0329365079365078,0.04675157801683323,0.5019983358689473,0.2992977225444852,0.708276654583437,0.14979707269078296,5534]
["High","O15439-1","multidrug resistance-associated protein 4 [OS=Homo sapiens]",10,9,10,9,1325,149.4,8.19,16.16,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","ABCC4","ENSG00000125257","Fluoropyrimidine activity; Drug induction of bile acid pathway; Ectoderm differentiation; Pregnane X receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; TYROBP causal network in microglia; Aspirin and miRNAs; Proximal tubule transport; FOXA2 pathway; Prostaglandin synthesis and regulation","ABC-family proteins mediated transport; Platelet degranulation","Antifolate resistance; ABC transporters; cAMP signaling pathway; Bile secretion",223.4,234.6,226.7,245.1,251.4,260.2,{"$f":"AVERAGE(T322:V322)/AVERAGE(W322:Y322)","v":0.9048500066076385},{"$f":"LOG(Z322,2)","v":-0.14424943270011836},{"$f":"TTEST(T322:V322,W322:Y322,2,2)","v":0.01200443959250062},{"$f":"-LOG10(AB322)","v":1.9206581094566375},{"$f":"AB322*7808/AF322","v":0.08995265291578199},{"$f":"-LOG10(AD322)","v":1.0459860237615077},1042]
["High","O15440","Multidrug resistance-associated protein 5 [OS=Homo sapiens]",9,8,12,8,1437,160.6,8.66,25.56,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","ABCC5","ENSG00000114770","Fluoropyrimidine activity; Nuclear receptors meta-pathway; NRF2 pathway","ABC-family proteins mediated transport; Hyaluronan biosynthesis and export","Antifolate resistance; ABC transporters",203.2,186.6,193.8,175.9,168,162.2,1.1531317921359414,0.20555740890916888,0.014329546357934373,1.8437675581975157,0.09918891663364503,1.003536853186204,1128]
["High","O15446-1","DNA-directed RNA polymerase I subunit RPA34 [OS=Homo sapiens]",10,3,3,3,510,55,8.51,5.83,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytosol;mitochondrion;nucleus;other cell component","other molecular function","POLR1G","ENSG00000117877","","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase",66.7,68,57.4,198,68.1,54.9,0.5984423676012461,-0.7407157783441383,0.4011117786676283,0.39673458475171824,0.6286392548849542,0.20159850329357057,4982]
["High","O15460-1","Prolyl 4-hydroxylase subunit alpha-2 [OS=Homo sapiens]",13,6,8,6,535,60.9,5.71,16.6,"protein metabolism;other metabolic processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","P4HA2","ENSG00000072682","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","Arginine and proline metabolism; Metabolic pathways",548.1,547.3,559,580.7,593.9,579.3,0.9432692855921091,-0.08425840295967442,0.00519859558159454,2.2841139666620958,0.06076442260642241,1.2163506244790059,668]
["High","O15484","calpain-5 [OS=Homo sapiens]",28,13,18,13,640,73.1,7.64,34.33,"protein metabolism;signal transduction","other cell component","other molecular function","CAPN5","ENSG00000149260","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",977.4,922,893.4,695.3,734.1,730.9,1.2927834097116142,0.37048058921692023,1.5806693364700725E-3,2.80115897153896,0.03587751796266955,1.445177609451855,344]
["High","O15488-1","Glycogenin-2 [OS=Homo sapiens]",10,4,10,4,501,55.1,5.1,27.53,"other metabolic processes","cytosol;other cell component","other molecular function","GYG2","ENSG00000056998","Glycogen synthesis and degradation","Glycogen synthesis; Glycogen storage disease type 0 (liver GYS2); Glycogen storage disease type IV (GBE1); Glycogen breakdown (glycogenolysis)","Starch and sucrose metabolism; Metabolic pathways",822.3,820.3,870.1,776,774.1,814.3,1.0627220436474372,0.0877643074158553,0.07713050943992998,1.1127738001528433,0.24762953030714363,0.6061975660949053,2432]
["High","O15498","Synaptobrevin homolog YKT6 [OS=Homo sapiens]",34,7,37,7,198,22.4,6.92,81.66,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","YKT6","ENSG00000106636","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport","SNARE interactions in vesicular transport",1941,1888.8,1877.1,1650.7,1675.7,1691.6,1.137285771223595,0.18559481265135466,5.6245023712778338E-4,3.2499158957887424,0.022521084366634525,1.6474107024926252,195]
["High","O15504","nucleoporin-like protein 2 [OS=Homo sapiens]",17,7,10,7,423,44.8,9.19,20.54,"transport","other membranes;cytosol;nucleus","other molecular function","NUP42","ENSG00000136243","","HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus","Nucleocytoplasmic transport",337.1,356.1,352.3,377.7,322.1,364.1,0.9827051414606635,-0.02516949090024241,0.7465776747765303,0.12692500110449906,0.8664207022376855,0.06227117923571941,6728]
["High","O15511-1","Actin-related protein 2/3 complex subunit 5 [OS=Homo sapiens]",40,4,5,4,151,16.3,5.67,16.5,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","Arpc5; ARPC5","ENSDLEG00000020693; ENSG00000162704; ENSGGOG00000007894; ENSPCTG00005002795; ENSPPAG00000038421; ENSPPYG00000000425; ENSPTRG00000001767; ENSRNOG00000028062; ENSSBOG00000027275; ENSSSCG00000015560; ENSSSCG00070012419; ENSSTOG00000001001","Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton","Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Neutrophil degranulation; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",93.2,80.5,81.9,111.9,95,93.3,0.8514323784143905,-0.23203614067369394,0.10681684659594708,0.97136024724494,0.29439673075226075,0.5310670171067418,2833]
["High","O15514","DNA-directed RNA polymerase II subunit RPB4 [OS=Homo sapiens]",11,1,3,1,142,16.3,4.79,2.94,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","POLR2D","ENSG00000144231","Pyrimidine metabolism","Estrogen-dependent gene expression; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; mRNA Splicing - Major Pathway; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere","RNA polymerase; Huntington disease",32.2,25.7,15.3,38.3,23.7,18.6,0.9081885856079406,-0.1389361902439247,0.7643248394588871,0.11672202623913328,0.8764647299889837,0.057265555758840896,6809]
["High","O15523","atp-dependent rna helicase ddx3y [OS=Homo sapiens]",60,37,183,9,660,73.1,7.55,381.16,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX3Y","ENSG00000067048","Novel intracellular components of RIG-I-like receptor (RLR) pathway","","",801.4,787.8,804.1,756,809,772,1.0240907145913563,0.03434351582081065,0.3185199535349041,0.496863356299846,0.5558792573090146,0.2550195314018215,4474]
["Medium","O15525","transcription factor MafG [OS=Homo sapiens]",6,1,2,1,162,17.8,10.04,2.33,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","MAFG","ENSG00000197063","Quercetin and Nf-kB / AP-1 induced apoptosis; Nuclear receptors meta-pathway; NRF2 pathway; Ethanol metabolism production of ROS by CYP2E1","Factors involved in megakaryocyte development and platelet production","",126.2,129.5,111.9,146.3,129.3,129.7,0.9069824821120159,-0.14085340875780597,0.1816138773890023,0.7408509694537011,0.4025095528394352,0.3952238079763082,3523]
["Medium","O15527-1","N-glycosylase/DNA lyase [OS=Homo sapiens]",3,1,1,1,345,38.8,8.6,2.96,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","OGG1","ENSG00000114026","Base excision repair; DNA repair pathways, full network","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Defective OGG1 Substrate Binding; Defective OGG1 Substrate Processing","Base excision repair",140.5,133.8,129.4,131.1,147.9,144.9,0.9523472517103093,-0.0704403795745851,0.33140137728583424,0.47964569100903304,0.5690745445013841,0.24483084055550594,4547]
["High","O15530-1","3-phosphoinositide-dependent protein kinase 1 [OS=Homo sapiens]",10,5,8,5,556,63.1,7.36,12.47,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function","PDPK1","ENSG00000140992","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; Serotonin HTR1 group and FOS pathway","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of TP53 Degradation; PIP3 activates AKT signaling; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ","Platinum drug resistance; PPAR signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Thyroid hormone signaling pathway; Insulin resistance; Aldosterone-regulated sodium reabsorption; Toxoplasmosis; Proteoglycans in cancer; Chemical carcinogenesis; Endometrial cancer; Prostate cancer; Non-small cell lung cancer; Choline metabolism in cancer; Lipid and atherosclerosis",362.7,361.5,382.6,304.7,285.9,297.7,1.2459754587414165,0.3172756527112449,1.1479391106551638E-3,2.940081147310676,0.03167176175263434,1.4993277781763306,283]
["High","O15540","Fatty acid-binding protein, brain [OS=Homo sapiens]",22,2,4,2,132,14.9,5.59,9.22,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus","other molecular function","FABP7","ENSG00000164434","PPAR signaling pathway; Fatty acid transporters","Triglyceride catabolism; NOTCH3 Intracellular Domain Regulates Transcription","PPAR signaling pathway",150.3,151.9,150.2,155.7,150.9,137.6,1.0184601530841961,0.02638953644283953,0.641847023130516,0.19256846870201302,0.8037757107623206,0.09486512185793905,6235]
["High","O15541","RING finger protein 113A [OS=Homo sapiens]",22,5,10,5,343,38.8,5.69,21.61,"protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","RNF113A","ENSG00000125352","","","",438.8,417.6,449.4,456,382.5,435.2,1.0252021669152862,0.03590843309311678,0.6761424013154864,0.16996182832962428,0.8243784930467393,0.08387334691825096,6404]
["High","O15550","Lysine-specific demethylase 6A [OS=Homo sapiens]",8,9,11,9,1401,154.1,7.44,21.8,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6A","ENSG00000147050","Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Malignant pleural mesothelioma","Activation of anterior HOX genes in hindbrain development during early embryogenesis; HDMs demethylate histones","Transcriptional misregulation in cancer",255.8,262.6,259.5,308.3,259.4,276.1,0.9219009243896658,-0.11731638064490027,0.2039727639363046,0.6904278191518087,0.43055402563251316,0.36597234580856736,3699]
["Medium","O15554","intermediate conductance calcium-activated potassium channel protein 4 [OS=Homo sapiens]",3,1,1,1,427,47.7,9.83,0,"cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","KCNN4","ENSG00000104783","","Ca2+ activated K+ channels","Insulin secretion; GnRH secretion; Salivary secretion; Protein digestion and absorption",143.6,185.4,170.9,159.3,259.8,202.1,0.8047327752736637,-0.31341830270377846,0.2697735260381808,0.5690006716383974,0.5054935664281536,0.2962843674370399,4167]
["High","O43143","Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [OS=Homo sapiens]",51,42,253,42,795,90.9,7.46,499.59,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","DHX15","ENSG00000109606","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",9635.8,9617.5,9715.6,10102.2,10994.8,10322.3,0.9220097201401687,-0.11714613477060246,0.039033139019324946,1.4085665216382042,0.1671808828649968,0.776813385634545,1823]
["High","O43148-1","mRNA cap guanine-N7 methyltransferase [OS=Homo sapiens]",32,18,46,17,476,54.8,6.61,90.23,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNMT","ENSG00000101654","mRNA processing","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA surveillance pathway",2465,2650.1,2554.3,2722.4,2573.6,2665.3,0.9633351337093188,-0.053890311741487035,0.23024316208428747,0.6378132589081335,0.46166887764615216,0.33566940143351087,3894]
["High","O43149","Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",2,5,6,3,2961,330.9,5.95,4.67,"","","other molecular function","ZZEF1","ENSG00000074755","","","",210.4,227.2,247.8,222.7,222,204.4,1.0559235865043908,0.07850543568124578,0.38307782205259444,0.41671299037918763,0.6140569974515823,0.21179131529232217,4871]
["High","O43149-3","Isoform 3 of Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",2,3,3,1,1085,119.9,5.67,5.48,"","","","ZZEF1","","","","",76.1,61.5,69.2,80.3,81.9,74,0.8755292125317528,-0.1917727790822226,0.11382307175549589,0.9437696982175864,0.30435977543387394,0.5166127450073692,2920]
["High","O43150-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [OS=Homo sapiens]",7,6,8,6,1006,111.6,6.68,19.9,"other biological processes","plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","ASAP2","ENSG00000151693","Vitamin D receptor pathway","","Endocytosis; Fc gamma R-mediated phagocytosis",321.5,331.1,327.5,331.3,374.3,336.5,0.9405047500239901,-0.08849286478190149,0.20956635777314744,0.6786784345039577,0.43809748902081264,0.35842923599673987,3735]
["High","O43156","TELO2-interacting protein 1 homolog [OS=Homo sapiens]",10,9,12,9,1089,122,5.97,23.39,"other biological processes","nucleus;other cell component","","TTI1","ENSG00000101407","Fragile X syndrome; Malignant pleural mesothelioma","","mTOR signaling pathway",358,392.3,402.1,397.8,488.1,427.9,0.8771502511797838,-0.18910410505040384,0.14453245290344183,0.840034626717525,0.35610899093407183,0.4484170612491903,3169]
["High","O43157","Plexin-B1 [OS=Homo sapiens]",8,11,15,11,2135,232.2,5.49,34.98,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PLXNB1","ENSG00000164050","","RHOD GTPase cycle; G alpha (12/13) signalling events; Sema4D induced cell migration and growth-cone collapse; Sema4D mediated inhibition of cell attachment and migration","Axon guidance",386.7,398.3,376.4,337.7,384.5,365.3,1.0679540229885058,0.09484953819187415,0.17550677388963606,0.7557061167701405,0.3941204746995336,0.40437100279476357,3477]
["High","O43159","ribosomal rna-processing protein 8 [OS=Homo sapiens]",22,8,17,8,456,50.7,9.42,31.67,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RRP8","ENSG00000132275","","SIRT1 negatively regulates rRNA expression","",726.4,754.1,770.1,774.5,689.5,706.5,1.0369039391845196,0.05228224624238266,0.4083665768625191,0.3889498103612689,0.6352911400961444,0.19702720138469051,5019]
["High","O43164","E3 ubiquitin-protein ligase Praja-2 [OS=Homo sapiens]",19,8,12,7,708,78.2,4.39,16.29,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","PJA2","ENSG00000198961","","Antigen processing: Ubiquitination & Proteasome degradation","",183.2,172.7,188.2,228.4,183.8,181.4,0.9166105121293799,-0.12561926356095288,0.3593588815586457,0.44447161708177174,0.5959800652527412,0.22476826659453347,4708]
["High","O43166-1","Signal-induced proliferation-associated 1-like protein 1 [OS=Homo sapiens]",3,5,5,5,1804,199.9,8.19,7.08,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","SIPA1L1","ENSG00000197555","","Neurexins and neuroligins","Rap1 signaling pathway",488.2,468.4,423.5,450.3,470,465.8,0.9956713079864368,-0.006258537936789413,0.9253626387220553,0.033688039009884464,0.9647792072562167,0.015572064937750967,7489]
["High","O43167-1","Zinc finger and BTB domain-containing protein 24 [OS=Homo sapiens]",6,4,5,4,697,78.2,7.61,11.48,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB24","ENSG00000112365","","","",123.7,115.9,134.1,142.6,148.8,138.4,0.8694741740344348,-0.20178491904703863,0.03701163707659005,1.4316617050263256,0.16198815151009816,0.7905167504077943,1784]
["High","O43169","Cytochrome b5 type B [OS=Homo sapiens]",64,6,33,6,146,16.3,4.97,87.14,"","other membranes","other molecular function","","","","","",1012.9,930.8,979.2,929.5,1100.5,933.6,0.9862667026589281,-0.01995026717403041,0.8353195014302764,0.07814737940499526,0.9186161503052955,0.036865923465435164,7100]
["High","O43172-2","Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",37,16,46,16,521,58.3,7.42,115.97,"","","","PRPF4","","","","",1935.7,2006.6,2010,1906.1,1836.5,1918.3,1.0514759137239664,0.07241580247198863,0.05068478900333698,1.29512235709834,0.19610844030627111,0.7075037143405963,2018]
["High","O43175","D-3-phosphoglycerate dehydrogenase [OS=Homo sapiens]",65,24,440,24,533,56.6,6.71,1021.72,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PHGDH","ENSG00000092621","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",14149.2,13681.9,14178.4,13721.8,13612.2,13820.3,1.02078033158139,0.02967243660241126,0.17223049522015862,0.7638899496693343,0.39001615622940794,0.40891740216337413,3448]
["High","O43181","NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [OS=Homo sapiens]",17,3,8,3,175,20.1,10.3,11.75,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity","NDUFS4","ENSG00000164258","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",298.9,287.8,301.2,313.4,312,305.9,0.9533984752496512,-0.06884877675009704,0.037821381521060383,1.422262611503274,0.1636062863802989,0.7862000130863153,1805]
["High","O43237","Cytoplasmic dynein 1 light intermediate chain 2 [OS=Homo sapiens]",24,9,23,9,492,54.1,6.38,49.13,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYNC1LI2","ENSG00000135720","Intraflagellar transport proteins binding to dynein","COPI-mediated anterograde transport; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection",498.9,579.5,547.4,507.4,515.4,489.9,1.074766972962253,0.10402389386633705,0.20027240792342113,0.6983788805218798,0.4248103670377811,0.371804893309911,3681]
["High","O43242","26S proteasome non-ATPase regulatory subunit 3 [OS=Homo sapiens]",52,26,184,26,534,60.9,8.44,350.11,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity","PSMD3","ENSG00000108344","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Ub-specific processing proteases; Degradation of beta-catenin by the destruction complex; Degradation of AXIN; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",6136.9,6149.6,6191.1,5895.7,6381,6194.2,1.0003627327309443,0.000523217823722294,0.9882272191132107,0.005143188345942694,0.9945963040520687,2.3531589513449665E-3,7758]
["High","O43251-8","Isoform 8 of RNA binding protein fox-1 homolog 2 [OS=Homo sapiens]",13,4,13,4,451,47.3,6.62,36.56,"","","","RBFOX2","","","","",209.1,228.7,214.8,273.5,256.7,255,0.8311258278145693,-0.26686118537430725,0.005960123855067881,2.2247447152574744,0.06472412664863701,1.1889338009817219,719]
["High","O43252","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [OS=Homo sapiens]",51,23,86,22,624,70.8,6.86,180.9,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS1","ENSG00000138801","Sulfation biotransformation reaction","Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways",3408.2,3366.7,3448,3298.2,3419.5,3388.1,1.0115874052524292,0.016620979981546918,0.4179960965183431,0.3788277738911357,0.6417053719259188,0.19266432507219033,5086]
["High","O43257","zinc finger HIT domain-containing protein 1 [OS=Homo sapiens]",15,1,1,1,154,17.5,9.41,2.48,"cell organization and biogenesis","nucleus","other molecular function","ZNHIT1","ENSG00000106400","","","",17.1,16.2,19.4,14.8,13.8,12.8,1.2729468599033813,0.34817219413788897,0.027758448774318926,1.556604807222118,0.14073894027914427,0.8515857233999456,1540]
["High","O43264","Centromere/kinetochore protein zw10 homolog [OS=Homo sapiens]",29,17,52,17,779,88.8,6.27,88.63,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity","ZW10","ENSG00000086827","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",1481.7,1443.4,1512.8,1522.7,1573.8,1587.2,0.9475201229796957,-0.07777151201024408,0.04337519317491591,1.362758578031313,0.17909757181900762,0.7469103022177173,1891]
["High","O43272","Proline dehydrogenase 1, mitochondrial [OS=Homo sapiens]",23,8,13,8,600,68,7.87,30.11,"other metabolic processes;stress response;signal transduction;other biological processes","other membranes;mitochondrion;nucleus;other cell component","other molecular function","PRODH","ENSG00000100033","22q11.2 copy number variation syndrome","Proline catabolism","Arginine and proline metabolism; Metabolic pathways",305.3,294.5,292.2,235.7,307.2,256.7,1.1155577788894449,0.15776523806303963,0.22701015758389517,0.6439547098379792,0.4588390656005834,0.33833961332416407,3863]
["High","O43278","Kunitz-type protease inhibitor 1 [OS=Homo sapiens]",4,2,2,2,529,58.4,6.29,5.43,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","enzyme regulator activity","SPINT1","ENSG00000166145","","MET Receptor Activation; Signaling by MST1","Transcriptional misregulation in cancer; Prostate cancer",98.3,101.4,97.7,120.6,108.3,122.3,0.8468109339407744,-0.2398881974829396,0.017029967129391047,1.768786190295641,0.1089917896281027,0.9626062163117538,1220]
["High","O43286","Beta-1,4-galactosyltransferase 5 [OS=Homo sapiens]",8,2,2,2,388,45.1,8.15,3.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","B4GALT5","ENSG00000158470","","N-Glycan antennae elongation; Keratan sulfate biosynthesis; O-linked glycosylation of mucins","Mucin type O-glycan biosynthesis; Metabolic pathways",34.3,40.6,35,65.1,81.1,80.9,0.48392778511668866,-1.0471363197576569,0.002315006783087239,2.635447732139314,0.04223264710828308,1.374351696493851,428]
["High","O43290","U4/U6.U5 tri-snRNP-associated protein 1 [OS=Homo sapiens]",48,33,95,33,800,90.2,6.13,228.79,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","SART1","ENSG00000175467","","mRNA Splicing - Major Pathway","Spliceosome",3620.3,3839.8,3697.7,3804.8,3481.3,3661.3,1.0192191753293018,0.027464325458279946,0.5701775589904114,0.24398987962287846,0.7549510565706516,0.12208120274204963,5897]
["High","O43291","Kunitz-type protease inhibitor 2 [OS=Homo sapiens]",20,4,7,4,252,28.2,8.29,13.65,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity","SPINT2","ENSG00000167642","","MET Receptor Activation; Signaling by MST1","",323.9,318.3,321.4,344.4,360.5,342.7,0.9198167239404352,-0.12058166611212563,0.008988386126707062,2.046318279255108,0.07903301675374859,1.1021914403750732,888]
["High","O43293-1","Death-associated protein kinase 3 [OS=Homo sapiens]",26,8,16,8,454,52.5,6.89,29.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","DAPK3","ENSG00000167657; ENSPTRG00000010286","Bladder cancer","Caspase activation via Dependence Receptors in the absence of ligand","Autophagy; Pathways in cancer; Bladder cancer",487.7,438.9,416.3,419.8,395.1,385.5,1.118710429856714,0.16183665340786293,0.11239219885536242,0.9492638321090064,0.3021894933411397,0.5197206394784272,2904]
["High","O43295","SLIT-ROBO Rho GTPase-activating protein 3 [OS=Homo sapiens]",2,2,2,2,1099,124.4,6.68,6.04,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity","SRGAP3","ENSG00000196220","","CDC42 GTPase cycle; RAC1 GTPase cycle; Inactivation of CDC42 and RAC1","Axon guidance",51.2,60.7,60,63.1,69.8,61,0.8865394533264569,-0.17374325862873147,0.14426238934304558,0.8408468790923913,0.3556680568331228,0.4489551378056679,3167]
["High","O43296","Zinc finger protein 264 [OS=Homo sapiens]",3,1,1,1,627,70.5,7.49,4.98,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF264","ENSG00000083844","","Generic Transcription Pathway","",19.4,20.2,25.9,16.3,8.2,20.5,1.4555555555555555,0.5415699052077755,0.1749420274199562,0.7571058447010227,0.39398539085521145,0.40451988169878395,3467]
["High","O43298","Zinc finger and BTB domain-containing protein 43 [OS=Homo sapiens]",4,2,2,2,467,52.6,5.76,2.27,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB43","ENSG00000169155","","","",129.3,105.1,119.7,119.2,88.7,117.7,1.0875307125307125,0.12105614412466918,0.47853085867159545,0.3200900509515702,0.6906412097056963,0.1607475113995043,5410]
["High","O43301","Heat shock 70 kDa protein 12A [OS=Homo sapiens]",8,4,7,4,675,74.9,6.77,0,"","nucleus;other cell component","other molecular function","HSPA12A","ENSG00000165868","","Regulation of HSF1-mediated heat shock response","",247.3,287.5,289.4,253.4,327.5,283.3,0.9537144179588057,-0.06837076730923443,0.6290549675417101,0.2013114037486382,0.7963134219464449,0.09891596413290336,6168]
["High","O43303","centriolar coiled-coil protein of 110 kDa [OS=Homo sapiens]",6,4,4,4,1012,113.4,8.65,8.68,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cell component","","CCP110","ENSG00000103540","Joubert syndrome","Ub-specific processing proteases; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; RHOV GTPase cycle","",176,164.9,171.6,181.1,169.7,163.8,0.9959191605130201,-0.005899452453628829,0.912981930180057,0.03953781797583264,0.9587845206248669,0.018278986175170268,7435]
["High","O43310","CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",10,4,4,4,598,67.5,6.54,5.41,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","CTIF","ENSG00000134030; ENSG00000282825","","","",90.1,80.6,82,97.1,85.8,75.9,0.9764296754250388,-0.03441195304773224,0.7798986034446294,0.10796185734409652,0.8843230170920224,0.05338907105411581,6886]
["High","O43314-1","inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 [OS=Homo sapiens]",12,12,15,12,1243,140.3,8.22,33.34,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","PPIP5K2","ENSG00000145725","","Synthesis of pyrophosphates in the cytosol","Phosphatidylinositol signaling system",674.7,709,676.9,722.5,718.4,706.1,0.9597578015836051,-0.05925771253174858,0.07647636885606572,1.1164727408053243,0.24664497646764194,0.6079277255884217,2421]
["High","O43318","mitogen-activated protein kinase kinase kinase 7 [OS=Homo sapiens]",5,4,5,4,606,67.2,7.11,2.45,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","signal transduction activity or receptor binding;kinase activity;other molecular function","MAP3K7","ENSG00000135341","IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL-6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway","Downstream TCR signaling; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway","MAPK signaling pathway; NF-kappa B signaling pathway; Autophagy; AMPK signaling pathway; Wnt signaling pathway; Osteoclast differentiation; Adherens junction; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; T cell receptor signaling pathway; TNF signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Leishmaniasis; Toxoplasmosis; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",320.4,314.4,317.2,348.8,298.1,347.2,0.957650135801227,-0.06242941130017622,0.4487719832641931,0.347974263814198,0.6675579434800571,0.17551103192370315,5249]
["Low","O43323","desert hedgehog protein [OS=Homo sapiens]",2,1,1,1,396,43.6,9.28,0,"cell-cell signaling;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","DHH","ENSG00000139549","Hedgehog signaling pathway; Hedgehog signaling pathway; Somatic sex determination; Mammalian disorder of sexual development","Release of Hh-Np from the secreting cell; Activation of SMO; Class B/2 (Secretin family receptors); Ligand-receptor interactions; HHAT G278V doesn't palmitoylate Hh-Np; Transcriptional regulation of testis differentiation","Hedgehog signaling pathway",29.3,30.6,27.1,51.5,36.8,40.4,0.675990675990676,-0.5649247474846112,0.037601738684295914,1.4247920730633632,0.1633802869487938,0.7868003455137017,1797]
["High","O43324-1","Eukaryotic translation elongation factor 1 epsilon-1 [OS=Homo sapiens]",43,6,18,6,174,19.8,8.54,38.05,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EEF1E1","ENSANAG00000036153; ENSG00000124802; ENSPTRG00000017709","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","",813.7,736.6,714.1,853.7,813.5,818.1,0.911117370136402,-0.13429118091847042,0.08763173886794073,1.057338570558769,0.26654796146508813,0.574224634571577,2567]
["High","O43347","RNA-binding protein Musashi homolog 1 [OS=Homo sapiens]",25,7,21,6,362,39.1,7.85,39.55,"developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MSI1","ENSG00000135097","","Regulation of expression of SLITs and ROBOs","mRNA surveillance pathway",866.5,808.9,817,971.5,1065.2,1009.4,0.818226584813368,-0.2894276826243336,0.004813534578390404,2.3175359040502883,0.058542177551514446,1.2325311274605062,642]
["Medium","O43353-1","Receptor-interacting serine/threonine-protein kinase 2 [OS=Homo sapiens]",1,1,1,1,540,61.2,7.09,2.02,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","RIPK2","ENSG00000104312","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor (TCR) signaling pathway","Downstream TCR signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases","NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Shigellosis; Salmonella infection; Tuberculosis",34.4,37.8,27.2,48.8,48.9,40.7,0.7182080924855493,-0.47752618607443814,0.03486280288311517,1.4576376996202882,0.15725520792106484,0.8033949628370466,1731]
["High","O43379-1","Wd repeat-containing protein 62 [OS=Homo sapiens]",4,5,6,1,1518,165.8,5.91,8.62,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;nucleus","","WDR62","ENSG00000075702","","","",177.4,180.4,171.9,185.9,166.1,167,1.0206165703275532,0.02944097005214273,0.6333649357794577,0.19834598362122108,0.7989197768281108,0.09749682798270369,6190]
["High","O43390-1","heterogeneous nuclear ribonucleoprotein r [OS=Homo sapiens]",58,28,215,20,633,70.9,8.13,525.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","Hnrnpr; HNRNPR; LOC111154612","ENSAMEG00000009537; ENSCAFG00000013308; ENSCANG00000026442; ENSCATG00000035305; ENSFCAG00000019123; ENSG00000125944; ENSG00000282958; ENSGGOG00000013250; ENSLCNG00005013650; ENSMFAG00000039737; ENSMMUG00000010970; ENSMPUG00000015898; ENSNLEG00000008411; ENSRROG00000036942; ENSSSUG00005005658; ENSUAMG00000027050; ENSUMAG00000013292","mRNA Processing; mRNA processing","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","",4412.2,4619.7,4615.2,4761.6,4992.2,4991.2,0.9255408613089182,-0.11163141045717134,0.023577981519558665,1.6274933770373403,0.12973705405547148,0.886935967836179,1419]
["High","O43395","U4/U6 small nuclear ribonucleoprotein Prp3 [OS=Homo sapiens]",42,25,86,25,683,77.5,9.5,169.89,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","PRPF3","ENSG00000117360","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",3502.9,3869.3,3910.2,3873.6,3555.1,3684.2,1.0152525443403615,0.021838642827490602,0.7404765411024568,0.130488695726346,0.863446958322578,0.06376433605291418,6696]
["High","O43396","Thioredoxin-like protein 1 [OS=Homo sapiens]",52,12,49,12,289,32.2,4.96,135.55,"","cytosol;nucleus;other cell component","other molecular function","TXNL1","ENSG00000091164","","RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle","",2006.5,2021.3,2059.2,2071.4,1957.1,2049.9,1.0014148460121086,0.002039748700155325,0.9441060362863907,0.02497922563002366,0.9737886302938096,0.011535300471461007,7570]
["High","O43399","Tumor protein D54 [OS=Homo sapiens]",60,9,25,9,206,22.2,5.36,49.43,"other metabolic processes;other biological processes","other cell component","other molecular function","TPD52L2","ENSG00000101150","","","",997,904.9,914.4,993.1,939.7,867.2,1.0058214285714286,0.00837419482324741,0.9130939271578422,0.039484545633057304,0.9587731822550338,0.0182841220742829,7436]
["High","O43402","ER membrane protein complex subunit 8 [OS=Homo sapiens]",42,7,21,7,210,23.8,6.4,44.2,"cell organization and biogenesis","other membranes;cytosol;ER/Golgi;other cell component","","EMC8","ENSG00000131148","","","",639.7,649.9,588.7,585.8,572.6,592.9,1.0725175583851994,0.10100126654803722,0.09982083977926684,1.0007787807936044,0.28372810957281236,0.5470976355555309,2747]
["High","O43414-1","ERI1 exoribonuclease 3 [OS=Homo sapiens]",3,1,4,1,337,37.2,8.07,8.71,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","ERI3","ENSG00000117419; ENSMFAG00000044436; ENSMLEG00000012810; ENSMMUG00000011651; ENSMNEG00000035539; ENSNLEG00000014004; ENSPANG00000013867; ENSPPAG00000042776; ENSPTRG00000000655; ENSRBIG00000044795; ENSRROG00000036414","","","",254.1,227.5,251.8,266.2,249,263.1,0.9423101631761532,-0.08572609107363725,0.20959947128123396,0.6786098172032545,0.43804943034364957,0.3584768801026749,3736]
["High","O43422-1","52 kDa repressor of the inhibitor of the protein kinase [OS=Homo sapiens]",10,4,6,4,761,87.6,5.86,13.15,"other metabolic processes;signal transduction;other biological processes","","nucleic acid binding activity;kinase activity;other molecular function","THAP12","ENSG00000137492; ENSPTRG00000004091","","","",81.3,80,84.6,73.1,74.9,76.1,{"$f":"AVERAGE(T386:V386)/AVERAGE(W386:Y386)","v":1.0972780008924587},{"$f":"LOG(Z386,2)","v":0.1339290860856891},{"$f":"TTEST(T386:V386,W386:Y386,2,2)","v":0.011014901279001722},{"$f":"-LOG10(AB386)","v":1.9580193908579189},{"$f":"AB386*7808/AF386","v":0.0854914007817549},{"$f":"-LOG10(AD386)","v":1.068077566919192},1006]
["High","O43426","Synaptojanin-1 [OS=Homo sapiens]",6,7,8,7,1573,173,7.42,17.28,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ1","ENSG00000159082","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway","Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Clathrin-mediated endocytosis; Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",249.2,273.3,251.5,187.9,200.1,207.7,1.2993117340943425,0.3777476072882056,0.003464530701135408,2.460355585788324,0.05123306006527512,1.290449703663501,528]
["High","O43427","Acidic fibroblast growth factor intracellular-binding protein [OS=Homo sapiens]",23,8,15,8,364,41.9,6.48,25.79,"signal transduction","other membranes;mitochondrion;nucleus;other cell component","other molecular function","FIBP","ENSG00000172500","Modulators of TCR signaling and T cell activation","","",752.7,744.8,825.7,770.4,804.5,753.4,0.9978095606236309,-3.1636021313027644E-3,0.9572631280612158,0.01896866895473425,0.9801089042619948,0.008725665233750698,7626]
["High","O43432","Eukaryotic translation initiation factor 4 gamma 3 [OS=Homo sapiens]",23,32,66,25,1585,176.5,5.38,113.78,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","nucleic acid binding activity","EIF4G3","ENSG00000075151","Translation factors; Translation inhibitors in chronically activated PDGFRA cells","ISG15 antiviral mechanism","Viral myocarditis",1511.7,1655,1650.9,1667.7,1591.8,1654.6,0.9803626299831097,-0.02861260309956797,0.5739060176740982,0.24115922144758237,0.7577034470746296,0.12050073697904577,5914]
["High","O43439","Protein CBFA2T2 [OS=Homo sapiens]",3,2,4,2,604,67.1,8.05,10.01,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","other molecular function","CBFA2T2","ENSG00000078699","","","",235.7,238.9,210.3,241.9,222.5,215.1,1.0079470198675498,0.011419809291104307,0.8886758980985073,0.051256598232498944,0.9481800235519466,0.023109198724452218,7318]
["High","O43447","peptidyl-prolyl cis-trans isomerase H [OS=Homo sapiens]",52,9,51,8,177,19.2,8.07,58.75,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PPIH","ENSG00000171960","","mRNA Splicing - Major Pathway","Spliceosome",1817,1712.2,1808.4,1774.6,1707.3,1749.7,1.0202614878813365,0.02893895506171059,0.41525144814841186,0.38168884431481576,0.6405142843032003,0.19347118047841572,5062]
["Medium","O43462","Membrane-bound transcription factor site-2 protease [OS=Homo sapiens]",2,1,1,1,519,57.4,7.49,2.45,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MBTPS2","ENSG00000012174","Sterol regulatory element-binding proteins (SREBP) signaling; Type I collagen synthesis in the context of osteogenesis imperfecta; Unfolded protein response","Regulation of cholesterol biosynthesis by SREBP (SREBF); ATF6 (ATF6-alpha) activates chaperones; CREB3 factors activate genes; Assembly of active LPL and LIPC lipase complexes","Protein processing in endoplasmic reticulum",30.8,34.2,33.2,35.7,37.9,41.9,0.8502164502164502,-0.23409792198872686,0.04995385063958025,1.3014310290182658,0.19453349914904866,0.7110056013158316,2005]
["High","O43463","Histone-lysine N-methyltransferase SUV39H1 [OS=Homo sapiens]",3,1,2,1,412,47.9,8.03,7.6,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SUV39H1","ENSG00000101945","Histone modifications; Retinoblastoma gene in cancer; Interactions between LOXL4 and oxidative stress pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","PKMTs methylate histone lysines; SIRT1 negatively regulates rRNA expression","Lysine degradation; Metabolic pathways",79.9,84.7,101.8,93,117.7,107.9,0.8361581920903955,-0.2581521844540476,0.14997210776165787,0.8239895047548291,0.3626454683812402,0.4405177451133554,3229]
["High","O43464","Serine protease HTRA2, mitochondrial [OS=Homo sapiens]",22,6,12,6,458,48.8,10.07,17.97,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HTRA2","ENSG00000115317","Apoptosis modulation and signaling; Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity","","Apoptosis; Apoptosis; Parkinson disease; Pathways of neurodegeneration",36.1,31.3,30.9,35.2,37.2,31.8,0.9433781190019196,-0.0840919559379273,0.4401270495996861,0.35642193947867795,0.6593461249567055,0.18088654186058967,5212]
["High","O43482","Protein Mis18-beta [OS=Homo sapiens]",10,2,2,2,229,24.7,7.37,2.03,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","other molecular function","OIP5","ENSG00000104147","","Deposition of new CENPA-containing nucleosomes at the centromere","",72.7,77.8,83.6,100.2,88.1,100.1,0.8117198335644938,-0.30094623012880956,0.02387631633579974,1.6220326758022194,0.13018594828905333,0.8854358891154208,1432]
["High","O43488","aflatoxin B1 aldehyde reductase member 2 [OS=Homo sapiens]",18,6,11,6,359,39.6,7.17,9.95,"other metabolic processes","cytosol;ER/Golgi","other molecular function","AKR7A2","ENSG00000053371","Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II","Aflatoxin activation and detoxification","Metabolism of xenobiotics by cytochrome P450",461.7,486.9,472.4,448.9,478.2,440.2,1.039274482556864,0.055576734440360695,0.2589936715647234,0.586710847648855,0.4935861819812937,0.3066370069433619,4097]
["High","O43490-1","Prominin-1 [OS=Homo sapiens]",6,4,4,4,865,97.1,7.27,8.05,"developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","PROM1","ENSG00000007062","Extracellular vesicle-mediated signaling in recipient cells","","Transcriptional misregulation in cancer",44.3,49.6,50.4,55.4,57.4,54,0.8651079136690647,-0.20904798895346557,0.025282092386814514,1.5971869859892067,0.13410501179092915,0.8725549913320513,1472]
["High","O43491-1","band 4.1-like protein 2 [OS=Homo sapiens]",54,50,238,7,1005,112.5,5.44,509.23,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","EPB41L2","ENSG00000079819","Splicing factor NOVA regulated synaptic proteins","Neurexins and neuroligins","",9341.6,9548.1,9078,10077.3,9320.1,9736.8,0.9599611453206198,-0.05895208133239289,0.20593910410989635,0.686261180887107,0.43294898354606104,0.36356327563223323,3714]
["High","O43491-4","Isoform 4 of Band 4.1-like protein 2 [OS=Homo sapiens]",54,44,189,1,852,95.5,5.77,395.37,"","","","EPB41L2","","","","",22.5,20.1,14.3,26.8,18.9,20.7,0.8569277108433735,-0.22275458904034287,0.40583795390029387,0.39164734025316905,0.6331234253853136,0.19851161740987108,5005]
["High","O43493-1","Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",26,11,21,11,480,51.1,5.73,42.75,"","","","","","","","",1043.9,1129.9,1141.5,1079.1,988.1,1048.1,1.0641992745481978,0.08976832516604538,0.17722854507101193,0.751466327773899,0.3960505094202808,0.4022494237621757,3494]
["High","O43502","DNA repair protein RAD51 homolog 3 [OS=Homo sapiens]",5,2,2,2,376,42.2,6.74,5.99,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD51C","ENSG00000108384","DNA repair pathways, full network","Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination","Homologous recombination; Fanconi anemia pathway",38.1,42.1,43.1,48.2,49.7,47.2,0.8497587870434182,-0.23487471966390555,0.012685359374326624,1.8966972247704974,0.09256755700443203,1.0335411977970717,1070]
["High","O43504","Ragulator complex protein LAMTOR5 [OS=Homo sapiens]",11,1,3,1,91,9.6,4.87,9.14,"cell organization and biogenesis;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","LAMTOR5","ENSG00000134248","","Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","mTOR signaling pathway",98.2,84.4,74.5,106.1,69.6,79.5,1.0074451410658307,0.010701281068786641,0.9631511508819746,0.016305552083327183,0.9825299433089179,0.007654205313172298,7654]
["High","O43505","beta-1,4-glucuronyltransferase 1 [OS=Homo sapiens]",11,4,6,4,415,47.1,7.2,12.9,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B4GAT1","ENSG00000174684","","Keratan sulfate biosynthesis; Defective LARGE causes MDDGA6 and MDDGB6; O-linked glycosylation","Mannose type O-glycan biosynthesis; Metabolic pathways",353.2,359.1,356.5,494.9,464.1,520.2,0.7225527312060573,-0.4688252169301437,1.1055221935703692E-3,2.9564325344526154,0.03116215627219293,1.5063724988584286,277]
["High","O43524","Forkhead box protein O3 [OS=Homo sapiens]",2,1,1,1,673,71.2,5.16,2.2,"RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXO3","ENSG00000118689","IL-5 signaling pathway; Energy metabolism; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Kit receptor signaling pathway; Copper homeostasis; NAD metabolism, sirtuins and aging; Imatinib and chronic myeloid leukemia; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Non-small cell lung cancer; Leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; DNA damage response (only ATM dependent)","MAPK6/MAPK4 signaling; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by NODAL; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; FoxO signaling pathway; Mitophagy; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Neurotrophin signaling pathway; Prolactin signaling pathway; Alcoholic liver disease; Shigellosis; Chemical carcinogenesis; Endometrial cancer; Non-small cell lung cancer",27,28.4,30.1,32.5,23.2,27.1,1.0326086956521738,0.04629365227393486,0.7672760103573101,0.11504838023314558,0.8779148723431826,0.05654759373397674,6824]
["Medium","O43529","Carbohydrate sulfotransferase 10 [OS=Homo sapiens]",2,1,1,1,356,42.2,8.03,2.54,"cell adhesion;protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST10","ENSG00000115526","Metapathway biotransformation Phase I and II","Reactions specific to the complex N-glycan synthesis pathway","Mannose type O-glycan biosynthesis; Metabolic pathways",61.9,58.4,65.5,57.8,76.4,63.4,0.9402834008097167,-0.08883244520202455,0.5400405050089127,0.2675736652841698,0.7329456393376655,0.13492823465103373,5753]
["High","O43542","DNA repair protein XRCC3 [OS=Homo sapiens]",6,2,2,2,346,37.8,8.48,5,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","XRCC3","ENSG00000126215","Fluoropyrimidine activity; Male infertility","Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange","Homologous recombination",87.4,91.7,82.5,90.5,82.5,89,0.9984732824427481,-2.2042709267300264E-3,0.9723694899165944,0.012168676493389105,0.986776836140989,5.7810538055503985E-3,7694]
["High","O43567","E3 ubiquitin-protein ligase RNF13 [OS=Homo sapiens]",6,1,2,1,381,42.8,4.98,2.91,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RNF13","ENSG00000082996","","","",59,63.1,70.2,49.5,59,74.2,1.052545155993432,0.07388212871240883,0.7062393487169768,0.1510480890179201,0.8431677117403906,0.07408603268355199,6540]
["High","O43572","A-kinase anchor protein 10, mitochondrial [OS=Homo sapiens]",7,3,5,3,662,73.8,6.39,5.68,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","AKAP10","ENSG00000108599","G protein signaling pathways","Factors involved in megakaryocyte development and platelet production","",34.4,41.2,31.1,42.5,38.6,40.2,0.8796372629843363,-0.18501937429608542,0.20084021901388435,0.6971493137044346,0.42578344557708636,0.370811227900712,3683]
["High","O43583","density-regulated protein [OS=Homo sapiens]",22,5,19,5,198,22.1,5.3,47.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","","nucleic acid binding activity","DENR","ENSG00000139726","","","",899.8,818.8,828.4,1191.7,808.9,788.1,0.9133287911930291,-0.130793782286726,0.5791900895652833,0.2371788778950488,0.7605644499370555,0.11886397810533234,5946]
["High","O43592","Exportin-T [OS=Homo sapiens]",26,19,39,19,962,109.9,5.39,77.6,"transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPOT","ENSG00000184575","","tRNA processing in the nucleus","Nucleocytoplasmic transport",1388.5,1358.6,1363.9,1335.5,1581.2,1433.6,0.944992299381652,-0.08162552183848579,0.3300319235237109,0.4814440493959423,0.5675967530557565,0.2459600975944109,4540]
["Medium","O43593-1","lysine-specific demethylase hairless [OS=Homo sapiens]",2,1,1,1,1189,127.4,7.08,0,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HR","ENSG00000168453","","","",36.2,36.4,36.7,35.2,37.2,39.2,0.9793906810035841,-0.030043626157283176,0.5460411328189694,0.26277464102519726,0.7373727369509708,0.13231292370120087,5782]
["High","O43597","Protein sprouty homolog 2 [OS=Homo sapiens]",6,2,3,2,315,34.7,8.35,9.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","SPRY2","ENSG00000136158","Glioblastoma signaling pathways; Ectoderm differentiation; EGF/EGFR signaling pathway","EGFR downregulation; Spry regulation of FGF signaling","MicroRNAs in cancer",116.4,104.9,107.9,249.2,229.2,249,0.4525708001099808,-1.1437845900339911,5.9073689963417056E-5,4.228605900638759,0.013178496320981725,1.8801341403303995,35]
["High","O43598-1","2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [OS=Homo sapiens]",32,5,17,5,174,19.1,5.05,19.41,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","C6orf108; DNPH1","ENSG00000112667","","Purine catabolism","",790.5,746.6,735.9,825.4,796.7,732.7,0.9652624426702904,-0.05100684860753836,0.4433614648737902,0.3532420566431481,0.6624122307184375,0.1788716573758195,5226]
["High","O43602","Neuronal migration protein doublecortin [OS=Homo sapiens]",10,2,2,2,365,40.5,9.28,2.77,"cell organization and biogenesis;developmental processes;signal transduction","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DCX","ENSG00000077279","","Neurofascin interactions","",132.7,111.3,125.2,117,118.4,104.7,1.0855630696853866,0.11844354693793228,0.2726074398083738,0.5644622958834701,0.5081210050188071,0.2940328515860542,4189]
["High","O43615","Mitochondrial import inner membrane translocase subunit TIM44 [OS=Homo sapiens]",52,24,96,24,452,51.3,8.32,201.09,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus","other molecular function","TIMM44","ENSG00000104980","","Mitochondrial protein import","",3851.4,3725.3,3721.2,3735.9,3845,3829.1,0.9901752848378617,-0.014244155370006728,0.5315190677297924,0.2744811509689198,0.7266854983075152,0.13865350647505603,5711]
["High","O43617-1","Trafficking protein particle complex subunit 3 [OS=Homo sapiens]",42,9,25,9,180,20.3,4.96,40.56,"transport","other membranes;cytosol;ER/Golgi;other cell component","","TRAPPC3","ENSCANG00000028241; ENSCATG00000041647; ENSCSAG00000001096; ENSG00000054116; ENSGGOG00000004752; ENSMMUG00000022499; ENSMNEG00000014589; ENSPPAG00000041117; ENSPPYG00000001546; ENSRBIG00000043692; ENSRROG00000034420","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",1835.3,1783.1,1883,1695.5,1830.3,1640.2,1.064924506387921,0.09075115991571735,0.15259843135957468,0.816449930702123,0.36593628748635104,0.4365945222606513,3256]
["High","O43633","charged multivesicular body protein 2a [OS=Homo sapiens]",14,3,5,3,222,25.1,5.97,7.85,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","CHMP2A","ENSG00000130724","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Endocytosis; Necroptosis",242.8,202.6,200.2,233.3,197.3,196.6,1.0293367346938773,0.04171501916257179,0.7553518420491147,0.12185070735470946,0.8712937188239751,0.059835416793332534,6769]
["High","O43639","Cytoplasmic protein NCK2 [OS=Homo sapiens]",23,8,13,7,380,42.9,6.95,29.84,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NCK2","ENSG00000071051","Pathogenic Escherichia coli infection; Brain-derived neurotrophic factor (BDNF) signaling pathway; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; ErbB signaling pathway","RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Ephrin signaling; Activation of RAC1; Regulation of cortical dendrite branching","ErbB signaling pathway; Axon guidance; T cell receptor signaling pathway; Pathogenic Escherichia coli infection",452.3,432.4,428.6,453.9,401.6,426.9,1.0240954460386775,0.03435018126530768,0.5728216161659367,0.24198060172594466,0.756783617432087,0.1210282779485646,5910]
["High","O43657","Tetraspanin-6 [OS=Homo sapiens]",20,6,20,6,245,27.5,8.1,46.7,"other biological processes","plasma membrane;other membranes","","TSPAN6","ENSG00000000003","","","",801.2,639.4,674.1,580.6,513.2,596.7,1.2509316770186332,0.32300299500480495,0.06325183852269384,1.1989268464579725,0.22018294925777684,0.657216315382305,2243]
["High","O43660-1","Pleiotropic regulator 1 [OS=Homo sapiens]",37,13,32,13,514,57.2,9.17,67.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","","PLRG1","ENSG00000171566","","mRNA Splicing - Major Pathway","Spliceosome",1120,1163.2,1137.5,1135.3,1258.5,1225.6,0.9451013980217715,-0.08145897341026848,0.16390378809209183,0.7854110090379133,0.3796383202085592,0.4206299569002498,3371]
["High","O43663-1","Protein regulator of cytokinesis 1 [OS=Homo sapiens]",24,12,21,12,620,71.6,6.68,31.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","PRC1","ENSG00000198901","","RHO GTPases activate CIT","",386.7,452.5,456.6,534.7,603.1,591.2,0.7494505494505495,-0.4160948060618862,0.009552197443909886,2.0198967092555007,0.08106908439353086,1.0911447319424208,920]
["High","O43670-1","BUB3-interacting and GLEBS motif-containing protein ZNF207 [OS=Homo sapiens]",16,8,37,8,478,50.7,9.1,88.14,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","LOC111151255; Znf207; ZNF207","ENSAMEG00000005671; ENSANAG00000033773; ENSCANG00000036057; ENSCJAG00000014376; ENSECAG00000017464; ENSG00000010244; ENSGGOG00000024003; ENSMFAG00000001904; ENSMLEG00000018149; ENSMMUG00000016875; ENSMNEG00000041308; ENSNLEG00000005954; ENSOCUG00000008195; ENSPCOG00000020744; ENSPPAG00000032098; ENSPTRG00000008989; ENSRROG00000037743; ENSSBOG00000026038; ENSSTOG00000000712","","","",1258,1153.5,1156.5,1204.6,1095.8,1188.3,1.022730529996847,0.03242607250401852,0.6128786167963407,0.21262553082500962,0.7834571447193562,0.10598475455075781,6108]
["High","O43674-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [OS=Homo sapiens]",21,4,13,4,189,21.7,9.63,29.64,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB5","ENSG00000136521; ENSGGOG00000005222; ENSPTRG00000015649","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",812.2,788.3,756.4,731.5,768.9,754.3,1.0453275380316673,0.06395506044483146,0.15532034533641645,0.8087716525225047,0.37007667268438804,0.43170828924624516,3277]
["High","O43676","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [OS=Homo sapiens]",11,1,3,1,98,11.4,9.2,6.82,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB3","ENSG00000119013","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",162.9,152.8,123.9,162,139.2,155,0.9636124506795265,-0.05347506036290629,0.7027369583686431,0.15320720543036068,0.8406572959923955,0.07538101346770198,6527]
["High","O43678","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [OS=Homo sapiens]",37,3,4,3,99,10.9,9.57,6.95,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;mitochondrion","transporter activity","NDUFA2","ENSG00000131495","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",160.1,129.8,142.3,230.4,135.1,159.3,0.8235518292682927,-0.2800686477585763,0.3605364999823628,0.4430507616283146,0.5971720390034554,0.22390053515798417,4714]
["High","O43681","ATPase ASNA1 [OS=Homo sapiens]",44,10,49,10,348,38.8,4.91,98.01,"cell organization and biogenesis;transport","ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","GET3","ENSG00000198356","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",1478.1,1514.9,1554.3,1451.1,1552,1506.5,1.0083599432322157,0.012010713860399667,0.7482289353927396,0.12596550084456212,0.8674345252481828,0.061763296244931126,6735]
["High","O43683","Mitotic checkpoint serine/threonine-protein kinase BUB1 [OS=Homo sapiens]",18,14,36,14,1085,122.3,6.47,103.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","BUB1","ENSG00000169679","Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation",1142.9,1225.5,1209.6,903.3,942.2,936.9,1.2859401955146637,0.3628235496326835,7.0109975417502511E-4,3.1542201851637475,0.024996287126020988,1.6021244953452303,219]
["High","O43684","Mitotic checkpoint protein BUB3 [OS=Homo sapiens]",55,13,61,13,328,37.1,6.84,138.72,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","BUB3","ENSG00000154473","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Human T-cell leukemia virus 1 infection",2149.4,2196.2,2189.3,2190.7,2426.3,2438,0.9262792345854005,-0.11048092340595048,0.10160089518171053,0.9931024655681971,0.28607998181709193,0.5435125304874233,2773]
["High","O43687-1","A-kinase anchor protein 7 isoforms alpha and beta [OS=Homo sapiens]",12,1,1,1,104,11.5,4.94,2.61,"transport;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","AKAP7","ENSG00000118507; ENSGGOG00000008778; ENSPPAG00000039914; ENSPTRG00000018599","G protein signaling pathways","","",57.2,44.7,55.6,59.4,64.4,51.7,0.8974358974358975,-0.15611920191728185,0.3281230762530448,0.4839632254599072,0.5655595980979633,0.24752162281410375,4530]
["High","O43688","Phospholipid phosphatase 2 [OS=Homo sapiens]",7,2,6,2,288,32.6,8.35,5.2,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","PLPP2","ENSG00000141934","Triacylglyceride synthesis","Sphingolipid de novo biosynthesis","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer",345.3,369.3,351,377.2,370.8,404.1,0.9249197118305703,-0.11259995776774757,0.08249432515948106,1.0835759258341986,0.25744032407882816,0.5893234265329644,2502]
["High","O43707","Alpha-actinin-4 [OS=Homo sapiens]",70,61,472,40,911,104.8,5.44,1101.64,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","ACTN4","ENSG00000130402; ENSG00000282844","Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome","Platelet degranulation ; Nephrin family interactions","Focal adhesion; Adherens junction; Tight junction; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Amoebiasis; Viral carcinogenesis; Systemic lupus erythematosus",19781.4,19580.1,19524,19050.5,18446.7,18438.8,1.0527299056064074,0.07413533776427256,0.010595980338857528,1.9748588562198053,0.08399331419878131,1.0757552820587815,985]
["Low","O43708","maleylacetoacetate isomerase [OS=Homo sapiens]",5,1,1,1,216,24.2,8.54,0,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","GSTZ1","ENSG00000100577","Metapathway biotransformation Phase I and II","Regulation of pyruvate dehydrogenase (PDH) complex; Glutathione conjugation; Tyrosine catabolism","Tyrosine metabolism; Metabolic pathways",21,15,12,18,15.7,13.5,1.0169491525423728,0.024247546246677208,0.9322614302874228,0.030462283128551523,0.9682225655339448,0.01402479984770977,7518]
["High","O43709-1","Probable 18S rRNA (guanine-N(7))-methyltransferase [OS=Homo sapiens]",16,5,9,5,281,31.9,8.73,28.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","BUD23","ENSG00000071462; ENSGGOG00000001453","7q11.23 copy number variation syndrome","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",447.3,491,473.2,503.9,510.6,470.3,0.9506330818965517,-0.07303948679051685,0.24152012224557257,0.6170466801664585,0.4731031396119996,0.3250441698722919,3986]
["High","O43719","HIV Tat-specific factor 1 [OS=Homo sapiens]",50,32,81,32,755,85.8,4.4,178.62,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","HTATSF1","ENSG00000102241","","","",3475,3581.6,3622.6,3608.1,3296.5,3527.1,1.0237257589846334,0.0338292903945266,0.4687826535749573,0.3290284669474227,0.6833933829561737,0.1653292306287587,5356]
["High","O43739","cytohesin-3 [OS=Homo sapiens]",17,4,10,2,400,46.3,5.47,24.52,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","CYTH3","ENSG00000008256","Insulin signaling","Intra-Golgi traffic","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection",204.6,199.8,197.1,186.2,185.7,192,1.066678489093811,0.09312539445006768,0.013677014489279856,1.864008692991298,0.09629407496149424,1.0164004344818227,1109]
["High","O43741","5'-AMP-activated protein kinase subunit beta-2 [OS=Homo sapiens]",22,4,6,4,272,30.3,6.46,9.93,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PRKAB2","ENSG00000131791","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Caloric restriction and aging; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Carnitine metabolism; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy",395.5,378.5,392.1,380.5,382.8,400.6,1.0018901967522982,0.0027244034619471,0.9330752685695687,0.030083321520450713,0.9682950155490686,0.013992303740156586,7524]
["High","O43747-1","AP-1 complex subunit gamma-1 [OS=Homo sapiens]",23,16,55,16,822,91.3,6.8,113.33,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","AP1G1","ENSCANG00000031796; ENSCCAG00000037984; ENSCJAG00000015028; ENSG00000166747; ENSGGOG00000004800; ENSMFAG00000037769; ENSMLEG00000040277; ENSMMUG00000010878; ENSMNEG00000034875; ENSPANG00000016832; ENSPPAG00000031149; ENSPTRG00000008327; ENSRBIG00000018408; ENSRROG00000025423; ENSSBOG00000025975","","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","Lysosome; Human immunodeficiency virus 1 infection",2210.6,2246.9,2289.8,2055.6,2407.8,2208.9,1.0112405017759993,0.016126151995162177,0.8226700875464162,0.08477429344341429,0.9103469449493223,0.040793060908542185,7056]
["High","O43752","Syntaxin-6 [OS=Homo sapiens]",31,4,20,4,255,29.2,4.93,32.58,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STX6","ENSG00000135823","","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","SNARE interactions in vesicular transport",212.3,224.9,238.6,203.3,192.4,178.3,1.1773519163763067,0.23554561360075144,0.03183049385823643,1.4971566231369906,0.15117548421235405,0.8205186316823868,1644]
["High","O43760","Synaptogyrin-2 [OS=Homo sapiens]",32,3,6,3,224,24.8,4.94,14.02,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","SYNGR2","ENSG00000108639","","","",192.9,191.2,202.3,183.6,176.8,173.7,1.0979217375023407,0.13477521924167768,0.018241328366060294,1.7389435387573886,0.11259153508474212,0.9484942596105899,1265]
["High","O43765","Small glutamine-rich tetratricopeptide repeat-containing protein alpha [OS=Homo sapiens]",38,11,72,11,313,34,4.87,137.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","SGTA","ENSG00000104969","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",3666.7,3666,3607.7,3594,3650.2,3444.9,1.0235099306770448,0.03352510027927264,0.2625906942348807,0.580720668627542,0.49825228203789756,0.3025507035171952,4115]
["High","O43766-1","Lipoyl synthase, mitochondrial [OS=Homo sapiens]",2,1,1,1,372,41.9,8.59,2.72,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","LIAS","ENSG00000121897","","Glyoxylate metabolism and glycine degradation","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors",76.8,76.8,87.2,87.9,85.8,79,0.9529085872576177,-0.06959027218507305,0.41687920443867543,0.3799897686366872,0.6412515422098459,0.19297157740071894,5076]
["Medium","O43768","alpha-endosulfine [OS=Homo sapiens]",12,2,2,2,121,13.4,7.24,2.11,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ENSA","ENSG00000143420","","MASTL Facilitates Mitotic Progression","",144.9,143.6,139.8,202.2,114.5,107.3,1.0101415094339623,0.014557412440480847,0.9648193692480265,0.015553986429982423,0.9837176332056138,0.007129543783015842,7658]
["High","O43776","Asparagine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",42,23,123,23,548,62.9,6.25,267.5,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","NARS1","ENSG00000134440","Photodynamic therapy-induced unfolded protein response","Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",5140.3,5146.3,5304.3,5124,5367,5246.1,0.9907098512432406,-0.013465497075550266,0.6105505587025761,0.21427836700756886,0.7820175135088114,0.10678352068047754,6096]
["High","O43791","Speckle-type POZ protein [OS=Homo sapiens]",7,2,2,2,374,42.1,5.8,2.04,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SPOP","ENSG00000121067","mRNA processing; Hedgehog signaling pathway","Hedgehog 'on' state","Hedgehog signaling pathway",22.4,22.9,22.2,27.7,27,17.9,0.9297520661157025,-0.10508204605755743,0.6194885947343207,0.20796668491268835,0.7890647549242376,0.102887354772468,6130]
["High","O43795","Unconventional myosin-Ib [OS=Homo sapiens]",20,21,52,21,1136,131.9,9.38,118.64,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1B","ENSG00000128641","","","Pathogenic Escherichia coli infection",2440.2,2404.7,2549.3,2328.3,2467.2,2427.8,1.0236595461907991,0.03373597638167335,0.39621750314275944,0.4020663431578626,0.6253620910731081,0.2038684488634084,4947]
["High","O43808","peroxisomal membrane protein PMP34 [OS=Homo sapiens]",3,1,2,1,307,34.5,10.08,5.73,"other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","SLC25A17","ENSG00000100372","","Class I peroxisomal membrane protein import; Alpha-oxidation of phytanate","Peroxisome",97.3,89.7,88.7,89.1,97.2,97.9,0.9700914848698098,-0.04380728723258996,0.509568986988391,0.2927970115786403,0.7131591056471334,0.1468135683303741,5579]
["High","O43809","Cleavage and polyadenylation specificity factor subunit 5 [OS=Homo sapiens]",65,13,76,13,227,26.2,8.82,166.08,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT21","ENSG00000167005","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",3936.9,4014.7,4134.9,3657.9,4132.9,3847,1.0385553970681745,0.0545781723154272,0.3739884419368723,0.4271418194054079,0.6068374386207603,0.21692763341457966,4812]
["High","O43813","LanC-like protein 1 [OS=Homo sapiens]",22,7,17,7,399,45.3,7.75,32.8,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LANCL1","ENSG00000115365","","","Glutathione metabolism; Metabolic pathways",786,737.8,752.8,678.4,721.1,760.4,1.0540302791795917,0.07591631194171422,0.23193774568185976,0.6346285682770927,0.4631636619652074,0.3342655210143241,3910]
["High","O43815","striatin [OS=Homo sapiens]",33,19,37,19,780,86.1,5.27,61.18,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STRN","ENSG00000115808","","PIP3 activates AKT signaling; Extra-nuclear estrogen signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins","",1489,1534.5,1553,1679.3,1549.4,1603.6,0.9470645448337233,-0.07846534254288375,0.11341006636877873,0.9453483954044277,0.3037755739991164,0.5174471498408252,2915]
["High","O43818","U3 small nucleolar RNA-interacting protein 2 [OS=Homo sapiens]",28,11,31,11,475,51.8,7.85,70.76,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RRP9","ENSG00000114767","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1592.2,1628.2,1677.8,1594.1,1833.6,1732.1,{"$f":"AVERAGE(T450:V450)/AVERAGE(W450:Y450)","v":0.9493003604790884},{"$f":"LOG(Z450,2)","v":-0.07506346389658657},{"$f":"TTEST(T450:V450,W450:Y450,2,2)","v":0.30229805793309444},{"$f":"-LOG10(AB450)","v":0.5195646428706441},{"$f":"AB450*7808/AF450","v":0.5396303695339738},{"$f":"-LOG10(AD450)","v":0.2679036169136269},4374]
["High","O43819","Protein SCO2 homolog, mitochondrial [OS=Homo sapiens]",30,5,9,5,266,29.8,8.85,18.75,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO2","ENSG00000284194","","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Central carbon metabolism in cancer",174.2,188.5,174.2,156.1,173.1,160.3,1.0968335035750767,0.1333445450694803,0.08664212423646928,1.0622709084964526,0.26467202896649145,0.5772919533241797,2556]
["High","O43822","Protein C21orf2 [OS=Homo sapiens]",7,2,2,2,256,28.3,7.34,2.19,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","","CFAP410","ENSG00000160226","Ciliopathies","","",47.5,44.4,57.9,58.4,55.4,41.4,0.9652061855670105,-0.051090933728376274,0.7997903538344765,0.09702383813913311,0.8969783227146786,0.0472180524287673,6962]
["High","O43823","A-kinase anchor protein 8 [OS=Homo sapiens]",39,16,37,16,692,76.1,5.15,103.33,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","mitochondrion;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","AKAP8","ENSG00000105127","G protein signaling pathways","","",1280.2,1461.5,1406,1584.8,1430.7,1430.2,0.9329689362755023,-0.10009904835197297,0.2523270919171773,0.5980361175423887,0.4871834653039862,0.3123074598027168,4044]
["High","O43824","Putative GTP-binding protein 6 [OS=Homo sapiens]",8,4,6,4,516,56.8,9.42,7.75,"","","","","","","","",251.7,196.5,199.3,183.3,174.6,215.9,1.1284419658417568,0.17433222469261433,0.32503895106229835,0.48806459219712206,0.5622295369726242,0.25008634228022986,4514]
["High","O43829","Zinc finger and BTB domain-containing protein 14 [OS=Homo sapiens]",15,3,3,3,449,50.9,6.04,3.57,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB14","ENSG00000198081","","","",17.8,19.8,20.4,21.6,26.1,26.2,0.7848443843031122,-0.3495214641312167,0.03614461877112623,1.4419563515358902,0.16016866252267514,0.7954224509532838,1762]
["High","O43837-1","isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [OS=Homo sapiens]",17,5,13,5,385,42.2,8.46,27.69,"other metabolic processes","mitochondrion","other molecular function","IDH3B","ENSG00000101365","TCA cycle (aka Krebs or citric acid cycle)","Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids",316.4,352.1,302.4,324.4,294.1,319.8,1.0347436853884686,0.04927344442561954,0.5691949568442294,0.2447389564873059,0.7548020079890868,0.12216695315811292,5888]
["High","O43847-1","Nardilysin [OS=Homo sapiens]",36,39,93,39,1150,131.5,5,209.19,"","","","","","","","",4013.3,3966.8,4042.4,3793.3,3967,3930.7,1.0283551449833206,0.04033858887287325,0.12602461642912205,0.8995446157146023,0.3261518744045691,0.4865801212309553,3017]
["High","O43852","Calumenin [OS=Homo sapiens]",73,26,176,7,315,37.1,4.64,391.11,"","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","CALU","ENSG00000128595","NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling pathway","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",8321.8,8498.9,8143.6,10551.8,8076.1,7597.3,0.9519202904076993,-0.07108732119452554,0.6719002031971373,0.1726952275702113,0.8219014235568303,0.08518026734138118,6383]
["High","O43852-4","Isoform 4 of Calumenin [OS=Homo sapiens]",63,21,133,2,323,38.1,4.58,265.73,"","","","CALU","","","","",389.9,407,409.5,547.2,412.9,369.4,0.907408800300865,-0.14017544347636568,0.48862548087900665,0.3110238891501364,0.6987523360262425,0.15567672719623818,5460]
["High","O43861-1","Probable phospholipid-transporting ATPase IIB [OS=Homo sapiens]",2,2,2,2,1147,129.2,7.61,2.23,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP9B","ENSG00000166377","","Ion transport by P-type ATPases","",99.2,97,96.2,96,92.7,93.8,1.0350442477876105,0.04969244376252478,0.06692807325407488,1.1743916774194472,0.22671340389059289,0.6445228024864788,2305]
["High","O43865","S-adenosylhomocysteine hydrolase-like protein 1 [OS=Homo sapiens]",45,23,64,12,530,58.9,6.89,117.82,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","AHCYL1","ENSG00000168710","Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways","Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation","Cysteine and methionine metabolism; Metabolic pathways",2174.1,2096.5,2162.7,1993.9,2040.8,2104.2,1.0479564742869245,0.06757879737685786,0.07057719370850887,1.151335614056795,0.2343967369102668,0.6300484385230989,2351]
["High","O43896","Kinesin-like protein KIF1C [OS=Homo sapiens]",8,8,13,3,1103,122.9,6.9,28.39,"transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1C","ENSG00000129250","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",68.4,80.8,69.2,81.3,81.6,97.8,0.8377445339470656,-0.2554177266157039,0.10550842721114757,0.9767128508389598,0.2925460936309092,0.5338056966503989,2816]
["High","O43909","exostosin-like 3 [OS=Homo sapiens]",9,8,9,8,919,104.7,6.51,23.42,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","EXTL3","ENSG00000012232","Proteoglycan biosynthesis","XBP1(S) activates chaperone genes","Glycosaminoglycan biosynthesis; Metabolic pathways",474.2,474.2,453.1,497.7,551.4,500,0.9047188690207217,-0.14445853393875946,0.05974060196286086,1.2237304056382905,0.21545248042772175,0.6666485016690394,2165]
["High","O43913","Origin recognition complex subunit 5 [OS=Homo sapiens]",12,7,17,7,435,50.3,7.74,26.53,"DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC5","ENSG00000164815","Cell cycle; G1 to S cell cycle control; DNA replication","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle",1230.4,1250.4,1301.9,1236.4,1337.1,1322,0.9710435117443205,-0.04239215169263914,0.3773541216695535,0.4232509020431476,0.6098904951347286,0.21474813487103192,4831]
["High","O43924","Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [OS=Homo sapiens]",29,3,5,3,150,17.4,5.67,9.61,"other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PDE6D","ENSG00000156973","Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies","ARL13B-mediated ciliary trafficking of INPP5E; RAS processing","Purine metabolism; Metabolic pathways",174.1,170.4,159.1,132.5,183.4,157.9,1.0628957365977207,0.08800008447878553,0.5533231851478219,0.25702113175439883,0.743093813146576,0.1289563545301724,5814]
["High","O43929","origin recognition complex subunit 4 [OS=Homo sapiens]",22,8,13,8,436,50.3,8,29.82,"DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC4","ENSG00000115947","Cell cycle; G1 to S cell cycle control; DNA replication","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle",542,522.1,543.9,508.4,598.9,555.5,0.9670435410151552,-0.04834724655808139,0.5364621202012183,0.2704609383175607,0.730246902812258,0.136530276318669,5736]
["High","O43933","Peroxisome biogenesis factor 1 [OS=Homo sapiens]",7,10,13,10,1283,142.8,6.33,32.41,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","PEX1","ENSG00000127980","","Peroxisomal protein import","Peroxisome",630.2,591.5,572.7,566.5,598.5,566,1.0366262276140958,0.051895800832271216,0.35138008546858,0.4542228558634504,0.5876152725077474,0.23090692513562083,4669]
["High","O60216","Double-strand-break repair protein rad21 homolog [OS=Homo sapiens]",50,23,72,23,631,71.6,4.65,170.12,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RAD21","ENSG00000164754","Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin","Cell cycle",1635.9,1706.1,1695.5,1829.1,1786.6,1720.3,0.944059220389805,-0.08305073288189299,0.06089087386839003,1.2154477931733245,0.21669824209862779,0.6641446117533814,2194]
["High","O60231","Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [OS=Homo sapiens]",23,22,50,22,1041,119.2,6.8,112.69,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DHX16","ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",1961,1974.8,1979.8,2100.8,1996.7,2018.3,0.9672651165832761,-0.04801672435992798,0.10703473139103793,0.9704752764831399,0.29447751328443417,0.5309478629459597,2838]
["High","O60232","Sjoegren syndrome/scleroderma autoantigen 1 [OS=Homo sapiens]",19,2,2,2,199,21.5,5.24,7.53,"cell cycle OR cell proliferation;other biological processes","","","ZNRD2","ENSG00000173465","","","",113.7,94.6,79,109.5,73.5,69,1.140079365079365,0.18913425914524484,0.5097416197420206,0.2926499053825135,0.7130172997036361,0.1468999328764903,5582]
["High","O60244","Mediator of RNA polymerase II transcription subunit 14 [OS=Homo sapiens]",5,6,8,6,1454,160.5,8.73,11.51,"other biological processes","nucleus","other molecular function","MED14","ENSG00000180182","Vitamin D in inflammatory diseases","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",285.9,245.3,265.6,279.2,301.5,308.1,0.8964896489648965,-0.1576411693210111,0.10397491571156392,0.9830714230285975,0.290356273918416,0.5370687854436059,2796]
["High","O60256-1","Phosphoribosyl pyrophosphate synthase-associated protein 2 [OS=Homo sapiens]",37,11,32,10,369,40.9,7.44,86.18,"other metabolic processes;other biological processes","other cell component","enzyme regulator activity;other molecular function","PRPSAP2","ENSG00000141127","","","",958,951.9,984.5,933.7,1001.1,895.3,1.0227200452280838,0.032411282291942144,0.5456254191520187,0.26310540532315896,0.7373214386879476,0.13234313817270174,5778]
["High","O60264","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 [OS=Homo sapiens]",51,55,207,40,1052,121.8,8.09,440.83,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCA5","ENSG00000153147","","Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression","",8914.3,9307.6,9441.7,9522.2,9921.9,9937.6,0.9415248266778302,-0.08692895771885491,0.051627694023639634,1.2871172724963376,0.1982828504360936,0.7027148464757407,2033]
["High","O60268-1","Uncharacterized protein KIAA0513 [OS=Homo sapiens]",6,2,2,2,411,46.6,5.06,5.53,"","other cell component","","KIAA0513","ENSG00000135709","","","",145.2,161.2,147,142.8,130.2,152.6,1.0653195488721803,0.09128624023959606,0.32285902263498323,0.4909870722724458,0.5603207932282617,0.25156326077937724,4499]
["High","O60271-2","Isoform 2 of C-Jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",27,31,84,27,1311,145,5.19,198.73,"","","","SPAG9","","","","",3879,4161.3,4132,3546.6,3551.8,3381.1,1.161534424352307,0.2160319118793155,0.005932366611628749,2.2267720180469657,0.06478310280223394,1.188538255189411,715]
["High","O60281-1","zinc finger protein 292 [OS=Homo sapiens]",7,12,13,12,2723,304.6,7.39,11.68,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF292","ENSG00000188994","","","",200.9,216.3,199.9,204.6,200.9,200.2,1.018821198613175,0.026900883193460876,0.5262412325732984,0.27881512664654684,0.7244167037962471,0.14001154416292158,5672]
["High","O60282-1","kinesin heavy chain isoform 5C [OS=Homo sapiens]",46,39,132,24,957,109.4,6.19,281.38,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF5C","ENSG00000168280; ENSPPAG00000031052; ENSPTRG00000012521","Alzheimer's disease and miRNA effects; Alzheimer's disease","Insulin processing","Endocytosis; Dopaminergic synapse; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Salmonella infection; Non-small cell lung cancer",3506,3699.4,3746.9,3605.2,3293.6,3436.1,1.0597393298435398,0.0837094404582996,0.15166206369849222,0.8191230387703339,0.364698920036288,0.43806552273769994,3247]
["High","O60287","nucleolar pre-ribosomal-associated protein 1 [OS=Homo sapiens]",15,23,35,23,2271,254.2,6.47,67.46,"RNA metabolism OR transcription;other metabolic processes","nucleus","","URB1","ENSG00000142207","","","",1059.3,1026.2,1014,944,960.7,974.5,1.0765143095304253,0.10636749660814215,0.010446788230591827,1.9810172088951903,0.08383198612997018,1.076590244504907,973]
["Low","O60290-1","Zinc finger protein 862 [OS=Homo sapiens]",1,1,2,1,1169,131.6,7.23,0,"other biological processes","nucleus","other molecular function","ZNF862","ENSG00000106479","","","",13.8,16.2,16,12.9,11.6,16.5,1.1219512195121952,0.16600995143892933,0.3708744957727362,0.4307730311254345,0.6049275251709889,0.2182966539487477,4787]
["High","O60291-1","E3 ubiquitin-protein ligase MGRN1 [OS=Homo sapiens]",22,7,9,7,552,60.7,5.15,21.71,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGRN1","ENSG00000102858","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis; Hedgehog signaling pathway",194.3,207.2,197.6,166.8,210.7,213.2,1.0142204164550535,0.020371221542419073,0.8659084938989077,0.06252800023959633,0.9342287578226712,0.029546768207014424,7237]
["High","O60293","Zinc finger C3H1 domain-containing protein [OS=Homo sapiens]",11,16,21,16,1989,226.2,8.13,32.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","ZFC3H1","ENSG00000133858","","","",567.6,554.1,584.1,687.2,655.2,659.3,0.8521756506969076,-0.23077726505708152,1.7535399422464086E-3,2.7560843372819672,0.03710471509230341,1.4305708987823924,369]
["High","O60294","tRNA wybutosine-synthesizing protein 4 [OS=Homo sapiens]",3,2,3,2,686,75.6,6.73,3.23,"RNA metabolism OR transcription;other metabolic processes","other cell component","other molecular function","LCMT2","ENSG00000168806","","Synthesis of wybutosine at G37 of tRNA(Phe)","",73.9,87.2,77.6,77.9,90.5,80.4,0.9594051446945339,-0.05978791904882583,0.5753046426898085,0.24010212121797492,0.7586520267052905,0.11995737764133971,5921]
["High","O60299-1","Leucine zipper putative tumor suppressor 3 [OS=Homo sapiens]",4,2,2,2,673,71.7,7.64,6.26,"other biological processes","cytoskeleton;other cell component","","LZTS3","ENSG00000088899; ENSGGOG00000008647; ENSPTRG00000013192","","","",34,32.9,26,28,22.7,22.6,1.267394270122783,0.3418653982488409,0.10072577431730807,0.9968593853400157,0.28484854975354634,0.5453859873206435,2761]
["High","O60306","Intron-binding protein aquarius [OS=Homo sapiens]",15,18,39,17,1485,171.2,6.37,84.98,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","AQR","ENSG00000021776","","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","Spliceosome",1436,1562.6,1514.1,1522.1,1745.8,1568.6,0.9330507598469968,-0.09997252614950751,0.236080237629152,0.6269403663640037,0.4679650914974407,0.3297865425145101,3939]
["High","O60307","Microtubule-associated serine/threonine-protein kinase 3 [OS=Homo sapiens]",4,5,9,3,1309,143,8.06,4.49,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","","kinase activity;other molecular function","MAST3","ENSG00000099308","","","",269.3,292.6,288.2,343.5,317.8,310.8,0.8744985083839114,-0.19347217151684287,0.02933734876627693,1.5325791361710484,0.14479520807022142,0.8392458106740707,1582]
["High","O60313-2","Isoform 2 of Dynamin-like 120 kDa protein, mitochondrial [OS=Homo sapiens]",36,30,78,30,997,115.8,7.87,168.46,"","","","OPA1","","","","",3537.4,3650.7,3615.5,3953.8,4293.4,4203.4,0.8677172184473039,-0.20470313748611021,0.00682401337694278,2.1659601305030862,0.06928725155678704,1.1593466656458817,769]
["High","O60318","Germinal-center associated nuclear protein [OS=Homo sapiens]",13,16,20,16,1980,218.3,6.39,57.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3AP","ENSG00000160294","","","",763.5,844.9,844.1,831,810.1,877.9,0.9736006351726876,-0.03859798562764012,0.5458106207967452,0.26295801775270655,0.7374440780725016,0.13227090756045423,5779]
["High","O60331","Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [OS=Homo sapiens]",6,4,4,4,668,73.2,5.29,9.33,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIP5K1C","ENSG00000186111","B cell receptor signaling pathway; Focal adhesion; Regulation of actin cytoskeleton","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer",200.6,221,220.8,185.1,183.5,192.6,1.1446899501069137,0.19495688389741522,0.020926919278049905,1.679294700902581,0.12112482262640004,0.9167668459158499,1349]
["High","O60333","Kinesin-like protein KIF1B [OS=Homo sapiens]",14,21,40,2,1816,204.3,5.6,93.91,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1B","ENSG00000054523","Intracellular trafficking proteins involved in CMT neuropathy","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",628.2,590.7,573.8,618.4,614.4,596.1,0.980206681611898,-0.028842113926781144,0.5279451477089613,0.27741119732376934,0.7242086636176334,0.1401362840773807,5692]
["High","O60333-3","Isoform 3 of Kinesin-like protein KIF1B [OS=Homo sapiens]",21,19,33,4,1153,130.3,8.43,68.92,"","","","KIF1B","","","","",198.1,200.7,206.6,263.3,233.3,229.8,0.8334251101321585,-0.26287552746340176,0.02098360675769976,1.6781198612168504,0.12118343310955601,0.916556748163832,1352]
["High","O60337","E3 ubiquitin-protein ligase MARCH6 [OS=Homo sapiens]",2,2,2,2,910,102.5,6.28,2.75,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","MARCHF6","ENSG00000145495","","ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",141.7,133.1,136.1,146.6,134,151.4,0.9511574074074074,-0.07224398188317462,0.2896955162727616,0.538058226484423,0.5268908900670213,0.27827931030522646,4293]
["High","O60341","Lysine-specific histone demethylase 1A [OS=Homo sapiens]",59,30,92,30,852,92.8,6.52,245.15,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM1A","ENSG00000004487","Androgen receptor signaling pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects","Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Thermogenesis",3389.2,3285.5,3460.7,3322.6,3201.8,3453.3,1.0158052456979063,0.02262382927685301,0.5851405003865284,0.23273984124040575,0.7646488748147303,0.11653794620194569,5975]
["High","O60343-1","TBC1 domain family member 4 [OS=Homo sapiens]",13,14,26,14,1298,146.5,7.01,51.72,"transport;other biological processes","cytosol;other cell component","enzyme regulator activity","TBC1D4","ENSG00000136111","Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane","Thyroid hormone signaling pathway; Insulin resistance; Diabetic cardiomyopathy",632.1,656.8,654.1,691.9,672.4,683.8,0.9486841462819199,-0.07600025678867825,0.022173236764345457,1.6541709056094878,0.12527397442547708,0.9021391439890319,1382]
["High","O60344-1","Endothelin-converting enzyme 2 [OS=Homo sapiens]",5,3,8,3,883,99.7,5.1,11.83,"protein metabolism;other metabolic processes;developmental processes","plasma membrane;other membranes;ER/Golgi","other molecular function","EEF1AKMT4-ECE2","ENSG00000284917","","","",186.7,179.5,188.8,189.7,184.9,179,1.0025289017341041,3.6438284881061592E-3,0.9165607430524843,0.037838747833965396,0.9600893858000802,0.017688331593150808,7454]
["High","O60353-1","Frizzled-6 [OS=Homo sapiens]",7,4,5,4,706,79.2,7.96,6.4,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","FZD6","ENSG00000164930","Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","Class B/2 (Secretin family receptors); Ca2+ pathway; PCP/CE pathway; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",189.7,189.5,185.5,171.1,179.8,189.8,1.0443869058627704,0.06265627489929003,0.2244837988632437,0.6488149968352073,0.45585682744452716,0.3411715363140217,3845]
["High","O60427","Fatty acid desaturase 1 [OS=Homo sapiens]",4,2,4,2,444,51.9,8.87,7.33,"cell-cell signaling;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","FADS1","ENSG00000149485","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection","PPARA activates gene expression; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism",367.9,373.5,382.5,405.9,428.4,423.4,0.8936153295698499,-0.16227416006803,0.005161745734020139,2.2872033924755533,0.060697154655465727,1.2168316671849353,664]
["High","O60437","periplakin [OS=Homo sapiens]",29,51,83,51,1756,204.6,5.6,173.43,"cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PPL","ENSG00000118898","","Formation of the cornified envelope; Butyrophilin (BTN) family interactions","",3587.8,4352.4,4205.9,3553.2,3262.4,3223,1.2099396330165557,0.27493506954928104,0.05190898768700331,1.2847574405150108,0.19877654529677383,0.7016348616345154,2039]
["High","O60443","Non-syndromic hearing impairment protein 5 [OS=Homo sapiens]",9,4,7,4,496,54.5,5.17,20.01,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","transporter activity;other molecular function","GSDME","ENSG00000105928","","Regulation of TLR by endogenous ligand; Release of apoptotic factors from the mitochondria; Pyroptosis; Defective pyroptosis","",268.3,284.4,286.4,244.5,300.8,270.2,1.0289393010423054,0.04115787759810122,0.6720586313912209,0.17259283679898177,0.8218377124358109,0.08521393373978046,6385]
["High","O60447","Ecotropic viral integration site 5 protein homolog [OS=Homo sapiens]",4,3,3,3,810,92.9,6.1,9.69,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","EVI5","ENSG00000067208","","","",183,238.9,213.1,233.7,214.6,196.4,0.9849542422832326,-0.021871391602049022,0.8758025674725722,0.05759378597931672,0.9404850016264399,0.02664812596454657,7271]
["High","O60462-1","Neuropilin-2 [OS=Homo sapiens]",3,2,2,2,931,104.8,5.17,3.8,"","","","","","","","",21.6,13.2,12.9,23.5,21.7,17.6,0.7595541401273884,-0.39677529288611574,0.20665514445863814,0.6847537789514017,0.43398691983137344,0.3625233597286461,3718]
["High","O60476","mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [OS=Homo sapiens]",11,5,7,5,641,73,7.61,10.76,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","MAN1A2","ENSG00000198162","","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum",156.8,176.2,170.4,155.9,164.9,170.7,1.0242115971515766,0.034513799933036195,0.6101792321157449,0.21454257796372245,0.7817983991400945,0.10690522319174182,6094]
["High","O60481","Zinc finger protein ZIC 3 [OS=Homo sapiens]",5,3,5,2,467,50.5,8.65,8.13,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZIC3","ENSG00000156925","Mesodermal commitment pathway","POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","Signaling pathways regulating pluripotency of stem cells",381.7,377,392.3,359.3,358,364.6,1.0638691191422496,0.08932067642306511,0.009670125652442614,2.014567882710388,0.08127485586035729,1.090043792045394,929]
["High","O60488-1","Long-chain-fatty-acid--CoA ligase 4 [OS=Homo sapiens]",30,16,48,13,711,79.1,8.38,113.55,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL4","ENSG00000068366","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway",1832.1,1929.7,1940.4,1842.1,2124.2,2078.5,0.9433231868713607,-0.08417596532735043,0.29105181592689866,0.5360296867258748,0.5286188831721853,0.2768573271842464,4299]
["Medium","O60493-1","sorting nexin-3 [OS=Homo sapiens]",9,1,1,1,162,18.8,8.66,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","LOC111158258; Snx3; SNX3; Snx3_1","ENSAMEG00000008145; ENSANAG00000028701; ENSBIXG00000016466; ENSBIXG00005007963; ENSBMUG00000010256; ENSBTAG00000018801; ENSCANG00000036155; ENSCATG00000029122; ENSCCAG00000022069; ENSCGRG00015001325; ENSCHIG00000003391; ENSCJAG00000005955; ENSCSAG00000015156; ENSDLEG00000017815; ENSFCAG00000024997; ENSG00000112335; ENSLCNG00005012116; ENSMFAG00000039300; ENSMMNG00015010894; ENSMMUG00000020366; ENSMNEG00000027766; ENSMPUG00000009812; ENSMUSG00000019804; ENSNVIG00000004406; ENSOARG00000010805; ENSPANG00000017995; ENSPCOG00000020531; ENSPCTG00005013214; ENSPPAG00000032382; ENSPPYG00000016894; ENSPTRG00000018473; ENSPTRG00000046352; ENSRFEG00010011106; ENSRROG00000037899; ENSSBOG00000028606; ENSSSCG00000004385; ENSSSCG00070023370; ENSSSUG00005019212; ENSSTOG00000007274; ENSTSYG00000035289; ENSTTRG00000008868; ENSUAMG00000027552","","Ub-specific processing proteases; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking","Endocytosis",29.8,26,25.7,38.1,27.7,19.6,0.9543325526932084,-0.06743601050205056,0.8252087324027118,0.08343618494725549,0.9122511372788296,0.03988558653978746,7063]
["Medium","O60499","Syntaxin-10 [OS=Homo sapiens]",4,1,1,1,249,28.1,4.89,2.33,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","STX10","ENSG00000104915","","Retrograde transport at the Trans-Golgi-Network","Salmonella infection",49.6,51.9,56.9,51,50.8,63.1,0.960582171012735,-0.05801906335785743,0.6623473675571724,0.17891418541347312,0.8150682814635779,0.08880600718556132,6345]
["High","O60502","protein O-GlcNAcase [OS=Homo sapiens]",30,25,64,25,916,102.8,4.91,110.82,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","OGA","ENSG00000198408","","","Insulin resistance",2578.8,2568.1,2623.7,2684.2,2717.5,2570.9,0.9746632215337531,-0.03702428890237274,0.22951589025143707,0.6391872412395007,0.4609208001757255,0.33637369283510216,3888]
["High","O60504-1","Vinexin [OS=Homo sapiens]",10,5,5,5,671,75.3,9.45,8.12,"cell adhesion;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","SORBS3","ENSG00000120896","","Smooth Muscle Contraction","",141.6,129.9,130.1,144.8,147.3,165.1,0.8783902012248469,-0.18706613426370625,0.0681304126221524,1.1666589808098868,0.2293929546156817,0.6394199247892388,2319]
["High","O60506","Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",57,31,235,2,623,69.6,8.59,555.55,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","SYNCRIP","ENSG00000135316","","","",9062.4,9185,9334.2,9705.2,9694.4,9750,0.9462085243022204,-0.07976993687741035,0.002889874065548765,2.5391210824437738,0.046428264822643533,1.3332175470474315,486]
["High","O60506-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",55,29,216,1,562,62.6,7.56,498.21,"","","","SYNCRIP","","","","",98.9,100.6,117.1,124.2,127.7,113.8,0.8657369428493302,-0.2079993712041868,0.08392183487801996,1.0761250292390998,0.2598182738808802,0.5853303068175273,2522]
["High","O60507","Protein-tyrosine sulfotransferase 1 [OS=Homo sapiens]",5,2,2,2,370,42.2,9.09,2.99,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","TPST1","ENSG00000169902","","Cytosolic sulfonation of small molecules; Gamma carboxylation, hypusine formation and arylsulfatase activation; Defective F8 sulfation at Y1699","",127,141.1,157.7,129.4,120.1,125.9,1.1342567927543954,0.18174729962141978,0.14440191728581503,0.8404270404151204,0.35589967492665525,0.44867240867394087,3168]
["High","O60508","pre-mRNA-processing factor 17 [OS=Homo sapiens]",25,12,18,12,579,65.5,7.06,29.06,"RNA metabolism OR transcription;other metabolic processes","nucleus","","CDC40","ENSG00000168438","mRNA processing","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","Spliceosome",666.2,756.1,711.7,741.2,640,684.3,1.0331638828370855,0.047069115968304674,0.5908868587337683,0.22849566857994213,0.7685564872552496,0.11432420727718055,6003]
["High","O60512","beta-1,4-galactosyltransferase 3 [OS=Homo sapiens]",5,2,4,2,393,43.9,9.25,8.84,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi","other molecular function","B4GALT3","ENSG00000158850","","N-Glycan antennae elongation; Keratan sulfate biosynthesis","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways",169.5,182.8,178.5,154.8,167.7,179.2,1.0580027905122582,0.08134343260589645,0.29533380016267086,0.5296868463498406,0.5326787506745516,0.2735346275043619,4329]
["High","O60513","Beta-1,4-galactosyltransferase 4 [OS=Homo sapiens]",6,2,2,2,344,40,9.07,5.73,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B4GALT4","ENSG00000121578","","N-Glycan antennae elongation; Keratan sulfate biosynthesis","Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways",106.3,121.4,121.5,100.9,115.5,106.9,1.0801113516857408,0.11118005150335458,0.2604634995565323,0.5842531286095659,0.4955406931134026,0.30492067605469036,4104]
["High","O60518","ran-binding protein 6 [OS=Homo sapiens]",4,4,30,1,1105,124.6,5.01,33.4,"transport","nucleus;other cell component","other molecular function","RANBP6","ENSG00000137040","","","",47.3,42.6,39.1,31.5,34,41,{"$f":"AVERAGE(T514:V514)/AVERAGE(W514:Y514)","v":1.2112676056338028},{"$f":"LOG(Z514,2)","v":0.27651763519741585},{"$f":"TTEST(T514:V514,W514:Y514,2,2)","v":0.1129409016458785},{"$f":"-LOG10(AB514)","v":0.9471487494637881},{"$f":"AB514*7808/AF514","v":0.30272659116066575},{"$f":"-LOG10(AD514)","v":0.51894942943282},2913]
["High","O60524","nuclear export mediator factor NEMF [OS=Homo sapiens]",16,16,29,16,1076,122.9,6.35,56.39,"protein metabolism;other metabolic processes;transport","nucleus;other cell component","translation activity;nucleic acid binding activity","NEMF","ENSG00000165525","","","",1204.6,1214.8,1245.4,1296.5,1315.3,1244.4,0.9503656449354285,-0.07344541023976736,0.059754455039050476,1.2236297100158198,0.2151050184162776,0.6673494573713777,2169]
["High","O60547-1","GDP-mannose 4,6 dehydratase [OS=Homo sapiens]",24,8,14,8,372,41.9,7.31,28.11,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","GMDS","ENSG00000112699; ENSPPAG00000026874; ENSPPYG00000016168; ENSPTRG00000017663","","GDP-fucose biosynthesis","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",975.8,993,990,990.5,1117.4,1050.1,0.9369221025965802,-0.09399899029992514,0.14747018663135208,0.831295770127847,0.36050319887839605,0.4430908772716757,3194]
["High","O60551","Glycylpeptide N-tetradecanoyltransferase 2 [OS=Homo sapiens]",13,6,24,2,498,56.9,7.58,43.67,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NMT2","ENSG00000152465","","Membrane binding and targetting of GAG proteins; Inactivation, recovery and regulation of the phototransduction cascade","",113.9,106.5,113.9,116.3,107.7,115.2,0.9855542452830189,-0.020992814945795756,0.6783869274895453,0.16852252952176666,0.8254394779240096,0.0833147641543217,6417]
["High","O60563","Cyclin-T1 [OS=Homo sapiens]",17,10,15,10,726,80.6,8.78,34.59,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","CCNT1","ENSG00000129315","Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins","Transcriptional misregulation in cancer",1130.4,1094.3,1098.9,1003.2,929,1013.6,1.1282503903863126,0.17408727773790283,0.012159196439487466,1.9150951251806965,0.0905042953284253,1.0433308087156188,1049]
["High","O60566","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta [OS=Homo sapiens]",29,25,53,25,1050,119.5,5.27,104.76,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","BUB1B","ENSG00000156970","Regulation of sister chromatid separation at the metaphase-anaphase transition","Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Human T-cell leukemia virus 1 infection",2318.9,2390.1,2402.7,2305.4,2115.5,2134.9,1.0847951432319474,0.11742262446920507,0.04786394858069904,1.3199914767198013,0.18903475494086905,0.7234583413748381,1977]
["High","O60568","Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [OS=Homo sapiens]",29,18,53,18,738,84.7,6.05,89.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi","other molecular function","PLOD3","ENSG00000106397","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway","Collagen biosynthesis and modifying enzymes","Lysine degradation; Other types of O-glycan biosynthesis; Metabolic pathways",1633.2,1679.7,1653.2,1689,1710.3,1655.7,0.9824134520276955,-0.02559777945535314,0.22787774419655532,0.6422980883545418,0.45975954177951006,0.3374692487148178,3870]
["High","O60573","eukaryotic translation initiation factor 4E type 2 [OS=Homo sapiens]",42,10,20,10,245,28.3,8.88,48.7,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF4E2","ENSG00000135930","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance","ISG15 antiviral mechanism","EGFR tyrosine kinase inhibitor resistance; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Longevity regulating pathway; Insulin signaling pathway",1113.5,1075.8,1095.9,1109.4,1113.3,1111.1,0.9854220409142722,-0.021186354146441124,0.21309140233115006,0.6714340725545197,0.44191704366576884,0.3546592484326037,3765]
["High","O60583-2","Isoform 2 of Cyclin-T2 [OS=Homo sapiens]",16,9,15,9,663,73.6,9.14,33.54,"","","","CCNT2","","","","",784.5,809.4,765.5,651.4,596.3,623.7,1.2607673399593888,0.3343020675331014,1.3307657195258827E-3,2.8758983950683934,0.03330326518608363,1.4775131844282008,312]
["High","O60610-1","Protein diaphanous homolog 1 [OS=Homo sapiens]",38,45,105,44,1272,141.3,5.41,228.5,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH1","ENSG00000131504","Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway","RHOC GTPase cycle; RHOA GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility","Focal adhesion; Regulation of actin cytoskeleton; AGE-RAGE signaling pathway in diabetic complications; Shigellosis",5228.5,5448.1,5544.2,5340.7,5225.3,5411.3,1.0152403722781698,0.021821345969552427,0.49419584882309775,0.30610090693230807,0.702600361910187,0.1532916308383902,5492]
["High","O60613-1","selenoprotein F [OS=Homo sapiens]",15,2,6,2,162,17.8,5.03,5.79,"","","","","","","","",65,71.8,64.3,59,62.4,58.4,1.1184649610678532,0.1615200607909046,0.05801329206982613,1.236472489002451,0.21146955391279293,0.6747521508396525,2142]
["High","O60636","tetraspanin-2 [OS=Homo sapiens]",5,1,1,1,221,24.1,7.77,0,"cell organization and biogenesis;stress response;developmental processes","plasma membrane;other membranes;nucleus;other cell component","","TSPAN2","ENSG00000134198","","","",25.4,28.6,20.6,24.7,18,24.5,1.1101190476190474,0.15071439747647727,0.4839659674572111,0.31518517692004405,0.6947612196922052,0.15816443107657976,5439]
["High","O60637","Tetraspanin-3 [OS=Homo sapiens]",12,4,5,4,253,28,5.81,9.62,"","plasma membrane;other membranes","","TSPAN3","ENSG00000140391","","","",216.2,214.6,218.1,170.1,154.5,174.9,1.299099099099099,0.37751148800335405,0.001336443922681044,2.8740492595644773,0.03333851165589007,1.4770537924522902,313]
["High","O60645","exocyst complex component 3 [OS=Homo sapiens]",17,12,20,12,756,86.8,6.11,44.52,"","","","","","","","",814.3,845.1,883,820.4,829.9,838.2,1.021659634317862,0.03091464278413727,0.4307341183824933,0.3657907264765691,0.65127265614456,0.1862371554123164,5164]
["High","O60664-1","Perilipin-3 [OS=Homo sapiens]",59,23,111,23,434,47,5.44,261.52,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","PLIN3","ENSG00000105355","","Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle; Lipophagy; Chaperone Mediated Autophagy","",4204.2,4295.3,4149.8,4218.7,3908.9,4018,1.0414718087208537,0.05862378804003184,0.1689941883785801,0.7721282302887633,0.3859334960105158,0.4134875264267225,3419]
["High","O60671-1","Cell cycle checkpoint protein RAD1 [OS=Homo sapiens]",14,2,4,2,282,31.8,4.83,6.33,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD1","ENSCCAG00000029737; ENSG00000113456; ENSGGOG00000004219; ENSMFAG00000012657; ENSMMUG00000045918; ENSPANG00000024799; ENSPPAG00000028406; ENSPPYG00000015389; ENSPTRG00000016783","miRNA regulation of DNA damage response; ATR signaling; DNA damage response","Presynaptic phase of homologous DNA pairing and strand exchange; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","Cellular senescence",48,48.9,42.6,54,56.3,49.3,0.8740601503759399,-0.19419552950579583,0.07832649278660851,1.1060913193596464,0.25002994917327853,0.6020079674012776,2446]
["High","O60674","Tyrosine-protein kinase JAK2 [OS=Homo sapiens]",1,1,2,1,1132,130.6,7.21,2.52,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK2","ENSG00000096968","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Mesodermal commitment pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; IL-6 signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; Overview of interferons-mediated signaling pathway; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 distal deletion syndrome; CCL18 signaling pathway; EPO receptor signaling; Notch signaling pathway; Type II interferon signaling (IFNG); Serotonin receptor 2 and STAT3 signaling","Potential therapeutics for SARS; Signaling by BRAF and RAF1 fusions; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Signaling by SCF-KIT; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Interleukin-4 and Interleukin-13 signaling; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; RMTs methylate histone arginines; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; RAF activation; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; IL-6-type cytokine receptor ligand interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; PI3K-Akt signaling pathway; Necroptosis; Signaling pathways regulating pluripotency of stem cells; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Cholinergic synapse; Prolactin signaling pathway; Adipocytokine signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis B; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",25.1,20.6,24.8,27.6,30.6,25.2,0.8453237410071942,-0.24242412615850778,0.1140330292917486,0.9429693384746047,0.30481680681614964,0.515961090789519,2921]
["High","O60678","protein arginine N-methyltransferase 3 [OS=Homo sapiens]",18,8,22,8,531,59.8,5.35,43.19,"","","","","","","","",726.6,721.6,730.4,737.2,737.3,734.9,0.9860595636824476,-0.02025329855412381,0.018288510493889264,1.73782166415872,0.11270456979975325,0.9480584743835261,1267]
["High","O60684","Importin subunit alpha-7 [OS=Homo sapiens]",44,20,107,12,536,60,4.98,265.21,"transport;other biological processes","nucleus;other cell component","other molecular function","KPNA6","ENSG00000025800","","Assembly of the ORC complex at the origin of replication","Nucleocytoplasmic transport; Influenza A; Chemical carcinogenesis",4997.5,5108,5107.3,4905,5048.5,4890.7,1.024831247221137,0.03538636939847983,0.12006610332188866,0.9205795839216209,0.31596768949690146,0.5003573255798274,2967]
["High","O60701","UDP-glucose 6-dehydrogenase [OS=Homo sapiens]",53,21,75,21,494,55,7.12,177.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus","other molecular function","UGDH","ENSG00000109814","Glucuronidation","Formation of the active cofactor, UDP-glucuronate","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",3189.8,3222.9,3286.8,3076.6,3284.9,3283.3,1.0056714499004646,0.008159057610925563,0.8194018092517583,0.08650308145294296,0.9089202055175066,0.041474241997555686,7039]
["High","O60716-1","Catenin delta-1 [OS=Homo sapiens]",46,35,142,35,968,108.1,6.23,291.16,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","CTNND1","ENSG00000198561","VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency","VEGFR2 mediated vascular permeability; Adherens junctions interactions; InlA-mediated entry of Listeria monocytogenes into host cells","Rap1 signaling pathway; Adherens junction; Leukocyte transendothelial migration",5977.6,6348.4,6118.4,6556.4,6110.7,6218.4,0.9766434566201584,-0.03409612148340861,0.4416830153462269,0.3548893009526916,0.6610429334528157,0.1797703330164311,5217]
["High","O60725","protein-s-isoprenylcysteine O-methyltransferase [OS=Homo sapiens]",6,2,3,2,284,31.9,7.96,5.94,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ICMT","ENSG00000116237","Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome","RAS processing; Gamma carboxylation, hypusine formation and arylsulfatase activation","Terpenoid backbone biosynthesis",337.5,324.9,333.3,344.4,350.4,349.8,0.9531878230901781,-0.06916757357280111,0.017362649958762518,1.760383990297851,0.11003861272566375,0.9584548934676224,1232]
["Medium","O60729-1","Dual specificity protein phosphatase CDC14B [OS=Homo sapiens]",2,1,1,1,498,56.8,9.03,1.72,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CDC14B","ENSG00000081377; ENSPPYG00000019417; ENSPTRG00000021155","Cell cycle; Cell cycle","MAPK6/MAPK4 signaling","Cell cycle",64,56,56.8,82.5,87.8,66.2,0.7475687103594081,-0.4197219088353259,0.046337579165109416,1.33406665899441,0.18601738720883,0.730446459997501,1945]
["High","O60749","Sorting nexin-2 [OS=Homo sapiens]",30,15,58,13,519,58.4,5.12,116.69,"cell organization and biogenesis;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX2","ENSG00000205302","","Golgi Associated Vesicle Biogenesis","Endocytosis",2866,2904.7,2936.1,2761.6,2871.4,2864.9,1.0245825439226162,0.035036217546530274,0.1641743507750162,0.7846946924479241,0.38003952886194087,0.4201712289784901,3373]
["High","O60762","Dolichol-phosphate mannosyltransferase subunit 1 [OS=Homo sapiens]",30,6,23,6,260,29.6,9.57,40.23,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DPM1","ENSG00000000419","VEGFA-VEGFR2 signaling pathway","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","N-Glycan biosynthesis; Metabolic pathways",888.2,861.9,893.7,879.8,909.8,925.2,0.9738470605569471,-0.038232875250095714,0.22598881205253443,0.6459130607823299,0.4577226055787779,0.33939763851067023,3855]
["High","O60763-1","General vesicular transport factor p115 [OS=Homo sapiens]",42,38,134,38,962,107.8,4.91,304.95,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","USO1","ENSG00000138768","","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization","",5579.2,5919.5,6040.4,6021.5,6021.1,5974.7,0.9734588423348669,-0.03880811153974729,0.3152252663830605,0.5013789795994705,0.5521038312963069,0.2579792390850541,4458]
["High","O60784","Target of Myb protein 1 [OS=Homo sapiens]",25,10,19,10,492,53.8,4.7,26.27,"transport;signal transduction","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","TOM1","ENSG00000100284","","Neutrophil degranulation","",422.4,451.4,436.7,426.8,337.5,362.5,1.1630280440184595,0.2178858848408493,0.09306862515476501,1.0311967016035188,0.2742188019654359,0.5619027708816913,2650]
["High","O60825-1","6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",41,17,41,1,505,58.4,8.38,68.77,"other metabolic processes;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PFKFB2","ENSG00000123836; ENSGGOG00000012227; ENSPPAG00000041619; ENSPTRG00000001925","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects","Regulation of glycolysis by fructose 2,6-bisphosphate metabolism","Fructose and mannose metabolism; Metabolic pathways; AMPK signaling pathway; Thyroid hormone signaling pathway",1343.1,1282.5,1286.8,1165.5,1261,1257.1,1.0621131501791725,0.08693746906745785,0.10698403875596213,0.9706810110743924,0.29444179577248936,0.5310005422116093,2837]
["High","O60825-2","Isoform 2 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",45,17,40,1,471,54.4,7.56,67.1,"","","","PFKFB2","","","","",63.3,50.3,62.6,48.7,51.2,44.8,1.217691776088459,0.28414900238868906,0.08519088778014303,1.0696068559192151,0.26198127285835243,0.5817297521343019,2539]
["High","O60826","Coiled-coil domain-containing protein 22 [OS=Homo sapiens]",16,8,11,8,627,70.7,6.74,31.95,"transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","CCDC22","ENSG00000101997","","Neddylation","",520.4,556.9,546.8,599.8,537.1,562.6,0.955634010002942,-0.06546989618994628,0.30159424112748967,0.5205769554761082,0.5388667814012448,0.2685185877878945,4370]
["High","O60828","Polyglutamine-binding protein 1 [OS=Homo sapiens]",42,9,24,9,265,30.5,6.33,63.4,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PQBP1","ENSG00000102103","","mRNA Splicing - Major Pathway","Spliceosome",1122.5,1128.4,1172.7,1277.1,982.8,902.9,1.0824585810041736,0.11431182299071654,0.4913240272728909,0.30863199699508315,0.7004305285643111,0.15463493326523295,5477]
["High","O60830-1","Mitochondrial import inner membrane translocase subunit Tim17-B [OS=Homo sapiens]",33,4,14,4,172,18.3,9.03,34.75,"cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity","TIMM17B","ENSG00000126768; ENSGGOG00000011427; ENSNLEG00000007902; ENSPPAG00000036547; ENSPPYG00000020323; ENSPTRG00000021872","","Mitochondrial protein import","",463,470.5,457.8,459.2,464.2,464.2,1.0026664744883251,0.003841789777006978,0.7756694559645715,0.11032330971246357,0.882732416873834,0.054170924380239044,6861]
["High","O60831","PRA1 family protein 2 [OS=Homo sapiens]",16,3,6,3,178,19.2,9.19,8.51,"transport","other membranes;other cytoplasmic organelle","","PRAF2","ENSG00000243279","","","",312.8,304.7,283.3,287.7,253.4,299.5,1.071615512729003,0.09978737092825521,0.287980152279113,0.5406374429792812,0.5248713886543683,0.2799471004804639,4284]
["High","O60832-1","H/ACA ribonucleoprotein complex subunit 4 [OS=Homo sapiens]",45,21,88,21,514,57.6,9.42,241.12,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DKC1","ENSG00000130826; ENSGGOG00000001045; ENSPTRG00000022449","","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","Ribosome biogenesis in eukaryotes",3886,3997,4008.6,4060.1,4297.8,4232.3,0.9445123985321917,-0.08235836001696323,0.0451521254962988,1.3453218008413572,0.1832369001429839,0.7369870638845161,1924]
["High","O60841","Eukaryotic translation initiation factor 5B [OS=Homo sapiens]",39,50,196,49,1220,138.7,5.49,410.84,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","EIF5B","ENSG00000158417","Translation factors; Ciliary landscape","GTP hydrolysis and joining of the 60S ribosomal subunit","",8518.7,9642.2,9506.7,9088.2,8914,9221.6,1.0163019122973282,0.023329046471142943,0.7060842459163448,0.15114347833375252,0.8432404087052341,0.07404858991946729,6538]
["High","O60858","E3 ubiquitin-protein ligase TRIM13 [OS=Homo sapiens]",15,5,5,5,407,47,6.01,7.74,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","TRIM13","ENSG00000204977","","ER Quality Control Compartment (ERQC)","",71.5,71.4,68.6,65.2,58.5,61.8,1.1401617250673854,0.18923847649914644,0.01584506110740198,1.8001060815884609,0.10387761303660341,0.9834780384126028,1191]
["High","O60870","DNA/RNA-binding protein KIN17 [OS=Homo sapiens]",33,13,23,12,393,45.3,8.95,49.7,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","KIN","ENSG00000151657","","Protein methylation","",972.3,994,1010.9,1150.4,1039.2,1125.1,0.8981808308444202,-0.1549221627284634,0.03376802309485027,1.471494363827985,0.1552772228060017,0.8088922450772833,1698]
["High","O60879","Protein diaphanous homolog 2 [OS=Homo sapiens]",11,11,15,11,1101,125.5,6.58,30.96,"cell organization and biogenesis;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH2","ENSG00000147202","","RHOF GTPase cycle","Regulation of actin cytoskeleton",739.8,726.1,722.9,807.1,752.3,750,0.9477786438035853,-0.07737794164609701,0.10655605169738974,0.9724218801201391,0.2939892762025509,0.531668510985794,2830]
["High","O60884","DnaJ homolog subfamily A member 2 [OS=Homo sapiens]",49,18,78,18,412,45.7,6.48,164.08,"stress response;other biological processes","other membranes;cytosol","other molecular function","DNAJA2","ENSG00000069345","","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","Protein processing in endoplasmic reticulum",3669.1,3668.6,3817.9,3983.3,3820.9,3987.9,0.9460231850136955,-0.08005255350620408,0.045699956943497405,1.3400842091032417,0.18431057015228705,0.734449757416981,1936]
["High","O60885-1","Bromodomain-containing protein 4 [OS=Homo sapiens]",12,13,29,10,1362,152.1,9.19,40.31,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD4","ENSG00000141867; ENSPTRG00000010619","VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome","Potential therapeutics for SARS","",812.9,946,909.9,2378.7,2148.6,2261.3,0.3931296585452082,-1.3469228870092702,5.9312548056392929E-5,4.226853418353095,0.012864232645119888,1.8906161144617466,36]
["High","O60888-1","Protein CutA [OS=Homo sapiens]",25,3,30,3,179,19.1,5.5,46.54,"other biological processes","other membranes","other molecular function","CUTA","ENSG00000112514; ENSG00000226492","","","",785.2,656.6,621.4,643.8,637.9,642.1,1.0724607547562122,0.10092485522642954,0.40371292734996284,0.39392734376068944,0.6309428616390131,0.20000996880415198,4996]
["High","O60890","Oligophrenin-1 [OS=Homo sapiens]",3,2,3,2,802,91.6,7.96,6.85,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","OPHN1","ENSG00000079482","","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle","",35.9,41.7,31.8,41.7,38.7,43.4,0.8836833602584812,-0.17839857642170853,0.20611423491518904,0.6858920134045203,0.43308394677551026,0.3634279140674891,3716]
["High","O60906","Sphingomyelin phosphodiesterase 2 [OS=Homo sapiens]",6,2,2,2,423,47.6,6.98,3.61,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SMPD2","ENSG00000135587","TNF-alpha signaling pathway; S1P receptor signal transduction","Glycosphingolipid metabolism; Ceramide signalling; TNFR1-mediated ceramide production","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",32.1,36.2,40.1,35.8,37.6,44.1,0.9225531914893618,-0.11629600009849042,0.4250842997174593,0.3715249351928161,0.6472422410674575,0.1889331470449417,5128]
["High","O60907","F-box-like/WD repeat-containing protein TBL1X [OS=Homo sapiens]",10,4,9,1,577,62.5,6.55,17.27,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1X","ENSG00000101849","Ectoderm differentiation; Ectoderm differentiation; Rett syndrome causing genes","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression","Wnt signaling pathway",96.1,72.6,86.1,84.2,81.2,87.1,1.009108910891089,0.013081889729780636,0.9182790641688079,0.037025317043786754,0.9608580719686481,0.017340757089961616,7462]
["High","O60911","Cathepsin L2 [OS=Homo sapiens]",8,3,8,2,334,37.3,8.76,14.61,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","CTSV","ENSG00000136943","Endochondral ossification; Endochondral ossification with skeletal dysplasias","MHC class II antigen presentation; Assembly of collagen fibrils and other multimeric structures; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; Trafficking and processing of endosomal TLR; Endosomal/Vacuolar pathway; Activation of Matrix Metalloproteinases","Lysosome; Apoptosis",467.5,488.4,520.6,395.5,399.5,444.1,1.1915906706480512,0.25288873341434714,0.02260330087628737,1.6458281339642167,0.12687747896624857,0.8966154592976278,1391]
["High","O60921","checkpoint protein HUS1 [OS=Homo sapiens]",20,4,12,4,280,31.7,6.84,21.23,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","","HUS1","ENSG00000136273","ATR signaling","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","Cellular senescence",311.8,313.2,304.5,306.5,327.1,332.1,0.9625142383763072,-0.055120212391990504,0.21900530980854083,0.659545355513333,0.44869941196145025,0.3480444996268648,3811]
["Medium","O60925","prefoldin subunit 1 [OS=Homo sapiens]",6,1,1,1,122,14.2,6.81,2.38,"other biological processes","other cell component","other molecular function","PFDN1","ENSG00000113068","Cellular proteostasis","Prefoldin mediated transfer of substrate  to CCT/TriC","",160.6,161.4,106.9,173.8,121.4,110.4,1.0574457593688362,0.08058366363221568,0.7848586092619452,0.10520857350699209,0.887241352413098,0.051958224854503625,6907]
["High","O60927","Protein phosphatase 1 regulatory subunit 11 [OS=Homo sapiens]",12,1,4,1,126,13.9,7.01,8.42,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R11","ENSG00000204619; ENSG00000206501; ENSG00000227720; ENSG00000233314; ENSG00000234058; ENSG00000236560; ENSG00000237403; ENSG00000237829","","","",119.6,99.9,97.7,117.9,90.8,106.3,1.006984126984127,0.010040942429337426,0.947636121050335,0.02335839362902851,0.9753681562300311,0.01083142733716482,7586]
["High","O60930","Ribonuclease H1 [OS=Homo sapiens]",12,4,7,4,286,32,9.16,13.39,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","RNASEH1","ENSG00000171865","","","DNA replication",366.8,362.7,324,321,318.2,345.7,1.0696517412935325,0.09714115841053184,0.23079445828381964,0.6367746234437405,0.4619438939451586,0.33541076909689643,3901]
["High","O60934","Nibrin [OS=Homo sapiens]",9,4,4,4,754,84.9,6.9,2.27,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NBN","ENSG00000104320","miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks","Homologous recombination; Cellular senescence",20.7,15.9,13.6,34.2,13.3,21.3,0.7296511627906977,-0.4547212007513258,0.3900379241231251,0.40889316364872597,0.6198689418997274,0.20770012312491237,4913]
["High","O60942-1","mRNA-capping enzyme [OS=Homo sapiens]",19,9,15,9,597,68.5,8.13,31.54,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RNGTT","ENSG00000111880; ENSGGOG00000007863; ENSNLEG00000013064; ENSPPAG00000024828; ENSPTRG00000018413","mRNA processing; Ciliary landscape; mRNA Processing","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA surveillance pathway",734.8,629.7,708.2,574.6,544.2,567.9,1.2288492322286118,0.2973079220093106,0.017327275916307717,1.7612697089252676,0.1099929840280737,0.95863501570603,1230]
["High","O75027-1","ATP-binding cassette sub-family B member 7, mitochondrial [OS=Homo sapiens]",22,13,31,13,752,82.6,9.33,70,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","ABCB7","ENSG00000131269","","Mitochondrial ABC transporters; Cytosolic iron-sulfur cluster assembly","ABC transporters",1951.4,1921.5,1987,1967.6,2065.8,2069.5,0.9601828638843828,-0.05861890603689208,0.10233327234771934,0.9899831380606211,0.2874166152845297,0.541488129320062,2780]
["High","O75037","Kinesin-like protein KIF21B [OS=Homo sapiens]",4,6,6,4,1637,182.5,7.08,15.92,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF21B","ENSG00000116852","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",187.3,194.1,179.2,174.4,188.3,189.4,1.0153957616373843,0.022042143240554448,0.6840128443301662,0.1649357430615491,0.8286690905399438,0.08161886009233553,6445]
["High","O75044","SLIT-ROBO Rho GTPase-activating protein 2 [OS=Homo sapiens]",28,29,63,26,1071,120.8,6.7,132.98,"","","","","","","","",2309.4,2404.3,2413,2382.8,2315.5,2307,1.0173297360569857,0.024787360092909563,0.37883886591725247,0.42154547215153276,0.6112779221082677,0.21376128960152127,4839]
["High","O75052","Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein [OS=Homo sapiens]",18,7,19,6,506,56.1,6.3,27.08,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","NOS1AP","ENSG00000198929","Sudden infant death syndrome (SIDS) susceptibility pathways","","Circadian entrainment",284.5,271.7,255.1,239.4,258.3,227.8,1.118263266712612,0.16125987410996911,0.08077169662300093,1.09274079459461,0.2540956515843639,0.5950027670986856,2482]
["High","O75054","Immunoglobulin superfamily member 3 [OS=Homo sapiens]",10,10,13,10,1194,135.1,6.07,25.92,"developmental processes","other membranes","","IGSF3","ENSG00000143061","","","",532.7,557.9,559.9,586.8,569.3,551.9,0.966334894613583,-0.0494048363979546,0.22429887726035225,0.6491729002951151,0.45583696867486473,0.3411904561621546,3842]
["High","O75063","Glycosaminoglycan xylosylkinase [OS=Homo sapiens]",20,7,19,7,409,46.4,6.87,40.25,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;nucleus","kinase activity;other molecular function","FAM20B","ENSG00000116199","","","",567.9,560.2,583.5,617.4,629.2,647.6,0.9036004645760743,-0.14624308241065204,5.463550035459416E-3,2.2625250752789112,0.062367541925244324,1.2050413723403919,684]
["High","O75064","DENN domain-containing protein 4B [OS=Homo sapiens]",1,1,1,1,1496,163.7,7.21,2.83,"other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","DENND4B","ENSG00000198837","","RAB GEFs exchange GTP for GDP on RABs","",20,14.3,17.8,14.1,19.9,24.7,0.8875638841567289,-0.17207713083154427,0.5621399786483579,0.2501555271622091,0.7491361927438774,0.12543922051109055,5859]
["High","O75083","WD repeat-containing protein 1 [OS=Homo sapiens]",52,22,173,22,606,66.2,6.65,467.8,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","WDR1","ENSG00000071127","Hypertrophy model","Platelet degranulation","",5968.8,5779.9,5815.5,5554.3,6032.3,5837.5,1.0080405874621934,0.011553728273925833,0.7716621931219709,0.11257277708673691,0.8808681877041445,0.05508907414821776,6840]
["Medium","O75093-1","Slit homolog 1 protein [OS=Homo sapiens]",1,1,2,1,1534,167.8,6.57,0,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","SLIT1","ENSG00000187122","Spinal cord injury","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO","Axon guidance",42.6,39.7,38.3,34.4,36.8,32.3,1.1652173913043482,0.2205991395133977,0.03481684430730715,1.4582105945636095,0.15722956642652067,0.8034657831788966,1729]
["High","O75096","Low-density lipoprotein receptor-related protein 4 [OS=Homo sapiens]",6,8,12,8,1905,211.9,5.27,18.09,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LRP4","ENSG00000134569","","ECM proteoglycans","",493.4,483.7,454.9,543.6,502.2,488.9,0.9330813839838406,-0.09992517549376109,0.16412064835041257,0.7848367760431073,0.3800278832503029,0.4201845373371766,3372]
["High","O75113","NEDD4-binding protein 1 [OS=Homo sapiens]",27,15,22,15,896,100.3,5.36,44.29,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","N4BP1","ENSG00000102921","","","",472.9,481.4,451.3,523.6,506.1,496.5,0.9209802122919669,-0.11875793524276836,0.028322745518706654,1.5478646497876927,0.14221478907399457,0.8470552384919137,1555]
["High","O75116","Rho-associated protein kinase 2 [OS=Homo sapiens]",32,43,81,39,1388,160.8,6.02,164.08,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","ROCK2","ENSG00000134318","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; G13 signaling pathway","RHOA GTPase cycle; RHOB GTPase cycle; G alpha (12/13) signalling events; RHOC GTPase cycle; Potential therapeutics for SARS; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; Wnt signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis",3334.4,3723,3831.7,3749.1,3528.4,3583.2,1.0026149327391418,3.7676265940303844E-3,0.9569692370268054,0.01910202293814397,0.9799364987154487,0.008802066298331992,7625]
["High","O75122","CLIP-associating protein 2 [OS=Homo sapiens]",28,29,69,23,1294,141,8.47,123.98,"","","","","","","","",1723.2,1757.4,1843.2,2058.8,1866.5,1928.3,0.9094915949159492,-0.13686778964293642,0.05779127019307607,1.238137760079704,0.21125198392674996,0.6751992037775875,2136]
["High","O75127","pentatricopeptide repeat-containing protein 1, mitochondrial [OS=Homo sapiens]",16,10,20,10,700,78.8,8.59,39.44,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity","PTCD1","ENSG00000106246","","","",793.7,786.7,787.1,786.2,737.6,751.2,{"$f":"AVERAGE(T578:V578)/AVERAGE(W578:Y578)","v":1.0406593406593405},{"$f":"LOG(Z578,2)","v":0.05749788038232618},{"$f":"TTEST(T578:V578,W578:Y578,2,2)","v":0.10315456507365478},{"$f":"-LOG10(AB578)","v":0.9865115476963776},{"$f":"AB578*7808/AF578","v":0.28889198138274624},{"$f":"-LOG10(AD578)","v":0.539264512463714},2788]
["High","O75128","Protein cordon-bleu [OS=Homo sapiens]",5,5,6,5,1261,135.5,7.75,9.69,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity","COBL","ENSG00000106078","","","",265.8,285.2,291.2,310.5,306.5,298.5,0.9199344620425997,-0.12039701051560549,0.04430784178266635,1.3535194037645104,0.1811286013817062,0.7420129663536026,1910]
["High","O75129","Astrotactin-2 [OS=Homo sapiens]",3,3,4,3,1339,148.1,5.97,2.75,"cell adhesion;transport;developmental processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","ASTN2","ENSG00000148219","","","",233.9,201.9,216.4,206.7,186.6,182.5,1.132684960055575,0.1797466521850311,0.09898719096587184,1.0044209998746378,0.2830069524209181,0.5482028953557357,2731]
["High","O75131","Copine-3 [OS=Homo sapiens]",18,7,16,7,537,60.1,5.85,30.52,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CPNE3","ENSG00000085719","","Neutrophil degranulation; Glycerophospholipid biosynthesis","",546.6,559.6,556.4,548.5,553.1,520.2,1.0251572327044023,0.03584519894672187,0.2841237046384744,0.5464925312745225,0.5203935927321623,0.28366805926301925,4263]
["High","O75132","Zinc finger BED domain-containing protein 4 [OS=Homo sapiens]",1,1,1,1,1171,130.2,6.83,2.39,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED4","ENSG00000100426","","","",25.6,26.9,25,17.4,14.9,18.5,1.5255905511811023,0.609367813389434,0.001784324353381448,2.7485261970003623,0.03735121863593122,1.4276952241504144,373]
["High","O75143-1","Autophagy-related protein 13 [OS=Homo sapiens]",22,7,15,7,517,56.5,5.12,28.19,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","ATG13","ENSG00000175224","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease","Macroautophagy","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",571.1,563.3,576.7,603.8,576.7,597.3,0.9624817189785128,-0.05516895594779487,0.06984571231908959,1.1558602491534367,0.23285880520386487,0.6329073352311456,2342]
["High","O75145-1","Liprin-alpha-3 [OS=Homo sapiens]",6,9,9,3,1194,133.4,5.68,19.15,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;other cell component","","PPFIA3","ENSG00000177380","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",314.2,345,352.7,382.2,373.2,331.5,0.9309964118134143,-0.10315248743516094,0.2701558999867415,0.5683855433803645,0.5058458674092272,0.29598179369548666,4170]
["High","O75146","Huntingtin-interacting protein 1-related protein [OS=Homo sapiens]",20,19,30,18,1068,119.3,6.67,74.35,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","cytoskeletal activity;other molecular function","HIP1R","ENSG00000130787","","Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",1092.5,1133.3,1125.2,1139.8,1135.1,1112.6,0.9892250922509226,-0.015629259924125102,0.463711806696057,0.3337518462701022,0.6792986466571882,0.16793925063803905,5330]
["High","O75147","Obscurin-like protein 1 [OS=Homo sapiens]",9,12,17,12,1896,206.8,5.63,32.06,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","OBSL1","ENSG00000124006","","Neddylation","",640.5,648.5,654.6,785.7,812.1,839.9,0.7973089387537432,-0.3267892514159825,5.2359370762345672E-4,3.281005581297812,0.02246274543474698,1.6485371646242517,182]
["High","O75150","E3 ubiquitin-protein ligase BRE1B [OS=Homo sapiens]",39,39,91,37,1001,113.6,6.23,233.37,"protein metabolism;other metabolic processes","nucleus","other molecular function","RNF40","","","","",3442.9,3706.9,3641,3661.4,3758,3668.7,0.9731874712529649,-0.0392103476459203,0.30939488232215184,0.5094868742101202,0.545933387835336,0.262860344585329,4425]
["High","O75152","Zinc finger CCCH domain-containing protein 11A [OS=Homo sapiens]",36,27,85,27,810,89.1,8.37,174.52,"other metabolic processes;transport","nucleus","nucleic acid binding activity;other molecular function","ZC3H11A","ENSG00000058673","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",4385.8,4588.6,4450.4,4840.2,4608.1,4605.4,0.9552502188035891,-0.06604941184991299,0.09955643437233754,1.0019306661027017,0.2834925746094863,0.5474583118975601,2742]
["High","O75153","Clustered mitochondria protein homolog [OS=Homo sapiens]",31,32,66,32,1309,146.6,6.13,126.38,"cell organization and biogenesis","other cell component","nucleic acid binding activity","CLUH","ENSG00000132361","Translation factors","","",2215.8,2273.1,2217.2,2184.4,2179.1,2222,1.0183129602915495,0.026181016101539833,0.15823760216961297,0.8006903067150181,0.37372026549919485,0.42745335129181133,3306]
["High","O75154","Rab11 family-interacting protein 3 [OS=Homo sapiens]",3,2,2,1,756,82.4,4.51,2.62,"cell cycle OR cell proliferation;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RAB11FIP3","ENSG00000090565; ENSG00000275338","","VxPx cargo-targeting to cilium","Endocytosis",33.9,30.8,31.1,29.9,32.4,27.8,1.063263041065483,0.08849854992264204,0.31519006789935644,0.501427476222026,0.5521660422163283,0.2579303056495669,4457]
["High","O75157","TSC22 domain family protein 2 [OS=Homo sapiens]",8,6,17,5,780,79.2,5.02,28.74,"stress response;other biological processes","","","TSC22D2","ENSG00000196428","","","",816.6,835.9,843.6,765.1,632.9,689.1,1.1959656940252026,0.2581760067855546,0.025273737785800998,1.5973305246133105,0.134151831836529,0.8724033926822052,1471]
["High","O75164-1","Lysine-specific demethylase 4A [OS=Homo sapiens]",16,13,28,13,1064,120.6,5.85,65.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","KDM4A","ENSG00000066135","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","",1260.3,1270.9,1289.6,1092.7,1154.5,1174.7,1.116572664309302,0.15907714191494363,7.0195766653338935E-3,2.1536890783905966,0.07053906641303352,1.1515702925328755,777]
["High","O75165","DnaJ homolog subfamily C member 13 [OS=Homo sapiens]",14,25,39,25,2243,254.3,6.74,89.93,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","DNAJC13","ENSG00000138246","","Neutrophil degranulation","",1508.8,1492.5,1534.1,1419.7,1567.1,1480.7,1.0151986569669837,0.021762065713687714,0.6373545758581797,0.1956188918461378,0.8002033330600847,0.09679964400102567,6219]
["High","O75167","Phosphatase and actin regulator 2 [OS=Homo sapiens]",4,2,3,2,634,69.7,8.16,6.72,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","enzyme regulator activity;cytoskeletal activity","PHACTR2","ENSG00000112419","","Platelet degranulation","",139.9,157.4,146.4,149.5,139.1,146.6,1.0195312499999998,0.02790599656988417,0.6600145131682809,0.1804465145799494,0.8134796083374802,0.08965332914077412,6335]
["High","O75170","Serine/threonine-protein phosphatase 6 regulatory subunit 2 [OS=Homo sapiens]",7,4,5,4,966,104.9,4.87,2.06,"other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP6R2","ENSG00000100239","","","",102.9,86,87.9,76,57.9,82.2,1.2808884775566864,0.35714487077721707,0.08878184642105713,1.0516758270721103,0.2679585067087801,0.5719324511300182,2587]
["High","O75175","CCR4-NOT transcription complex subunit 3 [OS=Homo sapiens]",16,9,19,9,753,81.8,6.2,32.73,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","","CNOT3","ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615","","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",809.5,801.5,819.4,909,850.1,873.3,0.9232639416502052,-0.11518495202701151,0.01972999795180967,1.7048729598323402,0.11768664935655454,0.9292728017244606,1309]
["High","O75177","Calcium-responsive transactivator [OS=Homo sapiens]",9,2,2,2,396,43,6.44,2.63,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SS18L1","ENSG00000184402","","","",92.4,90,64.9,96.3,79.9,100.5,0.8937477412359957,-0.1620604042200168,0.4158649444256305,0.3810476871949778,0.6405747654518293,0.19343017375974417,5069]
["High","O75179-1","Ankyrin repeat domain-containing protein 17 [OS=Homo sapiens]",18,36,76,24,2603,274.1,6.52,163.5,"stress response;developmental processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","ANKRD17","ENSG00000132466","","","",2557.8,2567.3,2547,2499.4,2503.4,2442,1.0305313776058458,0.04338843270557988,0.021516857770864588,1.6672211508687311,0.12245162206626145,0.9120354575808285,1372]
["High","O75182-2","Isoform 2 of Paired amphipathic helix protein Sin3b [OS=Homo sapiens]",13,10,15,9,1130,129.3,6.98,26.54,"","","","SIN3B","","","","",304,294.3,293.9,314.8,309,297.4,0.968519322622666,-0.04614726301927081,0.18753950732876137,0.7269072292295715,0.41017044067870273,0.38703564068312934,3570]
["High","O75190","DnaJ homolog subfamily B member 6 [OS=Homo sapiens]",36,12,36,11,326,36.1,9.16,88.88,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNAJB6","ENSG00000105993","","Regulation of HSF1-mediated heat shock response","",1560.2,1646,1543.9,1579.2,1543.3,1514.1,1.0244791442004917,0.03489061503262886,0.36249669948440166,0.4406959433060558,0.5978821777723295,0.2233843922404844,4734]
["High","O75191","xylulose kinase [OS=Homo sapiens]",7,3,3,3,536,58.3,5.86,8.4,"other metabolic processes","cytosol","kinase activity;other molecular function","XYLB","ENSG00000093217","","Formation of xylulose-5-phosphate","Pentose and glucuronate interconversions; Metabolic pathways",147.8,149.9,163.4,140.8,159.3,172.7,0.9752538071065991,-0.03615036976560473,0.7281791593034301,0.13776175485694894,0.8560106708583533,0.06752082146067999,6642]
["High","O75208-1","Ubiquinone biosynthesis protein COQ9, mitochondrial [OS=Homo sapiens]",9,2,4,2,318,35.5,5.94,15.33,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ9","ENSG00000088682","","Ubiquinol biosynthesis","",118,115.5,112.4,112.3,106.3,101.8,1.0795880149812733,0.11048086596421781,0.06918462993988687,1.1599903777067186,0.23204192034821167,0.6344335490259342,2328]
["High","O75223-1","gamma-glutamylcyclotransferase [OS=Homo sapiens]",59,10,47,10,188,21,5.14,103.14,"cell organization and biogenesis;signal transduction","cytosol","other molecular function","C7orf24; GGCT","ENSG00000006625; ENSGGOG00000024930; ENSPPAG00000031715; ENSPTRG00000019041","Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases","Glutathione synthesis and recycling","Glutathione metabolism; Metabolic pathways",2189.6,1962.4,1997.7,2039.2,2102.4,2148.6,0.977663667291978,-0.032589855664092,0.5776976144060622,0.238299425867662,0.7598825763616127,0.11925351347999728,5936]
["High","O75251","NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [OS=Homo sapiens]",14,3,12,3,213,23.5,9.99,24.45,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cell component","transporter activity;other molecular function","NDUFS7","ENSG00000115286","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",414.8,431.7,420.9,423.7,442.5,449.1,0.9635824526723941,-0.05351997328380988,0.15323897153794128,0.8146307714429132,0.3667964101067583,0.4355749234885348,3262]
["High","O75290-1","Zinc finger protein 780A [OS=Homo sapiens]",3,1,1,1,641,74.5,8.65,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF780A","ENSG00000197782; ENSG00000280568","","","Herpes simplex virus 1 infection",241.5,230.3,217.2,260.7,255.7,282.2,0.8627598297019785,-0.2129690890413942,0.027252899355177548,1.564587287626883,0.13953484469850905,0.8553173266510522,1525]
["High","O75306-1","NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [OS=Homo sapiens]",29,10,26,10,463,52.5,7.55,62.3,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS2","ENSG00000158864","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",947,978.4,935.6,962.7,1052.5,1022.3,0.9418930041152263,-0.08636491105732277,0.11526358591834843,0.9383078733862256,0.307474574257077,0.5121907911613821,2927]
["High","O75312","Zinc finger protein ZPR1 [OS=Homo sapiens]",28,12,22,12,459,50.9,4.73,52.98,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ZPR1","ENSG00000109917","","","",1509,1531.8,1566.3,1512.1,1445.2,1462.7,1.0423303167420814,0.05981254326753717,0.07483875552026947,1.125873442914057,0.2438818877722304,0.6128204519726954,2396]
["High","O75323-1","Protein NipSnap homolog 2 [OS=Homo sapiens]",23,6,14,5,286,33.7,9.36,26.19,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;mitochondrion","","NIPSNAP2","ENSG00000146729","","RHOJ GTPase cycle; RHOH GTPase cycle","",478.4,465.8,428.1,449.4,451.3,436.4,1.026325630094982,0.037488538341851674,0.499460732393654,0.3014986503311265,0.7063556237148434,0.15097659281262937,5521]
["High","O75326-1","Semaphorin-7A [OS=Homo sapiens]",11,5,9,5,666,74.8,7.64,24.53,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding","SEMA7A","ENSG00000138623; ENSG00000288455","","Other semaphorin interactions","Axon guidance",251.3,209.7,234.9,191.6,190.9,203.9,1.1867326057298773,0.24699490393953422,0.04646339828189718,1.3328890295529299,0.18604421219746317,0.7303838362568125,1950]
["High","O75330-1","Hyaluronan mediated motility receptor [OS=Homo sapiens]",38,27,58,26,724,84,5.83,119.76,"","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","HMMR","ENSG00000072571","","AURKA Activation by TPX2; Hyaluronan uptake and degradation","ECM-receptor interaction",2245.6,2589.6,2567.9,2147.1,1961.1,2005,1.2110024209906434,0.27620174921696833,0.02602821673322177,1.5845555856153615,0.13584780498194893,0.8669473744851686,1496]
["High","O75340","programmed cell death protein 6 [OS=Homo sapiens]",41,6,10,1,191,21.9,5.4,17.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PDCD6","ENSG00000249915","Epithelial to mesenchymal transition in colorectal cancer","","",210.3,189.6,206.9,190.9,198.9,180.9,1.0632556509549673,0.08848852257058279,0.21877468708428507,0.6600029286620466,0.4486978609808505,0.34804600081777837,3807]
["High","O75340-2","Isoform 2 of Programmed cell death protein 6 [OS=Homo sapiens]",40,6,9,1,189,21.7,5.4,15.25,"","","","PDCD6","","","","",553.7,499.2,519.8,531,558,546.5,0.9616019565881995,-0.056488263358625154,0.30266008311867126,0.5190448529926167,0.5397829897191835,0.2677808055658941,4378]
["High","O75347","Tubulin-specific chaperone A [OS=Homo sapiens]",44,5,7,5,108,12.8,5.29,8.45,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TBCA","ENSG00000171530","VEGFA-VEGFR2 signaling pathway","Post-chaperonin tubulin folding pathway","",364.2,293.5,287.1,353.2,305.9,257.8,1.0304286181699207,0.043244567197233894,0.8139048668281279,0.0894263546023132,0.9061698560094144,0.042790388842460315,7013]
["High","O75351","Vacuolar protein sorting-associated protein 4B [OS=Homo sapiens]",38,14,32,11,444,49.3,7.23,58.84,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS4B","ENSG00000119541","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)","Endocytosis; Necroptosis",1163.3,1190.1,1207.8,1263.6,1177.3,1179.1,0.9837569060773481,-0.023626236360178476,0.5648124644364305,0.24809572772071622,0.751287175863654,0.12419402430969534,5870]
["High","O75352","Mannose-P-dolichol utilization defect 1 protein [OS=Homo sapiens]",10,2,10,2,247,26.6,8.94,17.33,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","","MPDU1","ENSG00000129255","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective MPDU1 causes CDG-1f","",262.4,301.5,306,256,335.2,293.3,0.9834934991520633,-0.024012578501580544,0.8644293451351253,0.06327049836684698,0.9335358681625252,0.02986899100274245,7230]
["High","O75362","zinc finger protein 217 [OS=Homo sapiens]",13,11,16,10,1048,115.2,8.48,31,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","ZNF217","ENSG00000171940","","Estrogen-dependent gene expression","",748.8,805.1,794.9,951.2,909.5,899.3,0.8510144927536233,-0.23274439370968084,0.004301736693457429,2.3663561760215783,0.056545387377972406,1.2476028163441362,594]
["High","O75367-1","Core histone macro-H2A.1 [OS=Homo sapiens]",42,14,65,12,372,39.6,9.79,178.74,"cell organization and biogenesis;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","H2afy; H2AFY; LOC100466888; LOC101338325; LOC101381952; LOC101564704; LOC102987354; LOC103079324; LOC103663804; LOC106989149; LOC109250833; LOC110591142; LOC111141291; LOC111182462; LOC112404331; LOC112815157; LOC112861289; LOC112917035; LOC113261754; LOC113928700; LOC115516119; LOC116529369; MACROH2A1","ENSAMEG00000017887; ENSCAFG00000001076; ENSCANG00000022762; ENSCJAG00000005818; ENSFCAG00000013924; ENSG00000113648; ENSGGOG00000001707; ENSLCNG00005003680; ENSMLEG00000037795; ENSMNEG00000031666; ENSMPUG00000010011; ENSPCOG00000013464; ENSPCTG00005011747; ENSPPAG00000029258; ENSPTRG00000017256; ENSRBIG00000034425; ENSRROG00000045755; ENSSBOG00000034640; ENSSSUG00005001976; ENSVVUG00000017487","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma","","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus",4196.1,4054.3,4000.4,4091.9,4382.4,4364.6,0.9541938951156252,-0.06764563882566377,0.15114926081609883,0.8205939723649227,0.36413866968593017,0.43873319873849725,3241]
["High","O75368","SH3 domain-binding glutamic acid-rich-like protein [OS=Homo sapiens]",89,8,27,8,114,12.8,5.25,54.5,"","nucleus;other cell component","other molecular function","SH3BGRL","ENSG00000131171","","","",977,915.1,907.4,1126.6,918.7,945.1,0.9361623863028357,-0.09516929414480328,0.40835113502726555,0.3889662329360319,0.6356470618606238,0.19678395610005656,5016]
["High","O75369-1","Filamin-B [OS=Homo sapiens]",69,132,616,1,2602,278,5.73,1319.52,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLNB","ENSG00000136068","Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host","ISG15 antiviral mechanism","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer",13.2,18.8,13.3,18.2,9.1,15.3,1.063380281690141,0.08865761982039704,0.796159370347499,0.09899998912834827,0.8947052912598261,0.048319994244773894,6948]
["High","O75369-8","Isoform 8 of Filamin-B [OS=Homo sapiens]",68,132,613,1,2633,281.5,5.71,1316.89,"","","","FLNB","","","","",20886.3,21148.3,20928.5,20466.8,19360.4,20101.6,1.0506317496762825,0.07125708793803592,0.03935391144359575,1.4050120959873043,0.16818573648144258,0.7742108386812068,1827]
["High","O75376-1","Nuclear receptor corepressor 1 [OS=Homo sapiens]",5,12,14,11,2440,270,7.11,29.93,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NCOR1","ENSG00000141027","Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome causing genes; 22q11.2 copy number variation syndrome; Notch signaling pathway","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis","Endocrine resistance; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer",774.2,827.1,851.4,903.2,812,783.3,0.9816690014008406,-0.02669143545447722,0.7389356148164827,0.13139340104777952,0.8625518433976823,0.06421479234177747,6689]
["High","O75379-1","Vesicle-associated membrane protein 4 [OS=Homo sapiens]",33,3,6,3,141,16.4,7.34,9.78,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP4","ENSCATG00000035773; ENSG00000117533; ENSGGOG00000023200; ENSMFAG00000031870; ENSMLEG00000033096; ENSMMUG00000023203; ENSMNEG00000025169; ENSNLEG00000015204; ENSPANG00000022546; ENSPPAG00000028975; ENSPTRG00000001680; ENSRBIG00000031656; ENSRROG00000036404","","Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network","SNARE interactions in vesicular transport",154.6,137.3,105.1,156.9,107.5,137.8,0.9870711089010443,-0.018774074275031655,0.9364494639224885,0.028515654628088118,0.9706355255949543,0.01294381740203758,7533]
["High","O75380","NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [OS=Homo sapiens]",39,3,4,3,124,13.7,8.28,14.64,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS6","ENSG00000145494","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",170.3,177.3,166.4,206,177.3,186.3,0.9023876404494382,-0.14818078688515732,0.11008928781759303,0.9582549377770507,0.2991914929619793,0.5240507591103628,2873]
["High","O75381-1","Peroxisomal membrane protein PEX14 [OS=Homo sapiens]",24,8,20,8,377,41.2,4.94,58.29,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PEX14","ENSG00000142655; ENSMFAG00000032533; ENSMMUG00000019979; ENSPANG00000017539; ENSPPAG00000038193; ENSPTRG00000000132","","Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Class I peroxisomal membrane protein import","Peroxisome",1176.3,1232,1229.1,1270.8,1236.6,1210,0.9784795825039007,-0.031386347793783576,0.35041764511094137,0.4554140332648774,0.5866339993623993,0.23163277035719962,4664]
["High","O75382-1","Tripartite motif-containing protein 3 [OS=Homo sapiens]",4,3,6,1,744,80.8,7.83,14.47,"protein metabolism;other metabolic processes;transport;developmental processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TRIM3","ENSG00000110171; ENSPTRG00000003290","","Interferon gamma signaling","",64.2,59.4,61.6,62.9,52.6,60.4,1.05287094940307,0.07432861578827538,0.4132049276743883,0.3838345079437172,0.6392518476880571,0.19432800801876768,5047]
["High","O75385","Serine/threonine-protein kinase ULK1 [OS=Homo sapiens]",3,2,2,2,1050,112.6,8.79,3.78,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","ULK1","ENSG00000177169","Target of rapamycin (TOR) signaling; Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; p53 transcriptional gene network; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease","RAB GEFs exchange GTP for GDP on RABs; Macroautophagy; TBC/RABGAPs; Receptor Mediated Mitophagy","Mitophagy; Autophagy; mTOR signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",25,20.5,17.6,15.5,22.2,19.5,1.1031468531468533,0.14162485820415985,0.5351552102179453,0.2715202419689037,0.7292306948310151,0.1371350592776583,5730]
["Medium","O75386","Tubby-related protein 3 [OS=Homo sapiens]",2,1,2,1,442,49.6,7.74,3.95,"developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TULP3","ENSG00000078246","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Genes related to primary cilium development (based on CRISPR)","Hedgehog 'off' state","",122.5,136.3,140.2,152.7,141.8,143.6,0.9107509700981511,-0.13487146821324253,0.10902812008674798,0.962461476155854,0.29755035359571064,0.5264395293024813,2861]
["High","O75390","citrate synthase, mitochondrial [OS=Homo sapiens]",39,16,87,16,466,51.7,8.32,160.5,"other metabolic processes","mitochondrion","other molecular function","CS","ENSG00000062485","TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)","Mitochondrial protein import; Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids",5112.7,4886.9,5015.9,4728.7,4911.8,5064.5,1.0211152669160148,0.03014573166311,0.42650633014719375,0.3700745187107734,0.6477653035964382,0.18858231791917188,5141]
["High","O75391","Sperm-associated antigen 7 [OS=Homo sapiens]",20,3,4,3,227,26,7.91,9.82,"","nucleus","nucleic acid binding activity","SPAG7","ENSG00000091640","","","",96.5,73.2,73.5,102.5,73.7,72.7,0.9770992366412214,-0.03342300153745017,0.8861025409779066,0.052516018063213134,0.9468576214527843,0.023715320749794863,7307]
["High","O75396","Vesicle-trafficking protein SEC22b [OS=Homo sapiens]",38,8,52,8,215,24.6,6.92,131.89,"","","","","","","","",1438.8,1350.1,1365.4,1394.1,1381.6,1388.4,0.9976465502749691,-3.3993118729169253E-3,0.9115305302688648,0.04022878076078789,0.9585495461736425,0.01838543409140248,7425]
["High","O75400","pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",34,34,103,1,957,108.7,7.56,201.48,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","PRPF40A","ENSG00000196504","mRNA processing","mRNA Splicing - Major Pathway","Spliceosome",184.1,177.9,192.1,187.9,188.6,185.7,0.9855923159018144,-0.02093708667674853,0.5554918539679619,0.25532230540484785,0.7442142065514492,0.128302043844165,5828]
["High","O75400-3","Isoform 3 of Pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",34,34,102,1,939,106.8,7.43,195.17,"","","","PRPF40A","","","","",5697,5367.3,5362.6,5290.3,4792.3,5087.8,1.082825765965301,0.11480112217059249,0.08293572524585441,1.0812583532254483,0.2580957125227705,0.5882192098814234,2509]
["High","O75410-1","Transforming acidic coiled-coil-containing protein 1 [OS=Homo sapiens]",27,16,31,13,805,87.7,4.88,72.42,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TACC1","ENSG00000147526","","","",1544.6,1539,1523.2,1393.3,1338.3,1362.2,1.1253114465777516,0.17032434388602286,5.7009176758780679E-4,3.2440552303815946,0.022595312290992868,1.645981651884552,197]
["High","O75414","Nucleoside diphosphate kinase 6 [OS=Homo sapiens]",10,2,4,2,186,21.1,8.32,11.3,"other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","NME6","ENSG00000172113","Pyrimidine metabolism","","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",103.7,106.7,122.3,126.7,112.8,118.1,0.9303691275167785,-0.10412487030045171,0.304091989433486,0.5169950201408259,0.5403619147693806,0.26731526806668204,4394]
["High","O75420","GRB10-interacting GYF protein 1 [OS=Homo sapiens]",20,17,26,17,1035,114.5,5.39,41.2,"signal transduction","cytosol;other cell component","","GIGYF1","ENSG00000146830","","","",736.3,744.7,786.9,971.6,836.5,850.3,0.8531071321095397,-0.22920117015729327,0.0464319153049673,1.333183401424881,0.18610903218746647,0.7302325493088422,1948]
["High","O75427","Leucine-rich repeat and calponin homology domain-containing protein 4 [OS=Homo sapiens]",33,15,22,15,683,73.4,8.22,37.93,"developmental processes","nucleus","","LRCH4","ENSG00000077454","","","",389.1,344.2,363.9,308.8,274,280.8,1.2704955998147291,0.3453913788257722,0.009771441513821604,2.0100413630654406,0.08159937469510063,1.0883131692793229,935]
["High","O75431","Metaxin-2 [OS=Homo sapiens]",32,7,28,7,263,29.7,6.29,81.16,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus;other cell component","","MTX2","ENSG00000128654","","Mitochondrial protein import; Cristae formation","",1015.7,989,984.4,948.4,965.7,1009.4,1.022438857533778,0.03201457170466955,0.34845366188089455,0.45785496714262114,0.5851024068744138,0.2327681153739397,4650]
["High","O75436-1","Vacuolar protein sorting-associated protein 26A [OS=Homo sapiens]",30,9,24,8,327,38.1,6.57,44.85,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26A","ENSANAG00000022406; ENSCATG00000037809; ENSCCAG00000021117; ENSCJAG00000012907; ENSCSAG00000007798; ENSG00000122958; ENSMFAG00000042937; ENSMMUG00000004101; ENSMNEG00000039163; ENSNLEG00000011548; ENSPANG00000022152; ENSPPAG00000041182; ENSPPYG00000002386; ENSPTRG00000002567; ENSRBIG00000023684; ENSRROG00000006745; ENSSBOG00000030031","","WNT ligand biogenesis and trafficking","Endocytosis",562.8,622.5,630.4,550.3,723.1,606.6,0.9657978723404255,-0.05020680964071817,0.7174672555808506,0.14419791486582212,0.8499445200387318,0.07060942184735945,6591]
["Medium","O75438","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [OS=Homo sapiens]",19,1,1,1,58,7,8.92,2.39,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB1","ENSG00000183648","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",51.2,57.9,36.3,38.3,44.1,33.3,1.256698357821953,0.32963840481210416,0.235955944031139,0.6271690777513835,0.46807520604551156,0.32968436285205205,3936]
["High","O75439","mitochondrial-processing peptidase subunit beta [OS=Homo sapiens]",36,14,45,13,489,54.3,6.83,111.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;mitochondrion","other molecular function","PMPCB","ENSG00000105819","","Mitochondrial protein import; Processing of SMDT1","",2047.1,1981.1,1940,1894.6,1923.5,1983.9,1.0286452947259566,0.0407455869361809,0.24612596454551774,0.6088425688894776,0.47888151785980626,0.31977192396468096,4013]
["High","O75448","Mediator of RNA polymerase II transcription subunit 24 [OS=Homo sapiens]",20,15,19,15,989,110.2,6.95,36.25,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED24","ENSG00000008838","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",763.9,803.2,794.6,838.1,795.1,801.8,0.9698973305954824,-0.04409605736099655,0.24416630630005753,0.6123142666710388,0.47601760788785247,0.3223769824326599,4005]
["High","O75449-1","Katanin p60 ATPase-containing subunit A1 [OS=Homo sapiens]",31,13,18,12,491,55.9,6.9,33.94,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNA1","ENSG00000186625","","","",489.6,452.2,443.1,458.5,430.5,420.5,{"$f":"AVERAGE(T642:V642)/AVERAGE(W642:Y642)","v":1.0575792287132495},{"$f":"LOG(Z642,2)","v":0.08076574711835544},{"$f":"TTEST(T642:V642,W642:Y642,2,2)","v":0.23974264197900963},{"$f":"-LOG10(AB642)","v":0.6202547130288365},{"$f":"AB642*7808/AF642","v":0.4718705693400825},{"$f":"-LOG10(AD642)","v":0.3261771088443516},3967]
["High","O75461-1","transcription factor E2F6 [OS=Homo sapiens]",15,3,5,3,281,31.8,5.5,8.22,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F6","ENSG00000169016; ENSPPAG00000036538; ENSPTRG00000011661","G1 to S cell cycle control; Cell cycle","Transcriptional Regulation by E2F6; G1/S-Specific Transcription","",73.2,91.3,82.2,98,101.7,96.7,0.8323211875843455,-0.26478773200571076,0.03810733133510244,1.4189914639022005,0.16438786909639772,0.7841302341127495,1810]
["High","O75475-1","PC4 and SFRS1-interacting protein [OS=Homo sapiens]",65,40,255,39,530,60.1,9.13,511.39,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSIP1","ENSG00000164985; ENSGGOG00000016152; ENSPTRG00000020786","MECP2 and associated Rett syndrome","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection","",15520.3,14882,14925.2,15015.9,13547.4,14612.1,1.0498455138805893,0.07017704907632437,0.21242925505601992,0.6727856738688622,0.44101239656405306,0.35554920263262596,3761]
["High","O75477","erlin-1 [OS=Homo sapiens]",27,10,41,7,346,38.9,7.87,78.23,"","","","","","","","",501.4,475,453,478.6,504.7,460.3,0.9901634801884179,-0.014261354961826938,0.8157142830128685,0.08846193320667044,0.9065040025283914,0.042630274004041784,7026]
["High","O75478","Transcriptional adapter 2-alpha [OS=Homo sapiens]",5,2,3,2,443,51.5,6.89,4.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TADA2A","ENSG00000277104","","HATs acetylate histones","",44.6,51.8,47.8,50,63.1,47,0.9006870705808868,-0.15090214327543466,0.3790519774736624,0.42130123335058905,0.6113691055803255,0.2136965113328434,4841]
["High","O75487","Glypican-4 [OS=Homo sapiens]",8,3,5,2,556,62.4,6.68,10.26,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC4","ENSG00000076716","Wnt signaling","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Wnt signaling pathway",120.3,131,141.8,153,165.5,155.7,0.8289751159848165,-0.27059929905791386,0.020557950937398137,1.6870201747413875,0.11996747452855354,0.9209364835145565,1338]
["High","O75489","NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [OS=Homo sapiens]",54,15,51,15,264,30.2,7.5,109.18,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS3","ENSG00000213619; ENSG00000285387","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","RHOG GTPase cycle; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",2464,2256.6,2165.6,2482.4,2378.3,2422.7,0.9454650300683747,-0.08090399671226169,0.2289070764082966,0.6403407813858703,0.460408668880984,0.3368565077795789,3882]
["High","O75494-1","Serine/arginine-rich splicing factor 10 [OS=Homo sapiens]",31,12,42,9,262,31.3,11.27,92.81,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Srsf10; SRSF10","ENSCATG00000031598; ENSCCAG00000022497; ENSCPOG00000034102; ENSG00000188529; ENSGGOG00000000392; ENSMLEG00000016013; ENSMNEG00000041500; ENSMUSG00000028676; ENSNLEG00000027520; ENSPANG00000021680; ENSPCOG00000022379; ENSPCTG00005007467; ENSPPAG00000032557; ENSPPYG00000001726; ENSPTRG00000044753; ENSRBIG00000028456; ENSRFEG00010001865; ENSRROG00000043248; ENSSBOG00000019550; ENSSSCG00070027414; ENSSTOG00000000956; ENSTSYG00000009439","mRNA processing; mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","Spliceosome",2382.9,2587.3,2498.7,2894.9,2512.4,2743.1,0.9163844719277584,-0.12597508240651478,0.14566008206255432,0.836659449707133,0.3578709631039724,0.44627353791985835,3178]
["High","O75496","Geminin [OS=Homo sapiens]",13,2,2,2,209,23.6,4.96,2.77,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","GMNN","ENSG00000112312","DNA replication","CDT1 association with the CDC6:ORC:origin complex; Activation of the pre-replicative complex","",173.3,178.2,171.8,261.4,167.4,150.5,0.9033316071120316,-0.14667240605709156,0.6176888031077148,0.20923027108032038,0.7874145591289856,0.10379655945825508,6125]
["High","O75503","Ceroid-lipofuscinosis neuronal protein 5 [OS=Homo sapiens]",10,2,2,2,358,41.5,7.4,5.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLN5","ENSG00000102805","","","Lysosome",14.2,25.9,19.4,16.7,20.6,21.1,1.0188356164383563,0.02692129931528882,0.9250013696247045,0.033857624212306786,0.9646601701655794,0.01562565268171033,7487]
["High","O75506","Heat shock factor-binding protein 1 [OS=Homo sapiens]",42,3,4,3,76,8.5,4.36,11.36,"stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","HSBP1","ENSG00000230989","","HSF1 activation; Attenuation phase","",344.5,349.5,245.4,290,241.7,230.8,1.232,0.3010022560328143,0.2000970363864316,0.6987593436004234,0.4246691112001244,0.371949326772915,3679]
["High","O75509","Tumor necrosis factor receptor superfamily member 21 [OS=Homo sapiens]",4,2,2,2,655,71.8,7.83,4.16,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","","TNFRSF21","ENSG00000146072","Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer","PPARA activates gene expression","Cytokine-cytokine receptor interaction",35.3,37.7,29.7,39.3,31.1,45.6,0.885344827586207,-0.17568862369673918,0.4097965226167594,0.38743173118314095,0.6363745522258666,0.19628719553842575,5028]
["High","O75521","Enoyl-CoA delta isomerase 2, mitochondrial [OS=Homo sapiens]",28,6,15,6,394,43.6,9,42.82,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ECI2","ENSG00000198721","","","Fatty acid degradation; Peroxisome",340.9,364.3,352.3,396.2,378.3,403.7,0.8975555932778815,-0.15592679476795027,0.016459359605261938,1.783587066165754,0.10665118655426159,0.9720343084180059,1205]
["High","O75525-1","KH domain-containing, RNA-binding, signal transduction-associated protein 3 [OS=Homo sapiens]",10,4,18,2,346,38.8,7.61,29.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHDRBS3","ENSCCAG00000031191; ENSG00000131773; ENSGGOG00000000940; ENSRBIG00000036854; ENSRROG00000044792","","PTK6 Regulates Proteins Involved in RNA Processing","",99,98.2,91.7,95.1,93.8,80.3,1.0731797919762258,0.10189179395429836,0.28043279348389555,0.5521712018453838,0.5162978664282614,0.2870996696464581,4241]
["High","O75529-1","TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L [OS=Homo sapiens]",12,4,4,4,589,66.1,5.88,7.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","TAF5L","ENSG00000135801; ENSGGOG00000028544; ENSPPAG00000034307; ENSPTRG00000002091","","HATs acetylate histones","Basal transcription factors",116.9,121.6,131.6,112.8,121.6,117.1,1.0529160739687056,0.0743904463403229,0.28473708414695603,0.5455559666726529,0.5210281586640338,0.28313880487332965,4267]
["High","O75530","Polycomb protein EED [OS=Homo sapiens]",20,7,11,7,441,50.2,7.03,18.24,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","EED","ENSG00000074266","Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma","Transcriptional Regulation by E2F6; HCMV Early Events; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis","",525.3,528,509.5,551.3,597.6,603.7,0.8917037544220014,-0.16536360336666212,0.022539141099369643,1.6470626376648656,0.1266995059063198,0.8972250787438457,1389]
["High","O75531","Barrier-to-autointegration factor [OS=Homo sapiens]",25,3,5,3,89,10.1,6.09,2.34,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BANF1","ENSG00000175334","Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation","",178.5,144.4,116.7,172,118.7,131.5,1.0412126954050214,0.05826480760207523,0.8211434847282617,0.08558094862837048,0.9093019896125751,0.04129185864677756,7051]
["High","O75533-1","splicing factor 3B subunit 1 [OS=Homo sapiens]",49,55,274,55,1304,145.7,7.09,581.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101357717; LOC111145177; Sf3b1; SF3B1","ENSANAG00000021577; ENSCANG00000029415; ENSCATG00000035735; ENSCCAG00000020506; ENSCGRG00001016990; ENSCGRG00015028775; ENSCJAG00000003902; ENSCSAG00000011505; ENSDLEG00000016863; ENSFCAG00000005038; ENSG00000115524; ENSLAFG00000001956; ENSLCNG00005009987; ENSMMNG00015005194; ENSMMUG00000022430; ENSMNEG00000042333; ENSMPUG00000007799; ENSMUSG00000025982; ENSNLEG00000006861; ENSPANG00000013417; ENSPCTG00005000567; ENSPPAG00000035007; ENSRNOG00000013516; ENSRROG00000031308; ENSSBOG00000020080; ENSSSCG00000016075; ENSSSCG00070023758; ENSSSUG00005005995; ENSSTOG00000011034; ENSUMAG00000020945","mRNA processing; mRNA processing; mRNA processing","B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway","Spliceosome",13008,14007.9,14342.7,14551.2,14815.7,14641.3,0.9397930385700849,-0.089585013738686,0.0965923936212201,1.0150570717045377,0.2795379575220484,0.5535592123817878,2698]
["High","O75534","cold shock domain-containing protein E1 [OS=Homo sapiens]",47,39,211,39,798,88.8,6.25,409.73,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity","CSDE1","ENSG00000009307","","","",9348.3,9036.2,9112,9453,10213.1,10086.7,0.9241651205936919,-0.11377745387467147,0.04114510316195673,1.3856818444441183,0.17365457593976116,0.7603137681884967,1850]
["Low","O75541","zinc finger protein 821 [OS=Homo sapiens]",2,1,1,1,412,46.8,6.55,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF821","ENSG00000102984","","","",18.1,15.6,13.5,12.4,20,8.6,1.151219512195122,0.2031629498563954,0.5971848254919441,0.22389123625987617,0.7733984271755017,0.11159671546659336,6029]
["High","O75553-5","Isoform DAB553 of Disabled homolog 1 [OS=Homo sapiens]",17,6,6,6,553,59.6,5.36,7.81,"","","","DAB1","","","","",207.3,192.9,200.9,177.7,186.1,200.5,1.0652135388977495,0.09114267047726737,0.1933140728516654,0.7137365291098022,0.4161555778400341,0.38074428003160116,3627]
["High","O75554","WW domain-binding protein 4 [OS=Homo sapiens]",18,5,7,5,376,42.5,5.57,13.15,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","WBP4","ENSG00000120688","","mRNA Splicing - Major Pathway","",379.4,362.7,359.3,364.8,311.3,339,1.0850162545562012,0.11771665574990971,0.15909311858803563,0.7983486049158097,0.37483375676987996,0.4261613043404923,3314]
["High","O75569-1","Interferon-inducible double-stranded RNA-dependent protein kinase activator A [OS=Homo sapiens]",30,9,38,9,313,34.4,8.41,73.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function","PRKRA","ENSCATG00000032736; ENSG00000180228; ENSMNEG00000031681; ENSPANG00000001046; ENSPTRG00000012688","VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","",1973,2002.6,2038,1776.4,1676.3,1689.2,1.1695287734106072,0.22592735612911485,1.3664963235286041E-3,2.864391532411414,0.03355221161670233,1.4742788477372115,318]
["High","O75581","Low-density lipoprotein receptor-related protein 6 [OS=Homo sapiens]",11,13,17,13,1613,180.3,5.31,37.04,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","LRP6","ENSG00000070018; ENSG00000281324","MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Type I collagen synthesis in the context of osteogenesis imperfecta; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by WNT ligand antagonists; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","mTOR signaling pathway; Wnt signaling pathway; Parathyroid hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Pathways in cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer",699.3,649.2,717,713.9,704,699.9,0.9753045613372366,-0.03607529087737869,0.44758387906429103,0.349125564144367,0.6662983656308836,0.17633125201530825,5245]
["High","O75586","Mediator of RNA polymerase II transcription subunit 6 [OS=Homo sapiens]",9,2,3,2,246,28.4,8.62,2.57,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MED6","ENSG00000133997","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway","",109.3,123.8,104.5,102.4,113,114.9,1.0221011201937633,0.03153793442166009,0.7450968972269707,0.1277872451113541,0.8656028230245778,0.06268133585349796,6721]
["High","O75592-1","E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",3,13,16,13,4640,509.8,7.03,32.47,"","","","","","","","",882,872.4,883.7,789.2,807.9,761.9,1.118312844425604,0.16132383394601296,2.5311538671182092E-3,2.596681453573764,0.043724003085086234,1.3592800837265109,452]
["High","O75600-1","2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [OS=Homo sapiens]",3,1,1,1,419,45.3,8.05,2.88,"other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","GCAT","ENSG00000100116","","Threonine catabolism","Glycine, serine and threonine metabolism; Metabolic pathways",14.5,13.2,16.2,9.4,14.7,14.2,1.1462140992167102,0.19687654761040121,0.3814331425520284,0.4185815740007731,0.6134356286398018,0.2122310035861614,4855]
["High","O75607","Nucleoplasmin-3 [OS=Homo sapiens]",44,5,36,5,178,19.3,4.63,63.14,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NPM3","ENSG00000107833","","","",773.3,758,737.8,709.7,694.5,676.2,1.0907037108248414,0.12525924742010563,0.011215994949426534,1.9501621949406014,0.086365373338385,1.063660345279283,1014]
["High","O75608","Acyl-protein thioesterase 1 [OS=Homo sapiens]",56,8,40,8,230,24.7,6.77,72.67,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LYPLA1","ENSG00000120992","","RAS processing; eNOS activation","Glycerophospholipid metabolism; Choline metabolism in cancer",1502.2,1426.9,1482.2,1503.3,1509.9,1596.5,0.9569603227975791,-0.06346898552593609,0.15286162928274463,0.8157015157785569,0.36634241910364335,0.4361127910924121,3258]
["High","O75616-1","GTPase Era, mitochondrial [OS=Homo sapiens]",7,2,4,2,437,48.3,8.84,9.83,"cell organization and biogenesis","other membranes;cytosol;mitochondrion","translation activity;nucleic acid binding activity;other molecular function","ERAL1","ENSG00000132591","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",88.5,99.4,95.5,91.6,105.1,91.5,0.9833448993754337,-0.024230577256729086,0.7866644605036373,0.10421046970604741,0.8885109370190076,0.05133722192984536,6913]
["High","O75643-1","U5 small nuclear ribonucleoprotein 200 kDa helicase [OS=Homo sapiens]",49,87,348,87,2136,244.4,6.06,756.77,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","SNRNP200","ENSCATG00000015790; ENSG00000144028; ENSGGOG00000005174; ENSMLEG00000019083; ENSPPAG00000041559; ENSPPYG00000012068; ENSPTRG00000012230; ENSRBIG00000044690; ENSRROG00000037952","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",13779.7,14176.7,14301.8,13589.5,14386.9,13993,1.006881203924764,9.893478162301881E-3,0.7473161508881752,0.12649563173310394,0.8668911760711442,0.06203541763121445,6731]
["High","O75648-1","Mitochondrial tRNA-specific 2-thiouridylase 1 [OS=Homo sapiens]",14,4,4,4,421,47.7,8.03,6.21,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TRMU","ENSG00000100416","","tRNA modification in the mitochondrion","",101,106.8,105.7,106.5,122.2,118.7,0.9024179620034543,-0.14813231102099148,0.09017033404025354,1.0449363214576046,0.27016499162943197,0.5683709281755351,2606]
["High","O75663","TIP41-like protein [OS=Homo sapiens]",31,8,25,8,272,31.4,5.91,37.38,"stress response;signal transduction;other biological processes","cytosol","","TIPRL","ENSG00000143155","Ciliary landscape","","",1373.9,1323.8,1324.3,1283.5,1322.7,1282.1,1.0343852069027597,0.04877354793227017,0.10441802732542133,0.9812245157774454,0.2911771276274606,0.5358427424610293,2800]
["High","O75665","Oral-facial-digital syndrome 1 protein [OS=Homo sapiens]",9,7,7,7,1012,116.6,6.1,18.72,"cell organization and biogenesis;transport;developmental processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","OFD1","ENSG00000046651","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state","",142.4,172,165.2,184.3,192.5,178.4,0.8638328530259364,-0.21117590916403767,0.06258504748782372,1.2035294139013852,0.21883746116655958,0.6598783323141878,2233]
["High","O75674","TOM1-like protein 1 [OS=Homo sapiens]",11,4,5,4,476,53,5.24,16.3,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TOM1L1","ENSG00000141198","","","",155.5,149.7,153.9,169,187.8,190.9,0.8382326090925688,-0.2545774483161714,0.013864634843257635,1.8580915640700053,0.09717690202527435,1.01243695024908,1114]
["High","O75676","Ribosomal protein S6 kinase alpha-4 [OS=Homo sapiens]",3,2,3,2,772,85.6,8.28,4.53,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","RPS6KA4","ENSG00000162302","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Interferon type I signaling pathways","Recycling pathway of L1","MAPK signaling pathway; TNF signaling pathway",65.1,68.6,61.4,86.2,75,77.4,0.8176865046102263,-0.29038026508620174,0.022062313762284916,1.6563489433237788,0.1247375422562785,0.9040028172437746,1381]
["High","O75683","Surfeit locus protein 6 [OS=Homo sapiens]",25,6,19,6,361,41.4,10.64,38.08,"other biological processes","nucleus;other cell component","nucleic acid binding activity","SURF6","ENSG00000148296; ENSG00000281309","","","",509.3,524.9,518.6,592,497.7,480.8,0.9887297039159504,-0.01635191982566315,0.8739269245124438,0.05852488041802664,0.9395045334700759,0.027101119920786534,7263]
["High","O75688","Protein phosphatase 1B [OS=Homo sapiens]",29,13,39,1,479,52.6,5.05,86.64,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus","other molecular function","PPM1B","ENSG00000138032","MAPK signaling pathway","ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","MAPK signaling pathway",1251.3,1238.2,1225.5,1252.6,1239.8,1228.1,0.9985217040720334,-2.1343081627500423E-3,0.8670312084245984,0.06196526999476996,0.9349233082970948,0.02922401281670026,7241]
["High","O75688-2","Isoform Beta-2 of Protein phosphatase 1B [OS=Homo sapiens]",35,13,38,1,387,42.7,5.2,82.57,"","","","PPM1B","","","","",62,65.6,63.7,68.1,59.7,59.2,1.022994652406417,0.032798603571113284,0.6647271172013245,0.17735660404415124,0.8163242106177953,0.08813732296426988,6358]
["High","O75691","Small subunit processome component 20 homolog [OS=Homo sapiens]",20,40,75,40,2785,318.2,7.39,149.83,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","","UTP20","ENSG00000120800","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2474.8,2604.6,2473.7,2736.6,2798.4,2789,0.907388274867852,-0.1402080773623537,0.005661359193652409,2.247079289759043,0.06287893681939973,1.2014948101202314,703]
["High","O75694","nuclear pore complex protein nup155 [OS=Homo sapiens]",24,26,67,26,1391,155.1,6.16,169.68,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUP155","ENSG00000113569","","ISG15 antiviral mechanism; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis",3180.1,3204.3,3299.6,3211,3698.9,3316.9,0.9469237689208747,-0.07867980713090923,0.3013591098610561,0.520915675599461,0.538939974758389,0.2684596023139459,4366]
["High","O75695","Protein XRP2 [OS=Homo sapiens]",23,7,16,7,350,39.6,5.12,27.49,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","RP2","ENSG00000102218","Joubert syndrome; Ciliopathies","Trafficking of myristoylated proteins to the cilium","",955.2,864.3,845.3,716.4,646.2,688.2,1.2993953579091087,0.37784045627705565,6.6436749720525864E-3,2.177591622653048,0.06825501866024551,1.1658654102752037,760]
["High","O75717","WD repeat and HMG-box DNA-binding protein 1 [OS=Homo sapiens]",35,31,103,31,1129,125.9,5.62,237.63,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","WDHD1","ENSG00000198554","Mesodermal commitment pathway","","",3852.9,3832.2,3887.9,4326.9,4461.1,4327.5,0.8823910640082345,-0.18050991408531472,4.1328170356934015E-4,3.3837538209819296,0.0201681471341838,1.6953339989792187,160]
["High","O75718","Cartilage-associated protein [OS=Homo sapiens]",38,14,64,14,401,46.5,5.73,125.6,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cell component","","CRTAP","ENSG00000170275","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",3232.9,3258.3,3218.2,3270.6,3263.6,3253.1,0.992040705812635,-0.01152877581838571,0.11175362976357676,0.951738362060087,0.30171934342808,0.5203968460239449,2892]
["High","O75746","Calcium-binding mitochondrial carrier protein Aralar1 [OS=Homo sapiens]",10,6,15,2,678,74.7,8.38,27.89,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A12","ENSG00000115840","","Mitochondrial protein import; Gluconeogenesis; Aspartate and asparagine metabolism","",248.5,235.9,228,243.7,246.4,247.4,0.9659661016949153,-0.04995553292230942,0.2402217925560163,0.6193875966104064,0.4719808143627014,0.3260756547255673,3974]
["High","O75781","Paralemmin-1 [OS=Homo sapiens]",17,5,6,5,387,42.1,5,11.9,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","signal transduction activity or receptor binding","PALM","ENSG00000099864","","","",315.5,281.8,274.1,306.3,261.3,253.1,1.0617765322285853,0.08648015995571319,0.4632617637238971,0.3341735437187064,0.6787667200518275,0.16827945930098281,5329]
["High","O75787","Renin receptor [OS=Homo sapiens]",25,8,15,8,350,39,6.1,37.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ATP6AP2","ENSG00000182220","ACE inhibitor pathway; Oxidative phosphorylation","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","Renin-angiotensin system",815.9,775.5,798.9,775.4,729.3,729.5,1.0698684092740134,0.09743336021283308,0.054271720989041275,1.2654264064619203,0.20431706725286125,0.6896953538563072,2074]
["High","O75792","Ribonuclease H2 subunit A [OS=Homo sapiens]",21,7,11,7,299,33.4,5.25,31.7,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RNASEH2A","ENSG00000104889","","","DNA replication",408.3,381.4,366.5,416.9,400.5,405.1,0.9457668711656443,-0.08044348771008102,0.1686465073438487,0.7730226485868487,0.38536491932712047,0.414127822726976,3417]
["High","O75794","Cell division cycle protein 123 homolog [OS=Homo sapiens]",35,9,16,9,336,39.1,4.81,39.97,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","other cell component","","CDC123","ENSG00000151465","","","",672.9,669.6,688.6,797.3,793.1,767.1,0.8615482502651113,-0.21499649928574527,6.1059214996453956E-4,3.214248783478232,0.023143220907393812,1.63557619918875,206]
["High","O75808-1","Calpain-15 [OS=Homo sapiens]",9,5,5,5,1086,117.2,6.71,12.48,"protein metabolism","other cell component","other molecular function","CAPN15","ENSG00000103326","","Degradation of the extracellular matrix","",192.1,202.1,212.6,177.9,177,183.1,1.127881040892193,0.17361491280304672,0.021032861311626672,1.6771016418490368,0.12128846463898157,0.916180501539527,1354]
["High","O75815-1","Breast cancer anti-estrogen resistance protein 3 [OS=Homo sapiens]",6,4,4,4,825,92.5,7.96,3.91,"developmental processes;signal transduction;other biological processes","other membranes;other cell component","enzyme regulator activity;other molecular function","BCAR3","ENSG00000137936","","","",117.8,144,139.1,155.1,133.1,131.3,0.9556615017878426,-0.06542839317641508,0.6062549254831768,0.21734471997487606,0.7791997462012583,0.1083511975865905,6075]
["High","O75817","Ribonuclease P protein subunit p20 [OS=Homo sapiens]",11,1,4,1,140,15.6,8.94,11.68,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP7","ENSG00000172336","","tRNA processing in the nucleus","Ribosome biogenesis in eukaryotes",92.9,84.8,99.2,96.7,90.7,88.7,1.0028975009054688,0.004174165778860833,0.9584570315625955,0.018427352137559385,0.9810740039906589,0.008298231852891986,7628]
["High","O75818-1","Ribonuclease P protein subunit p40 [OS=Homo sapiens]",8,2,8,2,363,41.8,6.67,17.47,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP40","ENSG00000124787","","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","Ribosome biogenesis in eukaryotes",175,179.8,178.2,175.2,189.1,192.9,0.9565685570710697,-0.06405972495471465,0.22055789567542347,0.6564773904501219,0.45105187255990215,0.3457735098491345,3818]
["High","O75820-1","Zinc finger protein 189 [OS=Homo sapiens]",9,5,9,1,626,72.9,8.5,7.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF189","ENSG00000136870; ENSGGOG00000003650; ENSPPAG00000034345; ENSPPYG00000019452; ENSPTRG00000021200","","Generic Transcription Pathway","Herpes simplex virus 1 infection",119.1,133.6,129.8,129.5,142,160.4,0.88562167168326,-0.17523756873964555,0.17391672013520865,0.7596586634636897,0.3926957058460697,0.40594384774295805,3458]
["High","O75821","Eukaryotic translation initiation factor 3 subunit G [OS=Homo sapiens]",56,22,117,22,320,35.6,6.13,228.78,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3G","ENSG00000130811","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",4459.6,4198.4,4200.8,4463.7,4291.8,4530.1,0.9678749924730534,-0.04710736906647647,0.27300557009310555,0.5638284920214367,0.5087416446985604,0.2935027103290966,4190]
["High","O75822","Eukaryotic translation initiation factor 3 subunit J [OS=Homo sapiens]",40,8,12,8,258,29,4.83,19.73,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3J","ENSG00000104131","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","",666.5,656.1,498.7,1608.4,510.5,463.9,0.7051649372773734,-0.5039673531754393,0.5385719117031266,0.26875630021977576,0.7323527493169648,0.1352796837216276,5742]
["High","O75828","Carbonyl reductase [NADPH] 3 [OS=Homo sapiens]",35,6,16,4,277,30.8,6.18,47,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CBR3","ENSG00000159231","Nuclear receptors meta-pathway; NRF2 pathway","Phase I - Functionalization of compounds","Arachidonic acid metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways",239.2,241.1,235.1,270.1,242.5,272.4,0.9113375796178343,-0.13394253567112635,0.07639709924644326,1.1169231310208982,0.24669501692151735,0.6078396228870159,2418]
["High","O75832","26S proteasome non-ATPase regulatory subunit 10 [OS=Homo sapiens]",52,10,64,10,226,24.4,6.1,103.3,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PSMD10","ENSG00000101843","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway","Degradation of DVL; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","",2302.3,2173.1,2135.5,2173.9,2139.3,2187.8,1.0169050915243807,0.024185037723906535,0.5239821156862351,0.280683535900491,0.7228361058795272,0.140960162430127,5660]
["High","O75844","caax prenyl protease 1 homolog [OS=Homo sapiens]",16,7,48,7,475,54.8,7.49,80.53,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZMPSTE24","ENSG00000084073","Adipogenesis; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy","","Terpenoid backbone biosynthesis",1794.4,1841.2,1848.2,1751,1859.6,1847.1,1.0047822342745112,0.006882861031421251,0.8311754384018318,0.08030729885337705,0.9156063520092415,0.03829120307373596,7088]
["High","O75864-1","Protein phosphatase 1 regulatory subunit 37 [OS=Homo sapiens]",9,4,5,4,691,74.7,5.06,9.53,"other biological processes","","enzyme regulator activity","PPP1R37","ENSG00000104866; ENSPPAG00000031033","","","",117.1,130.1,146.6,112.9,116.8,118.8,1.1299856527977044,0.17630445514576812,0.15800464161332306,0.8013301548339057,0.37339595693608546,0.42783038882361485,3304]
["Medium","O75865-1","Trafficking protein particle complex subunit 6A [OS=Homo sapiens]",6,1,1,1,159,17.6,5.26,0,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC6A","ENSG00000007255","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",15.2,14.9,15.7,16.5,13.5,18.3,0.9482401656314701,-0.07667559073882908,0.5886515546629514,0.23014170464697034,0.7666707821198205,0.11539108742320243,5995]
["High","O75874","Isocitrate dehydrogenase [NADP] cytoplasmic [OS=Homo sapiens]",73,28,435,27,414,46.6,7.01,794.24,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","IDH1","ENSG00000138413","Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism","Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration","Citrate cycle (TCA cycle); Glutathione metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Peroxisome; Central carbon metabolism in cancer",14960.9,15060.5,14927.5,14493.7,14094.8,14528.3,1.042491557815051,0.060035700650586186,0.013477484114104259,1.8703911714014538,0.09557874292727163,1.0196386857145703,1101]
["High","O75879","Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial [OS=Homo sapiens]",13,5,11,5,557,61.8,8.63,16.71,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","other molecular function","GATB","ENSG00000059691","","","Aminoacyl-tRNA biosynthesis; Metabolic pathways",296,265,286.3,291.6,277.5,275.7,1.0029592803030305,0.004263034367440564,0.9402400870684062,0.026761236639075675,0.9730145261537596,0.01188067609204889,7545]
["High","O75880","Protein SCO1 homolog, mitochondrial [OS=Homo sapiens]",8,3,5,3,301,33.8,8.88,9.23,"cell organization and biogenesis;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO1","ENSG00000133028","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","",396.5,371.6,336.8,364.3,351.6,337.1,1.0492877492877493,0.06941036670781489,0.41433057950168267,0.38265301258935586,0.6399788654300966,0.1938343678577403,5055]
["High","O75882-1","Attractin [OS=Homo sapiens]",5,6,10,6,1429,158.4,7.31,11.5,"cell adhesion;stress response;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","ATRN","ENSG00000088812","","","",251.6,245.5,218.9,213.1,218.4,216.7,{"$f":"AVERAGE(T706:V706)/AVERAGE(W706:Y706)","v":1.1045973464979943},{"$f":"LOG(Z706,2)","v":0.14352056683377817},{"$f":"TTEST(T706:V706,W706:Y706,2,2)","v":0.09016553546851172},{"$f":"-LOG10(AB706)","v":1.0449594338116213},{"$f":"AB706*7808/AF706","v":0.27025431897817254},{"$f":"-LOG10(AD706)","v":0.5682273567885292},2605]
["High","O75884-1","Putative hydrolase RBBP9 [OS=Homo sapiens]",6,2,3,2,186,21,6.2,7.2,"other biological processes","nucleus","other molecular function","RBBP9","ENSG00000089050; ENSPPAG00000038694; ENSPTRG00000013289","","","",266.7,266.7,264.3,266.4,312.1,272.7,0.9371475563909775,-0.09365187292236574,0.2810269876286416,0.5512519718550466,0.517026088455333,0.2864875424257143,4244]
["High","O75886","Signal transducing adapter molecule 2 [OS=Homo sapiens]",17,8,16,7,525,58.1,5.07,18.11,"cell organization and biogenesis;other metabolic processes;transport;signal transduction","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STAM2","ENSG00000115145","EGF/EGFR signaling pathway","Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell","Endocytosis; JAK-STAT signaling pathway",503.7,467.4,482.2,439.2,430.8,462.1,1.0909841603483224,0.1256301557835982,0.04559582682632533,1.3410749044679344,0.18408077345395457,0.7349915695562819,1934]
["High","O75907","Diacylglycerol O-acyltransferase 1 [OS=Homo sapiens]",10,4,6,4,488,55.2,9.32,20.93,"cell organization and biogenesis;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","DGAT1","ENSG00000185000; ENSG00000285482","Triacylglyceride synthesis; Statin inhibition of cholesterol production; Glycerolipids and glycerophospholipids; Congenital generalized lipodystrophy (CGL); Vitamin A and carotenoid metabolism","Neutrophil degranulation; Acyl chain remodeling of DAG and TAG; Triglyceride biosynthesis","Glycerolipid metabolism; Retinol metabolism; Metabolic pathways; Fat digestion and absorption",340.9,349.8,383,255,272.1,265.3,1.354997476022211,0.43829016424805395,2.411350158545203E-3,2.617739719990835,0.042887977307337004,1.3676644355743215,439]
["High","O75909","Cyclin-K [OS=Homo sapiens]",18,7,20,7,580,64.2,8.41,44.16,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNK","ENSG00000090061","Male infertility","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes","",811.6,837.1,820.2,799.5,799.4,804.6,1.0272103182858332,0.03873159945859795,0.04701297800414085,1.3277822378608428,0.18690291866412004,0.7283839166531383,1964]
["High","O75915","PRA1 family protein 3 [OS=Homo sapiens]",20,3,9,3,188,21.6,9.77,6.29,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","ARL6IP5","ENSG00000144746","","Glutamate Neurotransmitter Release Cycle","",103.4,109.3,112.2,106.9,110.7,116.4,0.9727544910179641,-0.03985235903193122,0.4677726308051891,0.3299651921848496,0.6825581576017411,0.16586033850046897,5351]
["High","O75923-1","dysferlin [OS=Homo sapiens]",16,24,35,24,2080,237.1,5.64,65.88,"cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYSF","ENSG00000135636","","Smooth Muscle Contraction","",895.1,875.9,893.8,884.2,916.2,875,0.9960379756298124,-0.005727346360709411,0.8123755426615029,0.09024315991892672,0.9056293885067125,0.04304949267169988,7004]
["High","O75925","E3 SUMO-protein ligase PIAS1 [OS=Homo sapiens]",11,5,9,4,651,71.8,7.3,16,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS1","ENSG00000033800","Androgen receptor signaling pathway; Interleukin-11 signaling pathway; Mesodermal commitment pathway; TGF-beta signaling pathway; Immune response to tuberculosis; Interferon type I signaling pathways","SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway; Hepatitis C",180.9,191,189,195.2,210,189.5,0.9431646208172187,-0.08441849269441887,0.17512075579394465,0.756662377088644,0.39404693407467434,0.4044520472208823,3470]
["High","O75928-1","E3 SUMO-protein ligase PIAS2 [OS=Homo sapiens]",10,4,7,3,621,68.2,7.52,10.59,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS2","ENSG00000078043; ENSPTRG00000009998","Androgen receptor signaling pathway; TGF-beta signaling pathway","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway",33.2,37.4,34,38.1,29.7,24.5,1.133261105092091,0.1804802986011673,0.3807565470420221,0.41935262031029813,0.6128524261604017,0.21264409027772632,4851]
["High","O75934","Pre-mRNA-splicing factor spf27 [OS=Homo sapiens]",48,10,26,10,225,26.1,5.66,64.74,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","","BCAS2","ENSG00000116752","","mRNA Splicing - Major Pathway","Spliceosome",1210.5,1174.9,1149.9,1218.6,1133.7,1107.7,1.0217630057803468,0.031060607200403323,0.543207633823203,0.2650341354433182,0.7353268385734343,0.1335195824960555,5768]
["High","O75935","Dynactin subunit 3 [OS=Homo sapiens]",24,4,11,4,186,21.1,5.47,18.4,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DCTN3","ENSG00000137100","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection",330.8,313.1,324,276.3,273.5,294.5,1.1463934620395595,0.19710228694751705,0.007887317853703663,2.1030706570403357,0.0751026558557539,1.124344704765417,820]
["High","O75937","DnaJ homolog subfamily C member 8 [OS=Homo sapiens]",16,4,8,4,253,29.8,9.06,12.9,"","non-structural extracellular;cytosol;nucleus","other molecular function","DNAJC8","ENSG00000126698; ENSG00000285317","mRNA processing","mRNA Splicing - Major Pathway","",612.9,606.6,482.3,1255.9,544.5,430.9,0.7626943934029489,-0.39082300039965717,0.5369112370933734,0.27009750652926534,0.7307308591990691,0.13624255175307098,5737]
["High","O75940","Survival of motor neuron-related-splicing factor 30 [OS=Homo sapiens]",37,7,16,7,238,26.7,7.24,32.33,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","SMNDC1","ENSG00000119953","","mRNA Splicing - Major Pathway","Spliceosome",821.2,759.8,788.5,941.3,822.8,778.3,0.9319933920704847,-0.1016083688285557,0.3280371894020733,0.4840769177622619,0.565536404250693,0.24753943378658375,4529]
["High","O75943-1","cell cycle checkpoint protein RAD17 [OS=Homo sapiens]",9,6,8,6,681,77,7.06,13.11,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","RAD17","ENSG00000152942; ENSG00000276618","miRNA regulation of DNA damage response; Gastric cancer network 2; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","",231.5,244.7,230.8,233.2,233.8,221.1,1.027466937945066,0.03909197129857636,0.3620372990699332,0.4412466837602602,0.597755811194341,0.22347619311705108,4729]
["High","O75947-1","ATP synthase subunit d, mitochondrial [OS=Homo sapiens]",41,6,20,6,161,18.5,5.3,16.06,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5PD","ENSG00000167863; ENSGGOG00000013716; ENSPTRG00000009628","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",662.3,597.7,473,744.8,500.7,463.6,1.0139839681703822,0.02003484245572229,0.9427506979085413,0.02560313741853297,0.9732906848168571,0.011757433156005923,7563]
["High","O75953","dnaJ homolog subfamily B member 5 [OS=Homo sapiens]",30,8,18,8,348,39.1,9.04,37.35,"stress response;other biological processes","cytosol","other molecular function","DNAJB5","ENSG00000137094","","","",368.2,379.1,377.1,373.6,392.9,329.2,1.0261933010860638,0.03730251286623124,0.6436727837271916,0.19133485365957162,0.8049002394846111,0.09425794339131616,6244]
["High","O75954","tetraspanin-9 [OS=Homo sapiens]",14,2,3,2,239,26.8,7.68,9.46,"","plasma membrane;other membranes","","TSPAN9","ENSG00000011105","","","",28,24.3,25.5,23.7,22.9,28.2,1.0401069518716577,0.05673188509855519,0.6396022222274631,0.19409003601484576,0.8018648283802235,0.09589883525229301,6228]
["High","O75955","Flotillin-1 [OS=Homo sapiens]",34,13,37,12,427,47.3,7.49,78.73,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","FLOT1","ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules","Insulin signaling pathway",972,967.9,929.3,996.9,1135,988.9,0.9193796462445527,-0.12126736759177795,0.16436570380885274,0.7841887962874514,0.38014437658161204,0.4200514295824334,3376]
["High","O75962-1","Triple functional domain protein [OS=Homo sapiens]",5,12,14,12,3097,346.7,6.37,23.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;kinase activity;other molecular function","TRIO","ENSG00000038382","Microtubule cytoskeleton regulation; Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; G alpha (q) signalling events; DCC mediated attractive signaling","",355.9,358.2,326.8,325.7,336.4,315,1.0652952614880769,0.0912533489929631,0.14699241114534545,0.8327050862230886,0.36001152641871303,0.443683594288528,3188]
["High","O75964","ATP synthase subunit g, mitochondrial [OS=Homo sapiens]",39,4,21,4,103,11.4,9.64,39.98,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5MG","ENSG00000167283","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis",694.8,670.7,665.6,598.7,698.4,654.3,1.0408424720713334,0.057751738225714964,0.42894799994879357,0.3675953528131699,0.6502088882935703,0.1869470980351134,5151]
["Low","O75969","A-kinase anchor protein 3 [OS=Homo sapiens]",1,1,1,1,853,94.7,6.18,0,"developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","AKAP3","ENSG00000111254","G protein signaling pathways","","",40.9,32.1,40.3,29.9,32.5,36.6,1.1444444444444444,0.19464743085354358,0.23855613772728637,0.6224094051507448,0.47084082997337007,0.32712588341725124,3956]
["High","O75970","multiple PDZ domain protein [OS=Homo sapiens]",11,16,24,16,2070,221.5,5.06,47.36,"","plasma membrane;other membranes;other cell component","other molecular function","MPDZ","ENSG00000107186","","","Tight junction",1281.7,1265.5,1276.8,1440,1353.4,1394.2,0.9131722227528895,-0.13104111914663225,0.008913427802940237,2.049955248867941,0.07872855688388843,1.103867709222379,884]
["High","O75976","Carboxypeptidase D [OS=Homo sapiens]",15,16,26,16,1380,152.8,6.05,45.84,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","CPD","ENSG00000108582","","Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle; RND1 GTPase cycle","",794.2,740.5,757.7,747.8,742,716.9,1.0388362713554176,0.05496829224316862,0.19654924114926295,0.7065286285944588,0.42010853405240767,0.37663849614774,3653]
["High","O76003","glutaredoxin-3 [OS=Homo sapiens]",36,11,67,11,335,37.4,5.39,164.17,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","GLRX3","ENSG00000108010","","Iron uptake and transport","",3370.1,3252,3404.1,3385.1,3507.9,3459.3,0.9684997536779268,-0.04617641298467595,0.13570578525686877,0.8674016375902365,0.3419137693725819,0.46608340917088414,3099]
["High","O76021","Ribosomal L1 domain-containing protein 1 [OS=Homo sapiens]",48,24,127,24,490,54.9,10.13,233.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RSL1D1","ENSG00000171490","","","",5982.7,6031.1,6019.5,6517.9,6465,6718.9,0.9153123064897624,-0.12766401690188808,2.1156372059074166E-3,2.6745588040191888,0.04098981464944196,1.3873240455016629,403]
["High","O76024","Wolframin [OS=Homo sapiens]",18,14,33,14,890,100.2,8.05,64.28,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","WFS1","ENSG00000109501","CAMKK2 pathway","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes","Protein processing in endoplasmic reticulum",1188.6,1355,1330.9,1179.5,1300.2,1231.3,1.044058205335489,0.06220214314163031,0.43304044607402997,0.3634715385509551,0.6537470616678318,0.18459025010067612,5172]
["High","O76031","ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial [OS=Homo sapiens]",39,20,48,20,633,69.2,7.58,90.67,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","CLPX","ENSG00000166855","","","",2441.7,2401.7,2397.6,2422.2,2394,2405.8,1.0026308501800054,3.7905305324838654E-3,0.7169219567618501,0.14452811851968547,0.8496852820881186,0.07074190435876684,6588]
["High","O76039-1","Cyclin-dependent kinase-like 5 [OS=Homo sapiens]",3,2,2,1,1030,115.5,9.54,2.72,"","","","CDKL5","","","","",17.4,22.1,18,22.2,23.9,26.5,0.7920110192837466,-0.336407592164013,0.059976793727347405,1.2220167547108607,0.21521084808048188,0.6671358410783677,2176]
["High","O76041-2","Isoform 2 of Nebulette [OS=Homo sapiens]",10,3,3,2,270,31.2,8.31,7.4,"","","","NEBL","","","","",86,91.1,89.9,115.6,105.2,109.5,0.8083560399636693,-0.30693722771060894,0.003382529601836341,2.4707583940332447,0.05059538530869378,1.2958890923768713,522]
["High","O76062","Delta(14)-sterol reductase [OS=Homo sapiens]",5,2,3,2,418,46.4,8.87,8.9,"other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","TM7SF2","ENSG00000149809","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Steroid biosynthesis; Metabolic pathways",206.1,241.4,219.9,207.7,215.2,209.1,1.0560126582278482,0.07862712811785427,0.3250111898407797,0.48810168639821566,0.5623060869215174,0.25002721525972604,4513]
["High","O76064","E3 ubiquitin-protein ligase RNF8 [OS=Homo sapiens]",11,4,5,4,485,55.5,7.33,9.64,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","RNF8","ENSG00000112130","ATM signaling in development and disease ; 3q29 copy number variation syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome","Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Nonhomologous End-Joining (NHEJ)","",131.3,124.9,135.7,146.8,132,120.6,0.9812218327491239,-0.02734875984176268,0.7758492415814326,0.11022266006924451,0.8828083471681472,0.054133569130763705,6862]
["High","O76070","Gamma-synuclein [OS=Homo sapiens]",76,8,15,7,127,13.3,4.86,35.71,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","cytoskeleton;other cell component","other molecular function","SNCG","ENSG00000173267","","","",570.5,573.9,587.1,614.5,568.4,604.7,0.9686171402998432,-0.046001562310419485,0.27800037129787386,0.5559546240369234,0.5137578459393608,0.28924153266399916,4225]
["High","O76071","Probable cytosolic iron-sulfur protein assembly protein Ciao1 [OS=Homo sapiens]",33,8,19,8,339,37.8,4.97,62.4,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","","CIAO1","ENSG00000144021","","Cytosolic iron-sulfur cluster assembly","",684.2,638.8,682.1,635,610.1,632.8,1.0677352361680603,0.09455394962661869,0.0650969359513285,1.18643945276433,0.2237134136918895,0.6503079751446759,2272]
["High","O76074","cGMP-specific 3',5'-cyclic phosphodiesterase [OS=Homo sapiens]",8,6,8,6,875,99.9,6.09,8.24,"other metabolic processes;signal transduction","cytosol","other molecular function","PDE5A","ENSG00000138735","Phosphodiesterases in neuronal function","cGMP effects; RHOBTB1 GTPase cycle","Purine metabolism; Metabolic pathways; cGMP-PKG signaling pathway",71.1,77.9,67.9,80.7,78.9,77.3,0.9155761924862809,-0.12724814556795772,0.09850958101641231,1.0065215280789945,0.2822615811288614,0.5493482300330204,2725]
["High","O76075","DNA fragmentation factor subunit beta [OS=Homo sapiens]",12,3,4,3,338,39.1,9,5.11,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DFFB","ENSG00000169598","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis","Apoptosis induced DNA fragmentation","Apoptosis",141.7,146.7,138.9,159.7,151.1,155.6,0.9161663807890221,-0.1263184715193851,0.018072452782624274,1.742982901248168,0.1119918343862939,0.9508136417070954,1260]
["High","O76080","AN1-type zinc finger protein 5 [OS=Homo sapiens]",29,4,5,4,213,23.1,8.51,17.66,"developmental processes;signal transduction;other biological processes","other cell component","nucleic acid binding activity;other molecular function","ZFAND5","ENSG00000107372","","","",279.9,273.2,291.3,305.8,327.4,310.9,0.8943967800021184,-0.161013100672424,0.016667629527954118,1.7781261611877204,0.10737694006127536,0.9690889763593524,1212]
["High","O76094","Signal recognition particle subunit SRP72 [OS=Homo sapiens]",36,20,56,20,671,74.6,9.26,128.38,"transport","cytosol;ER/Golgi;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","SRP72","ENSG00000174780","","SRP-dependent cotranslational protein targeting to membrane","Protein export",2115.4,2235.9,2214,2171,2504.1,2328.6,0.9374045147564857,-0.0932563517014176,0.22931800837206984,0.6395618387305043,0.46076042443878573,0.33652483033563263,3886]
["Medium","O76095-1","Protein JTB [OS=Homo sapiens]",9,1,2,1,146,16.3,8.28,2.18,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","other molecular function","JTB","ENSG00000143543; ENSGGOG00000005608; ENSPPAG00000028370; ENSPTRG00000001369","","","",42.3,45.9,38.4,45.2,36.3,43.3,1.0144230769230769,0.0206594705660929,0.8709725204537825,0.059995546948192396,0.9376193905560641,0.02797341975130333,7253]
["High","O77932","Decapping and exoribonuclease protein [OS=Homo sapiens]",4,2,3,2,396,44.9,7.69,4.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","DXO","ENSG00000204348; ENSG00000206346; ENSG00000224313; ENSG00000225682; ENSG00000234798; ENSG00000236765","","","",79.2,75,88.4,87.4,81.7,103.5,0.8899486426999265,-0.1682060116846995,0.260340567890738,0.5844581521431141,0.4954275296346289,0.3050198644513914,4103]
["High","O94760-1","N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [OS=Homo sapiens]",29,7,24,6,285,31.1,5.81,61.15,"other metabolic processes;signal transduction;other biological processes","cytosol","other molecular function","DDAH1","ENSG00000153904; ENSMFAG00000037521; ENSMMUG00000014573; ENSMNEG00000044101; ENSRBIG00000034663; ENSRROG00000009892","Mesodermal commitment pathway; Nitric oxide metabolism in cystic fibrosis","eNOS activation","",941.3,942.5,962.2,930.2,896.2,923,1.0351349385320432,0.04981884739772302,0.05979830389174829,1.2233111340868545,0.21496554179869734,0.6676311503450285,2172]
["High","O94761","ATP-dependent DNA helicase Q4 [OS=Homo sapiens]",6,5,7,5,1208,133,8.09,14.84,"","","","","","","","",145.3,128.7,136.5,124.1,122,111.5,1.147930648769575,0.19903548548184954,0.046222067013484386,1.3351506371243707,0.1858403188678095,0.7308600580377214,1942]
["High","O94762-1","ATP-dependent DNA helicase Q5 [OS=Homo sapiens]",9,8,9,8,991,108.8,8.56,13.93,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RECQL5","ENSG00000108469","","","",361.2,358.6,377.8,391.4,388.5,404.5,0.9267139479905436,-0.10980400900474169,0.02041631954297228,1.6900225456105984,0.11949821813457838,0.9226385705324932,1334]
["High","O94763-1","Unconventional prefoldin RPB5 interactor 1 [OS=Homo sapiens]",19,9,15,9,535,59.8,5.05,26.66,"other biological processes","cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","URI1","ENSG00000105176","","","",535.5,569.5,564.2,553.2,584.9,564.1,0.9806133239337328,-0.02824373073211985,0.47806020653635567,0.3205174052289795,0.6903447554347818,0.1609339701459687,5407]
["High","O94766","Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 [OS=Homo sapiens]",26,8,12,8,335,37.1,8.27,26.73,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","B3GAT3","ENSG00000149541","Proteoglycan biosynthesis","A tetrasaccharide linker sequence is required for GAG synthesis; Defective B3GAT3 causes JDSSDHD","Glycosaminoglycan biosynthesis; Glycosaminoglycan biosynthesis; Metabolic pathways",480.3,502,517.3,443.8,464.7,448.4,1.1051661876335763,0.1442633289355228,0.01885211294556936,1.7246399669873758,0.11463964009268346,0.9406651860615749,1284]
["High","O94768","Serine/threonine-protein kinase 17B [OS=Homo sapiens]",5,2,2,2,372,42.3,5.25,2.06,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus","kinase activity;other molecular function","STK17B","ENSG00000081320","","","",50.3,57,51.9,53.3,52,46.3,1.050131926121372,0.07057058237255705,0.4388833841084679,0.35765086100192384,0.6590002813690226,0.18111439997808756,5200]
["High","O94776","Metastasis-associated protein MTA2 [OS=Homo sapiens]",34,22,66,20,668,75,9.66,131.78,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MTA2","ENSG00000149480","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","",2300.3,2276.1,2269.8,2215.4,2237.8,2241.8,1.0225840179238235,0.032219383276918645,0.015315971931954392,1.8148554382115591,0.10203678229069955,0.9912432452349956,1172]
["High","O94782","Ubiquitin carboxyl-terminal hydrolase 1 [OS=Homo sapiens]",11,7,7,7,785,88.2,5.45,13.61,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus","other molecular function","USP1","ENSG00000162607","miR-517 relationship with ARCN1 and USP1; DNA repair pathways, full network","Fanconi Anemia Pathway; Recognition of DNA damage by PCNA-containing replication complex","Fanconi anemia pathway",352,356.5,350,383.8,364.4,376.6,0.9410561877667138,-0.08764723017758394,0.020907150101742072,1.679705162755738,0.12128010995126456,0.9162104179850606,1346]
["High","O94788-1","retinal dehydrogenase 2 [OS=Homo sapiens]",5,5,11,2,518,56.7,6.05,23.03,"cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","ALDH1A2","ENSG00000128918","Ethanol effects on histone modifications; Tryptophan metabolism; 22q11.2 copy number variation syndrome; Vitamin A and carotenoid metabolism","RA biosynthesis pathway","Retinol metabolism; Metabolic pathways",409.6,389.6,396.7,438.5,410,423.4,0.9402468747543047,-0.08888848892511433,0.06620298241795296,1.1791224453264018,0.2251362747035613,0.6475545243937023,2296]
["High","O94804","Serine/threonine-protein kinase 10 [OS=Homo sapiens]",13,10,11,9,968,112.1,6.95,16.66,"cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","kinase activity;other molecular function","STK10","ENSG00000072786","","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation","Progesterone-mediated oocyte maturation",155.4,212.1,193.7,202.2,193.9,198.4,0.9439865433137091,-0.08316180101311883,0.5465403811258849,0.26237774468910485,0.7379192972213228,0.13199113233406404,5783]
["High","O94808","Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [OS=Homo sapiens]",42,25,94,18,682,76.9,7.37,224.33,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","GFPT2","ENSG00000131459","","Synthesis of UDP-N-acetyl-glucosamine","Alanine, aspartate and glutamate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars; Insulin resistance; Diabetic cardiomyopathy",2207.8,2266,2311.5,1625.7,1771.2,1741.6,1.3204826311180307,0.40106532523489485,5.1197279487190644E-4,3.2907531158814303,0.022208242124221365,1.653485816326101,180]
["High","O94819","Kelch repeat and BTB domain-containing protein 11 [OS=Homo sapiens]",6,2,3,2,623,65.7,6.07,7.41,"","","","KBTBD11","ENSG00000176595; ENSG00000273645","","","",36.2,40.1,38.6,39.9,43.3,37.7,0.9503722084367248,-0.07343544660300998,0.3708382090911088,0.4308155249522399,0.6049947213922644,0.21824841457102306,4786]
["High","O94822","E3 ubiquitin-protein ligase listerin [OS=Homo sapiens]",18,25,40,25,1766,200.4,6.25,71.97,"protein metabolism;other metabolic processes","cytosol;other cell component","translation activity;other molecular function","LTN1","ENSG00000198862","","Antigen processing: Ubiquitination & Proteasome degradation","",1912.9,1897.1,1966.7,1981.7,1911.7,1931.2,0.9917762593139442,-0.011913403696066095,0.6187393162403501,0.20849228694794292,0.7883675883166862,0.10327123891385506,6128]
["High","O94826","Mitochondrial import receptor subunit TOM70 [OS=Homo sapiens]",48,25,95,25,608,67.4,7.12,193.99,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TOMM70","ENSG00000154174","Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation","Mitochondrial protein import; Ub-specific processing proteases; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PINK1-PRKN Mediated Mitophagy","",3414.8,3614.7,3577.8,3497.8,3403.8,3516,1.0182095684226693,0.026034528218860688,0.42089398693667807,0.3758272787159216,0.6433712314020326,0.1915383626486639,5108]
["High","O94829","Importin-13 [OS=Homo sapiens]",10,7,10,7,963,108.1,5.3,17.08,"transport","nucleus;other cell component","other molecular function","IPO13","ENSG00000117408","","","Nucleocytoplasmic transport",311.6,312.1,346.2,302.5,317.1,307,1.0467299805741421,0.06588932581397039,0.303585477576704,0.517719007345566,0.53995339610909,0.267643722929052,4390]
["High","O94830","Phospholipase DDHD2 [OS=Homo sapiens]",14,6,6,6,711,81,5.39,5.24,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","DDHD2","ENSG00000085788","","Synthesis of PA","",125.6,134,112.6,115.7,130.3,135.5,0.9756225425950197,-0.03560500166274129,0.7365856409530751,0.13277675156259852,0.8608383003385137,0.06507841865766377,6681]
["High","O94832","Unconventional myosin-Id [OS=Homo sapiens]",8,7,8,7,1006,116.1,9.39,14.9,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1D","ENSG00000176658","","","Pathogenic Escherichia coli infection",363.1,349.7,363.7,264.6,300.5,308.5,1.232257326007326,0.3013035581347436,0.008999537039158066,2.045779831284061,0.07895324179971482,1.1026300332703385,890]
["High","O94842","TOX high mobility group box family member 4 [OS=Homo sapiens]",9,4,7,4,621,66.2,5.06,12.49,"other biological processes","nucleus;other cell component","nucleic acid binding activity","TOX4","ENSG00000092203","","","",246.6,246.5,268.1,217.6,243,233.7,1.096356042056748,0.13271639017337264,0.09695772208498799,1.0134175963289953,0.2795590450663169,0.5535264516834666,2708]
["High","O94854","Uncharacterized protein KIAA0754 [OS=Homo sapiens]",9,7,11,7,1291,135.1,4.21,28.81,"","","","KIAA0754","","","","",198.7,190.8,190.9,197.7,163.4,179.6,1.073423340114666,0.10221916298474491,0.2661029845747382,0.5749502544336894,0.5018676578646271,0.2994107908959529,4140]
["High","O94855","Protein transport protein Sec24D [OS=Homo sapiens]",18,15,33,15,1032,112.9,7.25,62.42,"cell organization and biogenesis;transport;developmental processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC24D","ENSG00000150961","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",1370.8,1347.6,1272.9,1348.2,1492.3,1417.2,0.9374310073513867,-0.09321557934049754,0.15679458980814193,0.8046689267090181,0.3720000477733127,0.42945700434475637,3291]
["Low","O94856","Neurofascin [OS=Homo sapiens]",1,1,2,1,1347,149.9,6.65,0,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","NFASC","ENSG00000163531","","Neutrophil degranulation; Neurofascin interactions; Interaction between L1 and Ankyrins","Cell adhesion molecules",98.3,105.2,99.2,105,100,106.8,0.9708146247594611,-0.04273225287027141,0.3650104671959403,0.43769468135103773,0.5997478383556191,0.2220313086655395,4752]
["High","O94864-1","STAGA complex 65 subunit gamma [OS=Homo sapiens]",17,3,9,3,414,46.2,5.12,0,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SUPT7L","ENSG00000119760; ENSPTRG00000011777","","HATs acetylate histones","",58.2,61.2,60.4,55.7,54.3,53.9,1.0970103721781574,0.13357716641498854,0.007239951063826696,2.1402643692699606,0.07155637709665677,1.1453516559017665,790]
["High","O94874-1","E3 UFM1-protein ligase 1 [OS=Homo sapiens]",16,11,28,11,794,89.5,6.79,48.52,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UFL1","ENSG00000014123","","Antigen processing: Ubiquitination & Proteasome degradation","",1534.6,1453.6,1481.2,1312.5,1415,1346.3,1.0971083509254258,0.13370601400322715,0.026438863657031308,1.5777572147721077,0.13698384036768443,0.8633306624281042,1507]
["High","O94875-1","Sorbin and SH3 domain-containing protein 2 [OS=Homo sapiens]",1,1,1,1,1100,124,8.31,2.53,"cell organization and biogenesis;developmental processes;signal transduction","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SORBS2","ENSG00000154556","Extracellular vesicles in the crosstalk of cardiac cells","","",37.6,41.5,38,37.4,33,41.8,1.0436720142602496,0.06166839989242229,0.5942972332076332,0.2259962916254428,0.7710656026728481,0.11290867037086914,6018]
["High","O94876","Transmembrane and coiled-coil domains protein 1 [OS=Homo sapiens]",15,7,9,6,653,72,6.55,15.21,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TMCC1","ENSG00000172765","","","",263.2,246.7,265.7,256.8,218,233.3,1.0953255189944922,0.13135968703964732,0.15265398948064465,0.8162918413044657,0.36595712307794703,0.43656979521070344,3257]
["High","O94880","PHD finger protein 14 [OS=Homo sapiens]",14,9,18,9,888,100,5.33,23.63,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF14","ENSG00000106443","","","",463.1,502.9,513.7,555.1,538.2,542.8,{"$f":"AVERAGE(T770:V770)/AVERAGE(W770:Y770)","v":0.9044068210989549},{"$f":"LOG(Z770,2)","v":-0.14495622185085533},{"$f":"TTEST(T770:V770,W770:Y770,2,2)","v":0.03228818010394648},{"$f":"-LOG10(AB770)","v":1.4909564329353795},{"$f":"AB770*7808/AF770","v":0.15251428327381375},{"$f":"-LOG10(AD770)","v":0.8166894818481916},1653]
["High","O94885","SAM and SH3 domain-containing protein 1 [OS=Homo sapiens]",7,6,7,6,1247,136.6,6.09,16.32,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","SASH1","ENSG00000111961","","","",266.9,276.3,276.9,327.3,265,292.2,0.9271905031091012,-0.10906230549247199,0.3063469710528778,0.5137864093144796,0.5430095686676208,0.2651925174039109,4405]
["High","O94887-1","FERM, RhoGEF and pleckstrin domain-containing protein 2 [OS=Homo sapiens]",6,4,6,4,1054,119.8,8.79,7.26,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity","FARP2","ENSG00000006607","","RAC1 GTPase cycle; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Rap1 signaling pathway; Adherens junction",155.4,151.1,151.1,142.8,148.5,133.5,1.0772128060263655,0.10730328597423598,0.07627403787786978,1.1176232618496642,0.2466035974121769,0.6080005922785598,2415]
["High","O94888","UBX domain-containing protein 7 [OS=Homo sapiens]",41,15,50,15,489,54.8,5.16,88.4,"","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","UBXN7","ENSG00000163960","3q29 copy number variation syndrome","Neddylation","",1978.9,1892.5,1925.5,2011.9,1839.6,1967.7,0.9961678581248281,-0.005539232433375186,0.9033340457820569,0.044151621322274494,0.9540419625951981,0.0204325228611565,7393]
["High","O94889","Kelch-like protein 18 [OS=Homo sapiens]",8,4,7,3,574,63.6,5.6,13.5,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","","","KLHL18","ENSG00000114648","","","",67,54.6,55,53.9,53,57.9,1.0716019417475728,0.09976910046524766,0.4158462935180463,0.3810671650759493,0.6406724269512442,0.19336396662871763,5068]
["High","O94898","Leucine-rich repeats and immunoglobulin-like domains protein 2 [OS=Homo sapiens]",2,1,1,1,1065,118.9,5.55,3.51,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","LRIG2","ENSG00000198799","","","Axon guidance",49.7,55.4,50.3,47.7,51.9,60.7,0.9694323144104801,-0.04478792174683841,0.7194141733855003,0.1430210102727518,0.8510887675445434,0.07002514115598504,6600]
["High","O94901-1","SUN domain-containing protein 1 [OS=Homo sapiens]",28,15,51,14,812,90,7.08,133.9,"","","","","","","","",1890.8,1897.7,1934.4,1698.3,1756.3,1761.3,1.0972027837957017,0.1338301876735625,2.255817264434014E-3,2.646696083882952,0.04183710498978808,1.3784383750599851,421]
["High","O94903","Pyridoxal phosphate homeostasis protein [OS=Homo sapiens]",42,11,47,11,275,30.3,7.5,93.29,"","cytosol;other cell component","other molecular function","PLPBP","ENSG00000147471","","","",2388.6,2374.1,2439.4,2115.7,2138,2148,1.1250292890950842,0.16996256115981223,2.6427733731221759E-4,3.577940077512412,0.01705353264242806,1.7681856431702268,121]
["High","O94905-1","Erlin-2 [OS=Homo sapiens]",52,18,80,15,339,37.8,5.62,160.07,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ERLIN2","ENSG00000147475; ENSGGOG00000012855; ENSPPAG00000034728; ENSPTRG00000020158","","ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions","",3340.3,3400.7,3449,3332.9,3695.8,3558.8,0.9624557260920897,-0.05520791805374713,0.29619908487690233,0.5284162875890356,0.5333769498890345,0.2729657564607307,4336]
["High","O94906-1","Pre-mRNA-processing factor 6 [OS=Homo sapiens]",48,43,144,43,941,106.9,8.25,301.32,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PRPF6","ENSG00000101161; ENSGGOG00000016876; ENSPPAG00000008686; ENSPTRG00000013765","mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",5644.9,5870.6,5926.3,5843.1,5738.8,5869.5,0.999449900867552,-7.9384365675764287E-4,0.9746989426837704,0.01112950504118546,0.9874723426073543,0.005475059368558675,7707]
["High","O94913","Pre-mRNA cleavage complex 2 protein Pcf11 [OS=Homo sapiens]",10,12,21,12,1555,172.9,8.48,42.05,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCF11","ENSG00000165494","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",773,836.6,829,858.9,815.9,786.3,0.9908577465361017,-0.013250144537270171,0.8092818763619389,0.09190018540027575,0.9030831628746633,0.04427225465378097,6997]
["High","O94915-1","protein furry homolog-like [OS=Homo sapiens]",4,9,9,9,3013,339.4,5.58,17.4,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","","FRYL","ENSG00000075539","","","",346.5,404.1,374.8,361.3,360.6,395,1.0076103500761036,0.010937846484888184,0.8948894399654612,0.04823061672751392,0.9509113700667285,0.021859959702649225,7348]
["High","O94916","nuclear factor of activated T-cells 5 [OS=Homo sapiens]",2,4,5,4,1531,165.7,5.24,8.46,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFAT5","ENSG00000102908","Cancer immunotherapy by PD-1 blockade","","",367.4,391.3,358.9,384.6,382,405.2,0.9537463731012118,-0.06832242919848477,0.21160297547069126,0.674478229730345,0.4399989434021724,0.35654836641189686,3755]
["High","O94919","endonuclease domain-containing 1 protein [OS=Homo sapiens]",21,6,10,6,500,55,5.71,10.9,"other metabolic processes","non-structural extracellular;cytosol","nucleic acid binding activity;other molecular function","ENDOD1","ENSG00000149218","","Platelet degranulation","",160.7,142.6,129.9,138.4,131.8,140.9,1.0537582096813425,0.07554387104438937,0.474381164836695,0.32387256283493915,0.6878306657465022,0.16251846581030416,5385]
["High","O94921-1","Cyclin-dependent kinase 14 [OS=Homo sapiens]",4,2,3,1,469,53,8.92,4.72,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CDK14","ENSCATG00000032271; ENSCSAG00000012501; ENSG00000058091; ENSGGOG00000003585; ENSMLEG00000038830; ENSMNEG00000032203; ENSPANG00000022338","","","Transcriptional misregulation in cancer",21.1,21.7,14.3,26.2,16.7,21.9,0.8811728395061729,-0.18250306752178191,0.5185018596346699,0.28524968165174414,0.7202388400689383,0.1425234622860465,5621]
["High","O94923","D-glucuronyl C5-epimerase [OS=Homo sapiens]",2,1,2,1,617,70.1,8.97,0,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GLCE","ENSG00000138604","","HS-GAG biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",39.3,40.9,45.6,24.2,29,24.9,1.6107554417413572,0.6877374687373099,2.7410299457892528E-3,2.5620862197614915,0.04524727656812365,1.3444075558406676,473]
["High","O94925-1","Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",27,17,56,1,669,73.4,7.77,116.85,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","GLS","ENSG00000115419; ENSGGOG00000007590; ENSPTRG00000012747","Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling","Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer",57,70.8,63.8,40.8,38.3,39.9,1.6100840336134454,0.6871359875408745,0.003942988740098933,2.404174463129638,0.05439373866200083,1.2644510896592742,566]
["High","O94925-3","Isoform 3 of Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",36,19,69,3,598,65.4,7.88,154.85,"","","","GLS","","","","",2932,3025.6,3025.7,2717.2,2686.9,2851.2,1.088185771564934,0.12192486985766282,0.01499283918726231,1.82411611721154,0.1010043903141882,0.9956597485165006,1159]
["High","O94927","HAUS augmin-like complex subunit 5 [OS=Homo sapiens]",8,4,6,4,633,71.6,8.51,17.88,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","","HAUS5","ENSG00000249115","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",217.5,191.6,199.9,208.5,209.5,215.6,0.9611742424242423,-0.05713010728591502,0.360693537476051,0.44286163883947793,0.5967991397781323,0.2241718115237918,4719]
["High","O94941-1","RING finger protein 37 [OS=Homo sapiens]",3,1,4,1,541,58.9,7.56,12.27,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","UBOX5","ENSG00000185019","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",79.4,75.3,81.3,68.9,62.4,73.4,1.1529066927210552,0.20527575722579294,0.046033355297717696,1.336927368921437,0.18546359038420007,0.7317413369775482,1938]
["High","O94952-1","Isoform 2 of F-box only protein 21 [OS=Homo sapiens]",12,6,7,6,621,71.4,6.01,18.46,"","","","FBXO21","","","","",386.8,377.9,422.2,276.4,355.3,303,1.2698191933240615,0.34462308954492454,0.035096225453208584,1.4547395887475743,0.15821670227404885,0.8007476717702667,1732]
["High","O94953","lysine-specific demethylase 4B [OS=Homo sapiens]",17,12,19,12,1096,121.8,7.09,55.62,"cell organization and biogenesis;protein metabolism;other metabolic processes","nucleus","other molecular function","KDM4B","ENSG00000127663","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Estrogen-dependent gene expression; HDMs demethylate histones","",1055.4,1021.9,1006,957.2,877,965.8,1.1011785714285713,0.13904844095009986,0.04117564853711621,1.3853595517484265,0.17368960765953717,0.7602261658426953,1851]
["High","O94964-2","Isoform 2 of Protein SOGA1 [OS=Homo sapiens]",11,17,21,14,1661,183.7,6.52,48.57,"","","","SOGA1","","","","",797.8,873.2,825.1,917.5,873.1,877.1,0.9356749259661882,-0.09592070199590186,0.09447703452777692,1.0246737469402107,0.2757669852683672,0.5594577286388225,2675]
["High","O94966-6","Isoform 6 of Ubiquitin carboxyl-terminal hydrolase 19 [OS=Homo sapiens]",18,15,26,15,1384,151.8,6.42,56.32,"","","","USP19","","","","",782.5,785.9,786.1,770.9,721.1,705.1,1.0716398889445178,0.09982018777799961,0.0573664215295573,1.2413422402071175,0.21078447967189806,0.6761613699348124,2125]
["High","O94967-1","WD repeat-containing protein 47 [OS=Homo sapiens]",3,3,4,3,919,101.9,5.94,7.7,"","cytoskeleton;other cell component","","WDR47","ENSG00000085433","","","",239.9,250.6,227.9,196.9,226.1,212.3,1.1308043444042186,0.17734933094035885,0.06048812042018894,1.2183299103483713,0.21615159919489027,0.6652415469961767,2185]
["High","O94973","AP-2 complex subunit alpha-2 [OS=Homo sapiens]",28,21,51,12,939,103.9,6.96,100.25,"transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","AP2A2","ENSG00000183020","Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission","Neutrophil degranulation; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; Potential therapeutics for SARS; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease",974.7,1021.2,1018.8,891.6,963.9,937.4,1.0794156611407497,0.11025052450229274,0.04654302478637135,1.3321453957518516,0.18626752308149025,0.7298628604877343,1951]
["High","O94979","Protein transport protein Sec31A [OS=Homo sapiens]",21,23,58,23,1220,132.9,6.89,119.61,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC31A","ENSG00000138674","Sterol regulatory element-binding proteins (SREBP) signaling","COPII-mediated vesicle transport; Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; XBP1(S) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum",2473.8,2628,2598.1,2404.2,2639.6,2585.2,1.0092934853847164,0.013345746637466238,0.7956775482177703,0.09926289633467066,0.8945500786874514,0.04839534174966965,6945]
["Low","O94983","Calmodulin-binding transcription activator 2 [OS=Homo sapiens]",1,1,1,1,1202,131.4,7.3,0,"stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CAMTA2","ENSG00000108509","","","",26.6,26.9,36.5,27.3,30.1,25.8,1.0817307692307692,0.1133414730759448,0.5510938144856476,0.2587744634978947,0.7407368744196827,0.130336035315488,5809]
["High","O94985-1","Calsyntenin-1 [OS=Homo sapiens]",1,1,2,1,981,109.7,4.91,2.37,"cell adhesion;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CLSTN1","ENSG00000171603","Splicing factor NOVA regulated synaptic proteins","","",39.2,38.9,36.7,42.7,42.5,41.3,0.9075098814229249,-0.1400147429059847,0.012375010681911817,1.907454417518163,0.09072683887734034,1.042264220634284,1065]
["High","O94986-1","Isoform 1 of Centrosomal protein of 152 kDa [OS=Homo sapiens]",5,4,4,4,1275,147.3,5.43,4.51,"","","","CEP152","","","","",37.3,41.3,40,38.7,39.1,40.5,1.0025359256128485,3.6539362062150134E-3,0.9423029714938538,0.0258094393590174,0.9736008470853527,0.011619056918157488,7557]
["High","O94992","Protein HEXIM1 [OS=Homo sapiens]",13,4,5,4,359,40.6,4.89,3.94,"stress response;developmental processes;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","HEXIM1","ENSG00000186834","Initiation of transcription and translation elongation at the HIV-1 LTR","","",229.8,252,227.8,400.8,219.9,171.1,0.8961859055316999,-0.15813005772903296,0.7165680609345633,0.14474255322963722,0.8499108946949826,0.0706266036630806,6583]
["High","O95049-1","Tight junction protein ZO-3 [OS=Homo sapiens]",3,2,2,2,919,101.3,6.76,5.46,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","TJP3","ENSG00000105289","1q21.1 copy number variation syndrome","","Tight junction",76.7,79.5,85.3,89.8,80.4,89.3,0.930635838150289,-0.1037113495221076,0.2049513692608768,0.6883491758570836,0.4316860780115797,0.36483195722801187,3707]
["High","O95057","GTP-binding protein Di-Ras1 [OS=Homo sapiens]",11,2,2,2,198,22.3,8.72,5.66,"signal transduction","plasma membrane;other membranes","other molecular function","DIRAS1","ENSG00000176490","","","",79.2,77.3,88.2,103.7,92.6,92.4,0.8475926567370972,-0.23855700615659256,0.043276956871633195,1.3637432853396256,0.1788811430670789,0.7474354386028238,1889]
["High","O95059","Ribonuclease P protein subunit p14 [OS=Homo sapiens]",16,1,2,1,124,13.7,7.75,3.51,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP14","ENSG00000163684","","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","",10.6,11.8,15.4,10.9,18,14.8,0.8649885583524026,-0.20924704527952592,0.4769249570445964,0.3215499507404711,0.6893428479459847,0.16156472593326776,5402]
["High","O95067","G2/mitotic-specific cyclin-B2 [OS=Homo sapiens]",26,8,14,8,398,45.3,8.9,33.23,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","CCNB2","ENSG00000157456","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response","Resolution of Sister Chromatid Cohesion; Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint","FoxO signaling pathway; Cell cycle; Oocyte meiosis; p53 signaling pathway; Cellular senescence; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection",735.1,736.9,753.5,657.5,732.3,703.8,1.0630015284677112,0.08814367129159695,0.12322362710393205,0.909306011838347,0.32092397612658485,0.49359783569197235,2998]
["High","O95071","E3 ubiquitin-protein ligase UBR5 [OS=Homo sapiens]",18,35,63,35,2799,309.2,5.85,149.28,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBR5","ENSG00000104517","Mesodermal commitment pathway","","Ubiquitin mediated proteolysis",2187.8,2215.8,2224.1,2257.1,2340.5,2335.7,0.9559228650137742,-0.06503388541748963,0.025102276016863236,1.600286899365524,0.13369616039540802,0.8738810650119977,1466]
["High","O95104","Splicing factor, arginine/serine-rich 15 [OS=Homo sapiens]",20,22,77,19,1147,125.8,9.55,162.91,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SCAF4","ENSG00000156304","","","",3183.6,3330.6,3395.6,3268.7,3307.3,3292.8,1.0041545071335927,0.005981270808054223,0.8406361951946113,0.0753919145508144,0.9218662095617309,0.03533210352903542,7120]
["High","O95125","Zinc finger protein 202 [OS=Homo sapiens]",3,2,4,1,648,74.7,5.97,8.5,"other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF202","ENSG00000166261","","Generic Transcription Pathway","",85.8,81.6,84.9,84.8,93.5,89.5,0.9421209858103061,-0.08601575434801023,0.14085109901927684,0.85123975999418,0.3500208087659177,0.4559061360394992,3142]
["High","O95139","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [OS=Homo sapiens]",20,2,4,2,128,15.5,9.63,9.65,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB6","ENSG00000165264","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",62,66.9,56,53.6,40.1,58.7,1.213254593175853,0.27888232191087375,0.16481851125099561,0.7829940130109722,0.3806279017591759,0.41949937911810575,3381]
["High","O95140","Mitofusin-2 [OS=Homo sapiens]",17,11,15,11,757,86.3,6.98,31.41,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion","other molecular function","MFN2","ENSG00000116688","Intracellular trafficking proteins involved in CMT neuropathy","Factors involved in megakaryocyte development and platelet production; PINK1-PRKN Mediated Mitophagy; RHOT2 GTPase cycle","Mitophagy; NOD-like receptor signaling pathway; Parkinson disease; Pathways of neurodegeneration",538,573.2,544.7,492.6,553.4,520.6,1.0570024256351336,0.07997868745641708,0.22232719495657371,0.6530074113576382,0.4534824290023322,0.34343953580380865,3828]
["High","O95149","Snurportin-1 [OS=Homo sapiens]",8,3,5,3,360,41.1,6.64,11.4,"transport","cytosol;nucleus","nucleic acid binding activity;other molecular function","SNUPN","ENSG00000169371","","snRNP Assembly","Nucleocytoplasmic transport",372.3,385.8,407.9,419.4,466.9,440.7,0.878673700075358,-0.18660058216969674,0.03561464484341893,1.4483713821719302,0.15935767732803155,0.7976270088084935,1745]
["High","O95155","Ubiquitin conjugation factor E4 B [OS=Homo sapiens]",26,26,68,24,1302,146.1,6.55,144.91,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","UBE4B","ENSG00000130939","","","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",2517.8,2571.4,2555.6,2469,2533.5,2471.8,1.0228115007425445,0.03254028779911427,0.09749946279325632,1.0109977771893315,0.28039624511592826,0.5522278064555619,2715]
["High","O95159","Zinc finger protein-like 1 [OS=Homo sapiens]",19,4,10,4,310,34.1,8.07,28.64,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","ZFPL1","ENSG00000162300","","","",794.6,711.1,689.5,750.2,733.5,744.8,0.9850572133722233,-0.0217205743272046,0.7493079087258735,0.12533968352644256,0.8677834694944557,0.061588627052760254,6742]
["High","O95163","Elongator complex protein 1 [OS=Homo sapiens]",27,25,68,25,1332,150.2,5.94,159.43,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","ELP1","ENSG00000070061","","HATs acetylate histones","",2225.2,2143.3,2298.1,2154.8,2329.8,2274.4,0.9863293386595652,-0.019858647150834824,0.6754169935432432,0.17042801668074567,0.8242663153463025,0.08393244777019854,6398]
["High","O95166","Gamma-aminobutyric acid receptor-associated protein [OS=Homo sapiens]",12,2,4,1,117,13.9,8.79,3.78,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAP","ENSG00000170296","","Macroautophagy; TBC/RABGAPs","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse",229.3,224.6,184.1,273.4,210.9,213.7,0.9140401146131805,-0.12967061244478295,0.46730043710431685,0.33040381274434916,0.6823792431102499,0.16597419218605433,5347]
["High","O95169","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [OS=Homo sapiens]",18,3,8,3,186,21.8,6.8,10.96,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;ER/Golgi","transporter activity","NDUFB8","ENSG00000166136","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Mitochondrial protein import; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",471.1,456.5,407,413.8,405.8,419.7,1.0768982490115386,0.1068819429357405,0.18408368364520736,0.7349847037115322,0.4053371127754594,0.3921836303177958,3546]
["Low","O95183","vesicle-associated membrane protein 5 [OS=Homo sapiens]",6,1,1,1,116,12.8,7.85,2.25,"transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP5","ENSG00000168899","","","SNARE interactions in vesicular transport",143.3,149.9,121.5,116.2,112.7,125.5,1.1701467268623027,0.22668944335094351,0.09908699732792334,1.0039833319852514,0.2831886072973739,0.5479242223361108,2732]
["High","O95197","Reticulon-3 [OS=Homo sapiens]",4,4,12,3,1032,112.5,4.96,24.88,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","RTN3","ENSG00000133318","Alzheimer's disease and miRNA effects; Alzheimer's disease","Synaptic adhesion-like molecules","Alzheimer disease",837.9,836.2,877.3,715.8,819.4,833.5,1.0771309156921518,0.10719360730232055,0.1976348722648091,0.7041364226230754,0.4217362893259441,0.37495902745104753,3659]
["High","O95202-1","mitochondrial proton/calcium exchanger protein [OS=Homo sapiens]",41,30,98,30,739,83.3,6.7,215.37,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;translation activity;other molecular function","LETM1","ENSG00000168924","","RHOG GTPase cycle; Mitochondrial calcium ion transport","",4133.8,4678.1,4535.6,4553.5,4254,4415.7,1.0094001451993466,0.013498199276579984,0.833334765965119,0.07918049942737167,0.9170793308887455,0.03759309456222907,7095]
["High","O95208-1","epsin-2 [OS=Homo sapiens]",7,4,5,4,641,68.4,7.52,11.18,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","EPN2","ENSG00000072134","","Cargo recognition for clathrin-mediated endocytosis","Endocytosis",246.8,263,256.9,215.4,215.3,201.5,1.212749130022145,0.2782811446012219,0.002459949478496353,2.6090738121793686,0.0431624393889877,1.364894018501665,445]
["High","O95210","Starch-binding domain-containing protein 1 [OS=Homo sapiens]",4,2,2,2,358,39,5.73,4.4,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STBD1","ENSG00000118804","Exercise-induced circadian regulation","Neutrophil degranulation; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","",166.3,178.3,168.7,159.3,159.7,147,1.1015021459227468,0.13947230566892696,0.04685386271940487,1.3292545992570932,0.186745768306847,0.7287492305931942,1959]
["High","O95218-1","Zinc finger Ran-binding domain-containing protein 2 [OS=Homo sapiens]",42,19,63,19,330,37.4,10.01,123.1,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRANB2","ENSANAG00000018241; ENSCANG00000036472; ENSCATG00000025001; ENSG00000132485; ENSGGOG00000023501; ENSMFAG00000003326; ENSMLEG00000036639; ENSMNEG00000042080; ENSNLEG00000009455; ENSPANG00000013398; ENSPPAG00000037049; ENSPTRG00000000856; ENSSBOG00000013268","","","",3025.3,3072.9,3284.3,3516.6,3316.7,3410,0.9159645817265921,-0.1266362812325089,0.04333698013977149,1.3631413549988352,0.17903446610123588,0.7470633545134439,1890]
["High","O95219","sorting nexin-4 [OS=Homo sapiens]",26,9,22,9,450,51.9,5.99,41.35,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX4","ENSG00000114520","","","Endocytosis",748.3,718,754.2,788.6,781,754.3,0.9555058307156075,-0.0656634180019242,0.08730006055266551,1.0589854550609896,0.2657461492378995,0.5755330198501892,2565]
["High","O95229","ZW10 interactor [OS=Homo sapiens]",12,3,4,3,277,31.3,5.15,8.19,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","ZWINT","ENSG00000122952","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",172.2,154.5,150.2,169.8,138.3,148.9,1.0435448577680524,0.061492617448925264,0.5932279645862852,0.22677838465097985,0.7701902140820943,0.11340200375684316,6014]
["High","O95232-1","Luc7-like protein 3 [OS=Homo sapiens]",50,23,92,23,432,51.4,9.79,185.6,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","LUC7L3","ENSCANG00000028098; ENSCATG00000034891; ENSG00000108848; ENSGGOG00000024399; ENSMLEG00000034172; ENSMMUG00000010117; ENSPPAG00000025115; ENSPTRG00000009409; ENSRROG00000039925","","","",5333.7,5517.5,5514,5538.8,5307.7,5487.4,1.0019162600481208,2.761933421496927E-3,0.9158004210643225,0.038199161129494494,0.959808011767816,0.017815629219151953,7450]
["High","O95235","kinesin-like protein KIF20A [OS=Homo sapiens]",20,15,33,15,890,100.2,6.92,63.4,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF20A","ENSG00000112984","","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Mitotic Telophase/Cytokinesis","",1043.8,1081.1,1058,971.8,978.6,949,1.0977788507967163,0.13458745052402762,2.5658108567804152E-3,2.590775361555856,0.04374203312170629,1.3591010349010901,458]
["High","O95237","lecithin retinol acyltransferase [OS=Homo sapiens]",23,4,9,4,230,25.7,7.46,16.73,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LRAT","ENSG00000121207","Vitamin A and carotenoid metabolism","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events","Retinol metabolism; Metabolic pathways; Vitamin digestion and absorption",362.1,378.2,360.9,293.6,299.7,306.4,1.2239635434033567,0.29156058700566473,5.5377252958448413E-4,3.256668591648904,0.02299923356912581,1.6382866362539483,188]
["High","O95239-1","Chromosome-associated kinesin KIF4A [OS=Homo sapiens]",48,55,162,55,1232,139.8,6.27,329.66,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","KIF4A","ENSG00000090889; ENSGGOG00000006631; ENSPTRG00000021996","Retinoblastoma gene in cancer","MHC class II antigen presentation; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",6878.8,7372,7263.4,6658,6389.5,6713.3,1.088731225456459,0.12264784059277273,0.0314433873841961,1.5024706737325062,0.15034290795823832,0.8229170538105388,1633]
["High","O95243-2","Isoform 2 of Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",9,5,6,5,574,65.3,8.84,2.68,"","","","MBD4","","","","",211,229.7,221.2,212.8,211.7,205.5,1.0506349206349206,0.0712614421938443,0.14398071533394133,0.8416956730777719,0.35519792269428563,0.4495295827725104,3165]
["High","O95248-1","Myotubularin-related protein 5 [OS=Homo sapiens]",4,6,7,6,1867,208.2,6.9,14.6,"","","","","","","","",269.9,257.2,274.9,252.5,268.1,233.1,1.0640838529919066,0.08961184400535614,0.23113936839843732,0.636126077791893,0.4623971786971557,0.3349848244145063,3903]
["High","O95249-1","Golgi SNAP receptor complex member 1 [OS=Homo sapiens]",27,8,14,8,250,28.6,9.42,28.62,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","GOSR1","ENSG00000108587","","Intra-Golgi traffic; COPI-mediated anterograde transport","SNARE interactions in vesicular transport",669.8,676.1,641.3,700,635.7,618.8,1.0167306216423637,0.023937494043828302,0.7066051650637242,0.1508231923321446,0.8433465498039678,0.0739939274624721,6542]
["High","O95251-1","Histone acetyltransferase KAT7 [OS=Homo sapiens]",17,11,25,11,611,70.6,8.85,39.46,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KAT7","ENSAMEG00000012243; ENSANAG00000032052; ENSCANG00000040077; ENSCATG00000030056; ENSCJAG00000007037; ENSDLEG00000005028; ENSECAG00000010150; ENSG00000136504; ENSGGOG00000007469; ENSMLEG00000043692; ENSMNEG00000044419; ENSPANG00000022824; ENSPCTG00005022544; ENSPPAG00000041097; ENSPPYG00000008925; ENSPTRG00000009383; ENSRFEG00010021504","Androgen receptor signaling pathway; Androgen receptor signaling pathway","HATs acetylate histones","",935.3,968.4,956,976.4,1062.2,1064.2,0.9216514116282067,-0.11770689933944511,0.056613745007664314,1.2470781155205004,0.20979597580438678,0.6782028464699653,2107]
["Low","O95259","Potassium voltage-gated channel subfamily H member 1 [OS=Homo sapiens]",1,1,1,1,989,111.4,7.58,1.63,"transport;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","KCNH1","ENSG00000143473","","Voltage gated Potassium channels","",53.9,74.5,71.5,43.8,67.7,58,1.1793510324483778,0.23799319872092167,0.3443146691673009,0.4630444742378137,0.5809008074456105,0.2358980198588903,4628]
["High","O95260-2","Isoform ATE1-2 of Arginyl-tRNA--protein transferase 1 [OS=Homo sapiens]",22,7,9,7,518,59,7.02,16.14,"","","","ATE1","","","","",203,219.8,197.6,242.3,241.5,231.2,0.8676923076923075,-0.20474455551702359,0.014143560779947401,1.8494412388840975,0.09851286580716263,1.0065070468204353,1121]
["High","O95271","Tankyrase-1 [OS=Homo sapiens]",1,2,3,2,1327,142,7.05,4.3,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","TNKS","ENSG00000173273","NAD+ biosynthetic pathways; Regulation of Wnt / B-catenin signaling by small molecule compounds","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; XAV939 stabilizes AXIN","",65.6,77.8,74.1,77.1,92.4,77.3,{"$f":"AVERAGE(T834:V834)/AVERAGE(W834:Y834)","v":0.8812803889789301},{"$f":"LOG(Z834,2)","v":-0.18232699352596518},{"$f":"TTEST(T834:V834,W834:Y834,2,2)","v":0.1915909322934628},{"$f":"-LOG10(AB834)","v":0.7176250492663586},{"$f":"AB834*7808/AF834","v":0.41427360823798326},{"$f":"-LOG10(AD834)","v":0.38271273303454983},3611]
["High","O95273-1","Cyclin-D1-binding protein 1 [OS=Homo sapiens]",9,4,10,4,360,40.2,4.82,21.8,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","","CCNDBP1","ENSG00000166946","","","",786.7,808.2,783.4,670.2,635.1,635.8,1.2252331152439337,0.2930562653180099,4.7470726310602226E-4,3.323574123447564,0.02142493821001053,1.6690804219177238,173]
["High","O95292","Vesicle-associated membrane protein-associated protein B/C [OS=Homo sapiens]",48,11,35,10,243,27.2,7.3,61.69,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAPB","ENSG00000124164","Ciliary landscape","RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle; Sphingolipid de novo biosynthesis","Cholesterol metabolism; Amyotrophic lateral sclerosis; Pathways of neurodegeneration",2093.9,1953.5,1919,2107.3,2035.8,1891.1,0.9887640449438201,-0.0163018123291007,0.7990996605602307,0.09739905381206967,0.8963324450013334,0.04753088291422271,6961]
["Medium","O95294-1","RasGAP-activating-like protein 1 [OS=Homo sapiens]",1,1,1,1,804,90,6.51,0,"signal transduction;other biological processes","cytosol","enzyme regulator activity;other molecular function","RASAL1","ENSG00000111344","Ras signaling","Regulation of RAS by GAPs","Ras signaling pathway",16.4,15,10.1,15.3,15.1,16.3,0.8886509635974303,-0.17031121347537492,0.4233394583723365,0.3733112501777285,0.6455926740178132,0.19004140649492385,5120]
["High","O95295","SNARE-associated protein Snapin [OS=Homo sapiens]",14,2,4,2,136,14.9,9.31,7.34,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SNAPIN","ENSG00000143553","","Golgi Associated Vesicle Biogenesis","",101.2,102,82.7,86.7,72.1,77.8,1.2083685545224006,0.2730605462913095,0.09670487201964614,1.0145516454832078,0.2795526252237679,0.5535364250120234,2701]
["High","O95297-1","Myelin protein zero-like protein 1 [OS=Homo sapiens]",13,3,6,3,269,29.1,8.72,11.85,"cell-cell signaling;signal transduction","plasma membrane;other membranes","other molecular function","MPZL1","ENSG00000197965","","","Cell adhesion molecules",184.5,181,166,224.5,192.4,215.4,0.8405820022141389,-0.2505395277555286,0.03899654399250407,1.4089738799348213,0.1672994590623471,0.7765054632612606,1820]
["High","O95298-1","NADH dehydrogenase [ubiquinone] 1 subunit C2 [OS=Homo sapiens]",24,4,14,4,119,14.2,8.98,25.51,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","NDUFC2","ENSG00000151366; ENSGGOG00000041901","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Neutrophil degranulation; Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",1104.2,1003.4,903.1,826.7,979.9,968.8,1.0847805721697774,0.11740324593451354,0.3613617430982637,0.4420578275381734,0.5972719073055129,0.22382791182101514,4724]
["High","O95299","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [OS=Homo sapiens]",22,7,18,7,355,40.7,8.48,37.43,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity","NDUFA10","ENSG00000130414","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",860.8,879.3,874.4,883.9,964.7,927.4,0.9418227665706052,-0.08647249773141974,0.08827347632951373,1.0541697699687205,0.2677697370554946,0.572238507878453,2574]
["High","O95302","Peptidyl-prolyl cis-trans isomerase FKBP9 [OS=Homo sapiens]",7,5,8,4,570,63,5.08,9.64,"protein metabolism;other metabolic processes;other biological processes","ER/Golgi","other molecular function","FKBP9","ENSG00000122642","","Association of TriC/CCT with target proteins during biosynthesis","",269.5,262.8,265.7,293.1,258,268.5,0.9736456808199122,-0.03853123790153843,0.5335513258834588,0.27282379652856126,0.7284435657454181,0.13760408841659813,5719]
["High","O95336","6-phosphogluconolactonase [OS=Homo sapiens]",52,10,57,10,258,27.5,6.05,133.7,"other metabolic processes","cytosol;other cell component","other molecular function","PGLS","ENSG00000130313","Pentose phosphate metabolism","Pentose phosphate pathway","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism",2201.4,2244.6,2260.4,2114.8,2231.7,2194.6,1.025270978887343,0.03600526410119971,0.22795720763475705,0.6421466715624112,0.45968230299901425,0.33754221554013186,3872]
["High","O95340","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [OS=Homo sapiens]",16,9,11,8,614,69.5,8.03,20.58,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS2","ENSG00000198682","RANKL/RANK signaling pathway; Proteoglycan biosynthesis; Sulfation biotransformation reaction","Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Defective PAPSS2 causes SEMD-PA","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways",520.1,519.7,513.9,503.3,510.2,512.7,1.0180186083082166,0.02576393260086023,0.056645420813935865,1.2468351925193915,0.20971429384315374,0.6783719676002424,2109]
["High","O95347-1","structural maintenance of chromosomes protein 2 [OS=Homo sapiens]",51,64,194,64,1197,135.6,8.43,396.49,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC2; SMC2L1","ENSG00000136824","Retinoblastoma gene in cancer","Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes","",8329.4,8704.2,8650,9143.2,9029.4,9191.8,0.9385771294090132,-0.0914527886765226,0.011420281595163244,1.9423231873583169,0.08733551292363821,1.0588091247865918,1021]
["High","O95352","Ubiquitin-like modifier-activating enzyme ATG7 [OS=Homo sapiens]",6,4,5,4,703,77.9,6.24,8.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","other molecular function","ATG7","ENSG00000197548","Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy","Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Macroautophagy","Autophagy; Autophagy; Ferroptosis; Neutrophil extracellular trap formation",354.7,319.8,368,342.9,338.6,327.7,1.0329964328180736,0.04683527224308776,0.5021831726906865,0.29913784385331993,0.7082814689972687,0.14979412064338596,5536]
["High","O95359-3","Isoform 3 of Transforming acidic coiled-coil-containing protein 2 [OS=Homo sapiens]",8,15,28,12,2871,300.9,4.78,64.6,"","","","TACC2","","","","",471.1,529.6,509.9,559.7,498.1,494.1,0.9733874605322506,-0.03891390537929055,0.6407538931179333,0.19330874643205326,0.8029219061891868,0.09532669302817944,6231]
["High","O95363","phenylalanine--tRNA ligase, mitochondrial [OS=Homo sapiens]",8,4,5,4,451,52.3,7.46,10.62,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","FARS2","ENSG00000145982","","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",205.3,230.4,206.9,196.3,228.2,197.8,1.032620922384702,0.04631073458403818,0.6348307299808096,0.19734205870030902,0.7989616924065379,0.09747404318324095,6204]
["High","O95365","Zinc finger and BTB domain-containing protein 7A [OS=Homo sapiens]",4,1,2,1,584,61.4,5.19,7.63,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB7A","ENSG00000178951","IL-18 signaling pathway","","",17,13.8,15.1,13.4,13.8,14.8,1.0928571428571427,0.12810482574768517,0.2707566142406075,0.567420925309802,0.5063635075426739,0.29553760047078753,4175]
["High","O95372","acyl-protein thioesterase 2 [OS=Homo sapiens]",29,5,19,5,231,24.7,7.23,45.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;other cell component","other molecular function","LYPLA2","ENSG00000011009","","L1CAM interactions","Glycerophospholipid metabolism",763.2,728.9,682.9,679,649.8,646.8,1.100931362624013,0.1387245271323711,0.059179963490602394,1.2278253071009486,0.21422213951535626,0.6691356475448583,2157]
["High","O95373","Importin-7 [OS=Homo sapiens]",43,36,155,35,1038,119.4,4.82,339.8,"stress response;transport;signal transduction;other biological processes","cytosol;nucleus","transporter activity;enzyme regulator activity;other molecular function","IPO7","ENSG00000205339","","","Nucleocytoplasmic transport",5320.8,5411.4,5685.6,4995.4,5451,5335,1.0403259533374736,0.05703562219967095,0.292735789054176,0.5335241786984888,0.530566629743502,0.27526006866579733,4308]
["High","O95376","E3 ubiquitin-protein ligase ARIH2 [OS=Homo sapiens]",31,11,24,11,493,57.8,5.63,55.14,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","ARIH2","ENSG00000177479","Modulators of TCR signaling and T cell activation","Antigen processing: Ubiquitination & Proteasome degradation","",527.2,529.5,500.3,561.3,489.7,563.2,0.9645644901499194,-0.05205039574297671,0.5031236786448733,0.298325242875373,0.7089676381265423,0.14937358837664141,5541]
["High","O95379","Tumor necrosis factor alpha-induced protein 8 [OS=Homo sapiens]",19,3,6,3,198,23,7.93,13.26,"other biological processes","nucleus;other cell component","enzyme regulator activity","TNFAIP8","ENSG00000145779","","PI Metabolism","",94.6,90.7,90.3,86.2,85.2,89.5,1.0563434266002303,0.07907894388683968,0.06044404164417587,1.218646503878372,0.21609298404657745,0.6653593332524362,2184]
["High","O95391","Pre-mRNA-splicing factor SLU7 [OS=Homo sapiens]",11,4,5,4,586,68.3,7.14,8.18,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLU7","ENSG00000164609","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","Spliceosome",78,81.8,73.9,69.6,76,70.5,1.081443776029616,0.11295866192331827,0.12527896640586794,0.9021218383487101,0.324868206475263,0.488292789202834,3011]
["High","O95394","phosphoacetylglucosamine mutase [OS=Homo sapiens]",32,16,28,16,542,59.8,6.25,48.67,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PGM3","ENSG00000013375","Glucuronidation","Synthesis of UDP-N-acetyl-glucosamine","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",1657.4,1772.9,1607.5,1649.7,1996,1772.8,0.9297407031466273,-0.10509967806926063,0.32264858272023883,0.49127023825290905,0.5603292112721585,0.25155673615527835,4496]
["High","O95396","Adenylyltransferase and sulfurtransferase MOCS3 [OS=Homo sapiens]",15,7,12,7,460,49.6,6.21,29.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","MOCS3","ENSG00000124217","","Molybdenum cofactor biosynthesis","Sulfur relay system",373.6,350.5,349.9,371.7,343.1,355.2,1.0037383177570094,0.005383196696903374,0.9123993766489349,0.039815020105187754,0.9585595173405387,0.01838091643213771,7432]
["High","O95400","CD2 antigen cytoplasmic tail-binding protein 2 [OS=Homo sapiens]",40,7,25,7,341,37.6,4.61,49.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","CD2BP2","ENSG00000169217","mRNA processing; Ciliary landscape","mRNA Splicing - Major Pathway","",716.9,717.4,708.8,733.5,641,631.4,1.068398225235555,0.0954494845618959,0.2341474217297157,0.6305106200075564,0.4657893169084383,0.3318104764301923,3925]
["High","O95405-1","Zinc finger FYVE domain-containing protein 9 [OS=Homo sapiens]",2,1,1,1,1425,156.3,5.01,0,"transport;signal transduction","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ZFYVE9","ENSG00000157077","TGF-beta signaling pathway; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling","","Endocytosis; TGF-beta signaling pathway",20.2,19.4,25.7,29.5,27.6,29,0.7584204413472706,-0.39893024585041326,0.028164502711263435,1.5502979125152925,0.14169358065047996,0.8486498247788267,1552]
["High","O95409","Zinc finger protein ZIC 2 [OS=Homo sapiens]",6,3,6,2,532,55,8.41,13.67,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZIC2","ENSG00000043355","Mesodermal commitment pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Ciliopathies","","",133.4,146.1,156.6,156.5,165.6,135.8,0.9523913518235422,-0.07037357459194127,0.5476786116895227,0.26147421909785684,0.7388173116917404,0.13146293688622132,5788]
["High","O95425","Supervillin [OS=Homo sapiens]",11,16,21,16,2214,247.6,6.98,37.41,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SVIL","ENSG00000197321","","","",511.9,546.3,508.3,607.3,565.4,576.8,0.8953986853386682,-0.15939789486879571,0.02481355590825898,1.605310994668705,0.1329747731857832,0.8762307417800596,1457]
["High","O95427","GPI ethanolamine phosphate transferase 1 [OS=Homo sapiens]",2,2,2,2,931,105.7,8.65,4.32,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","PIGN","ENSG00000197563","","Synthesis of glycosylphosphatidylinositol (GPI)","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways",141.2,123,103.5,135.7,122.3,133.3,0.9396882187579861,-0.08974593369749799,0.5362293574716076,0.27064941295869144,0.7300573362054599,0.1366430305373425,5735]
["High","O95433","activator of 90 kDa heat shock protein ATPase homolog 1 [OS=Homo sapiens]",71,19,96,19,338,38.3,5.53,234.42,"other biological processes","cytosol;ER/Golgi","other molecular function","AHSA1","ENSG00000100591","T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection","","",4605.7,4463.2,4456.8,4538.1,4497.1,4653.8,0.9880707137117394,-0.017313799362261538,0.4655383962497133,0.33204449386267476,0.6809523787781494,0.16688325865552822,5338]
["Medium","O95452","Gap junction beta-6 protein [OS=Homo sapiens]",2,1,1,1,261,30.4,8.51,1.99,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","transporter activity;cytoskeletal activity","GJB6","ENSG00000121742","Calcium regulation in cardiac cells","Gap junction assembly","",57.8,62.1,68.1,77.9,83.8,76.6,0.7889215274863618,-0.3420462896252711,0.01075058878270632,1.968567749880645,0.0846175375154949,1.0725396173761885,992]
["High","O95453","poly(A)-specific ribonuclease PARN [OS=Homo sapiens]",16,9,20,9,639,73.4,6.2,38.49,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARN","ENSG00000140694; ENSG00000274829","Lung fibrosis","Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA","RNA degradation",849.4,879.8,885,892.4,937.2,943.7,0.9426315220134857,-0.08523416836950272,0.053604413241693766,1.2707994534487568,0.2026843867269467,0.6931797047825412,2065]
["High","O95456","Proteasome assembly chaperone 1 [OS=Homo sapiens]",46,10,26,10,288,32.8,7.17,55.54,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","PSMG1","ENSG00000183527","","","",1058.7,1082.9,1098,1062.8,1329.7,1216.8,0.8975701659601585,-0.15590337141017632,0.19015134752640525,0.7209005925705244,0.4129907431115917,0.3840596826307905,3595]
["Medium","O95460","matrilin-4 [OS=Homo sapiens]",2,1,1,1,622,68.4,6.1,0,"","non-structural extracellular;extracellular matrix","other molecular function","MATN4","ENSG00000124159","","ECM proteoglycans","",70,75,83.1,77.7,72.4,71.8,1.02794051374493,0.03975677911512581,0.6523842344518698,0.18549654268585072,0.8095702642403367,0.0917454519784646,6292]
["High","O95470","sphingosine-1-phosphate lyase 1 [OS=Homo sapiens]",13,7,15,7,568,63.5,9.16,27.09,"other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","SGPL1","ENSG00000166224","Sphingolipid pathway; Kennedy pathway from sphingolipids; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway","Sphingolipid de novo biosynthesis","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway",817.7,746.2,757.2,736.2,740.7,747.2,1.0436131468908774,0.061587023697672584,0.22332831646939616,0.6510562079328502,0.45469295827719564,0.3422817715592146,3835]
["High","O95478","Ribosome biogenesis protein NSA2 homolog [OS=Homo sapiens]",24,5,21,5,260,30,10.27,29.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","NSA2","ENSG00000164346","","","",930.4,913.1,888.4,1005.1,1046.5,1039.8,0.883709646115029,-0.17835566296131444,2.4811355817880233E-3,2.6053495030339016,0.04333938841745165,1.3631172215072027,447]
["High","O95479","GDH/6PGL endoplasmic bifunctional protein [OS=Homo sapiens]",11,8,14,8,791,88.8,7.3,27.85,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","H6PD","ENSG00000049239","Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism","","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism",471.5,469.4,430.9,419.4,442.5,430.9,1.0611076732673266,0.08557105757896154,0.14952314716289897,0.8252915705036464,0.36245784944052006,0.4407424906647024,3221]
["High","O95486-1","Protein transport protein Sec24A [OS=Homo sapiens]",8,9,15,9,1093,119.7,7.66,32.26,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi","other molecular function","SEC24A","ENSG00000113615","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",544.3,530,567.6,497.4,547,565.2,1.0200670974155068,0.028664052123117147,0.6645111179865675,0.17749774844612043,0.8163157346191187,0.08814183232282702,6356]
["High","O95487-1","Protein transport protein Sec24B [OS=Homo sapiens]",8,9,13,9,1268,137.3,6.67,27.89,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SEC24B","ENSG00000138802","Sterol regulatory element-binding proteins (SREBP) signaling","COPII-mediated vesicle transport; MHC class II antigen presentation; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection",434.2,422.5,442.3,429.1,424.3,434.8,1.0083837913367488,0.01204483375531387,0.6091446596076995,0.21527955891233647,0.7813703798614945,0.10714305600670955,6087]
["High","O95490-1","Adhesion G protein-coupled receptor L2 [OS=Homo sapiens]",16,16,33,16,1459,163.2,6.43,61.6,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ADGRL2","ENSG00000117114","GPCRs, other; GPCRs, class B secretin-like","","",1055.3,1005.8,962.7,1017.3,929.9,936.5,1.0485834171377053,0.06844163559176854,0.2950658903885276,0.5300809920325251,0.532564602901901,0.27362770247696233,4326]
["High","O95502","neuronal pentraxin receptor [OS=Homo sapiens]",2,1,2,1,500,52.8,6.21,4.73,"other biological processes","other membranes;other cell component","other molecular function","NPTXR","ENSG00000221890","","","",57.8,49.1,52.3,56.2,38.7,53.2,1.0749493585415257,0.10426869525480076,0.5690132518453199,0.24487761912992004,0.7546892254812737,0.1222318502834536,5887]
["High","O95528","Solute carrier family 2, facilitated glucose transporter member 10 [OS=Homo sapiens]",4,2,2,2,541,56.9,8.59,2.24,"transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC2A10","ENSG00000197496","Nuclear receptors meta-pathway; NRF2 pathway","Cellular hexose transport; Defective SLC2A10 causes arterial tortuosity syndrome (ATS)","",21.7,17.7,21.1,19.9,20.8,21,0.980551053484603,-0.028335346987460864,0.7720813609080996,0.112336931877206,0.8810890479348791,0.0549801970676143,6842]
["High","O95544","NAD kinase [OS=Homo sapiens]",4,1,2,1,446,49.2,6.47,2.77,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NADK","ENSG00000008130","NAD+ metabolism","Nicotinate metabolism","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors",32.8,45.5,41.6,28.8,45.5,43.1,1.0212947189097104,0.030399250304171378,0.9030650223391093,0.04428097856088295,0.9540159240189103,0.020444376180784214,7391]
["High","O95551-1","Tyrosyl-DNA phosphodiesterase 2 [OS=Homo sapiens]",23,6,14,6,362,40.9,5.1,33.83,"DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TDP2","ENSG00000111802","Oxidative damage response","Nonhomologous End-Joining (NHEJ)","",563,468.1,459,513.2,530.2,495.5,0.968289037624277,-0.046490333643656435,0.663900769704268,0.17789682784634286,0.8160795355558761,0.0882675126067473,6352]
["High","O95562","Vesicle transport protein SFT2B [OS=Homo sapiens]",17,2,3,2,160,17.8,9.13,9.05,"transport","other membranes","","SFT2D2","ENSG00000213064","TYROBP causal network in microglia","","",76.8,83.7,87.1,109.4,96.1,94.4,0.8256085361787263,-0.2764702076544755,0.036295800465644006,1.4401436212477692,0.16038348049561313,0.7948403660958978,1767]
["Medium","O95563","Mitochondrial pyruvate carrier 2 [OS=Homo sapiens]",8,1,1,1,127,14.3,10.43,2,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MPC2","ENSG00000143158","Glycolysis and gluconeogenesis","Pyruvate metabolism","Diabetic cardiomyopathy",35.1,29.5,31,22.6,26.8,25.9,1.2695883134130141,0.3443607533088199,0.03244856026188402,1.4888045680220259,0.15244185230131796,0.8168957828114826,1662]
["Medium","O95568","histidine protein methyltransferase 1 homolog [OS=Homo sapiens]",3,1,1,1,372,42.1,6.76,2.2,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","METTL18","ENSG00000171806","","","",51.2,39.4,44.5,49.5,51.7,51.6,0.8841623036649213,-0.1776168687100644,0.16630560904011069,0.7790931029507216,0.38202830108419655,0.417904462875146,3399]
["High","O95571","Persulfide dioxygenase ETHE1, mitochondrial [OS=Homo sapiens]",12,2,4,2,254,27.9,6.83,12.38,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","ETHE1","ENSG00000105755","","Sulfide oxidation to sulfate","Sulfur metabolism; Metabolic pathways",126.2,113.2,115.3,101.4,81.5,101,1.2493835857696374,0.32121648121079727,0.03755213382436215,1.4253653800495285,0.1634376036235338,0.7866480140989666,1794]
["High","O95573","long-chain-fatty-acid--CoA ligase 3 [OS=Homo sapiens]",34,19,75,16,720,80.4,8.38,200.86,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL3","ENSG00000123983","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Ciliary landscape; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway",4105,3985.5,4063.4,3942.2,4325.7,4345,0.9636086863449325,-0.05348069623597425,0.3227887526776982,0.49108160633878933,0.5603233839278496,0.25156125277976726,4498]
["High","O95602","DNA-directed RNA polymerase I subunit RPA1 [OS=Homo sapiens]",31,42,105,41,1720,194.7,7.03,243.35,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR1A","ENSG00000068654","Pyrimidine metabolism; Eukaryotic transcription initiation","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","RNA polymerase",3707.2,3803.4,3790.4,3870.1,3882.4,3900.6,0.9697848641134118,-0.04426335779461807,0.020180372429441984,1.6950708231060931,0.11882982498422551,0.925074542516212,1326]
["High","O95613","Pericentrin [OS=Homo sapiens]",12,29,38,29,3336,377.8,5.55,73.09,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton","other molecular function","PCNT","ENSG00000160299","","Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy","",1038.1,1154.8,1124,1280.9,1223.6,1264.8,0.879977714695036,-0.1844611067124969,0.017837086386370226,1.7486760843580087,0.11123959305493508,0.9537406085737843,1252]
["High","O95619","YEATS domain-containing protein 4 [OS=Homo sapiens]",30,7,12,7,227,26.5,8.41,24.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus","cytoskeletal activity;other molecular function","YEATS4","ENSG00000127337","","HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors","",699.8,638.7,636.3,731.2,729.4,697.6,0.9150217774070986,-0.1281220151154392,0.05974528579213803,1.223696357078272,0.21517121377537535,0.667215830285986,2168]
["High","O95625","Zinc finger and BTB domain-containing protein 11 [OS=Homo sapiens]",6,6,6,6,1053,119.3,8.66,10.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB11","ENSG00000066422","","","",263.8,258.5,263.3,236.1,244.6,245.5,1.0817956485816576,0.11342799951448534,0.004510865618494523,2.3457401106135722,0.05736292955896618,1.2413686770961048,614]
["High","O95628-1","CCR4-NOT transcription complex subunit 4 [OS=Homo sapiens]",19,8,15,8,575,63.5,7.03,22.75,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CNOT4","ENSG00000080802","","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","RNA degradation",323.6,303.6,312.7,279.2,289.4,273.7,1.1158732043215007,0.15817310432738035,0.011657308787099514,1.9334016994753245,0.08845506998024588,1.053277269579122,1029]
["High","O95630","STAM-binding protein [OS=Homo sapiens]",17,8,15,8,424,48,6.29,30.37,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","STAMBP","ENSG00000124356","EGF/EGFR signaling pathway","Metalloprotease DUBs","Endocytosis",935.3,919.8,932.4,836.1,903.9,829,1.0850525496302061,0.11776491479421233,0.040250051793969906,1.3952335564434206,0.17089309646944917,0.7672754810228628,1839]
["High","O95639","Cleavage and polyadenylation specificity factor subunit 4 [OS=Homo sapiens]",13,3,11,3,269,30.2,8.31,18.7,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CPSF4","ENSG00000160917","mRNA processing","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA surveillance pathway; Influenza A",543,518.8,511.9,541.9,515.5,518.7,0.9984772539813462,-0.002198532458064249,0.9523226980139492,0.02121586441005163,0.9774859505840562,0.009889476006435447,7607]
["High","O95671-1","N-acetylserotonin O-methyltransferase-like protein [OS=Homo sapiens]",40,20,61,20,621,68.8,6.07,143.5,"other metabolic processes","cytosol","other molecular function","ASMTL","ENSG00000169093","","","Pyrimidine metabolism; Metabolic pathways",2533.3,2534.6,2513.8,2394.9,2546.6,2453.5,1.0252467883705205,0.03597122436819633,0.23605896767238746,0.626979496454264,0.4680417520533269,0.32971540359772794,3938]
["High","O95674-1","phosphatidate cytidylyltransferase 2 [OS=Homo sapiens]",28,8,30,8,445,51.4,7.09,76.88,"cell organization and biogenesis;other metabolic processes","other membranes;mitochondrion;ER/Golgi","other molecular function","CDS2","ENSG00000101290","","Synthesis of PG","Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system",959.3,870,888.5,844.7,902.7,884.3,1.0327164950412282,0.04644425484716799,0.42241630093644256,0.37425933083847507,0.6448145606474571,0.19056516422801867,5115]
["High","O95684","FGFR1 oncogene partner [OS=Homo sapiens]",29,6,8,6,399,43,4.81,15.09,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","CEP43","ENSG00000213066","Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",127.1,141.3,138.7,113.4,148.7,145.5,0.998773307163886,-1.7708300258037258E-3,0.989658680411521,4.5145617385068575E-3,0.995395462663037,2.0043432432883504E-3,7763]
["High","O95696-2","Isoform 2 of Bromodomain-containing protein 1 [OS=Homo sapiens]",10,9,13,9,1189,133.2,8.59,26.54,"","","","BRD1","","","","",506,537.9,533,537.7,530.2,550.8,0.9741768085500709,-0.03774445638982315,0.29601741608308396,0.5286827366225774,0.5332957971335301,0.2730318389477412,4334]
["High","O95707","Ribonuclease P protein subunit p29 [OS=Homo sapiens]",6,1,2,1,220,25.4,10.07,3.56,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP4","ENSG00000105171","","tRNA processing in the nucleus","Ribosome biogenesis in eukaryotes",49.4,45.2,52.8,42.4,42.4,38.1,1.199349064279902,0.2622516087224077,0.03579365169031546,1.4461939923601166,0.1597010470845618,0.7966922363877756,1750]
["High","O95714","E3 ubiquitin-protein ligase HERC2 [OS=Homo sapiens]",3,14,19,14,4834,526.9,6.28,37.23,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HERC2","ENSG00000128731","Prader-Willi and Angelman syndrome","SUMOylation of DNA damage response and repair proteins; Antigen processing: Ubiquitination & Proteasome degradation; Nonhomologous End-Joining (NHEJ); Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint","Ubiquitin mediated proteolysis",392.2,382.8,395.3,380.7,406.5,386.1,0.9974431091792377,-3.693537708383589E-3,0.914116035808179,0.03899867241427743,0.9594593369525826,0.017973426464023976,7439]
["High","O95716","ras-related protein Rab-3D [OS=Homo sapiens]",41,8,19,5,219,24.3,4.93,39.34,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3D","ENSG00000105514","","Neutrophil degranulation; RAB geranylgeranylation","Pancreatic secretion",547.2,596.6,631.3,551.1,666.8,576.6,0.9891891891891893,-0.015681622232269512,0.8870769537610876,0.05203870356833563,0.9469916400008985,0.02365385491172581,7314]
["High","O95747","Serine/threonine-protein kinase OSR1 [OS=Homo sapiens]",37,16,61,14,527,58,6.43,137.72,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol","kinase activity;other molecular function","OXSR1","ENSG00000172939","","","",2191.2,2248.8,2215.6,2098.1,2092.5,2054.3,1.0657656647824623,0.09189026040425498,3.1916708452750376E-3,2.4959819034903745,0.04925013035554841,1.3075926156715383,506]
["High","O95749","geranylgeranyl pyrophosphate synthase [OS=Homo sapiens]",17,5,9,5,300,34.8,6.14,16.5,"other metabolic processes","cytosol","other molecular function","GGPS1","ENSG00000152904","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Terpenoid backbone biosynthesis; Metabolic pathways",551.6,544.5,492.1,506.3,467.2,486.3,1.0879572544184135,0.12162187455696939,0.12229990619950412,0.9125738760549115,0.3193704573932201,0.4957052597207057,2990]
["High","O95754-1","Semaphorin-4F [OS=Homo sapiens]",2,1,2,1,770,83.5,6.95,5.43,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","SEMA4F","ENSG00000135622","","RND3 GTPase cycle","Axon guidance",34,31.4,25.7,22.2,23.3,22.8,{"$f":"AVERAGE(T898:V898)/AVERAGE(W898:Y898)","v":1.333821376281113},{"$f":"LOG(Z898,2)","v":0.41556547551196066},{"$f":"TTEST(T898:V898,W898:Y898,2,2)","v":0.03711500163028552},{"$f":"-LOG10(AB898)","v":1.4304505160348047},{"$f":"AB898*7808/AF898","v":0.16234954214524894},{"$f":"-LOG10(AD898)","v":0.7895489318243812},1785]
["High","O95757","Heat shock 70 kDa protein 4L [OS=Homo sapiens]",31,19,58,14,839,94.5,5.88,120.14,"stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","HSPA4L","ENSG00000164070","","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",918.3,955.1,955,944.1,954.7,936.1,0.997707150164027,-0.003311681134136181,0.879227940092256,0.05589851936176334,0.9423489027097234,0.025788270809136905,7285]
["High","O95758-1","Isoform 1 of Polypyrimidine tract-binding protein 3 [OS=Homo sapiens]",9,6,44,2,521,56.5,9.22,71.01,"","","","PTBP3","","","","",165,163.7,156.9,168.6,175.9,151.6,0.9788349123160653,-0.03086253563699608,0.6700274119380661,0.17390742922467597,0.8203816892602197,0.08598404155329561,6377]
["High","O95772-1","STARD3 N-terminal-like protein [OS=Homo sapiens]",12,3,5,3,234,26.6,4.81,9.62,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STARD3NL","ENSCANG00000042172; ENSCATG00000036966; ENSCSAG00000015104; ENSG00000010270; ENSGGOG00000013471; ENSMFAG00000043802; ENSMLEG00000030425; ENSMMUG00000023659; ENSMNEG00000034363; ENSPANG00000016262; ENSPPAG00000039214; ENSPTRG00000019094; ENSRBIG00000036179; ENSRROG00000026971","","Pregnenolone biosynthesis","",388,383.8,385.6,382.6,378.2,401.1,0.9961270333075135,-5.598357979243419E-3,0.8434521135908704,0.07393956914313582,0.9233979392761519,0.03461109898781744,7132]
["High","O95777","U6 snRNA-associated Sm-like protein LSm8 [OS=Homo sapiens]",52,3,17,3,96,10.4,4.48,40.09,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","LSM8","ENSG00000128534","","mRNA Splicing - Major Pathway","RNA degradation; Spliceosome",311.7,293.8,309.1,297.2,326,295.6,0.9954288202002611,-0.006609937570960396,0.907753676717856,0.042031983367928655,0.9565102169788151,0.01931038668862141,7410]
["High","O95782-2","Isoform B of AP-2 complex subunit alpha-1 [OS=Homo sapiens]",40,31,81,22,955,105.3,7.66,182.32,"","","","AP2A1","","","","",3262.6,3365.1,3338.9,2880.4,3086.6,2867.6,1.128132569669255,0.17393661238775923,0.008165956585003537,2.087992933370102,0.07626769021017657,1.117659406150483,836]
["High","O95785-3","Isoform 3 of Protein Wiz [OS=Homo sapiens]",19,12,21,3,965,102.9,9.52,51.56,"","","","WIZ","","","","",455.5,514.3,502.7,482.2,513.4,505.1,0.9812087692410209,-0.02736796730656478,0.6667577524576049,0.1760319260243096,0.8180459665601789,0.08722229234021817,6364]
["High","O95785-4","Isoform 4 of Protein Wiz [OS=Homo sapiens]",19,10,20,1,835,89.3,9.48,51.01,"","","","WIZ","","","","",16.6,11.3,12.9,19.5,11.7,18.6,0.8192771084337351,-0.28757659009658504,0.36247354139401755,0.4407236890818175,0.597970296049966,0.22332038889117614,4733]
["High","O95786","Probable ATP-dependent RNA helicase DDX58 [OS=Homo sapiens]",1,1,1,1,925,106.5,6.4,3.27,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","DDX58","ENSG00000107201","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Pathways of nucleic acid metabolism and innate immune sensing; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation","ISG15 antiviral mechanism; Ub-specific processing proteases; OAS antiviral response; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation","NF-kappa B signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease",42.4,39,41.4,44.6,47.3,56.9,0.8252688172043011,-0.2770639657378519,0.08846197783978152,1.0532433548680573,0.2675101173404392,0.5726597881398233,2582]
["High","O95789","Zinc finger MYM-type protein 6 [OS=Homo sapiens]",3,3,4,3,1325,148,8.22,0,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZMYM6","ENSG00000163867","","","",32.9,21.6,35.9,23.5,27.7,28.9,1.1285892634207242,0.17452053000647771,0.5013881790244916,0.29982590939844816,0.7077994760121552,0.15008976320897838,5531]
["High","O95793","double-stranded RNA-binding protein Staufen homolog 1 [OS=Homo sapiens]",36,18,38,18,577,63.1,9.44,75.33,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","STAU1","ENSG00000124214","","","",2139.2,2148.4,2065.7,2063.9,1908.4,1873.9,1.086740104683384,0.12000695921001324,0.05758540080355282,1.2396876060576936,0.21089437592595706,0.6759350017535928,2132]
["High","O95801","Tetratricopeptide repeat protein 4 [OS=Homo sapiens]",51,15,50,15,387,44.7,5.6,111.91,"stress response","nucleus;other cell component","other molecular function","TTC4","ENSG00000243725","","","",2334.9,2441.3,2361.6,2433.2,2322.8,2305.4,1.0108193842580793,0.015525235901910368,0.6450905718631753,0.1903793053664046,0.8052545459804432,0.094066814737208,6255]
["Medium","O95807","transmembrane protein 50A [OS=Homo sapiens]",6,1,1,1,157,17.4,5.87,2.4,"transport","other membranes;ER/Golgi;other cell component","","TMEM50A","ENSG00000183726","","","",51.8,63.9,53.7,54.7,59.5,62.8,0.9570621468926552,-0.06331548563816138,0.5981955081158487,0.22315685243446426,0.7744504273534317,0.11100637624678163,6031]
["High","O95816","BAG family molecular chaperone regulator 2 [OS=Homo sapiens]",37,8,19,8,211,23.8,6.7,30.16,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","BAG2","ENSG00000112208","Malignant pleural mesothelioma","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",828.5,789.8,689.1,868.7,766.6,726.4,0.9770080873946732,-0.03355759042563853,0.775524659374962,0.11040438835945768,0.8828249803761049,0.05412538655930912,6859]
["High","O95817","BAG family molecular chaperone regulator 3 [OS=Homo sapiens]",2,1,1,1,575,61.6,6.95,2.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BAG3","ENSG00000151929","","Regulation of HSF1-mediated heat shock response","",16.6,18.8,18.1,34.1,14.5,13.4,0.8629032258064516,-0.21272932398572825,0.6964570067954242,0.1571056879805911,0.8371207372319385,0.0772118995550746,6496]
["High","O95819","Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",18,19,46,1,1239,142,7.46,103.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","cytoskeletal activity;kinase activity;other molecular function","MAP4K4","ENSG00000071054","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma","Oxidative Stress Induced Senescence","MAPK signaling pathway",40,37.3,36.6,47.6,34.1,38.5,0.9475873544093177,-0.07766914900307369,0.6361356244776335,0.19645028264884773,0.7994442227460747,0.09721183160332737,6213]
["High","O95819-3","Isoform 3 of Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",17,19,47,1,1320,150.9,7.42,106.24,"","","","MAP4K4","","","","",2161.2,2206.2,2327,2326.2,2372.1,2328.5,0.9526953947742928,-0.06991307980158841,0.09876024926674666,1.0054178225975783,0.28246154808599194,0.5490406649796988,2730]
["High","O95822","Malonyl-CoA decarboxylase, mitochondrial [OS=Homo sapiens]",14,5,7,5,493,55,8.95,19.9,"other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","MLYCD","ENSG00000103150","","","beta-Alanine metabolism; Propanoate metabolism; Metabolic pathways; Peroxisome; AMPK signaling pathway; Alcoholic liver disease",291.6,276.9,298.4,268.5,294.8,300.6,1.0034726241463132,0.00500125890572877,0.9362048296850505,0.02862912276833267,0.9705107952975138,0.012999629454324473,7532]
["High","O95825-1","Quinone oxidoreductase-like protein 1 [OS=Homo sapiens]",22,6,16,6,349,38.7,5.78,20.08,"other metabolic processes","","other molecular function","CRYZL1","ENSG00000205758","","","",384.7,386.4,419.3,356.1,408.9,398.9,1.022768279061775,0.0324793215096251,0.6774375783045387,0.16913071616844,0.8249271072055268,0.08358442519191185,6412]
["High","O95831-1","Apoptosis-inducing factor 1, mitochondrial [OS=Homo sapiens]",29,16,46,16,613,66.9,8.95,115.94,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","AIFM1","ENSG00000156709","Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70","","Apoptosis; Necroptosis",1979.9,2040.1,1994.2,2075.2,2134.8,2172.2,0.9423396321017831,-0.08568097428538678,0.021711357521003612,1.6633130210665812,0.12319933104941586,0.9093916503074383,1376]
["High","O95834","echinoderm microtubule-associated protein-like 2 [OS=Homo sapiens]",6,4,5,4,649,70.6,6.32,10.72,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","EML2","ENSG00000125746","","","",356.9,334.5,311.5,322.4,367.8,324.1,0.9887607216799763,-0.016306661275973997,0.8572435832663073,0.06689575702954127,0.9300205499712835,0.03150745505839897,7197]
["Medium","O95857","Tetraspanin-13 [OS=Homo sapiens]",4,1,1,1,204,22.1,7.93,1.89,"other biological processes","plasma membrane;other membranes","other molecular function","TSPAN13","ENSG00000106537","","","",110.9,87.7,90.9,98.2,93.9,89.4,1.0284191829484903,0.04042842590900716,0.7462620640525455,0.12710863501285918,0.8663119530363181,0.062325693332840514,6726]
["High","O95861-1","3'(2'),5'-bisphosphate nucleotidase 1 [OS=Homo sapiens]",47,11,21,11,308,33.4,5.69,35.66,"other metabolic processes;developmental processes","cytosol","other molecular function","BPNT1; HEL20","ENSG00000162813; ENSPTRG00000001996","","Cytosolic sulfonation of small molecules","Sulfur metabolism; Metabolic pathways",814.4,878.1,886.4,845.5,916.7,844.7,0.9892592734665695,-0.015579410583726219,0.7911485663264617,0.10174195458412963,0.8913835506316036,0.04993538453730099,6930]
["High","O95863","Zinc finger protein SNAI1 [OS=Homo sapiens]",4,1,1,1,264,29.1,8.65,2.92,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SNAI1","ENSG00000124216","Neural crest differentiation; Mesodermal commitment pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Epithelial to mesenchymal transition in colorectal cancer; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; CCL18 signaling pathway","Regulation of PTEN gene transcription","Adherens junction",21.9,17.6,16.6,22.3,15,18.6,1.003577817531306,0.005152487765602781,0.9812171993626021,0.008234847825207283,0.9920165599667483,3.4810780049434223E-3,7723]
["High","O95864","fatty acid desaturase 2 [OS=Homo sapiens]",16,7,10,7,444,52.2,8.82,19.47,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","FADS2","ENSG00000134824","PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis","alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","alpha-Linolenic acid metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway",429,405.5,425.6,530.9,549.1,546.5,0.7747310175222871,-0.36823259359082805,1.9228697661347117E-4,3.7160501290555277,0.016319312102151987,1.7872981517424478,92]
["High","O95865","N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [OS=Homo sapiens]",48,10,40,9,285,29.6,6.01,100.42,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion","other molecular function","DDAH2","ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076","Nitric oxide metabolism in cystic fibrosis","eNOS activation","",1387.1,1372.5,1314.7,1307.1,1364.5,1344.3,1.0145421947757665,0.020828867980579112,0.5219589092174436,0.2823636851252072,0.7222142766559985,0.14133393073661313,5643]
["High","O95873","Uncharacterized protein C6orf47 [OS=Homo sapiens]",4,1,1,1,294,31.7,6.37,2.78,"","","","C6orf47","ENSG00000203623; ENSG00000204439; ENSG00000226103; ENSG00000226531; ENSG00000228177; ENSG00000228435; ENSG00000235360","","","",43.2,45.4,46.3,46.3,48.5,51.7,0.9208191126279862,-0.11901031636134289,0.10057603418377999,0.9975054930544913,0.2845281430822298,0.5458747704610736,2760]
["High","O95881","Thioredoxin domain-containing protein 12 [OS=Homo sapiens]",31,5,18,5,172,19.2,5.4,40.09,"other biological processes","ER/Golgi","other molecular function","TXNDC12","ENSG00000117862","","","Glutathione metabolism; Metabolic pathways",1198.1,1050.7,1019.5,1008.3,921.9,909.8,1.1508098591549296,0.2026494860203865,0.08680295096077836,1.061465510259019,0.26474900043037397,0.5771656709122333,2560]
["High","O95900","Mitochondrial mRNA pseudouridine synthase TRUB2 [OS=Homo sapiens]",8,3,6,2,331,36.7,8.98,11.66,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","TRUB2","ENSG00000167112","","","",191.6,194.2,179.9,188,196.3,164.8,1.030231287561464,0.04296825969951012,0.6229245390405813,0.2055645605048886,0.7917621358992118,0.10140527116581656,6143]
["High","O95905","Protein ecdysoneless homolog [OS=Homo sapiens]",21,9,9,9,644,72.7,4.87,11.41,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ECD","ENSG00000122882","","","",225.8,219.2,220.8,300.7,276.7,301.8,0.7572793448589626,-0.4011025158089681,1.0790065878396613E-3,2.966975903738147,0.03074774977318276,1.5121866618998998,274]
["High","O95983-1","methyl-CpG-binding domain protein 3 [OS=Homo sapiens]",29,8,27,8,291,32.8,5.34,30.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MBD3","ENSG00000071655; ENSPTRG00000010209","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome","HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; Regulation of TP53 Activity through Acetylation","",922.5,880.7,850.1,939.1,798.9,792.5,1.048527958901403,0.06836533127772715,0.477058473685386,0.3214283856506636,0.6892806370346954,0.16160392134202115,5404]
["High","O95985","DNA topoisomerase 3-beta-1 [OS=Homo sapiens]",13,7,11,7,862,96.6,8.12,19.99,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP3B","ENSG00000100038","","","Homologous recombination; Fanconi anemia pathway",291.1,309.8,293.7,284.9,276,287.3,1.0547040792265976,0.07683827540816404,0.08478702892263798,1.0716705828635833,0.26166684657231515,0.5822512993807658,2530]
["High","O95989","Diphosphoinositol polyphosphate phosphohydrolase 1 [OS=Homo sapiens]",25,3,10,3,172,19.5,6.34,26.94,"cell-cell signaling;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT3","ENSG00000272325","","Synthesis of pyrophosphates in the cytosol","",523.8,504.3,494.4,477.8,547.6,502.2,0.996661429693637,-0.00482459694145708,0.9426378162015743,0.0256551414507367,0.9734315657851993,0.011694574854320523,7561]
["High","O95995","Growth arrest-specific protein 8 [OS=Homo sapiens]",4,2,2,2,478,56.3,7.94,2.7,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","GAS8","ENSG00000141013","Ciliopathies","Activation of SMO","",32.4,37,32.9,34.2,35.9,35.3,0.9705882352941178,-0.04306872189188581,0.5389391436687273,0.26846027203218764,0.7324694227616053,0.13521050039785626,5745]
["High","O95997","Securin [OS=Homo sapiens]",7,1,1,1,202,22,6.6,2.33,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PTTG1","ENSG00000164611","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition","APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids","Cell cycle; Oocyte meiosis; Human T-cell leukemia virus 1 infection",30.2,25.1,19.9,27.3,22,20.5,1.0773638968481374,0.10750562546798494,0.6450034855761476,0.19043793844628729,0.8056610486927789,0.09384763269045514,6251]
["Medium","O95999","B-cell lymphoma/leukemia 10 [OS=Homo sapiens]",3,1,1,1,233,26.2,5.74,2.26,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BCL10","ENSG00000142867","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling","NF-kappa B signaling pathway; C-type lectin receptor signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway; Shigellosis; Tuberculosis",74.5,69.4,75.5,97.6,61.8,53.3,1.0314997649271276,0.04474349244252083,0.8784482093239859,0.05628383811613795,0.941901073661313,0.02599470805542756,7282]
["High","O96000","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [OS=Homo sapiens]",19,3,3,3,172,20.8,8.48,6.91,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB10","ENSG00000140990","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Modulators of TCR signaling and T cell activation; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",73.7,62.4,58.7,69.6,47.9,55.8,1.1240623196768609,0.16872202292217242,0.40921284199816366,0.3880507456308803,0.6358475363824203,0.19664700706477134,5025]
["High","O96005-1","Cleft lip and palate transmembrane protein 1 [OS=Homo sapiens]",26,10,31,10,669,76,6.3,69.79,"developmental processes;other biological processes","plasma membrane;other membranes;other cell component","","CLPTM1","ENSG00000104853","","","",1017.2,1047.1,1031.6,903.8,979.8,1029.2,1.0628604778906894,0.0879522261576476,0.17875004429014282,0.7477538419187014,0.398424306542231,0.39965417457775837,3503]
["High","O96006","zinc finger BED domain-containing protein 1 [OS=Homo sapiens]",10,7,11,7,694,78.1,6.1,24.05,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED1","ENSG00000214717","","SUMOylation of chromatin organization proteins","",511.4,499.2,500.6,613.2,618.8,574,0.836766334440753,-0.257103285979851,0.002545443670351787,2.5942365092831228,0.043680932259575284,1.3597081012816,455]
["High","O96007","molybdopterin synthase catalytic subunit [OS=Homo sapiens]",23,3,4,3,188,20.9,5.44,8.19,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","MOCS2","ENSG00000164172","","Molybdenum cofactor biosynthesis","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system",290.9,310.7,310.2,253.5,239,276,1.1864671437865972,0.24667214928663136,0.019170810404621555,1.7173595278722718,0.11558740358245954,0.9370894916309068,1295]
["High","O96008","Mitochondrial import receptor subunit TOM40 homolog [OS=Homo sapiens]",45,12,98,12,361,37.9,7.25,220.56,"cell organization and biogenesis;transport","other membranes;cytosol;mitochondrion;other cell component","transporter activity","TOMM40","ENSG00000130204","IL-18 signaling pathway","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",2574.3,2469.4,2596.5,2268.4,2941.6,2735.4,0.9615878369874393,-0.056509447204405115,0.6425229886492725,0.19211132921858418,0.804106346429479,0.09468651019031207,6239]
["High","O96011-1","Peroxisomal membrane protein 11B [OS=Homo sapiens]",7,2,3,2,259,28.4,9.85,7.3,"cell organization and biogenesis;signal transduction","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PEX11B","ENSG00000131779; ENSPPAG00000024465; ENSPTRG00000001203","","Class I peroxisomal membrane protein import","Peroxisome",231.5,230.7,210.6,224.3,225.4,229.3,0.9908689248895434,-0.013233868876950008,0.7826071439367221,0.10645619201144815,0.885978915449895,0.05257661334175427,6897]
["High","O96013-1","serine/threonine-protein kinase PAK 4 [OS=Homo sapiens]",12,6,13,6,591,64,9.73,26.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","PAK4","ENSG00000130669","Integrin-mediated cell adhesion; Focal adhesion; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle","ErbB signaling pathway; Ras signaling pathway; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Regulation of actin cytoskeleton; Human immunodeficiency virus 1 infection; MicroRNAs in cancer; Renal cell carcinoma",413.5,403.7,406.5,456.8,399.4,449.1,0.9374856354860951,-0.09313150974800642,0.20981021717050272,0.6781733667014355,0.4383725383107533,0.35815665989243767,3737]
["High","O96017-1","Serine/threonine-protein kinase Chk2 [OS=Homo sapiens]",26,11,24,11,543,60.9,5.91,43.01,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","CHEK2","ENSG00000183765","miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection",732.2,729.2,725.3,900.1,968.6,920.3,0.7840444603800646,-0.35099262810919213,6.0002590270451066E-4,3.2218300010183274,0.023425011241584096,1.6303201920236732,200]
["High","O96018","amyloid-beta A4 precursor protein-binding family A member 3 [OS=Homo sapiens]",3,2,2,2,575,61.4,4.94,2.99,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","APBA3","ENSG00000011132","","Neurexins and neuroligins","",104.6,107.6,113.9,90.7,101.6,124.8,1.0283822138126775,0.040376563644626266,0.7877535039655654,0.10360965638687239,0.8889694116148482,0.05111318233173096,6919]
["High","O96019-1","Actin-like protein 6A [OS=Homo sapiens]",47,18,54,18,429,47.4,5.6,115.33,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","ACTL6A","ENSCANG00000034249; ENSCATG00000017467; ENSCCAG00000029449; ENSCJAG00000013036; ENSCSAG00000013017; ENSG00000136518; ENSGGOG00000015710; ENSMFAG00000030153; ENSMMUG00000009742; ENSPANG00000024431; ENSPPAG00000031814; ENSPTRG00000023973; ENSRBIG00000036584; ENSRROG00000035215","Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; UCH proteinases; HATs acetylate histones; DNA Damage Recognition in GG-NER","Thermogenesis; Hepatocellular carcinoma",3157,3216.4,3256.9,3284.3,3099.5,3214.4,1.0033443770707007,0.004816865988851553,0.8696720982631678,0.060644463195115884,0.9367360661110241,0.028382758288715424,7249]
["High","O96028-1","Histone-lysine N-methyltransferase NSD2 [OS=Homo sapiens]",17,19,38,19,1365,152.2,8.69,80.41,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD2","ENSG00000109685","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Lysine degradation; Metabolic pathways; Transcriptional misregulation in cancer",1495.4,1500.4,1529.1,1828.4,1795.9,1872.4,0.8232030127167208,-0.2806798327435284,1.899026660929212E-4,3.721468938046995,0.016294066119269545,1.787970525709453,91]
["High","P00167-1","Cytochrome b5 [OS=Homo sapiens]",39,4,9,4,134,15.3,4.96,29.2,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","CYB5A","ENSG00000166347; ENSPTRG00000010111","Oxidation by cytochrome P450","Vitamin C (ascorbate) metabolism","",383.3,341.6,319.5,387.6,324.3,333.1,0.9994258373205743,-0.000828579542765322,0.994492629844983,2.3984310709837444E-3,0.9971745799190481,1.228801108496463E-3,7787]
["High","P00338-1","L-lactate dehydrogenase A chain [OS=Homo sapiens]",72,24,204,21,332,36.7,8.27,395.17,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HEL-S-133P; LDHA","ENSG00000134333; ENSG00000288299","Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glycolysis and gluconeogenesis","Pyruvate metabolism","Glycolysis / Gluconeogenesis; Cysteine and methionine metabolism; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer",6437.1,6463,6684.4,6096.8,6986.4,6686,0.9906571839022318,-0.013542194537817851,0.8325137090147756,0.07960860622951174,0.9163049111907764,0.0379599857068003,7094]
["High","P00367","Glutamate dehydrogenase 1, mitochondrial [OS=Homo sapiens]",48,24,107,10,558,61.4,7.8,248.82,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","GLUD1","ENSG00000148672","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension","Transcriptional activation of mitochondrial biogenesis; Glutamate and glutamine metabolism","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Nitrogen metabolism; Metabolic pathways; Carbon metabolism; Necroptosis; Proximal tubule bicarbonate reclamation",4409.5,4264.2,4185.3,4488.7,4522.5,4612.7,0.9438560177335417,-0.08336129710606881,0.027714459770965094,1.5572935825514218,0.14060721370480536,0.8519923977242652,1539]
["High","P00374","dihydrofolate reductase [OS=Homo sapiens]",38,6,19,6,187,21.4,7.42,30.46,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;mitochondrion","nucleic acid binding activity;other molecular function","DHFR","ENSG00000228716","Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Ethanol effects on histone modifications; Nucleotide metabolism","G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","One carbon pool by folate; Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance",577.9,579.6,581.4,640.1,602.8,606.7,0.940149221453287,-0.08903833387907414,0.03600943317011956,1.4435837148693909,0.15993268156558219,0.7960627809485087,1758]
["High","P00387","NADH-cytochrome b5 reductase 3 [OS=Homo sapiens]",46,13,43,13,301,34.2,7.59,99.19,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CYB5R3","ENSG00000100243","Oxidation by cytochrome P450","Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism","Amino sugar and nucleotide sugar metabolism",1598.7,1709.3,1652.8,1539.7,1684.5,1618.8,1.0243237662605824,0.03467179165761719,0.49720849951983986,0.3034614559293978,0.7050860814113531,0.1517578583280738,5506]
["High","P00390","Glutathione reductase, mitochondrial [OS=Homo sapiens]",48,18,57,17,522,56.2,8.5,129.23,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","other molecular function","GSR","ENSG00000104687","Glutathione metabolism; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II","","Glutathione metabolism; Metabolic pathways; Thyroid hormone synthesis; Diabetic cardiomyopathy",2018,1965.4,1977.4,1934.1,2045.8,2084.6,0.982900486437464,-0.02488273629777227,0.5099235176130111,0.29249495795990366,0.7131439773459415,0.1468227811516977,5583]
["High","P00403","Cytochrome c oxidase subunit 2 [OS=Homo sapiens]",28,5,19,5,227,25.5,4.82,32.11,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO2","ENSG00000198712","Electron transport chain: OXPHOS system in mitochondria; Endothelin pathways; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly; CCL18 signaling pathway","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",997.9,949,1005.4,882.4,893.4,906.6,1.1006188487921265,0.13831494105419564,0.009097534834197538,2.0410762728375436,0.07901396216397595,1.1022961599121368,899]
["High","P00441","Superoxide dismutase [Cu-Zn] [OS=Homo sapiens]",92,14,102,14,154,15.9,6.13,283.23,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SOD1","ENSG00000142168","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species","Peroxisome; Longevity regulating pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis",4678.9,4108.4,4002.1,3800.6,3553.4,3814.9,1.145090384908093,0.19546147842023098,0.07570507661928619,1.1208749966714167,0.2455775813225536,0.6098112822878113,2407]
["High","P00488","Coagulation factor XIII A chain [OS=Homo sapiens]",7,4,7,4,732,83.2,6.09,10.39,"protein metabolism;other metabolic processes;stress response","non-structural extracellular;other cell component","other molecular function","F13A1","ENSG00000124491","Complement system","Platelet degranulation ; Interleukin-4 and Interleukin-13 signaling; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades; Coronavirus disease",289.5,253,252.1,233.4,236,253.1,1.0997923875432525,0.13723120581269518,0.1561438491324016,0.8064751189616105,0.37147202133631674,0.4300738910200495,3282]
["High","P00491","purine nucleoside phosphorylase [OS=Homo sapiens]",83,19,70,19,289,32.1,6.95,202.75,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PNP","ENSG00000198805","VEGFA-VEGFR2 signaling pathway","Neutrophil degranulation; Purine catabolism; Purine salvage","Purine metabolism; Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways",2803.4,2868.9,2884.7,2672.4,3209.9,2899,0.9744570849418652,-0.03732944424756419,0.6602880902007765,0.1802665361462395,0.8135599508107405,0.08961043861284372,6337]
["High","P00492","Hypoxanthine-guanine phosphoribosyltransferase [OS=Homo sapiens]",42,6,24,6,218,24.6,6.68,36.92,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HPRT1","ENSG00000165704","Mesodermal commitment pathway; Nucleotide metabolism","Purine salvage","Purine metabolism; Drug metabolism; Metabolic pathways",289.6,277.9,272.8,318.7,290.7,303.5,0.9204732172198486,-0.11955235044008976,0.06345703551457632,1.1975202204444542,0.22050402015923984,0.6565834882049477,2247]
["High","P00505","Aspartate aminotransferase, mitochondrial [OS=Homo sapiens]",53,20,119,20,430,47.5,9.01,261.14,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","other molecular function","GOT2","ENSG00000125166","Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis","Glyoxylate metabolism and glycine degradation; Gluconeogenesis; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Cysteine and methionine metabolism; Arginine and proline metabolism; Tyrosine metabolism; Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Fat digestion and absorption",5507.5,5414.9,5584.6,5472.1,5644.8,5794.4,0.9760929082920885,-0.03490961927859819,0.2696012927520555,0.5692780296673627,0.5052921012501319,0.2964574906204544,4166]
["High","P00519-2","Isoform IB of Tyrosine-protein kinase ABL1 [OS=Homo sapiens]",12,9,13,9,1149,124.9,8.84,29.2,"","","","ABL1","","","","",447,477.2,497.3,516,521.1,498.5,0.9256967960406356,-0.1113883662820597,0.0779666874109215,1.1080909173596645,0.24928906441624693,0.6032967723098929,2442]
["High","P00533-1","epidermal growth factor receptor [OS=Homo sapiens]",12,9,10,9,1210,134.2,6.68,20.89,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function","EGFR","ENSG00000146648","Androgen receptor signaling pathway; Glioblastoma signaling pathways; AGE/RAGE pathway; Gastric cancer network 2; Spinal cord injury; Aryl hydrocarbon receptor pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Bladder cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; ERK pathway in Huntington's disease; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Extracellular vesicles in the crosstalk of cardiac cells; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Regulatory circuits of the STAT3 signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway","Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF/MAP kinase cascade; Cargo recognition for clathrin-mediated endocytosis; HCMV Early Events; NOTCH3 Activation and Transmission of Signal to the Nucleus; Signaling by ERBB4; SHC1 events in ERBB2 signaling; GRB2 events in ERBB2 signaling; PI3K events in ERBB2 signaling; ERBB2 Regulates Cell Motility; ERBB2 Activates PTK6 Signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Signal transduction by L1; GRB2 events in EGFR signaling; GAB1 signalosome; SHC1 events in EGFR signaling; EGFR downregulation; EGFR interacts with phospholipase C-gamma; Inhibition of Signaling by Overexpressed EGFR; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PLCG1 events in ERBB2 signaling; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; PTK6 promotes HIF1A stabilization; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors; Signaling by ERBB2 ECD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Calcium signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; Endocytosis; PI3K-Akt signaling pathway; Focal adhesion; Adherens junction; Gap junction; JAK-STAT signaling pathway; Regulation of actin cytoskeleton; GnRH signaling pathway; Estrogen signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Epithelial cell signaling in Helicobacter pylori infection; Shigellosis; Hepatitis C; Human cytomegalovirus infection; Human papillomavirus infection; Coronavirus disease; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer",253.2,253.8,248.1,258.4,259.9,286.3,0.9384787472035795,-0.0916040207434944,0.14865910439302835,0.8278084879620845,0.362049372146215,0.44123220132157515,3206]
["High","P00558","phosphoglycerate kinase 1 [OS=Homo sapiens]",78,30,422,25,417,44.6,8.1,981.27,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol","kinase activity;other molecular function","PGK1","ENSG00000102144","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glycolysis and gluconeogenesis","Gluconeogenesis; Glycolysis; Manipulation of host energy metabolism","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway",20024.3,19961.7,20145.1,19444.8,19104.5,19412.6,1.0374245840802319,0.053006463083116566,0.003950847458115903,2.403309738067838,0.054406026372079315,1.2643529923021093,567]
["High","P00568","Adenylate kinase isoenzyme 1 [OS=Homo sapiens]",48,9,23,9,194,21.6,8.63,54.93,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK1","ENSG00000106992","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors",1345.9,1319.5,1228.9,1275.1,1262,1287.3,1.0182773768434266,0.026130602365194478,0.5545863561842801,0.25603081904731473,0.7436390638995121,0.12863780449670462,5823]
["High","P00734","Prothrombin [OS=Homo sapiens]",5,2,5,2,622,70,5.9,5.85,"protein metabolism;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","F2","ENSG00000180210","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; IL1 and megakaryocytes in obesity; Regulation of actin cytoskeleton; Complement and coagulation cascades","Cell surface interactions at the vascular wall; Regulation of Complement cascade; G alpha (q) signalling events; Peptide ligand-binding receptors; Thrombin signalling through proteinase activated receptors (PARs); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Defective F8 cleavage by thrombin; Gamma-carboxylation of protein precursors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Platelet Aggregation (Plug Formation); Defective factor XII causes hereditary angioedema","Phospholipase D signaling pathway; Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Platelet activation; Regulation of actin cytoskeleton; Pathogenic Escherichia coli infection; Coronavirus disease; Pathways in cancer",82.4,58.7,63.3,64.7,62.4,62.2,1.0797675647120972,0.1107207852339162,0.5284287279669727,0.27701358004617915,0.7243629754154007,0.14004375601634372,5696]
["High","P00747","Plasminogen [OS=Homo sapiens]",5,4,13,4,810,90.5,7.24,18.2,"cell organization and biogenesis;protein metabolism;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLG","ENSG00000122194","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; Complement system; Fibrin complement receptor 3 signaling pathway; Complement and coagulation cascades","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by PDGF; Platelet degranulation ; Activation of Matrix Metalloproteinases; Dissolution of Fibrin Clot","Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Staphylococcus aureus infection; Influenza A",557.9,611.6,653.1,611,672.5,643.3,{"$f":"AVERAGE(T962:V962)/AVERAGE(W962:Y962)","v":0.9459206975295827},{"$f":"LOG(Z962,2)","v":-0.08020885643526196},{"$f":"TTEST(T962:V962,W962:Y962,2,2)","v":0.349136169482024},{"$f":"-LOG10(AB962)","v":0.45700515722201085},{"$f":"AB962*7808/AF962","v":0.5859963910824685},{"$f":"-LOG10(AD962)","v":0.23210505861978625},4652]
["High","P00750-1","Tissue-type plasminogen activator [OS=Homo sapiens]",5,2,2,2,562,62.9,7.8,5.04,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;other molecular function","PLAT","ENSG00000104368","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; NOTCH1 regulation of endothelial cell calcification; Fibrin complement receptor 3 signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Complement and coagulation cascades","Signaling by PDGF; Dissolution of Fibrin Clot","Apelin signaling pathway; Complement and coagulation cascades; Transcriptional misregulation in cancer; Prostate cancer; Fluid shear stress and atherosclerosis",58.6,55.5,54.6,72.1,62.5,67.9,0.8330864197530863,-0.26346193437178395,0.020528542878161034,1.687641875881842,0.11988546207380804,0.9212334784851908,1337]
["High","P00813","adenosine deaminase [OS=Homo sapiens]",25,6,9,6,363,40.7,5.95,14.19,"cell adhesion;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ADA","ENSG00000196839","","Purine salvage","Purine metabolism; Metabolic pathways; Primary immunodeficiency",396.3,414.8,459.6,430.3,445,414,0.9855735670518887,-0.020964531219133224,0.7806414409863806,0.1075483975666932,0.8845230548863241,0.0532908428227463,6891]
["High","P00846","ATP synthase subunit A [OS=Homo sapiens]",4,1,5,1,226,24.8,10.1,12.85,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ATP6","ENSG00000198899","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation","Cristae formation; Formation of ATP by chemiosmotic coupling","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",317,358.7,358,262,308.2,326.8,1.152396878483835,0.20463765776419526,0.126737503562614,0.8970948517291562,0.3272375753362732,0.48513683389968976,3024]
["High","P00918","Carbonic anhydrase 2 [OS=Homo sapiens]",13,3,4,3,260,29.2,7.4,8.46,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CA2","ENSG00000104267","Proximal tubule transport","Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Nitrogen metabolism; Metabolic pathways; Proximal tubule bicarbonate reclamation; Collecting duct acid secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion",187.9,182.3,180.5,173.1,164.2,169.9,1.0857649842271297,0.11871186301147163,0.013347750805877736,1.874591909946706,0.09491733906401946,1.0226544454021438,1098]
["High","P00966","Argininosuccinate synthase [OS=Homo sapiens]",19,8,18,8,412,46.5,8.02,33.05,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASS1","ENSG00000130707","Alanine and aspartate metabolism; Amino acid metabolism","Urea cycle","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids; Fluid shear stress and atherosclerosis",910.3,850.5,880,883.6,910.6,900.2,0.9801068883610452,-0.028988999843860008,0.3995897198570935,0.3983856932858123,0.6276396163033969,0.2022896517661761,4971]
["High","P01023","alpha-2-macroglobulin [OS=Homo sapiens]",5,8,58,8,1474,163.2,6.46,101.45,"other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","A2M","ENSG00000175899","Complement system; Complement and coagulation cascades","Degradation of the extracellular matrix; Platelet degranulation ; HDL assembly; Intrinsic Pathway of Fibrin Clot Formation","Complement and coagulation cascades",2276.6,1821.3,1978.6,1617.2,1657.5,2054,1.140334415523486,0.18945697251908428,0.26609246713653306,0.5749674198016465,0.5019690706455787,0.299323041543771,4139]
["High","P01024","Complement C3 [OS=Homo sapiens]",1,2,4,2,1663,187,6.4,5.7,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","C3","ENSG00000125730","Allograft rejection; Complement system; TYROBP causal network in microglia; Cells and molecules involved in local acute inflammatory response ; 16p11.2 distal deletion syndrome; Complement system in neuronal development and plasticity; Acquired partial lipodystrophy / Barraquer-Simons syndrome; Complement activation; Complement and coagulation cascades","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; G alpha (i) signalling events; Neutrophil degranulation; Peptide ligand-binding receptors; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Purinergic signaling in leishmaniasis infection; Alternative complement activation; Activation of C3 and C5","Neuroactive ligand-receptor interaction; Phagosome; Complement and coagulation cascades; Neutrophil extracellular trap formation; Alcoholic liver disease; Shigellosis; Pertussis; Legionellosis; Leishmaniasis; Chagas disease; Staphylococcus aureus infection; Tuberculosis; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Coronavirus disease; Viral carcinogenesis; Systemic lupus erythematosus",55,42.1,48.8,36.4,48,56.1,1.0384341637010674,0.054409752809602224,0.8049617733657559,0.09422474324766286,0.9004500754211779,0.045540361212188574,6980]
["High","P01033","Metalloproteinase inhibitor 1 [OS=Homo sapiens]",10,2,2,2,207,23.2,8.1,4.81,"stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","TIMP1","ENSG00000102265","Matrix metalloproteinases; Mammary gland development pathway - Puberty (Stage 2 of 4); IL1 and megakaryocytes in obesity; Lung fibrosis; IL-6 signaling pathway; IL-18 signaling pathway; Burn wound healing; CCL18 signaling pathway","Interleukin-4 and Interleukin-13 signaling; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-10 signaling; Activation of Matrix Metalloproteinases","HIF-1 signaling pathway",129.7,102.6,113.9,117.3,126.9,114.7,0.9646140986347171,-0.05197619844943887,0.6516677041216865,0.18597380159038804,0.8091955206396514,0.09194652996310414,6288]
["High","P01034","Cystatin-C [OS=Homo sapiens]",12,1,1,1,146,15.8,8.75,0,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CST3","ENSG00000101439","","Neutrophil degranulation; Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Salivary secretion",33.1,22.6,29.7,33,36.3,23.5,0.9202586206896552,-0.11988873550708162,0.6430058484211274,0.1917850769584023,0.80445275828748,0.09449945488064979,6241]
["High","P01111","GTPase NRas [OS=Homo sapiens]",69,10,37,3,189,21.2,5.17,55.68,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","NRAS","ENSG00000213281","Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling","Neutrophil degranulation; FCERI mediated MAPK activation; Regulation of RAS by GAPs; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",1272.9,1239.9,1192.2,1239.3,1346.8,1281.1,0.9580575093090609,-0.06181583568502402,0.23876016896230776,0.6220381224450813,0.4707675250650755,0.3271935037119581,3960]
["High","P01112","GTPase HRas [OS=Homo sapiens]",55,8,36,1,189,21.3,5.31,57.96,"stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","HRAS","ENSG00000174775; ENSG00000276536","Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; Pathways affected in adenoid cystic carcinoma; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; IL-2 signaling pathway; Malignant pleural mesothelioma; Alzheimer's disease; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling","Regulation of RAS by GAPs; EPHB-mediated forward signaling; FCERI mediated MAPK activation; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Focal adhesion; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Salmonella infection; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",76.8,60.5,55.2,70.2,66.2,48.9,1.0388559093362115,0.054995564442360256,0.8074291101886985,0.09289559705300383,0.9020470013382971,0.04477083286819286,6989]
["High","P01116-2","Isoform 2B of GTPase KRas [OS=Homo sapiens]",62,9,38,3,188,21.4,8.12,58.59,"","","","KRAS","","","","",479.7,465.7,447.3,524.9,520,465.6,0.9220125786163522,-0.11714166203790581,0.1375332024113437,0.8615924445003051,0.3446274853747663,0.46265008884219655,3116]
["High","P01130","Low-density lipoprotein receptor [OS=Homo sapiens]",10,8,10,8,860,95.3,5.05,17.03,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LDLR","ENSG00000130164","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M signaling pathway; PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Lipid particles composition; Wnt signaling pathway and pluripotency; Statin inhibition of cholesterol production; Bile acids synthesis and enterohepatic circulation ; Metabolic pathway of LDL, HDL and TG, including diseases; Orexin receptor pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; DNA damage response (only ATM dependent)","Cargo recognition for clathrin-mediated endocytosis; Retinoid metabolism and transport; LDL clearance; Chylomicron clearance","Endocytosis; Ovarian steroidogenesis; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Cushing syndrome; Bile secretion; Cholesterol metabolism; Toxoplasmosis; Hepatitis C; Lipid and atherosclerosis",395.8,362.1,376.9,666.7,667.6,713.6,0.5541286195615021,-0.8517072137993275,7.6563365558976107E-5,4.115978984171051,0.011279372797820481,1.947715049113204,53]
["Medium","P01350","Gastrin [OS=Homo sapiens]",16,1,1,1,101,11.4,5.19,0,"signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","GAST","ENSG00000184502","Gastrin signaling pathway","Gastrin-CREB signalling pathway via PKC and MAPK","Gastric acid secretion",18.4,26.9,20.4,19.7,17.9,19.8,1.1445993031358885,0.19484263364664184,0.3536343248871146,0.451445587591158,0.589869004212474,0.22924442405996467,4681]
["Low","P01563","Interferon alpha-2 [OS=Homo sapiens]",10,1,1,1,188,21.5,6.76,0,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","IFNA2","ENSG00000188379","PI3K-Akt signaling pathway; Overview of interferons-mediated signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; SARS coronavirus and innate immunity; Overview of proinflammatory and profibrotic mediators; Type II interferon signaling (IFNG); Toll-like receptor signaling pathway","Factors involved in megakaryocyte development and platelet production; Regulation of IFNA signaling; TRAF6 mediated IRF7 activation","Cytokine-cytokine receptor interaction; PI3K-Akt signaling pathway; Necroptosis; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Alcoholic liver disease; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Autoimmune thyroid disease; Lipid and atherosclerosis",39.8,56.9,56.1,65.2,35.5,56.5,0.9720101781170483,-0.0409566742228579,0.8949510415466491,0.048200722189902,0.9508474258261308,0.021889164910913844,7349]
["High","P01834","immunoglobulin kappa constant [OS=Homo sapiens]",19,1,1,1,107,11.8,6.52,2.75,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGKC","","","FCERI mediated NF-kB activation; Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers","",9.8,13.5,17.9,20.9,10,15.3,0.8917748917748918,-0.16524851423283915,0.6927554522063311,0.15942004749620942,0.8351141841635066,0.07825413989146732,6477]
["Medium","P01854","immunoglobulin heavy constant epsilon [OS=Homo sapiens]",4,1,1,1,428,47,8.06,0,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHE","ENSG00000211891; ENSG00000276192","","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; Interleukin-4 and Interleukin-13 signaling","",42.7,45.9,52.3,44.1,40.9,46.7,1.0698557327258922,0.09741626605312223,0.4031248669794885,0.3945604113262909,0.6302761236235175,0.20046914468298443,4994]
["High","P02042","Hemoglobin subunit delta [OS=Homo sapiens]",13,2,12,2,147,16,8.05,25.21,"other metabolic processes;transport;other biological processes","cytosol;other cell component","other molecular function","HBD","ENSG00000223609","VEGFA-VEGFR2 signaling pathway","Factors involved in megakaryocyte development and platelet production","",384.8,371.1,320.2,306.1,312.5,383,1.0743809904153356,0.10350568374606262,0.4747654933453001,0.3235208537324337,0.6877493454619857,0.16256981426053704,5390]
["High","P02452","Collagen alpha-1(I) chain [OS=Homo sapiens]",9,11,16,11,1464,138.9,5.8,18.87,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi;other cell component","extracellular structural activity;other molecular function","COL1A1","ENSG00000108821","Focal adhesion; Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miR-509-3p alteration of YAP1/ECM axis; PI3K-Akt signaling pathway; Inflammatory response pathway; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Angiotensin II receptor type 1 pathway; Burn wound healing; CCL18 signaling pathway; NRP1-triggered signaling pathways in pancreatic cancer","GPVI-mediated activation cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Collagen degradation; Integrin cell surface interactions; ECM proteoglycans; Collagen chain trimerization; Syndecan interactions; MET activates PTK2 signaling; RUNX2 regulates osteoblast differentiation; Anchoring fibril formation; Crosslinking of collagen fibrils; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); Scavenging by Class A Receptors; GP1b-IX-V activation signalling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Platelet activation; Relaxin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Protein digestion and absorption; Amoebiasis; Human papillomavirus infection; Proteoglycans in cancer; Diabetic cardiomyopathy",418.1,303.2,370.5,282.2,258.2,439,1.1147641413110068,0.15673850103765158,0.5993419089934273,0.2223253531925096,0.7750350489269096,0.11067865722095319,6038]
["High","P02458-1","Isoform 1 of Collagen alpha-1(II) chain [OS=Homo sapiens]",3,4,4,4,1418,134.3,8.56,4.78,"","","","COL2A1","","","","",96.9,80,127.9,99.2,55.2,112.1,1.1437148217636024,0.19372736984678404,0.5962377226766377,0.22458055055759005,0.7726845043417737,0.11199779714586065,6025]
["High","P02462","Collagen alpha-1(IV) chain [OS=Homo sapiens]",2,3,6,3,1669,160.5,8.28,20.23,"","","","","","","","",123.1,134.4,110.1,123.4,129.2,146.8,0.9203805708562846,-0.11969756615493789,0.3462928541749405,0.4605564701150247,0.5831042927319248,0.23425376135219378,4637]
["High","P02533","Keratin, type I cytoskeletal 14 [OS=Homo sapiens]",39,20,65,5,472,51.5,5.16,146.33,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KRT14","ENSG00000186847","Corticotropin-releasing hormone signaling pathway","Formation of the cornified envelope; Type I hemidesmosome assembly","Estrogen signaling pathway; Staphylococcus aureus infection",1410.9,1119.1,1277.9,1423.9,1319.6,1787.3,0.840447603072305,-0.2507702161089364,0.21784443005493548,0.6618535398243061,0.4473775144315981,0.349325847695095,3802]
["High","P02538","Keratin, type II cytoskeletal 6A [OS=Homo sapiens]",34,21,119,2,564,60,8,216.7,"cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6A","ENSG00000205420","Ectoderm differentiation; Ectoderm differentiation","Formation of the cornified envelope","",540.7,409.7,513.8,506,488.1,854.8,0.7919303369571096,-0.33655456729307154,0.36591058420546807,0.43662502807680126,0.6005948794358408,0.22141837483806762,4757]
["High","P02545","Prelamin-A/C [OS=Homo sapiens]",65,49,228,46,664,74.1,7.02,519.2,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LMNA","ENSG00000160789","Arrhythmogenic right ventricular cardiomyopathy; Adipogenesis; Fas ligand pathway and stress induction of heat shock proteins; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome","XBP1(S) activates chaperone genes; Signaling by BRAF and RAF1 fusions","Apoptosis; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy",7705.5,8298.3,8215,6639,6383.9,6641.5,1.2316063546307032,0.3005412162843829,1.7426141740942195E-3,2.758798757818373,0.03707447267391734,1.4309250174118269,367]
["High","P02647","Apolipoprotein A-I [OS=Homo sapiens]",8,2,10,1,267,30.8,5.76,21.78,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","APOA1","ENSG00000118137","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5","PPARA activates gene expression; Platelet degranulation ; Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging of heme from plasma; Scavenging by Class B Receptors; Heme signaling; Retinoid metabolism and transport; HDL clearance; Defective ABCA1 causes TGD; HDL assembly; Scavenging by Class A Receptors; ABC transporters in lipid homeostasis; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","PPAR signaling pathway; Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; African trypanosomiasis; Lipid and atherosclerosis",108.4,108,129.8,86.1,92.6,104.5,1.2224576271186445,0.2897844592836417,0.07980411023329537,1.0979747401571647,0.2523736300937911,0.5979560254304616,2469]
["High","P02649","Apolipoprotein E [OS=Homo sapiens]",64,18,94,18,317,36.1,5.73,206.13,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","APOE","ENSG00000130203","Vitamin B12 metabolism; Alzheimer's disease and miRNA effects; Apoptosis-related network due to altered Notch3 in ovarian cancer; ApoE and miR-146 in inflammation and atherosclerosis; Statin inhibition of cholesterol production; Familial hyperlipidemia type 3; Alzheimer's disease","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Retinoid metabolism and transport; Nuclear signaling by ERBB4; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors","Cholesterol metabolism; Alzheimer disease",3653.7,3470.4,3533.8,3357.4,3328.3,3418.9,1.054757239277161,0.07691098946142931,0.037179305810741914,1.4296987233693572,0.1625397647089994,0.7890403732632495,1786]
["High","P02671-1","Fibrinogen alpha chain [OS=Homo sapiens]",2,3,10,3,866,94.9,6.01,16.25,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGA","ENSG00000171560","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway","Regulation of TLR by endogenous ligand; Platelet degranulation ; Integrin cell surface interactions; Amyloid fiber formation; ER-Phagosome pathway; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease",316.2,168.8,195.1,154.5,125.1,251,1.2817565020731247,0.35812221623324625,0.44738721601899883,0.34931642992139295,0.6662596571955641,0.17635648297648088,5243]
["High","P02675","Fibrinogen beta chain [OS=Homo sapiens]",11,7,61,7,491,55.9,8.27,96.62,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGB","ENSG00000171564","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway; Complement and coagulation cascades","Platelet degranulation ; Common Pathway of Fibrin Clot Formation; ER-Phagosome pathway; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease",1407.2,785,825,754.9,658,1084,1.208378389202611,0.27307228806212686,0.5079712805984321,0.29416084092514483,0.7123275429081461,0.14732026286901515,5568]
["High","P02679","Fibrinogen gamma chain [OS=Homo sapiens]",7,3,26,3,453,51.5,5.62,46.62,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGG","ENSG00000171557","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway","ER-Phagosome pathway; Platelet degranulation ; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Staphylococcus aureus infection; Coronavirus disease",508.4,391.8,379.7,347.7,368.9,457.6,1.0900187361607907,0.12435293347371051,0.5430836281143516,0.26513328932073515,0.7354139729998018,0.13346812271428876,5766]
["High","P02748","complement component C9 [OS=Homo sapiens]",4,2,4,2,559,63.1,5.59,2.69,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes","","C9","ENSG00000113600","Allograft rejection; Complement system; Complement system in neuronal development and plasticity; Complement activation; Complement and coagulation cascades","Regulation of Complement cascade; Terminal pathway of complement","Complement and coagulation cascades; Prion disease; Amoebiasis; Coronavirus disease; Systemic lupus erythematosus",108.5,106.3,124.9,90.6,102.4,93.5,1.1856893542757418,0.24572607923493384,0.06095805085908391,1.2149689280640867,0.21654252097712792,0.664456811492923,2198]
["Medium","P02749","Beta-2-glycoprotein 1 [OS=Homo sapiens]",3,1,1,1,345,38.3,7.97,1.61,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;other cell component","enzyme regulator activity;other molecular function","APOH","ENSG00000091583","","Platelet degranulation","Cholesterol metabolism",40,47,43.2,45.4,39.5,51,0.9580573951434878,-0.06181600760175593,0.65064941167074,0.1866529585747699,0.808831492807696,0.09214194732020754,6281]
["High","P02751","fibronectin [OS=Homo sapiens]",30,55,452,55,2386,262.5,5.71,976.91,"","","","","","","","",10355.4,7145.4,7960,6481.7,6159.6,9166.5,1.1675088729720557,0.22343351434105233,0.41971355034804003,0.3770470094723667,0.6425732159053915,0.19207738091166765,5100]
["Medium","P02753","Retinol-binding protein 4 [OS=Homo sapiens]",4,1,1,1,201,23,6.07,1.6,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other cell component","transporter activity;other molecular function","RBP4","ENSG00000138207","Sterol regulatory element-binding proteins (SREBP) signaling; Vitamin A and carotenoid metabolism","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events; Retinoid metabolism disease events","",42.1,45.2,41.9,48.5,41.8,34.8,1.03277378097522,0.04652428052810534,0.7554454820730131,0.12179687174742164,0.8712730168428489,0.05984573577393052,6770]
["Medium","P02760","Protein AMBP [OS=Homo sapiens]",2,1,3,1,352,39,6.25,0,"cell adhesion;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","AMBP","ENSG00000106927","","Scavenging of heme from plasma","",97.4,85.4,103.2,104.8,102.7,104.9,0.9154929577464789,-0.12737930647622756,0.17155091551714238,0.7656069598987896,0.38904140236940105,0.41000417794482774,3443]
["High","P02765","Alpha-2-HS-glycoprotein [OS=Homo sapiens]",7,4,33,4,367,39.3,5.72,45.09,"","","","","","","","",1328.2,1246.2,1414.2,1270.7,1377.5,1374,0.9916463626870868,-0.012102371208672342,0.8606179131345348,0.06518961863631431,0.9313519980255645,0.030886149407191955,7215]
["High","P02768-1","Serum albumin [OS=Homo sapiens]",8,6,55,6,609,69.3,6.28,93.09,"stress response;other biological processes","non-structural extracellular;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","ALB","ENSG00000163631","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; VEGFA-VEGFR2 signaling pathway","Cytoprotection by HMOX1; Scavenging of heme from plasma; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Recycling of bile acids and salts; Heme degradation; HDL remodeling; Heme biosynthesis","Thyroid hormone synthesis",2021.1,1971.1,2060.6,2162.9,2159.5,2182.2,0.9305414629646711,-0.1038576597229779,0.004958706302493347,2.3046316136253564,0.059565505861335466,1.2250051656095766,650]
["High","P02771","Alpha-fetoprotein [OS=Homo sapiens]",3,2,3,2,609,68.6,5.68,8.34,"other metabolic processes;developmental processes;signal transduction","non-structural extracellular;ER/Golgi;other cell component","other molecular function","AFP","ENSG00000081051","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Hippo signaling pathway",100.7,84.5,103.5,110.5,131.4,122.1,0.7931318681318682,-0.3343673428500766,0.04131091788737667,1.3839351553261483,0.1740721245896584,0.7592707699864104,1853]
["High","P02774","vitamin D-binding protein [OS=Homo sapiens]",10,4,11,4,474,52.9,5.54,34.45,"transport","non-structural extracellular","transporter activity;cytoskeletal activity;other molecular function","HEL-S-51","","","","",235,224.3,263.6,242.8,250.6,256.7,0.9637381682442343,-0.05328685163157012,0.5052323766931603,0.29650882642898396,0.7101448059802333,0.14865308504723496,5555]
["High","P02792","Ferritin light chain [OS=Homo sapiens]",40,6,15,6,175,20,5.78,39.57,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTL","ENSG00000087086","Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Ferroptosis; Necroptosis; Mineral absorption",675.5,655.9,668.2,377.4,411.5,408.8,1.669533272104868,0.7394448451365058,2.6944971977868652E-5,4.569522263723675,0.009147232226226019,2.038710295082632,23]
["High","P03905","NADH-ubiquinone oxidoreductase chain 4 [OS=Homo sapiens]",6,2,2,2,459,51.5,9.35,2.5,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-ND4","ENSG00000198886","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",87.1,92.3,95.6,90.2,113.9,101.8,0.8989865969271003,-0.15362848825881834,0.2298022975576784,0.6386456335605557,0.46125869905664596,0.33605543022762807,3890]
["High","P04062","glucosylceramidase [OS=Homo sapiens]",6,3,3,3,536,59.7,7.61,8.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GBA","ENSG00000177628","Sphingolipid pathway","Glycosphingolipid metabolism; Association of TriC/CCT with target proteins during biosynthesis","Other glycan degradation; Sphingolipid metabolism; Metabolic pathways; Lysosome",187.7,198.3,199.8,169.7,186,196.1,1.0616165277274376,0.08626273652609412,0.257121736308209,0.5898612078391003,0.4916988775641675,0.3083007831034621,4083]
["Medium","P04150","Glucocorticoid receptor [OS=Homo sapiens]",1,1,1,1,777,85.6,6.38,2.62,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","NR3C1","ENSG00000113580","Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling","Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression","Neuroactive ligand-receptor interaction",44.6,35.2,38.3,45.1,41.8,43.6,0.9049808429118774,-0.14404084206008955,0.2305498838776994,0.6372350921879572,0.46204658452697045,0.3353142357358997,3896]
["Medium","P04437","T-cell receptor alpha chain V region CTL-L17 [OS=Homo sapiens]",5,1,1,1,139,15.4,8.43,2.06,"","","","","","","","",84.5,103.3,106.4,85.5,96.3,69.5,1.1707122960604857,0.22738657537417487,0.2397762063515268,0.6201939153277771,0.471698820658282,0.32633520957630513,3969]
["High","P04733","Metallothionein-1F [OS=Homo sapiens]",33,2,13,1,61,6.1,7.83,22.3,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1F","ENSG00000198417","Copper homeostasis; Zinc homeostasis","Metallothioneins bind metals","Mineral absorption",693.4,615.3,610.3,628.3,656.6,661.2,0.9860747135296232,-0.02023113311676656,0.7694924572231894,0.11379563288565663,0.8794199511122164,0.05580368590796989,6832]
["High","P04920-1","Anion exchange protein 2 [OS=Homo sapiens]",8,5,9,5,1241,136.9,6.29,19.31,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC4A2","ENSG00000164889","Proximal tubule transport","Bicarbonate transporters","Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion",117.2,128.7,134,131,112.3,143.3,0.9826694257630625,-0.025221925546213504,0.8387423979854477,0.07637140307085988,0.9212126379899249,0.0356401126404619,7109]
["High","P05067-8","Isoform APP751 of Amyloid-beta A4 protein [OS=Homo sapiens]",40,20,50,1,751,84.8,4.79,114.1,"","","","APP","","","","",16.5,23.6,20.6,23.1,22.9,22.4,0.8874269005847953,-0.17229980863021574,0.2824253973295484,0.5490962515857937,0.5184992951679083,0.2852518296411816,4253]
["High","P05141","ADP/ATP translocase 2 [OS=Homo sapiens]",51,18,174,5,298,32.8,9.69,350.99,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","transporter activity;other molecular function","SLC25A5","ENSG00000005022","Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization","Calcium signaling pathway; cGMP-PKG signaling pathway; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Influenza A; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy",9405.7,9604.4,9742.8,8418.5,10021.8,9584,1.0259988652704974,0.03702913536062843,0.6450640282322372,0.19039717570914783,0.8054789592895104,0.0939457997311809,6253]
["High","P05387","60S acidic ribosomal protein P2 [OS=Homo sapiens]",70,5,26,5,115,11.7,4.54,87.36,"protein metabolism;other metabolic processes","cytosol;translational apparatus","other molecular function","RPLP2","ENSG00000177600","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",1008.6,881.2,716.6,990.4,747.2,608.9,1.110760707436608,0.15154804860989252,0.5693343626572667,0.24463260318640645,0.7546023940974264,0.12228182126376429,5891]
["High","P05423","DNA-directed RNA polymerase III subunit RPC4 [OS=Homo sapiens]",29,9,25,9,398,44.4,6.98,52.77,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3D","ENSG00000168495","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",1193.9,1204.6,1112.5,1237.3,1295.4,1232.7,0.9324374568438945,-0.1009211349105811,0.07469618232520804,1.1267015941345968,0.24382432758997677,0.6129229647923345,2392]
["High","P05937","Calbindin [OS=Homo sapiens]",15,2,4,2,261,30,4.83,6.53,"developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CALB1","ENSG00000104327","","Amyloid fiber formation","Endocrine and other factor-regulated calcium reabsorption",110.6,116.1,97.2,84.9,78.4,79.4,1.3345694272764728,0.4163743596440526,0.01051809823226657,1.9780627774727326,0.08405866018171687,1.0754175365328702,977]
["High","P06280","alpha-galactosidase A [OS=Homo sapiens]",25,8,30,8,429,48.7,5.6,70.75,"other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","GLA","ENSG00000102393","Degradation pathway of sphingolipids, including diseases; Ciliary landscape","Neutrophil degranulation; Glycosphingolipid metabolism","Galactose metabolism; Glycerolipid metabolism; Sphingolipid metabolism; Glycosphingolipid biosynthesis; Metabolic pathways; Lysosome",1025.7,1048.6,1091.8,982.8,958.3,966.8,1.0887925994704084,0.12272916598133948,0.014094673288442645,1.8509449865303,0.09826000806800016,1.0076232045418463,1120]
["High","P06733-1","alpha-enolase [OS=Homo sapiens]",81,35,836,30,434,47.1,7.39,1693.12,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","ENO1; HEL-S-17; LOC117800423","ENSAMEG00000029491; ENSG00000074800; ENSGGOG00000010357; ENSPPAG00000003541; ENSPPYG00000001920; ENSPTRG00000000109","Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis","Gluconeogenesis; Glycolysis; Manipulation of host energy metabolism","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway",30850.4,30536.4,30827.4,29514.5,29461,29842.7,1.038235406707184,0.05413359358390807,1.9318113259027998E-3,2.7140352920616135,0.03887521348620892,1.4103272129971853,388]
["High","P06748","Nucleophosmin [OS=Homo sapiens]",63,19,563,19,294,32.6,4.78,1527.79,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","cytosol;cytoskeleton;translational apparatus;nucleus;other cell component","enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function","NPM1","ENSG00000181163","","TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Nuclear events stimulated by ALK signaling in cancer; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation","",19224.2,18355.2,17712,18037,16185.3,16103.7,1.098664706116123,0.1357511673348018,0.09755211911731178,1.0107632920207814,0.28044438367745594,0.55215325297061,2716]
["High","P07093-1","Glia-derived nexin [OS=Homo sapiens]",14,4,10,4,398,44,9.29,19.88,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SERPINE2","ENSG00000135919","","Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Dissolution of Fibrin Clot","",275,306.8,289.3,247.7,237.6,267.6,1.15699296055253,0.21038008673853104,0.0364525307143149,1.4382723154362742,0.16080302814540723,0.7937057771394455,1770]
["High","P07355","Annexin A2 [OS=Homo sapiens]",69,30,235,30,339,38.6,7.75,501.76,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","ANXA2","ENSG00000182718","Gastrin signaling pathway; CCL18 signaling pathway; Prostaglandin synthesis and regulation","Smooth Muscle Contraction; Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Dissolution of Fibrin Clot","Salmonella infection",9681,9351.2,9495.6,8459.8,9124.8,8751.9,1.083203918516128,0.11530486301886356,0.027268783169162182,1.5643342414023031,0.13943330647335841,0.8556334738000889,1527]
["High","P07384","Calpain-1 catalytic subunit [OS=Homo sapiens]",54,34,124,33,714,81.8,5.67,250.54,"protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","CAPN1","ENSG00000014216","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease","Degradation of the extracellular matrix; Neutrophil degranulation; Formation of the cornified envelope; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Protein processing in endoplasmic reticulum; Apoptosis; Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis",5176.1,5113.9,5213.7,5104.8,5487,5287.8,0.976328119096199,-0.034562012427888054,0.3339341381120007,0.4763391807185929,0.5712878506526077,0.2431450118061345,4564]
["High","P07741-1","Adenine phosphoribosyltransferase [OS=Homo sapiens]",83,12,86,12,180,19.6,6.02,171.04,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","APRT","ENSG00000198931; ENSPPAG00000005769; ENSPTRG00000008466","","Neutrophil degranulation; Purine salvage","Purine metabolism; Metabolic pathways",3451.7,3279.1,3369,3094.6,3223.5,3149.4,1.0667863744388697,0.09327130325324871,0.027680064790609332,1.5578328976628528,0.14061544950232768,0.8519669605039625,1537]
["High","P07951-1","Tropomyosin beta chain [OS=Homo sapiens]",58,26,115,6,284,32.8,4.7,216.72,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","TPM2","ENSANAG00000037556; ENSCANG00000042880; ENSCATG00000041575; ENSCCAG00000023807; ENSG00000198467; ENSMFAG00000002090; ENSMLEG00000037634; ENSMMUG00000016321; ENSMNEG00000031621; ENSNLEG00000004274; ENSPANG00000025431; ENSPPAG00000030835; ENSPTRG00000024321; ENSRBIG00000029128; ENSRROG00000041510; ENSSBOG00000021703","Striated muscle contraction pathway","Striated Muscle Contraction; Smooth Muscle Contraction","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Hypertrophic cardiomyopathy; Dilated cardiomyopathy",1840.3,1555.8,1325.3,1440.2,1306.6,1380.8,1.1438608392286074,0.19391154620127504,0.26772644767979287,0.5723087243900516,0.5035914486831662,0.2979216531099357,4151]
["High","P08069","Insulin-like growth factor 1 receptor [OS=Homo sapiens]",9,10,16,9,1367,154.7,5.8,22.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;transporter activity;kinase activity;other molecular function","IGF1R","ENSG00000140443","MicroRNAs in cardiomyocyte hypertrophy; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Apoptosis; Focal adhesion; MECP2 and associated Rett syndrome; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Ebola virus infection in host; Ras signaling; Breast cancer pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Head and neck squamous cell carcinoma; Endochondral ossification; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Malignant pleural mesothelioma","Extra-nuclear estrogen signaling; IRS-related events triggered by IGF1R; Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R); SHC-related events triggered by IGF1R","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Oocyte meiosis; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Long-term depression; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Pathways in cancer; Transcriptional misregulation in cancer; Proteoglycans in cancer; Glioma; Prostate cancer; Melanoma; Breast cancer; Hepatocellular carcinoma",382.9,343.8,365.2,396.1,400.3,414.3,0.9018749483769721,-0.14900068786291779,0.034517792341216574,1.4619569882953891,0.15642189355787522,0.8057024610847822,1723]
["High","P08195","4F2 cell-surface antigen heavy chain [OS=Homo sapiens]",37,19,75,19,630,68,5.01,176.48,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","transporter activity;nucleic acid binding activity;other molecular function","SLC3A2","ENSG00000168003","mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; Proximal tubule transport; Malignant pleural mesothelioma","Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)","mTOR signaling pathway; Ferroptosis; Protein digestion and absorption",3365.3,3282.3,3382.3,3082.2,3158.6,3177.6,1.0649261020980212,0.09075332168522285,0.008656429987693774,2.0626611791500924,0.07804781217541916,1.1076392665088037,866]
["Medium","P08247","Synaptophysin [OS=Homo sapiens]",5,2,2,2,313,33.8,4.81,2.16,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SYP","ENSG00000102003","Synaptic vesicle pathway","Sensory processing of sound by inner hair cells of the cochlea","",93.3,91.4,98.1,78.9,80.6,77,1.1957716701902747,0.2579419365826412,2.3592095611265945E-3,2.6272334803951756,0.042542051393248154,1.3711815720899054,433]
["High","P08473","Neprilysin [OS=Homo sapiens]",11,6,8,6,750,85.5,5.73,9.23,"protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","MME","ENSG00000196549","Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Alzheimer's disease","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","Renin-angiotensin system; Hematopoietic cell lineage; Protein digestion and absorption; Alzheimer disease",159,151.1,154.2,163.9,174.4,152.4,0.9461993071122885,-0.07978399050156575,0.26265576824397685,0.5806130571147409,0.49825467406437585,0.3025486185465009,4116]
["High","P08621-1","U1 small nuclear ribonucleoprotein 70 kDa [OS=Homo sapiens]",50,20,154,20,437,51.5,9.94,380.18,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","SNRNP70; SNRP70","ENSCATG00000016149; ENSG00000104852; ENSGGOG00000008245; ENSMLEG00000030967; ENSPANG00000004068; ENSPPAG00000035067; ENSPTRG00000011277; ENSRROG00000033636","mRNA processing; mRNA Processing","mRNA Splicing - Major Pathway","Spliceosome",7127,6905,7031.5,6971.2,6801.5,7071.6,1.0105160643437294,0.015092256665512319,0.5122789638328927,0.2904934775784122,0.715413011913294,0.14544316517844968,5591]
["High","P08962","CD63 antigen [OS=Homo sapiens]",13,4,35,4,238,25.6,7.81,62.36,"cell adhesion;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","","CD63","ENSG00000135404","Extracellular vesicles in the crosstalk of cardiac cells","Neutrophil degranulation; Platelet degranulation","Lysosome; Proteoglycans in cancer",2085,2018.7,1973.9,1857.6,1789.7,1866.2,1.1023125056679062,0.14053328603542442,0.00957569771741109,2.0188295720557408,0.0810922427088349,1.0910206884507347,922]
["High","P09001","39S ribosomal protein L3, mitochondrial [OS=Homo sapiens]",30,7,22,7,348,38.6,9.48,40.19,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL3","ENSG00000114686","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",976.5,979.2,962.6,930.7,902.5,949.9,1.0485789227839462,0.06843545201526909,0.03740543296146769,1.4270653140074328,0.16298081504639494,0.7878635146749038,1792]
["Medium","P09382","Galectin-1 [OS=Homo sapiens]",6,1,1,1,135,14.7,5.5,2.09,"stress response;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LGALS1","ENSG00000100097","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",61,50.3,63.1,63.4,52.3,39.8,1.1215434083601286,0.1654854597589614,0.46906017615595236,0.3287714376772148,0.6831602043323403,0.16547744024388605,5361]
["High","P09496-2","Isoform Non-brain of Clathrin light chain A [OS=Homo sapiens]",24,5,11,5,218,23.6,4.53,24.57,"","","","CLTA","","","","",455,416.7,376.1,770.5,422.4,359.8,0.8036323823017969,-0.3153923963649908,0.47728274307411783,0.32122426796598536,0.689477087497264,0.1614801615966791,5405]
["High","P09525","annexin A4 [OS=Homo sapiens]",44,13,29,12,319,35.9,6.13,41.2,"signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","enzyme regulator activity;other molecular function","ANXA4","ENSG00000196975","Prostaglandin synthesis and regulation","","",575.4,583.5,620.2,616.9,647.6,634,0.9371082433500132,-0.09371239478843928,0.07219113929917641,1.1415161042257063,0.23803564849998707,0.6233579976179532,2368]
["High","P09884","DNA polymerase alpha catalytic subunit [OS=Homo sapiens]",26,30,71,30,1462,165.8,5.85,155.47,"cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLA1","ENSG00000101868","Retinoblastoma gene in cancer; Pyrimidine metabolism; Nucleotide metabolism; DNA replication","Defective pyroptosis; Activation of the pre-replicative complex; G1/S-Specific Transcription; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate","DNA replication",3279.3,3382.3,3394.4,3465,3334.6,3398.4,0.9860757011178662,-0.020229688208051544,0.41783035165798393,0.3790000155792478,0.6418295073274717,0.19258032062331598,5083]
["Medium","P09958","Furin [OS=Homo sapiens]",1,1,1,1,794,86.6,6.47,2.67,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","FURIN","ENSG00000140564","SARS-CoV-2 altering angiogenesis via NRP1","Potential therapeutics for SARS; Formation of the cornified envelope; Amyloid fiber formation; Collagen degradation; Signaling by PDGF; Signaling by NODAL; Pre-NOTCH Processing in Golgi; Uptake and function of anthrax toxins; Attachment and Entry; Assembly of active LPL and LIPC lipase complexes; Activation of Matrix Metalloproteinases; TGF-beta receptor signaling activates SMADs; Removal of aminoterminal propeptides from gamma-carboxylated proteins; NGF processing; Synthesis and processing of ENV and VPU; Elastic fibre formation; CD163 mediating an anti-inflammatory response","",73,66.2,70.9,81.9,73.3,73.4,0.9190726159230096,-0.12174924154143232,0.15177736348165743,0.8187929955556563,0.364863809749009,0.4378692114661586,3248]
["High","P0CG38","POTE ankyrin domain family member I [OS=Homo sapiens]",11,10,241,1,1075,121.2,6.21,501.86,"","","","POTEI","ENSG00000196834","","","",967.5,993.9,969.5,780.5,753.4,819.7,1.2452838205302514,0.316474593543076,7.9218015069006207E-4,3.101176043721393,0.026776374963584437,1.5722482189549016,231]
["High","P10070-1","Isoform 1 of Zinc finger protein GLI2 [OS=Homo sapiens]",5,4,5,2,1258,133.2,7.14,12.6,"","","","GLI2","","","","",98.5,115.1,104.9,116.4,109.3,122.1,0.9157561817136286,-0.1269645601629243,0.1839661211608004,0.7352621484449704,0.40519251735501544,0.3923385833054203,3545]
["High","P10109","Adrenodoxin, mitochondrial [OS=Homo sapiens]",16,2,10,2,184,19.4,5.83,18.72,"other metabolic processes;other biological processes","mitochondrion","other molecular function","FDX1","ENSG00000137714","","Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin","",184.7,165.1,162.9,155.6,118,132.1,1.263741681045107,0.3377015951910224,0.051403807537336005,1.2890047111367975,0.19771474347365492,0.703960944391375,2030]
["High","P10398-1","serine/threonine-protein kinase A-Raf [OS=Homo sapiens]",21,10,14,7,606,67.5,9.01,21.9,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","ARAF","ENSG00000078061; ENSGGOG00000008695; ENSPPAG00000015632; ENSPTRG00000021846","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Common pathways underlying drug addiction; Bladder cancer; MAPK signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Alzheimer's disease; ErbB signaling pathway","Signaling by BRAF and RAF1 fusions; RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; FoxO signaling pathway; Vascular smooth muscle contraction; Natural killer cell mediated cytotoxicity; Long-term potentiation; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Parathyroid hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Pathways in cancer; Proteoglycans in cancer; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer",918.5,903.4,935.3,874,986.1,919.6,0.9919056013238838,-0.011725267603998422,0.8353904695749035,0.07811048362517008,0.9185648199466055,0.03689019161527989,7101]
["High","P10620","Microsomal glutathione S-transferase 1 [OS=Homo sapiens]",23,3,16,3,155,17.6,9.39,26.69,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGST1","ENSG00000008394","Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Oxidative stress response; Metapathway biotransformation Phase I and II","Neutrophil degranulation; Aflatoxin activation and detoxification; Glutathione conjugation","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",943.5,810.1,894.3,719,951.3,847.2,1.0517974180734855,0.07285686044317642,0.6055104944632075,0.2178783254392356,0.7788840100113219,0.1085272118558578,6070]
["High","P10809","60 kDa heat shock protein, mitochondrial [OS=Homo sapiens]",83,51,1952,51,573,61,5.87,4312.07,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","HSPD1","ENSG00000144381","Apoptosis-related network due to altered Notch3 in ovarian cancer; Sudden infant death syndrome (SIDS) susceptibility pathways","Mitochondrial protein import; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation","RNA degradation; Type I diabetes mellitus; Legionellosis; Tuberculosis; Lipid and atherosclerosis",43716.4,43441.3,43931.3,43167.6,42084,43298.2,1.0197526561690489,0.028219264950415324,0.10798448195577044,0.9666386508575191,0.2958395912668967,0.528943706207394,2850]
["High","P11137","microtubule-associated protein 2 [OS=Homo sapiens]",8,10,19,3,1827,199.4,4.91,47.97,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAP2","ENSG00000078018","Melatonin metabolism and effects; MAPK cascade; Sudden infant death syndrome (SIDS) susceptibility pathways","","",582.4,652.4,606.4,589.8,485,510.4,1.1614938178147867,0.2159814752559024,0.08609944569354729,1.0649996445162477,0.2635297812525352,0.5791702984674024,2551]
["High","P11177","Pyruvate dehydrogenase E1 component subunit beta, mitochondrial [OS=Homo sapiens]",48,13,113,13,359,39.2,6.65,231.16,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","PDHB","ENSG00000168291","Metabolic reprogramming in colon cancer; Orexin receptor pathway","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Glycolysis / Gluconeogenesis; Citrate cycle (TCA cycle); Pyruvate metabolism; Metabolic pathways; Carbon metabolism; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer; Diabetic cardiomyopathy",5137.8,5066.2,5155.4,4988.3,5217.8,5191.9,0.9974931809325887,-3.6211160770550917E-3,0.8762358858649804,0.057378964449334206,0.9406915711307254,0.026552747362133085,7273]
["High","P11233","Ras-related protein Ral-A [OS=Homo sapiens]",42,9,54,5,206,23.6,7.11,136.81,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","RALA","ENSG00000006451","RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; p38MAPK events","Ras signaling pathway; Rap1 signaling pathway; Phospholipase D signaling pathway; Salmonella infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer",2077.7,2008.5,2023.5,1882.5,1974.8,1892.3,1.0626304438569638,0.08763995104266907,0.029076961542406948,1.5364509779474622,0.144514904979703,0.8400873583288001,1571]
["High","P11441","Ubiquitin-like protein 4A [OS=Homo sapiens]",29,4,8,4,157,17.8,8.66,12.29,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;cytosol;nucleus;other cell component","other molecular function","UBL4A","ENSG00000102178","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",215.5,186,147.7,217.1,168.5,170.4,0.9877697841726619,-0.01775325746376907,0.9327986503695345,0.030212090948577235,0.9682653366239464,0.01400561537632215,7522]
["High","P11717","Cation-independent mannose-6-phosphate receptor [OS=Homo sapiens]",25,50,104,50,2491,274.2,5.94,235.02,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","IGF2R","ENSG00000197081","","Retrograde transport at the Trans-Golgi-Network; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis","Lysosome; Endocytosis",4046.4,3987.3,4021.9,4083,4154.2,4149.4,0.9732775741527134,-0.03907678140794794,0.018320073551246166,1.737072787063571,0.1128100428139827,0.9476522359506495,1268]
["High","P12036","Neurofilament heavy polypeptide [OS=Homo sapiens]",4,4,11,2,1026,112.4,6.18,23.38,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","NEFH","ENSG00000100285","Amyotrophic lateral sclerosis (ALS); Physico-chemical features and toxicity-associated pathways","","Amyotrophic lateral sclerosis; Pathways of neurodegeneration",37.9,38.1,34.3,22.3,36.1,28.3,1.2722029988465973,0.3473288923695474,0.13307663669236938,0.8758981837906122,0.3375771212781092,0.4716269946274368,3078]
["High","P12259","Coagulation factor V [OS=Homo sapiens]",0,1,2,1,2224,251.5,6.05,4.92,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","F5","ENSG00000198734","Blood clotting cascade; Complement and coagulation cascades","COPII-mediated vesicle transport; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Platelet degranulation ; Cargo concentration in the ER; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",102.9,86.7,118.9,76.1,78.2,97.1,1.2271280827366746,0.29528583961627247,0.1716491566551659,0.7653583260040775,0.3889253091014322,0.4101337944574518,3446]
["High","P12277","Creatine kinase B-type [OS=Homo sapiens]",77,19,172,18,381,42.6,5.59,440.14,"other metabolic processes;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","kinase activity;other molecular function","CKB","ENSG00000166165","","RND3 GTPase cycle; Creatine metabolism","Arginine and proline metabolism; Metabolic pathways",4690.9,4540.3,4517.7,4093.3,3876.7,3861.7,1.1620392673918374,0.2166588208201478,2.3011968994137563E-3,2.6380462198057613,0.042177806081273736,1.3749160142498447,426]
["High","P12955","xaa-Pro dipeptidase [OS=Homo sapiens]",33,15,47,15,493,54.5,6,105.32,"protein metabolism;other metabolic processes","","other molecular function","PEPD","ENSG00000124299","","","",1624.1,1586.1,1670.6,1510.9,1519.6,1505.4,1.076037831521859,0.10572880130486151,0.009739540921766501,2.0114615133310685,0.08142005944020647,1.0892685849025263,934]
["Medium","P13056-1","Nuclear receptor subfamily 2 group C member 1 [OS=Homo sapiens]",1,1,1,1,603,67.3,6.32,1.83,"signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NR2C1","ENSG00000120798","","Nuclear Receptor transcription pathway; SUMOylation of intracellular receptors","",21.8,22.8,28.2,36,28.8,27.8,0.7861771058315336,-0.34707374306154,0.11284649399611496,0.9475119293801387,0.30257741247309944,0.519163495362503,2912]
["High","P13533","myosin-6 [OS=Homo sapiens]",3,5,14,3,1939,223.6,5.73,30.89,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYH6","ENSG00000197616","Cardiac progenitor differentiation; Striated muscle contraction pathway; Acute viral myocarditis; IL-18 signaling pathway","Striated Muscle Contraction","cGMP-PKG signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Thyroid hormone signaling pathway; Hypertrophic cardiomyopathy; Dilated cardiomyopathy; Viral myocarditis",131.8,133.9,90.1,119.6,91.3,109,1.1122225695529857,0.15344551815148655,0.5079541217653424,0.29417551126710134,0.7124314321436669,0.14725692791540432,5567]
["Medium","P13682","Zinc finger protein 35 [OS=Homo sapiens]",2,1,1,1,527,59.1,8.09,0,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF35","ENSG00000169981; ENSG00000281306","","","",45.1,35.3,34.7,29.8,42.9,42.2,1.001740644038294,2.5090354861170678E-3,0.9907895114845713,4.0185995109928855E-3,0.9958914142213611,1.7880117523059215E-3,7768]
["Medium","P13726-1","tissue factor [OS=Homo sapiens]",5,2,4,1,295,33,7.03,7.18,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","F3","ENSG00000117525","Blood clotting cascade; VEGFA-VEGFR2 signaling pathway; Macrophage markers; STING pathway in Kawasaki-like disease and COVID-19; Complement and coagulation cascades","NGF-stimulated transcription; Extrinsic Pathway of Fibrin Clot Formation","Complement and coagulation cascades; AGE-RAGE signaling pathway in diabetic complications",164.6,179.2,179.3,159.9,165.1,169.8,1.057194826192401,0.08024126970162639,0.17083888803405273,0.7674132639968325,0.38844206108616297,0.4106737501630949,3434]
["High","P13984","General transcription factor IIF subunit 2 [OS=Homo sapiens]",58,13,28,13,249,28.4,9.23,46.49,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","GTF2F2","ENSG00000188342","Eukaryotic transcription initiation","Estrogen-dependent gene expression; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","Basal transcription factors",1472.1,1438.9,1351.6,1467.3,1285.8,1438.4,1.0169629011093881,0.024267050521128996,0.7406433208036522,0.13039088932175752,0.8633835546185304,0.06379622786697016,6698]
["Medium","P14415","sodium/potassium-transporting ATPase subunit beta-2 [OS=Homo sapiens]",3,1,1,1,290,33.3,8.31,2.01,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ATP1B2","ENSG00000129244","Calcium regulation in cardiac cells","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS; Basigin interactions","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption",46.3,31.3,38.2,30.3,32.2,32.2,1.2228088701161564,0.2901989225208517,0.18365488240748848,0.7359975215825302,0.4049639429081248,0.3925836436820059,3541]
["High","P14550","alcohol dehydrogenase [NADP(+)] [OS=Homo sapiens]",66,20,102,19,325,36.6,6.79,241.94,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","AKR1A1","ENSG00000117448","Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II","Glutathione conjugation; Formation of xylulose-5-phosphate","Glycolysis / Gluconeogenesis; Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Glycerolipid metabolism; Pyruvate metabolism; Metabolic pathways; Biosynthesis of cofactors; Chemical carcinogenesis",4536.6,4491.1,4510.9,4178,4172.4,4018.9,1.0945324310995774,0.13031470234284706,1.9217985576315915E-3,2.7162921369036614,0.038874101393749916,1.410339636916781,386]
["High","P14859-1","POU domain, class 2, transcription factor 1 [OS=Homo sapiens]",15,8,23,8,743,76.4,6.81,50.59,"other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","POU2F1","ENSG00000143190","Integrated cancer pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling","Herpes simplex virus 1 infection; Lipid and atherosclerosis",603,627.8,603.9,647.5,615.5,644.7,0.9617340252660271,-0.05629013382883336,0.13596342151273194,0.8665779149524507,0.34212130040973604,0.4658198858779811,3103]
["High","P14868","Aspartate--tRNA ligase, cytoplasmic [OS=Homo sapiens]",65,29,143,29,501,57.1,6.55,308.42,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","DARS1","ENSG00000115866","Alanine and aspartate metabolism","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",6746.6,6829,6927.4,6693.7,7382.6,7153.3,0.9657742020575046,-0.0502421684039149,0.3113341137843342,0.5067732898006883,0.5476226087920886,0.2615186301674195,4439]
["High","P15260","Interferon gamma receptor 1 [OS=Homo sapiens]",4,2,3,2,489,54.4,4.91,3.74,"stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","IFNGR1","ENSG00000027697","Immune response to tuberculosis; Selective expression of chemokine receptors during T-cell polarization; Overview of interferons-mediated signaling pathway; Neuroinflammation and glutamatergic signaling; Type II interferon signaling (IFNG)","Potential therapeutics for SARS; Regulation of IFNG signaling","Cytokine-cytokine receptor interaction; HIF-1 signaling pathway; Necroptosis; Osteoclast differentiation; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Th1 and Th2 cell differentiation; Th17 cell differentiation; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Inflammatory bowel disease",93.4,92.5,86.6,87.7,66,80.8,1.162046908315565,0.216668307148912,0.1336864729729349,0.8739125344763589,0.3387938919093397,0.4700644281346641,3081]
["High","P15559-1","NAD(P)H dehydrogenase [quinone] 1 [OS=Homo sapiens]",31,7,15,7,274,30.8,8.88,40.65,"cell-cell signaling;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","NQO1","ENSG00000181019; ENSGGOG00000003294; ENSPTRG00000008284","Dopamine metabolism; Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Interactions between LOXL4 and oxidative stress pathway; Benzene metabolism; Oxidative stress response; NRF2-ARE regulation; Male infertility; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Estrogen metabolism","Regulation of ornithine decarboxylase (ODC)","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Pathways in cancer; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",868.1,915.7,910.1,857.9,982.1,871.1,0.9936557117037366,-0.00918203088467546,0.8983791309625327,0.046540345140501795,0.9521574934919853,0.021291210336750514,7367]
["High","P16050","arachidonate 15-lipoxygenase [OS=Homo sapiens]",3,2,2,2,662,74.8,6.58,4.95,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","ALOX15","ENSG00000161905","Eicosanoid synthesis; Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence","Interleukin-4 and Interleukin-13 signaling; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of E-series 18(R)-resolvins; Biosynthesis of DPAn-3-derived protectins and resolvins; Biosynthesis of DPAn-6 SPMs","Arachidonic acid metabolism; Linoleic acid metabolism; Metabolic pathways; Ferroptosis; Necroptosis; Serotonergic synapse",123.2,134,154.2,133.3,129.9,110.6,1.100588550026752,0.13827522477977558,0.33743923822059085,0.4718044180365686,0.5747656134437987,0.24050922233726676,4584]
["High","P16083","Ribosyldihydronicotinamide dehydrogenase [quinone] [OS=Homo sapiens]",55,9,27,9,231,25.9,6.29,54.3,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","NQO2","ENSG00000124588","Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling","Phase I - Functionalization of compounds","",1195.3,1147.4,1129.3,1133.6,1107.4,1125.1,1.031460740916788,0.04468891093595316,0.1703975740755771,0.7685365925099882,0.38777739970332437,0.4114175059075261,3431]
["High","P16383-1","GC-rich sequence DNA-binding factor 2 [OS=Homo sapiens]",19,11,17,11,781,89.3,5.99,39.09,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity","GCFC2","ENSG00000005436","","mRNA Splicing - Major Pathway","",573.5,562.8,546.8,706.2,596.4,648.3,0.8627300220411093,-0.21301893386021753,0.05221327445074522,1.2822190700281724,0.19886890093239937,0.7014331264252912,2050]
["High","P16435","NADPH--cytochrome P450 reductase [OS=Homo sapiens]",55,33,95,33,677,76.6,5.58,193.45,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","POR","ENSG00000127948","Oxidation by cytochrome P450; Ferroptosis","Cytochrome P450 - arranged by substrate type","",4153.2,4227.9,4209.4,3688.7,4023.7,3925.7,1.081834663733771,0.11348002962901955,0.03573244439050907,1.4469372734981385,0.15961036945142726,0.7969388971378872,1748]
["High","P16989-1","Y-box-binding protein 3 [OS=Homo sapiens]",66,17,93,12,372,40.1,9.77,253.02,"stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CSDA; YBX3","ENSG00000060138","RalA downstream regulated genes; Apoptosis-related network due to altered Notch3 in ovarian cancer","","Tight junction",2062.7,2126,2019.8,2427.9,2222.2,2254.6,0.899170130490825,-0.15333398338156887,0.030717853674429405,1.5126091327133182,0.14869497922501226,0.8277036954436443,1613]
["High","P17081","Rho-related GTP-binding protein RhoQ [OS=Homo sapiens]",9,2,16,1,205,22.6,6.32,40.42,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","other molecular function","RHOQ","ENSG00000119729","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling","RHOQ GTPase cycle; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases regulate CFTR trafficking","Insulin signaling pathway",35,40.8,29.8,44.2,28.6,40.6,0.931216931216931,-0.10281080558377566,0.6712276711980769,0.1731301481255408,0.8213361004097453,0.08547908808929684,6381]
["High","P17096-2","Isoform HMG-Y of High mobility group protein HMG-I/HMG-Y [OS=Homo sapiens]",49,5,11,1,96,10.7,10.32,23.63,"","","","HMGA1","","","","",525.7,575.3,571.7,646.9,577,463.2,0.991464643471045,-0.012366769330348273,0.9356550542883173,0.028884232063635343,0.9700696672265544,0.013197075006343444,7531]
["High","P17600-2","Isoform IB of Synapsin-1 [OS=Homo sapiens]",24,11,19,11,669,70,9.88,29.56,"","","","SYN1","","","","",404.4,445.7,413.2,369.8,372.7,368.1,1.137493246893571,0.1858579802985199,0.015737328136165893,1.8030689996909024,0.10360628843775994,0.9846138840605108,1186]
["High","P17844","probable ATP-dependent RNA helicase DDX5 [OS=Homo sapiens]",56,38,292,29,614,69.1,8.92,601.5,"RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX5","ENSG00000108654","Ciliary landscape","Estrogen-dependent gene expression; mRNA Splicing - Major Pathway; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome; SUMOylation of transcription cofactors","Spliceosome; Transcriptional misregulation in cancer; Proteoglycans in cancer",12321.6,12753.5,12772.2,13380.2,14092.3,14029.1,0.9119479730901943,-0.13297657434142127,0.010867471372897355,1.9638714951545246,0.08510854210590026,1.0700268488075448,997]
["High","P17858-1","ATP-dependent 6-phosphofructokinase, liver type [OS=Homo sapiens]",44,26,65,22,780,85,7.5,161.78,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;other cell component","kinase activity;other molecular function","PFKL","ENSG00000141959; ENSPTRG00000022972","Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Insulin signaling; Glycolysis and gluconeogenesis","Neutrophil degranulation; Glycolysis","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Galactose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway; AMPK signaling pathway; Thyroid hormone signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer",3115.1,3170.3,3169.1,2956.6,3303.1,3017.5,1.0191113698098564,0.02731171970078853,0.614422007833873,0.21153323680852368,0.7847876717105972,0.10524782793966854,6113]
["High","P18085","ADP-ribosylation factor 4 [OS=Homo sapiens]",79,10,76,6,180,20.5,7.14,177.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARF4","ENSG00000168374","VEGFA-VEGFR2 signaling pathway","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; VxPx cargo-targeting to cilium","Endocytosis",1920.2,1857.8,1965.6,1607.9,1892.5,1693.3,1.1058782756031347,0.14519259637899476,0.1111408058324147,0.9541264586636294,0.30058448629701906,0.5220334378857145,2887]
["High","P18583-5","Isoform D of Protein SON [OS=Homo sapiens]",23,38,165,8,2459,266.9,5.73,368.2,"","","","SON","","","","",5307.7,5625.6,5503.2,5832.7,5505.7,5583.1,0.9713382383358449,-0.04195433807000187,0.2981209357471922,0.525607524268554,0.5356024542830364,0.27115744159442434,4346]
["High","P18669","Phosphoglycerate mutase 1 [OS=Homo sapiens]",81,19,241,19,254,28.8,7.18,546.26,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","PGAM1","ENSG00000171314","Cori cycle; Metabolic reprogramming in colon cancer; Glycolysis and gluconeogenesis","Neutrophil degranulation; Glycolysis; Gluconeogenesis","Glycolysis / Gluconeogenesis; Glycine, serine and threonine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Glucagon signaling pathway; Central carbon metabolism in cancer",10304.6,9747.3,9721,9879.3,9036.1,9443.6,1.0498571881942242,0.07019309179929692,0.2018982799891247,0.6948673808801042,0.42756218338895735,0.36900071382758537,3687]
["High","P19012","Keratin, type I cytoskeletal 15 [OS=Homo sapiens]",12,8,31,1,456,49.2,4.77,73.53,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","KRT15","ENSG00000171346","","Formation of the cornified envelope","Estrogen signaling pathway; Staphylococcus aureus infection",40.9,33.2,31.5,32.5,37.6,33,1.0242483026188165,0.034565501990344805,0.8139752029928706,0.08938882529187897,0.9061189599327536,0.04281478217872732,7014]
["High","P19086","guanine nucleotide-binding protein G(z) subunit alpha [OS=Homo sapiens]",4,1,1,1,355,40.9,7.61,3.2,"signal transduction","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus","signal transduction activity or receptor binding;other molecular function","GNAZ","ENSG00000128266","Corticotropin-releasing hormone signaling pathway; G protein signaling pathways; Purinergic signaling; Calcium regulation in cardiac cells","G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; ADORA2B mediated anti-inflammatory cytokines production","Long-term depression",25.9,33.5,32.9,20.7,29.7,29.8,{"$f":"AVERAGE(T1474:V1474)/AVERAGE(W1474:Y1474)","v":1.1508728179551122},{"$f":"LOG(Z1474,2)","v":0.2027284111908539},{"$f":"TTEST(T1474:V1474,W1474:Y1474,2,2)","v":0.35723690473445097},{"$f":"-LOG10(AB1474)","v":0.44704368221733887},{"$f":"AB1474*7808/AF1474","v":0.5932168762583142},{"$f":"-LOG10(AD1474)","v":0.22678650234762399},4702]
["High","P19367-1","Hexokinase-1 [OS=Homo sapiens]",46,39,161,36,917,102.4,6.8,376.43,"other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion","kinase activity;other molecular function","HK1","ENSG00000156515","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Glycolysis and gluconeogenesis; Glucuronidation","Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)","Glycolysis / Gluconeogenesis; Fructose and mannose metabolism; Galactose metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Neomycin, kanamycin and gentamicin biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of nucleotide sugars; HIF-1 signaling pathway; Insulin signaling pathway; Type II diabetes mellitus; Carbohydrate digestion and absorption; Shigellosis; Central carbon metabolism in cancer",7836.5,8190.7,8141.8,7989.1,8780.4,8633.2,0.9514342963543244,-0.07182406381812205,0.1984319071715805,0.7023884935003734,0.4228592606975165,0.3738041538375507,3664]
["High","P19793","retinoic acid receptor RXR-alpha [OS=Homo sapiens]",11,4,5,4,462,50.8,7.8,7.86,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RXRA","ENSG00000186350","Vitamin D metabolism; Energy metabolism; Nuclear receptors; Adipogenesis; Liver X receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Vitamin D receptor pathway; PPAR-alpha pathway; Farnesoid X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Prion disease pathway; PI3K/AKT/mTOR - VitD3 signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Vitamins A and D - action mechanisms; Nonalcoholic fatty liver disease; Vitamin D in inflammatory diseases; Small cell lung cancer; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Vitamin A and carotenoid metabolism","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Regulation of pyruvate dehydrogenase (PDH) complex; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; SUMOylation of intracellular receptors; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Endogenous sterols; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Signaling by Retinoic Acid; Nuclear Receptor transcription pathway; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Recycling of bile acids and salts; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; Transcriptional regulation of granulopoiesis; RORA activates gene expression; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis","PPAR signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation; Thyroid hormone signaling pathway; Adipocytokine signaling pathway; Parathyroid hormone synthesis, secretion and action; Non-alcoholic fatty liver disease; Bile secretion; Hepatitis C; Pathways in cancer; Transcriptional misregulation in cancer; Chemical carcinogenesis; Thyroid cancer; Small cell lung cancer; Non-small cell lung cancer; Gastric cancer; Lipid and atherosclerosis",147.7,155.5,128.6,166.2,179,182.2,0.8187334091770951,-0.28853432784205507,0.027226970837222832,1.5650006738218978,0.13949356187469547,0.855445836166844,1524]
["High","P20073-1","Annexin A7 [OS=Homo sapiens]",36,16,55,16,488,52.7,5.68,88.88,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ANXA7","ENSG00000138279","","","Amyotrophic lateral sclerosis",1845,1878.5,1874.6,1712.9,1877,1756.7,1.0470392398907717,0.06631551116556879,0.1701416931140645,0.7691892497582427,0.38753393810811426,0.4116902583507677,3428]
["High","P20337","Ras-related protein Rab-3B [OS=Homo sapiens]",48,8,31,6,219,24.7,5.02,55.97,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3B","ENSG00000169213","Intracellular trafficking proteins involved in CMT neuropathy","RAB geranylgeranylation","",811.4,804.8,792.2,818.4,927.2,886.7,0.9149413060821332,-0.12824889809202336,0.08161169248274386,1.0882476155481284,0.2554004388397852,0.5927783608489018,2495]
["High","P20340-2","Isoform 2 of Ras-related protein Rab-6A [OS=Homo sapiens]",53,14,46,10,208,23.5,5.54,85.21,"","","","RAB6A","","","","",3972.5,3734.2,3641.1,3454.7,4103,3765.6,1.0021636801992353,0.003118158559700054,0.9710651657102958,0.01275162471736912,0.9859657755352392,0.006138159860164743,7690]
["High","P20936-1","ras GTPase-activating protein 1 [OS=Homo sapiens]",10,8,17,8,1047,116.3,6.54,37.16,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RASA1","ENSG00000145715","PDGF pathway; T cell receptor and co-stimulatory signaling; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; EPO receptor signaling","Regulation of RAS by GAPs; VEGFR2 mediated cell proliferation; EPHB-mediated forward signaling; Downstream signal transduction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases","MAPK signaling pathway; Ras signaling pathway; Axon guidance",565.4,560.1,553.2,553.1,540.2,550.5,1.0212312933446892,0.030309651691862883,0.09276330181206262,1.032623801504095,0.2739394328852439,0.5623454476590622,2644]
["High","P21283","V-type proton ATPase subunit C 1 [OS=Homo sapiens]",37,14,26,14,382,43.9,7.46,50.96,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity","ATP6V1C1","ENSG00000155097","Proximal tubule transport","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",1734.8,1765.6,1700.7,1677,1686.1,1693.7,1.028535832937826,0.040592056479452326,0.06783380590675181,1.1685538155764132,0.2286901366666313,0.6407525659731765,2316]
["High","P21709","Ephrin type-A receptor 1 [OS=Homo sapiens]",13,9,18,9,976,108.1,6.64,29.06,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","EPHA1","ENSG00000146904; ENSG00000284816","","EPHA-mediated growth cone collapse; EPH-ephrin mediated repulsion of cells; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","Axon guidance",1078.1,1064.9,1108.9,1169.3,1204.4,1237.1,0.9006037443225879,-0.15103561909035002,7.048381455500758E-3,2.1519106001215254,0.07064667831136061,1.1509082531354546,779]
["High","P21926","CD9 antigen [OS=Homo sapiens]",30,8,35,8,228,25.4,7.15,61.17,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","CD9","ENSG00000010278","Vitamin D receptor pathway","Platelet degranulation ; Uptake and function of diphtheria toxin; Acrosome Reaction and Sperm:Oocyte Membrane Binding","Hematopoietic cell lineage",1618.2,1541.9,1549.2,1847.8,1773.9,1827.6,0.8642027416365405,-0.21055828708032795,1.6775570553790033E-3,2.7753227001217824,0.036896804192673965,1.433011248518241,355]
["High","P22087","rRNA 2'-O-methyltransferase fibrillarin [OS=Homo sapiens]",53,19,122,16,321,33.8,10.18,265.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","FBL","ENSG00000105202; ENSG00000280548","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",5690,5382.2,5408.5,5179.4,5688.8,5685.7,0.9955780812980626,-0.006393626672352112,0.9068675890091367,0.042456119291201695,0.9558345214610339,0.019617288306444224,7408]
["High","P22307-1","Non-specific lipid-transfer protein [OS=Homo sapiens]",30,13,48,13,547,59,6.89,87.75,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","SCP2","ENSG00000116171","PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; DNA damage response (only ATM dependent)","TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism","Primary bile acid biosynthesis; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome",2153,1919.1,1732.9,2093,1924.5,1869.9,0.9860040085606551,-0.02033458305210391,0.8528320755428461,0.06913647392573874,0.9283302447844057,0.03229750010254057,7173]
["High","P22626","heterogeneous nuclear ribonucleoproteins A2/B1 [OS=Homo sapiens]",91,30,462,27,353,37.4,8.95,1127.2,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPA2B1","ENSG00000122566","mRNA processing","mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Processing of Capped Intron-Containing Pre-mRNA","Amyotrophic lateral sclerosis",22423.2,21122.8,21440,22637.4,22507.7,23059.2,0.9528138255212648,-0.06973374773670463,0.06522881927984121,1.1855604826593393,0.2235762163902547,0.6505743977437854,2278]
["High","P23142","Fibulin-1 [OS=Homo sapiens]",15,8,12,8,703,77.2,5.22,29.01,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;extracellular matrix","signal transduction activity or receptor binding;enzyme regulator activity;extracellular structural activity;other molecular function","FBLN1","ENSG00000077942","","Molecules associated with elastic fibres","",270.8,231.7,238.5,237.6,250.1,258.9,0.992499330297348,-0.010861966109873522,0.8970989659779209,0.04715964390432507,0.9522225022234376,0.021261559811729502,7356]
["High","P23368-1","NAD-dependent malic enzyme, mitochondrial [OS=Homo sapiens]",41,14,61,14,584,65.4,7.61,109.36,"other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","ME2","ENSG00000082212","TCA cycle in senescence","Citric acid cycle (TCA cycle)","Pyruvate metabolism; Carbon metabolism",1533.6,1509.5,1578.6,1553.6,1693.5,1631.1,0.9474191300069698,-0.07792529220222083,0.13181260669960443,0.8800430513638112,0.335241965182577,0.47464162218236233,3070]
["High","P23458","Tyrosine-protein kinase JAK1 [OS=Homo sapiens]",4,4,6,4,1154,133.2,7.55,12.61,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK1","ENSG00000162434","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-17 signaling pathway; Type III interferon signaling; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Overview of interferons-mediated signaling pathway; Measles virus infection; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; TGF-beta receptor signaling in skeletal dysplasias; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; IL-2 signaling pathway; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; Malignant pleural mesothelioma; TGF-beta receptor signaling; Interferon type I signaling pathways; Type II interferon signaling (IFNG)","Potential therapeutics for SARS; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Interleukin-4 and Interleukin-13 signaling; Interleukin-6 signaling; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; IL-6-type cytokine receptor ligand interactions; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-27 signaling; ISG15 antiviral mechanism; Interleukin-10 signaling; Interleukin-7 signaling; Regulation of IFNA signaling; Interleukin-2 signaling; Other interleukin signaling; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling","EGFR tyrosine kinase inhibitor resistance; PI3K-Akt signaling pathway; Necroptosis; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; NOD-like receptor signaling pathway; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Pancreatic cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer",160,163.6,165.1,146.6,144.7,162,1.0780939774983456,0.10848294336068877,0.1064474209897199,0.9728648561937339,0.29400122500450404,0.531650860024618,2827]
["High","P23511","Nuclear transcription factor Y subunit alpha [OS=Homo sapiens]",5,1,7,1,347,36.9,8.94,6.86,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFYA","ENSG00000001167","Sterol regulatory element-binding proteins (SREBP) signaling; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways","ATF4 activates genes in response to endoplasmic reticulum  stress; PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF6 (ATF6-alpha) activates chaperone genes","Antigen processing and presentation; Spinocerebellar ataxia; Tuberculosis",107.5,102.5,99.5,98.9,93.4,93.2,1.084063047285464,0.1164486638514217,0.055414624206565996,1.2563756075805743,0.20722097021305905,0.6835662972521633,2088]
["High","P24385","G1/S-specific cyclin-D1 [OS=Homo sapiens]",16,3,3,2,295,33.7,5.02,9.57,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCND1","ENSG00000110092","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Leptin signaling pathway; IL-7 signaling pathway; Glioblastoma signaling pathways; Spinal cord injury; Retinoblastoma gene in cancer; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Mammary gland development pathway - Puberty (Stage 2 of 4); Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Bladder cancer; Mesodermal commitment pathway; Vitamin D receptor pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; Focal adhesion; Copper homeostasis; Photodynamic therapy-induced NF-kB survival signaling; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; Non-small cell lung cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Wnt signaling; Acute viral myocarditis; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; G1 to S cell cycle control; Hippo-Merlin signaling dysregulation; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Melanoma; FGF23 signaling in hypophosphatemic rickets and related disorders; EGFR tyrosine kinase inhibitor resistance; Influence of laminopathies on Wnt signaling; Development of ureteric collection system; Malignant pleural mesothelioma; Notch signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)","Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Cyclin D associated events in G1; Interleukin-4 and Interleukin-13 signaling; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Transcriptional Regulation by VENTX; RMTs methylate histone arginines; Transcriptional regulation by RUNX2; RUNX3 regulates WNT signaling; RUNX3 regulates p14-ARF; PTK6 Regulates Cell Cycle; Regulation of RUNX1 Expression and Activity","Endocrine resistance; FoxO signaling pathway; Cell cycle; p53 signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Cellular senescence; Wnt signaling pathway; Hedgehog signaling pathway; Apelin signaling pathway; Hippo signaling pathway; Focal adhesion; Tight junction; JAK-STAT signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Alcoholic liver disease; Hepatitis C; Measles; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Viral myocarditis",47.2,50.5,64.6,47.3,48.7,46.1,1.1421534130893738,0.19175644530519126,0.2795690111860147,0.5535109696101105,0.5153151178801706,0.2879271163869225,4236]
["Low","P24864-1","G1/S-specific cyclin-E1 [OS=Homo sapiens]",2,1,1,1,410,47,6.04,0,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNE1","ENSG00000105173","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; ATM signaling pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Malignant pleural mesothelioma; ID signaling pathway; DNA damage response","CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; G1/S-Specific Transcription; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); RHOBTB3 ATPase cycle; DNA Damage/Telomere Stress Induced Senescence; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle","Cell cycle; Oocyte meiosis; p53 signaling pathway; PI3K-Akt signaling pathway; Cellular senescence; Cushing syndrome; Hepatitis B; Measles; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Prostate cancer; Small cell lung cancer; Gastric cancer",22.8,26.3,32.4,26.3,29.2,30.4,0.9487776484284051,-0.07585807202002373,0.6565044588117721,0.18276231994651623,0.8117160434524651,0.09059587017923036,6315]
["High","P25205","DNA replication licensing factor mcm3 [OS=Homo sapiens]",65,46,326,46,808,90.9,5.77,658.4,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3","ENSG00000112118","Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Unwinding of DNA","DNA replication; Cell cycle",11072,11166,11294.5,12050.6,12015.6,12105.2,0.9270445711252536,-0.10928939142430903,2.2513012859717412E-4,3.6475663805751526,0.016902077346987843,1.7720599152152978,104]
["High","P25490","Transcriptional repressor protein YY1 [OS=Homo sapiens]",28,9,22,9,414,44.7,6.25,49.12,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","YY1","ENSG00000100811","Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Malignant pleural mesothelioma","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; UCH proteinases; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors","",1025.4,1006.7,973.7,1069.5,991.2,1014.3,0.9774959349593496,-0.03283739208494958,0.45200764086779804,0.34485422368712676,0.6698188764273614,0.1740426176012796,5269]
["High","P25788-1","Proteasome subunit alpha type-3 [OS=Homo sapiens]",40,13,55,13,255,28.4,5.33,117.92,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMA3","ENSCANG00000039836; ENSCATG00000039369; ENSCJAG00000018732; ENSCSAG00000014435; ENSG00000100567; ENSGGOG00000015814; ENSMFAG00000002833; ENSMLEG00000041984; ENSMMUG00000003509; ENSMNEG00000035144; ENSNLEG00000013092; ENSPANG00000007163; ENSPPAG00000035468; ENSPPYG00000005855; ENSPTRG00000006390; ENSRROG00000040700; ENSSBOG00000021565","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",3796.4,3892.6,3935.5,3829.2,4265.8,4061.2,0.956261002615949,-0.06452365263586364,0.25247532733996914,0.5977810560548219,0.48698798316958475,0.31248175522792915,4048]
["High","P26358-1","DNA (cytosine-5)-methyltransferase 1 [OS=Homo sapiens]",46,63,199,1,1616,183.1,7.75,415.46,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT1","ENSG00000130816","Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency","NoRC negatively regulates rRNA expression; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer",255.5,282.9,304.7,303.6,264.5,270.6,1.0052462143793965,7.548903155080308E-3,0.9412854063086957,0.026278674562515092,0.9731933861835668,0.011800851193892249,7552]
["High","P26572","alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [OS=Homo sapiens]",5,2,2,2,445,50.8,9.16,6.61,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MGAT1","ENSG00000131446","","Maturation of spike protein; Maturation of spike protein; N-glycan trimming and elongation in the cis-Golgi","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways",204.9,203.5,210.4,165.9,213.8,199.8,1.0678170836928387,0.09466453555520159,0.4136817377827267,0.38333365085998644,0.6397359890290216,0.1939992168968373,5049]
["High","P26641","elongation factor 1-gamma [OS=Homo sapiens]",72,29,252,29,437,50.1,6.67,477.94,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","EEF1G","ENSG00000254772","Translation factors","Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation","Legionellosis",9803.3,9708.8,9822.2,9422.1,9798.8,9524,1.0205045068864391,0.029282553804593825,0.1707924153244958,0.7675314196883383,0.38844951321108745,0.41066541845545296,3433]
["High","P27348","14-3-3 protein theta [OS=Homo sapiens]",69,21,560,15,245,27.7,4.78,1098.18,"transport;signal transduction;other biological processes","cytosol;other cell component","other molecular function","YWHAQ","ENSG00000134308","Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria","Cell cycle; Oocyte meiosis; PI3K-Akt signaling pathway; Hippo signaling pathway; Hepatitis C; Hepatitis B; Viral carcinogenesis",15224.8,15425.3,15276.2,14735.5,15148.2,13963.2,1.047424105238911,0.06684571221846479,0.12064187545170475,0.9185019200486092,0.31684216734843956,0.4991570245949115,2973]
["High","P27635","60S ribosomal protein L10 [OS=Homo sapiens]",46,11,154,11,214,24.6,10.08,304.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPL10","ENSG00000147403","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",4542.3,4161.5,3862.1,4232.8,3773.5,3761,1.0678660355391636,0.09473067138341668,0.3481175696054687,0.45827405718067254,0.5847895833647805,0.23300037190431144,4648]
["High","P27816-5","Isoform 5 of Microtubule-associated protein 4 [OS=Homo sapiens]",42,29,83,1,809,85.2,7.71,105.85,"","","","MAP4","","","","",115.8,129,126.6,115,140.4,126.1,0.9735255570117954,-0.03870924178647214,0.708995499122824,0.14935652181598244,0.8449079452306182,0.07319060590970905,6552]
["High","P28070","Proteasome subunit beta type-4 [OS=Homo sapiens]",48,8,60,8,264,29.2,5.97,122.95,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","other molecular function","PSMB4","ENSG00000159377","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease","Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of RUNX2 expression and activity; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint; UCH proteinases; Regulation of RUNX3 expression and activity; Regulation of ornithine decarboxylase (ODC); ROS sensing by NFE2L2; Regulation of PTEN stability and activity; Regulation of RAS by GAPs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration",1147.3,1130.6,1173.2,1109.3,1254.4,1162.5,0.9787022857466962,-0.03105802586257255,0.6010564571171604,0.2210847328843192,0.7759670663311489,0.1101567107188339,6048]
["Low","P28332-1","Alcohol dehydrogenase 6 [OS=Homo sapiens]",3,1,1,1,368,39.1,7.77,0,"","","","","","","","",87.4,89.7,94.1,76.6,95.3,93.8,1.0207000376364324,0.029558950645837686,0.7859320206696575,0.10461501671480974,0.8879405610459682,0.05161610502514317,6911]
["High","P28799","Granulins [OS=Homo sapiens]",4,2,3,2,593,63.5,6.83,6.9,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GRN","ENSG00000030582","IL-18 signaling pathway","Neutrophil degranulation","",285.8,283.3,292.7,240.5,215.6,254.8,1.2122661415107607,0.2777064635692517,0.012999352944792028,1.8860782645777807,0.09346127789404803,1.0293682851719734,1086]
["High","P29084","transcription initiation factor iie subunit beta [OS=Homo sapiens]",41,10,40,9,291,33,9.66,62.58,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","GTF2E2","ENSG00000197265","Eukaryotic transcription initiation","RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors; Viral carcinogenesis",1231.8,1197.2,1239.6,1255.1,1085.8,1199.6,1.0361813303205762,0.051276494783849144,0.45368036279350277,0.34325001843067765,0.6711512452996722,0.17317959965607307,5278]
["High","P29353","SHC-transforming protein 1 [OS=Homo sapiens]",31,12,25,12,583,62.8,6.44,61.33,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","signal transduction activity or receptor binding;other molecular function","SHC1","ENSG00000160691","IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; IL-4 signaling pathway; p38 MAPK signaling pathway; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; EGF/EGFR signaling pathway; Fragile X syndrome; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Malignant pleural mesothelioma; EPO receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)","Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Interleukin receptor SHC signaling; RET signaling; RAF/MAP kinase cascade; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; Signaling by CSF3 (G-CSF); XBP1(S) activates chaperone genes; SHC1 events in EGFR signaling; Integrin signaling; Erythropoietin activates RAS; Signalling to RAS; Signal attenuation; Interleukin-2 signaling; Interleukin-15 signaling","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; ErbB signaling pathway; Ras signaling pathway; Chemokine signaling pathway; Phospholipase D signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Insulin signaling pathway; Estrogen signaling pathway; Prolactin signaling pathway; Relaxin signaling pathway; Growth hormone synthesis, secretion and action; Alcoholism; Bacterial invasion of epithelial cells; MicroRNAs in cancer; Glioma; Chronic myeloid leukemia; Breast cancer; Hepatocellular carcinoma; Gastric cancer",1098.8,1163.3,1177.4,1116.7,1218.1,1155,0.9855865665654192,-0.02094550249246119,0.6833946784710698,0.16532840733363857,0.8284343501788718,0.08174190183091427,6441]
["High","P29401","Transketolase [OS=Homo sapiens]",70,36,535,36,623,67.8,7.66,1322.77,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","TKT","ENSG00000163931","Pentose phosphate metabolism; VEGFA-VEGFR2 signaling pathway; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways","Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",24552.9,23737.2,23693.9,23548.3,25163.1,25030.1,0.9761667446417553,-0.034800491032883116,0.37557999446128804,0.4252975487979931,0.608408422563016,0.21580478237820727,4820]
["High","P30043","flavin reductase (NADPH) [OS=Homo sapiens]",35,5,13,5,206,22.1,7.65,29.56,"other metabolic processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","BLVRB","ENSG00000090013","Nuclear receptors meta-pathway; NRF2 pathway; IL-10 anti-inflammatory signaling pathway","Cytoprotection by HMOX1; Heme degradation","Riboflavin metabolism; Porphyrin metabolism; Metabolic pathways",378,341.8,316.6,376,310.5,337.2,1.0124059783139592,0.017787931781341932,0.8788299587416055,0.05609514668280326,0.9421810130240912,0.02586565197843826,7283]
["High","P30047","GTP cyclohydrolase 1 feedback regulatory protein [OS=Homo sapiens]",19,1,1,1,84,9.7,6.54,2.46,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","GCHFR","ENSG00000137880","","Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","",17.9,18.6,16.7,15.5,8,15.2,1.3746770025839794,0.4590926793567794,0.12684226888005393,0.8967359981706925,0.32718349369523,0.48520861446863006,3027]
["High","P30153","serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [OS=Homo sapiens]",60,32,294,24,589,65.3,5.11,599.14,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP2R1A","ENSG00000105568","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Cyclin A/B1/B2 associated events during G2/M transition; Regulation of TP53 Degradation; Regulation of PLK1 Activity at G2/M Transition; Cyclin D associated events in G1; Spry regulation of FGF signaling; Negative regulation of MAPK pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; TGF-beta signaling pathway; Hippo signaling pathway; Tight junction; Dopaminergic synapse; Long-term depression; Chagas disease; Hepatitis C; Human papillomavirus infection",10658.3,10441.2,10488.9,10158.3,9932.1,10020.4,1.0490720937338098,0.06911382538737484,0.006131655502452733,2.212422253293629,0.0654937977608084,1.183799825592854,731]
["High","P30291-1","Wee1-like protein kinase [OS=Homo sapiens]",10,6,9,6,646,71.6,6.77,14.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","WEE1","ENSG00000166483","Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control","Factors involved in megakaryocyte development and platelet production; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin A:Cdk2-associated events at S phase entry; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Polo-like kinase mediated events; G2/M DNA replication checkpoint; Cyclin E associated events during G1/S transition","Cell cycle; Human immunodeficiency virus 1 infection",245.6,243.1,240.9,241.2,256.2,272,0.948271380296335,-0.07662810013187303,0.2142741213269833,0.6690302771315187,0.44307530172698245,0.3535224580989147,3776]
["High","P30566","adenylosuccinate lyase [OS=Homo sapiens]",32,16,44,16,484,54.9,7.11,87.55,"other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","ADSL","ENSG00000239900","Nucleotide metabolism","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of cofactors",2695.6,2638.8,2537.5,2867.9,2791.9,2843.1,0.9257900245798494,-0.11124307726373263,0.01491832647059194,1.826279893039755,0.10085047020119642,0.9963220726092827,1155]
["High","P30825","High affinity cationic amino acid transporter 1 [OS=Homo sapiens]",8,4,7,3,629,67.6,5.43,7.41,"transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC7A1","ENSG00000139514","VEGFA-VEGFR2 signaling pathway","Amino acid transport across the plasma membrane","MicroRNAs in cancer",398,393.3,354.5,425.9,405.8,422.5,0.9135704034444267,-0.13041218181313138,0.07516706914342006,1.123972383100382,0.24454353161325992,0.6116438201533526,2400]
["High","P31040","Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [OS=Homo sapiens]",34,15,42,15,664,72.6,7.39,113.53,"other metabolic processes;developmental processes","other membranes;mitochondrion;nucleus","other molecular function","SDHA","ENSG00000073578","Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)","Respiratory electron transport; Citric acid cycle (TCA cycle)","Citrate cycle (TCA cycle); Oxidative phosphorylation; Metabolic pathways; Carbon metabolism; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",1709.9,1616.9,1670.2,1464.3,1460,1546.5,1.1176970564552207,0.16052920931289238,0.010806701478727762,1.9663068451946721,0.0848027388401069,1.0715901212817622,995]
["High","P31350-1","ribonucleoside-diphosphate reductase subunit M2 [OS=Homo sapiens]",40,12,34,11,389,44.8,5.38,64.89,"cell organization and biogenesis;other metabolic processes;developmental processes","cytosol","other molecular function","RRM2","ENSG00000171848","Fluoropyrimidine activity; Retinoblastoma gene in cancer; Hepatitis C and hepatocellular carcinoma; Pyrimidine metabolism; Nucleotide metabolism; Orexin receptor pathway","G1/S-Specific Transcription; Transcriptional Regulation by E2F6; Interconversion of nucleotide di- and triphosphates","Purine metabolism; Pyrimidine metabolism; Glutathione metabolism; Drug metabolism; Metabolic pathways; p53 signaling pathway",786.5,832.7,805.1,835.3,916.2,845.7,0.933428307407978,-0.0993888753484758,0.11539023580897374,0.937830939132562,0.30739234431813955,0.5123069529123622,2931]
["High","P31689-1","DnaJ homolog subfamily A member 1 [OS=Homo sapiens]",65,20,120,20,397,44.8,7.08,309.2,"stress response;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","Dnaja1; DNAJA1; LOC109263810; LOC111146318; LOC112809310","ENSCAFG00000001474; ENSCAFG00000001818; ENSCATG00000033398; ENSCJAG00000008022; ENSCPOG00000000462; ENSECAG00000010324; ENSFCAG00000008729; ENSG00000086061; ENSGGOG00000007030; ENSLCNG00005016649; ENSMFAG00000032081; ENSMLEG00000042863; ENSMMUG00000007740; ENSMNEG00000030895; ENSNLEG00000005268; ENSOCUG00000004833; ENSPANG00000025299; ENSPPAG00000027533; ENSPPYG00000019141; ENSPTRG00000020852; ENSRROG00000029815; ENSSSCG00000011000; ENSSSCG00070018491; ENSSSUG00005020902; ENSSTOG00000005200","VEGFA-VEGFR2 signaling pathway; Exercise-induced circadian regulation","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","Protein processing in endoplasmic reticulum",4035.4,4143,4149.9,4434.8,4219.3,4385.9,0.9454217791411043,-0.08096999526700739,0.03411926215477336,1.467000369227119,0.15560934515448038,0.8079643249096179,1712]
["High","P31947-1","14-3-3 protein sigma [OS=Homo sapiens]",38,8,125,4,248,27.8,4.74,270.24,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","enzyme regulator activity;other molecular function","SFN","ENSG00000175793; ENSGGOG00000011493; ENSNLEG00000018582; ENSPPAG00000013397; ENSPTRG00000030723","miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; DNA damage response; Calcium regulation in cardiac cells","TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","Cell cycle; p53 signaling pathway; Aldosterone-regulated sodium reabsorption",265.6,293.4,318.2,310.7,313.3,327,0.9223974763406941,-0.11653952907433207,0.19925433650785088,0.7005922179823584,0.42380219543810943,0.37283679782770973,3671]
["High","P32322","Pyrroline-5-carboxylate reductase 1, mitochondrial [OS=Homo sapiens]",39,9,34,8,319,33.3,7.61,98.14,"other metabolic processes;stress response;other biological processes","mitochondrion","other molecular function","PYCR1","ENSG00000183010","Amino acid metabolism; Metabolic reprogramming in colon cancer","Glutamate and glutamine metabolism","Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids",1452.4,1496.4,1474.7,1488.3,1632.5,1603.7,0.9362895544502065,-0.0949733319928677,0.0938839539627811,1.027408628190861,0.2752707144353717,0.5602399899711666,2663]
["High","P32519-1","ETS-related transcription factor Elf-1 [OS=Homo sapiens]",9,4,4,4,619,67.5,5.21,8.15,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ELF1","ENSG00000120690; ENSGGOG00000010760","","RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX1 regulates transcription of genes involved in BCR signaling","",89.4,116.1,118.4,86.8,91.6,97.1,1.1756805807622503,0.23349614933666654,0.17405903270107492,0.7593034343133637,0.3927898633901714,0.4058397284475048,3460]
["High","P33897","ATP-binding cassette sub-family D member 1 [OS=Homo sapiens]",9,6,10,6,745,82.9,8.95,17.78,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ABCD1","ENSG00000101986","Vitamin D receptor pathway","Class I peroxisomal membrane protein import; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids; Linoleic acid (LA) metabolism; ABC transporters in lipid homeostasis; Defective ABCD1 causes ALD","ABC transporters; Peroxisome",492.6,484.6,449.8,445.7,452.7,420.7,1.0817981957395195,0.11343139642932264,0.09251016494814533,1.0338105446842751,0.2737094990205073,0.5627101302456894,2639]
["Low","P34741","syndecan-2 [OS=Homo sapiens]",5,1,1,1,201,22.1,4.86,0,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SDC2","ENSG00000169439","miRNA targets in ECM and membrane receptors","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cell surface interactions at the vascular wall; Syndecan interactions; EPHB-mediated forward signaling; A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Cell adhesion molecules; Malaria; Proteoglycans in cancer; Fluid shear stress and atherosclerosis",166.8,150.9,152,164.3,151.4,182.9,0.9420377055756117,-0.08614328923371303,0.41007955349148706,0.38713188403412124,0.6364343378377123,0.1962463967012341,5031]
["High","P34897-1","Serine hydroxymethyltransferase, mitochondrial [OS=Homo sapiens]",66,29,163,27,504,56,8.53,376.49,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","HEL-S-51e; SHMT2","ENSG00000182199","Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling","RHOG GTPase cycle; Metabolism of folate and pterines","Glycine, serine and threonine metabolism; Glyoxylate and dicarboxylate metabolism; One carbon pool by folate; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors; Antifolate resistance",6134.2,6027.2,6191.3,6007.4,6144,6190,1.000616092555639,8.8855998525030672E-4,0.9612894553655218,0.01714582155111443,0.9819136666004702,0.00792669527545429,7644]
["High","P35222","Catenin beta-1 [OS=Homo sapiens]",38,22,85,20,781,85.4,5.86,241.42,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CTNNB1","ENSG00000168036","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Heart development; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Gastric cancer network 2; Brain-derived neurotrophic factor (BDNF) signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Endoderm differentiation; Ectoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Focal adhesion; Ectoderm differentiation; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; OSX and miRNAs in tooth development; Wnt signaling pathway and pluripotency; PTF1A related regulatory pathway; Wnt signaling in kidney disease; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Genes controlling nephrogenesis; GDNF/RET signaling axis; Mammalian disorder of sexual development; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; 1q21.1 copy number variation syndrome; 7q11.23 copy number variation syndrome; Development of ureteric collection system; Malignant pleural mesothelioma; Alzheimer's disease; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response (only ATM dependent)","Deactivation of the beta-catenin transactivating complex; InlA-mediated entry of Listeria monocytogenes into host cells; RHO GTPases activate IQGAPs; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Myogenesis; Transcriptional Regulation by VENTX; Ca2+ pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; Apoptotic cleavage of cell adhesion  proteins; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production","Rap1 signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Leukocyte transendothelial migration; Melanogenesis; Thyroid hormone signaling pathway; Cushing syndrome; Alcoholic liver disease; Alzheimer disease; Pathways of neurodegeneration; Bacterial invasion of epithelial cells; Salmonella infection; Hepatitis C; Human cytomegalovirus infection; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Proteoglycans in cancer; Colorectal cancer; Endometrial cancer; Prostate cancer; Thyroid cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Arrhythmogenic right ventricular cardiomyopathy; Fluid shear stress and atherosclerosis",3661.9,3663.6,3741.4,3738.8,3778,3777.2,0.979891978041438,-0.029305377632531677,0.06074351205158167,1.2165001017735724,0.21637105022753178,0.6648008469272686,2192]
["High","P35249","replication factor C subunit 4 [OS=Homo sapiens]",61,19,43,19,363,39.7,8.02,86.27,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC4","ENSG00000163918","Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","Activation of ATR in response to replication stress; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",1850.9,1802.5,1867.1,2032.2,1909.8,1940.2,0.9385094012444324,-0.09155689798167815,0.0441918869156532,1.3546574544331662,0.18084394813281982,0.7426960201426072,1908]
["High","P35250-1","Replication factor C subunit 2 [OS=Homo sapiens]",57,17,59,17,354,39.1,6.44,147.72,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC2","ENSG00000049541","DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Dual Incision in GG-NER; Termination of translesion DNA synthesis; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",1967,2072.3,2091.9,1995.2,2178.1,2034.7,0.9876288659793815,-0.01795909133830972,0.7247735302169312,0.13979767610751387,0.8539356758614455,0.06857484203997583,6627]
["High","P35555","Fibrillin-1 [OS=Homo sapiens]",3,8,10,5,2871,312,4.93,18.2,"","extracellular matrix","extracellular structural activity;other molecular function","","","","","",104.3,85.4,106.1,85.7,78.5,79.1,1.2157829839704068,0.28188573216063845,0.06703958247890121,1.1736686991461858,0.22669773061726317,0.6445528274047267,2309]
["High","P35610","sterol O-acyltransferase 1 [OS=Homo sapiens]",13,6,13,6,550,64.7,8.94,16.73,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","other molecular function","SOAT1","ENSG00000057252","Statin inhibition of cholesterol production; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","LDL clearance","Steroid biosynthesis; Cholesterol metabolism",360.3,331.6,361.4,295.8,287.5,312.2,1.1762144053601342,0.2341510647285879,0.012386458812186885,1.9070528371384516,0.09072558199395422,1.0422702371703696,1066]
["High","P35611-4","Isoform 4 of Alpha-adducin [OS=Homo sapiens]",43,22,80,2,662,73.3,6.16,141.49,"","","","ADD1","","","","",37.8,46.9,49.2,53,39.1,43,0.9911176905995558,-0.012871714001374124,0.9445920534413116,0.024755712328136534,0.9739039684761337,0.011483864494113961,7573]
["High","P35813","Protein phosphatase 1A [OS=Homo sapiens]",36,12,35,11,382,42.4,5.36,68.31,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","PPM1A","ENSG00000100614","TGF-beta signaling pathway; MAPK signaling pathway","Downregulation of SMAD2/3:SMAD4 transcriptional activity; Energy dependent regulation of mTOR by LKB1-AMPK","MAPK signaling pathway",1393.2,1436.3,1359.5,1368,1452.5,1480.3,0.9740048363095236,-0.03799915902487491,0.40877100170806613,0.38851992071303093,0.6356669948887832,0.19677033742874242,5021]
["High","P36405","ADP-ribosylation factor-like protein 3 [OS=Homo sapiens]",59,9,46,9,182,20.4,7.24,88.28,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","ARL3","ENSG00000138175","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","Trafficking of myristoylated proteins to the cilium","",1513.3,1372.8,1338.5,1294.9,1306.8,1231.3,1.102165405687451,0.1403407502776023,0.08904242195677896,1.05040303568863,0.26843367978321625,0.5711629951112464,2590]
["High","P36543","V-type proton ATPase subunit E 1 [OS=Homo sapiens]",54,13,38,13,226,26.1,8,79.95,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V1E1","ENSG00000131100","VEGFA-VEGFR2 signaling pathway; Proximal tubule transport","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",1970.3,1919.7,1897.5,1878.1,1810.7,1831.6,1.0483841750597784,0.06816748203813609,0.03860767537303133,1.4133263471213102,0.1659959963175268,0.779902386647741,1816]
["High","P36915-1","Guanine nucleotide-binding protein-like 1 [OS=Homo sapiens]",26,13,33,13,607,68.6,5.8,68.26,"stress response;signal transduction;other biological processes","non-structural extracellular","other molecular function","GNL1","ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986","","","",953,902.4,908.8,870.1,877.6,903.9,{"$f":"AVERAGE(T1858:V1858)/AVERAGE(W1858:Y1858)","v":1.0424649268366268},{"$f":"LOG(Z1858,2)","v":0.059998845799377906},{"$f":"TTEST(T1858:V1858,W1858:Y1858,2,2)","v":0.11832792152062514},{"$f":"-LOG10(AB1858)","v":0.9269127639812633},{"$f":"AB1858*7808/AF1858","v":0.31340041086602477},{"$f":"-LOG10(AD1858)","v":0.5039004385096418},2948]
["High","P36955","Pigment epithelium-derived factor [OS=Homo sapiens]",5,2,4,2,418,46.3,6.38,8.18,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other cell component","enzyme regulator activity","SERPINF1","ENSG00000132386","lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Type I collagen synthesis in the context of osteogenesis imperfecta; GPR143 in melanocytes and retinal pigment epithelium cells; Malignant pleural mesothelioma","","Wnt signaling pathway",85,72.6,81.9,72.6,92.8,85.1,0.9560878243512975,-0.06478494745902807,0.6264670121197453,0.20310179271700088,0.7943251754840811,0.10000167262554477,6158]
["High","P37837","Transaldolase [OS=Homo sapiens]",44,17,161,17,337,37.5,6.81,329.5,"other metabolic processes","cytosol;other cell component","other molecular function","TALDO1","ENSG00000177156","Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of  Fru(6)P, E4P to SH7P, GA3P","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids",9383,9477.2,9456.1,9028.6,9062,8986.8,1.0457540236507201,0.06454354891646655,3.2556047324187388E-4,3.487368328890297,0.018287598381816914,1.7378433244857563,139]
["High","P38159-2","Isoform 2 of RNA-binding motif protein, X chromosome [OS=Homo sapiens]",67,34,266,11,378,40.8,10.04,391.98,"","","","RBMX","","","","",13501.8,14572.9,14494.2,16167.5,15243.1,16476.9,0.8889355259723308,-0.16984930995280842,0.024831634639070396,1.6049946903785322,0.132889241440618,0.8765101776133484,1459]
["High","P39023","60S ribosomal protein L3 [OS=Homo sapiens]",47,22,295,22,403,46.1,10.18,487.69,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","other molecular function","RPL3","ENSG00000100316","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",11575.3,11684,11700.4,11173.9,12157.3,11959.9,0.9906095304481866,-0.013611593979445351,0.7338087000769403,0.13441714352990902,0.8601678922385153,0.06541677252813258,6661]
["High","P40123","Adenylyl cyclase-associated protein 2 [OS=Homo sapiens]",32,14,33,13,477,52.8,6.37,71.97,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","cytoskeletal activity;other molecular function","CAP2","ENSG00000112186","Ectoderm differentiation; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway","Role of ABL in ROBO-SLIT signaling","",1479.6,1384.6,1401.6,1442.4,1503.2,1469.9,0.9660967047899445,-0.049760487049910276,0.21747138136847927,0.6625978869002336,0.4469640815280564,0.3497273757963185,3799]
["High","P40429","60S ribosomal protein L13a [OS=Homo sapiens]",42,12,97,12,203,23.6,10.93,170.49,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","RPL13A","ENSG00000142541","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",5452.2,5253,4987.6,4908,5689,5216,0.9923986593309303,-0.011008308647269227,0.8867170319884912,0.05221494956212808,0.9469958399351852,0.023651928807879415,7311]
["High","P40937-1","Replication factor C subunit 5 [OS=Homo sapiens]",68,20,58,20,340,38.5,7.2,116.44,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC5","ENSG00000111445","Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","HDR through Homologous Recombination (HRR); Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Termination of translesion DNA synthesis; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","DNA replication; Nucleotide excision repair; Mismatch repair",2658.8,2743.8,2721.4,2662.9,3022,2883.7,0.9481128772494926,-0.07686926598132353,0.24053406121595614,0.6188234159607428,0.4722378551607205,0.32583920228808777,3977]
["Medium","P41217","OX-2 membrane glycoprotein [OS=Homo sapiens]",4,1,1,1,278,31.2,8.51,2.55,"cell adhesion;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CD200","ENSG00000091972","Vitamin D receptor pathway","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","",135,143,142.7,151.9,170.2,138.5,0.9133738601823708,-0.13072259302405614,0.23626520713806487,0.6266002286870668,0.46821287749594176,0.32955664585400546,3940]
["High","P41225","Transcription factor SOX-3 [OS=Homo sapiens]",29,7,13,7,446,45.2,9.77,44.52,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SOX3","ENSG00000134595","","Deactivation of the beta-catenin transactivating complex","",284.7,338.1,318.6,228.8,249,232.7,1.3249824067558058,0.40597320355911115,0.010137181129491272,1.994082793533478,0.08270753423100088,1.082454926651686,957]
["High","P41273","Tumor necrosis factor ligand superfamily member 9 [OS=Homo sapiens]",11,2,2,2,254,26.6,7.02,0,"cell-cell signaling;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding","TNFSF9","ENSG00000125657","Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling","TNFs bind their physiological receptors","Cytokine-cytokine receptor interaction",20.6,19.4,14,19.7,15.6,18.9,{"$f":"AVERAGE(T1922:V1922)/AVERAGE(W1922:Y1922)","v":0.996309963099631},{"$f":"LOG(Z1922,2)","v":-0.005333444303040596},{"$f":"TTEST(T1922:V1922,W1922:Y1922,2,2)","v":0.979050497406095},{"$f":"-LOG10(AB1922)","v":0.009194907605200845},{"$f":"AB1922*7808/AF1922","v":0.9902106585164235},{"$f":"-LOG10(AD1922)","v":4.272403282301579E-3},7720]
["High","P42167","Lamina-associated polypeptide 2, isoforms beta/gamma [OS=Homo sapiens]",52,19,144,6,454,50.6,9.38,338.34,"","other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","TMPO","ENSG00000120802","Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RHOC GTPase cycle; RHOJ GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle","",3395.3,3017.1,2918.5,3044.2,2987.5,3001.7,1.032933336285341,0.04674714818750725,0.53508850893909,0.2715743754281555,0.7292670758939457,0.13711339301913264,5729]
["High","P42285","Superkiller viralicidic activity 2-like 2 [OS=Homo sapiens]",36,35,115,34,1042,117.7,6.52,206.2,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus","other molecular function","MTREX","ENSG00000039123","","mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol","RNA degradation",4467,4407.8,4497.3,4808.7,5147.4,5068.4,0.8900196345968251,-0.16809093136674147,0.006451867596078821,2.190314553695099,0.06743799489984395,1.1710953508518624,747]
["High","P42575-1","caspase-2 [OS=Homo sapiens]",3,2,2,2,452,50.7,6.81,6.43,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","CASP2","ENSG00000106144; ENSPPAG00000028627; ENSPTRG00000019805; ENSPTRG00000047033","Apoptosis modulation and signaling; Parkinson's disease pathway; Apoptosis; Apoptosis modulation by HSP70; Acute viral myocarditis; Apoptosis modulation by HSP70","TP53 Regulates Transcription of Caspase Activators and Caspases; NOD1/2 Signaling Pathway; NADE modulates death signalling","Apoptosis",82.7,83,100.5,102.3,105.8,102.7,0.8564993564993565,-0.22347593249581835,0.06798137275441332,1.1676100699140755,0.22898988717276067,0.6401836968830171,2318]
["High","P42695","condensin-2 complex subunit D3 [OS=Homo sapiens]",14,15,27,15,1498,168.8,7.5,41.1,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","other molecular function","NCAPD3","ENSG00000151503","","Condensation of Prophase Chromosomes","",1104.7,1140.2,1115.8,1131.8,1106.4,1126.5,0.998811186732844,-0.001716115277606418,0.9234212854944251,0.03460011888361023,0.9640424384463794,0.015903847448410707,7479]
["High","P42858","huntingtin [OS=Homo sapiens]",13,33,62,33,3142,347.4,6.2,114.75,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","HTT","ENSG00000197386","Mesodermal commitment pathway; Mesodermal commitment pathway; ERK pathway in Huntington's disease; Rett syndrome causing genes","Regulation of MECP2 expression and activity","Huntington disease; Pathways of neurodegeneration",2646.4,2538.2,2505.9,2503.4,2535.7,2555.3,1.0126540608869694,0.018141410189561898,0.5167496498869937,0.2867198089477921,0.7186999049372367,0.14345241258757702,5614]
["High","P43155","Carnitine O-acetyltransferase [OS=Homo sapiens]",8,4,5,4,626,70.8,8.44,10.23,"other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","CRAT","ENSG00000095321","Fatty acid beta-oxidation","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","",264.7,274.6,235.7,227.3,234.4,238.1,1.107459274078308,0.14725364580911274,0.10691759360562603,0.9709508244717916,0.2945704202091489,0.5308108657245978,2834]
["High","P43304","Glycerol-3-phosphate dehydrogenase, mitochondrial [OS=Homo sapiens]",44,25,80,25,727,80.8,7.69,158.64,"other metabolic processes","other membranes;mitochondrion;other cell component","other molecular function","GPD2","ENSG00000115159","Fatty acid beta-oxidation","Triglyceride catabolism; Synthesis of PA","Glycerophospholipid metabolism",3196,3260.6,3248.2,3310.2,3733,3494.6,0.9209512421947654,-0.11880331697015922,0.0886488013001668,1.0523271325079893,0.26776396152870496,0.5722478752793152,2585]
["High","P45880","Voltage-dependent anion-selective channel protein 2 [OS=Homo sapiens]",68,16,150,15,294,31.5,7.56,373.23,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","VDAC2","ENSG00000165637","Alzheimer's disease and miRNA effects; Ferroptosis; Alzheimer's disease","Ub-specific processing proteases; Mitochondrial calcium ion transport","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy",6002.5,6131.8,6249.6,5318.8,6225.2,5881.1,1.0550240744672916,0.07727591999245731,0.3076881342992973,0.5118892515838777,0.5443981311146415,0.26408337437243484,4413]
["High","P45984-1","Mitogen-activated protein kinase 9 [OS=Homo sapiens]",10,5,14,4,424,48.1,5.63,22.71,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","MAPK9","ENSG00000050748; ENSGGOG00000016519; ENSOCUG00000015542; ENSPPAG00000038007; ENSPTRG00000017633","IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Wnt signaling pathway and pluripotency; Splicing factor NOVA regulated synaptic proteins; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; CCL18 signaling pathway; Familial partial lipodystrophy (FPLD); Alzheimer's disease; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway; MAPK signaling pathway; Wnt signaling pathway","Oxidative Stress Induced Senescence; FCERI mediated MAPK activation; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors","Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; cAMP signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Mitophagy; Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Apoptosis; Necroptosis; Wnt signaling pathway; Osteoclast differentiation; Focal adhesion; Tight junction; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; Insulin signaling pathway; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Adipocytokine signaling pathway; Relaxin signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Measles; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Choline metabolism in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",380.5,401,402.3,360.7,346.6,333.8,1.1370665642109308,0.18531671249409143,0.010566315341289862,1.9760764323639668,0.0840140429580359,1.075648115492281,982]
["High","P46087-2","Isoform 2 of Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase [OS=Homo sapiens]",44,30,141,30,808,88.9,9.23,295.98,"","","","NOP2","","","","",5375.9,5777.5,5762.4,5515.3,5272.3,5603.1,1.0320364596997076,0.045493939073978334,0.3472801088637559,0.4593200910287177,0.5837595457498829,0.23376600469974285,4645]
["High","P46736","Lys-63-specific deubiquitinase BRCC36 [OS=Homo sapiens]",27,8,23,8,316,36,5.92,53.29,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","BRCC3","ENSG00000185515","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","Homologous recombination; NOD-like receptor signaling pathway",739.1,793.9,786.6,743,742.3,745.2,1.039946200403497,0.05650889527145469,0.15932429864079944,0.7977179846453729,0.3750389278828345,0.42592365150621986,3317]
["High","P46777","60S ribosomal protein L5 [OS=Homo sapiens]",64,20,329,20,297,34.3,9.72,573.24,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL5","ENSG00000122406","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",16425.4,15733.1,15710.4,15888.1,16224.6,16035.1,0.9942074196536498,-0.008381224902372359,0.7329458814298362,0.13492809120345617,0.8599310957481834,0.06553634635551472,6655]
["High","P46934-4","Isoform 4 of E3 ubiquitin-protein ligase NEDD4 [OS=Homo sapiens]",6,5,7,3,900,104.2,5.97,7.19,"","","","NEDD4","","","","",12.3,11.8,13.8,16.3,8.2,11.8,1.0440771349862261,0.06222830017534132,0.8362897434149339,0.07764322954022777,0.9192947087968188,0.036545239553647406,7103]
["High","P47895","Aldehyde dehydrogenase family 1 member A3 [OS=Homo sapiens]",20,11,19,8,512,56.1,7.25,35.56,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","ALDH1A3","ENSG00000184254","Ethanol effects on histone modifications; Vitamin A and carotenoid metabolism","RA biosynthesis pathway","Retinol metabolism; Metabolic pathways",538.3,577.2,541.4,608.3,593,576.1,0.9322043434229774,-0.10128186004076499,0.06129309321287538,1.2125884610204554,0.2170414838123043,0.6634572501656772,2205]
["High","P47897","glutamine--tRNA ligase [OS=Homo sapiens]",51,38,153,37,775,87.7,7.15,333.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;mitochondrion;other cell component","enzyme regulator activity;other molecular function","QARS1","ENSG00000172053","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis; Metabolic pathways",6545.2,6341.7,6549.2,5576.2,5933.5,5954,1.1129428471629723,0.1543795080153216,0.009450289138770848,2.0245549037180717,0.08055442968943535,1.0939105727272866,916]
["High","P48200","iron-responsive element-binding protein 2 [OS=Homo sapiens]",4,4,4,4,963,105,7.05,6.34,"","","","","","","","",145.6,137,148.1,130.6,118.2,135.5,1.1207390059849078,0.16445034717905602,0.06567058771723948,1.1826290969876931,0.224400852908624,0.6489754967349268,2285]
["High","P48444","Coatomer subunit delta [OS=Homo sapiens]",49,22,104,22,511,57.2,6.21,174.94,"transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","","ARCN1","ENSG00000095139","miR-517 relationship with ARCN1 and USP1","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",4779.7,4887.4,4780.5,4587.6,5061.1,4815.7,0.9988385276955833,-1.6766241985901196E-3,0.9702897847034475,0.013098540885874034,0.9856912098574705,0.006259116355568565,7686]
["High","P48553","Trafficking protein particle complex subunit 10 [OS=Homo sapiens]",3,3,4,3,1259,142.1,6.04,10.65,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC10","ENSG00000160218","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",110.6,119.3,122.2,111,125,114,1.006,0.008630305143440056,0.9048800975022889,0.04340896382570838,0.9546417783134539,0.02015956337647144,7401]
["High","P48681","Nestin [OS=Homo sapiens]",55,73,259,73,1621,177.3,4.36,559.8,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;other molecular function","NES","ENSG00000132688","","","",9755.9,11516.1,10883.9,12483.3,9682.2,10028.2,0.9988258572329368,-1.6949251842452344E-3,0.9907446175557212,0.004038278390390571,0.9959745041682851,1.7517788862896537E-3,7767]
["High","P49023","Paxillin [OS=Homo sapiens]",32,12,31,12,591,64.5,6.19,52.07,"cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PXN","ENSG00000089159","Integrin-mediated cell adhesion; Prolactin signaling pathway; Oncostatin M signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; 3q29 copy number variation syndrome; Regulation of actin cytoskeleton","VEGFA-VEGFR2 Pathway; GAB1 signalosome; Smooth Muscle Contraction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","Chemokine signaling pathway; VEGF signaling pathway; Focal adhesion; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Human papillomavirus infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis; Proteoglycans in cancer",1077.3,1081.8,1137.1,1176.3,1054.9,1102.7,0.9886919223731966,-0.016407049438538844,0.770221626408072,0.11338429135100576,0.8797382181091613,0.055646540741069554,6836]
["High","P49069","calcium signal-modulating cyclophilin ligand [OS=Homo sapiens]",22,5,9,5,296,32.9,8.05,27.55,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","CAMLG","ENSG00000164615","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",356.9,306.1,313.8,303.7,297.4,302,1.0816077953714982,0.1131774545723012,0.19764033969393086,0.7041244083392241,0.4216327246803858,0.3750656890749994,3660]
["High","P49327","Fatty acid synthase [OS=Homo sapiens]",60,115,750,114,2511,273.3,6.44,1825.21,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","FASN","ENSG00000169710","AMP-activated protein kinase (AMPK) signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway","ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism","Fatty acid biosynthesis; Metabolic pathways; Fatty acid metabolism; AMPK signaling pathway; Insulin signaling pathway; Alcoholic liver disease",30626.7,30727.4,31003.7,28370.4,30789.1,29945.9,1.0365005936789466,0.051720942783484845,0.20542417395498216,0.6873484507216957,0.4322155619079765,0.3642996004118434,3711]
["High","P49406","39S ribosomal protein L19, mitochondrial [OS=Homo sapiens]",35,10,18,9,292,33.5,9.5,36.57,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPL19","ENSG00000115364","Cytoplasmic ribosomal proteins","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",919.3,917.5,948.4,861.4,1063.3,958.5,0.9660099889012209,-0.04988998774789994,0.6101778390829796,0.2145435694545858,0.7819249249236673,0.1068349429204196,6093]
["High","P49441","Inositol polyphosphate 1-phosphatase [OS=Homo sapiens]",14,3,4,3,399,44,5.26,7.09,"other metabolic processes;signal transduction","cytosol","other molecular function","INPP1","ENSG00000151689","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",30.2,38.1,40.7,31.9,36.1,34.2,1.0665362035225048,0.09293293872666722,0.539499912790493,0.26800862118424146,0.7325939685335948,0.13513666121523646,5750]
["High","P49591","Serine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",47,24,116,24,514,58.7,6.43,211.34,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SARS1","ENSG00000031698","VEGFA-VEGFR2 signaling pathway","Cytosolic tRNA aminoacylation; Selenocysteine synthesis","Aminoacyl-tRNA biosynthesis",4060.5,4153.8,4077.3,4079.7,4143.2,4083.8,0.9987730260752272,-1.7712360491408002E-3,0.8934798593429818,0.04891523283353621,0.9505778364559206,0.022012315874529485,7339]
["High","P49736","DNA replication licensing factor mcm2 [OS=Homo sapiens]",58,46,213,46,904,101.8,5.52,476.82,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM2","ENSG00000073111","Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","DNA replication; Cell cycle",7646,7556.1,7752.6,7822.6,8441.5,8269.4,0.9356471763099435,-0.0959634891691039,0.05260265817424055,1.2789923090547086,0.19986450366154268,0.6992643306081612,2055]
["High","P49756-1","RNA-binding protein 25 [OS=Homo sapiens]",39,36,103,36,843,100.1,6.32,213.46,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RBM25","ENSG00000119707; ENSGGOG00000002415; ENSPPAG00000039402; ENSPTRG00000006509","","","Spliceosome",4801.9,5270,5255.2,5236.7,5087.4,5218.9,0.9861095026700123,-0.020180235112503955,0.6774185333483345,0.16914292575928436,0.8250325859279044,0.08352889798438083,6411]
["High","P49773","Histidine triad nucleotide-binding protein 1 [OS=Homo sapiens]",40,5,14,5,126,13.8,6.95,36.19,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","HINT1","ENSG00000169567","","","",1100.4,1028,993.1,1045.1,977,953.3,1.0491026416616256,0.06915583460922742,0.30972890810256487,0.5090182585000946,0.5461525100417404,0.26268606604814443,4428]
["High","P49840","Glycogen synthase kinase-3 alpha [OS=Homo sapiens]",30,8,17,6,483,50.9,8.75,34.2,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","GSK3A","ENSG00000105723","IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation","XBP1(S) activates chaperone genes; Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein","Chemokine signaling pathway; Dopaminergic synapse; Non-alcoholic fatty liver disease; Shigellosis",290.3,289.7,284.8,281.8,313.8,288.2,0.9785019235121069,-0.031353408022355124,0.5582922979380074,0.25313836352713764,0.7464291545034181,0.12701140598090174,5840]
["High","P49915","GMP synthase [glutamine-hydrolyzing] [OS=Homo sapiens]",73,43,195,43,693,76.7,6.87,428.98,"other metabolic processes","cytosol","other molecular function","GMPS","ENSG00000163655","","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Drug metabolism; Metabolic pathways",8060,7755.2,7998.7,8352.5,9077.2,8701.7,0.9113135920769648,-0.13398050970235623,0.02796331556667904,1.5534113362545232,0.14113611373279247,0.8503618452952553,1547]
["High","P50148","Guanine nucleotide-binding protein G(Q) subunit alpha [OS=Homo sapiens]",12,5,10,4,359,42.1,5.68,22.41,"cell-cell signaling;stress response;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","GNAQ","ENSG00000156052","Thyroid stimulating hormone (TSH) signaling pathway; Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Circadian rhythm genes; Cell-type dependent selectivity of CCK2R signaling; Hippo signaling regulation pathways; Gastrin signaling pathway; PKC-gamma calcium signaling pathway in ataxia; GPR143 in melanocytes and retinal pigment epithelium cells; Airway smooth muscle cell contraction; Prostaglandin and leukotriene metabolism in senescence ; Alzheimer's disease; Calcium regulation in cardiac cells; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 2 and STAT3 signaling","G alpha (q) signalling events; Thrombin signalling through proteinase activated receptors (PARs); G-protein activation; ADP signalling through P2Y purinoceptor 1; Thromboxane signalling through TP receptor; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Apelin signaling pathway; Gap junction; Platelet activation; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Yersinia infection; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",311.7,300,292.9,277.3,326,283.7,1.0198421645997746,0.028345891442985074,0.7360651633657982,0.13308373615508642,0.8607453640197922,0.06512530772993365,6677]
["High","P50395-1","Rab GDP dissociation inhibitor beta [OS=Homo sapiens]",74,32,218,24,445,50.6,6.47,449.1,"transport;signal transduction","non-structural extracellular;other membranes;cytosol;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","GDI2","ENSG00000057608; ENSNLEG00000035201","","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs","",9785.2,9603.2,9965.8,9106.4,10169.9,9595.9,1.0166942595299286,0.023885896918429034,0.6466423797153712,0.1893358359549086,0.8064180962813637,0.09343973508138965,6261]
["High","P50479-1","PDZ and LIM domain protein 4 [OS=Homo sapiens]",3,1,1,1,330,35.4,7.91,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","PDLIM4","ENSG00000131435; ENSPTRG00000017214","","","",116.5,108,121.9,101.4,102.6,110.7,1.1007308547823325,0.13846175142830125,0.10160868237518045,0.9930691803737116,0.28599877144391095,0.5436358324523423,2774]
["High","P50552","Vasodilator-stimulated phosphoprotein [OS=Homo sapiens]",57,16,65,16,380,39.8,8.94,143.39,"cell organization and biogenesis;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","VASP","ENSG00000125753","Integrin-mediated cell adhesion; Focal adhesion","Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions","Rap1 signaling pathway; cGMP-PKG signaling pathway; Focal adhesion; Tight junction; Platelet activation; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration",2158.6,2213.9,2120.5,2182.5,2102.9,2065.9,1.0223103931478597,0.03183329281907785,0.3415644997335117,0.4665272737295822,0.5777590151471533,0.23825326921862172,4616]
["High","P50851-1","Lipopolysaccharide-responsive and beige-like anchor protein [OS=Homo sapiens]",19,35,60,1,2863,318.9,5.6,118.25,"other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","LRBA","ENSG00000198589","","","",2295.8,2234.6,2218.4,2142.3,2141.1,2116.9,1.0544505726294082,0.07649147038650564,0.009656976471625198,2.015158826713787,0.08133945230900708,1.0896987561996487,927]
["High","P50991","T-complex protein 1 subunit delta [OS=Homo sapiens]",71,31,355,31,539,57.9,7.83,816.82,"transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CCT4","ENSG00000115484","16p11.2 proximal deletion syndrome","Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; Folding of actin by CCT/TriC","",12700.5,12870.6,12749.1,12586.8,13789.3,13242.7,0.9672226316799094,-0.04808009282474728,0.2853230659882892,0.5446631178399097,0.521733606378586,0.2825511882062981,4270]
["High","P51148","Ras-related protein Rab-5C [OS=Homo sapiens]",74,11,46,9,216,23.5,8.41,119.88,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","RAB5C","ENSG00000108774","Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells","Clathrin-mediated endocytosis; Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Golgi Associated Vesicle Biogenesis; TBC/RABGAPs","Ras signaling pathway; Endocytosis; Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection; Amoebiasis; Tuberculosis",1442.8,1381.4,1346.1,1207,1423,1317.7,1.0563872634698683,0.07913881260057706,0.33940436014290315,0.46928258283790647,0.5767288887912487,0.23902829390140112,4595]
["High","P51511","Matrix metalloproteinase-15 [OS=Homo sapiens]",7,3,4,3,669,75.8,7.46,11.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes","enzyme regulator activity;other molecular function","MMP15","ENSG00000102996","Matrix metalloproteinases; Epithelial to mesenchymal transition in colorectal cancer","Collagen degradation; Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action",164.8,174.3,177.4,216.2,221.6,220.2,0.7849544072948328,-0.34931923487018207,3.326454477066574E-4,3.4780184155499825,0.018420536565202702,1.7346977235467271,141]
["Medium","P51512-1","Matrix metalloproteinase-16 [OS=Homo sapiens]",1,1,1,1,607,69.5,8.54,2,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","MMP16","ENSCANG00000029811; ENSCATG00000039014; ENSCSAG00000012941; ENSG00000156103; ENSGGOG00000027756; ENSMFAG00000040046; ENSMMUG00000013193; ENSMNEG00000003965; ENSPANG00000010068; ENSRBIG00000031261; ENSRROG00000034264","Matrix metalloproteinases","Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action; MicroRNAs in cancer",89,87.7,92.6,80,68,78.3,1.190013256738842,0.25097764523477906,0.023566994815335727,1.6276957937305128,0.12985962986460223,0.8865258393193378,1417]
["High","P51648","Fatty aldehyde dehydrogenase [OS=Homo sapiens]",24,11,36,11,485,54.8,7.88,85.84,"other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ALDH3A2","ENSG00000072210","Fragile X syndrome; Tryptophan metabolism; Fluoroacetic acid toxicity","RND2 GTPase cycle; RND1 GTPase cycle","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease",1543.3,1623,1644.8,1524.5,1652.8,1604,1.0062326145608935,0.008963856913256449,0.847634027329526,0.07179161734016916,0.9256400678865648,0.033557854482614384,7150]
["High","P51688","N-sulphoglucosamine sulphohydrolase [OS=Homo sapiens]",12,4,8,4,502,56.7,6.95,19.39,"protein metabolism;other metabolic processes","other cytoplasmic organelle","other molecular function","SGSH","ENSG00000181523","Glycosaminoglycan degradation","HS-GAG degradation; MPS IIIA - Sanfilippo syndrome A","Glycosaminoglycan degradation; Metabolic pathways; Lysosome",194.6,195.3,195.5,157.6,160,161.1,1.222895341550031,0.2903009396889838,4.8626163313427314E-6,5.313129995649602,0.006327884719187341,2.1987414413746107,6]
["High","P51797-1","Chloride transport protein 6 [OS=Homo sapiens]",4,2,2,2,869,97.2,6.81,5.36,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","CLCN6","ENSG00000011021","","Signaling by BRAF and RAF1 fusions; Stimuli-sensing channels","",27.1,23.6,22.1,31.1,30.3,24.9,0.8435689455388181,-0.24542210898025868,0.13970652651336612,0.8547833049628866,0.34828498052885143,0.458065253690157,3132]
["Medium","P51825","AF4/FMR2 family member 1 [OS=Homo sapiens]",1,1,1,1,1210,131.3,9.2,2.1,"other biological processes","nucleus","","AFF1","ENSG00000172493","","","Transcriptional misregulation in cancer",63.8,62.2,64.2,66.1,77.4,89.2,0.8173614095401806,-0.29095396454478506,0.10186591611411024,0.9919711047050921,0.2865162366783043,0.5428507618292739,2776]
["High","P51948-1","CDK-activating kinase assembly factor MAT1 [OS=Homo sapiens]",28,6,12,6,309,35.8,6.09,32.73,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","enzyme regulator activity;kinase activity;other molecular function","MNAT1","ENSCANG00000033478; ENSCATG00000030975; ENSCSAG00000014164; ENSG00000020426; ENSMFAG00000000901; ENSMMUG00000001642; ENSNLEG00000013781; ENSPPAG00000033622; ENSPTRG00000006412; ENSRROG00000035712","Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; Eukaryotic transcription initiation; G1 to S cell cycle control","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin D associated events in G1; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Basal transcription factors; Nucleotide excision repair",447.9,441.9,422.1,419.6,413.7,413.9,1.0518762026940347,0.07296492110457918,0.05492302236060645,1.2602455719739272,0.2060735024467156,0.6859778475269186,2081]
["High","P51991-1","Heterogeneous nuclear ribonucleoprotein A3 [OS=Homo sapiens]",52,24,241,22,378,39.6,9.01,505.27,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","transporter activity;nucleic acid binding activity","HNRNPA3; HNRPA3","ENSG00000170144; ENSGGOG00000006130; ENSHGLG00000005451; ENSPPAG00000023768; ENSPTRG00000012676; ENSSTOG00000025125","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Spliceosome; Amyotrophic lateral sclerosis",11168.5,10418.5,10589.5,11188.2,11300.1,11533.5,0.9457612472003245,-0.08045206666462916,0.0686961237091714,1.1630677680235932,0.23089941193336647,0.6365771731651934,2323]
["High","P52306-1","Rap1 GTPase-GDP dissociation stimulator 1 [OS=Homo sapiens]",27,11,23,11,607,66.3,5.31,47.1,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;ER/Golgi","enzyme regulator activity","RAP1GDS1","ENSG00000138698","","RHOT2 GTPase cycle; RHOT1 GTPase cycle","",1068.9,1087.5,1072.7,1022.7,990.1,1008.9,1.0686368600456697,0.09577168541010665,3.2959313516549627E-3,2.482021842456694,0.05016497464663148,1.299599402909875,513]
["High","P52597","Heterogeneous nuclear ribonucleoprotein F [OS=Homo sapiens]",66,18,246,16,415,45.6,5.58,405.27,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPF","ENSG00000169813","MECP2 and associated Rett syndrome","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",5853.6,5790.1,5811.1,5880.9,5800.1,5808.3,0.9980273653033571,-2.8487209619157804E-3,0.7355312114256845,0.13339889375582753,0.8606365500991674,0.0651802139479634,6673]
["High","P52739","Zinc finger protein 131 [OS=Homo sapiens]",23,9,13,9,623,71.4,5.19,20.41,"other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","ZNF131","ENSG00000172262","","SUMOylation of transcription cofactors","",267.2,302.7,277.4,258,288.5,255.2,1.0568791318448296,0.07981039482959869,0.3682867877852079,0.43381386109323083,0.6027212825459869,0.2198834729935215,4771]
["High","P52789","Hexokinase-2 [OS=Homo sapiens]",46,37,122,34,917,102.3,6.05,291.02,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component","kinase activity;other molecular function","HK2","ENSG00000159399","Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis","Glycolysis","Glycolysis / Gluconeogenesis; Fructose and mannose metabolism; Galactose metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Neomycin, kanamycin and gentamicin biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of nucleotide sugars; HIF-1 signaling pathway; Insulin signaling pathway; Type II diabetes mellitus; Carbohydrate digestion and absorption; Shigellosis; Central carbon metabolism in cancer",4662.5,4771.1,4734.1,4419.6,4448.5,4637.6,{"$f":"AVERAGE(T2242:V2242)/AVERAGE(W2242:Y2242)","v":1.0490163412485098},{"$f":"LOG(Z2242,2)","v":0.06903715194240717},{"$f":"TTEST(T2242:V2242,W2242:Y2242,2,2)","v":0.04300453700402714},{"$f":"-LOG10(AB2242)","v":1.3664857236792334},{"$f":"AB2242*7808/AF2242","v":0.17794352142418862},{"$f":"-LOG10(AD2242)","v":0.7497178191855293},1887]
["High","P52907","F-actin-capping protein subunit alpha-1 [OS=Homo sapiens]",67,13,143,11,286,32.9,5.69,385.37,"cell organization and biogenesis","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity","CAPZA1","ENSG00000116489","","MHC class II antigen presentation; Advanced glycosylation endproduct receptor signaling; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production","Endocytosis",5302.4,4812.8,4876.6,4934.7,4950,5110.2,0.9997932630427679,-2.9828921773230704E-4,0.995262941139871,2.0621666912686606E-3,0.9976907233817066,1.0040658721532747E-3,7789]
["High","P53367","Arfaptin-1 [OS=Homo sapiens]",54,16,45,1,373,41.7,6.7,91.35,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","ARFIP1","ENSG00000164144","","","",1533.5,1560.9,1535.9,1469.7,1349.3,1384.4,1.1015606413855452,0.13954891820543733,0.018053302391584078,1.743443343383923,0.11196202150396226,0.9509292688331502,1259]
["High","P53611","Geranylgeranyl transferase type-2 subunit beta [OS=Homo sapiens]",20,7,20,7,331,36.9,5.03,29.64,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RABGGTB","ENSG00000137955","","RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain","",585.6,619.1,648.8,506.2,584.6,537.4,1.1383736641690212,0.18697419117569583,0.06184722842505676,1.2086797577434139,0.21723039115737436,0.663079415783769,2223]
["High","P53667-1","LIM domain kinase 1 [OS=Homo sapiens]",8,3,6,3,647,72.5,6.98,12.9,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","LIMK1","ENSG00000106683; ENSPTRG00000019286; ENSPTRG00000045946","Microtubule cytoskeleton regulation; VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; G13 signaling pathway","Regulation of actin dynamics for phagocytic cup formation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Axon guidance; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Human immunodeficiency virus 1 infection",187.1,194.7,174.3,197.9,209.7,212.2,0.8972249112616972,-0.15645841778151864,0.04563502160885413,1.3407017394889627,0.1841437977891127,0.7348429041852574,1935]
["High","P53778","Mitogen-activated protein kinase 12 [OS=Homo sapiens]",10,3,3,3,367,41.9,6.39,4.87,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","MAPK12","ENSG00000188130","Integrin-mediated cell adhesion; Parkinson's disease pathway; S1P receptor signal transduction; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway","p38MAPK events; Negative regulation of MAPK pathway; VEGFA-VEGFR2 Pathway; Myogenesis; NOD1/2 Signaling Pathway; DSCAM interactions; Activation of PPARGC1A (PGC-1alpha) by phosphorylation","Endocrine resistance; MAPK signaling pathway; Rap1 signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; VEGF signaling pathway; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Leukocyte transendothelial migration; Thermogenesis; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Relaxin signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Proteoglycans in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",78.3,62.2,68,65.3,61.3,65.2,1.087069864442127,0.12044466331389493,0.31838971542957384,0.4970409692142763,0.5557761900456322,0.2551000627282979,4473]
["High","P53985","Monocarboxylate transporter 1 [OS=Homo sapiens]",15,13,93,13,500,53.9,8.66,223.41,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;other molecular function","SLC16A1","ENSG00000155380; ENSG00000281917","Photodynamic therapy-induced HIF-1 survival signaling; Fragile X syndrome","Basigin interactions; Pyruvate metabolism; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)","",7470.8,6816.9,6895.4,6582.2,6018.1,6510.3,1.108447667786464,0.148540659057575,0.06391218619513434,1.1944163266191108,0.22090586534378437,0.6557927528808385,2259]
["High","P54252","Ataxin-3 [OS=Homo sapiens]",12,3,5,3,364,41.8,4.91,7.43,"","","","","","","","",167.2,144.7,156.2,162.5,166.1,150.9,0.9762252346193951,-0.034714050193539146,0.6576655341684828,0.18199491732069295,0.8126368872903171,0.09010346802604563,6319]
["High","P54578","Ubiquitin carboxyl-terminal hydrolase 14 [OS=Homo sapiens]",51,21,101,21,494,56,5.3,239.24,"protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","USP14","ENSG00000101557","","Ub-specific processing proteases","",3978.1,4109.2,3977.9,3930.9,3761.5,3838.1,1.0463726638046917,0.06539675643357751,0.05328984323714931,1.273355557322255,0.2017881163897487,0.6951044136111173,2062]
["High","P54687","Branched-chain-amino-acid aminotransferase, cytosolic [OS=Homo sapiens]",47,16,148,2,386,42.9,5.3,289.85,"cell cycle OR cell proliferation;other metabolic processes","cytosol;mitochondrion","other molecular function","BCAT1","ENSG00000060982","Amino acid metabolism; One-carbon metabolism and related pathways","Branched-chain amino acid catabolism","Cysteine and methionine metabolism; Valine, leucine and isoleucine degradation; Valine, leucine and isoleucine biosynthesis; Pantothenate and CoA biosynthesis; Metabolic pathways; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors",6038.4,5860.4,5958.7,6000.2,5954,6058.4,0.9913893607807868,-0.012476318458745674,0.43523425833339113,0.36127692760310726,0.6559176006691986,0.18315071523159307,5181]
["High","P54764","Ephrin type-A receptor 4 [OS=Homo sapiens]",5,3,3,3,986,109.8,6.61,10.23,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","EPHA4","ENSG00000116106","Spinal cord injury; Gene regulatory network modelling somitogenesis ; Fragile X syndrome; Somitogenesis in the context of spondylocostal dysostosis","EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse","Axon guidance",114.1,110.3,104.9,106.2,126.4,119.7,0.934714731762702,-0.0974019628996165,0.3043688873580258,0.5165997432920867,0.540607887281953,0.2671176223849043,4396]
["High","P54920","alpha-soluble nsf attachment protein [OS=Homo sapiens]",59,15,77,15,295,33.2,5.36,211.67,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","NAPA","ENSG00000105402","Synaptic vesicle pathway; VEGFA-VEGFR2 signaling pathway","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network; COPI-dependent Golgi-to-ER retrograde traffic; Intra-Golgi traffic","Synaptic vesicle cycle",2646.2,2695,2676.6,2551.9,2687,2673.1,1.0133720930232557,0.019164004536224605,0.4788651416018212,0.31978677573870196,0.6906130449994495,0.16076522251455416,5414]
["High","P55061","Bax inhibitor 1 [OS=Homo sapiens]",3,1,2,1,237,26.5,8.54,4.76,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","TMBIM6","ENSG00000139644","","","Pathogenic Escherichia coli infection",150.2,166.4,183.6,98.8,115.5,100.9,1.5869289340101522,0.6662375227245937,0.004940831728586627,2.3061999367583708,0.05944224058059227,1.2259048289001047,649]
["High","P55145","Mesencephalic astrocyte-derived neurotrophic factor [OS=Homo sapiens]",19,4,7,4,182,20.7,8.69,13.77,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","MANF","ENSG00000145050","Orexin receptor pathway","Platelet degranulation","",370.4,287.4,254.8,353.3,278.9,272.8,1.0083977900552485,0.012064861587722702,0.9559026906055611,0.019586315970780175,0.9792296258525611,0.009115455748293182,7622]
["High","P55265-1","Double-stranded RNA-specific adenosine deaminase [OS=Homo sapiens]",49,54,263,54,1226,136,8.65,499.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ADAR","ENSG00000160710","Measles virus infection; Cytosolic DNA-sensing pathway","Interferon alpha/beta signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins","Cytosolic DNA-sensing pathway; Measles; Influenza A; Coronavirus disease",13276.4,13422.1,13296.1,13820.6,14198.2,14318.5,0.9446658147779853,-0.08212404347030253,7.5930236926469215E-3,2.1195852449831705,0.07355623944440096,1.1333804821296256,806]
["High","P55786","puromycin-sensitive aminopeptidase [OS=Homo sapiens]",50,37,153,37,919,103.2,5.72,323.71,"protein metabolism;other metabolic processes;stress response","cytosol;nucleus;other cell component","other molecular function","NPEPPS","ENSG00000141279","","Antigen processing: Ubiquitination & Proteasome degradation","",6731.8,6649.3,6730.8,6799.8,7042.9,6932.3,0.9680818291215404,-0.046799095447092896,0.042752529410284,1.3690381855806721,0.17708846134509149,0.7518097354638484,1885]
["High","P55854","Small ubiquitin-related modifier 3 [OS=Homo sapiens]",20,2,6,1,103,11.6,5.49,17.4,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SUMO3","ENSG00000184900","Exercise-induced circadian regulation","SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; SUMOylation of immune response proteins; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed","Nucleocytoplasmic transport; Fluid shear stress and atherosclerosis",438.5,415.1,401.4,415.1,349.9,413.1,1.0652745946863593,0.09122536033794346,0.3455218948930136,0.461524427219058,0.5824341440683615,0.23475317327980239,4632]
["High","P56270-2","Isoform 2 of Myc-associated zinc finger protein [OS=Homo sapiens]",14,7,19,5,493,51,9.1,47.84,"","","","MAZ","","","","",769.3,666.6,725,764.4,772.1,862.9,0.9006001500375094,-0.15104137685855673,0.14103241296719093,0.8506810635498512,0.3502484352569424,0.45562379625858607,3144]
["High","P56747","Claudin-6 [OS=Homo sapiens]",25,5,20,5,220,23.3,8,42.93,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CLDN6","ENSG00000184697","Epithelial to mesenchymal transition in colorectal cancer","Tight junction interactions","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Pathogenic Escherichia coli infection; Hepatitis C",807,818.1,821.4,664.2,636.2,692.3,1.2277312189491645,0.29599475327144653,8.3666547208617484E-4,3.0774481533184086,0.027798655344888738,1.5559762109315094,235]
["High","P57060","RWD domain-containing protein 2B [OS=Homo sapiens]",5,1,1,1,319,36.3,5.87,4.78,"","","","RWDD2B","ENSG00000156253","","","",77.2,69.2,76.6,53.4,59.8,66.5,{"$f":"AVERAGE(T2370:V2370)/AVERAGE(W2370:Y2370)","v":1.2409571508069004},{"$f":"LOG(Z2370,2)","v":0.31145330129772525},{"$f":"TTEST(T2370:V2370,W2370:Y2370,2,2)","v":0.034330621534826154},{"$f":"-LOG10(AB2370)","v":1.4643183338681083},{"$f":"AB2370*7808/AF2370","v":0.156117351743694},{"$f":"-LOG10(AD2370)","v":0.8065488243703893},1717]
["High","P57081-1","tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 [OS=Homo sapiens]",10,2,2,2,412,45.5,7.11,3.57,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","","WDR4","ENSG00000160193","","tRNA modification in the nucleus and cytosol","",20.3,16.5,13.3,23.2,20.8,22.7,0.7511244377811094,-0.4128761579893767,0.06183641402540819,1.2087557036649825,0.21738798771291631,0.6627644575548212,2221]
["High","P57772","selenocysteine-specific elongation factor [OS=Homo sapiens]",9,5,17,5,596,65.3,8.35,38.67,"protein metabolism;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EEFSEC","ENSG00000132394; ENSG00000284869","","Selenocysteine synthesis","",1592,1641.5,1699.6,1401.3,1404.4,1386.9,1.1766207126842532,0.2346493381204755,1.4424241153030625E-3,2.8409070254318687,0.03433673015940949,1.4642410644849122,328]
["High","P58107","epiplakin [OS=Homo sapiens]",32,43,92,40,5090,555.3,5.6,194.31,"","","","","","","","",2492.3,2543.6,2574.7,2157.3,2117.2,2129.1,1.1884877256543194,0.24912700363450377,1.1480264817863384E-4,3.9400480938535245,0.012991001115634393,1.8863573799321445,69]
["High","P60033","CD81 antigen [OS=Homo sapiens]",18,2,18,2,236,25.8,5.29,45.32,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","CD81","ENSG00000110651","B cell receptor signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; IL-18 signaling pathway; 16p11.2 distal deletion syndrome","Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","B cell receptor signaling pathway; Malaria; Hepatitis C",543.5,520.2,565.8,429.5,414.1,447.5,1.2621020834946945,0.3358286055623825,0.002300652047264044,2.638149059462569,0.042267038082441546,1.373998184854245,425]
["High","P60660","Myosin light polypeptide 6 [OS=Homo sapiens]",39,6,24,5,151,16.9,4.65,59.47,"developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL6","ENSG00000092841","Ciliary landscape","Smooth Muscle Contraction; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; RHO GTPases activate PKNs","Vascular smooth muscle contraction; Tight junction; Oxytocin signaling pathway",944.1,771.4,715,827.5,755.1,729,1.0514362346426718,0.07236135910034129,0.6249339182372855,0.20416590339542845,0.7934120379832074,0.10050121451220978,6150]
["High","P60763","Ras-related C3 botulinum toxin substrate 3 [OS=Homo sapiens]",26,5,33,1,192,21.4,8.15,80.24,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","RAC3","ENSG00000169750","Integrin-mediated cell adhesion; RalA downstream regulated genes; Focal adhesion; MAPK signaling pathway; Microglia pathogen phagocytosis pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Regulation of actin cytoskeleton","RAC3 GTPase cycle; PCP/CE pathway","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Wnt signaling pathway; Axon guidance; VEGF signaling pathway; Focal adhesion; Adherens junction; Natural killer cell mediated cytotoxicity; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Regulation of actin cytoskeleton; Yersinia infection; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer; Choline metabolism in cancer; Viral myocarditis; Fluid shear stress and atherosclerosis",120.4,64.7,82.1,60.2,61,77.4,1.3454179254783485,0.4280543849456784,0.25863520540224794,0.5873123593037349,0.4933847260641954,0.3068142992903691,4093]
["High","P61006","Ras-related protein Rab-8A [OS=Homo sapiens]",31,6,18,3,207,23.7,9.07,30.45,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB8A","ENSG00000167461","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape; Joubert syndrome","Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB geranylgeranylation; Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs; VxPx cargo-targeting to cilium","Autophagy; Endocytosis; AMPK signaling pathway; Tight junction; Pancreatic secretion; Amyotrophic lateral sclerosis; Pathways of neurodegeneration",277.2,246,242.6,225.7,213.7,248.2,1.1137289121582319,0.15539811537210008,0.1561662263384211,0.8064128840362936,0.37141209115150525,0.43014396210699835,3283]
["High","P61088","ubiquitin-conjugating enzyme E2 N [OS=Homo sapiens]",48,6,56,6,152,17.1,6.57,137.06,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2N","ENSG00000177889","IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway; 3q29 copy number variation syndrome","ISG15 antiviral mechanism; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Nonhomologous End-Joining (NHEJ); Aggrephagy; E3 ubiquitin ligases ubiquitinate target proteins; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; Formation of Incision Complex in GG-NER; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Ubiquitin mediated proteolysis; Shigellosis",3315.6,3173.3,3106,3086.5,3127,2980.8,1.043570473010452,0.06152802994639295,0.15212477905559288,0.8178000395260956,0.3654739307280213,0.4371435958463345,3250]
["High","P61158","actin-related protein 3 [OS=Homo sapiens]",58,22,178,18,418,47.3,5.88,454.13,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ACTR3","ENSG00000115091","Physico-chemical features and toxicity-associated pathways","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Clathrin-mediated endocytosis","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",8258.7,8294.4,8411.2,8384.7,8381.1,8435.3,0.990603584764157,-0.01362025312751812,0.184355468771942,0.7343439748343785,0.4054781690623445,0.39203252323083726,3550]
["High","P61289-1","Proteasome activator complex subunit 3 [OS=Homo sapiens]",54,15,134,15,254,29.5,5.95,309.53,"cell cycle OR cell proliferation;protein metabolism;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","HEL-S-283; LOC101359250; LOC103001388; LOC111151323; LOC111166421; Psme3; PSME3","ENSBTAG00000019918; ENSCAFG00000014716; ENSCATG00000043580; ENSCCAG00000025926; ENSCGRG00001014333; ENSCGRG00015000348; ENSECAG00000012620; ENSG00000131467; ENSGGOG00000010707; ENSLAFG00000013446; ENSMLUG00000004084; ENSMMUG00000012685; ENSMNEG00000003232; ENSMPUG00000010027; ENSMUSG00000078652; ENSNVIG00000013505; ENSOARG00000003731; ENSOGAG00000009420; ENSPPAG00000043945; ENSPTRG00000009225; ENSPTRG00000049975; ENSRBIG00000001980; ENSRNOG00000051344; ENSSBOG00000024784; ENSSSCG00000017385; ENSSSCG00005010026; ENSSSCG00015075406; ENSSSCG00025054060; ENSSSCG00030072129; ENSSSCG00035013193; ENSSSCG00040025703; ENSSSCG00045007466; ENSSSCG00050060716; ENSSSCG00055025037; ENSSSCG00060042579; ENSSSCG00065003129; ENSSSCG00070012475; ENSSSUG00005017981; ENSSTOG00000028833; ENSTSYG00000002969; ENSUAMG00000013177; ENSUMAG00000025062","Proteasome degradation; Proteasome degradation; Proteasome degradation; Proteasome degradation","Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Hedgehog ligand biogenesis; Hedgehog 'on' state; Regulation of expression of SLITs and ROBOs; ER-Phagosome pathway; Degradation of beta-catenin by the destruction complex; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Downstream TCR signaling; FCERI mediated NF-kB activation; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; FCERI mediated NF-kB activation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; UCH proteinases; ABC-family proteins mediated transport; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Hedgehog ligand biogenesis; Degradation of beta-catenin by the destruction complex; Downstream TCR signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of RUNX3 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Regulation of RAS by GAPs; Autodegradation of the E3 ubiquitin ligase COP1; Neddylation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Separation of Sister Chromatids; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX3 expression and activity; Regulation of PTEN stability and activity; Antigen processing: Ubiquitination & Proteasome degradation","Proteasome; Antigen processing and presentation; Hepatitis C",3347.3,3445.4,3475.9,3287.3,3481.8,3373.2,1.0124527967029175,0.01785464720704773,0.5712602999294206,0.24316595644124472,0.7557438871312973,0.12162535694654998,5902]
["High","P61326","Protein mago nashi homolog [OS=Homo sapiens]",42,10,73,10,146,17.2,6.11,194.65,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","","MAGOH","ENSG00000162385","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",4258.2,4079.7,4024.7,3706.2,4617.5,4110.7,0.9942256964549956,-0.00835470366768557,0.9343253946052719,0.029501847034764505,0.9693346639752807,0.013526256359974653,7526]
["High","P61803","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [OS=Homo sapiens]",19,2,9,2,113,12.5,7.08,17.53,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity","DAD1","ENSG00000129562","","Asparagine N-linked glycosylation; Maturation of spike protein","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum",339.7,354,369.1,349.6,386.5,366.2,0.9641658350721221,-0.052646785714589334,0.38888135911375005,0.410182874101354,0.619038868901154,0.20828208115868593,4905]
["High","P61966","AP-1 complex subunit sigma-1A [OS=Homo sapiens]",16,2,4,2,158,18.7,5.73,11.33,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","AP1S1","ENSG00000106367","","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","Lysosome; Human immunodeficiency virus 1 infection",109,94.7,99.3,82.2,84.4,99,1.140813253012048,0.19006264701338832,0.13845772864586017,0.85868279712629,0.3463883195344044,0.46043676113298737,3121]
["High","P61978-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein K [OS=Homo sapiens]",65,30,512,1,440,48.5,5.54,787.75,"","","","HNRNPK","","","","",22351.7,22590.5,22698.5,24622.1,23389.7,23848.8,0.9412765827170937,-0.08730939118504359,0.01974112530803756,1.7046280947696384,0.11766313466042538,0.9293595857667674,1310]
["High","P62191","26S proteasome regulatory subunit 4 [OS=Homo sapiens]",64,24,191,22,440,49.2,6.21,407.77,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMC1","ENSG00000100764","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; N-glycan trimming in the ER and Calnexin/Calreticulin cycle","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human papillomavirus infection; Epstein-Barr virus infection; Viral carcinogenesis",6488.8,6375.8,6399.3,6483.3,6297.4,6270.1,1.011185881957713,0.0160482260527113,0.3989807566700487,0.3990480503622462,0.6271877890235031,0.20260240569883417,4967]
["High","P62263","40S ribosomal protein S14 [OS=Homo sapiens]",38,7,101,7,151,16.3,10.05,285.12,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","RPS14","ENSG00000164587","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); rRNA modification in the nucleus and cytosol","Ribosome; Coronavirus disease",3956.5,3502.9,3542.9,3388.7,3818.8,3816.2,0.9980587280132802,-2.8033854162896523E-3,0.9737299443473113,0.011561474273414992,0.9871310575777469,5.6251839014919E-3,7702]
["High","P62306","Small nuclear ribonucleoprotein F [OS=Homo sapiens]",15,1,10,1,86,9.7,4.67,8.85,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","SNRPF","ENSG00000139343","mRNA processing","snRNP Assembly; mRNA Splicing - Major Pathway; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","Spliceosome",288.5,226.3,229.1,239.8,273.2,236.3,0.9927932737221408,-0.01043475379518439,0.9424902905563767,0.02572311515878301,0.9735367361640679,0.011647655841616516,7559]
["High","P62316","Small nuclear ribonucleoprotein Sm D2 [OS=Homo sapiens]",56,6,37,6,118,13.5,9.91,74.8,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","SNRPD2","ENSG00000125743","mRNA processing","mRNA Splicing - Major Pathway; snRNP Assembly; mRNA Splicing - Minor Pathway","Spliceosome",1837.1,1736.3,1507.5,1944.8,1532.4,1478,1.025367290926703,0.03614078181167075,0.8242198372988976,0.08395693709877498,0.9116742441747828,0.04016031433582333,7059]
["High","P62487","DNA-directed RNA polymerase II subunit rpb7 [OS=Homo sapiens]",51,6,18,6,172,19.3,5.54,34.5,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR2G","ENSG00000168002","Pyrimidine metabolism; Eukaryotic transcription initiation","Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; mRNA Splicing - Major Pathway; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Inhibition of DNA recombination at telomere; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","RNA polymerase; Huntington disease",427.5,402.6,393.4,426.7,455.7,441.3,0.9243030898239781,-0.11356208904061374,0.0644402171685436,1.1908430046441727,0.22204290187642917,0.6535631055129157,2266]
["High","P62699","Protein yippee-like 5 [OS=Homo sapiens]",23,2,4,2,121,13.8,7.31,8.83,"cell cycle OR cell proliferation","non-structural extracellular;cytoskeleton;nucleus;other cell component","other molecular function","YPEL5","ENSG00000119801","Ciliary landscape","Neutrophil degranulation","",90.6,98.5,85.6,87.2,81.6,81.5,1.0974830203755492,0.13419861938752412,0.1249475166377588,0.9032723711600656,0.3242240644425459,0.4891547542415108,3009]
["High","P62820","Ras-related protein Rab-1A [OS=Homo sapiens]",78,14,103,5,205,22.7,6.21,234.8,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB1A","ENSG00000138069","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization","Autophagy; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Legionellosis",5517.4,5471.4,5579.6,4801.1,5890.9,5316.3,1.034988099923165,0.04961418001394004,0.586761505715933,0.23153838563231263,0.7652303050993827,0.11620783911936211,5987]
["High","P62851","40S ribosomal protein S25 [OS=Homo sapiens]",37,5,10,5,125,13.7,10.11,15.49,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","other molecular function","RPS25","ENSG00000118181; ENSG00000280831","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",1095.1,994.1,876.4,1333.7,940.5,800.8,0.9644227642276423,-0.052262390182171194,0.8420924695495302,0.07464021632682495,0.9228151582095062,0.03488528034873738,7125]
["High","P62873","Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [OS=Homo sapiens]",52,11,53,6,340,37.4,6,145.37,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","cytoskeletal activity;other molecular function","GNB1","ENSG00000078369","Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells; Estrogen signaling pathway","G alpha (q) signalling events; Thrombin signalling through proteinase activated receptors (PARs); G alpha (i) signalling events; Inactivation, recovery and regulation of the phototransduction cascade; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (12/13) signalling events; Olfactory Signaling Pathway; G alpha (z) signalling events; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Sensory perception of sweet, bitter, and umami (glutamate) taste; Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation; Activation of the phototransduction cascade","Ras signaling pathway; Chemokine signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Olfactory transduction; Phototransduction; Relaxin signaling pathway; Morphine addiction; Alcoholism; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",2311.6,2254.3,2317.4,2189.9,2401.3,2411,0.9830196224043869,-0.02470787988513517,0.6246844402468266,0.20433931140486827,0.7932242819071754,0.10060399979088124,6149]
["High","P62913","60S ribosomal protein L11 [OS=Homo sapiens]",33,6,50,6,178,20.2,9.6,106.77,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL11","ENSG00000142676","Cytoplasmic ribosomal proteins","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",2639.7,2669.1,2436.2,2436.9,2728,2464.3,1.0151785246159493,0.02173345542072018,0.7603990148485376,0.11895845446588055,0.874274113965157,0.05835238027399058,6791]
["High","P62979","Ubiquitin-40S ribosomal protein S27a [OS=Homo sapiens]",63,11,613,11,156,18,9.64,1106.78,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle","other molecular function","RPS27A","ENSG00000143947","Cytoplasmic ribosomal proteins","Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Glycogen synthesis; Cargo recognition for clathrin-mediated endocytosis; InlA-mediated entry of Listeria monocytogenes into host cells; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Stimuli-sensing channels; Negative regulation of MAPK pathway; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oncogene Induced Senescence; ISG15 antiviral mechanism; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Orc1 removal from chromatin; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Regulation of PLK1 Activity at G2/M Transition; Peroxisomal protein import; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of PTEN stability and activity; Downregulation of ERBB4 signaling; Regulation of PTEN localization; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Oxidative Stress Induced Senescence; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Regulation of TP53 Degradation; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; ER Quality Control Compartment (ERQC); Deactivation of the beta-catenin transactivating complex; Circadian Clock; Regulation of signaling by CBL; Metalloprotease DUBs; Regulation of necroptotic cell death; Cyclin D associated events in G1; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Inactivation of CSF3 (G-CSF) signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Regulation of BACH1 activity; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Negative regulators of DDX58/IFIH1 signaling; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Formation of TC-NER Pre-Incision Complex; Modulation by Mtb of host immune system; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Formation of Incision Complex in GG-NER; Iron uptake and transport; Myoclonic epilepsy of Lafora; DNA Damage Recognition in GG-NER; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Ribosome; Ubiquitin mediated proteolysis; Mitophagy; Parkinson disease; Pathways of neurodegeneration; Shigellosis; Kaposi sarcoma-associated herpesvirus infection; Coronavirus disease",20632.1,20235.1,20057.3,19506.8,17752.8,18028.3,1.101949974587568,0.1400587311208689,0.030116413759134146,1.5211967448666628,0.14706001165185703,0.8325054039542621,1599]
["High","P63096-1","Guanine nucleotide-binding protein G(i) subunit alpha-1 [OS=Homo sapiens]",30,9,17,4,354,40.3,5.97,37.11,"cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","Gnai1; GNAI1; LOC101343271; LOC111155312","ENSANAG00000026023; ENSBTAG00000002714; ENSCANG00000034777; ENSCCAG00000031786; ENSCGRG00001015780; ENSCGRG00015010768; ENSCHIG00000023476; ENSCSAG00000011871; ENSFCAG00000007172; ENSG00000127955; ENSGGOG00000008064; ENSLAFG00000022531; ENSLCNG00005007413; ENSMMUG00000023470; ENSMNEG00000038772; ENSMPUG00000018288; ENSMUSG00000057614; ENSPCTG00005000350; ENSPTRG00000019343; ENSSSCG00000015407; ENSSSCG00070000597; ENSSSUG00005001506; ENSTSYG00000026142; ENSTTRG00000006465; ENSVVUG00000019537","Calcium regulation in cardiac cell; G protein signaling pathways; S1P receptor signal transduction; Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Chemokine signaling pathway; G protein signaling pathways; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Common pathways underlying drug addiction; Nicotine activity on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone; G protein signaling pathways; Cell-type dependent selectivity of CCK2R signaling; Chemokine signaling pathway; Purinergic signaling; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Calcium regulation in cardiac cells; Signal transduction of S1P receptor; Serotonin HTR1 group and FOS pathway; Calcium regulation in cardiac cells; G protein signaling pathways","G alpha (i) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Extra-nuclear estrogen signaling; G alpha (i) signalling events; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Adenylate cyclase inhibitory pathway; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion; Adenylate cyclase inhibitory pathway; G alpha (i) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12","Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Axon guidance; Apelin signaling pathway; Gap junction; Platelet activation; Leukocyte transendothelial migration; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Long-term depression; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Gastric acid secretion; Parkinson disease; Cocaine addiction; Morphine addiction; Alcoholism; Pertussis; Chagas disease; Toxoplasmosis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Chemical carcinogenesis",231.3,260.8,258.3,199.5,270.9,230.6,1.0704707560627675,0.0982453836173911,0.5087897608921225,0.2934616372039725,0.712963110740433,0.14693294029726295,5572]
["High","P63167","Dynein light chain 1, cytoplasmic [OS=Homo sapiens]",45,3,7,2,89,10.4,7.4,14.67,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","DYNLL1","ENSG00000088986","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome","Neutrophil degranulation; MHC class II antigen presentation; COPI-mediated anterograde transport; HCMV Early Events; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria","Vasopressin-regulated water reabsorption; Salmonella infection",241,228.7,175.7,238.6,180.9,199.3,1.0429864253393666,0.0607203810379065,0.7528324641575536,0.12330166123264952,0.8704451177465093,0.06025860629419658,6753]
["High","P63279","SUMO-conjugating enzyme ubc9 [OS=Homo sapiens]",6,1,9,1,158,18,8.66,16.67,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2I","ENSG00000103275","Androgen receptor signaling pathway; TGF-beta signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of RNA binding proteins; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Processing of DNA double-strand break ends; Formation of Incision Complex in GG-NER; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)","Nucleocytoplasmic transport; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; MicroRNAs in cancer",679.7,553.1,456.7,678.8,418,440,1.0993623112962,0.13666692638563707,0.6548709582259772,0.18384426894189315,0.8107233933452401,0.09112729527657758,6307]
["High","P68133","Actin, alpha skeletal muscle [OS=Homo sapiens]",40,17,1318,3,377,42,5.39,2621.67,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTA1","ENSG00000143632","Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Malignant pleural mesothelioma","Striated Muscle Contraction","",15659.4,16477.8,16881.4,14796.9,14007.9,14323.1,1.1365867570644523,0.1847078110449516,0.009991209896393679,2.0003819172283603,0.08220375855747296,1.0851083249970177,949]
["High","P68431","Histone H3.1 [OS=Homo sapiens]",57,8,86,1,136,15.4,11.12,147.96,"cell organization and biogenesis","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","H3C1; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8","ENSG00000197153; ENSG00000197409; ENSG00000273983; ENSG00000274750; ENSG00000275379; ENSG00000275714; ENSG00000277775; ENSG00000278828; ENSG00000286522; ENSG00000287080","Histone modifications; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma","Estrogen-dependent gene expression; Transcriptional regulation by small RNAs; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; HATs acetylate histones; Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Amyloid fiber formation; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Transcriptional regulation of granulopoiesis; B-WICH complex positively regulates rRNA expression; SIRT1 negatively regulates rRNA expression; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Late Events; HCMV Early Events; Formation of the beta-catenin:TCF transactivating complex; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Meiotic recombination; Assembly of the ORC complex at the origin of replication; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Interleukin-7 signaling; RMTs methylate histone arginines; PKMTs methylate histone lysines","Neutrophil extracellular trap formation; Alcoholism; Shigellosis; Transcriptional misregulation in cancer; Systemic lupus erythematosus",5596.5,4116.6,3478.4,3966,4248.3,3727.4,1.1046584657125873,0.14360039134964583,0.553618265819271,0.2567895894081433,0.7432344256390763,0.12887418260048936,5816]
["High","P78324","tyrosine-protein phosphatase non-receptor type substrate 1 [OS=Homo sapiens]",12,4,5,4,504,54.9,6.98,7.62,"cell adhesion;stress response;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","SIRPA","ENSG00000198053","Prolactin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Male infertility","Neutrophil degranulation; Cell surface interactions at the vascular wall; Signal regulatory protein family interactions","Osteoclast differentiation",143,146.2,150.7,207.2,153.8,195.9,0.7899084216196803,-0.34024269138688784,0.07615399578643926,1.1183073043768692,0.2464195603400405,0.6083248216270196,2413]
["High","P78362-1","SRSF protein kinase 2 [OS=Homo sapiens]",22,15,40,11,688,77.5,4.97,74.58,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","SRPK2","ENSG00000135250","mRNA processing","Maturation of nucleoprotein","",1275.8,1381.7,1355.5,1317.1,1231.3,1294.2,1.0443449747566753,0.06259835095089648,0.23713830819211973,0.6249982828308672,0.46946650871299966,0.3283953844414054,3944]
["High","P78368","casein kinase I isoform gamma-2 [OS=Homo sapiens]",10,4,6,1,415,47.4,9.06,10.9,"cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK1G2","ENSG00000133275","Hedgehog signaling pathway","Disassembly of the destruction complex and recruitment of AXIN to the membrane; Sphingolipid de novo biosynthesis","Hedgehog signaling pathway",358.6,336.9,331.6,357.3,384.8,374.1,0.920175595771367,-0.12001890004857366,0.061174908295437175,1.2134266730070755,0.21681964773979728,0.6639013654992079,2203]
["High","P78536-1","Disintegrin and metalloproteinase domain-containing protein 17 [OS=Homo sapiens]",15,11,15,11,824,93,5.76,25,"cell adhesion;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM17","ENSG00000151694; ENSPPAG00000038185","Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Notch signaling; Copper homeostasis; Ebola virus infection in host; Soluble ACE2-mediated cell entry of SARS-CoV-2; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Notch signaling pathway","Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; Release of Hh-Np from the secreting cell; Growth hormone receptor signaling; Nuclear signaling by ERBB4; TNF signaling; CD163 mediating an anti-inflammatory response; Regulated proteolysis of p75NTR","Notch signaling pathway; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Coronavirus disease",508.1,503,535.5,510.4,533.3,502,1.0005822604645145,8.3977982308459237E-4,0.983648923204867,0.007159879130631477,0.9935744880185771,2.7995683903210182E-3,7730]
["High","P78563-1","Double-stranded RNA-specific editase 1 [OS=Homo sapiens]",1,1,2,1,741,80.7,9.01,3.57,"cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ADARB1","ENSG00000197381","","C6 deamination of adenosine; Formation of editosomes by ADAR proteins","",78.5,81.7,84.7,74.2,63,67.1,1.1987273617229564,0.2615035698307507,0.022181342999576803,1.6540121624407815,0.1252291584531422,0.9022945378914566,1383]
["High","P81605","Dermcidin [OS=Homo sapiens]",16,2,3,2,110,11.3,6.54,2.57,"protein metabolism;stress response;other biological processes","non-structural extracellular","other molecular function","DCD","ENSG00000161634","","Antimicrobial peptides","",54.6,50.1,55.6,49.6,51.9,62.3,0.9786324786324787,-0.031160931486460472,0.7976232429439566,0.09820219906045896,0.8955769745335653,0.04789708074906317,6954]
["High","P82912-1","28S ribosomal protein S11, mitochondrial [OS=Homo sapiens]",29,3,6,3,194,20.6,10.81,19.37,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS11","ENSG00000181991","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",320.1,303.6,274.7,290.9,300.4,291.8,1.0173253312195678,0.02478111349396414,0.7268653901290929,0.1385460096870576,0.8551099843495492,0.06797802267046495,6637]
["Medium","P83369","U7 snRNA-associated Sm-like protein LSm11 [OS=Homo sapiens]",3,1,1,1,360,39.5,10.99,2.63,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","LSM11","ENSG00000155858","","RNA Polymerase II Transcription Termination; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","",30.9,19.6,19.7,27.7,24.4,27,0.8874841972187106,-0.17220666416823088,0.48734979452949034,0.31215921270126956,0.6975668553045391,0.15641416296699484,5455]
["High","P84022","Mothers against decapentaplegic homolog 3 [OS=Homo sapiens]",10,4,8,1,425,48.1,7.15,23.23,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","SMAD3","ENSG00000166949","Androgen receptor signaling pathway; Cell cycle; AGE/RAGE pathway; Adipogenesis; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Ovarian infertility; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularisation processes; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; TGF-beta receptor signaling; DNA damage response (only ATM dependent)","Ub-specific processing proteases; Interleukin-37 signaling; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX3 regulates BCL2L11 (BIM) transcription; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates CDKN1A transcription; NOTCH4 Intracellular Domain Regulates Transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer","FoxO signaling pathway; Cell cycle; Endocytosis; Cellular senescence; Wnt signaling pathway; TGF-beta signaling pathway; Apelin signaling pathway; Hippo signaling pathway; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Th17 cell differentiation; AGE-RAGE signaling pathway in diabetic complications; Hepatitis B; Human T-cell leukemia virus 1 infection; Pathways in cancer; Colorectal cancer; Pancreatic cancer; Chronic myeloid leukemia; Hepatocellular carcinoma; Gastric cancer; Inflammatory bowel disease; Diabetic cardiomyopathy",183.5,190.7,198.7,232.6,217.6,240.5,0.829448385695671,-0.2697758858794396,0.0080780547069994,2.0926932099841156,0.07608377702322233,1.1187079358757537,829]
["High","P84103","Serine/arginine-rich splicing factor 3 [OS=Homo sapiens]",43,9,79,8,164,19.3,11.65,141.64,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SRSF3","ENSG00000112081","mRNA processing","mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection",3239.5,3114.6,3184.9,3026.4,2950.1,3123.2,1.0482763168016527,0.06801904925671227,0.07676774717094664,1.1148212040275451,0.24717631748896965,0.6069931423071923,2425]
["High","P86397","Hydroxyacyl-thioester dehydratase type 2, mitochondrial [OS=Homo sapiens]",17,1,2,1,168,18.5,8.92,5.04,"other metabolic processes","mitochondrion;nucleus","other molecular function","HTD2","ENSG00000255154","Mitochondrial fatty acid synthesis pathway","Fatty acyl-CoA biosynthesis","Fatty acid biosynthesis; Metabolic pathways; Fatty acid metabolism",28,34,29.3,29.7,28.1,31.8,1.0189732142857144,0.027116127926618085,0.8019107802044176,0.09587394820004017,0.8985819994024243,0.04644228554101157,6968]
["High","P98171-1","Rho GTPase-activating protein 4 [OS=Homo sapiens]",7,5,7,5,946,105,6.34,7.93,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","ARHGAP4","ENSG00000089820","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle","",414.1,399.1,411.2,432.1,412.3,407.8,0.9777990736304105,-0.03239005635399963,0.34998664340349117,0.4559485293835696,0.586793152607786,0.2315149626576655,4657]
["High","P98198-1","Phospholipid-transporting ATPase ID [OS=Homo sapiens]",4,3,6,3,1209,137.4,7.01,5.74,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi","transporter activity;other molecular function","ATP8B2","ENSG00000143515; ENSPPAG00000034141; ENSPTRG00000001382","Mesodermal commitment pathway; Complement system in neuronal development and plasticity","Ion transport by P-type ATPases","",175.5,176.4,159.4,162.2,171.7,174.8,1.005111067426774,0.007354931824314372,0.9032991955450062,0.044168376538883836,0.9541342152077121,0.020390530092298714,7392]
["High","Q00341-1","Vigilin [OS=Homo sapiens]",48,53,183,52,1268,141.4,6.87,403.1,"other metabolic processes;transport","non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","HDLBP","ENSG00000115677","","HDL clearance","",6767,6989,6903,6906.4,7166.8,6984.7,0.9810569904881303,-0.027591148548410813,0.2568999262238466,0.5902360204537042,0.49151546776667343,0.30846281056833963,4081]
["High","Q00688","peptidyl-prolyl cis-trans isomerase FKBP3 [OS=Homo sapiens]",54,10,29,10,224,25.2,9.28,56.54,"protein metabolism;other metabolic processes","nucleus","other molecular function","FKBP3","ENSG00000100442","","","",1431.8,1445.4,1381.5,1648.9,1416.5,1349.8,0.964554267077369,-0.05206568643051575,0.6036950327479984,0.21918239754226915,0.777573542675086,0.10925852491523722,6062]
["High","Q01081","Splicing factor U2AF 35 kDa subunit [OS=Homo sapiens]",47,8,66,8,240,27.9,8.81,83.97,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","U2AF1","ENSG00000160201","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","Spliceosome; Shigellosis",2354.9,2269,2310.2,2320.7,2166.2,2260.8,1.0276242275145604,0.03931280907565414,0.2929776391872354,0.533165524861509,0.5308817374736445,0.2750022142912414,4309]
["High","Q01082-1","Spectrin beta chain, non-erythrocytic 1 [OS=Homo sapiens]",69,146,748,14,2364,274.4,5.57,1717.53,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SPTBN1","ENSG00000115306; ENSPPAG00000020369; ENSPTRG00000011924","TGF-beta signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways","RHOV GTPase cycle; RHOU GTPase cycle; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Signaling by FLT3 fusion proteins; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Nephrin family interactions; Interaction between L1 and Ankyrins","",30537.8,31493.2,31026.5,30518,30612.4,30555.3,1.0149619842570872,0.02142569179381654,0.17435587358715718,0.7585634178118079,0.39311887408851376,0.40547610470263346,3463]
["High","Q01518-1","adenylyl cyclase-associated protein 1 [OS=Homo sapiens]",52,23,219,1,475,51.9,8.06,510.69,"cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CAP1","ENSG00000131236","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity","Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling","",206.1,199.6,197,196.5,199.9,201.9,1.007354170148755,0.010571001799492663,0.6639338873828322,0.17787516426800487,0.8159917822580126,0.08831421494463128,6353]
["High","Q01780","exosome component 10 [OS=Homo sapiens]",34,27,72,27,885,100.8,8.46,142.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","EXOSC10","ENSG00000171824","","Major pathway of rRNA processing in the nucleolus and cytosol","RNA degradation",2882.4,2950,2960.5,3218.3,3295.4,3227.2,0.9026783972733524,-0.14771601338343793,0.00079086332640649,3.101898562919596,0.02684809066339945,1.5710865942785537,230]
["High","Q01844","RNA-binding protein EWS [OS=Homo sapiens]",7,4,36,4,656,68.4,9.33,89.93,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","EWSR1","ENSG00000182944","VEGFA-VEGFR2 signaling pathway","","Transcriptional misregulation in cancer",1247.6,1430.7,1399.1,1561.1,1298.1,1445.3,0.947241259147404,-0.07819617284049987,0.4692358227338718,0.328608840073608,0.6830338001316315,0.1655578045945339,5364]
["High","Q01970-1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [OS=Homo sapiens]",34,32,82,32,1234,138.7,5.9,165.67,"other metabolic processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","other molecular function","PLCB3","ENSG00000149782","Alzheimer's disease and miRNA effects; S1P receptor signal transduction; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; GPR40 pathway; MAPK cascade; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; Calcium regulation in cardiac cells","G alpha (q) signalling events; Synthesis of IP3 and IP4 in the cytosol; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Inositol phosphate metabolism; Metabolic pathways; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Apelin signaling pathway; Gap junction; Platelet activation; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Pathways in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis",3322.3,3254.7,3212.8,3190.4,2968.5,3310.1,1.033878973492449,0.048067312769378506,0.366202451360326,0.4362787528560059,0.600568943545773,0.2214371296718812,4761]
["High","Q02127","Dihydroorotate dehydrogenase (Quinone), mitochondrial [OS=Homo sapiens]",17,5,9,5,395,42.8,9.67,20.63,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","DHODH","ENSG00000102967","Pyrimidine metabolism","Pyrimidine biosynthesis","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",320.4,281.8,303.3,315.7,282.7,325.3,0.9802966331059866,-0.028709726928443462,0.7401363882103091,0.13068824352677036,0.863179226160731,0.06389902021616276,6695]
["High","Q02318","Sterol 26-hydroxylase, mitochondrial [OS=Homo sapiens]",10,5,7,5,531,60.2,8.9,11.54,"other metabolic processes","other membranes;mitochondrion","other molecular function","CYP27A1","ENSG00000135929","Vitamin D metabolism; PPAR signaling pathway; Oxidation by cytochrome P450; Vitamin D-sensitive calcium signaling in depression; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Metapathway biotransformation Phase I and II","Endogenous sterols; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol; Defective CYP27A1 causes CTX","Primary bile acid biosynthesis; Metabolic pathways; PPAR signaling pathway; Cholesterol metabolism",350,330.9,332.3,415.5,473,409,0.7808863198458574,-0.3568155564201045,0.011155257154527327,1.9525204137705554,0.08615256959698256,1.064731764702921,1011]
["High","Q02880","DNA topoisomerase 2-beta [OS=Homo sapiens]",39,55,218,39,1626,183.2,8,460.98,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP2B","ENSG00000077097","","SUMOylation of DNA replication proteins","Platinum drug resistance",5198,5431.8,5407.2,5935.7,6314.1,6231.4,0.8677466831158153,-0.20465414939582657,0.003981692310979422,2.3999323035267777,0.05473424923261854,1.2617408345791612,568]
["High","Q03013-1","glutathione S-transferase mu 4 [OS=Homo sapiens]",46,9,31,2,218,25.5,5.9,59.38,"other metabolic processes","non-structural extracellular;cytosol;other cell component","other molecular function","GSTM4","ENSG00000168765","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II","Glutathione conjugation; Biosynthesis of maresin conjugates in tissue regeneration (MCTR)","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis",63.7,55.4,65.2,64.7,60.9,64.6,0.9689800210304943,-0.045461175229850145,0.5826408490365111,0.23459907019026296,0.7629145982352975,0.11752407487736678,5963]
["High","Q03135","Caveolin-1 [OS=Homo sapiens]",27,4,6,4,178,20.5,6.02,10.73,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","CAV1","ENSG00000105974","Androgen receptor signaling pathway; Integrin-mediated cell adhesion; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus infection in host; Acute viral myocarditis; EGF/EGFR signaling pathway; Congenital generalized lipodystrophy (CGL)","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RND1 GTPase cycle; RHOH GTPase cycle; Basigin interactions; Triglyceride catabolism; RHOD GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; NOSTRIN mediated eNOS trafficking; RND3 GTPase cycle; Disassembly of the destruction complex and recruitment of AXIN to the membrane; FOXO-mediated transcription of cell cycle genes; VEGFR2 mediated vascular permeability; eNOS activation","Endocytosis; Focal adhesion; Prion disease; Bacterial invasion of epithelial cells; Proteoglycans in cancer; Viral myocarditis; Fluid shear stress and atherosclerosis",433.6,432.3,426.7,431,405,409.1,1.0381495462211874,0.054014279968914405,0.13059036948102537,0.884088849366193,0.3340922689737372,0.47613357399040057,3052]
["High","Q03426","mevalonate kinase [OS=Homo sapiens]",15,4,12,4,396,42.4,6.46,11.91,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","MVK","ENSG00000110921","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Terpenoid backbone biosynthesis; Metabolic pathways; Peroxisome",281.5,296.3,290.5,292.5,291.9,287,0.9964425063116824,-0.005141529413512483,0.8348378348530948,0.07839787693339241,0.9182157789171664,0.03705524844891767,7099]
["High","Q04726","Transducin-like enhancer protein 3 [OS=Homo sapiens]",20,13,23,10,772,83.4,7.2,57.7,"cell-cell signaling;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","TLE3","ENSG00000140332","White fat cell differentiation","Estrogen-dependent gene expression; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes","Wnt signaling pathway; Notch signaling pathway",893.5,898.8,897.3,895.4,944,917.8,0.9754823734223125,-0.035812290741906616,0.18605774085984936,0.730352256613781,0.4084168795709035,0.38889631714092593,3557]
["High","Q04727-1","Transducin-like enhancer protein 4 [OS=Homo sapiens]",16,10,20,2,773,83.7,7.5,44.85,"cell-cell signaling;signal transduction;other biological processes","nucleus;other cell component","other molecular function","TLE4","ENSG00000106829","","Formation of the beta-catenin:TCF transactivating complex; NOTCH1 Intracellular Domain Regulates Transcription; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes","Wnt signaling pathway; Notch signaling pathway",146.8,156.6,172.2,162.4,138.8,155.2,1.0420683610867658,0.059449923456973905,0.5633639699176503,0.2492109318733401,0.7499992970361489,0.12493914366625275,5865]
["High","Q05086","Ubiquitin-protein ligase E3A [OS=Homo sapiens]",27,22,39,22,875,100.6,5.22,96.32,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE3A","ENSG00000114062","Androgen receptor signaling pathway; MECP2 and associated Rett syndrome; Prader-Willi and Angelman syndrome; Synaptic signaling pathways associated with autism spectrum disorder","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis; Human papillomavirus infection; Viral carcinogenesis",1443.9,1502.4,1491.2,1375.7,1394.9,1382.5,1.0684789675182393,0.09555850953653564,0.007252212704596426,2.1395294667003832,0.07158694917508078,1.1451661455394246,791]
["High","Q05519","serine/arginine-rich splicing factor 11 [OS=Homo sapiens]",28,15,76,15,484,53.5,10.52,131.75,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","SRSF11","ENSG00000116754","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",4615.8,4466.5,4525,4439.4,4453.4,4532.7,1.0135413951063275,0.01940501262824062,0.310663056306789,0.5077103894745336,0.5471818505850233,0.2618683161152327,4433]
["High","Q05932-1","Folylpolyglutamate synthase, mitochondrial [OS=Homo sapiens]",13,5,5,5,587,64.6,7.94,9.7,"cell cycle OR cell proliferation;other metabolic processes;developmental processes","other membranes;cytosol;mitochondrion;other cell component","other molecular function","FPGS","ENSG00000136877","Fluoropyrimidine activity","","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance",91.2,116.3,109.4,93.2,81.9,90.4,1.1935969868173257,0.2553157986907176,0.10554463398447828,0.9765638418463375,0.292438787136553,0.5339650259610397,2818]
["High","Q06203","amidophosphoribosyltransferase [OS=Homo sapiens]",43,16,53,16,517,57.4,6.76,119.08,"cell cycle OR cell proliferation;other metabolic processes;transport;developmental processes;other biological processes","cytosol","other molecular function","PPAT","ENSG00000128059","Fluoropyrimidine activity; Metabolic reprogramming in colon cancer","Purine ribonucleoside monophosphate biosynthesis","Purine metabolism; Alanine, aspartate and glutamate metabolism; Metabolic pathways",1749,1709.4,1786.1,1677.8,1750.9,1759,1.0109489754611871,0.015710183485468883,0.6074905675359703,0.21646046093768553,0.7802741160258029,0.10775279966349127,6079]
["High","Q06546","GA-binding protein alpha chain [OS=Homo sapiens]",27,8,23,8,454,51.3,4.97,65,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GABPA","ENSG00000154727","Energy metabolism; Allograft rejection; Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression; Malignant pleural mesothelioma","Transcriptional activation of mitochondrial biogenesis","",708.6,708.1,691.6,780,731.6,743.2,0.9350274968955119,-0.09691930309404506,0.0353238010381651,1.4519325700695145,0.15851048189999603,0.7999420136934788,1740]
["High","Q06787","synaptic functional regulator FMR1 [OS=Homo sapiens]",16,10,25,2,632,71.1,7.42,45.38,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","FMR1","ENSG00000102081","Serotonin and anxiety; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome","","",842.8,893.8,838.8,889,881.5,868.1,0.9760479041916167,-0.03497613824297479,0.3236186843150017,0.489966412088655,0.5606422647285407,0.2513141655009971,4507]
["High","Q07065","Cytoskeleton-associated protein 4 [OS=Homo sapiens]",67,40,173,40,602,66,5.92,454.28,"","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","","CKAP4","ENSG00000136026","","Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RND2 GTPase cycle; RND3 GTPase cycle; Surfactant metabolism","Protein processing in endoplasmic reticulum",8294.2,8302.3,8450.9,8886.8,8626.8,8541.2,0.9613353393616532,-0.056888325652730026,0.04404471307442192,1.356106214843418,0.1805255221444023,0.7434613901964207,1905]
["High","Q07820","Induced myeloid leukemia cell differentiation protein Mcl-1 [OS=Homo sapiens]",49,10,31,10,350,37.3,5.66,88.8,"stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","transporter activity;other molecular function","MCL1","ENSG00000143384","Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-Akt signaling pathway; MicroRNA network associated with chronic lymphocytic leukemia; Host-pathogen interaction of human coronaviruses - apoptosis; Malignant pleural mesothelioma","Interleukin-4 and Interleukin-13 signaling","PI3K-Akt signaling pathway; Apoptosis; JAK-STAT signaling pathway; MicroRNAs in cancer",800.4,884.6,953.3,829.5,792,816.9,1.0819799868766404,0.11367381422863872,0.21746552302210698,0.6626095862868666,0.44706972189484234,0.34962474202923,3798]
["High","Q07954","prolow-density lipoprotein receptor-related protein 1 [OS=Homo sapiens]",19,65,111,65,4544,504.3,5.39,219.85,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","LRP1","ENSG00000123384","Alzheimer's disease and miRNA effects; Regulation of Wnt / B-catenin signaling by small molecule compounds; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Alzheimer's disease","Retinoid metabolism and transport; Scavenging of heme from plasma","Cholesterol metabolism; Alzheimer disease; Malaria",3551.6,3604,3598,3980.1,3983.7,4102.8,0.8911872441284208,-0.16619951185525697,5.5283800000725325E-4,3.257402112836706,0.02333275191381964,1.6320340365810844,185]
["High","Q08345-1","Epithelial discoidin domain-containing receptor 1 [OS=Homo sapiens]",1,1,1,1,913,101.1,6.83,3.57,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","DDR1","ENSG00000137332; ENSG00000204580; ENSG00000215522; ENSG00000230456; ENSG00000234078; ENSPPAG00000026163; ENSPTRG00000017942","Interactions between LOXL4 and oxidative stress pathway","Non-integrin membrane-ECM interactions","",60.1,58.7,67.1,99.3,65.5,79.6,0.7606382978723404,-0.39471751489924806,0.12682966184516442,0.8967791654669285,0.32725908780140245,0.485108284495461,3026]
["High","Q08623","Pseudouridine-5'-phosphatase [OS=Homo sapiens]",12,2,7,2,228,25.2,5.31,11.08,"other metabolic processes","cytosol","other molecular function","PUDP","ENSG00000130021","","Pyrimidine salvage","",169,181.3,164.7,156.9,154.9,165.3,1.0794382728987633,0.110280745973638,0.09923056893491856,1.0033545186255075,0.28328785456813316,0.5477720446363216,2735]
["High","Q08AD1","Calmodulin-regulated spectrin-associated protein 2 [OS=Homo sapiens]",15,15,19,15,1489,168,6.8,35.55,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi","cytoskeletal activity;other molecular function","CAMSAP2","ENSG00000118200","","","",482.4,534.6,521.2,546.3,501.6,495.8,0.9964371315670142,-0.005149311235687308,0.9385662495097689,0.02753506690938346,0.971926429200567,0.012366608120522095,7540]
["High","Q09028","Histone-binding protein RBBP4 [OS=Homo sapiens]",38,15,119,8,425,47.6,4.89,322.27,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBBP4","ENSG00000162521","Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Malignant pleural mesothelioma","RNA Polymerase I Transcription Initiation; HCMV Early Events; Transcriptional Regulation by E2F6; G1/S-Specific Transcription; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1","Cellular senescence",2446.2,2449.6,2440.7,2451.7,2466.7,2544.6,0.9830497119120996,-0.024663720726751947,0.21845196548673923,0.6606440434414577,0.44827147083323515,0.348458899889414,3805]
["Medium","Q09328","Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A [OS=Homo sapiens]",1,1,1,1,741,84.5,8.12,2.01,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","MGAT5","ENSG00000152127","","N-Glycan antennae elongation; Maturation of spike protein","N-Glycan biosynthesis; Metabolic pathways",71.8,64.4,63.9,53.9,60.8,56.3,1.1701754385964913,0.2267248421324811,0.040841436349663286,1.3888989926438062,0.1726529155485495,0.7628260834254122,1847]
["High","Q0VG06","Fanconi anemia core complex-associated protein 100 [OS=Homo sapiens]",8,4,5,4,881,93.4,5.29,13.18,"DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","nucleic acid binding activity","FAAP100","ENSG00000185504","DNA repair pathways, full network","Fanconi Anemia Pathway","Fanconi anemia pathway",152.4,157.8,154.8,151.4,132.7,140.6,1.094890510948905,0.13078660753535418,0.07585588115465709,1.1200107424448225,0.2458624823808894,0.6093077377845304,2409]
["High","Q10589","bone marrow stromal antigen 2 [OS=Homo sapiens]",22,4,16,4,180,19.8,5.6,37.57,"stress response;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","BST2","ENSG00000130303","Ebola virus infection in host; Host-pathogen interaction of human coronaviruses - MAPK signaling","Neutrophil degranulation; Interferon alpha/beta signaling","Herpes simplex virus 1 infection; Human immunodeficiency virus 1 infection",573.4,532.4,524.9,853.7,835.5,819.3,0.650069762806458,-0.6213335443551302,8.4787302209670225E-5,4.071669183040282,0.01141412509746733,1.942557371944583,58]
["High","Q12767","Transmembrane protein 94 [OS=Homo sapiens]",2,2,2,2,1356,151.1,6.44,7.02,"","other membranes","","TMEM94","ENSG00000177728","","","",52.9,53.1,47,48.9,50,43.9,1.0714285714285714,0.09953567355091437,0.28297879134456877,0.5482461126989561,0.5189052143772647,0.28491196514262446,4258]
["High","Q12797","Aspartyl/Asparaginyl beta-hydroxylase [OS=Homo sapiens]",32,18,71,18,758,85.8,5.01,161.12,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","ASPH","ENSG00000198363","","Stimuli-sensing channels; Ion homeostasis","Calcium signaling pathway; Cardiac muscle contraction",2459.7,2491.3,2520,2415.3,2360.7,2398.9,1.0412688678587856,0.058342637554502606,0.014227827397459524,1.8468614120261486,0.09892330927815134,1.004701363628971,1123]
["High","Q12824-1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [OS=Homo sapiens]",43,14,64,14,385,44.1,6.23,125.24,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101347788; LOC111142756; Smarcb1; SMARCB1","ENSCAFG00000014105; ENSCATG00000029590; ENSCCAG00000036123; ENSCHIG00000019816; ENSCSAG00000011285; ENSDLEG00000015913; ENSECAG00000007797; ENSG00000099956; ENSG00000275837; ENSHGLG00000019077; ENSMFAG00000040790; ENSMLUG00000004975; ENSMMUG00000009098; ENSMNEG00000033936; ENSMUSG00000000902; ENSPANG00000026464; ENSPPAG00000028391; ENSRBIG00000027964; ENSRFEG00010017090; ENSRROG00000030710; ENSSBOG00000031674; ENSSSCG00000010070; ENSSSCG00070020965; ENSSSUG00005014167; ENSSTOG00000012408; ENSTSYG00000008262; ENSUAMG00000010813","TNF-alpha NF-kB signaling pathway; Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation","RMTs methylate histone arginines; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",1546.8,1456.8,1489,1584.6,1512.9,1572.4,0.9620334482537102,-0.05584103998678358,0.1609764741585888,0.7932375891213228,0.37665697040163654,0.42405399111748016,3337]
["High","Q12851","Mitogen-activated protein kinase kinase kinase kinase 2 [OS=Homo sapiens]",8,5,7,5,820,91.5,6.34,12.27,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","kinase activity;other molecular function","MAP4K2","ENSG00000168067","TNF-alpha signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma","","MAPK signaling pathway",100.3,100,106.1,105.5,116.1,107.3,0.9315901489814533,-0.10223271091044522,0.12177119296590642,0.9144554392535802,0.31862918052205,0.496714453395576,2984]
["High","Q12887","Protoheme IX farnesyltransferase, mitochondrial [OS=Homo sapiens]",4,1,1,1,443,48.9,9.19,2.28,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","COX10","ENSG00000006695","Mitochondrial complex IV assembly","Heme biosynthesis","Oxidative phosphorylation; Porphyrin metabolism; Metabolic pathways; Biosynthesis of cofactors; Thermogenesis",20,26.5,29.3,18,19.1,20.7,1.3114186851211074,0.391128355670413,0.10423933621305162,0.9819683628358277,0.2909906103509142,0.5361210245487195,2797]
["High","Q12906-7","Isoform 7 of Interleukin enhancer-binding factor 3 [OS=Homo sapiens]",68,50,542,3,898,95.7,8.81,1315.87,"","","","ILF3","","","","",23675.7,23560.5,23608.3,24101.6,23152.1,23981,0.9945223325149121,-7.924326999017588E-3,0.6872608727364373,0.16287838072118216,0.8311853925536095,0.08030209777656075,6456]
["High","Q12959","Disks large homolog 1 [OS=Homo sapiens]",24,18,28,16,904,100.4,5.76,72.85,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","DLG1","ENSG00000075711","Brain-derived neurotrophic factor (BDNF) signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Disruption of postsynaptic signaling by CNV; 3q29 copy number variation syndrome","Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; NrCAM interactions; Activation of Ca-permeable Kainate Receptor","Hippo signaling pathway; Tight junction; T cell receptor signaling pathway; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Viral carcinogenesis",1393.6,1399.6,1400.8,1442.2,1413.4,1433.8,0.9777591271506503,-0.032448996648628624,0.022782550389734715,1.6423976604944086,0.12751695587315318,0.8944320634453895,1395]
["High","Q12974","Protein tyrosine phosphatase type IVA 2 [OS=Homo sapiens]",19,3,6,2,167,19.1,8.37,8.28,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PTP4A2","ENSG00000184007","","RAB geranylgeranylation","",227.3,220.3,243,219.8,234.3,230.5,1.0087642418930762,0.012589041843548742,0.8147421005985539,0.08897984158155338,0.9063265880429562,0.04271527933513111,7019]
["High","Q12999","Tetraspanin-31 [OS=Homo sapiens]",3,1,2,1,210,23,7.97,5.24,"other biological processes","plasma membrane;other membranes","","TSPAN31","ENSG00000135452","","","",113.7,110.5,123.8,104.1,108,123.8,1.0360226257814826,0.05105551050159222,0.6069007634690256,0.21688231617541465,0.7797731053424636,0.10803174786409568,6077]
["High","Q13045-1","protein flightless-1 homolog [OS=Homo sapiens]",36,36,80,36,1269,144.7,6.05,191.17,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLII","ENSG00000177731; ENSG00000284571","VEGFA-VEGFR2 signaling pathway","","",3685.2,3673.3,3782.2,3680,3707.7,3631,1.0110720865437848,0.01588586093205836,0.3788408610846407,0.42154318493133586,0.6111548436671229,0.2138487419171129,4840]
["High","Q13111-1","Chromatin assembly factor 1 subunit A [OS=Homo sapiens]",25,17,31,17,956,106.9,5.94,52.65,"","","","","","","","",1149.8,1253.2,1265.6,1497.2,1402.2,1501.9,0.8335264580919273,-0.2627001004120945,0.007581388240937412,2.120251262682487,0.07353475700029728,1.1335073383917198,805]
["High","Q13123","Protein Red [OS=Homo sapiens]",31,14,58,14,557,65.6,6.64,127.66,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","IK","ENSG00000113141","","","",2606.5,2965.4,3141.7,3251.5,3080.8,2900.9,0.943724819130962,-0.08356184965451757,0.4072078992247094,0.3901838059256488,0.6342468137136507,0.19774170588006718,5013]
["High","Q13136","Liprin-alpha-1 [OS=Homo sapiens]",23,27,39,22,1202,135.7,6.29,100.62,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;other cell component","","PPFIA1","ENSG00000131626","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",2004.8,2197.7,2101.5,2109.1,1934.8,2052.2,1.034103771263595,0.048380965899932994,0.41188811983787593,0.38522073429573567,0.6379731084495408,0.19519762707525085,5041]
["High","Q13158","FAS-associated death domain protein [OS=Homo sapiens]",48,7,28,7,208,23.3,5.69,60.07,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","FADD","ENSG00000168040","TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor (RLR) pathway; VEGFA-VEGFR2 signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Alzheimer's disease; Toll-like receptor signaling pathway","Regulation of TNFR1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL  signaling; TLR3-mediated TICAM1-dependent programmed cell death; TNFR1-induced proapoptotic signaling; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis","Platinum drug resistance; Apoptosis; Apoptosis; Necroptosis; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Alcoholic liver disease; Alzheimer disease; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Salmonella infection; Chagas disease; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer",779.8,821,808,874.7,886.1,856.1,0.92047842867515,-0.11954418233775443,0.009795896292575934,2.008955821321968,0.08162898426086755,1.0881556075511107,937]
["High","Q13206","probable ATP-dependent RNA helicase DDX10 [OS=Homo sapiens]",22,18,36,18,875,100.8,8.63,70.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX10","ENSG00000178105","","","",1465.6,1537.5,1618.8,1569.5,1632.9,1658.6,0.9508125900020572,-0.07276708831160272,0.1971175965086851,0.7052746049163336,0.42074745586107526,0.3759785013980963,3658]
["High","Q13257-1","Mitotic spindle assembly checkpoint protein MAD2A [OS=Homo sapiens]",35,8,25,8,205,23.5,5.08,53.29,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD2L1","ENSANAG00000022503; ENSCANG00000042550; ENSCATG00000040684; ENSCCAG00000030445; ENSG00000164109; ENSGGOG00000002516; ENSMLEG00000036707; ENSMMUG00000054168; ENSMNEG00000040691; ENSPANG00000019721; ENSPPAG00000028274; ENSPTRG00000016401; ENSRBIG00000035049; ENSRROG00000029952; ENSSBOG00000031396","Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; Cell cycle","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection",1299.5,1277,1323.5,1371.3,1604.7,1469.5,0.8772916432347317,-0.18887156886030776,0.05781445552525588,1.2379635600234487,0.2112378421811876,0.6752282775288827,2137]
["High","Q13283","Ras GTPase-activating protein-binding protein 1 [OS=Homo sapiens]",45,15,98,14,466,52.1,5.52,224.81,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","G3BP1","ENSG00000145907","","","",4594.7,4600.3,4523,4686.6,4104.8,4375.9,1.041823304701799,0.05911061442401072,0.34077217886302763,0.46753586889205434,0.5766686546516081,0.23907365441849363,4614]
["High","Q13362","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [OS=Homo sapiens]",13,7,13,4,524,61,6.87,26.83,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","PPP2R5C","ENSG00000078304","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)","Platelet sensitization by LDL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF activation; Negative regulation of MAPK pathway; CTLA4 inhibitory signaling","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; Dopaminergic synapse; Human papillomavirus infection",429.1,399.8,414.6,413,424.2,421.6,0.9878455672068635,-0.017642576194155185,0.6054748436922701,0.2179038962411443,0.7789664820479889,0.10848122907297608,6069]
["High","Q13367","AP-3 complex subunit beta-2 [OS=Homo sapiens]",23,20,42,15,1082,119,5.59,85.06,"transport","other membranes;ER/Golgi;other cell component","","AP3B2","ENSG00000103723","","","Lysosome",1157.6,1115.5,1146.9,942.7,991.9,977.3,1.1744908822418354,0.23203551352418658,9.2950720571556491E-4,3.0317472391461138,0.029264484928335204,1.5336591153136945,248]
["High","Q13418","Integrin-linked protein kinase [OS=Homo sapiens]",24,12,25,12,452,51.4,8.07,41.21,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ILK","ENSG00000166333","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; PPAR signaling pathway; Eukaryotic transcription initiation; Endometrial cancer; Acute viral myocarditis; Genes controlling nephrogenesis; Development of ureteric collection system","Localization of the PINCH-ILK-PARVIN complex to focal adhesions","PPAR signaling pathway; Axon guidance; Focal adhesion; Bacterial invasion of epithelial cells; Shigellosis; Endometrial cancer",1184.9,1212.9,1289.9,1250.4,1184.9,1204,1.013299260846866,0.01906031271708572,0.6847427051830854,0.16447258574885737,0.8291673452341084,0.0813578098872562,6448]
["High","Q13435","Splicing factor 3b subunit 2 [OS=Homo sapiens]",49,43,282,43,895,100.2,5.67,582.83,"RNA metabolism OR transcription;other metabolic processes","nucleus","","SF3B2","ENSG00000087365","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",10027.1,11447.9,11524.2,12136,11089.1,11247.6,0.9572560315844131,-0.06302324949120873,0.4489317691350248,0.3478196601990617,0.6675412785005282,0.17552187382748327,5251]
["High","Q13438-1","Protein os-9 [OS=Homo sapiens]",35,22,48,22,667,75.5,4.87,78.4,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;ER/Golgi","other molecular function","OS9","ENSG00000135506","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",1327,1448.1,1487.4,1343.4,1285,1272,1.0928366321402931,0.12807774902740224,0.08514681425851969,1.069831596389905,0.26194890690721895,0.5817834094899557,2538]
["High","Q13464","Rho-associated protein kinase 1 [OS=Homo sapiens]",27,35,47,31,1354,158.1,5.9,89.19,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function","ROCK1","ENSG00000067900","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; G13 signaling pathway","Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse; EPHB-mediated forward signaling; RND3 GTPase cycle; RHOBTB1 GTPase cycle; Potential therapeutics for SARS; VEGFA-VEGFR2 Pathway; Apoptotic cleavage of cellular proteins; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; RHOH GTPase cycle","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; TGF-beta signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer",2094.3,2271.6,2249.1,2247.5,2174.3,2067.3,1.0194017660384338,0.02772275772092975,0.6122166998388723,0.2130948280399707,0.783380529718439,0.10602722668772356,6102]
["High","Q13492-1","Phosphatidylinositol-binding clathrin assembly protein [OS=Homo sapiens]",18,10,25,9,652,70.7,7.9,40.14,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PICALM","ENSG00000073921","","Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; RND3 GTPase cycle","",838,876,903.1,862,890.6,867.9,0.9987025376836481,-1.8730578234429863E-3,0.9591519075709551,0.01811260513874456,0.9810136356188129,0.008324956093189104,7634]
["High","Q13501-1","sequestosome-1 [OS=Homo sapiens]",58,14,59,14,440,47.7,5.22,141.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","SQSTM1","ENSG00000161011","IL-1 signaling pathway; RANKL/RANK signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Interleukin-1 induced activation of NF-kB; Clear cell renal cell carcinoma pathways; CAMKK2 pathway; 7q11.23 copy number variation syndrome","Interleukin-1 signaling; Signaling by ALK fusions and activated point mutants; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; PINK1-PRKN Mediated Mitophagy; NRIF signals cell death from the nucleus; Pexophagy","Mitophagy; Autophagy; Necroptosis; Cellular senescence; Osteoclast differentiation; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Shigellosis; Fluid shear stress and atherosclerosis",1451.1,1446.6,1453,1414.1,1411,1386.8,1.0329542486763694,0.04677635616866797,0.00635701063469159,2.196747062034383,0.0671658173689742,1.1728516957705735,739]
["High","Q13555-8","Isoform 8 of Calcium/calmodulin-dependent protein kinase type II subunit gamma [OS=Homo sapiens]",22,9,21,7,556,62.1,7.42,36.99,"protein metabolism;other metabolic processes;other biological processes","other cell component","kinase activity;other molecular function","CAMK2G; LOC111145432","ENSCATG00000041481; ENSECAG00000000031; ENSFCAG00000018407; ENSG00000148660; ENSLCNG00005022562; ENSMPUG00000003376; ENSPANG00000022457; ENSPTRG00000002643","Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway; Calcium regulation in cardiac cells","","ErbB signaling pathway; Calcium signaling pathway; cAMP signaling pathway; HIF-1 signaling pathway; Oocyte meiosis; Necroptosis; Adrenergic signaling in cardiomyocytes; Wnt signaling pathway; Axon guidance; Circadian entrainment; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Dopaminergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Melanogenesis; Oxytocin signaling pathway; Glucagon signaling pathway; Aldosterone synthesis and secretion; Cushing syndrome; Gastric acid secretion; Parkinson disease; Pathways of neurodegeneration; Amphetamine addiction; Tuberculosis; Pathways in cancer; Proteoglycans in cancer; Glioma; Diabetic cardiomyopathy; Lipid and atherosclerosis",848.9,852.2,879.8,761.5,799.2,791.3,1.0973214285714283,0.1339861834276949,0.00720046001373463,2.142639757034742,0.07143734661656924,1.1460746847351713,787]
["High","Q13573","SNW domain-containing protein 1 [OS=Homo sapiens]",19,10,17,10,536,61.5,9.52,28.8,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SNW1","ENSG00000100603","TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; mRNA Splicing - Major Pathway; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling","Spliceosome; Notch signaling pathway; Epstein-Barr virus infection; Viral carcinogenesis",604.8,649.3,553.1,1244.7,647.7,493.2,0.7575452716297787,-0.40059598689035797,0.4505320515203832,0.34627430723033503,0.6687745738158084,0.1747202467254387,5260]
["High","Q13574","Diacylglycerol kinase zeta [OS=Homo sapiens]",13,10,17,10,1117,124.1,9.04,42.38,"","","","","","","","",611.1,607.5,603.2,626.5,626,621.7,0.9720414043325152,-0.04091032781249469,3.1275897038299167E-3,2.5047902252573566,0.04854914593937175,1.3138184056546487,503]
["High","Q13615","myotubularin-related protein 3 [OS=Homo sapiens]",4,4,4,4,1198,133.5,5.8,7.86,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;other cell component","other molecular function","MTMR3","ENSG00000100330","","Synthesis of PIPs at the plasma membrane; Macroautophagy","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Autophagy",194.8,188.9,175.5,180,157.3,185.4,1.0698297302467954,0.09738120141554368,0.3041832031861865,0.5168647711014138,0.5404010126229225,0.2672838458525691,4395]
["High","Q13636","ras-related protein rab-31 [OS=Homo sapiens]",17,3,4,3,194,21.6,7.06,11.98,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB31","ENSG00000168461","","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","Endocytosis",301.7,292.3,285.6,280.2,280.9,245.1,1.0910444058546267,0.12570982100388858,0.12648458884560443,0.8979623866386826,0.3270171091743309,0.4854295249371979,3020]
["High","Q13637","Ras-related protein Rab-32 [OS=Homo sapiens]",9,2,2,2,225,25,6.54,5.58,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB32","ENSG00000118508","","RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","",188.6,167.5,158.7,183.5,180.6,177.7,0.9501661129568106,-0.07374833998131262,0.3752395257500068,0.42569142159624834,0.6081092189821613,0.21601841259993754,4818]
["High","Q13794","phorbol-12-myristate-13-acetate-induced protein 1 [OS=Homo sapiens]",41,2,3,2,54,6,10.29,7.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus","","PMAIP1","ENSG00000141682","miRNA regulation of DNA damage response; TP53 network; Apoptosis modulation and signaling; Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; miRNA regulation of p53 pathway in prostate cancer; Chromosomal and microsatellite instability in colorectal cancer ; Unfolded protein response; p53 transcriptional gene network; DNA damage response; DNA damage response (only ATM dependent)","TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation of NOXA and translocation to mitochondria","Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Pathways in cancer; Viral carcinogenesis; Colorectal cancer",93.5,82.4,81,82.4,74.5,78.4,1.0917977050573735,0.12670556967651928,0.18984825060053334,0.72159340041007,0.4125619651235637,0.38451081295608414,3593]
["High","Q13838-1","spliceosome RNA helicase DDX39B [OS=Homo sapiens]",60,24,220,12,428,49,5.67,471.31,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BAT1; DDX39B; LOC101341139","ENSANAG00000030372; ENSCANG00000041217; ENSCCAG00000027897; ENSCJAG00000003152; ENSECAG00000007750; ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439; ENSGGOG00000005989; ENSMFAG00000034233; ENSMICG00000017349; ENSMLEG00000043791; ENSMMUG00000008839; ENSMNEG00000041059; ENSMODG00000015791; ENSOANG00000008361; ENSPANG00000018609; ENSPCOG00000018656; ENSPCTG00005013682; ENSPPAG00000043072; ENSPPYG00000016433; ENSPTRG00000032509; ENSRROG00000039517; ENSSHAG00000003209; ENSSSCG00000001400; ENSSSCG00005031872; ENSSSCG00015055352; ENSSSCG00025077755; ENSSSCG00030066086; ENSSSCG00035021438; ENSSSCG00040071129; ENSSSCG00045038130; ENSSSCG00050005792; ENSSSCG00055028973; ENSSSCG00060042375; ENSSSCG00065025136; ENSSSCG00070024145; ENSVURG00010001931","","Transport of Mature mRNA derived from an Intron-Containing Transcript; RHOBTB2 GTPase cycle; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",8914.3,8865.4,8881.9,8848.6,9755.1,9439.4,0.9507365448185116,-0.07288247845034204,0.15852980505572972,0.7998890744282575,0.37407093317471674,0.4270460369294752,3309]
["High","Q13884","Beta-1-syntrophin [OS=Homo sapiens]",2,1,1,1,538,58,8.63,2.76,"other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SNTB1","ENSG00000172164","IL-18 signaling pathway","","",42.7,43,37,42.1,41.1,45.3,0.9548638132295719,-0.06663311041833554,0.4527674830306504,0.3441247709705163,0.6705630704672455,0.17356036789783436,5272]
["High","Q13952-1","Nuclear transcription factor Y subunit gamma [OS=Homo sapiens]",11,5,13,5,458,50.3,6.1,18.92,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFYC","ENSG00000066136","","PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum  stress; ATF6 (ATF6-alpha) activates chaperone genes","Antigen processing and presentation; Tuberculosis",578.4,543.7,547.4,590.7,533,542.5,1.0019805545552756,2.8545104104759854E-3,0.9606960511639854,0.01741399441462318,0.9816928108216723,8.024389439265334E-3,7641]
["High","Q14011","Cold-inducible RNA-binding protein [OS=Homo sapiens]",46,7,37,2,172,18.6,9.51,75.64,"cell organization and biogenesis;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CIRBP","ENSG00000099622","","","",1849.7,1800.2,1784.3,1402.9,1329.4,1408,1.3125135859720307,0.3923323563505935,1.7822877780913879E-4,3.749022171036214,0.01581375337651995,1.8009650385277471,88]
["High","Q14108-1","Lysosome membrane protein 2 [OS=Homo sapiens]",13,6,21,6,478,54.3,5.14,38.78,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCARB2","ENSG00000138760","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome","Cargo recognition for clathrin-mediated endocytosis","Lysosome",904.2,888.3,951.6,870.5,874.9,869.5,1.0494091552258211,0.0695772814677399,0.08700506257133658,1.0604554763143923,0.26526182294298944,0.5763252501241868,2561]
["High","Q14119","Vascular endothelial zinc finger 1 [OS=Homo sapiens]",11,5,10,3,521,56.9,9.52,26.17,"stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","VEZF1","ENSG00000136451","","","",100,73.8,73.9,75.8,81.5,81.3,1.0381391450125732,0.053999825551134834,0.7507730689017098,0.12449131441663633,0.8687071905726956,0.06112658367508854,6748]
["High","Q14155-1","Isoform 1 of Rho guanine nucleotide exchange factor 7 [OS=Homo sapiens]",24,15,41,12,646,73.1,7.21,77.89,"","","","ARHGEF7","","","","",1851.4,1999.6,2058.4,2139,2017.5,2096.7,0.945020149683362,-0.0815830041374123,0.18248525304380742,0.7387722258950281,0.4034102083142832,0.3942531161419237,3532]
["High","Q14165","Malectin [OS=Homo sapiens]",41,13,56,13,292,32.2,5.41,127.57,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","MLEC","ENSG00000110917","","Neutrophil degranulation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle","",3060.2,3071.3,3159.3,2892.1,3176.5,2971.8,1.0276978894739168,0.039416220353752876,0.40770579536032014,0.38965311519704776,0.6348956621805704,0.19729764016061005,5014]
["High","Q14185","Dedicator of cytokinesis protein 1 [OS=Homo sapiens]",9,13,21,13,1865,215.2,7.56,36.41,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DOCK1","ENSG00000150760","Integrin-mediated cell adhesion; Focal adhesion; Hepatocyte growth factor receptor signaling; Regulation of actin cytoskeleton","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; DCC mediated attractive signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases","Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection",667.4,669.4,697.6,627.6,666.2,651.1,1.0460177901177437,0.06490738838828636,0.11533388480252522,0.9380430793420211,0.30755702614006725,0.5120743470697401,2928]
["High","Q14197","Peptidyl-tRNA hydrolase ICT1, mitochondrial [OS=Homo sapiens]",17,3,3,3,206,23.6,10.07,2.99,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL58","ENSG00000167862","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",27.6,25.1,23.4,32.2,24.7,23.3,0.9488778054862841,-0.07570578295137517,0.674368603939105,0.171102657027139,0.8236305427117991,0.08426755680236804,6393]
["High","Q14247-1","Src substrate cortactin [OS=Homo sapiens]",52,29,112,29,550,61.5,5.4,244.18,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CTTN","ENSG00000085733; ENSG00000288401","Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma","Clathrin-mediated endocytosis; RHO GTPases activate PAKs","Tight junction; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Proteoglycans in cancer",6369.8,6023.3,5875.1,6743.4,5974.3,6198.9,0.9657232272184221,-0.050318317764982565,0.47031017816949283,0.3276156224127228,0.6840875318828987,0.164888324915023,5368]
["High","Q14315","Filamin-C [OS=Homo sapiens]",65,139,716,120,2725,290.8,5.97,1666.9,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","FLNC","ENSG00000128591","Focal adhesion; MAPK signaling pathway; Ebola virus infection in host","Cell-extracellular matrix interactions","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer",18536.3,19035.3,19006.6,16614.4,16484.9,16742.9,1.1351465224247723,0.18287852970323504,2.2779013512999426E-4,3.6424650877695424,0.01662229322518687,1.7793090607961164,107]
["High","Q14332","Frizzled-2 [OS=Homo sapiens]",2,2,2,1,565,63.5,8.1,3.91,"cell-cell signaling;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","FZD2","ENSG00000180340","MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease","WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Asymmetric localization of PCP proteins; Ca2+ pathway; Class B/2 (Secretin family receptors); Disassembly of the destruction complex and recruitment of AXIN to the membrane","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer",76,60.1,71.2,81.8,63.2,80.2,0.9205150976909415,-0.11948671097081465,0.47567937268125304,0.32268568087974003,0.6883069944209088,0.16221781722097126,5396]
["High","Q14457","Beclin-1 [OS=Homo sapiens]",18,9,12,9,450,51.9,4.89,21.14,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BECN1","ENSG00000126581","Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; Malignant pleural mesothelioma; Alzheimer's disease","Ub-specific processing proteases; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Autophagy; Mitophagy; Autophagy; Apoptosis; Apelin signaling pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Kaposi sarcoma-associated herpesvirus infection",496.2,526.4,497.3,485.1,478.1,462.6,1.0659980361902088,0.09220478032855536,0.058036566903201935,1.2362982857431397,0.2113570496176309,0.6749832621052368,2144]
["High","Q14527","Helicase-like transcription factor [OS=Homo sapiens]",31,25,42,25,1009,113.9,8.6,87.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HLTF","ENSG00000071794","Retinoblastoma gene in cancer","E3 ubiquitin ligases ubiquitinate target proteins","",1949.4,2016.8,1994.6,2397.4,2379.6,2500.9,0.8190274667142994,-0.28801626032503924,5.0469177312024809E-4,3.296973774556189,0.022138389688330883,1.6548539722064475,178]
["High","Q14596-1","Next to BRCA1 gene 1 protein [OS=Homo sapiens]",7,4,6,4,966,107.3,5.12,13.95,"other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NBR1","ENSG00000188554","","Pexophagy","Mitophagy",194.1,184.7,195.5,197,178.4,181,1.032171099928109,0.04568214184379037,0.42550023332199577,0.3711001974350279,0.6471183914643831,0.18901625711181708,5134]
["High","Q14657","EKC/KEOPS complex subunit LAGE3 [OS=Homo sapiens]",21,2,5,2,143,14.8,8.63,9.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","LAGE3","ENSG00000196976","","tRNA modification in the nucleus and cytosol","",181.1,119,110.1,138.8,92.7,104.1,1.2222884386174018,0.28958477604002886,0.39769062751407264,0.4004546440325863,0.6260420200866692,0.2033965158641483,4960]
["High","Q14671-3","Isoform 3 of Pumilio homolog 1 [OS=Homo sapiens]",21,22,57,1,1188,126.6,6.84,117.66,"","","","PUM1","","","","",12.6,14,13.4,11.2,18.2,9.1,1.0389610389610389,0.055141554192460855,0.8660420069774514,0.06246104221353385,0.9342437124177867,0.029539816327078992,7238]
["High","Q14681","BTB/POZ domain-containing protein KCTD2 [OS=Homo sapiens]",24,3,6,2,263,28.5,5.29,11.77,"cell organization and biogenesis;protein metabolism;other metabolic processes","other cell component","other molecular function","KCTD2","ENSG00000180901","","","",23.1,20.8,25.1,24.8,15.2,19.8,1.1538461538461537,0.20645087746742624,0.36983017569244975,0.4319976561783119,0.6041075338507631,0.21888574813179537,4780]
["High","Q14691","DNA replication complex GINS protein PSF1 [OS=Homo sapiens]",40,6,16,6,196,23,7.39,36.45,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;developmental processes","nucleus;other cell component","","GINS1","ENSG00000101003","","Unwinding of DNA","",655.4,618.1,589.7,612.4,603.1,569.7,1.0436925834640376,0.061696832959010954,0.3218759030600619,0.4923115351496416,0.5597343098202591,0.2520180714943294,4490]
["High","Q14697-2","Isoform 2 of Neutral alpha-glucosidase AB [OS=Homo sapiens]",61,47,354,1,966,109.4,6.24,762.7,"","","","GANAB","","","","",689.2,699.2,754.8,766.9,703,740.2,0.9697298764761773,-0.04434516216548418,0.46385480843015336,0.3336179370424523,0.6793806685842501,0.16788681490878093,5331]
["High","Q14739","Lamin-B receptor [OS=Homo sapiens]",24,17,59,17,615,70.7,9.36,103.64,"other metabolic processes;developmental processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","LBR","ENSG00000143815","Gastric cancer network 2; ATM signaling in development and disease ; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias","RHOC GTPase cycle; RHOA GTPase cycle; RHOD GTPase cycle; Regulation of MECP2 expression and activity; CDC42 GTPase cycle; RAC1 GTPase cycle; Cholesterol biosynthesis; Initiation of Nuclear Envelope (NE) Reformation; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","Steroid biosynthesis; Metabolic pathways",3631.4,3594.9,3581,3558.2,3516.3,3486.3,1.023341034770093,0.033287012316785915,0.0329989968715609,1.4814992619332437,0.15373279688135294,0.813233471568866,1676]
["High","Q14790-4","Isoform 4 of Caspase-8 [OS=Homo sapiens]",20,6,8,6,496,57.7,5.43,17.84,"","","","CASP8","","","","",289.9,296.7,279.4,324.8,318.5,326.5,0.8929676221901423,-0.16332022878224275,0.003461880383425255,2.4606879421555488,0.05129100955177304,1.2899587527094598,527]
["High","Q14894","Ketimine reductase mu-crystallin [OS=Homo sapiens]",26,6,9,6,314,33.8,5.14,14.17,"other metabolic processes;transport;other biological processes","cytosol;other cytoplasmic organelle;other cell component","other molecular function","CRYM","ENSG00000103316","","Lysine catabolism","",360.6,348.8,353.4,304.7,341.1,345.9,1.0716950690733087,0.09989447210568442,0.15291426334676084,0.8155520031169041,0.3663561117556025,0.43609655892341287,3259]
["High","Q14974","Importin subunit beta-1 [OS=Homo sapiens]",54,37,300,37,876,97.1,4.78,636.72,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","KPNB1","ENSG00000108424","Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome","Neutrophil degranulation; Assembly of the ORC complex at the origin of replication; Apoptosis induced DNA fragmentation; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Regulation of cholesterol biosynthesis by SREBP (SREBF); Initiation of Nuclear Envelope (NE) Reformation; Postmitotic nuclear pore complex (NPC) reformation; Inhibition of nitric oxide production","Nucleocytoplasmic transport; Chemical carcinogenesis",10599.7,10442.9,10611.4,10389.1,10714.7,10753.1,0.9936308931503065,-0.00921806555010318,0.624157311993196,0.20470593736847334,0.7930708367848452,0.10068801993231087,6145]
["High","Q14BN4","Sarcolemmal membrane-associated protein [OS=Homo sapiens]",22,18,27,18,828,95.1,5.47,58.18,"other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","SLMAP","ENSG00000163681","","","",966.6,998.1,1040.1,1016.9,995.4,1015,0.9925676345258151,-0.010762682636352196,0.7542802341677065,0.12246727277506514,0.8709583064746307,0.0600026345461799,6762]
["High","Q15006","ER membrane protein complex subunit 2 [OS=Homo sapiens]",34,9,37,9,297,34.8,6.57,77.06,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC2","ENSG00000104412","","","",893.7,855.4,870.4,829.8,855.8,843.3,1.035825853137728,0.050781472200944824,0.08786307600851621,1.0561935965391667,0.2670435568215238,0.5734178961468773,2569]
["High","Q15007","Pre-mRNA-splicing regulator WTAP [OS=Homo sapiens]",32,10,23,10,396,44.2,5.19,66.49,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","WTAP","ENSG00000146457","","Processing of Capped Intron-Containing Pre-mRNA","",784.2,831.4,781.1,826.8,816.9,835.4,0.96676213141866,-0.04876713180092185,0.18410153408820154,0.7349425925754811,0.4052621308600727,0.39226397638878846,3547]
["High","Q15022","Polycomb protein suz12 [OS=Homo sapiens]",13,7,11,7,739,83,8.81,21.89,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","SUZ12","ENSG00000178691","Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma","HCMV Early Events; Defective pyroptosis; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines","",353.6,371.3,376,382.3,412.4,392.3,0.9274641954507161,-0.1086365070005479,0.06206879022047256,1.2071267193430277,0.2175193510060367,0.6625021011860837,2228]
["Medium","Q15035","Translocating chain-associated membrane protein 2 [OS=Homo sapiens]",2,1,1,1,370,43.3,9.22,1.96,"cell organization and biogenesis;other metabolic processes;transport","other membranes;ER/Golgi","","TRAM2","ENSG00000065308","","","",55,52,61.8,54.5,56,60.8,0.9854057209573848,-0.02121024737681374,0.8218253925366683,0.08522044415447454,0.9097990450767484,0.04105452334044093,7053]
["High","Q15047","Histone-lysine N-methyltransferase SETDB1 [OS=Homo sapiens]",16,19,52,19,1291,143.1,6.02,98.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETDB1","ENSG00000143379","Histone modifications; Malignant pleural mesothelioma","PKMTs methylate histone lysines","Lysine degradation; Metabolic pathways; Signaling pathways regulating pluripotency of stem cells",1968.7,2073.2,1988.3,2292.7,2356.4,2292.2,0.8687421664529698,-0.20300003105065323,1.3977095878576636E-3,2.8545830556953957,0.0339978705981079,1.4685482834416324,321]
["High","Q15054","DNA polymerase delta subunit 3 [OS=Homo sapiens]",23,11,24,11,466,51.4,9.35,42.02,"DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","POLD3","ENSG00000077514","Homologous recombination; Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair","HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Dual Incision in GG-NER; Termination of translesion DNA synthesis; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)","DNA replication; Base excision repair; Nucleotide excision repair; Mismatch repair; Homologous recombination",1001.1,992.9,974.9,1108.4,1118.9,1090.8,0.8947590488532592,-0.1604288659470606,4.9632117394041153E-4,3.30423719663559,0.021894213141958944,1.6596706583387613,177]
["High","Q15070-1","Mitochondrial inner membrane protein OXA1L [OS=Homo sapiens]",11,5,7,5,435,48.5,9.45,14.77,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;other cell component","translation activity;other molecular function","OXA1L","ENSG00000155463","","Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination","Protein export",517,553.5,545.7,611.4,585.6,572.7,0.9132621348251116,-0.13089907659221184,0.032296898919093306,1.4908391757178525,0.15246323262411157,0.8168348762757449,1654]
["Medium","Q15121","Astrocytic phosphoprotein PEA-15 [OS=Homo sapiens]",8,1,1,1,130,15,5.02,2.31,"transport;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus","","PEA15","ENSG00000162734","Apoptosis modulation and signaling","RAF/MAP kinase cascade; RAF-independent MAPK1/3 activation","",104.7,115.7,104.8,104.5,87.7,95.5,1.1303441084462982,0.1767620363357407,0.10866989993521206,0.963890732843766,0.29688403733174795,0.527413152640082,2858]
["High","Q15149-3","Isoform 3 of Plectin [OS=Homo sapiens]",41,185,463,1,4570,517.7,5.74,980.82,"","","","PLEC","","","","",11.2,16.8,12.4,14,14.6,13.8,0.9528301886792452,-0.0697089718114046,0.7179281902722876,0.14391899326206756,0.8503615457594087,0.07039638729249148,6592]
["High","Q15172-1","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [OS=Homo sapiens]",5,2,2,2,486,56.2,6.71,3.11,"protein metabolism;other metabolic processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP2R5A","ENSG00000066027; ENSGGOG00000014986; ENSNLEG00000002787; ENSPPAG00000015631; ENSPPYG00000000237; ENSPTRG00000001958","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; Glycogen metabolism","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Separation of Sister Chromatids; RAF activation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; Dopaminergic synapse; Human papillomavirus infection",66.9,70.1,72.1,64.7,81.3,66.5,0.9840000000000001,-0.023269779322847028,0.8460575240418682,0.07260010797202097,0.9243063030248926,0.03418408541455261,7147]
["High","Q15233","Non-POU domain-containing octamer-binding protein [OS=Homo sapiens]",58,27,490,25,471,54.2,8.95,715.13,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","NONO","ENSG00000147140","mRNA processing","","",12274.7,12520.9,12562.5,13086.9,13434.7,13453.3,0.9345389231742919,-0.0976733419911839,0.004269909542278008,2.3695813253744213,0.056316644773828854,1.2493632274387059,592]
["High","Q15283-1","ras GTPase-activating protein 2 [OS=Homo sapiens]",8,6,6,6,850,96.6,7.2,14.19,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;other molecular function","RASA2","ENSG00000155903","MAPK signaling pathway; Ebola virus infection in host; Ras signaling; Modulators of TCR signaling and T cell activation","Regulation of RAS by GAPs","MAPK signaling pathway; Ras signaling pathway; Viral carcinogenesis",353.9,372.4,369.3,358,383.1,339.9,1.0135060129509714,0.019354648083365747,0.7416045259106683,0.12982762841583687,0.8641170181033424,0.06342744169311626,6701]
["High","Q15365","Poly(RC)-binding protein 1 [OS=Homo sapiens]",84,18,347,12,356,37.5,7.09,948.55,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCBP1","ENSG00000169564","Ferroptosis","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Spliceosome; Ferroptosis",9876.4,9767.4,9813.3,10058.1,9812.8,10007,0.9859160115001387,-0.020463343774255367,0.1588695943279076,0.798959213422991,0.3745331499131348,0.4265097368771981,3312]
["High","Q15366-1","Poly(rC)-binding protein 2 [OS=Homo sapiens]",65,16,384,1,365,38.6,6.79,990.65,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101348589; Pcbp2; PCBP2","ENSBIXG00000004442; ENSCAFG00000006821; ENSG00000197111; ENSRNOG00000036852","mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation","mRNA Splicing - Major Pathway; Negative regulators of DDX58/IFIH1 signaling; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway","Ferroptosis",349.2,326.8,348.9,319.2,315.2,316.4,1.077934371055953,0.10826934373570361,0.030260922273089616,1.5191178399608858,0.14721325925749765,0.8320530720431413,1605]
["High","Q15390","Mitochondrial fission regulator 1 [OS=Homo sapiens]",9,3,6,3,333,37,9.01,10.91,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;mitochondrion","","MTFR1","ENSG00000066855","","","",302.2,308.6,307.1,299.5,283.8,282.1,1.0606655881673215,0.08496986799640793,0.04060451495822214,1.3914256730133834,0.17193061431333975,0.7646467850723584,1844]
["High","Q15427","Splicing factor 3b subunit 4 [OS=Homo sapiens]",27,8,35,8,424,44.4,8.56,70.93,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","SF3B4","ENSG00000143368","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",1062.4,1043.6,1040.2,1097.1,1064.2,1072.6,0.9728810414669594,-0.039664683897100456,0.07219872349627186,1.1414704808711649,0.23796016591764063,0.6234957369352947,2369]
["High","Q15438-1","Cytohesin-1 [OS=Homo sapiens]",14,3,3,2,398,46.4,5.54,9.12,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CYTH1","ENSCATG00000038229; ENSG00000108669; ENSMFAG00000037544; ENSMMUG00000013313; ENSPANG00000019854; ENSPTRG00000009717","","Intra-Golgi traffic","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection",21.7,23.5,17.5,19.7,23.9,17,1.034653465346535,0.04914764932908836,0.8069390462345897,0.09315926934700924,0.901757560183151,0.044910207942716975,6987]
["High","Q15542","Transcription initiation factor TFIID subunit 5 [OS=Homo sapiens]",24,11,28,11,800,86.8,5.64,63.38,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","TAF5","ENSG00000148835","Eukaryotic transcription initiation","Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","Basal transcription factors",590.8,623.3,679.5,631.1,647,632,0.991361708811057,-0.012516558870378116,0.8452421404563298,0.07301885886129528,0.9241913783339901,0.03423808727742862,7141]
["High","Q15560","transcription elongation factor A protein 2 [OS=Homo sapiens]",25,6,17,4,299,33.6,9.13,31.02,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","TCEA2","ENSG00000171703","","","",137.5,139.7,140.2,127.4,124,131.7,1.0895327590707387,0.12370957473595497,0.008588023964658862,2.0661067523465735,0.07770022145545352,1.1095777434031475,863]
["Medium","Q15573-1","TATA box-binding protein-associated factor RNA polymerase I subunit A [OS=Homo sapiens]",2,1,1,1,450,52.6,9.1,2.59,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus","nucleic acid binding activity","TAF1A","ENSG00000143498","","RNA Polymerase I Transcription Initiation; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; SIRT1 negatively regulates rRNA expression; RNA Polymerase I Transcription Termination","",25.4,32.1,18.3,30,18.3,29,0.9805950840879689,-0.028270565753755746,0.931534412983003,0.030801096653339414,0.9677249463240137,0.014248063423192021,7516]
["High","Q15637-5","Isoform 5 of Splicing factor 1 [OS=Homo sapiens]",25,13,62,13,673,71.7,9.58,126.09,"","","","SF1","","","","",2898.5,2895.8,2933.4,3328.5,2928.4,3061.9,0.9365690861484313,-0.09454267589416086,0.17094159777563864,0.7671522410467038,0.3884493583912068,0.41066559154727306,3436]
["High","Q15678","Tyrosine-protein phosphatase non-receptor type 14 [OS=Homo sapiens]",9,7,12,7,1187,135.2,8.31,17.6,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN14","ENSG00000152104","VEGFA-VEGFR2 signaling pathway","Interleukin-37 signaling","",205.9,231.3,226,218.8,241.1,215,0.9826640983849461,-0.02522974689754659,0.745889655209566,0.12732541606372455,0.8661371843956411,0.062413316172522534,6724]
["High","Q15723-1","Isoform 1 of ETS-related transcription factor Elf-2 [OS=Homo sapiens]",3,1,1,1,581,62.7,6.7,2.61,"","","","ELF2","","","","",32.1,38.8,30.5,38.2,33.8,27.8,1.0160320641282568,0.022945931666080308,0.8989409236969639,0.0462688481504692,0.9523650925679639,0.021196531350885294,7370]
["High","Q15751","Probable E3 ubiquitin-protein ligase HERC1 [OS=Homo sapiens]",3,10,12,10,4861,531.9,6.04,18.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","HERC1","ENSG00000103657","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",283.1,283.9,283.2,277.6,274.2,275.8,1.0273078782020302,0.038868613779165485,0.00175107433275015,2.7566954178126037,0.0371532293209597,1.4300034318274861,368]
["High","Q15800","Methylsterol monooxygenase 1 [OS=Homo sapiens]",9,2,7,2,293,35.2,7.23,14.11,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","MSMO1","ENSG00000052802","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways","Cholesterol biosynthesis","Steroid biosynthesis; Metabolic pathways",383.6,356.2,410.9,369.6,429,424.7,0.9406523338510585,-0.08826649511007677,0.38441933209489176,0.4151947801839748,0.6150709313518268,0.21107479752805008,4880]
["High","Q15811-7","Isoform 7 of Intersectin-1 [OS=Homo sapiens]",33,30,62,29,1215,137,7.33,118.38,"","","","ITSN1","","","","",2100.8,2251.4,2230.8,2437.7,2291,2309.8,0.9352845066420403,-0.09652280594446871,0.0826648353402695,1.0826791949872998,0.25776638751470615,0.5887737148670565,2504]
["High","Q15942","Zyxin [OS=Homo sapiens]",35,12,44,12,572,61.2,6.67,85.33,"cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","ZYX","ENSG00000159840; ENSG00000285443","Integrin-mediated cell adhesion; Focal adhesion","","Focal adhesion",858.4,776,749.6,1042.3,771.7,700.1,0.9482518595123504,-0.07665779925462428,0.7116329860139777,0.14774392945850293,0.8466296441866735,0.07230652905679066,6563]
["High","Q16143","Beta-synuclein [OS=Homo sapiens]",30,4,13,1,134,14.3,4.41,31.63,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","cytosol;other cell component","enzyme regulator activity;other molecular function","SNCB","ENSG00000074317","","MTF1 activates gene expression","",209.3,194.5,197.5,208.8,187.4,185.1,1.034405642525374,0.048802049964181506,0.4906350705435754,0.3092414116959069,0.7003434425601895,0.1546889333707023,5470]
["High","Q16513","Serine/threonine-protein kinase N2 [OS=Homo sapiens]",18,14,30,10,984,112,6.3,68.68,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","PKN2","ENSG00000065243","PI3K-Akt signaling pathway","RAC1 GTPase cycle; RHO GTPases activate PKNs; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle","PI3K-Akt signaling pathway; NOD-like receptor signaling pathway; Yersinia infection",460.6,454.6,464.2,449.1,465.6,483.5,0.986554141038478,-0.01952986820166859,0.5764866506949049,0.23921074491163122,0.7589289780181786,0.11979886428633058,5931]
["High","Q16539-2","Isoform CSBP1 of Mitogen-activated protein kinase 14 [OS=Homo sapiens]",28,8,23,1,360,41.5,5.88,39.57,"","","","MAPK14","","","","",19.9,25.1,23.5,17.4,19.8,21.7,1.1629881154499149,0.21783635401742807,0.1810044245747347,0.7423108088606172,0.4020718483867791,0.39569633355782446,3515]
["High","Q16566","calcium/calmodulin-dependent protein kinase type IV [OS=Homo sapiens]",7,3,5,3,473,51.9,5.82,11.99,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","CAMK4","ENSG00000152495","Energy metabolism; Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway; Common pathways underlying drug addiction; Mitochondrial gene expression; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; CAMKK2 pathway; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells","Transcriptional activation of mitochondrial biogenesis; Regulation of MECP2 expression and activity; Negative regulation of NMDA receptor-mediated neuronal transmission; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; Loss of phosphorylation of MECP2 at T308","Calcium signaling pathway; cAMP signaling pathway; Longevity regulating pathway; Apelin signaling pathway; Osteoclast differentiation; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Oxytocin signaling pathway; Aldosterone synthesis and secretion; Amphetamine addiction; Alcoholism; Glioma",205.1,204.8,185.4,204.2,204.8,203.2,0.9723946422737665,-0.04038615049887953,0.4372177224432956,0.3593022424146164,0.6573841665390433,0.1821807603510373,5193]
["High","Q16629","serine/arginine-rich splicing factor 7 [OS=Homo sapiens]",35,12,87,11,238,27.4,11.82,155.06,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","other molecular function","SRSF7","ENSG00000115875","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection",3760.9,3602.5,3523,3881,3677.7,3889.8,0.9509018648731274,-0.0726316353643598,0.12971418959960693,0.8870125132934258,0.3327228621529996,0.4779173567333256,3044]
["High","Q16658","Fascin [OS=Homo sapiens]",68,33,275,33,493,54.5,7.24,687.19,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","FSCN1","ENSG00000075618","VEGFA-VEGFR2 signaling pathway","Interleukin-4 and Interleukin-13 signaling","MicroRNAs in cancer",8417.2,8479.9,8465,7902.8,8825.2,8387.5,1.0098186378929346,0.014096210098773017,0.7735984621809311,0.1114844022484772,0.8815319312184341,0.05476195188331464,6852]
["High","Q16698","2,4-dienoyl-CoA reductase, mitochondrial [OS=Homo sapiens]",26,6,11,6,335,36,9.28,28.23,"other metabolic processes;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","DECR1","ENSG00000104325","Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway","mitochondrial fatty acid beta-oxidation of unsaturated fatty acids","",243.6,226.8,250.1,242.8,245.2,245.4,0.9824106899372784,-0.025601835649556034,0.5718159670757472,0.24274372180756498,0.7559666561001412,0.12149735977798923,5906]
["High","Q16774-1","guanylate kinase [OS=Homo sapiens]",21,4,11,4,197,21.7,6.55,26.05,"other metabolic processes;transport","cytosol;other cell component","kinase activity;other molecular function","GUK1","ENSG00000143774","","Interconversion of nucleotide di- and triphosphates; Abacavir metabolism","Purine metabolism; Metabolic pathways",799.3,731.6,720.4,663.7,643.8,613.6,1.1718806933527668,0.22882569956412632,0.01838500017423559,1.7355363616792876,0.113031560126324,0.9468002779766092,1270]
["High","Q16799-1","Reticulon-1 [OS=Homo sapiens]",4,2,2,1,776,83.6,4.69,6.67,"developmental processes;other biological processes","other membranes;ER/Golgi","","RTN1","ENSG00000139970","","","",28.7,21.3,16.5,19.2,11,18.6,1.362704918032787,0.44647319282566583,0.2530327865857757,0.5968232017066505,0.4877018014469851,0.3118456402316033,4051]
["Medium","Q16854","Deoxyguanosine kinase, mitochondrial [OS=Homo sapiens]",3,1,1,1,277,32,8.66,2.25,"protein metabolism;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","DGUOK","ENSG00000114956","","Purine salvage","Purine metabolism; Metabolic pathways",86,83.3,95.1,80.7,111.7,94.4,0.921896792189679,-0.11732284719421338,0.48240259822941134,0.31659036174340827,0.6936647305663433,0.1588503866736198,5430]
["High","Q1KMD3","heterogeneous nuclear ribonucleoprotein U-like protein 2 [OS=Homo sapiens]",55,37,154,37,747,85.1,4.91,356.2,"","nucleus","","HNRNPUL2","ENSG00000214753","","","",5758.3,6048.9,5913,5752.4,5765.3,6086.7,1.0065779009793006,0.009458829494691729,0.7933571977218987,0.10053123377694725,0.8928413087074928,0.04922572462435289,6938]
["High","Q2M1P5","Kinesin-like protein KIF7 [OS=Homo sapiens]",16,16,22,15,1343,150.5,6.79,36.2,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF7","ENSG00000166813","Hedgehog signaling pathway; Hedgehog signaling pathway; Ciliopathies","Hedgehog 'on' state; Hedgehog 'off' state","Hedgehog signaling pathway; Pathways in cancer; Basal cell carcinoma",662.8,692.4,699.8,743.2,633,700.9,0.9893601656155216,-0.015432281125469634,0.8392049939823375,0.07613194038585389,0.9212023890080263,0.035644944425069075,7113]
["High","Q2NKX8","Dna excision repair protein ercc-6-like [OS=Homo sapiens]",28,28,42,28,1250,141,5.31,93.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","ERCC6L","ENSG00000186871","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",1914.8,1781.7,1892.2,1774.6,1726.6,1788.9,1.0564450577493807,0.07921773937543529,0.09259905345834611,1.0333934526260373,0.2737650168128612,0.562622049174326,2641]
["Low","Q2TAK8-1","PWWP domain-containing protein MUM1 [OS=Homo sapiens]",2,1,1,1,710,78.6,8.54,0,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","other molecular function","PWWP3A","ENSG00000160953","IL-18 signaling pathway","","",29.4,34.3,35,55.8,49.9,66.3,0.5738372093023255,-0.8012865751330629,0.008761568731446815,2.0574181278027237,0.0782726872484402,1.1063897557784914,874]
["High","Q2TAZ0-1","Autophagy-related protein 2 homolog A [OS=Homo sapiens]",9,11,13,11,1938,212.7,5.88,25.74,"cell organization and biogenesis;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ATG2A","ENSG00000110046","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease","","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",264.6,270.4,299.3,260.8,234.5,235.3,1.1419381330413358,0.19148449170582482,0.06610152850768715,1.1797884979307134,0.22498724262773376,0.6478421068373269,2294]
["High","Q32P28-1","Prolyl 3-hydroxylase 1 [OS=Homo sapiens]",42,25,107,23,736,83.3,5.14,239.1,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","P3H1","ENSG00000117385","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",4260.7,4257.4,4250.3,4172.7,4011.6,4092.9,{"$f":"AVERAGE(T3522:V3522)/AVERAGE(W3522:Y3522)","v":1.0400091226012445},{"$f":"LOG(Z3522,2)","v":0.05659618324507204},{"$f":"TTEST(T3522:V3522,W3522:Y3522,2,2)","v":0.024604272391718283},{"$f":"-LOG10(AB3522)","v":1.6089894735859696},{"$f":"AB3522*7808/AF3522","v":0.13212528117918593},{"$f":"-LOG10(AD3522)","v":0.8790140754503531},1454]
["Low","Q3C1V8","Brain-specific homeobox protein homolog [OS=Homo sapiens]",6,1,1,1,233,25.9,7.5,0,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BSX","ENSG00000188909","","","",144,175.3,144.7,150.3,165.4,158.8,0.9778714436248681,-0.032283281893537526,0.7703933856119987,0.11328745460177445,0.8798056976537203,0.05561322984317704,6837]
["High","Q3KR37","GRAM domain-containing protein 1B [OS=Homo sapiens]",3,2,2,2,738,85.3,6.21,2.16,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","GRAMD1B","ENSG00000023171","Ectoderm differentiation","","",36.8,40.8,32.9,32.9,32.7,36.3,1.0843964671246322,0.1168923181129804,0.3258840116936774,0.48693694608146537,0.5629430007310251,0.24953557623421208,4520]
["High","Q3T8J9-1","GON-4-like protein [OS=Homo sapiens]",7,9,10,8,2241,248.5,5.01,14.2,"developmental processes;other biological processes","nucleus","other molecular function","GON4L","ENSG00000116580","","","",243.5,242.9,260.3,248.1,226.2,252,1.0280875671210243,0.03996315098209922,0.5278735961019121,0.27747006058669677,0.7242377505471322,0.14011884153638637,5691]
["High","Q3YEC7-1","Rab-like protein 6 [OS=Homo sapiens]",24,15,40,15,729,79.5,5.22,51.27,"","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RABL6","ENSG00000196642","","","",1152.1,1228.6,1210.3,1255.3,1166.6,1204.4,0.9902655599371261,-0.014112629666062245,0.7504249227785372,0.12469275079443386,0.8684330512901761,0.061263656291093115,6747]
["High","Q49A26-5","Isoform 5 of Putative oxidoreductase GLYR1 [OS=Homo sapiens]",39,11,34,2,472,51.5,8.27,60.96,"","","","","","","","",39.4,33.7,41.6,40.3,30.9,31.8,1.1135922330097088,0.15522105394524432,0.3637722089033389,0.43917048279026927,0.5988474398307547,0.22268380278350539,4743]
["High","Q4G0N4","NAD kinase 2, mitochondrial [OS=Homo sapiens]",6,2,4,2,442,49.4,8.18,10.44,"other metabolic processes","mitochondrion","kinase activity;other molecular function","NADK2","ENSG00000152620","","Nicotinate metabolism","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors",137,157.2,160.3,154.9,192.2,188.5,0.8485810306198656,-0.23687566624284112,0.12435001366751948,0.9053541626600045,0.32299564428343047,0.49080333425225847,3006]
["High","Q4G148-1","Glucoside xylosyltransferase 1 [OS=Homo sapiens]",13,5,12,5,440,50.5,8.65,15.35,"protein metabolism;other metabolic processes","other membranes","other molecular function","GXYLT1","ENSG00000151233","","","Other types of O-glycan biosynthesis",502.4,514.7,478.4,491,478,484.5,1.0288957688338494,0.04109683898311489,0.2831057436106898,0.5480513196383396,0.5190161178944038,0.28481915505345307,4259]
["High","Q4V328","GRIP1-associated protein 1 [OS=Homo sapiens]",57,35,105,35,841,95.9,5.11,236.5,"","","","","","","","",3285.9,3666.1,3640.2,3603.2,3139.5,3251.5,1.0598347041283944,0.08383927410003666,0.3439686913059638,0.46348108595131327,0.5805679943184101,0.2361469097272785,4626]
["High","Q4ZIN3-1","Membralin [OS=Homo sapiens]",4,3,5,3,620,67.8,5.3,7.84,"stress response;other biological processes","other membranes;ER/Golgi","","TMEM259","ENSG00000182087","","","",270.7,277.1,322.2,268,235.4,243.5,1.1648145668764225,0.2201003027414239,0.09616583229201058,1.0169792053306608,0.27892378103121046,0.5545144562239647,2692]
["High","Q53EP0","Fibronectin type III domain-containing protein 3B [OS=Homo sapiens]",6,5,8,5,1204,132.8,5.95,11.71,"","other membranes","","FNDC3B","ENSG00000075420","","","",120.9,111.4,120,131.4,125.6,112,{"$f":"AVERAGE(T3586:V3586)/AVERAGE(W3586:Y3586)","v":0.9547425474254743},{"$f":"LOG(Z3586,2)","v":-0.06681634145279468},{"$f":"TTEST(T3586:V3586,W3586:Y3586,2,2)","v":0.4399001205818353},{"$f":"-LOG10(AB3586)","v":0.3566459189778574},{"$f":"AB3586*7808/AF3586","v":0.6592591442424126},{"$f":"-LOG10(AD3586)","v":0.18094383761874652},5210]
["High","Q53G59-1","Kelch-like protein 12 [OS=Homo sapiens]",20,8,12,7,568,63.2,5.44,18.03,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","KLHL12","ENSCANG00000030198; ENSCATG00000031800; ENSG00000117153; ENSGGOG00000009159; ENSMLEG00000023751; ENSMMUG00000017849; ENSMNEG00000042480; ENSPPAG00000041960; ENSPTRG00000001861; ENSRBIG00000033303; ENSRROG00000044766","","Degradation of DVL","",391.6,373.1,386.4,354.1,358.2,353,1.0805406927626022,0.11175340458182177,0.007542437648763263,2.1224882713299684,0.07324795169346214,1.1352045154197843,804]
["Medium","Q53HI1","protein unc-50 homolog [OS=Homo sapiens]",2,1,2,1,259,30.4,9.47,4.67,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity","UNC50","ENSG00000115446","","","",192.9,177.2,198.6,227.7,240.7,231.9,0.8120805369127518,-0.3003052831875668,0.004174365973720225,2.379409478270151,0.05590643142848631,1.2525382283705297,583]
["High","Q53HV7-1","single-strand selective monofunctional uracil DNA glycosylase [OS=Homo sapiens]",8,2,3,2,270,29.8,6.62,7.09,"DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","nucleic acid binding activity;other molecular function","SMUG1","ENSG00000123415; ENSPPAG00000033677","Fluoropyrimidine activity; Base excision repair; DNA repair pathways, full network","Displacement of DNA glycosylase by APEX1; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine","Base excision repair",118.7,124.8,122.7,114.9,121.9,127.4,1.0054914881933001,0.007900868820498503,0.8767960111868724,0.05710143459359185,0.9409047904545217,0.026454320326402426,7276]
["High","Q587I9","vesicle transport protein SFT2C [OS=Homo sapiens]",27,4,12,4,215,21.8,9.89,39.1,"transport","other membranes","","SFT2D3","ENSG00000173349","","","",387.3,354.4,351,328.7,363.7,335,1.0635584971773409,0.08889938568855377,0.24065530921776226,0.6186045526920335,0.47223841527325655,0.3258386871797864,3979]
["High","Q587J7-1","Putative ATP-dependent RNA helicase TDRD12 [OS=Homo sapiens]",15,15,33,15,1177,132.5,6.74,54.58,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","other cell component","nucleic acid binding activity;other molecular function","TDRD12","ENSG00000173809","","PIWI-interacting RNA (piRNA) biogenesis","",1050.4,1075.5,1037.5,1250.8,1449.6,1321.7,0.7865045622933294,-0.34647296055107774,0.008445386333566975,2.073380478869923,0.07721496076404091,1.1122985449002927,854]
["High","Q5BJF2","sigma intracellular receptor 2 [OS=Homo sapiens]",10,2,10,2,176,20.8,9.38,9.4,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","","TMEM97","ENSG00000109084","","","",382.8,370.3,373.5,359.7,398.9,376.4,0.9925991189427312,-0.010716920826091533,0.8263915926498703,0.08281410978991442,0.9127833576757939,0.039632286792577985,7069]
["High","Q5EBL4-1","RILP-like protein 1 [OS=Homo sapiens]",42,12,26,12,403,47.1,5.21,59.7,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RILPL1","ENSG00000188026; ENSGGOG00000014925","","","",929,987.1,956.2,1123.2,1098.7,1099.6,0.86475989763661,-0.20962847378319022,1.2931690229552712E-3,2.8883447071850723,0.03321402543169328,1.478678486135191,304]
["High","Q5EBM0-1","UMP-CMP kinase 2, mitochondrial [OS=Homo sapiens]",3,1,1,1,449,49.4,7.01,3.06,"other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","kinase activity;other molecular function","CMPK2","ENSG00000134326","Pyrimidine metabolism","","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",92.4,90.1,101.5,82.1,101.3,92.4,1.029731689630167,0.04226847287806423,0.6978370030253183,0.15624600567661823,0.8380054321165311,0.07675316617809068,6502]
["High","Q5HYJ3-1","Protein FAM76B [OS=Homo sapiens]",17,6,9,4,339,38.7,9.25,11.8,"","nucleus","","FAM76B","ENSG00000077458","","","",239.3,250.1,232.7,202,208,199.1,1.1855196191101625,0.24551953811197708,2.7333363792792303E-3,2.563306918371278,0.04521586959621235,1.3447091123467305,472]
["High","Q5JPI3","Uncharacterized protein C3orf38 [OS=Homo sapiens]",19,5,10,5,329,37.5,6.47,16.16,"other biological processes","nucleus","","C3orf38","ENSG00000179021","","","",329.3,362.2,368.4,344,333.1,348.9,1.0330409356725148,0.04689742411739239,0.4337771458240727,0.3627333331516025,0.6543531596975192,0.18418779615361108,5176]
["High","Q5JRA6-1","Transport and Golgi organization protein 1 homolog [OS=Homo sapiens]",41,65,167,64,1907,213.6,4.84,369.78,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MIA3","ENSG00000154305","Type I collagen synthesis in the context of osteogenesis imperfecta","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER","",6768.5,7589.3,7708,6796.2,6426.3,6964.8,1.0930535534717372,0.12836408667805327,0.13537076189733493,0.868475126772258,0.3415104713713703,0.46659597546975945,3095]
["High","Q5JTV8-3","Isoform 3 of Torsin-1A-interacting protein 1 [OS=Homo sapiens]",28,14,38,1,584,66.3,8.18,78.04,"","","","TOR1AIP1","","","","",16.9,20.1,22.4,21.6,18.4,15.8,1.0645161290322582,0.09019780897157845,0.6314828987340615,0.19963840613160422,0.7977056258397593,0.09815734506479419,6181]
["High","Q5M775-1","Cytospin-B [OS=Homo sapiens]",16,16,23,16,1068,118.5,6.7,44.06,"cell organization and biogenesis","other membranes;cytosol;cytoskeleton;nucleus;other cell component","","SPECC1","ENSG00000128487","","","",1118.7,1105.9,1090.3,1202,962.1,1054.1,1.0300478528369899,0.04271136211428882,0.6706402685902944,0.17351037291509896,0.8208746225353533,0.08572317040692401,6379]
["High","Q5PRF9","protein Smaug homolog 2 [OS=Homo sapiens]",30,11,26,11,694,75.4,6.83,54.45,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMD4B","ENSG00000179134","","","",634.4,688.6,700.4,679.6,704,697,0.9725079304046911,-0.04021808015216159,0.4267895160066792,0.36978625746774235,0.648069338969302,0.18837852511594882,5142]
["High","Q5RI15-1","Cytochrome c oxidase protein 20 homolog [OS=Homo sapiens]",22,2,3,2,118,13.3,8.76,10.54,"cell organization and biogenesis","other membranes;mitochondrion","","COX20; FAM36A","ENSG00000203667","Mitochondrial complex IV assembly","TP53 Regulates Metabolic Genes; Respiratory electron transport; Cytoprotection by HMOX1","Thermogenesis",282.7,290,286,293,330.5,322.9,0.9073330515638209,-0.14029588190372466,0.06593271306715141,1.1808990530921806,0.2248046391390036,0.648194730773433,2290]
["Medium","Q5SNT2-1","Transmembrane protein 201 [OS=Homo sapiens]",2,1,1,1,666,72.2,9.22,1.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TMEM201","ENSG00000188807; ENSPTRG00000049393","","","",65.1,49.3,50,54,45.2,43.4,1.152875175315568,0.2052363172377947,0.2998428460162925,0.5231063085827863,0.5373359976348892,0.2697540638599048,4357]
["High","Q5SRD1","Putative mitochondrial import inner membrane translocase subunit Tim23B [OS=Homo sapiens]",14,2,8,2,257,28,9.39,24.02,"","","","","","","","",328.9,315.3,334.6,342.2,461.5,403.5,0.810801855533466,-0.30257870444729346,0.09469373913517443,1.02367873429062,0.2760898861715616,0.5589495023079747,2678]
["High","Q5SYC1-1","Clavesin-2 [OS=Homo sapiens]",6,1,1,1,327,38,6.2,3.32,"cell organization and biogenesis","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLVS2; LOC101343624","ENSAMEG00000028872; ENSCAFG00000001006; ENSCATG00000031634; ENSCSAG00000016282; ENSDLEG00000011174; ENSECAG00000006114; ENSFCAG00000010835; ENSG00000146352; ENSGGOG00000027351; ENSLAFG00000007550; ENSMFAG00000003285; ENSMLEG00000033559; ENSMMUG00000018176; ENSMNEG00000035011; ENSNLEG00000013863; ENSOARG00000008112; ENSPANG00000003404; ENSPCOG00000011744; ENSPPAG00000036654; ENSPPYG00000016981; ENSPTRG00000018566; ENSRBIG00000041651; ENSRROG00000010239; ENSSSUG00005005271; ENSSTOG00000001439; ENSTTRG00000010743; ENSUAMG00000008720; ENSUMAG00000001385; ENSVVUG00000000265","","Lysosome Vesicle Biogenesis; Lysosome Vesicle Biogenesis","",24.9,24.6,23.1,25.6,18.6,23.6,1.0707964601769908,0.09868427485940635,0.49901215671192234,0.301888874158983,0.7059769740182441,0.15120946356561124,5519]
["High","Q5T0D9","Tumor protein p63-regulated gene 1-like protein [OS=Homo sapiens]",21,2,5,2,272,30.2,7.34,18.33,"other biological processes","other membranes;ER/Golgi;other cell component","","TPRG1L","ENSG00000158109","","","",109.9,86,91,87.6,82.9,84,1.1273084479371316,0.1728823118056067,0.21897185177467338,0.6596117089252768,0.448748613820643,0.3479968799422606,3810]
["High","Q5T160","probable arginine--tRNA ligase, mitochondrial [OS=Homo sapiens]",22,11,12,11,578,65.5,8.21,25.19,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","RARS2","ENSG00000146282","","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",478.9,508.4,464,425.8,484.1,475.5,1.0475674895337086,0.06704319254429036,0.38168919084844805,0.4182901387706884,0.6133420872905294,0.2122972331750592,4859]
["High","Q5T2E6-1","UPF0668 protein C10orf76 [OS=Homo sapiens]",5,3,5,3,689,78.7,6.6,10.73,"other biological processes","other membranes;cytosol;ER/Golgi","","ARMH3","ENSG00000120029; ENSNLEG00000014964; ENSPTRG00000002879","","","",155.5,145.7,144.9,159.5,165.2,152.7,0.9344365312107249,-0.09783141830820151,0.10357478932042664,0.9847459414191856,0.28954957214962096,0.5382770724615552,2793]
["Medium","Q5T4F4-1","Protrudin [OS=Homo sapiens]",4,1,1,1,411,45.8,5.15,0,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ZFYVE27","ENSG00000155256","","","Endocytosis",26.9,27.4,31.6,25.9,38.2,31.4,0.899476439790576,-0.15284260178464734,0.45336140985241036,0.3435554498059241,0.6711880713173342,0.1731557706047042,5274]
["High","Q5T5U3-3","Isoform 3 of Rho GTPase-activating protein 21 [OS=Homo sapiens]",6,5,7,1,1164,129.2,8.44,11.46,"","","","","","","","",26.9,25.8,32.7,26.5,32.9,31,0.9446902654867256,-0.08208670279469737,0.591389571922547,0.22812633773418847,0.7689541677887173,0.11409954481447793,6005]
["Medium","Q5T7M9-1","Protein FAM69A [OS=Homo sapiens]",3,1,1,1,428,49,7.17,0,"","other membranes;ER/Golgi","","DIPK1A","ENSG00000154511; ENSPCOG00000022059; ENSPTRG00000000964","","","",61.8,64.7,57.8,43,74.9,58.3,1.0459704880817255,0.06484214671029988,0.7887628396116201,0.10305355817305022,0.8898512139412701,0.050682602755170676,6921]
["High","Q5T8A7","Protein phosphatase 1 regulatory subunit 26 [OS=Homo sapiens]",1,1,1,1,1209,127.3,8.59,3.09,"other biological processes","nucleus","enzyme regulator activity","PPP1R26","ENSG00000196422","","","",22.8,26.6,21.4,33.8,19.1,25.4,0.9042145593869735,-0.14526294720804275,0.6106026532339903,0.2142413129060473,0.7819559646467109,0.10681770326933193,6097]
["High","Q5TAX3","Terminal uridylyltransferase 4 [OS=Homo sapiens]",16,23,37,23,1644,185,7.97,69.36,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TUT4","ENSG00000134744","","Deadenylation of mRNA","",1687,1687.7,1683,1841.1,1759.3,1778.5,0.9402851884214245,-0.08882970243735157,0.012372354571637174,1.9075476423142748,0.09079261700690136,1.0419494656146686,1064]
["High","Q5TC63","Growth hormone-regulated TBC protein 1 [OS=Homo sapiens]",11,3,6,3,336,38.5,8.78,2.46,"transport;other biological processes","","enzyme regulator activity","GRTP1","ENSG00000139835","","","",258.7,261.8,278.3,225.8,305.6,286,0.9772449229263517,-0.033207910576686386,0.8146697304727688,0.08901841985342356,0.9065043830029043,0.042630091723603616,7017]
["High","Q5TFE4","5'-nucleotidase domain-containing protein 1 [OS=Homo sapiens]",40,11,29,11,455,51.8,6.35,39.56,"other metabolic processes","","other molecular function","NT5DC1","ENSG00000178425","","","",1455,1384.2,1329.2,1319.2,1239.4,1276.4,1.0869361147327246,0.12026714766346235,0.061412601730996,1.2117425034404947,0.21726760050549015,0.6630050319435145,2207]
["High","Q5U4P2","Aspartate beta-hydroxylase domain-containing protein 1 [OS=Homo sapiens]",3,1,1,1,390,41.1,8.56,2.56,"protein metabolism;other metabolic processes","other membranes","other molecular function","ASPHD1","ENSG00000174939","16p11.2 proximal deletion syndrome","","",38.5,45.7,48.9,63.8,69.5,54.6,0.7083555082490687,-0.49745449550816373,0.026443482358524773,1.5776813529116418,0.13691691661496116,0.8635428897867616,1508]
["High","Q5VST6-1","Protein ABHD17B [OS=Homo sapiens]",6,2,5,2,288,32.2,6.29,9.62,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","Abhd17b; ABHD17B; FAM108B1; LOC111153563; LOC112838645","ENSAMEG00000007245; ENSBIXG00000020353; ENSBIXG00005014706; ENSBMUG00000011067; ENSBTAG00000006816; ENSCATG00000030905; ENSCHIG00000013948; ENSCSAG00000008296; ENSDLEG00000009276; ENSECAG00000020790; ENSG00000107362; ENSLCNG00005018778; ENSMFAG00000001017; ENSMMUG00000018880; ENSNLEG00000001017; ENSPANG00000025076; ENSPCOG00000021794; ENSPPAG00000033499; ENSPPYG00000019288; ENSRFEG00010009213; ENSRROG00000042653; ENSSBOG00000018778; ENSSSCG00070028547; ENSSSUG00005013616; ENSUAMG00000021312","","RAS processing; RAS processing","",86.3,90.4,95.1,73.3,74,81.2,1.1894967177242886,0.2503512908219589,0.015755731411740727,1.8025614312262581,0.10355282059164275,0.9848380672127975,1188]
["High","Q5VT66-1","Mitochondrial amidoxime-reducing component 1 [OS=Homo sapiens]",31,8,27,7,337,37.5,8.88,56.93,"other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;other cell component","other molecular function","MTARC1","ENSG00000186205","","Phase I - Functionalization of compounds","",624,615.1,636.7,657.9,606.4,648.5,0.9806566290255123,-0.02818002094951553,0.5090147108182673,0.2932696661212442,0.7130224008017638,0.14689682583989416,5574]
["High","Q5VTR2","E3 ubiquitin-protein ligase BRE1A [OS=Homo sapiens]",51,45,129,43,975,113.6,5.94,291.67,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNF20","ENSG00000155827","ATM signaling in development and disease","E3 ubiquitin ligases ubiquitinate target proteins; RHOBTB1 GTPase cycle","",4991.8,5069.2,5173.4,4686.5,4731.9,4688.4,1.0799330819179402,0.11094191852189443,2.343657122196714E-3,2.6301059254313315,0.04245771417659384,1.3720433909334278,431]
["High","Q5VV42","threonylcarbamoyladenosine tRNA methylthiotransferase [OS=Homo sapiens]",23,8,16,8,579,65.1,7.46,36.1,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;ER/Golgi","other molecular function","CDKAL1","ENSG00000145996","Vitamin D receptor pathway","tRNA modification in the nucleus and cytosol","",238.8,217.1,213.8,231.5,229,241,0.9546685673556664,-0.06692813579510638,0.2877042902718577,0.541053661823608,0.5246135213551295,0.28016052012339215,4282]
["High","Q5VWN6-1","Protein FAM208B [OS=Homo sapiens]",7,12,15,12,2430,268.7,5.9,32.35,"","cytosol;nucleus","","TASOR2","ENSG00000108021","","","",531.2,562.1,558.5,586.1,565.5,566.6,0.961354906297288,-0.05685896146255895,0.13467152444640734,0.8707242237509986,0.3404063654508089,0.4680023273938138,3089]
["Low","Q5VYS4-1","Mesenteric estrogen-dependent adipogenesis protein [OS=Homo sapiens]",3,1,1,1,303,34.2,6.3,0,"other biological processes","other cell component","","MEDAG","ENSG00000102802","","","",91,99,104.3,96,88.3,75,1.1349787890474354,0.1826653360871003,0.18286447464118544,0.7378706573768342,0.4036770760526932,0.39396591253295044,3537]
["High","Q5VZL5","Zinc finger MYM-type protein 4 [OS=Homo sapiens]",17,22,51,21,1548,172.7,6.84,94.29,"cell organization and biogenesis;developmental processes;other biological processes","","nucleic acid binding activity;other molecular function","ZMYM4","ENSG00000146463","","","",2031.5,1990.6,1983.6,2135,2278,2168.1,0.9125678078132833,-0.1319963334194922,0.013758006301990134,1.8614444959535121,0.09677703892426934,1.014227670081534,1110]
["High","Q5XUX0-1","F-box only protein 31 [OS=Homo sapiens]",3,1,1,1,539,60.6,7.02,3.8,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","FBXO31","ENSG00000103264","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",27.3,22.7,20.6,15.5,18.6,14.6,1.4496919917864475,0.5357464111888379,0.034626937643845404,1.4605859151264817,0.15682548092989845,0.8045833719565403,1724]
["High","Q63HQ0","AP-1 complex-associated regulatory protein [OS=Homo sapiens]",7,3,5,3,302,34.3,4.87,9.71,"transport;other biological processes","cytosol;ER/Golgi;other cytoplasmic organelle","cytoskeletal activity;other molecular function","AP1AR","ENSG00000138660","","","",239.3,227.8,244.8,214.3,203.2,210.9,1.1328771483131765,0.17999142062090814,0.009678464363487438,2.0141935446925596,0.08125747284958056,1.0901366885878594,930]
["High","Q66K64","DDB1- and CUL4-associated factor 15 [OS=Homo sapiens]",12,5,8,5,600,66.4,6.58,21.51,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","DCAF15","ENSG00000132017; ENSG00000288453","","","",332.6,315.9,319.4,352.8,360.3,356.6,0.904833130784332,-0.1442763398045642,3.5669992160288332E-3,2.4476969861128346,0.05176789940288686,1.2859394571205882,538]
["High","Q676U5","Autophagy-related protein 16-1 [OS=Homo sapiens]",21,11,18,11,607,68.2,6.64,40.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","ATG16L1","ENSG00000085978; ENSG00000281089","Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy","Macroautophagy","Autophagy; Autophagy; NOD-like receptor signaling pathway; Shigellosis",662.7,679.7,674.5,732.3,638.1,672.9,0.9870797239759214,-0.018761482607166077,0.768669790268078,0.11426018693864876,0.8789943940265309,0.05601389472270938,6828]
["High","Q68CP9-1","AT-rich interactive domain-containing protein 2 [OS=Homo sapiens]",10,15,23,15,1835,197.3,7.42,48.14,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;nucleus","nucleic acid binding activity;other molecular function","ARID2","ENSG00000189079","","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Hepatocellular carcinoma",885,860.5,869.8,982,1070.8,1038.3,0.8460742130633108,-0.24114388056978672,4.1417733367742245E-3,2.3828136720484903,0.05585313681093808,1.252952431117291,579]
["High","Q68D06","Schlafen family member 13 [OS=Homo sapiens]",3,2,2,2,897,102,6.96,6.51,"RNA metabolism OR transcription;other metabolic processes;stress response","other cell component","nucleic acid binding activity;other molecular function","SLFN13","ENSG00000154760","","","",65.9,61.3,68.5,57.1,69.3,71.1,0.9908860759493672,-0.013208897325023623,0.9079887387218043,0.041919537757888266,0.9564997398731581,0.019315143746112845,7412]
["High","Q68E01-2","Isoform 2 of Integrator complex subunit 3 [OS=Homo sapiens]",12,10,34,10,1042,117.9,5.8,83.06,"","","","INTS3","","","","",955.1,946.3,975.7,1028.4,1036.5,1046.6,0.9246665595372007,-0.11299488020653123,1.5488849872529718E-3,2.8099808296622517,0.03578015970553611,1.4463577252812712,338]
["High","Q69YN2-1","CWF19-like protein 1 [OS=Homo sapiens]",18,6,14,6,538,60.6,7.24,36.93,"RNA metabolism OR transcription;other metabolic processes","nucleus","enzyme regulator activity","CWF19L1","ENSG00000095485","","","",308.4,317.7,313.2,340,320.1,336.9,0.9421263791374122,-0.08600749542573227,0.046222186623732085,1.3351495132887938,0.18574515345244474,0.7310825092299409,1943]
["High","Q6AI39","BRD4-interacting chromatin-remodeling complex-associated protein-like [OS=Homo sapiens]",2,2,2,2,1079,115,6.87,2.43,"other biological processes","nucleus","","BICRAL","ENSG00000112624","","","",73.8,73.2,62.9,86.5,76.6,92.2,0.8221699960830395,-0.2824913711149646,0.05860883801451314,1.2320368889048088,0.21245023547693526,0.6727427832081363,2154]
["High","Q6DD88","Atlastin-3 [OS=Homo sapiens]",24,9,18,9,541,60.5,5.66,40.43,"cell organization and biogenesis;other biological processes","other membranes;ER/Golgi","other molecular function","ATL3","ENSG00000184743","","","",751.1,785.6,779,844.8,854.4,883,0.8967934319572458,-0.15715238288743175,0.004700495679756092,2.327856342142577,0.057980205793895054,1.236720247501297,633]
["High","Q6F5E8","capping protein, Arp2/3 and myosin-I linker protein 2 [OS=Homo sapiens]",9,9,10,9,1435,154.6,6.76,20.36,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","CARMIL2","ENSG00000159753","","","",226.7,249.7,252.9,312.6,247.3,256.1,0.8937499999999998,-0.16205675810897324,0.26033929432873626,0.5844602766767858,0.4955458825252981,0.3049161280504979,4102]
["High","Q6I9Y2","THO complex subunit 7 homolog [OS=Homo sapiens]",19,3,3,3,204,23.7,5.67,5.61,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","THOC7","ENSG00000163634","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","Nucleocytoplasmic transport",178.6,194.5,169.1,190.5,182.9,168.2,1.0011078286558348,1.5973742627153375E-3,0.9848290376732058,0.006639154719994941,0.9941234810798179,2.5596680967458823E-3,7735]
["High","Q6IBS0","Twinfilin-2 [OS=Homo sapiens]",44,13,48,10,349,39.5,6.84,110.24,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","TWF2","ENSG00000247596","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",1789.1,1856.7,1920.4,1661.8,1841.9,1711.5,{"$f":"AVERAGE(T3906:V3906)/AVERAGE(W3906:Y3906)","v":1.0673032673722966},{"$f":"LOG(Z3906,2)","v":0.09397016694828557},{"$f":"TTEST(T3906:V3906,W3906:Y3906,2,2)","v":0.1497018680100807},{"$f":"-LOG10(AB3906)","v":0.8247727804090612},{"$f":"AB3906*7808/AF3906","v":0.36266589681126593},{"$f":"-LOG10(AD3906)","v":0.44049328126276033},3223]
["Medium","Q6IQ26","DENN domain-containing protein 5A [OS=Homo sapiens]",2,1,1,1,1287,147,6.65,0,"transport;other biological processes","other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","DENND5A","ENSG00000184014","","RAB GEFs exchange GTP for GDP on RABs","",17.6,13.4,10.5,10.1,13.1,16.5,1.0453400503778336,0.06397232909132913,0.839038183720406,0.07621827444933502,0.9214078957087102,0.035548070520465935,7110]
["Medium","Q6IQ55","tau-tubulin kinase 2 [OS=Homo sapiens]",1,1,1,1,1244,137.3,7.01,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","TTBK2","ENSG00000128881","Genes related to primary cilium development (based on CRISPR); Ciliopathies","Anchoring of the basal body to the plasma membrane","",78.5,89.6,101,75.8,74,76.2,1.19070796460177,0.2518196183378674,0.092660450614727,1.033105592121062,0.27384284572285705,0.5624986007409349,2642]
["High","Q6N075","Molybdate-anion transporter [OS=Homo sapiens]",3,1,4,1,450,49.7,7.8,0,"transport","plasma membrane;other membranes","transporter activity","MFSD5","ENSG00000182544","","","",96.3,90.3,85.9,89.5,104.6,101,0.9234157912572009,-0.11494769088035624,0.23982505605415785,0.6201054453506039,0.47167608001785,0.32635614745508357,3970]
["Medium","Q6NT16","MFS-type transporter SLC18B1 [OS=Homo sapiens]",2,1,1,1,456,48.8,5.22,0,"transport","other membranes","transporter activity","SLC18B1","ENSG00000146409","","","",15.5,9.8,15.8,15.7,16.9,11.6,0.9298642533936653,-0.10490797570974847,0.7035193320925738,0.1527239640348183,0.841464299169549,0.07496430512198765,6528]
["High","Q6NUQ4","Transmembrane protein 214 [OS=Homo sapiens]",15,8,20,8,689,77.1,9.14,37.79,"other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi","","TMEM214","ENSG00000119777","","","",911.7,862.3,874,829.5,840.5,895.7,1.0320770160190202,0.04555063208184336,0.33971450025758165,0.4688859154571598,0.5762526217708446,0.2393870856924986,4603]
["High","Q6NW29","RWD domain-containing protein 4 [OS=Homo sapiens]",11,2,5,2,188,21.2,5.31,10.8,"","","","RWDD4","ENSG00000182552","","","",204.6,179.9,179.6,199.4,176.3,182,1.0114757037833961,0.01646166596422537,0.8531993194695591,0.06894949962524967,0.928471120058302,0.03223160037264422,7175]
["High","Q6NYC1","Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 [OS=Homo sapiens]",15,5,11,5,403,46.4,8.69,32.12,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","JMJD6","ENSG00000070495","","HDMs demethylate histones","",327.3,316.3,313.6,348.1,391.9,359,0.8709736123748862,-0.1992990842980946,0.02674896271117726,1.5726930546725253,0.1375862324432622,0.8614250215733515,1518]
["High","Q6P1A2","Lysophospholipid acyltransferase 5 [OS=Homo sapiens]",10,4,10,4,487,56,8.69,17.01,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","LPCAT3","ENSG00000111684","Ferroptosis","Acyl chain remodelling of PC; Acyl chain remodelling of PS; Acyl chain remodelling of PE","Glycerophospholipid metabolism; Ferroptosis",338.1,357.3,354.9,275.9,366.4,339.2,1.0700967906265921,0.09774129479612731,0.450929508379174,0.3458913439639441,0.668983013761085,0.17458490932258622,5263]
["High","Q6P1M0","Long-chain fatty acid transport protein 4 [OS=Homo sapiens]",16,7,9,7,643,72,8.47,24.82,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","SLC27A4","ENSG00000167114","PPAR signaling pathway; Fatty acid transporters","Transport of fatty acids; Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)","PPAR signaling pathway; Insulin resistance; Fat digestion and absorption",210.2,226.6,209.1,206,227.2,233.2,0.9692376950780311,-0.045077580477157805,0.5321080314711865,0.27400018592155806,0.7268543578948607,0.1385526013818553,5716]
["High","Q6P1R4","tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like [OS=Homo sapiens]",16,5,5,5,473,53.2,8.29,5.5,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","DUS1L","ENSG00000169718","","","",159.3,127.5,125.5,125.4,131.7,127.4,1.0723016905071523,0.10071086303887615,0.4509670127849901,0.34585522461738905,0.6689115569576752,0.17463130056465273,5264]
["High","Q6P4A8","Phospholipase B-like 1 [OS=Homo sapiens]",10,4,14,4,553,63.2,9.06,29.02,"other metabolic processes","non-structural extracellular;cytosol;other cytoplasmic organelle","other molecular function","PLBD1","ENSG00000121316","","Acyl chain remodelling of PC; Acyl chain remodelling of PE; Acyl chain remodelling of PI; Hydrolysis of LPC","",513.2,502.2,499,519.8,510.4,542.8,0.9627463445645266,-0.054772354599343556,0.13749560531609703,0.8617111826880453,0.3446438800346984,0.46262942902459825,3115]
["High","Q6P4E1","Protein CASC4 [OS=Homo sapiens]",15,6,10,6,433,48.8,5.82,17.92,"","","","","","","","",289.1,291,274.5,258.9,269,275.2,1.0641265097746233,0.08966967731917762,0.07164856797793741,1.1447924853154123,0.23734918064138114,0.6246122631811007,2357]
["High","Q6P9B6","TLD domain-containing protein 1 [OS=Homo sapiens]",12,4,7,4,456,51,6.24,17.31,"signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","","MEAK7","ENSG00000140950","","","",367.9,373.2,370.8,376.7,339.3,361.9,1.0315428147323498,0.04480370229095212,0.3603791280830196,0.4432403698041296,0.5971647351596386,0.2239058469245394,4712]
["High","Q6PCT2-1","F-box/LRR-repeat protein 19 [OS=Homo sapiens]",2,2,3,2,694,75.7,9.17,1.75,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","FBXL19","ENSG00000099364; ENSGGOG00000003625; ENSPTRG00000008021","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",169.9,185.7,186.9,226.8,197.7,210.3,0.8545998739760555,-0.2266789906159778,0.03760406264753386,1.4247652324634938,0.16329951120797798,0.7870151152020682,1798]
["High","Q6PD74","Alpha- and gamma-adaptin-binding protein p34 [OS=Homo sapiens]",18,4,21,4,315,34.6,4.64,69.18,"transport","cytosol;nucleus;other cell component","","AAGAB","ENSG00000103591","","","",775.4,766.6,799.9,748.7,774.5,705.7,1.050697653551079,0.07134758226341822,0.16800431795057755,0.7746795561431234,0.38457276885315433,0.4150214708918853,3411]
["High","Q6PIW4","Fidgetin-like protein 1 [OS=Homo sapiens]",16,7,9,6,674,74,7.85,16.75,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","FIGNL1","ENSG00000132436","","","",153.5,152.1,175.7,155.2,195.5,167.6,0.9286127725255644,-0.10685097041982689,0.432846063902714,0.3636665273972492,0.653832862633467,0.1845332549063048,5169]
["High","Q6PJW8","Consortin [OS=Homo sapiens]",8,4,6,4,725,79.5,4.53,11.79,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","CNST","ENSG00000162852","","","",304.3,295.3,310.4,288.7,252.8,273.5,1.1165644171779139,0.15906648596761844,0.04857756082400841,1.3135642957735476,0.19117620711383954,0.7185661589330721,1984]
["High","Q6PL24","Protein TMED8 [OS=Homo sapiens]",13,3,5,3,325,35.7,4.74,10.14,"","","","TMED8","ENSG00000100580","","","",82.2,90,86.1,80.1,76.8,73.4,1.1215805471124618,0.16553323232515432,0.03470438960689853,1.4596155897196825,0.15699413328543668,0.804116576440238,1726]
["High","Q6RFH5-1","WD repeat-containing protein 74 [OS=Homo sapiens]",48,12,22,12,385,42.4,8.32,50.14,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","","WDR74","ENSG00000133316","","","",743.3,703.1,719.9,802.2,763.2,791.4,{"$f":"AVERAGE(T4034:V4034)/AVERAGE(W4034:Y4034)","v":0.9191700610997964},{"$f":"LOG(Z4034,2)","v":-0.12159628711903994},{"$f":"TTEST(T4034:V4034,W4034:Y4034,2,2)","v":0.018192671744225983},{"$f":"-LOG10(AB4034)","v":1.7401035165182284},{"$f":"AB4034*7808/AF4034","v":0.11246902690333846},{"$f":"-LOG10(AD4034)","v":0.9489670624149237},1263]
["High","Q6UB35-1","Monofunctional C1-tetrahydrofolate synthase, mitochondrial [OS=Homo sapiens]",22,20,54,19,978,105.7,8.06,110.51,"other metabolic processes;developmental processes","cytosol;mitochondrion","other molecular function","MTHFD1L","ENSG00000120254","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism","Metabolism of folate and pterines","One carbon pool by folate; Metabolic pathways; Biosynthesis of cofactors",2022.1,2021,2007.8,2031.4,2071.1,2039.1,0.9852318614041943,-0.021464810994289554,0.0805457883306554,1.0939571635324885,0.2538964534863776,0.59534336545969,2477]
["High","Q6ULP2","Aftiphilin [OS=Homo sapiens]",9,6,9,6,937,102.1,4.54,14.03,"","","","","","","","",235.7,258,255.1,237.4,221,212.9,1.1154476389095784,0.1576227925076696,0.061893339919301515,1.2083560810592393,0.2171969429617556,0.6631462917175545,2225]
["High","Q6UW68","Transmembrane protein 205 [OS=Homo sapiens]",9,1,5,1,189,21.2,8.62,8.89,"","other membranes","","TMEM205","ENSG00000105518","","","",76.4,71.4,71.4,72,72.3,61.3,1.066147859922179,0.09240753376664859,0.318610426106991,0.49674001658684375,0.555664553728699,0.25518730631165343,4477]
["High","Q6UWZ7","BRCA1-A complex subunit Abraxas 1 [OS=Homo sapiens]",9,4,5,4,409,46.6,7.05,6.94,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","cytoskeletal activity;other molecular function","ABRAXAS1","ENSG00000163322","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Homologous recombination",335.6,338.5,355.2,396.3,349.7,374.8,0.9183618843683083,-0.12286532915200732,0.10811388552938914,0.9661185241639902,0.29598640189813125,0.5287282406851828,2852]
["Medium","Q6UX68","XK-related protein 5 [OS=Homo sapiens]",1,1,1,1,686,74.9,6.68,0,"","","","","","","","",16.6,13.3,14.7,16.8,22.1,20,0.7572156196943972,-0.4012239239101561,0.058284287824303324,1.2344485058050194,0.21176534170877634,0.6741451166378273,2149]
["High","Q6V1X1","Dipeptidyl peptidase 8 [OS=Homo sapiens]",6,5,5,4,898,103.3,5.8,13.75,"protein metabolism;other biological processes","cytosol;other cell component","other molecular function","DPP8","ENSG00000074603","","","",275.5,272.9,275.5,264.1,260.7,255.7,1.0556053811659192,0.07807061023077698,5.0309518725574365E-3,2.298349837232532,0.05988059789775681,1.222713871949557,656]
["High","Q6VEQ5","WAS protein family homolog 2 [OS=Homo sapiens]",11,4,8,4,465,50.3,5.71,11.75,"cell organization and biogenesis;transport","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity","WASH2P","","","","",290.1,311.9,295.7,332.4,297.9,287.6,0.9779932454515744,-0.03210359370491286,0.6775781186084686,0.16904062735420752,0.8249695852323286,0.08356206261281124,6413]
["High","Q6XZF7","Dynamin-binding protein [OS=Homo sapiens]",5,5,5,5,1577,177.2,5.39,9.6,"signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity","DNMBP","ENSG00000107554","","CDC42 GTPase cycle","",72.6,73.9,73.4,58.5,57.1,62.4,1.2353932584269662,0.3049703630012079,0.001019446087726636,2.991635736459578,0.030037113407432356,1.5223418057377502,265]
["High","Q6Y7W6-1","GRB10-interacting GYF protein 2 [OS=Homo sapiens]",34,41,102,40,1299,150,5.54,190.35,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GIGYF2","ENSG00000204120","VEGFA-VEGFR2 signaling pathway","","",3418,3966.1,3887.5,4138.3,3581,3682.8,0.9885547399163312,-0.016607239383788244,0.8661669945784023,0.062398369146433104,0.9342494672839018,0.029537141116245967,7239]
["High","Q6ZN17-1","Protein lin-28 homolog B [OS=Homo sapiens]",44,9,24,7,250,27.1,8.91,34.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","LIN28B","ENSG00000187772","Cardiac progenitor differentiation; Hippo-Merlin signaling dysregulation; Malignant pleural mesothelioma; CCL18 signaling pathway","","",531.2,551.6,533.3,650.3,559.4,555.2,0.9156892741798404,-0.12706997107420942,0.1926306214478021,0.715274674279298,0.41514211765510317,0.38180320365519943,3623]
["High","Q6ZPD9-1","probable C-mannosyltransferase DPY19L3 [OS=Homo sapiens]",7,3,4,3,716,83.1,8.72,8.3,"protein metabolism;other metabolic processes","other membranes;nucleus","other molecular function","DPY19L3","ENSG00000178904; ENSPPAG00000028384","","","",24.3,27.3,26.8,23.2,21.1,17.7,1.2645161290322582,0.3385854388409708,0.04187763201775524,1.3780178836001014,0.17513687776895173,0.7566223968905442,1867]
["High","Q6ZRS2","Helicase SRCAP [OS=Homo sapiens]",5,14,28,13,3230,343.3,5.96,54.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","SRCAP","ENSG00000080603","Pathways affected in adenoid cystic carcinoma","","",689.1,750.2,814.3,768.7,716.3,751.4,1.0076909318547667,0.011053218745668808,0.8910546702047584,0.050095649229267375,0.9495502750046068,0.02248203610963748,7327]
["High","Q6ZTU2","EP400 N-terminal-like protein [OS=Homo sapiens]",5,1,1,1,488,51.7,7.27,0,"","","","EP400P1","","","","",19.7,19.1,22.7,19.4,15,14.8,1.2499999999999998,0.32192809488736207,0.09331303118096207,1.030057702718665,0.27442114781956756,0.5615824234775174,2655]
["High","Q6ZV29-1","Patatin-like phospholipase domain-containing protein 7 [OS=Homo sapiens]",1,2,4,1,1317,145.6,7.74,0,"","","","","","","","",26,18.3,20.2,24.9,30,22.4,0.8344113842173351,-0.26116925361423093,0.2557007042017931,0.5922680759215263,0.4901819539424504,0.30964268134888856,4073]
["High","Q6ZW49","PAX-interacting protein 1 [OS=Homo sapiens]",4,4,7,4,1069,121.3,6.7,24.58,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","","PAXIP1","ENSG00000157212","16p11.2 proximal deletion syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nonhomologous End-Joining (NHEJ)","",103.6,117.3,108.4,114,113.2,113.7,0.9659724259313581,-0.0499460875445988,0.3906145504258375,0.4082515832397817,0.6204065113354229,0.20732365279556278,4916]
["Medium","Q70CQ4-1","Ubiquitin carboxyl-terminal hydrolase 31 [OS=Homo sapiens]",1,2,2,2,1352,146.6,9.22,2.03,"protein metabolism;other metabolic processes","nucleus","other molecular function","USP31","ENSG00000103404","","","",70.1,55.6,64.1,52.4,57.8,54.6,1.1516990291262135,0.20376374983789086,0.13697990324852516,0.8633431448763509,0.34357182286041904,0.46398246090023076,3113]
["High","Q70UQ0","Inhibitor of nuclear factor kappa-B kinase-interacting protein [OS=Homo sapiens]",20,8,17,5,350,39.3,9.17,28.46,"other biological processes","other membranes;ER/Golgi","","IKBIP","ENSG00000166130","","","",799.6,723.7,811.7,754.5,775.8,817.2,0.9946751863684772,-7.702607944112488E-3,0.9059685921927776,0.04288685803378314,0.9551448511802872,0.01993076108857153,7406]
["High","Q712K3","Ubiquitin-conjugating enzyme E2 R2 [OS=Homo sapiens]",8,3,8,3,238,27.1,4.42,16.66,"protein metabolism;other metabolic processes","cytosol","other molecular function","UBE2R2","ENSG00000107341","","Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes","Ubiquitin mediated proteolysis",463.8,470,439,560,518.8,506.6,0.8659013498170808,-0.2077254235572925,0.019364077877738143,1.713003179398018,0.11594687121884925,0.935740966135284,1304]
["High","Q71UM5","40S ribosomal protein S27-like [OS=Homo sapiens]",39,3,17,1,84,9.5,9.45,25.77,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;translational apparatus;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPS27L","ENSG00000185088","","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",246.8,204.2,179.9,213.7,186.1,213.2,1.029200652528548,0.041524276874791474,0.7958077346249806,0.09919184416848868,0.8945676348908507,0.04838681848459676,6946]
["High","Q76NI1-1","Protein very KIND [OS=Homo sapiens]",3,4,4,4,1749,191.3,6.16,8.25,"developmental processes;signal transduction;other biological processes","other cell component","enzyme regulator activity","KNDC1","ENSG00000171798","","","",165,165.8,171.6,203.9,192.9,184.7,0.8639724849527085,-0.2109427274689537,0.011332394099176347,1.9456783307169463,0.08691879481961583,1.0608863040590508,1018]
["High","Q7KZF4","staphylococcal nuclease domain-containing protein 1 [OS=Homo sapiens]",55,49,244,49,910,101.9,7.17,624.26,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SND1","ENSG00000197157","VEGFA-VEGFR2 signaling pathway","Signaling by BRAF and RAF1 fusions","Viral carcinogenesis",8865.2,8853.3,8890.6,8292.7,8623.4,8547.3,1.044993991375857,0.06349464695957865,0.019163538181525736,1.717524303668186,0.11563284862546595,0.9369187753422322,1294]
["High","Q7L190","Developmental pluripotency-associated protein 4 [OS=Homo sapiens]",54,15,66,15,304,33.5,9.52,153.1,"developmental processes","nucleus","other molecular function","DPPA4","ENSG00000121570","","POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","",3713.8,3618.6,3597.4,4729.3,4706.9,4642.2,0.7763524264120922,-0.36521638008437296,1.8832428644560041E-5,4.725093669419474,0.0091902251785453,2.036673847416763,16]
["Low","Q7L211","Protein Abhd13 [OS=Homo sapiens]",2,1,1,1,337,38.5,8.57,1.73,"protein metabolism;other metabolic processes","other membranes;other cell component","other molecular function","ABHD13","ENSG00000139826","","","",36.9,45.2,45.3,49.1,46.5,37.5,0.9571750563486099,-0.06314529365559167,0.6935039795651227,0.158951042451959,0.8352428000068607,0.07818725939622737,6483]
["High","Q7L3B6","Hsp90 co-chaperone Cdc37-like 1 [OS=Homo sapiens]",15,5,10,5,337,38.8,5.34,21.18,"other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","CDC37L1","ENSG00000106993","","Platelet degranulation","",523.9,568.3,576,481.2,445.6,451.5,1.2103315678734672,0.27540232501978573,7.90030989625253E-3,2.102355872811739,0.07513473772221652,1.1241592252725445,821]
["High","Q7L5N7","Lysophosphatidylcholine acyltransferase 2 [OS=Homo sapiens]",6,3,4,3,544,60.2,6.55,8.36,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","LPCAT2","ENSG00000087253","","Acyl chain remodelling of PC","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways",131,133.5,126.7,107.3,120,121.2,1.1225251076040172,0.16674771419644832,0.04313120437722984,1.3652084146321097,0.17837311640752676,0.7486705999355246,1888]
["High","Q7L7L0","Histone H2A type 3 [OS=Homo sapiens]",35,6,156,1,130,14.1,11.05,351.11,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","H2AW","ENSG00000181218; ENSG00000284841","","HATs acetylate histones; HCMV Early Events; HCMV Late Events; Ub-specific processing proteases; UCH proteinases; RMTs methylate histone arginines; HDACs deacetylate histones; Metalloprotease DUBs","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus",72.5,22.7,17,31.1,21.5,32,1.326241134751773,0.4073431074888431,0.6351778245097479,0.19710467251603986,0.7990121562384584,0.0974466132428015,6207]
["High","Q7LGA3-1","Heparan sulfate 2-O-sulfotransferase 1 [OS=Homo sapiens]",18,5,8,5,356,41.9,8.69,17.7,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","HS2ST1","ENSG00000153936; ENSGGOG00000040966; ENSPPAG00000039539; ENSPTRG00000000927","Metapathway biotransformation Phase I and II","HS-GAG biosynthesis","Glycosaminoglycan biosynthesis",415.5,420.9,432.4,410.1,395.9,382,1.068013468013468,0.09492984001585038,0.04739230877256034,1.3242921336141886,0.1880280217968248,0.7257774230508759,1968]
["High","Q7RTS7","Keratin, type II cytoskeletal 74 [OS=Homo sapiens]",5,3,14,1,529,57.8,7.71,19.02,"cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","KRT74","ENSG00000170484","","Formation of the cornified envelope","",136,90.9,115.5,136.9,105,139.4,0.8979805927091528,-0.15524382932496836,0.490628778274423,0.30924698144715146,0.7004625161394579,0.15461510016315477,5469]
["High","Q7Z2W9","39S ribosomal protein L21, mitochondrial [OS=Homo sapiens]",42,6,14,6,205,22.8,9.89,31.77,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL21","ENSG00000197345","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",362.4,390.5,375.4,361.5,394.8,381.2,0.9919120879120877,-0.011715833099321032,0.820012581038074,0.08617948440470138,0.909081106452546,0.041397368138397235,7043]
["Low","Q7Z3D4","LysM and putative peptidoglycan-binding domain-containing protein 3 [OS=Homo sapiens]",4,1,1,1,306,34.5,5.97,0,"cell organization and biogenesis","plasma membrane;other membranes;ER/Golgi","","LYSMD3","ENSG00000176018","","","",32.6,35.3,39.2,31.8,29.4,37.3,1.0873096446700508,0.12076285040651726,0.3966635761363208,0.40157767703848657,0.6255603317455853,0.2037307987113352,4951]
["High","Q7Z3E2","Coiled-coil domain-containing protein 186 [OS=Homo sapiens]",7,5,7,5,898,103.6,6.27,13.45,"cell-cell signaling;transport;other biological processes","ER/Golgi","other molecular function","CCDC186","ENSG00000165813","","","",208,240.9,219.3,234.4,210.7,221.2,1.0028515683625996,0.00410808906683363,0.9599016787894178,0.017773248779181967,0.9812663404016463,0.00821309815784558,7638]
["High","Q7Z408","CUB and sushi domain-containing protein 2 [OS=Homo sapiens]",0,1,1,1,3487,379.8,6.09,2.32,"","plasma membrane;other membranes","","CSMD2","ENSG00000121904","","","",29.9,32.3,24.2,34.9,34.1,31,0.8639999999999999,-0.2108967824986187,0.16603929960370828,0.7797891072550105,0.3819784476445946,0.4179611405780322,3394]
["High","Q7Z4H8","KDEL motif-containing protein 2 [OS=Homo sapiens]",19,9,16,9,507,58.5,8.24,29.07,"protein metabolism;other metabolic processes","ER/Golgi;other cell component","other molecular function","POGLUT3","ENSG00000178202","","","",827.2,828.7,874.5,960.6,989.2,964.4,0.8683000480406285,-0.2037344312274848,2.0389518923421045E-3,2.690593020978523,0.040000342651776766,1.3979362883935755,398]
["High","Q7Z4L5","Tetratricopeptide repeat protein 21B [OS=Homo sapiens]",7,7,7,7,1316,150.8,6.96,16,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","TTC21B","ENSG00000123607","Nephrotic syndrome; Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",245.1,243.4,232.7,201.8,243.8,232.9,1.0629329403095062,0.08805058112612513,0.3405577687626555,0.4678092081951462,0.5765557368817897,0.23915870215917218,4612]
["High","Q7Z4W1","L-xylulose reductase [OS=Homo sapiens]",58,10,24,10,244,25.9,8.1,64.3,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","DCXR","ENSG00000169738","","Formation of xylulose-5-phosphate; Essential pentosuria","Pentose and glucuronate interconversions; Metabolic pathways",675.9,729.4,738.8,408.9,468.6,442.5,1.6243181818181818,0.6998342645233836,0.000462299545413922,3.3350765336099872,0.02110897573445557,1.6755328393435056,171]
["High","Q7Z624","Calmodulin-lysine N-methyltransferase [OS=Homo sapiens]",7,2,4,2,323,36.1,6.83,7.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","CAMKMT","ENSG00000143919","","Inactivation, recovery and regulation of the phototransduction cascade; Protein methylation","Lysine degradation; Metabolic pathways",180.2,168.2,162.3,158.1,195.6,156.2,1.0015689350853108,0.002261721083856448,0.9855787007614689,6.3086905709991885E-3,0.99449450704905,2.3976112975899713E-3,7738]
["High","Q7Z628","Neuroepithelial cell-transforming gene 1 protein [OS=Homo sapiens]",10,4,5,4,596,67.7,9.23,11.26,"stress response;signal transduction;other biological processes","cytosol;nucleus","enzyme regulator activity","NET1","ENSG00000173848","Apoptosis-related network due to altered Notch3 in ovarian cancer","RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events","",150.8,152.3,147.9,154.6,186.4,149.8,0.9189079054604727,-0.12200781552016164,0.31495541012789907,0.5017509271823007,0.5518787796855108,0.25815630468933776,4456]
["High","Q7Z6M1-1","Rab9 effector protein with Kelch motifs [OS=Homo sapiens]",20,6,9,6,372,40.5,6.25,17.75,"transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","RABEPK","ENSG00000136933","","Retrograde transport at the Trans-Golgi-Network","",519.7,533.5,533.5,502.2,527.2,513,1.0287214730290457,0.04085242453253247,0.16023762073949127,0.7952355122128657,0.3760551075244809,0.4247485084230528,3327]
["High","Q7Z739","YTH domain-containing family protein 3 [OS=Homo sapiens]",19,10,30,6,585,63.8,9.04,50.5,"cell organization and biogenesis;other biological processes","cytosol;other cell component","translation activity;nucleic acid binding activity","YTHDF3","ENSG00000185728","","","",783.3,787.4,806.1,777.5,728.7,763.9,1.047002334698912,0.06626465932200384,0.09234539768290391,1.0345847440864921,0.2736367609518458,0.5628255589764222,2635]
["High","Q7Z7H5","Transmembrane emp24 domain-containing protein 4 [OS=Homo sapiens]",34,7,49,5,227,25.9,8.28,112.09,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED4","ENSG00000158604","","","",760.3,736.8,790.8,756.4,803,753.8,0.9890627701884834,-0.015866011348909782,0.7251816149717846,0.13955321480476351,0.8539010782234496,0.06859243805813693,6631]
["High","Q86SQ9","Dehydrodolichyl diphosphate synthase complex subunit DHDDS [OS=Homo sapiens]",17,4,7,4,333,38.6,8.28,10.61,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DHDDS","ENSG00000117682","","Synthesis of Dolichyl-phosphate; Defective DHDDS causes retinitis pigmentosa 59","Terpenoid backbone biosynthesis",100.4,100.6,97.7,95.7,85.9,95.8,1.0767844268204756,0.10672944998718745,0.10606401726045837,0.9744319276510922,0.2934613206129195,0.532449132410786,2822]
["High","Q86TB9","Protein PAT1 homolog 1 [OS=Homo sapiens]",18,8,9,8,770,86.8,6.67,25.84,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","PATL1","ENSG00000166889","","mRNA decay by 5' to 3' exoribonuclease","RNA degradation",290.6,316.8,314,320.7,284.6,300.5,1.0172223448884965,0.024635058554099528,0.7166583307668628,0.14468784632453296,0.849888858843813,0.07063786387011098,6584]
["High","Q86TM6","E3 ubiquitin-protein ligase synoviolin [OS=Homo sapiens]",8,4,9,4,617,67.6,6.95,9.07,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","SYVN1","ENSG00000162298","","Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; XBP1(S) activates chaperone genes; ER Quality Control Compartment (ERQC)","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",317.3,281.6,288.2,265.5,247.9,268.9,1.1339639524479102,0.18137477921203757,0.051938897468781456,1.2845072735805398,0.1987935840373753,0.7015976363478033,2040]
["High","Q86U42-1","polyadenylate-binding protein 2 [OS=Homo sapiens]",69,14,44,14,306,32.7,5.06,93.31,"RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BCL2L2; BCL2L2-PABPN1; LOC101332651; LOC102975296; LOC106988220; LOC109255027; LOC110585402; LOC111164107; LOC112822568; LOC116541350; PABPN1","ENSCATG00000038536; ENSCCAG00000033954; ENSCJAG00000007960; ENSDLEG00000019901; ENSFCAG00000031922; ENSG00000100836; ENSGGOG00000022683; ENSMMUG00000014747; ENSMNEG00000045065; ENSOGAG00000008710; ENSPANG00000021100; ENSPTRG00000006167; ENSSSCG00000002023","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA surveillance pathway; Influenza A",1987.9,2045.8,1954.6,2419.8,2286.8,2371.9,0.8459843187115913,-0.24129717329946027,1.5242533935874113E-3,2.8169428293946788,0.035526479095911966,1.4494478317728885,335]
["High","Q86U90","YrdC domain-containing protein, mitochondrial [OS=Homo sapiens]",11,2,4,2,279,29.3,8.57,12.78,"other biological processes","other membranes;mitochondrion;other cell component","nucleic acid binding activity;other molecular function","YRDC","ENSG00000196449","","","",299,283.8,304.4,300.9,293.6,284.5,1.009328782707622,0.013396200130943184,0.7430793111164489,0.12896483019368424,0.8645452631794417,0.06321226435134093,6711]
["High","Q86UK7-1","E3 ubiquitin-protein ligase ZNF598 [OS=Homo sapiens]",16,12,23,12,904,98.6,8.4,54.84,"protein metabolism;other metabolic processes","","translation activity;other molecular function","ZNF598","","","","",719.1,811.6,706.5,710.9,632.1,664,1.1146985550572992,0.15665361873560113,0.12940785383044545,0.8880393653078265,0.33215533290865157,0.4786587703661706,3042]
["High","Q86UV5","Ubiquitin carboxyl-terminal hydrolase 48 [OS=Homo sapiens]",22,15,29,15,1035,119,6.05,61.63,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","USP48","ENSG00000090686","","Ub-specific processing proteases","",1299,1348.2,1374.5,1417,1478,1527.5,0.9093725268513283,-0.13705667555755366,0.026361072103654997,1.5790369309811718,0.13685322538918765,0.8637449625781598,1504]
["High","Q86V21-1","acetoacetyl-CoA synthetase [OS=Homo sapiens]",19,14,38,14,672,75.1,6.24,75.73,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol","other molecular function","AACS","ENSG00000081760","","Synthesis of Ketone Bodies","Valine, leucine and isoleucine degradation; Butanoate metabolism; Metabolic pathways",1572.7,1591.3,1607.6,1380.7,1572.8,1473.1,1.0779379207518185,0.10827409460025272,0.11096242544336248,0.9548240589178633,0.3005184245098072,0.5221288966474357,2883]
["Medium","Q86VI4-1","Lysosomal-associated transmembrane protein 4B [OS=Homo sapiens]",2,1,5,1,370,41.1,8.97,1.63,"","","","","","","","",44.6,68.2,63.6,76,61.6,70.6,0.8472622478386169,-0.23911950774189616,0.27337484524874966,0.5632414497984148,0.5091867346617933,0.29312291911544963,4192]
["High","Q86VP3-1","Phosphofurin acidic cluster sorting protein 2 [OS=Homo sapiens]",3,2,3,2,889,97.6,6.6,3.91,"cell organization and biogenesis;other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","PACS2","ENSG00000179364","","","",151.7,169.2,178.9,153.2,171.2,157.5,1.0371446358165595,0.05261710034671463,0.5691968157351299,0.24473753816001292,0.7546763011139233,0.12223928782104622,5889]
["High","Q86W42","THO complex subunit 6 homolog [OS=Homo sapiens]",34,8,18,8,341,37.5,7.43,38.82,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity","THOC6","ENSG00000131652","","mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","Nucleocytoplasmic transport",582,572.5,568.3,550.4,573.4,574,1.0147249381552599,0.02108870855433575,0.39542079060674235,0.4029404998973904,0.6252421087601142,0.2039517808346685,4938]
["High","Q86WA8","Lon protease homolog 2, peroxisomal [OS=Homo sapiens]",4,3,5,3,852,94.6,7.3,4.92,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","LONP2","ENSG00000102910","IL-18 signaling pathway","Peroxisomal protein import; Association of TriC/CCT with target proteins during biosynthesis","",210.6,198.5,227.8,193.3,181.2,184.4,1.1395598497047776,0.1884766969637406,0.0481191039206568,1.3176824687373796,0.1898504110219749,0.7215884582851405,1979]
["High","Q86WP2-1","Vasculin [OS=Homo sapiens]",2,1,1,1,473,53.3,7.05,2.89,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","GPBP1","ENSG00000062194; ENSGGOG00000008390","","","",66.9,66.8,59,110.9,60.9,85.7,0.7483495145631068,-0.418215860662222,0.21487793530202556,0.6678081776614222,0.44350169675871415,0.35310471429553086,3783]
["High","Q86X10-1","Ral GTPase-activating protein subunit beta [OS=Homo sapiens]",12,12,19,12,1494,166.7,6.79,32.52,"other biological processes","","enzyme regulator activity;other molecular function","RALGAPB","ENSG00000170471","","Translocation of SLC2A4 (GLUT4) to the plasma membrane","",397.7,381.7,398.6,370.4,327.4,349.8,1.124474990454372,0.16925157436722701,0.03284664914502926,1.4835089284497127,0.15329745159855854,0.8144650647534719,1673]
["High","Q86X76","Deaminated glutathione amidase [OS=Homo sapiens]",37,9,18,9,327,35.9,7.74,42,"other metabolic processes","mitochondrion;other cell component","other molecular function","NIT1","ENSG00000158793","","","",1006,1041.4,1034.3,983.4,1049.6,1021.3,1.00897095897587,0.01288465021785726,0.6995288311696264,0.15519438130104532,0.8387470997807805,0.07636896852355474,6512]
["High","Q86XP3-1","ATP-dependent RNA helicase DDX42 [OS=Homo sapiens]",43,29,100,29,938,102.9,7.02,237.53,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX42","ENSG00000198231","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",3574.9,3639.4,3632.9,3631.7,3675.6,3742.4,0.9816737105984779,-0.02668451466980079,0.15163430457479485,0.8192025361566464,0.3648569029645603,0.437877432634399,3245]
["High","Q86Y37","CDK2-associated and cullin domain-containing protein 1 [OS=Homo sapiens]",20,6,10,6,369,41,5.19,30.34,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","","other molecular function","CACUL1","ENSG00000151893","","","",243.2,227.7,238.2,237.3,232.2,268.4,0.9609703211817319,-0.05743621971052223,0.475355545338614,0.32298143539046925,0.688221045429983,0.16227205101999623,5393]
["High","Q86Y91","Kinesin-like protein KIF18B [OS=Homo sapiens]",2,2,2,2,864,94.2,8.79,4.48,"","","","","","","","",151.3,180.5,164.7,182.2,169.1,175.3,0.9428408659323967,-0.08491380363032634,0.33897766138648655,0.46982892084187555,0.5763801350404371,0.23929099557315725,4592]
["Low","Q86YF9","Zinc finger protein DZIP1 [OS=Homo sapiens]",1,1,1,1,867,98.6,6.15,0,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DZIP1","ENSG00000134874","","Hedgehog 'on' state","",54.2,69.9,66.5,64.3,56.6,67.4,1.0122145512480085,0.017515119295713682,0.9003482869577721,0.04558945740080042,0.9526926988164094,0.021047163087116218,7379]
["High","Q86YS3","rab11 family-interacting protein 4 [OS=Homo sapiens]",3,2,2,1,637,71.9,4.87,2.45,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB11FIP4","ENSG00000131242","","","Endocytosis",15.2,18.1,23.7,13.4,20.9,13.9,1.1825726141078838,0.24192877282214242,0.4462800764145015,0.35039250123113336,0.6649913810390129,0.17718398355622464,5240]
["High","Q86YZ3","Hornerin [OS=Homo sapiens]",7,5,10,5,2850,282.2,10.04,25.5,"cell organization and biogenesis;developmental processes","non-structural extracellular;plasma membrane;other cytoplasmic organelle;other cell component","other molecular function","HRNR","ENSG00000197915","","Neutrophil degranulation","",484.2,221.3,312.7,404.9,300.6,498.3,0.8458215650440274,-0.24157475113750876,0.5540209456844991,0.2564738157350368,0.7436471624384681,0.12863307487476927,5817]
["High","Q8IUD2-1","ELKS/Rab6-interacting/CAST family member 1 [OS=Homo sapiens]",41,43,115,37,1116,128,5.97,231.63,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","ERC1","ENSG00000082805","","","NF-kappa B signaling pathway",4026.3,4777.2,4807.3,4746.3,4404.1,4335.1,1.0092914611990655,0.013342853241669051,0.890710580155178,0.050263388960006976,0.9494427590241133,0.02253121332751862,7325]
["Low","Q8IUM7","Neuronal pas domain-containing protein 4 [OS=Homo sapiens]",2,1,1,1,802,87.1,4.64,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NPAS4","ENSG00000174576","Orexin receptor pathway","","",28.4,17.9,16.2,26.7,17.4,19.7,0.9796238244514106,-0.02970023421542006,0.9314135768317373,0.03085743582552202,0.967728171377539,0.014246616089813554,7515]
["High","Q8IV08","Phospholipase D3 [OS=Homo sapiens]",12,5,19,5,490,54.7,6.47,34.28,"DNA metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","PLD3","ENSG00000105223","","Role of phospholipids in phagocytosis; Synthesis of PG","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways",577.5,575.9,605.9,480.3,546.2,514.8,1.141439044962045,0.19085381893273903,0.027308476378822957,1.563702529766106,0.13954488453262412,0.8552860793471417,1528]
["High","Q8IVD9","NudC domain-containing protein 3 [OS=Homo sapiens]",56,15,49,15,361,40.8,5.25,78.44,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","other molecular function","NUDCD3","ENSG00000015676","","","",1238.3,1220.2,1215.6,1055.4,1010.5,1009.6,1.194635018696147,0.25656991766635084,2.7662686952923207E-4,3.558105637959451,0.017418569332937454,1.7589875184630503,124]
["High","Q8IVL5","Prolyl 3-hydroxylase 2 [OS=Homo sapiens]",8,5,9,4,708,80.9,5.71,16.09,"protein metabolism;other metabolic processes;other biological processes","extracellular matrix;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","P3H2","ENSG00000090530","Type I collagen synthesis in the context of osteogenesis imperfecta","Collagen biosynthesis and modifying enzymes","",123.2,109.7,121.7,123.7,137,138.5,0.8882765531062125,-0.17091918443857185,0.07939595302031122,1.1002016339172396,0.25189906590109307,0.5987734429614066,2461]
["Medium","Q8IVV7","Glucose-induced degradation protein 4 homolog [OS=Homo sapiens]",4,1,1,1,300,33.5,9.16,2.55,"protein metabolism;other metabolic processes","other cell component","other molecular function","GID4","ENSG00000141034","Ciliary landscape","","",30,29.8,29.3,29.1,39.1,41.4,0.8129562043795621,-0.29875046143860473,0.14502420785430675,0.8385594980406308,0.35664535903194555,0.4477634230099899,3175]
["Medium","Q8IWB1","Inositol 1,4,5-trisphosphate receptor-interacting protein [OS=Homo sapiens]",1,1,1,1,547,62,5.88,2.41,"other biological processes","plasma membrane;other membranes;nucleus","enzyme regulator activity","ITPRIP","ENSG00000148841","","","",67.4,72.2,67,83.1,68.2,91.6,{"$f":"AVERAGE(T4482:V4482)/AVERAGE(W4482:Y4482)","v":0.8505557842733636},{"$f":"LOG(Z4482,2)","v":-0.23352223577080528},{"$f":"TTEST(T4482:V4482,W4482:Y4482,2,2)","v":0.16077625767930334},{"$f":"-LOG10(AB4482)","v":0.7937780844443387},{"$f":"AB4482*7808/AF4482","v":0.3765270005878826},{"$f":"-LOG10(AD4482)","v":0.4242038752776899},3334]
["Medium","Q8IWE2","Protein Noxp20 [OS=Homo sapiens]",4,1,1,1,563,60.7,4.68,0,"","cytosol;ER/Golgi;nucleus","","FAM114A1","ENSG00000197712","","","",22.6,23.9,30.8,26.3,33.9,29.3,0.8636871508379889,-0.21141926822677135,0.2940578348043055,0.5315672448729041,0.5318516502552739,0.2742094888705362,4317]
["High","Q8IWR0","Zinc finger CCCH domain-containing protein 7A [OS=Homo sapiens]",19,17,27,17,971,110.5,7.3,67.19,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZC3H7A","ENSG00000122299","","","",1259,1306.6,1239.7,1347.5,1298.3,1384.9,0.9440791921998659,-0.08302021262856693,0.07869875371529819,1.1040321451359105,0.2502972989853557,0.6015438369362626,2455]
["Low","Q8IWV2","Contactin-4 [OS=Homo sapiens]",1,1,2,1,1026,113.4,7.47,4.22,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","other molecular function","CNTN4","ENSG00000144619","","Post-translational modification: synthesis of GPI-anchored proteins","",184.1,175.2,172.4,180,196.6,173.2,0.967078937795562,-0.04829444043011232,0.48205482179420883,0.3169035687137835,0.6934200531630771,0.15900360304284758,5428]
["High","Q8IWZ6-1","Bardet-Biedl syndrome 7 protein [OS=Homo sapiens]",2,1,1,1,715,80.3,6.05,2.13,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BBS7","ENSG00000138686; ENSGGOG00000002169","Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","BBSome-mediated cargo-targeting to cilium","",36.1,37.2,40,35.3,27.4,37.7,1.1284860557768925,0.1743885918697438,0.26507248332210825,0.5766353532235965,0.5010133018104626,0.30015074354154736,4131]
["Medium","Q8IX21","SMC5-SMC6 complex localization factor protein 2 [OS=Homo sapiens]",1,1,1,1,1173,131.8,8.97,2.07,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","SLF2","ENSG00000119906","","","",68.3,74.3,78.5,73.5,93.5,64.2,0.9563148788927337,-0.06444237268445274,0.731193175707125,0.13596787056548446,0.8586488668854313,0.06618439885823972,6649]
["High","Q8IXI1","Mitochondrial Rho GTPase 2 [OS=Homo sapiens]",27,10,32,9,618,68.1,5.86,88.53,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion","other molecular function","RHOT2","ENSG00000140983","","RHOT2 GTPase cycle","Mitophagy",964.8,985.7,992.2,965.8,941.3,985.4,1.0173552290406223,0.024823511734763395,0.3327604064212885,0.47786835394292576,0.5701543237519027,0.24400757786673918,4557]
["Medium","Q8IXQ4","GPALPP motifs-containing protein 1 [OS=Homo sapiens]",2,1,2,1,340,38.1,5.41,2.83,"","","","GPALPP1","ENSG00000133114","","","",128.1,166,179.7,237,157.6,103.5,0.9512146155390484,-0.07215721243235601,0.8555414594746505,0.06775893973506003,0.9298535238833618,0.03158545873567258,7184]
["High","Q8IXU6-1","Solute carrier family 35 member f2 [OS=Homo sapiens]",10,2,5,2,374,41.2,6.21,10.53,"transport","other membranes","transporter activity","SLC35F2","ENSG00000110660","","","",181.6,215.3,189.9,197.6,187.2,176.1,1.0461757889106793,0.06512528799160498,0.5078810275291534,0.2942380104304993,0.7124568923729123,0.14724140776988803,5566]
["Medium","Q8IY26","Phospholipid phosphatase 6 [OS=Homo sapiens]",3,1,2,1,295,32.2,9.99,1.67,"other metabolic processes","plasma membrane;other membranes","other molecular function","PLPP6","ENSG00000205808","","Cholesterol biosynthesis","",24.5,29.7,30.5,31.4,28.7,31.1,0.9287280701754388,-0.10667185483254275,0.3534590743549199,0.4516608642171957,0.5897026608041057,0.22936691263268436,4680]
["High","Q8IY67-2","Isoform 2 of Ribonucleoprotein PTB-binding 1 [OS=Homo sapiens]",24,11,49,11,739,77.8,8.84,96.33,"","","","RAVER1","","","","",1528.9,1547.3,1600.5,1538,1517.6,1585.7,1.0076271734212396,0.010961933925020241,0.7092486834686851,0.14920146168341922,0.8449517425272343,0.0731680940711408,6554]
["High","Q8IYB7","DIS3-like exonuclease 2 [OS=Homo sapiens]",20,15,30,15,885,99.2,6.1,63.11,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","other cell component","nucleic acid binding activity;other molecular function","DIS3L2","ENSG00000144535","","","",1664.3,1718.6,1729.6,1630.2,1574,1626.4,1.0583571398998055,0.08182654334862739,0.025744773587760696,1.5893109232198712,0.1352726730640885,0.8687899279857922,1486]
["High","Q8IYS1","Peptidase M20 domain-containing protein 2 [OS=Homo sapiens]",6,2,2,2,436,47.7,5.85,0,"protein metabolism;other biological processes","nucleus","other molecular function","PM20D2","ENSG00000146281","","","",32.9,42.1,43.7,37.3,43.1,43.6,0.957258064516129,-0.06302018563233083,0.6760138665305059,0.1700443956324505,0.8243505028689974,0.08388809279798266,6403]
["High","Q8IYS2-1","Uncharacterized protein KIAA2013 [OS=Homo sapiens]",10,5,6,5,634,69.1,8.19,19.27,"","other membranes","","KIAA2013","ENSG00000116685","","","",191.7,189,190.9,172.1,161.6,162.7,1.1514907332796132,0.20350280096545975,1.8578348679312963E-3,2.7309928905217817,0.038375594309014716,1.4159448857003718,378]
["High","Q8IZ40","REST corepressor 2 [OS=Homo sapiens]",37,15,40,15,523,58,9.01,101.75,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","RCOR2","ENSG00000167771","","","",1315.7,1410.5,1394.3,1526.5,1500.2,1435.3,0.9234648139847602,-0.11487110244712821,0.046239248621284576,1.3349892317302876,0.18571813438013887,0.7311456876619079,1944]
["Medium","Q8IZE3","Protein-associating with the carboxyl-terminal domain of ezrin [OS=Homo sapiens]",1,1,1,1,742,82.8,5.05,2.05,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","SCYL3","ENSG00000000457","","","",132.3,133.2,135.5,124.2,128.2,132.2,1.0426417056682267,0.06024347400238536,0.09387810751580132,1.027435673906517,0.27535697350990856,0.560103920386538,2662]
["High","Q8IZQ5","Selenoprotein H [OS=Homo sapiens]",34,4,10,4,122,13.4,9.74,17.95,"","ER/Golgi","","SELENOH","ENSG00000211450","Selenium micronutrient network","","",440.8,363.6,364.4,422.3,346.6,368.4,1.0276971775257189,0.039415220911698114,0.7733969479487988,0.11159754611297994,0.881430939948069,0.05481170897372792,6851]
["High","Q8IZT6-1","Abnormal spindle-like microcephaly-associated protein [OS=Homo sapiens]",3,9,12,9,3477,409.5,10.45,16.43,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","ASPM","ENSG00000066279","","","",330.1,375.7,347,274.1,273.4,294.6,1.2502078137988364,0.32216792450156106,0.009467977649543713,2.0237427759532727,0.08061719682403196,1.0935723069646586,917]
["Medium","Q8N0Z8","tRNA pseudouridine synthase-like 1 [OS=Homo sapiens]",4,1,1,1,303,33.2,9.85,2.27,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","PUSL1","ENSG00000169972","","","",88.2,73.3,73.8,92.4,78.3,77.2,0.9491730536506657,-0.07525695086242448,0.5763867489828614,0.23928601208735742,0.7589254192340947,0.1198009007929846,5930]
["Medium","Q8N118","Cytochrome P450 4X1 [OS=Homo sapiens]",1,1,1,1,509,58.8,8.48,0,"","other membranes;ER/Golgi","other molecular function","CYP4X1","ENSG00000186377","Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II","","Serotonergic synapse",25.8,19.4,17.6,25.4,23.9,28.8,0.8040973111395647,-0.31455798925035217,0.1512514608542368,0.8203004220449478,0.36416016230338605,0.4387075660592852,3243]
["High","Q8N1G1","RNA exonuclease 1 homolog [OS=Homo sapiens]",6,6,6,6,1221,131.4,8.95,10.33,"other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","REXO1","ENSG00000079313","","","Ribosome biogenesis in eukaryotes",304.7,337.6,346.5,321.6,303.7,325.8,1.0396383135317002,0.056081707183291,0.4322513942081743,0.36426359725371543,0.6530609299491922,0.18504629758210767,5168]
["High","Q8N257","Histone H2B type 3-B [OS=Homo sapiens]",58,9,328,1,126,13.9,10.32,686.55,"cell organization and biogenesis","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","H2BU1","ENSG00000196890; ENSG00000285449","","Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Assembly of the ORC complex at the origin of replication; HATs acetylate histones; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Amyloid fiber formation; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Meiotic synapsis; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; HCMV Early Events; HCMV Late Events; HDACs deacetylate histones","Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis; Systemic lupus erythematosus",896.6,794.3,704,789.6,788.5,748.9,1.0291792006875806,0.041494206171821556,0.712639729497238,0.14712996949489843,0.8470529773046787,0.0720894267040213,6569]
["High","Q8N2F6-1","Armadillo repeat-containing protein 10 [OS=Homo sapiens]",17,4,6,4,343,37.5,6.61,13.58,"other biological processes","other membranes;mitochondrion;ER/Golgi","other molecular function","ARMC10","ENSG00000170632","","","",290.8,318.7,299.8,278.3,306.4,278.9,1.0529180176007409,0.07439310948297967,0.2862360951516292,0.5432756014052221,0.5231581064943635,0.2813670407670867,4272]
["High","Q8N339","Metallothionein-1M [OS=Homo sapiens]",36,2,12,1,61,6.1,7.69,19.87,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1M","ENSG00000205364","Zinc homeostasis","Metallothioneins bind metals","Mineral absorption",16,8.9,16.1,10.7,12.8,16.8,1.0173697270471465,0.024844070977478747,0.9413560553382885,0.026246079419633757,0.9731375718365359,0.011825759458165894,7553]
["High","Q8N3P4-1","Vacuolar protein sorting-associated protein 8 homolog [OS=Homo sapiens]",4,4,5,3,1428,161.7,5.64,6.06,"cell organization and biogenesis;transport","other cytoplasmic organelle","other molecular function","VPS8","ENSG00000156931","","","",18.5,14.2,17.6,17,15.7,17.2,1.0080160320641283,0.011518584468266568,0.9282590110308279,0.03233082618801953,0.9656070287941253,0.015199581606447686,7506]
["High","Q8N3X1","Formin-binding protein 4 [OS=Homo sapiens]",13,10,17,10,1017,110.2,4.74,30.6,"","nucleus","","FNBP4","ENSG00000109920; ENSG00000285182","","","",589,566.7,593.4,678.2,642.6,689.9,0.8698960560998655,-0.20108507129176756,6.0839491691801785E-3,2.2158144230931973,0.06525202625406433,1.1854059977475992,728]
["High","Q8N488","RING1 and YY1-binding protein [OS=Homo sapiens]",41,8,28,8,228,24.8,9.63,46.92,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RYBP","ENSG00000163602","","Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",646.1,561.5,648,602.2,531.6,574.6,1.0861624912198546,0.119239948207694,0.2352208342152526,0.6285242141265338,0.4669728638577911,0.33070835587764513,3933]
["High","Q8N4C6","ninein [OS=Homo sapiens]",3,6,8,5,2090,243.1,5.03,7.68,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","NIN","ENSG00000100503","","","",95.8,92,99.8,97.9,89,88,1.0461986176791562,0.06515676892634481,0.3353935750864955,0.4744452611431935,0.5725301780225965,0.24220161675528784,4574]
["High","Q8N4V1","Membrane magnesium transporter 1 [OS=Homo sapiens]",25,2,6,2,131,14.7,9.16,13.27,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity","MMGT1","ENSG00000169446","","Miscellaneous transport and binding events","",407.6,428.9,428.3,371.6,479.1,434,0.9845100023351754,-0.022522231324219842,0.8456380798204788,0.07281546860088657,0.9241066658136177,0.034277897069240205,7145]
["High","Q8N5A5-1","Zinc finger CCCH-type with G patch domain-containing protein [OS=Homo sapiens]",24,8,18,8,531,57.3,5.43,53.91,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZGPAT","ENSG00000197114","","","",813.8,806.3,779.8,710.7,775.6,706.9,1.0942458508115993,0.12993691354069928,0.04856514141411787,1.313675342328545,0.19122371364671323,0.7184582518752123,1983]
["High","Q8N5D0-1","WD and tetratricopeptide repeats protein 1 [OS=Homo sapiens]",4,2,2,2,677,75.9,7.27,4.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","WDTC1","ENSCATG00000044454; ENSCSAG00000000989; ENSG00000142784; ENSMFAG00000040733; ENSMNEG00000041566; ENSPANG00000008666; ENSPPAG00000030849; ENSPPYG00000001668","","Neddylation","",74,69,73.1,56.3,67.2,78.1,1.071924603174603,0.10020343335959062,0.4970916320647598,0.3035635476207832,0.7051765013011709,0.15170216818960264,5504]
["High","Q8N5N7","39S ribosomal protein L50, mitochondrial [OS=Homo sapiens]",21,2,2,2,158,18.3,7.88,4.88,"","other membranes;mitochondrion;translational apparatus","","MRPL50","ENSG00000136897","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",39.4,34.5,27.6,34.9,25.9,20.6,1.246928746928747,0.3183790278062915,0.2823278207236385,0.5492463241505053,0.5185640141637661,0.28519762445899277,4251]
["High","Q8N653","Leucine-zipper-like transcriptional regulator 1 [OS=Homo sapiens]",1,1,1,1,840,94.7,6.57,2.7,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LZTR1","ENSG00000099949","22q11.2 copy number variation syndrome","","",29.9,26.1,33.2,28.8,26.1,33.9,1.0045045045045045,6.4840335701987035E-3,0.9674617085150503,0.014366215052938293,0.9848684511193628,0.006621774343283847,7670]
["High","Q8N6G5-1","chondroitin sulfate N-acetylgalactosaminyltransferase 2 [OS=Homo sapiens]",4,2,2,2,542,62.5,5.73,4.97,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CSGALNACT2","ENSG00000169826; ENSPPAG00000040591; ENSPTRG00000002443","","Chondroitin sulfate biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",70.5,77.7,80.8,59.1,65,70.9,1.1743589743589742,0.23187347434733305,0.06832918134036577,1.1653937825773506,0.22986395859783537,0.6385291183746328,2321]
["High","Q8N720-1","zinc finger protein 655 [OS=Homo sapiens]",13,6,6,6,491,57.4,7.14,15.03,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF655","ENSG00000197343; ENSPPAG00000041610; ENSPTRG00000048790","Retinoblastoma gene in cancer","Generic Transcription Pathway","",342.6,308.5,335.9,428.1,373.7,403.3,0.8190191685337317,-0.2880308774228628,0.018259164316163937,1.7385191030987532,0.11261260267030648,0.9484130041214542,1266]
["High","Q8N8A6","ATP-dependent RNA helicase DDX51 [OS=Homo sapiens]",22,9,22,9,666,72.4,8.16,67.05,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DDX51","ENSG00000185163; ENSG00000288503","","","",518.7,496.5,491,477.6,513.7,495.3,1.0131844477330822,0.018896837126967877,0.65202796870044,0.18573377483288286,0.8093854339607369,0.0918446156195164,6290]
["Low","Q8N8K9","Uncharacterized protein KIAA1958 [OS=Homo sapiens]",1,1,1,1,716,79.2,6.83,2.28,"","","","KIAA1958","ENSG00000165185","","","",70.9,71.3,70.7,63.5,56.4,57,1.2035048049745616,0.2672419017618352,0.006242133208949568,2.204666967600445,0.06640132983035181,1.1778232228578802,734]
["High","Q8N983","39S ribosomal protein L43, mitochondrial [OS=Homo sapiens]",10,2,5,2,215,23.4,8.65,3.24,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL43","ENSG00000055950","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",147.5,140.6,138,156.8,149.8,133.1,0.9690698203320444,-0.04532748103442821,0.5820091981803086,0.2350701516260827,0.7623432007032125,0.11784946879692487,5961]
["High","Q8N9N8","probable RNA-binding protein EIF1AD [OS=Homo sapiens]",27,4,8,4,165,19,5.21,14.52,"protein metabolism;other metabolic processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity","EIF1AD","ENSG00000175376","","","",136.1,139.6,140.6,172,141.2,133.1,0.9327806408245575,-0.10039024811163687,0.44899971596449795,0.3477539337296172,0.6673881176948029,0.1756215298740904,5253]
["Medium","Q8N9V7","Testis- and ovary-specific PAZ domain-containing protein 1 [OS=Homo sapiens]",1,1,6,1,1692,190.8,7.87,1.81,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol","","TOPAZ1","ENSG00000173769","","","",178.3,232.1,241.2,217.6,333.9,242.4,0.8207582818994834,-0.28497069243448386,0.3059730258324673,0.5143168586441574,0.5428396695523529,0.26532842254846717,4401]
["High","Q8NB49-1","Phospholipid-transporting ATPase IG [OS=Homo sapiens]",18,14,19,14,1132,129.4,6.67,40.15,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","ATP11C","ENSG00000101974","Complement system in neuronal development and plasticity","Ion transport by P-type ATPases","",646.4,642.8,646,642.1,697.6,686.1,0.9552769276335272,-0.06600907460940417,0.14939858256911975,0.8256535229043547,0.3627189467349773,0.44042975832213294,3216]
["High","Q8NB90-1","Spermatogenesis-associated protein 5 [OS=Homo sapiens]",19,11,21,10,893,97.8,5.66,36.87,"developmental processes;other biological processes","cytoskeleton;mitochondrion;other cell component","other molecular function","SPATA5","ENSG00000145375","","","Ribosome biogenesis in eukaryotes",648.3,644,604.4,614.9,598.4,608.2,1.0412846555037056,0.05836451142883851,0.1649199722918344,0.7827267468363864,0.3805245696378968,0.41961729654473695,3384]
["High","Q8NBJ7-1","Sulfatase-modifying factor 2 [OS=Homo sapiens]",25,7,25,7,301,33.8,8,50.27,"","ER/Golgi","other molecular function","SUMF2","ENSG00000129103","","Glycosphingolipid metabolism; The activation of arylsulfatases","",999.4,958.9,963.3,961.7,921.2,888,1.0543866613735609,0.07640402461268345,0.11356224855195317,0.9447660169559928,0.3037663709125215,0.5174603072853717,2919]
["High","Q8NBN3-1","Transmembrane protein 87A [OS=Homo sapiens]",14,5,10,5,555,63.4,6.74,24.09,"transport","other membranes;cytosol;ER/Golgi","","TMEM87A","ENSG00000103978","","RHOA GTPase cycle","",207.5,212.6,217.6,228.6,225.7,230.9,0.9306771745475776,-0.10364727022434375,0.008486649543882206,2.071263731639847,0.0775014732615582,1.1106900417093841,855]
["High","Q8NBT2","kinetochore protein SPC24 [OS=Homo sapiens]",49,8,16,8,197,22.5,4.7,36.98,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","","SPC24","ENSG00000161888","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",553.7,530.6,548.2,590.9,533.3,533.5,0.984798214393437,-0.022099948913965373,0.7015332460150452,0.1539517427129575,0.840376125327627,0.07552629418344751,6518]
["High","Q8NC54","Keratinocyte-associated transmembrane protein 2 [OS=Homo sapiens]",5,1,1,1,265,29.2,5.08,2.85,"","other membranes","","KCT2","ENSG00000113583","","","",27.7,28.2,29.7,31.9,30.9,37.9,0.8500496524329693,-0.23438098160563767,0.09057717972462233,1.0429812059438803,0.2705534121231259,0.5677469845297705,2614]
["High","Q8NC96","adaptin ear-binding coat-associated protein 1 [OS=Homo sapiens]",27,6,17,6,275,29.7,6.8,34.83,"transport","plasma membrane;other membranes;cytosol","","NECAP1","ENSG00000089818","","Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",828.3,781.1,734.7,911.2,894.2,878.3,0.8734582852032643,-0.19518929062047924,0.01678538911938236,1.7750685864718667,0.10777986697708672,0.9674623567499475,1216]
["High","Q8NCH0","Carbohydrate sulfotransferase 14 [OS=Homo sapiens]",12,4,7,4,376,43,9.48,6.95,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST14","ENSG00000169105","Proteoglycan biosynthesis; Metapathway biotransformation Phase I and II","Dermatan sulfate biosynthesis; Defective CHST14 causes EDS, musculocontractural type","Glycosaminoglycan biosynthesis",45.6,46.9,44.7,48,45.2,47,0.978601997146933,-0.03120586783781083,0.390194466073641,0.4087188942719048,0.619865389848014,0.20770261178142382,4915]
["High","Q8ND30","Liprin-beta-2 [OS=Homo sapiens]",13,8,17,6,876,98.5,6.27,36.09,"cell organization and biogenesis","cytosol;other cell component","other molecular function","PPFIBP2","ENSG00000166387","Ectoderm differentiation","Receptor-type tyrosine-protein phosphatases","",98.3,87.8,103.3,106,89.2,94.8,0.9979310344827584,-2.9879783705724695E-3,0.9777058284811762,9.791795810726046E-3,0.9892350795362217,0.00470049140204437,7717]
["High","Q8ND76","cyclin-Y [OS=Homo sapiens]",7,2,3,1,341,39.3,7.2,7.6,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","enzyme regulator activity;other molecular function","CCNY","ENSG00000108100","","","",83.5,97.1,88.1,67.6,67.7,71.2,1.3012106537530266,0.3798545397063583,0.0076120520443772,2.1184982510591417,0.07355804747833809,1.1333698071750924,808]
["High","Q8NDX6","Zinc finger protein 740 [OS=Homo sapiens]",14,3,3,3,193,21.8,9.19,4.23,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF740","ENSG00000139651","","Generic Transcription Pathway","",188,177.7,176.3,208,217.9,205.1,0.8589540412044373,-0.2193471536286776,0.005172946481262167,2.286262014730827,0.06064619538392642,1.217196439242493,666]
["High","Q8NE62","Choline dehydrogenase, mitochondrial [OS=Homo sapiens]",5,4,6,4,594,65.3,8.28,8.09,"other metabolic processes","other membranes;mitochondrion","other molecular function","CHDH","ENSG00000016391","Methionine de novo and salvage pathway; One-carbon metabolism and related pathways","Choline catabolism","Glycine, serine and threonine metabolism; Metabolic pathways",300.2,332.7,304.9,344.8,368.3,343.6,0.887479890224283,-0.1722136656389039,0.037571898143188405,1.4251368636992197,0.16334152600334917,0.7869033913718698,1796]
["Medium","Q8NEE8","Tetratricopeptide repeat protein 16 [OS=Homo sapiens]",1,1,2,1,873,98.2,9.01,0,"","","","TTC16","ENSG00000167094","","","",103.3,105.3,108.9,114.6,99.5,97.3,1.0195889531149647,0.027987647467853545,0.7383927549764262,0.1317125732080324,0.8623049103882644,0.06433914080594672,6686]
["High","Q8NEN9","PDZ domain-containing protein 8 [OS=Homo sapiens]",9,7,10,7,1154,128.5,6.09,18.93,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PDZD8","ENSG00000165650","","","",196.2,203.6,213,171.7,191.7,175.9,1.1362877804561469,0.18432826341439704,0.03469415005647627,1.4597437474676525,0.15703879631360387,0.80399304221831,1725]
["High","Q8NEY1","neuron navigator 1 [OS=Homo sapiens]",17,24,41,24,1877,202.3,8.07,87.32,"cell organization and biogenesis;developmental processes","cytoskeleton;other cell component","","NAV1","ENSG00000134369","","","",1443.2,1519,1507.2,2029.8,1783.8,1879.4,0.7850693834533637,-0.3491079316593555,5.649216609872801E-3,2.2480117726403885,0.06292308600554469,1.2011899859484116,701]
["High","Q8NF99-1","Zinc finger protein 397 [OS=Homo sapiens]",11,4,7,2,534,61.1,7.27,9.32,"other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF397","ENSG00000186812","","","",57.2,55.2,52.2,49.7,48.6,51.5,1.0987983978638185,0.13592671196287473,0.04260647229875904,1.3705244227252984,0.17723566100623897,0.7514488906880092,1877]
["High","Q8NFH3","Nucleoporin Nup43 [OS=Homo sapiens]",20,5,11,5,380,42.1,5.63,29.01,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;nucleus;other cell component","","NUP43","ENSG00000120253","","Separation of Sister Chromatids; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Transport of Ribonucleoproteins into the Host Nucleus; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transport of Mature mRNA derived from an Intron-Containing Transcript; tRNA processing in the nucleus; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis",247.6,266.6,260.7,264.5,251.8,237.5,1.0279915096842664,0.0398283491747998,0.5047979951345215,0.29688237861285893,0.7104294783724484,0.1484790263554708,5548]
["High","Q8NFP7","Diphosphoinositol polyphosphate phosphohydrolase 3-alpha [OS=Homo sapiens]",27,4,6,1,164,18.5,5.68,15.96,"other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT10","ENSG00000122824","","Synthesis of pyrophosphates in the cytosol","",46.5,45.5,44.2,57.4,62.3,59.4,0.7604690117252931,-0.39503863397389005,8.0702367764716682E-4,3.093113723120981,0.027160521013228786,1.5660619033532452,232]
["High","Q8NFY9","Kelch repeat and BTB domain-containing protein 8 [OS=Homo sapiens]",5,3,4,3,601,68.8,6.29,7.76,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","","KBTBD8","ENSG00000163376","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",205.9,207.4,202.6,183.9,199.4,193,1.068714211348256,0.09587610844307466,0.048839268917069516,1.3112308457029722,0.191530392619025,0.7177623010717463,1991]
["High","Q8NG48-1","protein Lines homolog 1 [OS=Homo sapiens]",2,2,7,1,757,85.8,6.52,9.69,"other biological processes","","","LINS1","ENSG00000140471","","","",98.9,93.6,86.9,93.4,65.3,84.2,1.1502675998353233,0.2019695307735983,0.24650771648881303,0.6081694813520312,0.47926599859179586,0.3194233808303587,4016]
["High","Q8NHP6-1","motile sperm domain-containing protein 2 [OS=Homo sapiens]",20,7,12,7,518,59.7,5.96,23.2,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","MOSPD2","ENSG00000130150","","Neutrophil degranulation; RHOD GTPase cycle","",513.2,472.1,491.7,507.4,459.3,461.2,1.034386161495903,0.048774879337774704,0.4528516816626726,0.3440440151676314,0.670560578498416,0.17356198184046012,5273]
["High","Q8NI36","WD repeat-containing protein 36 [OS=Homo sapiens]",15,13,37,13,951,105.3,7.53,67.35,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","WDR36","ENSG00000134987","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1501.4,1519.2,1571.2,1453,1615.3,1614,0.9806718920188797,-0.02815756693979257,0.6293572559381364,0.20110275640305947,0.7963087756222604,0.09891849815881051,6171]
["Medium","Q8TAD4-1","Zinc transporter 5 [OS=Homo sapiens]",1,1,1,1,765,84,7.31,2.25,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A5","ENSG00000145740","Zinc homeostasis","Insulin processing; Zinc efflux and compartmentalization by the SLC30 family","",60.5,58.6,44.1,50.5,69.4,57.8,0.9184018007878447,-0.12280262405718251,0.5572237061055717,0.253970415557777,0.7455110858931295,0.12754589412055556,5836]
["High","Q8TAD7","Overexpressed in colon carcinoma 1 protein [OS=Homo sapiens]",19,1,1,1,63,6.4,6.57,2.01,"","","","OCC1","ENSG00000235162","","","",17.9,14.8,14,15.8,15,13.5,1.054176072234763,0.07611585115464373,0.5898401912393773,0.2292656382969544,0.7674507937338872,0.11494946040441553,6001]
["High","Q8TB52","F-box only protein 30 [OS=Homo sapiens]",5,3,4,3,745,82.3,5.4,12.41,"protein metabolism;other metabolic processes","cytosol","other molecular function","FBXO30","ENSG00000118496","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",162.7,141,147.8,163.7,138,148.4,1.0031104199066874,0.004480422982669099,0.964437552913887,0.015725887566920085,0.9835852159288963,0.007188007677071836,7656]
["Medium","Q8TBC5","Zinc finger and SCAN domain-containing protein 18 [OS=Homo sapiens]",1,1,1,1,510,54.8,4.82,2.35,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZSCAN18","ENSG00000121413","","","",144.6,144.1,142.4,135.2,141.5,126.2,1.069992553983619,0.09760075702989444,0.10437063773508758,0.9814216628584813,0.29114896014132324,0.5358847566660083,2799]
["Medium","Q8TBF5-1","Phosphatidylinositol-glycan biosynthesis class X protein [OS=Homo sapiens]",7,1,1,1,258,28.8,6.33,0,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","","PIGX","ENSG00000163964","3q29 copy number variation syndrome","Synthesis of glycosylphosphatidylinositol (GPI)","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways",65.6,74.8,73,64.6,39,60.4,1.3012195121951218,0.37986436131897866,0.12188872999661451,0.9140364480038541,0.3188298840246453,0.4964409788106065,2985]
["High","Q8TC12","Retinol dehydrogenase 11 [OS=Homo sapiens]",17,5,11,5,318,35.4,8.82,21.05,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","RDH11","ENSG00000072042","","RA biosynthesis pathway; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision)","Retinol metabolism; Metabolic pathways; Biosynthesis of cofactors",563.1,542,543.4,470.2,571,534,1.0465337734890807,0.06561887065619591,0.4640970059032271,0.33339123339933074,0.6794804841725853,0.16782301242357195,5333]
["High","Q8TCA0-1","Leucine-rich repeat-containing protein 20 [OS=Homo sapiens]",6,1,1,1,184,20.5,6.55,3.47,"","","","LRRC20","ENSG00000172731; ENSPTRG00000002588","","","",32.2,35,31.2,25.8,32.7,22.4,1.2163164400494437,0.2825186129092623,0.14583051692439053,0.8361515847625225,0.35817699784386325,0.44590230801866004,3179]
["High","Q8TCG2","Phosphatidylinositol 4-kinase type 2-beta [OS=Homo sapiens]",17,8,10,7,481,54.7,5.97,18.49,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","kinase activity;other molecular function","PI4K2B","ENSG00000038210","","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane; Synthesis of PIPs at the early endosome membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",271.6,284.4,264.5,268.1,268.1,290.2,0.9928606001936108,-0.010336920463984517,0.8443363433058031,0.0734845167110676,0.92358898410363,0.034521255672073786,7138]
["High","Q8TCZ2","CD99 antigen-like protein 2 [OS=Homo sapiens]",8,2,3,2,262,28,5.14,6.32,"cell adhesion","plasma membrane;other membranes","","CD99L2","ENSG00000102181","","Cell surface interactions at the vascular wall","Cell adhesion molecules; Leukocyte transendothelial migration",169.1,173.9,154.7,185.2,174.1,209.7,0.8746924428822497,-0.1931522655169247,0.11861502476071928,0.9258602961539755,0.3137351332424445,0.5034368446463441,2952]
["Medium","Q8TD31-1","Coiled-coil alpha-helical rod protein 1 [OS=Homo sapiens]",1,1,1,1,782,88.6,5.95,1.83,"transport;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CCHCR1","ENSG00000204536; ENSG00000206355; ENSG00000206457; ENSG00000234114","","","",43.4,49.1,39.9,76.4,70.9,71.6,0.6048423937871173,-0.7253688323737285,8.2995849306767772E-4,3.080943626518401,0.02769365775159157,1.5576196792699086,234]
["High","Q8TD55","pleckstrin homology domain-containing family O member 2 [OS=Homo sapiens]",19,7,12,7,490,53.3,5.43,28.78,"","non-structural extracellular;other cell component","","PLEKHO2","ENSG00000241839","","Neutrophil degranulation","",492.6,482.5,426,524.8,384.4,415.1,1.0579929019104433,0.08132994842268101,0.6177066923336876,0.20921769342052687,0.7873088236600444,0.10385488123244542,6126]
["High","Q8TDJ6-1","DmX-like protein 2 [OS=Homo sapiens]",2,4,5,3,3036,339.4,6.38,7.05,"other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","DMXL2","ENSG00000104093","","","Lysosome",34.7,36.8,30.1,43.9,33,36.9,0.8927943760984182,-0.16360015553441626,0.33945813110248946,0.4692137841301123,0.576694753622332,0.2390539994877244,4596]
["High","Q8TDY2-1","RB1-inducible coiled-coil protein 1 [OS=Homo sapiens]",17,23,35,23,1594,183,5.41,54.38,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RB1CC1","ENSG00000023287","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Malignant pleural mesothelioma; Alzheimer's disease","Macroautophagy","Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",1369.9,1332.7,1349.8,1308.3,1293.6,1268.5,1.0470235634559737,0.0662939107487081,0.01857877159802097,1.7309830043271675,0.11386424539823214,0.9436126276678635,1274]
["High","Q8TE77","Protein phosphatase Slingshot homolog 3 [OS=Homo sapiens]",14,6,9,6,659,73,5.3,13.74,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SSH3","ENSG00000172830","Regulation of actin cytoskeleton","","Axon guidance; Regulation of actin cytoskeleton",276.9,287.2,283.1,322.9,317.1,280.7,0.9201694362984684,-0.12002855719530484,0.14467656836160425,0.8396018009837799,0.3561269375054874,0.44839517497071063,3172]
["High","Q8TEH3","DENN domain-containing protein 1A [OS=Homo sapiens]",16,11,18,11,1009,110.5,6.96,32.4,"transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DENND1A","ENSG00000119522","","RAB GEFs exchange GTP for GDP on RABs","",618.4,611.5,662.5,658.8,624.2,639,0.9845993756503644,-0.02239127014944609,0.62848556578567,0.20170469215721057,0.7961089061736717,0.09902751754495681,6164]
["High","Q8TEU7","Rap guanine nucleotide exchange factor 6 [OS=Homo sapiens]",6,6,7,5,1601,179.3,6.4,13.78,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","RAPGEF6","ENSG00000158987","","","Rap1 signaling pathway; Tight junction",113.3,115.2,96.3,125.3,116.8,117.8,0.9024729091414283,-0.1480444697395511,0.1500103720960755,0.8238787116885854,0.3625134587824691,0.44067586504759404,3231]
["High","Q8TF09","Dynein light chain roadblock-type 2 [OS=Homo sapiens]",13,1,2,1,96,10.8,7.5,4.85,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DYNLRB2","ENSG00000168589","Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome","Intraflagellar transport","Salmonella infection",96.1,94.5,84.9,112.1,92.8,84.3,0.952627939142462,-0.07001523349259775,0.6362824591600712,0.1963500490959962,0.7995000709883868,0.09718149335631647,6214]
["High","Q8TF46","DIS3-like exonuclease 1 [OS=Homo sapiens]",4,3,3,3,1054,120.7,6.54,4.64,"RNA metabolism OR transcription;other metabolic processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","DIS3L","ENSG00000166938","","","RNA degradation",101.3,100.4,105.7,108.8,104.1,119.6,0.9245112781954886,-0.11323717558514317,0.16105331504110484,0.7930303314512942,0.37672387173185934,0.4239768591358868,3338]
["Medium","Q8WTW4","GATOR complex protein NPRL2 [OS=Homo sapiens]",2,1,1,1,380,43.6,6.52,0,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;kinase activity","NPRL2","ENSG00000114388","22q11.2 copy number variation syndrome","Amino acids regulate mTORC1","mTOR signaling pathway",27.5,27.9,26.4,32.8,27.7,29.3,0.9109131403118039,-0.13461460179939827,0.16490653966729563,0.7827621212802613,0.38060604839557916,0.4195243144096065,3383]
["High","Q8WU90","Zinc finger CCCH domain-containing protein 15 [OS=Homo sapiens]",50,22,60,22,426,48.6,5.31,136.13,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","other molecular function","ZC3H15","ENSG00000065548","VEGFA-VEGFR2 signaling pathway","","",3183.5,3317.4,3248.2,3689.5,3288.6,3055.7,0.9716259044429826,-0.04152714082009455,0.642115346682824,0.19238695023610128,0.8039827817350048,0.09475325209426992,6236]
["High","Q8WUD6-1","Cholinephosphotransferase 1 [OS=Homo sapiens]",4,1,1,1,406,45.1,6.92,2.1,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","CHPT1","ENSG00000111666","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids","Synthesis of PC","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways; Choline metabolism in cancer",15.9,13.3,11.6,13.7,11.3,17.3,0.9645390070921988,-0.05208851114845389,0.8271683986423328,0.08240606583308176,0.9133829524253054,0.039347098418432556,7071]
["High","Q8WUI4","histone deacetylase 7 [OS=Homo sapiens]",4,3,4,3,952,102.9,7.58,9.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","HDAC7","ENSG00000061273","MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling pathway; Ethanol effects on histone modifications; Gastrin signaling pathway","Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway","Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis",135.4,118.8,128.8,135.7,137.9,141.2,0.9233365477338475,-0.1150715020009064,0.10538897766091054,0.9772048083963555,0.29242257909608727,0.5339890968364469,2814]
["High","Q8WUN7","Ubiquitin domain-containing protein 2 [OS=Homo sapiens]",12,2,2,2,234,26.2,5.67,5.68,"","other cell component","","UBTD2","ENSG00000168246","","","",41.1,49.8,43.9,48.2,46.4,44.3,0.9704823614110875,-0.04322610279953359,0.6511193586266514,0.1863393923205123,0.8087718663946697,0.09217396434343812,6286]
["High","Q8WUY8","N-acetyltransferase 14 [OS=Homo sapiens]",11,1,2,1,206,21.6,10.74,7.22,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus","nucleic acid binding activity;other molecular function","NAT14","ENSG00000090971","Metapathway biotransformation Phase I and II","","",16.5,13.5,10.1,14.7,17.3,16.1,0.8336798336798337,-0.26243465731512167,0.252400548696845,0.5979097053084382,0.48720481686649336,0.31228842659809386,4045]
["High","Q8WV74","Nucleoside diphosphate-linked moiety X motif 8 [OS=Homo sapiens]",6,1,1,1,236,25.4,8.41,4.51,"other metabolic processes","mitochondrion","other molecular function","NUDT8","ENSG00000167799","","","",39,33.7,43.4,37,39.9,46.3,0.9423701298701297,-0.08563428382933516,0.579110540751439,0.23723853013047821,0.7608438671020084,0.11870445573005231,5943]
["High","Q8WVD3-1","E3 ubiquitin-protein ligase RNF138 [OS=Homo sapiens]",8,2,2,2,245,28.2,6.93,2.4,"cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction","other cell component","nucleic acid binding activity;other molecular function","RNF138","ENSG00000134758; ENSGGOG00000027857; ENSPPYG00000009094; ENSPTRG00000009956","","Antigen processing: Ubiquitination & Proteasome degradation","",90.5,101.9,76.5,109.8,93.4,108.9,0.861582826017302,-0.21493860204633758,0.18760236109384473,0.726761700053035,0.4101930090788966,0.38701174558718143,3571]
["Medium","Q8WVL7","ankyrin repeat domain-containing protein 49 [OS=Homo sapiens]",5,1,1,1,239,27.3,5.15,2.54,"other biological processes","nucleus","","ANKRD49","ENSG00000168876","","","",23.7,25,21.8,22,20.6,28.8,0.9873949579831932,-0.01830081674294389,0.9168045826652089,0.037723224542000965,0.9600872024476865,0.017689319229290547,7456]
["High","Q8WVQ1","Soluble calcium-activated nucleotidase 1 [OS=Homo sapiens]",9,3,5,3,401,44.8,6.09,12.48,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","CANT1","ENSG00000171302","Proteoglycan biosynthesis","Neutrophil degranulation","Purine metabolism; Pyrimidine metabolism; Metabolic pathways",226.9,217.3,238,193.6,224.7,224.9,1.0606343283582091,0.0849273484344757,0.3394977766053808,0.4691630655990204,0.5765112309123126,0.2391922278736452,4598]
["Medium","Q8WW35","Tctex1 domain-containing protein 2 [OS=Homo sapiens]",13,1,1,1,142,16.1,4.93,0,"cell organization and biogenesis;transport;other biological processes","cytoskeleton;other cell component","other molecular function","DYNLT2B","ENSG00000213123","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 3q29 copy number variation syndrome","Intraflagellar transport","",31.9,27.7,23.6,31.5,36.2,29.7,0.8542094455852155,-0.22733824394125018,0.19932837066934572,0.7004308831948709,0.42384420429908803,0.3727937510654404,3672]
["High","Q8WWM7-1","ataxin-2-like protein [OS=Homo sapiens]",30,26,79,25,1075,113.3,8.59,155.2,"cell organization and biogenesis;other biological processes","other membranes;cytosol;nucleus;other cell component","","ATXN2L","ENSG00000168488","16p11.2 distal deletion syndrome","","Amyotrophic lateral sclerosis; Spinocerebellar ataxia; Pathways of neurodegeneration",3503.5,3692.5,3710.2,4245.8,3577,3617.5,0.9533141613419229,-0.06897636729971883,0.47558584202262033,0.3227710826130022,0.6884268176701186,0.16214222007123918,5394]
["High","Q8WX77","Insulin-like growth factor-binding protein-like 1 [OS=Homo sapiens]",3,1,4,1,278,29,7.93,5.24,"other biological processes","non-structural extracellular","other molecular function","IGFBPL1","ENSG00000137142","","","",215.2,217.9,214.8,246.3,226.6,220.3,0.9346508944027698,-0.0975004966924116,0.1282193663787923,0.8920463735985515,0.32997258163665466,0.4815221453906278,3034]
["High","Q8WXE1","ATR-interacting protein [OS=Homo sapiens]",8,3,17,3,791,85.8,6.32,5.94,"DNA metabolism;other metabolic processes;stress response;signal transduction","nucleus","other molecular function","ATRIP","ENSG00000164053","miRNA regulation of DNA damage response; ATR signaling; DNA damage response","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Fanconi Anemia Pathway; Activation of ATR in response to replication stress; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA)","Fanconi anemia pathway",500.5,514.8,511.7,509.2,423.9,495.2,1.069103129594623,0.0964010274067195,0.28636684761512043,0.5430772612636151,0.5232745954081115,0.28127034942217616,4273]
["High","Q8WXF7","Atlastin-1 [OS=Homo sapiens]",9,4,5,3,558,63.5,6.18,6.09,"cell organization and biogenesis;developmental processes","other membranes;ER/Golgi;other cell component","other molecular function","ATL1","ENSG00000198513","","","",130.4,102.4,99.1,113.4,91.3,109.3,1.0570063694267515,0.07998407029931044,0.6458501813279574,0.18986821415448918,0.8058162697041692,0.0937639683060283,6258]
["High","Q8WXW3","Progesterone-induced-blocking factor 1 [OS=Homo sapiens]",11,8,9,8,757,89.8,6.02,21.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding","PIBF1","ENSG00000083535","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies","","",349.6,339.8,319.8,416.7,382.2,409.1,0.835430463576159,-0.2594083432361407,0.008319339901496454,2.079911131462943,0.07678180372444954,1.114741689843331,846]
["High","Q8WY22","BRI3-binding protein [OS=Homo sapiens]",10,2,3,2,251,27.8,9.44,9.3,"","other membranes;mitochondrion","","BRI3BP","ENSG00000184992","","","",152.2,172.4,134.4,139.8,138.7,142.1,1.0912981455064192,0.12604530356939073,0.3101135962953411,0.5084791925933824,0.5465839638541813,0.2623431141578165,4430]
["High","Q8WYL5-1","Protein phosphatase Slingshot homolog 1 [OS=Homo sapiens]",3,2,2,2,1049,115.4,6.25,0,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SSH1","ENSG00000084112","Regulation of actin cytoskeleton","","Axon guidance; Regulation of actin cytoskeleton",30,29.9,41.3,40.7,37.2,36.7,0.8830715532286211,-0.1793977540625951,0.3253227155441406,0.48768561120001735,0.5625957393064562,0.24980356119090658,4515]
["High","Q8WZA9","Immunity-related GTPase family Q protein [OS=Homo sapiens]",29,10,21,10,623,62.7,4.88,52.89,"","","other molecular function","IRGQ","ENSG00000167378","","","",388.5,371.3,393.3,361.6,339.8,330.9,1.1170202460525036,0.15965533498401802,0.023536688212471867,1.6282546456656128,0.12978422426764147,0.8867780943607277,1416]
["High","Q92503-1","SEC14-like protein 1 [OS=Homo sapiens]",12,6,8,6,715,81.2,6.43,13.9,"stress response;transport;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding","SEC14L1","ENSG00000129657","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","",353.2,371.4,362.7,389.2,420.5,402.8,0.8967422680412371,-0.15723469396483966,0.01634607341083755,1.7865865549797983,0.10618148185675506,0.9739512179878838,1202]
["High","Q92530","proteasome inhibitor PI31 subunit [OS=Homo sapiens]",9,1,7,1,271,29.8,5.74,13.62,"protein metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMF1","ENSG00000125818","","Regulation of expression of SLITs and ROBOs; Neddylation; Ub-specific processing proteases; Separation of Sister Chromatids; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; ER-Phagosome pathway; Downstream TCR signaling; UCH proteinases; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome",28.6,30.4,32.2,24.4,24,19.5,1.3431516936671575,0.4256222499200098,0.014571894806726125,1.836483972553871,0.09989232190598558,1.000467891974336,1139]
["High","Q92542-1","Nicastrin [OS=Homo sapiens]",19,10,31,10,709,78.4,5.99,46.36,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","NCSTN","ENSG00000162736; ENSGGOG00000003518","Alzheimer's disease and miRNA effects; Notch signaling; Inclusion body myositis; Alzheimer's disease; Notch signaling pathway","Neutrophil degranulation; Amyloid fiber formation; Degradation of the extracellular matrix; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; Nuclear signaling by ERBB4; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3","Notch signaling pathway; Alzheimer disease",1138,1131.5,1127.9,1053.5,1139.7,1078.8,1.0383251833740832,0.05425833865787551,0.1798675701570076,0.7450471322156221,0.4002296915890326,0.3976906957723929,3509]
["High","Q92574-1","Hamartin [OS=Homo sapiens]",21,18,32,18,1164,129.7,6.47,43.57,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TSC1","ENSG00000165699","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Glioblastoma signaling pathways; Nanoparticle triggered autophagic cell death; Wnt signaling pathway; BDNF-TrkB signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; CAMKK2 pathway; Malignant pleural mesothelioma","TP53 Regulates Metabolic Genes; Macroautophagy; TBC/RABGAPs; Energy dependent regulation of mTOR by LKB1-AMPK; Inhibition of TSC complex formation by PKB","Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Cellular senescence; Thermogenesis; Insulin signaling pathway; Human cytomegalovirus infection; Human papillomavirus infection; Herpes simplex virus 1 infection; Choline metabolism in cancer",1157.7,1193.3,1208.5,1176.2,1158.6,1158.5,1.0189505625053674,0.027084056451180748,0.24390276198112787,0.6127832816609672,0.4759791965880146,0.32241202838132893,4001]
["High","Q92581-1","Sodium/hydrogen exchanger 6 [OS=Homo sapiens]",2,1,1,1,669,74.1,6.48,3.74,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","SLC9A6","ENSG00000198689","","Sodium/Proton exchangers; Defective SLC9A6 causes  X-linked, syndromic mental retardation,, Christianson type (MRXSCH)","Cardiac muscle contraction",59.2,55.7,61.1,52.6,55.2,47.4,1.1340206185567008,0.1814468713375316,0.0675494799053554,1.17037799046288,0.22802695162170988,0.6420138185748638,2313]
["High","Q92613","protein jade-3 [OS=Homo sapiens]",4,3,7,3,823,93.7,7.18,2.9,"protein metabolism;other metabolic processes","nucleus","other molecular function","JADE3","ENSG00000102221","","HATs acetylate histones","",94.5,113.1,106.5,104.6,113.3,110,0.9579139981701739,-0.06203195874109619,0.4864213899762411,0.3129873355766116,0.6968767363182552,0.15684403319461865,5450]
["High","Q92618","Zinc finger protein 516 [OS=Homo sapiens]",9,10,12,10,1163,124.2,8.72,24.97,"stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF516","ENSG00000101493","Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects","","Thermogenesis",607.9,643.2,630.9,642.1,618.4,656.4,0.9817935207887736,-0.02650844901936464,0.4856357337826524,0.3136893647382874,0.6962621757941517,0.15722719708359773,5446]
["High","Q92665","28S ribosomal protein S31, mitochondrial [OS=Homo sapiens]",26,8,14,8,395,45.3,9.29,34.3,"","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS31","ENSG00000102738","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",546.4,543.5,500.4,606.4,502.7,563.2,0.9509657358129524,-0.07253473452000682,0.4609796512695722,0.33631824497127644,0.6765656235174473,0.1696900726076892,5320]
["High","Q92729-1","Receptor-type tyrosine-protein phosphatase U [OS=Homo sapiens]",1,1,1,1,1446,162.3,6.92,2.6,"cell adhesion;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PTPRU","ENSG00000060656","EPO receptor signaling","Signaling by SCF-KIT","",40.8,44.9,43.6,42.7,47.5,47.2,0.9410480349344976,-0.0876597290078461,0.24200791245990172,0.616170434509249,0.47370212596814054,0.32449466616045314,3989]
["High","Q92738-1","USP6 N-terminal-like protein [OS=Homo sapiens]",4,2,2,2,828,94,9.07,7.22,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","USP6NL","ENSG00000148429","EGF/EGFR signaling pathway","Retrograde transport at the Trans-Golgi-Network","",114.7,115.8,116.1,101.5,120.4,117.2,{"$f":"AVERAGE(T5186:V5186)/AVERAGE(W5186:Y5186)","v":1.0221173695075199},{"$f":"LOG(Z5186,2)","v":0.031560870134738725},{"$f":"TTEST(T5186:V5186,W5186:Y5186,2,2)","v":0.6914022458196307},{"$f":"-LOG10(AB5186)","v":0.16026921411167838},{"$f":"AB5186*7808/AF5186","v":0.8342557155555056},{"$f":"-LOG10(AD5186)","v":0.07870080927525046},6471]
["High","Q92793-1","CREB-binding protein [OS=Homo sapiens]",10,18,33,12,2442,265.2,8.53,61.8,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CREBBP","ENSG00000005339","Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL-6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RORA activates gene expression; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; SUMOylation of transcription cofactors; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; Formation of the beta-catenin:TCF transactivating complex; Estrogen-dependent gene expression; HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production","cAMP signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Cell cycle; Wnt signaling pathway; Notch signaling pathway; TGF-beta signaling pathway; Adherens junction; JAK-STAT signaling pathway; Long-term potentiation; Melanogenesis; Thyroid hormone signaling pathway; Glucagon signaling pathway; Growth hormone synthesis, secretion and action; Huntington disease; Tuberculosis; Hepatitis B; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Renal cell carcinoma; Prostate cancer",1013.6,1097.9,1087.3,1195.9,1197.2,1255.1,0.8768159640370592,-0.18965402944996998,0.010416279133809382,1.9822873904647453,0.08384567781111718,1.0765193200723548,970]
["High","Q92802-1","NEDD4-binding protein 2-like 2 [OS=Homo sapiens]",4,3,3,3,583,67.4,6.39,2.14,"developmental processes;other biological processes","nucleus;other cell component","other molecular function","N4BP2L2","ENSG00000244754","","","",179.3,181,176.4,273.1,266,268.9,0.6642326732673268,-0.5902394048660925,3.2686477954798058E-6,5.485631873154795,0.008507200662368776,2.0702133232158224,3]
["High","Q92834","X-linked retinitis pigmentosa GTPase regulator [OS=Homo sapiens]",3,2,2,1,1020,113.3,4.86,2.16,"cell organization and biogenesis;transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity","RPGR","ENSG00000156313","Ciliary landscape","","",26.3,23.1,27,22.3,24,18.2,1.184496124031008,0.24427347772513242,0.1317384069761507,0.8802875924934899,0.33527166938389324,0.4746031431117979,3068]
["High","Q92882","osteoclast-stimulating factor 1 [OS=Homo sapiens]",21,3,6,3,214,23.8,5.68,13.39,"signal transduction;other biological processes","other cell component","other molecular function","OSTF1","ENSG00000134996","","Neutrophil degranulation","",204.9,188.2,166.7,145.3,131.7,140.7,1.3401963131434045,0.4224443434101223,0.015742934570006428,1.8029143095392623,0.10355588300135653,0.9848252238352181,1187]
["High","Q92888-1","Rho guanine nucleotide exchange factor 1 [OS=Homo sapiens]",18,13,24,13,912,102.4,5.66,48.85,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","ARHGEF1","ENSG00000076928","G protein signaling pathways; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway","G alpha (12/13) signalling events; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK","Vascular smooth muscle contraction; Platelet activation; Regulation of actin cytoskeleton; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis",819.7,804.7,776.5,884,874.6,878.6,0.9103973911724558,-0.1354316714124119,3.6961199495412797E-3,2.432253943139543,0.05247146284730602,1.2800768279751513,550]
["High","Q92922","SWI/SNF complex subunit SMARCC1 [OS=Homo sapiens]",47,52,215,42,1105,122.8,5.76,457.93,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","SMARCC1","ENSG00000173473","Tumor suppressor activity of SMARCB1; Thermogenesis","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Thermogenesis; Hepatocellular carcinoma",9890.7,10514.6,10726.6,10931.7,10419,10833.6,0.9673008268006451,-0.047963462848022,0.30159096410214825,0.5205816744049231,0.5389842636094241,0.26842391445585606,4369]
["High","Q92993-1","Histone acetyltransferase KAT5 [OS=Homo sapiens]",7,4,4,4,513,58.5,8.48,8.03,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","HTATIP; KAT5","ENSANAG00000035412; ENSCANG00000040731; ENSCCAG00000033565; ENSG00000172977; ENSGGOG00000003283; ENSMLEG00000035009; ENSMNEG00000035393; ENSPANG00000021813; ENSPPAG00000042045; ENSPPYG00000003052; ENSPTRG00000003890; ENSRBIG00000038205; ENSRROG00000042827; ENSSBOG00000020725","Androgen receptor signaling pathway; ATM signaling in development and disease ; Joubert syndrome; Gastrin signaling pathway; Androgen receptor signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex; Estrogen-dependent gene expression; DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; HDR through Single Strand Annealing (SSA); Sensing of DNA Double Strand Breaks","Spinocerebellar ataxia; Human T-cell leukemia virus 1 infection",94.1,105.3,92.5,117.4,109.6,105.9,0.8768398918594174,-0.18961465963799526,0.06026003856298235,1.2199705947389132,0.2158304500457643,0.6658872836848827,2180]
["High","Q92995","Ubiquitin carboxyl-terminal hydrolase 13 [OS=Homo sapiens]",22,14,33,13,863,97.3,5.53,55.16,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","USP13","ENSG00000058056","","Ub-specific processing proteases; Regulation of PTEN stability and activity","",741.9,725.9,719.7,784.4,796.4,836.4,0.9049726956809533,-0.14405383020525536,0.010909299097581693,1.962203151137682,0.08526507242634421,1.069228834705029,999]
["High","Q93073-1","Selenocysteine insertion sequence-binding protein 2-like [OS=Homo sapiens]",2,2,2,2,1101,121.7,6.04,5.06,"protein metabolism;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","KIAA0256; SECISBP2L","ENSG00000138593; ENSGGOG00000007289","Thyroid hormones production and peripheral downstream signaling effects","","",96.1,89.2,76.7,81.9,77.4,68,1.152661680598328,0.2049691276069647,0.17380847527425708,0.7599290502400565,0.39256481774411317,0.40608862512382793,3457]
["High","Q969E2-1","Secretory carrier-associated membrane protein 4 [OS=Homo sapiens]",12,3,7,3,229,25.7,8.82,13.33,"transport","other membranes;ER/Golgi;other cytoplasmic organelle","","SCAMP4","ENSG00000227500; ENSPPAG00000030995; ENSPTRG00000042465","","","",286.2,304.9,314.7,298.2,269.2,299.2,1.0452342487883686,0.06382630277824322,0.36871926364526564,0.43330417219509276,0.6030498555806942,0.21964678220719305,4774]
["High","Q969E8","pre-rRNA-processing protein TSR2 homolog [OS=Homo sapiens]",11,2,3,2,191,20.9,4.39,4.37,"RNA metabolism OR transcription;other metabolic processes","","","TSR2","ENSG00000158526","","","",78.5,83.4,81.3,73.6,70.5,73.7,1.1166207529843892,0.15913927472667846,0.008679699703794347,2.061495300081697,0.07789781067497271,1.10847474804168,870]
["High","Q969M3","Protein YIPF5 [OS=Homo sapiens]",5,1,2,1,257,28,4.36,5.15,"transport;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","","YIPF5","ENSG00000145817","","","",181.7,182.2,194.7,168.8,156.5,169.3,1.1293974929235744,0.1755533338900118,0.023266201023482074,1.6332745238567838,0.12902166022112785,0.889337374004242,1408]
["High","Q969S9","Ribosome-releasing factor 2, mitochondrial [OS=Homo sapiens]",5,5,5,4,779,86.5,6.51,9.43,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","other molecular function","GFM2","ENSG00000164347","","Mitochondrial translation termination","",292,300.1,281.3,323.7,298.6,310.4,0.9364211429184092,-0.09477058628196487,0.09472893320058025,1.023517353518309,0.2760894029227811,0.5589502624678826,2679]
["High","Q969V3","Nicalin [OS=Homo sapiens]",19,9,35,9,563,62.9,6.89,107.04,"protein metabolism;other biological processes","other membranes;ER/Golgi;other cell component","translation activity;other molecular function","NCLN","ENSG00000125912","","","",872.8,861.3,853.7,860.9,869.7,899.1,0.9840666235692285,-0.02317210225051855,0.3370164715630932,0.47234887261784764,0.5745468580708804,0.2406745459630814,4580]
["High","Q969Z3-1","Mitochondrial amidoxime reducing component 2 [OS=Homo sapiens]",7,2,7,1,335,38,9.16,17.82,"other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;other cytoplasmic organelle","other molecular function","MTARC2","ENSG00000117791","","Phase I - Functionalization of compounds","",119.8,79.7,116.3,88.5,94.3,98.1,1.124243503025988,0.16895454673383883,0.4254540353430322,0.37114735279483385,0.6471741881859333,0.18897881239696118,5133]
["High","Q96A54","adiponectin receptor protein 1 [OS=Homo sapiens]",8,2,2,2,375,42.6,7.02,4.36,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","ADIPOR1","ENSG00000159346","AMP-activated protein kinase (AMPK) signaling; Leptin and adiponectin; Nonalcoholic fatty liver disease","AMPK inhibits chREBP transcriptional activation activity","AMPK signaling pathway; Longevity regulating pathway; Adipocytokine signaling pathway; Non-alcoholic fatty liver disease; Alcoholic liver disease",42.8,45,42.3,33,32.3,34.3,1.3062248995983938,0.3854033146497148,5.5937513659646892E-4,3.2522968412875697,0.02286702129081272,1.6407904038766616,191]
["Medium","Q96A83","Collagen alpha-1(XXVI) chain [OS=Homo sapiens]",2,1,2,1,441,45.4,7.31,3.96,"other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","COL26A1","ENSG00000160963","","Collagen degradation; Collagen chain trimerization","Protein digestion and absorption",98,103.4,100.7,96.3,83.8,80.8,1.1579149099271753,0.21152923991048891,0.05142783649433715,1.288801745527919,0.1977097722047191,0.7039718642740904,2031]
["Medium","Q96AG3","Solute carrier family 25 member 46 [OS=Homo sapiens]",3,1,1,1,418,46.1,7.43,2.43,"cell organization and biogenesis","other membranes;mitochondrion","","SLC25A46","ENSG00000164209","","","",128,104.1,131.5,97.6,111.2,97.9,1.185523312683404,0.24552403292708755,0.12241346159615092,0.9121708209530344,0.3193465780630626,0.4957377331345904,2993]
["Medium","Q96AN5-1","Transmembrane protein 143 [OS=Homo sapiens]",3,1,1,1,459,51.7,9.67,0,"","other membranes;mitochondrion","","TMEM143","ENSG00000161558","","","",26.7,27.2,21.9,17.9,22.6,21.1,1.2305194805194803,0.29926749747619014,0.09624187961260056,1.0166359037749322,0.2788336163321652,0.5546548686390542,2695]
["Medium","Q96AY2","crossover junction endonuclease EME1 [OS=Homo sapiens]",4,1,1,1,570,63.2,7.05,0,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EME1","ENSG00000154920","","Fanconi Anemia Pathway; Resolution of D-loop Structures through Holliday Junction Intermediates","Homologous recombination; Fanconi anemia pathway",19.1,12.9,15.4,17.3,22.3,18.2,0.8200692041522492,-0.2861824336024197,0.2171735074796922,0.663193154484303,0.44682233106757224,0.34986513005716674,3795]
["High","Q96B01","RAD51-associated protein 1 [OS=Homo sapiens]",13,4,8,4,352,38.4,9.11,14.53,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity","RAD51AP1","ENSG00000111247","","Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function","",434.1,476.8,457.3,793.7,739.3,709.5,0.6101226309921962,-0.7128288500097604,4.5297612810828083E-4,3.3439246847510176,0.020804927107467393,1.681833801470656,170]
["High","Q96BD8","Spindle and kinetochore-associated protein 1 [OS=Homo sapiens]",13,3,3,3,255,29.5,7.12,7.08,"cell cycle OR cell proliferation;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity","SKA1","ENSG00000154839; ENSG00000262634","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",187,192.5,147.1,201.7,169.8,174.6,0.9642922541659037,-0.05245763542820093,0.7278927423206485,0.1379326108656543,0.8559317066324734,0.0675608855750364,6640]
["High","Q96BN8","Ubiquitin thioesterase otulin [OS=Homo sapiens]",33,12,29,12,352,40.2,5.47,26.38,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","OTULIN","ENSG00000154124","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TNFR1 signaling","",1091.1,1143.3,1130.5,1230,1167.7,1127.1,0.95463572401271,-0.06697776950538326,0.18990397663274391,0.7214659409418929,0.4125682386055828,0.38450420905621246,3594]
["High","Q96BR6-1","Zinc finger protein 669 [OS=Homo sapiens]",11,4,7,2,464,52.6,8.72,18.07,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF669","ENSG00000188295","","Generic Transcription Pathway","Herpes simplex virus 1 infection",164.6,188.1,172.8,141.4,125.3,170.4,1.2022420498741704,0.26572738606387164,0.11884164559820709,0.9250313431585729,0.31412172269153726,0.5029020294758682,2954]
["High","Q96BY7","autophagy-related protein 2 homolog B [OS=Homo sapiens]",2,4,6,4,2078,232.6,5.76,9.7,"cell organization and biogenesis;other metabolic processes;transport","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","ATG2B","ENSG00000066739","Alzheimer's disease and miRNA effects; Alzheimer's disease","","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration",308.7,301.5,298.5,337.8,309,310.5,0.9492322156063931,-0.07516703048393937,0.1749415698627895,0.7571069805905254,0.39409803158934226,0.4043957343097882,3466]
["High","Q96C36","Pyrroline-5-carboxylate reductase 2 [OS=Homo sapiens]",25,7,29,6,320,33.6,7.77,64.53,"other metabolic processes;stress response","mitochondrion","other molecular function","PYCR2","ENSG00000143811","Metabolic reprogramming in colon cancer","Glutamate and glutamine metabolism","Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids",1355.3,1379.3,1340.4,1252.2,1351.1,1367.5,1.026241563412914,0.037370361859469334,0.4096294339227308,0.3876088446812713,0.6363682093252452,0.1962915242791931,5026]
["High","Q96C92-4","Isoform 4 of Serologically defined colon cancer antigen 3 [OS=Homo sapiens]",15,4,5,4,362,40,4.88,9.17,"","","","ENTR1","","","","",95.1,98.5,112.2,101.7,104.3,105.1,0.9829636772741883,-0.024789988173577245,0.7567692863926677,0.12103650216236538,0.8720269463037116,0.05947009482638047,6776]
["Medium","Q96CN4","EVI5-like protein [OS=Homo sapiens]",1,1,1,1,794,91.3,5.34,1.95,"transport;other biological processes","","enzyme regulator activity;other molecular function","EVI5L","ENSG00000142459","","","",40.1,32.9,42.4,30.2,27.2,29.6,1.3264367816091955,0.40755591790939194,0.03449089704580395,1.4622955102723174,0.15639078056541073,0.805788852731318,1722]
["High","Q96CS7-1","Pleckstrin homology domain-containing family B member 2 [OS=Homo sapiens]",14,3,5,3,222,24.7,5.39,7.1,"other biological processes","other membranes;other cytoplasmic organelle","other molecular function","PLEKHB2","ENSG00000115762","","","",328.1,376.2,383.9,413.4,427.2,403.3,0.8748291663316987,-0.19292677502643166,0.05068379019257748,1.2951309155294588,0.19620180159823744,0.7072970090835888,2017]
["High","Q96CW6","Probable RNA polymerase II nuclear localization protein SLC7A6OS [OS=Homo sapiens]",42,7,10,7,309,35,4.6,22.52,"transport;developmental processes;other biological processes","nucleus;other cell component","","SLC7A6OS","ENSG00000103061","","","",330.4,333.4,326.6,312.9,349.2,337.2,0.9910937656359452,-0.012906540181242617,0.7981952089833401,0.09789088331514094,0.8957039654702385,0.047835503068075685,6958]
["High","Q96D71","RalBP1-associated Eps domain-containing protein 1 [OS=Homo sapiens]",12,8,9,8,796,86.6,5.69,18.76,"transport","plasma membrane;other membranes;cytosol","other molecular function","REPS1","ENSG00000135597","","Cargo recognition for clathrin-mediated endocytosis","",420.3,456.4,476.9,461.1,468.4,414.2,1.0073677160080374,0.010590401543095974,0.8960257068386199,0.047679530317778024,0.9518596896593122,0.0214270647433375,7350]
["High","Q96DE0","U8 snoRNA-decapping enzyme [OS=Homo sapiens]",25,5,13,4,195,21.3,6.89,32.88,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT16","ENSG00000198585","","Phosphate bond hydrolysis by NUDT proteins","Purine metabolism; Metabolic pathways; RNA degradation",567.7,518.9,522.9,520.1,482,515.3,1.06069592724397,0.08501113398064586,0.19420753765751525,0.7117339180967208,0.4173885092292538,0.3794595113008001,3633]
["High","Q96DM3","Uncharacterized protein C18orf8 [OS=Homo sapiens]",6,3,4,3,657,74.9,7.83,7.57,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle","","RMC1","ENSG00000141452","","","",84.2,90.8,86.7,81.5,78.9,68,1.1457968476357268,0.19635127368519198,0.07169355699704512,1.144519872035964,0.237397494924906,0.6245238681363988,2358]
["High","Q96DU9-1","Polyadenylate-binding protein 5 [OS=Homo sapiens]",5,2,14,1,382,43.3,9.51,32.73,"","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity","PABPC5","ENSANAG00000005063; ENSCCAG00000032154; ENSG00000174740; ENSGGOG00000007622; ENSNLEG00000035086; ENSPPYG00000020526; ENSPTRG00000022078","","","mRNA surveillance pathway; RNA degradation",92.5,87.5,91,78.3,70,79.9,1.1875547765118315,0.247994059952552,0.013837335027310582,1.8589475438661223,0.09715999270974912,1.0125125264535255,1112]
["High","Q96DZ1","Endoplasmic reticulum lectin 1 [OS=Homo sapiens]",10,4,8,4,483,54.8,6.28,15.24,"protein metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi","other molecular function","ERLEC1","ENSG00000068912","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis","Protein processing in endoplasmic reticulum",187.4,190.9,175.2,147.6,168.4,161.7,1.1586769939292445,0.21247844019764936,0.031198125448195477,1.505871499954706,0.1498124006762056,0.8244522365541199,1626]
["High","Q96E52-1","Metalloendopeptidase OMA1, mitochondrial [OS=Homo sapiens]",6,3,4,3,524,60.1,9.25,7.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion","other molecular function","OMA1","ENSG00000162600","","Regulation of Apoptosis","Spinocerebellar ataxia",187.3,152.8,172,181.1,184.7,213.5,0.8839979285344383,-0.17788510592291198,0.19251797463404483,0.7155287159219856,0.41524318948691213,0.38169748179651597,3620]
["High","Q96ED9-1","Protein Hook homolog 2 [OS=Homo sapiens]",13,8,8,8,719,83.2,5.47,19.23,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","HOOK2","ENSG00000095066","","","",303.5,312.3,291.8,311.8,295.8,306.8,0.9925634295713035,-0.010768794542140947,0.7800501044611691,0.10787750065293182,0.8843663736943237,0.05336777897961661,6887]
["High","Q96EK5","KIF1-binding protein [OS=Homo sapiens]",16,8,19,8,621,71.8,5.49,37.08,"transport;developmental processes;other biological processes","cytoskeleton;mitochondrion","cytoskeletal activity","KIFBP","ENSG00000198954","","","",889.4,869.5,842.6,766.6,773.7,827.3,1.0987920256800132,0.13591834541933953,0.029336352017415513,1.5325938917608481,0.14488187005185346,0.8389859570344218,1581]
["High","Q96EP0-1","E3 ubiquitin-protein ligase RNF31 [OS=Homo sapiens]",18,12,18,12,1072,119.6,6.57,29.82,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RNF31","ENSG00000092098; ENSG00000285152","","Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway","Necroptosis; NOD-like receptor signaling pathway; Shigellosis",541.4,534.9,533.1,507.3,481,486.9,1.0909707158351412,0.12561237692601904,0.005874019381576256,2.231064624837779,0.06450681199908215,1.19039442090891,711]
["High","Q96ES7","SAGA-associated factor 29 [OS=Homo sapiens]",29,5,6,5,293,33.2,8.1,10.71,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SGF29","ENSG00000176476","","HATs acetylate histones","",129.9,126.7,117.9,107.8,98.7,110.1,1.1828806064434616,0.24230446320893204,0.01813002010477662,1.7416017143055555,0.11225947420943366,0.9497769962200019,1261]
["High","Q96EX3","Wd repeat-containing protein 34 [OS=Homo sapiens]",8,3,3,3,536,57.8,6.64,3.04,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","DYNC2I2","ENSG00000119333","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 3q29 copy number variation syndrome","Intraflagellar transport","",71.4,67.4,70,73.5,76,73.3,0.9371633752244166,-0.09362752077014712,0.03292539180021606,1.4824690483886709,0.1535731536296816,0.8136846973872768,1674]
["High","Q96F44-1","E3 ubiquitin-protein ligase TRIM11 [OS=Homo sapiens]",17,6,10,6,468,52.7,5.69,23.99,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM11","ENSG00000154370; ENSPPAG00000018913; ENSPTRG00000002071","","Antigen processing: Ubiquitination & Proteasome degradation","",420.3,435.9,458.9,412.1,380.6,375,1.1262310524963601,0.17150283460753254,0.03792111169418959,1.4211189393831507,0.16376550890942052,0.7857775608638599,1808]
["High","Q96F46","Interleukin-17 receptor A [OS=Homo sapiens]",4,2,2,2,866,96.1,5.21,2.5,"stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","IL17RA","ENSG00000177663","IL-17 signaling pathway","Interleukin-17 signaling","Cytokine-cytokine receptor interaction; IL-17 signaling pathway; Alcoholic liver disease",17.4,14.8,16.4,14.6,8.2,13.1,1.3537604456824512,0.4369724697827296,0.11098766799456854,0.9547252736407281,0.30048256300332565,0.5221807250294841,2884]
["High","Q96FL9","Polypeptide N-acetylgalactosaminyltransferase 14 [OS=Homo sapiens]",8,3,5,3,552,64.3,7.72,6.62,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT14","ENSG00000158089","","O-linked glycosylation of mucins","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways",110.8,104.5,99.9,127.1,128,119.5,0.8414308595835558,-0.24908336478666912,8.856735230012831E-3,2.052726338258089,0.07876240168102526,1.1036810495055562,878]
["High","Q96FW1","Ubiquitin thioesterase otub1 [OS=Homo sapiens]",50,10,66,10,271,31.3,4.94,168.33,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","other molecular function","OTUB1","ENSG00000167770","","Ub-specific processing proteases; Ovarian tumor domain proteases","",2449.1,2325.1,2303.3,2256.9,2628.6,2393,0.9723844198667307,-0.04040131707098395,0.599591287614832,0.22214468631123716,0.7751007903471205,0.11064182027373365,6040]
["High","Q96G21","U3 small nucleolar ribonucleoprotein protein IMP4 [OS=Homo sapiens]",34,8,17,8,291,33.7,9.47,36.47,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","IMP4","ENSG00000136718","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",447.7,427.9,454.8,414.3,441.9,444.2,1.0230698246693324,0.03290461259691302,0.46959996211275246,0.32827194679924776,0.6833090764398754,0.16538281047653253,5366]
["High","Q96G97-4","Isoform 3 of Seipin [OS=Homo sapiens]",15,6,13,6,462,51.1,5.27,25.3,"","","","BSCL2","","","","",1084,1071.8,1060.7,1091.8,1123.7,1127.9,0.9620446252318,-0.05582427874296014,0.03303111406096704,1.481076778340945,0.15369900988559632,0.8133289301749913,1678]
["High","Q96GM5","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [OS=Homo sapiens]",57,22,71,21,515,58.2,9.25,144.54,"cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SMARCD1","ENSG00000066117","Tumor suppressor activity of SMARCB1; Thermogenesis","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Thermogenesis; Hepatocellular carcinoma",2075.6,2150,2082.4,2191.5,2277.6,2230.2,{"$f":"AVERAGE(T5506:V5506)/AVERAGE(W5506:Y5506)","v":0.9415909124833938},{"$f":"LOG(Z5506,2)","v":-0.08682769823488788},{"$f":"TTEST(T5506:V5506,W5506:Y5506,2,2)","v":0.01925382534091178},{"$f":"-LOG10(AB5506)","v":1.7154829721605258},{"$f":"AB5506*7808/AF5506","v":0.1155525505471477},{"$f":"-LOG10(AD5506)","v":0.9372204640634768},1301]
["High","Q96GQ5-1","RUS1 family protein C16orf58 [OS=Homo sapiens]",5,2,5,2,468,51,6.93,16.07,"","other membranes","","C16orf58; RUSF1","ENSG00000140688","","","",177.2,188.6,166.1,164.1,151.3,149,1.1453488372093024,0.1957870647542784,0.04846717046984192,1.3145523337990823,0.19103062444650462,0.718897004678994,1981]
["Medium","Q96GX2","Ataxin-7-like protein 3B [OS=Homo sapiens]",10,1,1,1,97,10.8,4.36,2.57,"other biological processes","other cell component","","ATXN7L3B","ENSG00000253719","","","",144,116.5,109.4,126.8,125.6,107.1,1.0289290681502086,0.041143529797335036,0.7925005610158253,0.10100042167047467,0.8923917479682094,0.049444454332217155,6934]
["High","Q96H22","Centromere protein N [OS=Homo sapiens]",9,2,3,2,339,39.5,9.13,6.1,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","","CENPN","ENSG00000166451","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere","",86,106.8,97.5,97.5,97.4,87.5,1.0279745042492918,0.03980448335548144,0.720969052050183,0.1420833771838971,0.8518956353522743,0.06961360683758754,6608]
["High","Q96HB5-1","Coiled-coil domain-containing protein 120 [OS=Homo sapiens]",1,1,1,1,630,67.5,9.38,2.12,"cell organization and biogenesis;other biological processes","cytoskeleton;other cytoplasmic organelle;other cell component","","CCDC120","ENSG00000147144","","","",31.2,32.3,28.8,26.2,23.8,29,1.1683544303797468,0.224477994581309,0.07189749729744474,1.1432862268469737,0.23756904735440054,0.6242101438207074,2363]
["High","Q96HP0","Dedicator of cytokinesis protein 6 [OS=Homo sapiens]",14,23,38,20,2047,229.4,6.74,59.64,"signal transduction","cytosol;other cell component","enzyme regulator activity","DOCK6","ENSG00000130158","","CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production","",823.7,905.6,834.9,783.6,768.7,798.6,1.0907312093240888,0.12529561976211945,0.058291465944980796,1.2343950226731706,0.21169291446437677,0.6742936779301406,2150]
["High","Q96I27","Zinc finger protein 625 [OS=Homo sapiens]",21,2,3,1,306,34.7,8.98,9.54,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF625","ENSG00000257591","","Generic Transcription Pathway","",32.1,27.9,24.2,28.9,25.3,26.8,1.039506172839506,0.05589832529440888,0.6926718450012372,0.15947246475106916,0.8354003345334662,0.07810535515898809,6474]
["High","Q96II8-1","Leucine-rich repeat and calponin homology domain-containing protein 3 [OS=Homo sapiens]",19,11,15,11,777,86,6.71,30.21,"cell organization and biogenesis","cytosol;other cell component","","LRCH3","ENSG00000186001","","","",533,496.2,493.6,566.5,479.8,549.4,0.9543147208121829,-0.0674629677787386,0.45506638542512495,0.3419252435170036,0.6721828107074113,0.1725125976540597,5286]
["High","Q96IY1","Kinetochore-associated protein NSL1 homolog [OS=Homo sapiens]",22,5,8,5,281,32.1,6.79,9.22,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","","NSL1","ENSG00000117697","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",295.5,272.5,265.7,263.6,235.8,254.9,1.1052631578947367,0.14438990933517465,0.0957659772862253,1.0187887550263495,0.2780739124770722,0.5558397525910156,2689]
["High","Q96JA1","Leucine-rich repeats and immunoglobulin-like domains protein 1 [OS=Homo sapiens]",2,2,2,2,1093,119,7.09,2.24,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","","LRIG1","ENSG00000144749","","Signaling by EGFR; Negative regulation of MET activity","",87.2,86.4,92.7,90.1,77.5,87.6,1.0434952978056427,0.06142409944574487,0.44105872475574737,0.3555035825515654,0.6602351462601371,0.1803013606167938,5216]
["High","Q96JC9","ELL-associated factor 1 [OS=Homo sapiens]",18,3,4,3,268,29,5.4,9.02,"other biological processes","non-structural extracellular;nucleus;other cell component","other molecular function","EAF1","ENSG00000144597","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",90.3,85.4,99.6,87,66.3,84.5,1.157695542472666,0.2112558948499053,0.18158070756012407,0.7409302959320382,0.40255030227979804,0.39517984290466085,3522]
["High","Q96JJ7-1","Protein disulfide-isomerase TMX3 [OS=Homo sapiens]",24,9,19,9,454,51.8,4.91,47.36,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TMX3","ENSG00000166479; ENSGGOG00000005485","","Platelet degranulation","",637.2,634.2,643.3,617.6,656.6,617.3,1.012265397832408,0.017587588391007176,0.5927164451367049,0.22715302293299977,0.7700382701543081,0.11348769027710384,6010]
["High","Q96JM7","Lethal(3)malignant brain tumor-like protein 3 [OS=Homo sapiens]",11,7,9,6,780,88.3,6.46,13.67,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","other molecular function","L3MBTL3","ENSG00000198945","","","",313.9,307.8,296,390.7,390.6,411,0.7696888367021724,-0.3776527717759074,4.3729889293429603E-4,3.3592216221134894,0.020323986643041567,1.691991099180717,168]
["High","Q96JP5-1","E3 ubiquitin-protein ligase ZFP91 [OS=Homo sapiens]",13,5,6,5,570,63.4,7.36,12.7,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","other molecular function","ZFP91","ENSG00000186660","","","",226.6,244.9,235.8,217.4,242.3,225.8,1.0318016046681253,0.04516559529865615,0.4657225388214678,0.33187274371010855,0.6810941343169171,0.166792859909382,5339]
["High","Q96K31-1","Uncharacterized protein C8orf76 [OS=Homo sapiens]",4,2,2,2,380,43.2,5.43,4.94,"","","","C8orf76","ENSG00000189376","","","",143.4,130.5,167.2,137.8,158.5,147.4,0.9941401848095559,-0.008478792728006486,0.9472127345674374,0.023552471817111693,0.9753180840699659,0.010853723145038819,7583]
["High","Q96KM6","zinc finger protein 512B [OS=Homo sapiens]",7,5,7,5,892,97.2,9.83,9.47,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512B","ENSG00000196700","","RHOV GTPase cycle","",168,181,174.5,183.5,179.3,185.1,0.9554663259718927,-0.06572306648780872,0.12040127442149559,0.919368916140537,0.31663629191075704,0.49943930907794615,2969]
["High","Q96KR1","Zinc finger RNA-binding protein [OS=Homo sapiens]",34,26,83,26,1074,116.9,9.04,188.67,"","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZFR","ENSG00000056097","Exercise-induced circadian regulation","","",3137.3,3265.7,3247.7,3220.7,3190.7,3241.6,0.9997617321040092,-3.4378887050103528E-4,0.9865567802837175,0.005877914310154575,0.9941966107970143,2.527721698592362E-3,7748]
["High","Q96L73-1","Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [OS=Homo sapiens]",4,8,9,8,2696,296.5,8.03,12.95,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD1","ENSG00000165671","Histone modifications; Pathways affected in adenoid cystic carcinoma","PKMTs methylate histone lysines","Lysine degradation; Metabolic pathways",312.1,325,323.4,401.4,397.5,405.9,0.7972277556440904,-0.3269361561190385,6.677482778421095E-5,4.175387223373431,0.011334301203024328,1.9456052503963694,46]
["High","Q96LR4","Protein FAM19A4 [OS=Homo sapiens]",8,1,1,1,140,15.7,8.9,4.32,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","TAFA4","ENSG00000163377","","","",84,78,78.7,70.6,71.9,70.8,1.128457571495546,0.17435217613392523,0.009200558254899058,2.036185820516768,0.07964296990493552,1.0988525534000744,902]
["High","Q96LR5","Ubiquitin-conjugating enzyme E2 E2 [OS=Homo sapiens]",34,6,26,3,201,22.2,7.71,57.57,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","UBE2E2","ENSG00000182247","","Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin mediated proteolysis",884.6,895.9,888.1,968.6,1052.3,1051.1,0.8686848958333333,-0.20309514185071104,0.008528507377597411,2.0691269705201174,0.07770196686613838,1.1095679877846802,857]
["High","Q96ME7","Zinc finger protein 512 [OS=Homo sapiens]",20,13,35,13,567,64.6,9.76,77.31,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512","ENSG00000243943","","","",869.8,856.2,894.3,1019.9,1016.9,1040.7,0.8514378554021123,-0.23202686031531036,3.434979571312034E-4,3.4640758414553297,0.01862522256444747,1.7298985288919442,144]
["High","Q96MR9","Zinc finger protein 560 [OS=Homo sapiens]",2,2,4,1,790,91.1,8.69,5.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF560","ENSG00000198028","","Generic Transcription Pathway","Herpes simplex virus 1 infection",67.5,75.1,70.7,68.8,67.4,59.9,1.0877103518612954,0.12129443014842269,0.18003241947950357,0.7446492819340225,0.40036830854342464,0.39754030674073826,3511]
["High","Q96MW5","Conserved oligomeric Golgi complex subunit 8 [OS=Homo sapiens]",11,6,10,6,612,68.4,5.2,24.18,"transport","other membranes;ER/Golgi","","COG8","ENSG00000213380","","COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",799.3,835.2,779,832,825.4,839.6,0.9665598718462154,-0.049068994483609886,0.17561655389490818,0.7554345492137078,0.39402702666995487,0.4044739885016533,3480]
["High","Q96N21-1","AP-4 complex accessory subunit tepsin [OS=Homo sapiens]",4,1,3,1,525,55.1,7.03,2.75,"","other membranes;cytosol;ER/Golgi;nucleus;other cell component","","TEPSIN","ENSG00000167302","","","",27.4,30.5,34.6,35.5,37.2,30.9,0.8928571428571429,-0.16349873228287934,0.2581198293875754,0.5881786306254234,0.49312445017327833,0.3070434636783815,4087]
["High","Q96N67","Dedicator of cytokinesis protein 7 [OS=Homo sapiens]",22,37,86,34,2140,242.4,6.8,150.9,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other cell component","enzyme regulator activity;other molecular function","DOCK7","ENSG00000116641","","CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production; MET activates RAP1 and RAC1","",2742.6,2819.4,2720.9,2905.6,2914.1,2922.7,0.9474400622254759,-0.07789341774109072,0.007193658012329007,2.1430502124570054,0.0714606638171309,1.145932953837778,786]
["High","Q96NT0","Coiled-coil domain-containing protein 115 [OS=Homo sapiens]",7,1,1,1,180,19.7,6.95,3.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","CCDC115","ENSG00000136710","","RHOA GTPase cycle","",33.7,35.6,43.7,41.2,36,40.1,0.9633418584825235,-0.053880240725958296,0.6991482577471156,0.15543072025696883,0.8386771541695313,0.07640518714021653,6509]
["High","Q96P70","Importin-9 [OS=Homo sapiens]",29,23,79,23,1041,115.9,4.81,153.34,"transport","cytosol;nucleus;other cell component","other molecular function","IPO9","ENSG00000198700","","","Nucleocytoplasmic transport",2895.6,3015.1,2942.8,2852.7,3128.2,3065.9,0.9786333289118804,-0.031159678009419774,0.5151959227093766,0.28802758266653955,0.717433523187946,0.14421833410639864,5607]
["High","Q96PK6-1","RNA-binding protein 14 [OS=Homo sapiens]",46,28,138,28,669,69.4,9.67,261.35,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RBM14","ENSCATG00000036313; ENSG00000239306; ENSGGOG00000014455; ENSMFAG00000003827; ENSMLEG00000024601; ENSMMUG00000020363; ENSPANG00000004924; ENSPPYG00000003015; ENSRBIG00000043267; ENSRROG00000044302","Ciliary landscape","RUNX2 regulates bone development","",5105.8,5241.5,5097.5,4797.6,4783.3,4859.1,1.0695844875346259,0.09705044690968859,3.021260636441557E-3,2.51981180763444,0.047753042609991254,1.3209989518994514,494]
["High","Q96PV7-1","Protein FAM193B [OS=Homo sapiens]",8,6,7,6,902,96.5,7.9,7.56,"","nucleus;other cell component","","FAM193B","ENSG00000146067","","","",297.7,284,286.8,291.9,254.3,242.4,1.1013187927973624,0.1392321384899387,0.1607037821724489,0.7939739019715967,0.37658317262979624,0.4241390900477112,3332]
["High","Q96Q05","Trafficking protein particle complex subunit 9 [OS=Homo sapiens]",5,5,5,5,1148,128.4,6.62,2.54,"developmental processes;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC9","ENSG00000167632","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",111.7,130.7,138.6,128.1,128.5,113.9,1.0283400809716599,0.04031745518748811,0.7262000560303642,0.1389437219148959,0.8547136022739047,0.06817938443972402,6634]
["High","Q96QC0","Serine/threonine-protein phosphatase 1 regulatory subunit 10 [OS=Homo sapiens]",27,22,38,22,940,99,9.17,64.22,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","PPP1R10","ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104","","","",2475.8,2499.9,2340.1,2230.5,1991,2143.6,{"$f":"AVERAGE(T5698:V5698)/AVERAGE(W5698:Y5698)","v":1.1493613611726445},{"$f":"LOG(Z5698,2)","v":0.20083245508499128},{"$f":"TTEST(T5698:V5698,W5698:Y5698,2,2)","v":0.02101127292810778},{"$f":"-LOG10(AB5698)","v":1.677547635889774},{"$f":"AB5698*7808/AF5698","v":0.12125352477654511},{"$f":"-LOG10(AD5698)","v":0.9163056278287617},1353]
["High","Q96QU8","Exportin-6 [OS=Homo sapiens]",6,6,11,6,1125,128.8,6.35,18.38,"transport","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","XPO6","ENSG00000169180","","","Nucleocytoplasmic transport",408.9,409.4,447.2,416.2,380.9,703.9,0.8431045969353764,-0.24621646951000428,0.48874029379094996,0.31092185444495263,0.6987885394469396,0.1556542263218606,5461]
["High","Q96RL1","BRCA1-A complex subunit RAP80 [OS=Homo sapiens]",13,8,8,8,719,79.7,5.45,16.69,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","UIMC1","ENSG00000087206","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","Homologous recombination",455.8,486.6,525.3,590,531.6,583.3,0.8608716053727492,-0.21613001185839256,0.04423636245344215,1.3542205921768637,0.1809311252155455,0.7424867159118951,1909]
["High","Q96RQ1","Endoplasmic reticulum-Golgi intermediate compartment protein 2 [OS=Homo sapiens]",13,4,9,4,377,42.5,6.77,16.2,"transport","other membranes;ER/Golgi;nucleus;other cell component","","ERGIC2","ENSG00000087502","","","",414.8,416.7,412,408.2,435.1,410.7,0.9916267942583732,-0.012130840585132377,0.707667310170715,0.15017086563591014,0.8442270982143534,0.07354071186404935,6545]
["High","Q96RS6","NudC domain-containing protein 1 [OS=Homo sapiens]",29,12,33,12,583,66.7,5.11,51.84,"other biological processes","cytosol;nucleus","","NUDCD1","ENSG00000120526","","","",825.7,854.9,898.7,813.7,963.3,862.5,0.9771926501231295,-0.03328508235749933,0.7025069711218287,0.1533493618076206,0.84063975946655,0.07539007315930375,6525]
["High","Q96RW7-1","Hemicentin-1 [OS=Homo sapiens]",1,3,3,3,5635,613,6.49,4.34,"cell adhesion;cell cycle OR cell proliferation;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","HMCN1","ENSG00000143341","","","",83,80.3,81,86,75.9,89.4,0.9721448467966575,-0.04075680761339898,0.6026011300142089,0.21997005826094368,0.7768052869656501,0.10968782726561005,6057]
["High","Q96S55-1","ATPase WRNIP1 [OS=Homo sapiens]",12,7,15,7,665,72.1,6.1,31.84,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","WRNIP1","ENSG00000124535; ENSPTRG00000017666","","","",495.2,475.7,499.9,514.3,494.3,502.7,0.9732018791768676,-0.039188988876813026,0.22461411332605813,0.6485629589068855,0.4560028592953359,0.3410324341507112,3846]
["High","Q96S99","Pleckstrin homology domain-containing family F member 1 [OS=Homo sapiens]",7,2,2,2,279,31.2,8.24,1.73,"cell organization and biogenesis;other biological processes","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PLEKHF1","ENSG00000166289","","","",78.8,68.6,75.4,84.5,80.6,83.3,0.8969404186795491,-0.1569159408804497,0.05661617717251038,1.247059458336047,0.2097054607983686,0.6783902602179206,2108]
["High","Q96SB8","structural maintenance of chromosomes protein 6 [OS=Homo sapiens]",26,27,50,27,1091,126.2,6.99,113.81,"cell organization and biogenesis;DNA metabolism;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC6","ENSG00000163029","","SUMOylation of DNA damage response and repair proteins","",2536.8,2642.1,2642.2,2683.5,2764.6,2607.1,0.9709380276094943,-0.04254887968955557,0.2459613237853857,0.6091331782101624,0.4786804626411495,0.3199542978999075,4012]
["High","Q96SQ9","Cytochrome P450 2S1 [OS=Homo sapiens]",24,13,55,13,504,55.8,8.62,158.41,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","CYP2S1","ENSG00000167600","Vitamin D receptor pathway; Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II","CYP2E1 reactions; Miscellaneous substrates","Retinol metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways",2407,2300.7,2248.7,2306.2,2330.7,2372.7,0.9924104085825153,-0.010991228327282757,0.7430399467397111,0.1289878374072903,0.8646283016607547,0.06317055291764699,6710]
["High","Q96ST8","Centrosomal protein of 89 kDa [OS=Homo sapiens]",3,3,3,3,783,89.5,6.8,5.59,"cell-cell signaling;cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","","CEP89","ENSG00000121289","","Anchoring of the basal body to the plasma membrane","",197.8,218.3,204.9,197.5,157.1,173.5,1.1759136527172884,0.23378212703640533,0.07857323595454276,1.1047253605338359,0.2504080923808448,0.601351640239733,2450]
["High","Q96T21","selenocysteine insertion sequence-binding protein 2 [OS=Homo sapiens]",13,7,9,7,854,95.4,8.12,24.57,"protein metabolism;other metabolic processes;developmental processes;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","SECISBP2","ENSG00000187742","","Selenocysteine synthesis","",381.4,411.3,383,487.6,408.9,432,0.8849830636055703,-0.17627824905450298,0.11432135363751256,0.9418726418638517,0.3053784225801225,0.5151616525626528,2923]
["High","Q96T51","RUN and FYVE domain-containing protein 1 [OS=Homo sapiens]",25,16,34,14,708,79.8,5.74,68.63,"transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RUFY1","ENSG00000176783; ENSG00000284260","","Synthesis of PIPs at the plasma membrane","Endocytosis",1672.5,1758.4,1756.1,1614.5,1533.5,1519.5,1.1113015532940547,0.15225034724987366,0.013361709281937043,1.8741379816635968,0.09493014201398038,1.022595869428452,1099]
["High","Q96TC7","Regulator of microtubule dynamics protein 3 [OS=Homo sapiens]",20,10,27,10,470,52.1,5.1,37.86,"other biological processes","non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component","cytoskeletal activity","RMDN3","ENSG00000137824","","","",1174.3,1234.7,1231.6,1138.7,1091.4,1129.3,1.0837054235875452,0.11597265181682957,0.0183977201110109,1.7352359924554215,0.11302076996598986,0.9468417383507943,1271]
["High","Q99460","26S proteasome non-ATPase regulatory subunit 1 [OS=Homo sapiens]",51,38,225,38,953,105.8,5.39,535.16,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","PSMD1","ENSG00000173692","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Neutrophil degranulation","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection",9368.1,9290.7,9462.5,9072.2,9569.7,9314.8,1.0058876762994204,0.008469213798353767,0.7363462769747884,0.1329179046662636,0.8606873848232257,0.06515456248317388,6680]
["High","Q99487","Platelet-activating factor acetylhydrolase 2, cytoplasmic [OS=Homo sapiens]",12,3,4,3,392,44,6.89,9.99,"other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PAFAH2","ENSG00000158006","","Platelet homeostasis","Ether lipid metabolism; Metabolic pathways",70.1,69.1,61.8,74.9,65.2,67.7,0.9672762271414822,-0.0480001528379208,0.5933068149701206,0.22672066314591133,0.7701645239046886,0.11341649016313947,6015]
["High","Q99538","Legumain [OS=Homo sapiens]",17,5,17,5,433,49.4,6.55,39.85,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","LGMN","ENSG00000100600","","MHC class II antigen presentation; Trafficking and processing of endosomal TLR; Vitamin D (calciferol) metabolism","Lysosome; Antigen processing and presentation",625.2,601.6,577.5,502,488.4,525.9,1.1899360284904044,0.25088401566731894,0.005489620151397119,2.2604577050689225,0.062210383370259366,1.206137122317913,689]
["High","Q99570","Phosphoinositide 3-kinase regulatory subunit 4 [OS=Homo sapiens]",15,14,32,14,1358,153,7.17,45.52,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIK3R4","ENSG00000196455","Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Ciliopathies; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; DNA damage response (only ATM dependent)","PI3K Cascade; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade","Autophagy; Autophagy; Apelin signaling pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis",880.3,879.1,933.5,805,914.7,861.7,1.0431936158673587,0.0610069457085792,0.36495102145434005,0.4377654164733918,0.5997763787656256,0.22201064223396186,4751]
["High","Q99611","Selenide, water dikinase 2 [OS=Homo sapiens]",9,2,5,2,448,47.3,5.88,5.26,"other metabolic processes","cytosol;other cell component","kinase activity;other molecular function","SEPHS2","ENSG00000179918","Selenium micronutrient network","Selenocysteine synthesis","Selenocompound metabolism; Metabolic pathways",19.8,23.7,21.5,23.6,12.9,21.7,1.1168384879725086,0.15942056500753304,0.5507815114404784,0.25902064650905604,0.7404445663442244,0.13050744954245794,5808]
["High","Q99614","tetratricopeptide repeat protein 1 [OS=Homo sapiens]",48,11,22,11,292,33.5,4.84,48.22,"other biological processes","cytosol","other molecular function","TTC1","ENSG00000113312","","","",1295.2,1170.7,1046.6,1591.2,1078.1,998.6,0.9576324327271735,-0.06245608113737517,0.8075670514574678,0.09282140847792034,0.9020720368783846,0.044758779564966364,6990]
["High","Q99666","RANBP2-like and GRIP domain-containing protein 5/6 [OS=Homo sapiens]",22,37,115,1,1765,198.8,6.42,239.39,"transport;other biological processes","nucleus;other cell component","","RGPD5; RGPD6","ENSG00000015568; ENSG00000183054","","","",154.5,155.7,160.5,201.9,210.3,204.7,0.7630085913438158,-0.3902287932412704,9.267915669912019E-5,4.033017926571584,0.011862932057487384,1.9258079569237159,61]
["High","Q99707","methionine synthase [OS=Homo sapiens]",7,7,10,7,1265,140.4,5.58,16.9,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol","other molecular function","MTR","ENSG00000116984","Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Vitamin B12 disorders; Male infertility","RHOH GTPase cycle; Cobalamin (Cbl, vitamin B12) transport and metabolism; Methylation; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG","Cysteine and methionine metabolism; Selenocompound metabolism; One carbon pool by folate; Metabolic pathways; Biosynthesis of amino acids",224.1,234.2,240.7,244.8,222.1,236.3,0.9940273037542662,-0.008642614880605339,0.8726543011745387,0.059157766404518974,0.9383948193872466,0.027614398503079438,7261]
["High","Q99732","Lipopolysaccharide-induced tumor necrosis factor-alpha factor [OS=Homo sapiens]",4,1,2,1,161,17.1,6.44,4.15,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","LITAF","ENSG00000189067","Intracellular trafficking proteins involved in CMT neuropathy","","Lysosome",225.3,228.5,217.3,237.1,248.2,243.2,0.9212079615648593,-0.11840121517159993,0.014416681147493678,1.84113470669177,0.09917660475738381,1.0035907635622763,1135]
["High","Q99807-1","5-demethoxyubiquinone hydroxylase, mitochondrial [OS=Homo sapiens]",13,2,2,2,217,24.3,8.59,3.09,"other metabolic processes;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","COQ7","ENSG00000167186","","Ubiquinol biosynthesis","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",50.6,38.4,42.7,44.5,49.4,51.6,0.9051546391752577,-0.14376380753913184,0.32914044519043806,0.48261874777621167,0.5666876727777157,0.24665623451369026,4535]
["High","Q99816","tumor susceptibility gene 101 protein [OS=Homo sapiens]",22,10,28,10,390,43.9,6.46,63.9,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TSG101","ENSG00000074319","Ebola virus infection in host; 7q11.23 copy number variation syndrome","HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy","Endocytosis",1565.5,1551.2,1517.9,1607.9,1565.3,1549.7,0.9813038599165768,-0.027228159955388104,0.25897941795398316,0.5867347495256842,0.4936795154747804,0.3065548928348231,4096]
["High","Q99933","BAG family molecular chaperone regulator 1 [OS=Homo sapiens]",26,7,13,7,345,38.8,7.81,33.93,"signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","other molecular function","BAG1","ENSG00000107262","Androgen receptor signaling pathway","Regulation of HSF1-mediated heat shock response","Protein processing in endoplasmic reticulum",489.6,511.6,522,486.5,506.4,456.2,1.0511351873576704,0.07194822742398731,0.22968219783652832,0.6388726647134422,0.4611361791482677,0.3361708032022665,3889]
["High","Q9BPU6","Dihydropyrimidinase-related protein 5 [OS=Homo sapiens]",35,14,40,14,564,61.4,7.2,122.07,"cell organization and biogenesis;developmental processes;signal transduction","cytosol;other cell component","cytoskeletal activity;other molecular function","DPYSL5","ENSG00000157851","","CRMPs in Sema3A signaling","Axon guidance",1655,1575.8,1645.1,1667.9,1640,1677.6,0.9780162471166383,-0.03206966300238055,0.2524861096530659,0.5977625092956528,0.48688850189457605,0.3125704814054308,4049]
["High","Q9BPX5","actin-related protein 2/3 complex subunit 5-like protein [OS=Homo sapiens]",50,6,10,6,153,16.9,6.6,27.79,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity","ARPC5L","ENSG00000136950","Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling pathway","","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",194.2,202.4,165.2,204.1,149.2,162,1.0902386959052979,0.12464403197336944,0.48280466161768476,0.31622854531647887,0.6937318362000152,0.1588083747397154,5434]
["High","Q9BQ69","O-acetyl-ADP-ribose deacetylase MACROD1 [OS=Homo sapiens]",9,3,4,3,325,35.5,9.51,2.4,"protein metabolism;other metabolic processes;stress response","nucleus","other molecular function","MACROD1","ENSG00000133315","","","",142.2,130.9,131.2,132.5,135.3,125,1.029276985743381,0.04163127395700184,0.47134910803457375,0.32665731042626056,0.6844511503689701,0.1646575422447443,5377]
["High","Q9BQB6-1","vitamin K epoxide reductase complex subunit 1 [OS=Homo sapiens]",12,2,4,2,163,18.2,9.36,8.05,"protein metabolism;other metabolic processes;stress response;developmental processes","other membranes;ER/Golgi","other molecular function","VKORC1","ENSG00000167397; ENSPPAG00000037377; ENSPPYG00000007306; ENSPTRG00000008031","","Metabolism of vitamin K","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",374.6,394.1,425.7,341.8,346.4,369.5,1.1292426964167535,0.17535558291210826,0.056834781953849986,1.2453858018331578,0.20981842907596251,0.6781563688855835,2115]
["High","Q9BQE5","apolipoprotein L2 [OS=Homo sapiens]",18,6,7,6,337,37.1,6.74,19.08,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","APOL2","ENSG00000128335","","","",539.4,549.2,542.2,578.6,581.7,625.4,0.9132553060424482,-0.13090986417152914,0.028427149816223442,1.5462666816791695,0.14237279394809021,0.8465729922093758,1559]
["High","Q9BQP7","mitochondrial genome maintenance exonuclease 1 [OS=Homo sapiens]",24,7,16,7,344,39.4,7.68,32.53,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","mitochondrion","other molecular function","MGME1","ENSG00000125871","","","",860.3,947,934.5,1015.8,1006.9,1030.5,0.8980086466657934,-0.1551987585603572,0.020513450442948375,1.6879612834493791,0.11988699181028512,0.9212279369302706,1336]
["High","Q9BQS8","fyve and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",4,5,5,5,1478,166.9,4.92,8.18,"transport;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FYCO1","ENSG00000163820","","","Salmonella infection",126.8,142.9,133.7,149.1,130.8,127,0.9913983779798476,-0.012463196460748996,0.8945527344435917,0.04839405241042256,0.9510713167940583,0.021786915944973173,7344]
["High","Q9BRG1","Vacuolar protein-sorting-associated protein 25 [OS=Homo sapiens]",30,3,5,3,176,20.7,6.34,5.87,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS25","ENSG00000131475","","HCMV Late Events; Endosomal Sorting Complex Required For Transport (ESCRT)","Endocytosis",100.8,107.5,85.3,107.6,116.6,113.4,0.8696682464454976,-0.2014629358639725,0.10712184799266927,0.9701219437808112,0.29450964405871893,0.5309004791692135,2840]
["High","Q9BRP8","Partner of Y14 and mago [OS=Homo sapiens]",27,4,5,4,204,22.6,9.45,10.55,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity","PYM1","ENSG00000170473","","","Nucleocytoplasmic transport; mRNA surveillance pathway",100.7,82.1,81.4,108.5,88.7,74.9,0.9709665564130835,-0.04250649000285089,0.8318267596198435,0.07996711262183911,0.9160653510735879,0.03807354314627027,7090]
["High","Q9BRS8","La-related protein 6 [OS=Homo sapiens]",15,5,7,5,491,54.7,8.25,9.61,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity","LARP6","ENSG00000166173","","","",195.2,199.8,203.9,197.6,172,175.9,1.097891842346471,0.13473593576741713,0.10002338384344472,0.9998984571301128,0.2838904329515145,0.546849242861161,2751]
["High","Q9BRT9","DNA replication complex GINS protein SLD5 [OS=Homo sapiens]",34,6,14,6,223,26,4.98,27.89,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes","nucleus;other cell component","","GINS4","ENSG00000147536","","Unwinding of DNA","",656.3,635.2,584.5,643.9,573.8,574.3,1.0468750000000002,0.06608919045777274,0.42510545229343205,0.37150332484758863,0.6471482494652208,0.18899621925470683,5129]
["High","Q9BS26","Endoplasmic reticulum resident protein 44 [OS=Homo sapiens]",47,18,54,18,406,46.9,5.26,119.58,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","ERP44","ENSG00000023318","","Neutrophil degranulation","",2392.1,2346.8,2394.4,2296.8,2288.6,2267,1.0409929367812736,0.05796027987152846,6.335506414425921E-3,2.1982186650424853,0.0670293144767447,1.1737352222068915,738]
["High","Q9BSD7","Cancer-related nucleoside-triphosphatase [OS=Homo sapiens]",72,11,29,11,190,20.7,9.54,77.55,"","","other molecular function","NTPCR","ENSG00000135778","","","Purine metabolism; Thiamine metabolism; Metabolic pathways",1378.8,1389.4,1462.5,1405.6,1486.1,1396.2,0.986660136663635,-0.01937487300966649,0.6489653649417955,0.18777848072819736,0.8075094134606438,0.09285240622263767,6275]
["High","Q9BSJ2-1","Gamma-tubulin complex component 2 [OS=Homo sapiens]",12,10,14,10,902,102.5,6.84,32.13,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","TUBGCP2","ENSG00000130640","15q11.2 copy number variation syndrome","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","",533.2,529,515.7,542.8,557.7,571.1,0.9439459200765735,-0.08322388685983835,0.03256334029873348,1.4872710522195267,0.1523394613855668,0.8171875842401379,1669]
["High","Q9BSQ5-1","Cerebral cavernous malformations 2 protein [OS=Homo sapiens]",16,5,5,5,444,48.8,5.54,5.73,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","mitochondrion;other cell component","","CCM2","ENSG00000136280","","","",222.4,211.4,223.8,193.3,210.8,221.1,1.051823416506718,0.07289252068201864,0.29690881737577374,0.5273769048600603,0.5341622225967837,0.2723268297139356,4340]
["High","Q9BSY9","Desumoylating isopeptidase 2 [OS=Homo sapiens]",35,3,17,3,194,21.4,4.92,29.12,"protein metabolism;other metabolic processes","other cell component","other molecular function","DESI2","ENSG00000121644","","","",692.9,634.1,676.1,596.3,566.1,578.6,1.150545663411832,0.2023182430756718,0.011099762208822419,1.9546863250423927,0.0859791104429419,1.065607052493264,1008]
["High","Q9BT67","NEDD4 family-interacting protein 1 [OS=Homo sapiens]",13,2,3,2,221,24.9,4.68,7.2,"protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","NDFIP1","ENSG00000131507","","","",100.2,91.5,81,117,128.2,136.6,0.714248297537978,-0.4855024024886743,0.010181336858055046,1.9921951933197313,0.08280820644551438,1.0819266217006642,960]
["High","Q9BTC0","Death-inducer obliterator 1 [OS=Homo sapiens]",27,44,105,44,2240,243.7,7.88,264.18,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytoskeleton;nucleus;other cell component","other molecular function","DIDO1","ENSG00000101191","","","",3909.9,4288.3,4222.8,4512.4,4161.4,4443.5,0.9469174296539683,-0.07868946541581259,0.21724539949890448,0.6630494116267973,0.44673481150577987,0.3499502041079591,3797]
["High","Q9BTE7","DCN1-like protein 5 [OS=Homo sapiens]",30,6,13,6,237,27.5,5.58,16.27,"protein metabolism;other metabolic processes;stress response;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","DCUN1D5","ENSG00000137692","","Neddylation","",522.4,477.8,493.3,563.1,429.2,465.7,1.0243484224965707,0.03470651798385343,0.7923428511954651,0.10108685608339237,0.8923428504448567,0.049468251623528706,6933]
["High","Q9BTV4","Transmembrane protein 43 [OS=Homo sapiens]",30,13,47,13,400,44.8,8.13,116.42,"cell organization and biogenesis","other membranes;ER/Golgi;nucleus","other molecular function","TMEM43","ENSG00000170876","Envelope proteins and their potential roles in EDMD physiopathology","","",2255.7,2308.8,2351,2088.6,2123.6,2194.3,1.0794505580270037,0.11029716524760481,0.01505861010153528,1.822215111341816,0.10118556598346598,0.9948814347374925,1162]
["High","Q9BTZ2","dehydrogenase/reductase sdr family member 4 [OS=Homo sapiens]",11,2,2,2,278,29.5,8.56,7.68,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","DHRS4","ENSG00000157326; ENSG00000284807","","Peroxisomal protein import; RA biosynthesis pathway","Retinol metabolism; Metabolic pathways; Peroxisome",130.4,121.5,139.9,119,124,123.9,1.0678659035159443,0.09473049301904407,0.2099735559239693,0.6778353968825044,0.4384791454010036,0.3580510573780886,3739]
["High","Q9BUB7","Transmembrane protein 70, mitochondrial [OS=Homo sapiens]",10,2,2,2,260,29,8.91,5.65,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","TMEM70","ENSG00000175606","","","",78.6,98.7,99.5,94.4,117.3,105.1,0.8737373737373739,-0.1947283924428847,0.23369059754997784,0.6313587609253064,0.4652361513692572,0.33232654559843633,3922]
["High","Q9BUI4","DNA-directed RNA polymerase III subunit RPC3 [OS=Homo sapiens]",37,14,21,14,534,60.6,7.31,42.06,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3C","ENSG00000186141","Pyrimidine metabolism; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",794.5,810.2,798,837,860.4,806.7,0.9595064094884388,-0.05963565125326178,0.1061225528359413,0.9741923113732043,0.2935192676383385,0.5323633848614883,2823]
["High","Q9BUP0","EF-hand domain-containing protein D1 [OS=Homo sapiens]",18,4,11,2,239,26.9,5.39,17.37,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","EFHD1","ENSG00000115468","","","",185.5,191.6,179.5,190.7,195.4,217.7,0.9218284200066248,-0.11742984818201761,0.15643826279406575,0.8056570154196013,0.3717194022812128,0.42978476986000885,3286]
["High","Q9BV23","Monoacylglycerol lipase ABHD6 [OS=Homo sapiens]",8,2,2,2,337,38.3,8.41,2.68,"other metabolic processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ABHD6","ENSG00000163686","","Arachidonate production from DAG","Retrograde endocannabinoid signaling",38.3,38.6,28.5,42.2,27.6,44.7,0.9205240174672488,-0.1194727313470919,0.6543468408588929,0.1841919899898551,0.8108459186519975,0.09106166494634647,6301]
["High","Q9BV68-2","Isoform 2 of E3 ubiquitin-protein ligase RNF126 [OS=Homo sapiens]",28,4,9,4,311,33.8,5.47,16.16,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","RNF126","ENSG00000070423; ENSPTRG00000010160","","Antigen processing: Ubiquitination & Proteasome degradation","",253,227.9,248.6,233.6,205.6,211.7,1.1207558764787218,0.16447206391635805,0.08486776330976015,1.0712572435053211,0.2617091216124041,0.5821811401920033,2532]
["High","Q9BVA0","Katanin p80 WD40 repeat-containing subunit B1 [OS=Homo sapiens]",25,13,22,13,655,72.3,7.56,54.32,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KATNB1","ENSG00000140854","Genes related to primary cilium development (based on CRISPR)","","",925.1,916.8,918,948.5,898.3,962.5,0.982415548357242,-0.025594700954129655,0.4494326264155895,0.3473354033055676,0.6677773448245333,0.17536831901119326,5255]
["High","Q9BVG3","E3 ubiquitin-protein ligase TRIM62 [OS=Homo sapiens]",5,2,4,2,475,54.2,6.62,8.74,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","TRIM62","ENSG00000116525","","Interferon gamma signaling","",114.7,106.8,117.1,98.1,109.6,107.4,1.074579498571882,0.10377221887810213,0.17100124263625338,0.767000733654004,0.38824591523811175,0.4108931048173821,3439]
["High","Q9BVJ6-1","U3 small nucleolar RNA-associated protein 14 homolog A [OS=Homo sapiens]",26,19,39,19,771,87.9,7.87,77.94,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","UTP14A","ENSG00000156697","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1426,1543.2,1549.7,1548.9,1342.5,1494.5,1.0303244488018424,0.043098713107992626,0.5798629464159939,0.23667464203848418,0.761191978079368,0.11850579722976534,5948]
["High","Q9BVM4","gamma-glutamylaminecyclotransferase [OS=Homo sapiens]",8,1,2,1,153,17.3,6.87,3.18,"other metabolic processes","cytosol","other molecular function","GGACT","ENSG00000134864","","","",95.7,86.1,92.9,86.5,83.7,93.9,1.0401363120030291,0.05677260890876318,0.4444564346569013,0.3521708018824114,0.6632866670109108,0.1782987325399869,5232]
["High","Q9BVV7","Mitochondrial import inner membrane translocase subunit TIM21 [OS=Homo sapiens]",12,3,4,3,248,28.2,9.7,0,"cell organization and biogenesis;transport","other membranes;mitochondrion","","TIMM21","ENSG00000075336","","Mitochondrial protein import","",78.1,73.5,74,73.2,70.2,74.6,1.034862385321101,0.049438932734504934,0.2639976444870314,0.5783999480955027,0.4999499413424062,0.3010734782382257,4123]
["High","Q9BW71-1","HIRA-interacting protein 3 [OS=Homo sapiens]",11,6,8,6,556,61.9,8.54,20.65,"cell organization and biogenesis","nucleus","","HIRIP3","ENSG00000149929","22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome","","",425.3,428.4,431.1,436.3,388.2,417.6,1.034377264310442,0.04876247006450339,0.36983753179242773,0.43198901793820343,0.6039931914317666,0.21896795697535737,4781]
["High","Q9BWE0","Replication initiator 1 [OS=Homo sapiens]",22,8,13,8,567,63.5,9.98,42.77,"other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","REPIN1","ENSG00000214022","","","",688.7,785,671.6,703.8,648.8,744.6,1.0229353423612437,0.03271495817924818,0.7390832219500137,0.13130665660014387,0.862595186395472,0.0641929697093316,6690]
["High","Q9BWS9-1","Chitinase domain-containing protein 1 [OS=Homo sapiens]",24,7,12,7,393,44.9,8.63,16.38,"other metabolic processes;stress response;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle","other molecular function","CHID1","ENSG00000177830","","Platelet degranulation","",296.7,321.4,308.8,296.6,264.8,291.3,1.0870177084554942,0.1203754433025022,0.1114740525705037,0.952826210076366,0.30127705173779606,0.5210339472619276,2889]
["High","Q9BX66-12","Isoform 12 of Sorbin and SH3 domain-containing protein 1 [OS=Homo sapiens]",5,5,7,5,1294,143.7,8.6,11.95,"","","","SORBS1","","","","",310.7,327.5,325.1,284,283.6,287.5,1.1265349081978715,0.1718920193910594,2.5947794964814794E-3,2.5858995424514357,0.043852896771704314,1.3580017133489257,462]
["High","Q9BXA9","sal-like protein 3 [OS=Homo sapiens]",7,7,7,6,1300,135.3,6.99,16.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SALL3","ENSG00000256463; ENSG00000277015","","","",313,309.7,288.5,332.5,296.8,307.6,0.9725691108976412,-0.04012732303361755,0.5477703241556247,0.261401499655189,0.7388133859055308,0.13146524456335706,5789]
["High","Q9BXF6","Rab11 family-interacting protein 5 [OS=Homo sapiens]",10,5,7,5,653,70.4,9.23,14.76,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB11FIP5","ENSG00000135631","","","Endocytosis",310.1,302.5,275.8,312.1,284.7,299.2,0.9915178571428572,-0.012289339397985648,0.8557489675674981,0.06765361615153317,0.9294321795475067,0.03178229510443276,7189]
["High","Q9BXP5","serrate RNA effector molecule homolog [OS=Homo sapiens]",42,40,132,40,876,100.6,5.96,233.1,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SRRT","ENSG00000087087","","mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes","",5510.7,6098.6,6344.5,6492.4,6135.2,6577.3,0.9348551671708784,-0.09718522270986717,0.21328406899928892,0.6710415824506526,0.4419644402193333,0.35461267191285695,3768]
["Medium","Q9BXT8","Ring finger protein 17 [OS=Homo sapiens]",1,1,4,1,1623,184.5,5.4,0,"other biological processes","nucleus;other cell component","other molecular function","RNF17","ENSG00000132972","","","",132.1,155.7,264.2,147.1,222.9,154.2,1.0530331934376191,0.07455091333711382,0.8542717200550836,0.0684039703516736,0.9289907507228541,0.031988609935338544,7180]
["High","Q9BY11","Protein kinase C and casein kinase substrate in neurons protein 1 [OS=Homo sapiens]",7,3,3,1,444,50.9,5.24,7.13,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","PACSIN1","ENSG00000124507","","Clathrin-mediated endocytosis","",32.8,29.8,17.7,32,22.7,23.5,1.026854219948849,0.038231380209962154,0.9047183601836835,0.04348659610360615,0.9547291466839033,0.02011981876665384,7399]
["High","Q9BY77","Polymerase delta-interacting protein 3 [OS=Homo sapiens]",38,14,32,1,421,46.1,9.99,82.46,"other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","POLDIP3","ENSG00000100227","","mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",1103.6,1088.8,1066.4,1146,1147.9,1095.8,0.96138301324601,-0.05681678228137518,0.09684968255662613,1.013901798425836,0.27955723526881215,0.5535292632097889,2705]
["High","Q9BYD2","39S ribosomal protein L9, mitochondrial [OS=Homo sapiens]",24,6,14,6,267,30.2,10.08,27.86,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL9","ENSG00000143436","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",536.3,546.5,508.5,542.6,530,480.2,1.0247939206594538,0.035333822380338685,0.5938414363531012,0.22632950200496157,0.7707303748412591,0.11309752492991194,6016]
["High","Q9BYG3","MKI67 FHA domain-interacting nucleolar phosphoprotein [OS=Homo sapiens]",41,10,39,10,293,34.2,9.88,97.72,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","NIFK","ENSG00000155438","","","",1820.6,1750.3,1736.2,1861.9,1969.3,1880.2,{"$f":"AVERAGE(T6146:V6146)/AVERAGE(W6146:Y6146)","v":0.9292117519347269},{"$f":"LOG(Z6146,2)","v":-0.10592069456033865},{"$f":"TTEST(T6146:V6146,W6146:Y6146,2,2)","v":0.03313240222842145},{"$f":"-LOG10(AB6146)","v":1.479747074932225},{"$f":"AB6146*7808/AF6146","v":0.15380368406629885},{"$f":"-LOG10(AD6146)","v":0.8130332617354828},1682]
["High","Q9BYK8-1","Helicase with zinc finger domain 2 [OS=Homo sapiens]",12,22,34,22,2649,294.5,7.49,66.93,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HELZ2","ENSG00000130589","","PPARA activates gene expression; Heme signaling; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); Transcriptional activation of mitochondrial biogenesis; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RORA activates gene expression","",746.5,750.8,730.8,626.5,632,662.8,1.1596835475979805,0.2137311789770637,1.3411641165123416E-3,2.872518074844439,0.033349711534166764,1.4769079182590186,314]
["High","Q9BYV8","centrosomal protein of 41 kDa [OS=Homo sapiens]",14,3,6,3,373,41.3,8.32,12.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","cytosol;cytoskeleton;other cell component","","CEP41","ENSG00000106477","Joubert syndrome; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",96.8,98.6,104.9,117.1,125.3,105.8,0.8624353819643882,-0.21351172809395158,0.06064135202852323,1.2172311244607448,0.2162044185564883,0.6651354346422277,2190]
["High","Q9BZ29-4","Isoform 4 of Dedicator of cytokinesis protein 9 [OS=Homo sapiens]",1,2,2,2,2093,238.7,7.62,3.24,"","","","DOCK9","","","","",62.1,58.5,58,50.4,56.4,63.7,1.047507331378299,0.06696034120968788,0.5420898799133196,0.26592870033576194,0.7347053953069257,0.13388677090365325,5761]
["High","Q9BZE2","tRNA pseudouridine(38/39) synthase [OS=Homo sapiens]",9,4,5,4,481,55.6,7.49,12.14,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PUS3","ENSG00000110060","","tRNA modification in the nucleus and cytosol","",279.7,278.6,257.6,286,286,257,0.9841978287092883,-0.022979761221380225,0.735354475737061,0.13350325990115589,0.8606877149685164,0.0651543958951037,6671]
["High","Q9BZH6","WD repeat-containing protein 11 [OS=Homo sapiens]",13,13,29,13,1224,136.6,6.92,55.92,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","WDR11","ENSG00000120008","","RHOH GTPase cycle","",969.3,1125.3,1083.6,977.3,1293.3,1011.6,0.9683139357747851,-0.04645323730665735,0.7692791836334729,0.11391601922666182,0.8793049137476441,0.055860499902831644,6831]
["High","Q9BZK7","F-box-like/WD repeat-containing protein TBL1XR1 [OS=Homo sapiens]",27,9,24,6,514,55.6,5.55,55.77,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1XR1","ENSG00000177565","Rett syndrome causing genes","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Heme signaling; HCMV Early Events; HDACs deacetylate histones; Transcriptional activation of mitochondrial biogenesis; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity","Wnt signaling pathway",702.5,725.1,690.4,777.6,771.4,785.7,0.9071829357090848,-0.14053459173179975,2.7631141713250294E-3,2.558601169751589,0.045324360188457626,1.3436683178134472,476]
["High","Q9BZV1","UBX domain-containing protein 6 [OS=Homo sapiens]",18,4,8,4,441,49.7,6.89,16.25,"protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","","UBXN6","ENSG00000167671","","","Protein processing in endoplasmic reticulum",109.5,109.3,121.5,130.9,132.6,130.3,0.8641442356526154,-0.21065595993654537,0.012081477578971194,1.9178799477387642,0.09027002577665749,1.0444564335272015,1045]
["High","Q9C0B7","Transport and Golgi organization protein 6 homolog [OS=Homo sapiens]",13,9,13,9,1094,120.7,6.11,31.53,"transport","other membranes","","TANGO6","ENSG00000103047","","","",458,423.4,467.9,494,436.9,456.8,0.9723283130359588,-0.040484563347071546,0.5835532836046919,0.23391948285942993,0.7637251153847527,0.1170629272268384,5966]
["High","Q9C0C2","182 kDa tankyrase-1-binding protein [OS=Homo sapiens]",59,72,216,72,1729,181.7,4.86,497.34,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TNKS1BP1","ENSG00000149115","Ciliary landscape","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",7537.9,8465.6,8330.5,8873.8,7626.8,7865.2,0.9986948920207832,-1.8841025556886163E-3,0.9834172035237883,0.00726219859812566,0.9934689513667666,2.8457012373986866E-3,7729]
["High","Q9C0H2-1","Protein tweety homolog 3 [OS=Homo sapiens]",7,4,14,4,523,57.5,5.39,35.23,"transport","plasma membrane;other membranes","transporter activity","TTYH3","ENSG00000136295","","Stimuli-sensing channels","",457.3,439.1,473.2,393.7,371.3,407.6,1.168002728978339,0.2240436450046742,0.010467160865281329,1.9801711012963366,0.08382317131909396,1.0766359123362381,975]
["High","Q9C0J8","pre-mRNA 3' end processing protein WDR33 [OS=Homo sapiens]",18,19,34,19,1336,145.8,9.17,53.9,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","WDR33","ENSG00000136709","","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA surveillance pathway",1134.2,1680.1,1701.9,1813.7,1478,1626,0.9183561420989489,-0.12287434996348626,0.5578194563819319,0.25350634189509025,0.7460524692411996,0.12723062788845046,5838]
["High","Q9GZP9","Derlin-2 [OS=Homo sapiens]",16,2,5,2,239,27.5,7.28,13.02,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","DERL2","ENSG00000072849","","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",75.3,69.5,70.7,72.2,69.8,72.5,1.0046620046620045,0.006710221589552311,0.8734206778256424,0.058776530574431836,0.9390895968689914,0.027292970492669953,7262]
["High","Q9GZT4","serine racemase [OS=Homo sapiens]",9,2,4,2,340,36.5,6.54,5.29,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","SRR","ENSG00000167720","Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; D-Amino acid metabolism; Metabolic pathways",78.7,71.1,76.3,54,52.4,62.1,1.3418397626112761,0.42421240068230837,0.006871385394360014,2.162955692566636,0.06967763267423766,1.1569066130804821,770]
["High","Q9GZU8","Protein FAM192A [OS=Homo sapiens]",27,6,10,6,254,28.9,5.45,17.06,"other biological processes","nucleus","","PSME3IP1","ENSG00000172775","","","",526.2,512.3,510.6,792,523,505.7,0.8508266051518647,-0.23306294814197953,0.3845909993917083,0.4150008838007495,0.6149675452079579,0.2111478034262376,4883]
["High","Q9GZY8-1","Mitochondrial fission factor [OS=Homo sapiens]",28,5,10,5,342,38.4,8.95,19.97,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","C2orf33; MFF","ENSG00000168958","","","",103.9,92,89.3,111.9,106.1,93.2,0.916452442159383,-0.12586807854230384,0.29025846884622347,0.5372151000320191,0.5276689463914582,0.2776384635406448,4295]
["High","Q9H019-1","Mitochondrial fission regulator 1-like [OS=Homo sapiens]",25,5,12,5,292,31.9,6.1,27.63,"cell organization and biogenesis;other metabolic processes","mitochondrion","","FAM54B; MTFR1L","ENSG00000117640; ENSPPAG00000030443","","","",347.6,325,312.7,317.7,261.9,252.2,1.1845395527771099,0.24432637218953726,0.08846017533288052,1.0532522041702694,0.26760831034449095,0.5725004040555028,2581]
["High","Q9H089","Large subunit GTPase 1 homolog [OS=Homo sapiens]",24,14,30,14,658,75.2,6.38,64.71,"transport","cytosol;ER/Golgi;nucleus","other molecular function","LSG1","ENSG00000041802","","","Ribosome biogenesis in eukaryotes",1216.6,1221.2,1243,1234,1249.4,1300.5,0.9727529797299084,-0.03985460042942375,0.18818011870386436,0.7254262618508401,0.41111090286507357,0.38604100536183017,3574]
["High","Q9H0A8-1","COMM domain-containing protein 4 [OS=Homo sapiens]",37,6,8,6,199,21.8,7.31,22.09,"","plasma membrane;other membranes;cytosol;nucleus;other cell component","","COMMD4","ENSG00000140365; ENSGGOG00000014844","","Neddylation","",250.8,273.6,272.1,258.3,386.3,323.5,0.8227455841338707,-0.2814817167954258,0.20360240700296237,0.6912170920429146,0.4302375084923221,0.3662917301151237,3695]
["High","Q9H0G5","Nuclear speckle splicing regulatory protein 1 [OS=Homo sapiens]",20,9,13,9,558,66.4,8.84,21.21,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","NSRP1","ENSG00000126653","","","",594.5,599.6,602.2,708.2,700.9,697.8,0.8525796193459587,-0.2300935263553326,1.1057453523285632E-5,4.956344877382099,0.007194716425817851,2.1429863187710882,12]
["High","Q9H0Q0","Protein FAM49A [OS=Homo sapiens]",18,4,5,4,323,37.3,6.01,9.92,"cell organization and biogenesis","other membranes","other molecular function","CYRIA","ENSG00000197872","","","",109.4,111,115.5,91.7,88.4,84,1.2718667171525935,0.3469474940674053,1.1490831478653226E-3,2.9396485445470733,0.03159169443145225,1.5004270799354755,284]
["High","Q9H0R8-1","Gamma-aminobutyric acid receptor-associated protein-like 1 [OS=Homo sapiens]",13,2,4,1,117,14,8.73,6.43,"cell organization and biogenesis;other metabolic processes;stress response","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","gabarapl1; Gabarapl1; GABARAPL1; gabarapl1.L; GBRL1; LOC101346525; LOC110090845; LOC111142199; LOC113417224; LOC113444478; LOC113982994","ENSACUG00000002920; ENSAMEG00000026339; ENSANAG00000017627; ENSBIXG00000025666; ENSBIXG00005000420; ENSBMUG00000009257; ENSBTAG00000011765; ENSCAFG00000013479; ENSCANG00000037817; ENSCATG00000043779; ENSCCAG00000031173; ENSCGRG00001022681; ENSCGRG00015025519; ENSCHIG00000025179; ENSCJAG00000048408; ENSCPOG00000006718; ENSCPRG00005001116; ENSCSAG00000009078; ENSFCAG00000022695; ENSG00000139112; ENSGAGG00000013450; ENSGALG00000014723; ENSGGOG00000022360; ENSLCNG00005007852; ENSLSDG00000014620; ENSMFAG00000037621; ENSMGAG00000014228; ENSMLEG00000037692; ENSMMUG00000002197; ENSMNEG00000040661; ENSMODG00000018255; ENSMUSG00000030161; ENSNLEG00000029077; ENSNVIG00000010216; ENSOGAG00000000859; ENSPANG00000015789; ENSPCLG00000013759; ENSPPAG00000035460; ENSPSIG00000008179; ENSPTRG00000052409; ENSPTXG00000014934; ENSRBIG00000038034; ENSRFEG00010012750; ENSRNOG00000053362; ENSRROG00000036376; ENSSBOG00000023150; ENSSHBG00005010614; ENSSTOG00000002246; ENSTGUG00000029032; ENSTMTG00000017402; ENSTSYG00000033601; ENSTTRG00000009099; ENSUAMG00000018185; ENSUMAG00000016270; ENSVVUG00000005149; ENSXETG00000016242","Senescence and autophagy in cancer","Macroautophagy; Macroautophagy; Macroautophagy; Macroautophagy; Macroautophagy","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse",125.2,109.1,101.9,114.5,118,103.9,0.9994054696789538,-0.000857981018976564,0.9938177655529474,2.6932440438454525E-3,0.9970100364175014,1.3004698339810917E-3,7783]
["High","Q9H0W5","Coiled-coil domain-containing protein 8 [OS=Homo sapiens]",16,5,6,5,538,59.3,8.63,10.27,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","CCDC8","ENSG00000169515","","Neddylation","",220.5,199.2,208.4,241.5,229.5,219.6,0.9094989863886476,-0.13685606485324653,0.07792345977243396,1.1083317731889935,0.24925291843636396,0.6033597479475467,2441]
["High","Q9H0W9","Ester hydrolase C11orf54 [OS=Homo sapiens]",23,6,12,6,315,35.1,6.7,21.13,"","nucleus","other molecular function","C11orf54","ENSG00000182919","","","",421.3,411.3,404.3,460.7,448.2,438.5,0.9179902033546088,-0.1234493373780597,0.010441857656444913,1.9812222313936299,0.08387862611267684,1.0763486916612688,972]
["High","Q9H1C4","Protein unc-93 homolog B1 [OS=Homo sapiens]",4,2,2,2,597,66.6,6.96,3.23,"stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding","UNC93B1","ENSG00000110057","","Trafficking and processing of endosomal TLR; UNC93B1 deficiency - HSE","",39.7,43.5,42.4,46.4,38.9,42.1,0.9858712715855573,-0.020528813364673344,0.8184834788997232,0.08699008240365695,0.9082886587903694,0.04177610853044519,7036]
["High","Q9H1K0","Rabenosyn-5 [OS=Homo sapiens]",8,6,8,6,784,88.8,5.5,18.35,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RBSN","ENSG00000131381","","Factors involved in megakaryocyte development and platelet production; Toll Like Receptor 9 (TLR9) Cascade","Endocytosis",377.3,444.3,429.1,419.2,415.6,401.2,1.0118932038834951,0.017057034737808202,0.8270592058826084,0.08246339991812697,0.9133915529747393,0.03934300905639094,7070]
["Low","Q9H211","DNA replication factor Cdt1 [OS=Homo sapiens]",1,1,1,1,546,60.4,9.77,1.75,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CDT1","ENSG00000167513","Retinoblastoma gene in cancer; DNA replication","Orc1 removal from chromatin; Activation of the pre-replicative complex; CDT1 association with the CDC6:ORC:origin complex; G1/S-Specific Transcription","",24.4,20.3,24.1,43.1,27.9,33.6,0.6577437858508606,-0.6044023815448432,0.06133501370340147,1.2122915333603752,0.21709147189309097,0.6633572368059116,2206]
["High","Q9H2D6","TRIO and F-actin-binding protein [OS=Homo sapiens]",9,16,28,16,2365,261.2,8.48,54.26,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TRIOBP","ENSG00000100106","","","",960.5,1007.6,957.6,989.8,1023.3,1009.7,0.9678774646023554,-0.047103684164854574,0.16196826370911674,0.7905700733971133,0.3777324381842245,0.42281571805970025,3348]
["High","Q9H2H8-1","peptidyl-prolyl cis-trans isomerase-like 3 [OS=Homo sapiens]",37,7,28,7,161,18.1,6.79,42.36,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","CLK1; LOC111141199; PPIL3","ENSAMEG00000005917; ENSCAFG00000011929; ENSECAG00000019985; ENSFCAG00000005373; ENSG00000240344; ENSGGOG00000022268; ENSOCUG00000010661; ENSPPAG00000039183; ENSPPYG00000013062; ENSPTRG00000012793; ENSRFEG00010017851; ENSSSCG00000016096; ENSSSCG00070023158; ENSSSUG00005004462; ENSSTOG00000028255; ENSUMAG00000021460","mRNA Processing","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","",1078.2,1076.3,1044.9,1111.6,1092.1,1148.1,0.9545318933110568,-0.06713469238334906,0.06095031961926697,1.2150240126293563,0.21661360745891511,0.6643142648912314,2197]
["High","Q9H2S1-1","Small conductance calcium-activated potassium channel protein 2 [OS=Homo sapiens]",2,1,1,1,579,63.7,9.52,2.44,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;cytoskeletal activity;other molecular function","KCNN2","ENSG00000080709","Brain-derived neurotrophic factor (BDNF) signaling pathway","Ca2+ activated K+ channels; Acetylcholine inhibits contraction of outer hair cells","Serotonergic synapse; Insulin secretion; GnRH secretion; Bile secretion",16.1,20.9,18,19.9,16.1,22.6,0.9385665529010238,-0.09146904601022612,0.63589294931302,0.19661599038267824,0.7993965783667784,0.09723771496959355,6211]
["High","Q9H329","Band 4.1-like protein 4B [OS=Homo sapiens]",4,4,14,1,900,99.7,9.04,16,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","EPB41L4B","ENSG00000095203","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway","","Tight junction",177.6,163.1,181.2,250.9,225.5,226.4,0.7426010244735345,-0.4293407893878572,3.8006885232097485E-3,2.420137720555822,0.05346986664724634,1.271890899019863,555]
["High","Q9H3C7","Gametogenetin-binding protein 2 [OS=Homo sapiens]",4,2,2,2,697,79,6.38,3.02,"developmental processes;other biological processes","nucleus;other cell component","","GGNBP2","ENSG00000275099; ENSG00000278311","","","",156,150.7,149,163.5,157.4,148.5,0.9708138048572647,-0.042733471299930575,0.39870359316231735,0.39934985040849763,0.6268783035463903,0.2028167609684077,4966]
["High","Q9H3K6-1","bola-like protein 2 [OS=Homo sapiens]",29,2,4,2,86,10.1,6.52,6.85,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","BOLA2; BOLA2B","ENSG00000169627; ENSG00000183336","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",145.5,131.5,115,153.3,128.1,119.7,0.9773123909249564,-0.03310831181193842,0.8320372083568673,0.07985725180694153,0.9160387088057558,0.038086174077186334,7092]
["High","Q9H3P2-1","Negative elongation factor A [OS=Homo sapiens]",39,14,43,14,528,57.2,9.03,96.4,"developmental processes;other biological processes","cytosol;nucleus","other molecular function","NELFA","ENSG00000185049","Initiation of transcription and translation elongation at the HIV-1 LTR","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1648.8,1555.6,1524.9,1693.2,1513.6,1581.3,0.9877195547294332,-0.01782662234328658,0.7755883979480731,0.11036869616994067,0.8827688354487689,0.054153007218056944,6860]
["High","Q9H3Z4","DnaJ homolog subfamily C member 5 [OS=Homo sapiens]",20,4,12,4,198,22.1,5.07,29.22,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","DNAJC5","ENSG00000101152","","Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; GABA synthesis, release, reuptake and degradation","Protein processing in endoplasmic reticulum",624.7,643.6,682,555.3,576.7,558.6,1.1536141015024253,0.20616070495773617,0.008796102401522586,2.055709723358845,0.07849139148695812,1.105177971722523,875]
["High","Q9H479","fructosamine-3-kinase [OS=Homo sapiens]",15,5,7,5,309,35.1,7.55,16.94,"protein metabolism;other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","FN3K","ENSG00000167363","","Gamma carboxylation, hypusine formation and arylsulfatase activation","",263.9,275.2,248.5,281.6,240.7,268.6,0.995827538247566,-0.006032183175041506,0.9425120659734196,0.025713081279058074,0.9734304512064101,0.011695072121629197,7560]
["High","Q9H4B6","Protein salvador homolog 1 [OS=Homo sapiens]",20,6,10,6,383,44.6,9.09,16.57,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SAV1","ENSG00000151748","Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma","Signaling by Hippo","Hippo signaling pathway; Hippo signaling pathway",283.7,305.6,301.6,288.7,263.1,264.1,1.0919230297830615,0.1268711635251875,0.080513873384952,1.0941292796892343,0.2538983535499617,0.5953401153786794,2476]
["High","Q9H4G0-1","Band 4.1-like protein 1 [OS=Homo sapiens]",19,13,26,12,881,98.4,5.62,53.71,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","EPB41L1","ENSG00000088367","Splicing factor NOVA regulated synaptic proteins","Trafficking of AMPA receptors; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Neurexins and neuroligins","",651.5,663.7,610,680.7,656.8,679.9,0.9542976107861604,-0.06748883426747937,0.16372284669673934,0.7858907127566881,0.3795570032684503,0.4207229909256646,3368]
["High","Q9H4M3-2","Isoform 2 of F-box only protein 44 [OS=Homo sapiens]",13,2,2,2,224,25.7,7.88,5.88,"","","","FBXO44","","","","",64.9,49.4,55.1,55.3,45.5,55.2,1.085897435897436,0.11888784558258812,0.4677118452095374,0.33002163106648735,0.682597025681508,0.16583560842908043,5350]
["High","Q9H501","ESF1 homolog [OS=Homo sapiens]",25,19,44,19,851,98.7,5.11,98.45,"RNA metabolism OR transcription;other metabolic processes","nucleus","","ESF1","ENSG00000089048","","","",2251.7,2435.8,2438.4,2699.4,2509.8,2605.6,0.9118467523161179,-0.1331367137550412,0.04974085517810724,1.3032867523201976,0.19389745243667567,0.7124278969551384,2003]
["High","Q9H5L6","DNA transposase THAP9 [OS=Homo sapiens]",2,2,2,2,903,103.3,9.13,3.01,"DNA metabolism;other metabolic processes","","nucleic acid binding activity;other molecular function","THAP9","ENSG00000168152","","","",71.3,59.8,58.5,43.6,42.7,54,1.351389878831076,0.4344439552783598,0.03932262858609645,1.4053574587371394,0.16814407667044964,0.774318427276784,1826]
["High","Q9H6A9-1","Pecanex-like protein 3 [OS=Homo sapiens]",3,3,4,3,2034,221.9,6.64,8.04,"","other membranes","","PCNX3","ENSG00000197136","","","",279.7,268.4,280.4,234.1,237.6,240,1.1641140930167202,0.219232461479009,7.8770363231700047E-4,3.1036371518753674,0.026857598083542093,1.5709328295566198,229]
["High","Q9H6E4","Coiled-coil domain-containing protein 134 [OS=Homo sapiens]",20,4,12,4,229,26.5,8.85,30.41,"developmental processes","non-structural extracellular;ER/Golgi;nucleus","","CCDC134","ENSG00000100147","","","",445.5,470.4,447.3,411.5,453.8,418.7,1.0616822429906543,0.08635203821617288,0.1601473118361401,0.7954803468192599,0.37595616681196087,0.424862787044125,3326]
["High","Q9H6S0","Probable ATP-dependent RNA helicase YTHDC2 [OS=Homo sapiens]",7,6,9,6,1430,160.1,8.4,14.29,"cell cycle OR cell proliferation;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","YTHDC2","ENSG00000047188","","","",250.6,276.2,248.9,291.2,313.2,289.3,0.8679646413785386,-0.20429182266330256,0.02822734934766316,1.5493299017939557,0.14191831532939728,0.8479615528638788,1553]
["High","Q9H6S3","epidermal growth factor receptor kinase substrate 8-like protein 2 [OS=Homo sapiens]",6,4,4,4,715,80.6,6.84,8.54,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","cytoskeletal activity","EPS8L2","ENSG00000177106","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",175.5,194.2,198.4,252.3,211.3,236.5,0.8114555063562349,-0.30141610364958005,0.033703329890541325,1.472327188694089,0.15507106646160676,0.8094692263531293,1697]
["High","Q9H6Z4-2","Isoform 2 of Ran-binding protein 3 [OS=Homo sapiens]",36,14,47,14,562,59.7,4.81,105.84,"","","","RANBP3","","","","",1746.2,1734.7,1630.8,1847.5,1762.9,1672.9,0.967520299812617,-0.04763616372668864,0.41087682223537475,0.3862883568135426,0.6372916622991271,0.1956617633672511,5034]
["High","Q9H7H0","Methyltransferase-like protein 17, mitochondrial [OS=Homo sapiens]",5,2,2,2,456,50.7,9.33,5.01,"protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus","other molecular function","METTL17","ENSG00000165792","","","",54.8,60.2,58.3,64.9,67.5,66.1,0.8730478589420655,-0.19586735287015047,8.663276734904907E-3,2.06231781251747,0.07801945184098906,1.1077971053350446,867]
["High","Q9H7L9","Sin3 histone deacetylase corepressor complex component SDS3 [OS=Homo sapiens]",16,5,8,5,328,38.1,5.66,18.91,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","SUDS3","ENSG00000111707","","Ub-specific processing proteases; NoRC negatively regulates rRNA expression; HDACs deacetylate histones; Potential therapeutics for SARS","",232.9,204.8,195.7,268.5,218.9,202.2,0.9185034802784224,-0.12264290706090794,0.45818793453604245,0.33895635127366136,0.6750059231806452,0.17069241621581496,5300]
["Medium","Q9H816","5' exonuclease Apollo [OS=Homo sapiens]",2,1,1,1,532,60,8.41,0,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DCLRE1B","ENSG00000118655","","Fanconi Anemia Pathway","",79.6,84.4,81.2,80.2,80.1,84.7,1.0008163265306123,1.1772298008486091E-3,0.9758712272284278,0.010607486630245593,0.9881471329528678,0.005178385096493911,7711]
["High","Q9H8E8-1","Cysteine-rich protein 2-binding protein [OS=Homo sapiens]",9,6,6,6,782,88.8,6.57,14.23,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","KAT14","ENSG00000149474","","HATs acetylate histones","",269.5,273.3,255,241.2,283.6,247.6,1.0328845157949251,0.04667895913651329,0.5863037201953105,0.23187735013522806,0.7651444839186001,0.11625654831863909,5983]
["High","Q9H8G2-1","Caspase activity and apoptosis inhibitor 1 [OS=Homo sapiens]",25,6,14,6,361,38.3,4.72,35.38,"other biological processes","","","CAAP1","ENSG00000120159","Acute viral myocarditis","","",350.2,351.3,361.6,362.4,370.2,383.9,0.9521719659650693,-0.0707059414799347,0.0702414772246207,1.1534063635063512,0.2338786584946006,0.6310094058988177,2345]
["Medium","Q9H8M1","Coenzyme Q-binding protein COQ10 homolog B, mitochondrial [OS=Homo sapiens]",3,1,1,1,238,27.1,9.6,2.33,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ10B","ENSG00000115520","","Respiratory electron transport","",90.8,102.3,99.4,97.4,96.3,95.5,1.011410788381743,0.01636907240701168,0.7688022721312711,0.11418534181633856,0.8790171534340262,0.056002649876108195,6829]
["High","Q9H900-1","Protein zwilch homolog [OS=Homo sapiens]",25,11,21,11,591,67.2,6.27,32.56,"cell cycle OR cell proliferation;signal transduction;other biological processes","cytosol;other cell component","","ZWILCH","ENSG00000174442","","RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",772.1,780.7,786.8,789.5,839.8,784.8,0.9691396379603167,-0.045223544335855514,0.24222425313348295,0.6157823745096258,0.4737692806779145,0.3244331024663239,3992]
["High","Q9H920","RING finger protein 121 [OS=Homo sapiens]",5,1,1,1,327,37.9,7.06,3.13,"protein metabolism;other metabolic processes;stress response;signal transduction","other membranes;ER/Golgi","other molecular function","RNF121","ENSG00000137522","","","",18.1,16.6,16.8,15.6,19.6,23.4,0.878839590443686,-0.1863282323516672,0.361726492221326,0.44161968309846805,0.5976217628574088,0.22357359573618282,4726]
["High","Q9H9B1","histone-lysine N-methyltransferase EHMT1 [OS=Homo sapiens]",28,24,47,23,1298,141.4,5.76,99.5,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","EHMT1","ENSG00000181090","Histone modifications; MTHFR deficiency","Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; Senescence-Associated Secretory Phenotype (SASP); Regulation of TP53 Activity through Methylation; Transcriptional Regulation by VENTX","Lysine degradation; Metabolic pathways; Longevity regulating pathway",1509,1493.7,1533.8,1577.5,1467.8,1601.3,0.9763052554556019,-0.03459579783925869,0.4389225461933609,0.35761211011908506,0.6589323669828422,0.18115915923528175,5201]
["High","Q9H9C1-1","Spermatogenesis-defective protein 39 homolog [OS=Homo sapiens]",31,13,18,13,493,57,7.4,40.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","C14orf133; VIPAS39","ENSG00000151445; ENSPTRG00000006581","","","",772.2,766.2,773.8,748.3,721.8,696.6,1.0671528130336456,0.0937667804925003,0.03255751914821456,1.487348695345766,0.15240354287125854,0.8170049369888506,1668]
["High","Q9H9J4-2","Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 42 [OS=Homo sapiens]",10,10,15,10,1316,144.2,8.47,24.71,"","","","USP42","","","","",540,519.8,525.2,544.3,498.7,527.3,1.0093612685474116,0.013442633371091561,0.7541985362803878,0.12251431479166551,0.8712505061809835,0.05985695657652339,6759]
["High","Q9H9Z2","Protein lin-28 homolog A [OS=Homo sapiens]",66,13,106,11,209,22.7,8.07,240.43,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","LIN28A","ENSG00000131914","Cardiac progenitor differentiation; CCL18 signaling pathway","Transcriptional regulation of pluripotent stem cells","",4294.9,4207.7,4051.3,4075.2,4508.2,4277.4,0.9761367877581485,-0.03484476554932612,0.5165657149320907,0.2868744218365711,0.718828212830113,0.14337488588139286,5611]
["Medium","Q9HAB3","Solute carrier family 52, riboflavin transporter, member 2 [OS=Homo sapiens]",2,1,1,1,445,45.7,7.15,1.63,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC52A2","ENSG00000185803; ENSG00000285112","","Vitamin B2 (riboflavin) metabolism","",60.4,53,55.5,47.8,38.5,40.9,1.3278301886792454,0.40907065751703053,0.017066172176055827,1.767863877200171,0.10913404778922514,0.9620397364864179,1221]
["High","Q9HAS0","Protein Njmu-R1 [OS=Homo sapiens]",26,6,7,6,396,44.6,5.03,15.59,"cell organization and biogenesis;transport","ER/Golgi;other cell component","","C17orf75","ENSG00000108666","","","",192.7,191.7,207.5,216.6,208.5,210.5,0.9312460667086216,-0.10276566790380443,0.061721841900643275,1.20956112221761,0.21737669894462006,0.6627870106734627,2217]
["High","Q9HAV7","GrpE protein homolog 1, mitochondrial [OS=Homo sapiens]",41,10,16,10,217,24.3,8.12,27.2,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","GRPEL1","ENSG00000109519","","Mitochondrial protein import","",1211.6,989.9,799.8,1081.8,757.8,729.9,1.1680482584160343,0.22409988101522385,0.42983475088814904,0.36669847598075284,0.6507949844744363,0.18655580272883224,5157]
["High","Q9HB09-1","Bcl-2-like protein 12 [OS=Homo sapiens]",17,5,8,5,334,36.8,9.22,16.21,"other biological processes","nucleus","","BCL2L12","ENSG00000126453","Regulation of apoptosis by parathyroid hormone-related protein","","",398.7,371.4,363.4,297,290.4,283.3,1.3018261169174226,0.38053676262512365,0.001539774014771604,2.8125430137995133,0.035675238894174136,1.4476331100122164,337]
["High","Q9HBE1-1","POZ-, AT hook-, and zinc finger-containing protein 1 [OS=Homo sapiens]",5,3,8,2,687,74,8.35,21.19,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PATZ1; ZNF278","ENSANAG00000029603; ENSCCAG00000028772; ENSCJAG00000010978; ENSG00000100105; ENSSBOG00000003894","Androgen receptor signaling pathway","","",118.7,124.1,137.1,135.7,139.9,127.1,0.9433821703501364,-0.08408576028073197,0.31583122470626096,0.5005449356093433,0.5526692520184863,0.2575346968985268,4462]
["High","Q9HBL8","NmrA-like family domain-containing protein 1 [OS=Homo sapiens]",10,3,7,3,299,33.3,7.52,12.91,"","cytosol;nucleus;other cell component","other molecular function","NMRAL1","ENSG00000153406; ENSG00000274684","","Urea cycle","",301.8,304.5,338.6,316.3,321.8,302.9,1.004144527098831,0.005966932159861579,0.9257533047508757,0.03350472893284589,0.964671266981828,0.015620656872311537,7493]
["High","Q9HC07","Transmembrane protein 165 [OS=Homo sapiens]",22,4,12,4,324,34.9,7.02,39.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","TMEM165","ENSG00000134851","IL-18 signaling pathway","","",409.8,376.5,396.6,402.2,407.6,429.2,0.9547215496368039,-0.06684807119899122,0.21544195249819667,0.6666697236730856,0.4444308494335323,0.35219580285054175,3785]
["Low","Q9HC96","Calpain-10 [OS=Homo sapiens]",1,1,1,1,672,74.9,7.74,1.79,"cell organization and biogenesis;protein metabolism;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","CAPN10","ENSG00000142330","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",52.1,46,50.7,54.7,54,55.1,0.9084249084249084,-0.13856083053297727,0.05580188138803559,1.2533511583622787,0.2075755549679761,0.6828237922860438,2099]
["High","Q9HCE3","Zinc finger protein 532 [OS=Homo sapiens]",16,15,26,14,1301,141.6,8.65,48.84,"","nucleus","nucleic acid binding activity;other molecular function","ZNF532","ENSG00000074657","","","",733.6,745.8,761.5,983,960.3,959,0.7721117734210798,-0.37311838303152667,3.9588223861048494E-5,4.402433982578417,0.010303495063568889,1.9870154326394438,30]
["High","Q9HCJ3","Ribonucleoprotein PTB-binding 2 [OS=Homo sapiens]",3,2,3,2,691,74.3,7.47,2.09,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RAVER2","ENSG00000162437","","","",133.1,138.2,124.7,130.8,201,199.4,0.7454819277108431,-0.4237547163799534,0.1272483300332587,0.8953479084968988,0.32779774361586406,0.48439404020588567,3031]
["High","Q9HCP0-1","Casein kinase I isoform gamma-1 [OS=Homo sapiens]",11,4,5,2,422,48.5,9.01,8.29,"cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK1G1","ENSG00000169118; ENSMFAG00000002355; ENSMMUG00000021124; ENSMNEG00000044820; ENSPPYG00000006548; ENSRROG00000038647","Wnt signaling pathway; Hedgehog signaling pathway","","Hedgehog signaling pathway",34.6,30.8,33.3,29.5,36.8,32.2,{"$f":"AVERAGE(T6594:V6594)/AVERAGE(W6594:Y6594)","v":1.0020304568527918},{"$f":"LOG(Z6594,2)","v":0.002926360112658927},{"$f":"TTEST(T6594:V6594,W6594:Y6594,2,2)","v":0.979214060094213},{"$f":"-LOG10(AB6594)","v":0.009122359314636085},{"$f":"AB6594*7808/AF6594","v":0.9901195779870001},{"$f":"-LOG10(AD6594)","v":0.004312351944030997},7722]
["High","Q9HD20","manganese-transporting ATPase 13A1 [OS=Homo sapiens]",16,17,38,17,1204,132.9,8.13,79.63,"transport;other biological processes","other membranes;ER/Golgi","transporter activity;other molecular function","ATP13A1","ENSG00000105726","","Ion transport by P-type ATPases","",1476.4,1473.9,1481,1321.7,1324.2,1410.3,1.092475716187565,0.12760121151063825,0.012827251551720027,1.891866388347648,0.09273627788502774,1.0327503391759625,1080]
["High","Q9HD42-1","Charged multivesicular body protein 1a [OS=Homo sapiens]",16,5,10,5,196,21.7,8.06,18.52,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CHMP1A","ENSG00000131165; ENSPPAG00000031215; ENSPPYG00000007667","","HCMV Late Events","Endocytosis; Necroptosis",559.5,580.6,526.9,603.8,538.7,552.3,0.983596884588152,-0.02386092949011111,0.7321101699292815,0.13542356020914167,0.859337974565218,0.06583599609798788,6652]
["High","Q9NNW7-1","thioredoxin reductase 2, mitochondrial [OS=Homo sapiens]",19,6,8,5,524,56.5,7.5,22.01,"stress response;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","TXNRD2","ENSG00000184470","Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Oxidative stress response; 22q11.2 copy number variation syndrome","Detoxification of Reactive Oxygen Species","Selenocompound metabolism; Pathways in cancer; Hepatocellular carcinoma",237.2,243.3,238.8,239.6,239.7,254.4,0.980373449638817,-0.02859668105498953,0.4118782938516003,0.3852310949308576,0.6380844679351776,0.1951218267177475,5040]
["High","Q9NP73-1","Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 [OS=Homo sapiens]",8,6,6,6,1137,126,6.74,8.65,"protein metabolism","other membranes;ER/Golgi","other molecular function","ALG13","ENSG00000101901","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG14 causes ALG14-CMS","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways",71.3,78.1,68.7,87,131.7,104.5,0.6748143564356435,-0.5674374281110445,0.05797596155390572,1.2367520396870897,0.2114321848729079,0.6748289023228926,2141]
["Medium","Q9NP87","DNA-directed DNA/RNA polymerase mu [OS=Homo sapiens]",2,1,1,1,494,54.8,8.41,2.27,"DNA metabolism;other metabolic processes;stress response","nucleus","nucleic acid binding activity;other molecular function","POLM","ENSG00000122678","Non-homologous end joining; DNA repair pathways, full network","Nonhomologous End-Joining (NHEJ)","Non-homologous end-joining",22.9,27.6,26.1,20.1,34.3,24,0.9770408163265304,-0.03350926219025146,0.8994080136481064,0.04604324722432777,0.9522139349917851,0.021265467215892963,7375]
["Medium","Q9NPE2-2","Neugrin [OS=Homo sapiens]",3,1,1,1,291,32.4,9.1,2.4,"developmental processes;other biological processes","non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus","nucleic acid binding activity","NGRN","ENSG00000182768","","","",17.7,38.8,30.1,35,29.9,27.4,0.9382448537378113,-0.0919636229190496,0.7851553567620821,0.10504440196947497,0.8873198763349742,0.05191978999473317,6909]
["High","Q9NPH2","Inositol-3-phosphate synthase 1 [OS=Homo sapiens]",24,12,52,12,558,61,5.76,130.48,"other metabolic processes","cytosol;other cell component","other molecular function","ISYNA1","ENSG00000105655","","Synthesis of IP2, IP, and Ins in the cytosol","Inositol phosphate metabolism; Metabolic pathways",1780.2,1700.8,1677.5,1564.4,1532.6,1571.4,1.104982435095536,0.14402343658324734,0.008010085027109684,2.096362873852272,0.07571760761703682,1.1208031165140189,826]
["High","Q9NPJ8","NTF2-related export protein 2 [OS=Homo sapiens]",21,3,6,1,142,16.2,5.48,4.31,"transport","cytosol;nucleus;other cell component","","NXT2","ENSG00000101888","","","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; mRNA surveillance pathway; Amyotrophic lateral sclerosis; Influenza A",114.1,120.1,121,112.9,116.2,101.7,1.0737605804111245,0.10267234717883128,0.17182073904372897,0.7649244172879041,0.38920114025339014,0.40982589603721625,3447]
["High","Q9NQ66-1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [OS=Homo sapiens]",4,3,3,3,1216,138.5,6.23,2.5,"cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PLCB1","ENSG00000182621; ENSPPAG00000023075; ENSPTRG00000013241","AMP-activated protein kinase (AMPK) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; S1P receptor signal transduction; Cell-type dependent selectivity of CCK2R signaling; Chemokine signaling pathway; GPR40 pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; Fragile X syndrome; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; Alzheimer's disease","Ca2+ pathway; Synthesis of IP3 and IP4 in the cytosol; G alpha (q) signalling events; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion","Inositol phosphate metabolism; Metabolic pathways; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; Chemokine signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Apelin signaling pathway; Gap junction; Platelet activation; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Alzheimer disease; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis; Chagas disease; African trypanosomiasis; Amoebiasis; Human cytomegalovirus infection; Pathways in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis",10.4,15.4,12.2,13.1,12.1,12.8,1,0,1,0,1.0002562131693569,-1.11257713405497E-4,7806]
["High","Q9NQC3","Reticulon-4 [OS=Homo sapiens]",46,30,150,22,1192,129.9,4.5,322.61,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","RTN4","ENSG00000115310","Alzheimer's disease and miRNA effects; Spinal cord injury; 22q11.2 copy number variation syndrome; Alzheimer's disease","Axonal growth inhibition (RHOA activation)","Alzheimer disease",2989.5,3046.4,2983,3013.1,2776.6,2854.9,1.0432987067070771,0.061152274815993106,0.1599970166444954,0.7958881152622798,0.37571630254442706,0.4251399602427678,3325]
["High","Q9NQG6","Mitochondrial dynamics protein MID51 [OS=Homo sapiens]",8,4,5,4,463,51.3,7.64,8.82,"cell organization and biogenesis;stress response;other biological processes","other membranes;mitochondrion","other molecular function","MIEF1","ENSG00000100335","","","",236.5,229.3,227.2,242.6,213.9,227.6,1.0130097938897822,0.018648122340350532,0.751711276835631,0.12394893461388509,0.8696638982860582,0.06064855809663871,6749]
["High","Q9NQT5","exosome complex component RRP40 [OS=Homo sapiens]",36,5,15,5,275,29.6,8.1,39.12,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","EXOSC3","ENSG00000107371","","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","RNA degradation",446.6,480.1,458.3,473.8,501,448.6,0.9730223408739638,-0.03945516480589173,0.5170645757520281,0.2864552148529698,0.7190098321410215,0.14326517079181095,5615]
["High","Q9NQY0-1","Bridging integrator 3 [OS=Homo sapiens]",16,3,3,3,253,29.6,7.47,8.77,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","other molecular function","BIN3","ENSG00000147439; ENSGGOG00000002428; ENSPPAG00000028325; ENSPTRG00000020066","","","",219.4,199.1,170.2,187.7,189.7,196.4,1.0259672359707217,0.036984659544084225,0.7494480902863767,0.12525844271284944,0.8676884176981065,0.061636199670899915,6744]
["High","Q9NR19-1","Acetyl-coenzyme A synthetase, cytoplasmic [OS=Homo sapiens]",5,4,9,3,701,78.5,6.46,19.43,"other metabolic processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","ACSS2","ENSG00000131069","Fatty acid beta-oxidation; Fatty acid biosynthesis; Lipid metabolism pathway; Ethanol effects on histone modifications; Fluoroacetic acid toxicity; Amino acid conjugation of benzoic acid","Transcriptional activation of mitochondrial biogenesis; Ethanol oxidation","Glycolysis / Gluconeogenesis; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism",350.3,373.8,375.9,395.1,384.7,408.8,0.9254585226316676,-0.11175976231125814,0.051817200871578664,1.2855260509962978,0.19871743831300895,0.7017640200023836,2036]
["High","Q9NR45","sialic acid synthase [OS=Homo sapiens]",49,13,69,13,359,40.3,6.74,117.51,"other metabolic processes","cytosol;other cell component","other molecular function","NANS","ENSG00000095380","","Sialic acid metabolism","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars",1892.7,1940.2,1968.5,1803.6,1802.8,1853.1,1.062624782489239,0.08763226478735249,0.01463131996737741,1.8347164921460912,0.09986131670042205,1.0006027119444612,1144]
["High","Q9NRF8","CTP synthase 2 [OS=Homo sapiens]",37,19,50,15,586,65.6,6.9,98.28,"other metabolic processes","cytosol;other cell component","other molecular function","CTPS2","ENSG00000047230","Pyrimidine metabolism","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism; Metabolic pathways; Biosynthesis of cofactors",1809,1893,1871.2,1878,2064.6,2035,0.9323474304068522,-0.10106043322349499,0.09962791912043928,1.0016189404834015,0.2835927059760809,0.5473049434292956,2743]
["High","Q9NRG9-1","Aladin [OS=Homo sapiens]",37,14,30,14,546,59.5,7.5,74.13,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus","","AAAS","ENSG00000094914","","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; RHOA GTPase cycle; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; Regulation of HSF1-mediated heat shock response; Vpr-mediated nuclear import of PICs; Viral Messenger RNA Synthesis; tRNA processing in the nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Ribonucleoproteins into the Host Nucleus; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)","Nucleocytoplasmic transport",1195.7,1135.3,1218.2,1093.8,1229.3,1172.7,1.0152754734252531,0.021871225167431046,0.720989739565939,0.14207091569888106,0.8516623126370426,0.06973257052588591,6610]
["High","Q9NRN9","Methyltransferase-like protein 5 [OS=Homo sapiens]",16,2,7,2,209,23.7,6.68,4.94,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","METTL5","ENSG00000138382","","","",28.4,35.2,33.9,30.6,50.4,42.7,0.788197251414713,-0.3433713763393968,0.22723512637488927,0.6435245338252933,0.45881868806184,0.33835890123972334,3867]
["High","Q9NRV9","Heme-binding protein 1 [OS=Homo sapiens]",66,11,41,11,189,21.1,5.8,79.41,"other biological processes","non-structural extracellular;other cell component","other molecular function","HEBP1","ENSG00000013583","","G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands","",1966.3,2018.5,1937.1,1773.3,1827.1,1773.1,1.1020563878291614,0.1401980427477941,3.591633531376062E-3,2.4447079825338296,0.0517407280682367,1.2861674644135812,542]
["High","Q9NRX2","39S ribosomal protein L17, mitochondrial [OS=Homo sapiens]",9,2,3,2,175,20,10.11,7.03,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL17","ENSG00000158042","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",339.3,281.8,229,301.9,240,240.9,1.0859734287174247,0.11898880413069689,0.5854560857317295,0.23250567521098772,0.7649332525758606,0.11637645935969473,5976]
["High","Q9NS69","Mitochondrial import receptor subunit TOM22 homolog [OS=Homo sapiens]",51,4,34,4,142,15.5,4.34,103.23,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity","TOMM22","ENSG00000100216","","PINK1-PRKN Mediated Mitophagy; Mitochondrial protein import","",1060.3,1041,1075,991.5,1037.9,1031,1.0378708665533918,0.05362695258555511,0.09172389692498617,1.0375175023822867,0.27241543826180753,0.564768283830014,2629]
["High","Q9NS91","E3 ubiquitin-protein ligase RAD18 [OS=Homo sapiens]",16,6,13,6,495,56.2,7.58,36.28,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD18","ENSG00000070950","SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome","Recognition of DNA damage by PCNA-containing replication complex; E3 ubiquitin ligases ubiquitinate target proteins","",750,765.3,803.7,777.2,848.4,820.3,0.9481172574512451,-0.0768626008669676,0.18106235652560387,0.7421718315883769,0.40208614327415104,0.3956808933314757,3516]
["High","Q9NSG2-1","Uncharacterized protein C1orf112 [OS=Homo sapiens]",3,2,4,2,853,96.5,6,2.5,"","","","C1orf112","ENSG00000000460","","","",81,80.8,73.4,83.5,83.5,99.5,0.8825515947467168,-0.18024747281017356,0.15122445741332016,0.8203779650472524,0.3642074532644059,0.43865117090111305,3242]
["High","Q9NSV4-3","Protein diaphanous homolog 3 [OS=Homo sapiens]",9,8,12,8,1193,136.8,7.03,20.5,"cell organization and biogenesis","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","DIAPH3","ENSG00000139734","Regulation of actin cytoskeleton","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; RHOC GTPase cycle; RHO GTPases Activate Formins; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","Regulation of actin cytoskeleton",300.9,297,313.3,282.5,299.9,297,1.0361610188765067,0.05124821449546463,0.21950832816593518,0.6585489979371362,0.4493762523124336,0.3473898819884876,3814]
["High","Q9NTK5-1","obg-like ATPase 1 [OS=Homo sapiens]",71,23,115,10,396,44.7,7.81,241.2,"other metabolic processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","translation activity;other molecular function","LOC111144733; Ola1; OLA1","ENSCCAG00000017844; ENSFCAG00000036661; ENSG00000138430; ENSLCNG00005010543; ENSMMUG00000007092; ENSMNEG00000040767; ENSMPUG00000013906; ENSNVIG00000008347; ENSPTRG00000012650; ENSRROG00000038551","","Platelet degranulation","",6299,6342.7,6451.9,6522.4,6300.6,6383.2,0.994137309827035,-0.008482964905216954,0.659863209559389,0.18054608489860863,0.8134215251404656,0.0896843392758664,6334]
["High","Q9NTX7","E3 ubiquitin-protein ligase rnf146 [OS=Homo sapiens]",11,3,3,3,359,38.9,5.33,7.74,"cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RNF146","ENSG00000118518","","Ub-specific processing proteases; Degradation of AXIN; Regulation of PTEN stability and activity","",182.8,187.6,189,151.9,167.6,155,1.1789251844046365,0.23747216656771994,0.005363221453289967,2.270574270171707,0.06176406063021837,1.2092641593801352,678]
["High","Q9NUI1","Peroxisomal 2,4-dienoyl-CoA reductase [OS=Homo sapiens]",12,3,4,3,292,30.8,9.22,10.7,"other metabolic processes","other membranes;cytosol;other cytoplasmic organelle","other molecular function","DECR2","ENSG00000242612; ENSG00000274296","","Peroxisomal protein import; Beta-oxidation of very long chain fatty acids","Peroxisome",194.7,200.1,183.2,161.7,178.7,183.2,1.103896103896104,0.14260439544280046,0.09224783051834966,1.0350438387731133,0.27345142774763637,0.5631198047402429,2634]
["High","Q9NUQ3-1","Gamma-taxilin [OS=Homo sapiens]",35,16,29,16,528,60.5,7.52,53.28,"cell cycle OR cell proliferation;other biological processes","other membranes;cytosol;nucleus","other molecular function","TXLNG","ENSG00000086712","","","",838.9,885.5,818.4,954.4,869.7,834.6,0.9564072667092941,-0.06430300330955385,0.3965134485938067,0.40174207807896384,0.6255762793737003,0.20371972723148465,4949]
["High","Q9NUQ6","SPATS2-like protein [OS=Homo sapiens]",4,3,4,3,558,61.7,9.64,2.15,"","cytosol;nucleus;other cell component","","SPATS2L","ENSG00000196141","","","",234,201.3,210,300.5,317.1,308.9,0.696492174851592,-0.5218209507704111,1.0010572184069473E-3,2.999541098416576,0.029947336250273734,1.5236418010962216,261]
["High","Q9NUY8","TBC1 domain family member 23 [OS=Homo sapiens]",14,7,14,7,699,78.3,5.41,30.47,"cell organization and biogenesis;transport;developmental processes","cytosol;ER/Golgi;other cell component","","TBC1D23","ENSG00000036054","","","",226.6,242.2,262.8,267,301,279.7,0.8630411702253155,-0.21249871200321657,0.05514130083891316,1.2585229926644501,0.20669384395114446,0.6846724579535606,2083]
["High","Q9NVA2-1","Septin-11 [OS=Homo sapiens]",40,17,85,7,429,49.4,6.81,191.24,"cell cycle OR cell proliferation;other biological processes","cytoskeleton;other cell component","other molecular function","Sept11; SEPT11; SEPTIN11","ENSANAG00000029750; ENSBTAG00000021372; ENSCATG00000027299; ENSCCAG00000022420; ENSCHIG00000021075; ENSCSAG00000004591; ENSFCAG00000027412; ENSG00000138758; ENSLCNG00005000771; ENSMFAG00000042066; ENSMMUG00000019901; ENSMNEG00000044831; ENSNLEG00000032040; ENSPCTG00005005661; ENSPPAG00000041700; ENSPTRG00000016192; ENSRBIG00000024343; ENSRROG00000038768; ENSSBOG00000020488; ENSSSUG00005020042; ENSUAMG00000017287","22q11.2 copy number variation syndrome","","Bacterial invasion of epithelial cells; Shigellosis",5056.1,5129.8,5111.2,5311.2,5342.6,5431.1,0.9510223874565588,-0.07244879176956233,3.3864124312228717E-3,2.470260150274187,0.050556612357529986,1.2962220344828257,523]
["High","Q9NVF7-1","F-box only protein 28 [OS=Homo sapiens]",24,8,10,8,368,41.1,9.55,27.6,"protein metabolism;other metabolic processes","other cell component","other molecular function","FBXO28","ENSG00000143756; ENSGGOG00000010974; ENSPPAG00000034613; ENSPTRG00000002021","","","",425.1,438.3,473.3,396.3,359.6,395.8,1.1606321090561778,0.21491074692423523,0.03063084508236821,1.5138410211644886,0.1484578761037436,0.8283967569250714,1611]
["High","Q9NVI1-3","Fanconi anemia group I protein [OS=Homo sapiens]",30,35,82,35,1328,149.2,6.74,164.89,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","FANCI","ENSG00000140525","Gastric cancer network 2; DNA repair pathways, full network","TP53 Regulates Transcription of DNA Repair Genes; Fanconi Anemia Pathway","Fanconi anemia pathway",3565.8,3503.3,3523.8,3704.2,3794.7,3855.3,0.9329499216149091,-0.1001284519419811,0.005960484694268305,2.2247184228961414,0.06463814512895406,1.1895111146687742,720]
["High","Q9NVM4","Protein arginine N-methyltransferase 7 [OS=Homo sapiens]",15,7,9,7,692,78.4,5.57,20.75,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","PRMT7","ENSG00000132600","Nitric oxide metabolism in cystic fibrosis","RMTs methylate histone arginines","",212.2,244,232.1,224.8,213.2,218.3,1.0487581898522016,0.0686820768515326,0.3404075379146173,0.4680008315531451,0.5765514221339115,0.23916195228415782,4610]
["High","Q9NVN3-1","Isoform 1 of Synembryn-B [OS=Homo sapiens]",12,4,7,4,536,60.8,5.88,11.38,"","","","RIC8B","","","","",212,218.6,213.2,201.6,168.2,171.9,1.1884807088794538,0.2491184860066257,0.03412476179621518,1.466930371480869,0.15554357274071695,0.808147929787744,1713]
["High","Q9NVS2","39S ribosomal protein S18a, mitochondrial [OS=Homo sapiens]",17,3,3,3,196,22.2,10.33,4.29,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS18A","ENSG00000096080","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",214.1,197.1,188.2,243.4,199.6,189.6,0.9475181789440403,-0.07777447200381933,0.5756623175500022,0.23983219822545804,0.7588673603630621,0.11983412620776616,5923]
["High","Q9NVX7-1","Kelch repeat and BTB domain-containing protein 4 [OS=Homo sapiens]",3,1,1,1,518,58.1,5.67,3.94,"","","","KBTBD4","ENSG00000123444; ENSG00000284900","","","",24.9,23.9,25.8,24.8,21.8,18.2,1.1512345679012346,0.20318181737061308,0.1752139326653835,0.7564313625565746,0.39402948912768265,0.4044712744023935,3472]
["High","Q9NVZ3","Adaptin ear-binding coat-associated protein 2 [OS=Homo sapiens]",28,6,14,6,263,28.3,8.38,33.44,"transport","plasma membrane;other membranes","","NECAP2","ENSG00000157191","","Cargo recognition for clathrin-mediated endocytosis","",719.1,736.8,752.2,630.4,689.2,610,1.1443304311774463,0.1945036977352,0.02221995188397516,1.6532568858337968,0.12517560195532326,0.9024803114509493,1386]
["High","Q9NW82","WD repeat-containing protein 70 [OS=Homo sapiens]",19,11,15,11,654,73.2,6.33,24.47,"other biological processes","nucleus;other cell component","other molecular function","WDR70","ENSG00000082068","","","",688.2,684.4,645,653.7,622.2,608.8,1.0705152013583064,0.09830528219566217,0.08204628648172542,1.0859410708813613,0.2562469619397248,0.5913412748947635,2500]
["High","Q9NWM8","Peptidyl-prolyl cis-trans isomerase FKBP14 [OS=Homo sapiens]",7,1,2,1,211,24.2,6.07,2.62,"protein metabolism;other metabolic processes","ER/Golgi","other molecular function","FKBP14","ENSG00000106080","","XBP1(S) activates chaperone genes","",32,33.2,34.4,33.6,32.9,28.1,1.0528541226215644,0.07430555872868566,0.4213759008057487,0.37533030604724515,0.6437298050266652,0.1912963823438467,5111]
["High","Q9NWQ9","Uncharacterized protein C14orf119 [OS=Homo sapiens]",14,2,2,2,140,16,4.94,1.73,"","cytosol;mitochondrion","","C14orf119","ENSG00000179933","","","",113,111.2,97.6,91.1,90.4,85.2,1.206599175103112,0.27094650117252,0.024263320522000597,1.6150497646524549,0.1312875998861959,0.8817762910873137,1443]
["High","Q9NWX5","Ankyrin repeat and SOCS box protein 6 [OS=Homo sapiens]",7,2,2,2,421,47.1,6.01,7.64,"protein metabolism;other metabolic processes;signal transduction","cytosol","","ASB6","ENSG00000148331","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",106.3,108,100.4,87.3,91.2,80.4,1.2155272305909621,0.2815822133983131,0.00890956613680248,2.0501434439968285,0.07878357009756938,1.1035643429157618,883]
["High","Q9NWZ5-1","Uridine-cytidine kinase-like 1 [OS=Homo sapiens]",11,6,9,6,548,61.1,7.36,8.55,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","UCKL1","ENSG00000198276; ENSPPAG00000038781","Pyrimidine metabolism","Pyrimidine salvage","Pyrimidine metabolism; Drug metabolism; Metabolic pathways",313.8,315.7,294.7,292.2,312.6,299.1,1.0224582365305896,0.032041915850914995,0.4936045232074413,0.30662086924419946,0.7022711583825987,0.15349516728425935,5488]
["High","Q9NX24","H/ACA ribonucleoprotein complex subunit 2 [OS=Homo sapiens]",18,2,4,2,153,17.2,8.22,11.53,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","NHP2","ENSG00000145912","","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","Ribosome biogenesis in eukaryotes",90,73.2,71.6,100.2,77.5,79.5,0.9129082426127527,-0.13145823421789515,0.4689411904274137,0.3288816184241682,0.6834968853569622,0.16526346013839216,5357]
["High","Q9NX61","Transmembrane protein 161A [OS=Homo sapiens]",3,1,2,1,479,53.6,8.44,7.7,"stress response;other biological processes","other membranes","","TMEM161A","ENSG00000064545","","","",46.3,40.7,47,41.4,53.7,56.6,0.883322346736981,-0.17898808490189858,0.30903926952170124,0.5099863314069496,0.5455524794088725,0.263163466117918,4423]
["Medium","Q9NX76","CKLF-like MARVEL transmembrane domain-containing protein 6 [OS=Homo sapiens]",5,1,4,1,183,20.4,5.29,5.8,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","","CMTM6","ENSG00000091317","","Neutrophil degranulation","",68.2,60.3,51.9,47.5,50.5,49.8,1.2205683355886332,0.2875530691092299,0.08597512804284695,1.065627168710247,0.26335574725717886,0.5794571995208792,2549]
["High","Q9NXF1","Testis-expressed protein 10 [OS=Homo sapiens]",15,13,34,13,929,105.6,9.36,68.49,"","mitochondrion;nucleus","","TEX10","ENSG00000136891","","Major pathway of rRNA processing in the nucleolus and cytosol","",1160.6,1087.9,1085.4,1151.1,1066.3,1164.5,0.9858067949968953,-0.020623169594857067,0.7055498514006913,0.15147229527127984,0.842989019087467,0.07417808252920755,6535]
["High","Q9NXN4-1","Ganglioside-induced differentiation-associated protein 2 [OS=Homo sapiens]",9,3,3,3,497,56.2,5.74,4.92,"other biological processes","","","GDAP2","ENSG00000196505","","","",32,39,30.3,31.1,29,30.5,1.1181015452538632,0.16105121875490314,0.2621197494657923,0.5815002558146168,0.4978426182994177,0.3029079279363312,4111]
["High","Q9NXS2","Glutaminyl-peptide cyclotransferase-like protein [OS=Homo sapiens]",2,2,3,2,382,42.9,9.82,6.22,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","QPCTL","ENSG00000011478","","","",235.8,224.1,213.5,178.5,169.9,204.1,1.2188235294117649,0.28548925666149,0.029263500101093767,1.5336737307164428,0.14479683700211668,0.8392409249312089,1578]
["High","Q9NY27","Serine/threonine-protein phosphatase 4 regulatory subunit 2 [OS=Homo sapiens]",60,17,47,17,417,46.9,4.54,107.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP4R2","ENSG00000163605","16p11.2 proximal deletion syndrome","Processing of DNA double-strand break ends","",1689.8,1624.9,1631.2,1770.6,1549,1720.9,0.9812320206328736,-0.027333780626493286,0.6767354369816425,0.1695810812634975,0.824843941922052,0.08362821093266502,6406]
["High","Q9NYF3","protein FAM53C [OS=Homo sapiens]",3,1,2,1,392,43.1,8.65,4.74,"transport","nucleus","","FAM53C","ENSG00000120709","","","",31.8,30.1,35.9,30.8,23.1,21.3,1.3005319148936172,0.3791018032745966,0.08999037101362839,1.0458039576647535,0.2702480064901579,0.568237500976936,2600]
["Medium","Q9NYG2-1","Palmitoyltransferase ZDHHC3 [OS=Homo sapiens]",3,1,2,1,299,34.1,8.18,0,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","ZDHHC3","ENSCCAG00000029642; ENSG00000163812","","","",45.7,44.1,47.3,38.3,35.5,46.2,1.1425000000000003,0.1921941652833454,0.1625220648468555,0.789087668588435,0.37789525977493976,0.42262855573182967,3358]
["High","Q9NYP3-1","Protein downstream neighbor of son [OS=Homo sapiens]",11,4,5,4,566,62.7,8.66,3.66,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction","nucleus;other cell component","","DONSON","ENSG00000159147","","","",142.8,144.2,132.1,171.4,175.1,189.3,0.7821948488241882,-0.3544000597117596,0.004285595609422249,2.367988811568151,0.05642821335306732,1.248503700273778,593]
["High","Q9NYU1","UDP-glucose:glycoprotein glucosyltransferase 2 [OS=Homo sapiens]",5,7,9,6,1516,174.6,6.89,9.87,"protein metabolism;other metabolic processes;stress response","ER/Golgi;other cell component","other molecular function","UGGT2","ENSG00000102595","","ER Quality Control Compartment (ERQC)","Protein processing in endoplasmic reticulum",166.1,151.6,162.7,143.7,138.2,155.5,1.098308184727938,0.13528293065754093,0.10001732169325853,0.9999247793565625,0.2839764537385318,0.5467176685281898,2750]
["High","Q9NYZ3","G2 and S phase-expressed protein 1 [OS=Homo sapiens]",9,5,8,5,720,76.6,9.39,10.13,"cell cycle OR cell proliferation;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus","cytoskeletal activity","GTSE1","ENSG00000075218","","The role of GTSE1 in G2/M progression after G2 checkpoint; G2/M Checkpoints","p53 signaling pathway",196.8,206.2,164.1,161,120,127.3,1.3889297085476366,0.47397358873919543,0.042018147231128004,1.3765631015025876,0.17553648666701308,0.7556325982227843,1869]
["High","Q9NZ53-1","Podocalyxin-like protein 2 [OS=Homo sapiens]",2,1,2,1,605,65,4.34,2.38,"cell adhesion","plasma membrane;other membranes;ER/Golgi","other molecular function","PODXL2","ENSG00000114631","","Cytosolic sulfonation of small molecules","",21.7,18.1,24.5,19.8,21.4,21.1,1.0321027287319422,0.045586574303945436,0.7454575516751873,0.1275770813834791,0.865764177224433,0.06260038797956734,6723]
["High","Q9NZ72","Stathmin-3 [OS=Homo sapiens]",13,3,3,2,180,21,7.49,5.11,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","STMN3","ENSG00000197457","","","",110.2,96.7,101.2,99.4,113.9,93.2,1.0052202283849918,0.007511608461207364,0.9453078409854552,0.024426739776291395,0.9742560219660024,0.011326901112873005,7576]
["High","Q9NZI7","Upstream-binding protein 1 [OS=Homo sapiens]",16,6,15,5,540,60.5,6.35,38.79,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBP1","ENSG00000153560","","","",461.2,506.9,466.6,396.2,476.4,406.4,1.1217357310398748,0.16573283243062487,0.14841555840853649,0.8285205695637468,0.36168186019158954,0.4416732723173114,3204]
["High","Q9NZJ5","Eukaryotic translation initiation factor 2-alpha kinase 3 [OS=Homo sapiens]",14,10,17,10,1116,125.1,5.43,43.91,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","EIF2AK3","ENSG00000172071","Translation factors; Alzheimer's disease and miRNA effects; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; 7q11.23 copy number variation syndrome; Alzheimer's disease","Signaling by ALK fusions and activated point mutants; ALK mutants bind TKIs; PERK regulates gene expression","Mitophagy; Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Hepatitis C; Measles; Herpes simplex virus 1 infection; Lipid and atherosclerosis",629.4,624.6,651.7,552,588.1,584.2,1.105202111001566,0.14431022289874806,0.012953091556280213,1.887626564741538,0.09330049711387076,1.0301160422852706,1084]
["High","Q9NZM5","ribosome biogenesis protein NOP53 [OS=Homo sapiens]",15,5,9,5,478,54.4,10.32,18.47,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP53","ENSG00000105373","","","",368.2,320.2,305.6,482.2,288,403.3,0.8470387729015764,-0.23950008496088432,0.37131501022040986,0.43025749428546606,0.6048878781141164,0.21832511861861859,4793]
["High","Q9NZV5-1","Selenoprotein N [OS=Homo sapiens]",5,3,7,3,590,65.8,5.48,12.9,"cell organization and biogenesis;stress response;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SELENON","ENSG00000162430","Selenium micronutrient network","","",476.5,454.8,451.7,455.3,475,464.1,0.9918244406196213,-0.01184331808782864,0.7141251706723224,0.14622565913718633,0.8481730046561443,0.07151555422415652,6574]
["High","Q9P000-1","COMM domain-containing protein 9 [OS=Homo sapiens]",34,4,5,4,198,21.8,5.88,11.85,"transport;other biological processes","non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component","","COMMD9","ENSG00000110442","","Neddylation; Neutrophil degranulation","",303.6,300.1,295.6,318.6,346.4,345.2,0.8902197584636706,-0.16776657306683732,0.016850218432331907,1.7733944649207407,0.10801847743813427,0.9665019485589619,1218]
["High","Q9P0J0","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [OS=Homo sapiens]",43,5,31,5,144,16.7,8.43,47.91,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;mitochondrion;nucleus;other cell component","transporter activity;other molecular function","NDUFA13","ENSG00000186010","Nucleotide-binding oligomerization domain (NOD) pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease","Complex I biogenesis","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy",896.8,845.2,858.4,770.7,876.5,817.1,1.0552286653410705,0.0775556611195448,0.2565951172301263,0.5907516121083568,0.4912934466240378,0.3086590288918426,4078]
["High","Q9P0N9","TBC1 domain family member 7 [OS=Homo sapiens]",29,6,8,6,293,34,7.94,12.97,"other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","TBC1D7","ENSG00000145979","Fragile X syndrome","TBC/RABGAPs","mTOR signaling pathway",214.6,211.3,226.8,212.3,220.6,209.6,1.015875486381323,0.022723584995430594,0.5867281236562476,0.2315630942346845,0.7653145989822888,0.11616000208022173,5986]
["High","Q9P0S3","ORM1-like protein 1 [OS=Homo sapiens]",20,2,5,2,153,17.4,9.64,11.03,"other metabolic processes;other biological processes","other membranes;ER/Golgi","","ORMDL1","ENSG00000128699","","Sphingolipid de novo biosynthesis","",196.6,202,205.9,156.3,167.4,160.5,1.248451053283767,0.3201392601375493,6.7950996870921063E-4,3.167804167594261,0.024563027017044062,1.6097181140865564,216]
["High","Q9P1F3","Costars family protein ABRACL [OS=Homo sapiens]",16,1,3,1,81,9.1,6.29,3.27,"other biological processes","","","ABRACL","ENSG00000146386","","","",28.9,27.4,29.5,33.6,23.4,25.3,1.0425273390036451,0.06008521707791984,0.7333583663638856,0.1346837490954375,0.8598982016172427,0.06555295932934667,6659]
["High","Q9P1U1-1","Actin-related protein 3B [OS=Homo sapiens]",25,8,34,4,418,47.6,5.88,59.14,"","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTR3B","ENSCANG00000039781; ENSCATG00000043872; ENSCCAG00000019061; ENSCJAG00000019650; ENSCSAG00000006554; ENSG00000133627; ENSMFAG00000034566; ENSMMUG00000018920; ENSMNEG00000033219; ENSPANG00000006816; ENSPPYG00000018206; ENSPTRG00000019897; ENSRROG00000045018","","","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection",361.5,365.5,386.6,366.9,355.7,356.8,1.0316842690383548,0.04500152387609006,0.2538989570230544,0.5953390831359768,0.4882864671024652,0.31132531205453545,4060]
["High","Q9P219","Protein Daple [OS=Homo sapiens]",7,12,13,12,2028,228.1,6.23,29.23,"cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","CCDC88C","ENSG00000015133","Ectoderm differentiation; Ectoderm differentiation","Negative regulation of TCF-dependent signaling by DVL-interacting proteins","",681.5,726.9,686.5,760.2,734.4,758.8,0.9296618443241327,-0.10522204988419252,0.03366538791636912,1.472816376919549,0.15498782361498234,0.8097024201816087,1696]
["High","Q9P275","Ubiquitin carboxyl-terminal hydrolase 36 [OS=Homo sapiens]",15,14,22,14,1121,122.6,9.67,34.03,"","","","","","","","",959.4,964.7,1032.7,1006.6,962.2,923.9,1.0221592284025305,0.03161995178770008,0.5592242942967083,0.2524139698628423,0.7469078497893771,0.12673297622562452,5846]
["High","Q9P2D3-1","HEAT repeat-containing protein 5B [OS=Homo sapiens]",7,9,13,9,2071,224.2,7.17,17.02,"transport;other biological processes","cytosol;other cell component","","HEATR5B","ENSG00000008869","","","",313.6,322,326.1,314,337.3,323.9,0.9861566858080394,-0.020111207027293222,0.589788028487251,0.22930404700072268,0.7675108210714093,0.1149154927257309,6000]
["High","Q9P2E5-1","Chondroitin sulfate glucuronyltransferase [OS=Homo sapiens]",8,6,8,6,772,85.9,7.83,9.18,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHPF2","ENSG00000033100; ENSGGOG00000001088","","Chondroitin sulfate biosynthesis","Glycosaminoglycan biosynthesis; Metabolic pathways",521,536.6,527.7,513.3,499.6,500.1,1.0477858559153999,0.06734389227857392,0.01934731216568706,1.713379361016712,0.11602443424706955,0.9354505405902499,1302]
["High","Q9P2J5","Leucine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",48,52,268,52,1176,134.4,7.3,493.34,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","LARS1","ENSG00000133706","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",9502.7,9322.7,9375.7,9479,10019.8,9960.1,0.9573032258502524,-0.06295212405277252,0.07954809991430181,1.0993701894503238,0.25197223696992643,0.5986473084049371,2465]
["High","Q9P2L0-1","WD repeat-containing protein 35 [OS=Homo sapiens]",7,5,9,5,1181,133.5,6.38,22.32,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytoskeleton;other cell component","","WDR35","ENSG00000118965","Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",212.6,208.3,209.2,219,213.9,243.4,0.9316871211001034,-0.10208254410805492,0.16934737046690923,0.7712215424535249,0.3865139633456963,0.4128348119799521,3421]
["High","Q9P2R3","Rabankyrin-5 [OS=Homo sapiens]",16,15,25,14,1169,128.3,6.1,57.1,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ANKFY1","ENSG00000185722","","RHOD GTPase cycle","",944.8,986.6,982.5,849.8,905.7,827.2,1.128237890579626,0.1740712941325182,0.014723805797796438,1.8319799193903799,0.10005524427258014,0.9997601434200297,1149]
["Medium","Q9P2Z0","THAP domain-containing protein 10 [OS=Homo sapiens]",4,1,2,1,257,28.3,8.6,5.18,"","","nucleic acid binding activity;other molecular function","THAP10","ENSG00000129028","","","",125.2,146.7,148.5,128.1,125.5,111.5,1.1514653519583675,0.2034710005272938,0.11243225712946409,0.9491090705862458,0.3020891478550776,0.5198648758896132,2906]
["High","Q9UBB6","Neurochondrin [OS=Homo sapiens]",37,21,61,21,729,78.8,5.48,142.15,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","NCDN","ENSG00000020129","Splicing factor NOVA regulated synaptic proteins","","",1803.4,1763.5,1756.3,1543,1578.3,1610.8,1.1249128293992094,0.16981320991697726,1.2878527469472494E-3,2.8901337913583514,0.03329653724557657,1.4776009296568666,302]
["High","Q9UBF8-2","Isoform 2 of Phosphatidylinositol 4-kinase beta [OS=Homo sapiens]",5,3,3,3,801,89.8,6.44,4.63,"","","","PI4KB","","","","",80.3,74.8,74,70.1,59.8,81.5,1.0837275307473984,0.11600208192199213,0.42009332917925185,0.3766542147334735,0.6427765459987455,0.19193997840706958,5103]
["High","Q9UBM7","7-dehydrocholesterol reductase [OS=Homo sapiens]",21,10,65,10,475,54.5,8.7,99.19,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","DHCR7","ENSG00000172893","Vitamin D metabolism; Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol","Steroid biosynthesis; Metabolic pathways",2314,2218.4,2286.7,2208.4,2286.8,2263.9,{"$f":"AVERAGE(T7106:V7106)/AVERAGE(W7106:Y7106)","v":1.0088769214836295},{"$f":"LOG(Z7106,2)","v":0.012750182773482542},{"$f":"TTEST(T7106:V7106,W7106:Y7106,2,2)","v":0.6151416570601196},{"$f":"-LOG10(AB7106)","v":0.21102486179309918},{"$f":"AB7106*7808/AF7106","v":0.785321461465895},{"$f":"-LOG10(AD7106)","v":0.10495253387474629},6116]
["High","Q9UBP6","tRNA (guanine-N(7)-)-methyltransferase [OS=Homo sapiens]",26,6,13,6,276,31.5,7.64,38.11,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","METTL1","ENSG00000037897","","tRNA modification in the nucleus and cytosol","",628,603.7,611,681.9,677.4,688.5,0.8998437347397207,-0.15225360754500575,9.748172643713126E-4,3.01107678790463,0.029731926563325035,1.5267769485578442,256]
["High","Q9UBQ6","Exostosin-like 2 [OS=Homo sapiens]",14,3,5,3,330,37.4,8.95,5.45,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EXTL2","ENSG00000162694","","XBP1(S) activates chaperone genes","Glycosaminoglycan biosynthesis; Metabolic pathways",271.4,291.4,271.3,230.4,290.9,256.2,1.072797427652733,0.10137768307361628,0.37143710784563677,0.4301147109151399,0.6047082856669583,0.21845408068331554,4796]
["High","Q9UBU8-2","Isoform 2 of Mortality factor 4-like protein 1 [OS=Homo sapiens]",38,11,34,9,323,37.2,9.19,90.42,"","","","MORF4L1","","","","",1102.9,1038.5,1025.2,1198.4,1120.3,1180.8,0.9048721245892272,-0.14421416816773078,0.030111147452278546,1.5212726944142527,0.14721843413111516,0.8320378058941001,1597]
["High","Q9UBV8","Peflin [OS=Homo sapiens]",7,2,12,2,284,30.4,6.54,19.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PEF1","ENSG00000162517","","","",398.1,419.1,399,445.8,433.2,405.9,0.9465328041092692,-0.07927558842414338,0.16812736230435615,0.774361600476334,0.38474163097081265,0.41483081831318397,3412]
["High","Q9UDT6-2","Isoform 2 of CAP-Gly domain-containing linker protein 2 [OS=Homo sapiens]",26,25,49,1,1011,111.7,6.83,119.09,"","","","CLIP2","","","","",103.7,98.8,114.4,106.3,118,118.6,0.9241761446485856,-0.11376024455340081,0.22860096755329193,0.6409219357860285,0.4600299883134287,0.33721385672160037,3880]
["High","Q9UDY2","Tight junction protein ZO-2 [OS=Homo sapiens]",33,31,97,1,1190,133.9,7.4,182.97,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","TJP2","ENSG00000119139","1q21.1 copy number variation syndrome","Signaling by Hippo; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Apoptotic cleavage of cell adhesion  proteins","Tight junction; Vibrio cholerae infection",4041,4141.6,4128,4749.9,4445.8,4686,0.886822219180648,-0.17328317774917262,0.005864457896116074,2.2317721273859012,0.06458347990532341,1.1898785579103324,709]
["High","Q9UEG4","zinc finger protein 629 [OS=Homo sapiens]",13,7,11,5,869,96.6,7.93,17.83,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF629","ENSG00000102870","","","",226.3,198.5,203.7,219.9,205.6,224.5,0.966923076923077,-0.04852697349530897,0.523203700746923,0.2813291928025134,0.7227838810035341,0.14099154132039904,5652]
["High","Q9UG63","ATP-binding cassette sub-family F member 2 [OS=Homo sapiens]",23,15,41,15,623,71.2,7.37,64.83,"transport","","transporter activity;other molecular function","ABCF2","ENSG00000033050","VEGFA-VEGFR2 signaling pathway","","Pathogenic Escherichia coli infection",2296.5,2387.1,2353.8,2501.3,2367.3,2433.1,0.9638029499979457,-0.05318987801687501,0.13331445944945555,0.8751227439203656,0.33807057466104223,0.47099262816492826,3079]
["High","Q9UGN5-1","Poly [ADP-ribose] polymerase 2 [OS=Homo sapiens]",3,2,4,2,583,66.2,8.88,5.13,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP2","ENSG00000129484","NAD+ biosynthetic pathways; Base excision repair; Peroxiredoxin 2 induced ovarian failure; DNA repair pathways, full network","Dual Incision in GG-NER; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; HDR through MMEJ (alt-NHEJ); POLB-Dependent Long Patch Base Excision Repair","Base excision repair; Apoptosis",187.8,196.9,183.4,224.5,232.9,226.5,0.8306769995613394,-0.2676404863842987,1.2113197819135233E-3,2.91674119031102,0.03261374088683031,1.4865993835513405,290]
["High","Q9UGU0","Transcription factor 20 [OS=Homo sapiens]",7,12,14,12,1960,211.6,9.04,29.68,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","TCF20","ENSG00000100207; ENSG00000262024; ENSG00000276461; ENSG00000280467; ENSG00000281897; ENSG00000282892; ENSG00000283026; ENSG00000283681","Matrix metalloproteinases","","",800.1,839.8,837.4,933.9,802.7,833.8,{"$f":"AVERAGE(T7170:V7170)/AVERAGE(W7170:Y7170)","v":0.9637799564270155},{"$f":"LOG(Z7170,2)","v":-0.05322429698857712},{"$f":"TTEST(T7170:V7170,W7170:Y7170,2,2)","v":0.4972792523180877},{"$f":"-LOG10(AB7170)","v":0.3033996601961607},{"$f":"AB7170*7808/AF7170","v":0.7049303562272383},{"$f":"-LOG10(AD7170)","v":0.15185378712241135},5508]
["High","Q9UGY1","Nucleolar protein 12 [OS=Homo sapiens]",21,3,5,2,213,24.6,10.23,11.14,"","nucleus","nucleic acid binding activity;other molecular function","NOL12","ENSG00000273899","","Major pathway of rRNA processing in the nucleolus and cytosol","",70.2,86.2,65,88.3,66.4,73.3,0.9710526315789473,-0.04237860227055192,0.8205098963265478,0.08591617647061778,0.9091161161512253,0.041380643309250675,7047]
["High","Q9UHB7-1","AF4/FMR2 family member 4 [OS=Homo sapiens]",12,10,14,10,1163,127.4,9.31,27.56,"other biological processes","nucleus;other cell component","","AFF4","ENSG00000072364","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",317.8,349.4,365.3,391.7,341,365.7,0.9400036416605971,-0.08926174895293072,0.33853922930274444,0.47039099881765356,0.5758854689315531,0.23966387969627936,4590]
["High","Q9UHD2","Serine/threonine-protein kinase TBK1 [OS=Homo sapiens]",24,14,25,14,729,83.6,6.79,68.53,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;kinase activity;other molecular function","TBK1","ENSG00000183735","TNF-alpha signaling pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Toll-like receptor signaling pathway","Negative regulators of DDX58/IFIH1 signaling; Potential therapeutics for SARS; Interleukin-37 signaling; IRF3-mediated induction of type I IFN; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; TICAM1-dependent activation of IRF3/IRF7; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Regulation of innate immune responses to cytosolic DNA; STAT6-mediated induction of chemokines; IRF3 mediated activation of type 1 IFN","Ras signaling pathway; Mitophagy; Autophagy; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; IL-17 signaling pathway; Alcoholic liver disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Shigellosis; Yersinia infection; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis",1201.7,1153.2,1137.8,1145.1,1165.1,1113.1,1.0202728361522508,0.02895500193137417,0.39844543193166937,0.39963114787811016,0.6267248051012236,0.20292311604616703,4964]
["High","Q9UHI8","a disintegrin and metalloproteinase with thrombospondin motifs 1 [OS=Homo sapiens]",9,6,8,6,967,105.3,6.83,17.04,"cell organization and biogenesis;protein metabolism;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","other molecular function","ADAMTS1","ENSG00000154734","VEGFA-VEGFR2 signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Malignant pleural mesothelioma","Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins; Degradation of the extracellular matrix","",253.7,252.5,277.2,208.8,225.6,223.5,1.1907584739322086,0.2518808155559968,0.012179635865664918,1.9143656956026798,0.09039790574060046,1.0438416307617646,1052]
["High","Q9UHL0-1","ATP-dependent RNA helicase DDX25 [OS=Homo sapiens]",8,2,10,1,483,54.7,6.28,20.64,"other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX25","ENSG00000109832","","","",18.9,14.8,16.7,21.5,27.2,24,0.6932599724896836,-0.5285316304196779,0.02157713547794737,1.66600621158523,0.12261591980481301,0.9114531396501262,1374]
["High","Q9UHQ4","B-cell receptor-associated protein 29 [OS=Homo sapiens]",27,8,13,8,241,28.3,9.54,25.33,"transport;other biological processes","other membranes;ER/Golgi","","BCAP29","ENSG00000075790; ENSG00000283852","","","",995.7,988.4,981.9,875.3,877.5,891.1,1.1218276031619954,0.16585098684421584,7.165599152446143E-5,4.144747490162354,0.010970391800450879,1.9597778616016546,51]
["High","Q9UHV7","mediator of RNA polymerase II transcription subunit 13 [OS=Homo sapiens]",0,1,1,1,2174,239.1,5.64,2.62,"other biological processes","nucleus","other molecular function","MED13","ENSG00000108510","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Thyroid hormone signaling pathway",56,58.3,52.8,70,59.8,53.1,0.9136139967195188,-0.13034334168752862,0.36559124647569113,0.4370042113321231,0.6003231235504093,0.22161492794692048,4755]
["High","Q9UI10-1","translation initiation factor eIF-2B subunit delta [OS=Homo sapiens]",34,13,32,1,523,57.5,9.38,82.69,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF2B4","ENSG00000115211","Translation factors","Recycling of eIF2:GDP","Herpes simplex virus 1 infection",15.2,22.3,19.5,16,15.7,18.6,1.1332007952286283,0.180403519246577,0.37914417914154075,0.42119560718662125,0.6113915222505473,0.2136805876336999,4842]
["High","Q9UI95","Mitotic spindle assembly checkpoint protein MAD2B [OS=Homo sapiens]",16,3,5,3,211,24.3,6.52,2.43,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD2L2","ENSG00000116670","Cell cycle","Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Bacterial invasion of epithelial cells",127.2,134.7,133,143.7,195.3,154.1,0.8008517542080713,-0.32039288504077057,0.10890120337679834,0.9629673211899032,0.2973079006874271,0.5267935496603109,2860]
["High","Q9UIF8-1","Bromodomain adjacent to zinc finger domain protein 2B [OS=Homo sapiens]",1,2,2,2,2168,240.3,6.54,6.12,"cell organization and biogenesis;other biological processes","nucleus","nucleic acid binding activity;other molecular function","BAZ2B","ENSG00000123636","","","",77.6,81.2,71.7,80.9,84.4,87.4,0.9121487930352196,-0.1326589136280749,0.09146184992343263,1.03876001875007,0.2722585300046367,0.5650185046817882,2623]
["High","Q9UIJ7-1","GTP:AMP phosphotransferase AK3, mitochondrial [OS=Homo sapiens]",65,13,42,13,227,25.6,9.16,65.5,"other metabolic processes;stress response","mitochondrion;other cell component","kinase activity;other molecular function","AK3","ENSG00000147853; ENSGGOG00000028122","","Factors involved in megakaryocyte development and platelet production","Purine metabolism; Biosynthesis of cofactors",2154.9,2111.8,2087,1848.2,1934.9,1893.2,1.1193383013582792,0.1626461327661574,2.1125899684488855E-3,2.6751847867716942,0.041032593218032085,1.3868710351975286,402]
["High","Q9UIW2","Plexin-A1 [OS=Homo sapiens]",10,16,21,13,1896,210.9,6.92,39.52,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","PLXNA1","ENSG00000114554","","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Sema3A PAK dependent Axon repulsion; RHOD GTPase cycle; RND1 GTPase cycle; CRMPs in Sema3A signaling; Other semaphorin interactions","Axon guidance",689.3,699.4,670,709.3,633.2,713.2,1.001459356910055,2.1038721999233696E-3,0.972667250969373,0.012035706271861322,0.9866942829113764,5.817388172705636E-3,7697]
["Medium","Q9UJ99","Cadherin-22 [OS=Homo sapiens]",2,1,4,1,828,89,4.81,0,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CDH22","ENSG00000149654","Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Malignant pleural mesothelioma","","",30.5,24.8,24.2,34.4,34.2,25.6,0.8439490445859874,-0.24477219944106524,0.23714183163040806,0.6249918300630725,0.46935447943478487,0.3284990329498761,3945]
["High","Q9UJQ4","Sal-like protein 4 [OS=Homo sapiens]",19,14,33,13,1053,112.2,7.47,77.44,"cell cycle OR cell proliferation;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SALL4","ENSG00000101115","Vitamin D receptor pathway; Wnt/beta-catenin signaling pathway in leukemia","Regulation of PTEN gene transcription; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","",1885.9,1880.4,1917.3,2486.9,2293.8,2439.5,0.7871804105149441,-0.3452337761469414,9.8336040207978566E-4,3.007287283847857,0.029875789958906482,1.5246806025205162,257]
["High","Q9UJU6-2","Isoform 2 of Drebrin-like protein [OS=Homo sapiens]",47,15,51,1,431,48.3,5.05,132.53,"","","","DBNL","","","","",100.4,105.4,94.8,96.5,94.1,123.9,0.9558028616852147,-0.0652150078502869,0.6683327528489396,0.1750072549723569,0.8192059865376012,0.08660688264907193,6370]
["High","Q9UJX4","Anaphase-promoting complex subunit 5 [OS=Homo sapiens]",21,11,18,11,755,85,6.87,38.35,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ANAPC5","ENSG00000089053","Cell cycle","Separation of Sister Chromatids; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of APC/C activators between G1/S and early anaphase; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; IL-17 signaling pathway; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection",368.9,360,366.5,335.2,353.3,360.2,1.0445313244969965,0.06285575810041659,0.12059525319000192,0.9186697863414762,0.3169329306319539,0.49903263348650484,2971]
["High","Q9UJZ1","Stomatin-like protein 2, mitochondrial [OS=Homo sapiens]",67,18,146,18,356,38.5,7.39,292.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","signal transduction activity or receptor binding;other molecular function","STOML2","ENSG00000165283","","Processing of SMDT1","",3204.9,3187.6,3196.7,3096.2,3146.5,3094,1.027043816337678,0.038497732059838315,0.00921894534944639,2.0353187595444298,0.07962558107132457,1.0989473853611575,904]
["High","Q9UK58","Cyclin-L1 [OS=Homo sapiens]",9,3,4,3,526,59.6,10.7,9.86,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","enzyme regulator activity","CCNL1","ENSG00000163660","","","",165.5,161.2,172.8,203.9,185.9,182.8,0.8723367097450226,-0.19704299231957237,0.030111852500966933,1.5212625255832382,0.14712975239521264,0.8322994959025753,1598]
["High","Q9UKA9-1","Polypyrimidine tract-binding protein 2 [OS=Homo sapiens]",27,8,38,1,531,57.5,8.66,69.19,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","LOC101350812; PTBP2","ENSANAG00000033752; ENSCSAG00000001494; ENSG00000117569; ENSMMUG00000016130; ENSPANG00000001229; ENSPPYG00000001132","Genes targeted by miRNAs in adipocytes; mRNA processing","","",446.7,453.8,408.3,570.5,622.8,588.8,0.7344144548566298,-0.4453336405137052,1.6337568983724304E-3,2.7868125656432245,0.03655121450570755,1.437098187943769,349]
["High","Q9UKF6","Cleavage and polyadenylation specificity factor subunit 3 [OS=Homo sapiens]",21,11,23,11,684,77.4,5.6,59.14,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","CPSF3","ENSG00000119203","mRNA processing","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript","mRNA surveillance pathway",548,519.5,519.5,503.5,569.5,556.7,0.9737988586856476,-0.0383042851506454,0.5585005892804313,0.2529763643189995,0.7465797981683971,0.12692376590005824,5841]
["High","Q9UKK3","Poly [ADP-ribose] polymerase 4 [OS=Homo sapiens]",3,3,3,3,1724,192.5,5.66,3.75,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP4","ENSG00000102699","NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome","Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein","Base excision repair; Apoptosis",43.7,52.1,43,44.9,54.9,42.5,0.9754040758959944,-0.03592809394822141,0.8196330631029393,0.08638053095222188,0.9090475790778054,0.04141338543569866,7040]
["High","Q9UKM9-2","Isoform 1 of RNA-binding protein Raly [OS=Homo sapiens]",55,14,62,14,290,30.3,9.63,140.27,"","","","RALY","","","","",2958.1,3060.2,2922.9,2984.4,3262.8,3063.6,0.9603041629075909,-0.058436663202612635,0.25367055682015094,0.5957299377944083,0.48808765590235054,0.3115021758331001,4058]
["High","Q9UKU7","Isobutyryl-CoA dehydrogenase, mitochondrial [OS=Homo sapiens]",9,4,5,4,415,45,7.85,8.28,"other metabolic processes","mitochondrion","other molecular function","ACAD8","ENSG00000151498","","Branched-chain amino acid catabolism","Valine, leucine and isoleucine degradation; Metabolic pathways",322.3,286.1,299.7,270.5,325.3,310.2,1.0023178807947022,0.003340125615072456,0.973022624451958,0.01187706151951179,0.9867983701416921,0.005771576489814694,7699]
["High","Q9UKW4","Guanine nucleotide exchange factor VAV3 [OS=Homo sapiens]",4,4,6,3,847,97.7,7.05,14.63,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;cytosol","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","VAV3","ENSG00000134215","Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mesodermal commitment pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; T-cell receptor (TCR) signaling pathway","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOG GTPase cycle; RAC2 GTPase cycle; FCERI mediated Ca+2 mobilization; FCERI mediated MAPK activation; DAP12 signaling; EPH-ephrin mediated repulsion of cells; GPVI-mediated activation cascade; VEGFR2 mediated vascular permeability","Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Yersinia infection; Proteoglycans in cancer; Lipid and atherosclerosis",146.3,133.8,151.1,173.4,154,155.4,0.8931234465617235,-0.16306849800251566,0.10094023878375971,0.9959356722361099,0.2849390399217628,0.5452480433507663,2766]
["High","Q9UL15-1","BAG family molecular chaperone regulator 5 [OS=Homo sapiens]",27,9,18,9,447,51.2,6.05,33.98,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","BAG5","ENSG00000166170","","Regulation of HSF1-mediated heat shock response","",526.9,491.5,525.5,468.1,467.7,497.3,1.0773149117298164,0.1074400281390375,0.07157123809876254,1.1452614699341672,0.2372943639384874,0.6247125767404468,2355]
["High","Q9UL63-1","muskelin [OS=Homo sapiens]",21,11,18,11,735,84.7,6.34,26.5,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","MKLN1","ENSG00000128585","Ciliary landscape","","",639,625.7,649.5,647.2,669.9,593.8,1.001726934952117,0.002489291687065258,0.9650344129257685,0.015457199529481705,0.9838084209589243,7.089464394759026E-3,7659]
["High","Q9ULD9","zinc finger protein 608 [OS=Homo sapiens]",2,3,6,2,1512,162.1,8.79,11.89,"other biological processes","nucleus","other molecular function","ZNF608","ENSG00000168916","","","",167.2,167.2,170,231.7,146.9,186.2,0.8930594900849859,-0.16317181294296043,0.45769462175013026,0.3394241908236597,0.6747884453597087,0.17083236259666776,5296]
["High","Q9ULH1-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",3,3,5,3,1129,125.4,7.31,9.77,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ASAP1","ENSG00000153317","EGF/EGFR signaling pathway; CCL18 signaling pathway","VxPx cargo-targeting to cilium","Endocytosis; Fc gamma R-mediated phagocytosis",70.3,85.1,78.4,60.1,55.7,54.6,1.3720657276995303,0.4563495943058179,0.010051006134076966,1.9977904619642324,0.0825218253363543,1.083431174243011,951]
["High","Q9ULJ7-1","Ankyrin repeat domain-containing protein 50 [OS=Homo sapiens]",5,5,7,5,1429,155.8,6.6,20.17,"transport","other cytoplasmic organelle","","ANKRD50","ENSG00000151458","","","",269.8,260.5,289.4,250,249.1,231.2,1.1224154457072435,0.1666067673241203,0.046822784469479725,1.3295427631346426,0.18681262194057113,0.7285937841340084,1957]
["High","Q9ULT8","E3 ubiquitin-protein ligase hectd1 [OS=Homo sapiens]",16,39,61,39,2610,289.2,5.35,119.59,"protein metabolism;other metabolic processes;developmental processes;other biological processes","","other molecular function","HECTD1","ENSG00000092148","","Antigen processing: Ubiquitination & Proteasome degradation","",2771.6,2736.8,2727.9,3027.1,3051.4,3065.9,0.9006933205021652,-0.1508921323632709,6.5409877485614183E-5,4.184356664312027,0.011607280077447173,1.935269536139579,44]
["High","Q9ULV0","unconventional myosin-Vb [OS=Homo sapiens]",3,6,6,2,1848,213.5,7.2,9.72,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5B","ENSG00000167306","","Vasopressin regulates renal water homeostasis via Aquaporins","Pathogenic Escherichia coli infection",84.6,102,83.7,82.1,83.1,77.7,1.1128036228900784,0.15419902189883,0.21364762458348466,0.6703019314731354,0.4423655934096654,0.35421865922012025,3771]
["High","Q9ULZ3","apoptosis-associated speck-like protein containing a CARD [OS=Homo sapiens]",50,10,31,10,195,21.6,6.34,70.96,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PYCARD","ENSG00000103490","Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling","Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; CLEC7A/inflammasome pathway","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Lipid and atherosclerosis",1394.1,1379.1,1402,1406.9,1586.6,1556.9,0.9175457102672293,-0.12414806299889641,0.08935438433042142,1.0488841332110026,0.2690624885661128,0.5701468453217187,2593]
["High","Q9UM47","Neurogenic locus notch homolog protein 3 [OS=Homo sapiens]",4,8,13,6,2321,243.5,5.39,17.82,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","NOTCH3","ENSG00000074181","Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; OSX and miRNAs in tooth development; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Neovascularisation processes; Osteoblast differentiation and related diseases; Notch signaling pathway","Pre-NOTCH Transcription and Translation; Pre-NOTCH Processing in Golgi; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Pre-NOTCH Processing in the Endoplasmic Reticulum; Defective LFNG causes SCDO3; Noncanonical activation of NOTCH3","Endocrine resistance; Notch signaling pathway; Apelin signaling pathway; Th1 and Th2 cell differentiation; Thyroid hormone signaling pathway; Human papillomavirus infection; Pathways in cancer; MicroRNAs in cancer; Breast cancer",304.6,323.1,323.8,352.3,331.8,343.6,0.9258538483993384,-0.11114362152146219,0.042529438933187724,1.3713103466494339,0.1771039249015092,0.7517718140545361,1875]
["Medium","Q9UN36-1","Protein NDRG2 [OS=Homo sapiens]",4,2,2,1,371,40.8,5.21,3.96,"cell-cell signaling;signal transduction;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","NDRG2","ENSG00000165795","","","",69.6,69.1,70.5,69,65.9,64.5,1.0491474423269809,0.06921744184874536,0.0786852806592518,1.1041065017748526,0.250356426808247,0.6014412555072026,2454]
["Low","Q9UNA0","A disintegrin and metalloproteinase with thrombospondin motifs 5 [OS=Homo sapiens]",1,1,1,1,930,101.7,8.85,0,"cell organization and biogenesis;protein metabolism;stress response;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;ER/Golgi","signal transduction activity or receptor binding;other molecular function","ADAMTS5","ENSG00000154736","Vitamin D receptor pathway; Endochondral ossification; IL-18 signaling pathway; Endochondral ossification with skeletal dysplasias","Degradation of the extracellular matrix; Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins","",235.2,372.9,373.3,263,408,316.8,0.9935209556590402,-0.009377697310217063,0.974398466196452,0.011263408334908298,0.9872960321907471,0.005552608353255,7706]
["High","Q9UNE7-1","E3 ubiquitin-protein ligase CHIP [OS=Homo sapiens]",29,8,13,8,303,34.8,5.87,33.16,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","STUB1","ENSCATG00000030791; ENSCSAG00000012299; ENSG00000103266; ENSGGOG00000043504; ENSMFAG00000031388; ENSMNEG00000033024; ENSPPAG00000028029; ENSPPYG00000006921; ENSPTRG00000007553; ENSRBIG00000029383; ENSRROG00000037882","Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway; Androgen receptor signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Downregulation of TGF-beta receptor signaling","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum",536.8,511.5,452.1,513.9,456.7,471,1.0407880133185352,0.05767625184793148,0.5544887457690479,0.2561072641225786,0.7437636363107244,0.12856505874882376,5821]
["High","Q9UNL2","Translocon-associated protein subunit gamma [OS=Homo sapiens]",15,4,14,4,185,21.1,9.61,35.32,"transport","other membranes;ER/Golgi","","SSR3","ENSG00000114850","VEGFA-VEGFR2 signaling pathway","SRP-dependent cotranslational protein targeting to membrane","Protein processing in endoplasmic reticulum",584.8,603,606.5,554.9,559.8,517.4,1.0993811653697692,0.13669166840645758,0.022600134789466854,1.6458889706690987,0.12695097297565267,0.8963639662645584,1390]
["High","Q9UNN8","Endothelial protein C receptor [OS=Homo sapiens]",5,1,3,1,238,26.7,7.18,4.91,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","PROCR","ENSG00000101000","","Cell surface interactions at the vascular wall; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",30.3,22.9,28.8,37.7,41.4,38.3,0.6984667802385008,-0.5177365936046062,0.00959886135977215,2.01778028097047,0.08120033531646907,1.0904421773377468,923]
["High","Q9UNY4-1","transcription termination factor 2 [OS=Homo sapiens]",27,25,46,25,1162,129.5,8.37,93.56,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","TTF2","ENSG00000116830","Thyroid stimulating hormone (TSH) signaling pathway; Thyroid hormones production and peripheral downstream signaling effects","","Thyroid hormone synthesis",1536.4,1640.8,1581.6,1700.7,1670.2,1683.4,0.9415349306531071,-0.08691347551764633,0.03525894118923353,1.4527307335164905,0.15840150334035405,0.8002407009705027,1738]
["High","Q9UPN9-1","E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",34,27,62,2,1127,122.5,6.67,131.34,"protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TRIM33","ENSG00000197323","Ectoderm differentiation","Downregulation of SMAD2/3:SMAD4 transcriptional activity","",2676.7,2671.4,2730.5,2825.6,2766.3,2800.2,0.9626434384718964,-0.0549265697208366,0.01492314649577096,1.8261395976623487,0.10079578532783708,0.9965576270882236,1156]
["High","Q9UPN9-2","Isoform Beta of E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",33,26,63,1,1110,120.5,6.67,137.02,"","","","TRIM33","","","","",161.2,178.2,159,179.3,181.5,154.5,0.9672035707354939,-0.04810852412902703,0.6223243038440229,0.20598323803330063,0.791256825340194,0.1016825307568333,6141]
["High","Q9UPT8","Zinc finger CCCH domain-containing protein 4 [OS=Homo sapiens]",18,15,42,14,1303,140.2,6.27,67.32,"other biological processes","cytosol;nucleus","other molecular function","ZC3H4","ENSG00000130749","","","",739.3,1054.1,1013.8,1307.1,1024,1127.4,0.8116813647535058,-0.30101460356959453,0.16748906773488215,0.7760135347606333,0.3842946344031618,0.4153356791978073,3403]
["High","Q9UPX8","SH3 and multiple ankyrin repeat domains protein 2 [OS=Homo sapiens]",5,7,7,7,1470,158.7,6.9,10.03,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","SHANK2","ENSG00000162105","","Neurexins and neuroligins","Glutamatergic synapse",309.3,323.3,320.1,375.1,311.3,312.2,0.9540356499098737,-0.06788491776849405,0.516710642554131,0.286752593312219,0.718773685562561,0.14340783087325593,5613]
["High","Q9UPY8","Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",10,3,7,1,281,32,5.54,11.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAPRE3","ENSG00000084764","","","",121.6,111.7,110.7,118.7,134.9,131.4,0.8935064935064935,-0.16244988088016585,0.08595030968650053,1.0657525541730195,0.263486461732311,0.5792416944779992,2547]
["High","Q9UQB3-1","Catenin delta-2 [OS=Homo sapiens]",3,3,3,3,1225,132.6,7.74,2.46,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","CTNND2","ENSG00000169862; ENSPTRG00000016731","Ectoderm differentiation; Ectoderm differentiation","","Wnt signaling pathway",50.5,44.4,43.4,44.2,48.1,48.6,0.9815471965933286,-0.026870455159142482,0.757294158248158,0.12073539330132793,0.8725029935962252,0.05923307428271798,6777]
["High","Q9Y217-1","Myotubularin-related protein 6 [OS=Homo sapiens]",8,4,6,4,621,71.9,7.66,13.34,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","MTMR6","ENSG00000139505; ENSPPAG00000035079","","Synthesis of PIPs at the plasma membrane","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system",209.3,193.9,197.5,231.8,215.4,233.3,0.8827332843497429,-0.17995049786488718,0.022693509493610885,1.6440983363825759,0.1272923291135875,0.8951977669984837,1392]
["High","Q9Y230","RuvB-like 2 [OS=Homo sapiens]",62,26,112,26,463,51.1,5.64,212.05,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","RUVBL2","ENSG00000183207","","HATs acetylate histones; Telomere Extension By Telomerase","",5186.4,5173.1,5123.9,4957.2,5298.5,4988.3,1.0157045394909472,0.022480794430016507,0.5105104569344135,0.29199535770556884,0.7135813905735591,0.1465564844119197,5586]
["High","Q9Y250","Leucine zipper putative tumor suppressor 1 [OS=Homo sapiens]",17,8,9,8,596,66.6,7.09,14.92,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;other cell component","cytoskeletal activity","LZTS1","ENSG00000061337","","","",348.1,354.2,339.6,454.7,340.2,348.4,0.9113093676200473,-0.13398719743007623,0.41401551080608673,0.3829833880305331,0.6399986355917492,0.19382095188424725,5051]
["High","Q9Y277","Voltage-dependent anion-selective channel protein 3 [OS=Homo sapiens]",51,12,51,10,283,30.6,8.66,130.66,"transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","VDAC3","ENSG00000078668","Alzheimer's disease and miRNA effects; Ferroptosis; Hepatitis B infection; Alzheimer's disease","Ub-specific processing proteases; Mitochondrial calcium ion transport","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Hepatitis B; Human T-cell leukemia virus 1 infection; Viral carcinogenesis; Chemical carcinogenesis; Diabetic cardiomyopathy",1792.8,1900,1892.5,1689.9,2199.8,2002.9,0.9478498455690187,-0.0772695634121577,0.5383991432134421,0.26889563990215226,0.7323729111865079,0.13526772764149042,5740]
["High","Q9Y282-1","Endoplasmic reticulum-Golgi intermediate compartment protein 3 [OS=Homo sapiens]",24,10,20,10,383,43.2,6.06,39.07,"transport","other membranes;ER/Golgi;other cell component","","ERGIC3","ENSCANG00000036642; ENSCATG00000041920; ENSG00000125991; ENSGGOG00000027615; ENSMFAG00000037850; ENSMLEG00000032774; ENSMNEG00000030061; ENSPANG00000011730; ENSPPAG00000037078; ENSPTRG00000013442; ENSRROG00000033106","","","",764.1,664.6,717.9,732.2,745.9,739.5,0.9679834054834056,-0.04694577985857626,0.46052552524428436,0.3367462934464533,0.6765349578753287,0.1697097576471335,5315]
["High","Q9Y2B1","UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase [OS=Homo sapiens]",5,2,2,2,443,51.1,8.32,4.19,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus","other molecular function","RXYLT1","ENSG00000118600","","","Mannose type O-glycan biosynthesis; Metabolic pathways",140.6,136.5,124.8,131.7,123.3,139.8,1.0179837892603851,0.025714587602347697,0.7423089265457141,0.12941531686044153,0.8642928867385828,0.06333906129460731,6706]
["High","Q9Y2F5","Little elongation complex subunit 1 [OS=Homo sapiens]",4,7,7,7,2266,247.7,5.48,11.53,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","ICE1","ENSG00000164151","","RNA polymerase II transcribes snRNA genes","",214.8,219.9,192.7,175.2,191.7,180.7,1.1457268078889704,0.19626308258570377,0.05110080343693105,1.2915722715779552,0.19693735105407584,0.7056719079435814,2026]
["High","Q9Y2G8","DnaJ homolog subfamily C member 16 [OS=Homo sapiens]",16,8,14,8,782,90.5,7.12,37.2,"","other membranes","","DNAJC16","ENSG00000116138","","","",502.4,503.2,502.2,470.6,453.3,486.1,1.0693617021276596,0.0967499144282934,0.026306640297218735,1.5799346134706593,0.13675249496716638,0.8640647414801735,1502]
["Medium","Q9Y2I8","WD repeat-containing protein 37 [OS=Homo sapiens]",1,1,1,1,494,54.6,7.23,2.3,"","nucleus;other cell component","","WDR37","ENSG00000047056","","","",87.6,98.5,95.9,123.8,92.6,99.7,0.8921227459664663,-0.16468587261834253,0.31904978836682496,0.4961415391191657,0.5561823504282584,0.25478279690521816,4479]
["High","Q9Y2J4","Angiomotin-like protein 2 [OS=Homo sapiens]",6,4,4,4,779,85.7,7.3,6.13,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","AMOTL2","ENSG00000114019","","Signaling by Hippo","Tight junction",188.1,198.7,174.9,164.7,135.5,160.4,1.2194963091619626,0.2862853917857648,0.04184233306877888,1.3783841078251113,0.17508303140462245,0.7567559425769571,1866]
["High","Q9Y2R0","Cytochrome c oxidase assembly factor 3 homolog, mitochondrial [OS=Homo sapiens]",26,3,6,3,106,11.7,9.6,12.73,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion","","COA3","ENSG00000183978","Mitochondrial complex IV assembly","","Thermogenesis",271.7,214.6,170.7,201.8,219.1,201.9,1.0549132947976878,0.07712442613065487,0.7215035451230167,0.14176153065006936,0.8518826070347066,0.06962024869541558,6613]
["High","Q9Y2R9","28S ribosomal protein S7, mitochondrial [OS=Homo sapiens]",17,3,5,3,242,28.1,9.99,8.48,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS7","ENSG00000125445","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",319,282.7,231.4,291,239.7,233.2,1.0905877732687523,0.12510588640567935,0.5020786987774817,0.2992282036398665,0.7082620560170871,0.14980602419597266,5535]
["High","Q9Y2V7-1","Conserved oligomeric Golgi complex subunit 6 [OS=Homo sapiens]",10,7,11,7,657,73.2,5.76,22.47,"other metabolic processes;transport","other membranes;ER/Golgi","","COG6","ENSG00000133103","","COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",545.7,502.7,493.5,453.7,555.3,503.2,1.0196402592249703,0.02806024261315656,0.7820151367286405,0.10678484063056012,0.8855655094383212,0.052779306483793316,6895]
["High","Q9Y2Y0","ADP-ribosylation factor-like protein 2-binding protein [OS=Homo sapiens]",34,5,13,5,163,18.8,4.35,32,"signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","ARL2BP","ENSG00000102931","Ciliopathies","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane","",451.1,439.3,470.8,415.8,399.3,366.9,1.1516074450084604,0.20364902090011378,0.024820332649068497,1.6051924022616744,0.1329198609903476,0.8764101215849948,1458]
["Low","Q9Y2Z2","Protein MTO1 homolog, mitochondrial [OS=Homo sapiens]",1,1,1,1,717,79.9,8.31,0,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","MTO1","ENSG00000135297","","tRNA modification in the mitochondrion","",10.6,17.6,18.4,18.4,15.4,18.1,0.8978805394990366,-0.15540458370360066,0.5421596894250633,0.2658727761525592,0.7346724843857853,0.13390622543831798,5762]
["High","Q9Y2Z4","Tyrosine--tRNA ligase, mitochondrial [OS=Homo sapiens]",45,17,69,17,477,53.2,8.98,146.02,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","YARS2","ENSG00000139131","Orexin receptor pathway","Mitochondrial tRNA aminoacylation","Aminoacyl-tRNA biosynthesis",2448.5,2399.6,2466.3,2482.8,2645.9,2555.6,0.9518628892677277,-0.07117431885359478,0.07375220704059772,1.1322249788588012,0.24144957340586456,0.6171735575762987,2385]
["Medium","Q9Y2Z9-1","Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [OS=Homo sapiens]",2,1,1,1,468,50.8,7.3,0,"other metabolic processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","COQ6","ENSG00000119723","Nephrotic syndrome","Ubiquinol biosynthesis","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors",36.4,33.6,37.7,41.1,45.2,42.8,0.8342370255615801,-0.2614707507629833,0.013641081959921687,1.8651511816892024,0.0961277689016864,1.017151137422978,1108]
["High","Q9Y303","N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",16,5,6,5,409,43.7,6.7,13.48,"other metabolic processes","cytosol","other molecular function","AMDHD2","ENSG00000162066","","Synthesis of UDP-N-acetyl-glucosamine","Amino sugar and nucleotide sugar metabolism; Metabolic pathways",177.9,168.3,187.6,208.8,215.4,176.8,0.8881863560732114,-0.17106568545658124,0.16388899833812368,0.785450199092163,0.3797167059418604,0.42054029530486625,3370]
["High","Q9Y305-1","Acyl-coenzyme A thioesterase 9, mitochondrial [OS=Homo sapiens]",31,12,33,12,439,49.9,8.6,73.44,"other metabolic processes","mitochondrion","other molecular function","ACOT9","ENSG00000123130","VEGFA-VEGFR2 signaling pathway","Mitochondrial Fatty Acid Beta-Oxidation","",1227.1,1135.3,1199.9,1140.4,1213.4,1196.2,1.0034647887323942,0.004989993868033222,0.912449799415411,0.03979101995269768,0.9583545915840099,0.01847377205376935,7434]
["High","Q9Y312","Protein AAR2 homolog [OS=Homo sapiens]",29,8,27,8,384,43.4,5.96,31.97,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","","AAR2","ENSG00000131043","Ciliary landscape","","",468.6,487.6,465.4,418.8,379.8,402.4,1.1836802664446293,0.24327943543568153,5.1716424699483595E-3,2.2863715067413066,0.06072208181256661,1.2166533473857757,665]
["High","Q9Y314","nitric oxide synthase-interacting protein [OS=Homo sapiens]",47,9,14,9,301,33.2,8.82,34.49,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","NOSIP","ENSG00000142546","","NOSIP mediated eNOS trafficking","",533.2,553.2,512.3,493.9,478.2,470.3,1.108361064891847,0.14842793704884905,0.019028634296399734,1.720592380332071,0.1152642176774935,0.9383054930268387,1289]
["High","Q9Y315","deoxyribose-phosphate aldolase [OS=Homo sapiens]",31,9,19,9,318,35.2,8.94,32.66,"other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","DERA","ENSG00000023697","Pentose phosphate pathway in senescent cells","Neutrophil degranulation; Pentose phosphate pathway","Pentose phosphate pathway; Metabolic pathways",752.9,763,708.4,704.3,767.4,756.5,0.9982497082847144,-0.002527349623086089,0.9620822434562224,0.01678780077663843,0.9822094870431727,0.00779587538604668,7648]
["High","Q9Y316-1","Protein MEMO1 [OS=Homo sapiens]",21,5,11,5,297,33.7,7.14,22.28,"other biological processes","","other molecular function","LOC111154137; LOC114499315; MEMO1","ENSANAG00000021250; ENSCANG00000020056; ENSCATG00000030724; ENSCCAG00000037443; ENSCHIG00000006439; ENSCJAG00000003208; ENSDLEG00000015222; ENSECAG00000019946; ENSFCAG00000001385; ENSG00000162959; ENSHGLG00000018935; ENSMMUG00000003908; ENSMNEG00000040106; ENSMODG00000047380; ENSPANG00000022798; ENSPCOG00000018130; ENSPCTG00005009736; ENSPTRG00000050445; ENSRFEG00010015180; ENSSSCG00000008515; ENSSSCG00070008027; ENSVURG00010020209; ENSVVUG00000007616","","ERBB2 Regulates Cell Motility; ERBB2 Regulates Cell Motility","",554.1,544.3,551.3,587.9,533.6,570,0.975288205734555,-0.03609948469915272,0.439256100064156,0.35728219862991983,0.6591796327697348,0.180996219867321,5203]
["High","Q9Y320","Thioredoxin-related transmembrane protein 2 [OS=Homo sapiens]",29,7,29,7,296,34,8.69,56.44,"developmental processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","TMX2","ENSG00000213593","","","",1374,1351.3,1397.4,1353.1,1503.5,1405.1,0.9673839078302088,-0.04783955574597935,0.37140212160337527,0.43015561971845984,0.6047774276286035,0.21840442656650688,4795]
["High","Q9Y324","rRNA-processing protein FCF1 homolog [OS=Homo sapiens]",10,2,3,2,198,23.4,9.7,7.51,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","FCF1","ENSG00000119616","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",130.7,121,114.3,112.3,112.1,111.1,1.090909090909091,0.12553088208385912,0.10030690657620292,0.998669162845311,0.28417863807946026,0.5464085714222638,2756]
["High","Q9Y333","U6 snRNA-associated Sm-like protein LSm2 [OS=Homo sapiens]",67,5,22,5,95,10.8,6.52,32.21,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM2","ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826","mRNA processing","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",666.6,626.8,670.2,605.4,915.7,753.1,0.8634245009234018,-0.21185806294140283,0.3172801838596239,0.49855705147085466,0.5542111131042379,0.2563247699441558,4470]
["High","Q9Y365","START domain-containing protein 10 [OS=Homo sapiens]",4,1,1,1,291,33,7.12,3.13,"transport","other membranes;cytosol;cytoskeleton;other cell component","other molecular function","STARD10","ENSG00000214530","","Synthesis of PC","",16.6,14.2,11.1,15.4,14.9,14.1,0.9436936936936938,-0.08360943265075417,0.6373840586863861,0.19559880266196109,0.8001116929619458,0.09684938269414439,6220]
["High","Q9Y366","Intraflagellar transport protein 52 homolog [OS=Homo sapiens]",9,2,4,2,437,49.7,5.26,10.33,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","IFT52","ENSG00000101052","Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies","Intraflagellar transport; Hedgehog 'off' state","",46,42,46.2,38.8,39.6,38.4,1.1489726027397258,0.20034439732016598,0.014782972918332212,1.8302382187021486,0.10028275633912938,0.998773737673305,1151]
["High","Q9Y371","Endophilin-B1 [OS=Homo sapiens]",36,11,39,10,365,40.8,6.04,80.37,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GLB1","ENSG00000097033","Nanoparticle triggered autophagic cell death","","Autophagy; Endocytosis",1924.9,1896,1945.5,2033.9,1987.2,2004.3,0.9570153018886711,-0.06338610248284006,0.01206706162215064,1.9183984694754292,0.0902486754269657,1.0445591634830373,1044]
["High","Q9Y375","Complex I intermediate-associated protein 30, mitochondrial [OS=Homo sapiens]",33,9,17,9,327,37.7,7.64,48.38,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion","other molecular function","NDUFAF1","ENSG00000137806","Mitochondrial immune response to SARS-CoV-2","Complex I biogenesis","Thermogenesis",698.4,699.7,713.6,641,628.4,629.4,1.1121234463871918,0.1533169369875868,3.5950631842456113E-4,3.444293472366475,0.018467271935914298,1.7335972556526118,152]
["High","Q9Y376","Calcium-binding protein 39 [OS=Homo sapiens]",36,13,28,12,341,39.8,6.89,47.44,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CAB39","ENSG00000135932","AMP-activated protein kinase (AMPK) signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias","Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK","mTOR signaling pathway; AMPK signaling pathway",1665.9,1648.4,1619.1,1482.3,1566.7,1514.2,1.0811272791023843,0.11253637887319573,0.0118248455816831,1.9272045219187608,0.0890341314385551,1.0504434736491666,1037]
["High","Q9Y383","Putative RNA-binding protein Luc7-like 2 [OS=Homo sapiens]",41,19,111,13,392,46.5,10.01,244.56,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","LUC7L2","ENSG00000146963","","","",5158,5272,5172.9,5251.5,4803.1,5112.2,1.0287535933750034,0.04089746990351675,0.349238749418596,0.45687757560496844,0.5860425866022776,0.23207082347960042,4653]
["High","Q9Y388","RNA-binding motif protein, X-linked 2 [OS=Homo sapiens]",10,4,10,4,322,37.3,9.83,19.58,"RNA metabolism OR transcription;other metabolic processes","nucleus","","RBMX2","ENSG00000134597","","","",544.6,480.5,534.4,593.6,600.6,585.1,0.876468274040353,-0.19022622491000588,0.02287560347356027,1.6406274401345118,0.12739851064305177,0.8948356491065163,1402]
["High","Q9Y394","Dehydrogenase/reductase SDR family member 7 [OS=Homo sapiens]",9,2,3,2,339,38.3,8.32,2.66,"","","other molecular function","DHRS7","ENSG00000100612","","","",141.5,115.2,125.4,117.6,101.1,133.2,1.0858198351804491,0.11878474360784667,0.4494630682290384,0.3473059878535106,0.6676955168821027,0.17542153974659955,5256]
["High","Q9Y399","28S ribosomal protein S2, mitochondrial [OS=Homo sapiens]",18,6,9,6,296,33.2,9.26,9.57,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS2","ENSG00000122140","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",335.1,353.1,354.5,353,377.8,342,0.9719425801640568,-0.04105700920392052,0.460201639494797,0.3370518384655607,0.6763136459957415,0.16985184971666253,5313]
["High","Q9Y3A3","MOB-like protein phocein [OS=Homo sapiens]",46,7,35,7,225,26,5.78,49.95,"","other membranes;ER/Golgi;other cell component","other molecular function","MOB4","ENSG00000115540","","","",844.1,782.1,756.6,772.4,925.9,797.8,0.9546091903369257,-0.06701786913030339,0.5238903885835768,0.28075956914778943,0.7229650325310301,0.14088270761012603,5658]
["High","Q9Y3A4","Ribosomal RNA-processing protein 7 homolog A [OS=Homo sapiens]",29,7,16,7,280,32.3,9.58,27.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","","RRP7A","ENSG00000189306","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",823.2,725.1,711.7,866.3,783.4,707.9,0.9586019681031558,-0.06099619293408773,0.6028936295415228,0.2197593050707573,0.7769258061495644,0.10962045290865166,6059]
["High","Q9Y3A5","Ribosome maturation protein SBDS [OS=Homo sapiens]",61,20,70,20,250,28.7,8.75,104.87,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity","SBDS","ENSG00000126524","","","Ribosome biogenesis in eukaryotes",4007.8,3869.2,3691.6,3269.7,3450.3,3262.6,1.158876445014325,0.21272675990171372,0.008667721654215544,2.06209504358886,0.07796955147017853,1.1080749641067165,868]
["High","Q9Y3A6-1","Transmembrane emp24 domain-containing protein 5 [OS=Homo sapiens]",12,3,5,3,229,26,4.84,9.42,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED5","ENSG00000117500","","WNT ligand biogenesis and trafficking","",218,213.7,224.6,200.8,214,228.5,1.0202083009482357,0.028863744416532555,0.6410000512469926,0.19314193575998884,0.8031014762735106,0.09522957576586147,6232]
["High","Q9Y3B2","Exosome complex component csl4 [OS=Homo sapiens]",24,3,8,3,195,21.4,8.24,24.08,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EXOSC1","ENSG00000171311","","Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","RNA degradation",241.7,229.8,218.4,226.1,336.5,297.7,0.8019295594560037,-0.31845257726782267,0.16059105651992733,0.7942786446874588,0.3765450358281059,0.4241830735351433,3330]
["High","Q9Y3B3-1","Transmembrane emp24 domain-containing protein 7 [OS=Homo sapiens]",25,5,15,5,224,25.2,6.89,25.06,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED7","ENSG00000134970; ENSPTRG00000017152","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",703.4,718.9,734,587.8,822.7,773.1,0.9874977102033341,-0.018150692008613415,0.9055560934420606,0.04308464273497468,0.9549678521874134,0.02001124815720578,7404]
["High","Q9Y3B4","Splicing factor 3B subunit 6 [OS=Homo sapiens]",34,4,4,4,125,14.6,9.38,8.97,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","SF3B6","ENSG00000115128","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","Spliceosome",251.3,221.3,202.9,302.4,227.9,210.3,0.9120982986767486,-0.1327387799585829,0.5294570154246411,0.276169292821189,0.7251360070927202,0.13958052916668556,5701]
["High","Q9Y3B6","ER membrane protein complex subunit 9 [OS=Homo sapiens]",8,1,1,1,208,23,5.91,3.52,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC9","ENSG00000100908; ENSG00000285377","","","",19.7,19.4,26.4,24.6,17.1,18.3,1.0916666666666666,0.1265324059289316,0.6039417284031328,0.2190049624613388,0.7777629911548178,0.10915272603766983,6063]
["High","Q9Y3B7-1","39S ribosomal protein L11, mitochondrial [OS=Homo sapiens]",43,9,19,9,192,20.7,9.91,33.13,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL11","ENSG00000174547; ENSPPAG00000028194; ENSPTRG00000003924","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",963.3,924.9,944.8,899.6,984.1,988.8,0.9862489120974761,-0.019976291155377007,0.693161055528176,0.15916584561815264,0.8352162841919749,0.07820104683011062,6480]
["High","Q9Y3B8-1","Oligoribonuclease, mitochondrial [OS=Homo sapiens]",34,6,27,6,237,26.8,6.87,49.9,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","REXO2","ENSG00000076043; ENSPPAG00000039849; ENSPTRG00000004306","","","Ribosome biogenesis in eukaryotes",1141.8,1063.1,878.9,1286.3,1023.5,1028.2,0.9238466147393647,-0.11427475247109954,0.507836203461424,0.2942763416602747,0.7125220263480321,0.14720170567236646,5565]
["High","Q9Y3B9","RRP15-like protein [OS=Homo sapiens]",18,5,23,5,282,31.5,5.52,39.06,"RNA metabolism OR transcription;other metabolic processes","other cell component","","RRP15","ENSG00000067533","","","",1005.4,993.5,934.5,1208.6,1025.6,1004.2,0.9058176877470357,-0.1427073839650164,0.2117372118172302,0.6742028100641893,0.44016084927287896,0.3563885889996272,3756]
["High","Q9Y3C0","WASH complex subunit 3 [OS=Homo sapiens]",17,2,2,2,194,21.2,4.46,0,"cell organization and biogenesis;transport","other cytoplasmic organelle;other cell component","","WASHC3","ENSG00000120860","","","Endocytosis",26.7,19.1,23.7,24,18.1,23.1,1.0659509202453987,0.09214101337979216,0.6440034272681086,0.19111182139846908,0.8049269665614522,0.09424352268585537,6247]
["High","Q9Y3C1","nucleolar protein 16 [OS=Homo sapiens]",17,3,6,3,178,21.2,9.94,8.83,"other biological processes","nucleus;other cell component","","NOP16","ENSG00000048162","","","",265.2,277.6,283.1,410.1,273.7,258.7,0.876286472148541,-0.1905255077266717,0.4674040572569257,0.3303075220750567,0.6824029317617942,0.1659591160063681,5348]
["High","Q9Y3C4","EKC/KEOPS complex subunit TPRKB [OS=Homo sapiens]",14,2,9,2,175,19.6,6.79,12.12,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","TPRKB","ENSG00000144034","","tRNA modification in the nucleus and cytosol","",208.4,230.9,231.9,229,231.6,235.3,0.9645063945969248,-0.05213729163352289,0.35545109461248797,0.44922014402279853,0.5915094089374053,0.2280383428076548,4692]
["High","Q9Y3C5","Ring finger protein 11 [OS=Homo sapiens]",8,1,2,1,154,17.4,4.78,3.26,"protein metabolism;other metabolic processes","nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","RNF11","ENSG00000123091","","","",68.8,53,60.3,56.6,52.1,50.1,1.1467254408060452,0.19752000983388032,0.19197828541803932,0.7167478913820935,0.414881387363424,0.38207604829148034,3613]
["High","Q9Y3C6","Peptidyl-prolyl cis-trans isomerase-like 1 [OS=Homo sapiens]",40,6,42,6,166,18.2,7.99,66.58,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","PPIL1","ENSG00000137168","","mRNA Splicing - Major Pathway","Spliceosome",2405.5,2227.7,2159.8,2439.8,2294.7,2322.2,0.962631258236853,-0.054944824118221214,0.36307095879469803,0.4400084879078644,0.5981975197866642,0.22315539194863018,4739]
["High","Q9Y3C8","ubiquitin-fold modifier-conjugating enzyme 1 [OS=Homo sapiens]",26,5,12,5,167,19.4,7.4,25.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes","","other molecular function","UFC1","ENSG00000143222","","","",508.7,487.4,478.8,535.4,529.7,482,0.9533320405920755,-0.06894931004546308,0.27660743474219934,0.5581361509652553,0.5119106068895691,0.29080587168850086,4219]
["High","Q9Y3D0","Mitotic spindle-associated MMXD complex subunit MIP18 [OS=Homo sapiens]",26,2,2,2,163,17.7,5.19,7.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CIAO2B","ENSG00000166595","","Cytosolic iron-sulfur cluster assembly","",71.8,58.1,48.7,62.7,38.3,34.6,1.3171091445427732,0.3973749019848793,0.2653056369698903,0.5762535224303723,0.5010900855009442,0.30008419006300635,4134]
["High","Q9Y3D2","Methionine-R-sulfoxide reductase B2, mitochondrial [OS=Homo sapiens]",21,2,3,2,182,19.5,8.63,5.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","MSRB2","ENSG00000148450","Sulindac metabolic pathway; Methionine de novo and salvage pathway","Protein repair","",45.3,37.2,40.6,31.4,25.4,36.3,1.322234156820623,0.40297768892566377,0.06369615224540878,1.1958868017158,0.22054969256414714,0.656493543271144,2255]
["High","Q9Y3D3","28S ribosomal protein S16, mitochondrial [OS=Homo sapiens]",23,2,4,2,137,15.3,9.5,7.77,"protein metabolism;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","other molecular function","MRPS16","ENSG00000182180","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Ribosome",102.3,87.4,87.8,93.9,83.2,79.8,1.0801868431296224,0.11128088122401379,0.34945178571253405,0.4566127359223979,0.5861481295045039,0.23199261658112397,4655]
["High","Q9Y3D6","mitochondrial fission 1 protein [OS=Homo sapiens]",12,2,9,2,152,16.9,8.79,17.75,"cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FIS1","ENSG00000214253","CAMKK2 pathway","Class I peroxisomal membrane protein import","Mitophagy",383.1,367.2,341.8,266,300.8,312.1,1.2425759472067357,0.31333403312357594,0.01798220516950101,1.7451570515225734,0.1117874665314203,0.9516068862651152,1256]
["High","Q9Y3D8","Adenylate kinase isoenzyme 6 [OS=Homo sapiens]",56,5,10,5,172,20,4.58,15.84,"other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AK6","ENSG00000085231; ENSG00000279247","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Metabolic pathways; Biosynthesis of cofactors; Ribosome biogenesis in eukaryotes",259.8,256.6,221,268.6,292.7,259.7,0.8981729598051158,-0.15493480557134917,0.15389833935520425,0.8127660664112912,0.3679235253170346,0.4342424421533051,3266]
["High","Q9Y3D9","28S ribosomal protein S23, mitochondrial [OS=Homo sapiens]",11,2,3,2,190,21.8,8.9,7.9,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS23","ENSG00000181610","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",207.6,183.9,178.7,243,214.6,198,0.8697376449054303,-0.201347815161506,0.1472273981817167,0.8320113627437089,0.360360979624716,0.4432622411422546,3190]
["High","Q9Y3E0","vesicle transport protein GOT1B [OS=Homo sapiens]",17,3,44,3,138,15.4,10.36,91.96,"transport","other membranes;ER/Golgi;other cell component","","GOLT1B","ENSG00000111711","","","",2487,2485,2454.3,2581.7,2585.7,2482.8,0.9707327912995739,-0.042853867955075904,0.10184674102269273,0.992052863359996,0.2865655329388053,0.5427760461600557,2775]
["High","Q9Y3E1","Hepatoma-derived growth factor-related protein 3 [OS=Homo sapiens]",30,5,21,4,203,22.6,7.99,36.17,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","HDGFL3","ENSG00000166503","","","",701.2,715.9,698.5,706.2,749.3,733.1,0.9666453440555606,-0.04894142361671777,0.1499591259572548,0.8240270995458151,0.36272641123737465,0.4404208209372126,3228]
["High","Q9Y3E5","Peptidyl-tRNA hydrolase 2, mitochondrial [OS=Homo sapiens]",21,2,5,2,179,19.2,8.73,12.87,"other biological processes","cytosol;mitochondrion","other molecular function","PTRH2","ENSG00000141378","Apoptosis modulation and signaling","Ub-specific processing proteases","",158.7,158.9,166.9,142.9,143.2,139,1.1397318278052222,0.1886944066632686,0.002800618427137902,2.5527460580014716,0.04565183440311636,1.3405417667573996,479]
["High","Q9Y3E7","Charged multivesicular body protein 3 [OS=Homo sapiens]",9,2,4,2,222,25.1,5.12,5.58,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","CHMP3","ENSG00000115561","","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","Endocytosis; Necroptosis",62.6,64.4,68.5,68.2,74.9,74.1,0.9000920810313076,-0.1518554956096469,0.057623414316059246,1.2394010123747141,0.21083581020608744,0.6760556228045299,2134]
["High","Q9Y3F4","Serine-threonine kinase receptor-associated protein [OS=Homo sapiens]",68,21,239,21,350,38.4,5.12,565.03,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","STRAP","ENSG00000023734","TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer","Downregulation of TGF-beta receptor signaling","",8764.3,8482.3,8598.4,8540.5,8463,8673.1,1.0065585007360787,0.009431023495391056,0.6122836644614684,0.2130473272519708,0.7833378423914708,0.10605089254992842,6103]
["High","Q9Y3I0","tRNA-splicing ligase RtcB homolog [OS=Homo sapiens]",56,25,115,25,505,55.2,7.23,254.71,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","RTCB","ENSG00000100220","Unfolded protein response","tRNA processing in the nucleus","",5734.9,5813.4,5696.9,5732.9,5701.4,5797.7,1.0007660167130916,1.1047054557919804E-3,0.9259922975120198,0.03339262580396124,0.96427685502452,0.015798257230857718,7498]
["High","Q9Y3L3-1","SH3 domain-binding protein 1 [OS=Homo sapiens]",15,8,16,8,701,75.7,6.77,35.16,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SH3BP1","ENSG00000100092","","RAC1 GTPase cycle","",591.5,594.1,605,662.6,614.5,642.8,0.9326527423303298,-0.10058807723307835,0.041523243825204816,1.38170872644192,0.17458992341798557,0.757980825523065,1857]
["High","Q9Y3M8-4","Isoform 4 of StAR-related lipid transfer protein 13 [OS=Homo sapiens]",3,3,3,2,1078,120.6,6.95,8.94,"","","","STARD13","","","","",132.4,123,122,106.2,97.6,128.3,1.136404697380307,0.1844767000977368,0.1954528641354888,0.7089579611021646,0.4184524165533031,0.3783539197573105,3647]
["High","Q9Y3P9","Rab GTPase-activating protein 1 [OS=Homo sapiens]",26,22,38,20,1069,121.7,5.25,80,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity;other molecular function","RABGAP1","ENSG00000011454","","TBC/RABGAPs","",1288.5,1403.1,1403.2,1221.1,1181,1205,1.1352055667988137,0.1829535691881197,0.015236231086285117,1.8171224490632445,0.10176603278162034,0.9923971555664493,1169]
["High","Q9Y3Q3","Transmembrane emp24 domain-containing protein 3 [OS=Homo sapiens]",9,2,7,2,217,24.8,5.6,19.2,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED3","ENSG00000166557","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",403.5,402.8,410.7,420.9,499.5,430.6,0.9008142116950408,-0.15069850661195597,0.14692931650886776,0.832891541665492,0.3599699100411796,0.4437338004805892,3187]
["High","Q9Y3Q4","Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [OS=Homo sapiens]",2,2,2,2,1203,129,8.91,2.14,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","HCN4","ENSG00000138622","Genes targeted by miRNAs in adipocytes","HCN channels","cAMP signaling pathway; Taste transduction",31.9,51.9,41,43.1,39.3,44.6,0.9826771653543307,-0.02521056279727988,0.9085051728551886,0.041672595558953605,0.9569146620333621,0.019126791022060025,7413]
["High","Q9Y3R0","Glutamate receptor-interacting protein 1 [OS=Homo sapiens]",4,3,4,3,1128,122.3,6.47,2.15,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","GRIP1","ENSG00000155974","Brain-derived neurotrophic factor (BDNF) signaling pathway; Fragile X syndrome; 7q11.23 copy number variation syndrome; Development of ureteric collection system","Trafficking of GluR2-containing AMPA receptors","",18.7,14.7,21,17.5,15.4,18,1.068762278978389,0.09594099517464419,0.5919633293777607,0.22770519588207885,0.7693158581527224,0.1138953152195554,6008]
["High","Q9Y3R5-1","Protein dopey-2 [OS=Homo sapiens]",3,5,5,5,2298,258.1,6.29,4.3,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","DOP1B","ENSG00000142197","","","",116,117.9,108,87.1,106.9,88,1.2124113475177303,0.27787926014723835,0.04883980989478298,1.3112260351818523,0.19143636328236222,0.717975564610897,1992]
["High","Q9Y3S1-1","Serine/threonine-protein kinase WNK2 [OS=Homo sapiens]",12,25,42,17,2297,242.5,6.13,74.88,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","WNK2","ENSG00000165238","","Stimuli-sensing channels","",1702.5,1811.9,1861.5,1733.5,1775,1722.4,1.0277198952379132,0.03944711198739142,0.3851935637614436,0.4143209781576847,0.6154269175054945,0.21082351252722115,4887]
["High","Q9Y3S2","zinc finger protein 330 [OS=Homo sapiens]",24,7,19,7,320,36.2,6.16,30.55,"","nucleus;other cell component","other molecular function","ZNF330","ENSG00000109445","","","",674.9,665.7,646.7,686,648.6,631.6,{"$f":"AVERAGE(T7618:V7618)/AVERAGE(W7618:Y7618)","v":1.0107313599837249},{"$f":"LOG(Z7618,2)","v":0.015399597518079622},{"$f":"TTEST(T7618:V7618,W7618:Y7618,2,2)","v":0.7171796534146149},{"$f":"-LOG10(AB7618)","v":0.14437203998980852},{"$f":"AB7618*7808/AF7618","v":0.8498616988710446},{"$f":"-LOG10(AD7618)","v":0.07065174287870957},6589]
["High","Q9Y3T6","R3H and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",10,4,5,4,440,49.1,5.63,11.19,"","","nucleic acid binding activity","R3HCC1","ENSG00000104679","","","",205,191.5,187.9,195.5,242.6,179.7,0.9459371965037229,-0.08018369282413938,0.6003130240427048,0.22162223434107642,0.7755202004840236,0.11040688534942884,6044]
["High","Q9Y3T9","Nucleolar complex protein 2 homolog [OS=Homo sapiens]",27,18,61,18,749,84.9,5.62,100.48,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","other molecular function","NOC2L","ENSG00000188976","","Regulation of TP53 Activity through Phosphorylation","",2370.2,2679.5,2620.9,2497.6,2806.9,2703.2,0.9579030183448433,-0.06204849533036114,0.4405671072206177,0.3559879304395233,0.6597522004561917,0.180619152613198,5214]
["High","Q9Y3U8","60S ribosomal protein L36 [OS=Homo sapiens]",21,2,9,2,105,12.2,11.59,23.05,"protein metabolism;other metabolic processes","cytosol;translational apparatus;nucleus","other molecular function","RPL36","ENSG00000130255","Cytoplasmic ribosomal proteins","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Ribosome; Coronavirus disease",501.3,462.9,401.7,454.2,397.3,369.8,1.118398427904692,0.16143423787918906,0.2755212767979104,0.5598448576502119,0.5111119337700367,0.2914839787395988,4209]
["High","Q9Y3X0","coiled-coil domain-containing protein 9 [OS=Homo sapiens]",11,5,7,5,531,59.7,5.4,15.69,"","","","CCDC9","ENSG00000105321","IL-18 signaling pathway","","",207.4,263.9,232.5,375.9,273.4,202.5,0.8262502934961258,-0.275349215800673,0.4039901860272796,0.3936291849041649,0.6312498243948368,0.19979872968811624,4997]
["High","Q9Y3Z3","deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [OS=Homo sapiens]",40,24,80,24,626,72.2,7.14,136.63,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMHD1","ENSG00000101347","","Interferon alpha/beta signaling; Nucleotide catabolism","Human immunodeficiency virus 1 infection",3029,3057.3,3079.1,2893.3,2852.4,2808.5,1.0714502817329499,0.09956490651330784,0.002014776025997511,2.6957732254929723,0.0398262562303508,1.399830516460797,395]
["High","Q9Y426","C2 domain-containing protein 2 [OS=Homo sapiens]",10,4,6,4,696,75.5,6.92,13.35,"","other membranes","","C2CD2","ENSG00000157617","","","",121.7,134.3,130.2,135.8,158.7,137.3,0.8943955534969892,-0.16101507907185522,0.14009343859466297,0.8535822048203051,0.3490266651394794,0.45714139229424106,3134]
["Low","Q9Y448","Small kinetochore-associated protein [OS=Homo sapiens]",2,1,1,1,316,35.4,6.3,1.83,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KNSTRN","ENSG00000128944","Leukocyte-intrinsic Hippo pathway functions","","",80.2,72.7,70.9,120.7,78.4,68.1,0.8375748502994012,-0.25570997149765834,0.4260780025711714,0.37051088684756633,0.6476186575969839,0.18868064791326816,5137]
["High","Q9Y450-1","HBS1-like protein [OS=Homo sapiens]",28,15,37,15,684,75.4,6.61,87.73,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol","nucleic acid binding activity;other molecular function","HBS1L","ENSG00000112339","","mRNA decay by 3' to 5' exoribonuclease","mRNA surveillance pathway; Legionellosis",1394.8,1450.3,1391.4,1412.7,1355.3,1368.1,1.0242740746113488,0.03460180242448738,0.2647960050775066,0.5770885712938257,0.5008544592163691,0.3002884552543453,4128]
["Medium","Q9Y458-1","T-box transcription factor TBX22 [OS=Homo sapiens]",2,1,2,1,520,57.9,7.33,2.14,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TBX22","ENSG00000122145; ENSG00000277800","","","",58.9,64.9,57,71.9,45.8,53.6,1.0554582603619382,0.0778695263311889,0.715537928019158,0.14536734094981751,0.8493341656998459,0.070921405437818,6578]
["High","Q9Y462","Zinc finger protein 711 [OS=Homo sapiens]",4,2,2,2,761,86.2,6.87,0,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF711","ENSG00000147180","","Generic Transcription Pathway","",33.5,38,38.9,41.9,37.1,41.2,0.91846921797005,-0.12269672393301627,0.21900635834834842,0.6595432762305851,0.4485838525666066,0.34815636353823853,3812]
["High","Q9Y467","sal-like protein 2 [OS=Homo sapiens]",24,14,35,13,1007,105.2,6.3,102.72,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SALL2","ENSG00000165821","","","",1362.2,1402.7,1464,1683.9,1577.8,1593,0.8710939913897872,-0.19909970029287485,0.009333561743864252,2.029952595211079,0.08026040759481508,1.0954986390735286,908]
["High","Q9Y467-3","Isoform 2 of Sal-like protein 2 [OS=Homo sapiens]",13,1,3,1,198,20.9,4.77,9.61,"","","","SALL2","","","","",70,68.2,62.6,87,60.7,70,0.9223702342673403,-0.11658213823743474,0.5209382092476712,0.2832137872076483,0.7213132714676036,0.14187607713736605,5639]
["High","Q9Y478","5'-AMP-activated protein kinase subunit beta-1 [OS=Homo sapiens]",11,2,2,2,270,30.4,6.4,5.7,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","PRKAB1","ENSG00000111725","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma","Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy",114.8,128.5,130.8,126,117.5,125.9,1.0127233351380618,0.01824009956838817,0.7982047903021305,0.09788567019326425,0.8955860041211432,0.047892702029643776,6959]
["High","Q9Y483","Metal-response element-binding transcription factor 2 [OS=Homo sapiens]",9,4,4,4,593,67.1,8.72,8.81,"","","","","","","","",180.2,211.5,176.4,213,210.3,221.6,0.880911769266553,-0.182930566565703,0.09254966997866436,1.0336251255518174,0.2737226603005346,0.5626892477630131,2640]
["High","Q9Y484-1","WD repeat domain phosphoinositide-interacting protein 4 [OS=Homo sapiens]",3,1,1,1,360,39.8,7.14,2.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;other cell component","other molecular function","WDR45","ENSCANG00000035794; ENSCSAG00000012964; ENSG00000196998; ENSGGOG00000000589; ENSMFAG00000032970; ENSMLEG00000042347; ENSMMUG00000010620","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway","Macroautophagy","",90.5,82.6,85,94.7,82.7,91.3,0.9605508001488651,-0.05806617991919596,0.45431456071166804,0.34264334389109014,0.6717076481796448,0.1728197067209495,5281]
["High","Q9Y485","DmX-like protein 1 [OS=Homo sapiens]",5,10,10,9,3027,337.6,6.34,18.22,"other biological processes","other cell component","","DMXL1","ENSG00000172869","","","Lysosome",358.9,334.9,360,364.7,410.9,380.2,0.9117494376189652,-0.1332906902021252,0.0985836002548468,1.006195325537529,0.2823700479786661,0.5491813723775485,2726]
["High","Q9Y487","V-type proton ATPase 116 kDa subunit a isoform 2 [OS=Homo sapiens]",20,13,19,12,856,98,6.61,26.08,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V0A2","ENSG00000185344","","Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; ROS and RNS production in phagocytes","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Human papillomavirus infection; Rheumatoid arthritis",526.8,523.2,509.5,519.2,554.5,495.3,0.9939451880178458,-0.008761799593945487,0.8687870271373224,0.06108667265939422,0.9360409973628002,0.028705129319037057,7247]
["High","Q9Y490","Talin-1 [OS=Homo sapiens]",61,118,456,100,2541,269.6,6.07,1103.31,"cell adhesion;cell organization and biogenesis;signal transduction","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN1","ENSG00000137076","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion","Signaling by BRAF and RAF1 fusions; p130Cas linkage to MAPK signaling for integrins; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Platelet degranulation ; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection",18464.3,18391.9,18791.4,18608.7,18607.5,18838.2,0.9927427641719473,-0.010508154505326796,0.40223542563198056,0.3955196829213571,0.6296419814223143,0.20090632306922673,4988]
["High","Q9Y496","kinesin-like protein KIF3A [OS=Homo sapiens]",11,7,8,7,699,80,6.54,14.44,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3A","ENSG00000131437","Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO","Hedgehog signaling pathway",365,344.4,331.7,346.4,326.4,315.2,1.053744939271255,0.0755257024785834,0.2546275186674631,0.5940946621136409,0.48932603144365044,0.31040167978141714,4063]
["High","Q9Y4A5","Transformation/transcription domain-associated protein [OS=Homo sapiens]",15,43,73,43,3859,437.3,8.19,147.48,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus","other molecular function","TRRAP","ENSG00000196367","Rett syndrome causing genes","Ub-specific processing proteases; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex","Human T-cell leukemia virus 1 infection",2507,2481.6,2562.9,2393.3,2543,2515,1.0134473179176786,0.019271095065947503,0.5545193842889302,0.25608326765264966,0.7436769757004409,0.12861566409680628,5822]
["High","Q9Y4A8","nuclear factor erythroid 2-related factor 3 [OS=Homo sapiens]",2,1,1,1,694,76.1,5.44,3.21,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFE2L3","ENSG00000050344","","","",22.6,25.4,21,41.2,41,44.2,0.5458860759493671,-0.8733281965115715,3.164455274649781E-4,3.499701038118702,0.01830227169219666,1.7374950019550728,135]
["High","Q9Y4B4","Helicase ARIP4 [OS=Homo sapiens]",11,12,19,12,1467,162.7,6.09,39.73,"cell organization and biogenesis","nucleus","nucleic acid binding activity;other molecular function","RAD54L2","ENSG00000164080","","","",782,804,781.9,869.2,745.7,782,0.9879010388418374,-0.01756156514500242,0.8086848343126116,0.0922207013633612,0.9031914155790117,0.04422019883373375,6991]
["High","Q9Y4B5","Microtubule cross-linking factor 1 [OS=Homo sapiens]",4,6,8,3,1905,209.4,6.43,15.27,"cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MTCL1","ENSG00000168502","","","",63.1,70,66.1,73.5,69.3,67.8,0.9458689458689457,-0.08028778895763627,0.22154243185690853,0.6545430813756449,0.4527095807219947,0.34418031440541835,3821]
["High","Q9Y4B6","DDB1- and CUL4-associated factor 1 [OS=Homo sapiens]",14,17,28,17,1507,168.9,5.06,41.4,"protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","DCAF1","ENSG00000145041","Hippo-Merlin signaling dysregulation","Antigen processing: Ubiquitination & Proteasome degradation","Human immunodeficiency virus 1 infection",811.1,786.9,816.1,900.9,898,923.8,0.8866566276122966,-0.17355258962921824,1.070097885713942E-3,2.9705764940147574,0.03071810401343551,1.5126055933903206,272]
["High","Q9Y4C1","Lysine-specific demethylase 3A [OS=Homo sapiens]",18,18,28,17,1321,147.2,8.07,66.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3A","ENSG00000115548","Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; HDMs demethylate histones","Thermogenesis",653,751.9,713.8,598.2,525.1,631.9,1.2070989061075659,0.27154389109284,0.04697174060548084,1.3281633461112117,0.18692933264403383,0.7283225444965059,1962]
["High","Q9Y4C2-1","TRPM8 channel-associated factor 1 [OS=Homo sapiens]",17,10,38,10,921,102.1,6.54,88.55,"other biological processes","plasma membrane;other membranes","other molecular function","TCAF1","ENSG00000198420","","","",1045.6,1094.5,1066.5,637.2,642.7,658.5,1.6542509286009077,0.7261780894005814,1.0852715215795521E-5,4.964461593086069,0.007703454582266494,2.113314473585659,11]
["Medium","Q9Y4C4","Malignant fibrous histiocytoma-amplified sequence 1 [OS=Homo sapiens]",1,1,1,1,1052,116.9,7.88,0,"stress response;developmental processes;other biological processes","other cell component","other molecular function","MFHAS1","ENSG00000147324","","","",28.2,41.9,23.7,15.7,25.4,19.6,1.5453047775947284,0.6278914062596946,0.14755358157906118,0.8310502443738169,0.36048134072882027,0.4431172103571353,3196]
["High","Q9Y4C5-1","Carbohydrate sulfotransferase 2 [OS=Homo sapiens]",4,2,2,2,530,57.8,9.98,2.4,"other metabolic processes;stress response;developmental processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","CHST2; HEL-S-75","ENSG00000175040; ENSPTRG00000043559","Metapathway biotransformation Phase I and II","Keratan sulfate biosynthesis","Glycosaminoglycan biosynthesis",136.4,126.3,140.5,136.4,128.2,139.9,0.9967861557478368,-0.004644063817423501,0.9405669404338871,0.026610290143902943,0.9729659076454412,0.01190237697816131,7548]
["High","Q9Y4C8","Probable RNA-binding protein 19 [OS=Homo sapiens]",28,23,42,23,960,107.3,6.54,86.59,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","RBM19","ENSG00000122965","","","",2093.2,2319.4,2188.4,2064.6,2186.4,2178.4,1.0266898933026412,0.038000488419962355,0.49600266269497767,0.304515992077077,0.7042714657796664,0.15225990710032078,5499]
["High","Q9Y4D1","Disheveled-associated activator of morphogenesis 1 [OS=Homo sapiens]",9,10,10,10,1078,123.4,7.23,14.3,"cell-cell signaling;cell organization and biogenesis;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","DAAM1","ENSG00000100592","Physico-chemical features and toxicity-associated pathways; Wnt signaling","RHO GTPases Activate Formins; RHOA GTPase cycle; PCP/CE pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle","Wnt signaling pathway",396.5,425.9,406.1,327.9,312.6,333.4,1.261423144059965,0.33505230852482043,1.3487072750922489E-3,2.870082299851626,0.033219894018675956,1.4786017574107422,317]
["High","Q9Y4D8-1","Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",3,8,10,7,3996,439.1,6.19,14.21,"protein metabolism;other metabolic processes;other biological processes","other membranes","other molecular function","HECTD4","","","","",128.8,132.8,139.8,118.8,132,135.7,1.0385510996119016,0.05457220255040726,0.4580099745459251,0.3391250638234573,0.6749984675829716,0.17069721312603417,5298]
["High","Q9Y4E1","WASH complex subunit 2C [OS=Homo sapiens]",28,24,45,6,1318,144.6,4.79,72.31,"","","","","","","","",76.8,99.6,91.7,125.7,105.3,112.2,0.7811771561771562,-0.35627833351698435,0.04936874114246514,1.3065479467495027,0.19283198141088934,0.7148209362089842,1999]
["High","Q9Y4E5","E3 SUMO-protein ligase ZNF451 [OS=Homo sapiens]",14,13,18,13,1061,121.4,6.77,38.79,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","ZNF451","ENSG00000112200","","","",820.7,793.8,796.8,740.6,751.9,750.1,1.0752251850530636,0.10463883594287623,0.003633487699078223,2.4396763057422204,0.05177056925985907,1.285917059567954,548]
["High","Q9Y4E8","ubiquitin carboxyl-terminal hydrolase 15 [OS=Homo sapiens]",31,25,59,23,981,112.3,5.22,110.07,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","USP15","ENSG00000135655","","Ub-specific processing proteases; UCH proteinases; Downregulation of TGF-beta receptor signaling","Mitophagy",2258.1,2333.1,2276.4,2225,2109.2,2134.7,1.061633353429486,0.08628560181116537,0.033453777051695215,1.4755548417196334,0.15474353745239114,0.8103874793506343,1688]
["High","Q9Y4F1","FERM, RhoGEF and pleckstrin domain-containing protein 1 [OS=Homo sapiens]",13,10,15,10,1045,118.6,8.15,31.63,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","FARP1","ENSG00000152767","","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOA GTPase cycle; RHOF GTPase cycle","",658.8,670,687.8,667.1,706.6,707.8,0.9688205620946432,-0.045698609998422755,0.24312767012602993,0.6141656117070476,0.47482262339770925,0.32346859683051044,3998]
["High","Q9Y4F5","Centrosomal protein of 170 kDa protein B [OS=Homo sapiens]",8,11,13,9,1589,171.6,6.84,26.46,"","cytoskeleton;other cell component","","CEP170B","ENSG00000099814","","","",423.8,456,423.4,407.6,340.8,384.2,1.1506268762140206,0.20242007403793577,0.06370112136887197,1.195852922452299,0.2204691292766633,0.6566522131049681,2256]
["High","Q9Y4G6","Talin-2 [OS=Homo sapiens]",34,72,166,53,2542,271.4,5.57,360.2,"cell adhesion;cell organization and biogenesis","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN2","ENSG00000171914","Focal adhesion","","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection",3912.4,3937.8,3942.8,3531,3380.1,3381.7,1.14575237058915,0.19629527068597422,6.0244713559976112E-4,3.220081056179801,0.023171956821492288,1.635037289434378,203]
["High","Q9Y4G8","rap guanine nucleotide exchange factor 2 [OS=Homo sapiens]",4,4,6,3,1499,167.3,6.67,7.87,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RAPGEF2","ENSG00000109756","MAPK signaling pathway","RAF/MAP kinase cascade","MAPK signaling pathway; Rap1 signaling pathway; Tight junction",22.5,28.7,42.3,27,26.6,31.8,1.094847775175644,0.13073029515450862,0.6800147641244021,0.16748165801707146,0.8263899265810634,0.08281498536176816,6425]
["High","Q9Y4H2","Insulin receptor substrate 2 [OS=Homo sapiens]",6,7,8,7,1338,137.2,8.65,17,"other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","IRS2","ENSG00000185950","Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Nonalcoholic fatty liver disease; Insulin signaling; FOXA2 pathway; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways","PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF/MAP kinase cascade; Growth hormone receptor signaling; Interleukin-7 signaling; Signaling by Leptin; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); PI3K Cascade; PI3K/AKT activation; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; SOS-mediated signalling; IRS activation; Signal attenuation","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Alzheimer disease; MicroRNAs in cancer",417.4,428.3,435.2,369.9,342.7,333.3,1.2246868725499573,0.29241292868439994,0.002965940251887423,2.5278376019714788,0.04726134997293265,1.325493877341357,490]
["High","Q9Y4I1-1","Unconventional myosin-Va [OS=Homo sapiens]",10,15,19,11,1855,215.3,8.48,27.22,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5A","ENSG00000197535","Joubert syndrome","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing","Pathogenic Escherichia coli infection",780,764.6,798.2,763.3,789.8,742.2,1.0206944625974819,0.029551070658852582,0.40059115017149416,0.3972986493363516,0.6283277823501459,0.20181373695029067,4978]
["High","Q9Y4I5","Tesmin [OS=Homo sapiens]",10,3,3,3,508,55,5.71,5.92,"other biological processes","nucleus;other cell component","other molecular function","TESMIN","ENSG00000132749","","","",58.2,55.3,43.8,72,52.6,59.8,0.8530368763557485,-0.22931998501365103,0.2761421169095819,0.5588673501644951,0.5116558255410574,0.291022076777941,4214]
["High","Q9Y4K0","Lysyl oxidase homolog 2 [OS=Homo sapiens]",8,5,7,5,774,86.7,6.38,16.64,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","LOXL2","ENSG00000134013","Canonical and non-canonical TGF-B signaling","Crosslinking of collagen fibrils; Elastic fibre formation","",247.5,237.4,271.2,255.5,238.1,227.5,1.0485369574261543,0.06837771251297939,0.41763340132929305,0.37920477477373854,0.6417794917494825,0.19261416502539877,5081]
["High","Q9Y4K3","TNF receptor-associated factor 6 [OS=Homo sapiens]",19,6,9,6,522,59.5,6.44,15.13,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TRAF6","ENSG00000175104","IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; T-cell receptor (TCR) signaling pathway; Toll-like receptor signaling pathway","Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; TRAF6 mediated NF-kB activation; Ovarian tumor domain proteases; TRAF6 mediated IRF7 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PIP3 activates AKT signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","MAPK signaling pathway; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; Autophagy; Endocytosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; Neurotrophin signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis",115.5,127.2,120.1,109.7,98,103.3,1.1665594855305466,0.22225987551055748,0.022786304973654258,1.6423260942867965,0.1274466111993499,0.8946717079153034,1396]
["High","Q9Y4K4","mitogen-activated protein kinase kinase kinase kinase 5 [OS=Homo sapiens]",12,7,15,7,846,95,7.64,13.31,"","","","","","","","",399.4,392.1,392.8,404.2,376.7,426.2,0.9811117554469391,-0.027510616091992828,0.6280308040324991,0.20201905420350014,0.7956619370251101,0.09927141727554005,6163]
["High","Q9Y4L1","Hypoxia up-regulated protein 1 [OS=Homo sapiens]",61,48,364,48,999,111.3,5.22,807.97,"stress response;transport;other biological processes","non-structural extracellular;ER/Golgi;other cell component","other molecular function","HYOU1","ENSG00000149428; ENSG00000280682","VEGFA-VEGFR2 signaling pathway","XBP1(S) activates chaperone genes; Scavenging by Class F Receptors","Protein processing in endoplasmic reticulum",13064.9,13938.5,13963.4,13883.8,12869.7,13655.9,1.0137938202497438,0.01976427487725203,0.685367768842972,0.1640763232250588,0.8296669052908411,0.0810962332016912,6450]
["High","Q9Y4L5","E3 ubiquitin-protein ligase RNF115 [OS=Homo sapiens]",11,2,2,2,304,33.7,5.69,6.65,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","RNF115","ENSG00000265491","","Antigen processing: Ubiquitination & Proteasome degradation","",61.9,64.9,56.5,66.8,61.9,69.2,0.9262253663466399,-0.11056482650762611,0.21023358333801026,0.6772979072735739,0.4387874415138156,0.35774581081314355,3741]
["High","Q9Y4P1-1","Cysteine protease ATG4B [OS=Homo sapiens]",27,7,28,7,393,44.3,5.07,63.67,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol","other molecular function","ATG4B","ENSG00000168397","","Macroautophagy","Autophagy; Autophagy",518.3,502.4,523.8,531.7,520.4,508.7,0.9895566376217325,-0.015145812094026209,0.5878561606116013,0.2307289261255611,0.766018174575331,0.11576092615833572,5992]
["High","Q9Y4P3","Transducin beta-like protein 2 [OS=Homo sapiens]",25,12,21,12,447,49.8,9.44,35.73,"stress response;signal transduction","other membranes;ER/Golgi","other molecular function","TBL2","ENSG00000106638","7q11.23 copy number variation syndrome","","",849.4,936.1,927,924.1,965.3,907.2,0.9699277694343129,-0.04405078115353427,0.4366629860053645,0.35985361974549396,0.6570561947831733,0.18239748578178575,5189]
["High","Q9Y4P8-1","WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",23,6,9,1,454,49.4,6.46,22.96,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","WIPI2","ENSG00000157954","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease","Macroautophagy","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis",341.8,363.4,353.6,308.3,393.9,358.8,0.9979264844486335,-0.002994556306728373,0.978532918293888,0.009424559895688129,0.9899436416220105,0.004389529472430581,7718]
["High","Q9Y4P8-6","Isoform 6 of WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",24,6,9,1,443,48.2,6.3,21.67,"","","","WIPI2","","","","",31.9,23.9,21,23.6,25,23.5,1.0651872399445215,0.09110705148033366,0.6592652355186508,0.18093982493957486,0.8131979397993089,0.08980373029829457,6330]
["High","Q9Y4R8","telomere length regulation protein TEL2 homolog [OS=Homo sapiens]",23,15,27,15,837,91.7,5.76,55.26,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TELO2","ENSG00000100726","Fragile X syndrome; Malignant pleural mesothelioma","","Fanconi anemia pathway; mTOR signaling pathway",742.7,657.5,673.1,716.4,715.8,763.1,0.9444267298319138,-0.08248922056961867,0.2535333958544766,0.5959648265473955,0.487943986894689,0.3116300295930863,4057]
["Low","Q9Y4U1","Methylmalonic aciduria and homocystinuria type C protein [OS=Homo sapiens]",3,1,1,1,282,31.7,7.81,0,"other metabolic processes","cytosol;other cell component","other molecular function","MMACHC","ENSG00000132763","","Cobalamin (Cbl, vitamin B12) transport and metabolism; Defective MMADHC causes MMAHCD; Defective MMACHC causes MAHCC","Vitamin digestion and absorption",28.4,24.7,26.2,25.4,32.7,26.6,0.9362455726092089,-0.09504110362822024,0.511740461281037,0.2909502437345695,0.714916715276854,0.1457445486918392,5589]
["High","Q9Y4W2","Ribosomal biogenesis protein LAS1L [OS=Homo sapiens]",44,25,55,25,734,83,4.73,103.69,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LAS1L","ENSG00000001497","","Major pathway of rRNA processing in the nucleolus and cytosol","",2348.6,2315.9,2331.4,2581.5,2608.2,2526.7,0.906627442848997,-0.14141826383890352,7.3897417630801917E-4,3.131370737901365,0.025990587246004563,1.585183907693368,222]
["High","Q9Y4W6","AFG3-like protein 2 [OS=Homo sapiens]",29,22,59,21,797,88.5,8.66,131.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","AFG3L2","ENSG00000141385","Ciliary landscape","Processing of SMDT1","Spinocerebellar ataxia",3138.3,3037.3,3097.1,2966.1,3029.5,3013.7,1.0292364556624822,0.04157446349800663,0.06599524087466169,1.1804873816762418,0.2248214837475386,0.6481621903129587,2292]
["High","Q9Y4X0","AMME syndrome candidate gene 1 protein [OS=Homo sapiens]",10,3,4,2,333,35.4,8.63,6.99,"","mitochondrion;nucleus","","AMMECR1","ENSG00000101935","","","",153.9,138.4,137.7,132,161.2,138.8,0.9953703703703705,-0.006694652574008126,0.9514249371119613,0.021625469787896732,0.9772067757129957,0.010013530396346313,7602]
["High","Q9Y4X5","E3 ubiquitin-protein ligase ARIH1 [OS=Homo sapiens]",37,15,42,15,557,64.1,5.08,85.92,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ARIH1","ENSG00000166233","","ISG15 antiviral mechanism","",1462.4,1504.1,1534.4,1428.7,1398.7,1422.7,1.0590103762264416,0.08271672498378402,0.021438663884750606,1.6688022845371753,0.122273986568395,0.9126659280125298,1369]
["High","Q9Y4Y9","U6 snRNA-associated Sm-like protein LSm5 [OS=Homo sapiens]",32,2,2,2,91,9.9,4.54,0,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM5","ENSG00000106355","","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",136.7,116.6,108.1,124.7,116.7,117.9,1.0058446980239353,0.008407570862435225,0.9406731507563628,0.026561251685454836,0.9729468752292596,0.011910872398303437,7549]
["Low","Q9Y4Z0","U6 snRNA-associated Sm-like protein LSm4 [OS=Homo sapiens]",5,1,1,1,139,15.3,9.99,2.19,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM4","ENSG00000130520","Ciliary landscape","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","RNA degradation; Spliceosome",123.8,112.2,110.7,149.4,113.4,115.5,0.916468411313772,-0.12584293984654288,0.44274147271413217,0.35384979465253796,0.6619926118253435,0.1791468574808282,5222]
["High","Q9Y508-1","E3 ubiquitin-protein ligase RNF114 [OS=Homo sapiens]",27,5,13,5,228,25.7,7.25,31.58,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","RNF114","ENSG00000124226; ENSPPAG00000043607; ENSPTRG00000013613","","Antigen processing: Ubiquitination & Proteasome degradation","",518.1,455.9,470.2,498.8,443.6,454.7,1.0337126905733305,0.04783525965416888,0.567877668575121,0.24574520933254265,0.7542080007202832,0.12250886486298901,5879]
["High","Q9Y512","sorting and assembly machinery component 50 homolog [OS=Homo sapiens]",33,13,45,13,469,51.9,6.9,78.11,"cell organization and biogenesis;transport","other membranes;mitochondrion","","SAMM50","ENSG00000100347","","RAC2 GTPase cycle; Mitochondrial protein import; Cristae formation","",1248.4,1241.4,1267.1,1199.6,1360,1327.4,0.9665294571649086,-0.04911439239589119,0.43081560779022693,0.3657085712645304,0.651269751331286,0.18623909246153433,5165]
["High","Q9Y520","Protein Prrc2c [OS=Homo sapiens]",27,63,184,62,2896,316.7,9.13,350.47,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;other cell component","other molecular function","PRRC2C","ENSG00000117523","VEGFA-VEGFR2 signaling pathway","","",7930.6,9526.8,9347.9,10781.8,8622.3,9147.1,0.9388502059458098,-0.09103310141536582,0.5186323874554897,0.28514036598161707,0.7200358608201393,0.14264587333474923,5624]
["High","Q9Y530","O-acetyl-ADP-ribose deacetylase 1 [OS=Homo sapiens]",14,2,3,2,152,17,8.31,5.34,"protein metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","OARD1","ENSG00000124596","","","",137.3,112,105.2,140.1,130.6,140.8,0.8614823815309843,-0.21510680318210934,0.13899382571630078,0.8570044912343674,0.34728441318172054,0.4593147082558259,3125]
["High","Q9Y535","DNA-directed RNA polymerase III subunit RPC8 [OS=Homo sapiens]",27,3,4,3,204,22.9,4.58,7.21,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR3H","ENSG00000100413","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","RNA polymerase; Cytosolic DNA-sensing pathway",95.4,104.4,91.3,114.3,113.2,109.1,0.8648247177658943,-0.20952033720718316,0.022188901456497323,1.653864198587786,0.12518131688752246,0.9024604840498895,1384]
["High","Q9Y546","Leucine-rich repeat-containing protein 42 [OS=Homo sapiens]",7,3,3,3,428,48.5,7.46,8.42,"","","","LRRC42","ENSG00000116212","","","",193.8,189.3,203.7,273.3,275.9,285.6,{"$f":"AVERAGE(T7682:V7682)/AVERAGE(W7682:Y7682)","v":0.702922855773838},{"$f":"LOG(Z7682,2)","v":-0.5085617294864453},{"$f":"TTEST(T7682:V7682,W7682:Y7682,2,2)","v":1.2832208646127423E-4},{"$f":"-LOG10(AB7682)","v":3.891698587563252},{"$f":"AB7682*7808/AF7682","v":0.01391581737624485},{"$f":"-LOG10(AD7682)","v":1.8564912793358852},72]
["High","Q9Y547","Intraflagellar transport protein 25 homolog [OS=Homo sapiens]",42,4,11,4,144,16.3,5.03,29.53,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","HSPB11","ENSG00000081870","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis","Intraflagellar transport","",214.1,234.5,234.7,219.1,238.6,225.9,0.9995611468695142,-6.3327020150137409E-4,0.9915808099178638,3.671886732195157E-3,0.9963020156786361,1.6089910337304958E-3,7771]
["High","Q9Y548","Protein YIPF1 [OS=Homo sapiens]",6,2,4,2,306,34.3,5.31,12.28,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","YIPF1","ENSG00000058799","","","",273.9,291.1,292.3,247.6,253.3,268,1.1149694368578487,0.1570041640487684,0.025663877866013728,1.5906777201915394,0.13512040349146,0.869279066561286,1483]
["High","Q9Y570","Protein phosphatase methylesterase 1 [OS=Homo sapiens]",41,14,44,14,386,42.3,5.97,87.1,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","nucleus","enzyme regulator activity;other molecular function","PPME1","ENSG00000214517","","Cyclin A/B1/B2 associated events during G2/M transition","",1727,1752.6,1704.8,1649.5,1713.7,1695.1,1.0249293240812132,0.035524429425340454,0.14879581448208343,0.8274092850058712,0.36215639634542,0.4411038399593617,3208]
["High","Q9Y573-1","actin-binding protein IPP [OS=Homo sapiens]",3,2,2,2,584,65.2,5.73,2.39,"","cytoskeleton;other cell component","cytoskeletal activity","IPP","ENSG00000197429; ENSPPAG00000037424","","","",119.3,121.8,131.1,116,122.5,120.1,1.0379252649191297,0.053702567190776374,0.32678364896068113,0.48573968207782464,0.5641226467134641,0.2486264651651079,4523]
["High","Q9Y575","Ankyrin repeat and SOCS box protein 3 [OS=Homo sapiens]",2,1,3,1,518,57.7,6.27,5.21,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","","ASB3","ENSG00000115239","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",22.9,32.9,28.3,27.5,27.2,38.4,0.9033297529538131,-0.14667536730364944,0.5565877133368803,0.25446638493853685,0.7452987250444798,0.1276696217009458,5831]
["High","Q9Y576","Ankyrin repeat and SOCS box protein 1 [OS=Homo sapiens]",3,1,1,1,335,37,8.21,2.49,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","","ASB1","ENSG00000065802","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",52.1,60.7,53.3,47.8,74.7,63.4,0.8934911242603552,-0.16247469695710523,0.46847559392944577,0.32931302953150654,0.6830732842952592,0.16553270004074552,5355]
["High","Q9Y580","RNA-binding protein 7 [OS=Homo sapiens]",6,2,4,2,266,30.5,9.57,11.13,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RBM7","ENSG00000076053","","","",421,414,384.8,558.4,461.2,491.5,0.8072265237244391,-0.30895451581345384,0.0343610804978005,1.4639331880638906,0.1560740642971648,0.8066692600923077,1719]
["High","Q9Y587-1","AP-4 complex subunit sigma-1 [OS=Homo sapiens]",7,1,3,1,144,17,5.19,5.1,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","AP4S1","ENSCANG00000008358; ENSCATG00000035780; ENSG00000100478; ENSGGOG00000003198; ENSMMUG00000003123; ENSPANG00000017427; ENSPCOG00000016646; ENSPPAG00000041450; ENSPTRG00000006239; ENSRROG00000019504","","Lysosome Vesicle Biogenesis","Lysosome",66,75.5,63.9,67.1,83.9,66.4,0.9448022079116836,-0.08191575870911404,0.5849080589026241,0.2329123948568375,0.7646010587496549,0.11656510494527413,5973]
["High","Q9Y592","Centrosomal protein of 83 kDa [OS=Homo sapiens]",2,2,4,2,693,82,6.28,6.88,"","","","","","","","",53.4,53.2,51.3,52.9,53.6,45.4,1.0394996708360762,0.05588930135815329,0.5012303245256824,0.29996266198799276,0.7077045884080521,0.15014798863405565,5530]
["High","Q9Y597","BTB/POZ domain-containing protein KCTD3 [OS=Homo sapiens]",9,6,8,6,815,88.9,7.03,12.51,"cell organization and biogenesis","plasma membrane;other membranes","","KCTD3","ENSG00000136636","","CDC42 GTPase cycle","",268,271.2,259.5,301.3,265.5,252.1,0.9753327634631824,-0.0360335741863977,0.6786236153535097,0.1683710314588552,0.8253416181744866,0.08336625486907305,6420]
["High","Q9Y5A7","NEDD8 ultimate buster 1 [OS=Homo sapiens]",24,16,25,16,615,70.5,5.96,60.75,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","","NUB1","ENSG00000013374","","","",1416.6,1539.2,1544.1,1196,1184,1180.8,1.263732869018198,0.33769153529346846,1.7256144929671535E-3,2.7630562203688696,0.037219883870407554,1.4292249862433997,362]
["High","Q9Y5A9-1","YTH domain-containing family protein 2 [OS=Homo sapiens]",18,10,41,7,579,62.3,8.79,79.38,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity","YTHDF2","ENSCSAG00000001018; ENSG00000198492; ENSMFAG00000026128; ENSMMUG00000011391; ENSMNEG00000041161; ENSNLEG00000009856; ENSPTRG00000000439; ENSRBIG00000043898; ENSRROG00000038863","","","",1807.9,1720.9,1764.6,2101.9,2112.3,2144.3,0.8324919399229376,-0.26449179061877603,2.2813309954313672E-4,3.6418116989142075,0.01649317815956307,1.7826956497425217,108]
["High","Q9Y5B0","RNA polymerase II subunit A C-terminal domain phosphatase [OS=Homo sapiens]",25,19,43,19,961,104.3,5.27,78.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CTDP1","ENSG00000060069","","TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1741.7,1788.7,1765.2,1681.5,1655.2,1709.4,1.0494441251659696,0.06962535625191699,0.015923445580129918,1.7979629520174756,0.10421648205335658,0.9820635910291821,1193]
["High","Q9Y5B6","PAX3- and PAX7-binding protein 1 [OS=Homo sapiens]",15,12,23,12,917,104.7,5.68,46.07,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity","PAXBP1","ENSG00000159086; ENSG00000263141","","","",1015.5,1104.2,1112.2,1193.4,1133.5,1173.7,0.9232417299891446,-0.11521966045358806,0.06588194359035908,1.1812335971447074,0.22472967040346165,0.6483395851606149,2289]
["High","Q9Y5B8","Nucleoside diphosphate kinase 7 [OS=Homo sapiens]",15,4,8,4,376,42.5,6.47,11.18,"other metabolic processes","cytosol;cytoskeleton","kinase activity;other molecular function","NME7","ENSG00000143156","Pyrimidine metabolism; Ciliopathies","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors",188.9,198.7,215.7,210.4,220.5,224.9,0.9199451052150046,-0.1203803193665527,0.12154997748436078,0.9152451172683523,0.31826365667266565,0.4972129517266927,2982]
["High","Q9Y5B9","FACT complex subunit SPT16 [OS=Homo sapiens]",44,50,246,50,1047,119.8,5.66,516.81,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","SUPT16H","ENSG00000092201","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation","",11776.2,12101.9,12043.3,11567.9,12787.2,12232.8,0.9817835951229777,-0.02652303434805405,0.5770492925407636,0.23878708707980612,0.7594135978692538,0.11952163075862453,5933]
["Medium","Q9Y5E1","Protocadherin beta-9 [OS=Homo sapiens]",1,1,1,1,797,87,5.02,2.2,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;other cell component","other molecular function","PCDHB9","ENSG00000177839","","","",83.6,82.1,95.8,79.9,97.1,85.3,0.9969500571864278,-4.406861130680402E-3,0.970066404665324,0.013198535638264846,0.9858490807792334,6.1895641677215665E-3,7683]
["Low","Q9Y5F9-1","Protocadherin gamma-B6 [OS=Homo sapiens]",1,1,1,1,930,101,5.26,0,"cell adhesion","plasma membrane;other membranes","other molecular function","PCDHGB6","ENSG00000253305","","","",104.6,108.8,94.7,91.1,89.9,101.3,1.0913921360255046,0.12616955358965803,0.1947049356936204,0.7106230391459444,0.4176527851362056,0.3791846181363649,3640]
["High","Q9Y5J1","U3 small nucleolar RNA-associated protein 18 homolog [OS=Homo sapiens]",25,11,31,11,556,62,8.76,68.25,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","UTP18","ENSG00000011260","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Ribosome biogenesis in eukaryotes",1328.2,1404,1372.9,1768.2,1663.6,1761.5,0.7904607860127472,-0.3392342012198529,8.4618552554233258E-4,3.0725344077814407,0.027877707103099295,1.554742949132909,237]
["High","Q9Y5K3","Choline-phosphate cytidylyltransferase B [OS=Homo sapiens]",26,8,15,5,369,41.9,6.4,29.65,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","PCYT1B","ENSG00000102230","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways","Synthesis of PC","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer",210.6,222.2,218.5,263.8,235.4,233.1,0.8893895944285128,-0.1691125691660096,0.06105903367245733,1.2142500731791905,0.21670406132479403,0.6641329493427613,2200]
["High","Q9Y5K5-1","Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",58,14,68,1,329,37.6,5.33,154.39,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UCHL5","ENSCANG00000036448; ENSCATG00000035323; ENSG00000116750; ENSGGOG00000004347; ENSMFAG00000038349; ENSMLEG00000030039; ENSMNEG00000039813; ENSPPAG00000029294; ENSPTRG00000001793","TGF-beta signaling pathway","UCH proteinases; Downregulation of TGF-beta receptor signaling","",28.7,34.7,31.3,27.8,24.5,24.5,1.2330729166666667,0.3022581147472289,0.04403598176358808,1.3561923168010448,0.1805845302574032,0.7433194561908648,1904]
["High","Q9Y5K5-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",58,14,68,1,328,37.5,5.4,158.34,"","","","UCHL5","","","","",2676,2850.5,2878,2561.5,2820.3,2630,1.0490152025762,0.06903558594412718,0.26055079995581376,0.5841075891030065,0.49558602827161846,0.3048809458998307,4105]
["High","Q9Y5K6","CD2-associated protein [OS=Homo sapiens]",40,21,42,21,639,71.4,6.4,76.66,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CD2AP","ENSG00000198087","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis","Nephrin family interactions","Bacterial invasion of epithelial cells",1997.5,2165.3,2116.2,2280.5,2116.2,2175.8,0.9553442373526055,-0.06590742452854287,0.23025287468862324,0.6377949389655857,0.46156981914474204,0.33576259631553357,3895]
["High","Q9Y5K8","V-type proton ATPase subunit D [OS=Homo sapiens]",47,12,31,12,247,28.2,9.36,54.53,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol","transporter activity","ATP6V1D","ENSG00000100554","Proximal tubule transport","Amino acids regulate mTORC1; Neutrophil degranulation; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis",778.4,860.2,848.3,727.5,756.9,763.2,1.1064691226196828,0.14596319152300236,0.045435610317960944,1.3426036338722216,0.18362383300343635,0.7360709512930609,1932]
["High","Q9Y5L0-2","transportin-3 [OS=Homo sapiens]",34,23,66,23,923,104.1,5.57,160,"transport","other membranes;nucleus;other cell component","other molecular function","TNPO3","ENSCANG00000033070; ENSCATG00000030018; ENSG00000064419; ENSGGOG00000008339; ENSMLEG00000037881; ENSMMUG00000004311; ENSMNEG00000045277; ENSPPAG00000034975; ENSPPYG00000017990; ENSPTRG00000019676","","","Nucleocytoplasmic transport",2607.1,2618.9,2575.7,2543.6,2540.7,2587.5,1.0169321410881411,0.02422341274317743,0.09500521930768321,1.0222525351926084,0.27658491884951175,0.5581715040495532,2682]
["High","Q9Y5M8","signal recognition particle receptor subunit beta [OS=Homo sapiens]",30,7,22,7,271,29.7,9.04,48.58,"transport","other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SRPRB","ENSG00000144867","","SRP-dependent cotranslational protein targeting to membrane; XBP1(S) activates chaperone genes","Protein export",962.8,984.4,986.3,908.9,1032.3,994.4,0.9992846436844257,-1.0324103236126908E-3,0.9859128605087228,0.006161468296709755,0.9943176976042505,0.00247483062101068,7742]
["Low","Q9Y5N1","histamine H3 receptor [OS=Homo sapiens]",2,1,1,1,445,48.6,9.29,2.08,"cell-cell signaling;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","HRH3","ENSG00000101180","GPCRs, class A rhodopsin-like; Monoamine transport","Histamine receptors","Neuroactive ligand-receptor interaction",111.1,102.4,113.4,90.6,84.3,108.4,1.153900458877515,0.20651877538916752,0.1417617489608765,0.8484409373914755,0.35116615986247585,0.4544873415503578,3152]
["High","Q9Y5N5","HemK methyltransferase family member 2 [OS=Homo sapiens]",24,5,9,5,214,22.9,5.11,15.88,"protein metabolism;DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","N6AMT1","ENSG00000156239","","Eukaryotic Translation Termination; Methylation","",429.7,443.1,436.4,427.1,470.6,431,0.9853240009031381,-0.02132989556170956,0.6755987521657315,0.17031116124436466,0.8241017117497316,0.08401918378151965,6401]
["High","Q9Y5N6","Origin recognition complex subunit 6 [OS=Homo sapiens]",41,8,12,8,252,28.1,8.66,17.75,"DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC6","ENSG00000091651","Cell cycle; G1 to S cell cycle control; DNA replication","Assembly of the ORC complex at the origin of replication; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDT1 association with the CDC6:ORC:origin complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle",564.2,549.3,539.6,528.6,532.4,510.3,1.0520588048113027,0.07321534630189752,0.0509404292791373,1.29293739952209,0.19670765173664886,0.7061787461184369,2022]
["High","Q9Y5P4-1","Collagen type IV alpha-3-binding protein [OS=Homo sapiens]",24,14,39,14,624,70.8,5.48,67.26,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus","transporter activity;kinase activity;other molecular function","CERT1","ENSG00000113163; ENSPTRG00000016996","Sphingolipid pathway","","",1403.9,1358.3,1377.9,1320.5,1208.4,1291.2,1.0837674406429152,0.11605521035745428,0.04167339216272314,1.3801411470686995,0.1747507228821387,0.7575810190553879,1862]
["High","Q9Y5P6","Mannose-1-phosphate guanyltransferase beta [OS=Homo sapiens]",20,5,17,5,360,39.8,6.61,37.01,"other metabolic processes","other cell component","other molecular function","GMPPB","ENSG00000173540","","Synthesis of GDP-mannose","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars",360,372.4,353.7,353.3,330.4,344.5,1.0563120015561174,0.07903602467275439,0.08924284841851363,1.0494265765246797,0.26883030881626324,0.5705217690646002,2592]
["High","Q9Y5Q0","fatty acid desaturase 3 [OS=Homo sapiens]",16,5,7,4,445,51.1,7.77,15.7,"other metabolic processes","other membranes;ER/Golgi","other molecular function","FADS3","ENSG00000221968","","","",117.3,113.7,124.3,146.8,142.1,137.4,0.8334506216279616,-0.2628313666327143,0.004587552677078023,2.3384189358770833,0.05777356661713743,1.2382708207167017,620]
["High","Q9Y5Q8-1","general transcription factor 3C polypeptide 5 [OS=Homo sapiens]",30,13,22,13,519,59.5,6.9,44.41,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity","GTF3C5","ENSG00000148308","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",964.6,990.3,1010.4,1020.8,1073.9,1013,0.9541783312417546,-0.06766917084246914,0.11102578540891318,0.9545761458953309,0.30048157104776224,0.5221821587284458,2885]
["High","Q9Y5Q9","General transcription factor 3C polypeptide 3 [OS=Homo sapiens]",24,14,47,14,886,101.2,5.07,80.98,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","nucleic acid binding activity","GTF3C3","ENSG00000119041","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1517.8,1412.6,1383.9,1504,1574.9,1528.6,0.9363646228974496,-0.09485766634788853,0.0992542822929009,1.003250746670072,0.283148496946646,0.5479857394215601,2737]
["Medium","Q9Y5R2","Matrix metalloproteinase-24 [OS=Homo sapiens]",2,1,1,1,645,73.2,9.23,0,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","MMP24","ENSG00000125966","Matrix metalloproteinases","Activation of Matrix Metalloproteinases","Parathyroid hormone synthesis, secretion and action",25.1,39.3,37.8,29,51.9,42,0.8315703824247356,-0.2660897194350403,0.43789562272981036,0.35862939605882355,0.6580232914307851,0.1817587338011784,5196]
["High","Q9Y5S2","Serine/threonine-protein kinase MRCK beta [OS=Homo sapiens]",16,25,42,23,1711,194.2,6.37,97.64,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPB","ENSG00000198752","VEGFA-VEGFR2 signaling pathway","CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle","",1773.4,1942,1895.7,1840.5,1934.7,1872.1,0.9935898570998531,-0.009277648771028877,0.8437852512237713,0.07376807005168556,0.9233742454877655,0.034622242843715914,7135]
["High","Q9Y5S9","RNA-binding protein 8A [OS=Homo sapiens]",48,8,62,2,174,19.9,5.72,123.74,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","RBM8A","ENSG00000265241","","mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome",1858.3,1810.2,1794.1,2680.6,1785.4,1554.8,0.9072880680308265,-0.14036740925374308,0.6171870368091128,0.20958320428969526,0.7870319097510293,0.10400765906679284,6123]
["High","Q9Y5S9-2","Isoform 2 of RNA-binding protein 8A [OS=Homo sapiens]",47,7,53,1,173,19.7,5.92,108.93,"","","","RBM8A","","","","",145.7,144,141.2,202.2,142.5,124.9,0.9175894378194207,-0.12407930999966968,0.6112047792480664,0.21381325850149624,0.7823421174375249,0.10660328885362792,6100]
["High","Q9Y5T5-1","ubiquitin carboxyl-terminal hydrolase 16 [OS=Homo sapiens]",12,6,11,6,823,93.5,6.93,26.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","USP16","ENSG00000156256","","Ub-specific processing proteases","",184.1,184.8,201.6,199.1,200.8,192.6,0.9628691983122363,-0.05458826749693981,0.3052329751227772,0.515368550205128,0.5417729187903261,0.26618270752335543,4399]
["High","Q9Y5U2-1","Protein TSSC4 [OS=Homo sapiens]",7,3,5,3,329,34.3,5.19,2.98,"","","","TSSC4","ENSG00000184281","","","",62.2,57.9,61.5,59.9,57.3,52.9,1.0676072898295121,0.09438106162753009,0.19109468941929816,0.7187513819556695,0.4136588120282451,0.3833577196153971,3607]
["High","Q9Y5U9","immediate early response 3-interacting protein 1 [OS=Homo sapiens]",24,1,4,1,82,9,8.22,14.62,"transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","","IER3IP1","ENSG00000134049","","","",195.8,197.3,209.4,186.7,197.1,190.4,1.0492859630790667,0.06940791079750487,0.14808763985847775,0.8294811883746062,0.3615598161397731,0.44181984312618666,3198]
["High","Q9Y5V3","Melanoma-associated antigen D1 [OS=Homo sapiens]",15,10,29,7,778,86.1,5.83,61.46,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","MAGED1","ENSG00000179222","","NRAGE signals death through JNK; Caspase activation via Dependence Receptors in the absence of ligand","Neurotrophin signaling pathway",720.9,770.2,767.2,725.7,748.1,750.2,1.0154226618705038,0.022080363135029743,0.5551802987804413,0.2555659537253043,0.744052140899019,0.12839662935831742,5826]
["High","Q9Y5W7","Sorting nexin-14 [OS=Homo sapiens]",3,4,4,4,946,110.1,6.7,1.82,"cell organization and biogenesis;other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX14","ENSG00000135317","","","",110.3,120.2,126.8,128.2,137.6,114.3,0.9400157853196529,-0.08924311127669522,0.4113518788287668,0.38578651473531833,0.6373954097826972,0.1955910684324516,5039]
["High","Q9Y5W8","Sorting nexin-13 [OS=Homo sapiens]",3,3,3,3,968,112.1,6.58,7.79,"transport;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","SNX13","ENSG00000071189","","","",60.2,43.9,47.1,49.9,48.3,51.4,1.0106951871657754,0.015347964333436048,0.9212241629336512,0.03563467938005144,0.9629073981507293,0.01641547653681482,7470]
["High","Q9Y5X1","Sorting nexin-9 [OS=Homo sapiens]",29,10,25,10,595,66.6,5.58,34.17,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","SNX9","ENSG00000130340","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","Salmonella infection",520.1,560.5,548.2,604.6,594.2,658.8,0.8768303186907836,-0.18963041078987145,0.03079197876423444,1.5115624014256435,0.14896144373676737,0.8269261271530596,1614]
["High","Q9Y5X2","Sorting nexin-8 [OS=Homo sapiens]",13,6,12,6,465,52.5,7.39,32.15,"transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX8","ENSG00000106266","","","",348.9,343,355.3,383,411.7,396.1,0.8794088008061806,-0.18539412429279561,0.006068720170876293,2.216902887397669,0.06517822158762324,1.1858974935980713,727]
["High","Q9Y5X3","sorting nexin-5 [OS=Homo sapiens]",38,14,50,13,404,46.8,6.76,106.93,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","SNX5","ENSG00000089006","","Golgi Associated Vesicle Biogenesis","Endocytosis",1858.3,2006.4,2000.2,1809.2,1862.5,1835.6,1.0649319993463222,0.0907613108849475,0.07864062702358665,1.1043530324114486,0.25041844037527106,0.6013336935991906,2452]
["High","Q9Y5Y0","Feline leukemia virus subgroup C receptor-related protein 1 [OS=Homo sapiens]",17,6,22,6,555,59.8,5.97,57.32,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion","transporter activity;other molecular function","FLVCR1","ENSG00000162769","","","",726.2,662.4,661.2,687.3,662.2,697.7,1.0012700273544355,1.8310996386919757E-3,0.9728286439671869,0.011963650516090645,0.986729806715484,0.005801752616027347,7698]
["High","Q9Y5Y2","Cytosolic Fe-S cluster assembly factor NUBP2 [OS=Homo sapiens]",24,5,9,5,271,28.8,5.83,21.95,"cell organization and biogenesis;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NUBP2","ENSG00000095906","","Cytosolic iron-sulfur cluster assembly","",388,396.4,361,325.1,319.8,366.9,1.1320419055149238,0.1789273643178229,0.07199637058086665,1.1426893962969455,0.2377951190758912,0.6237970638475279,2364]
["High","Q9Y5Z4-1","Heme-binding protein 2 [OS=Homo sapiens]",10,2,2,2,205,22.9,4.63,3.08,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","HEBP2","ENSG00000051620","","Neutrophil degranulation","",107,100.2,120,107.3,117.3,112.7,0.9700563296768455,-0.043859570076377766,0.6311917599926167,0.19983867933776156,0.7975959317077764,0.09821706989370449,6179]
["Medium","Q9Y5Z6","Beta-1,3-galactosyltransferase 1 [OS=Homo sapiens]",3,1,1,1,326,38,9.29,2.12,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B3GALT1","ENSG00000172318","Ganglio sphingolipid metabolism; Metabolism of spingolipids in ER and Golgi apparatus","Lewis blood group biosynthesis","Glycosphingolipid biosynthesis; Metabolic pathways",26,31.5,21.9,18.2,27.2,22,1.1780415430267062,0.23639041596109922,0.35335726502005155,0.45178597516945374,0.5896588000163631,0.2293992157029985,4679]
["High","Q9Y5Z9-1","UbiA prenyltransferase domain-containing protein 1 [OS=Homo sapiens]",6,1,1,1,338,36.8,8.15,3.75,"other metabolic processes;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","UBIAD1","ENSG00000120942; ENSGGOG00000001270","7q11.23 copy number variation syndrome","Metabolism of vitamin K","",36.4,26,31.4,27.2,29.2,24.8,1.1551724137931034,0.2081081953302003,0.2672500083340725,0.5730822725759042,0.5033015111125031,0.29817176567511083,4146]
["High","Q9Y605","MORF4 family-associated protein 1 [OS=Homo sapiens]",19,1,2,1,127,14.6,4.7,9.33,"","nucleus;other cell component","","MRFAP1","ENSG00000179010","","","",53.9,33.6,37,35.1,28.3,30.3,1.3287086446104588,0.41002478929625635,0.19444197953686868,0.7112099661946841,0.41731802535015683,0.3795328562635135,3638]
["High","Q9Y606","tRNA pseudouridine synthase A [OS=Homo sapiens]",52,20,47,20,427,47.4,8.41,88.3,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","PUS1","ENSG00000177192","","","",1758.1,1749.7,1674.4,1641,1708,1671.4,1.0322285076886306,0.045762380079768274,0.17662844855912016,0.7529393457346061,0.39538845365527814,0.4029760173365003,3488]
["High","Q9Y608","Leucine-rich repeat flightless-interacting protein 2 [OS=Homo sapiens]",4,3,9,1,721,82.1,6.95,14.51,"cell-cell signaling;signal transduction;other biological processes","","other molecular function","LRRFIP2","ENSG00000093167","VEGFA-VEGFR2 signaling pathway","","",59.5,52.4,48.1,61.3,55.7,46.2,0.9803921568627452,-0.028569152196770795,0.8561906029722032,0.06742954302788798,0.9293947209796972,0.03179979867003883,7193]
["High","Q9Y613","FH1/FH2 domain-containing protein 1 [OS=Homo sapiens]",28,19,40,19,1164,126.5,6.39,72.26,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FHOD1","ENSG00000135723","VEGFA-VEGFR2 signaling pathway","","Salmonella infection",583.9,559.3,537.7,597.5,559.5,549.2,0.9851717266440041,-0.02155287023338614,0.6927351452649875,0.15943277828281538,0.8352186556870016,0.0781998137055161,6476]
["High","Q9Y617-1","phosphoserine aminotransferase [OS=Homo sapiens]",68,22,169,21,370,40.4,7.66,380.51,"other metabolic processes","cytosol;other cell component","other molecular function","PSAT1","ENSG00000135069; ENSGGOG00000015480; ENSPPAG00000036829; ENSPTRG00000021045","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling","Serine biosynthesis","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Vitamin B6 metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors",8437.9,8551.1,8681.2,8565.1,9706.1,9361,0.9289958816163751,-0.10625589395736956,0.13095506162043102,0.8828777107451291,0.33425862083436597,0.4759173830711724,3059]
["High","Q9Y618-1","Nuclear receptor corepressor 2 [OS=Homo sapiens]",6,14,22,13,2525,274.6,7.59,28.1,"","","","","","","","",925.9,1082.8,1023.4,1058.1,993.8,996.3,0.9947181943442032,-0.007640229739872171,0.920230821930242,0.0361032247008104,0.9622555588096062,0.016709571370430637,7467]
["High","Q9Y619","mitochondrial ornithine transporter 1 [OS=Homo sapiens]",5,2,3,2,301,32.7,9.13,6.35,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A15","ENSG00000102743","","Urea cycle","",232.4,213.5,215.6,229.2,238.8,242.1,0.9315589353612167,-0.10228105028973183,0.0853254801017915,1.0689212593930422,0.26218864566500905,0.5813861197847763,2541]
["High","Q9Y620-1","DNA repair and recombination protein RAD54B [OS=Homo sapiens]",2,2,3,2,910,102.9,8.12,4.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RAD54B","ENSG00000197275","Homologous recombination; DNA repair pathways, full network","","Homologous recombination",75.8,87.4,85.3,65.4,68,64.1,1.2582278481012659,0.33139319849782095,0.010532891615088925,1.977452384742261,0.08409081567547477,1.075251434871227,978]
["High","Q9Y624","Junctional adhesion molecule A [OS=Homo sapiens]",51,12,53,12,299,32.6,7.9,98.69,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","F11R","ENSG00000158769","1q21.1 copy number variation syndrome","Integrin cell surface interactions; Tight junction interactions; Cell surface interactions at the vascular wall; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Epithelial cell signaling in Helicobacter pylori infection",2461.8,2476.1,2488.7,2514.6,2428,2476.9,1.000956937799043,1.3799092786962513E-3,0.9324838113461704,0.03035869914828929,0.9683247238982442,0.013978979315282027,7519]
["High","Q9Y625","Glypican-6 [OS=Homo sapiens]",9,3,3,2,555,62.7,5.41,9.71,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC6","ENSG00000183098","miR-509-3p alteration of YAP1/ECM axis","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","",11.2,15.4,15.6,16.3,14.6,12.4,0.9745958429561203,-0.03712402601953941,0.8506042091267929,0.07027247255543431,0.9274567329789134,0.032706341623215916,7161]
["High","Q9Y639-1","Isoform 1 of Neuroplastin [OS=Homo sapiens]",33,8,26,8,282,31.3,6.87,63.74,"","","","NPTN","","","","",1423.6,1279.8,1344.5,1379,1220,1300.5,1.038056161046288,0.05388449867764907,0.46920065230499514,0.32864139277930676,0.683237354195711,0.16542839776753213,5362]
["Medium","Q9Y646","Carboxypeptidase Q [OS=Homo sapiens]",1,1,1,1,472,51.9,6.18,2.19,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CPQ","ENSG00000104324","","","",30.2,33.4,32,38.3,33.6,44.3,{"$f":"AVERAGE(T7746:V7746)/AVERAGE(W7746:Y7746)","v":0.8227194492254732},{"$f":"LOG(Z7746,2)","v":-0.28152754542378045},{"$f":"TTEST(T7746:V7746,W7746:Y7746,2,2)","v":0.10081692259916591},{"$f":"-LOG10(AB7746)","v":0.9964665633806962},{"$f":"AB7746*7808/AF7746","v":0.2848999390714033},{"$f":"-LOG10(AD7746)","v":0.5453076436385721},2763]
["High","Q9Y657","Spindlin-1 [OS=Homo sapiens]",47,10,30,9,262,29.6,6.96,54.87,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes","other membranes;cytosol;nucleus","other molecular function","SPIN1","ENSG00000106723","","","",936.5,918.7,904.2,998.3,1032.7,1008.6,0.9078168180023689,-0.13952687933256702,2.503673227248285E-3,2.6014223547202846,0.04353826404978754,1.3611288910649724,449]
["High","Q9Y664","KICSTOR complex protein kaptin [OS=Homo sapiens]",11,4,6,4,436,48.1,5.26,6.99,"cell organization and biogenesis;stress response;other biological processes","other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity","KPTN","ENSG00000118162","","Amino acids regulate mTORC1","",86.6,71.5,73.8,59.1,76.4,80.7,1.072617946345976,0.10113629691135335,0.5534995015409683,0.2568827658929448,0.7432027700828684,0.12889268029877665,5815]
["High","Q9Y666","Solute carrier family 12 member 7 [OS=Homo sapiens]",14,11,16,11,1083,119,6.71,33.91,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC12A7","ENSG00000113504","","Cation-coupled Chloride cotransporters","Collecting duct acid secretion",482.3,485.5,471.5,511.7,480.6,491.9,0.9697480123972511,-0.04431818108614732,0.2098265399768444,0.6781395807920451,0.43828935905275573,0.3582390731762229,3738]
["High","Q9Y672","Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",6,3,9,3,507,58.1,8.46,18.36,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG6","ENSG00000088035","GPCRs, other","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG6 causes CDG-1c","N-Glycan biosynthesis; Metabolic pathways",419.4,401.7,430.2,391.7,400.8,428.1,1.0251515648041947,0.035837222536991065,0.49760628223347975,0.3031141453547946,0.7052659015572718,0.15164711306948056,5509]
["High","Q9Y673","dolichyl-phosphate beta-glucosyltransferase [OS=Homo sapiens]",17,4,5,4,324,36.9,9.28,10.28,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ALG5","ENSG00000120697","","Synthesis of dolichyl-phosphate-glucose","N-Glycan biosynthesis; Metabolic pathways",134.8,141.5,127,129.2,128.2,124.9,1.0549306827099139,0.07714820557122767,0.18577248799473725,0.7310186024886182,0.4079053954620102,0.38944055012815887,3556]
["High","Q9Y676","28S ribosomal protein S18b, mitochondrial [OS=Homo sapiens]",7,1,1,1,258,29.4,9.38,3.86,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPS18B","ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Viral carcinogenesis",31.2,21.5,21.8,39.2,24,23.9,0.8553386911595867,-0.2254322932493406,0.5224030318729994,0.28199431120868595,0.7224447171208607,0.14119538036095108,5646]
["High","Q9Y678","Coatomer subunit gamma-1 [OS=Homo sapiens]",57,37,115,33,874,97.7,5.47,252.96,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","COPG1","ENSG00000181789","VEGFA-VEGFR2 signaling pathway","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",4003.6,4022.7,4123.3,3756.8,4107.5,3986.9,1.025178884838666,0.0358756694890499,0.4145369848615038,0.38243671576580396,0.6400444488429151,0.19378986473971305,5057]
["High","Q9Y679-1","Ancient ubiquitous protein 1 [OS=Homo sapiens]",11,6,16,6,476,53,8.09,37.45,"","","","","","","","",685.3,685.4,711.8,734.7,740.9,681.9,0.9652375434530707,-0.051044063813407405,0.29350458798077483,0.5323851055946968,0.5313433394282147,0.27462475908201306,4313]
["High","Q9Y692-1","Glucocorticoid modulatory element-binding protein 1 [OS=Homo sapiens]",17,8,12,7,573,62.6,4.83,30.46,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GMEB1","ENSG00000162419; ENSGGOG00000009221; ENSPPAG00000038756","","","",613.1,572.4,589.8,760.2,691.1,769.5,0.7993966138328529,-0.3230166332334526,5.615350409093221E-3,2.250623137712888,0.06281469340143248,1.2019387556774133,698]
["High","Q9Y696","Chloride intracellular channel protein 4 [OS=Homo sapiens]",74,15,177,14,253,28.8,5.59,365.42,"transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","transporter activity","CLIC4","ENSG00000169504","","","",6131.1,6219.1,5939.9,6314.1,5928.9,5654.4,1.0219417345536224,0.03131294415538242,0.5638708206686901,0.24882037881199395,0.7501624412644629,0.124844683666932,5869]
["High","Q9Y697","Cysteine desulfurase, mitochondrial [OS=Homo sapiens]",32,10,16,10,457,50.2,8.31,38.46,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","NFS1","ENSG00000244005","","","Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system",464.2,434.1,457.7,447.5,415.2,444.5,1.0373317013463892,0.05287728987802275,0.3030988229161878,0.5184157502110548,0.539702533484514,0.26784554325447874,4385]
["Low","Q9Y6A1","Protein O-mannosyl-transferase 1 [OS=Homo sapiens]",1,1,1,1,747,84.8,8.4,1.87,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","POMT1","ENSG00000130714","","O-linked glycosylation; Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2; Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1","Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Metabolic pathways",27.3,21.7,26.5,22.4,22.7,17.9,1.1984126984126986,0.26112481582516267,0.14935322544440613,0.8257853938996162,0.36272161252563706,0.4404265665012217,3215]
["High","Q9Y6A4","Cilia- and flagella-associated protein 20 [OS=Homo sapiens]",54,8,19,8,193,22.8,9.76,32.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","","CFAP20","ENSG00000070761","","","",722.2,702.4,738.4,596,825.6,675.5,1.0314243479090173,0.04463800745895033,0.7632353446350171,0.11734152611249575,0.8758585495164923,0.05756602639439171,6804]
["High","Q9Y6A5","Transforming acidic coiled-coil-containing protein 3 [OS=Homo sapiens]",48,33,102,33,838,90.3,5.05,203.73,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","","TACC3","ENSG00000013810","","Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus","",4007.3,4074.9,4010.2,3591.5,2988.7,3141.8,1.2438181444147298,0.3147755680008673,0.012294555103438546,1.910287182225591,0.09056215683740394,1.0430532428317258,1060]
["High","Q9Y6A9","Signal peptidase complex subunit 1 [OS=Homo sapiens]",17,2,5,2,102,11.8,9.31,8.44,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","translation activity;other molecular function","SPCS1","ENSG00000114902","","","Protein export",321.2,325.4,342.2,295.5,299,283.6,1.12606764605398,0.17129349677446765,0.009637848439475814,2.0160199075032548,0.08126600498426258,1.0900910895265539,926]
["High","Q9Y6B6","GTP-binding protein SAR1b [OS=Homo sapiens]",31,6,24,2,198,22.4,6.11,44.54,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SAR1B","ENSG00000152700","Sterol regulatory element-binding proteins (SREBP) signaling","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Chylomicron assembly","Protein processing in endoplasmic reticulum; Legionellosis",150,128.3,144.1,120.6,125.7,116.2,1.1652413793103447,0.22062883956879406,0.04696256646589629,1.3282481772732155,0.18698812797843867,0.7281859662823642,1961]
["High","Q9Y6B7","AP-4 complex subunit beta-1 [OS=Homo sapiens]",5,2,3,2,739,83.2,5.86,0,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","AP4B1","ENSG00000134262","","Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis","Lysosome",41.2,45.5,45.3,35.5,46,33.9,1.143847487001733,0.1938947056003332,0.2431700232095005,0.6140899637624185,0.4747865819504326,0.3235015632373048,3999]
["High","Q9Y6C9","Mitochondrial carrier homolog 2 [OS=Homo sapiens]",23,7,23,7,303,33.3,7.97,72.58,"other biological processes","other membranes;mitochondrion","","MTCH2","ENSG00000109919; ENSG00000285121","","","",1776.2,1515.8,1585.7,1456.3,1567.1,1589.3,1.0574500834652156,0.08058956307395325,0.3723561838810545,0.42904142924341854,0.6053210667797779,0.21801421122374534,4803]
["High","Q9Y6D0","selenoprotein K [OS=Homo sapiens]",10,1,2,1,94,10.6,10.86,2.47,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","SELENOK","ENSG00000113811","Selenium micronutrient network","","",161.9,103.5,95,66.2,69.5,64.6,1.7993010484273588,0.8474365900008307,0.06452344245759593,1.1902824701662804,0.2222316006655973,0.6531941856341623,2267]
["High","Q9Y6D5","Brefeldin A-inhibited guanine nucleotide-exchange protein 2 [OS=Homo sapiens]",16,27,51,17,1785,201.9,6.33,82.37,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARFGEF2","ENSG00000124198","","Association of TriC/CCT with target proteins during biosynthesis","Endocytosis",807,797.8,824.6,844.8,866,873.1,0.9402066643445954,-0.08895018825188024,0.011267145261352971,1.9481861065174377,0.08650331386494002,1.062967254781547,1017]
["High","Q9Y6D6","Brefeldin A-inhibited guanine nucleotide-exchange protein 1 [OS=Homo sapiens]",29,38,88,28,1849,208.6,5.85,167.77,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","ARFGEF1","ENSG00000066777","","","Endocytosis",3601.5,3664,3675.9,4155.9,4418.1,4217.3,0.855378264914434,-0.22536554595993658,1.7105292547030635E-3,2.7668694937984375,0.03730673860536737,1.4282127157836764,358]
["High","Q9Y6D9","mitotic spindle assembly checkpoint protein MAD1 [OS=Homo sapiens]",40,31,76,31,718,83,5.92,179.87,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD1L1","ENSG00000002822","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; CCL18 signaling pathway","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Viral carcinogenesis",3004.4,3110,3137.9,2919.3,2905.5,2905,1.0598524593919678,0.08386344316719757,0.013097707158923732,1.8828047238389043,0.09382284174025367,1.0276914171208924,1090]
["High","Q9Y6E0","Serine/threonine-protein kinase 24 [OS=Homo sapiens]",38,13,53,8,443,49.3,5.69,111.9,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","STK24","ENSG00000102572","","Apoptotic cleavage of cellular proteins","",1233.4,1207.4,1204.2,1252.4,1170.4,1198.4,1.0065724069369268,0.009450955042738648,0.7736433192360046,0.11145922044207526,0.881454404873008,0.054800147600834535,6853]
["High","Q9Y6E2","Basic leucine zipper and W2 domain-containing protein 2 [OS=Homo sapiens]",48,20,81,16,419,48.1,6.68,148.74,"developmental processes;other biological processes","other cell component","","BZW2","ENSG00000136261","","","",2310.4,2326.8,2376.2,2277.8,2426.4,2377.9,0.990299487440166,-0.014063202316574137,0.6582784763521715,0.1815903447473551,0.8128797000407647,0.08997372190193798,6323]
["High","Q9Y6G5","COMM domain-containing protein 10 [OS=Homo sapiens]",12,2,3,2,202,23,6.54,2.65,"","nucleus;other cell component","","COMMD10","ENSG00000145781","","Neddylation","",22.6,19,19.5,27.2,23.8,23,0.8256756756756757,-0.2763528906975826,0.0657765059272047,1.1819292001272708,0.22466446118968256,0.6484656215278983,2286]
["High","Q9Y6G9","Cytoplasmic dynein 1 light intermediate chain 1 [OS=Homo sapiens]",59,24,78,24,523,56.5,6.42,187.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","DYNC1LI1","ENSG00000144635","Ciliary landscape; Intraflagellar transport proteins binding to dynein","Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MHC class II antigen presentation; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection",3242.3,3470.9,3532.7,3394.5,3507.3,3516.2,0.983480514494145,-0.024031625933276856,0.5846220367648043,0.23312481835768453,0.7643551344707957,0.11670481275203692,5972]
["High","Q9Y6H1","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 [OS=Homo sapiens]",34,3,6,3,151,15.5,9.22,12.94,"cell organization and biogenesis;stress response;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","CHCHD2","ENSG00000106153","","Mitochondrial protein import","",216.3,197,178.4,244.9,210,214.9,0.8833980292624666,-0.17886448095670143,0.1672788531470153,0.7765589576750221,0.3840380139288137,0.4156257849491089,3401]
["High","Q9Y6I3","epsin-1 [OS=Homo sapiens]",18,8,17,1,576,60.3,4.83,58.15,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","EPN1","ENSG00000063245","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway","Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation","Endocytosis",198.4,195.9,188.3,193.3,170.3,159,1.1148105625717566,0.15679857682032766,0.13057791508335273,0.8841302699866009,0.3341698987121659,0.47603267297037255,3051]
["High","Q9Y6I3-1","Isoform 2 of Epsin-1 [OS=Homo sapiens]",16,8,17,1,662,69,5.05,58.01,"","","","EPN1","","","","",701.6,680,663.5,635.2,573,563.9,1.1540545115964111,0.20671137108254997,0.021888531335246424,1.6597833775091013,0.12393448344133724,0.9068078390263157,1379]
["High","Q9Y6I4-1","Ubiquitin carboxyl-terminal hydrolase 3 [OS=Homo sapiens]",21,8,11,8,520,58.9,8.18,20.69,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","USP3","ENSG00000140455","","Ub-specific processing proteases","",478.9,478.4,500.5,522.9,506,536.8,0.9310851376381172,-0.10301500225634887,0.03531775326175737,1.4520069318514461,0.15857447812984565,0.7997667091955231,1739]
["High","Q9Y6I9","Testis-expressed protein 264 [OS=Homo sapiens]",15,3,6,3,313,34.2,4.86,12.37,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TEX264","ENSG00000164081","","Platelet degranulation","",239.2,248.1,238.4,274.8,255.9,222,0.964129135113591,-0.052701701429247745,0.5984063729159559,0.2230037899639571,0.7743382432429208,0.11106929114429127,6034]
["High","Q9Y6J0","Calcineurin-binding protein cabin-1 [OS=Homo sapiens]",7,11,17,11,2220,246.2,6.02,37.06,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity","CABIN1","ENSG00000099991","","Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",715.4,710.2,679.9,679.6,656.9,670,1.0493396461500124,0.06948171938909863,0.06245108905115135,1.204459983794544,0.21856481546902273,0.6604197494197463,2231]
["High","Q9Y6J9","TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L [OS=Homo sapiens]",15,7,13,7,622,67.8,8.97,17.17,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF6L","ENSG00000162227","","HATs acetylate histones","Basal transcription factors",615,595.6,619.5,613.2,611.7,637.8,0.9824985236484672,-0.02547285538037797,0.38672871926686975,0.4125935751315033,0.6166178966787256,0.209983874491086,4897]
["High","Q9Y6K1","DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",44,31,99,4,912,101.8,6.57,170.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT3A","ENSG00000119772","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency","RMTs methylate histone arginines; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer",2737.7,2844.2,2932.5,3055.6,3133.7,3100.2,0.9165617094569137,-0.12569607835526045,0.013082642865490095,1.8833045139660747,0.0938009875975635,1.0277925890632142,1089]
["High","Q9Y6K1-2","Isoform 2 of DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",49,28,94,1,723,81.6,6.81,160.75,"","","","DNMT3A","","","","",33.2,38.9,31.4,40.9,45.7,42.9,0.7992277992277993,-0.32332133018722853,0.030947127295897502,1.5093796586775634,0.14924964170868912,0.8260867027723019,1619]
["Medium","Q9Y6K5","2'-5'-oligoadenylate synthase 3 [OS=Homo sapiens]",1,1,1,1,1087,121.1,8.4,2.19,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS3","ENSG00000111331","Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction","Interferon gamma signaling; OAS antiviral response; Interferon alpha/beta signaling","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease",19.6,17.3,16.7,20.3,21.8,25.2,0.7964338781575039,-0.32837350415254435,0.054663925323127985,1.2622991855784982,0.20529866711062209,0.6876138702513318,2079]
["High","Q9Y6K8","Adenylate kinase isoenzyme 5 [OS=Homo sapiens]",8,3,3,3,562,63.3,5.07,8.18,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK5","ENSG00000154027","","Interconversion of nucleotide di- and triphosphates","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors",64,72.7,61.1,87.3,68.3,89.5,0.807017543859649,-0.30932805810772906,0.1059855232237359,0.9747534518429398,0.29345211536557797,0.5324627555036655,2820]
["High","Q9Y6K9","NF-kappa-B essential modulator [OS=Homo sapiens]",10,4,4,4,419,48.2,5.71,10.06,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IKBKG","ENSG00000269335","Nucleotide-binding oligomerization domain (NOD) pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","Downstream TCR signaling; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; TICAM1, RIP1-mediated IKK complex recruitment; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Ovarian tumor domain proteases; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Primary immunodeficiency; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis",355.3,283.7,212.5,307,220.2,234.6,1.1177474402730374,0.16059424200256459,0.5761822830700758,0.2394400998966289,0.7590402001368571,0.1197352224770116,5927]
["High","Q9Y6M1","Insulin-like growth factor 2 mRNA-binding protein 2 [OS=Homo sapiens]",42,22,106,19,599,66.1,8.46,221.34,"transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP2","ENSG00000073792","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",3058.1,3002.2,3002.2,3260.3,3145.4,3144,0.9489826905557243,-0.07554632215853581,0.019201956083465,1.7166545279118748,0.11559666391649555,0.9370546993373196,1297]
["High","Q9Y6M4-4","Isoform 4 of Casein kinase I isoform gamma-3 [OS=Homo sapiens]",13,4,6,1,424,49,9.11,8.8,"","","","CSNK1G3","","","","",15.4,17.1,18.9,16.2,11.2,11.4,1.3247422680412373,0.40571170700675063,0.09413517244517303,1.0262480774781262,0.27580016001947877,0.5594054861820817,2665]
["High","Q9Y6M5","zinc transporter 1 [OS=Homo sapiens]",31,10,20,10,507,55.3,6.48,52.13,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A1","ENSG00000170385","Zinc homeostasis","Zinc efflux and compartmentalization by the SLC30 family","Mineral absorption",545.5,544.8,541.8,489.9,507.5,489.5,1.0976528347568766,0.13442183141855035,1.3172362047568155E-3,2.8803363410408935,0.033284725847058945,1.477755015807093,309]
["High","Q9Y6M7-7","Isoform 7 of Sodium bicarbonate cotransporter 3 [OS=Homo sapiens]",12,16,29,16,1259,140.7,6.62,38.28,"","","","SLC4A7","","","","",988.8,967.5,983.6,970,1099.4,1050.4,0.9423360471825116,-0.08568646270475966,0.19210643826017956,0.7164580799378159,0.41492865005130897,0.38202657690973013,3615]
["Medium","Q9Y6N6","Laminin subunit gamma-3 [OS=Homo sapiens]",1,1,1,1,1575,171.1,6.58,0,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes","other molecular function","LAMC3","ENSG00000050555","Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Small cell lung cancer; Malignant pleural mesothelioma","Non-integrin membrane-ECM interactions; Laminin interactions; MET activates PTK2 signaling","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer",23.6,33.3,31.4,24.7,36.7,29.6,0.9703296703296703,-0.04345310743759263,0.8536764696079026,0.06870668913037255,0.9286021001251746,0.032170338468958164,7178]
["High","Q9Y6N7","Roundabout homolog 1 [OS=Homo sapiens]",9,12,16,12,1651,180.8,6.04,30.93,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ROBO1","ENSG00000169855","Development of ureteric collection system","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; SLIT2:ROBO1 increases RHOA activity","Axon guidance",582.8,651.1,624.8,580.1,538.4,510.4,1.1410768002946774,0.1903958956366765,0.054166163330211535,1.2662719250465042,0.2041165073756234,0.6901218714610643,2072]
["High","Q9Y6P5","Sestrin-1 [OS=Homo sapiens]",5,2,2,2,492,56.5,6.09,4.43,"other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","SESN1","ENSG00000080546","miRNA regulation of DNA damage response; Mesodermal commitment pathway; Head and neck squamous cell carcinoma; p53 transcriptional gene network; DNA damage response","Amino acids regulate mTORC1","p53 signaling pathway; Longevity regulating pathway",76.8,73,78.7,62.1,61.9,63.1,1.221272047033672,0.28838460670464816,1.2985649652138222E-3,2.886536318404248,0.03324326310947385,1.478296353092398,305]
["High","Q9Y6Q1","Calpain-6 [OS=Homo sapiens]",5,3,3,3,641,74.5,7.05,6.71,"cell organization and biogenesis;protein metabolism;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CAPN6","ENSG00000077274","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",120.2,109.6,114.8,121.4,139.5,135.2,0.8699823276950266,-0.20094199967967136,0.05175526004720415,1.2860455049360577,0.19867505921758602,0.701856648864148,2034]
["High","Q9Y6Q2-3","Isoform 3 of Stonin-1 [OS=Homo sapiens]",11,8,10,7,1135,127.2,5.31,16.27,"","","","STON1","","","","",391,418.3,432.9,503.6,496.4,487,0.8353732347007395,-0.25950717449307503,0.003465946808655109,2.4601781066206105,0.051157112820376355,1.291093973997161,529]
["High","Q9Y6Q3-1","zinc finger protein 37 homolog [OS=Homo sapiens]",15,7,7,6,630,71.2,9.09,11.29,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZFP37","ENSG00000136866","","Generic Transcription Pathway","Herpes simplex virus 1 infection",200.2,179.9,190.7,224.1,222.8,215.8,0.8613248830541722,-0.21537058460066766,8.760712499754731E-3,2.0574605716711325,0.07835468865760016,1.1059350107180668,873]
["High","Q9Y6Q9-1","Nuclear receptor coactivator 3 [OS=Homo sapiens]",4,4,4,4,1424,155.2,7.47,2.79,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NCOA3","ENSG00000124151","Androgen receptor signaling pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway","Estrogen-dependent gene expression; MAPK6/MAPK4 signaling; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Endocrine resistance; Estrogen signaling pathway; Thyroid hormone signaling pathway; Pathways in cancer; Breast cancer",154.8,181.7,163.1,113.1,100.5,114.5,1.522706491923194,0.6066378830895375,0.003297566075115445,2.4818064935009216,0.05009220995039182,1.3002298078375618,514]
["High","Q9Y6R0","Numb-like protein [OS=Homo sapiens]",10,5,9,3,609,64.9,8.85,22.59,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction","other cell component","","NUMBL","ENSG00000105245","Notch signaling; Notch signaling pathway","","Notch signaling pathway",111.2,93.9,113.4,104.5,103.1,93.1,1.0591952111739276,0.08296850456965993,0.45239509099568653,0.3444821163130103,0.6701386587923204,0.17383532786933223,5271]
["High","Q9Y6R4-1","Mitogen-activated protein kinase kinase kinase 4 [OS=Homo sapiens]",6,9,15,9,1608,181.6,6.32,20.28,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","kinase activity;other molecular function","MAP3K4","ENSG00000085511","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)","","MAPK signaling pathway; GnRH signaling pathway",436.3,443.6,438.9,436.8,422.2,450.3,1.0072557855342552,0.01043009214583888,0.7250339550072209,0.13964165394354694,0.8538559759723049,0.06861537768968463,6630]
["Medium","Q9Y6V0-1","Protein piccolo [OS=Homo sapiens]",0,1,4,1,5065,552.9,6.51,8.88,"","","","","","","","",87.9,81.7,83,76,66.6,85,1.1098418277680142,0.15035408148097054,0.21342728792793364,0.6707500542701139,0.4421438748053345,0.3544363870610835,3769]
["High","Q9Y6V7","Probable ATP-dependent RNA helicase ddx49 [OS=Homo sapiens]",14,4,9,4,483,54.2,9.06,20.08,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX49","ENSG00000105671","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",264.6,242.2,257.7,255.4,298.1,279.8,0.9174366974678988,-0.12431947851166603,0.17747478603675487,0.7508633387380401,0.39648730454219805,0.4017707141611048,3495]
["High","Q9Y6W3","Calpain-7 [OS=Homo sapiens]",18,11,17,11,813,92.6,7.65,31.21,"protein metabolism;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CAPN7","ENSG00000131375","Integrin-mediated cell adhesion","Degradation of the extracellular matrix","",539.2,526,495.6,519.5,526,485.8,1.0192646770717693,0.02752873130397074,0.6127648483739575,0.21270615622644462,0.783568283017337,0.10592315153045223,6106]
["High","Q9Y6W5","Wiskott-Aldrich syndrome protein family member 2 [OS=Homo sapiens]",17,10,22,10,498,54.3,5.53,38.22,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","WASF2","ENSG00000158195","Regulation of actin cytoskeleton","RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs","Adherens junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Choline metabolism in cancer",1049.1,1007.5,1027.5,1081.8,1048,977.5,0.9925337109387571,-0.010811991343874188,0.826165309713178,0.0829330447944858,0.9127916708986125,0.03962833145057291,7067]
["High","Q9Y6X2","E3 SUMO-protein ligase PIAS3 [OS=Homo sapiens]",3,2,2,2,628,68,7.69,5.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","PIAS3","ENSG00000131788","Androgen receptor signaling pathway; Prolactin signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; EGF/EGFR signaling pathway; Regulatory circuits of the STAT3 signaling pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Interferon type I signaling pathways","SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMOylation of immune response proteins; SUMOylation of DNA replication proteins","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway",52.2,48.3,60.2,46.9,54.5,55,1.0274936061381073,0.03912941636774127,0.7595992626764476,0.1194154654933476,0.8737405779283592,0.05861749448035042,6788]
["High","Q9Y6X3-1","MAU2 chromatid cohesion factor homolog [OS=Homo sapiens]",5,2,2,2,613,69,7.25,5.55,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MAU2","ENSANAG00000026794; ENSCANG00000033671; ENSCATG00000015302; ENSCCAG00000031923; ENSCSAG00000005122; ENSG00000129933; ENSGGOG00000002989; ENSMFAG00000041829; ENSMNEG00000034232; ENSPPAG00000032359; ENSPTRG00000010738; ENSRBIG00000036077; ENSRROG00000032649; ENSSBOG00000034577","Cohesin complex - Cornelia de Lange syndrome","Cohesin Loading onto Chromatin","",81.1,74.4,92.6,117.6,90.3,96.8,0.8142435182146374,-0.2964677647940547,0.1265034456798138,0.8978976450861912,0.32695759810261044,0.4855085657008363,3021]
["High","Q9Y6X4-1","Soluble lamin-associated protein of 75 kDa [OS=Homo sapiens]",13,6,9,6,670,74.9,4.6,21.39,"","other membranes;nucleus","","FAM169A","ENSG00000198780","","RHOF GTPase cycle","",317.6,373.2,346.4,419.5,423.6,400.4,0.834097305991154,-0.26171239625097437,0.017348520905605035,1.7607375462285157,0.11003838442807808,0.9584557945011967,1231]
["High","Q9Y6X5","Bis(5'-adenosyl)-triphosphatase ENPP4 [OS=Homo sapiens]",5,2,2,2,453,51.6,6.15,2.38,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes","other molecular function","ENPP4","ENSG00000001561","","Neutrophil degranulation","Purine metabolism; Metabolic pathways",14,8.4,12.9,12.6,11.3,16.5,0.8737623762376237,-0.19468710948061466,0.50407634831833,0.2975036795422379,0.7099257084540983,0.14878709648735278,5544]
["High","Q9Y6X8","Zinc fingers and homeoboxes protein 2 [OS=Homo sapiens]",2,2,2,2,837,92.3,6.86,3.13,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZHX2","ENSG00000178764","","","",63.9,60.5,54.2,55.2,62.4,55.6,1.0311778290993074,0.044293150394498354,0.6502386776303273,0.18692720127815926,0.8084496170282796,0.09234704035671998,6280]
["High","Q9Y6X9-1","MORC family CW-type zinc finger protein 2 [OS=Homo sapiens]",23,18,39,18,1032,117.8,8.38,66.76,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","MORC2","ENSG00000133422","","Fatty acyl-CoA biosynthesis","",1750.6,1852.8,1847.4,1677,1681.6,1743.3,1.068386287461534,0.09543336448307904,0.04217149589679199,1.3749809935262833,0.17608290907066945,0.7542827954041469,1870]
["High","Q9Y6Y0","influenza virus NS1A-binding protein [OS=Homo sapiens]",10,5,7,5,642,71.7,5.53,11.53,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","IVNS1ABP","ENSG00000116679","","","",308.1,317.7,306.8,522.2,624.7,581.2,0.5396678432961054,-0.8898563695915995,8.9292485875599873E-4,3.0491850862409895,0.02857359548019196,1.5440351079210834,244]
["High","Q9Y6Y8","SEC23-interacting protein [OS=Homo sapiens]",14,16,38,16,1000,111,5.54,49.87,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC23IP","ENSG00000107651","","COPII-mediated vesicle transport","",1222.7,1298.8,1258.9,1283.9,1198.4,1250.3,1.0128060869099287,0.018357980424290876,0.6562388342932866,0.18293807291332514,0.8116446726060481,0.09063405758204354,6313]